TY - CPAPER T1 - Electron Transfer Mechanisms: Evolving Theoretical Probes and Contact with Experiment T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39244651; 4358794 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Newton, Marshall D Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Probes KW - Electron transfer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39244651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Electron+Transfer+Mechanisms%3A+Evolving+Theoretical+Probes+and+Contact+with+Experiment&rft.au=Newton%2C+Marshall+D&rft.aulast=Newton&rft.aufirst=Marshall&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aqueous High Oxidation State Iron: Generation and Reactivity T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39240693; 4358154 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Cabelli, Diane E AU - Sharma, Virender K Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Oxidation KW - Iron KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39240693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Aqueous+High+Oxidation+State+Iron%3A+Generation+and+Reactivity&rft.au=Cabelli%2C+Diane+E%3BSharma%2C+Virender+K&rft.aulast=Cabelli&rft.aufirst=Diane&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radiotracer Development for Imaging Studies in Addiction T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39237573; 4359795 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Fowler, Joanna S AU - Logan, Jean AU - Wang, Gene-Jack AU - Volkow, Nora D Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Addiction KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39237573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Radiotracer+Development+for+Imaging+Studies+in+Addiction&rft.au=Fowler%2C+Joanna+S%3BLogan%2C+Jean%3BWang%2C+Gene-Jack%3BVolkow%2C+Nora+D&rft.aulast=Fowler&rft.aufirst=Joanna&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Energies Governing Electron Transfer: What we Know, what we Need to Learn T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39235664; 4358808 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Miller, John R Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Energy KW - Electron transfer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39235664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Energies+Governing+Electron+Transfer%3A+What+we+Know%2C+what+we+Need+to+Learn&rft.au=Miller%2C+John+R&rft.aulast=Miller&rft.aufirst=John&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Situ Time-Resolved Characterization of Novel Cu-MoO sub(2) Catalysts during the Water Gas Shift Reaction T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39225721; 4357611 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Wen, Wen AU - Liu, Jing AU - White, Michael G AU - Hanson, Jonathan C AU - Rodriguez, Jose A Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Catalysts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39225721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=In+Situ+Time-Resolved+Characterization+of+Novel+Cu-MoO+sub%282%29+Catalysts+during+the+Water+Gas+Shift+Reaction&rft.au=Wen%2C+Wen%3BLiu%2C+Jing%3BWhite%2C+Michael+G%3BHanson%2C+Jonathan+C%3BRodriguez%2C+Jose+A&rft.aulast=Wen&rft.aufirst=Wen&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radiation Chemistry of Criticality-Safe Borated Ionic Liquids T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39219814; 4362694 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Szreder, Tomasz AU - Funston, Alison M AU - Wishart, James F AU - Reed, Christopher A AU - Kim, Kee-Chan Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Radiation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39219814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Radiation+Chemistry+of+Criticality-Safe+Borated+Ionic+Liquids&rft.au=Szreder%2C+Tomasz%3BFunston%2C+Alison+M%3BWishart%2C+James+F%3BReed%2C+Christopher+A%3BKim%2C+Kee-Chan&rft.aulast=Szreder&rft.aufirst=Tomasz&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improving Cold Flow Properties of Biodiesel T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39210366; 4358977 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Krishna, C R AU - Butcher, Thomas AU - Mahajan, Devinder Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Biomass KW - Fuels KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39210366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Improving+Cold+Flow+Properties+of+Biodiesel&rft.au=Krishna%2C+C+R%3BButcher%2C+Thomas%3BMahajan%2C+Devinder&rft.aulast=Krishna&rft.aufirst=C&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Proton-HZE-particle sequential dual-beam exposures increase anchorage-independent growth frequencies in primary human fibroblasts. AN - 68838187; 16953667 AB - The radiation field in deep space contains high levels of high-energy protons and substantially lower levels of high-atomic-number, high-energy (HZE) particles. Calculations indicate that cellular nuclei of human space travelers will be hit during a 3-year Mars mission by approximately 400 protons and approximately 0.4 HZE particles. Thus most cells in astronauts will be hit by a proton(s) before being hit by an HZE particle. To investigate effects of dual ion irradiations on human cells, we irradiated primary human neonatal fibroblasts with protons (1 GeV/nucleon, 20 cGy) followed from 2.5 min to 48 h later by iron or titanium ions (1 GeV/nucleon, 20 cGy) and then measured clonogenic survival and frequency of anchorage-independent growth. This frequency depends on the interval between hydrogen- and iron-ion irradiation, with a critical window between 2.5 min and 1 h producing about three times more anchorage-independent colonies per survivor than expected from simple addition of the two ions separately. The hydrogen-titanium-ion dual-beam irradiation produced similar increases that persisted to approximately 6 h. At longer intervals, anchorage-independent growth frequencies were similar to those expected for additivity. However, irradiation of cells with either an iron or a titanium particle first followed by protons produced only additive levels. JF - Radiation research AU - Zhou, Guangming AU - Bennett, Paula V AU - Cutter, Noelle C AU - Sutherland, Betsy M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 488 EP - 494 VL - 166 IS - 3 SN - 0033-7587, 0033-7587 KW - Protons KW - 0 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Cell Proliferation -- radiation effects KW - Cells, Cultured KW - Humans KW - Dose-Response Relationship, Radiation KW - Cell Survival -- radiation effects KW - Cell Adhesion -- radiation effects KW - Heavy Ions KW - Cosmic Radiation KW - Environmental Exposure KW - Fibroblasts -- radiation effects KW - Fibroblasts -- cytology KW - Fibroblasts -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68838187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Proton-HZE-particle+sequential+dual-beam+exposures+increase+anchorage-independent+growth+frequencies+in+primary+human+fibroblasts.&rft.au=Zhou%2C+Guangming%3BBennett%2C+Paula+V%3BCutter%2C+Noelle+C%3BSutherland%2C+Betsy+M&rft.aulast=Zhou&rft.aufirst=Guangming&rft.date=2006-09-01&rft.volume=166&rft.issue=3&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-09-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Late effects of radiation on the central nervous system: role of vascular endothelial damage and glial stem cell survival. AN - 68834700; 16953668 AB - Selective irradiation of the vasculature of the rat spinal cord was used in this study, which was designed specifically to address the question as to whether it is the endothelial cell or the glial progenitor cell that is the target responsible for late white matter necrosis in the CNS. Selective irradiation of the vascular endothelium was achieved by the intraperitoneal (ip) administration of a boron compound known as BSH (Na(2)B(12)H(11)SH), followed by local irradiation with thermal neutrons. The blood-brain barrier is known to exclude BSH from the CNS parenchyma. Thirty minutes after the ip injection of BSH, the boron concentration in blood was 100 microg (10)B/ g, while that in the CNS parenchyma was below the detection limit of the boron analysis system, <1 microg (10)B/g. An ex vivo clonogenic assay of the O2A (oligodendrocyte-type 2 astrocyte) glial progenitor cell survival was performed 1 week after irradiation and at various times during the latent period before white matter necrosis in the spinal cord resulted in myelopathy. One week after 4.5 Gy of thermal neutron irradiation alone (approximately one-third of the dose required to produce a 50% incidence of radiation myelopathy), the average glial progenitor cell surviving fraction was 0.03. The surviving fraction of glial progenitor cells after a thermal neutron irradiation with BSH for a comparable effect was 0.46. The high level of glial progenitor cell survival after irradiation in the presence of BSH clearly reflects the lower dose delivered to the parenchyma due to the complete exclusion of BSH by the blood-brain barrier. The intermediate response of glial progenitor cells after irradiation with thermal neutrons in the presence of a boron compound known as BPA (p-dihydroxyboryl-phenylalanine), again for a dose that represents one-third the ED(50) for radiation-induced myelopathy, reflects the differential partition of boron-10 between blood and CNS parenchyma for this compound, which crosses the blood-brain barrier, at the time of irradiation. The large differences in glial progenitor survival seen 1 week after irradiation were also maintained during the 4-5-month latent period before the development of radiation myelopathy, due to selective white matter necrosis, after irradiation with doses that would produce a high incidence of radiation myelopathy. Glial progenitor survival was similar to control values at 100 days after irradiation with a dose of thermal neutrons in the presence of BSH, significantly greater than the ED(100), shortly before the normal time of onset of myelopathy. In contrast, glial progenitor survival was less than 1% of control levels after irradiation with 15 Gy of thermal neutrons alone. This dose of thermal neutrons represents the approximate ED(90-100) for myelopathy. The response to irradiation with an equivalent dose of X rays (ED(90): 23 Gy) was intermediate between these extremes as it was to thermal neutrons in the presence of BPA at a slightly lower dose equivalent to the approximate ED(60) for radiation myelopathy. The conclusions from these studies, performed at dose levels approximately iso-effective for radiation-induced myelopathy as a consequence of white matter necrosis, were that the large differences observed in glial progenitor survival were directly related to the dose distribution in the parenchyma. These observations clearly indicate the relative importance of the dose to the vascular endothelium as the primary event leading to white matter necrosis. JF - Radiation research AU - Coderre, Jeffrey A AU - Morris, Gerard M AU - Micca, Peggy L AU - Hopewell, John W AU - Verhagen, Ilja AU - Kleiboer, Bert J AU - van der Kogel, Albert J AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 495 EP - 503 VL - 166 IS - 3 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Rats KW - Radiation Dosage KW - Animals KW - Rats, Inbred F344 KW - Cells, Cultured KW - Dose-Response Relationship, Radiation KW - Cell Survival -- radiation effects KW - Male KW - Endothelium, Vascular -- radiation effects KW - Spinal Cord -- radiation effects KW - Neuroglia -- radiation effects KW - Neuroglia -- pathology KW - Endothelium, Vascular -- pathology KW - Spinal Cord Diseases -- pathology KW - Spinal Cord Diseases -- etiology KW - Radiation Injuries -- pathology KW - Spinal Cord -- blood supply KW - Radiation Injuries -- etiology KW - Endothelium, Vascular -- injuries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68834700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Late+effects+of+radiation+on+the+central+nervous+system%3A+role+of+vascular+endothelial+damage+and+glial+stem+cell+survival.&rft.au=Coderre%2C+Jeffrey+A%3BMorris%2C+Gerard+M%3BMicca%2C+Peggy+L%3BHopewell%2C+John+W%3BVerhagen%2C+Ilja%3BKleiboer%2C+Bert+J%3Bvan+der+Kogel%2C+Albert+J&rft.aulast=Coderre&rft.aufirst=Jeffrey&rft.date=2006-09-01&rft.volume=166&rft.issue=3&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-09-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Tropical dendrochemistry; a novel approach to estimate age and growth from ringless trees AN - 51461693; 2007-038702 JF - Geophysical Research Letters AU - Poussart, P M AU - Myneni, S C B AU - Lanzirotti, A Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 5 EP - 5, L17711 PB - American Geophysical Union, Washington, DC VL - 33 IS - 17 SN - 0094-8276, 0094-8276 KW - tropical environment KW - calcium KW - Far East KW - oxygen KW - ion probe data KW - isotopes KW - Thailand KW - archives KW - mass spectra KW - paleoclimatology KW - Holocene KW - stable isotopes KW - Cenozoic KW - radioactive isotopes KW - geochronology KW - dates KW - carbon KW - absolute age KW - spectra KW - Asia KW - forests KW - alkaline earth metals KW - ringless trees KW - Quaternary KW - isotope ratios KW - global KW - C-13/C-12 KW - Miliusa velutina KW - O-18/O-16 KW - X-ray spectra KW - geochemical cycle KW - tree rings KW - metals KW - trees KW - seasonal variations KW - carbon cycle KW - C-14 KW - 03:Geochronology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51461693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Tropical+dendrochemistry%3B+a+novel+approach+to+estimate+age+and+growth+from+ringless+trees&rft.au=Poussart%2C+P+M%3BMyneni%2C+S+C+B%3BLanzirotti%2C+A&rft.aulast=Poussart&rft.aufirst=P&rft.date=2006-09-01&rft.volume=33&rft.issue=17&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1029%2F2006GL026929 L2 - http://www.agu.org/journals/gl/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 33 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - GPRLAJ N1 - SubjectsTermNotLitGenreText - absolute age; alkaline earth metals; archives; Asia; C-13/C-12; C-14; calcium; carbon; carbon cycle; Cenozoic; dates; Far East; forests; geochemical cycle; geochronology; global; Holocene; ion probe data; isotope ratios; isotopes; mass spectra; metals; Miliusa velutina; O-18/O-16; oxygen; paleoclimatology; Quaternary; radioactive isotopes; ringless trees; seasonal variations; spectra; stable isotopes; Thailand; tree rings; trees; tropical environment; X-ray spectra DO - http://dx.doi.org/10.1029/2006GL026929 ER - TY - JOUR T1 - Zinc coordination to multiple ligand atoms in organic-rich surface soils AN - 51367655; 2007-110260 JF - Environmental Science & Technology, ES & T AU - Martinez, Carmen Enid AU - Bazilevskaya, Katya A AU - Lanzirotti, Antonio Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 5688 EP - 5695 PB - American Chemical Society, Washington, DC VL - 40 IS - 18 SN - 0013-936X, 0013-936X KW - soils KW - zinc KW - toxic materials KW - sorption KW - X-ray diffraction data KW - pollutants KW - pollution KW - bioavailability KW - X-ray spectra KW - XANES spectra KW - spatial distribution KW - organic compounds KW - ligands KW - chemical reactions KW - wetlands KW - soil pollution KW - metals KW - X-ray fluorescence spectra KW - spectra KW - heterogeneity KW - chemical composition KW - geochemistry KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51367655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Zinc+coordination+to+multiple+ligand+atoms+in+organic-rich+surface+soils&rft.au=Martinez%2C+Carmen+Enid%3BBazilevskaya%2C+Katya+A%3BLanzirotti%2C+Antonio&rft.aulast=Martinez&rft.aufirst=Carmen&rft.date=2006-09-01&rft.volume=40&rft.issue=18&rft.spage=5688&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/10.1021%2Fes0608343 L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 34 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - bioavailability; chemical composition; chemical fractionation; chemical reactions; geochemistry; heterogeneity; ligands; metals; organic compounds; pollutants; pollution; soil pollution; soils; sorption; spatial distribution; spectra; toxic materials; wetlands; X-ray diffraction data; X-ray fluorescence spectra; X-ray spectra; XANES spectra; zinc DO - http://dx.doi.org/10.1021/es0608343 ER - TY - JOUR T1 - Synchrotron mu -XRF mapping of elemental distributions across coral skeleton micro-architecture AN - 50988426; 2008-092522 JF - Geochimica et Cosmochimica Acta AU - Hendy, E AU - Lanzirotti, A AU - Rasbury, T AU - Lough, J AU - Anonymous Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1 PB - Elsevier, New York, NY VL - 70 IS - 18S SN - 0016-7037, 0016-7037 KW - calcium KW - Southwest Pacific KW - halogens KW - Sr/Ca KW - West Pacific KW - XANES spectra KW - synchrotron radiation KW - modern KW - partitioning KW - laboratory studies KW - Zoantharia KW - Coral Sea KW - Anthozoa KW - X-ray fluorescence spectra KW - Invertebrata KW - ecology KW - spectra KW - trace elements KW - geochemistry KW - Porites KW - alkaline earth metals KW - experimental studies KW - reef environment KW - aragonite KW - living taxa KW - biochemistry KW - Great Barrier Reef KW - South Pacific KW - Coelenterata KW - bromine KW - X-ray spectra KW - Scleractinia KW - metals KW - Pandora Reef KW - Pacific Ocean KW - Cnidaria KW - carbonates KW - strontium KW - growth KW - 10:Invertebrate paleontology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50988426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Synchrotron+mu+-XRF+mapping+of+elemental+distributions+across+coral+skeleton+micro-architecture&rft.au=Hendy%2C+E%3BLanzirotti%2C+A%3BRasbury%2C+T%3BLough%2C+J%3BAnonymous&rft.aulast=Hendy&rft.aufirst=E&rft.date=2006-09-01&rft.volume=70&rft.issue=18S&rft.spage=A246&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2Fj.gca.2006.06.1591 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 16th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - PubXState - NY N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - alkaline earth metals; Anthozoa; aragonite; biochemistry; bromine; calcium; carbonates; Cnidaria; Coelenterata; Coral Sea; ecology; experimental studies; geochemistry; Great Barrier Reef; growth; halogens; Invertebrata; laboratory studies; living taxa; metals; modern; Pacific Ocean; Pandora Reef; partitioning; Porites; reef environment; Scleractinia; South Pacific; Southwest Pacific; spectra; Sr/Ca; strontium; synchrotron radiation; trace elements; West Pacific; X-ray fluorescence spectra; X-ray spectra; XANES spectra; Zoantharia DO - http://dx.doi.org/10.1016/j.gca.2006.06.1591 ER - TY - JOUR T1 - The next generation of synchrotron fluorescence imaging for geological applications AN - 50859473; 2008-099030 JF - Geochimica et Cosmochimica Acta AU - Ryan, Chris G AU - Siddons, D P AU - Moorhead, G AU - Dunn, P AU - Kirkham, R AU - Dragone, A AU - De Geronimo, G AU - Hough, Robert M AU - Etschmann, B E AU - Anonymous Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1 PB - Elsevier, New York, NY VL - 70 IS - 18S SN - 0016-7037, 0016-7037 KW - X-ray fluorescence KW - data processing KW - techniques KW - HYMOD KW - synchrotron radiation KW - GeoPIXE KW - computer programs KW - computers KW - X-ray analysis KW - synchrotrons KW - applications KW - algorithms KW - geochemistry KW - instruments KW - image analysis KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50859473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=The+next+generation+of+synchrotron+fluorescence+imaging+for+geological+applications&rft.au=Ryan%2C+Chris+G%3BSiddons%2C+D+P%3BMoorhead%2C+G%3BDunn%2C+P%3BKirkham%2C+R%3BDragone%2C+A%3BDe+Geronimo%2C+G%3BHough%2C+Robert+M%3BEtschmann%2C+B+E%3BAnonymous&rft.aulast=Ryan&rft.aufirst=Chris&rft.date=2006-09-01&rft.volume=70&rft.issue=18S&rft.spage=A550&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2Fj.gca.2006.06.1016 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 16th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 4 N1 - PubXState - NY N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - algorithms; applications; computer programs; computers; data processing; geochemistry; GeoPIXE; HYMOD; image analysis; instruments; synchrotron radiation; synchrotrons; techniques; X-ray analysis; X-ray fluorescence DO - http://dx.doi.org/10.1016/j.gca.2006.06.1016 ER - TY - CPAPER T1 - Image-Guided Localization of Positron Emitting Nanoparticles using Small Animal PET: Applications for Toxicokinetics and Toxicology T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40193967; 4334003 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Schiffer, Wynne AU - Shea, Colleen AU - Panessa-Warren, Barbara AU - Gang, Oleg AU - Van der Lelie, Daniel AU - Maye, Matthew AU - Ferrieri, Richard AU - Fowler, Joanna Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Nanoparticles KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40193967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Image-Guided+Localization+of+Positron+Emitting+Nanoparticles+using+Small+Animal+PET%3A+Applications+for+Toxicokinetics+and+Toxicology&rft.au=Schiffer%2C+Wynne%3BShea%2C+Colleen%3BPanessa-Warren%2C+Barbara%3BGang%2C+Oleg%3BVan+der+Lelie%2C+Daniel%3BMaye%2C+Matthew%3BFerrieri%2C+Richard%3BFowler%2C+Joanna&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RuBisCO without the Calvin Cycle Improves the Carbon Efficiency of Developing Green Seeds T2 - 2006 Joint Annual Meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists (Plant Biology 2006) AN - 40193456; 4330298 JF - 2006 Joint Annual Meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists (Plant Biology 2006) AU - Schwender, Joerg AU - Goffman, Fernando AU - Ohlrogge, John AU - Shachar-Hill, Yair Y1 - 2006/08/05/ PY - 2006 DA - 2006 Aug 05 KW - Calvin cycle KW - Ribulose-bisphosphate carboxylase KW - Seeds KW - Carbon cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40193456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Joint+Annual+Meeting+of+the+American+Society+of+Plant+Biologists+and+the+Canadian+Society+of+Plant+Physiologists+%28Plant+Biology+2006%29&rft.atitle=RuBisCO+without+the+Calvin+Cycle+Improves+the+Carbon+Efficiency+of+Developing+Green+Seeds&rft.au=Schwender%2C+Joerg%3BGoffman%2C+Fernando%3BOhlrogge%2C+John%3BShachar-Hill%2C+Yair&rft.aulast=Schwender&rft.aufirst=Joerg&rft.date=2006-08-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Joint+Annual+Meeting+of+the+American+Society+of+Plant+Biologists+and+the+Canadian+Society+of+Plant+Physiologists+%28Plant+Biology+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstracts.aspb.org/pb2006/public/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Understanding the Linkages between Gene, Enzyme and Metabolite T2 - 2006 Joint Annual Meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists (Plant Biology 2006) AN - 40188943; 4330911 JF - 2006 Joint Annual Meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists (Plant Biology 2006) AU - Rogers, Alistair AU - Weston, David AU - Tschaplinski, Timothy J AU - Wullschleger, Stan D Y1 - 2006/08/05/ PY - 2006 DA - 2006 Aug 05 KW - Metabolites KW - Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40188943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Joint+Annual+Meeting+of+the+American+Society+of+Plant+Biologists+and+the+Canadian+Society+of+Plant+Physiologists+%28Plant+Biology+2006%29&rft.atitle=Understanding+the+Linkages+between+Gene%2C+Enzyme+and+Metabolite&rft.au=Rogers%2C+Alistair%3BWeston%2C+David%3BTschaplinski%2C+Timothy+J%3BWullschleger%2C+Stan+D&rft.aulast=Rogers&rft.aufirst=Alistair&rft.date=2006-08-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Joint+Annual+Meeting+of+the+American+Society+of+Plant+Biologists+and+the+Canadian+Society+of+Plant+Physiologists+%28Plant+Biology+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstracts.aspb.org/pb2006/public/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Total syntheses of three copper (II) tetracarboranylphenylporphyrins containing 40 or 80 boron atoms and their biological properties in EMT-6 tumor-bearing mice. AN - 68095652; 16651000 AB - Three carboranyltetraphenylporphyrins containing 40 or 80 boron atoms were synthesized and evaluated for their biodistribution and toxicity in EMT-6 tumor-bearing mice. Copper (II) meso-5,10,15,20-tetrakis[3-methoxy-4-(o-carboranylmethoxy)phenyl]porphyrin, 6, and copper (II) meso-5,10,15,20-tetrakis[3-hydroxy-4-(o-carboranylmethoxy)phenyl]porphyrin, 8, are B40 congeners with different lipophilicities, each less than their B80 congener, copper (II) meso-5,10,15,20-tetrakis[m-(3,5-di-o-carboranylmethoxybenzyloxy)phenyl]porphyrin, 18. Two days after the last of a series of i.p. injections in BALB/c mice bearing EMT-6 mammary tumors, a dose of 185 mg/kg 6 (54 mg/kg B) delivered over 3.5 times the concentration of boron to tumor (169 microg/g B) than did 118 mg/kg 8 (36 mg/kg B), which delivered 35 microg/g B, or 87 mg/kg 18 (30 mg/kg B), which delivered 46 microg/g B. The tumor-to-blood and tumor-to-brain boron concentration ratios at that time for all three porphyrins exceeded 80:1. Two days after the last injection, there resulted moderate thrombocytopenia that essentially disappeared two days later from 6 and 18, and mild leukocytosis from 6, 8, and 18, all of which were clinically inconsequential. Thus, 6 may rank among the most clinically promising carboranyl porphyrins ever made to deliver 10B to tumors for boron neutron-capture therapy (BNCT) that has also been tested for its toxicity in vivo. JF - Bioorganic & medicinal chemistry AU - Wu, Haitao AU - Micca, Peggy L AU - Makar, Michael S AU - Miura, Michiko AD - Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 5083 EP - 5092 VL - 14 IS - 15 SN - 0968-0896, 0968-0896 KW - Antineoplastic Agents KW - 0 KW - Boron Compounds KW - Metalloporphyrins KW - copper (II) meso-5,10,15,20-tetrakis(3-methoxy-4-(o-carboranylmethoxy)phenyl)porphyrin KW - Copper KW - 789U1901C5 KW - Index Medicus KW - Molecular Structure KW - Drug Screening Assays, Antitumor KW - Animals KW - Stereoisomerism KW - Transplantation, Heterologous KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Tissue Distribution KW - Mice, Inbred BALB C KW - Metalloporphyrins -- toxicity KW - Antineoplastic Agents -- pharmacokinetics KW - Mammary Neoplasms, Experimental -- blood supply KW - Antineoplastic Agents -- toxicity KW - Mammary Neoplasms, Experimental -- drug therapy KW - Antineoplastic Agents -- chemical synthesis KW - Boron Compounds -- chemical synthesis KW - Mammary Neoplasms, Experimental -- metabolism KW - Metalloporphyrins -- chemical synthesis KW - Copper -- chemistry KW - Metalloporphyrins -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68095652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Total+syntheses+of+three+copper+%28II%29+tetracarboranylphenylporphyrins+containing+40+or+80+boron+atoms+and+their+biological+properties+in+EMT-6+tumor-bearing+mice.&rft.au=Wu%2C+Haitao%3BMicca%2C+Peggy+L%3BMakar%2C+Michael+S%3BMiura%2C+Michiko&rft.aulast=Wu&rft.aufirst=Haitao&rft.date=2006-08-01&rft.volume=14&rft.issue=15&rft.spage=5083&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=09680896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-22 N1 - Date created - 2006-06-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233. AN - 68076963; 16715483 AB - G-protein coupled receptors exist in both high and low agonist affinity conformations, with tracer levels of agonist radioligands preferentially binding to the former. The goal of the present study was to characterize the in vivo binding of the aminoalkyindole-based, CB1 receptor agonist, R-[125/131I]AM2233 ((2-[125/131I]iodo-phenyl)-[1-(1-methyl-piperidin-2-yl-methyl)-1H-indol-3-yl]-methanone), and to use this radiotracer to selectively measure the receptor occupancy by the related CB1 receptor agonist, WIN55212-2, to the agonist-preferring affinity state of the receptor. In mouse locomotor assays, both WIN55212-2 and AM2233 (racemic) produced an approximately 60% reduction in activity at 1 mg/kg, (i.v.) and completely inhibited activity at 3 mg/kg, confirming their agonist nature. In ex vivo autoradiography, preferential uptake of R-[131I]AM2233 was apparent in CB1 receptor-rich areas, including globus pallidus, substantia nigra, striatum, cerebellum, and hippocampus. Overall brain uptake of R-[131I]AM2233 was 1.3% injected activity/g at 5 min in mice. Coinjection of 3 mg/kg (i.v.) SR141716A, a CB1 receptor antagonist, with R-[125I]AM2233 inhibited the radiotracer binding almost to nonspecific levels in the striatum, globus pallidus, and substantia nigra, although residual binding to a non-CB1 receptor remained in the hippocampus. In contrast to the effect of SR141716A, coinjection of 10 mg/kg (i.v.) WIN55212-2, a high dose that produced an immediate and profound immobility and catalepsy in the mice, reduced CB1 receptor-specific binding of R-[125I]AM2233 in CB1 receptor-rich areas by only 21-43%. These observations suggest that the behavioral effects of CB1 receptor agonists are manifested with a relatively small fraction of the agonist-preferring affinity state of the receptor occupied. JF - Synapse (New York, N.Y.) AU - Dhawan, Jasbeer AU - Deng, Hongfeng AU - Gatley, S John AU - Makriyannis, Alexandros AU - Akinfeleye, Tolulope AU - Bruneus, Magalie AU - Dimaio, Alexis A AU - Gifford, Andrew N AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 93 EP - 101 VL - 60 IS - 2 SN - 0887-4476, 0887-4476 KW - 2-iodophenyl-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone KW - 0 KW - Benzoxazines KW - Cannabinoids KW - Indoles KW - Iodine Radioisotopes KW - Morpholines KW - Naphthalenes KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Win 55212-2 KW - 5H31GI9502 KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Naphthalenes -- pharmacology KW - Animals KW - Drug Interactions KW - Motor Activity -- physiology KW - Radioligand Assay KW - Piperidines -- metabolism KW - Rats KW - Indoles -- metabolism KW - Motor Activity -- drug effects KW - Morpholines -- metabolism KW - Male KW - Dose-Response Relationship, Drug KW - Binding, Competitive -- physiology KW - Morpholines -- pharmacology KW - Binding, Competitive -- drug effects KW - Mice KW - Protein Conformation -- drug effects KW - Binding Sites -- physiology KW - Piperidines -- pharmacology KW - Naphthalenes -- metabolism KW - Pyrazoles -- pharmacology KW - Rats, Sprague-Dawley KW - Binding Sites -- drug effects KW - Indoles -- pharmacology KW - Iodine Radioisotopes -- metabolism KW - Behavior, Animal -- drug effects KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Receptor, Cannabinoid, CB1 -- agonists KW - Neurons -- metabolism KW - Cannabinoids -- metabolism KW - Neurons -- drug effects KW - Brain -- drug effects KW - Brain -- anatomy & histology KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Behavior, Animal -- physiology KW - Brain -- metabolism KW - Cannabinoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68076963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Evaluation+of+the+in+vivo+receptor+occupancy+for+the+behavioral+effects+of+cannabinoids+using+a+radiolabeled+cannabinoid+receptor+agonist%2C+R-%5B125%2F131I%5DAM2233.&rft.au=Dhawan%2C+Jasbeer%3BDeng%2C+Hongfeng%3BGatley%2C+S+John%3BMakriyannis%2C+Alexandros%3BAkinfeleye%2C+Tolulope%3BBruneus%2C+Magalie%3BDimaio%2C+Alexis+A%3BGifford%2C+Andrew+N&rft.aulast=Dhawan&rft.aufirst=Jasbeer&rft.date=2006-08-01&rft.volume=60&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-06-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Mineralogy and petrology of comet Wild-2 nucleus samples; final results of the preliminary examination team AN - 50652194; 2008-086202 JF - Meteoritics & Planetary Science AU - Zolensky, Michael E AU - Bland, Phil AU - Bradley, John AU - Brearley, Adrian J AU - Brennan, Sean AU - Bridges, John AU - Brownlee, Donald E AU - Butterworth, Anna L AU - Dai, Zurong AU - Ebel, Denton S AU - Genge, Matt AU - Gounelle, Matthieu AU - Graham, Giles AU - Grossman, Jeff AU - Grossman, Lawrence AU - Harvey, Ralph AU - Ishii, Hope A AU - Kearsley, Anton T AU - Keller, Lindsay AU - Krot, Alexander AU - Langenhorst, Falko AU - Lanzirotti, Antonio AU - Leroux, Hugues AU - Matrajt, Graciela AU - Messenger, Keiko AU - Mikouchi, Takashi AU - Nakamura, Tomoki AU - Ohsumi, Kazumasa AU - Okudaira, Kyoko AU - Perronnet, Murielle AU - Rietmeijer, Frans AU - Simon, Steven AU - Stephan, Thomas AU - Stroud, Rhonda M AU - Taheri, Mitra AU - Tomeoka, Kazu AU - Toppani, Alice AU - Tsou, Peter AU - Tsuchiyama, Akira AU - Velbel, Michael AU - Weber, Iris AU - Weisberg, Mike AU - Westphal, Andrew J AU - Yano, Hajime AU - Zega, Thomas J AU - Anonymous Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1 PB - Meteoritical Society, Fayetteville, AR VL - 41, Supplement SN - 1086-9379, 1086-9379 KW - alteration KW - physical properties KW - mineral composition KW - comets KW - Stardust Mission KW - Wild Comet KW - petrography KW - cometary dust KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50652194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Meteoritics+%26+Planetary+Science&rft.atitle=Mineralogy+and+petrology+of+comet+Wild-2+nucleus+samples%3B+final+results+of+the+preliminary+examination+team&rft.au=Zolensky%2C+Michael+E%3BBland%2C+Phil%3BBradley%2C+John%3BBrearley%2C+Adrian+J%3BBrennan%2C+Sean%3BBridges%2C+John%3BBrownlee%2C+Donald+E%3BButterworth%2C+Anna+L%3BDai%2C+Zurong%3BEbel%2C+Denton+S%3BGenge%2C+Matt%3BGounelle%2C+Matthieu%3BGraham%2C+Giles%3BGrossman%2C+Jeff%3BGrossman%2C+Lawrence%3BHarvey%2C+Ralph%3BIshii%2C+Hope+A%3BKearsley%2C+Anton+T%3BKeller%2C+Lindsay%3BKrot%2C+Alexander%3BLangenhorst%2C+Falko%3BLanzirotti%2C+Antonio%3BLeroux%2C+Hugues%3BMatrajt%2C+Graciela%3BMessenger%2C+Keiko%3BMikouchi%2C+Takashi%3BNakamura%2C+Tomoki%3BOhsumi%2C+Kazumasa%3BOkudaira%2C+Kyoko%3BPerronnet%2C+Murielle%3BRietmeijer%2C+Frans%3BSimon%2C+Steven%3BStephan%2C+Thomas%3BStroud%2C+Rhonda+M%3BTaheri%2C+Mitra%3BTomeoka%2C+Kazu%3BToppani%2C+Alice%3BTsou%2C+Peter%3BTsuchiyama%2C+Akira%3BVelbel%2C+Michael%3BWeber%2C+Iris%3BWeisberg%2C+Mike%3BWestphal%2C+Andrew+J%3BYano%2C+Hajime%3BZega%2C+Thomas+J%3BAnonymous&rft.aulast=Zolensky&rft.aufirst=Michael&rft.date=2006-08-01&rft.volume=41%2C+Supplement&rft.issue=&rft.spage=A167&rft.isbn=&rft.btitle=&rft.title=Meteoritics+%26+Planetary+Science&rft.issn=10869379&rft_id=info:doi/ L2 - http://cavern.uark.edu/~meteor/ LA - English DB - GeoRef N1 - Conference title - 69th annual meeting of the Meteoritical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - PubXState - AR N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - alteration; cometary dust; comets; mineral composition; petrography; physical properties; Stardust Mission; Wild Comet ER - TY - JOUR T1 - Binding and Transport of Metal Ions at the Dimer Interface of the Escherichia coli Metal Transporter YiiP AN - 19322365; 7061597 AB - YiiP is a representative member of the cation diffusion facilitator (CDF) family, a class of ubiquitous metal transporters that play an essential role in metal homeostasis. Recently, a pair of Zn super(2+)/Cd super(2+)-selective binding sites has been localized to two highly conserved aspartyl residues (Asp super(157)), each in a 2-fold-symmetry-related transmembrane segment 5 (TM5) of a YiiP homodimer. Here we report the functional and structural interactions between Asp super(157) and yet another highly conserved Asp super(49) in the TM2. Calorimetric binding analysis indicated that Asp super(49) and Asp super(157) contribute to a common Cd super(2+) binding site in each subunit. Copper phenanthroline oxidation of YiiP sub(D49C), YiiP sub(D157C), and YiiP sub(D49C/D157C) yielded inter- and intra-subunit cross-links among Cys super(49) and Cys super(157), consistent with the spatial proximity of two (Asp super(49)-Asp super(157)) sites at the dimer interface. Hg super(2+) binding to YiiP sub(D49C) or YiiP sub(D49C/D157C) also yielded a Cys super(49)-Hg super(2+)-Cys super(49) biscysteinate complex across the dimer interface, further establishing the interfacial location of a (Asp super(49)-Asp super(157)) sub(2) bimetal binding center. Two bound Cd super(2+) ions were found transported cooperatively with a sigmoidal dependence on the Cd super(2+) concentration (n = 1.4). The binding affinity, transport cooperativity, and rate were modestly reduced by either a D49C or D157C mutation, but greatly diminished when all the bidentate aspartate O-ligands in (Asp super(49)-Asp super(157)) sub(2) were replaced by the monodentate cysteine S-ligands. The functional significance of these findings is discussed based on the unique coordination chemistry of aspartyl residues and a model for the translocation pathway of metal ions at the YiiP dimer interface. JF - Journal of Biological Chemistry AU - Wei, Yinan AU - Fu, Dax AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 23492 EP - 23502 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 33 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Ions KW - Metals KW - Copper KW - Homeostasis KW - Models KW - Cations KW - Cysteine KW - Structure-function relationships KW - Oxidation KW - Zinc KW - Escherichia coli KW - Diffusion KW - Translocation KW - Mutation KW - Cooperativity KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19322365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Binding+and+Transport+of+Metal+Ions+at+the+Dimer+Interface+of+the+Escherichia+coli+Metal+Transporter+YiiP&rft.au=Wei%2C+Yinan%3BFu%2C+Dax&rft.aulast=Wei&rft.aufirst=Yinan&rft.date=2006-08-01&rft.volume=281&rft.issue=33&rft.spage=23492&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Metals; Ions; Homeostasis; Copper; Models; Cations; Structure-function relationships; Cysteine; Zinc; Oxidation; Diffusion; Mutation; Translocation; Cooperativity; Escherichia coli ER - TY - CPAPER T1 - On-farm Units to Produce Liquid and Easily Transportable Fuels T2 - 2006 Annual Conference of the Soil and Water Conservation Society (SWCS 2006) AN - 40232880; 4348575 JF - 2006 Annual Conference of the Soil and Water Conservation Society (SWCS 2006) AU - Mahajan, Devinder Y1 - 2006/07/22/ PY - 2006 DA - 2006 Jul 22 KW - Fuels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40232880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+Soil+and+Water+Conservation+Society+%28SWCS+2006%29&rft.atitle=On-farm+Units+to+Produce+Liquid+and+Easily+Transportable+Fuels&rft.au=Mahajan%2C+Devinder&rft.aulast=Mahajan&rft.aufirst=Devinder&rft.date=2006-07-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+Soil+and+Water+Conservation+Society+%28SWCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.swcs.org/documents/06_Final_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characteristic Response Time of Global Mean Surface Temperature T2 - 2006 Second International Conference on Global Warming and the Next Ice Age AN - 40198482; 4335616 JF - 2006 Second International Conference on Global Warming and the Next Ice Age AU - Schwartz, Stephen E Y1 - 2006/07/17/ PY - 2006 DA - 2006 Jul 17 KW - Temperature effects KW - Response time UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40198482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Second+International+Conference+on+Global+Warming+and+the+Next+Ice+Age&rft.atitle=Characteristic+Response+Time+of+Global+Mean+Surface+Temperature&rft.au=Schwartz%2C+Stephen+E&rft.aulast=Schwartz&rft.aufirst=Stephen&rft.date=2006-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Second+International+Conference+on+Global+Warming+and+the+Next+Ice+Age&rft.issn=&rft_id=info:doi/ L2 - http://aerosols.lanl.gov/conf2006/LANLClimateConfAbstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plant Uptake and Release of Cesium-137: Application to Phytoremediation. T2 - 18th World Congress of Soil Science (WCSS 2006) AN - 40058458; 4248498 JF - 18th World Congress of Soil Science (WCSS 2006) AU - Fuhrmann, Mark Y1 - 2006/07/09/ PY - 2006 DA - 2006 Jul 09 KW - Phytoremediation KW - Bioremediation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40058458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+World+Congress+of+Soil+Science+%28WCSS+2006%29&rft.atitle=Plant+Uptake+and+Release+of+Cesium-137%3A+Application+to+Phytoremediation.&rft.au=Fuhrmann%2C+Mark&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2006-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+World+Congress+of+Soil+Science+%28WCSS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://crops.confex.com/crops/wc2006/techprogram/AAG.HTM LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Crystal Structure of Escherichia coliL-Arabinose Isomerase (ECAI), The Putative Target of Biological Tagatose Production AN - 19456502; 6999971 AB - Escherichia coliL-arabinose isomerase (ECAI; EC 5.3.1.4) catalyzes the isomerization of L-arabinose to L-ribulose in vivo. This enzyme is also of commercial interest as it catalyzes the conversion of D-galactose to D-tagatose in vitro. The crystal structure of ECAI was solved and refined at 2.6 A resolution. The subunit structure of ECAI is organised into three domains: an N-terminal, a central and a C-terminal domain. It forms a crystallographic trimeric architecture in the asymmetric unit. Packing within the crystal suggests the idea that ECAI can form a hexameric assembly. Previous electron microscopic and biochemical studies supports that ECAI is hexameric in solution. A comparison with other known structures reveals that ECAI adopts a protein fold most similar to E. coli fucose isomerase (ECFI) despite very low sequence identity 9.7%. The structural similarity between ECAI and ECFI with regard to number of domains, overall fold, biological assembly, and active site architecture strongly suggests that the enzymes have functional similarities. Further, the crystal structure of ECAI forms a basis for indentifying molecular determinants responsible for isomerization of arabinose to ribulose in vivo and galactose to tagatose in vitro. JF - Journal of Molecular Biology AU - Manjasetty, BA AU - Chance, M R AD - Center for Synchrotron Biosciences, National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA, mark.chance@case.edu Y1 - 2006/07/07/ PY - 2006 DA - 2006 Jul 07 SP - 297 EP - 309 PB - Elsevier Ltd VL - 360 IS - 2 SN - 0022-2836, 0022-2836 KW - fucose isomerase KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Galactose KW - L-Arabinose KW - D-Galactose KW - L-Arabinose isomerase KW - Isomerization KW - D-tagatose KW - Subunit structure KW - Protein structure KW - Protein folding KW - Escherichia coli KW - Crystal structure KW - Active sites KW - Structure-activity relationships KW - L-ribulose KW - G 07320:Bacterial genetics KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19456502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Crystal+Structure+of+Escherichia+coliL-Arabinose+Isomerase+%28ECAI%29%2C+The+Putative+Target+of+Biological+Tagatose+Production&rft.au=Manjasetty%2C+BA%3BChance%2C+M+R&rft.aulast=Manjasetty&rft.aufirst=BA&rft.date=2006-07-07&rft.volume=360&rft.issue=2&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2006.04.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Galactose; L-Arabinose; D-Galactose; L-Arabinose isomerase; Isomerization; D-tagatose; Protein structure; Subunit structure; Protein folding; Crystal structure; Active sites; L-ribulose; Structure-activity relationships; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2006.04.040 ER - TY - JOUR T1 - Crystal structure of trehalose-6-phosphate phosphatase-related protein: Biochemical and biological implications AN - 21345670; 6999062 AB - We report here the crystal structure of a trehalose-6-phosphate phosphatase-related protein (T6PP) from Thermoplasma acidophilum, TA1209, determined by the dual-wavelength anomalous diffraction (DAD) method. T6PP is a member of the haloacid dehalogenase (HAD) superfamily with significant sequence homology with trehalose-6-phosphate phosphatase, phosphoserine phosphatase, P-type ATPases and other members of the family. T6PP possesses a core domain of known a/b-hydrolase fold, characteristic of the HAD family, and a cap domain, with a tertiary fold consisting of a four-stranded b-sheet with two a-helices on one side of the sheet. An active-site magnesium ion and a glycerol molecule bound at the interface between the two domains provide insight into the mode of substrate binding by T6PP. A trehalose-6-phosphate molecule modeled into a cage formed by the two domains makes favorable interactions with the protein molecule. We have confirmed that T6PP is a trehalose phosphatase from amino acid sequence, three-dimensional structure, and biochemical assays. JF - Protein Science AU - Rao, Krishnamurthy N AU - Kumaran, Desigan AU - Seetharaman, Jayaraman AU - Bonanno, Jeffrey B AU - Burley, Stephen K AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. New York Structural Biology Center, New York, New York 10027, USA. SGX Pharmaceuticals, Inc., San Diego, California 92121, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1735 EP - 1744 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 15 IS - 7 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - Adenosinetriphosphatase KW - Thermoplasma acidophilum KW - trehalose-6-phosphate phosphatase KW - Trehalose KW - trehalose-6-phosphate KW - Glycerol KW - Homology KW - Crystal structure KW - Diffraction KW - Magnesium KW - Phosphoserine phosphatase KW - Amino acid sequence KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21345670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Crystal+structure+of+trehalose-6-phosphate+phosphatase-related+protein%3A+Biochemical+and+biological+implications&rft.au=Rao%2C+Krishnamurthy+N%3BKumaran%2C+Desigan%3BSeetharaman%2C+Jayaraman%3BBonanno%2C+Jeffrey+B%3BBurley%2C+Stephen+K%3BSwaminathan%2C+Subramanyam&rft.aulast=Rao&rft.aufirst=Krishnamurthy&rft.date=2006-07-01&rft.volume=15&rft.issue=7&rft.spage=1735&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Glycerol; Adenosinetriphosphatase; trehalose-6-phosphate; Homology; Crystal structure; Trehalose; trehalose-6-phosphate phosphatase; Diffraction; Magnesium; Phosphoserine phosphatase; Amino acid sequence; Thermoplasma acidophilum ER - TY - JOUR T1 - Metabolic correlates of toluene abuse: decline and recovery of function in adolescent animals. AN - 67975473; 16703400 AB - RATIONALEChildren and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism.OBJECTIVEUsing an animal model of drug reinforcement, we sought to identify a metabolic signature of toluene abuse in the adolescent rodent brain. Small animal PET (microPET), in combination with the glucose analog radiotracer, (18)FDG, were used to evaluate the metabolic consequences of inhaled toluene.METHODSThe exposure protocol paralleled our previously established method for assessing the conditioned reinforcing effects of toluene (5,000 ppm) using the conditioned place preference (CPP) paradigm. Animals were scanned at baseline and 2 h after the last exposure. Follow-up (18)FDG scans occurred 1 day, 3 weeks, and 2 months later.RESULTSAfter six pairings, 38% of the animals preferred the toluene paired chamber and 25% were averse. The immediate metabolic effect in toluene-exposed animals was a 20% decline in whole brain (18)FDG uptake. Twenty-four hours following the last exposure, the whole brain decline was 40%, and 2 months later, the decline was 30% of pretoluene levels. A region-by-region analysis demonstrated significant additional decreases in the pons, cerebellum, striatum, midbrain, temporal cortex, and hippocampus. Two months after toluene cessation, regions of complete metabolic recovery were the thalamus and cerebellum; however, the temporal cortex did not recover.CONCLUSIONSBrain uptake of (18)FDG appears to be a useful tool for examining the metabolic impact of toluene abuse, which include a profound decline followed by region-specific recovery after cessation. JF - Psychopharmacology AU - Schiffer, Wynne K AU - Lee, Dianne E AU - Alexoff, David L AU - Ferrieri, Rich AU - Brodie, Jonathan D AU - Dewey, Stephen L AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. wynne@bnl.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 159 EP - 167 VL - 186 IS - 2 SN - 0033-3158, 0033-3158 KW - Solvents KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Toluene KW - 3FPU23BG52 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Brain Mapping KW - Reinforcement (Psychology) KW - Tomography, Emission-Computed KW - Disease Models, Animal KW - Male KW - Solvents -- toxicity KW - Brain -- drug effects KW - Substance-Related Disorders -- etiology KW - Brain -- metabolism KW - Toluene -- toxicity KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Substance-Related Disorders -- psychology KW - Brain -- diagnostic imaging KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67975473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Metabolic+correlates+of+toluene+abuse%3A+decline+and+recovery+of+function+in+adolescent+animals.&rft.au=Schiffer%2C+Wynne+K%3BLee%2C+Dianne+E%3BAlexoff%2C+David+L%3BFerrieri%2C+Rich%3BBrodie%2C+Jonathan+D%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2006-06-01&rft.volume=186&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-20 N1 - Date created - 2006-05-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Expression of the E. coli fpg protein in CHO cells lowers endogenous oxypurine clustered damage levels and decreases accumulation of endogenous Hprt mutations AN - 19805077; 7422679 AB - Endogenous DNA damage clusters - two or more oxidized bases, abasic sites, or strand breaks within about 20 base pairs on opposing strands - can accumulate in unirradiated mammalian cells, and may be significant origins of spontaneous detrimental biological effects. Factors determining the levels of such endogenous clusters are largely unknown. To determine if cellular repair genotype can affect endogenous cluster levels in mammalian cells, the authors examined cluster levels, growth rates, and mutant frequencies in Chinese hamster ovary cells expressing the Escherichia coli glycosylase fpg protein, whose principal substrates are oxidized purines. In cells expressing high levels of fpg protein, the levels of oxypurine clustered damages were decreased while those of oxypyrimidine clusters and abasic clusters were unchanged. Furthermore, in these cells, the growth rates were increased and the level of spontaneous background mutants in the hypoxanthine guanine phosphoribosyl transferase gene was decreased. These results suggest that endogenous clusters are potentially detrimental DNA damages, and that their levels - as well as the detrimental consequences of their presence - can be effectively reduced by increased cellular activity of specific DNA repair proteins. Environ. Mol. Mutagen., 2006. Published 2006 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Paul, S AU - Gros, L AU - Laval, J AU - Sutherland, B M AD - Biology Department, Bldg. 463, 50 Bell Avenue, Brookhaven National Laboratory, Upton, NY 11973, USA, bms@bnl.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 311 EP - 319 VL - 47 IS - 5 SN - 0893-6692, 0893-6692 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Growth rate KW - Mutagens KW - Mutant frequency KW - DNA-formamidopyrimidine glycosylase KW - Genotypes KW - DNA repair KW - purines KW - Mutagenesis KW - DNA damage KW - Guanine KW - Mammalian cells KW - Escherichia coli KW - Hypoxanthine KW - Mutation KW - Fpg protein KW - Base pairs KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19805077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Expression+of+the+E.+coli+fpg+protein+in+CHO+cells+lowers+endogenous+oxypurine+clustered+damage+levels+and+decreases+accumulation+of+endogenous+Hprt+mutations&rft.au=Paul%2C+S%3BGros%2C+L%3BLaval%2C+J%3BSutherland%2C+B+M&rft.aulast=Paul&rft.aufirst=S&rft.date=2006-06-01&rft.volume=47&rft.issue=5&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20208 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Growth rate; Mutagens; DNA-formamidopyrimidine glycosylase; Mutant frequency; Genotypes; DNA repair; purines; Mutagenesis; DNA damage; Guanine; Mammalian cells; Hypoxanthine; Mutation; Fpg protein; Base pairs; Escherichia coli DO - http://dx.doi.org/10.1002/em.20208 ER - TY - CPAPER T1 - Magnetic Resonance Microscopy of a Mouse Model of Attention-Deficit-Hyperactivity Disorder: Role of D4 Dopamine Receptors T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40057221; 4245814 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Ma, Yu AU - Hof, Patrick R AU - Grant, Samuel Colles AU - Blackband, Stephen J AU - Lee, Hai-Dee AU - Marcelo, Rubinstein AU - Benveniste, Helene Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Microscopy KW - N.M.R. KW - Dopamine D4 receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40057221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Magnetic+Resonance+Microscopy+of+a+Mouse+Model+of+Attention-Deficit-Hyperactivity+Disorder%3A+Role+of+D4+Dopamine+Receptors&rft.au=Ma%2C+Yu%3BHof%2C+Patrick+R%3BGrant%2C+Samuel+Colles%3BBlackband%2C+Stephen+J%3BLee%2C+Hai-Dee%3BMarcelo%2C+Rubinstein%3BBenveniste%2C+Helene&rft.aulast=Ma&rft.aufirst=Yu&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Slotted Surface Coil for Magnetic Resonance Imaging at 4T T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40047487; 4245718 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Solis, Sergio AU - Wang, Ruiliang AU - Tomasi, Dardo AU - Rodriguez, Alfredo Odon Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40047487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Slotted+Surface+Coil+for+Magnetic+Resonance+Imaging+at+4T&rft.au=Solis%2C+Sergio%3BWang%2C+Ruiliang%3BTomasi%2C+Dardo%3BRodriguez%2C+Alfredo+Odon&rft.aulast=Solis&rft.aufirst=Sergio&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 'More' may be 'Less': Deficient Dichotic Listening Performance in Autism is Associated with Hyperactivation of Bilateral Language Brain Regions T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40045773; 4243788 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Bentwich, Jonathan AU - Maletic-Savatich, Mirjiana AU - Caparelli, Elisabeth AU - Anshul, Airen AU - Foerster, Bernd AU - Cohen, Michael AU - Pradhan, Kith AU - Ma, Jim AU - Benveniste, Helene Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Language KW - Autism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40045773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=%27More%27+may+be+%27Less%27%3A+Deficient+Dichotic+Listening+Performance+in+Autism+is+Associated+with+Hyperactivation+of+Bilateral+Language+Brain+Regions&rft.au=Bentwich%2C+Jonathan%3BMaletic-Savatich%2C+Mirjiana%3BCaparelli%2C+Elisabeth%3BAnshul%2C+Airen%3BFoerster%2C+Bernd%3BCohen%2C+Michael%3BPradhan%2C+Kith%3BMa%2C+Jim%3BBenveniste%2C+Helene&rft.aulast=Bentwich&rft.aufirst=Jonathan&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Cocaine on the Rat Brain Apparent Diffusion Coefficient, Cerebral Blood Volume and Mean Arterial Blood Pressure T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40019642; 4243774 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Du, Congwu AU - Ma, Yu AU - Forester, Bernd AU - Yu, Mei AU - Benveniste, Helene Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Blood KW - Blood pressure KW - Diffusion coefficients KW - Brain KW - Cocaine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Effect+of+Cocaine+on+the+Rat+Brain+Apparent+Diffusion+Coefficient%2C+Cerebral+Blood+Volume+and+Mean+Arterial+Blood+Pressure&rft.au=Du%2C+Congwu%3BMa%2C+Yu%3BForester%2C+Bernd%3BYu%2C+Mei%3BBenveniste%2C+Helene&rft.aulast=Du&rft.aufirst=Congwu&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. AN - 67932462; 16636269 AB - Gamma-secretase is an intramembrane-cleaving aspartyl protease required for the normal development of metazoans because it processes Notch within cellular membranes to release its signaling domain. More than two dozen additional substrates of diverse functions have been reported, including the Notch ligands Delta and Jagged, N- and E-cadherins, and a sodium channel subunit. The protease is causally implicated in Alzheimer's disease because it releases the neurotoxic amyloid beta-peptide (Abeta) from its precursor, APP. Gamma-secretase occurs as a large complex containing presenilin (bearing the active site aspartates), nicastrin, Aph-1, and Pen-2. Because the complex contains at least 18 transmembrane domains, crystallographic approaches to its structure are difficult and remote. We recently purified the human complex essentially to homogeneity from stably expressing mammalian cells. Here, we use EM and single-particle image analysis on the purified enzyme, which produces physiological ratios of Abeta40 and Abeta42, to obtain structural information on an intramembrane protease. The 3D EM structure revealed a large, cylindrical interior chamber of approximately 20-40 A in length, consistent with a proteinaceous proteolytic site that is occluded from the hydrophobic environment of the lipid bilayer. Lectin tagging of the nicastrin ectodomain enabled proper orientation of the globular, approximately 120-A-long complex within the membrane and revealed approximately 20-A pores at the top and bottom that provide potential exit ports for cleavage products to the extra- and intracellular compartments. Our reconstructed 3D map provides a physical basis for hydrolysis of transmembrane substrates within a lipid bilayer and release of the products into distinct subcellular compartments. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Lazarov, Vlado K AU - Fraering, Patrick C AU - Ye, Wenjuan AU - Wolfe, Michael S AU - Selkoe, Dennis J AU - Li, Huilin AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2006/05/02/ PY - 2006 DA - 2006 May 02 SP - 6889 EP - 6894 VL - 103 IS - 18 SN - 0027-8424, 0027-8424 KW - Multiprotein Complexes KW - 0 KW - Concanavalin A KW - 11028-71-0 KW - Amyloid Precursor Protein Secretases KW - EC 3.4.- KW - Endopeptidases KW - Aspartic Acid Endopeptidases KW - EC 3.4.23.- KW - BACE1 protein, human KW - EC 3.4.23.46 KW - Index Medicus KW - Animals KW - Concanavalin A -- metabolism KW - Models, Molecular KW - Humans KW - Microscopy, Electron KW - Image Processing, Computer-Assisted KW - Endopeptidases -- isolation & purification KW - Endopeptidases -- ultrastructure KW - Endopeptidases -- metabolism KW - Protein Structure, Tertiary KW - Endopeptidases -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67932462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Electron+microscopic+structure+of+purified%2C+active+gamma-secretase+reveals+an+aqueous+intramembrane+chamber+and+two+pores.&rft.au=Lazarov%2C+Vlado+K%3BFraering%2C+Patrick+C%3BYe%2C+Wenjuan%3BWolfe%2C+Michael+S%3BSelkoe%2C+Dennis+J%3BLi%2C+Huilin&rft.aulast=Lazarov&rft.aufirst=Vlado&rft.date=2006-05-02&rft.volume=103&rft.issue=18&rft.spage=6889&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-05 N1 - Date created - 2006-05-03 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Science. 1999 Dec 10;286(5447):2153-6 [10591646] J Struct Biol. 1999 Dec 1;128(1):82-97 [10600563] Annu Rev Biochem. 1999;68:1015-68 [10872471] Mol Cell. 2000 Sep;6(3):625-36 [11030342] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5 [11867728] Nat Cell Biol. 2002 May;4(5):E110-1; author reply E111-2 [11988746] Biochemistry. 2003 Jan 14;42(1):137-44 [12515548] Nature. 2003 Mar 27;422(6930):438-41 [12660785] Science. 2003 May 9;300(5621):980-4 [12738865] J Biol Chem. 2003 Sep 26;278(39):37213-22 [12857757] Science. 2003 Oct 31;302(5646):814-8 [14593165] Nature. 2004 Jan 1;427(6969):36-44 [14661030] Biochemistry. 2004 Jan 20;43(2):323-33 [14717586] Nat Rev Mol Cell Biol. 2004 Mar;5(3):177-87 [14990998] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Biochemistry. 2004 Aug 3;43(30):9774-89 [15274632] Nature. 2004 Aug 12;430(7001):806-10 [15306816] J Microsc. 1987 May;146(Pt 2):113-36 [3302267] Biochemistry. 1995 Aug 15;34(32):10272-8 [7640283] Nat Med. 1996 Aug;2(8):864-70 [8705854] J Struct Biol. 1996 Jan-Feb;116(1):190-9 [8742743] Cell. 1998 Feb 6;92(3):367-80 [9476896] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7109-14 [9618547] Biochemistry. 1998 Nov 24;37(47):16465-71 [9843412] Curr Opin Struct Biol. 1999 Oct;9(5):572-7 [10508764] Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17050-5 [15563588] J Biol Chem. 2005 Feb 11;280(6):4383-92 [15569674] Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3230-5 [15722417] J Mol Biol. 2005 Jun 10;349(3):659-69 [15890365] Nat Struct Mol Biol. 2005 Jun;12(6):552-3 [15880121] FEBS J. 2005 Jun;272(11):2727-33 [15943807] Cell. 2005 Aug 12;122(3):435-47 [16096062] J Biol Chem. 2005 Oct 21;280(42):35352-60 [16046406] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Enzymatic activity of the SARS coronavirus main proteinase dimer AN - 19784156; 7494476 AB - The enzymatic activity of the SARS coronavirus main proteinase dimer was characterized by a sensitive, quantitative assay. The new, fluorogenic substrate, (Ala-Arg-Leu-Gln-NH)2-Rhodamine, contained a severe acute respiratory syndrome coronavirus (SARS CoV) main proteinase consensus cleavage sequence and Rhodamine 110, one of the most detectable compounds known, as the reporter group. The gene for the enzyme was cloned in the absence of purification tags, expressed in Escherichia coli and the enzyme purified. Enzyme activity from the SARS CoV main proteinase dimer could readily be detected at low pM concentrations. The enzyme exhibited a high Km, and is unusually sensitive to ionic strength and reducing agents. JF - FEBS Letters AU - Graziano, Vito AU - McGrath, William J AU - Degruccio, Ann Marie AU - Dunn, John J AU - Mangel, Walter F AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA, mangel@bnl.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 2577 EP - 2583 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 580 IS - 11 SN - 0014-5793, 0014-5793 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Antiviral agents KW - Fluorogenic substrate KW - High throughput screening KW - Proteinase KW - Rhodamine KW - SARS KW - Ionic strength KW - Severe acute respiratory syndrome KW - Reducing agents KW - Escherichia coli KW - Conserved sequence KW - Enzymatic activity KW - rhodamine KW - SARS coronavirus KW - J 02320:Cell Biology KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19784156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Enzymatic+activity+of+the+SARS+coronavirus+main+proteinase+dimer&rft.au=Graziano%2C+Vito%3BMcGrath%2C+William+J%3BDegruccio%2C+Ann+Marie%3BDunn%2C+John+J%3BMangel%2C+Walter+F&rft.aulast=Graziano&rft.aufirst=Vito&rft.date=2006-05-01&rft.volume=580&rft.issue=11&rft.spage=2577&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2006.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ionic strength; Reducing agents; Severe acute respiratory syndrome; Conserved sequence; Proteinase; Enzymatic activity; rhodamine; Escherichia coli; SARS coronavirus DO - http://dx.doi.org/10.1016/j.febslet.2006.04.004 ER - TY - CPAPER T1 - Variability of Deep Convective Cloud Characteristics Across the Tropical Pacific T2 - 27th Conference on Hurricanes and Tropical Meteorology AN - 39885604; 4167972 JF - 27th Conference on Hurricanes and Tropical Meteorology AU - Jensen, Michael P Y1 - 2006/04/24/ PY - 2006 DA - 2006 Apr 24 KW - Tropical Pacific KW - Clouds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Conference+on+Hurricanes+and+Tropical+Meteorology&rft.atitle=Variability+of+Deep+Convective+Cloud+Characteristics+Across+the+Tropical+Pacific&rft.au=Jensen%2C+Michael+P&rft.aulast=Jensen&rft.aufirst=Michael&rft.date=2006-04-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Conference+on+Hurricanes+and+Tropical+Meteorology&rft.issn=&rft_id=info:doi/ L2 - http://ams.confex.com/ams/27Hurricanes/techprogram/program_339.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Knock-out of SO1377 gene, which encodes the member of a conserved hypothetical bacterial protein family COG2268, results in alteration of iron metabolism, increased spontaneous mutation and hydrogen peroxide sensitivity in Shewanella oneidensis MR-1. AN - 68006947; 16600046 AB - BACKGROUNDShewanella oneidensis MR-1 is a facultative, gram-negative bacterium capable of coupling the oxidation of organic carbon to a wide range of electron acceptors such as oxygen, nitrate and metals, and has potential for bioremediation of heavy metal contaminated sites. The complete 5-Mb genome of S. oneidensis MR-1 was sequenced and standard sequence-comparison methods revealed approximately 42% of the MR-1 genome encodes proteins of unknown function. Defining the functions of hypothetical proteins is a great challenge and may need a systems approach. In this study, by using integrated approaches including whole genomic microarray and proteomics, we examined knockout effects of the gene encoding SO1377 (gi24372955), a member of the conserved, hypothetical, bacterial protein family COG2268 (Clusters of Orthologous Group) in bacterium Shewanella oneidensis MR-1, under various physiological conditions.RESULTSCompared with the wild-type strain, growth assays showed that the deletion mutant had a decreased growth rate when cultured aerobically, but not affected under anaerobic conditions. Whole-genome expression (RNA and protein) profiles revealed numerous gene and protein expression changes relative to the wild-type control, including some involved in iron metabolism, oxidative damage protection and respiratory electron transfer, e. g. complex IV of the respiration chain. Although total intracellular iron levels remained unchanged, whole-cell electron paramagnetic resonance (EPR) demonstrated that the level of free iron in mutant cells was 3 times less than that of the wild-type strain. Siderophore excretion in the mutant also decreased in iron-depleted medium. The mutant was more sensitive to hydrogen peroxide and gave rise to 100 times more colonies resistant to gentamicin or kanamycin.CONCLUSIONOur results showed that the knock-out of SO1377 gene had pleiotropic effects and suggested that SO1377 may play a role in iron homeostasis and oxidative damage protection in S. oneidensis MR-1. JF - BMC genomics AU - Gao, Weimin AU - Liu, Yongqing AU - Giometti, Carol S AU - Tollaksen, Sandra L AU - Khare, Tripti AU - Wu, Liyou AU - Klingeman, Dawn M AU - Fields, Matthew W AU - Zhou, Jizhong AD - Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. wgao@bnl.gov Y1 - 2006/04/06/ PY - 2006 DA - 2006 Apr 06 SP - 76 VL - 7 KW - Bacterial Proteins KW - 0 KW - Siderophores KW - Hydrogen Peroxide KW - BBX060AN9V KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Phenotype KW - Gene Expression Regulation, Bacterial KW - Cells, Cultured KW - Models, Genetic KW - Electron Spin Resonance Spectroscopy KW - Proteomics KW - Transcription, Genetic KW - Siderophores -- biosynthesis KW - Cell Survival KW - Shewanella -- drug effects KW - Conserved Sequence -- genetics KW - Bacterial Proteins -- genetics KW - Hydrogen Peroxide -- pharmacology KW - Genes, Bacterial -- genetics KW - Shewanella -- growth & development KW - Mutagenesis -- genetics KW - Bacterial Proteins -- classification KW - Shewanella -- cytology KW - Iron -- metabolism KW - Shewanella -- genetics KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68006947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Knock-out+of+SO1377+gene%2C+which+encodes+the+member+of+a+conserved+hypothetical+bacterial+protein+family+COG2268%2C+results+in+alteration+of+iron+metabolism%2C+increased+spontaneous+mutation+and+hydrogen+peroxide+sensitivity+in+Shewanella+oneidensis+MR-1.&rft.au=Gao%2C+Weimin%3BLiu%2C+Yongqing%3BGiometti%2C+Carol+S%3BTollaksen%2C+Sandra+L%3BKhare%2C+Tripti%3BWu%2C+Liyou%3BKlingeman%2C+Dawn+M%3BFields%2C+Matthew+W%3BZhou%2C+Jizhong&rft.aulast=Gao&rft.aufirst=Weimin&rft.date=2006-04-06&rft.volume=7&rft.issue=&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-05-25 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Gene. 1995 Jul 4;160(1):63-7 [7628718] J Bacteriol. 1995 May;177(9):2305-14 [7730258] Exp Gerontol. 1995 Mar-Apr;30(2):99-124 [8591812] Anal Chem. 1996 Mar 1;68(5):850-8 [8779443] Mol Cell Biol. 1996 Nov;16(11):6303-12 [8887660] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13635-40 [8942986] EMBO J. 1996 Nov 15;15(22):6122-31 [8947034] Gene. 1997 Mar 25;188(1):69-75 [9099861] Int J Biochem Cell Biol. 1997 Feb;29(2):271-4 [9147127] J Biol Chem. 1997 May 23;272(21):13793-802 [9153235] J Bacteriol. 1997 Oct;179(20):6228-37 [9335267] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15189-93 [9860944] Curr Opin Microbiol. 1999 Apr;2(2):188-94 [10322176] FEBS Lett. 1999 Jul 30;456(1):13-6 [10452520] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2099-104 [15684069] EMBO J. 2000 Jun 1;19(11):2444-51 [10835343] Ann N Y Acad Sci. 1999;893:13-8 [10672226] J Bacteriol. 2005 Apr;187(7):2501-7 [15774893] FEMS Microbiol Rev. 2001 Aug;25(4):405-24 [11524131] Respir Physiol. 2001 Nov 15;128(3):393-401 [11718766] Appl Environ Microbiol. 2002 Feb;68(2):881-92 [11823232] J Bacteriol. 2002 Aug;184(16):4612-6 [12142431] Biotechnol Bioeng. 2002 Dec 20;80(6):637-49 [12378605] Nat Biotechnol. 2002 Nov;20(11):1118-23 [12368813] Nat Biotechnol. 2002 Nov;20(11):1093-4 [12410251] J Proteome Res. 2002 May-Jun;1(3):211-5 [12645897] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4191-6 [12651953] FEMS Microbiol Rev. 2003 Jun;27(2-3):239-61 [12829270] OMICS. 2003 Summer;7(2):177-91 [14506847] Proteomics. 2004 Jan;4(1):59-77 [14730672] J Biol Chem. 1975 May 25;250(10):4007-21 [236308] Anal Biochem. 1978 Apr;85(2):331-40 [646092] Anal Biochem. 1987 Jan;160(1):47-56 [2952030] Electrophoresis. 1991 Jul-Aug;12(7-8):536-43 [1717251] Infect Immun. 1991 Dec;59(12):4310-7 [1937792] Appl Environ Microbiol. 1994 Aug;60(8):2802-10 [8085824] FEBS Lett. 1995 Jan 30;358(3):273-7 [7843414] FEBS Lett. 1995 Oct 2;373(1):13-8 [7589424] N1 - Last updated - 2017-02-22 ER - TY - CPAPER T1 - Improved Representation of Cloud Droplet Activation and Autoconversion and their Implications for Estimating Aerosol Indirect Effects T2 - 2006 European Geosciences Union General Assembly (EGU 2006) AN - 39891686; 4172732 JF - 2006 European Geosciences Union General Assembly (EGU 2006) AU - Liu, Y AU - Daum, P AU - Mcgraw, R AU - Miller, M Y1 - 2006/04/02/ PY - 2006 DA - 2006 Apr 02 KW - Aerosols KW - Clouds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.atitle=Improved+Representation+of+Cloud+Droplet+Activation+and+Autoconversion+and+their+Implications+for+Estimating+Aerosol+Indirect+Effects&rft.au=Liu%2C+Y%3BDaum%2C+P%3BMcgraw%2C+R%3BMiller%2C+M&rft.aulast=Liu&rft.aufirst=Y&rft.date=2006-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cosis.net/members/meetings/programme/session_programme.php? m_id=29 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Emergency response guidance for the first 48 hours after the outdoor detonation of an explosive radiological dispersal device AN - 17172652; 6832327 AB - Strategies and decisions to protect emergency responders, the public, and critical infrastructure against the effects of a radiological dispersal device detonated outdoors must be made in the planning stage, not in the early period just after an attack. This contrasts with planning for small-scale types of radiological or nuclear emergencies, or for a large-scale nuclear-power-type accident that evolves over many hours or days before radioactivity is released to the environment, such that its effects can be prospectively modeled and analyzed. By the time it is known an attack has occurred, most likely there will have been casualties, all the radioactive material will have been released, plume growth will be progressing, and there will be no time left for evaluating possible countermeasures. This paper offers guidance to planners, first responders, and senior decision makers to assist them in developing strategies for protective actions and operational procedures for the first 48 hours after an explosive radiological dispersal device has been detonated. JF - Health Physics AU - Musolino, S V AU - Harper, F T AD - Brookhaven National Laboratory, Nonproliferation and National Security Department, P.O. Box 5000, Upton, NY 11973-5000, USA, musolino@bnl.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 377 EP - 385 VL - 90 IS - 4 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Accidents KW - Radioactive fallout KW - Emergency preparedness KW - Explosives KW - Plumes KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17172652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Emergency+response+guidance+for+the+first+48+hours+after+the+outdoor+detonation+of+an+explosive+radiological+dispersal+device&rft.au=Musolino%2C+S+V%3BHarper%2C+F+T&rft.aulast=Musolino&rft.aufirst=S&rft.date=2006-04-01&rft.volume=90&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Accidents; Radioactive fallout; Emergency preparedness; Explosives; Plumes ER - TY - CPAPER T1 - Gadolinium-Doped Liquid Scintillator for New Reactor Antineutrino Experiments T2 - 231st National Meeting of the American Chemical Society AN - 40098783; 4115463 JF - 231st National Meeting of the American Chemical Society AU - Yeh, Minfang Y1 - 2006/03/26/ PY - 2006 DA - 2006 Mar 26 KW - Nuclear reactors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40098783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=231st+National+Meeting+of+the+American+Chemical+Society&rft.atitle=Gadolinium-Doped+Liquid+Scintillator+for+New+Reactor+Antineutrino+Experiments&rft.au=Yeh%2C+Minfang&rft.aulast=Yeh&rft.aufirst=Minfang&rft.date=2006-03-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=231st+National+Meeting+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/231nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Quasiparticle breakdown in a quantum spin liquid AN - 19974279; 6736717 AB - Much of modern condensed matter physics is understood in terms of elementary excitations, or quasiparticles-fundamental quanta of energy and momentum. Various strongly interacting atomic systems are successfully treated as a collection of quasiparticles with weak or no interactions. However, there are interesting limitations to this description: in some systems the very existence of quasiparticles cannot be taken for granted. Like unstable elementary particles, quasiparticles cannot survive beyond a threshold where certain decay channels become allowed by conservation laws; their spectrum terminates at this threshold. Such quasiparticle breakdown was first predicted for an exotic state of matter-super-fluid super(4)He at temperatures close to absolute zero, a quantum Bose liquid where zero-point atomic motion precludes crystallization. Here we show, using neutron scattering, that quasiparticle breakdown can also occur in a quantum magnet and, by implication, in other systems with Bose quasiparticles. We have measured spin excitations in a two-dimensional quantum magnet, piperazinium hexachlorodicuprate (PHCC), in which spin-1/2 copper ions form a non-magnetic quantum spin liquid, and find remarkable similarities with excitations in superfluid super(4)He. We observe a threshold momentum beyond which the quasiparticle peak merges with the two-quasiparticle continuum. It then acquires a finite energy width and becomes indistinguishable from a leading-edge singularity, so that excited states are no longer quasiparticles but occupy a wide band of energy. Our findings have important ramifications for understanding excitations with gapped spectra in many condensed matter systems, ranging from band insulators to high-transition-temperature superconductors. JF - Nature AU - Stone, Matthew B AU - Zaliznyak, Igor A AU - Hong, Tao AU - Broholm, Collin L AU - Reich, Daniel H AD - Condensed Matter Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA, zaliznyak@bnl.gov Y1 - 2006/03/09/ PY - 2006 DA - 2006 Mar 09 SP - 187 EP - 190 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 440 IS - 7081 SN - 0028-0836, 0028-0836 KW - Sustainability Science Abstracts KW - Channels KW - Ions KW - Temperature KW - Conservation KW - Copper KW - Decay KW - Particulates KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19974279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Quasiparticle+breakdown+in+a+quantum+spin+liquid&rft.au=Stone%2C+Matthew+B%3BZaliznyak%2C+Igor+A%3BHong%2C+Tao%3BBroholm%2C+Collin+L%3BReich%2C+Daniel+H&rft.aulast=Stone&rft.aufirst=Matthew&rft.date=2006-03-09&rft.volume=440&rft.issue=7081&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature04593 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Channels; Ions; Temperature; Conservation; Particulates; Decay; Copper DO - http://dx.doi.org/10.1038/nature04593 ER - TY - JOUR T1 - Recent progress in the syntheses and biological evaluation of boronated porphyrins for boron neutron-capture therapy. AN - 67736134; 16529537 AB - Boronated porphyrins are an important class of tumor-localizing agents in two bimodal therapies for cancer currently under study experimentally and clinically; boron neutron-capture therapy (BNCT) and photodynamic therapy (PDT). The desirable properties for the boronated porphyrins are that they are easily synthesized, pure and well-characterized drugs, and that in vivo, they are stable, tumor-specific, with high tumor:blood and tumor:normal tissue boron concentration ratios, and cause minimal toxicity. A large number of new porphyrins and their syntheses are presented herein. The focus is primarily on porphyrins published within the past 5 years, but the implications and trends from porphyrins studied in vivo over the past 15 years are also reviewed. Many possess quite unusual, novel structures and others have appended cell-targeting moieties for greater tumor specificity. Besides the commonly used closo- and nido-o-carboranes other boron cages and modes of attachment are presented. These boron cages can selectively alter the lipophilic, hydrophilic and amphiphilic properties of the porphyrins as well as their boron content. New delivery modalities have also greatly improved the targeting potential of compounds previously deemed unsuitable for applications in BNCT. JF - Anti-cancer agents in medicinal chemistry AU - Renner, M W AU - Miura, M AU - Easson, M W AU - Vicente, M G H AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 145 EP - 157 VL - 6 IS - 2 SN - 1871-5206, 1871-5206 KW - Antineoplastic Agents KW - 0 KW - Boron Compounds KW - Porphyrins KW - Index Medicus KW - Animals KW - Humans KW - Photochemotherapy -- methods KW - Porphyrins -- chemical synthesis KW - Antineoplastic Agents -- chemical synthesis KW - Boron Neutron Capture Therapy -- methods KW - Boron Compounds -- chemical synthesis KW - Boron Compounds -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Porphyrins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67736134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+agents+in+medicinal+chemistry&rft.atitle=Recent+progress+in+the+syntheses+and+biological+evaluation+of+boronated+porphyrins+for+boron+neutron-capture+therapy.&rft.au=Renner%2C+M+W%3BMiura%2C+M%3BEasson%2C+M+W%3BVicente%2C+M+G+H&rft.aulast=Renner&rft.aufirst=M&rft.date=2006-03-01&rft.volume=6&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+agents+in+medicinal+chemistry&rft.issn=18715206&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression. AN - 67646454; 16465372 AB - Multiple genetic alterations are common in cancers including those of the breast. The mechanisms leading to these alterations such as point mutations, gene amplifications, deletions and replication error are often associated with frequent and consistent loss of heterozygosity (LOH) or microsatellite instability (MSI). Several cytological and molecular studies have shown high frequency loss of genetic information on the long arm of chromosome 11 (i.e., 11q) in various primary breast cancers. In the present study allelic alterations in a refined position on the long arm of chromosome 11 were studied to identify the spectrum of induced damage at different stages of malignant transformation of MCF-10F cell lines after exposure to high-LET radiation using alpha-particles and exposure to estradiol by using PCR-single strand conformation polymorphism (SSCP) and fluorescence in situ hybridization (FISH) analysis. Microsatellite markers were selected from chromosome 11 (11q23-q24 loci) and it was found that frequency of allelic imbalance occurs at different stages of tumor progression with a range of 15-45% depending on the marker studied. These results strongly suggested the presence of several tumor suppressor genes in this critical region of chromosome 11 (11q23-q24). It also represents the first indication of allele loss at these loci in human breast epithelial cells induced by radiation and estrogen treatment suggesting a potential interventional target in breast carcinogenesis. JF - International journal of oncology AU - Roy, D AU - Calaf, G M AU - Hande, M P AU - Hei, T K AD - Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 11973, USA. droy@bnl.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 667 EP - 674 VL - 28 IS - 3 SN - 1019-6439, 1019-6439 KW - Estrogens KW - 0 KW - Index Medicus KW - Breast Neoplasms -- genetics KW - Microsatellite Repeats -- genetics KW - Breast Neoplasms -- pathology KW - Humans KW - In Situ Hybridization, Fluorescence -- methods KW - Alpha Particles KW - Cell Line, Tumor KW - Cell Line, Transformed KW - Female KW - Loss of Heterozygosity KW - Estrogens -- pharmacology KW - Cell Transformation, Neoplastic -- radiation effects KW - Chromosomes, Human, Pair 11 -- genetics KW - Cell Transformation, Neoplastic -- drug effects KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67646454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Allelic+imbalance+at+11q23-q24+chromosome+associated+with+estrogen+and+radiation-induced+breast+cancer+progression.&rft.au=Roy%2C+D%3BCalaf%2C+G+M%3BHande%2C+M+P%3BHei%2C+T+K&rft.aulast=Roy&rft.aufirst=D&rft.date=2006-03-01&rft.volume=28&rft.issue=3&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-02-08 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The relationship between Cambrian-Ordovician high-TOC source rock development and paleoenvironment variations in the Tarim Basin, western China; carbon and oxygen isotope evidence AN - 50055182; 2010-031592 AB - Sedimentary elemental and isotopic records of seawater and its isotopic composition are the most promising recorders of the history of this planet on a geological time scale. The Tarim Basin of northwestern China contains thick marine Cambrian-Ordovician sediments. Stable carbon and oxygen isotope values of these sediments show that dramatic changes occurred in the Early Paleozoic. A drastic positive shift in carbon and oxygen isotopes at the boundary of the Precambrian and Cambrian suggests a remarkable cooling and drop in sea level occurred right before the transition. Then the beginning of the Cambrian or Paleozoic is marked by a rapid negative shift in both carbon and oxygen isotope values, suggesting a rapid warming of climate and large-scale rise in sea level. Drastic input of meteoric water is perhaps the major cause of the decrease in isotope values in these sediments. The optimal climate conditions of the Early Cambrian provide ideal conditions for the biological exploration of the Early Cambrian. Enhanced bioproduction in the Cambrian is shown also by the significantly higher TOC data. Severe fluctuations in climate and sea-level change as well as high TOC values marked the Early and Middle Cambrian. The later Cambrian and early Ordovician was probably a rather stable period of time in terms of climate and sea level in the region. By the end of the early Ordovician and the transition of the Early to Middle Ordovician, isotope signals were characterized by a severe negative shift. TOC reached a new high in the Middle Ordovician (from <0.5% to-5%), suggesting elevated bioproduction (and preservation). These lines of evidence all suggest enhanced climate conditions. The large volume of melted water from the nearby ice sheet brought in not only fresh water, but also nutrients, thus providing an optimal environment for another bioexplosion and optimal conditions for oil source formation. JF - Dizhixue Bao = Acta Geologica Sinica AU - Zhang, Shuichang AU - Wang, Ruiliang AU - Jin, Zhijun AU - Zhang, Baomin AU - Wang, Darui AU - Bian, Lizeng Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 459 EP - 466 PB - Science Press, Beijing VL - 80 IS - 3 SN - 0001-5717, 0001-5717 KW - petroleum exploration KW - Far East KW - oxygen KW - isotopes KW - source rocks KW - stratigraphic traps KW - Xinjiang China KW - petroleum KW - paleoclimatology KW - stable isotopes KW - Cambrian KW - geochemical indicators KW - Ordovician KW - total organic carbon KW - carbon KW - depositional environment KW - Asia KW - geochemistry KW - China KW - Paleozoic KW - isotope ratios KW - C-13/C-12 KW - O-18/O-16 KW - Tarim Basin KW - organic compounds KW - paleoenvironment KW - productive capacity KW - marine environment KW - traps KW - 29A:Economic geology, geology of energy sources KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50055182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dizhixue+Bao+%3D+Acta+Geologica+Sinica&rft.atitle=The+relationship+between+Cambrian-Ordovician+high-TOC+source+rock+development+and+paleoenvironment+variations+in+the+Tarim+Basin%2C+western+China%3B+carbon+and+oxygen+isotope+evidence&rft.au=Zhang%2C+Shuichang%3BWang%2C+Ruiliang%3BJin%2C+Zhijun%3BZhang%2C+Baomin%3BWang%2C+Darui%3BBian%2C+Lizeng&rft.aulast=Zhang&rft.aufirst=Shuichang&rft.date=2006-03-01&rft.volume=80&rft.issue=3&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Dizhixue+Bao+%3D+Acta+Geologica+Sinica&rft.issn=00015717&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 22 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - TCHPAX N1 - SubjectsTermNotLitGenreText - Asia; C-13/C-12; Cambrian; carbon; China; depositional environment; Far East; geochemical indicators; geochemistry; isotope ratios; isotopes; marine environment; O-18/O-16; Ordovician; organic compounds; oxygen; paleoclimatology; paleoenvironment; Paleozoic; petroleum; petroleum exploration; productive capacity; source rocks; stable isotopes; stratigraphic traps; Tarim Basin; total organic carbon; traps; Xinjiang China ER - TY - JOUR T1 - Use of Single-Point Genome Signature Tags as a Universal Tagging Method for Microbial Genome Surveys AN - 19972858; 6750662 AB - We developed single-point genome signature tags (SP-GSTs), a generally applicable, high-throughput sequencing-based method that targets specific genes to generate identifier tags from well-defined points in a genome. The technique yields identifier tags that can distinguish between closely related bacterial strains and allow for the identification of microbial community members. SP-GSTs are determined by three parameters: (i) the primer designed to recognize a conserved gene sequence, (ii) the anchoring enzyme recognition sequence, and (iii) the type IIS restriction enzyme which defines the tag length. We evaluated the SP-GST method in silico for bacterial identification using the genes rpoC, uvrB, and recA and the 16S rRNA gene. The best distinguishing tags were obtained with the restriction enzyme Csp6I upstream of the 16S rRNA gene, which discriminated all organisms in our data set to at least the genus level and most organisms to the species level. The method was successfully used to generate Csp6I-based tags upstream of the 16S rRNA gene and allowed us to discriminate between closely related strains of Bacillus cereus and Bacillus anthracis. This concept was further used successfully to identify the individual members of a defined microbial community. JF - Applied and Environmental Microbiology AU - van der Lelie, Daniel AU - Lesaulnier, Celine AU - McCorkle, Sean AU - Geets, Joke AU - Taghavi, Safiyh AU - Dunn, John AD - Brookhaven National Laboratory, Biology Department, Building 463, Upton, New York 11973. IRD, UR 101, IFR-BAIM, Universite de Provence, ESIL, F-13288 Marseille Cedex 09, France. and Universiteit Hasselt, Environmental Sciences, Building D, Universitaire Campus, Diepenbeek B3590, Belgium Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 2092 EP - 2101 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 3 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Data processing KW - Bacillus cereus KW - Conserved sequence KW - Enzymes KW - Primers KW - Bacillus anthracis KW - rRNA 16S KW - RecA protein KW - A 01450:Environmental Pollution & Waste Treatment KW - W 30965:Miscellaneous, Reviews KW - G 07770:Bacteria KW - W2 32243:Molecular methods KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19972858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Use+of+Single-Point+Genome+Signature+Tags+as+a+Universal+Tagging+Method+for+Microbial+Genome+Surveys&rft.au=van+der+Lelie%2C+Daniel%3BLesaulnier%2C+Celine%3BMcCorkle%2C+Sean%3BGeets%2C+Joke%3BTaghavi%2C+Safiyh%3BDunn%2C+John&rft.aulast=van+der+Lelie&rft.aufirst=Daniel&rft.date=2006-03-01&rft.volume=72&rft.issue=3&rft.spage=2092&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Enzymes; Conserved sequence; Primers; rRNA 16S; RecA protein; Bacillus cereus; Bacillus anthracis ER - TY - JOUR T1 - Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate AN - 17156854; 6765765 AB - Mycobacterium tuberculosis (Mtb) has the remarkable ability to resist killing by human macrophages. The 750 kDa proteasome, not available in most eubacteria except Actinomycetes, appears to contribute to Mtb's resistance. The crystal structure of the Mtb proteasome at 3.0 Aa resolution reveals a substrate-binding pocket with composite features of the distinct beta 1, beta 2 and beta 5 substrate binding sites of eukaryotic proteasomes, accounting for the broad specificity of the Mtb proteasome towards oligopeptides described in the companion article [Lin et al. (2006), Mol Microbiol doi:10.1111-j.1365-2958.2005.05035.x]. The substrate entrance at the end of the cylindrical proteasome appears open in the crystal structure due to partial disorder of the alpha -subunit N-terminal residues. However, cryo-electron microscopy of the core particle reveals a closed end, compatible with the density observed in negative-staining electron microscopy that depended on the presence of the N-terminal octapetides of the alpha -subunits in the companion article, suggesting that the Mtb proteasome has a gated structure. We determine for the first time the proteasomal inhibition mechanism of the dipeptidyl boronate N-(4-morpholine)carbonyl- beta -(1-naphthyl) -l-alanine-l-leucine boronic acid (MLN-273), an analogue of the antimyeloma drug bortezomib. The structure improves prospects for designing Mtb-specific proteasomal inhibitors as a novel approach to chemotherapy of tuberculosis. JF - Molecular Microbiology AU - Hu, Guiqing AU - Lin, Gang AU - Wang, Ming AU - Dick, Lawrence AU - Xu, Rui-Ming AU - Nathan, Carl AU - Li, Huilin AD - Biology Department, Brookhaven National Laboratory, 50 Bell Avenue, Upton, NY 11973, USA, hli@bnl.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 1417 EP - 1428 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 59 IS - 5 SN - 0950-382X, 0950-382X KW - peptidyl boronate KW - Microbiology Abstracts B: Bacteriology KW - Eubacterium KW - Macrophages KW - Core particles KW - Chemotherapy KW - proteasomes KW - Crystal structure KW - Oligopeptides KW - Drugs KW - Electron microscopy KW - Actinomycetes KW - Mycobacterium tuberculosis KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17156854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Structure+of+the+Mycobacterium+tuberculosis+proteasome+and+mechanism+of+inhibition+by+a+peptidyl+boronate&rft.au=Hu%2C+Guiqing%3BLin%2C+Gang%3BWang%2C+Ming%3BDick%2C+Lawrence%3BXu%2C+Rui-Ming%3BNathan%2C+Carl%3BLi%2C+Huilin&rft.aulast=Hu&rft.aufirst=Guiqing&rft.date=2006-03-01&rft.volume=69&rft.issue=10%2C+Suppl.&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - SuppNotes - Figures, 6; tables, 2; references, 42. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Chemotherapy; Core particles; Crystal structure; proteasomes; Drugs; Oligopeptides; Actinomycetes; Electron microscopy; Eubacterium; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1111/j.1365-2958.2005.05036.x ER - TY - CPAPER T1 - Behavior of Radionuclides and RCRA Elements in Tank Backfill Grouts T2 - 32nd annual Waste Management Symposia: HLW, TRU, LLW/ILW, Mixed, Hazardous Wastes and Environmental Management (WM 06) AN - 39891129; 4143476 JF - 32nd annual Waste Management Symposia: HLW, TRU, LLW/ILW, Mixed, Hazardous Wastes and Environmental Management (WM 06) AU - Fuhrmann, Mark AU - Gillow, Jeffrey AU - Westcott, Daniel Y1 - 2006/02/26/ PY - 2006 DA - 2006 Feb 26 KW - Waste management KW - Environmental regulations KW - RCRA KW - Government regulations KW - Hazardous wastes KW - Legislation KW - Federal regulations KW - Radioisotopes KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+annual+Waste+Management+Symposia%3A+HLW%2C+TRU%2C+LLW%2FILW%2C+Mixed%2C+Hazardous+Wastes+and+Environmental+Management+%28WM+06%29&rft.atitle=Behavior+of+Radionuclides+and+RCRA+Elements+in+Tank+Backfill+Grouts&rft.au=Fuhrmann%2C+Mark%3BGillow%2C+Jeffrey%3BWestcott%2C+Daniel&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2006-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+annual+Waste+Management+Symposia%3A+HLW%2C+TRU%2C+LLW%2FILW%2C+Mixed%2C+Hazardous+Wastes+and+Environmental+Management+%28WM+06%29&rft.issn=&rft_id=info:doi/ L2 - http://www.wmsym.org/pdf/WM06_Preliminary_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Using Lidar to Measure Perfluorocarbon Tracers for the Verification and Monitoring of Cap and Cover Systems AN - 877599065; 13727166 AB - Waste site cover systems used to prevent rainfall from reaching the waste need to remain intact throughout the lifetime of the waste site. Monitoring of these covers is needed to ascertain the performance and to determine if any degradation has occurred. Researchers at Brookhaven National Laboratory have used gaseous perfluorocarbon tracers (PFTs) to monitor the integrity of caps and covers for waste disposal sites. Detection of the PFTs currently uses gas chromatography techniques developed at BNL. This paper presents a potential approach to this wide-area screening problem by replacing conventional gas chromatography analysis with laser-based, lidar (Light Detection and Ranging) detection of the PFTs. Lidar can be used to scan the surface of the cover system, looking for fugitive PFTs. If successful this would enable the departure from soil gas analysis and instead look for PFTs in the air just above the soil surface. The advantages of using a lidar platform are multi-fold and include the elimination of soil monitoring ports. Benchtop and pilot-scale indoor experiments using an a continuous wave, line-tunable infrared CO sub(2) laser were used to detect PMCH (perfluoromethylcyclohexane, one of a group of PFTs used at BNL). Laboratory measurements of the absorption cross-section were the same order of magnitude compared to literature values for similar perfluorocarbon compounds. Initial benchtop, fixed cell length experiments were successful in detecting PMCH to levels of 10 ppb-m. To improve the lower limit of detection, a HgCdTe detector was purchased that was more specific to the lasing region of interest and hence had a higher sensitivity at this spectral region Using a pilot-scale lidar system in a 40m indoor hallway air concentrations of PMCH were then measured down to 1 ppb-m. These results are very promising and show great potential for monitoring the integrity of cover systems using lidar and PFTs. JF - Water, Air, & Soil Pollution AU - Heiser, John H AU - Sedlacek, Arthur J AD - Brookhaven National Laboratory, New York, USA, heiser@bnl.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 345 EP - 357 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 170 IS - 1-4 SN - 0049-6979, 0049-6979 KW - Environment Abstracts; Pollution Abstracts KW - Absorption KW - Lidar KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877599065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Using+Lidar+to+Measure+Perfluorocarbon+Tracers+for+the+Verification+and+Monitoring+of+Cap+and+Cover+Systems&rft.au=Heiser%2C+John+H%3BSedlacek%2C+Arthur+J&rft.aulast=Heiser&rft.aufirst=John&rft.date=2006-02-01&rft.volume=170&rft.issue=1-4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/10.1007%2Fs11270-005-9007-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Lidar DO - http://dx.doi.org/10.1007/s11270-005-9007-8 ER - TY - JOUR T1 - ALARA considerations for the whole body neutron irradiation facility source removal project at Brookhaven National Laboratory. AN - 70684729; 16404183 AB - This paper describes the activities that were involved with the safe removal of fourteen PuBe sources from the Brookhaven National Laboratory (BNL) Whole Body Neutron Irradiation Facility (WBNIF). As part of a Department of Energy and BNL effort to reduce the radiological inventory, the WBNIF was identified as having no future use. In order to deactivate the facility and eliminate the need for nuclear safety management and long-term surveillance, it was decided to remove the neutron sources and dismantle the facility. In addition, the sources did not have DOT Special Form documentation so they would need to be encapsulated once removed for offsite storage or disposal. The planning and the administrative as well as engineering controls put in place enabled personnel to safely remove and encapsulate the sources while keeping exposure as low as reasonably achievable (ALARA). JF - Health physics AU - Sullivan, Patrick T AD - Brookhaven National Laboratory, PO Box 5000, Building 860, Upton, NY 11973, USA. sulli@bnl.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - S18 EP - S23 VL - 90 IS - 2 Suppl SN - 0017-9078, 0017-9078 KW - Radioactive Waste KW - 0 KW - Index Medicus KW - Whole-Body Irradiation KW - Humans KW - Environmental Pollution -- prevention & control KW - Decontamination -- methods KW - Radiation Dosage KW - Radiation Monitoring -- standards KW - Radiation Monitoring -- methods KW - Safety Management -- methods KW - Health Facility Closure -- methods KW - Laboratories KW - Radioactive Waste -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70684729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=ALARA+considerations+for+the+whole+body+neutron+irradiation+facility+source+removal+project+at+Brookhaven+National+Laboratory.&rft.au=Sullivan%2C+Patrick+T&rft.aulast=Sullivan&rft.aufirst=Patrick&rft.date=2006-02-01&rft.volume=90&rft.issue=2+Suppl&rft.spage=S18&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-31 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Structures of wild-type and mutant human spermidine/spermine N super(1)-acetyltransferase, a potential therapeutic drug target AN - 19766981; 6715033 AB - Spermidine/spermine N super(1)-acetyltransferase (SSAT) is a key enzyme in the control of polyamine levels in human cells, as acetylation of spermidine and spermine triggers export or degradation. Increased intracellular polyamine levels accompany several types of cancers as well as other human diseases, and compounds that affect the expression, activity, or stability of SSAT are being explored as potential therapeutic drugs. We have expressed human SSAT from the cloned cDNA in Escherichia coli and have determined high-resolution structures of wild-type and mutant SSAT, as the free dimer and in binary and ternary complexes with CoA, acetyl-CoA (AcCoA), spermine, and the inhibitor N super(1),N super(11)-bis-(ethyl)-norspermine (BE-3-3-3). These structures show details of binding sites for cofactor, substrates, and inhibitor and provide a framework to understand enzymatic activity, mutations, and the action of potential drugs. Two dimer conformations were observed: a symmetric form with two open surface channels capable of binding substrate or cofactor, and an asymmetric form in which only one of the surface channels appears capable of binding and acetylating polyamines. SSAT was found to self-acetylate lysine-26 in the presence of AcCoA and absence of substrate, a reaction apparently catalzyed by AcCoA bound in the second channel of the asymmetric dimer. These unexpected and intriguing complexities seem likely to have some as yet undefined role in regulating SSAT activity or stability as a part of polyamine homeostasis. Sequence signatures group SSAT with proteins that appear to have thialysine N super( epsilon )-acetyltransferase activity. JF - Proceedings of the National Academy of Sciences, USA AU - Bewley, Maria C AU - Graziano, Vito AU - Jiang, Jiangsheng AU - Matz, Eileen AU - Studier, FWilliam AU - Pegg, Anthony E AU - Coleman, Catherine S AU - Flanagan, John M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 2063 EP - 2068 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 7 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Spermine KW - Enzymes KW - Homeostasis KW - Cancer KW - Acetylation KW - Cofactors KW - Spermidine KW - polyamines KW - Escherichia coli KW - N1-acetyltransferase KW - Enzymatic activity KW - Mutation KW - Drugs KW - Conformation KW - J 02310:Genetics & Taxonomy KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19766981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Structures+of+wild-type+and+mutant+human+spermidine%2Fspermine+N+super%281%29-acetyltransferase%2C+a+potential+therapeutic+drug+target&rft.au=Bewley%2C+Maria+C%3BGraziano%2C+Vito%3BJiang%2C+Jiangsheng%3BMatz%2C+Eileen%3BStudier%2C+FWilliam%3BPegg%2C+Anthony+E%3BColeman%2C+Catherine+S%3BFlanagan%2C+John+M&rft.aulast=Bewley&rft.aufirst=Maria&rft.date=2006-02-01&rft.volume=103&rft.issue=7&rft.spage=2063&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Spermine; Enzymes; Homeostasis; Cancer; Acetylation; Cofactors; Spermidine; polyamines; N1-acetyltransferase; Enzymatic activity; Drugs; Mutation; Conformation; Escherichia coli ER - TY - JOUR T1 - Spectrum of Complex DNA Damages Depends on the Incident Radiation AN - 17476568; 6658391 AB - Ionizing radiation induces bistranded clustered damages- two or more abasic sites, oxidized bases and strand breaks on opposite DNA strands within a few helical turns. Since clusters are refractory to repair and are potential sources of double-strand breaks (DSBs), they are potentially lethal and mutagenic. Although induction of single-strand breaks (SSBs) and isolated lesions has been studied extensively, little is known about the factors affecting induction of clusters other than DSBs. To determine whether the type of incident radiation could affect the yields or spectra of specific clusters, we irradiated genomic T7 DNA, a simple 40-kbp linear, blunt-ended molecule, with ion beams [iron (970 MeV/nucleon), carbon (293 MeV/nucleon), titanium (980 MeV/nucleon), silicon (586 MeV/nucleon), protons (1 GeV/nucleon)] or 100 kVp X rays and then quantified DSBs, Fpg-oxypurine clusters and Nfo-abasic clusters using gel electrophoresis, electronic imaging and number average length analysis. The yields (damages/Mbp Gy super(-1)) of all damages decreased with increasing linear energy transfer (LET) of the radiation. The relative frequencies of DSBs compared to abasic and oxybase clusters were higher for the charged particles-including the high-energy, low-LET protons-than for the ionizing photons. JF - Radiation Research AU - Hada, M AU - Sutherland, B M AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 223 EP - 230 PB - The Radiation Research Society VL - 165 IS - 2 SN - 0033-7587, 0033-7587 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Silicon KW - Titanium KW - Photons KW - Protons KW - Double-strand break repair KW - imaging KW - Gel electrophoresis KW - DNA damage KW - Carbon KW - Ionizing radiation KW - genomics KW - Iron KW - X 24210:Radiation & radioactive materials KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17476568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Spectrum+of+Complex+DNA+Damages+Depends+on+the+Incident+Radiation&rft.au=Hada%2C+M%3BSutherland%2C+B+M&rft.aulast=Hada&rft.aufirst=M&rft.date=2006-02-01&rft.volume=165&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1043%2F0033-7587%282006%291652.0.CO%3B2 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=165&issue=2&page=223 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - DNA damage; Titanium; Silicon; Carbon; Photons; Protons; Ionizing radiation; genomics; Double-strand break repair; Iron; imaging; Gel electrophoresis DO - http://dx.doi.org/10.1043/0033-7587(2006)165[223:SOCDDD]2.0.CO;2 ER - TY - JOUR T1 - A novel nicotinic acetylcholine receptor antagonist radioligand for PET studies AN - 17457446; 6647401 AB - Using positron emission tomography (PET) with a specific and selective radioligand targeting nicotinic acetylcholine receptor (nAChR) would allow us to better understand various nAChR related CNS disorders. The use of radiolabeled nAChR antagonists would provide a much safer pharmacological profile, avoiding most peripheral side effects that might be generated from radiolabeled nAChR agonists even at the tracer level; thus, PET imaging with nAChR antagonists would facilitate clinical application. A potent and selective nAChR antagonist was labeled and characterized with PET in non-human primates. Its high brain uptake, high signal-to-noise ratio, and high specific binding strongly suggest a great potential to carry out imaging studies in humans. In addition, the use of a C-11 radiotracer would allow us to perform multiple PET studies in the same individual within a short time frame. The presence of an iodine atom in the molecule also allows the possibility to label with radioiodine for SPECT studies. JF - Bioorganic and Medicinal Chemistry Letters AU - Ding, Yu-Shin AU - Kil, Kun-Eek AU - Lin, Kuo-Shyan AU - Ma, Wei AU - Yokota, Yasuno AU - Carroll, Ivy F AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA, ding@bnl.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1049 EP - 1053 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 4 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Tracers KW - Central nervous system KW - Neuroimaging KW - Brain KW - Positron emission tomography KW - Iodine KW - Side effects KW - Acetylcholine receptors (nicotinic) KW - Single photon emission computed tomography KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17457446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=A+novel+nicotinic+acetylcholine+receptor+antagonist+radioligand+for+PET+studies&rft.au=Ding%2C+Yu-Shin%3BKil%2C+Kun-Eek%3BLin%2C+Kuo-Shyan%3BMa%2C+Wei%3BYokota%2C+Yasuno%3BCarroll%2C+Ivy+F&rft.aulast=Ding&rft.aufirst=Yu-Shin&rft.date=2006-02-01&rft.volume=16&rft.issue=4&rft.spage=1049&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2005.10.075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Acetylcholine receptors (nicotinic); Positron emission tomography; Neuroimaging; Central nervous system; Side effects; Brain; Single photon emission computed tomography; Tracers; Iodine DO - http://dx.doi.org/10.1016/j.bmcl.2005.10.075 ER - TY - CPAPER T1 - Regional and Seasonal Variations in Marine Stratus Cloud Properties from MODIS Observations T2 - 14th Conference on Satellite Meteorology and Oceanography AN - 39764455; 4057016 JF - 14th Conference on Satellite Meteorology and Oceanography AU - Jensen, Michael P AU - Andrew, V D AU - Collins, W D AU - Zhang, G J AU - Luke, E Y1 - 2006/01/29/ PY - 2006 DA - 2006 Jan 29 KW - Seasonal variations KW - Clouds KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Conference+on+Satellite+Meteorology+and+Oceanography&rft.atitle=Regional+and+Seasonal+Variations+in+Marine+Stratus+Cloud+Properties+from+MODIS+Observations&rft.au=Jensen%2C+Michael+P%3BAndrew%2C+V+D%3BCollins%2C+W+D%3BZhang%2C+G+J%3BLuke%2C+E&rft.aulast=Jensen&rft.aufirst=Michael&rft.date=2006-01-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Conference+on+Satellite+Meteorology+and+Oceanography&rft.issn=&rft_id=info:doi/ L2 - http://ams.confex.com/ams/Annual2006/techprogram/program_312.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Crystal Structure of AqpZ Tetramer Reveals Two Distinct Arg-189 Conformations Associated with Water Permeation through the Narrowest Constriction of the Water-conducting Channel AN - 17468049; 6661144 AB - AqpZ is a homotetramer of four water-conducting channels that facilitate rapid water movements across the plasma membrane of Escherichia coli. Here we report a 3.2 Aa crystal structure of the tetrameric AqpZ (tAqpZ). All channel-lining residues in the four monomeric channels are found orientated in nearly identical positions with one marked exception at the narrowest channel constriction, where the side chain of a highly conserved Arg-189 adopts two distinct conformational orientations. In one of the four monomers, the guanidino group of Arg-189 points toward the periplasmic vestibule, opening up the constriction to accommodate the binding of a water molecule through a tridentate H-bond. In the other three monomers, the Arg-189 guanidino group bends over to form an H-bond with carbonyl oxygen of the Thr-183, thus occluding the channel. Therefore, the tAqpZ structure reveals two distinct Arg-189 confirmations associated with water permeation through the channel constrictions. Alternation between the two Arg-189 conformations disrupts continuous flow of water, thus regulating the open probability of the water pore. Further, the difference in Arg-189 displacements is correlated with a strong electron density found between the first transmembrane helices of two open channels, suggesting that the observed Arg-189 conformations are stabilized by asymmetrical subunit interactions in tAqpZ. JF - Journal of Biological Chemistry AU - Jiang, Jiansheng AU - Daniels, Brenda V AU - Fu, Dax AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973 Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 SP - 454 EP - 460 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 1 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Monomers KW - Oxygen KW - AqpZ protein KW - Plasma membranes KW - Channel pores KW - Channel opening KW - Escherichia coli KW - Crystal structure KW - carbonyls KW - Water KW - Conformational analysis KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17468049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Crystal+Structure+of+AqpZ+Tetramer+Reveals+Two+Distinct+Arg-189+Conformations+Associated+with+Water+Permeation+through+the+Narrowest+Constriction+of+the+Water-conducting+Channel&rft.au=Jiang%2C+Jiansheng%3BDaniels%2C+Brenda+V%3BFu%2C+Dax&rft.aulast=Jiang&rft.aufirst=Jiansheng&rft.date=2006-01-06&rft.volume=281&rft.issue=1&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Monomers; Oxygen; AqpZ protein; Plasma membranes; Channel pores; Channel opening; Crystal structure; carbonyls; Water; Conformational analysis; Escherichia coli ER - TY - JOUR T1 - DNA damage quantitation by alkaline gel electrophoresis. AN - 67930543; 16673887 AB - Quantifying DNA lesions provides a powerful way to assess the level of endogenous damage or the damage level induced by radiation, chemical or other agents, as well as the ability of cells to repair such damages. Quantitative gel electrophoresis of experimental DNAs along with DNA length standards, imaging the resulting dispersed DNA and calculating the population average length allows accurate measurement of lesion frequencies. Number average length analysis provides high sensitivity and does not require any specific distribution of lesions within the DNA molecules. These methods are readily applicable to strand breaks and ultraviolet radiation induced pyrimidine dimers, but can also be used-with appropriate modifications-for ionizing radiation-induced lesions such as oxidized bases and abasic sites. JF - Methods in molecular biology (Clifton, N.J.) AU - Sutherland, Betsy M AU - Bennett, Paula V AU - Sutherland, John C AD - Biology Department, Brookhaven National Laboratory, Upton, NY, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 251 EP - 273 VL - 314 SN - 1064-3745, 1064-3745 KW - Pyrimidine Dimers KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Cells, Cultured KW - Humans KW - Pyrimidine Dimers -- analysis KW - DNA Damage KW - Electrophoresis, Agar Gel -- standards KW - DNA -- chemistry KW - DNA -- radiation effects KW - Comet Assay -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67930543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=DNA+damage+quantitation+by+alkaline+gel+electrophoresis.&rft.au=Sutherland%2C+Betsy+M%3BBennett%2C+Paula+V%3BSutherland%2C+John+C&rft.aulast=Sutherland&rft.aufirst=Betsy&rft.date=2006-01-01&rft.volume=314&rft.issue=&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-05-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - An FTIR study of hydrogen in anorthoclase and associated melt inclusions AN - 51619032; 2006-022851 AB - High-resolution Fourier transform infrared (FTIR) spectroscopy has been used to document the presence of hydrogen, to estimate its concentration, and to document its oxygen speciation in anorthoclase crystals and associated melt inclusions from Mount Erebus, Antarctica. Synchrotron-generated infrared radiation, 100 to 1000 times brighter than globar-generated infrared radiation, permits rapid collection of maps that depict relative intensities of a chosen FTIR band across the mapped area. Spectra and/or compositional maps showing variations in water concentration were collected from anorthoclase megacrysts and melt inclusions in the megacrysts. Studies of anorthoclase megacrysts involved collection of spectra from three mutually perpendicular sections cut from the crystals. FTIR spectra of anorthoclase crystals are characterized by a broad absorption band at approximately 3200 cm (super -1) in the mid-IR range. The universal mass absorption coefficient for mid-IR range feldspar spectra, established by Johnson and Rossman (2003), was used for quantitative estimates of water concentrations in the feldspar crystals based on integrated area under the 3200 cm (super -1) band. Water concentration in the anorthoclase sample was approximately 126 ppm, with an overall error of approximately + or -30%. FTIR spectra of melt inclusions are characterized by a broad asymmetric absorption band at approximately 3550 cm (super -1) that was used to calculate total water concentration. The absence of a band at 1630 cm (super -1) suggests that water in the melt inclusions occurs as OH (super -) rather than as molecular H (sub 2) O. Absorption coefficients established by Mandeville et al. (2002) for H species in glass were used to calculate water concentrations in the melt inclusions. Melt inclusions in the Mt. Erebus anorthoclase have water concentrations ranging from 0.12 to 0.39 wt%, with an overall error of approximately + or -15%. The ratio of water in anorthoclase crystals to water in the melt from which the crystals formed, based on this study, and at these low melt water concentrations, is approximately 1:10. However, water concentration varies significantly from one melt inclusion to another, possibly suggesting initial melt water heterogeneity. Maps of water concentration show that variations in water concentration within melt inclusions are associated with fractures that cut the melt inclusions and in some cases do not extend out into surrounding crystals or into crystal inclusions. Thin (approximately 50 mu m thick) zones of elevated water concentrations on the boundaries of the crystals in contact with melt inclusions suggest that water has diffused into the crystals from the melt inclusions. JF - American Mineralogist AU - Seaman, Sheila J AU - Dyar, M Darby AU - Marinkovic, Nebojsa AU - Dunbar, Nelia W Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 12 EP - 20 PB - Mineralogical Society of America, Washington, DC VL - 91 IS - 1 SN - 0003-004X, 0003-004X KW - silicates KW - volcanic rocks KW - igneous rocks KW - anorthoclase KW - phonolites KW - melt inclusions KW - infrared spectra KW - FTIR spectra KW - Antarctica KW - alkali feldspar KW - hydrogen KW - inclusions KW - framework silicates KW - fluid inclusions KW - spectra KW - feldspar group KW - phenocrysts KW - megacrysts KW - Mount Erebus KW - 01B:Mineralogy of silicates KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51619032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=An+FTIR+study+of+hydrogen+in+anorthoclase+and+associated+melt+inclusions&rft.au=Seaman%2C+Sheila+J%3BDyar%2C+M+Darby%3BMarinkovic%2C+Nebojsa%3BDunbar%2C+Nelia+W&rft.aulast=Seaman&rft.aufirst=Sheila&rft.date=2006-01-01&rft.volume=91&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/10.2138%2Fam.2006.1765 L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Abstract, copyright, Mineralogical Society of America | Reference includes data from GeoScienceWorld, Alexandria, VA, United States N1 - Date revised - 2006-01-01 N1 - Number of references - 48 N1 - PubXState - DC N1 - Document feature - illus. incl. table N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - alkali feldspar; anorthoclase; Antarctica; feldspar group; fluid inclusions; framework silicates; FTIR spectra; hydrogen; igneous rocks; inclusions; infrared spectra; megacrysts; melt inclusions; Mount Erebus; phenocrysts; phonolites; silicates; spectra; volcanic rocks DO - http://dx.doi.org/10.2138/am.2006.1765 ER - TY - JOUR T1 - A climatologically significant aerosol longwave indirect effect in the Arctic AN - 51251933; 2008-067052 JF - Nature (London) AU - Lubin, D AU - Vogelmann, A M Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 453 EP - 456 PB - Macmillan Journals, London VL - 439 IS - 7075 SN - 0028-0836, 0028-0836 KW - clouds KW - albedo KW - monitoring KW - pollutants KW - human activity KW - Arctic region KW - sea ice KW - pollution KW - atmosphere KW - global change KW - environmental effects KW - climate change KW - temperature KW - air pollution KW - ice KW - solar radiation KW - aerosols KW - greenhouse effect KW - climate KW - meltwater KW - global warming KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51251933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+%28London%29&rft.atitle=A+climatologically+significant+aerosol+longwave+indirect+effect+in+the+Arctic&rft.au=Lubin%2C+D%3BVogelmann%2C+A+M&rft.aulast=Lubin&rft.aufirst=D&rft.date=2006-01-01&rft.volume=439&rft.issue=7075&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Nature+%28London%29&rft.issn=00280836&rft_id=info:doi/ L2 - http://www.nature.com/nature/index.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 27 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - NATUAS N1 - SubjectsTermNotLitGenreText - aerosols; air pollution; albedo; Arctic region; atmosphere; climate; climate change; clouds; environmental effects; global change; global warming; greenhouse effect; human activity; ice; meltwater; monitoring; pollutants; pollution; sea ice; solar radiation; temperature ER - TY - JOUR T1 - Mineralogy and petrology of comet Wild2 nucleus samples AN - 50274063; 2007-046373 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Zolensky, Michael AU - Bland, Phil AU - Bradley, John AU - Brearley, Adrian J AU - Brennan, Sean AU - Bridges, John AU - Brownlee, Donald AU - Butterworth, Anna L AU - Dai, Zurong AU - Ebel, Denton AU - Genge, Matt AU - Gounelle, Matthieu AU - Graham, Giles AU - Grossman, Lawrence AU - Harvey, Ralph P AU - Ishii, Hope AU - Kearsley, Anton AU - Keller, Lindsay AU - Krot, Alexander N AU - Lanzirotti, Antonio AU - Leroux, Hugues AU - Messenger, Keiko AU - Mikouchi, Takashi AU - Nakamura, Tomoki AU - Ohsumi, Kazumasa AU - Okudaira, Kyoko AU - Perronnet, Murielle AU - Rietmeijer, Frans AU - Simon, Steven AU - Stephan, Thomas AU - Stroud, Rhonda AU - Taheri, Mitra AU - Tomeoka, Kazu AU - Toppani, Alice AU - Tsou, Peter AU - Tsuchiyama, Akira AU - Webber, Iris AU - Weisberg, Mike AU - Westphal, Andrew J AU - Yano, Hajime AU - Zega, Thomas AU - Anonymous Y1 - 2006 PY - 2006 DA - 2006 EP - unpaginated PB - Lunar and Planetary Science Conference, Houston, TX VL - 37 KW - methods KW - laboratory studies KW - mineral composition KW - comets KW - Stardust Mission KW - Wild Comet KW - nucleus KW - interplanetary dust KW - samples KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50274063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Mineralogy+and+petrology+of+comet+Wild2+nucleus+samples&rft.au=Zolensky%2C+Michael%3BBland%2C+Phil%3BBradley%2C+John%3BBrearley%2C+Adrian+J%3BBrennan%2C+Sean%3BBridges%2C+John%3BBrownlee%2C+Donald%3BButterworth%2C+Anna+L%3BDai%2C+Zurong%3BEbel%2C+Denton%3BGenge%2C+Matt%3BGounelle%2C+Matthieu%3BGraham%2C+Giles%3BGrossman%2C+Lawrence%3BHarvey%2C+Ralph+P%3BIshii%2C+Hope%3BKearsley%2C+Anton%3BKeller%2C+Lindsay%3BKrot%2C+Alexander+N%3BLanzirotti%2C+Antonio%3BLeroux%2C+Hugues%3BMessenger%2C+Keiko%3BMikouchi%2C+Takashi%3BNakamura%2C+Tomoki%3BOhsumi%2C+Kazumasa%3BOkudaira%2C+Kyoko%3BPerronnet%2C+Murielle%3BRietmeijer%2C+Frans%3BSimon%2C+Steven%3BStephan%2C+Thomas%3BStroud%2C+Rhonda%3BTaheri%2C+Mitra%3BTomeoka%2C+Kazu%3BToppani%2C+Alice%3BTsou%2C+Peter%3BTsuchiyama%2C+Akira%3BWebber%2C+Iris%3BWeisberg%2C+Mike%3BWestphal%2C+Andrew+J%3BYano%2C+Hajime%3BZega%2C+Thomas%3BAnonymous&rft.aulast=Zolensky&rft.aufirst=Michael&rft.date=2006-01-01&rft.volume=37&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.lpi.usra.edu/meetings/lpsc2006/pdf/1203.pdf LA - English DB - GeoRef N1 - Conference title - Thirty-seventh lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 2 N1 - PubXState - TX N1 - SuppNotes - Accessed on Dec. 8, 2006 N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - comets; interplanetary dust; laboratory studies; methods; mineral composition; nucleus; samples; Stardust Mission; Wild Comet ER - TY - JOUR T1 - Crystal structure of phosphatidylglycerophosphatase (PGPase), a putative membrane-bound lipid phosphatase, reveals a novel binuclear metal binding site and two "proton wires" AN - 21345633; 7014035 AB - Phosphatidylglycerophosphatase (PGPase), an enzyme involved in lipid metabolism, catalyzes formation of phosphatidylglycerol from phosphatidylglycerophosphate. Phosphatidylglycerol is a multifunctional phospholipid, found in the biological membranes of many organisms. Here, we report the crystal structure of Listeria monocytogenes PGPase at 1.8 Aa resolution. PGPase, an all-helical molecule, forms a homotetramer. Each protomer contains an independent active site with two metal ions, Ca super(2+) and Mg super(2+), forming a hetero-binuclear center located in a hydrophilic cavity near the surface of the molecule. The binuclear center, conserved ligands, metal-bound water molecules, and an Asp-His dyad form the active site. The catalytic mechanism of this enzyme is likely to proceed via binuclear metal activated nucleophilic water. The binuclear metal-binding active-site environment of this structure should provide insights into substrate binding and metal-dependent catalysis. A long channel with inter-linked linear water chains, termed "proton wires," is observed at the tetramer interface. Comparison of similar water chain structures in photosynthetic reaction centers (RCs), Cytochrome f, gramicidin, and bacteriorhodopsin, suggests that PGPase may conduct protons via proton wires. Proteins 2006. JF - Proteins: Structure, Function and Bioinformatics AU - Kumaran, Desigan AU - Bonanno, Jeffrey B AU - Burley, Stephen K AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York, swami@bnl.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 851 EP - 862 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 64 IS - 4 SN - 0887-3585, 0887-3585 KW - Microbiology Abstracts B: Bacteriology KW - binuclear metal site lipid metabolism phosphatase proton wires PGPase KW - Phosphatidylglycerophosphatase KW - Listeria monocytogenes KW - Cytochromes KW - Ions KW - Metals KW - Gramicidin KW - Calcium KW - Protons KW - phosphatidylglycerol KW - Enzymes KW - Lipid metabolism KW - Protein structure KW - Bacteriorhodopsin KW - Crystal structure KW - Bioinformatics KW - Magnesium KW - Phospholipids KW - Catalysis KW - Reaction centers KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21345633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+and+Bioinformatics&rft.atitle=Crystal+structure+of+phosphatidylglycerophosphatase+%28PGPase%29%2C+a+putative+membrane-bound+lipid+phosphatase%2C+reveals+a+novel+binuclear+metal+binding+site+and+two+%22proton+wires%22&rft.au=Kumaran%2C+Desigan%3BBonanno%2C+Jeffrey+B%3BBurley%2C+Stephen+K%3BSwaminathan%2C+Subramanyam&rft.aulast=Kumaran&rft.aufirst=Desigan&rft.date=2006-01-01&rft.volume=64&rft.issue=4&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+and+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.21039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Phosphatidylglycerophosphatase; Metals; Ions; Cytochromes; Gramicidin; Calcium; Protons; phosphatidylglycerol; Enzymes; Lipid metabolism; Protein structure; Bacteriorhodopsin; Crystal structure; Bioinformatics; Magnesium; Reaction centers; Catalysis; Phospholipids; Listeria monocytogenes DO - http://dx.doi.org/10.1002/prot.21039 ER - TY - JOUR T1 - MicroPET investigation of chronic long-term neurotoxicity from heavy ion irradiation AN - 21213711; 11177686 AB - Positron emission tomography (PET) permits imaging of the regional biodistribution and pharmacokinetics of compounds labeled with short-lived positron-emitting isotopes. It has enabled evaluation of neurochemical systems in the living human brain, including effects of toxic substances. MicroPET devices allos studies of the rat brain with a spatial resolution of ~2 mm. This is much poorer resolution than obtained using ex vivo autoradiography. However, animals need not be euthanized before imaging, so repeat studies are possible. This in principle allows the effects of toxic insults to be followed over the lifetime of an individual animal. We used microPET to evaluate brain metabolic effects of irradiation with high-energy heavy ions (HZE radiation), a component of the space radiation environment, on regional glucose metabolism. A significant fraction of neurons would be traversed by these densely ionizing particles during a Mars mission, and there is a need to estimate human neurological risks of prolonged voyages beyond the geomagnetosphere. Rats were irradiated withFe (600 MeV/n) ions at doses up to 240 cGy. At 9 months post-irradiation we did not detect alterations in regional accumulation of the glucose analog [F]2-deoxy-2-fluoro-D-glucose. This may indicate that damage to the brain from HZE particles is less severe than feared. However, because radiation-induced alterations in some behaviors have been documented, it may reflect insensitivity of baseline cerebral glucose metabolism to HZE radiation. These studies will facilitate design of future studies of chronic, long-term exposure to both therapeutic and abused drugs using microPET. JF - AAPS Journal AU - Rice, Onarae AU - Saintvictor, Sandra AU - Michaelides, Michael AU - Thanos, Panayotis AU - Gatley, Samuel John AD - Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY, s.gatley@neu.edu Y1 - 2006 PY - 2006 DA - 2006 SP - E508 EP - E514 PB - American Association of Pharmaceutical Scientists VL - 8 IS - 3 SN - 1550-7416, 1550-7416 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Ions KW - Isotopes KW - Neuroimaging KW - Brain injury KW - Brain KW - spatial discrimination KW - Glucose metabolism KW - Post-irradiation KW - Drug abuse KW - Autoradiography KW - Pharmacokinetics KW - Heavy ion radiation KW - Neurons KW - Neurotoxicity KW - Positron emission tomography KW - X 24390:Radioactive Materials KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21213711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=MicroPET+investigation+of+chronic+long-term+neurotoxicity+from+heavy+ion+irradiation&rft.au=Rice%2C+Onarae%3BSaintvictor%2C+Sandra%3BMichaelides%2C+Michael%3BThanos%2C+Panayotis%3BGatley%2C+Samuel+John&rft.aulast=Rice&rft.aufirst=Onarae&rft.date=2006-01-01&rft.volume=8&rft.issue=3&rft.spage=E508&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Faapsj080360 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Ions; Neuroimaging; Isotopes; Brain injury; Brain; spatial discrimination; Glucose metabolism; Autoradiography; Drug abuse; Post-irradiation; Pharmacokinetics; Heavy ion radiation; Neurons; Neurotoxicity; Positron emission tomography DO - http://dx.doi.org/10.1208/aapsj080360 ER - TY - JOUR T1 - Attribution of modeled atmospheric sulfate and SO sub(2) in the Northern Hemisphere for June-July 1997 AN - 20741294; 7260455 AB - Anthropogenic sulfate aerosol is a major contributor to shortwave radiative forcing of climate change by direct light scattering and by perturbing cloud properties and to local concentrations of atmospheric particulate matter. Here we analyze results from previously published calculations with an Eulerian transport model for atmospheric sulfur species in the Northern Hemisphere in June-July, 1997 to quantify the absolute and relative contributions of specific source regions (North America, Europe, and Asia) and SO sub(2)-to-sulfate conversion mechanisms (gas-phase, aqueous-phase and primary sulfate) to sulfate and SO sub(2) column burdens as a function of location and time. Although material emitted within a given region dominates the sulfate and SO sub(2) column burden in that region, examination of time series at specific locations shows that material imported from outside can make a substantial and occasionally dominant contribution. Frequently the major fraction of these exogenous contributions to the sulfate column burden was present aloft, thus minimally impacting air quality at the surface, but contributing substantially to the burden and, by implication, to radiative forcing and diminution of surface irradiance. Although the dominant sulfate formation pathway in the domain as a whole is aqueous-phase reaction in clouds (62%), in regions with minimum opportunity for aqueous-phase reaction gas-phase oxidation is dominant, albeit with considerable temporal variability depending on meteorological conditions. These calculations highlight the importance of transoceanic transport of sulfate, especially at the western margins of continents under the influence of predominantly westerly transport winds. JF - Atmospheric Chemistry and Physics AU - Benkovitz, C M AU - Schwartz, SE AU - Jensen, M P AU - Miller, MA AD - Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 4723 EP - 4738 PB - European Geophysical Society, Max-Planck-Str. 13 37191 Katlenburg-Lindau Germany, [mailto:egs@copernicus.org], [URL:http://www.copernicus.org/] VL - 6 IS - 12 SN - 1680-7316, 1680-7316 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Sulfates KW - Sulfur KW - Atmospheric pollution models KW - Sulfur in atmosphere KW - Climatic changes KW - Climate change KW - Westerlies KW - Light scattering KW - Europe KW - Air quality KW - Time series analysis KW - Sulfur dioxide KW - Radiative forcing KW - Cloud properties KW - Asia KW - Meteorological conditions KW - North America KW - Aerosols KW - Atmospheric pollution KW - Climate models KW - time series analysis KW - Sulfate formation KW - Sulfate aerosols KW - Clouds KW - Atmospheric chemistry KW - Oxidation KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20741294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Chemistry+and+Physics&rft.atitle=Attribution+of+modeled+atmospheric+sulfate+and+SO+sub%282%29+in+the+Northern+Hemisphere+for+June-July+1997&rft.au=Benkovitz%2C+C+M%3BSchwartz%2C+SE%3BJensen%2C+M+P%3BMiller%2C+MA&rft.aulast=Benkovitz&rft.aufirst=C&rft.date=2006-01-01&rft.volume=6&rft.issue=12&rft.spage=4723&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Chemistry+and+Physics&rft.issn=16807316&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution models; Climate models; Atmospheric pollution; Sulfur in atmosphere; Climate change; Light scattering; Westerlies; Sulfate formation; Air quality; Sulfate aerosols; Time series analysis; Clouds; Radiative forcing; Oxidation; Atmospheric chemistry; Cloud properties; Meteorological conditions; Sulfur; Sulfates; Aerosols; Sulfur dioxide; time series analysis; Climatic changes; North America; Europe; Asia ER - TY - JOUR T1 - Comment on "size distribution of sea-salt emissions as a function of relative humidity" AN - 19573983; 6929801 AB - Tropospheric NO sub(2) column densities over China simulated with a regional model using different emission inventory input are compared with Global Ozone Monitoring Experiment (GOME) satellite data. These emission inventories include (i) emission estimates for the year 1995 from the Emission Database for Global Atmospheric Research (EDGAR), (ii) regional emission inventory used in the Transport and Chemical Evolution over the Pacific (TRACE-P) program with emission estimates for the year 2000 and (iii) national emission inventory used in the Chinese Ozone Research Programme (CORP) with emission estimates for the year 1995. Model simulations were performed for a summertime period and the results under clear-sky conditions were selected for comparison with GOME data of the years 1996 and 2000. The model generally reproduces high tropospheric NO sub(2) column densities in polluted areas of China that have been observed by GOME. However, the model simulations do not agree with the GOME measurements in a quantitative sense for some regions. Region-to-region comparisons show that with all the emission inventories the model underestimates the tropospheric NO sub(2) column density in remote and rural areas of China. It is found that TRACE-P underestimates the tropospheric NO sub(2) column density in all the regions with respect to the GOME measurements (by more than 50%). CORP and EDGAR appear to behave well for the model simulations in the North of China (within 15% deviations), but poorer for the model simulations in other regions (within 30-80% deviations). Linear regressions were performed with the NO sub(2) column densities available from GOME, Y, and the model, X, of each grid cell in selected regions. For all the region of China, comparison statistics are Y=0.361xX+0.935 with r super(2)=0.360 and bias=-41% for EDGAR, Y=1.124xX+0.920 with r super(2)=0.472 and bias=-67% for TRACE-P, and Y=0.431xX+0.835 with r super(2)=0.509 and bias=-31% for CORP. JF - Atmospheric Environment AU - Lewis, Ernie R AU - Schwartz, Stephen E AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, NY 11973-5000, USA, Elewis@bnl.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 588 EP - 590 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 40 IS - 3 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Tropospheric NO sub(2) KW - Emission inventory KW - Regional model KW - Satellite data KW - Gome KW - China KW - Relative humidity KW - Pollution monitoring KW - Sea salt particle size distribution KW - Atmospheric pollution models KW - Nitrogen dioxide in troposphere KW - Humidity effects on aerosols KW - Remote sensing KW - Statistical analysis KW - Emission inventories KW - Project TRACE KW - Emissions KW - Emission measurements KW - Regression analysis KW - Ozone KW - Ozone research KW - Simulation KW - Troposphere KW - Humidity KW - Satellites KW - Global Ozone Monitoring Experiment (GOME) KW - Sea salt particles-atmospheric interaction KW - Numerical simulations KW - Regional-scale models KW - China, People's Rep. KW - Evolution KW - Rural areas KW - M2 551.571:Humidity (551.571) KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19573983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Comment+on+%22size+distribution+of+sea-salt+emissions+as+a+function+of+relative+humidity%22&rft.au=Lewis%2C+Ernie+R%3BSchwartz%2C+Stephen+E&rft.aulast=Lewis&rft.aufirst=Ernie&rft.date=2006-01-01&rft.volume=40&rft.issue=3&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2005.08.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Relative humidity; Sea salt particle size distribution; Nitrogen dioxide in troposphere; Atmospheric pollution models; Humidity effects on aerosols; Ozone research; Statistical analysis; Global Ozone Monitoring Experiment (GOME); Satellite data; Sea salt particles-atmospheric interaction; Numerical simulations; Regional-scale models; Project TRACE; Regression analysis; Evolution; Rural areas; Pollution monitoring; Emission inventories; Remote sensing; Emission measurements; Emissions; Humidity; Troposphere; Simulation; Satellites; Ozone; China, People's Rep. DO - http://dx.doi.org/10.1016/j.atmosenv.2005.08.043 ER - TY - JOUR T1 - Identification of amino acid residues involved in substrate specificity of plant acyl-ACP thioesterases using a bioinformatics-guided approach AN - 19449688; 7248491 AB - The large amount of available sequence information for the plant acyl-ACP thioesterases (TEs) made it possible to use a bioinformatics-guided approach to identify amino acid residues involved in substrate specificity. The Conserved Property Difference Locator (CPDL) program allowed the identification of putative specificity-determining residues that differ between the FatA and FatB te classes. Six of the FatA residue differences identified by CPDL were incorporated into the FatB-like parent via site-directed mutagenesis and the effect of each on te activity was determined. Variants were expressed in E. coli strain K27 that allows determination of enzyme activity by GCMS analysis of fatty acids released into the medium. Results Substitutions at four of the positions (74, 86, 141, and 174) changed substrate specificity to varying degrees while changes at the remaining two positions, 110 and 221, essentially inactivated the thioesterase. The effects of substitutions at positions 74, 141, and 174 (3-MUT) or 74, 86, 141, 174 (4-MUT) were not additive with respect to specificity. Conclusion Four of six putative specificity determining positions in plant TEs, identified with the use of CPDL, were validated experimentally; a novel colorimetric screen that discriminates between active and inactive TEs is also presented. JF - BMC Plant Biology AU - Mayer, Kimberly M AU - Shanklin, John AD - Brookhaven National Laboratory, Department of Biology, Upton, NY 11973 USA, mayerk@uncw.edu Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 6 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 1 KW - Site-directed mutagenesis KW - Amino acids KW - thioesterase KW - Escherichia coli KW - Fatty acids KW - Substrate specificity KW - Colorimetry KW - Enzymes KW - Amino acid sequence KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19449688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Plant+Biology&rft.atitle=Identification+of+amino+acid+residues+involved+in+substrate+specificity+of+plant+acyl-ACP+thioesterases+using+a+bioinformatics-guided+approach&rft.au=Mayer%2C+Kimberly+M%3BShanklin%2C+John&rft.aulast=Mayer&rft.aufirst=Kimberly&rft.date=2006-01-01&rft.volume=6&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Plant+Biology&rft.issn=1471-2229&rft_id=info:doi/10.1186%2F1471-2229-7-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Site-directed mutagenesis; Amino acids; thioesterase; Fatty acids; Enzymes; Colorimetry; Substrate specificity; Amino acid sequence; Escherichia coli DO - http://dx.doi.org/10.1186/1471-2229-7-1 ER - TY - JOUR T1 - Crystal structure of a putative HTH-type transcriptional regulator yxaF from Bacillus subtilis AN - 17170738; 6838764 JF - Proteins: Structure, Function & Bioinformatics AU - Seetharaman, Jayaraman AU - Kumaran, Desigan AU - Bonanno, Jeffrey B AU - Burley, Stephen K AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York, swami@bnl.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1087 EP - 1091 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 63 IS - 4 SN - 0887-3585, 0887-3585 KW - Microbiology Abstracts B: Bacteriology KW - Protein structure KW - Bacillus subtilis KW - Crystal structure KW - Transcription KW - Bioinformatics KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17170738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.atitle=Crystal+structure+of+a+putative+HTH-type+transcriptional+regulator+yxaF+from+Bacillus+subtilis&rft.au=Seetharaman%2C+Jayaraman%3BKumaran%2C+Desigan%3BBonanno%2C+Jeffrey+B%3BBurley%2C+Stephen+K%3BSwaminathan%2C+Subramanyam&rft.aulast=Seetharaman&rft.aufirst=Jayaraman&rft.date=2006-01-01&rft.volume=63&rft.issue=4&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.20924 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bacillus subtilis; Transcription; Protein structure; Bioinformatics; Crystal structure DO - http://dx.doi.org/10.1002/prot.20924 ER - TY - CPAPER T1 - Novel Radiolabeled Ligands Based on Adenoviral Sub-Unit Proteins for Molecular Imaging T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39816172; 4067555 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Srivastava, S C AU - Awasthi, V AU - Meinken, G AU - Springer, K AU - Freimuth, P Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Imaging techniques KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39816172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Novel+Radiolabeled+Ligands+Based+on+Adenoviral+Sub-Unit+Proteins+for+Molecular+Imaging&rft.au=Srivastava%2C+S+C%3BAwasthi%2C+V%3BMeinken%2C+G%3BSpringer%2C+K%3BFreimuth%2C+P&rft.aulast=Srivastava&rft.aufirst=S&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bone-Localizing Electron-Emitting Therapeutic Radiopharmaceuticals T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39807913; 4067390 DE: JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Srivastava, S C Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39807913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Bone-Localizing+Electron-Emitting+Therapeutic+Radiopharmaceuticals&rft.au=Srivastava%2C+S+C&rft.aulast=Srivastava&rft.aufirst=S&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbon-to-Metal Hydrogen Atom Transfers in the Formation of Metal Hydrides T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39806154; 4067386 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Bullock, M AU - Zhang, J AU - Grills, D C AU - Huang, K AU - Fujita, E Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Hydrogen KW - Metals KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Carbon-to-Metal+Hydrogen+Atom+Transfers+in+the+Formation+of+Metal+Hydrides&rft.au=Bullock%2C+M%3BZhang%2C+J%3BGrills%2C+D+C%3BHuang%2C+K%3BFujita%2C+E&rft.aulast=Bullock&rft.aufirst=M&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preparation of @@u88@Y from the Niobium Cladding of Proton Irradiated Gallium Target T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39806094; 4067366 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Mausner, L AU - Kurczak, S AU - Meinken, G Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Gallium KW - Niobium KW - Protons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Preparation+of+%40%40u88%40Y+from+the+Niobium+Cladding+of+Proton+Irradiated+Gallium+Target&rft.au=Mausner%2C+L%3BKurczak%2C+S%3BMeinken%2C+G&rft.aulast=Mausner&rft.aufirst=L&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Desulfurization Reactions on Metal Carbides and Phosphides: Complex Role of the Carbon and Phosphorus Sites T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39774261; 4062319 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Rodriguez, J A Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Phosphorus KW - Metals KW - Desulfurization KW - Carbon KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39774261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Desulfurization+Reactions+on+Metal+Carbides+and+Phosphides%3A+Complex+Role+of+the+Carbon+and+Phosphorus+Sites&rft.au=Rodriguez%2C+J+A&rft.aulast=Rodriguez&rft.aufirst=J&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemical Imaging of Biological Tissues Using a Combination of Synchrotron-Based Infrared and X-Ray Microscopy T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39764747; 4065734 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Miller, L AU - Smith, R AU - Wang, A AU - Lanzirotti, A AU - Warren, J Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Microscopy KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Chemical+Imaging+of+Biological+Tissues+Using+a+Combination+of+Synchrotron-Based+Infrared+and+X-Ray+Microscopy&rft.au=Miller%2C+L%3BSmith%2C+R%3BWang%2C+A%3BLanzirotti%2C+A%3BWarren%2C+J&rft.aulast=Miller&rft.aufirst=L&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photochemical Properties of Functionalized Polypyridylruthenium Complexes with a NAD+/NADH Model Ligand T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39760950; 4067145 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Fujita, E AU - Koizumi, T AU - Tanaka, K Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Photochemicals KW - Models KW - NADH KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39760950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Photochemical+Properties+of+Functionalized+Polypyridylruthenium+Complexes+with+a+NAD%2B%2FNADH+Model+Ligand&rft.au=Fujita%2C+E%3BKoizumi%2C+T%3BTanaka%2C+K&rft.aulast=Fujita&rft.aufirst=E&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Horizontal gene transfer to endogenous endophytic bacteria from poplar improves phytoremediation of toluene. AN - 68876308; 16332840 AB - Poplar, a plant species frequently used for phytoremediation of groundwater contaminated with organic solvents, was inoculated with the endophyte Burkholderia cepacia VM1468. This strain, whose natural host is yellow lupine, contains the pTOM-Bu61 plasmid coding for constitutively expressed toluene degradation. Noninoculated plants or plants inoculated with the soil bacterium B. cepacia Bu61(pTOM-Bu61) were used as controls. Inoculation of poplar had a positive effect on plant growth in the presence of toluene and reduced the amount of toluene released via evapotranspiration. These effects were more dramatic for VM1468, the endophytic strain, than for Bu61. Remarkably, none of the strains became established at detectable levels in the endophytic community, but there was horizontal gene transfer of pTOM-Bu61 to different members of the endogenous endophytic community, both in the presence and in the absence of toluene. This work is the first report of in planta horizontal gene transfer among plant-associated endophytic bacteria and demonstrates that such transfer could be used to change natural endophytic microbial communities in order to improve the remediation of environmental insults. JF - Applied and environmental microbiology AU - Taghavi, Safiyh AU - Barac, Tanja AU - Greenberg, Bill AU - Borremans, Brigitte AU - Vangronsveld, Jaco AU - van der Lelie, Daniel AD - Brookhaven National Laboratory, Biology Department, Building 463, Upton, NY 11973-5000. vdlelied@bnl.gov. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 8500 EP - 8505 VL - 71 IS - 12 SN - 0099-2240, 0099-2240 KW - DNA Primers KW - 0 KW - Toluene KW - 3FPU23BG52 KW - Index Medicus KW - Soil Microbiology KW - Polymerase Chain Reaction KW - Plant Stems -- microbiology KW - Plant Roots -- microbiology KW - Plant Leaves -- microbiology KW - Burkholderia cepacia -- metabolism KW - Burkholderia cepacia -- genetics KW - Toluene -- pharmacokinetics KW - Gene Transfer, Horizontal KW - Biodegradation, Environmental KW - Populus -- growth & development KW - Populus -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68876308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Horizontal+gene+transfer+to+endogenous+endophytic+bacteria+from+poplar+improves+phytoremediation+of+toluene.&rft.au=Taghavi%2C+Safiyh%3BBarac%2C+Tanja%3BGreenberg%2C+Bill%3BBorremans%2C+Brigitte%3BVangronsveld%2C+Jaco%3Bvan+der+Lelie%2C+Daniel&rft.aulast=Taghavi&rft.aufirst=Safiyh&rft.date=2005-12-01&rft.volume=71&rft.issue=12&rft.spage=8500&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-07 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Environ Microbiol. 2000 Jun;2(3):319-23 [11200433] Appl Environ Microbiol. 2001 Feb;67(2):1015-9 [11157282] Environ Sci Technol. 2001 Nov 1;35(21):446A-452A [11718366] Microbiology. 2002 Feb;148(Pt 2):341-3 [11832496] Environ Microbiol. 2002 Dec;4(12):799-808 [12534463] Nat Biotechnol. 2004 May;22(5):583-8 [15077119] Trends Biotechnol. 2005 Jan;23(1):6-8; discussion 8-9 [15629849] Appl Environ Microbiol. 1992 Dec;58(12):3977-83 [1282314] Microbiol Rev. 1995 Mar;59(1):143-69 [7535888] Appl Environ Microbiol. 1995 Apr;61(4):1352-6 [7538275] Appl Environ Microbiol. 1998 Jun;64(6):2096-104 [9603820] Environ Microbiol. 2004 Dec;6(12):1244-51 [15560822] Adv Appl Microbiol. 2004;56:291-312 [15566983] J Bacteriol. 1985 Apr;162(1):328-34 [3884593] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Effect of water on compressibility of San Carlos Olivine and its implications AN - 50458382; 2009-073500 JF - Eos, Transactions, American Geophysical Union AU - Chen, J AU - Liu, H AU - Yu, T AU - Hu, J AU - Anonymous Y1 - 2005/12// PY - 2005 DA - December 2005 SP - Abstract MR41A EP - 0897 PB - American Geophysical Union, Washington, DC VL - 86 IS - 52, SUPPL. SN - 0096-3941, 0096-3941 KW - water KW - silicates KW - upper mantle KW - experimental studies KW - mantle KW - olivine group KW - elastic constants KW - bulk modulus KW - San Carlos Olivine KW - nesosilicates KW - physical properties KW - wadsleyite KW - orthosilicates KW - equations of state KW - anvil cells KW - P-T conditions KW - compressibility KW - 17B:Geophysics of minerals and rocks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50458382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Effect+of+water+on+compressibility+of+San+Carlos+Olivine+and+its+implications&rft.au=Chen%2C+J%3BLiu%2C+H%3BYu%2C+T%3BHu%2C+J%3BAnonymous&rft.aulast=Chen&rft.aufirst=J&rft.date=2005-12-01&rft.volume=86&rft.issue=52%2C+SUPPL.&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2005 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - anvil cells; bulk modulus; compressibility; elastic constants; equations of state; experimental studies; mantle; nesosilicates; olivine group; orthosilicates; P-T conditions; physical properties; San Carlos Olivine; silicates; upper mantle; wadsleyite; water ER - TY - JOUR T1 - Flow banding in rhyolites; a manifestation of water concentration heterogeneity in the melt? AN - 50429743; 2009-043300 JF - Eos, Transactions, American Geophysical Union AU - Seaman, S J AU - Dyar, D AU - Marinkovic, N AU - Anonymous Y1 - 2005/12// PY - 2005 DA - December 2005 SP - Abstract V41I EP - 05 PB - American Geophysical Union, Washington, DC VL - 86 IS - 52, SUPPL. SN - 0096-3941, 0096-3941 KW - water KW - United States KW - silicates KW - concentration KW - rhyolites KW - volcanic rocks KW - lava flows KW - gaseous phase KW - igneous rocks KW - Atascosa Mountains KW - southern Arizona KW - melts KW - infrared spectra KW - FTIR spectra KW - mineral composition KW - magmas KW - spherulites KW - Arizona KW - crystallization KW - framework silicates KW - spectra KW - heterogeneity KW - feldspar group KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50429743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Melanoma&rft.atitle=Data+Supporting+an+Important+Role+for+Wavelengths+Greater+than+UVB+in+Inducing+Melanomas&rft.au=Setlow%2C+R&rft.aulast=Setlow&rft.aufirst=R&rft.date=2005-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Melanoma&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2005 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Arizona; Atascosa Mountains; concentration; crystallization; feldspar group; framework silicates; FTIR spectra; gaseous phase; heterogeneity; igneous rocks; infrared spectra; lava flows; magmas; melts; mineral composition; rhyolites; silicates; southern Arizona; spectra; spherulites; United States; volcanic rocks; water ER - TY - CPAPER T1 - Effects of Anesthesia on NMDA Receptor Open - Channel Density in Amyloid - b Overproducing and Wild - Type Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39998712; 4133950 JF - 35th Annual Meeting of the Society for Neuroscience AU - Biegon, A AU - Pareto, D AU - Guol, J AU - Kofke, W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Channels KW - Mice KW - Anesthesia KW - Glutamic acid receptors KW - B-Amyloid KW - N-Methyl-D-aspartic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39998712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Anesthesia+on+NMDA+Receptor+Open+-+Channel+Density+in+Amyloid+-+b+Overproducing+and+Wild+-+Type+Mice&rft.au=Biegon%2C+A%3BPareto%2C+D%3BGuol%2C+J%3BKofke%2C+W&rft.aulast=Biegon&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Food Restriction in Female Rats Increased Conditioned Place Preference for Food Compared to Cocaine T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39992302; 4121742 JF - 35th Annual Meeting of the Society for Neuroscience AU - Barbarich-Marsteller, N C AU - Marsteller, D A AU - Fowler, J S AU - Dewey, S L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Rats KW - Food preferences KW - Cocaine KW - Food availability KW - Place preferences KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39992302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Chronic+Food+Restriction+in+Female+Rats+Increased+Conditioned+Place+Preference+for+Food+Compared+to+Cocaine&rft.au=Barbarich-Marsteller%2C+N+C%3BMarsteller%2C+D+A%3BFowler%2C+J+S%3BDewey%2C+S+L&rft.aulast=Barbarich-Marsteller&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Morris Water Maze Data from HVS Running Systems Using Microsoft Excel and Sigma Stat T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39983507; 4130335 JF - 35th Annual Meeting of the Society for Neuroscience AU - Flavin, N J AU - Neill, J C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Running KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39983507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Analysis+of+Morris+Water+Maze+Data+from+HVS+Running+Systems+Using+Microsoft+Excel+and+Sigma+Stat&rft.au=Flavin%2C+N+J%3BNeill%2C+J+C&rft.aulast=Flavin&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optical Brain Monitoring of Cerebrovascular and Intracellular Calcium Effects Induced by Acute Cocaine Exposure in the Living Rat T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39980307; 4133704 JF - 35th Annual Meeting of the Society for Neuroscience AU - Du, C. AU - Thanos, P K AU - Yu, M. AU - Rivera, S AU - Benveniste, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Calcium (intracellular) KW - Brain KW - Cocaine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39980307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Optical+Brain+Monitoring+of+Cerebrovascular+and+Intracellular+Calcium+Effects+Induced+by+Acute+Cocaine+Exposure+in+the+Living+Rat&rft.au=Du%2C+C.%3BThanos%2C+P+K%3BYu%2C+M.%3BRivera%2C+S%3BBenveniste%2C+H&rft.aulast=Du&rft.aufirst=C.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Changes in NMDA Receptor Activation Following Intracranial Surgery: [11C]CNS5161 microPET Studies T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39925460; 4133953 JF - 35th Annual Meeting of the Society for Neuroscience AU - Schiffer, W K AU - Alexoff, D AU - Dewey, S L AU - Ding, Y AU - Gibbs, A R AU - Lin, K AU - Pareto, D AU - Wu, H. AU - Biegon, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Surgery KW - Glutamic acid receptors KW - Receptor mechanisms KW - N-Methyl-D-aspartic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dynamic+Changes+in+NMDA+Receptor+Activation+Following+Intracranial+Surgery%3A+%5B11C%5DCNS5161+microPET+Studies&rft.au=Schiffer%2C+W+K%3BAlexoff%2C+D%3BDewey%2C+S+L%3BDing%2C+Y%3BGibbs%2C+A+R%3BLin%2C+K%3BPareto%2C+D%3BWu%2C+H.%3BBiegon%2C+A&rft.aulast=Schiffer&rft.aufirst=W&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Administration of Cocaine in DAT Mice: Effect on Cerebral Glucose Metabolism Using mPET T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39923210; 4132012 JF - 35th Annual Meeting of the Society for Neuroscience AU - Rivera, S N AU - Caron, M G AU - Volkow, N D AU - Thanos, P K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glucose metabolism KW - Mice KW - Cocaine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Acute+Administration+of+Cocaine+in+DAT+Mice%3A+Effect+on+Cerebral+Glucose+Metabolism+Using+mPET&rft.au=Rivera%2C+S+N%3BCaron%2C+M+G%3BVolkow%2C+N+D%3BThanos%2C+P+K&rft.aulast=Rivera&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Monetary Reward on Event - Related Potentials in Cocaine Addiction T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39895977; 4128110 JF - 35th Annual Meeting of the Society for Neuroscience AU - Cottone, L A AU - Maloney, T AU - Delosh, D AU - Leskovjan, A AU - Alia-Klein, N AU - Telang, F AU - Squires, N K AU - Fowler, J S AU - Volkow, N D AU - Goldstein, R Z Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Economics KW - Addiction KW - Reinforcement KW - Cocaine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Effect+of+Monetary+Reward+on+Event+-+Related+Potentials+in+Cocaine+Addiction&rft.au=Cottone%2C+L+A%3BMaloney%2C+T%3BDelosh%2C+D%3BLeskovjan%2C+A%3BAlia-Klein%2C+N%3BTelang%2C+F%3BSquires%2C+N+K%3BFowler%2C+J+S%3BVolkow%2C+N+D%3BGoldstein%2C+R+Z&rft.aulast=Cottone&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracranial Surgery Results in Long Term Changes in NMDA and Peripheral Benzodiazepine Receptor Density in Rat Brain T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39890143; 4133952 JF - 35th Annual Meeting of the Society for Neuroscience AU - Tsabari, R AU - Schiffer, W K AU - Biegon, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Surgery KW - Brain KW - Benzodiazepine receptors KW - Receptor density KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39890143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Fabric+and+uranyl+retention+of+neomorphosed+aragonite+botryoids%3B+constraints+on+the+diagenetic+process&rft.au=Rasbury%2C+E+Troy%3BWard%2C+W+Bruce%3BNorthrup%2C+Paul+A%3BAnonymous&rft.aulast=Rasbury&rft.aufirst=E&rft.date=2005-10-01&rft.volume=37&rft.issue=7&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping Functional Neural Pathways in the Rat Brain Using [18F]Fluorodeoxyglucose and Intracranial Electrical Stimulation T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39884401; 4126951 JF - 35th Annual Meeting of the Society for Neuroscience AU - Dhawan, J AU - Kandrapa, S AU - Gifford, A N Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain mapping KW - Electrical stimuli KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39884401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Mapping+Functional+Neural+Pathways+in+the+Rat+Brain+Using+%5B18F%5DFluorodeoxyglucose+and+Intracranial+Electrical+Stimulation&rft.au=Dhawan%2C+J%3BKandrapa%2C+S%3BGifford%2C+A+N&rft.aulast=Dhawan&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Age - Related Changes of Striatal Dopamine D@@d2@ Receptor (D@@d2@R) Binding in Obese (fa/fa) and Lean (Le) Zucker Rats Revealed by Positron Emission Tomography (PET) T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39883885; 4126828 JF - 35th Annual Meeting of the Society for Neuroscience AU - Michaelides, M E AU - Thanos, P K AU - Rivera, S N AU - Wang, G AU - Volkow, N D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Rats KW - Positron emission tomography KW - Neostriatum KW - Dopamine D2 receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Age+-+Related+Changes+of+Striatal+Dopamine+D%40%40d2%40+Receptor+%28D%40%40d2%40R%29+Binding+in+Obese+%28fa%2Ffa%29+and+Lean+%28Le%29+Zucker+Rats+Revealed+by+Positron+Emission+Tomography+%28PET%29&rft.au=Michaelides%2C+M+E%3BThanos%2C+P+K%3BRivera%2C+S+N%3BWang%2C+G%3BVolkow%2C+N+D&rft.aulast=Michaelides&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measure of Induced Changes in Neurotransmitter and Glucose Metabolism During Chronic Citalopram Infusion T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39874733; 4126758 JF - 35th Annual Meeting of the Society for Neuroscience AU - Marsteller, D A AU - Patel, V D AU - Barbarich-Marsteller, N C AU - Dewey, S L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glucose metabolism KW - Neurotransmitters KW - Citalopram KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39874733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Measure+of+Induced+Changes+in+Neurotransmitter+and+Glucose+Metabolism+During+Chronic+Citalopram+Infusion&rft.au=Marsteller%2C+D+A%3BPatel%2C+V+D%3BBarbarich-Marsteller%2C+N+C%3BDewey%2C+S+L&rft.aulast=Marsteller&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time - Course Changes of Dopamine D@@d2@ and CB1 Cannabinoid Receptors During Cocaine Self - Administration T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39872810; 4128482 JF - 35th Annual Meeting of the Society for Neuroscience AU - Thanos, P K AU - Soria, L AU - Michaelides, M E AU - Piyis, Y K AU - Pappas, G P AU - Maldonado, R AU - Valverde, O AU - Volkow, N D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cocaine KW - Cannabinoid CB1 receptors KW - Dopamine D2 receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39872810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Time+-+Course+Changes+of+Dopamine+D%40%40d2%40+and+CB1+Cannabinoid+Receptors+During+Cocaine+Self+-+Administration&rft.au=Thanos%2C+P+K%3BSoria%2C+L%3BMichaelides%2C+M+E%3BPiyis%2C+Y+K%3BPappas%2C+G+P%3BMaldonado%2C+R%3BValverde%2C+O%3BVolkow%2C+N+D&rft.aulast=Thanos&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long - term Effects of Whole - brain Irradiation on Auditory Discrimination T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39870042; 4129068 JF - 35th Annual Meeting of the Society for Neuroscience AU - Aubele, T M AU - Kristiansen, R AU - Murphy, M AU - Rice, O AU - Gately, S J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Irradiation KW - Radiation KW - Auditory discrimination KW - Abiotic factors KW - Light effects KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Long+-+term+Effects+of+Whole+-+brain+Irradiation+on+Auditory+Discrimination&rft.au=Aubele%2C+T+M%3BKristiansen%2C+R%3BMurphy%2C+M%3BRice%2C+O%3BGately%2C+S+J&rft.aulast=Aubele&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Aging and Seizures on Auditory Discrimination T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39860955; 4119073 JF - 35th Annual Meeting of the Society for Neuroscience AU - Neill, J C AU - Holmes, G L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Aging KW - Auditory discrimination KW - Seizures KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Aging+and+Seizures+on+Auditory+Discrimination&rft.au=Neill%2C+J+C%3BHolmes%2C+G+L&rft.aulast=Neill&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Methylphenidate and Amphetamineon Locomotor Activity and Conditioned Place Preference in Dopamine D@@d4R@ Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39827089; 4123479 JF - 35th Annual Meeting of the Society for Neuroscience AU - Vavilis, G N AU - Grandy, D AU - Suchland, K AU - Rubinstein, M AU - Volkow, N D AU - Thanos, P K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Methylphenidate KW - Dopamine D4 receptors KW - Locomotor activity KW - Place preferences KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39827089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Methylphenidate+and+Amphetamineon+Locomotor+Activity+and+Conditioned+Place+Preference+in+Dopamine+D%40%40d4R%40+Mice&rft.au=Vavilis%2C+G+N%3BGrandy%2C+D%3BSuchland%2C+K%3BRubinstein%2C+M%3BVolkow%2C+N+D%3BThanos%2C+P+K&rft.aulast=Vavilis&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Cognitive Functioning and Recent Cocaine Use: Evidence from Neuropsychological Testing and Urine Toxicology T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39817688; 4126795 JF - 35th Annual Meeting of the Society for Neuroscience AU - Goldstein, R Z AU - Delosh, D AU - Cottone, L A AU - Leskovjan, A AU - Alia-Klein, N AU - Fowler, J S AU - Wang, G AU - Telang, F AU - Maloney, T AU - Volkow, N D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Urine KW - Cocaine KW - Cognitive ability KW - Toxicology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39817688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Relationship+between+Cognitive+Functioning+and+Recent+Cocaine+Use%3A+Evidence+from+Neuropsychological+Testing+and+Urine+Toxicology&rft.au=Goldstein%2C+R+Z%3BDelosh%2C+D%3BCottone%2C+L+A%3BLeskovjan%2C+A%3BAlia-Klein%2C+N%3BFowler%2C+J+S%3BWang%2C+G%3BTelang%2C+F%3BMaloney%2C+T%3BVolkow%2C+N+D&rft.aulast=Goldstein&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Acute Methylphenidate on Condition Position Responding ( Visual Position Discrimination ) in SHR and WKY Rats T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39797679; 4131934 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pena, L A AU - Reiszel, C AU - Drepanis, A D AU - Volkow, N D AU - Thanos, P K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Rats KW - Methylphenidate KW - Visual discrimination KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39797679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Effects+of+Acute+Methylphenidate+on+Condition+Position+Responding+%28+Visual+Position+Discrimination+%29+in+SHR+and+WKY+Rats&rft.au=Pena%2C+L+A%3BReiszel%2C+C%3BDrepanis%2C+A+D%3BVolkow%2C+N+D%3BThanos%2C+P+K&rft.aulast=Pena&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Mechanisms of uranium mineralization by the yeast Saccharomyces cerevisiae AN - 51602645; 2006-030861 AB - We determined the association of uranium in yeast cells S. cerevisiae grown in medium containing high (1 g.L (super -1) ) or low (0.2 g.L (super -1) ) concentrations of phosphate after exposure for 96 h to a 4 X 10 (super -4) mol.L (super -1) U(VI) solution at pH 3.2 or 4.7. The analysis was made using a field emission scanning electron microscope equipped with energy dispersive spectroscopy (FESEM-EDS), transmission electron microscopy (TEM), and visible diffuse reflectance spectrometry. Cells grown in the high-phosphate medium rapidly accumulated U(VI) from solution at pH 3.2 over the first 24 h, followed by a slow uptake until 96 h, whereas in cells grown in low-phosphate medium, U(VI) accumulation reached a steady state within 24 h. FESEM-EDS analyses revealed the formation of a U(VI)-bearing precipitate on the yeast cells grown in high-phosphate medium after only 48 h exposure; no precipitate was detected on cells grown in low-phosphate medium up to 96 h. These results suggest that sorption onto the cell surfaces was the dominant process initially. Analysis of the U(VI)-bearing precipitates by all three methods demonstrated the presence of H-autunite, HUO (sub 2) PO (sub 4) .4H (sub 2) O. Thermodynamic calculations suggest that the chemical compositions of the solutions containing yeast grown in high-phosphate medium were undersaturated with respect to H-autunite, but were supersaturated with ten times more U(VI) and P than were actually observed. Apparently, the sorbed U(VI) on the cell surfaces reacts with P released from the yeast to form H-autunite by local saturation. The U(VI) uptake by yeast cells grown in high phosphate medium at pH 4.7, along with the thermodynamic calculation, indicated that more H-autunite is precipitated in neutral pH solution than in acid solution. Thus, U(VI)-phosphate mineralization on the cells of microorganisms should be taken into account for predicting U(VI) mobility in the environment. JF - Geochimica et Cosmochimica Acta AU - Ohnuki, Toshihiko AU - Ozaki, T AU - Yoshida, T AU - Sakamoto, F AU - Kozai, N AU - Wakai, E AU - Francis, A J AU - Iefuji, H Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 5307 EP - 5316 PB - Pergamon, Oxford VL - 69 IS - 22 SN - 0016-7037, 0016-7037 KW - mineral deposits, genesis KW - autunite KW - mass spectra KW - aqueous solutions KW - metallogeny KW - mineralization KW - acidic composition KW - spectra KW - thermodynamic properties KW - geochemistry KW - Bacillus KW - pH KW - phosphates KW - TEM data KW - Saccharomyces cerevisiae KW - ICP mass spectra KW - uranium ores KW - biogenic processes KW - precipitation KW - bacteria KW - metal ores KW - mobilization KW - SEM data KW - microorganisms KW - 02C:Geochemistry of rocks, soils, and sediments KW - 27A:Economic geology, geology of ore deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51602645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Mechanisms+of+uranium+mineralization+by+the+yeast+Saccharomyces+cerevisiae&rft.au=Ohnuki%2C+Toshihiko%3BOzaki%2C+T%3BYoshida%2C+T%3BSakamoto%2C+F%3BKozai%2C+N%3BWakai%2C+E%3BFrancis%2C+A+J%3BIefuji%2C+H&rft.aulast=Ohnuki&rft.aufirst=Toshihiko&rft.date=2005-11-01&rft.volume=69&rft.issue=22&rft.spage=5307&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2Fj.gca.2005.06.023 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2006-01-01 N1 - Number of references - 39 N1 - Document feature - illus. incl. 1 plate N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - acidic composition; aqueous solutions; autunite; Bacillus; bacteria; biogenic processes; geochemistry; ICP mass spectra; mass spectra; metal ores; metallogeny; microorganisms; mineral deposits, genesis; mineralization; mobilization; pH; phosphates; precipitation; Saccharomyces cerevisiae; SEM data; spectra; TEM data; thermodynamic properties; uranium ores DO - http://dx.doi.org/10.1016/j.gca.2005.06.023 ER - TY - JOUR T1 - Magnetic field shift due to mechanical vibration in functional magnetic resonance imaging AN - 20859656; 8367947 AB - Mechanical vibrations of the gradient coil system during readout in echo-planar imaging (EPI) can increase the temperature of the gradient system and alter the magnetic field distribution during functional magnetic resonance imaging (fMRI). This effect is enhanced by resonant modes of vibrations and results in apparent motion along the phase encoding direction in fMRI studies. The magnetic field drift was quantified during EPI by monitoring the resonance frequency interleaved with the EPI acquisition, and a novel method is proposed to correct the apparent motion. The knowledge on the frequency drift over time was used to correct the phase of the k-space EPI dataset. Since the resonance frequency changes very slowly over time, two measurements of the resonance frequency, immediately before and after the EPI acquisition, are sufficient to remove the field drift effects from fMRI time series. The frequency drift correction method was tested in vivo and compared to the standard image realignment method. The proposed method efficiently corrects spurious motion due to magnetic field drifts during fMRI. JF - Magnetic Resonance in Medicine AU - Foerster, Bernd U AU - Tomasi, Dardo AU - Caparelli, Elisabeth C AD - Medical Department, Brookhaven National Laboratory, Upton, New York, USA, bfoerster@bnl.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1261 EP - 1267 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Vibrations KW - Magnetic fields KW - Drift KW - Functional magnetic resonance imaging KW - Magnetic resonance imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Magnetic+field+shift+due+to+mechanical+vibration+in+functional+magnetic+resonance+imaging&rft.au=Foerster%2C+Bernd+U%3BTomasi%2C+Dardo%3BCaparelli%2C+Elisabeth+C&rft.aulast=Foerster&rft.aufirst=Bernd&rft.date=2005-11-01&rft.volume=54&rft.issue=5&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20695 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Drift; Magnetic fields; Vibrations; Temperature effects; Magnetic resonance imaging DO - http://dx.doi.org/10.1002/mrm.20695 ER - TY - JOUR T1 - Can Motion Artifacts be Completely Removed from fMRI-Activation Maps? AN - 20642166; 7724341 AB - Most functional magnetic resonance imaging (fMRI) studies are based on the detection of small timedependent signal variation induced by changes in blood oxygenation during brain activation. However, since this signal change is very small (typically 1-5%; even under optimal conditions and high magnetic field strengths), head motion as small as 1 mm translation or 1 degree rotation, can also produce spurious activation, if correlated with the stimulus paradigm. Several methods have been proposed to retrospectively (during image post-processing) or prospectively (in real time) correct for motion, however these techniques generally correct only for geometric rigid- body effects. Head motion can also change the magnetic field homogeneity, altering the effective relaxation rates of tissues (R2'), and producing timedependent geometrical distortions in fMRI studies. Unfortunately these non-linear motion-related artifacts become worse at high field strengths and cannot be corrected by standard image realignment methods; therefore, the range of motion is restricted for in vivo fMRI studies, especially at high field strengths. Real-time motion monitoring during fMRI can provide highly accurate information on whether subject motion during an fMRI scan was acceptable or excessive, and whether repeat scans with excessive motion are necessary. JF - Current Medical Imaging Reviews AU - Caparelli, Elisabeth DC AD - Brookhaven National Laboratory, Medical Dept., Bldg. 490, Upton, NY 11973, USA. Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 253 EP - 264 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 1 IS - 3 SN - 1573-4056, 1573-4056 KW - Biotechnology and Bioengineering Abstracts KW - fmri KW - brain movement KW - motion detector KW - motion artifacts KW - motion correction KW - spurious activation KW - Magnetic fields KW - Translation KW - Blood KW - Brain mapping KW - Neuroimaging KW - Functional magnetic resonance imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20642166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Medical+Imaging+Reviews&rft.atitle=Can+Motion+Artifacts+be+Completely+Removed+from+fMRI-Activation+Maps%3F&rft.au=Caparelli%2C+Elisabeth+DC&rft.aulast=Caparelli&rft.aufirst=Elisabeth&rft.date=2005-11-01&rft.volume=1&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Current+Medical+Imaging+Reviews&rft.issn=15734056&rft_id=info:doi/10.2174%2F157340505774574727 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Brain mapping; Blood; Translation; Magnetic fields; Neuroimaging; Functional magnetic resonance imaging DO - http://dx.doi.org/10.2174/157340505774574727 ER - TY - JOUR T1 - Translational Neuroimaging: Positron Emission Tomography Studies of Monoamine Oxidase AN - 17107384; 6737092 AB - Positron emission tomography (PET) using radiotracers with high molecular specificity is an important scientific tool in studies of monoamine oxidase (MAO), an important enzyme in the regulation of the neurotransmitters dopamine, norepinephrine, and serotonin as well as the dietary amine, tyramine. MAO occurs in two different subtypes, MAO A and MAO B, which have different substrate and inhibitor specificity and which are different gene products. The highly variable subtype distribution with different species makes human studies of special value. MAO A and B can be imaged in the human brain and certain peripheral organs using PET and carbon-11 (half-life 20.4 minutes) labeled mechanism-based irreversible inhibitors, clorgyline and L-deprenyl, respectively. In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs. JF - Molecular Imaging and Biology AU - Fowler, J S AU - Logan, J AU - Volkow, N D AU - Wang, G-J AD - Brookhaven National Laboratory, Upton, NY 11973, USA, fowler@bnl.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 377 EP - 387 VL - 7 IS - 6 SN - 1536-1632, 1536-1632 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Translation KW - Neuroimaging KW - L-deprenyl KW - Amine oxidase (flavin-containing) KW - Enzymes KW - Serotonin KW - amines KW - Dopamine KW - Norepinephrine KW - Positron emission tomography KW - Neurotransmitters KW - tyramine KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17107384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Imaging+and+Biology&rft.atitle=Translational+Neuroimaging%3A+Positron+Emission+Tomography+Studies+of+Monoamine+Oxidase&rft.au=Fowler%2C+J+S%3BLogan%2C+J%3BVolkow%2C+N+D%3BWang%2C+G-J&rft.aulast=Fowler&rft.aufirst=J&rft.date=2005-11-01&rft.volume=7&rft.issue=6&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Molecular+Imaging+and+Biology&rft.issn=15361632&rft_id=info:doi/10.1007%2Fs11307-005-0016-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Amine oxidase (flavin-containing); Positron emission tomography; Translation; Neuroimaging; tyramine; Norepinephrine; Serotonin; Neurotransmitters; Dopamine; L-deprenyl; amines; Enzymes DO - http://dx.doi.org/10.1007/s11307-005-0016-1 ER - TY - JOUR T1 - Catalysts for hydrogen evolution from the [NiFe] hydrogenase to the Ni2P(001) surface: the importance of ensemble effect. AN - 68701791; 16231942 AB - Density functional theory (DFT) was employed to investigate the behavior of a series of catalysts used in the hydrogen evolution reaction (HER, 2H(+) + 2e(-) --> H(2)). The kinetics of the HER was studied on the [NiFe] hydrogenase, the [Ni(PS3*)(CO)](1)(-) and [Ni(PNP)(2)](2+) complexes, and surfaces such as Ni(111), Pt(111), or Ni(2)P(001). Our results show that the [NiFe] hydrogenase exhibits the highest activity toward the HER, followed by [Ni(PNP)(2)](2+) > Ni(2)P > [Ni(PS3*)(CO)](1)(-) > Pt > Ni in a decreasing sequence. The slow kinetics of the HER on the surfaces is due to the fact that the metal hollow sites bond hydrogen too strongly to allow the facile removal of H(2). In fact, the strong H-Ni interaction on Ni(2)P(001) can lead to poisoning of the highly active sites of the surface, which enhances the rate of the HER and makes it comparable to that of the [NiFe] hydrogenase. In contrast, the promotional effect of H-poisoning on the HER on Pt and Ni surfaces is relatively small. Our calculations suggest that among all of the systems investigated, Ni(2)P should be the best practical catalyst for the HER, combining the high thermostability of the surfaces and high catalytic activity of the [NiFe] hydrogenase. The good behavior of Ni(2)P(001) toward the HER is found to be associated with an ensemble effect, where the number of active Ni sites is decreased due to presence of P, which leads to moderate bonding of the intermediates and products with the surface. In addition, the P sites are not simple spectators and directly participate in the HER. JF - Journal of the American Chemical Society AU - Liu, Ping AU - Rodriguez, José A AD - Department of Chemistry, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2005/10/26/ PY - 2005 DA - 2005 Oct 26 SP - 14871 EP - 14878 VL - 127 IS - 42 SN - 0002-7863, 0002-7863 KW - Organometallic Compounds KW - 0 KW - Nickel KW - 7OV03QG267 KW - Hydrogen KW - 7YNJ3PO35Z KW - nickel-iron hydrogenase KW - EC 1.12.- KW - Hydrogenase KW - EC 1.12.7.2 KW - Index Medicus KW - Kinetics KW - Models, Chemical KW - Surface Properties KW - Organometallic Compounds -- chemistry KW - Catalysis KW - Hydrogen -- chemistry KW - Nickel -- chemistry KW - Hydrogenase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68701791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Catalysts+for+hydrogen+evolution+from+the+%5BNiFe%5D+hydrogenase+to+the+Ni2P%28001%29+surface%3A+the+importance+of+ensemble+effect.&rft.au=Liu%2C+Ping%3BRodriguez%2C+Jos%C3%A9+A&rft.aulast=Liu&rft.aufirst=Ping&rft.date=2005-10-26&rft.volume=127&rft.issue=42&rft.spage=14871&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=00027863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-10-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Selective Metal Binding to a Membrane-embedded Aspartate in the Escherichia coli Metal Transporter YiiP (FieF) AN - 17665736; 6503318 AB - The cation diffusion facilitators (CDF) are a ubiquitous family of metal transporters that play important roles in homeostasis of a wide range of divalent metal cations. Molecular identities of substrate-binding sites and their metal selectivity in the CDF family are thus far unknown. By using isothermal titration calorimetry and stopped-flow spectrofluorometry, we directly examined metal binding to a highly conserved aspartate in the Escherichia coli CDF transporter YiiP (FieF). A D157A mutation abolished a Cd super(2+)-binding site and impaired the corresponding Cd super(2+) transport. In contrast, substitution of Asp-157 with a cysteinyl coordination residue resulted in intact Cd super(2+) binding as well as full transport activity. A similar correlation was found for Zn super(2+) binding and transport, suggesting that Asp-157 is a metal coordination residue required for binding and transport of Cd super(2+) and Zn super(2+). The location of Asp-157 was mapped topologically to the hydrophobic core of transmembrane segment 5 (TM-5) where D157C was found partially accessible to thiol-specific labeling of maleimide polyethylene-oxide biotin. Binding of Zn super(2+) and Cd super(2+), but not Fe super(2+), Hg super(2+), Co super(2+), Ni super(2+), Mn super(2+), Ca super(2+), and Mg super(2+), protected D157C from maleimide polyethylene-oxide biotin labeling in a concentration-dependent manner. Furthermore, isothermal titration calorimetry analysis of YiiP sub(D157A) showed no detectable change in Fe super(2+) and Hg super(2+) calorimetric titrations, indicating that Asp-157 is not a coordination residue for Fe super(2+) and Hg super(2+) binding. Our results provided direct evidence for selective binding of Zn super(2+) and Cd super(2+) for to the highly conserved Asp-157 and defined its functional role in metal transport. JF - Journal of Biological Chemistry AU - Wei, Yinan AU - Fu, Dax AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973 Y1 - 2005/10/07/ PY - 2005 DA - 2005 Oct 07 SP - 33716 EP - 33724 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 40 SN - 0021-9258, 0021-9258 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - G 07320:Bacterial genetics KW - J 02723:Photosynthesis, electron transport and related phenomena UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17665736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Selective+Metal+Binding+to+a+Membrane-embedded+Aspartate+in+the+Escherichia+coli+Metal+Transporter+YiiP+%28FieF%29&rft.au=Wei%2C+Yinan%3BFu%2C+Dax&rft.aulast=Wei&rft.aufirst=Elisabeth&rft.date=2005-11-01&rft.volume=1&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Current+Medical+Imaging+Reviews&rft.issn=15734056&rft_id=info:doi/10.2174%2F157340505774574727 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Induction of anchorage-independent growth in primary human cells exposed to protons or HZE ions separately or in dual exposures. AN - 68634651; 16187755 AB - Travelers on space missions will be exposed to a complex radiation environment that includes protons and heavy charged particles. Since protons are present at much higher levels than are heavy ions, the most likely scenario for cellular radiation exposure will be proton exposure followed by a hit by a heavy ion. Although the effects of individual ion species on human cells are being investigated extensively, little is known about the effects of exposure to both radiation types. One useful measure of mammalian cell damage is induction of the ability to grow in a semi-solid agar medium highly inhibitory to the growth of normal human cells, termed neoplastic transformation. Using primary human cells, we evaluated induction of soft-agar growth and survival of cells exposed to protons only or to heavy charged particles (600 MeV/nucleon silicon) only as well as of cells exposed to protons followed after a 4-day interval by silicon ions. Both ions alone efficiently transformed the human cells to anchorage-independent growth. Initial experiments indicate that the dose responses for neoplastic transformation of cells exposed to protons and then after 4 days to silicon ions appear similar to that of cells exposed to silicon ions alone. JF - Radiation research AU - Sutherland, B M AU - Cuomo, N C AU - Bennett, P V AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 493 EP - 496 VL - 164 IS - 4 Pt 2 SN - 0033-7587, 0033-7587 KW - Protons KW - 0 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Cells, Cultured KW - Humans KW - Fibroblasts -- radiation effects KW - Dose-Response Relationship, Radiation KW - Protons -- adverse effects KW - Cell Proliferation -- radiation effects KW - Space Flight KW - Cosmic Radiation -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68634651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Induction+of+anchorage-independent+growth+in+primary+human+cells+exposed+to+protons+or+HZE+ions+separately+or+in+dual+exposures.&rft.au=Sutherland%2C+B+M%3BCuomo%2C+N+C%3BBennett%2C+P+V&rft.aulast=Sutherland&rft.aufirst=B&rft.date=2005-10-01&rft.volume=164&rft.issue=4+Pt+2&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-10 N1 - Date created - 2005-09-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Effect of A-site cation radius on ordering of BX (sub 6) octahedra in (K,Na)MgF (sub 3) perovskite AN - 51642778; 2006-007997 AB - We present a structural model for (K,Na)MgF (sub 3) perovskite using results from high-resolution synchrotron X-ray powder diffraction and nuclear magnetic resonance (NMR) spectroscopy. (K,Na)MgF (sub 3) perovskite is found to transition from orthorhombic (Pbnm) to tetragonal (P4/mbm) to cubic (Pm[Formula: see text]m) as potassium concentration is increased. These phase transitions are not accompanied by a discontinuity in pseudo-cubic unit-cell volume and occur close to compositions (K (sub 0.37) Na (sub 0.63) )MgF (sub 3) and (K (sub 0.47) Na (sub 0.53) )MgF (sub 3) , respectively. (super 19) F NMR spectra indicate that the Na (super +) and K (super +) cations do not occupy the A cation site at random and end-member local environments are favored for all compositions. Based on results from both X-ray diffraction and NMR, we propose that diffuse diffraction is the result of strain between coexisting regions of different octahedra (MgF (sub 6) ) tilts brought about by the ionic radius mismatch of Na (super +) and K (super +) cations. We suggest A-site cations group with like cations as neighbors to reduce excess volume and total strain. JF - American Mineralogist AU - Martin, C David AU - Chaudhuri, Santanu AU - Grey, Clare P AU - Parise, John B Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1522 EP - 1533 PB - Mineralogical Society of America, Washington, DC VL - 90 IS - 10 SN - 0003-004X, 0003-004X KW - synchrotron radiation KW - X-ray diffraction data KW - perovskite KW - oxides KW - cations KW - crystal structure KW - spectra KW - powder method KW - synthetic materials KW - NMR spectra KW - order-disorder KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51642778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Effect+of+A-site+cation+radius+on+ordering+of+BX+%28sub+6%29+octahedra+in+%28K%2CNa%29MgF+%28sub+3%29+perovskite&rft.au=Martin%2C+C+David%3BChaudhuri%2C+Santanu%3BGrey%2C+Clare+P%3BParise%2C+John+B&rft.aulast=Martin&rft.aufirst=Bernd&rft.date=2005-11-01&rft.volume=54&rft.issue=5&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20695 L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Abstract, copyright, Mineralogical Society of America | Reference includes data from GeoScienceWorld, Alexandria, VA, United States N1 - Date revised - 2006-01-01 N1 - Number of references - 72 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - cations; crystal structure; NMR spectra; order-disorder; oxides; perovskite; powder method; spectra; synchrotron radiation; synthetic materials; X-ray diffraction data DO - http://dx.doi.org/10.2138/am.2005.1693 ER - TY - JOUR T1 - Effects of in situ remediation on the speciation and bioavailability of zinc in a smelter contaminated soil AN - 51630916; 2006-017026 AB - We report results from an extensive study on the speciation of zinc (Zn) and its relation to the mobility and bioavailablity of this element in a smelter contaminated soil and an in situ remediated area of this soil 12 yr after the application of cyclonic ash and compost. Emphasis was placed on the role of neoformed precipitates in controlling Zn speciation, mobility and bioavailability under different environmental conditions. Twelve years after remediation, the pH of the treated and non-treated soil differed by only 0.5 pH unit. Using state-of-the-art electron and X-ray microscopies in combination with micro-focused extended X-ray absorption fine structure (mu -EXAFS) spectroscopy, no major differences in Zn speciation were found between samples of the treated and non-treated soil. In both soils, 30% to 50% of Zn was present in smelter related minerals (willemite, hemimorphite or gahnite), while 50% to 70% of Zn was incorporated into newly formed Zn precipitates. Contrary to the non-treated soil, the treated soil did not contain gahnite or sphalerite; it is possible that these minerals were dissolved under the higher pH conditions at the time of treatment. Desorption experiments, using a stirred flow technique with a 0.1 mol/L CaCl (sub 2) (pH 6.5) and a HNO (sub 3) (pH 4.0) solution were employed to determine the exchangeable Zn fraction and the Zn fraction which will be mobilized under more extreme weathering conditions, respectively. No significant differences were found in desorption behavior between the treated vs. non-treated soil. Bioavailability tests, using the R. metallidurans AE1433 biosensor showed that approximately 8% of total Zn was bioavailable in both the treated and non-treated soils. It was concluded that the incorporation of Zn into newly formed precipitates in both the treated and non treated soils leads to a significant natural attenuation of the exchangeable/bioavailable Zn fraction at near neutral pH conditions. At lower pHs, conditions not favorable to the formation of Zn precipitates, the pool of Zn associated with the secondary Zn precipitates is potentially more bioavailable. JF - Geochimica et Cosmochimica Acta AU - Nachtegaal, Maarten AU - Marcus, M A AU - Sonke, J E AU - Vangronsveld, Jaco AU - Livi, K J T AU - van der Lelie, Daniel AU - Sparks, D L Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 4649 EP - 4664 PB - Pergamon, Oxford VL - 69 IS - 19 SN - 0016-7037, 0016-7037 KW - solute transport KW - silicates KW - zinc KW - desorption KW - Ralstonia metallidurans KW - mass spectra KW - bioavailability KW - remediation KW - electron probe data KW - mineral composition KW - orthosilicates KW - X-ray fluorescence spectra KW - spectra KW - chemical composition KW - geochemistry KW - smelting KW - pH KW - soils KW - mines KW - in situ KW - pollutants KW - pollution KW - nesosilicates KW - ICP mass spectra KW - biogenic processes KW - Ralstonia KW - willemite KW - phenakite group KW - precipitation KW - metals KW - bacteria KW - EXAFS data KW - mobilization KW - microorganisms KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51630916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Effects+of+in+situ+remediation+on+the+speciation+and+bioavailability+of+zinc+in+a+smelter+contaminated+soil&rft.au=Nachtegaal%2C+Maarten%3BMarcus%2C+M+A%3BSonke%2C+J+E%3BVangronsveld%2C+Jaco%3BLivi%2C+K+J+T%3Bvan+der+Lelie%2C+Daniel%3BSparks%2C+D+L&rft.aulast=Nachtegaal&rft.aufirst=Maarten&rft.date=2005-10-01&rft.volume=69&rft.issue=19&rft.spage=4649&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2Fj.gca.2005.05.019 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2006-01-01 N1 - Number of references - 72 N1 - Document feature - illus. incl. 3 tables, 2 plates N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - bacteria; bioavailability; biogenic processes; chemical composition; chemical fractionation; desorption; electron probe data; EXAFS data; geochemistry; ICP mass spectra; in situ; mass spectra; metals; microorganisms; mineral composition; mines; mobilization; nesosilicates; orthosilicates; pH; phenakite group; pollutants; pollution; precipitation; Ralstonia; Ralstonia metallidurans; remediation; silicates; smelting; soils; solute transport; spectra; willemite; X-ray fluorescence spectra; zinc DO - http://dx.doi.org/10.1016/j.gca.2005.05.019 ER - TY - JOUR T1 - Fabric and uranyl retention of neomorphosed aragonite botryoids; constraints on the diagenetic process AN - 51558596; 2006-062146 AB - Folk pioneered the recognition of aragonite precursors, speculation on elemental interactions with carbonates, and utilization of his white-card technique to reveal relict fabric and distribution of organics. We propose that the degree of fabric retention and trace-element behavior can be used to gain insight into processes of neomorphism of aragonite to calcite. Our examples are relict botryoidal aragonite cement fabrics preserved in mosaic calcites of the Upper Carboniferous Laborcita algal mounds (Sacramento Mts, N.M.). Their brown color and pleochroism have been attributed to ubiquitous fine-scale organic inclusions. The white-card technique reveals that the better the fabric preservation, the more uniform and brown the color. The fibrous fabric is mainly preserved by solid opaque organic and other non-carbonate inclusions. Inclusions of relict aragonite are oriented with growth direction. The calcite with the relict aragonite fabric has 4.1-4.6 ppm U and 1000-2000 ppm Sr. Preliminary synchrotron X-ray analyses of the intermediate energy U-M5 edge shows U is mainly in the oxidized state (uranyl ion). Modern marine aragonite cements have approximately 4 ppm U and 8,000-10,000 ppm Sr. If the Carboniferous aragonite had concentrations similar to the modern, then U was largely retained while Sr was decreased up to 90%. Paradoxically, based on distribution coefficients (Kd's), more U than Sr should have been lost during the replacement of aragonite by calcite (Kd for Sr+2 in calcite is 0.05 to 0.14; Kd for U+6 is 0.002-0.05). We propose that in the reaction zone during replacement U was either physically trapped or sequestered by another phase. It is unlikely that the uranyl ion alone was trapped because it is similar in size to CO3. However, if a uranyl-organic-matter complex was originally incorporated into the aragonite, then such a molecule may have been larger than the "sieve size" of the reaction zone. This scenario predicts homogeneous distribution of U. Alternatively, the uranyl ion may have been sequestered by the organics or oxides defining the relict fabric. This predicts a heterogeneous distribution with U concentrated in opaque inclusions. Both scenarios are consistent with U retention coupled with fabric preservation. JF - Abstracts with Programs - Geological Society of America AU - Rasbury, E Troy AU - Ward, W Bruce AU - Northrup, Paul A AU - Anonymous Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 254 PB - Geological Society of America (GSA), Boulder, CO VL - 37 IS - 7 SN - 0016-7592, 0016-7592 KW - United States KW - processes KW - Sacramento Mountains KW - aragonite KW - Paleozoic KW - Carboniferous KW - uranyl ion KW - crystal growth KW - New Mexico KW - Upper Carboniferous KW - calcite KW - pleochroism KW - partition coefficients KW - X-ray data KW - metals KW - diagenesis KW - uranium KW - trace elements KW - fabric KW - carbonates KW - actinides KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51558596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Fabric+and+uranyl+retention+of+neomorphosed+aragonite+botryoids%3B+constraints+on+the+diagenetic+process&rft.au=Rasbury%2C+E+Troy%3BWard%2C+W+Bruce%3BNorthrup%2C+Paul+A%3BAnonymous&rft.aulast=Rasbury&rft.aufirst=E&rft.date=2005-10-01&rft.volume=37&rft.issue=7&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2005 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2006-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - actinides; aragonite; calcite; carbonates; Carboniferous; crystal growth; diagenesis; fabric; metals; New Mexico; Paleozoic; partition coefficients; pleochroism; processes; Sacramento Mountains; trace elements; United States; Upper Carboniferous; uranium; uranyl ion; X-ray data ER - TY - JOUR T1 - Kinetics study on separation of cadmium from tellurium in acidic solution media using ion-exchange resins AN - 19672333; 6691643 AB - The feasibility of using ion-exchange resins to separate cadmium from tellurium in acidic solutions of the two metals was investigated. We studied the competitive adsorption of cadmium and tellurium in such resins under varying acid strengths and contact time. We found that low sulfuric acid strength (i.e., 0.5 M) was most effective in removing cadmium from solutions. Different ion- exchange resins were tested for their affinity for cadmium and tellurium ions. In the selected systems, the ion-exchange rate of cadmium was rapid in the first 20 min, and reached equilibrium within 2 h. The Lagergren first-order model described the kinetic data with high coefficient of determination and correlation values. At room temperatures the ion-exchange for cadmium onto the resin followed the Freundlich isotherm model. The maximum removal of cadmium obtained from batch studies using resin A was 91%. Column studies with the same resin showed a removal of cadmium of 99.99% or higher. JF - Journal of Hazardous Materials AU - Wang, Wenming AU - Fthenakis, Vasilis AD - National Photovoltaic Environmental Health and Safety Research Center, Brookhaven National Laboratory, Upton, NY 11973, USA, vmf@bnl.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 80 EP - 88 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 125 IS - 1-3 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts KW - Cadmium KW - Tellurium KW - Waste management KW - Ion-exchange KW - Recycling KW - Photovoltaics KW - Feasibility studies KW - Heavy metals KW - tellurium KW - Models KW - Sulfuric acid KW - Isotherms KW - Ion exchange KW - Temperature effects KW - Metals KW - Ions KW - Resins KW - Data processing KW - Temperature KW - affinity KW - Kinetics KW - Adsorption KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19672333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Kinetics+study+on+separation+of+cadmium+from+tellurium+in+acidic+solution+media+using+ion-exchange+resins&rft.au=Wang%2C+Wenming%3BFthenakis%2C+Vasilis&rft.aulast=Wang&rft.aufirst=Wenming&rft.date=2005-10-01&rft.volume=125&rft.issue=1-3&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2005.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Temperature effects; Ions; Resins; Data processing; Heavy metals; Kinetics; tellurium; Adsorption; Sulfuric acid; Cadmium; Isotherms; Models; Feasibility studies; Metals; Tellurium; Temperature; Ion exchange; affinity DO - http://dx.doi.org/10.1016/j.jhazmat.2005.02.013 ER - TY - JOUR T1 - Cytotoxic Effects of Low- and High-LET Radiation on Human Neuronal Progenitor Cells: Induction of Apoptosis and TP53 Gene Expression AN - 17384149; 6485791 AB - The induction of apoptosis, TP53 expression, caspase activation and cell toxicity were investigated after exposure of cells of the human neuronal progenitor cell line Ntera2 (NT2) to low-LET radiation ( gamma and X rays). The data indicates that irradiation of NT2 cells quickly induced TP53 expression, which was followed in time by an increase in caspase activity, and ultimately resulted in the induction of apoptosis. Induction of apoptosis was dependent on dose, and the highest levels were measured 48 h after exposure. For comparison, the level of apoptosis induced by high-LET particle radiation (1 GeV/nucleon iron ions) was also determined and was found to be dependent on dose. The relative biological effectiveness (RBE) was estimated from the slopes of the dose-response curves for the induction of apoptosis. The RBE sub(max) for apoptosis 48 h after exposure was at least 3.4. In short, exposure to high-LET radiation results in a more efficient and greater induction of apoptosis in human neuronal progenitor cells than low-LET radiation. JF - Radiation Research AU - Guida, P AU - Vazquez, ME AU - Otto, S AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973 Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 545 EP - 551 PB - Radiation Research Society VL - 164 IS - 4 SN - 0033-7587, 0033-7587 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Ions KW - X radiation KW - alpha Radiation KW - Apoptosis KW - Data processing KW - Toxicity KW - p53 protein KW - Cell activation KW - Gene expression KW - Stem cells KW - Cytotoxicity KW - Radiation KW - gamma Radiation KW - Neurotrophin 2 KW - Caspase KW - Iron KW - Neural stem cells KW - X 24210:Radiation & radioactive materials KW - N3 11101:General KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17384149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Cytotoxic+Effects+of+Low-+and+High-LET+Radiation+on+Human+Neuronal+Progenitor+Cells%3A+Induction+of+Apoptosis+and+TP53+Gene+Expression&rft.au=Guida%2C+P%3BVazquez%2C+ME%3BOtto%2C+S&rft.aulast=Guida&rft.aufirst=P&rft.date=2005-10-01&rft.volume=164&rft.issue=4&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1043%2F0033-7587%282005%291642.0.CO%3B2 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=164&issue=4&page=545 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Ions; alpha Radiation; X radiation; Data processing; Apoptosis; Toxicity; Cell activation; p53 protein; Gene expression; Cytotoxicity; Stem cells; Radiation; Neurotrophin 2; gamma Radiation; Caspase; Neural stem cells; Iron DO - http://dx.doi.org/10.1043/0033-7587(2005)164[0545:CEOLAH]2.0.CO;2 ER - TY - JOUR T1 - Endogenous DNA damage clusters in human skin, 3-D model, and cultured skin cells. AN - 68497076; 16109312 AB - Clustered damages-two or more oxidized bases, abasic sites, or strand breaks on opposing DNA strands within a few helical turns-are formed in DNA by ionizing radiation. Clusters are difficult for cells to repair and thus pose significant challenges to genomic integrity. Although endogenous clusters were found in some permanent human cell lines, it was not known if clusters accumulated in human tissues or primary cells. Using high-sensitivity gel electrophoresis, electronic imaging, and number average length analysis, we determined endogenous cluster levels in DNA from human skin, a 3-D skin model, and primary cultured skin cells. DNA from dermis and epidermis of human skin contained extremely low levels of endogenous clusters (a few per gigabase). However, cultured skin fibroblasts and keratinocytes-whether in monolayer cultures or in 3-D model skin cultures-accumulated oxidized pyrimidine, oxidized purine, and abasic clusters. The levels of endogenous clusters were decreased by growing cells in the presence of selenium or by increasing cellular levels of Fpg protein, presumably by increasing processing of clustered damages. These results imply that the levels of endogenous clusters can be affected by the cells' external environment and their ability to deal with DNA damage. JF - Free radical biology & medicine AU - Bennett, Paula V AU - Cuomo, Noelle L AU - Paul, Sunirmal AU - Tafrov, Stefan T AU - Sutherland, Betsy M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 SP - 832 EP - 839 VL - 39 IS - 6 SN - 0891-5849, 0891-5849 KW - Purines KW - 0 KW - Pyrimidines KW - DNA KW - 9007-49-2 KW - pyrimidine KW - K8CXK5Q32L KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - DNA Repair KW - Dermis -- cytology KW - Oxygen -- metabolism KW - Epidermis -- cytology KW - Humans KW - Pyrimidines -- pharmacology KW - Dose-Response Relationship, Radiation KW - Fibroblasts -- metabolism KW - Cells, Cultured KW - Electrophoresis, Agar Gel KW - Purines -- pharmacology KW - CHO Cells KW - Keratinocytes -- cytology KW - Purines -- chemistry KW - Radiation, Ionizing KW - Cricetinae KW - Skin -- radiation effects KW - DNA Damage KW - Skin -- metabolism KW - DNA -- metabolism KW - Skin -- pathology KW - Skin -- cytology KW - DNA -- chemistry KW - DNA -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68497076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Analysis+of+Morris+Water+Maze+Data+from+HVS+Running+Systems+Using+Microsoft+Excel+and+Sigma+Stat&rft.au=Flavin%2C+N+J%3BNeill%2C+J+C&rft.aulast=Flavin&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-20 N1 - Date created - 2005-08-19 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Mutat Res. 2002 Nov 30;509(1-2):23-34 [12427529] Oncogene. 2002 Dec 16;21(58):8926-34 [12483509] Free Radic Biol Med. 2002 Jun 1;32(11):1102-15 [12031895] Radiat Res. 2002 Jun;157(6):611-6 [12005538] Acta Biochim Pol. 2000;47(4):1197-8 [11996110] J Inherit Metab Dis. 2002 May;25(3):215-22 [12137230] Nucleic Acids Res. 2002 Jul 1;30(13):2800-8 [12087163] Biol Chem. 2002 Mar-Apr;383(3-4):467-75 [12033436] J Biol Chem. 2003 Mar 14;278(11):9005-12 [12519758] Biochemistry. 2003 Mar 25;42(11):3375-84 [12641470] Free Radic Biol Med. 2003 Sep 1;35(5):495-503 [12927599] Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12871-6 [14566050] Free Radic Biol Med. 2004 Jan 15;36(2):259-66 [14744637] Nucleic Acids Res. 2004;32(4):1602-9 [15004247] Free Radic Biol Med. 2004 Aug 15;37(4):488-99 [15256220] DNA Repair (Amst). 2004 Oct 5;3(10):1323-34 [15336627] Semin Cancer Biol. 2004 Dec;14(6):441-8 [15489137] Nucleic Acids Res. 2004;32(18):5609-20 [15494449] Photochem Photobiol. 1975 May;21(5):373-5 [1208665] Somat Cell Mol Genet. 1986 Mar;12(2):185-95 [3008351] Anal Biochem. 1986 Oct;158(1):119-29 [3799960] Anal Biochem. 1987 Jun;163(2):446-57 [3661993] Radiat Res. 1993 Jun;134(3):307-15 [8316623] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22 [8367443] Int J Radiat Biol. 1994 Jan;65(1):7-17 [7905912] Int J Radiat Biol. 1994 Nov;66(5):427-32 [7983426] Nucleic Acids Res. 1994 Nov 25;22(23):4943-6 [7800484] J Mol Biol. 1995 Jun 23;249(5):914-22 [7791217] Cancer Res. 1997 Feb 1;57(3):420-5 [9012468] J Biol Chem. 1997 Jun 20;272(25):15650-5 [9188454] Carcinogenesis. 1997 Nov;18(11):2225-31 [9395225] Nucleic Acids Res. 1998 Feb 15;26(4):932-41 [9461450] Radiat Res. 1998 Nov;150(5 Suppl):S60-79 [9806610] EMBO J. 2004 Nov 10;23(22):4484-94 [15496986] J Mol Biol. 2005 Jan 28;345(4):731-43 [15588822] Tissue Eng. 2004 Sep-Oct;10(9-10):1332-45 [15588394] FASEB J. 2005 Jan;19(1):82-4 [15533950] Nucleic Acids Res. 2005;33(1):260-71 [15647508] Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5 [10557315] J Biol Chem. 2000 Apr 21;275(16):11865-73 [10766813] Biochemistry. 2000 Jul 11;39(27):8026-31 [10891084] Curr Opin Cell Biol. 2001 Apr;13(2):225-31 [11248557] Mutat Res. 2001 Apr 18;475(1-2):7-20 [11295149] Electrophoresis. 2001 Mar;22(5):843-54 [11332751] Free Radic Biol Med. 2001 Jun 15;30(12):1418-25 [11390187] N1 - Last updated - 2017-02-22 ER - TY - CPAPER T1 - Biotransformation of Uranium Complexed with Organic Ligands T2 - 4th International Conference on Uranium Mining and Hydrogeology (UMH IV) AN - 39649096; 3980286 JF - 4th International Conference on Uranium Mining and Hydrogeology (UMH IV) AU - Francis, A J Y1 - 2005/09/11/ PY - 2005 DA - 2005 Sep 11 KW - Uranium KW - Biotransformation KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39649096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Aging+and+Seizures+on+Auditory+Discrimination&rft.au=Neill%2C+J+C%3BHolmes%2C+G+L&rft.aulast=Neill&rft.aufirst=J&rft.date=2005-11-12&rft.volume=27&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Criminal+Justice+Education&rft.issn=10511253&rft_id=info:doi/10.1080%2F10511253.2015.1078387 L2 - http://www.geo.tu-freiberg.de/umh/Accepted%20Papers.htm#Topic1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Data Supporting an Important Role for Wavelengths Greater than UVB in Inducing Melanomas T2 - 6th World Congress on Melanoma AN - 40029906; 3994387 JF - 6th World Congress on Melanoma AU - Setlow, R Y1 - 2005/09/06/ PY - 2005 DA - 2005 Sep 06 KW - Melanoma KW - Wavelength KW - U.V. radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40029906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Melanoma&rft.atitle=Data+Supporting+an+Important+Role+for+Wavelengths+Greater+than+UVB+in+Inducing+Melanomas&rft.au=Setlow%2C+R&rft.aulast=Setlow&rft.aufirst=R&rft.date=2005-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Melanoma&rft.issn=&rft_id=info:doi/ L2 - http://www.venuewest.com/worldmelanoma/images/6th_Melanoma_Web_Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structural Analysis of Botulinum Neurotoxin Serotype F Light Chain: Implications on Substrate Binding and Inhibitor Design AN - 19847615; 6757725 AB - The seven serologically distinct Clostridium botulinum neurotoxins (BoNTs A-G) are zinc endopeptidases which block the neurotransmitter release by cleaving one of the three proteins of the soluble N-ethylmaleimide-sensitive-factor attachment protein receptor complex (SNARE complex) essential for the fusion of vesicles containing neurotransmitters with target membranes. These metallopeptidases exhibit unique specificity for the substrates and peptide bonds they cleave. Development of countermeasures and therapeutics for BoNTs is a priority because of their extreme toxicity and potential misuse as biowarfare agents. Though they share sequence homology and structural similarity, the structural information on each one of them is required to understand the mechanism of action of all of them because of their specificity. Unraveling the mechanism will help in the ultimate goal of developing inhibitors as antibotulinum drugs for the toxins. Here, we report the high-resolution structure of active BoNT/F catalytic domain in two crystal forms. The structure was exploited for modeling the substrate binding and identifying the S1' subsite and the putative exosites which are different from BoNT/A or BoNT/B. The orientation of docking of the substrate at the active site is consistent with the experimental BoNT/A-LC:SNAP-25 peptide model and our proposed model for BoNT/E-LC:SNAP-25. JF - Biochemistry (Washington) AU - Agarwal, R AU - Binz, T AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA Y1 - 2005/09/06/ PY - 2005 DA - 2005 Sep 06 SP - 11758 EP - 11765 VL - 44 IS - 35 SN - 0006-2960, 0006-2960 KW - botulinum toxin type F KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts KW - Light chains KW - Serotypes KW - zinc endopeptidase KW - Clostridium botulinum KW - Crystals KW - Toxicity KW - SNAP receptors KW - Toxins KW - Metalloproteinase KW - Homology KW - SNAP-25 protein KW - Crystal structure KW - Neurotransmitters KW - Botulinum toxin KW - Neurotoxins KW - Drugs KW - Neurotransmitter release KW - Vesicle fusion KW - J 02822:Biosynthesis and physicochemical properties KW - X 24360:Metals KW - N3 11070:Neurochemistry and cellular biology KW - A 01023:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19847615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Optical+Brain+Monitoring+of+Cerebrovascular+and+Intracellular+Calcium+Effects+Induced+by+Acute+Cocaine+Exposure+in+the+Living+Rat&rft.au=Du%2C+C.%3BThanos%2C+P+K%3BYu%2C+M.%3BRivera%2C+S%3BBenveniste%2C+H&rft.aulast=Du&rft.aufirst=C.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Light chains; Serotypes; zinc endopeptidase; Toxicity; Crystals; Toxins; SNAP receptors; Metalloproteinase; Homology; SNAP-25 protein; Crystal structure; Botulinum toxin; Neurotransmitters; Neurotoxins; Drugs; Neurotransmitter release; Vesicle fusion; Clostridium botulinum DO - http://dx.doi.org/10.1021/bi0510072 ER - TY - JOUR T1 - My early days in photobiology with Philip Hanawalt AN - 19821164; 6513056 AB - Phil and I started our careers on somewhat similar scientific paths. I had an undergraduate degree in physics from Swarthmore College and a Ph.D. degree in physics from Yale for research in the field for ultraviolet spectroscopy. Phil received an undergraduate degree in Physics from Oberlin College, joined the Yale Physics Department in 1954, and transferred to the new Biophysics Department in 1955. We began our interactions then by virtue of the fact that Phil had to take a Laboratory Course in Experimental Physics, one part of which was spectroscopy in which I was the instructor. One of my principal interests was in the effects of different wavelengths of ultraviolet (UV) radiation on proteins, viruses and bacterial cells. So what was more natural than for Phil to dream up a Ph.D. research project to investigate the effects of different wavelengths of UV on macromolecular synthesis in Escherichia coli. I became his mentor with expertise in UV, whereas he did most of the microbiological/biochemical work. Thus began a collaboration and a communicating friendship, the latter going on for 50 years. That communication was essential in elucidating some of the important steps in nucleotide excision repair-a field in which Phil is a pre-eminent scholar and investigator. JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Setlow, R B AD - Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA, setlow@bnl.gov Y1 - 2005/09/04/ PY - 2005 DA - 2005 Sep 04 SP - 4 EP - 8 VL - 577 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Molecular modelling KW - Dreams KW - Macromolecules KW - U.V. radiation KW - Escherichia coli KW - Communication KW - Wavelength KW - Spectroscopy KW - Nucleotides KW - Biophysics KW - Mutagenesis KW - N 14025:RNA/DNA role in infection & immune response KW - J 02320:Cell Biology KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19821164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Long+-+term+Effects+of+Whole+-+brain+Irradiation+on+Auditory+Discrimination&rft.au=Aubele%2C+T+M%3BKristiansen%2C+R%3BMurphy%2C+M%3BRice%2C+O%3BGately%2C+S+J&rft.aulast=Aubele&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Macromolecules; Dreams; U.V. radiation; Communication; Wavelength; Spectroscopy; Nucleotides; Mutagenesis; Biophysics; Escherichia coli DO - http://dx.doi.org/10.1016/j.mrfmmm.2005.01.031 ER - TY - JOUR T1 - Hierarchical approach to model multilayer colloidal deposition in porous media. AN - 68633299; 16190188 AB - Particle deposition is important in many environmental systems such as water and wastewater filtration, air pollution control, subsurface transport, biofilm formation and fouling, and thin film synthesis for use in remediation technologies. While continuum-level models have been developed to predict deposition dynamics in these systems, these models fail to explain transient dynamics of multilayer deposition from a mechanistic viewpoint. In this work, a multiscale approach has been developed to predict multiple layer irreversible colloidal deposition in the presence of interparticle electrostatic and van der Waals interactions in porous media. The approach combines the kinetic information obtained from the mesoscopic stochastic simulations of particle deposition with the macroscopic conservation equation describing colloidal transport. Sequential Brownian dynamics simulations are first performed by accounting for particle-particle (P-P) and particle-surface (P-S) interactions, and multilayered particle deposits are obtained. The available surface function quantifying the deposition kinetics is then obtained from the deposit microstructure. Deposition dynamics are studied at different ionic strengths and particle potentials that control the range and magnitude of interparticle interactions. Simulation results showed that the microstructure of the particle deposits formed under the influence of P-P and P-S electrostatic interactions exhibited significant variations with respect to ionic strength and could be qualitatively explained bythe interplay between the repulsive and attractive P-P and P-S interaction forces. The available surface function also varied significantly as a function of ionic strength. This basic understanding of the deposition dynamics at the mesoscale was then combined with the continuum-level transport equations to predict particle breakthrough curves in porous media. The approach is capable of capturing transient features of deposition dynamics, as demonstrated by the good agreement between the model predictions and the experimental observations. JF - Environmental science & technology AU - Kulkarni, Pramod AU - Sureshkumar, R AU - Biswas, Pratim AD - Brookhaven National Laboratory, P.O. Box 5000, Building 815E, Upton, New York 11973, USA. Y1 - 2005/09/01/ PY - 2005 DA - 2005 Sep 01 SP - 6361 EP - 6370 VL - 39 IS - 17 SN - 0013-936X, 0013-936X KW - Colloids KW - 0 KW - Water Pollutants KW - Index Medicus KW - Static Electricity KW - Osmolar Concentration KW - Kinetics KW - Porosity KW - Adsorption KW - Surface Properties KW - Nanostructures KW - Models, Theoretical KW - Water Pollutants -- analysis KW - Colloids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68633299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harvard+Law+Review&rft.atitle=Systemic+Facts%3A+Toward+Institutional+Awareness+in+Criminal+Courts&rft.au=Crespo%2C+Andrew+Manuel&rft.aulast=Crespo&rft.aufirst=Andrew&rft.date=2016-06-01&rft.volume=129&rft.issue=8&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Harvard+Law+Review&rft.issn=0017811X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-09-29 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - A Multifunctional Acyl-Acyl Carrier Protein Desaturase from Hedera helix L. (English Ivy) Can Synthesize 16- and 18-Carbon Monoene and Diene Products AN - 19766414; 6414838 AB - A desaturase with 83% sequence identity to the coriander Delta super(4)-16:0-ACP desaturase was isolated from developing seeds of Hedera helix (English ivy). Expression of the ivy desaturase in Arabidopsis resulted in the accumulation of 16:1 Delta super(4) and its expected elongation product 18:1 Delta super(6) (petroselinic acid). Expression in Escherichia coli resulted in the accumulation of soluble, active protein that was purified to apparent homogeneity. In vitro assays confirmed Delta super(4) desaturation with 16:0-ACP; however, with 18:0-acyl acyl carrier protein (ACP) desaturation occurred at the Delta super(9) position. The ivy desaturase also converted 16:1 Delta super(9)-ACP and 18:1 Delta super(9)-ACP to the corresponding Delta super(4,9) dienes. These data suggest at least two distinct substrate binding modes, one placing C4 at the diiron active site and the other placing C9 at the active site. In the latter case, 18:0 would likely bind in an extended conformation as described for the castor desaturase with 9-carbons accommodated in the cavity beyond the dirron site. However, Delta super(4) desaturation would require the accommodation of 12 carbons for C16 substrates or 14 carbons for C18 substrates. The amino acids lining the substrate binding cavity of ivy and castor desaturases are conserved except for T117R and P179I (castor/ivy). Paradoxically, both substitutions, when introduced into the castor desaturase, favored the binding of shorter acyl chains. Thus, it seems likely that Delta super(4) desaturation would require a non-extended, perhaps U-shaped, substrate conformation. A cis double bond may facilitate the initiation of such a non-extended conformation in the monounsaturated substrates. The multifunctional properties of the ivy desaturase make it well suited for further dissection of the determinants of regiospecificity. JF - Journal of Biological Chemistry AU - Whittle, Edward AU - Cahoon, Edgar B AU - Subrahmanyam, Satyam AU - Shanklin, John AD - Biology Department, Brookhaven National Laboratory, Upton, New York, 11973 and United States Department of Agriculture-Agricultural Research Service Plant Genetics Research Unit, Donald Danforth Plant Science Center, St. Louis, Missouri 63132 Y1 - 2005/08/05/ PY - 2005 DA - 2005 Aug 05 SP - 28169 EP - 28176 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 31 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Cavities KW - Seeds KW - Data processing KW - Amino acids KW - Hedera helix KW - Elongation KW - Carbon KW - Escherichia coli KW - Castor KW - Arabidopsis KW - desaturase KW - Acyl carrier protein KW - J 02420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19766414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=A+Multifunctional+Acyl-Acyl+Carrier+Protein+Desaturase+from+Hedera+helix+L.+%28English+Ivy%29+Can+Synthesize+16-+and+18-Carbon+Monoene+and+Diene+Products&rft.au=Whittle%2C+Edward%3BCahoon%2C+Edgar+B%3BSubrahmanyam%2C+Satyam%3BShanklin%2C+John&rft.aulast=Whittle&rft.aufirst=Edward&rft.date=2005-08-05&rft.volume=280&rft.issue=31&rft.spage=28169&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Elongation; Cavities; Seeds; Amino acids; Data processing; Carbon; desaturase; Acyl carrier protein; Hedera helix; Escherichia coli; Castor; Arabidopsis ER - TY - JOUR T1 - Interactions of uranium with bacteria and kaolinite clay AN - 51678255; 2005-062511 AB - We assessed the accumulation of uranium (VI) by a bacterium, Bacillus subtilis, suspended in a slurry of kaolinite clay, to elucidate the role of microbes on the mobility of U(VI). Various mixtures of bacteria and the kaolinite were exposed to solutions of 8X10 (super -6) M- and 4X10 (super -4) M-U(VI) in 0.01 M NaCl at pH 4.7. After 48 h, the mixtures were separated from the solutions by centrifugation, and treated with a 1 M CH (sub 3) COOK for 24 h to determine the associations of U within the mixture. The mixture exposed to 4X10 (super -4) M U was analyzed by transmission electron microscope (TEM) equipped with EDS. The accumulation of U by the mixture increased with an increase in the amount of B. subtilis cells present at both U concentrations. Treatment of kaolinite with CH (sub 3) COOK, removed approximately 80% of the associated uranium. However, in the presence of B. subtilis the amount of U removed was much less. TEM-EDS analysis confirmed that most of the U removed from solution was associated with B. subtilis. XANES analysis of the oxidation state of uranium associated with B. subtilis, kaolinite, and with the mixture containing both revealed that it was present as U(VI). These results suggest that the bacteria have a higher affinity for U than the kaolinite clay mineral under the experimental conditions tested, and that they can immobilize significant amount of uranium. JF - Chemical Geology AU - Ohnuki, Toshihiko AU - Yoshida, T AU - Ozaki, T AU - Samadfam, M AU - Kozai, N AU - Yubuta, K AU - Mitsugashira, T AU - Kasama, T AU - Francis, A J Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 237 EP - 243 PB - Elsevier, Amsterdam VL - 220 IS - 3-4 SN - 0009-2541, 0009-2541 KW - silicates KW - kaolinite KW - solution KW - X-ray spectra KW - TEM data KW - energy dispersive X-ray spectra KW - clay minerals KW - XANES spectra KW - biogenic processes KW - water-rock interaction KW - metals KW - bacteria KW - sheet silicates KW - uranium KW - spectra KW - mobilization KW - chemical composition KW - geochemistry KW - Bacillus KW - actinides KW - microorganisms KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51678255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Geology&rft.atitle=Interactions+of+uranium+with+bacteria+and+kaolinite+clay&rft.au=Biegon%2C+A%3BPareto%2C+D%3BGuol%2C+J%3BKofke%2C+W&rft.aulast=Biegon&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00092541 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 26 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - CHGEAD N1 - SubjectsTermNotLitGenreText - actinides; Bacillus; bacteria; biogenic processes; chemical composition; clay minerals; energy dispersive X-ray spectra; geochemistry; kaolinite; metals; microorganisms; mobilization; sheet silicates; silicates; solution; spectra; TEM data; uranium; water-rock interaction; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.1016/j.chemgeo.2005.03.008 ER - TY - JOUR T1 - Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine. AN - 68011882; 15998285 AB - We have synthesized and evaluated several new ligands for imaging the norepinephrine transporter (NET) system in baboons with positron emission tomography (PET). Ligands possessing high brain penetration, high affinity and selectivity, appropriate lipophilicity (log P = 1.0-3.5), high plasma free fraction and reasonable stability in plasma were selected for further studies. Based on our characterization studies in baboons, including 11C-labeled (R)-nisoxetine (Nis), oxaprotiline (Oxap), lortalamine (Lort) and new analogs of methylreboxetine (MRB), in conjunction with our earlier evaluation of 11C and 18F derivatives of reboxetine, MRB and their individual (R,R) and (S,S) enantiomers, we have identified the superiority of (S,S)-[11C]MRB and the suitability of MRB analogs [(S,S)-[11C]MRB > (S,S)-[11C]3-Cl-MRB > (S,S)-[18F]fluororeboxetine] as potential NET ligands for PET. In contrast, Nis, Oxap and Lort displayed high uptake in striatum (higher than in thalamus). The use of these ligands is further limited by high non-specific binding and relatively low specific signal, as is characteristic of many earlier NET ligands. Thus, to our knowledge (S,S)-[11C]MRB remains by far the most promising NET ligand for PET studies. JF - Journal of neurochemistry AU - Ding, Yu-Shin AU - Lin, Kuo-Shyan AU - Logan, Jean AU - Benveniste, Helene AU - Carter, Pauline AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA. ding@bnl.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 337 EP - 351 VL - 94 IS - 2 SN - 0022-3042, 0022-3042 KW - Adrenergic Uptake Inhibitors KW - 0 KW - Benzopyrans KW - Carbon Radioisotopes KW - Fluorine Radioisotopes KW - Morpholines KW - Norepinephrine Plasma Membrane Transport Proteins KW - Slc6a2 protein, mouse KW - Symporters KW - Fluoxetine KW - 01K63SUP8D KW - nisoxetine KW - 17NV064B2D KW - Maprotiline KW - 2U1W68TROF KW - hydroxymaprotilin KW - 3V3Z2HK4LS KW - reboxetine KW - 947S0YZ36I KW - lortalamine KW - 9GIR4SV22T KW - Nordefrin KW - R81X549E70 KW - Index Medicus KW - Papio KW - Animals KW - Drug Interactions KW - Fluorine Radioisotopes -- pharmacokinetics KW - Dose-Response Relationship, Drug KW - Brain Chemistry KW - Adrenergic Uptake Inhibitors -- pharmacokinetics KW - Binding, Competitive -- drug effects KW - Mice KW - Tissue Distribution KW - Adrenergic Uptake Inhibitors -- blood KW - Image Processing, Computer-Assisted -- methods KW - Carbon Radioisotopes -- pharmacokinetics KW - Evaluation Studies as Topic KW - Brain Mapping KW - Magnetic Resonance Imaging -- methods KW - Protein Binding -- drug effects KW - Nordefrin -- antagonists & inhibitors KW - Chromatography, High Pressure Liquid -- methods KW - Autoradiography -- methods KW - Time Factors KW - Radioligand Assay -- methods KW - Maprotiline -- analogs & derivatives KW - Morpholines -- pharmacokinetics KW - Fluoxetine -- analogs & derivatives KW - Maprotiline -- pharmacokinetics KW - Positron-Emission Tomography KW - Symporters -- metabolism KW - Fluoxetine -- blood KW - Brain -- metabolism KW - Brain -- diagnostic imaging KW - Morpholines -- blood KW - Fluoxetine -- pharmacokinetics KW - Benzopyrans -- pharmacokinetics KW - Benzopyrans -- blood KW - Maprotiline -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68011882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Comparative+evaluation+of+positron+emission+tomography+radiotracers+for+imaging+the+norepinephrine+transporter%3A+%28S%2CS%29+and+%28R%2CR%29+enantiomers+of+reboxetine+analogs+%28%5B11C%5Dmethylreboxetine%2C+3-Cl-%5B11C%5Dmethylreboxetine+and+%5B18F%5Dfluororeboxetine%29%2C+%28R%29-%5B11C%5Dnisoxetine%2C+%5B11C%5Doxaprotiline+and+%5B11C%5Dlortalamine.&rft.au=Ding%2C+Yu-Shin%3BLin%2C+Kuo-Shyan%3BLogan%2C+Jean%3BBenveniste%2C+Helene%3BCarter%2C+Pauline&rft.aulast=Ding&rft.aufirst=Yu-Shin&rft.date=2005-07-01&rft.volume=94&rft.issue=2&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-07 N1 - Date created - 2005-07-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Decontamination of Uranium-Contaminated Steel Surfaces by Hydroxycarboxylic Acid with Uranium Recovery AN - 19812140; 6433740 AB - We developed a simple, safe method to remove uranium from contaminated metallic surfaces so that the materials can be recycled or disposed of as low-level radioactive or nonradioactive waste. Surface analysis of rusted uranium-contaminated plain carbon-steel coupons by X-ray photoelectron spectroscopy and Rutherford backscattering spectroscopy showed that uranium was predominantly associated with ferrihydrite, lepidocrocite, and magnetite, or occluded in the matrix of the corrosion product as uranyl hydroxide and schoepite (UO sub(3) times 2H sub(2)O). Citric acid formulations, consisting of oxalic acid-hydrogen peroxide-citric acid (OPC) or citric acid-hydrogen peroxide-citric acid (CPC), were used to remove uranium from the coupons. The efficiency of uranium removal varied from 68% to 94% depending on the extent of corrosion, the association of uranium with the iron oxide matrix, and the accessibility of the occluded contaminant. Decontaminated coupons clearly showed evidence of the extensive removal of rust and uranium. The waste solutions containing uranium and iron from decontamination by OPC and CPC were treated first by subjecting them to biodegradation followed by photodegradation. Biodegradation of a CPC solution by Pseudomonas fluorescens resulted in the degradation of the citric acid with concomitant precipitation of Fe (>96%), whereas U that remained in solution was recovered (>99%) by photodegradation as schoepite. In contrast, in an OPC solution citric acid was biodegraded but not oxalic acid, and both Fe and U remained in solution. Photodegradation of this OPC solution resulted in the precipitation of iron as ferrihydrite and uranium as uranyl hydroxide. JF - Environmental Science & Technology AU - Francis, A J AU - Dodge, C J AU - McDonald, JA AU - Halada, G P AD - Environmental Sciences Department, Brookhaven National Laboratory, Upton, NY 11973, USA, francis1@bnl.gov Y1 - 2005/07/01/ PY - 2005 DA - 2005 Jul 01 SP - 5015 EP - 5021 VL - 39 IS - 13 SN - 0013-936X, 0013-936X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Biodegradation KW - iron oxides KW - Wastes KW - Decontamination KW - Precipitation KW - Spectroscopy KW - Rust KW - Pseudomonas fluorescens KW - Photodegradation KW - Uranium KW - Ionizing radiation KW - Corrosion KW - Steel KW - Contaminants KW - Photoelectron spectroscopy KW - Iron KW - Oxalic acid KW - magnetite KW - Citric acid KW - A 01056:Mineral microbiology KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19812140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Decontamination+of+Uranium-Contaminated+Steel+Surfaces+by+Hydroxycarboxylic+Acid+with+Uranium+Recovery&rft.au=Francis%2C+A+J%3BDodge%2C+C+J%3BMcDonald%2C+JA%3BHalada%2C+G+P&rft.aulast=Francis&rft.aufirst=A&rft.date=2005-07-01&rft.volume=39&rft.issue=13&rft.spage=5015&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/10.1021%2Fes048887c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Biodegradation; iron oxides; Wastes; Decontamination; Precipitation; Spectroscopy; Rust; Photodegradation; Ionizing radiation; Uranium; Corrosion; Steel; Contaminants; Iron; Photoelectron spectroscopy; Oxalic acid; Citric acid; magnetite; Pseudomonas fluorescens DO - http://dx.doi.org/10.1021/es048887c ER - TY - JOUR T1 - Record of redox status in laminated sediments from Lake Titicaca; a sulfur K-edge X-ray absorption near edge structure (XANES) study AN - 51701620; 2005-047901 AB - Laminated sediments are commonly used to examine limnological and ecological processes on short time scales. Here, we examine changes in sulfur speciation of lamination couplets from Lake Titicaca, South America using X-ray absorption near edge structure (XANES) spectroscopy. The dark-colored layer of each lamination couplet contains a significant fraction of reduced organic sulfides, with smaller fractions of iron sulfides and sulfate. In contrast, the light-colored layer of each couplet is primarily composed of sulfate. In all laminae, the sulfate is present as inorganic sulfate substituted in calcite. The differences in speciation likely reflect changes in productivity during sediment deposition. During the warm, productive summer months, micritic calcite precipitation was induced in oxidized surface waters due to pH changes induced by consumption of dissolved CO (sub 2) --this calcite incorporates dissolved sulfate and forms the light-colored layers. This pulse of productivity creates organic matter that partially decomposes during the austral winter months, consuming oxygen and delivering organic-rich sediment to the lake bottom. This decomposition, and the possible presence of a halocline, kept bottom waters low in oxygen, and lead to the production of organic matter rich in reduced sulfur. These data suggest that these laminations are deposited annually and illustrate the utility of S K-edge XANES for the analysis of laminated sediments. Abstract Copyright (2005) Elsevier, B.V. JF - Chemical Geology AU - Bostick, Benjamin C AU - Theissen, K M AU - Dunbar, R B AU - Vairavamurthy, M A Y1 - 2005/06/15/ PY - 2005 DA - 2005 Jun 15 SP - 163 EP - 174 PB - Elsevier, Amsterdam VL - 219 IS - 1-4 SN - 0009-2541, 0009-2541 KW - X-ray diffraction data KW - isotopes KW - Lake Titicaca KW - Holocene KW - environmental analysis KW - carbon dioxide KW - Bolivia KW - XANES spectra KW - Cenozoic KW - radioactive isotopes KW - dates KW - carbon KW - sediments KW - absolute age KW - Peru KW - spectra KW - depositional environment KW - chemical composition KW - sedimentary structures KW - geochemistry KW - pH KW - Eh KW - monitoring KW - Quaternary KW - sulfates KW - laminations KW - sedimentation KW - solutes KW - X-ray spectra KW - South America KW - planar bedding structures KW - organic compounds KW - lacustrine environment KW - sulfur KW - seasonal variations KW - C-14 KW - SEM data KW - lake sediments KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51701620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Geology&rft.atitle=Record+of+redox+status+in+laminated+sediments+from+Lake+Titicaca%3B+a+sulfur+K-edge+X-ray+absorption+near+edge+structure+%28XANES%29+study&rft.au=Bostick%2C+Benjamin+C%3BTheissen%2C+K+M%3BDunbar%2C+R+B%3BVairavamurthy%2C+M+A&rft.aulast=Bostick&rft.aufirst=Benjamin&rft.date=2005-06-15&rft.volume=219&rft.issue=1-4&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Chemical+Geology&rft.issn=00092541&rft_id=info:doi/10.1016%2Fj.chemgeo.2005.02.004 L2 - http://www.sciencedirect.com/science/journal/00092541 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 42 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2014-03-14 N1 - CODEN - CHGEAD N1 - SubjectsTermNotLitGenreText - absolute age; Bolivia; C-14; carbon; carbon dioxide; Cenozoic; chemical composition; chemical fractionation; dates; depositional environment; Eh; environmental analysis; geochemistry; Holocene; isotopes; lacustrine environment; lake sediments; Lake Titicaca; laminations; monitoring; organic compounds; Peru; pH; planar bedding structures; Quaternary; radioactive isotopes; seasonal variations; sedimentary structures; sedimentation; sediments; SEM data; solutes; South America; spectra; sulfates; sulfur; X-ray diffraction data; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.1016/j.chemgeo.2005.02.004 ER - TY - JOUR T1 - Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme AN - 17545960; 6407241 AB - Clostridial neurotoxins comprising the seven serotypes of botulinum neurotoxins and tetanus neurotoxin are the most potent toxins known to humans. Their potency coupled with their specificity and selectivity underscores the importance in understanding their mechanism of action in order to develop a strategy for designing counter measures against them. To develop an effective vaccine against the toxin, it is imperative to achieve an inactive form of the protein which preserves the overall conformation and immunogenicity. Inactive mutants can be achieved either by targeting active site residues or by modifying the surface charges farther away from the active site. The latter affects the long-range forces such as electrostatic potentials in a subtle way without disturbing the structural integrity of the toxin causing some drastic changes in the activity/environment. Here we report structural and biochemical analysis on several mutations on Clostridium botulinum neurotoxin type E light chain with at least two producing dramatic effects: Glu335Gln causes the toxin to transform into a persistent apoenzyme devoid of zinc, and Tyr350Ala has no hydrolytic activity. The structural analysis of several mutants has led to a better understanding of the catalytic mechanism of this family of proteins. The residues forming the S1' subsite have been identified by comparing this structure with a thermolysin-inhibitor complex structure. JF - Biochemistry (Washington) AU - Agarwal, R AU - Binz, T AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA Y1 - 2005/06/14/ PY - 2005 DA - 2005 Jun 14 SP - 8291 EP - 8302 VL - 44 IS - 23 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Light chains KW - Serotypes KW - Apoenzymes KW - Biochemical analysis KW - Clostridium botulinum KW - Tetanus KW - Toxins KW - Structure-function relationships KW - Immunogenicity KW - Zinc KW - Vaccines KW - Neurotoxins KW - Mutation KW - J 02822:Biosynthesis and physicochemical properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17545960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Analysis+of+Active+Site+Residues+of+Botulinum+Neurotoxin+E+by+Mutational%2C+Functional%2C+and+Structural+Studies%3A+Glu335Gln+Is+an+Apoenzyme&rft.au=Agarwal%2C+R%3BBinz%2C+T%3BSwaminathan%2C+S&rft.aulast=Agarwal&rft.aufirst=R&rft.date=2005-06-14&rft.volume=44&rft.issue=23&rft.spage=8291&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi050253a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Clostridium botulinum; Neurotoxins; Toxins; Apoenzymes; Immunogenicity; Structure-function relationships; Serotypes; Light chains; Biochemical analysis; Vaccines; Tetanus; Zinc; Mutation DO - http://dx.doi.org/10.1021/bi050253a ER - TY - JOUR T1 - Structural analysis of the catalytic domain of tetanus neurotoxin AN - 19957483; 6658931 AB - Clostridium neurotoxins, comprising the tetanus neurotoxin and the seven antigenically distinct botulinum neurotoxins (BoNT/A-G), are among the known most potent bacterial protein toxins to humans. Although they have similar function, sequences and three-dimensional structures, the substrate specificity and the selectivity of peptide bond cleavage are different and unique. Tetanus and botulinum type B neurotoxins enzymatically cleave the same substrate, vesicle-associated membrane protein, at the same peptide bond though the optimum length of substrate peptide required for cleavage by them is different. Here, we present the first experimentally determined three-dimensional structure of the catalytic domain of tetanus neurotoxin and analyze its active site. The structure provides insight into the active site of tetanus toxin's proteolytic activity and the importance of the nucleophilic water and the role of the zinc ion. The probable reason for different modes of binding of vesicle-associated membrane protein to botulinum neurotoxin type B and the tetanus toxin is discussed. The structure provides a basis for designing a novel recombinant vaccine or structure-based drugs for tetanus. JF - Toxicon AU - Rao, Krishnamurthy N AU - Kumaran, Desigan AU - Binz, Thomas AU - Swaminathan, Subramanyam AD - Brookhaven National Laboratory, Biology Department, 50 Bell Avenue, Upton, NY 11973, USA, swami@bnl.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 929 EP - 939 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 45 IS - 7 SN - 0041-0101, 0041-0101 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Clostridium neurotoxin KW - Tetanus neurotoxin KW - Botulinum neurotoxin KW - Zinc KW - Metalloprotease KW - Dual-wavelength anomalous diffraction (DAD) KW - X-ray structure KW - Proteolysis KW - Clostridium KW - Substrate specificity KW - Membrane proteins KW - tetanus toxin KW - Vaccines KW - Botulinum toxin KW - Neurotoxins KW - Tetanus KW - Drugs KW - X 24171:Microbial KW - N3 11028:Neuropharmacology & toxicology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19957483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Structural+analysis+of+the+catalytic+domain+of+tetanus+neurotoxin&rft.au=Rao%2C+Krishnamurthy+N%3BKumaran%2C+Desigan%3BBinz%2C+Thomas%3BSwaminathan%2C+Subramanyam&rft.aulast=Rao&rft.aufirst=Krishnamurthy&rft.date=2005-06-01&rft.volume=45&rft.issue=7&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2005.02.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Proteolysis; Zinc; Substrate specificity; Botulinum toxin; Vaccines; tetanus toxin; Membrane proteins; Tetanus; Neurotoxins; Drugs; Clostridium DO - http://dx.doi.org/10.1016/j.toxicon.2005.02.032 ER - TY - JOUR T1 - Chemical evolution of an isolated power plant plume during the TexAQS 2000 study AN - 16200456; 6451621 AB - Stack emissions from a coal-burning power plant were measured during a research flight of the DOE G-1 during the Texas Air Quality Study (TexAQS 2000) on 10 September 2000. Clean upstream air and an isolated location allowed the plume to be unambiguously sampled during 12 successive downwind transects to a distance of 63 km; corresponding to a processing time of 4.6 h. The chemical transformation rates of sulfur and nitrogen primary pollutants into aerosol SO, and HNO, sub(3), yield independent values of OH concentration (8.0 and, 11x10, cm, super(-3), respectively) that are consistent within experimental uncertainty and qualitatively agree with constrained steady-state (CSS) box model calculations. Ozone production efficiency increases with plume age as expected. Primary aerosol emissions with, D sub(p)>5, , mu , m were sampled near the stack. As the plume ages, aerosol size distributions adjusted for dilution show constant number concentrations of aerosols, D sub(p)>10, nm and a marked increase in accumulation-mode particles (, D sub(p)>0.1, , mu , m) as gas-to-particle-conversion causes smaller particles to grow. JF - Atmospheric Environment AU - Springston AU - Kleinman, LI AU - Brechtel, F AU - Lee, Y-N AU - Nunnermacker, L J AU - Wang, J AD - Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 3431 EP - 3443 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 39 IS - 19 SN - 1352-2310, 1352-2310 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Power-plant plume KW - Texas 2000 Air Quality Study KW - Aerosol growth KW - Airborne measurements KW - Sulfur KW - Aerosols KW - Atmospheric pollution models KW - Sulfur in aerosols KW - Air quality KW - Particulates KW - Stack emissions KW - Plume models KW - Ozone production KW - Aerosol size distribution KW - Atmospheric chemistry KW - Power plants KW - Chemical transformation KW - USA, Texas KW - Plumes KW - Wind KW - Evolution KW - Nitrogen KW - Ozone KW - Plume dispersion KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16200456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Chemical+evolution+of+an+isolated+power+plant+plume+during+the+TexAQS+2000+study&rft.au=Springston%3BKleinman%2C+LI%3BBrechtel%2C+F%3BLee%2C+Y-N%3BNunnermacker%2C+L+J%3BWang%2C+J&rft.aulast=Chen&rft.aufirst=J&rft.date=2005-12-01&rft.volume=86&rft.issue=52%2C+SUPPL.&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-10-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Plume models; Ozone production; Sulfur in aerosols; Atmospheric pollution models; Aerosol size distribution; Atmospheric chemistry; Chemical transformation; Air quality; Evolution; Plume dispersion; Sulfur; Aerosols; Power plants; Particulates; Stack emissions; Plumes; Wind; Ozone; Nitrogen; USA, Texas DO - http://dx.doi.org/10.1016/j.atmosenv.2005.01.060 ER - TY - JOUR T1 - Long-Term Verification of Cover Systems Using Perfluorocarbon Tracers AN - 16188161; 6248807 AB - The expanded use of caps and cover systems is an important aspect of the U.S. Department of Energy Environmental Management's strategy for restoration and long-term stewardship of sites throughout the complex. However, very little is available in terms of long-term monitoring of covers other than downstream groundwater or surface water monitoring. A novel methodology for verifying and monitoring subsurface barriers and cover systems has been developed. Gaseous perfluorocarbon tracers (PFTs) are injected on one side of the barrier and searched for on the opposite side of the barrier. The capability for leak detection in subsurface barriers using PFTs has been proven at multiple demonstrations. Adaptation of this concept to covers is a necessary step prior to full-scale demonstration. This paper discusses the PFT technology and a successful proof-of-principle test of the PFT technology as a leak detection tool for cover verification and monitoring. JF - Journal of Environmental Engineering AU - Heiser, J AU - Sullivan, T AU - Serrato, M AD - Environmental Sciences Dept., Environmental Research and Technology Division, Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 952 EP - 960 VL - 131 IS - 6 SN - 0733-9372, 0733-9372 KW - perfluorocarbons KW - subsurface KW - Pollution Abstracts KW - Environmental monitoring KW - Disposal sites KW - Tracers KW - Permeability KW - USA KW - Leak detection KW - Gases KW - Containment KW - Environment management KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16188161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Flow+banding+in+rhyolites%3B+a+manifestation+of+water+concentration+heterogeneity+in+the+melt%3F&rft.au=Seaman%2C+S+J%3BDyar%2C+D%3BMarinkovic%2C+N%3BAnonymous&rft.aulast=Levine&rft.aufirst=Kate&rft.date=2016-06-01&rft.volume=116&rft.issue=5&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Columbia+Law+Review&rft.issn=00101958&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-08-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Disposal sites; Environmental monitoring; Permeability; Tracers; Gases; Leak detection; Containment; Environment management; USA DO - http://dx.doi.org/10.1061/(ASCE)0733-9372(2005)131:6(952) ER - TY - JOUR T1 - Crystal Structure of the N-terminal Domain of the Group B Streptococcus Alpha C Protein AN - 17498386; 6274661 AB - Group B Streptococcus (GBS) is the leading cause of bacterial pneumonia, sepsis, and meningitis among neonates and an important cause of morbidity among pregnant women and immunocompromised adults. Invasive diseases due to GBS are attributed to the ability of the pathogen to translocate across human epithelial surfaces. The alpha C protein (ACP) has been identified as an invasin that plays a role in internalization and translocation of GBS across epithelial cells. The soluble N-terminal domain of ACP (NtACP) blocks the internalization of GBS. We determined the 1.86-Aa resolution crystal structure of NtACP comprising residues Ser super(52) through Leu super(225) of the full-length ACP. NtACP has two domains, an N-terminal beta -sandwich and a C-terminal three-helix bundle. Structural and topological alignments reveal that the beta -sandwich shares structural elements with the type III fibronectin fold (FnIII), but includes structural elaborations that make it unique. We have identified a potential integrin-binding motif consisting of Lys-Thr-Asp super(146), Arg super(110), and Asp super(118). A similar arrangement of charged residues has been described in other invasins. ACP shows a heparin binding activity that requires NtACP. We propose a possible heparin-binding site, including one surface of the three-helix bundle, and nearby portions of the sandwich and repeat domains. We have validated this prediction using assays of the heparin binding and cell-adhesion properties of engineered fragments of ACP. This is the first crystal structure of a member of the highly conserved Gram-positive surface alpha-like protein family, and it will enable the internalization mechanism of GBS to be dissected at the atomic level. JF - Journal of Biological Chemistry AU - Auperin, Thierry C AU - Bolduc, Gilles R AU - Baron, Miriam J AU - Heroux, Annie AU - Filman, David J AU - Madoff, Lawrence C AU - Hogle, James M AD - Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, the Brigham and Women's Hospital, Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, and the Biology Department, 463, Brookhaven National Laboratory, Upton, New York 11973-5000 Y1 - 2005/05/06/ PY - 2005 DA - 2005 May 06 SP - 18245 EP - 18252 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 18 SN - 0021-9258, 0021-9258 KW - streptococci KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Epithelial cells KW - Fibronectin KW - protein families KW - Pathogens KW - Morbidity KW - Meningitis KW - Sepsis KW - Crystal structure KW - double prime C protein KW - Neonates KW - Translocation KW - Heparin KW - Pneumonia KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17498386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Crystal+Structure+of+the+N-terminal+Domain+of+the+Group+B+Streptococcus+Alpha+C+Protein&rft.au=Auperin%2C+Thierry+C%3BBolduc%2C+Gilles+R%3BBaron%2C+Miriam+J%3BHeroux%2C+Annie%3BFilman%2C+David+J%3BMadoff%2C+Lawrence+C%3BHogle%2C+James+M&rft.aulast=Auperin&rft.aufirst=Thierry&rft.date=2005-05-06&rft.volume=280&rft.issue=18&rft.spage=18245&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Fibronectin; protein families; Pathogens; Morbidity; Meningitis; Sepsis; Crystal structure; double prime C protein; Neonates; Heparin; Translocation; Pneumonia; Streptococcus ER - TY - JOUR T1 - Health physics challenges involved with opening a "seventeen-inch" concrete waste vault. AN - 67734344; 15824590 AB - This paper describes the various activities involved with opening a sealed legacy "Seventeen-inch" concrete vault and the health physics challenges and solutions employed. As part of a legacy waste stream that was removed from the former Hazardous Waste Management Facility at Brookhaven National Laboratory, the "Seventeen-inch" concrete vault labeled 1-95 was moved to the new Waste Management Facility for ultimate disposal. Because the vault contained 239Pu foils with a total activity in excess of the transuranic waste limits, the foils needed to be removed and repackaged for disposal. Conventional diamond wire saws could not be used because of facility constraints, so this project relied mainly on manual techniques. The planning and engineering controls put in place enabled personnel to open the vault and remove the waste while keeping dose as low as reasonably achievable. JF - Health physics AU - Sullivan, Patrick T AU - Pizzulli, Michelle AD - Radiological Control Division, Brookhaven National Laboratory, PO Box 5000, Building 860, Upton, NY 11973, USA. sulli@bnl.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - S97 EP - S103 VL - 88 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Radioactive Waste KW - 0 KW - Index Medicus KW - United States KW - Environmental Pollution -- prevention & control KW - Radiation Dosage KW - Risk Factors KW - Equipment Failure Analysis -- methods KW - Risk Assessment -- standards KW - Risk Assessment -- methods KW - Radiation Monitoring -- methods KW - Safety Management -- standards KW - Radioactive Waste -- prevention & control KW - Radiation Protection -- instrumentation KW - Radiation Protection -- standards KW - Decontamination -- methods KW - Radiation Monitoring -- standards KW - Radiation Protection -- methods KW - Decontamination -- instrumentation KW - Safety Management -- methods KW - Waste Management -- instrumentation KW - Health Physics -- methods KW - Health Physics -- instrumentation KW - Waste Management -- methods KW - Waste Management -- standards KW - Decontamination -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67734344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Health+physics+challenges+involved+with+opening+a+%22seventeen-inch%22+concrete+waste+vault.&rft.au=Sullivan%2C+Patrick+T%3BPizzulli%2C+Michelle&rft.aulast=Sullivan&rft.aufirst=Patrick&rft.date=2005-05-01&rft.volume=88&rft.issue=5+Suppl&rft.spage=S97&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-10 N1 - Date created - 2005-04-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Temperature-resolved synchrotron X-ray diffraction study of dehydration of birnessite-like phases AN - 51613077; 2006-024323 JF - Geochimica et Cosmochimica Acta AU - Post, Jeffrey E AU - Heaney, P J AU - Hanson, J AU - Anonymous Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 627 PB - Pergamon, Oxford VL - 69 IS - 10, Suppl. SN - 0016-7037, 0016-7037 KW - mineral interlayer KW - experimental studies KW - X-ray diffraction data KW - crystal structure KW - Rietveld refinement KW - temperature KW - synchrotron radiation KW - laboratory studies KW - birnessite KW - oxides KW - cations KW - dehydration KW - synthesis KW - crystal chemistry KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51613077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Temperature-resolved+synchrotron+X-ray+diffraction+study+of+dehydration+of+birnessite-like+phases&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+P+J%3BHanson%2C+J%3BAnonymous&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2005-05-01&rft.volume=69&rft.issue=10%2C+Suppl.&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 15th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - birnessite; cations; crystal chemistry; crystal structure; dehydration; experimental studies; laboratory studies; mineral interlayer; oxides; Rietveld refinement; synchrotron radiation; synthesis; temperature; X-ray diffraction data ER - TY - JOUR T1 - Speciation and surface complexation of As on hydrous ferric oxide in soils modified by in situ chemical fixation AN - 51610338; 2006-024301 JF - Geochimica et Cosmochimica Acta AU - Donahoe, R J AU - Yang, L AU - Lanzirotti, A AU - Anonymous Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 616 PB - Pergamon, Oxford VL - 69 IS - 10, Suppl. SN - 0016-7037, 0016-7037 KW - hydrates KW - iron oxides KW - X-ray diffraction data KW - complexing KW - iron KW - soil sampling KW - XANES spectra KW - synchrotron radiation KW - ferric iron KW - oxides KW - spectra KW - geochemistry KW - soils KW - toxic materials KW - fixation KW - experimental studies KW - herbicides KW - arsenic KW - soil treatment KW - pollution KW - X-ray spectra KW - sample preparation KW - soil pollution KW - metals KW - EXAFS data KW - pesticides KW - leaching KW - SEM data KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51610338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Speciation+and+surface+complexation+of+As+on+hydrous+ferric+oxide+in+soils+modified+by+in+situ+chemical+fixation&rft.au=Donahoe%2C+R+J%3BYang%2C+L%3BLanzirotti%2C+A%3BAnonymous&rft.aulast=Donahoe&rft.aufirst=R&rft.date=2005-05-01&rft.volume=69&rft.issue=10%2C+Suppl.&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 15th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - arsenic; chemical fractionation; complexing; EXAFS data; experimental studies; ferric iron; fixation; geochemistry; herbicides; hydrates; iron; iron oxides; leaching; metals; oxides; pesticides; pollution; sample preparation; SEM data; soil pollution; soil sampling; soil treatment; soils; spectra; synchrotron radiation; toxic materials; X-ray diffraction data; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Transformation of arsenic species in solids and porewaters from Yellowknife Bay, NWT, Canada AN - 51609990; 2006-024302 JF - Geochimica et Cosmochimica Acta AU - Andrade, C F AU - Jamieson, H E AU - Walker, S R AU - Lanzirotti, A AU - Praharaj, T AU - Fortin, D AU - Anonymous Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 616 PB - Pergamon, Oxford VL - 69 IS - 10, Suppl. SN - 0016-7037, 0016-7037 KW - Great Slave Lake KW - XANES spectra KW - Yellowknife Northwest Territories KW - sediments KW - X-ray fluorescence spectra KW - spectra KW - geochemistry KW - Eh KW - Yellowknife Bay KW - liquid phase KW - hydrology KW - arsenic KW - pollution KW - X-ray spectra KW - Northwest Territories KW - geochemical cycle KW - solid phase KW - limnology KW - Canada KW - metals KW - lacustrine environment KW - Western Canada KW - seasonal variations KW - transformations KW - aquatic environment KW - pore water KW - microorganisms KW - lake sediments KW - chemical fractionation KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51609990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Transformation+of+arsenic+species+in+solids+and+porewaters+from+Yellowknife+Bay%2C+NWT%2C+Canada&rft.au=Andrade%2C+C+F%3BJamieson%2C+H+E%3BWalker%2C+S+R%3BLanzirotti%2C+A%3BPraharaj%2C+T%3BFortin%2C+D%3BAnonymous&rft.aulast=Andrade&rft.aufirst=C&rft.date=2005-05-01&rft.volume=69&rft.issue=10%2C+Suppl.&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 15th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - aquatic environment; arsenic; Canada; chemical fractionation; Eh; geochemical cycle; geochemistry; Great Slave Lake; hydrology; lacustrine environment; lake sediments; limnology; liquid phase; metals; microorganisms; Northwest Territories; pollution; pore water; seasonal variations; sediments; solid phase; spectra; transformations; Western Canada; X-ray fluorescence spectra; X-ray spectra; XANES spectra; Yellowknife Bay; Yellowknife Northwest Territories ER - TY - JOUR T1 - N-terminal helix reorients in recombinant C-fragment of Clostridium botulinum type B. AN - 67529524; 15781237 AB - Botulinum neurotoxins comprise seven distinct serotypes (A-G) produced by Clostridium botulinum. The crystal structure of the binding domain of the botulinum neurotoxin type B (BBHc) has been determined to 2A resolution. The overall structure of BBHc is well ordered and similar to that of the binding domain of the holotoxin. However, significant structural changes occur at what would be the interface of translocation and binding domains of the holotoxin. The loop 911-924 shows a maximum displacement of 14.8A at the farthest point. The N-terminal helix reorients and moves by 19.5A from its original position. BBHc is compared with the binding domain of the holotoxin of botulinum type A and B, and the tetanus C-fragment to characterize the heavy chain-carbohydrate interactions. The probable reasons for different binding affinity of botulinum and tetanus toxins are discussed. JF - Biochemical and biophysical research communications AU - Jayaraman, Seetharaman AU - Eswaramoorthy, Subramaniam AU - Ahmed, S Ashraf AU - Smith, Leonard A AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2005/04/29/ PY - 2005 DA - 2005 Apr 29 SP - 97 EP - 103 VL - 330 IS - 1 SN - 0006-291X, 0006-291X KW - Carbohydrates KW - 0 KW - Recombinant Proteins KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Index Medicus KW - Models, Molecular KW - Carbohydrates -- chemistry KW - Crystallography, X-Ray KW - Recombinant Proteins -- chemistry KW - Protein Conformation KW - Botulinum Toxins -- chemistry KW - Clostridium botulinum -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67529524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=N-terminal+helix+reorients+in+recombinant+C-fragment+of+Clostridium+botulinum+type+B.&rft.au=Jayaraman%2C+Seetharaman%3BEswaramoorthy%2C+Subramaniam%3BAhmed%2C+S+Ashraf%3BSmith%2C+Leonard+A%3BSwaminathan%2C+Subramanyam&rft.aulast=Jayaraman&rft.aufirst=Seetharaman&rft.date=2005-04-29&rft.volume=330&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-26 N1 - Date created - 2005-03-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Imaging addiction with PET: is insight in sight? AN - 67752038; 15837598 AB - Neurochemical imaging studies can identify molecular targets of abused drugs and link them to the underlying pathology associated with behaviors such as drug dependence, addiction and withdrawal. positron emission tomography (PET) is opening new avenues for the investigation of the neurochemical disturbances underlying drug abuse and addiction and the in vivo mechanisms by which medications might ameliorate these conditions. PET can identify vulnerable human populations, treatment strategies and monitor treatment efficacy. Thus, with this tool and the knowledge it provides, the potential for developing novel drugs and treatment strategies for drug addiction is now close at hand. JF - Drug discovery today AU - Schiffer, Wynne K AU - Lee, Dianne E AU - Brodie, Jonathan D AU - Dewey, Stephen L AD - Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794, USA. wynne@bnl.gov Y1 - 2005/04/15/ PY - 2005 DA - 2005 Apr 15 SP - 547 EP - 562 VL - 10 IS - 8 SN - 1359-6446, 1359-6446 KW - Index Medicus KW - Animals KW - Humans KW - Forecasting KW - Terminology as Topic KW - Substance-Related Disorders -- diagnosis KW - Positron-Emission Tomography -- instrumentation KW - Positron-Emission Tomography -- utilization KW - Positron-Emission Tomography -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67752038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+discovery+today&rft.atitle=Imaging+addiction+with+PET%3A+is+insight+in+sight%3F&rft.au=Schiffer%2C+Wynne+K%3BLee%2C+Dianne+E%3BBrodie%2C+Jonathan+D%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2005-04-15&rft.volume=10&rft.issue=8&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Drug+discovery+today&rft.issn=13596446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-29 N1 - Date created - 2005-04-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Methylmercury, fish consumption, and the precautionary principle. AN - 67822943; 15887881 AB - This paper considers several broad issues in the context of probabilistic assessment of the benefits of curtailing mercury (Hg) emissions from U.S. coal-fired power plants, based on information developed from recent literature and epidemiology studies of health effects of methylmercury. Exposure of the U.S. population is considered on the national scale, in large part because of recent questions arising from survey and experimental data about the relative importance of local deposition of airborne Hg. Although epidemiological studies have provided useful information, safe levels of Hg exposure remain uncertain, in part because of other dietary considerations in the populations that were studied. For example, much of the seafood consumed in one of the major studies was also contaminated with polychlorinated biphenyls, as are fish taken from some U.S. fresh waters. The primary epidemiological approach involves cross-study comparisons in relation to mean exposures, rather than detailed critiques of individual effects reported in each study. U.S. exposures are seen to be well below the levels at which adverse health effects are reported. This analysis supports the conclusion that unilateral reduction of Hg emissions from U.S. coal-fired power plants alone is unlikely to realize significant public health benefits. JF - Journal of the Air & Waste Management Association (1995) AU - Lipfert, Fred AU - Morris, Sam AU - Sullivan, Terry AU - Moskowitz, Paul AU - Renninger, Scott AD - Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 388 EP - 398 VL - 55 IS - 4 SN - 1096-2247, 1096-2247 KW - Coal KW - 0 KW - Methylmercury Compounds KW - Index Medicus KW - Animals KW - Incineration KW - Public Health KW - Air Pollution -- prevention & control KW - Power Plants KW - Humans KW - Fishes KW - Diet KW - Risk Assessment KW - Methylmercury Compounds -- poisoning KW - Food Contamination KW - Seafood KW - Methylmercury Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67822943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association+%281995%29&rft.atitle=Methylmercury%2C+fish+consumption%2C+and+the+precautionary+principle.&rft.au=Lipfert%2C+Fred%3BMorris%2C+Sam%3BSullivan%2C+Terry%3BMoskowitz%2C+Paul%3BRenninger%2C+Scott&rft.aulast=Lipfert&rft.aufirst=Fred&rft.date=2005-04-01&rft.volume=55&rft.issue=4&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association+%281995%29&rft.issn=10962247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-03 N1 - Date created - 2005-05-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Multidomain synthetic peptide B2A2 synergistically enhances BMP-2 in vitro. AN - 67507987; 15765189 AB - UNLABELLEDA multidomain, synthetic peptide designated B2A2 synergizes the activity of BMP-2. B2A2 interacts with BMP receptor isoforms, potentiating the action of BMP-2 in activating alkaline phosphatase and triggering Smad and MAPK signaling. B2A2's design permits its delivery as a local surface coating as well as a soluble co-factor, thus broadening potential bioengineering applications.INTRODUCTIONBMP-2 induces osteogenic differentiation and accelerates bone repair. Although BMP-2 inhibitors have been discovered, no BMP-2 mimetics or enhancers that function in the physiological range have yet been found. Here we report that a synthetic peptide designated B2A2, consisting of (1) a BMP receptor-targeting sequence, (2) a hydrophobic spacer, and (3) a heparin-binding sequence, is a positive modulator of recombinant BMP-2.MATERIALS AND METHODSCultures of mesenchymal cell lines C2C12 and C3H10T1/2 were given B2A2, recombinant BMP-2, or both. Alkaline phosphatase (ALP) activity was assayed by conversion of paranitrophenol phosphate (PNPP). Signaling through Smad and MAP kinase pathways was monitored by Western blot. Receptor binding was assessed by incubating immobilized B2A2 with soluble recombinant receptor-Fc chimeras and detecting bound receptor by anti-Fc antibody ELISA. Surface coating of medical device materials was done by first dip-coating with silyl-heparin, followed by B2A2.RESULTS AND CONCLUSIONSTreatment of cells with B2A2 alone marginally increased ALP activity. However, B2A2 plus BMP-2 resulted in 5- to 40-fold augmentation of ALP compared with BMP-2 alone in C3H10T1/2 or C2C12 cells, respectively. This synergistic enhancement was observed over a broad concentration range (4-1000 ng/ml BMP-2). B2A2 interacted directly with BMP receptor isoforms (preferentially to BMPR-Ib and ActivinR-II). In cells, B2A2 + BMP-2 led to a repression of MAP kinase and an increase of Smad activation, consistent with known activation pathways of BMP-2. B2A2 was ineffective when paired with other cytokine/growth factors (basic fibroblast growth factor [FGF-2], TGF-beta1, vascular endothelial growth factor [VEGF]). Simultaneous co-administration was not strictly required. Pulse-chase experiments revealed that temporal separations up to 1 h were still effective. B2A2 was also effective when delivered in a polystyrene- or stainless steel-coated surface through a heparin platform (silyl-heparin) while BMP-2 was added exogenously in solution. These results suggest that B2A2 might promote aggregation of receptor subunits, enabling BMP-2 to activate signaling pathways at effectively lower concentrations. Synthetic multidomain constructs like B2A2 may be useful to accelerate bone repair/deposition through augmentation of endogenous levels of BMP-2 or through local BMP-2 contained in artificial or engineered matrices. JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Lin, Xinhua AU - Zamora, Paul O AU - Albright, Sarah AU - Glass, John D AU - Peña, Louis A AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 693 EP - 703 VL - 20 IS - 4 SN - 0884-0431, 0884-0431 KW - B2A2 peptide KW - 0 KW - BMP2 protein, human KW - Bmp2 protein, mouse KW - Bone Morphogenetic Protein 2 KW - Bone Morphogenetic Proteins KW - Peptides KW - Protein Isoforms KW - Transforming Growth Factor beta KW - Mitogen-Activated Protein Kinase 3 KW - EC 2.7.11.24 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Index Medicus KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Animals KW - Down-Regulation KW - Cells, Cultured KW - Humans KW - Mice KW - Alkaline Phosphatase -- metabolism KW - Protein Isoforms -- pharmacology KW - Drug Synergism KW - Cricetinae KW - Transforming Growth Factor beta -- pharmacology KW - Bone Morphogenetic Proteins -- pharmacology KW - Peptides -- chemistry KW - Peptides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67507987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Multidomain+synthetic+peptide+B2A2+synergistically+enhances+BMP-2+in+vitro.&rft.au=Lin%2C+Xinhua%3BZamora%2C+Paul+O%3BAlbright%2C+Sarah%3BGlass%2C+John+D%3BPe%C3%B1a%2C+Louis+A&rft.aulast=Lin&rft.aufirst=Xinhua&rft.date=2005-04-01&rft.volume=20&rft.issue=4&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-21 N1 - Date created - 2005-03-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Soil manganese oxides and trace metals; competitive sorption and microfocused synchrotron-X-ray fluorescence mapping AN - 51614633; 2006-027325 AB - Trace metal accumulation by Mn in synthetic oxides and soil nodules has been attributed to specific adsorption and oxidation at Mn oxide surfaces, yet little is known about trace metal interactions with Mn in bulk soil. We investigated competitive effects of trace metal pretreatment on Cr oxidation in well-aerated, high-Mn soils, as well as accumulation of added Pb, Co, and Cu by soil Mn using microfocused synchrotron x-ray fluorescence (mu SXRF). Short-term equilibrations of divalent Mn, Co, Pb, Cu, and Ni with soil samples weighed to contain equivalent amounts of NH (sub 2) OH.HCl-extractable Mn resulted in substantial interference in Cr oxidation, confirming metal interactions with Cr-oxidizing sites on Mn oxide surfaces. Interference by Cu and Pb was greatest in samples likely to be low in competing sorbents, that is, low-pH soils and smaller samples of higher Mn soils, respectively. Strongest interference in Cr oxidation resulted from Mn and Co addition, suggesting specific affinity for soil Mn oxide surfaces, and was greatest in high-pH, high-Mn-valence soils previously shown to have the greatest Cr oxidation capacity. Nickel showed the weakest effect. Micro-SXRF scans revealed substantial spatial correlation of soil Mn with added Co and Pb, but Pb microdistribution was equally correlated with soil Fe. Only modest overlap of soil Mn with added Cu was observed. Our data suggest that specific affinity of Pb, Cu, and Ni for soil Mn oxides was weaker than that of Mn and Co. Higher Mn oxide valence may enhance sorption and subsequent oxidation of these oxidizable metals. JF - Soil Science Society of America Journal (Internet) AU - Negra, Christine AU - Ross, Donald S AU - Lanzirotti, Antonio Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 353 EP - 361 PB - Soil Science Society of America, Madison, WI VL - 69 IS - 2 SN - 0361-5995, 0361-5995 KW - United States KW - sorption KW - secondary structures KW - cobalt KW - copper KW - lead KW - mapping KW - manganese KW - spatial distribution KW - Eutrudepts KW - northwestern Vermont KW - chemical reactions KW - manganese oxides KW - X-ray analysis KW - oxides KW - applications KW - valency KW - sedimentary structures KW - geochemistry KW - synthetic materials KW - pH KW - chromium KW - soils KW - chemical analysis KW - X-ray fluorescence KW - oxidation KW - Vermont KW - concretions KW - Inceptisols KW - metals KW - X-ray spectroscopy KW - nickel KW - synchrotrons KW - trace metals KW - spectroscopy KW - 02C:Geochemistry of rocks, soils, and sediments KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51614633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+Science+Society+of+America+Journal+%28Internet%29&rft.atitle=Soil+manganese+oxides+and+trace+metals%3B+competitive+sorption+and+microfocused+synchrotron-X-ray+fluorescence+mapping&rft.au=Negra%2C+Christine%3BRoss%2C+Donald+S%3BLanzirotti%2C+Antonio&rft.aulast=Negra&rft.aufirst=Christine&rft.date=2005-04-01&rft.volume=69&rft.issue=2&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Soil+Science+Society+of+America+Journal+%28Internet%29&rft.issn=03615995&rft_id=info:doi/ L2 - http://soil.scijournals.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 48 N1 - PubXState - WI N1 - Document feature - illus. incl. 2 tables N1 - SuppNotes - Accessed on March 21, 2005 N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - applications; chemical analysis; chemical reactions; chromium; cobalt; concretions; copper; Eutrudepts; geochemistry; Inceptisols; lead; manganese; manganese oxides; mapping; metals; nickel; northwestern Vermont; oxidation; oxides; pH; secondary structures; sedimentary structures; soils; sorption; spatial distribution; spectroscopy; synchrotrons; synthetic materials; trace metals; United States; valency; Vermont; X-ray analysis; X-ray fluorescence; X-ray spectroscopy ER - TY - JOUR T1 - The crystal structures of synthetics Fe (sub 2) (SO (sub 4) ) (sub 3) (H (sub 2) O) (sub 5) and the type specimen of lausenite AN - 51722925; 2005-030915 AB - An iron sulphate of nominal composition Fe (sub 2) (SO (sub 4) ) (sub 3) (H (sub 2) O) (sub 5 ) was synthesized and its structure determined and refined by high-resolution synchrotron powder XRD. The structure consists of corrugated slabs in which iron octahedra are linked by sulphate tetrahedra in the monoclinic space group P2 (sub 1) /m, with a 10.711, b 11.085, c 5.5747 Aa, beta 98.853 degrees , V 654.0 Aa (super 3) , Z = 2. These results are compared with those for the type specimen of lausenite from Jerome, Arizona, which has a 10.679, b 11.053, c 5.567 Aa, beta 98.89 degrees . TG and DTA curves show that it is a pentahydrate, despite earlier reports that lausenite is a hexahydrate. It is considered that the synthetic material provides a structure determination for lausenite. JF - American Mineralogist AU - Majzlan, Juraj AU - Botez, Cristian AU - Stephens, Peter W Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 411 EP - 416 PB - Mineralogical Society of America, Washington, DC VL - 90 IS - 2-3 SN - 0003-004X, 0003-004X KW - United States KW - hydrates KW - Yavapai County Arizona KW - X-ray diffraction data KW - thermogravimetric analysis KW - sulfates KW - crystal systems KW - crystal structure KW - powder method KW - Jerome Arizona KW - iron KW - synchrotron radiation KW - metals KW - lausenite KW - Arizona KW - monoclinic system KW - lattice parameters KW - DTA data KW - crystallography KW - TGA data KW - synthetic materials KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51722925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=The+crystal+structures+of+synthetics+Fe+%28sub+2%29+%28SO+%28sub+4%29+%29+%28sub+3%29+%28H+%28sub+2%29+O%29+%28sub+5%29+and+the+type+specimen+of+lausenite&rft.au=Majzlan%2C+Juraj%3BBotez%2C+Cristian%3BStephens%2C+Peter+W&rft.aulast=Majzlan&rft.aufirst=Juraj&rft.date=2005-03-01&rft.volume=90&rft.issue=2-3&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/10.2138%2Fam.2005.1701 L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 2005-01-01 N1 - Number of references - 17 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - Arizona; crystal structure; crystal systems; crystallography; DTA data; hydrates; iron; Jerome Arizona; lattice parameters; lausenite; metals; monoclinic system; powder method; sulfates; synchrotron radiation; synthetic materials; TGA data; thermogravimetric analysis; United States; X-ray diffraction data; Yavapai County Arizona DO - http://dx.doi.org/10.2138/am.2005.1701 ER - TY - JOUR T1 - Crystal Structures of the BlaI Repressor from Staphylococcus aureus and Its Complex with DNA: Insights into Transcriptional Regulation of the bla and mec Operons AN - 17835300; 6169447 AB - The 14-kDa BlaI protein represses the transcription of blaZ, the gene encoding beta -lactamase. It is homologous to MecI, which regulates the expression of mecA, the gene encoding the penicillin binding protein PBP2a. These genes mediate resistance to beta -lactam antibiotics in staphylococci. Both repressors can bind either bla or mec DNA promoter-operator sequences. Regulated resistance genes are activated via receptor-mediated cleavage of the repressors. Cleavage is induced when beta -lactam antibiotics bind the extramembrane sensor of the sensor-transducer signaling molecules, BlaR1 or MecR1. The crystal structures of BlaI from Staphylococcus aureus, both in free form and in complex with 32 bp of DNA of the mec operator, have been determined to 2.0-and 2.7-Aa resolutions, respectively. The structure of MecI, also in free form and in complex with the bla operator, has been previously reported. Both repressors form homodimers, with each monomer composed of an N-terminal DNA binding domain of winged helix-turn-helix topology and a C- terminal dimerization domain. The structure of BlaI in complex with the mec operator shows a protein-DNA interface that is conserved between both mec and bla targets. The recognition helix alpha 3 interacts specifically with the conserved TACA/TGTA DNA binding motif. BlaI and, probably, MecI dimers bind to opposite faces of the mec DNA double helix in an up-and-down arrangement, whereas MecI and, probably, BlaI dimers bind to the same DNA face of bla promoter-operator DNA. This is due to the different spacing of mec and bla DNA binding sites. Furthermore, the flexibility of the dimeric proteins may make the C-terminal proteolytic cleavage site more accessible when the repressors are bound to DNA than when they are in solution, suggesting that the induction cascade involves bound rather than free repressor. JF - Journal of Bacteriology AU - Safo, Martin K AU - Zhao, Qixun AU - Ko, Tzu-Ping AU - Musayev, Faik N AU - Robinson, Howard AU - Scarsdale, Neel AU - Wang, Andrew H-J AU - Archer, Gordon L AD - Department of Medicinal Chemistry, School of Pharmacy and Institute for Structural Biology and Drug Discovery. Departments of Medicine and Microbiology/Immunology, Virginia Commonwealth University, Richmond, Virginia. Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei, Taiwan. Department of Biology, Brookhaven National Laboratory, Upton, New York Y1 - 2005/03/01/ PY - 2005 DA - 2005 Mar 01 SP - 1833 EP - 1844 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 187 IS - 5 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Proteolysis KW - Nucleotide sequence KW - Antibiotics KW - Operators KW - Crystal structure KW - Staphylococcus aureus KW - b-Lactam antibiotics KW - Transcription KW - Penicillin KW - ^b-Lactam antibiotics KW - Gene regulation KW - DNA KW - Operons KW - Repressors KW - BlaI protein KW - Signal transduction KW - J 02725:DNA KW - N 14045:Transcriptional regulation KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17835300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Crystal+Structures+of+the+BlaI+Repressor+from+Staphylococcus+aureus+and+Its+Complex+with+DNA%3A+Insights+into+Transcriptional+Regulation+of+the+bla+and+mec+Operons&rft.au=Safo%2C+Martin+K%3BZhao%2C+Qixun%3BKo%2C+Tzu-Ping%3BMusayev%2C+Faik+N%3BRobinson%2C+Howard%3BScarsdale%2C+Neel%3BWang%2C+Andrew+H-J%3BArcher%2C+Gordon+L&rft.aulast=Safo&rft.aufirst=Martin&rft.date=2005-03-01&rft.volume=187&rft.issue=5&rft.spage=1833&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; DNA; Repressors; Transcription; Operators; Crystal structure; Antibiotics; Gene regulation; b-Lactam antibiotics; Proteolysis; BlaI protein; Signal transduction; Nucleotide sequence; Operons; Penicillin; ^b-Lactam antibiotics ER - TY - JOUR T1 - Oxidizing behavior of soil manganese; interactions among abundance, oxidation state, and pH AN - 51752211; 2005-015456 AB - Due to their high degree of reactivity, Mn oxides in soil systems may exert a greater influence on trace metal chemistry than that suggested by their relatively low abundance. In particular, Mn is the only known oxidizer of trivalent Cr in soils. We investigated soil properties that influence the Cr oxidizing capacity of Mn oxides in eight well-aerated high Mn soils. Total and easily reducible Mn abundance were quantified by extraction with 1.5 M NH (sub 2) OH degrees HCl and 0.02 M hydroquinone. Relativeaverage Mn oxidation state in soil samples was determined by x-ray absorption near edge structure spectroscopy (Mn-XANES) main edge energy position. Soils ranged in percentage of NH (sub 2) OH.HCl-extractable Mn between 0.14 and 1.27, pH between 4.4 and 7.2, and percentage of C between 9.0 and 27.2. Manganese-XANES spectra showed that most of the study soils had a high Mn(IV)/Mn(III) ratio with edge energy position intermediate to that of a synthetic birnessite and a synthetic pyrolusite. In these high Mn soils, Mn-XANES edge energy was positively correlated with soil pH, suggesting a linear increase, over the normal range of soil pH, in the Mn(IV)/Mn(III) ratio of soil oxides. Soils with more total reducible Mn generally demonstrated greater net Cr(VI) production, but this pattern was moderated by soil pH and relative Mn oxidation state. High Mn soils with low pH and Mn oxidation state were weaker Cr oxidizers than their Mn abundance would suggest. Our data provide evidence that greater Mn abundance and greater Mn(IV)/Mn(III) ratio in soil Mn oxides enhances Cr oxidation. JF - Soil Science Society of America Journal AU - Negra, Christine AU - Ross, Donald S AU - Lanzirotti, Antonio Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 87 EP - 95 PB - Soil Science Society of America, Madison, WI VL - 69 IS - 1 SN - 0361-5995, 0361-5995 KW - United States KW - soils KW - experimental studies KW - oxidation KW - manganese KW - X-ray spectra KW - Vermont KW - XANES spectra KW - Eutrudepts KW - northwestern Vermont KW - Inceptisols KW - chemical reactions KW - quantitative analysis KW - metals KW - manganese oxides KW - oxides KW - spectra KW - geochemistry KW - pH KW - Eh KW - chromium KW - 02C:Geochemistry of rocks, soils, and sediments KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51752211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+Science+Society+of+America+Journal&rft.atitle=Oxidizing+behavior+of+soil+manganese%3B+interactions+among+abundance%2C+oxidation+state%2C+and+pH&rft.au=Negra%2C+Christine%3BRoss%2C+Donald+S%3BLanzirotti%2C+Antonio&rft.aulast=Negra&rft.aufirst=Christine&rft.date=2005-02-01&rft.volume=69&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Soil+Science+Society+of+America+Journal&rft.issn=03615995&rft_id=info:doi/ L2 - http://soil.scijournals.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 56 N1 - PubXState - WI N1 - Document feature - illus. incl. 3 tables N1 - SuppNotes - Accessed on February 2, 2005 N1 - Last updated - 2012-06-07 N1 - CODEN - SSSJD4 N1 - SubjectsTermNotLitGenreText - chemical reactions; chromium; Eh; Eutrudepts; experimental studies; geochemistry; Inceptisols; manganese; manganese oxides; metals; northwestern Vermont; oxidation; oxides; pH; quantitative analysis; soils; spectra; United States; Vermont; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Internal structure of type I deep-sea spherules by X-ray computed microtomography AN - 51691270; 2005-049748 AB - The internal structures of type I spherules (melted micrometeorites rich in iron) have been investigated using synchrotron-based computed microtomography. Variations from sphericity are small--the average ratio of the largest to the smallest semimajor axis is 1.07+ or -0.06. The X-ray tomographs reveal interior cavities, four spherules with metal cores with diameters ranging from 57 to 143 mu m and, in two spherules, high attenuation features thought to be nuggets rich in platinum-group elements. Bulk densities range from 4.2 to 5.9 g/cm (super 3) and average grain densities from 4.5 to 6.5 (g/cm (super 3) ) with uncertainties of 10-15%. The average grain densities are those expected for materials containing mostly oxides of iron and nickel. The tomographic density measurements indicate an average void space of 5 (super +8) (sub -5) %. The void spaces may be contraction features or the skeletons of bubbles that formed in the molten precursors during atmospheric passage. JF - Meteoritics & Planetary Science AU - Feng, H AU - Jones, K W AU - Tomov, S AU - Stewart, B AU - Herzog, G F AU - Schnabel, C AU - Brownlee, D E Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 195 EP - 206 PB - Meteoritical Society, Fayetteville, AR VL - 40 IS - 2 SN - 1086-9379, 1086-9379 KW - tomography KW - nuggets KW - iron oxides KW - density KW - iron-rich composition KW - deep-sea environment KW - platinum group KW - melts KW - iridium KW - synchrotron radiation KW - mass KW - meteorites KW - hematite KW - Pacific Basin KW - X-ray analysis KW - oxides KW - dimensions KW - spectra KW - wustite KW - spherules KW - bulk density KW - bubbles KW - X-ray spectra KW - porosity KW - micrometeorites KW - physical properties KW - contraction KW - computed tomography KW - microscope methods KW - metals KW - marine environment KW - Pacific Ocean KW - volume KW - scanning electron microscopy KW - magnetite KW - 05B:Petrology of meteorites and tektites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51691270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Meteoritics+%26+Planetary+Science&rft.atitle=Internal+structure+of+type+I+deep-sea+spherules+by+X-ray+computed+microtomography&rft.au=Feng%2C+H%3BJones%2C+K+W%3BTomov%2C+S%3BStewart%2C+B%3BHerzog%2C+G+F%3BSchnabel%2C+C%3BBrownlee%2C+D+E&rft.aulast=Feng&rft.aufirst=H&rft.date=2005-02-01&rft.volume=40&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Meteoritics+%26+Planetary+Science&rft.issn=10869379&rft_id=info:doi/ L2 - http://cavern.uark.edu/~meteor/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 36 N1 - PubXState - AR N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - MERTAW N1 - SubjectsTermNotLitGenreText - bubbles; bulk density; computed tomography; contraction; deep-sea environment; density; dimensions; hematite; iridium; iron oxides; iron-rich composition; magnetite; marine environment; mass; melts; metals; meteorites; micrometeorites; microscope methods; nuggets; oxides; Pacific Basin; Pacific Ocean; physical properties; platinum group; porosity; scanning electron microscopy; spectra; spherules; synchrotron radiation; tomography; volume; wustite; X-ray analysis; X-ray spectra ER - TY - JOUR T1 - LcrV Capture Enzyme-Linked Immunosorbent Assay for Detection of Yersinia pestis from Human Samples AN - 17774421; 6167137 AB - In the United States, there is currently a major gap in the diagnostic capabilities with regard to plague. To address this, we developed an antigen capture assay using an essential virulence factor secreted by Yersinia spp., LcrV, as the target antigen. We generated anti-LcrV monoclonal antibodies (MAbs) and screened them for the ability to bind bacterially secreted native Yersinia pestis LcrV. Anti-LcrV MAb 19.31 was used as a capture antibody, and biotinylated MAb 40.1 was used for detection. The detection limit of this highly sensitive Yersinia LcrV capture enzyme-linked immunosorbent assay is 0.1 ng/ml. The assay detected LcrV from human sputum and blood samples treated with concentrations as low as 0.5 ng/ml of bacterially secreted native Y. pestis LcrV. This assay could be used as a tool to help confirm the diagnosis of plague in patients presenting with pneumonia. JF - Clinical and Diagnostic Laboratory Immunology AU - Gomes-Solecki, Maria JC AU - Savitt, Anne G AU - Rowehl, Rebecca AU - Glass, John D AU - Bliska, James B AU - Dattwyler, Raymond J AD - Center for Infectious Diseases. Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook. Brookhaven National Laboratory, Upton, New York Y1 - 2005/02// PY - 2005 DA - Feb 2005 SP - 339 EP - 346 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 12 IS - 2 SN - 1071-412X, 1071-412X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - virulence factors KW - Monoclonal antibodies KW - LcrV protein KW - Yersinia pestis KW - Sputum KW - Plague KW - Pneumonia KW - J 02831:Techniques and reagents KW - F 06720:ELISA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17774421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Diagnostic+Laboratory+Immunology&rft.atitle=LcrV+Capture+Enzyme-Linked+Immunosorbent+Assay+for+Detection+of+Yersinia+pestis+from+Human+Samples&rft.au=Gomes-Solecki%2C+Maria+JC%3BSavitt%2C+Anne+G%3BRowehl%2C+Rebecca%3BGlass%2C+John+D%3BBliska%2C+James+B%3BDattwyler%2C+Raymond+J&rft.aulast=Gomes-Solecki&rft.aufirst=Maria&rft.date=2005-02-01&rft.volume=12&rft.issue=2&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Diagnostic+Laboratory+Immunology&rft.issn=1071412X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Yersinia pestis; LcrV protein; Monoclonal antibodies; Enzyme-linked immunosorbent assay; Plague; Pneumonia; virulence factors; Sputum ER - TY - JOUR T1 - Anger and depression in cocaine addiction: association with the orbitofrontal cortex. AN - 67427296; 15708297 AB - The high prevalence of anger, impulsivity and violence in cocaine addiction implicates chronic cocaine use in the compromise of higher-order inhibitory control neurocognitive processes. We used the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) anger content scale as a personality measure of inhibitory control and examined its association with glucose metabolism in the lateral orbitofrontal gyrus (LOFG) at rest as measured by positron emission tomography with 2-deoxy-2[(18)F]fluoro-D-glucose (PET (18)FDG) in 17 recently abstinent cocaine-dependent subjects and 16 comparison subjects. Three additional variables--the MMPI-2 depression content scale, metabolism in the medial orbitofrontal gyrus (MOFG) and the anterior cingulate (AC) gyrus--were inspected. When level of education was statistically controlled for, the LOFG was significantly associated with anger within the cocaine group. No other region was associated with anger within the cocaine-dependent group, and the LOFG did not correlate with depression within any of the study groups. The present study confirms earlier reports in demonstrating a positive association between relative metabolism at rest in the LOFG and cognitive-behavioral and personality measures of inhibitory control in drug addiction: the higher the metabolism, the better the inhibitory control. JF - Psychiatry research AU - Goldstein, Rita Z AU - Alia-Klein, Nelly AU - Leskovjan, Andreana C AU - Fowler, Joanna S AU - Wang, Gene-Jack AU - Gur, Ruben C AU - Hitzemann, Robert AU - Volkow, Nora D AD - Medical Research, Brookhaven National Laboratory, Bldg. 490, 30 Bell Ave, Upton, NY, 11973-5000, USA. rgoldstein@bnl.gov Y1 - 2005/01/30/ PY - 2005 DA - 2005 Jan 30 SP - 13 EP - 22 VL - 138 IS - 1 SN - 0165-1781, 0165-1781 KW - Radiopharmaceuticals KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Severity of Illness Index KW - Cognition Disorders -- diagnosis KW - Cognition Disorders -- metabolism KW - Positron-Emission Tomography KW - Cognition Disorders -- epidemiology KW - Mental Disorders -- epidemiology KW - Glucose -- metabolism KW - Gyrus Cinguli -- diagnostic imaging KW - Humans KW - Personality Disorders -- metabolism KW - Disruptive, Impulse Control, and Conduct Disorders -- metabolism KW - Mental Disorders -- metabolism KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Personality Disorders -- epidemiology KW - Personality Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - MMPI KW - Adult KW - Gyrus Cinguli -- metabolism KW - Chronic Disease KW - Inhibition (Psychology) KW - Prefrontal Cortex -- diagnostic imaging KW - Prefrontal Cortex -- metabolism KW - Depression -- metabolism KW - Depression -- epidemiology KW - Cocaine-Related Disorders -- epidemiology KW - Cocaine-Related Disorders -- metabolism KW - Anger UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67427296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Anger+and+depression+in+cocaine+addiction%3A+association+with+the+orbitofrontal+cortex.&rft.au=Goldstein%2C+Rita+Z%3BAlia-Klein%2C+Nelly%3BLeskovjan%2C+Andreana+C%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack%3BGur%2C+Ruben+C%3BHitzemann%2C+Robert%3BVolkow%2C+Nora+D&rft.aulast=Goldstein&rft.aufirst=Rita&rft.date=2005-01-30&rft.volume=138&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-26 N1 - Date created - 2005-02-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - PET imaging in clinical drug abuse research. AN - 68736070; 16250850 AB - Over the last two decades, SPECT (single photon emission computed tomography) and especially PET (positron emission tomography) have proven increasingly effective imaging modalities in the study of human psychopharmacology. Abusing populations can be studied at multiple times after abstinence begins, to give information about neurochemical and physiological adaptations of the brain during recovery from addiction. Individual human subjects can be studied using multiple positron labeled radiotracers, so as to probe more than one facet of brain function. PET and SPECT have been used to help our understanding of many aspects of the pharmacokinetics and pharmacodynamics of abused drugs, and have made valuable contributions in terms of drug mechanisms, drug interactions (e.g. cocaine and alcohol) and drug toxicities. They have also been employed to study the acute effects of drugs on populations of active drug abusers and of normal controls, and to evaluate the neurochemical consequences of candidate therapies for drug abuse. A particularly productive strategy has been the use of PET in conjunction with neuropsychological testing of subjects, to allow correlation of imaging data with uniquely human aspects of the effects of drugs, such as euphoria and craving. JF - Current pharmaceutical design AU - Gatley, S John AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Fowler, Joanna S AU - Logan, Jean AU - Ding, Yu-Shin AU - Gerasimov, Madina AD - Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973, USA. gatley@neu.edu Y1 - 2005 PY - 2005 DA - 2005 SP - 3203 EP - 3219 VL - 11 IS - 25 SN - 1381-6128, 1381-6128 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Morphine Dependence -- diagnostic imaging KW - Alcoholism -- diagnostic imaging KW - Tobacco Use Disorder -- diagnostic imaging KW - Nicotine -- metabolism KW - Humans KW - Cocaine-Related Disorders -- diagnostic imaging KW - Tomography, Emission-Computed, Single-Photon KW - Positron-Emission Tomography KW - Brain -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68736070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+design&rft.atitle=PET+imaging+in+clinical+drug+abuse+research.&rft.au=Gatley%2C+S+John%3BVolkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BFowler%2C+Joanna+S%3BLogan%2C+Jean%3BDing%2C+Yu-Shin%3BGerasimov%2C+Madina&rft.aulast=Gatley&rft.aufirst=S&rft.date=2005-01-01&rft.volume=11&rft.issue=25&rft.spage=3203&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+design&rft.issn=13816128&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-29 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - 241Am, 137Cs, Sr and Pb uptake by tobacco as influenced by application of Fe chelators to soil. AN - 67742545; 15829335 AB - To determine the potential for phytoextraction of 241Am and other contaminants from soil, accumulation of 241Am, 137Cs, Sr, Fe, Al, Pb, and Mg by tobacco was determined for soil applications of two concentrations of ethylenediaminetetraacetic acid (EDTA), citric acid, and ascorbic acid. In tobacco receiving EDTA at 3.1 mmol/kg of soil, 241Am content of plants averaged 15 Bq/kg (ranging up to 26 Bq/kg) while Fe concentrations became constant at 4.5 mmol/kg. Soil treatment with 18.8 mmol/kg EDTA resulted in average 241Am concentrations of 29 Bq/kg (19 times higher than controls). Uptake of Pb was similar to 241Am. In these samples, Fe increased to a maximum of almost 18 mmol/kg and 241Am content increased linearly with both Fe and Al. Plants receiving ascorbic and citric acids took up smaller quantities of 241Am, Pb, and Fe, even though these reagents were able to elute about as much Fe from the soil as EDTA. Synchrotron microbeam X-ray fluorescence (SXRF) was used to determine radial distributions of elements in roots and stems with and without EDTA treatment. SXRF maps indicate differences in behavior between Fe and Pb that are consistent with the bulk plant observations and provide insight into changes in metal content of the roots in the presence of EDTA. JF - Journal of environmental radioactivity AU - Fuhrmann, Mark AU - Lanzirotti, Antonio AD - Environmental Sciences Department, Brookhaven National Laboratory, Building 830, P.O. Box 5000, Upton, NY 11973, USA. fuhrmann@bnl.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 33 EP - 50 VL - 82 IS - 1 SN - 0265-931X, 0265-931X KW - Cesium Radioisotopes KW - 0 KW - Iron Chelating Agents KW - Metals, Heavy KW - Soil KW - Soil Pollutants KW - Soil Pollutants, Radioactive KW - Quartz KW - 14808-60-7 KW - Citric Acid KW - 2968PHW8QP KW - Edetic Acid KW - 9G34HU7RV0 KW - Iron KW - E1UOL152H7 KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Americium KW - VW92PHU2UY KW - Index Medicus KW - Citric Acid -- pharmacology KW - Cesium Radioisotopes -- analysis KW - Spectrometry, X-Ray Emission KW - Iron -- chemistry KW - Cesium Radioisotopes -- metabolism KW - Plant Stems -- chemistry KW - Plant Roots -- chemistry KW - Ascorbic Acid -- pharmacology KW - Iron -- metabolism KW - Edetic Acid -- pharmacology KW - Edetic Acid -- chemistry KW - Metals, Heavy -- metabolism KW - Tobacco -- drug effects KW - Tobacco -- chemistry KW - Soil Pollutants -- metabolism KW - Americium -- metabolism KW - Americium -- analysis KW - Tobacco -- metabolism KW - Iron Chelating Agents -- pharmacology KW - Soil Pollutants, Radioactive -- metabolism KW - Soil Pollutants, Radioactive -- analysis KW - Soil Pollutants -- analysis KW - Metals, Heavy -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67742545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+radioactivity&rft.atitle=241Am%2C+137Cs%2C+Sr+and+Pb+uptake+by+tobacco+as+influenced+by+application+of+Fe+chelators+to+soil.&rft.au=Fuhrmann%2C+Mark%3BLanzirotti%2C+Antonio&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2005-01-01&rft.volume=82&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+radioactivity&rft.issn=0265931X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-01 N1 - Date created - 2005-04-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Porphyrin-mediated boron neutron capture therapy: a preclinical evaluation of the response of the oral mucosa. AN - 67340483; 15606309 AB - Preclinical studies are in progress to determine the potential of boron neutron capture therapy (BNCT) for the treatment of carcinomas of the head and neck. Recently, it has been demonstrated that various boronated porphyrins can target a variety of tumor types. Of the porphyrins evaluated so far, copper tetracarboranylphenyl porphyrin (CuTCPH) is potentially a strong candidate for clinical use. In the present investigation, the response of the oral mucosa to CuTCPH-mediated boron neutron capture (BNC) irradiation was assessed using the ventral surface of the tongue of adult male Fischer 344 rats, a standard rodent model. CuTCPH was administered by intravenous infusion, at a dose of 200 mg/kg body weight, over a 48-h period. Three days after the end of the administration of CuTCPH, biodistribution studies indicated very low levels of boron (<2 microg/g) in the blood. Levels of boron in tongue tissue were 39.0 +/- 3.8 microg/g at this time. This was the time selected for irradiation with single doses of thermal neutrons from the Brookhaven Medical Research Reactor. The estimated level of boron-10 in the oral mucosa was used in the calculation of the physical radiation doses from the 10B(n,alpha)7Li reaction. This differs from the approach using the present generation of clinical boron carriers, where boron levels in blood at the time of irradiation are used for this calculation. Dose-response curves for the incidence of mucosal ulceration were fitted using probit analysis, and the doses required to produce a 50% incidence of the effect (ED50 +/- SE) were calculated. Analysis of the dose-effect data for CuTCPH-mediated BNC irradiation, compared with those for X rays and thermal neutrons alone, gave a compound biological effectiveness (CBE) factor of approximately 0.04. This very low CBE factor would suggest that there was relatively low accumulation of boron in the key target epithelial stem cells of the oral mucosa. As a consequence, with low levels of boron (<2 microg/g) in the blood, the response of the oral mucosa to CuTCPH-mediated BNCT will be governed primarily by the radiation effects of the thermal neutron beam and not from the boron neutron capture reaction [10B(n,alpha)7Li]. JF - Radiation research AU - Morris, G M AU - Coderre, J A AU - Micca, P L AU - Nawrocky, M M AU - Hopewell, J W AU - Miura, M AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 72 EP - 78 VL - 163 IS - 1 SN - 0033-7587, 0033-7587 KW - Metalloporphyrins KW - 0 KW - copper tetracarboranyltetraphenylporphyrin KW - Index Medicus KW - Space life sciences KW - Rats KW - Animals KW - Relative Biological Effectiveness KW - Rats, Inbred F344 KW - Radiotherapy Dosage KW - Body Burden KW - Treatment Outcome KW - Lethal Dose 50 KW - Tissue Distribution KW - Dose-Response Relationship, Radiation KW - Drug Evaluation, Preclinical KW - Female KW - Oral Ulcer -- pathology KW - Mouth Mucosa -- pathology KW - Boron Neutron Capture Therapy -- adverse effects KW - Mouth Mucosa -- radiation effects KW - Metalloporphyrins -- adverse effects KW - Metalloporphyrins -- therapeutic use KW - Boron Neutron Capture Therapy -- methods KW - Oral Ulcer -- etiology KW - Radiation Injuries -- pathology KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67340483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Porphyrin-mediated+boron+neutron+capture+therapy%3A+a+preclinical+evaluation+of+the+response+of+the+oral+mucosa.&rft.au=Morris%2C+G+M%3BCoderre%2C+J+A%3BMicca%2C+P+L%3BNawrocky%2C+M+M%3BHopewell%2C+J+W%3BMiura%2C+M&rft.aulast=Morris&rft.aufirst=G&rft.date=2005-01-01&rft.volume=163&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-08 N1 - Date created - 2004-12-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Variable-temperature structural studies of tetranatrolite from Mt. Saint-Hilaire; synchrotron X-ray powder diffraction and Rietveld analysis AN - 51734230; 2005-023546 AB - The temperature-dependent evolution of the crystal structure of natural tetranatrolite (Mt. Saint-Hilaire, approximate formula Na (sub 5.85) Ca (sub 1.90) Al (sub 9.25) Si (sub 10.75) O (sub 40) .11H (sub 2) O) was investigated using monochromatic synchrotron X-ray powder diffraction and Rietveld analysis. The room-temperature structural model reveals characteristic Al/Si and Na/Ca disordering over the framework tetrahedral and nonframework cation sites, respectively. Water molecules at the OW4 and OW5 sites along the elliptical channels surround the nonframework cations with full and partial occupancies, respectively, similar to what was observed in previous single crystal studies. As the temperature increases up to 300 degrees C, the partially occupied OW5 site is gradually dehydrated whereas the fully occupied OW4 site and the disordered Na/Ca site remain fully occupied. Upon complete dehydration of the OW5 site at 300 degrees C, another phase appears with approximately 1.8% expansion and approximately 6.7% reduction of the a- and c-axis parameters, respectively, leading to an overall volume reduction of approximately 3.3%. In this new phase, the Na and Ca atoms migrate to occupy two closely separated sites along the channels, and 80% of the OW4 water is lost with the remaining water molecules occupying a site close to the previously empty OW5 site. The material decomposes upon full dehydration near 400 degrees C and becomes X-ray amorphous. The temperature-dependent variations of the T-O-T angles and the chain rotation angle are indicative of the framework relaxation occurring during the selective dehydration and subsequent cation-water migration phase transition. JF - American Mineralogist AU - Lee, Yongjae AU - Hriljac, Joseph A AU - Vogt, Thomas Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 247 EP - 251 PB - Mineralogical Society of America, Washington, DC VL - 90 IS - 1 SN - 0003-004X, 0003-004X KW - silicates KW - X-ray diffraction data KW - Quebec KW - phase transitions KW - crystal structure KW - Rietveld refinement KW - natrolite KW - Mont-Saint-Hilaire Quebec KW - order-disorder KW - Canada KW - tetranatrolite KW - zeolite group KW - Rouville County Quebec KW - framework silicates KW - Eastern Canada KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51734230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Using+Lidar+to+Measure+Perfluorocarbon+Tracers+for+the+Verification+and+Monitoring+of+Cap+and+Cover+Systems&rft.au=Heiser%2C+John+H%3BSedlacek%2C+Arthur+J&rft.aulast=Heiser&rft.aufirst=John&rft.date=2006-02-01&rft.volume=170&rft.issue=1-4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/10.1007%2Fs11270-005-9007-8 L2 - http://www.minsocam.org/MSA/AmMin/TOC/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 20 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2014-03-14 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - Canada; crystal structure; Eastern Canada; framework silicates; Mont-Saint-Hilaire Quebec; natrolite; order-disorder; phase transitions; Quebec; Rietveld refinement; Rouville County Quebec; silicates; tetranatrolite; X-ray diffraction data; zeolite group DO - http://dx.doi.org/10.2138/am.2005.1696 ER - TY - JOUR T1 - Pressure-induced stabilization of ordered paranatrolite; a new insight into the paranatrolite controversy AN - 51733412; 2005-023547 AB - The origin and stability of paranatrolite (approximate formula Na (sub 16-x) Ca (sub x) Al (sub 16+x) Si (sub 24-x) O (sub 80) .4H (sub 2) O), a naturally occurring zeolite with the natrolite topology, has long been debated, with its detailed structure unknown. When taken from an aqueous environment and exposed to the atmosphere, paranatrolite is reported to irreversibly lose water and transform to gonnardite/tetranatrolite, Na (sub 16-x) Ca (sub x) Al (sub 16+x) Si (sub 24-x) O (sub 80) .nH (sub 2) O. Since the latter has a disordered Al/Si distribution over the framework tetrahedral sites, it is believed the same is true for paranatrolite. Natrolite itself (Na (sub 16) Al (sub 16) Si (sub 24) O (sub 80) .16H (sub 2) O) has Al/Si ordering, and as recently shown, undergoes a reversible volume expansion ( approximately 2.5%) due to pressure-induced hydration (PIH) above 1.2 GPa to a superhydrated phase (Na (sub 16) Al (sub 16) Si (sub 24) O (sub 80) .32H (sub 2) O). During this process, an intermediate phase with an even larger volume expansion of approximately 7.0% has been detected in a narrow pressure range near 1.0 GPa. We report here that this intermediate phase has a unit-cell compatible with the one reported for paranatrolite at ambient conditions with the same 24 water molecules per formula unit and propose that it is paranatrolite with an ordered Al/Si distribution. An unusual water-sodium chain is observed in the ordered paranatrolite structure: a sevenfold coordination of sodium cations provided by alternating two water bridges along the expanded elliptical channels. The density of the ordered paranatrolite is lower than those of the 16 and 32 water phases, with its channel openings far more circular than in the low-and high-pressure analogs. The atomistic details of the ordered paranatrolite provide a structural model for the naturally occurring paranatrolite and a complete understanding of this intriguing pressure-volume-hydration mechanism in natrolite, demonstrating the unique role of pressure in controlling the chemistry of microporous materials. JF - American Mineralogist AU - Lee, Yongjae AU - Hriljac, Joseph A AU - Parise, John B AU - Vogt, Thomas Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 252 EP - 257 PB - Mineralogical Society of America, Washington, DC VL - 90 IS - 1 SN - 0003-004X, 0003-004X KW - silicates KW - cell dimensions KW - experimental studies KW - pressure KW - stability KW - crystal structure KW - natrolite KW - order-disorder KW - laboratory studies KW - paranatrolite KW - zeolite group KW - framework silicates KW - crystal chemistry KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51733412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Pressure-induced+stabilization+of+ordered+paranatrolite%3B+a+new+insight+into+the+paranatrolite+controversy&rft.au=Lee%2C+Yongjae%3BHriljac%2C+Joseph+A%3BParise%2C+John+B%3BVogt%2C+Thomas&rft.aulast=Lee&rft.aufirst=Yongjae&rft.date=2005-01-01&rft.volume=90&rft.issue=1&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/10.2138%2Fam.2005.1588 L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 27 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - cell dimensions; crystal chemistry; crystal structure; experimental studies; framework silicates; laboratory studies; natrolite; order-disorder; paranatrolite; pressure; silicates; stability; zeolite group DO - http://dx.doi.org/10.2138/am.2005.1588 ER - TY - JOUR T1 - Molecular monitoring of SRB community structure and dynamics in batch experiments to examine the applicability of in situ precipitation of heavy metals for groundwater remediation AN - 51654473; 2006-001398 AB - Background, Aims and Scope. Sulfate-reducing bacteria (SRB) are known for their capacity to reduce and precipitate heavy metals (HM) as metal sulfides, offering the opportunity to create an in situ reactive zone for the treatment of heavy metal-contaminated groundwater, a process called in situ metal precipitation (ISMP). The applicability of the ISMP technology first has to be investigated at a laboratory scale before going into an on site application. The evaluation and optimization of the ISMP process is facilitated when physical/chemical analysis techniques are combined with molecular tools that specifically monitor the abundance, diversity and dynamics of the indigenous sulfate reducing microbial community. In this study, batch experiments were conducted in order to investigate the feasibility of ISMP as a groundwater remediation strategy for an industrial site contaminated with elevated levels of Zn, Cd, Co and Ni. Methods. The potential of different types of carbon source/electron donor (lactate, acetate, methanol, ethanol, Hydrogen Release Compound (super R) , molasses) to stimulate the sulfate reduction and metal precipitation activity of the naturally present (or indigenous) SRB community was explored. In addition, the effect of amending vitamin B12 and yeast extract was evaluated. The ISMP process was monitored by combining analytical analyzes of process parameters (SO (sub 4) (super 2-) -concentration, heavy metal concentrations, pH, E (sub h) ) with molecular tools such as SRB subgroup and genus specific PCR, denaturing gradient gel electrophoresis (DGGE), and phylogenetic analysis of clone sequences, based on either the 16S rRNA or the dsr (dissimilatory sulfite reductase) gene. Results and Discussion. The efficiency of different carbon-sources to stimulate the ISMP process followed the order HRC > molasses > methanol > lactate > ethanol > acetate. Within 10 weeks, the highest sulfate and metal removal efficiencies ranged from 85% to 99%. Addition of yeast extract boosted the ISMP process, whereas vitamin B12 negligibly affected SRB activity. Analysis of the sulfate reducing population by SRB subgroup and genus specific PCR demonstrated that members of the genus Desulfosporosinus dominated in all batch tests, while 16S rDNA DGGE profiles additionally revealed the presence in the microbial communities of non-sulfate reducing bacteria within the family Clostridium and the epsilon -proteobacteria. The dsrB-based DGGE profiles allowed us to assess the diversity and dynamics of the sulfate reducing community and added to a better understanding of the effects of different batch conditions on the ISMP process. Remarkably, all dsrB sequences affiliated with the dsrB gene sequence cluster found in Desulfotomaculum, which received their xenologous dsrB gene from the delta -proteobacteria. Conclusions. The batch experiments, which aimed at stimulating the activities of the indigenous SRB communities, demonstrated that these communities were present and that their activities could be used to obtain efficient in situ precipitation of the contaminating heavy metals. This opens the possibility to test this concept in the future as an on site demonstration as part of the groundwater strategy for the heavy metal contaminated site. Although batch setups are suitable for preliminary feasibility studies for ISMP, they do not reflect the in situ situation where sulfate and heavy metal and metalloid polluted groundwater are supplied continuously. A sulfate reducing strain JG32A was isolated from whose 16S rRNA gene affiliated with the genus Desulfosporosinus, while its dsrB gene sequence clustered with Desulfotomaculum dsrB gene sequences, which received their xenologous dsr genes from delta -proteobacteria. Therefore we hypothesize that the batch experiments enrich members of the Desulfosporosinus genus that possess a non-orthologous dsrB gene. Recommendation and Perspective. The next step towards an on site pilot test for ISMP will be the setup of a series of column experiments, with process conditions that are selected based on the above mentioned results. This will allow to define optimal ISMP process conditions and to test its long-term efficacy and sustainability before going into an on site bioremediation application. By applying the described molecular tools together with physical-chemical analyzes, it can be investigated whether the same SRB community is enriched and which type of C-source is most effective in promoting and sustaining its growth and sulfate-reduction activity. JF - Journal of Soils and Sediments AU - Geets, Joke AU - Borremans, Brigitte AU - Vangronsveld, Jaco AU - Diels, Ludo AU - van der Lelie, Daniel Y1 - 2005 PY - 2005 DA - 2005 SP - 149 EP - 163 PB - Ecomed Publishers, Landsberg VL - 5 IS - 3 SN - 1439-0108, 1439-0108 KW - experimental studies KW - monitoring KW - Western Europe KW - in situ KW - sulfates KW - pollutants KW - Kempen Belgium KW - pollution KW - Europe KW - bioremediation KW - remediation KW - ground water KW - aquifers KW - case studies KW - laboratory studies KW - precipitation KW - Belgium KW - bacteria KW - DNA KW - reduction KW - sulfides KW - heavy metals KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51654473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Soils+and+Sediments&rft.atitle=Molecular+monitoring+of+SRB+community+structure+and+dynamics+in+batch+experiments+to+examine+the+applicability+of+in+situ+precipitation+of+heavy+metals+for+groundwater+remediation&rft.au=Geets%2C+Joke%3BBorremans%2C+Brigitte%3BVangronsveld%2C+Jaco%3BDiels%2C+Ludo%3Bvan+der+Lelie%2C+Daniel&rft.aulast=Geets&rft.aufirst=Joke&rft.date=2005-01-01&rft.volume=5&rft.issue=3&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Journal+of+Soils+and+Sediments&rft.issn=14390108&rft_id=info:doi/10.1065%2Fjss2004.12.125 L2 - http://www.springerlink.com/(kugcki55vur4xmjtv2myls45)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:112850,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 37 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aquifers; bacteria; Belgium; bioremediation; case studies; DNA; Europe; experimental studies; ground water; heavy metals; in situ; Kempen Belgium; laboratory studies; monitoring; pollutants; pollution; precipitation; reduction; remediation; sulfates; sulfides; Western Europe DO - http://dx.doi.org/10.1065/jss2004.12.125 ER - TY - JOUR T1 - Basic considerations for Monte Carlo calculations in soil AN - 51512887; 2007-005308 JF - Applied Radiation and Isotopes AU - Hanson, Albert L AU - Song, Zhiguang AU - Orion, Itzhak AU - Hendrey, George Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 97 EP - 107 PB - Elsevier, Oxford VL - 62 IS - 1 SN - 0969-8043, 0969-8043 KW - soils KW - silicates KW - neutron methods KW - secondary minerals KW - moisture KW - Monte Carlo analysis KW - grain size KW - statistical analysis KW - data processing KW - weathering KW - porosity KW - physical properties KW - neutrons KW - gamma rays KW - sensitivity analysis KW - digital simulation KW - probability KW - chemical composition KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51512887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Radiation+and+Isotopes&rft.atitle=Basic+considerations+for+Monte+Carlo+calculations+in+soil&rft.au=Hanson%2C+Albert+L%3BSong%2C+Zhiguang%3BOrion%2C+Itzhak%3BHendrey%2C+George&rft.aulast=Hanson&rft.aufirst=Albert&rft.date=2005-01-01&rft.volume=62&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Applied+Radiation+and+Isotopes&rft.issn=09698043&rft_id=info:doi/10.1016%2Fj.apradiso.2004.06.003 L2 - http://www.sciencedirect.com/science/journal/09698043 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 24 N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - chemical composition; data processing; digital simulation; gamma rays; grain size; moisture; Monte Carlo analysis; neutron methods; neutrons; physical properties; porosity; probability; secondary minerals; sensitivity analysis; silicates; soils; statistical analysis; weathering DO - http://dx.doi.org/10.1016/j.apradiso.2004.06.003 ER - TY - JOUR T1 - Response to Newman: New uses of endophytic bacteria to improve phytoremediation AN - 20848101; 6185210 JF - Trends in Biotechnology AU - van der Lelie, D AU - Barac, T AU - Taghavi, S AU - Vangronsveld, J Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 8 EP - 9 VL - 23 IS - 1 SN - 0167-7799, 0167-7799 KW - Pollution Abstracts; Biotechnology and Bioengineering Abstracts KW - Phytoremediation KW - Endophytes KW - Reviews KW - phytoremediation KW - Biotechnology KW - W 30950:Waste Treatment & Pollution Clean-up KW - P 5000:LAND POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20848101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Biotechnology&rft.atitle=Response+to+Newman%3A+New+uses+of+endophytic+bacteria+to+improve+phytoremediation&rft.au=van+der+Lelie%2C+D%3BBarac%2C+T%3BTaghavi%2C+S%3BVangronsveld%2C+J&rft.aulast=van+der+Lelie&rft.aufirst=D&rft.date=2005-01-01&rft.volume=23&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Trends+in+Biotechnology&rft.issn=01677799&rft_id=info:doi/10.1016%2Fj.tibtech.2004.11.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Endophytes; Reviews; phytoremediation; Phytoremediation; Biotechnology DO - http://dx.doi.org/10.1016/j.tibtech.2004.11.008 ER - TY - JOUR T1 - Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin AN - 19930525; 6463438 AB - Clostridial neurotoxins are comprised of botulinum (BoNT) and tetanus (TeNT), which share significant structural and functional similarity. Crystal structures of the binding domain of TeNT complexed with disialyllactose (DiSia) and a tri-peptide Tyr-Glu-Trp (YEW) have been determined to 2.3 and 2.2 Aa, respectively. Both DiSia and YEW bind in a shallow cleft region on the surface of the molecule in the beta -trefoil domain, interacting with a set of common residues, Asp1147, Asp1214, Asn1216, and Arg1226. DiSia and YEW binding at the same site in tetanus toxin provides a putative site that could be occupied either by a ganglioside moiety or a peptide. Soaking experiments with a mixture of YEW and DiSia show that YEW competes with DiSia, suggesting that YEW can be used to block ganglioside binding. A comparison with the TeNT binding domain in complex with small molecules, BoNT/A and /B, provides insight into the different modes of ganglioside binding. Proteins 2005. Published 2005 Wiley-Liss, Inc. JF - Proteins: Structure, Function & Bioinformatics AU - Jayaraman, Seetharaman AU - Eswaramoorthy, Subramaniam AU - Kumaran, Desigan AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York, swami@bnl.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 288 EP - 295 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 61 IS - 2 SN - 0887-3585, 0887-3585 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - tetanus neurotoxin KW - GD3 KW - ganglioside KW - X-ray crystallography KW - [beta]-trefoil KW - inhibitors KW - Protein structure KW - Structure-function relationships KW - Crystal structure KW - Gangliosides KW - tetanus toxin KW - Bioinformatics KW - Neurotoxins KW - Tetanus KW - N3 11007:Neurobiology KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19930525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.atitle=Common+binding+site+for+disialyllactose+and+tri-peptide+in+C-fragment+of+tetanus+neurotoxin&rft.au=Jayaraman%2C+Seetharaman%3BEswaramoorthy%2C+Subramaniam%3BKumaran%2C+Desigan%3BSwaminathan%2C+Subramanyam&rft.aulast=Jayaraman&rft.aufirst=Seetharaman&rft.date=2005-01-01&rft.volume=61&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.20595 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein structure; Structure-function relationships; Crystal structure; Bioinformatics; tetanus toxin; Gangliosides; Tetanus; Neurotoxins DO - http://dx.doi.org/10.1002/prot.20595 ER - TY - JOUR T1 - Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region AN - 19671830; 7436469 AB - The development of positron emission tomography (PET) ligands for the norepinephrine transporter (NET) has been slow compared to the development of radiotracers for others systems, such as the dopamine (DAT) or the serotonin transporters (SERT). The main reason for this appears to be the high nonspecific (non-NET) binding exhibited by many of these tracers, which makes the identification of a reference region difficult. With other PET ligands the use of a reference region increases the reproducibility of the outcome measure in test/retest studies. The focus of this work is to identify a suitable reference region or means of normalizing data for the NET ligands investigated. Methods: We have analyzed the results of PET studies in the baboon brain with labeled reboxetine derivatives (S, S)-[ super(11)C]O-methyl reboxetine (SS-MRB), (S, S)-[ super(18)F]fluororeboxetine (SS-FRB) as well as O-[ super(11)C]nisoxetine and N-[ super(11)C]nisoxetme (NIS), and, for comparison, the less active (R, R) enantiomers (RR-MRB, RR-FRB) in terms of the distribution volume (DV) using measured arterial input functions. Results: (1) For a given subject, a large variation in DV for successive baseline studies was observed in regions with both high and low NET density. (2) The occipital cortex and the basal ganglia were found to be the regions with the smallest change between baseline (SS-MRB) and pretreatment with cocaine, and were therefore used as a composite reference region for calculation of a distribution volume ratio (DVR). (3) The variability [as measured by the coefficient of variation (CV)=standard deviation/mean] in the distribution volume ratio (DVR) of thalamus (to reference region) was considerably reduced over that of the DV using this composite reference region. (4) Pretreatment with nisoxetine (1.0 mg/kg 10 min prior to tracer) in one study produced (in decreasing order) reductions in thalamus, cerebellum, cingulate and frontal cortex consistent with known NET densities. (5) [ super(11)C]Nisoxetine had a higher background non-NET binding (DV) than the other tracers reported here with basal ganglia (a non-NET region) higher than thalamus. Conclusions: The reboxetine derivatives show a lot of promise as tracers for human PET studies of the norepinephrine system. We have identified a strategy for normalizing DVs to a reference region with the understanding that the DVR for these tracers may not be related to the binding potential in the same way as, for example, for the dopamine tracers, since the non-NET binding may differ between the target and nontarget regions. From our baboon studies the average DVR for thalamus (n = 18) for SS-MRB is 1.8; however, the lower limit is most likely less than 1 due to this difference in non-NET binding. JF - Nuclear Medicine and Biology AU - Logan, J AU - Ding, Y-S AU - Lin, K-S AU - Pareto, D AU - Fowler, J AU - Biegon, A AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA, logan@bnl.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 531 EP - 542 VL - 32 IS - 5 SN - 0969-8051, 0969-8051 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Cerebellum KW - reboxetine KW - Thalamus KW - Tracers KW - Baseline studies KW - Dopamine transporter KW - Dopamine KW - Norepinephrine transporter KW - Positron emission tomography KW - Cocaine KW - Papio KW - Cortex (occipital) KW - Brain KW - Cortex (frontal) KW - Cortex (cingulate) KW - Enantiomers KW - Norepinephrine KW - Serotonin transporter KW - Basal ganglia KW - W 30950:Waste Treatment & Pollution Clean-up KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19671830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dizhixue+Bao+%3D+Acta+Geologica+Sinica&rft.atitle=The+relationship+between+Cambrian-Ordovician+high-TOC+source+rock+development+and+paleoenvironment+variations+in+the+Tarim+Basin%2C+western+China%3B+carbon+and+oxygen+isotope+evidence&rft.au=Zhang%2C+Shuichang%3BWang%2C+Ruiliang%3BJin%2C+Zhijun%3BZhang%2C+Baomin%3BWang%2C+Darui%3BBian%2C+Lizeng&rft.aulast=Zhang&rft.aufirst=Shuichang&rft.date=2006-03-01&rft.volume=80&rft.issue=3&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Dizhixue+Bao+%3D+Acta+Geologica+Sinica&rft.issn=00015717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Papio; Positron emission tomography; Tracers; Thalamus; reboxetine; Serotonin transporter; Basal ganglia; Dopamine transporter; Norepinephrine transporter; Cerebellum; Cocaine; Dopamine; Enantiomers; Baseline studies; Cortex (cingulate); Cortex (frontal); Cortex (occipital); Brain; Norepinephrine DO - http://dx.doi.org/10.1016/j.nucmedbio.2005.04.005 ER - TY - JOUR T1 - fMRI-acoustic noise alters brain activation during working memory tasks AN - 19450387; 6965399 AB - Scanner noise during functional magnetic resonance imaging (fMRI) may interfere with brain function and change blood oxygenation level dependent (BOLD) signals, a problem that generally worsens at the higher field strengths. Therefore, we studied the effect of increased acoustic noise on fMRI during verbal working memory (WM) processing. The sound pressure level of scanner noise was increased by 12 dBA from "Quiet" to "Loud" echo planar imaging (EPI) scans by utilizing resonant vibration modes of the gradient coil. A WM paradigm with graded levels of task difficulty was used to further access WM load. Increased scanner noise produced increased BOLD responses (percent signal change) bilaterally in the cerebellum, inferior (IFG), medial (medFG), and superior (SFG) frontal, fusiform (FusG), and the lingual (LG) gyri, and decreased BOLD responses bilaterally in the anterior cingulate gyrus (ACG) and the putamen. This finding suggests greater recruitment of attention resources in these brain regions, probably to compensate for interference due to louder scanner noise. Increased working memory load increased the BOLD signals in IFG and the cerebellum, but decreased the BOLD signals in the putamen and the LG. These findings also support the idea that brain function requires additional attention resources under noisier conditions. Load- and acoustic-noise-related changes in BOLD responses correlated negatively in the WM network. This study demonstrates that MR noise affects brain activation pattern. Future comparisons between studies performed under different acoustic conditions (due to differing magnetic field strengths, pulse sequences, or scanner manufacturers) might require knowledge of the sound pressure level of acoustic noise during fMRI. JF - NeuroImage AU - Tomasi, D AU - Caparelli, E C AU - Chang, L AU - Ernst, T AD - Medical Department, Bldg. 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA, tomasi@bnl.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 377 EP - 386 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 27 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Cerebellum KW - Short term memory KW - Putamen KW - Sound KW - Pressure KW - Acoustics KW - Recruitment KW - Brain KW - Vibrations KW - Magnetic fields KW - Language KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19450387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=fMRI-acoustic+noise+alters+brain+activation+during+working+memory+tasks&rft.au=Tomasi%2C+D%3BCaparelli%2C+E+C%3BChang%2C+L%3BErnst%2C+T&rft.aulast=Tomasi&rft.aufirst=D&rft.date=2005-01-01&rft.volume=27&rft.issue=2&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.04.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Brain; Functional magnetic resonance imaging; Short term memory; Acoustics; Putamen; Sound; Cerebellum; Pressure; Vibrations; Language; Magnetic fields; Neuroimaging; Recruitment DO - http://dx.doi.org/10.1016/j.neuroimage.2005.04.010 ER - TY - JOUR T1 - A comparative study of ozone production in five U.S. metropolitan areas AN - 19428843; 6133558 AB - We present observations of O sub(3) and O sub(3) precursors measured at mid boundary layer altitude during field campaigns in Nashville, Tennessee (1995), New York City, New York (1996), Phoenix, Arizona (1998), Philadelphia, Pennsylvania (1999), and Houston, Texas (2000). Ozone production rates P(O sub(3)) and their sensitivity to NO sub( x ) and volatile organic carbons (VOCs) are calculated using observed concentrations as inputs to a steady state box model. City to city comparisons are made to illustrate common features of urban photochemistry and features that are unique to specific cities. Ozone production rates vary from nearly zero to 155 ppb h super(-1). Differences in P(O sub(3)) depend on precursor concentrations, namely, radical sources, NO sub( x ) and VOCs. Under conditions where P(O sub(3)) is greater than 25 ppb h super(-1), there is a potential to produce enough same-day O sub(3) to transform a typical regional background into a severe O sub(3) episode. Six such cases were observed, in Nashville, Philadelphia, and Houston, with elevated O sub(3) concentrations in the afternoon (130-211 ppb) following a morning in which P(O sub(3)) was 25-140 ppb h super(-1). High P(O sub(3)) occurs when NO sub( x ) concentrations are 5-25 ppb and OH-VOC reactivity is above 5 s super(-1). These conditions are infrequent, and aside from a common dependence on calm winds, reasons vary from city to city. In Nashville, high P(O sub(3)) was observed during a stagnation event over downtown and under the circumstance that an air mass with a high concentration of isoprene encountered a NO sub( x ) source. In Houston, NO sub( x ) and light olefins are coemitted from petrochemical facilities leading to the highest P(O sub(3))s of the five cities studied. High values of P(O sub(3)) did not occur in Phoenix because of low radical production, caused mainly by a dry atmosphere, and a low VOC to NO sub( x ) ratio. The sensitivity of P(O sub(3)) to its precursors varied from NO sub( x ) limited in rural samples to VOC limited near emission sources. In Philadelphia, and especially Phoenix, the highest O sub(3) production rates occurred under VOC-limited conditions. In Nashville, New York City, and Houston the high-P(O sub(3)) samples were near the ridge line where P(O sub(3)) responds somewhat to VOC reductions but is insensitive to NO sub( x ) changes. JF - Journal of Geophysical Research. D. Atmospheres AU - Kleinman, LI AU - Daum, PH AU - Lee, Y-N AU - Nunnermacker, L J AU - Springston AU - Weinstein-Lloyd, J AU - Rudolph, J AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York, USA Y1 - 2005/01// PY - 2005 DA - Jan 2005 PB - American Geophysical Union, 2000 Florida Ave., N.W. Washington DC 20009 USA, [mailto:service@agu.org], [URL:http://www.agu.org] VL - 110 IS - D2 SN - 0148-0227, 0148-0227 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Citation No. D02301 KW - photochemistry KW - ozone production rate KW - ozone precursors KW - 0365 Atmospheric Composition and Structure: Troposphere: composition and chemistry KW - 0345 Atmospheric Composition and Structure: Pollution: urban and regional (0305, 0478, 4251) KW - 0317 Atmospheric Composition and Structure: Chemical kinetic and photochemical properties. KW - Photochemistry KW - Photochemistry of atmospheric pollution KW - USA, Pennsylvania, Philadelphia KW - Air quality KW - USA, New York KW - Ozone-volatile organic compounds relationships KW - Air quality models KW - USA, New York, New York KW - USA, Tennessee KW - Ozone production KW - Ozone-nitrogen oxides relationships KW - Boundary layers KW - Ozone in urban air KW - USA, Pennsylvania KW - Atmospheric chemistry KW - USA, Arizona KW - USA, Texas, Houston KW - Volatile organic compounds KW - USA, Arizona, Phoenix KW - USA, Tennessee, Nashville KW - Urban areas KW - Ozone KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19428843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.atitle=A+comparative+study+of+ozone+production+in+five+U.S.+metropolitan+areas&rft.au=Kleinman%2C+LI%3BDaum%2C+PH%3BLee%2C+Y-N%3BNunnermacker%2C+L+J%3BSpringston%3BWeinstein-Lloyd%2C+J%3BRudolph%2C+J&rft.aulast=Kleinman&rft.aufirst=LI&rft.date=2005-01-01&rft.volume=110&rft.issue=D2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.issn=01480227&rft_id=info:doi/10.1029%2F2004JD005096 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-03-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Ozone-nitrogen oxides relationships; Ozone production; Photochemistry of atmospheric pollution; Ozone in urban air; Air quality models; Ozone-volatile organic compounds relationships; Photochemistry; Boundary layers; Atmospheric chemistry; Air quality; Volatile organic compounds; Ozone; Urban areas; USA, New York, New York; USA, Tennessee; USA, Pennsylvania, Philadelphia; USA, Pennsylvania; USA, Arizona; USA, Texas, Houston; USA, Tennessee, Nashville; USA, New York; USA, Arizona, Phoenix DO - http://dx.doi.org/10.1029/2004JD005096 ER - TY - JOUR T1 - Linking enzyme sequence to function using conserved property difference AN - 19421049; 6644031 AB - Families of homologous enzymes evolved from common progenitors. The JF - BMC Bioinformatics AU - Mayer, Kimberly M AU - McCorkle, Sean R AU - Shanklin, John AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 2005 PY - 2005 DA - 2005 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 6 IS - 1 SN - 1471-2105, 1471-2105 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 284 KW - Stem cells KW - Conserved sequence KW - Enzymes KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19421049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Linking+enzyme+sequence+to+function+using+conserved+property+difference&rft.au=Mayer%2C+Kimberly+M%3BMcCorkle%2C+Sean+R%3BShanklin%2C+John&rft.aulast=Mayer&rft.aufirst=Kimberly&rft.date=2005-01-01&rft.volume=6&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-6-284 L2 - http://www.biomedcentral.com/1471-2105/6/284 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Enzymes; Conserved sequence; Bioinformatics; Stem cells DO - http://dx.doi.org/10.1186/1471-2105-6-284 ER - TY - JOUR T1 - The dependence of tropospheric ozone production rate on ozone precursors AN - 16188727; 6137043 AB - An analytic formula is derived expressing the tropospheric O sub(3) production rate, P(O sub(3)), as a power law function of radical production rate, NO sub(x) concentration, and VOC-OH reactivity. Power law exponents depend on a single parameter, L sub(N)/Q, which is the fraction of free radicals removed by reactions with NO sub(x). The formula reproduces the functional form of P(O sub(3)) obtained from photochemical box model calculations. Ozone production rates are shown to have a smooth transition between previously derived low and high NO sub(x) limits. Potential applications of this formula include analysis of day to day and place to place variations in P(O sub(3)), with P(O sub(3)) either obtained from measurements collected during field campaigns or produced as output from chemical-transport models. JF - Atmospheric Environment AU - Kleinman, LI AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 575 EP - 586 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 39 IS - 3 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Ozone production rate KW - Tropospheric photochemistry KW - Ozone sensitivity KW - Low and high NO sub(x) KW - Ozone precursors KW - Troposphere KW - Nitrogen oxides KW - Tropospheric chemistry KW - Ozone in troposphere KW - Ozone production KW - Photochemicals KW - Chemical reactions KW - Atmospheric chemistry KW - Nitrogen oxides in troposphere KW - Photochemical models KW - Volatile organic compounds KW - Ozone KW - P 0000:AIR POLLUTION KW - M2 551.510.3/.4:Physical Properties/Composition (551.510.3/.4) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16188727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Structure+of+the+Mycobacterium+tuberculosis+proteasome+and+mechanism+of+inhibition+by+a+peptidyl+boronate&rft.au=Hu%2C+Guiqing%3BLin%2C+Gang%3BWang%2C+Ming%3BDick%2C+Lawrence%3BXu%2C+Rui-Ming%3BNathan%2C+Carl%3BLi%2C+Huilin&rft.aulast=Hu&rft.aufirst=Guiqing&rft.date=2006-03-01&rft.volume=59&rft.issue=5&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.05036.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-04-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Ozone in troposphere; Ozone production; Nitrogen oxides in troposphere; Photochemical models; Ozone; Tropospheric chemistry; Photochemicals; Chemical reactions; Atmospheric chemistry; Troposphere; Nitrogen oxides; Volatile organic compounds DO - http://dx.doi.org/10.1016/j.atmosenv.2004.08.047 ER - TY - JOUR T1 - Residential radon exposure and lung cancer risk: commentary on Cohen's county-based study. AN - 67070905; 15545771 AB - The large United States county-based study () in which an inverse relationship has been suggested between residential low-dose radon levels and lung cancer mortality has been reviewed. While this study has been used to evaluate the validity of the linear nonthreshold theory, the grouped nature of its data limits the usefulness of this application. Our assessment of the study's approach, including a reanalysis of its data, also indicates that the likelihood of strong, undetected confounding effects by cigarette smoking, coupled with approximations of data values and uncertainties in accuracy of data sources regarding levels of radon exposure and intensity of smoking, compromises the study's analytic power. The most clear data for estimating lung cancer risk from low levels of radon exposure continue to rest with higher-dose studies of miner populations in which projections to zero dose are consistent with estimates arising from most case-control studies regarding residential exposure. JF - Health physics AU - Heath, C W AU - Bond, P D AU - Hoel, D G AU - Meinhold, C B AD - Physics Department, Brookhaven National Laboratory, Upton, NY, USA. Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 647 EP - 55; discussion 656-8 VL - 87 IS - 6 SN - 0017-9078, 0017-9078 KW - Radon KW - Q74S4N8N1G KW - Index Medicus KW - Space life sciences KW - Non-programmatic KW - Risk KW - Humans KW - Smoking -- adverse effects KW - Male KW - Female KW - Lung Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- etiology KW - Radon -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67070905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Residential+radon+exposure+and+lung+cancer+risk%3A+commentary+on+Cohen%27s+county-based+study.&rft.au=Heath%2C+C+W%3BBond%2C+P+D%3BHoel%2C+D+G%3BMeinhold%2C+C+B&rft.aulast=Heath&rft.aufirst=C&rft.date=2004-12-01&rft.volume=440&rft.issue=7081&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature04593 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-09 N1 - Date created - 2004-11-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Adsorption of rare earth elements by gamma -Al (sub 2) O (sub 3) and Pseudomonas fluorescens cells in the presence of desferrioxamine B; implication of siderophores for the Ce anomaly AN - 51736400; 2005-026370 AB - We investigated the influence of siderophore desferrioxamine B (DFO) on the adsorption behavior of 11 rare-earth elements (REEs), La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, and Er, on gamma -Al (sub 2) O (sub 3) and Pseudomonas fluorescens cells at neutral pH. In the presence of DFO, the adsorption of REEs on gamma -Al (sub 2) O (sub 3) and P. fluorescens cells showed a tendency to decrease with an increase of their atomic number, except for Ce. The adsorption of Ce was significantly lower than those of the neighboring REEs, La and Pr. X-ray absorption near edge structure (XANES) analysis of the Ce-DFO complex showed that Ce was in the tetravalent state. Adding hydroxylammonium reduced the tetravalent Ce in the complex to its trivalent form with the disappearance of the Ce anomaly. These results show that DFO can oxidize Ce(III) to Ce(IV), which was supported by electrochemical experiments. Cyclic voltammetry (CV) revealed that the redox potential of the Ce(IV)/Ce(III) couple in the DFO complex was much lower than the standard redox potential, and that the stability of Ce(IV)-DFO is much higher than that of Ce(III)-DFO. These findings suggest that the Ce anomaly we observed is due to the oxidation of Ce(III)-DFO complex to the more stable Ce(IV)-DFO complex, and that naturally occurring organic ligands can contribute to Ce anomaly observed in the natural environment. JF - Chemical Geology AU - Yoshida, Takahiro AU - Ozaki, Takuo AU - Ohnuki, Toshihiko AU - Francis, Arokiasamy J A2 - Fortin, Danielle A2 - Takahashi, Yoshio A2 - Feriis, F. Grant Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 239 EP - 246 PB - Elsevier, Amsterdam VL - 212 IS - 3-4 SN - 0009-2541, 0009-2541 KW - mass spectra KW - Pseudomonas KW - electrochemical properties KW - remediation KW - cerium KW - XANES spectra KW - siderophores KW - aluminum oxides KW - oxides KW - valency KW - spectra KW - rare earths KW - trace elements KW - Eh KW - voltammetry KW - pollution KW - anomalies KW - adsorption KW - bioremediation KW - X-ray spectra KW - ICP mass spectra KW - desferrioxamine B KW - metals KW - bacteria KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51736400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Geology&rft.atitle=Adsorption+of+rare+earth+elements+by+gamma+-Al+%28sub+2%29+O+%28sub+3%29+and+Pseudomonas+fluorescens+cells+in+the+presence+of+desferrioxamine+B%3B+implication+of+siderophores+for+the+Ce+anomaly&rft.au=Yoshida%2C+Takahiro%3BOzaki%2C+Takuo%3BOhnuki%2C+Toshihiko%3BFrancis%2C+Arokiasamy+J&rft.aulast=Yoshida&rft.aufirst=Takahiro&rft.date=2004-12-01&rft.volume=212&rft.issue=3-4&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Chemical+Geology&rft.issn=00092541&rft_id=info:doi/10.1016%2Fj.chemgeo.2004.08.046 L2 - http://www.sciencedirect.com/science/journal/00092541 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 37 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - CHGEAD N1 - SubjectsTermNotLitGenreText - adsorption; aluminum oxides; anomalies; bacteria; bioremediation; cerium; desferrioxamine B; Eh; electrochemical properties; ICP mass spectra; mass spectra; metals; oxides; pollution; Pseudomonas; rare earths; remediation; siderophores; spectra; trace elements; valency; voltammetry; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.1016/j.chemgeo.2004.08.046 ER - TY - JOUR T1 - Mechanisms of arsenic immobilization in a biomat from mine discharge water AN - 51731816; 2005-026374 AB - We studied the mechanism of uptake of arsenic (As) in a bacterial microhabitat, a biomat, from discharged arsenic mine water at pH 4.7 in field and laboratory experiments. The mine water contained a yellowish biomat composed mainly of Fe-bearing compounds and associated microorganisms. Concentrations of As and Fe in the water decreased with increasing distance from the location of the discharge position. The spatial distributions of elements in the biomat collected at 0.3 m downstream from the discharge position, determined by scanning-particle-induced X-ray emission analysis (S-PIXE), indicated that As was co-located with Fe and S in the precipitates. Analyses of the precipitates by X-ray diffraction pattern (XRD) and transmission electron microscopy (TEM) revealed the presence of Fe-S-bearing minerals, such as schwertmannite and an unknown one, having a d-spacing of 3.3 Aa. X-ray absorption near edge structure (XANES) analysis of the precipitates indicated that the oxidation states of As and Fe were V and III, respectively, whereas their corresponding oxidation states in the discharged mine water were V and II. After storing fresh mine water, collected 0.3 m downstream of the discharge position, for 17 days there was a decrease in As and Fe concentrations from 1.2X10 (super -6) and 1.8X10 (super -4) mol L (super -1) to 3.6X10 (super -7) and 2.0X10 (super -5) mol L (super -1) , respectively, with the concomitant formation of a yellowish precipitate. In contrast, in filter-sterilized (0.2 mu m) mine water there was no change in their concentrations. Molecular analysis, based on the 16S rDNA fragment extracted from the discharged mine water, indicated that Gallionella sp. was the predominant microorganism present. It is known to form stalk-like and sheath-like compounds that were distinguished in the precipitates by TEM observation. These results demonstrate that As(V) in the discharged mine water is co-precipitated with and/or adsorbed on Fe-S-bearing minerals in the biomat. JF - Chemical Geology AU - Ohnuki, Toshihiko AU - Sakamoto, Fuminori AU - Kozai, Naofumi AU - Ozaki, Takuo AU - Yoshida, Takahiro AU - Narumi, Issay AU - Wakai, Eiichi AU - Sakai, Takuro AU - Francis, Arokiasamy J A2 - Fortin, Danielle A2 - Takahashi, Yoshio A2 - Feriis, F. Grant Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 279 EP - 290 PB - Elsevier, Amsterdam VL - 212 IS - 3-4 SN - 0009-2541, 0009-2541 KW - Far East KW - X-ray diffraction data KW - Gallionella KW - mass spectra KW - PIXE spectra KW - iron KW - remediation KW - emission spectra KW - XANES spectra KW - spectra KW - discharge KW - chemical composition KW - Asia KW - geochemistry KW - pH KW - abandoned mines KW - mines KW - acid mine drainage KW - pollutants KW - Gumma Japan KW - arsenic KW - pollution KW - adsorption KW - bioremediation KW - hydrochemistry KW - X-ray spectra KW - TEM data KW - biota KW - ICP mass spectra KW - precipitation KW - metals KW - bacteria KW - mobilization KW - Honshu KW - Japan KW - 02B:Hydrochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51731816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Geology&rft.atitle=Mechanisms+of+arsenic+immobilization+in+a+biomat+from+mine+discharge+water&rft.au=Ohnuki%2C+Toshihiko%3BSakamoto%2C+Fuminori%3BKozai%2C+Naofumi%3BOzaki%2C+Takuo%3BYoshida%2C+Takahiro%3BNarumi%2C+Issay%3BWakai%2C+Eiichi%3BSakai%2C+Takuro%3BFrancis%2C+Arokiasamy+J&rft.aulast=Ohnuki&rft.aufirst=Toshihiko&rft.date=2004-12-01&rft.volume=212&rft.issue=3-4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Chemical+Geology&rft.issn=00092541&rft_id=info:doi/10.1016%2Fj.chemgeo.2004.08.018 L2 - http://www.sciencedirect.com/science/journal/00092541 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 43 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - CHGEAD N1 - SubjectsTermNotLitGenreText - abandoned mines; acid mine drainage; adsorption; arsenic; Asia; bacteria; bioremediation; biota; chemical composition; discharge; emission spectra; Far East; Gallionella; geochemistry; Gumma Japan; Honshu; hydrochemistry; ICP mass spectra; iron; Japan; mass spectra; metals; mines; mobilization; pH; PIXE spectra; pollutants; pollution; precipitation; remediation; spectra; TEM data; X-ray diffraction data; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.1016/j.chemgeo.2004.08.018 ER - TY - JOUR T1 - Carbon cycling in soil AN - 51707502; 2005-044453 AB - As yet, nobody knows what effects climate change will have on soil carbon reserves, or how those changes will affect the global carbon cycle. Soils are the primary terrestrial repository for carbon, so minor changes in the balance between belowground carbon storage and release could have major impacts on greenhouse gases. Soil fauna, roots, fungi, and microbes interact with mineral and organic matter to process soil carbon. Studies have been hampered by the difficulty of observing processes beneath the earth's surface, but advances in science and technology are improving our ability to understand belowground ecosystems. JF - Frontiers in Ecology and the Environment AU - Johnston, Carol A AU - Groffman, Peter AU - Breshears, David D AU - Cardon, Zoe G AU - Currie, William AU - Emanuel, William AU - Gaudinski, Julia AU - Jackson, Robert B AU - Lajtha, Kate AU - Nadelhoffer, Knute AU - Nelson, David, Jr AU - Post, W Marc AU - Retallack, Gregory AU - Wielopolski, Lucian Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 522 EP - 528 PB - Ecological Society of America, Washington, DC VL - 2 IS - 10 SN - 1540-9295, 1540-9295 KW - climatic controls KW - technology KW - data acquisition KW - data processing KW - aliphatic hydrocarbons KW - rhizosphere KW - ecosystems KW - vegetation KW - climate change KW - carbon dioxide KW - carbon KW - retention KW - ecology KW - greenhouse effect KW - soils KW - concentration KW - soil profiles KW - methane KW - bulk density KW - roots KW - nitrous oxide KW - agriculture KW - pollution KW - alkanes KW - measurement KW - geochemical cycle KW - habitat KW - carbon monoxide KW - organic compounds KW - hydrocarbons KW - carbon cycle KW - land use KW - instruments KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51707502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Ecology+and+the+Environment&rft.atitle=Carbon+cycling+in+soil&rft.au=Johnston%2C+Carol+A%3BGroffman%2C+Peter%3BBreshears%2C+David+D%3BCardon%2C+Zoe+G%3BCurrie%2C+William%3BEmanuel%2C+William%3BGaudinski%2C+Julia%3BJackson%2C+Robert+B%3BLajtha%2C+Kate%3BNadelhoffer%2C+Knute%3BNelson%2C+David%2C+Jr%3BPost%2C+W+Marc%3BRetallack%2C+Gregory%3BWielopolski%2C+Lucian&rft.aulast=Johnston&rft.aufirst=Carol&rft.date=2004-12-01&rft.volume=2&rft.issue=10&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Ecology+and+the+Environment&rft.issn=15409295&rft_id=info:doi/ L2 - http://www.frontiersinecology.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 39 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - agriculture; aliphatic hydrocarbons; alkanes; bulk density; carbon; carbon cycle; carbon dioxide; carbon monoxide; climate change; climatic controls; concentration; data acquisition; data processing; ecology; ecosystems; geochemical cycle; greenhouse effect; habitat; hydrocarbons; instruments; land use; measurement; methane; microorganisms; nitrous oxide; organic compounds; pollution; retention; rhizosphere; roots; soil profiles; soils; technology; vegetation ER - TY - JOUR T1 - Dosimetry and risk from low- versus high-LET radiation of Auger events and the role of nuclide carriers. AN - 67261019; 15764388 AB - PURPOSETo analyse the lethality to mammalian cells of (125)I-decays in DNA, in antipyrine in the whole cell and in oligodeoxynucleotides in the nucleus outside DNA as a function of Auger event-site and number.MATERIALS AND METHODSAuger events cause both low- and high-linear energy transfer energy depositions including charge neutralization at the daughter nuclide. Microdosimetry allows the expression of absorbed dose to a defined micromass and the number of such events at given sites. Published data were used to relate micromass dose and event number to the dose to reduce survival to 37% of the initial survival (D37).RESULTSThe D37 of (125)I-decays in DNA was 0.1 Gy in terms of absorbed dose to the cell nucleus and about 30 in terms of average decays per nucleus or whole cell. The D37 of (125)I-decays in antipyrine was 1.5 Gy for absorbed dose to the cell nucleus, about 250 in terms of average decays per nucleus and about 2 x 10(3) for average decays per whole cell. (125)I-decays in oligodeoxynucleotides were much less toxic than (125)I-decays in antipyrine by a factor of about 25 in terms of average absorbed dose to the cell nucleus, by a factor or about 40 in terms of average decays per cell nucleus and by a factor of six in terms of average decays per whole cell.CONCLUSIONThe unexpected low toxicity of (125)I-decays in nuclear oligodeoxynucleotides outside the DNA in comparison with (125)I-decays in antipyrine in the nucleus or the whole cell demands further attention on the role of oligodeoxynucleotides in altering cellular radiation sensitivity. JF - International journal of radiation biology AU - Feinendegen, L E AU - Neumann, R D AD - Brookhaven National Laboratory, Upton, NY, USA. PY - 2004 SP - 813 EP - 822 VL - 80 IS - 11-12 SN - 0955-3002, 0955-3002 KW - Iodine Radioisotopes KW - 0 KW - Oligonucleotides KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Animals KW - Electrons KW - Risk Factors KW - Humans KW - Apoptosis -- radiation effects KW - Dose-Response Relationship, Radiation KW - Cell Survival -- radiation effects KW - Cell Nucleus -- radiation effects KW - Cell Physiological Phenomena -- radiation effects KW - Iodine Radioisotopes -- adverse effects KW - Oligonucleotides -- radiation effects KW - Linear Energy Transfer -- physiology KW - Risk Assessment -- methods KW - Radiometry -- methods KW - Oligonucleotides -- metabolism KW - DNA -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67261019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.atitle=Improved+Representation+of+Cloud+Droplet+Activation+and+Autoconversion+and+their+Implications+for+Estimating+Aerosol+Indirect+Effects&rft.au=Liu%2C+Y%3BDaum%2C+P%3BMcgraw%2C+R%3BMiller%2C+M&rft.aulast=Liu&rft.aufirst=Y&rft.date=2006-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-06 N1 - Date created - 2005-03-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Decreased brain dopaminergic transporters in HIV-associated dementia patients. AN - 66984998; 15319273 AB - HIV has a propensity to invade subcortical regions of the brain, which may lead to a subcortical dementia termed HIV-cognitive motor complex. Therefore, we aimed to assess whether dopamine (DA) D2 receptors and transporters (DAT) are affected in the basal ganglia of subjects with HIV, and how these changes relate to dementia status. Fifteen HIV subjects (age 44.5 +/- 11 years; CD4 185 +/- 130/mm3)) and 13 seronegative controls (42 +/- 12 years) were evaluated with PET to assess availability of DAT ([11C]cocaine) and DA D2 receptor ([11C]raclopride). HIV patients with associated dementia (HAD), but not those without dementia (ND) had significantly lower DAT availability in putamen (-19.3%, P = 0.009) and ventral striatum (-13.6%, P = 0.03) compared with seronegative controls. Higher plasma viral load in the HIV dementia patients correlated with lower DAT in the caudate (r = -0.7, P = 0.02) and putamen (r = -0.69, P = 0.03). DA D2 receptor availability, however, showed mild and non-significant decreases in HIV patients. These results provide the first evidence of DA terminal injury in HIV dementia patients, and suggest that decreased DAT may contribute to the pathogenesis of HIV dementia. The greater DAT decrease in the putamen than in the caudate parallels that observed in Parkinson's disease. The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals. JF - Brain : a journal of neurology AU - Wang, Gene-Jack AU - Chang, Linda AU - Volkow, Nora D AU - Telang, Frank AU - Logan, Jean AU - Ernst, Thomas AU - Fowler, Joanna S AD - Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA. Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 2452 EP - 2458 VL - 127 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - RNA, Viral KW - Receptors, Dopamine D2 KW - SLC6A3 protein, human KW - Abridged Index Medicus KW - Index Medicus KW - Viral Load KW - Positron-Emission Tomography KW - Humans KW - Adult KW - HIV -- isolation & purification KW - Aged KW - Middle Aged KW - Male KW - Female KW - Receptors, Dopamine D2 -- metabolism KW - RNA, Viral -- blood KW - AIDS Dementia Complex -- diagnostic imaging KW - AIDS Dementia Complex -- metabolism KW - AIDS Dementia Complex -- virology KW - Nerve Tissue Proteins -- metabolism KW - Brain -- metabolism KW - Membrane Transport Proteins -- metabolism KW - Brain -- diagnostic imaging KW - Membrane Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66984998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%3A+a+journal+of+neurology&rft.atitle=Decreased+brain+dopaminergic+transporters+in+HIV-associated+dementia+patients.&rft.au=Wang%2C+Gene-Jack%3BChang%2C+Linda%3BVolkow%2C+Nora+D%3BTelang%2C+Frank%3BLogan%2C+Jean%3BErnst%2C+Thomas%3BFowler%2C+Joanna+S&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2004-11-01&rft.volume=127&rft.issue=&rft.spage=2452&rft.isbn=&rft.btitle=&rft.title=Brain+%3A+a+journal+of+neurology&rft.issn=1460-2156&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-18 N1 - Date created - 2004-10-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Pressure-induced stabilization of ordered paranatrolite; a possible solution to the paranatrolite controversy AN - 51692557; 2005-053573 AB - The origin and stability of paranatrolite (approximate formula Na (sub 16-x) Ca (sub x) Al (sub 16+x) Si (sub 24-x) O (sub 80) . 24H (sub 2) O), a naturally occurring zeolite with the natrolite topology, has long been debated, with its detailed structure unknown. When taken from an aqueous environment and exposed to the atmosphere, paranatrolite is reported to irreversibly lose water and transform to gonnardite/tetranatrolite, Na (sub 16-x) Ca (sub x) Al (sub 16+x) Si (sub 24-x) O (sub 80) . nH (sub 2) O. Since the latter has a disordered Al/Si distribution over the framework tetrahedral sites, it is believed the same is true for paranatrolite. Natrolite itself (Na (sub 16) Al (sub 16) Si (sub 24) O (sub 80) . 16H (sub 2) O) has Al/Si ordering, and as recently shown, undergoes a reversible volume expansion ( approximately 2.5%) due to pressure-induced hydration (PIH) above 1.2 GPa to a superhydrated phase (Na (sub 16) Al (sub 16) Si (sub 24) O (sub 80) . 32H (sub 2) O). During this process, an intermediate phase with an even larger volume expansion of approximately 7.0% has been detected in a narrow pressure range near 1.0 GPa. We report here that this intermediate phase has a unit cell compatible with the one reported for paranatrolite at ambient conditions with the same 24 water molecules per formula unit and propose that it is paranatrolite with an ordered Al/Si distribution. An unusual water-sodium chain is observed in the ordered paranatrolite: a seven-fold coordination of sodium cations provided by alternating two water bridges along the expanded elliptical channels. The density of the ordered paranatrolite is lower than those of the 16 and 32 water phases, with its channel openings far more circular than its low and high pressure analogs. The atomistic details of the ordered paranatrolite provide a structural model for the naturally occurring paranatrolite and a complete understanding of this intriguing pressure-volume-hydration mechanism in natrolite, demonstrating the unique role of pressure in controlling the chemistry of microporous materials. JF - Abstracts with Programs - Geological Society of America AU - Lee, Yongjae AU - Hriljac, Joseph A AU - Parise, John B AU - Vogt, Thomas AU - Anonymous Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 113 PB - Geological Society of America (GSA), Boulder, CO VL - 36 IS - 5 SN - 0016-7592, 0016-7592 KW - silicates KW - pressure KW - crystal structure KW - natrolite KW - order-disorder KW - hydration KW - controls KW - paranatrolite KW - zeolite group KW - topology KW - framework silicates KW - crystal chemistry KW - formula KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51692557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Pressure-induced+stabilization+of+ordered+paranatrolite%3B+a+possible+solution+to+the+paranatrolite+controversy&rft.au=Lee%2C+Yongjae%3BHriljac%2C+Joseph+A%3BParise%2C+John+B%3BVogt%2C+Thomas%3BAnonymous&rft.aulast=Lee&rft.aufirst=Yongjae&rft.date=2004-11-01&rft.volume=36&rft.issue=5&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2004 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2005-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - controls; crystal chemistry; crystal structure; formula; framework silicates; hydration; natrolite; order-disorder; paranatrolite; pressure; silicates; topology; zeolite group ER - TY - JOUR T1 - High-temperature synchrotron XRD studies of Zn/Mn-oxides; a comparison of dehydration mechanisms in chalcophanite and woodruffite AN - 51692336; 2005-053572 AB - Chalcophanite (ZnMn (sub 3) O (sub 7) . 3H (sub 2) O) and woodruffite (Zn (sub 0.7) Mn (sub 3.45) O (sub 7) . 2.4H (sub 2) O) form in oxidizing zones of Zn- and Mn-bearing deposits. Chalcophanite is constructed of sheets of Mn (super 4+) -O octahedra with Zn and H (sub 2) O between the layers. One of seven octahedral sites in the Mn-O sheet is vacant, and the Zn cations sit above and below the vacancies (Post and Appleman 1988). Among the birnessite-like layer Mn oxides, chalcophanite is unique in its tendency to form crystals suitable for detailed structural analysis, thereby providing special insight into this environmentally important mineral group. Post et al (2003) recently determined that the woodruffite structure consists of large tunnels that measure 3 and 4 octahedra on a side, the largest of any yet reported in natural or synthetic Mn oxides. The woodruffite structure may serve as a model for a new class of octahedral molecular sieves with enhanced capabilities as catalysts and selective cation-exchange agents. We have used in situ, temperature-resolved synchrotron powder X-ray diffraction to investigate the thermal stability and dehydration behaviors of chalcophanite and woodruffite. The data were collected at the National Synchrotron Light Source using an imaging plate. Samples of chalcophanite and woodruffite were each heated in glass capillaries in air from 26 to 800 degrees C. Our results revealed that as chalcophanite loses interlayer H (sub 2) O between approximately 175 and 200 degrees C, the interlayer spacing collapses from 7.3 to 4.8, forming the anhydrous phase ZnMn (sub 3) O (sub 7) . The interlayer Zn changes from octahedral coordination (to 3O and 3H (sub 2) O) in chalcophanite to tetrahedral coordination in the anhydrous phase. Above approximately 500 degrees C, the Mn-O distances increase and exhibit Jahn-Teller type distortions indicating reduction of some Mn (super 4+) to Mn (super 3+) on the octahedral sites. Also above approximately 500 degrees C, the anhydrous chalcophanite phase starts transforming into the Zn/Mn spinel, hetearolite [(Zn (sub .75) Mn (sub .25) )Mn (sub 2) O (sub 4) ]. By approximately 700 degrees C, this conversion is complete. Dehydration in woodruffite also leads to a spinel-like phase, but the reaction sequence is similar to that of todorokite, which has a 3X3 tunnel topology. The collapse of the woodruffite structure and loss of H (sub 2) O at approximately 300 degrees C is triggered by the loss of O atoms from the octahedral framework and the consequent reduction of Mn, followed by the appearance of a Zn/Mn spinel. JF - Abstracts with Programs - Geological Society of America AU - Post, Jeffrey E AU - Heaney, Peter J AU - Hanson, Jonathan C AU - Anonymous Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 112 EP - 113 PB - Geological Society of America (GSA), Boulder, CO VL - 36 IS - 5 SN - 0016-7592, 0016-7592 KW - X-ray data KW - manganese oxides KW - oxides KW - chalcophanite KW - dehydration KW - high temperature KW - zinc oxides KW - woodruffite KW - temperature KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51692336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=High-temperature+synchrotron+XRD+studies+of+Zn%2FMn-oxides%3B+a+comparison+of+dehydration+mechanisms+in+chalcophanite+and+woodruffite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+Peter+J%3BHanson%2C+Jonathan+C%3BAnonymous&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2004-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Conference+on+Hurricanes+and+Tropical+Meteorology&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2004 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2005-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - chalcophanite; dehydration; high temperature; manganese oxides; oxides; temperature; woodruffite; X-ray data; zinc oxides ER - TY - JOUR T1 - Uncertainty Requirements in Radiative Forcing of Climate Change AN - 20631402; 6248447 AB - The continuing increase in atmospheric carbon dioxide (CO2) makes it essential that climate sensitivity, the equilibrium change in global mean surface temperature that would result from a given radiative forcing, be quantified with known uncertainty. Present estimates are quite uncertain, 3 +- 1.5 K for doubling of CO2. Model studies examining climate response to forcing by greenhouse gases and aerosols exhibit large differences in sensitivities and imposed aerosol forcings that raise questions regarding claims of their having reproduced observed large-scale changes in surface temperature over the 20th century. Present uncertainty in forcing, caused largely by uncertainty in forcing by aerosols, precludes meaningful model evaluation by comparison with observed global temperature change or empirical determination of climate sensitivity. Uncertainty in aerosol forcing must be reduced at least three-fold for uncertainty in climate sensitivity to be meaningfully reduced and bounded. JF - Journal of the Air & Waste Management Association AU - Schwartz, SE AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, NY, USA Y1 - 2004/11// PY - 2004 DA - Nov 2004 VL - 54 IS - 11 SN - 1096-2247, 1096-2247 KW - radiative forcing KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Surface temperatures KW - Aerosols KW - Climate models KW - Climatic changes KW - Climate change KW - Temperature KW - Radiative forcing KW - Climate sensitivity KW - Global temperature changes KW - Atmospheric chemistry KW - Carbon dioxide KW - Atmospheric aerosols KW - Greenhouse gases KW - M2 551.583:Variations (551.583) KW - P 0000:AIR POLLUTION KW - M2 551.521.1/.18:Solar (551.521.1/.18) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20631402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Uncertainty+Requirements+in+Radiative+Forcing+of+Climate+Change&rft.au=Schwartz%2C+SE&rft.aulast=Schwartz&rft.aufirst=SE&rft.date=2004-11-01&rft.volume=54&rft.issue=11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-07-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Surface temperatures; Radiative forcing; Climate models; Global temperature changes; Climate sensitivity; Climate change; Greenhouse gases; Atmospheric aerosols; Carbon dioxide; Aerosols; Climatic changes; Atmospheric chemistry; Temperature ER - TY - JOUR T1 - Analysis of temperature and pressure changes in liquefied natural gas (LNG) cryogenic tanks AN - 20978940; 6074707 AB - Liquefied natural gas (LNG) is being developed as a transportation fuel for heavy vehicles such as trucks and transit buses, to lessen the dependency on oil and to reduce greenhouse gas emissions. The LNG stations are properly designed to prevent the venting of natural gas (NG) from LNG tanks, which can cause evaporative greenhouse gas emissions and result in fluctuations of fuel flow and changes of fuel composition. Boil-off is caused by the heat added into the LNG fuel during the storage and fueling. Heat can leak into the LNG fuel through the shell of tank during the storage and through hoses and dispensers during the fueling. Gas from tanks onboard vehicles, when returned to LNG tanks, can add additional heat into the LNG fuel. A thermodynamic and heat transfer model has been developed to analyze different mechanisms of heat leak into the LNG fuel. The evolving of properties and compositions of LNG fuel inside LNG tanks is simulated. The effect of a number of buses fueled each day on the possible total fuel loss rate has been analyzed. It is found that by increasing the number of buses, fueled each day, the total fuel loss rate can be reduced significantly. It is proposed that an electric generator be used to consume the boil-off gas or a liquefier be used to re-liquefy the boil-off gas to reduce the tank pressure and eliminate fuel losses. These approaches can prevent boil-off of natural gas emissions, and reduce the costs of LNG as transportation fuel. JF - Cryogenics AU - Chen, Q-S AU - Wegrzyn, J AU - Prasad, V AD - Institute of Mechanics, Chinese Academy of Sciences 15 Bei Si Huan Xi Road, Beijing 100080, China, jwegrzyn@bnl.gov Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 701 EP - 709 PB - Butterworth Scientific Ltd. VL - 44 IS - 10 SN - 0011-2275, 0011-2275 KW - Pollution Abstracts KW - Liquefied natural gas KW - Transportation fuel KW - Cryogenics KW - Thermodynamics KW - Heat transfer , Nomenclature KW - buses KW - Motor vehicles KW - Fuels KW - Temperature KW - Natural gas KW - Storage KW - Oil KW - Transportation KW - electric generators KW - Emissions KW - heat transfer KW - Trucks KW - Greenhouse gases KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20978940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cryogenics&rft.atitle=Analysis+of+temperature+and+pressure+changes+in+liquefied+natural+gas+%28LNG%29+cryogenic+tanks&rft.au=Chen%2C+Q-S%3BWegrzyn%2C+J%3BPrasad%2C+V&rft.aulast=Chen&rft.aufirst=Q-S&rft.date=2004-10-01&rft.volume=44&rft.issue=10&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Cryogenics&rft.issn=00112275&rft_id=info:doi/10.1016%2Fj.cryogenics.2004.03.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - buses; Thermodynamics; Fuels; Motor vehicles; Temperature; Natural gas; Oil; Storage; Liquefied natural gas; Transportation; electric generators; Emissions; heat transfer; Trucks; Greenhouse gases DO - http://dx.doi.org/10.1016/j.cryogenics.2004.03.020 ER - TY - JOUR T1 - Phasing in iodine for structure determination AN - 17701292; 6088819 AB - A new method for solving X-ray crystal structures relies on the introduction of iodine into proteins in the form of p-iodophenylalanine. JF - Nature Biotechnology AU - Dauter, Z AD - Synchrotron Radiation Research Section of the National Cancer Institute, Brookhaven National Laboratory Bldg 725A, Upton, NY 11973, USA, dauter@bnl.gov Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 1239 EP - 1240 VL - 22 IS - 10 SN - 1087-0156, 1087-0156 KW - p-iodophenylalanine KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Reviews KW - Crystal structure KW - Iodine KW - W2 32340:Other peptides, proteins, amino acids KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17701292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Phasing+in+iodine+for+structure+determination&rft.au=Dauter%2C+Z&rft.aulast=Dauter&rft.aufirst=Z&rft.date=2004-10-01&rft.volume=22&rft.issue=10&rft.spage=1239&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Reviews; Iodine; Crystal structure ER - TY - JOUR T1 - Oligomeric State of the Escherichia coli Metal Transporter YiiP AN - 17827475; 6029988 AB - YiiP is a 32.9-kDa metal transporter found in the plasma membrane of Escherichia coli (Chao, Y., and Fu, D. (2004) J. Biol. Chem. 279, 17173-17180). Here we report the determination of the YiiP oligomeric state in detergent-lipid micelles and in membranes. Molecular masses of YiiP solubilized with dodecyl-, undecyl-, decyl-, or nonyl-beta-D-maltoside were measured directly using size- exclusion chromatography coupled with laser light-scattering photometry, yielding a mass distribution of YiiP homo-oligomers within a narrow range (68.0- 68.8 kDa) that equals the predicted mass of a YiiP dimer within experimental error. The detergent-lipid masses associated with YiiP in the mixed micelles were found to increase from 135.5 to 232.6 kDa, with an apparent correlation with the alkyl chain length of the maltoside detergents. Cross-linking the detergent-solubilized YiiP with 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) resulted in a dimeric cross-linked product in an EDC concentration-dependent manner. The oligomeric state of the purified YiiP in reconstituted membranes was determined by electron microscopic analysis of two- dimensional YiiP crystals in negative stain. A projection structure calculated from measurable optical diffractions to 25 Aa revealed a pseudo-2-fold symmetry within a molecular boundary of -75 x 40 Aa, indicative of the presence of YiiP dimers in membranes. These data provide direct structural evidence for a dimeric association of YiiP both in detergent-lipid micelles and in the reconstituted lipid bilayer. The functional relevance of the dimeric association in YiiP is discussed. JF - Journal of Biological Chemistry AU - Wei, Yinan AU - Li, Huilin AU - Fu, Dax AD - Department of Biology, Brookhaven National Laboratory, Upton, New York Y1 - 2004/09/17/ PY - 2004 DA - 2004 Sep 17 SP - 39251 EP - 39259 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 279 IS - 38 SN - 0021-9258, 0021-9258 KW - YiiP protein KW - Microbiology Abstracts B: Bacteriology KW - Metals KW - Lipid bilayers KW - Chromatography KW - Detergents KW - carbodiimide KW - Crystals KW - Plasma membranes KW - Micelles KW - Photometry KW - Cross-linking KW - Escherichia coli KW - Lasers KW - Diffraction KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17827475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Oligomeric+State+of+the+Escherichia+coli+Metal+Transporter+YiiP&rft.au=Wei%2C+Yinan%3BLi%2C+Huilin%3BFu%2C+Dax&rft.aulast=Wei&rft.aufirst=Yinan&rft.date=2004-09-17&rft.volume=279&rft.issue=38&rft.spage=39251&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Metals; Lipid bilayers; Plasma membranes; Detergents; Cross-linking; Chromatography; Photometry; Micelles; carbodiimide; Lasers; Crystals; Diffraction; Escherichia coli ER - TY - JOUR T1 - Adsorption of trace metals on glass fiber filters. AN - 66859357; 15356258 AB - Filters, containing glass-fiber (GF) filter material, are commonly used as the primary filter or as the prefilter in sampling natural waters and laboratory experiments with high concentrations of suspended solids. We observed that GF filter material removed substantial quantities of trace metals from solutions of low ionic strength at near neutral and slightly acidic pH. The GF material sorbed essentially all Pb and Ag from 5-mL aliquots of solutions containing 0.054 and 0.093 mM, respectively. Somewhat less Ni was sorbed from a 0.099 mM solution. This material retained about 43 micromol of Ag per gram of GF material (4600 microg/g). The Ag and Ni sorption was highest at low KNO(3) concentrations (as background electrolyte) and decreased to a constant concentration of sorbed metal at approximately 10 mM KNO(3). Glass-fiber filter material should only be used with careful testing for the elements of concern under conditions that closely match expected environmental or experimental conditions. JF - Journal of environmental quality AU - Fuhrmann, Mark AU - Fitts, Jeffrey P AD - Environmental Sciences Department, Building 830, Brookhaven National Laboratory, Upton, NY 11973, USA. fuhrmann@bnl.gov PY - 2004 SP - 1943 EP - 1944 VL - 33 IS - 5 SN - 0047-2425, 0047-2425 KW - Metals KW - 0 KW - Water Pollutants KW - fiberglass KW - Index Medicus KW - Filtration KW - Adsorption KW - Glass KW - Water Purification -- methods KW - Metals -- isolation & purification KW - Water Pollutants -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66859357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+quality&rft.atitle=Adsorption+of+trace+metals+on+glass+fiber+filters.&rft.au=Fuhrmann%2C+Mark%3BFitts%2C+Jeffrey+P&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2004-09-01&rft.volume=33&rft.issue=5&rft.spage=1943&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-07 N1 - Date created - 2004-09-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - BOOK T1 - Lauriston S. Taylor Lecture: The evolution of radiation protection--from erythema to genetic risks to risks of cancer to...? AN - 66774128; 15303059 AB - Radiation Protection has evolved and will continue to evolve as new information becomes available, as the result of changes in public perception and concern and, perhaps in the future, as a result of enormous expenditures on reducing small risks. In the early part of the last century it was a sense of real danger among medical Practitioners that prompted the first set of exposure limiting suggestions. Addressing medical concerns continued to be the basis of guidance until after the Second World War. An array of new sources and applications led to new approaches, which modified many of the technical issues but didn't result in substantial changes in the dose limits. Fallout from the first generation of thermonuclear weapons in the 1950's resulted in focusing attention on genetic effects, which continued until the middle 1970's. Data from the Japanese Survivor Studies provided the information for risk based recommendations beginning in 1977 and continue to do so today. Both the ICRP and the NCRP are heavily criticized by both those groups of individuals which believe the risk estimates are underestimated and by those which believe the risks are greatly overestimated. Perhaps both organizations can take some comfort in Saint Thomas Aquinas' suggestion, "In medio virtus." JF - Health physics AU - Meinhold, Charles B Y1 - 2004/09// PY - 2004 DA - September 2004 SP - 9 EP - 248 KW - Radium KW - W90AYD6R3Q KW - Index Medicus KW - United States KW - Erythema -- etiology KW - Radiation Dosage KW - Age Factors KW - History, 20th Century KW - History, 21st Century KW - Humans KW - Congresses as Topic -- history KW - Europe KW - X-Rays KW - International Cooperation KW - Neoplasms -- prevention & control KW - Neoplasms -- etiology KW - Radiation Protection -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66774128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/TOXLINE&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.jtitle=&rft.atitle=&rft.au=Meinhold%2C+Charles+B&rft.aulast=Meinhold&rft.aufirst=Charles&rft.date=2004-09-01&rft.volume=&rft.issue=&rft.spage=240&rft.isbn=&rft.btitle=Lauriston+S.+Taylor+Lecture%3A+The+evolution+of+radiation+protection--from+erythema+to+genetic+risks+to+risks+of+cancer+to...%3F&rft.title=Lauriston+S.+Taylor+Lecture%3A+The+evolution+of+radiation+protection--from+erythema+to+genetic+risks+to+risks+of+cancer+to...%3F&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-14 N1 - Date created - 2004-08-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration. AN - 66680130; 15236349 AB - Methylphenidate (MP) (Ritalin) is widely used for the treatment of attention deficit hyperactivity disorder (ADHD). It is a chiral drug, marketed as the racemic mixture of d- and l-threo enantiomers. Our previous studies (PET and microdialysis) in humans, baboons, and rats confirm the notion that pharmacological specificity of MP resides predominantly in the d-isomer. A recent report that intraperitoneally (i.p.) administered l-threo-MP displayed potent, dose-dependent inhibition of cocaine- or apomorphine-induced locomotion in rats, raises the question of whether l-threo-MP has a similar effect when given orally. It has been speculated that l-threo-MP is poorly absorbed in humans when it is given orally because of rapid presystemic metabolism. To investigate whether l-threo-MP or its metabolites can be delivered to the brain when it is given orally, and whether l-threo-MP is pharmacologically active. PET and MicroPET studies were carried out in baboons and rats using orally delivered C-11-labeled d- and l-threo-MP ([methyl-(11)C]d-threo-MP and [methyl-(11)C]l-threo-MP). In addition, we assessed the effects of i.p. l-threo-MP on spontaneous and cocaine-stimulated locomotor activity in mice. There was a higher global uptake of carbon-11 in both baboon and rat brain for oral [(11)C]l-threo-MP than for oral [(11)C]d-threo-MP. Analysis of the chemical form of radioactivity in rat brain after [(11)C]d-threo-MP indicated mainly unchanged tracer, whereas with [(11)C]l-threo-MP, it was mainly a labeled metabolite. The possibility that this labeled metabolite might be [(11)C]methanol or [(11)C]CO(2), derived from demethylation, was excluded by ex vivo studies in rats. When l-threo-MP was given i.p. to mice at a dose of 3 mg/kg, it neither stimulated locomotor activity nor inhibited the increased locomotor activity due to cocaine administration. These results suggest that, in animal models, l-threo-MP or its metabolite(s) is (are) absorbed from the gastrointestinal tract and enters the brain after oral administration, but that l-threo-MP may not be pharmacologically active. These results are pertinent to the question of whether l-threo-MP contributes to the behavioral and side effect profile of MP during treatment of ADHD. JF - Synapse (New York, N.Y.) AU - Ding, Yu-Shin AU - Gatley, S John AU - Thanos, Panayotis K AU - Shea, Colleen AU - Garza, Victor AU - Xu, Youwen AU - Carter, Pauline AU - King, Payton AU - Warner, Don AU - Taintor, Nicholas B AU - Park, Daniel J AU - Pyatt, Bea AU - Fowler, Joanna S AU - Volkow, Nora D AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. ding@bnl.gov Y1 - 2004/09/01/ PY - 2004 DA - 2004 Sep 01 SP - 168 EP - 175 VL - 53 IS - 3 SN - 0887-4476, 0887-4476 KW - Carbon Radioisotopes KW - 0 KW - Central Nervous System Stimulants KW - Dopamine Uptake Inhibitors KW - Methylphenidate KW - 207ZZ9QZ49 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Papio KW - Administration, Oral KW - Animals KW - Central Nervous System Stimulants -- pharmacology KW - Motor Activity -- physiology KW - Mice KW - Rats KW - Rats, Sprague-Dawley KW - Adsorption -- drug effects KW - Isomerism KW - Tomography, Emission-Computed KW - Motor Activity -- drug effects KW - Cocaine -- pharmacology KW - Drug Synergism KW - Female KW - Male KW - Dopamine Uptake Inhibitors -- pharmacology KW - Brain -- drug effects KW - Methylphenidate -- pharmacokinetics KW - Brain -- metabolism KW - Methylphenidate -- analogs & derivatives KW - Brain -- diagnostic imaging KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66680130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Brain+kinetics+of+methylphenidate+%28Ritalin%29+enantiomers+after+oral+administration.&rft.au=Ding%2C+Yu-Shin%3BGatley%2C+S+John%3BThanos%2C+Panayotis+K%3BShea%2C+Colleen%3BGarza%2C+Victor%3BXu%2C+Youwen%3BCarter%2C+Pauline%3BKing%2C+Payton%3BWarner%2C+Don%3BTaintor%2C+Nicholas+B%3BPark%2C+Daniel+J%3BPyatt%2C+Bea%3BFowler%2C+Joanna+S%3BVolkow%2C+Nora+D&rft.aulast=Ding&rft.aufirst=Yu-Shin&rft.date=2004-09-01&rft.volume=53&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-09 N1 - Date created - 2004-07-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Pressure-induced migration of zeolitic water in laumontite AN - 51743820; 2005-021863 JF - Physics and Chemistry of Minerals AU - Lee, Y AU - Hriljac, J A AU - Vogt, T Y1 - 2004/09// PY - 2004 DA - September 2004 SP - 421 EP - 428 PB - Springer-Verlag, Berlin-New York VL - 31 IS - 7 SN - 0342-1791, 0342-1791 KW - water KW - United States KW - silicates KW - laumontite KW - experimental studies KW - pressure KW - X-ray diffraction data KW - natural materials KW - Litchfield County Connecticut KW - crystal structure KW - Rietveld refinement KW - powder method KW - high pressure KW - Connecticut KW - order-disorder KW - sample preparation KW - Pleasant Valley Connecticut KW - phase equilibria KW - zeolite group KW - framework silicates KW - hydrostatic pressure KW - geophysics KW - 01B:Mineralogy of silicates KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51743820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Slotted+Surface+Coil+for+Magnetic+Resonance+Imaging+at+4T&rft.au=Solis%2C+Sergio%3BWang%2C+Ruiliang%3BTomasi%2C+Dardo%3BRodriguez%2C+Alfredo+Odon&rft.aulast=Solis&rft.aufirst=Sergio&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.springerlink.com/content/100449/?p=e597e977f1914094b3810f7e67f0a453&pi=0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 27 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PCMIDU N1 - SubjectsTermNotLitGenreText - Connecticut; crystal structure; experimental studies; framework silicates; geophysics; high pressure; hydrostatic pressure; laumontite; Litchfield County Connecticut; natural materials; order-disorder; phase equilibria; Pleasant Valley Connecticut; powder method; pressure; Rietveld refinement; sample preparation; silicates; United States; water; X-ray diffraction data; zeolite group DO - http://dx.doi.org/10.1007/s00269-004-0414-y ER - TY - JOUR T1 - Ground-based and aircraft measurements of trace gases in Phoenix, Arizona (1998) AN - 16187832; 5999329 AB - In May and June of 1998, an extensive measurement campaign was fielded in the city of Phoenix and its environs. Measurements were made at ground sites and aboard the Department of Energy's G-1 research aircraft in an effort to understand the production of O sub(3) in this area. Diurnal variations in O sub(3) differed at the upwind Palo Verde, downtown Phoenix Super Site, and downwind Usery Pass surface stations. Air masses entering the metropolitan area had O sub(3) concentrations greater than 40 ppbv. Maximum O sub(3) concentrations near 100 ppbv were observed downtown at 14:00 local standard time; similar concentrations occurred much later in the day at the downwind site. One aircraft case study on 5 June, 1998 is presented to illustrate ozone production in the region. Calculated ozone production rate and efficiency varied from 1 to 7 ppbv h super(-1), and 1-3 molecules of O sub(3) per molecule of NO sub(z), respectively, for this flight. Hydrocarbon apportionment, based upon ground site and aircraft measurements, establishes that biogenic species are not significant contributors to O sub(3) production in the Phoenix area. Therefore, carbon monoxide becomes a major contributor to OH reactivity as the more reactive anthropogenic hydrocarbons become depleted. The relatively low ozone production observed in this study is attributed to a low rate of radical production in the dry atmosphere. JF - Atmospheric Environment AU - Nunnermacker, L J AU - Weinstein-Lloyd, J AU - Kleinman, L AU - Daum, PH AU - Lee, Y N AU - Springston AU - Klotz, P AU - Newman, L AU - Neuroth, G AU - Hyde, P AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Bldg. 815E, Rutherford St. Upton, NY 11973, USA, lindan@bnl.gov Y1 - 2004/09// PY - 2004 DA - Sep 2004 SP - 4941 EP - 4956 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 29 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Ozone KW - Ozone production efficiency KW - Biogenic hydrocarbons KW - Isoprene KW - Carbon monoxide KW - Nitrogen oxides KW - Diurnal variations KW - Hydrocarbons KW - Aircraft observations KW - Atmosphere KW - Trace gases in atmosphere KW - Ozone production KW - Gases KW - Photochemicals KW - Aircraft KW - Atmospheric chemistry KW - Emission standards KW - Urban atmospheric pollution KW - USA, Arizona, Phoenix KW - Urban areas KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16187832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Ground-based+and+aircraft+measurements+of+trace+gases+in+Phoenix%2C+Arizona+%281998%29&rft.au=Nunnermacker%2C+L+J%3BWeinstein-Lloyd%2C+J%3BKleinman%2C+L%3BDaum%2C+PH%3BLee%2C+Y+N%3BSpringston%3BKlotz%2C+P%3BNewman%2C+L%3BNeuroth%2C+G%3BHyde%2C+P&rft.aulast=Nunnermacker&rft.aufirst=L&rft.date=2004-09-01&rft.volume=38&rft.issue=29&rft.spage=4941&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2004.04.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2004-10-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Diurnal variations; Ozone production; Trace gases in atmosphere; Atmospheric chemistry; Aircraft observations; Urban atmospheric pollution; Ozone; Carbon monoxide; Photochemicals; Gases; Aircraft; Hydrocarbons; Emission standards; Nitrogen oxides; Atmosphere; Urban areas; USA, Arizona, Phoenix DO - http://dx.doi.org/10.1016/j.atmosenv.2004.04.033 ER - TY - JOUR T1 - Are endogenous clustered DNA damages induced in human cells? AN - 66716861; 15256220 AB - Although clustered DNA damages are induced in cells by ionizing radiation and can be induced artifactually during DNA isolation, it was not known if they are formed in unirradiated cells by normal oxidative metabolism. Using high-sensitivity methods of quantitative gel electrophoresis, electronic imaging, and number average length analysis, we found that two radiosensitive human cell lines (TK6 and WI-L2-NS) accumulated Fpg-oxidized purine clusters and Nth-oxidized pyrimidine clusters but not Nfo-abasic clusters. However, four repair-proficient human lines (MOLT 4, HL-60, WTK1, and 28SC) did not contain significant levels (<5/Gbp) of any cluster type. Cluster levels were independent of p53 status. Measurement of glycosylase levels in 28SC, TK6, and WI-L2-NS cells suggested that depressed hOGG1 and hNth activities in TK6 and WI-L2-NS could be related to oxybase cluster accumulation. Thus, individuals with DNA repair enzyme deficiencies could accumulate potentially cytotoxic and mutagenic clustered DNA damages. The absence of Nfo-detected endogenous clusters in any cells examined suggests that abasic clusters could be a signature of cellular ionizing radiation exposure. JF - Free radical biology & medicine AU - Bennett, Paula V AU - Cintron, Nela S AU - Gros, Laurent AU - Laval, Jacques AU - Sutherland, Betsy M AD - Department of Biology, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2004/08/15/ PY - 2004 DA - 2004 Aug 15 SP - 488 EP - 499 VL - 37 IS - 4 SN - 0891-5849, 0891-5849 KW - Mutagens KW - 0 KW - Oligonucleotides KW - Purines KW - Pyrimidines KW - Tumor Suppressor Protein p53 KW - DNA KW - 9007-49-2 KW - Pyruvate Kinase KW - EC 2.7.1.40 KW - DNA Glycosylases KW - EC 3.2.2.- KW - Index Medicus KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Sensitivity and Specificity KW - Pyrimidines -- chemistry KW - Escherichia coli -- metabolism KW - DNA Repair KW - Electrophoresis KW - HL-60 Cells KW - DNA -- metabolism KW - Humans KW - Cell Line, Tumor KW - Tumor Suppressor Protein p53 -- metabolism KW - Oxidation-Reduction KW - Oligonucleotides -- chemistry KW - DNA Glycosylases -- metabolism KW - Oxidative Stress KW - Purines -- chemistry KW - Cell Line KW - Radiation, Ionizing KW - Pyruvate Kinase -- metabolism KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66716861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Are+endogenous+clustered+DNA+damages+induced+in+human+cells%3F&rft.au=Bennett%2C+Paula+V%3BCintron%2C+Nela+S%3BGros%2C+Laurent%3BLaval%2C+Jacques%3BSutherland%2C+Betsy+M&rft.aulast=Bennett&rft.aufirst=Paula&rft.date=2004-08-15&rft.volume=37&rft.issue=4&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-31 N1 - Date created - 2004-07-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Responses to low doses of ionizing radiation in biological systems. AN - 733324343; 19330141 AB - Biological tissues operate through cells that act together within signaling networks. These assure coordinated cell function in the face of constant exposure to an array of potentially toxic agents, externally from the environment and endogenously from metabolism. Living tissues are indeed complex adaptive systems.To examine tissue effects specific for low-dose radiation, (1) absorbed dose in tissue is replaced by the sum of the energies deposited by each track event, or hit, in a cell-equivalent tissue micromass (1 ng) in all micromasses exposed, that is, by the mean energy delivered by all microdose hits in the exposed micromasses, with cell dose expressing the total energy per micromass from multiple microdoses; and (2) tissue effects are related to cell damage and protective cellular responses per average microdose hit from a given radiation quality for all such hits in the exposed micromasses.The probability of immediate DNA damage per low-linear-energy-transfer (LET) average micro-dose hit is extremely small, increasing over a certain dose range in proportion to the number of hits. Delayed temporary adaptive protection (AP) involves (a) induced detoxification of reactive oxygen species, (b) enhanced rate of DNA repair, (c) induced removal of damaged cells by apoptosis followed by normal cell replacement and by cell differentiation, and (d) stimulated immune response, all with corresponding changes in gene expression. These AP categories may last from less than a day to weeks and be tested by cell responses against renewed irradiation. They operate physiologically against nonradiogenic, largely endogenous DNA damage, which occurs abundantly and continually. Background radiation damage caused by rare microdose hits per micromass is many orders of magnitude less frequent. Except for apoptosis, AP increasingly fails above about 200 mGy of low-LET radiation, corresponding to about 200 microdose hits per exposed micromass. This ratio appears to exceed approximately 1 per day for protracted exposure. The balance between damage and protection favors protection at low cell doses and damage at high cell doses. Bystander effects from high-dosed cells to nonirradiated neighboring cells appear to include both damage and protection.Regarding oncogenesis, a model based on the aforementioned dual response pattern at low doses and dose rates is consistant with the nonlinear reponse data and contradicts the linear no-threshold dose-risk hypothesis for radiation-induced cancer. Indeed, a dose-cancer risk function should include both linear and nonlinear terms. JF - Nonlinearity in biology, toxicology, medicine AU - Feinendegen, Ludwig E AU - Pollycove, Myron AU - Sondhaus, Charles A AD - Nuclear Medicine, Heinrich-Heine-University Düsseldorf, Germany; and Medical Department, Brookhaven National Laboratory, Upton, New York. Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 143 EP - 171 VL - 2 IS - 3 SN - 1540-1421, 1540-1421 KW - radiation low-dose effects KW - hormesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733324343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nonlinearity+in+biology%2C+toxicology%2C+medicine&rft.atitle=Responses+to+low+doses+of+ionizing+radiation+in+biological+systems.&rft.au=Feinendegen%2C+Ludwig+E%3BPollycove%2C+Myron%3BSondhaus%2C+Charles+A&rft.aulast=Feinendegen&rft.aufirst=Ludwig&rft.date=2004-07-01&rft.volume=2&rft.issue=3&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Nonlinearity+in+biology%2C+toxicology%2C+medicine&rft.issn=15401421&rft_id=info:doi/10.1080%2F15401420490507431 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Radiat Prot Dosimetry. 2002;99(1-4):249-51 [12194297] Cancer Res. 1992 Nov 15;52(22):6394-6 [1423287] Science. 1972 Jan 14;175(4018):200-2 [5008441] Int J Radiat Biol. 1999 Jul;75(7):865-73 [10489898] Radiat Environ Biophys. 2000 Jun;39(2):79-87 [10929376] J Nucl Med. 2001 Sep;42(9):26N-32N, 37N [11554390] Science. 1984 Feb 10;223(4636):594-7 [6695170] J Gerontol. 1956 Jul;11(3):298-300 [13332224] Radiat Res. 1998 Mar;149(3):256-62 [9496888] Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jan;53(1):39-47 [3257477] Radiat Res. 1974 Sep;59(3):693-709 [4428016] Adv Biol Med Phys. 1967;11:27-85 [4860235] Int J Radiat Biol. 2002 Oct;78(10):913-21 [12465656] C R Acad Sci III. 1999 Feb-Mar;322(2-3):245-51 [10196680] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5057-62 [12679524] Mutat Res. 1995 Mar;336(2):101-13 [7885381] Mutat Res. 1996 Nov 4;358(2):193-8 [8946024] Hum Exp Toxicol. 1999 Jul;18(7):426-32 [10454071] Environ Health Perspect. 1998 Feb;106 Suppl 1:277-83 [9539019] Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Jan;39(1):83-93 [6971822] Radiat Res. 2003 Mar;159(3):320-7 [12600234] Radiat Res. 1992 Jul;131(1):66-71 [1626050] Int J Radiat Biol. 1992 Aug;62(2):177-86 [1355511] Hum Exp Toxicol. 2002 Feb;21(2):65-9 [12102498] Nat Med. 1996 May;2(5):577-80 [8616719] Int J Radiat Biol. 1989 Jul;56(1):107-18 [2569006] Int J Radiat Biol. 2003 Feb;79(2):99-105 [12569013] Int J Radiat Biol. 1997 Apr;71(4):421-7 [9154145] Stem Cells. 1995 May;13 Suppl 1:7-20 [7488971] Int J Radiat Biol. 1998 May;73(5):535-41 [9652811] J Nucl Med. 2001 Jan;42(1):17-20 [11197970] Hum Exp Toxicol. 2002 Feb;21(2):85-90 [12102502] Radiat Res. 1998 May;149(5):517-20 [9588363] J Nucl Med. 2003 Jan;44(1):125; author reply 125-6 [12515886] Nature. 2000 Nov 9;408(6809):239-47 [11089981] Radiat Res. 2001 Aug;156(2):177-80 [11448238] Br J Cancer. 2000 Nov;83(9):1223-30 [11027437] Mutat Res. 1996 Nov 4;358(2):171-83 [8946022] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5061-6 [9560228] Radiat Prot Dosimetry. 2003;105(1-4):39-42 [14526924] Int J Radiat Biol. 1999 Jun;75(6):681-90 [10404997] Radiat Res. 1998 Nov;150(5):497-504 [9806590] Radiat Environ Biophys. 1997 Jun;36(2):85-8 [9271795] Free Radic Biol Med. 1991;11(3):299-306 [1937147] Nature. 1977 Oct 6;269(5628):518-21 [909602] Philos Trans R Soc Lond B Biol Sci. 1996 Nov 29;351(1347):1529-38 [8962440] Radiat Res. 1998 Nov;150(5 Suppl):S60-79 [9806610] Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jan;53(1):95-102 [3123411] Anticancer Res. 2000 Nov-Dec;20(6B):4115-39 [11205238] Int J Radiat Biol. 2001 May;77(5):541-51 [11382332] Radiat Res. 2002 Nov;158(5):626-33 [12385640] C R Acad Sci III. 1999 Feb-Mar;322(2-3):167-75 [10196669] Radiat Res. 2001 Nov;156(5 Pt 2):618-27 [11604083] Science. 2001 Feb 16;291(5507):1284-9 [11181991] Carcinogenesis. 2000 Mar;21(3):397-404 [10688860] J ICRU. 2011 Apr;11(1):1-31 [24174259] Radiat Environ Biophys. 1999 May;38(1):57-71 [10384956] Radiat Res. 1999 Jun;151(6):717-24 [10360792] Radiat Environ Biophys. 1990;29(4):273-92 [2281134] Radiat Res. 2002 Aug;158(2):181-6 [12105988] Prog Nucleic Acid Res Mol Biol. 1988;35:95-125 [3065826] Health Phys. 1987 May;52(5):663-9 [3570805] Hum Exp Toxicol. 2003 Jun;22(6):290-306; discussion 307, 315-7, 319-23 [12856953] Int J Radiat Biol. 1995 Jul;68(1):47-54 [7629437] Radiat Res. 1998 Dec;150(6):656-62 [9840185] Radiat Res. 1999 Sep;152(3):225-31 [10453082] Free Radic Biol Med. 2000 Aug;29(3-4):323-33 [11035261] Physiol Rev. 1998 Apr;78(2):547-81 [9562038] Radiat Res. 2001 Mar;155(3):397-401 [11182789] Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Mar;45(3):205-15 [6370884] Radiat Res. 2001 Dec;156(6):700-7 [11741493] Radiat Res. 2001 Mar;155(3):402-8 [11182790] Nucleic Acids Res. 1996 Apr 15;24(8):1389-94 [8628669] Mutat Res. 1996 Nov 4;358(2):143-53 [8946019] Radiat Res. 2001 Mar;155(3):387-96 [11182788] Mutat Res. 1992 Sep;275(3-6):257-66 [1383768] Mutat Res. 1996 Nov 4;358(2):185-91 [8946023] Proc Natl Acad Sci U S A. 2000 May 9;97(10):5381-6 [10792040] Biol Pharm Bull. 2003 Jan;26(1):19-23 [12520165] Biochim Biophys Acta. 1998 Aug 24;1381(3):312-8 [9729439] Radiat Res. 2002 Mar;157(3):275-80 [11839089] Health Phys. 1995 Jun;68(6):786-92 [7759256] Eur J Nucl Med. 1991;18(9):740-51 [1936050] Radiat Res. 1996 Oct;146(4):369-73 [8927708] Health Phys. 1990 Jul;59(1):29-34 [2358357] Science. 1998 May 15;280(5366):1066-9 [9582118] J Nucl Med. 2001 Jul;42(7):17N-27N [11441881] Radiat Res. 2003 Sep;160(3):376-9 [12926996] Drug Metab Rev. 1998 May;30(2):225-43 [9606602] Radiat Res. 2003 Jan;159(1):102-8 [12492373] Int J Radiat Biol. 2002 Oct;78(10):931-6 [12465658] N1 - Last updated - 2017-02-22 DO - http://dx.doi.org/10.1080/15401420490507431 ER - TY - JOUR T1 - Synthesis of copper octabromotetracarboranylphenylporphyrin for boron neutron capture therapy and its toxicity and biodistribution in tumour-bearing mice. AN - 66682583; 15238404 AB - Copper tetracarboranyltetraphenylporphyrin (CuTCPH) is a minimally toxic carborane-containing porphyrin that has safely delivered high concentrations of boron for experimental boron neutron capture therapy (BNCT). Copper octabromotetracarboranylphenylporphyrin (CuTCPBr), synthesized by bromination of CuTCPH, is one of several new minimally toxic analogues of CuTCPH being studied in our laboratory, which could possess comparable or better tumour-targeting properties with enhanced tumour cytotoxicity. Its biodistribution, biokinetics and toxicity in mice with subcutaneous EMT-6 (mammary) or SCCVII (squamous cell) carcinomas were compared with those of CuTCPH. The administration of approximately 200 mg kg(-1) of either porphyrin in six intraperitoneal injections over 2 days had no apparent effect, but administration of approximately 400 mg kg(-1) slightly lowered body weights, elevated alanine and aspartate transaminase activities in blood plasma, and depressed blood platelet counts for several days. Enzymes and platelets returned to normal within 5 days after those injections and body weights returned to normal within 2 weeks. High average concentrations of boron from either porphyrin were achieved in the two tumour models from a total dose of approximately 200 mg kg(-1). The high tumour boron concentration decreased slowly while concentrations in blood decreased rapidly. Boron concentrations in brain and skin were consistently lower than in tumour by a factor of 10 or more. Although either CuTCPH or CuTCPBr can be labelled with (64)Cu for imaging by positron emission tomography (PET), CuTCPBr can also be labelled by (76)Br, another PET-imageable nuclide. JF - The British journal of radiology AU - Miura, M AU - Morris, G M AU - Micca, P L AU - Nawrocky, M M AU - Makar, M S AU - Cook, S P AU - Slatkin, D N AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 573 EP - 580 VL - 77 IS - 919 SN - 0007-1285, 0007-1285 KW - Metalloporphyrins KW - 0 KW - copper tetracarboranyltetraphenylporphyrin KW - Boron KW - N9E3X5056Q KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Dose-Response Relationship, Drug KW - Mice, Inbred C3H KW - Mice KW - Tissue Distribution KW - Mice, Inbred BALB C KW - Boron -- pharmacokinetics KW - Female KW - Boron Neutron Capture Therapy -- adverse effects KW - Mammary Neoplasms, Experimental -- radiotherapy KW - Carcinoma, Squamous Cell -- metabolism KW - Boron Neutron Capture Therapy -- methods KW - Mammary Neoplasms, Experimental -- metabolism KW - Carcinoma, Squamous Cell -- radiotherapy KW - Metalloporphyrins -- chemical synthesis KW - Metalloporphyrins -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66682583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+radiology&rft.atitle=Synthesis+of+copper+octabromotetracarboranylphenylporphyrin+for+boron+neutron+capture+therapy+and+its+toxicity+and+biodistribution+in+tumour-bearing+mice.&rft.au=Miura%2C+M%3BMorris%2C+G+M%3BMicca%2C+P+L%3BNawrocky%2C+M+M%3BMakar%2C+M+S%3BCook%2C+S+P%3BSlatkin%2C+D+N&rft.aulast=Miura&rft.aufirst=M&rft.date=2004-07-01&rft.volume=77&rft.issue=919&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+radiology&rft.issn=00071285&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-30 N1 - Date created - 2004-07-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Saharan dust aerosol radiative forcing measured from space AN - 51503020; 2007-007033 JF - Journal of Climate AU - Li, F AU - Vogelmann, A M AU - Ramanathan, V Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 2558 EP - 2571 PB - American Meteorological Society, Boston, MA VL - 17 IS - 13 SN - 0894-8755, 0894-8755 KW - monthly variations KW - clastic sediments KW - CERES KW - environmental analysis KW - physical properties KW - atmospheric transport KW - dust KW - sediments KW - Africa KW - aerosols KW - Sahara KW - diurnal variations KW - wind transport KW - chemical composition KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51503020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Climate&rft.atitle=Saharan+dust+aerosol+radiative+forcing+measured+from+space&rft.au=Li%2C+F%3BVogelmann%2C+A+M%3BRamanathan%2C+V&rft.aulast=Li&rft.aufirst=F&rft.date=2004-07-01&rft.volume=17&rft.issue=13&rft.spage=2558&rft.isbn=&rft.btitle=&rft.title=Journal+of+Climate&rft.issn=08948755&rft_id=info:doi/ L2 - http://journals.ametsoc.org/loi/clim LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 34 N1 - PubXState - MA N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aerosols; Africa; atmospheric transport; CERES; chemical composition; clastic sediments; diurnal variations; dust; environmental analysis; monthly variations; physical properties; Sahara; sediments; wind transport ER - TY - JOUR T1 - Structural effects of radiation damage and its potential for phasing. AN - 71936402; 15159568 AB - A detailed analysis of radiation-damage-induced structural and intensity changes is presented on the model protein thaumatin. Changes in reflection intensities induced by irradiation display a parabolic character. The most pronounced structural changes observed were disulfide-bond breakage and associated main-chain and side-chain movements as well as decarboxylation of aspartate and glutamate residues. The structural changes induced on the sulfur atoms were successfully used to obtain high-quality phase estimates via an RIP procedure. Results obtained with ACORN suggest that the contribution originating from the partial structure may play an important role in phasing even at less than atomic resolution. JF - Acta crystallographica. Section D, Biological crystallography AU - Banumathi, Sankaran AU - Zwart, Petrus H AU - Ramagopal, Udupi A AU - Dauter, Miroslawa AU - Dauter, Zbigniew AD - Synchotron Radiation Research Section, MCL, National Cancer Institute, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2004/06// PY - 2004 DA - June 2004 SP - 1085 EP - 1093 VL - 60 SN - 0907-4449, 0907-4449 KW - Plant Proteins KW - 0 KW - Aspartic Acid KW - 30KYC7MIAI KW - Glutamic Acid KW - 3KX376GY7L KW - thaumatin protein, plant KW - 53850-34-3 KW - Sulfur KW - 70FD1KFU70 KW - Index Medicus KW - X-Ray Diffraction KW - Models, Molecular KW - Glutamic Acid -- chemistry KW - Models, Statistical KW - Sulfur -- chemistry KW - Aspartic Acid -- chemistry KW - Protein Conformation KW - Models, Theoretical KW - Plant Proteins -- chemistry KW - Radiation Effects KW - Crystallography, X-Ray -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71936402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.atitle=Structural+effects+of+radiation+damage+and+its+potential+for+phasing.&rft.au=Banumathi%2C+Sankaran%3BZwart%2C+Petrus+H%3BRamagopal%2C+Udupi+A%3BDauter%2C+Miroslawa%3BDauter%2C+Zbigniew&rft.aulast=Banumathi&rft.aufirst=Sankaran&rft.date=2004-06-01&rft.volume=60&rft.issue=&rft.spage=1085&rft.isbn=&rft.btitle=&rft.title=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.issn=09074449&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-31 N1 - Date created - 2004-05-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Biodistribution of Radioiodinated Adenovirus Fiber Protein Knob Domain after Intravenous Injection in Mice AN - 17978181; 5917797 AB - The knob domains from the fiber proteins of adenovirus serotypes 2 and 12 were labeled with radioiodine and then injected into the bloodstreams of mice. Knob proteins with functional binding sites for the coxsackie and adenovirus receptor (CAR) were cleared rapidly from the circulation, with radioactivity appearing predominantly in the stomach, while knob mutants unable to bind to CAR remained in the blood circulation for a prolonged period. The clearance of radiolabeled wild-type knob from the blood was slowed by coinjecting an excess of unlabeled wild-type knob protein. An earlier study showed that super(99m)Tc- labeled knob protein with intact CAR-binding activity also cleared rapidly from the blood circulation of mice, with radioactivity accumulating predominantly in the liver (K. R. Zinn et al., Gene Ther. 5:798-808, 1998). Together these results suggest that rapid clearance of knob protein from the blood results from specific binding to CAR in the liver and that the bound knob then enters a degradative pathway. The elevated levels of radioiodine in the stomach observed in our experiments are consistent with deiodination of labeled knob by dehalogenases in hepatocyte microsomes and uptake of the resultant free radioiodine by Na/I symporters in the gastric mucosa. Although CAR has been shown to localize in tight junctions of polarized epithelial cells, where it functions in intercellular adhesion, the results of our study suggest that a subset of CAR molecules in the liver is highly accessible to ligands in the blood and able to rapidly deliver bound ligand to an intracellular degradative compartment. JF - Journal of Virology AU - Awasthi, V AU - Meinken, G AU - Springer, K AU - Srivastava, S C AU - Freimuth, P AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, freimuth@bnl.gov Y1 - 2004/06// PY - 2004 DA - Jun 2004 SP - 6431 EP - 6438 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 78 IS - 12 SN - 0022-538X, 0022-538X KW - knob proteins KW - fiber proteins KW - intravenous administration KW - mice KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Radioiodination KW - Adenovirus KW - V 22150:Animal models & experimentally-induced viral infections KW - W 30965:Miscellaneous, Reviews KW - W3 33250:Methods: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17978181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Biodistribution+of+Radioiodinated+Adenovirus+Fiber+Protein+Knob+Domain+after+Intravenous+Injection+in+Mice&rft.au=Awasthi%2C+V%3BMeinken%2C+G%3BSpringer%2C+K%3BSrivastava%2C+S+C%3BFreimuth%2C+P&rft.aulast=Awasthi&rft.aufirst=V&rft.date=2004-06-01&rft.volume=78&rft.issue=12&rft.spage=6431&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.78.12.6431-6438.2004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Adenovirus; Radioiodination DO - http://dx.doi.org/10.1128/JVI.78.12.6431-6438.2004 ER - TY - JOUR T1 - Structural Analysis of Botulinum Neurotoxin Type E Catalytic Domain and Its Mutant Glu212 arrow right Gln Reveals the Pivotal Role of the Glu212 Carboxylate in the Catalytic Pathway AN - 17820225; 5936596 AB - The seven serotypes of botulinum neurotoxins (A-G) produced by Clostridium botulinum share significant sequence homology and structural similarity. The functions of their individual domains and the modes of action are also similar. However, the substrate specificity and the peptide bond cleavage selectivity of their catalytic domains are different. The reason for this unique specificity of botulinum neurotoxins is still baffling. If an inhibitor leading to a therapeutic drug common to all serotypes is to be developed, it is essential to understand the differences in their three-dimensional structures that empower them with this unique characteristic. Accordingly, high-resolution structures of all serotypes are required, and toward achieving this goal the crystal structure of the catalytic domain of C. botulinum neurotoxin type E has been determined to 2.1 AA resolution. The crystal structure of the inactive mutant Glu212 arrow right Gln of this protein has also been determined. While the overall conformation is unaltered in the active site, the position of the nucleophilic water changes in the mutant, thereby causing it to lose its ability to activate the catalytic reaction. The structure explains the importance of the nucleophilic water and the charge on Glu212. The structural differences responsible for the loss of activity of the mutant provide a common model for the catalytic pathway of Clostridium neurotoxins since Glu212 is conserved and has a similar role in all serotypes. This or a more nonconservative mutant (e.g., Glu212 arrow right Ala) could provide a novel, genetically modified protein vaccine for botulinum. JF - Biochemistry (Washington) AU - Agarwal, R AU - Eswaramoorthy, S AU - Kumaran, D AU - Binz, T AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA Y1 - 2004/06/01/ PY - 2004 DA - 2004 Jun 01 SP - 6637 EP - 6644 VL - 43 IS - 21 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Serotypes KW - Crystal structure KW - Substrate specificity KW - Vaccines KW - Clostridium botulinum KW - Neurotoxins KW - Drugs KW - Models KW - J 02822:Biosynthesis and physicochemical properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17820225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structural+Analysis+of+Botulinum+Neurotoxin+Type+E+Catalytic+Domain+and+Its+Mutant+Glu212+arrow+right+Gln+Reveals+the+Pivotal+Role+of+the+Glu212+Carboxylate+in+the+Catalytic+Pathway&rft.au=Agarwal%2C+R%3BEswaramoorthy%2C+S%3BKumaran%2C+D%3BBinz%2C+T%3BSwaminathan%2C+S&rft.aulast=Agarwal&rft.aufirst=R&rft.date=2004-06-01&rft.volume=43&rft.issue=21&rft.spage=6637&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi036278w LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Clostridium botulinum; Neurotoxins; Serotypes; Crystal structure; Vaccines; Drugs; Substrate specificity; Models DO - http://dx.doi.org/10.1021/bi036278w ER - TY - JOUR T1 - Radiation dosimetry of a graphite moderated radium-beryllium source. AN - 71804080; 15069300 AB - The Brookhaven National Laboratory Sigma Pile is a radium-beryllium neutron source imbedded in a cube of graphite blocks. The pile is approximately 2.13 m on four sides and is 3.07 m high. Thermoluminescent dosimeters were used to determine the neutron and gamma-ray dose rates in the pile. Gamma-ray dose rate measurements have also been made in the air outside of the pile, while the radium-beryllium neutron source was being withdrawn from the pile. The Monte Carlo code has been used to calculate the coupled neutron-photon transport. Measured dose rates at various locations agreed with the calculated values within 5% to 15%. JF - Health physics AU - Holden, Norman E AU - Reciniello, Richard N AU - Hu, Jih-Perng AD - National Nuclear Data Center, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. holden@bnl.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - S110 EP - S112 VL - 86 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Radioisotopes KW - 0 KW - Graphite KW - 7782-42-5 KW - Beryllium KW - OW5102UV6N KW - Radium KW - W90AYD6R3Q KW - Index Medicus KW - Neutrons KW - Radiation Dosage KW - Radiometry -- instrumentation KW - Gamma Rays KW - Body Burden KW - Radioisotopes -- analysis KW - Radiometry -- methods KW - Thermoluminescent Dosimetry -- methods KW - Thermoluminescent Dosimetry -- instrumentation KW - Radiation Protection -- methods KW - Algorithms KW - Radium -- analysis KW - Risk Assessment -- methods KW - Beryllium -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71804080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Radiation+dosimetry+of+a+graphite+moderated+radium-beryllium+source.&rft.au=Holden%2C+Norman+E%3BReciniello%2C+Richard+N%3BHu%2C+Jih-Perng&rft.aulast=Holden&rft.aufirst=Norman&rft.date=2004-05-01&rft.volume=86&rft.issue=5+Suppl&rft.spage=S110&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-21 N1 - Date created - 2004-04-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Optimization of the epithermal neutron beam for Boron Neutron Capture Therapy at the Brookhaven Medical Research Reactor. AN - 71802751; 15069299 AB - The use of epithermal neutron beam in clinical trials of Boron Neutron Capture Therapy for patients with malignant brain tumors had been carried out for half a decade at the Brookhaven's Medical Reactor. The decision to permanently close this reactor in 2000 cut short the efforts to implement a new conceptual design to optimize this beam in preparation for use with possible new BNCT protocols. Details of the conceptual design to produce a highly intensified and focused neutron beam with less gamma and neutron contamination in tissues are presented here for their potential applicability to other reactor facilities. Neutron-photon coupled Monte Carlo calculations were used to predict the flux, current, heating, and absorbed dose produced by the proposed design. The results were benchmarked by the dose rate and flux measurements taken at the facility then in use. JF - Health physics AU - Hu, Jih-Perng AU - Reciniello, Richard N AU - Holden, Norman E AD - Brookhaven National Laboratory, Upton, NY 11973-5000, USA. hu1@bnl.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - S103 EP - S109 VL - 86 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Index Medicus KW - New York KW - Computer Simulation KW - Radiotherapy Dosage KW - Humans KW - Academies and Institutes KW - Models, Statistical KW - Computer-Aided Design KW - Quality Control KW - Boron Neutron Capture Therapy -- instrumentation KW - Radiation Protection -- methods KW - Neoplasms -- radiotherapy KW - Radiotherapy Planning, Computer-Assisted -- methods KW - Equipment Failure Analysis -- methods KW - Boron Neutron Capture Therapy -- methods KW - Radiometry -- methods KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71802751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Optimization+of+the+epithermal+neutron+beam+for+Boron+Neutron+Capture+Therapy+at+the+Brookhaven+Medical+Research+Reactor.&rft.au=Hu%2C+Jih-Perng%3BReciniello%2C+Richard+N%3BHolden%2C+Norman+E&rft.aulast=Hu&rft.aufirst=Jih-Perng&rft.date=2004-05-01&rft.volume=86&rft.issue=5+Suppl&rft.spage=S103&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-21 N1 - Date created - 2004-04-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Engineered endophytic bacteria improve phytoremediation of water-soluble, volatile, organic pollutants AN - 18051779; 5916953 AB - Phytoremediation of highly water soluble and volatile organic xenobiotics is often inefficient because plants do not completely degrade these compounds through their rhizospheres. This results in phytotoxicity and/or volatilization of chemicals through the leaves, which can cause additional environmental problems. We demonstrate that endophytic bacteria equipped with the appropriate degradation pathway improve the in planta degradation of toluene. We introduced the pTOM toluene-degradation plasmid of Burkholderia cepacia G4 into B. cepacia L.S.2.4, a natural endophyte of yellow lupine. After surface-sterilized lupine seeds were successfully inoculated with the recombinant strain, the engineered endophytic bacteria strongly degraded toluene, resulting in a marked decrease in its phytotoxicity, and a 50-70% reduction of its evapotranspiration through the leaves. This strategy promises to improve the efficiency of phytoremediating volatile organic contaminants. JF - Nature Biotechnology AU - Barac, T AU - Taghavi, S AU - Borremans, B AU - Provoost, A AU - Oeyen, L AU - Colpaert, J V AU - Vangronsveld, J AU - van der Lelie, D AD - Flemish Institute for Technological Research (VITO), Environmental Technology Expertise Center, Boeretang 200, B-2400 Mol, Belgium, vdlelied@bnl.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 583 EP - 588 VL - 22 IS - 5 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Biodegradation KW - Toluene KW - Rhizosphere KW - Xenobiotics KW - Burkholderia cepacia KW - Pollutants KW - phytoremediation KW - Seeds KW - Endophytes KW - Leaves KW - Volatilization KW - Evapotranspiration KW - Plasmids KW - Volatiles KW - Phytotoxicity KW - Contaminants KW - W2 32510:Waste treatment, environment, pollution KW - W 30965:Miscellaneous, Reviews KW - W4 210:Bioremediation, Bioreactors & BioCycling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18051779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Engineered+endophytic+bacteria+improve+phytoremediation+of+water-soluble%2C+volatile%2C+organic+pollutants&rft.au=Barac%2C+T%3BTaghavi%2C+S%3BBorremans%2C+B%3BProvoost%2C+A%3BOeyen%2C+L%3BColpaert%2C+J+V%3BVangronsveld%2C+J%3Bvan+der+Lelie%2C+D&rft.aulast=Barac&rft.aufirst=T&rft.date=2004-05-01&rft.volume=22&rft.issue=5&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt960 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Burkholderia cepacia; Rhizosphere; Endophytes; Volatiles; Phytotoxicity; Biodegradation; phytoremediation; Leaves; Toluene; Seeds; Volatilization; Xenobiotics; Evapotranspiration; Pollutants; Plasmids; Contaminants DO - http://dx.doi.org/10.1038/nbt960 ER - TY - JOUR T1 - Thermodynamic Studies of the Mechanism of Metal Binding to the Escherichia coli Zinc Transporter YiiP AN - 18048225; 5881055 AB - Sequence homology of the Escherichia coli YiiP places it within the family of cation diffusion facilitators, a family of membrane transporters that play a central role in regulating cellular zinc homeostasis. Here we describe the first thermodynamic and mechanistic studies of metal binding to a cation diffusion facilitator. Isothermal titration calorimetric analyses of the purified YiiP and binding competitions among Zn super(2+), Cd super(2+), and Hg super(2+) revealed a mutually competitive binding site common to three metal ions and a set of noncompetitive binding sites, including one Cd super(2+) site, one Hg super(2+) site, and at least one Zn super(2+) site, to which the binding of Zn super(2+) exhibited partial inhibitions of both Cd super(2+) and Hg super(2+) bindings. Lowering the pH from 7.0 to 5.5 inhibited binding of Zn super(2+) and Cd super(2+) to the common site. Further, the enthalpy change of the Cd super(2+) binding to the common site was found to be related linearly to the ionization enthalpy of the pH buffer with a slope corresponding to the release of 1.23 H super(+) for each Cd super(2+) binding. These H super(+) effects are consistent with a coupled deprotonation process upon binding of Zn super(2+) and Cd super(2+). Modification of histidine residues by diethyl pyrocarbonate specifically inhibited Zn super(2+) binding to the common binding site, indicating that the mechanism of binding-deprotonation coupling involves a histidine residue(s). JF - Journal of Biological Chemistry AU - Chao, Y AU - Fu, D AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, dax@bnl.gov Y1 - 2004/04/23/ PY - 2004 DA - 2004 Apr 23 SP - 17173 EP - 17180 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 279 IS - 17 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Membranes KW - Thermodynamics KW - Transport KW - Zinc KW - Escherichia coli KW - Mercury KW - Homeostasis KW - Copper KW - Mechanisms KW - Modification KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18048225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Thermodynamic+Studies+of+the+Mechanism+of+Metal+Binding+to+the+Escherichia+coli+Zinc+Transporter+YiiP&rft.au=Chao%2C+Y%3BFu%2C+D&rft.aulast=Chao&rft.aufirst=Y&rft.date=2004-04-23&rft.volume=279&rft.issue=17&rft.spage=17173&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M400208200 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Membranes; Thermodynamics; Transport; Zinc; Mercury; Copper; Homeostasis; Mechanisms; Modification; Escherichia coli DO - http://dx.doi.org/10.1074/jbc.M400208200 ER - TY - JOUR T1 - A second life in science--working after the age of 65. AN - 71723123; 15010320 AB - I was born in January, 1921 and was fortunate in working for a research organization that had no fixed retirement age. I was permitted to continue Science as long as there were some resources to support research that had some relevance to the organization's goals. A number of projects on which I worked were continuations of ones begun before the age of 65 (1986) and several new ones were based on both previous interests and ideas and some on new ideas. A number of the ideas arose from participation on Committees of the US National Research Council. I was able to extend my earlier interests in DNA repair to include experiments on the variations in DNA repair among apparently normal humans. In collaborations with other researchers we showed that the repair abilities following exposures to chemicals or to ionizing or ultraviolet (UV) radiation did not follow Poisson distributions. I participated in experiments, using a fish model to estimate the wavelength ranges in sunlight responsible for inducing melanoma and another fish model to estimate the germ cell mutations that might arise from exposures to the heavily ionizing particles in cosmic rays beyond low Earth orbit. A transgenic fish model was used to investigate the possibilities of using the fish to assay for mutagens in sediments in Long Island Sound. These Reflections summarize the atmosphere necessary for a second life and the scientific results of this life. JF - DNA repair AU - Setlow, Richard B AD - Biology Department, Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA. setlow@bnl.gov Y1 - 2004/04/01/ PY - 2004 DA - 2004 Apr 01 SP - 441 EP - 449 VL - 3 IS - 4 SN - 1568-7864, 1568-7864 KW - Index Medicus KW - United States KW - Animals KW - History, 20th Century KW - DNA Repair KW - Melanoma -- etiology KW - Humans KW - Neoplasms, Radiation-Induced KW - Radiation Tolerance KW - Aged KW - Biology KW - Employment -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71723123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=A+second+life+in+science--working+after+the+age+of+65.&rft.au=Setlow%2C+Richard+B&rft.aulast=Setlow&rft.aufirst=Richard&rft.date=2004-04-01&rft.volume=3&rft.issue=4&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-08 N1 - Date created - 2004-03-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Sunlight transmission through desert dust and marine aerosols; diffuse light corrections to Sun photometry and pyrheliometry AN - 51808679; 2004-064188 JF - Journal of Geophysical Research AU - Russell, P B AU - Livingston, J M AU - Dubovik, O AU - Ramirez, S A AU - Wang, J AU - Redemann, J AU - Schmid, B AU - Box, M AU - Holben, B N Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 13 PB - American Geophysical Union, Washington, DC VL - 109 IS - D8 SN - 0148-0227, 0148-0227 KW - terrestrial environment KW - clastic sediments KW - pyrheliometry KW - equations KW - photometry KW - optical properties KW - marine environment KW - mathematical methods KW - dust KW - solar radiation KW - sediments KW - aerosols KW - propagation KW - corrections KW - light KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51808679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Sunlight+transmission+through+desert+dust+and+marine+aerosols%3B+diffuse+light+corrections+to+Sun+photometry+and+pyrheliometry&rft.au=Russell%2C+P+B%3BLivingston%2C+J+M%3BDubovik%2C+O%3BRamirez%2C+S+A%3BWang%2C+J%3BRedemann%2C+J%3BSchmid%2C+B%3BBox%2C+M%3BHolben%2C+B+N&rft.aulast=Russell&rft.aufirst=P&rft.date=2004-04-01&rft.volume=109&rft.issue=D8&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2003JD004292 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 56 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - SuppNotes - Includes appendix N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aerosols; clastic sediments; corrections; dust; equations; light; marine environment; mathematical methods; optical properties; photometry; propagation; pyrheliometry; sediments; solar radiation; terrestrial environment DO - http://dx.doi.org/10.1029/2003JD004292 ER - TY - JOUR T1 - Kinetic Study of the Antiport Mechanism of an Escherichia coli Zinc Transporter, ZitB AN - 18035646; 5860678 AB - ZitB is a member of the cation diffusion facilitator (CDF) family that mediates efflux of zinc across the plasma membrane of Escherichia coli. We describe the first kinetic study of the purified and reconstituted ZitB by stopped-flow measurements of transmembrane fluxes of metal ions using a metal- sensitive fluorescent indicator encapsulated in proteoliposomes. Metal ion filling experiments showed that the initial rate of Zn super(2+) influx was a linear function of the molar ratio of ZitB to lipid and was related to the concentration of Zn super(2+) or Cd super(2+) by a hyperbola with a Michaelis-Menten constant (K sub(m)) of 104.9 plus or minus 5.4 mu M and 90.1 plus or minus 3.7 mu M, respectively. Depletion of proton stalled Cd super(2+) transport down its diffusion gradient, whereas tetraethylammonium ion substitution for K super(+) did not affect Cd super(2+) transport, indicating that Cd super(2+) transport is coupled to H super(+) rather than to K super(+). H super(+) transport was inferred by the H super(+) dependence of Cd super(2+) transport, showing a hyperbolic relationship with a K sub(m) of 19.9 nM for H super(+). Applying H super(+) diffusion gradients across the membrane caused Cd super(2+) fluxes both into and out of proteoliposomes against the imposed H super(+) gradients. Likewise, applying outwardly oriented membrane electrical potential resulted in Cd super(2+) efflux, demonstrating the electrogenic effect of ZitB transport. Taken together, these results indicate that ZitB is an antiporter catalyzing the obligatory exchange of Zn super(2+) or Cd super(2+) for H super(+). The exchange stoichiometry of metal ion for proton is likely to be 1:1. JF - Journal of Biological Chemistry AU - Chao, Y AU - Fu, D AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, dax@bnl.gov Y1 - 2004/03/26/ PY - 2004 DA - 2004 Mar 26 SP - 12043 EP - 12050 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 279 IS - 13 SN - 0021-9258, 0021-9258 KW - proteoliposomes KW - Microbiology Abstracts B: Bacteriology KW - Fluorescence KW - Metal ions KW - Depletion KW - Protons KW - Efflux KW - Lipids KW - Gradients KW - Encapsulation KW - Plasma membranes KW - Flux KW - Zinc KW - Escherichia coli KW - Stoichiometry KW - Tetraethylammonium KW - J 02721:Cell cycle, morphology and motility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18035646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Kinetic+Study+of+the+Antiport+Mechanism+of+an+Escherichia+coli+Zinc+Transporter%2C+ZitB&rft.au=Chao%2C+Y%3BFu%2C+D&rft.aulast=Chao&rft.aufirst=Y&rft.date=2004-03-26&rft.volume=279&rft.issue=13&rft.spage=12043&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M313510200 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Fluorescence; Metal ions; Protons; Depletion; Lipids; Efflux; Gradients; Encapsulation; Plasma membranes; Flux; Zinc; Stoichiometry; Tetraethylammonium; Escherichia coli DO - http://dx.doi.org/10.1074/jbc.M313510200 ER - TY - JOUR T1 - Role of metals in the biological activity of Clostridium botulinum neurotoxins. AN - 80181038; 14979717 AB - Clostridium botulinum neurotoxins are the most potent toxins to humans and cause paralysis by blocking neurotransmitter release at the presynaptic nerve terminals. The toxicity involves four steps, viz., binding to neuronal cells, internalization, translocation, and catalytic activity. While the catalytic activity is a zinc endopeptidase activity on the SNARE complex proteins, the translocation is believed to be a pH-dependent process allowing the translocation domain to change its conformation to penetrate the endosomal membrane. Here, we report the crystal structures of botulinum neurotoxin type B at various pHs and of an apo form of the neurotoxin, and discuss the role of metal ions and the effect of pH variation in the biological activity. Except for the perturbation of a few side chains, the conformation of the catalytic domain is unchanged in the zinc-depleted apotoxin, suggesting that zinc's role is catalytic. We have also identified two calcium ions in the molecule and present biochemical evidence to show that they play a role in the translocation of the light chain through the membrane. JF - Biochemistry AU - Eswaramoorthy, Subramaniam AU - Kumaran, Desigan AU - Keller, James AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2004/03/02/ PY - 2004 DA - 2004 Mar 02 SP - 2209 EP - 2216 VL - 43 IS - 8 SN - 0006-2960, 0006-2960 KW - Apoproteins KW - 0 KW - Cations, Divalent KW - Membrane Proteins KW - Metals, Heavy KW - Nerve Tissue Proteins KW - Snap25 protein, mouse KW - Synaptosomal-Associated Protein 25 KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Zinc KW - J41CSQ7QDS KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Protein Structure, Secondary KW - Apoproteins -- chemistry KW - Calcium -- chemistry KW - Hydrogen-Ion Concentration KW - Membrane Proteins -- metabolism KW - Catalytic Domain KW - Mice KW - Zinc -- chemistry KW - Binding Sites KW - Cells, Cultured KW - Nerve Tissue Proteins -- metabolism KW - Crystallography, X-Ray KW - Cytosol -- microbiology KW - Cations, Divalent -- chemistry KW - Protein Transport KW - Protein Conformation KW - Botulinum Toxins, Type A -- metabolism KW - Botulinum Toxins -- chemistry KW - Metals, Heavy -- chemistry KW - Botulinum Toxins -- metabolism KW - Botulinum Toxins, Type A -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80181038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Role+of+metals+in+the+biological+activity+of+Clostridium+botulinum+neurotoxins.&rft.au=Eswaramoorthy%2C+Subramaniam%3BKumaran%2C+Desigan%3BKeller%2C+James%3BSwaminathan%2C+Subramanyam&rft.aulast=Eswaramoorthy&rft.aufirst=Subramaniam&rft.date=2004-03-02&rft.volume=43&rft.issue=8&rft.spage=2209&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-06-29 N1 - Date created - 2004-02-24 N1 - Date revised - 2017-02-17 N1 - Genetic sequence - 1S0D; PDB; 1S0E; 1S0B; 1S0C; 1S0F; 1S0G N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Structure and enzymatic activity of botulinum neurotoxins. AN - 85376708; pmid-15027050 AB - The structure of botulinum neurotoxin type B (BoNT/B) is analyzed, and it is demonstrated that the carbonyl oxygen of the scissile bond comes close to the zinc ion to form a Michaelis complex. The hydrated carbonyl is activated by the nucleophilic water, which moves closer to Glu 230 to form hydrogen bonds to side-chain carboxylate. This process frees up the lone pair, which forms a bond with carbonyl carbon, corresponding to the tetrahedral transition state. The hydrated peptide oxygen is stabilized by a zinc ion and a water molecule close by. The proton from the nucleophile moves to NH of the scissile bond. The other proton is shuttled by Glu 230 to the NH2 group to make it NH3+ and allows it to leave. This mechanism is consistent with that proposed for thermolysin and BoNT/A. On the basis of these studies, we have shown that Tyr372 or Arg369 may not have any significant role in catalytic activity except for a secondary role such as stabilizing the transition state. Thus, the sulfate ion mimics the transition state of the scissile carbonyl carbon atom. However, the sulfate ion by itself does not inhibit the toxicity. JF - Movement disorders : official journal of the Movement Disorder Society AU - Swaminathan, Subramanyam AU - Eswaramoorthy, Subramanian AU - Kumaran, Desigan AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. swami@bnl.gov Y1 - 2004/03// PY - 2004 DA - Mar 2004 SP - S17 EP - S22 VL - 19 Suppl 8 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - *Botulinum Toxins: chemistry KW - *Botulinum Toxins: metabolism KW - Crystallography, X-Ray: methods KW - *Hydrogen Bonding KW - Molecular Structure KW - Protein Conformation KW - Structure-Activity Relationship KW - Zinc: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85376708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Structure+and+enzymatic+activity+of+botulinum+neurotoxins.&rft.au=Swaminathan%2C+Subramanyam%3BEswaramoorthy%2C+Subramanian%3BKumaran%2C+Desigan&rft.aulast=Swaminathan&rft.aufirst=Subramanyam&rft.date=2004-03-01&rft.volume=19+Suppl+8&rft.issue=&rft.spage=S17&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cloning, high level expression, purification, and crystallization of the full length Clostridium botulinum neurotoxin type E light chain. AN - 80152535; 14766304 AB - The catalytic activity of the highly potent botulinum neurotoxins are confined to their N-terminal light chains ( approximately 50kDa). A full-length light chain for the type E neurotoxin with a C-terminal 6x His-tag, BoNT/E-LC, has been cloned in a pET-9c vector and over-expressed in BL21 (DE3) cells. BoNT/E-LC was purified to homogeneity by affinity chromatography on Ni-NTA agarose followed by exclusion chromatography using a Superdex-75 sizing column. The purified protein has very good solubility and can be stored stably at -20 degrees C; however, it seems to undergo auto-proteolysis when stored at temperature #10878;4-10 degrees C. BoNT/E-LC is active on its natural substrate, the synaptosomal associated 25kDa protein, SNAP-25, indicating that it retains a native-like conformation and therefore can be considered as a useful tool in studying the structure/function of the catalytic light chain. Recombinant BoNT/E-LC has been crystallized under five different conditions and at various pHs. Crystals diffract to better than 2.1A. JF - Protein expression and purification AU - Agarwal, Rakhi AU - Eswaramoorthy, Subramaniam AU - Kumaran, Desigan AU - Dunn, John J AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 95 EP - 102 VL - 34 IS - 1 SN - 1046-5928, 1046-5928 KW - Membrane Proteins KW - 0 KW - Nerve Tissue Proteins KW - Protein Subunits KW - Recombinant Fusion Proteins KW - Synaptosomal-Associated Protein 25 KW - Histidine KW - 4QD397987E KW - Botulinum Toxins KW - EC 3.4.24.69 KW - botulinum toxin type E KW - T579M564JY KW - Index Medicus KW - Recombinant Fusion Proteins -- biosynthesis KW - Electrophoresis, Polyacrylamide Gel KW - Recombinant Fusion Proteins -- isolation & purification KW - Escherichia coli -- genetics KW - Nerve Tissue Proteins -- biosynthesis KW - Membrane Proteins -- genetics KW - Clostridium botulinum -- enzymology KW - Recombinant Fusion Proteins -- chemistry KW - Chromatography, Gel KW - Membrane Proteins -- biosynthesis KW - Time Factors KW - Crystallization KW - Solubility KW - Membrane Proteins -- metabolism KW - Temperature KW - Nerve Tissue Proteins -- genetics KW - Cloning, Molecular KW - Chromatography, Affinity KW - Histidine -- genetics KW - Enzyme Stability KW - Kinetics KW - Nerve Tissue Proteins -- metabolism KW - Genetic Vectors -- genetics KW - Clostridium botulinum -- genetics KW - Catalysis KW - Protein Subunits -- genetics KW - Gene Expression -- genetics KW - Protein Subunits -- biosynthesis KW - Botulinum Toxins -- genetics KW - Botulinum Toxins -- biosynthesis KW - Protein Subunits -- metabolism KW - Botulinum Toxins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80152535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+expression+and+purification&rft.atitle=Cloning%2C+high+level+expression%2C+purification%2C+and+crystallization+of+the+full+length+Clostridium+botulinum+neurotoxin+type+E+light+chain.&rft.au=Agarwal%2C+Rakhi%3BEswaramoorthy%2C+Subramaniam%3BKumaran%2C+Desigan%3BDunn%2C+John+J%3BSwaminathan%2C+Subramanyam&rft.aulast=Agarwal&rft.aufirst=Rakhi&rft.date=2004-03-01&rft.volume=34&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Protein+expression+and+purification&rft.issn=10465928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-26 N1 - Date created - 2004-02-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Hydrolase activity, microbial biomass and community structure in long-term Cd-contaminated soils AN - 51828909; 2004-051259 JF - Soil Biology & Biochemistry AU - Renella, G AU - Mench, M AU - van der Lelie, D AU - Pietramellara, G AU - Ascher, J AU - Ceccherini, M T AU - Landi, L AU - Nannipieri, P Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 443 EP - 451 PB - Pergamon, Oxford VL - 36 IS - 3 SN - 0038-0717, 0038-0717 KW - soils KW - concentration KW - toxic materials KW - yields KW - biomass KW - pollutants KW - metabolism KW - electrophoresis KW - pollution KW - bioavailability KW - solubility KW - hydrolases KW - habitat KW - detection KW - metals KW - bacteria KW - cadmium KW - land use KW - activity KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51828909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+Biology+%26+Biochemistry&rft.atitle=Hydrolase+activity%2C+microbial+biomass+and+community+structure+in+long-term+Cd-contaminated+soils&rft.au=Renella%2C+G%3BMench%2C+M%3Bvan+der+Lelie%2C+D%3BPietramellara%2C+G%3BAscher%2C+J%3BCeccherini%2C+M+T%3BLandi%2C+L%3BNannipieri%2C+P&rft.aulast=Renella&rft.aufirst=G&rft.date=2004-03-01&rft.volume=36&rft.issue=3&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Soil+Biology+%26+Biochemistry&rft.issn=00380717&rft_id=info:doi/10.1016%2Fj.soilbio.2003.10.022 L2 - http://www.sciencedirect.com/science/journal/00380717 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 51 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - activity; bacteria; bioavailability; biomass; cadmium; concentration; detection; electrophoresis; habitat; hydrolases; land use; metabolism; metals; microorganisms; pollutants; pollution; soils; solubility; toxic materials; yields DO - http://dx.doi.org/10.1016/j.soilbio.2003.10.022 ER - TY - JOUR T1 - Ancient water on 4 Vesta Asteroid; evidence from a quartz veinlet in the Serra de Mage eucrite meteorite AN - 50272064; 2005-071173 AB - The meteorite Serra de Mage, a eucrite inferred to be from the asteroid 4 Vesta, contains quartz veinlets. They are identical to antitaxial or "crack-seal" quartz veinlets in terrestrial rocks, and are extraterrestrial and ancient because they pre-date a 4.40 Ga metamorphism. The quartz was likely deposited from liquid water solutions (as are terrestrial veins); other potential solvents or transport mechanisms are inadequate or unlikely. Because there is no indication of internal (magmatic) water in the eucrite meteorites and thus in Vesta, the water from which the veinlet was deposited probably came from outside Vesta. By analogy with water ice deposits on the Moon and Mercury, Vesta and similar asteroids may have had (or now have) polar ice deposits, possibly derived from comet impacts. JF - Earth and Planetary Science Letters AU - Treiman, Allan H AU - Lanzirotti, Antonio AU - Xirouchakis, Dimitrios Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 189 EP - 199 PB - Elsevier, Amsterdam VL - 219 IS - 3-4 SN - 0012-821X, 0012-821X KW - silicates KW - stony meteorites KW - asteroids KW - X-ray diffraction data KW - electron probe data KW - meteorites KW - mineral composition KW - ice KW - Mercury Planet KW - Archean KW - chemical composition KW - geochemistry KW - Precambrian KW - Vesta Asteroid KW - Moon KW - textures KW - cosmochemistry KW - impacts KW - veins KW - metamorphism KW - achondrites KW - terrestrial planets KW - quartz veins KW - planets KW - Serra de Mage Meteorite KW - comets KW - petrography KW - eucrite KW - 05B:Petrology of meteorites and tektites KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50272064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Earth+and+Planetary+Science+Letters&rft.atitle=Ancient+water+on+4+Vesta+Asteroid%3B+evidence+from+a+quartz+veinlet+in+the+Serra+de+Mage+eucrite+meteorite&rft.au=Treiman%2C+Allan+H%3BLanzirotti%2C+Antonio%3BXirouchakis%2C+Dimitrios&rft.aulast=Treiman&rft.aufirst=Allan&rft.date=2004-03-01&rft.volume=219&rft.issue=3-4&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Earth+and+Planetary+Science+Letters&rft.issn=0012821X&rft_id=info:doi/10.1016%2FS0012-821X%2804%2900004-4 L2 - http://www.sciencedirect.com/science/journal/0012821X LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 50 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - EPSLA2 N1 - SubjectsTermNotLitGenreText - achondrites; Archean; asteroids; chemical composition; comets; cosmochemistry; electron probe data; eucrite; geochemistry; ice; impacts; Mercury Planet; metamorphism; meteorites; mineral composition; Moon; petrography; planets; Precambrian; quartz veins; Serra de Mage Meteorite; silicates; stony meteorites; terrestrial planets; textures; veins; Vesta Asteroid; X-ray diffraction data DO - http://dx.doi.org/10.1016/S0012-821X(04)00004-4 ER - TY - JOUR T1 - A NRC-BNL benchmark evaluation of seismic analysis methods for non-classically damped coupled systems AN - 17994455; 5934753 AB - Under the auspices of the U.S. Nuclear Regulatory Commission (NRC), Brookhaven National Laboratory (BNL) developed a comprehensive program to evaluate state-of-the-art methods and computer programs for seismic analysis of typical coupled nuclear power plant (NPP) systems with non-classical damping. In this program, four benchmark models of coupled building-piping/equipment systems with different damping characteristics were developed and analyzed by BNL for a suite of earthquakes. The BNL analysis was carried out by the Wilson- theta time domain integration method with the system-damping matrix computed using a synthesis formulation as presented in a companion paper [Nucl. Eng. Des. (2002)]. These benchmark problems were subsequently distributed to and analyzed by program participants applying their uniquely developed methods and computer programs. This paper is intended to offer a glimpse at the program, and provide a summary of major findings and principle conclusions with some representative results. The participant's analysis results established using complex modal time history methods showed good comparison with the BNL solutions, while the analyses produced with either complex-mode response spectrum methods or classical normal-mode response spectrum method, in general, produced more conservative results, when averaged over a suite of earthquakes. However, when coupling due to damping is significant, complex-mode response spectrum methods performed better than the classical normal-mode response spectrum method. Furthermore, as part of the program objectives, a parametric assessment is also presented in this paper, aimed at evaluation of the applicability of various analysis methods to problems with different dynamic characteristics unique to coupled NPP systems. It is believed that the findings and insights learned from this program will be useful in developing new acceptance criteria and providing guidance for future regulatory activities involving license applications of these alternate methods to coupled systems. JF - Nuclear Engineering and Design AU - Xu, J AU - DeGrassi, G AU - Chokshi, N AD - Brookhaven National Laboratory, Upton, NY 11973-5000, USA Y1 - 2004/03// PY - 2004 DA - Mar 2004 SP - 345 EP - 366 VL - 228 IS - 1-3 SN - 0029-5493, 0029-5493 KW - damping KW - Health & Safety Science Abstracts KW - Earthquakes KW - Nuclear power plants KW - Structural analysis KW - Seismic activity KW - Computer applications KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17994455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Engineering+and+Design&rft.atitle=A+NRC-BNL+benchmark+evaluation+of+seismic+analysis+methods+for+non-classically+damped+coupled+systems&rft.au=Xu%2C+J%3BDeGrassi%2C+G%3BChokshi%2C+N&rft.aulast=Xu&rft.aufirst=J&rft.date=2004-03-01&rft.volume=228&rft.issue=1-3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Nuclear+Engineering+and+Design&rft.issn=00295493&rft_id=info:doi/10.1016%2Fj.nucengdes.2003.06.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Computer applications; Structural analysis; Nuclear power plants; Earthquakes; Seismic activity DO - http://dx.doi.org/10.1016/j.nucengdes.2003.06.019 ER - TY - JOUR T1 - Degradation assessment of structures and passive components at nuclear power plants AN - 17986258; 5934750 AB - This paper describes a multi-year research program to assess age-related degradation of structures and passive components important to the safe operation of nuclear power plants (NPPs). The purpose of the research effort is to develop the technical basis for the validation and improvement of analytical methods and acceptance criteria which can be used to make risk-informed decisions and to address technical issues related to degradation of structures and passive components. The approach adopted for this research program consists of two phases. In Phase I, specific degradation occurrences at plants were collected and evaluated, existing technical information on aging was reviewed, and a scoping study was performed to identify which structures and components should be studied in the subsequent phases of the research program. Based on the results of the Phase I effort, selected structures and passive components are evaluated in Phase II to assess the effects of age-related degradation using existing and enhanced analytical methods. Fragility analyses are performed for undegraded and degraded structures and passive components. These results can then be used to assess the potential impact of degradation on overall plant risk. The Phase II effort also utilizes the results of the analyses to develop probabilistic degradation acceptance criteria for the structures and passive components studied. These research activities provide useful tools to support the current goals of developing risk-informed and performance-based regulation in the nuclear industry. JF - Nuclear Engineering and Design AU - Braverman, JI AU - Miller, CA AU - Hofmayer, CH AU - Ellingwood, B R AU - Naus, D J AU - Chang, TY AD - Brookhaven National Laboratory, Building 130, P.O. Box 5000, Upton, NY, USA Y1 - 2004/03// PY - 2004 DA - Mar 2004 SP - 283 EP - 304 VL - 228 IS - 1-3 SN - 0029-5493, 0029-5493 KW - Health & Safety Science Abstracts; Risk Abstracts KW - decision making KW - Nuclear power plants KW - service life KW - aging KW - R2 23020:Technological risks KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17986258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Engineering+and+Design&rft.atitle=Degradation+assessment+of+structures+and+passive+components+at+nuclear+power+plants&rft.au=Braverman%2C+JI%3BMiller%2C+CA%3BHofmayer%2C+CH%3BEllingwood%2C+B+R%3BNaus%2C+D+J%3BChang%2C+TY&rft.aulast=Braverman&rft.aufirst=JI&rft.date=2004-03-01&rft.volume=228&rft.issue=1-3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Nuclear+Engineering+and+Design&rft.issn=00295493&rft_id=info:doi/10.1016%2Fj.nucengdes.2003.06.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - aging; service life; Nuclear power plants; decision making DO - http://dx.doi.org/10.1016/j.nucengdes.2003.06.012 ER - TY - JOUR T1 - Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence. AN - 80140719; 14754772 AB - OBJECTIVEMethamphetamine is a highly addictive drug of abuse that is neurotoxic to dopamine terminals. The authors recently reported that decreases in dopamine transporters (used as markers of dopamine terminals) in the striatum of methamphetamine abusers recover with protracted abstinence and that relative to comparison subjects, recently detoxified methamphetamine abusers have lower metabolism in the striatum and thalamus. In this study, the authors assessed whether metabolism recovers with protracted abstinence.METHODBrain glucose metabolism was measured with positron emission tomography and [18F]fluorodeoxyglucose in five methamphetamine abusers who were evaluated after both a short (<6 months) and protracted (12-17 months) abstinence interval, eight methamphetamine abusers tested only after protracted abstinence, and 11 comparison subjects who were not drug users.RESULTSSignificantly greater thalamic, but not striatal, metabolism was seen following protracted abstinence relative to metabolism assessed after a short abstinence interval, and this increase was associated with improved performance in motor and verbal memory tests. Relative to the comparison subjects, the methamphetamine abusers tested after protracted abstinence had lower metabolism in the striatum (most accentuated in the caudate and nucleus accumbens) but not in the thalamus.CONCLUSIONSThe persistent decreases in striatal metabolism in methamphetamine abusers could reflect long-lasting changes in dopamine cell activity, and decreases in the nucleus accumbens could account for the persistence of amotivation and anhedonia in detoxified methamphetamine abusers. The recovery of thalamic metabolism could reflect adaptation responses to compensate for the dopamine deficits, and the associated improvement in neuropsychological performance further indicates its functional significance. These results suggest that while protracted abstinence may reverse some of the methamphetamine-induced alterations in brain function, other deficits persist. JF - The American journal of psychiatry AU - Wang, Gene-Jack AU - Volkow, Nora D AU - Chang, Linda AU - Miller, Eric AU - Sedler, Mark AU - Hitzemann, Robert AU - Zhu, Wei AU - Logan, Jean AU - Ma, Yeming AU - Fowler, Joanna S AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. gjwang@bnl.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 242 EP - 248 VL - 161 IS - 2 SN - 0002-953X, 0002-953X KW - Radiopharmaceuticals KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Cognition Disorders -- diagnosis KW - Corpus Striatum -- metabolism KW - Humans KW - Thalamus -- metabolism KW - Corpus Striatum -- physiopathology KW - Adult KW - Tomography, Emission-Computed KW - Thalamus -- physiopathology KW - Adaptation, Physiological KW - Neuropsychological Tests KW - Time Factors KW - Female KW - Male KW - Brain -- physiopathology KW - Amphetamine-Related Disorders -- prevention & control KW - Amphetamine-Related Disorders -- metabolism KW - Recovery of Function KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Presynaptic Terminals -- metabolism KW - Amphetamine-Related Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80140719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Partial+recovery+of+brain+metabolism+in+methamphetamine+abusers+after+protracted+abstinence.&rft.au=Wang%2C+Gene-Jack%3BVolkow%2C+Nora+D%3BChang%2C+Linda%3BMiller%2C+Eric%3BSedler%2C+Mark%3BHitzemann%2C+Robert%3BZhu%2C+Wei%3BLogan%2C+Jean%3BMa%2C+Yeming%3BFowler%2C+Joanna+S&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2004-02-01&rft.volume=161&rft.issue=2&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-01 N1 - Date created - 2004-02-02 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: Am J Psychiatry. 2004 Feb;161(2):193-4 [14754764] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Anisotropic compression of edingtonite and thomsonite to 6 GPa at room temperature AN - 51499569; 2007-007280 JF - Physics and Chemistry of Minerals AU - Lee, Y AU - Hriljac, J A AU - Studer, A AU - Vogt, T Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 22 EP - 27 PB - Springer-Verlag, Berlin - New York VL - 31 IS - 1 SN - 0342-1791, 0342-1791 KW - silicates KW - pressure KW - X-ray diffraction data KW - statistical analysis KW - unit cell KW - crystal structure KW - elastic constants KW - edingtonite KW - bulk modulus KW - high pressure KW - least-squares analysis KW - thomsonite KW - zeolite group KW - framework silicates KW - compression KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51499569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+and+Chemistry+of+Minerals&rft.atitle=Anisotropic+compression+of+edingtonite+and+thomsonite+to+6+GPa+at+room+temperature&rft.au=Lee%2C+Y%3BHriljac%2C+J+A%3BStuder%2C+A%3BVogt%2C+T&rft.aulast=Lee&rft.aufirst=Y&rft.date=2004-02-01&rft.volume=31&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Physics+and+Chemistry+of+Minerals&rft.issn=03421791&rft_id=info:doi/10.1007%2Fs00269-003-0330-6 L2 - http://www.springerlink.com/content/100449/?p=e597e977f1914094b3810f7e67f0a453&pi=0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 31 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PCMIDU N1 - SubjectsTermNotLitGenreText - bulk modulus; compression; crystal structure; edingtonite; elastic constants; framework silicates; high pressure; least-squares analysis; pressure; silicates; statistical analysis; thomsonite; unit cell; X-ray diffraction data; zeolite group DO - http://dx.doi.org/10.1007/s00269-003-0330-6 ER - TY - JOUR T1 - Steroids in sediments from Zabuye salt lake, western Tibet; diagenetic, ecological or climatic signals? AN - 50293834; 2004-056164 AB - A 45 cm long core from Zabuye Salt Lake (Tibetan Plateau, S.W China) was studied to reveal the possible interference between diagenesis and climate signals. Steroids, including sterols and sterenes, dominate the soluble organic matter in these cores. The relative abundance of C (sub 27) sterol to the C (sub 29) sterols decreases with depth, resulting in a predominance of C (sub 29) sterols at the bottom section of this core. This change in the relative molecular distribution could be attributed to both environmental/ecological change and diagenetic complication of molecular signals. Sterols in the shallow sediments are relatively enriched in (super 13) C compared to those from lower within the core. This enrichment is possibly associated either with environmental/climatic change (e.g., increase of salinity and global pCO (sub 2) level change etc.) or it could be attributed to the biogeochemical change of organic matter during early diagenesis. 4,4-dimethyl spirosterenes and their possible precursors, 4,4-dimethyl sterenes, constitute a major component of the apolar fraction of organic matter. delta (super 13) C values of the 4,4-dimethyl sterenes indicate that they are derived from phytoplanktonic algae rather than from bacteria. The delta (super 13) C values of the regular and spiro steroids differ by >2 per mil suggesting either backbone arrangement of steroids might have involved isotopic fractionation or that these steroids are derived separately from different biological sources. JF - Organic Geochemistry AU - Wang, R L AU - Brassell, S C AU - Scarpitta, S C AU - Zheng, M P AU - Zhang, S C AU - Hayde, P R AU - Muench, L M Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 157 EP - 168 PB - Pergamon, Oxford-New York VL - 35 IS - 2 SN - 0146-6380, 0146-6380 KW - Far East KW - isotopes KW - mass spectra KW - steroids KW - bonding KW - salinity KW - environmental analysis KW - stable isotopes KW - cores KW - climate change KW - carbon dioxide KW - gas chromatography KW - sampling KW - Xizang China KW - carbon KW - Tibetan Plateau KW - sediments KW - ecology KW - spectra KW - chemical composition KW - Asia KW - geochemistry KW - climate KW - China KW - salt lakes KW - isotope ratios KW - C-13/C-12 KW - sedimentation KW - molecular structure KW - organic compounds KW - Zabuye Lake KW - diagenesis KW - bacteria KW - lacustrine environment KW - microorganisms KW - lake sediments KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50293834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+Geochemistry&rft.atitle=Steroids+in+sediments+from+Zabuye+salt+lake%2C+western+Tibet%3B+diagenetic%2C+ecological+or+climatic+signals%3F&rft.au=Wang%2C+R+L%3BBrassell%2C+S+C%3BScarpitta%2C+S+C%3BZheng%2C+M+P%3BZhang%2C+S+C%3BHayde%2C+P+R%3BMuench%2C+L+M&rft.aulast=Wang&rft.aufirst=R&rft.date=2004-02-01&rft.volume=35&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Organic+Geochemistry&rft.issn=01466380&rft_id=info:doi/10.1016%2Fj.orggeochem.2003.10.003 L2 - http://www.sciencedirect.com/science/journal/01466380 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2004-01-01 N1 - Number of references - 34 N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; bacteria; bonding; C-13/C-12; carbon; carbon dioxide; chemical composition; China; climate; climate change; cores; diagenesis; ecology; environmental analysis; Far East; gas chromatography; geochemistry; isotope ratios; isotopes; lacustrine environment; lake sediments; mass spectra; microorganisms; molecular structure; organic compounds; salinity; salt lakes; sampling; sedimentation; sediments; spectra; stable isotopes; steroids; Tibetan Plateau; Xizang China; Zabuye Lake DO - http://dx.doi.org/10.1016/j.orggeochem.2003.10.003 ER - TY - JOUR T1 - Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells. AN - 66988419; 15494449 AB - Clustered DNA damages--two or more lesions on opposing strands and within one or two helical turns--are formed in cells by ionizing radiation or radiomimetic antitumor drugs. They are hypothesized to be difficult to repair, and thus are critical biological damages. Since individual abasic sites can be cytotoxic or mutagenic, abasic DNA clusters are likely to have significant cellular impact. Using a novel approach for distinguishing abasic clusters that are very closely spaced (putrescine cleavage) or less closely spaced (Nfo protein cleavage), we measured induction and processing of abasic clusters in 28SC human monocytes that were exposed to ionizing radiation. gamma-rays induced approximately 1 double-strand break: 1.3 putrescine-detected abasic clusters: 0.8 Nfo-detected abasic clusters. After irradiation, the 28SC cells rejoined double-strand breaks efficiently within 24 h. In contrast, in these cells, the levels of abasic clusters decreased very slowly over 14 days to background levels. In vitro repair experiments that used 28SC cell extracts further support the idea of slow processing of specific, closely spaced abasic clusters. Although some clusters were removed by active cellular repair, a substantial number was apparently decreased by 'splitting' during DNA replication and subsequent cell division. The existence of abasic clusters in 28SC monocytes, several days after irradiation suggests that they constitute persistent damages that could lead to mutation or cell killing. JF - Nucleic acids research AU - Georgakilas, Alexandros G AU - Bennett, Paula V AU - Wilson, David M AU - Sutherland, Betsy M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2004 PY - 2004 DA - 2004 SP - 5609 EP - 5620 VL - 32 IS - 18 KW - Escherichia coli Proteins KW - 0 KW - Deoxyribonuclease IV (Phage T4-Induced) KW - EC 3.1.21.2 KW - endonuclease IV, E coli KW - Putrescine KW - V10TVZ52E4 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Escherichia coli Proteins -- metabolism KW - Monocytes -- radiation effects KW - Humans KW - Monocytes -- metabolism KW - Putrescine -- metabolism KW - Cell Line KW - Deoxyribonuclease IV (Phage T4-Induced) -- metabolism KW - DNA Repair KW - Gamma Rays KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66988419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Processing+of+bistranded+abasic+DNA+clusters+in+gamma-irradiated+human+hematopoietic+cells.&rft.au=Georgakilas%2C+Alexandros+G%3BBennett%2C+Paula+V%3BWilson%2C+David+M%3BSutherland%2C+Betsy+M&rft.aulast=Georgakilas&rft.aufirst=Alexandros&rft.date=2004-01-01&rft.volume=32&rft.issue=18&rft.spage=5609&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-02 N1 - Date created - 2004-10-20 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Jun;41(6):671-6 [6288603] Mutat Res. 2003 Oct 29;531(1-2):93-107 [14637248] Photodermatol. 1985 Jun;2(3):186-91 [4022820] Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):103-8 [10618378] Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):686-91 [10639140] J Biol Chem. 2000 Feb 25;275(8):5323-8 [10681505] J Biol Chem. 2000 Mar 31;275(13):9390-5 [10734083] Annu Rev Biochem. 1999;68:255-85 [10872450] Electrophoresis. 2001 Mar;22(5):843-54 [11332751] Nucleic Acids Res. 2001 Jun 15;29(12):2558-66 [11410664] Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7426-30 [11404468] Mutat Res. 2001 May 10;485(4):283-307 [11585362] Biochemistry. 2001 Nov 6;40(44):13254-61 [11683634] Biochemistry. 2002 Jan 15;41(2):634-42 [11781104] Radiat Res. 2002 Jun;157(6):611-6 [12005538] Nucleic Acids Res. 2002 Jul 1;30(13):2800-8 [12087163] Free Radic Biol Med. 2004 Aug 15;37(4):488-99 [15256220] DNA Repair (Amst). 2004 Oct 5;3(10):1323-34 [15336627] Biochemistry. 1972 Sep 12;11(19):3618-23 [4559796] J Bacteriol. 1975 Feb;121(2):511-7 [1089633] Proc Natl Acad Sci U S A. 1976 Mar;73(3):809-12 [1062792] J Biol Chem. 1977 May 10;252(9):2808-14 [16002] Radiat Res. 1981 May;86(2):185-95 [7015409] Biochemistry. 1988 May 17;27(10):3850-7 [2457392] Biochem J. 1988 Jul 15;253(2):553-9 [2460081] Annu Rev Immunol. 1992;10:267-93 [1590988] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6601-5 [8341674] Int J Radiat Biol. 1994 Jan;65(1):7-17 [7905912] Nucleic Acids Res. 1994 Jun 11;22(11):2010-5 [7518077] J Biol Chem. 1995 Jul 7;270(27):16002-7 [7608159] J Biol Chem. 1997 Jun 20;272(25):15650-5 [9188454] EMBO J. 1997 Jun 2;16(11):3341-8 [9214649] Oncogene. 1997 Nov 20;15(21):2597-607 [9399647] Nucleic Acids Res. 1998 Jun 1;26(11):2771-8 [9592167] Cancer Res. 1999 Jan 1;59(1):14-8 [9892176] Mol Cell. 1999 Jan;3(1):33-42 [10024877] Cancer Res. 1999 Jun 1;59(11):2522-6 [10363965] J Mol Biol. 1999 Jul 16;290(3):667-84 [10395822] Nucleic Acids Res. 2002 Aug 1;30(15):3464-72 [12140332] Mutat Res. 2002 Nov 30;509(1-2):23-34 [12427529] Mol Cell Biol. 2003 Jan;23(1):382-8 [12482989] Oncogene. 2002 Dec 16;21(58):8926-34 [12483509] J Biol Chem. 2003 Mar 14;278(11):9378-81 [12519757] J Biol Chem. 2003 Mar 14;278(11):9005-12 [12519758] Nucleic Acids Res. 1982 Oct 25;10(20):6305-18 [6294597] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review. AN - 66712426; 15256343 AB - Overeating in obese individuals shares similarities with the loss of control and compulsive drug taking behavior observed in drug-addicted subjects. The mechanism of these behaviors is not well understood. Our prior studies with positron emission tomography (PET) in drug-addicted subjects documented reductions in striatal dopamine (DA) D2 receptors. In pathologically obese subjects, we found reductions in striatal DA D2 receptors similar to that in drug-addicted subjects. Moreover, DA D2 receptor levels were found to have an inverse relationship to the body mass index of the obese subjects. We postulated that decreased levels of DA D2 receptors predisposed subjects to search for reinforcers; in the case of drug-addicted subjects for the drug and in the case of the obese subjects for food as a means to temporarily compensate for a decreased sensitivity of DA D2 regulated reward circuits. Understanding the mechanism in food intake will help to suggest strategies for the treatment of obesity. JF - Journal of addictive diseases AU - Wang, Gene-Jack AU - Volkow, Nora D AU - Thanos, Panayotis K AU - Fowler, Joanna S AD - Medical Department, Brookhaven National Laboratory, PO Box 5000, Upton, NY 11973, USA. gjwang@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 39 EP - 53 VL - 23 IS - 3 SN - 1055-0887, 1055-0887 KW - Receptors, Dopamine D2 KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Methamphetamine -- metabolism KW - Humans KW - Cocaine -- metabolism KW - Receptors, Dopamine D2 -- metabolism KW - Substance-Related Disorders -- diagnosis KW - Obesity -- diagnosis KW - Obesity -- metabolism KW - Positron-Emission Tomography KW - Brain -- metabolism KW - Substance-Related Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66712426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Similarity+between+obesity+and+drug+addiction+as+assessed+by+neurofunctional+imaging%3A+a+concept+review.&rft.au=Wang%2C+Gene-Jack%3BVolkow%2C+Nora+D%3BThanos%2C+Panayotis+K%3BFowler%2C+Joanna+S&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2004-01-01&rft.volume=23&rft.issue=3&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-19 N1 - Date created - 2004-07-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex. AN - 66699103; 15246283 AB - We used exploratory and confirmatory statistical approaches to study the severity of neuropsychological (NP) impairment in 42 crack/cocaine addicted subjects and in 112 comparison subjects (40 alcoholics and 72 controls). Twenty neuropsychological test indices most reliably defining predetermined cognitive domains were submitted to exploratory factor analysis. A four-dimensional model of neurocognitive function was derived: Verbal Knowledge, Visual Memory, Verbal Memory, and Attention/Executive functioning accounted for 63% of the variance. We then examined this model's association with resting glucose metabolism in the brain reward circuit measured with 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography. Results revealed that (1) cocaine addicted individuals had a generalized mild level of neurocognitive impairment (<1 S.D. below control mean); and (2) controlling for age and education, relative metabolism in the dorsolateral prefrontal cortex significantly predicted the Visual Memory and Verbal Memory factors and relative metabolism in the anterior cingulate gyrus significantly predicted the Attention/Executive factor. Nevertheless, it remains to be determined whether metabolic changes in these regions are associated with addiction. Our results also suggest that compared to cocaine, alcohol has a more detrimental effect on Attention/Executive functioning, as assessed with traditional NP measures. We conclude that relative to other psychopathological disorders (such as schizophrenia), the severity of neuropsychological impairment in cocaine addiction is modest, albeit not indicative of the absence of neurocognitive dysfunction. The impact of such small differences in performance on quality of life, and possibly on craving and relapse, may be substantial. Tasks that simulate real-life decision-making or that target specific putative cognitive-behavioral or motivational-emotional mechanisms might offer greater sensitivity in characterizing the changes that accompany addiction to drugs. Obtaining valid estimates of alcohol use in cocaine addicted subjects is essential in characterizing neurocognitive functioning in individuals addicted to drugs. JF - Neuropsychologia AU - Goldstein, Rita Z AU - Leskovjan, Andreana C AU - Hoff, Anne L AU - Hitzemann, Robert AU - Bashan, Francine AU - Khalsa, Sahib Singh AU - Wang, Gene-Jack AU - Fowler, Joanna S AU - Volkow, Nora D AD - Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973-5000, USA. rgoldstein@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 1447 EP - 1458 VL - 42 IS - 11 SN - 0028-3932, 0028-3932 KW - Blood Glucose KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Index Medicus KW - Nerve Net -- diagnostic imaging KW - Blood Glucose -- metabolism KW - Gyrus Cinguli -- diagnostic imaging KW - Humans KW - Psychometrics -- statistics & numerical data KW - Models, Statistical KW - Gyrus Cinguli -- drug effects KW - Brain Mapping KW - Reward KW - Adult KW - Nerve Net -- drug effects KW - Middle Aged KW - Female KW - Male KW - Prefrontal Cortex -- diagnostic imaging KW - Neuropsychological Tests -- statistics & numerical data KW - Alcoholism -- rehabilitation KW - Alcoholism -- diagnostic imaging KW - Energy Metabolism -- drug effects KW - Tomography, Emission-Computed KW - Prefrontal Cortex -- drug effects KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66699103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychologia&rft.atitle=Severity+of+neuropsychological+impairment+in+cocaine+and+alcohol+addiction%3A+association+with+metabolism+in+the+prefrontal+cortex.&rft.au=Goldstein%2C+Rita+Z%3BLeskovjan%2C+Andreana+C%3BHoff%2C+Anne+L%3BHitzemann%2C+Robert%3BBashan%2C+Francine%3BKhalsa%2C+Sahib+Singh%3BWang%2C+Gene-Jack%3BFowler%2C+Joanna+S%3BVolkow%2C+Nora+D&rft.aulast=Goldstein&rft.aufirst=Rita&rft.date=2004-01-01&rft.volume=42&rft.issue=11&rft.spage=1447&rft.isbn=&rft.btitle=&rft.title=Neuropsychologia&rft.issn=00283932&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-17 N1 - Date created - 2004-07-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Deployment of a colloidal silica barrier at Brookhaven National Laboratory AN - 51781248; 2004-072457 AB - A colloidal silica (CS) barrier was deployed at Brookhaven National Laboratory (BNL) on Long Island, New York. Contamination including tritium ( (super 3) H) and sodium-22 ( (super 22) Na) was detected downgradient of the Brookhaven Linear Accelerator Isotope Producer (BLIP) during routine groundwater monitoring. An investigation was performed to confirm the BLIP was the source of the groundwater contamination and to determine the extent of the contamination. (CDM 1999) BNL then completed an Engineering Evaluation and Cost Analysis for the remediation/containment of the contaminated soils. The analysis recommended the emplacement of a CS barrier to encapsulate the contaminated soils beneath the BLIP building to prevent further migration of the contaminants to the groundwater. The CS barrier was emplaced in 2000 via downstage permeation grouting. The grout was injected from approximately 6 meters below ground surface (bgs) down to 10 meters bgs, encapsulating approximately 73 cubic meters of contaminated soil. In situ permeameter testing was conducted on a test panel adjacent to the barrier, so the integrity of the barrier would not be compromised. Using the measurements from the field permeameter testing and correlations previously developed from modeling and laboratory sand tank testing, it was determined that the flux through the test panel (and thus the barrier) met the BNL requirement. JF - Proceedings of the Symposium on Engineering Geology and Geotechnical Engineering AU - North-Abbott, Mary A AU - Manchester, Kenneth R AU - Trudnowski, John AU - Moe, Martin AU - Bickford, Jody AU - Zaluski, Marek H AU - Heiser, John H A2 - MacLaughlin, Mary M. A2 - McNearny, Richard L. Y1 - 2004 PY - 2004 DA - 2004 SP - 65 EP - 68 PB - [publisher varies], [location varies] VL - 39 KW - United States KW - colloidal materials KW - monitoring KW - isotopes KW - Brookhaven National Laboratory KW - alkali metals KW - waste disposal sites KW - pollution KW - tritium KW - sodium KW - ground water KW - Suffolk County New York KW - New York KW - radioactive isotopes KW - metals KW - infiltration KW - hydrogen KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51781248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Symposium+on+Engineering+Geology+and+Geotechnical+Engineering&rft.atitle=Deployment+of+a+colloidal+silica+barrier+at+Brookhaven+National+Laboratory&rft.au=North-Abbott%2C+Mary+A%3BManchester%2C+Kenneth+R%3BTrudnowski%2C+John%3BMoe%2C+Martin%3BBickford%2C+Jody%3BZaluski%2C+Marek+H%3BHeiser%2C+John+H&rft.aulast=North-Abbott&rft.aufirst=Mary&rft.date=2004-01-01&rft.volume=39&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Symposium+on+Engineering+Geology+and+Geotechnical+Engineering&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 39th symposium on Engineering geology and geotechnical engineering N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 3 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02957 N1 - SubjectsTermNotLitGenreText - alkali metals; Brookhaven National Laboratory; colloidal materials; ground water; hydrogen; infiltration; isotopes; metals; monitoring; New York; pollution; radioactive isotopes; sodium; Suffolk County New York; tritium; United States; waste disposal sites ER - TY - JOUR T1 - Synchrotron X-ray diffraction analysis of meteorites in thin section; preliminary results AN - 50540351; 2009-009387 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Treiman, A H AU - Lanzirotti, A AU - Xirouchakis, D AU - Anonymous Y1 - 2004 PY - 2004 DA - 2004 EP - unpaginated PB - Lunar and Planetary Science Conference, Houston, TX VL - 35 KW - silicates KW - Yamato Meteorites KW - chemical analysis KW - stony meteorites KW - iddingsite KW - X-ray diffraction data KW - Lafayette Meteorite KW - smectite KW - thin sections KW - synchrotron X-ray diffraction analysis KW - achondrites KW - clay minerals KW - meteorites KW - Serra de Mage Meteorite KW - Y 000749 KW - mineral composition KW - silica KW - eucrite KW - synchrotrons KW - sheet silicates KW - 05B:Petrology of meteorites and tektites KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50540351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Synchrotron+X-ray+diffraction+analysis+of+meteorites+in+thin+section%3B+preliminary+results&rft.au=Treiman%2C+A+H%3BLanzirotti%2C+A%3BXirouchakis%2C+D%3BAnonymous&rft.aulast=Treiman&rft.aufirst=A&rft.date=2004-01-01&rft.volume=35&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.lpi.usra.edu/meetings/lpsc2004/pdf/1172.pdf LA - English DB - GeoRef N1 - Conference title - Thirty-fifth lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Number of references - 17 N1 - PubXState - TX N1 - Document feature - illus. N1 - SuppNotes - Accessed on June 22, 2007 N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - achondrites; chemical analysis; clay minerals; eucrite; iddingsite; Lafayette Meteorite; meteorites; mineral composition; Serra de Mage Meteorite; sheet silicates; silica; silicates; smectite; stony meteorites; synchrotron X-ray diffraction analysis; synchrotrons; thin sections; X-ray diffraction data; Y 000749; Yamato Meteorites ER - TY - JOUR T1 - Solid-phase As speciation in roaster-derived Au mine tailings AN - 50119094; 2010-003015 JF - Proceedings - International Symposium on Water-Rock Interaction AU - Walker, S R AU - Jamieson, H E AU - Andrade, C F AU - Lanzirotti, A A2 - Wanty, Richard B. A2 - Seal, Robert R., II Y1 - 2004 PY - 2004 DA - 2004 SP - 641 EP - 645 PB - Taylor & Francis VL - 11 SN - 0258-7610, 0258-7610 KW - mining KW - X-ray diffraction data KW - techniques KW - environmental analysis KW - electron probe data KW - XANES spectra KW - Yellowknife Northwest Territories KW - water-rock interaction KW - sediments KW - oxides KW - gold ores KW - spectra KW - geochemistry KW - smelting KW - soils KW - mines KW - waste rock KW - pollutants KW - arsenic KW - pollution KW - X-ray spectra KW - Northwest Territories KW - solid phase KW - Canada KW - dissolved materials KW - metals KW - metal ores KW - Western Canada KW - waste disposal KW - tailings KW - sulfides KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 27A:Economic geology, geology of ore deposits KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50119094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Symposium+on+Water-Rock+Interaction&rft.atitle=Solid-phase+As+speciation+in+roaster-derived+Au+mine+tailings&rft.au=Walker%2C+S+R%3BJamieson%2C+H+E%3BAndrade%2C+C+F%3BLanzirotti%2C+A&rft.aulast=Walker&rft.aufirst=S&rft.date=2004-01-01&rft.volume=11&rft.issue=&rft.spage=641&rft.isbn=9058096416&rft.btitle=&rft.title=Proceedings+-+International+Symposium+on+Water-Rock+Interaction&rft.issn=02587610&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Eleventh international symposium on Water-rock interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 5 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - arsenic; Canada; chemical fractionation; dissolved materials; electron probe data; environmental analysis; geochemistry; gold ores; metal ores; metals; mines; mining; Northwest Territories; oxides; pollutants; pollution; sediments; smelting; soils; solid phase; spectra; sulfides; tailings; techniques; waste disposal; waste rock; water-rock interaction; Western Canada; X-ray diffraction data; X-ray spectra; XANES spectra; Yellowknife Northwest Territories ER - TY - JOUR T1 - Remobilization of precipitated and cell-associated uranium in brines AN - 50118256; 2010-003022 JF - Proceedings - International Symposium on Water-Rock Interaction AU - Dodge, C J AU - Gillow, J B AU - Francis, A J A2 - Wanty, Richard B. A2 - Seal, Robert R., II Y1 - 2004 PY - 2004 DA - 2004 SP - 679 EP - 682 PB - Taylor & Francis VL - 11 SN - 0258-7610, 0258-7610 KW - United States KW - Eddy County New Mexico KW - New Mexico KW - environmental analysis KW - ground water KW - carbon dioxide KW - absorption KW - chemical reactions KW - water-rock interaction KW - transport KW - Waste Isolation Pilot Plant KW - chemical composition KW - geochemistry KW - experimental studies KW - assemblages KW - pollution KW - migration of elements KW - hydrochemistry KW - biogenic processes KW - X-ray data KW - precipitation KW - metals KW - brines KW - bacteria KW - EXAFS data KW - dissolution KW - uranium KW - mobilization KW - transformations KW - actinides KW - microorganisms KW - 02B:Hydrochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50118256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Symposium+on+Water-Rock+Interaction&rft.atitle=Remobilization+of+precipitated+and+cell-associated+uranium+in+brines&rft.au=Dodge%2C+C+J%3BGillow%2C+J+B%3BFrancis%2C+A+J&rft.aulast=Dodge&rft.aufirst=C&rft.date=2004-01-01&rft.volume=11&rft.issue=&rft.spage=679&rft.isbn=9058096416&rft.btitle=&rft.title=Proceedings+-+International+Symposium+on+Water-Rock+Interaction&rft.issn=02587610&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Eleventh international symposium on Water-rock interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 10 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absorption; actinides; assemblages; bacteria; biogenic processes; brines; carbon dioxide; chemical composition; chemical reactions; dissolution; Eddy County New Mexico; environmental analysis; EXAFS data; experimental studies; geochemistry; ground water; hydrochemistry; metals; microorganisms; migration of elements; mobilization; New Mexico; pollution; precipitation; transformations; transport; United States; uranium; Waste Isolation Pilot Plant; water-rock interaction; X-ray data ER - TY - JOUR T1 - Upstream plasticity and downstream robustness in evolution of molecular networks AN - 19815788; 6044832 AB - Gene duplication followed by the functional divergence of the resulting pair of paralogous proteins is a major force shaping molecular networks in living organisms. Recent species-wide data for protein-protein interactions and transcriptional regulations allow us to assess the effect of gene duplication on robustness and plasticity of these molecular networks. We demonstrate that the transcriptional regulation of duplicated genes in baker's yeast Saccharomyces cerevisiae diverges fast so that on average they lose 3% of common transcription factors for every 1% divergence of their amino acid sequences. The set of protein-protein interaction partners of their protein products changes at a slower rate exhibiting a broad plateau for amino acid sequence similarity above 70%. The stability of functional roles of duplicated genes at such relatively low sequence similarity is further corroborated by their ability to substitute for each other in single gene knockout experiments in yeast and RNAi experiments in a nematode worm Caenorhabditis elegans. We also quantified the divergence rate of physical interaction neighborhoods of paralogous proteins in a bacterium Helicobacter pylori and a fly Drosophila melanogaster. However, in the absence of system-wide data on transcription factors' binding in these organisms we could not compare this rate to that of transcriptional regulation of duplicated genes. For all molecular networks studied in this work we found that even the most distantly related paralogous proteins with amino acid sequence identities around 20% on average have more similar positions within a network than a randomly selected pair of proteins. For yeast we also found that the upstream regulation of genes evolves more rapidly than downstream functions of their protein products. This is in accordance with a view which puts regulatory changes as one of the main driving forces of the evolution. In this context a very important open question is to what extent our results obtained for homologous genes within a single species (paralogs) carries over to homologous proteins in different species (orthologs). JF - BMC Evolutionary Biology AU - Maslov, Sergei AU - Sneppen, Kim AU - Eriksen, Kasper Astrup AU - Yan, Koon-Kiu AD - Department of Physics, Brookhaven National Laboratory, Upton, New York 11973, USA, maslov@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 4 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Helicobacter pylori KW - Data processing KW - Transcription KW - Saccharomyces cerevisiae KW - gene duplication KW - Gene regulation KW - Transcription factors KW - Caenorhabditis elegans KW - Drosophila melanogaster KW - RNA-mediated interference KW - Nematoda KW - Evolution KW - Protein interaction KW - Amino acid sequence KW - J 02410:Animal Diseases KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19815788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Evolutionary+Biology&rft.atitle=Upstream+plasticity+and+downstream+robustness+in+evolution+of+molecular+networks&rft.au=Maslov%2C+Sergei%3BSneppen%2C+Kim%3BEriksen%2C+Kasper+Astrup%3BYan%2C+Koon-Kiu&rft.aulast=Maslov&rft.aufirst=Sergei&rft.date=2004-01-01&rft.volume=4&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Evolutionary+Biology&rft.issn=1471-2148&rft_id=info:doi/10.1186%2F1471-2148-4-9 L2 - http://www.biomedcentral.com/content/pdf/1471-2148-4-9.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Transcription factors; Gene regulation; RNA-mediated interference; Transcription; Protein interaction; Evolution; Amino acid sequence; gene duplication; Helicobacter pylori; Drosophila melanogaster; Caenorhabditis elegans; Nematoda; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1186/1471-2148-4-9 ER - TY - JOUR T1 - How Much Is Enough: Real-Time Detection and Identification of Biological Weapon Agents AN - 18035511; 5997621 AB - Winning the war against terrorism will require adoption of new strategies for decision-making, communication, and research and development. This is particularly true with respect to real-time detection and identification (DI) of Biological Weapons (BW). Real-time bio-sensors presently used by the military do not satisfy the requirements for a civilian environment. More sophisticated BW sensors are needed with false positives and false negatives minimized and addressed. Expert first responders and health professionals in a few cities are becoming familiar with Polymerase Chain Reaction (PCR)-based sensors, but are mostly unaware of other real-time BW DI possibilities in the R&D pipeline. The aim of this paper is to provide individuals outside of the BW research community with an overview of the current status and future prospects for real-time BW detection and identification. It is expected that the Dept. of Homeland Security will play an essential role in establishing incentive systems so that the most appropriate research is conducted and evaluated with peer review using both scientists and first responders. This type of overall strategy has the potential to finally produce real-time biosensors with required properties and keep our BW preparedness ahead of our terrorist enemies' emerging capabilities. JF - Journal of Homeland Security and Emergency Management AU - Graham, T W AU - Sabelnikov, A G AD - Brookhaven National Laboratory Y1 - 2004 PY - 2004 DA - 2004 VL - 1 IS - 3 SN - 1547-7355, 1547-7355 KW - Health & Safety Science Abstracts; Risk Abstracts KW - bioterrorism KW - decision making KW - Biosensors KW - Communications KW - Emergency preparedness KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18035511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Homeland+Security+and+Emergency+Management&rft.atitle=How+Much+Is+Enough%3A+Real-Time+Detection+and+Identification+of+Biological+Weapon+Agents&rft.au=Graham%2C+T+W%3BSabelnikov%2C+A+G&rft.aulast=Graham&rft.aufirst=T&rft.date=2004-01-01&rft.volume=1&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Homeland+Security+and+Emergency+Management&rft.issn=15477355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Emergency preparedness; Biosensors; decision making; Communications; bioterrorism ER - TY - JOUR T1 - Chlorophyll Chemistry Before and After Crystals of Photosynthetic Reaction Centers AN - 17823788; 6023485 AB - The experimental, theoretical and structural research leading to the identification and characterization of the (bacterio) chlorophyll species that mediate the primary events of solar energy transduction and dynamics is reviewed and examined from the author's perspective. JF - Photosynthesis Research AU - Fajer, J AD - Materials Science Department, Brookhaven National Laboratory, Building 555, Upton, NY 11973-5000, USA, fajerj@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 165 EP - 172 PB - Kluwer Academic Publishers VL - 80 IS - 1-3 SN - 0166-8595, 0166-8595 KW - Microbiology Abstracts B: Bacteriology KW - Chlorophyll KW - Photosynthesis KW - Reviews KW - Energy transduction KW - Crystals KW - Reaction centers KW - J 02723:Photosynthesis, electron transport and related phenomena UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17823788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photosynthesis+Research&rft.atitle=Chlorophyll+Chemistry+Before+and+After+Crystals+of+Photosynthetic+Reaction+Centers&rft.au=Fajer%2C+J&rft.aulast=Fajer&rft.aufirst=J&rft.date=2004-01-01&rft.volume=80&rft.issue=1-3&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Photosynthesis+Research&rft.issn=01668595&rft_id=info:doi/10.1023%2FB%3APRES.0000030422.69367.db LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chlorophyll; Reaction centers; Reviews; Crystals; Energy transduction; Photosynthesis DO - http://dx.doi.org/10.1023/B:PRES.0000030422.69367.db ER - TY - JOUR T1 - Molecular orientation of ultrahigh molecular weight polyethylene induced by various sliding motions AN - 17588753; 6026156 AB - Wear and wear debris of ultrahigh molecular weight polyethylene (UHMWPE) in joint replacements have been recognized as one of the major contributors to the failure of orthopedic implants. The detailed wear mechanism of polyethylene under biomechanic motions is not well understood. In simulation wear bench tests, it was found that unidirectional sliding produces the least amount of wear, reciprocating motion increases wear significantly, and cross-shear motion (similar to hip and knee joint motion in the human body) produces the highest amount of wear. Conventional wear theories are inadequate to explain this observation. This study utilizes resonant absorption of linearly polarized soft X-rays at a synchrotron radiation beam line to measure the molecular orientation of a UHMWPE surface layer subjected to different wear motions. Carbon-K-edge partial-electron-yield X-ray absorption measurements were done on the worn UHMWPE samples. X-ray absorption measurements show conclusively that the molecular chains of UHMWPE align preferentially parallel to the direction of sliding. Examination under various wear motions showed that unidirectional shear produced the maximum chain orientation, whereas cross-shear wear motions produced the least amount of orientation. When polymeric chains align, the surface layer tends to be more brittle and hard, thus resisting wear. When they do not align, loose chains may be subjected to both Mode I and Mode II fracture, hence increasing the wear rate. This molecular alignment observation may offer an explanation of why different wear motions have different wear characteristics. JF - Journal of Biomedical Materials Research, Part B: Applied Biomaterials AU - Sambasivan, Sharadha AU - Fischer, Daniel A AU - Shen, Ming C AU - Hsu, Stephen M AD - Ceramics Division, MSEL, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, sharadha@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 278 EP - 285 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 70B IS - 2 SN - 0021-9304, 0021-9304 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - ^a Radiation KW - Molecular weight KW - Polyethylene KW - Orthopedics KW - Particulate matter KW - Fractures KW - Biomaterials KW - Knee KW - Biomechanics KW - Joints KW - Hip KW - W 30965:Miscellaneous, Reviews KW - W4 110:Biomedical Materials & Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17588753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.atitle=Molecular+orientation+of+ultrahigh+molecular+weight+polyethylene+induced+by+various+sliding+motions&rft.au=Sambasivan%2C+Sharadha%3BFischer%2C+Daniel+A%3BShen%2C+Ming+C%3BHsu%2C+Stephen+M&rft.aulast=Sambasivan&rft.aufirst=Sharadha&rft.date=2004-01-01&rft.volume=70B&rft.issue=2&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.issn=00219304&rft_id=info:doi/10.1002%2Fjbm.b.30043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Polyethylene; Hip; Molecular weight; ^a Radiation; Joints; Biomechanics; Biomaterials; Particulate matter; Orthopedics; Knee; Fractures DO - http://dx.doi.org/10.1002/jbm.b.30043 ER - TY - JOUR T1 - Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. AN - 71471524; 14673011 AB - The reinforcing effects of drugs of abuse result from the complex interaction between pharmacological effects and conditioned responses. Here we evaluate how expectation affects the response to the stimulant drug methylphenidate in 25 cocaine abusers. The effects of methylphenidate (0.5 mg/kg, i.v.) on brain glucose metabolism (measured by [18F]deoxyglucose-positron emission tomography) and on its reinforcing effects (self-reports of drug effects) were evaluated in four conditions: (1) expecting placebo and receiving placebo; (2) expecting placebo and receiving methylphenidate; (3) expecting methylphenidate and receiving methylphenidate; (4) expecting methylphenidate and receiving placebo. Methylphenidate increased brain glucose metabolism, and the largest changes were in cerebellum, occipital cortex, and thalamus. The increases in metabolism were approximately 50% larger when methylphenidate was expected than when it was not, and these differences were significant in cerebellum (vermis) and thalamus. In contrast, unexpected methylphenidate induced greater increases in left lateral orbitofrontal cortex than when it was expected. Methylphenidate-induced increases in self-reports of "high" were also approximately 50% greater when subjects expected to receive it than when they did not and were significantly correlated with the metabolic increases in thalamus but not in cerebellum. These findings provide evidence that expectation amplifies the effects of methylphenidate in brain and its reinforcing effects. They also suggest that the thalamus, a region involved with conditioned responses, may mediate the enhancement of the reinforcing effects of methylphenidate by expectation and that the orbitofrontal cortex mediates the response to unexpected reinforcement. The enhanced cerebellar activation with expectation may reflect conditioned responses that are not linked to conscious responses. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Ma, Yemin AU - Fowler, Joanna S AU - Zhu, Wei AU - Maynard, Laurence AU - Telang, Frank AU - Vaska, Paul AU - Ding, Yu-Shin AU - Wong, Christopher AU - Swanson, James M AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. nvolkow@nida.nih.gov Y1 - 2003/12/10/ PY - 2003 DA - 2003 Dec 10 SP - 11461 EP - 11468 VL - 23 IS - 36 KW - Central Nervous System Stimulants KW - 0 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Humans KW - Glucose -- metabolism KW - Adult KW - Tomography, Emission-Computed KW - Male KW - Female KW - Central Nervous System Stimulants -- pharmacology KW - Conditioning (Psychology) KW - Methylphenidate -- pharmacology KW - Brain -- drug effects KW - Reinforcement (Psychology) KW - Cocaine-Related Disorders -- psychology KW - Brain -- metabolism KW - Cocaine-Related Disorders -- metabolism KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71471524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Expectation+enhances+the+regional+brain+metabolic+and+the+reinforcing+effects+of+stimulants+in+cocaine+abusers.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BMa%2C+Yemin%3BFowler%2C+Joanna+S%3BZhu%2C+Wei%3BMaynard%2C+Laurence%3BTelang%2C+Frank%3BVaska%2C+Paul%3BDing%2C+Yu-Shin%3BWong%2C+Christopher%3BSwanson%2C+James+M&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2003-12-10&rft.volume=23&rft.issue=36&rft.spage=11461&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-16 N1 - Date created - 2003-12-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine. AN - 71413718; 12888780 AB - Positron emission tomography (PET), in combination with (11)C-raclopride, was used to examine the effects of phencyclidine (PCP) on dopamine (DA) in the primate striatum. In addition, we explored the hypotheses that GABAergic pathways as well as molecular targets beyond the N-methyl-D-aspartate (NMDA) receptor complex (ie dopamine transporter proteins, DAT) contribute to PCP's effects. In the first series of experiments, (11)C-raclopride was administered at baseline and 30 min following intravenous PCP administration. In the second series of studies, gamma-vinyl GABA (GVG) was used to assess whether enhanced GABAergic tone altered NMDA antagonist-induced changes in DA. Animals received an initial PET scan followed by pretreatment with GVG (300 mg/kg), then PCP 30 min prior to a second scan. Finally, we explored the possible contributions of DAT blockade to PCP-induced increases in DA. By examining (11)C-cocaine binding a paradigm in which PCP was coadministered with the radiotracer, we assessed the direct competition between these two compounds for the DAT. At 0.1, 0.5, and 1.0 mg/kg, PCP decreased (11)C-raclopride binding by 2.1, 14.9+/-2.2 and 8.18+/-1.1%, respectively. These effects were completely attenuated by GVG (3.38+/-3.1% decrease in (11)C-raclopride binding). Finally, PCP (0.5 mg/kg) decreased (11)C-cocaine binding by 25.5+/-4.3%, while at 1.0 mg/kg this decrease was 13.5%, consistent with a competitive interaction at the DAT. These results suggest that PCP may be exerting some direct effects through the DAT and that GABA partially modulates NMDA-antagonist-induced increases in striatal DA. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Schiffer, Wynne K AU - Logan, Jean AU - Dewey, Stephen L AD - SUNY Stony Brook, Department of Neurobiology and Behavior, Stony Brook, NY 11973, USA. wynne@bnl.gov Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 2192 EP - 2198 VL - 28 IS - 12 SN - 0893-133X, 0893-133X KW - Anticonvulsants KW - 0 KW - Antipsychotic Agents KW - Carbon Isotopes KW - Excitatory Amino Acid Antagonists KW - Raclopride KW - 430K3SOZ7G KW - Vigabatrin KW - GR120KRT6K KW - Cocaine KW - I5Y540LHVR KW - Phencyclidine KW - J1DOI7UV76 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Papio KW - Animals KW - Cerebellum -- diagnostic imaging KW - Vigabatrin -- pharmacology KW - Analysis of Variance KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Cerebellum -- metabolism KW - Anticonvulsants -- pharmacology KW - Antipsychotic Agents -- pharmacokinetics KW - Cerebellum -- drug effects KW - Carbon Isotopes -- pharmacokinetics KW - Cocaine -- pharmacokinetics KW - Time Factors KW - Raclopride -- pharmacokinetics KW - Female KW - Corpus Striatum -- diagnostic imaging KW - Corpus Striatum -- metabolism KW - Phencyclidine -- pharmacology KW - Tomography, Emission-Computed KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Excitatory Amino Acid Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71413718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Positron+emission+tomography+studies+of+potential+mechanisms+underlying+phencyclidine-induced+alterations+in+striatal+dopamine.&rft.au=Schiffer%2C+Wynne+K%3BLogan%2C+Jean%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2003-12-01&rft.volume=28&rft.issue=12&rft.spage=2192&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-10 N1 - Date created - 2003-11-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Dr. Mow Lin (1941-2003) AN - 51532152; 2006-086340 JF - Bulletin - Geothermal Resources Council AU - Seubert, Liz AU - Berndt, Marita Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 245 PB - Geothermal Resources Council, Davis, CA VL - 32 IS - 6 SN - 0160-7782, 0160-7782 KW - energy sources KW - Lin, Mow KW - biography KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51532152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+-+Geothermal+Resources+Council&rft.atitle=Dr.+Mow+Lin+%281941-2003%29&rft.au=Seubert%2C+Liz%3BBerndt%2C+Marita&rft.aulast=Seubert&rft.aufirst=Liz&rft.date=2003-12-01&rft.volume=32&rft.issue=6&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Bulletin+-+Geothermal+Resources+Council&rft.issn=01607782&rft_id=info:doi/ L2 - http://geothermal.org/bulletin.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - PubXState - CA N1 - Document feature - illus. N1 - Last updated - 2013-06-13 N1 - CODEN - BGRCDD N1 - SubjectsTermNotLitGenreText - biography; energy sources; Lin, Mow ER - TY - JOUR T1 - In situ high pressure angle dispersive X-ray diffraction experiments; with sagittally-bent double Laue monochomator AN - 51380764; 2007-105517 JF - Eos, Transactions, American Geophysical Union AU - Hu, Jingzhu AU - Zhong, Zhong AU - Liu, Hauzhe AU - Guo, Quanzhong AU - Mao, Ho-kwang AU - Hemley, Russell J AU - Anonymous Y1 - 2003/12// PY - 2003 DA - December 2003 SP - F1590 EP - F1591 PB - American Geophysical Union, Washington, DC VL - 84 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - physical properties KW - experimental studies KW - pressure KW - in situ KW - X-ray diffraction data KW - techniques KW - anvil cells KW - high pressure KW - minerals KW - instruments KW - measurement KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51380764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=In+situ+high+pressure+angle+dispersive+X-ray+diffraction+experiments%3B+with+sagittally-bent+double+Laue+monochomator&rft.au=Hu%2C+Jingzhu%3BZhong%2C+Zhong%3BLiu%2C+Hauzhe%3BGuo%2C+Quanzhong%3BMao%2C+Ho-kwang%3BHemley%2C+Russell+J%3BAnonymous&rft.aulast=Hu&rft.aufirst=Jingzhu&rft.date=2003-12-01&rft.volume=84&rft.issue=46%2C+Suppl.&rft.spage=F1590&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2003 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - anvil cells; experimental studies; high pressure; in situ; instruments; measurement; minerals; physical properties; pressure; techniques; X-ray diffraction data ER - TY - JOUR T1 - Biotransformation of Pu(VI) by microorganisms AN - 51010454; 2008-093545 JF - Eos, Transactions, American Geophysical Union AU - Ohnuki, Toshihiko AU - Yoshida, Takahiro AU - Ozaki, Takuo AU - Francis, Arokiasamy J AU - Anonymous Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 1 PB - American Geophysical Union, Washington, DC VL - 84 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - silicates KW - high-level waste KW - sorption KW - experimental studies KW - Bacillus subtilis KW - plutonium KW - oxidation KW - kaolinite KW - bioremediation KW - remediation KW - radioactive waste KW - clay minerals KW - biogenic processes KW - transport KW - metals KW - bacteria KW - sheet silicates KW - waste disposal KW - transformations KW - Bacillus KW - actinides KW - pH KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51010454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Biotransformation+of+Pu%28VI%29+by+microorganisms&rft.au=Ohnuki%2C+Toshihiko%3BYoshida%2C+Takahiro%3BOzaki%2C+Takuo%3BFrancis%2C+Arokiasamy+J%3BAnonymous&rft.aulast=Ohnuki&rft.aufirst=Toshihiko&rft.date=2003-12-01&rft.volume=84&rft.issue=46%2C+Suppl.&rft.spage=F308&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2003 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - actinides; Bacillus; Bacillus subtilis; bacteria; biogenic processes; bioremediation; clay minerals; experimental studies; high-level waste; kaolinite; metals; microorganisms; oxidation; pH; plutonium; radioactive waste; remediation; sheet silicates; silicates; sorption; transformations; transport; waste disposal ER - TY - JOUR T1 - Organic sulfur associated with aquatic humic substances AN - 50419749; 2009-054913 JF - Eos, Transactions, American Geophysical Union AU - Aiken, George AU - Vairavamurthy, Murthy A AU - Ravichandran, Mahalingham AU - Anonymous Y1 - 2003/12// PY - 2003 DA - December 2003 SP - Abstract B52F EP - 06 PB - American Geophysical Union, Washington, DC VL - 84 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - thiophenes KW - Everglades KW - oxidation KW - Florida KW - X-ray spectra KW - XANES spectra KW - reactivity KW - organic compounds KW - humic substances KW - quantitative analysis KW - dissolved materials KW - metals KW - Pacific Ocean KW - thiols KW - sulfur KW - spectra KW - aquatic environment KW - organic sulfur KW - Eh KW - mercury KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50419749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Organic+sulfur+associated+with+aquatic+humic+substances&rft.au=Aiken%2C+George%3BVairavamurthy%2C+Murthy+A%3BRavichandran%2C+Mahalingham%3BAnonymous&rft.aulast=Aiken&rft.aufirst=George&rft.date=2003-12-01&rft.volume=84&rft.issue=46%2C+Suppl.&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2003 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - aquatic environment; chemical fractionation; dissolved materials; Eh; Everglades; Florida; humic substances; mercury; metals; organic compounds; organic sulfur; oxidation; Pacific Ocean; quantitative analysis; reactivity; spectra; sulfur; thiols; thiophenes; United States; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Airborne measurement of inorganic ionic components of fine aerosol particles using the particle-into-liquid sampler coupled to ion chromatography technique during ACE-Asia and TRACE-P AN - 1654672792; 21161019 AB - Eight inorganic ions in fine aerosol particles (D sub(p) 1 ppbv only in the top 1% sample population. During TRACE-P, NH sub(4) super(+) dominated, followed by SO sub(4) super(2-), Cl super(-), Na super(+), NO sub(3) super(-), Ca super(2+), and K super(+), in decreasing order of importance. In addition to a sea-salt origin, Cl super(-) showed a source in urban emissions possibly related to biofuel combustion. Both sea salt and dust contributed to Mg super(2+). In both experiments, NH sub(4) super(+), SO sub(4) super(2-), NO sub(3) super(-), and CO were strongly correlated, indicating that combustion was the dominant source of these species and that NH sub(3) and other alkaline materials were in sufficient supply to neutralize H sub(2)SO sub(4). The [NH sub(4) super(+)] to ([NO sub(3) super(-)] + 2[SO sub(4) super(2-)]) ratio was 0.70 in the two campaigns, with deviations found only in volcano plumes, whereby SO sub(4) super(2-) was found to correlate with SO sub(2). Charge balance of the ions showed both positive and negative deviations whose magnitudes, 30%, provide estimates of the lower limits of unmeasured ions. Elevated NO sub(3) super(-) and Ca super(2+) coexist mainly under polluted conditions, suggesting the importance of sequestering HNO sub(3) by mineral dust. JF - Journal of Geophysical Research: Atmospheres AU - Lee, Y-N AU - Weber, R AU - Ma, Y AU - Orsini, D AU - Maxwell-Meier, K AU - Blake, D AU - Meinardi, S AU - Sachse, G AU - Harward, C AU - Chen, T-Y AU - Thornton, D AU - Tu, F-H AU - Bandy, A AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York, USA. Y1 - 2003/12// PY - 2003 DA - Dec 2003 SP - [np] VL - 108 IS - D23 SN - 0148-0227, 0148-0227 KW - Pollution Abstracts KW - Fuel technology KW - Ions KW - Aerosols KW - Chromatography KW - Volcanoes KW - Particulates KW - Dust KW - Combustion KW - Salts KW - Sulfur dioxide KW - Aircraft KW - Emissions KW - Plumes KW - Biofuels KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654672792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research%3A+Atmospheres&rft.atitle=Airborne+measurement+of+inorganic+ionic+components+of+fine+aerosol+particles+using+the+particle-into-liquid+sampler+coupled+to+ion+chromatography+technique+during+ACE-Asia+and+TRACE-P&rft.au=Lee%2C+Y-N%3BWeber%2C+R%3BMa%2C+Y%3BOrsini%2C+D%3BMaxwell-Meier%2C+K%3BBlake%2C+D%3BMeinardi%2C+S%3BSachse%2C+G%3BHarward%2C+C%3BChen%2C+T-Y%3BThornton%2C+D%3BTu%2C+F-H%3BBandy%2C+A&rft.aulast=Lee&rft.aufirst=Y-N&rft.date=2003-12-01&rft.volume=108&rft.issue=D23&rft.spage=%5Bnp%5D&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research%3A+Atmospheres&rft.issn=01480227&rft_id=info:doi/10.1029%2F2002JD003265 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-02-12 N1 - SubjectsTermNotLitGenreText - Ions; Fuel technology; Aerosols; Chromatography; Volcanoes; Particulates; Dust; Combustion; Salts; Sulfur dioxide; Aircraft; Emissions; Plumes; Biofuels DO - http://dx.doi.org/10.1029/2002JD003265 ER - TY - JOUR T1 - A comparative study of O sub(3) formation in the Houston urban and industrial plumes during the 2000 Texas Air Quality Study AN - 16163880; 5821841 AB - Ozone formation in the Houston area during a period of high ozone concentrations that occurred on 29 August 2000 during the TexAQS 2000 study is examined to understand differences in the sources of O sub(3) precursors and the rate and efficiency of ozone formation over the city of Houston and the industrialized Ship Channel region to the east of Houston. From late morning through late afternoon on 29 August, a period of stagnation occurred, allowing accumulation of O sub(3) and product species separately over downtown Houston and the Houston Ship Channel. Three aircraft flights were made in the region, starting from about 0900 CST and extending to about 1700 CST. A localized plume of high O sub(3) ranging between 120 and 200 ppb was observed over the Ship Channel on all of these aircraft flights. Over the same time period, O sub(3) concentrations over the city were much lower ranging between 40 and 90 ppb. NO sub(x) concentrations measured in the two regions in the late morning were roughly the same, but hydrocarbon reactivities over the industrial area were much higher, by as much as a factor of 10. Photochemical box model calculations constrained by observations of NO sub(x), hydrocarbons, O sub(3), and other stable species indicated that the instantaneous ozone formation rate was much lower (3- 18 ppb/h) over downtown Houston than it was over the Ship Channel (3-80 ppb/h). The much faster O sub(3) formation rates and higher concentrations observed over the Ship Channel are attributed to the much higher hydrocarbon reactivity, the majority of which was contributed by low molecular weight alkenes. These high hydrocarbon reactivities also caused O sub(3) over the Ship Channel to be produced with much higher efficiency than over urban Houston. Comparison of photochemical product distributions suggests that O sub(3) formation in the urban area is much more hydrocarbon limited than in the Ship Channel, consistent with the geographic distribution of major hydrocarbon sources in the area. JF - Journal of Geophysical Research. D. Atmospheres AU - Daum, PH AU - Kleinman, LI AU - Springston AU - Nunnermacker, L J AU - Lee, Y-N AU - Weinstein-Lloyd, J AU - Zheng, J AU - Berkowitz, C M AD - Environmental Sciences Department, Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York, USA Y1 - 2003/12// PY - 2003 DA - Dec 2003 PB - American Geophysical Union, 2000 Florida Ave., N.W. Washington DC 20009 USA, [mailto:service@agu.org], [URL:http://www.agu.org] VL - 108 IS - D23 SN - 0148-0227, 0148-0227 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Citation No. 4715 KW - urban pollution KW - ozone formation KW - industrial hydrocarbons KW - 0345 Atmospheric Composition and Structure: Pollution KW - urban and regional (0305) KW - 0365 Atmospheric Composition and Structure: Troposphere KW - composition and chemistry KW - 0368 Atmospheric Composition and Structure: Troposphere KW - constituent transport and chemistry KW - Ships KW - Air quality measurements KW - Photochemical ozone production KW - Hydrocarbons KW - Nitrogen oxides KW - Atmosphere KW - Ozone formation KW - Air quality models KW - Airplane observation of ozone KW - Industrial areas KW - Plumes KW - USA, Texas, Houston KW - Marine transportation KW - Industrial atmospheric pollution KW - Ozone KW - Urban areas KW - Plume dispersion KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - M2 551.556.42:Short-range: plumes (551.556.42) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16163880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.atitle=A+comparative+study+of+O+sub%283%29+formation+in+the+Houston+urban+and+industrial+plumes+during+the+2000+Texas+Air+Quality+Study&rft.au=Daum%2C+PH%3BKleinman%2C+LI%3BSpringston%3BNunnermacker%2C+L+J%3BLee%2C+Y-N%3BWeinstein-Lloyd%2C+J%3BZheng%2C+J%3BBerkowitz%2C+C+M&rft.aulast=Daum&rft.aufirst=PH&rft.date=2003-12-01&rft.volume=108&rft.issue=D23&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.issn=01480227&rft_id=info:doi/10.1029%2F2003JD003552 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2004-06-01 N1 - SuppNotes - Publication date refers to online version. N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Photochemical ozone production; Airplane observation of ozone; Industrial atmospheric pollution; Ozone formation; Air quality models; Plume dispersion; Ships; Air quality measurements; Hydrocarbons; Industrial areas; Nitrogen oxides; Atmosphere; Plumes; Marine transportation; Urban areas; Ozone; USA, Texas, Houston DO - http://dx.doi.org/10.1029/2003JD003552 ER - TY - JOUR T1 - The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site. AN - 71361309; 14609324 AB - Methemoglobinemia, the first hereditary disease to be identified that involved an enzyme deficiency, has been ascribed to mutations in the enzyme cytochrome b(5) reductase. A variety of defects in either the erythrocytic or microsomal forms of the enzyme have been identified that give rise to the type I or type II variant of the disease, respectively. The positions of the methemoglobinemia-causing mutations are scattered throughout the protein sequence, but the majority of the nontruncated mutants that produce type II symptoms occur close to the flavin adenine dinucleotide (FAD) cofactor binding site. While X-ray structures have been determined for the soluble, flavin-containing diaphorase domains of the rat and pig enzymes, no X-ray or NMR structure has been described for the human enzyme or any of the methemoglobinemia variants. S127P, a mutant that causes type II methemoglobinemia, was the first to be positively identified and have its spectroscopic and kinetic properties characterized that revealed altered nicotinamide adenine dinucleotide hydride (NADH) substrate binding behavior. To understand these changes at a structural level, we have determined the structure of the S127P mutant of rat cytochrome b(5) reductase to 1.8 A resolution, providing the first structural snapshot of a cytochrome b(5) reductase mutant that causes methemoglobinemia. The high-resolution structure revealed that the adenosine diphosphate (ADP) moiety of the FAD prosthetic group is displaced into the corresponding ADP binding site of the physiological substrate, NADH, thus acting as a substrate inhibitor which is consistent with both the spectroscopic and kinetic data. JF - Biochemistry AU - Bewley, Maria C AU - Davis, C Ainsley AU - Marohnic, Christopher C AU - Taormina, David AU - Barber, Michael J AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. mcb21@psu.edu Y1 - 2003/11/18/ PY - 2003 DA - 2003 Nov 18 SP - 13145 EP - 13151 VL - 42 IS - 45 SN - 0006-2960, 0006-2960 KW - Recombinant Proteins KW - 0 KW - NAD KW - 0U46U6E8UK KW - Flavin-Adenine Dinucleotide KW - 146-14-5 KW - Adenosine Monophosphate KW - 415SHH325A KW - Serine KW - 452VLY9402 KW - Proline KW - 9DLQ4CIU6V KW - Cytochrome-B(5) Reductase KW - EC 1.6.2.2 KW - Index Medicus KW - Animals KW - Recombinant Proteins -- chemical synthesis KW - Humans KW - Spectrophotometry, Ultraviolet KW - Substrate Specificity -- genetics KW - Recombinant Proteins -- genetics KW - Serine -- genetics KW - Proline -- genetics KW - Rats KW - NAD -- metabolism KW - Kinetics KW - Crystallography, X-Ray KW - Binding Sites -- genetics KW - Protein Conformation KW - Mutagenesis, Site-Directed KW - Cytochrome-B(5) Reductase -- metabolism KW - Cytochrome-B(5) Reductase -- genetics KW - Cytochrome-B(5) Reductase -- chemistry KW - Amino Acid Substitution -- genetics KW - Adenosine Monophosphate -- metabolism KW - Methemoglobinemia -- genetics KW - Flavin-Adenine Dinucleotide -- chemistry KW - Adenosine Monophosphate -- chemistry KW - Methemoglobinemia -- enzymology KW - Flavin-Adenine Dinucleotide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71361309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=The+structure+of+the+S127P+mutant+of+cytochrome+b5+reductase+that+causes+methemoglobinemia+shows+the+AMP+moiety+of+the+flavin+occupying+the+substrate+binding+site.&rft.au=Bewley%2C+Maria+C%3BDavis%2C+C+Ainsley%3BMarohnic%2C+Christopher+C%3BTaormina%2C+David%3BBarber%2C+Michael+J&rft.aulast=Bewley&rft.aufirst=Maria&rft.date=2003-11-18&rft.volume=42&rft.issue=45&rft.spage=13145&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-04 N1 - Date created - 2003-11-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Uptake and release of cesium-137 by five plant species as influenced by soil amendments in field experiments. AN - 71468923; 14674551 AB - Phytoextraction field experiments were conducted on soil contaminated with 0.39 to 8.7 Bq/g of 137Cs to determine the capacity of five plant species to accumulate 137Cs and the effects of three soil treatments on uptake. The plants tested were redroot pigweed (Amaranthus retroflexus L. var. aureus); a mixture of redroot pigweed and spreading pigweed (A. graecizans L.); purple amaranth (A. cruteus L.) x Powell's amaranth (A. powellii S. Watson), referred to here as the amaranth hybrid; Indian mustard [Brassica juncea (L.) Czern.]; and cabbage (Brassica oleracea L. var. capitata). For control plants, the concentration ratios (CR) of 137Cs were greatest for redroot pigweed and the amaranth hybrid, with average CR values of 1.0 +/- 0.24 and 0.95 +/- 0.14, respectively. The lowest value was for Indian mustard at 0.36 +/- 0.10. The soil treatments included (i) application of NH4NO3 solution to the soil after plants had matured, (ii) addition of composted manure to increase organic matter content of the soil, (iii) combination of the manure and ammonium solution treatments, and (iv) controls. The ammonium solution gave little overall increase in accumulation of 137Cs. The use of composted manure also had little influence, but the combination of the composted manure with application of ammonium solutions had a distinctly negative effect on plant uptake of 137Cs. On average the fraction of 137Cs taken up from the soil was reduced by 57.4 +/- 1.2% compared with controls. This was the result of release of competing ions, primarily Ca, from the manure and was observed across all five plant species tested. The application of ammonium solution took place in the last two weeks before harvest. The reduction of plant 137Cs content, by addition of the ammonium solution, as it interacted with the manure, indicates that substantial quantities 137Cs can be released from the shoots of plants as a result of sudden changes in soil solution chemistry. JF - Journal of environmental quality AU - Fuhrmann, Mark AU - Lasat, Mitch AU - Ebbs, Stephen AU - Cornish, Jay AU - Kochian, Leon AD - Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973-5000, USA. fuhrmann@bnl.gov PY - 2003 SP - 2272 EP - 2279 VL - 32 IS - 6 SN - 0047-2425, 0047-2425 KW - Cesium Radioisotopes KW - 0 KW - Manure KW - Nitrates KW - Soil Pollutants, Radioactive KW - ammonium nitrate KW - T8YA51M7Y6 KW - Index Medicus KW - Humans KW - Nitrates -- pharmacology KW - Conservation of Natural Resources KW - Cesium Radioisotopes -- pharmacokinetics KW - Amaranthus -- metabolism KW - Brassica -- metabolism KW - Soil Pollutants, Radioactive -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71468923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+quality&rft.atitle=Uptake+and+release+of+cesium-137+by+five+plant+species+as+influenced+by+soil+amendments+in+field+experiments.&rft.au=Fuhrmann%2C+Mark%3BLasat%2C+Mitch%3BEbbs%2C+Stephen%3BCornish%2C+Jay%3BKochian%2C+Leon&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2003-11-01&rft.volume=32&rft.issue=6&rft.spage=2272&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-29 N1 - Date created - 2003-12-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - In situ high-pressure synchrotron X-ray powder diffraction study of tunnel manganese oxide minerals AN - 51812714; 2004-065455 AB - Microporous Mn oxides are valued for their catalytic, ion exchange, electrochemical, and adsorption properties. Of particular interest have been Mn-oxide catalysts with large tunnel structures; they exhibit a range of tunnel shapes and sizes that offer potential for complementary catalytic or cation-exchange applications. We used synchrotron powder X-ray diffraction to study structural changes with increasing pressure for three tunnel Mn oxide minerals. Experiments were performed using a Diamond Anvil Cell (DAC) at beamline X7A at the National Synchrotron Light Source, Brookhaven National Laboratory. Powdered samples of hollandite [(Ba (sub .75) ,Pb (sub .16) Na (sub .10) K (sub .04) )(Mn,Fe) (sub 8) O (sub 16) ], romanechite (Ba (sub .66) Mn (sub 5) O (sub 10) . 1.34H (sub 2) O), and todorokite [(Mg (sub .45) ,Na (sub .42) ,Ca (sub .15) )Mn (sub 6) O (sub 12) . 4H (sub 2) O] were, in turn, loaded into the DAC at ambient pressure and room temperature along with a few small ruby chips. A mixture of methanol:ethanol:water was used as a pressure transmitting fluid. The pressure at the sample was measured using the shift in the R1 emission line of the included ruby chips. Data were collected with a gas-proportional position-sensitive detector and radiation wavelength of 0.6839(1) Aa. Powder X-ray diffraction data were measured at pressure increments of 0.5-1.0 GPa between ambient pressure and 7 GPa; the samples were equilibrated for about 15 minutes or more at each measured pressure. A second set of measurements was made for each sample as the pressure was released. Unit-cell parameters were determined by whole pattern fitting using the LeBail method. The hollandite structure (I2/m) has tunnels with square cross-sections measuring 2 octahedra on an edge (2 X 2), and as pressure increased to approximately 3 GPa, the a-axis lengthened, b and c and unit-cell volume decreased, and beta increased. Above approximately 3 GPa, a started to decrease, and the slopes of the changes for the other parameters changed, suggesting a phase transition at about 3 GPa. Romanechite (C2/m) has 2 X 3 tunnels, and with increasing pressure all axial parameters and volume decreased and beta increased, exhibiting a slight change in slope at approximately 2 GPa. For the todorokite structure (P2/m), with 3 X 3 tunnels, the c-axis increased slightly below 1 GPa, but at higher pressures all of the axial parameters and unit-cell volume decreased and beta increased, consistent with a steady collapse of the tunnels. JF - Abstracts with Programs - Geological Society of America AU - Lee, Yongjae AU - Post, Jeffrey E AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 536 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - experimental studies KW - pressure KW - in situ KW - X-ray diffraction data KW - tunnel structures KW - phase transitions KW - crystal structure KW - powder method KW - high pressure KW - todorokite KW - laboratory studies KW - romanechite KW - manganese oxides KW - oxides KW - synchrotrons KW - anvil cells KW - 17A:General geophysics KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51812714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=In+situ+high-pressure+synchrotron+X-ray+powder+diffraction+study+of+tunnel+manganese+oxide+minerals&rft.au=Lee%2C+Yongjae%3BPost%2C+Jeffrey+E%3BAnonymous&rft.aulast=Lee&rft.aufirst=Yongjae&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - anvil cells; crystal structure; experimental studies; high pressure; in situ; laboratory studies; manganese oxides; oxides; phase transitions; powder method; pressure; romanechite; synchrotrons; todorokite; tunnel structures; X-ray diffraction data ER - TY - JOUR T1 - Applications of crystal chemistry to mineral surface geochemistry AN - 51812274; 2004-065459 AB - Mineral surface geochemistry deals with the interaction of biological organisms and chemical species, including water, with mineral surfaces. The interaction of mineral surfaces with heavy metals and metalloids in aqueous solutions is of major interest because of the possibility they can sorb on mineral surfaces, which can effectively sequester them in specific pH ranges. XAFS spectroscopy studies have yielded quantitative information about the structures and modes of binding of cations and oxoanions at mineral/water interfaces. However, what is not known in most cases is the structure of the mineral surface in contact with water and how protons contribute to the stability of metal sorption complexes. Crystal chemical principles, including Pauling's bond valence principle, can be used to help constrain the types of surface sites to which metal(loid)s can bind, as well as the number of protons that can bind to a surface oxygen that is also bonded to a metal(loid) ion. In an extension of this approach, we have carried out grazing-incidence EXAFS studies of Pb(II) sorption on single crystal hematite surfaces in contact with water. Pb(II) was found to bind dominantly in an inner-sphere, bidentate fashion to FeO6 octahedra on the a-Fe2O3 (0001) and (1-102) surfaces, which is consistent with our earlier study of Pb(II) binding to a-Al2O3 (1-102) (J. Colloid Interface Sci. 1997, 85, 473). In contrast, we found that Pb(II) forms dominantly outer sphere complexes at the a-Al2O3 (0001)/water interface (Geochim. Cosmochim. Acta 1996, 60, 3541). In order to understand these differences in reactivity, we have recently carried out crystal truncation rod diffraction studies of these hydrated surfaces. This CTR work found significant structural differences between the (0001) surfaces of a-Fe2O3 and a-Al2O3, which helps explain their differences in reactivity to Pb(II). Application of crystal chemical principles to these metal/metal oxide systems, as well as to those in which AsO43- and SeO42- are aqueous sorbents, helps constrain their sorption behavior as well as proton release. JF - Abstracts with Programs - Geological Society of America AU - Brown, Gordon E AU - Bargar, John R AU - Trainor, Thomas P AU - Eng, Peter J AU - Fitts, Jeffrey P AU - Waychunas, Glenn A AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 536 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - experimental studies KW - colloidal materials KW - mineral-water interface KW - lead KW - crystal structure KW - bonding KW - hydration KW - chemical reactions KW - hematite KW - metals KW - EXAFS data KW - oxides KW - valency KW - crystal chemistry KW - mineral surface KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51812274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Applications+of+crystal+chemistry+to+mineral+surface+geochemistry&rft.au=Brown%2C+Gordon+E%3BBargar%2C+John+R%3BTrainor%2C+Thomas+P%3BEng%2C+Peter+J%3BFitts%2C+Jeffrey+P%3BWaychunas%2C+Glenn+A%3BAnonymous&rft.aulast=Brown&rft.aufirst=Gordon&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - bonding; chemical reactions; colloidal materials; crystal chemistry; crystal structure; EXAFS data; experimental studies; hematite; hydration; lead; metals; mineral surface; mineral-water interface; oxides; valency ER - TY - JOUR T1 - Inelastic X-ray scattering and X-ray diffraction study of graphite at high pressure AN - 51796191; 2004-073781 AB - Near K-edge features measured by x-ray absorption or electron energy loss spectroscopy provide rich information about the chemical bonding and have been used as quantitative tools to investigate a variety of carbon bonding in organic and inorganic materials. However, the low-energy x-ray and electron probes require vacuum environment, and are completely inaccessible, blocked by the pressure vessels for high-pressure studies, as the soft x-ray and electron beams. Synchrotron inelastic x-ray scattering (IXS) (also called x-ray Raman) spectroscopy, is capable of penetrating high pressure vessels and probing the bonding of samples at high-pressure in-situ. Although this technique was demonstrated almost forty years ago, it has only recently been successfully applied to ambient pressure studies. Compressed under ambient temperature, graphite undergoes a transition at approximately 17 GPa. The near K-edge spectroscopy of carbon using synchrotron x-ray inelastic scattering reveals that half of the pi-bonds between graphite layers convert to sigma-bonds while the other half remain as pi-bonds in the high-pressure form. The x-ray diffraction pattern of the high-pressure form, using He as a pressure transmitting medium, is consistent with a distorted graphite structure in which bridging carbon atoms between graphite layers pair and form sigma-bonds, while the non-bridging carbon atoms remain unpaired with dangling pi-bonds. The high-pressure form is superhard, capable of indenting cubic diamond single crystals. JF - Abstracts with Programs - Geological Society of America AU - Mao, Wendy L AU - Mao, Ho-kwang AU - Eng, Peter J AU - Trainor, Thomas P AU - Newville, Matthew AU - Kao, Chi-chang AU - Heinz, Dion L AU - Shu, Jinfu AU - Hemley, Russell J AU - Meng, Yue AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 622 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - experimental studies KW - pressure KW - X-ray diffraction data KW - crystal structure KW - native elements KW - high pressure KW - X-ray spectra KW - temperature KW - synchrotron radiation KW - laboratory studies KW - graphite KW - Raman spectra KW - spectra KW - compression KW - 17A:General geophysics KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51796191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Inelastic+X-ray+scattering+and+X-ray+diffraction+study+of+graphite+at+high+pressure&rft.au=Mao%2C+Wendy+L%3BMao%2C+Ho-kwang%3BEng%2C+Peter+J%3BTrainor%2C+Thomas+P%3BNewville%2C+Matthew%3BKao%2C+Chi-chang%3BHeinz%2C+Dion+L%3BShu%2C+Jinfu%3BHemley%2C+Russell+J%3BMeng%2C+Yue%3BAnonymous&rft.aulast=Mao&rft.aufirst=Wendy&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - compression; crystal structure; experimental studies; graphite; high pressure; laboratory studies; native elements; pressure; Raman spectra; spectra; synchrotron radiation; temperature; X-ray diffraction data; X-ray spectra ER - TY - JOUR T1 - Hydrogen exchange in Na-birnessite; a time-resolved synchrotron X-ray diffraction analysis AN - 51794639; 2004-073772 AB - Manganese oxide minerals having the birnessite-type layer structure occur in a wide variety of geological settings, including soils, Mn nodules, and rock varnishes. Mn oxides readily participate in cation-exchange and oxidation-reduction reactions, and because they typically form as coatings and fine-grained aggregates with large surface areas, even small quantities can significantly affect the chemical composition and behavior of sediments and associated aqueous systems. Additionally, because of their great chemical activity, synthetic birnessite-like phases are being extensively studied as possible catalysts, cation-exchange agents and battery materials. Of critical importance to the possible usage of birnessite as a cathodic material in solid-state batteries is its capacity to incorporate H ions during battery discharge. In this study, we examined the exchange of H for Na in birnessite in real time through synchrotron X-ray diffraction. Na-birnessite powders were exposed to HCl solutions (pH 3) at room temperature in a quartz capillary flow-through cell for approximately 1 hr, by which time H exchange was complete. Data were collected with an imaging plate, which allowed full-pattern diffraction patterns to be obtained every 2 minutes. Rietveld analyses of these time-resolved diffraction experiments confirm the proposition that endmember hexagonal H-birnessite appears and grows concomitant with the replacement of Na by H in the triclinic starting material (Drits et al. 1997). Hexagonal H-birnessite first was observed after 20 minutes of solution flow and increased in abundance (as revealed by refined weight fractions) linearly with time at the expense of the triclinic birnessite, which was not discernible after 60 minutes. Substitution of H into triclinic Na-birnessite was manifested by systematic decreases in the a, b, c, and beta lattice values beginning 10 minutes after fluid flow was initiated, contributing to a volume decrease of approximately 1%. Refined occupancies of the octahedral Mn in the hexagonal H-birnessite suggest that some Mn cations occupy the interlayer. JF - Abstracts with Programs - Geological Society of America AU - Heaney, Peter J AU - Post, Jeffrey E AU - Lopano, Christina L AU - Hanson, Jonathan C AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 620 EP - 621 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - experimental studies KW - X-ray diffraction data KW - Rietveld refinement KW - synchrotron radiation KW - birnessite KW - hydrogen KW - oxides KW - applications KW - Na-birnessite KW - ion exchange KW - crystal chemistry KW - industrial minerals KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51794639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Hydrogen+exchange+in+Na-birnessite%3B+a+time-resolved+synchrotron+X-ray+diffraction+analysis&rft.au=Heaney%2C+Peter+J%3BPost%2C+Jeffrey+E%3BLopano%2C+Christina+L%3BHanson%2C+Jonathan+C%3BAnonymous&rft.aulast=Heaney&rft.aufirst=Peter&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - applications; birnessite; crystal chemistry; experimental studies; hydrogen; industrial minerals; ion exchange; Na-birnessite; oxides; Rietveld refinement; synchrotron radiation; X-ray diffraction data ER - TY - JOUR T1 - Scotian Shelf crossovers during winter/spring 1999 AN - 51771843; 2005-002103 JF - Journal of Geophysical Research AU - Smith, Peter C AU - Flagg, Charles N AU - Limeburner, Richard AU - Fuentes-Yaco, Cesar AU - Hannah, Charles AU - Beardsley, Robert C AU - Irish, James D AU - Lee, Craig M Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 31 PB - American Geophysical Union, Washington, DC VL - 108 IS - C11 SN - 0148-0227, 0148-0227 KW - currents KW - Browns Bank KW - ocean circulation KW - statistical analysis KW - salinity KW - satellite methods KW - ocean currents KW - tidal currents KW - measurement KW - tides KW - Georges Bank KW - Northeast Channel KW - seasonal variations KW - acoustic Doppler current profiler data KW - North Atlantic KW - Atlantic Ocean KW - Scotian Shelf KW - remote sensing KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51771843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Scotian+Shelf+crossovers+during+winter%2Fspring+1999&rft.au=Smith%2C+Peter+C%3BFlagg%2C+Charles+N%3BLimeburner%2C+Richard%3BFuentes-Yaco%2C+Cesar%3BHannah%2C+Charles%3BBeardsley%2C+Robert+C%3BIrish%2C+James+D%3BLee%2C+Craig+M&rft.aulast=Smith&rft.aufirst=Peter&rft.date=2003-11-01&rft.volume=108&rft.issue=C11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2001JC001288 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 27 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acoustic Doppler current profiler data; Atlantic Ocean; Browns Bank; currents; Georges Bank; measurement; North Atlantic; Northeast Channel; ocean circulation; ocean currents; remote sensing; salinity; satellite methods; Scotian Shelf; seasonal variations; statistical analysis; tidal currents; tides DO - http://dx.doi.org/10.1029/2001JC001288 ER - TY - JOUR T1 - Characterization of the mean and seasonal flow regime on Georges Bank from shipboard acoustic Doppler current profiler data AN - 51769938; 2005-002092 JF - Journal of Geophysical Research AU - Flagg, Charles N AU - Dunn, Maureen AU - Beardsley, Robert C AU - Smith, Peter C AU - Lee, Craig M Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 20 PB - American Geophysical Union, Washington, DC VL - 108 IS - C11 SN - 0148-0227, 0148-0227 KW - currents KW - ocean circulation KW - anticyclones KW - statistical analysis KW - ocean currents KW - least-squares analysis KW - tides KW - Great South Channel KW - Georges Bank KW - seasonal variations KW - acoustic Doppler current profiler data KW - North Atlantic KW - Atlantic Ocean KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51769938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Characterization+of+the+mean+and+seasonal+flow+regime+on+Georges+Bank+from+shipboard+acoustic+Doppler+current+profiler+data&rft.au=Flagg%2C+Charles+N%3BDunn%2C+Maureen%3BBeardsley%2C+Robert+C%3BSmith%2C+Peter+C%3BLee%2C+Craig+M&rft.aulast=Flagg&rft.aufirst=Charles&rft.date=2003-11-01&rft.volume=108&rft.issue=C11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2001JC001257 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 27 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch map, sect. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acoustic Doppler current profiler data; anticyclones; Atlantic Ocean; currents; Georges Bank; Great South Channel; least-squares analysis; North Atlantic; ocean circulation; ocean currents; seasonal variations; statistical analysis; tides DO - http://dx.doi.org/10.1029/2001JC001257 ER - TY - JOUR T1 - FTIR study of the effects of heterogeneity in water concentration on the origin of flow banded rhyolites AN - 51766584; 2004-085488 AB - This study focuses on the origin of flow-banded rhyolites that consist of darker and lighter flow bands that are not compositionally distinct magmas, but contrast in texture and color. Synchrotron-generated infrared radiation was used to obtain Fourier transform infrared (FTIR) spectra from which water concentrations were calculated, and to map variations in water concentrations across zones of spherules and glass from the 23 million year old Bartolo Mountain lava flow of southern Arizona. Lighter-colored, thicker flow bands consist of tan glass and large (2.5 to 5 mm) spherules. Darker-colored, thinner flow bands consist of brown glass and smaller (0.1 to 0.3 mm) spherules. Zones of orange glass separate lighter and darker flow bands. The center of the spherules is occupied by either 1) a quartz or sanidine crystal, 2) a granophyric intergrowth, or 3) (in some larger spherules) a void, suggesting that the spherule nucleated on a vapor bubble. In large spherules in the lighter bands, typically two zones of quartz/feldspar intergrowth radiate from the center of the spherule. The two zones are separated by a concentric zone of glass. Sanidine crystals that make up the cores of large spherules contain up to 250 ppm water. Inner radiating quartz/feldspar zones typically contain less ( approximately 2500 ppm) water than outer radiating quartz/feldspar zones ( approximately 3800 ppm). The transitional glass zones that separate the inner and outer zones contain to 7500 ppm water. Small spherules in darker bands have only one generation of radiating crystal growth. Water concentrations in small spherules range from a few hundred to approximately 1800 ppm. The orange glass that separates darker and lighter bands typically contains 1000-2000 ppm water. Overall the coarser-spherule, lighter-colored bands are much more water-rich than the finer-spherule, darker-colored bands, consistent with abundant water facilitating the growth of large spherules, and supporting the work of Hausback (1987), who suggested that flow banding may consist of alternating layers of stretched lithophysae, within which vapor phase crystallization occurred, and original less water-rich magma. Differences in original water concentration in the alternating layers resulted in differences in undercooling textures in spherules in the two types of flow bands. JF - Abstracts with Programs - Geological Society of America AU - Seaman, Sheila J AU - Dyar, M Darby AU - Marinkovic, Nebojsa AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 183 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - water KW - United States KW - rhyolites KW - petrology KW - Bartolo Mountain KW - volcanic rocks KW - textures KW - igneous rocks KW - infrared spectra KW - banded structures KW - FTIR spectra KW - mineral composition KW - Arizona KW - petrography KW - spectra KW - mineral assemblages KW - heterogeneity KW - flow texture KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51766584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=FTIR+study+of+the+effects+of+heterogeneity+in+water+concentration+on+the+origin+of+flow+banded+rhyolites&rft.au=Seaman%2C+Sheila+J%3BDyar%2C+M+Darby%3BMarinkovic%2C+Nebojsa%3BAnonymous&rft.aulast=Seaman&rft.aufirst=Sheila&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - Arizona; banded structures; Bartolo Mountain; flow texture; FTIR spectra; heterogeneity; igneous rocks; infrared spectra; mineral assemblages; mineral composition; petrography; petrology; rhyolites; spectra; textures; United States; volcanic rocks; water ER - TY - JOUR T1 - Effect of arsenic substitution on pyrite oxidation in bituminous coal samples; experiments and spectroscopic monitors AN - 51717143; 2005-039247 AB - Trace-constituent substitution in pyrite is an important factor that may affect its stability during oxidation of coal-bearing strata and waste from coal washing operations. Arsenic, the most abundant trace/minor constituent in pyrite, is thought to have a de-stabilizing effect, as indicated by previous XAFS studies showing oxidation of pyritic arsenic to arsenate in advance of significant iron oxidation. In this study, we exposed coal samples with differing amounts of pyrite and differing extents of arsenic substitution in pyrite, to controlled experimental conditions. Samples investigated include a Springfield coal from Indiana (whole coal pyritic S = 2.13 wt. %; As in pyrite=detection limit to 0.06 wt. %), two Pittsburgh coal samples from West Virginia (pyritic S = 1.32 to 1.58 wt. %; As in pyrite = d.l. to 0.34 wt. %), and two samples from the Warrior Basin, Alabama (pyritic S = 0.26 to 0.27 wt. %; As in pyrite = d.l. to 2.72 wt. %). Samples were collected from active mine faces and selected for expected differences in pyritic arsenic, confirmed by electron microprobe analysis. Splits of each sample are being exposed to four room-temperature experimental conditions over a period of 1-2 years, including: 1) dry argon atmosphere; 2) dry oxygen atmosphere; 3) room atmosphere (relative humidity approximately 20 to 60 %), and 4) room atmosphere with samples wetted periodically with double-distilled water. The extent of arsenic and iron oxidation is monitored by arsenic XAFS spectroscopy and iron Moessbauer spectroscopy. Arsenic XANES spectra for each coal sample, obtained after the first month of study, show major peaks for pyritic arsenic and minor peaks for arsenate forms. Least-squares fitting of the spectra shows little difference among equivalent samples stored under different atmospheres. However, the wetted samples showed significant formation of arsenate. Moessbauer spectroscopy also showed significant differences between samples stored under argon and those periodically wetted, but much less change with the other environments. The initial results show that arsenate formation can be induced and monitored, allowing comparison of oxidation progress in the test coal samples. JF - Abstracts with Programs - Geological Society of America AU - Kolker, Allan AU - Huggins, Frank E AU - Khalid, Syed AU - Fedorko, Nick AU - Mastalerz, Maria AU - Carroll, Richard E AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 482 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - United States KW - Pittsburgh Coal KW - Pennsylvanian KW - coal fields KW - environmental analysis KW - Alabama KW - bituminous coal KW - electron probe data KW - sedimentary rocks KW - mineral composition KW - sampling KW - coal KW - spectra KW - chemical composition KW - geochemistry KW - West Virginia KW - Mossbauer spectra KW - experimental studies KW - monitoring KW - pollutants KW - Paleozoic KW - oxidation KW - Warrior coal field KW - Carboniferous KW - arsenic KW - XAFS spectra KW - pollution KW - X-ray spectra KW - metals KW - pyrite KW - sulfides KW - 06B:Petrology of coal KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51717143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Effect+of+arsenic+substitution+on+pyrite+oxidation+in+bituminous+coal+samples%3B+experiments+and+spectroscopic+monitors&rft.au=Kolker%2C+Allan%3BHuggins%2C+Frank+E%3BKhalid%2C+Syed%3BFedorko%2C+Nick%3BMastalerz%2C+Maria%3BCarroll%2C+Richard+E%3BAnonymous&rft.aulast=Kolker&rft.aufirst=Allan&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2005-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - Alabama; arsenic; bituminous coal; Carboniferous; chemical composition; coal; coal fields; electron probe data; environmental analysis; experimental studies; geochemistry; metals; mineral composition; monitoring; Mossbauer spectra; oxidation; Paleozoic; Pennsylvanian; Pittsburgh Coal; pollutants; pollution; pyrite; sampling; sedimentary rocks; spectra; sulfides; United States; Warrior coal field; West Virginia; X-ray spectra; XAFS spectra ER - TY - JOUR T1 - Neuroimaging in drug abuse. AN - 73664627; 13678555 AB - Neuroimaging techniques, including positron emission tomography (PET), are ideally suited for studies of addiction. These minimally invasive modalities yield information about acute and long-term drug-induced structural and functional changes in the brain over time. Changes can be observed in the brains of human and animal subjects during drug self-administration. Neuroimaging with PET allows precise quantification and visualization of the drug and its rates of movement in the body. In addition, imaging reveals recovery of function and reappearance of neuronal markers in abstinent drug users. Evidence that suggests that PET may have use in identifying individuals predisposed to become addicted is emerging. Finally, candidate pharmacotherapies for drug addiction can be critically evaluated. These unique assets clearly point to the use of these strategies for addiction studies. JF - Current psychiatry reports AU - Lindsey, Kimberly P AU - Gatley, S John AU - Volkow, Nora D AD - Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY 11973, USA. lindsey@bnl.gov Y1 - 2003/10// PY - 2003 DA - October 2003 SP - 355 EP - 361 VL - 5 IS - 5 SN - 1523-3812, 1523-3812 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Tomography, Emission-Computed KW - Substance-Related Disorders -- therapy KW - Brain -- metabolism KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73664627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+psychiatry+reports&rft.atitle=Neuroimaging+in+drug+abuse.&rft.au=Lindsey%2C+Kimberly+P%3BGatley%2C+S+John%3BVolkow%2C+Nora+D&rft.aulast=Lindsey&rft.aufirst=Kimberly&rft.date=2003-10-01&rft.volume=5&rft.issue=5&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Current+psychiatry+reports&rft.issn=15233812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-06 N1 - Date created - 2003-09-18 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Low monoamine oxidase B in peripheral organs in smokers AN - 18882611; 5738599 AB - One of the major mechanisms for terminating the actions of catecholamines and vasoactive dietary amines is oxidation by monoamine oxidase (MAO). Smokers have been shown to have reduced levels of brain MAO, leading to speculation that MAO inhibition by tobacco smoke may underlie some of the behavioral and epidemiological features of smoking. Because smoking exposes peripheral organs as well as the brain to MAO-inhibitory compounds, we questioned whether smokers would also have reduced MAO levels in peripheral organs. Here we compared MAO B in peripheral organs in nonsmokers and smokers by using positron emission tomography and serial scans with the MAO B-specific radiotracers,L- [ super(11)C]deprenyl and deuterium-substituted L-[ super(11)C]deprenyl (L- [ super(11)C]deprenyl-D2). Binding specificity was assessed by using the deuterium isotope effect. We found that smokers have significantly reduced MAO B in peripheral organs, particularly in the heart, lungs, and kidneys, when compared with nonsmokers. Reductions ranged from 33% to 46%. Because MAO B breaks down catecholamines and other physiologically active amines, including those released by nicotine, its inhibition may alter sympathetic tone as well as central neurotransmitter activity, which could contribute to the medical consequences of smoking. In addition, although most of the emphases on the carcinogenic properties of smoke have been placed on the lungs and the upper airways, this finding highlights the fact that multiple organs in the body are also exposed to pharmacologically significant quantities of chemical compounds in tobacco smoke. JF - Proceedings of the National Academy of Sciences, USA AU - Fowler, J S AU - Logan, J AU - Wang, G-J AU - Volkow, N D AU - Telang, F AU - Zhu, W AU - Franceschi, D AU - Pappas, N AU - Ferrieri, R AU - Shea, C AU - Garza, V AU - Xu, Y AU - Schlyer, D AU - Gatley, S J AU - Ding, Y-S AU - Alexoff, D AU - Warner, D AU - Netusil, N AU - Carter, P AU - Jayne, M AU - King, P AU - Vaska, P AD - Chemistry Department and Medical Department, Brookhaven National Laboratory, Upton, NY 11973, fowler@bnl.gov Y1 - 2003/09/30/ PY - 2003 DA - 2003 Sep 30 SP - 11600 EP - 11605 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 100 IS - 20 SN - 0027-8424, 0027-8424 KW - man KW - Toxicology Abstracts KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18882611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Low+monoamine+oxidase+B+in+peripheral+organs+in+smokers&rft.au=Fowler%2C+J+S%3BLogan%2C+J%3BWang%2C+G-J%3BVolkow%2C+N+D%3BTelang%2C+F%3BZhu%2C+W%3BFranceschi%2C+D%3BPappas%2C+N%3BFerrieri%2C+R%3BShea%2C+C%3BGarza%2C+V%3BXu%2C+Y%3BSchlyer%2C+D%3BGatley%2C+S+J%3BDing%2C+Y-S%3BAlexoff%2C+D%3BWarner%2C+D%3BNetusil%2C+N%3BCarter%2C+P%3BJayne%2C+M%3BKing%2C+P%3BVaska%2C+P&rft.aulast=Fowler&rft.aufirst=J&rft.date=2003-09-30&rft.volume=100&rft.issue=20&rft.spage=11600&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1833106100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1073/pnas.1833106100 ER - TY - JOUR T1 - Role of Vitamin D receptor gene in radiation-induced neoplastic transformation of human breast epithelial cell. AN - 73622621; 12957667 AB - 1 Alpha,25-(OH)(2)-Vitamin D(3), the physiologically active metabolite of Vitamin D is known for its pro-differentiating and antiproliferative activity on various cancer cell lines. It exerts its growth-regulatory effects through binding to the Vitamin D recepter (VDR), a member of the steroid/thyroid/retinoic acid receptor family, which functions as a ligand-dependent transcription factor. There is accumulating evidence that Vitamin D may be an important determinant of both the occurrence and progression of breast cancer. Since radiation is an important etiological factor for breast cancer progression, it is important to study the role of VDR gene in radiation-induced breast carcinogenesis. This study is focused on a human breast tumor model developed by irradiating the spontaneously immortalized MCF-10F cell line with graded doses of high-linear energy transfer (LET) radiation followed by treatment with estrogen. Study of VDR gene by restriction digestion with ApaI, BsmI and TaqI detected no polymorphism but direct sequencing analyses identified few single-base mutations within intron 8 and exon 9 of the gene. Over-expression of the VDR gene was noticed in irradiated and tumorigenic cell lines compared with control. Likewise, immunohistochemical data indicated a significant increase in VDR intensity in irradiated and tumorigenic cell lines. Considering all these evidence, it is likely that VDR can be used as a prognostic marker of tumor progression in radiation- and estrogen-induced breast carcinogenesis. JF - Steroids AU - Roy, Debasish AU - Calaf, Gloria AU - Hei, Tom K AD - Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. droy@bnl.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 621 EP - 627 VL - 68 IS - 7-8 SN - 0039-128X, 0039-128X KW - Biomarkers, Tumor KW - 0 KW - Estrogens KW - Neoplasm Proteins KW - Receptors, Calcitriol KW - Index Medicus KW - Biomarkers, Tumor -- genetics KW - DNA Mutational Analysis KW - Humans KW - Prognosis KW - Mutation, Missense KW - Gene Expression Regulation, Neoplastic KW - Epithelial Cells -- chemistry KW - Estrogens -- pharmacology KW - Epithelial Cells -- pathology KW - Neoplasm Proteins -- genetics KW - Biomarkers, Tumor -- analysis KW - Cell Line, Transformed KW - Neoplasm Proteins -- analysis KW - Female KW - Receptors, Calcitriol -- genetics KW - Breast Neoplasms -- pathology KW - Breast Neoplasms -- diagnosis KW - Cell Transformation, Neoplastic -- radiation effects KW - Cell Transformation, Neoplastic -- chemistry KW - Receptors, Calcitriol -- analysis KW - Breast Neoplasms -- etiology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73622621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Steroids&rft.atitle=Role+of+Vitamin+D+receptor+gene+in+radiation-induced+neoplastic+transformation+of+human+breast+epithelial+cell.&rft.au=Roy%2C+Debasish%3BCalaf%2C+Gloria%3BHei%2C+Tom+K&rft.aulast=Roy&rft.aufirst=Debasish&rft.date=2003-09-01&rft.volume=68&rft.issue=7-8&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Steroids&rft.issn=0039128X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-26 N1 - Date created - 2003-09-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Security Risk Analysis for Chemical Process Facilities AN - 19140772; 5749743 AB - In response to the events of September 11, many companies stepped up security efforts in chemical process facilities and other installations. Since resources are limited, a system for ranking relative risk would be useful in establishing priorities for implementing physical-security infrastructure and programs. This paper presents the elements of a relative risk assessment that can augment conventional process hazard analysis (PHA). This assessment is based on categorizing threat, vulnerability, and the consequences of deliberate actions by terrorists, disgruntled employees, and others. JF - Process Safety Progress AU - Lemley, J R AU - Fthenakis, V M AU - Moskowitz, P D AD - Brookhaven National Laboratory, Building 830, P.O. Box 5000, Upton, NY 11973-5000, USA, vmf@bnl.gov Y1 - 2003/09// PY - 2003 DA - Sep 2003 SP - 153 EP - 162 VL - 22 IS - 3 SN - 0278-4513, 0278-4513 KW - security KW - terrorism KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Chemical process industry KW - Emergency preparedness KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19140772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Process+Safety+Progress&rft.atitle=Security+Risk+Analysis+for+Chemical+Process+Facilities&rft.au=Lemley%2C+J+R%3BFthenakis%2C+V+M%3BMoskowitz%2C+P+D&rft.aulast=Lemley&rft.aufirst=J&rft.date=2003-09-01&rft.volume=22&rft.issue=3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Process+Safety+Progress&rft.issn=02784513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chemical process industry; Emergency preparedness; Risk assessment ER - TY - JOUR T1 - Nesting Ecology and Predation of Diamondback Terrapins, Malaclemys terrapin, at Gateway National Recreation Area, New York AN - 18938205; 5712597 AB - We studied Diamondback terrapins, Malaclemys terrapin, at Gateway National Recreation Area, New York. We found evidence of nesting terrapins at three locations within the Recreation Area and focused our research on the islands of Jamaica Bay Wildlife Refuge. Female terrapins nested from early June through early August and oviposited at least two clutches per year. Mean clutch size was 10.9 eggs. Nesting activity increased with daily high temperature and high tide. The greatest number of terrapin nests was found in shrubland, dune, and mixed-grassland habitats, but nest densities were higher on a human-made sandy trail and on sandy beaches. We estimate that approximately 2053 nests were oviposited on the largest island in the refuge in 1999. In 1998 and 1999, we counted 1319 and 1840 depredated nests, respectively, throughout the refuge. Raccoons were introduced into Jamaica Bay Wildlife Refuge approximately 20 yr prior to this study. Raccoons depredated 92.2% of nests monitored on the largest island during the 1999 nesting season. We also found the carcasses of adult female terrapins that apparently were killed by raccoons as they came on land to nest. This terrapin population may be undergoing demographic changes as a result of the introduction of raccoons. JF - Journal of Herpetology AU - Feinberg, JA AU - Burke, R L AD - U.S. Fish and Wildlife Service, Brookhaven National Laboratory, 81 Cornell Avenue, Building 120, Upton, New York 11973, USA, jfeinberg@bnl.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 517 EP - 526 PB - The Society for the Study of Amphibians and Reptiles VL - 37 IS - 3 SN - 0022-1511, 0022-1511 KW - Diamondback terrapin KW - Raccoon KW - ASFA 1: Biological Sciences & Living Resources; Animal Behavior Abstracts; Ecology Abstracts KW - Nesting behavior KW - Beaches KW - Recreation sites KW - Predation KW - Aquatic reptiles KW - Predators KW - Freshwater KW - USA, New York, Long I., Jamaica Bay, Jamaica Bay Natl. Wildlife refuge KW - USA, New York KW - Islands KW - Malaclemys terrapin KW - Breeding sites KW - Nesting KW - Procyon lotor KW - Reproductive behaviour KW - Introduced species KW - USA, New York, Gateway Natl. Recreation area KW - Y 25424:Vertebrates (excluding fish, birds & mammals) KW - Q1 08423:Behaviour KW - D 04670:Reptiles KW - Q1 08324:Reproduction and development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18938205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Herpetology&rft.atitle=Nesting+Ecology+and+Predation+of+Diamondback+Terrapins%2C+Malaclemys+terrapin%2C+at+Gateway+National+Recreation+Area%2C+New+York&rft.au=Feinberg%2C+JA%3BBurke%2C+R+L&rft.aulast=Feinberg&rft.aufirst=JA&rft.date=2003-09-01&rft.volume=37&rft.issue=3&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+Herpetology&rft.issn=00221511&rft_id=info:doi/10.1043%2F0022-1511%282003%29037%280517%3ANEAPOD%292.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Beaches; Islands; Breeding sites; Nesting; Aquatic reptiles; Predators; Reproductive behaviour; Introduced species; Nesting behavior; Recreation sites; Predation; Malaclemys terrapin; Procyon lotor; USA, New York, Long I., Jamaica Bay, Jamaica Bay Natl. Wildlife refuge; USA, New York, Gateway Natl. Recreation area; USA, New York; Freshwater DO - http://dx.doi.org/10.1043/0022-1511(2003)037(0517:NEAPOD)2.0.CO;2 ER - TY - JOUR T1 - Abnormal brain activation to visual stimulation in cocaine abusers. AN - 73537160; 12899920 AB - Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level dependent] responses to activation stimuli. Here, we used fMRI to compared the BOLD response to photic visual stimulation in neurologically intact active cocaine abusers to that in non-drug-using healthy controls. Cocaine abusers showed a significantly enhanced positive BOLD response to photic stimulation when compared to control subjects. The enhanced activation in the cocaine abusers could result from low resting cerebral blood flow secondary to increased vasoconstriction and/or from low oxidative metabolism during activation. Alternatively, the larger signal intensity in the cocaine abusers could result from inefficient neuronal processing as has been shown to occur in other conditions of cerebral pathology. These findings provide evidence of cerebral dysfunction with chronic cocaine abuse, which could reflect cerebral blood flow or neuronal changes. Further studies are required to determine if the cerebrovascular changes we observed in the cocaine abusers recover with detoxification and to assess their functional consequences. JF - Life sciences AU - Lee, Jing-Huei AU - Telang, Frank W AU - Springer, Charles S AU - Volkow, Nora D AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2003/08/29/ PY - 2003 DA - 2003 Aug 29 SP - 1953 EP - 1961 VL - 73 IS - 15 SN - 0024-3205, 0024-3205 KW - Narcotics KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Photic Stimulation KW - Brain Mapping KW - Visual Cortex -- physiology KW - Evoked Potentials, Visual KW - Oxygen -- blood KW - Humans KW - Blood Flow Velocity -- drug effects KW - Adult KW - Visual Cortex -- blood supply KW - Middle Aged KW - Magnetic Resonance Angiography -- methods KW - Image Processing, Computer-Assisted KW - Male KW - Cocaine-Related Disorders -- diagnosis KW - Cerebrovascular Circulation -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Narcotics -- adverse effects KW - Cocaine-Related Disorders -- blood KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73537160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Abnormal+brain+activation+to+visual+stimulation+in+cocaine+abusers.&rft.au=Lee%2C+Jing-Huei%3BTelang%2C+Frank+W%3BSpringer%2C+Charles+S%3BVolkow%2C+Nora+D&rft.aulast=Lee&rft.aufirst=Jing-Huei&rft.date=2003-08-29&rft.volume=73&rft.issue=15&rft.spage=1953&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-03 N1 - Date created - 2003-08-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Response of rat skin to high-dose unidirectional x-ray microbeams: a histological study. AN - 73479435; 12859223 AB - There is growing interest in evaluating microbeam radiation therapy as a potential clinical modality. Microbeam radiation therapy uses arrays of parallel, microscopically thin (<100 microm) planes of synchrotron-generated X rays (microplanar beams, or microbeams). Due to the relatively low beam energies involved in microbeam radiation therapy (a median beam energy of 120 keV was used in the present study), the dose penetration of microbeams in tissue is lower than that used in conventional radiotherapy. This lower energy necessitates using a significantly elevated dose to the skin's surface during clinical microbeam therapy to ensure an adequate dose distribution in the target tumor. The findings of the present study, using a rat skin model, indicated that the skin had an extremely high tolerance to microbeam radiation at doses considerably in excess of those that were therapeutically effective in preclinical studies. A histological study was undertaken to evaluate the biological mechanisms underlying this high tolerance. The irradiation configuration employed single-exposure, unidirectional microbeams 90 microm wide, with 300 microm beam spacing on-center. The in-beam skin-surface absorbed doses were in the range 835-1335 Gy. Monte Carlo simulations of the dose distribution indicated that the "valley" dose, i.e. the radiation leakage between adjacent microbeams, was about 2.5% of the in-beam dose. The high tolerance of the rats' skin to microbeams and the rapid regeneration of the damaged segments of skin were attributed to the surviving clonogenic cells situated between the adjacent microplanar beams. In the epidermis, clonogenic cells in the hair follicular epithelium appeared to play a key role in the regeneration process. JF - Radiation research AU - Zhong, Nan AU - Morris, Gerard M AU - Bacarian, Tigran AU - Rosen, Eliot M AU - Dilmanian, F Avraham AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 133 EP - 142 VL - 160 IS - 2 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Animals KW - Radiation Dosage KW - Reference Values KW - Hindlimb -- cytology KW - Epidermis -- cytology KW - Radiation Tolerance KW - Dose-Response Relationship, Radiation KW - Rats KW - X-Rays KW - Rats, Inbred F344 KW - Hair Follicle -- radiation effects KW - Hair Follicle -- cytology KW - Hindlimb -- radiation effects KW - Epidermis -- radiation effects KW - Male KW - Skin -- radiation effects KW - Skin -- pathology KW - Skin -- cytology KW - Radiometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73479435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Response+of+rat+skin+to+high-dose+unidirectional+x-ray+microbeams%3A+a+histological+study.&rft.au=Zhong%2C+Nan%3BMorris%2C+Gerard+M%3BBacarian%2C+Tigran%3BRosen%2C+Eliot+M%3BDilmanian%2C+F+Avraham&rft.aulast=Zhong&rft.aufirst=Nan&rft.date=2003-08-01&rft.volume=160&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-08 N1 - Date created - 2003-07-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - A crystal structure for the souzalite/gormanite series from synchrotron powder diffraction data AN - 51937472; 2003-070564 AB - In absence of suitable single crystal due to polysynthetic twinning, the crystal structure of a specimen in the souzalite/gormanite series (Fe,Mg) (sub 3) (Al,Fe) (sub 4) (PO (sub 4) ) (sub 4) (OH) (sub 6) .2H (sub 2) O is determined ab initio from synchrotron powder diffraction data. The crystals belong to space group P1, the cell is different from previously reported with a = 7.2223(1), b = 11.7801(1), c = 5.1169(1) Aa; alpha = 90.158(1), beta = 109.938(1), gamma = 81.330(1) degrees ; V = 404.02(1) Aa (super 3) ; Z = 1. The structure consists of infinite chains of alternating [FeO (sub 6) ], [MgO (sub 6) ] and [AlO (sub 6) ] octahedra sharing faces and/or edges. These chains are connected by corners with clusters of three corner-sharing [AlO (sub 6) ] octahedra, forming octahedral layers which are interconnected by [PO (sub 4) ] groups. A comparison with other minerals of similar composition and structure is made (dufrenite, burangaite). JF - European Journal of Mineralogy AU - Le Bail, Armel AU - Stephens, Peter W AU - Hubert, Francis Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 719 EP - 723 PB - Schweizerbart'sche Verlagsbuchhandlung (Naegele u. Obermiller), Stuttgart VL - 15 IS - 4 SN - 0935-1221, 0935-1221 KW - X-ray diffraction data KW - unit cell KW - souzalite KW - crystal structure KW - phosphates KW - bonding KW - Yukon Territory KW - Rietveld refinement KW - gormanite KW - synchrotron radiation KW - hydroxyl ion KW - Canada KW - Rapid Creek Yukon Territory KW - Western Canada KW - lattice parameters KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Mineralogy&rft.atitle=A+crystal+structure+for+the+souzalite%2Fgormanite+series+from+synchrotron+powder+diffraction+data&rft.au=Le+Bail%2C+Armel%3BStephens%2C+Peter+W%3BHubert%2C+Francis&rft.aulast=Le+Bail&rft.aufirst=Armel&rft.date=2003-08-01&rft.volume=15&rft.issue=4&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Mineralogy&rft.issn=09351221&rft_id=info:doi/10.1127%2F0935-1221%2F2003%2F0015-0719 L2 - http://www.schweizerbart.de/j/ejm/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 13 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bonding; Canada; crystal structure; gormanite; hydroxyl ion; lattice parameters; phosphates; Rapid Creek Yukon Territory; Rietveld refinement; souzalite; synchrotron radiation; unit cell; Western Canada; X-ray diffraction data; Yukon Territory DO - http://dx.doi.org/10.1127/0935-1221/2003/0015-0719 ER - TY - JOUR T1 - Increased plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung and breast cancer are altered during chest radiotherapy. AN - 73418758; 12829155 AB - PURPOSEDoes the release of plasma matrix metalloproteinase-9 (MMP-9) by radiation-activated airway epithelial cells and infiltrating inflammatory cells play a role in the radiation damage or repair process in the lungs? We evaluated lung damage by ionizing radiation using plasma levels of MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), and MMP-3 as biologic markers of tissue damage, and also their relationship to changes in pulmonary epithelial permeability, clinical signs and symptoms, and lung structural changes.METHODS AND MATERIALSSeven serial studies were conducted in each of 8 patients undergoing chest radiotherapy (RT) for lung or breast cancer, beginning before the first treatment (baseline) and then biweekly to approximately 100 days during and after RT. Chest radiographs were monitored for each patient. Sandwich enzyme-linked immunoassays (ELISA) were used to measure plasma MMP-3, MMP-9, and TIMP-1 levels. Lung permeability was evaluated by measuring the rate of epithelial clearance of approximately 150 microCi ( approximately 5.6 MBq) inhaled (99m)Tc diethylenetriamine pentaacetate aerosol (DTPA).RESULTSLung and breast cancer resulted in very high plasma levels of MMP-9 (126-893 ng/mL) and TIMP-1 (496-8985 ng/mL) in all subjects studied before initiation of RT. This compares with plasma MMP-9 and TIMP-1 values in healthy volunteers of 29 +/- 11 ng/mL and 436 +/- 86 ng/mL, respectively. RT was followed by a sharp decrease in plasma MMP-9 within the first 2 weeks, but without a corresponding change in TIMP-1. In contrast, plasma MMP-3 levels, which are generally increased with inflammation, were elevated in only 1 of 5 subjects.CONCLUSIONLung and breast cancer are associated with high plasma levels of MMP-9 and TIMP-1. These high baseline plasma levels of MMP-9 were reduced in the first 2 weeks of RT in 7 of 8 subjects, and TIMP-1 plasma levels remained high in all subjects. The decrease in plasma MMP-9 after initiation of chest RT appears to reflect a suppressive effect on cancer-induced cellular responses rather than a primary role for MMP-9 in radiation-induced lung damage. Likewise, the lack of a rise in plasma MMP-3 levels does not support a role for MMP-3 in tissue injury or repair in the lung. It remains to be determined whether plasma MMP-9 measurements will serve as a useful parameter in predicting cancer relapse. JF - International journal of radiation oncology, biology, physics AU - Susskind, Herbert AU - Hymowitz, Michelle H AU - Lau, Yat Hong AU - Atkins, Harold L AU - Hurewitz, Adam N AU - Valentine, Edward S AU - Meek, Allen G AU - Zucker, Stanley AD - Clinical Research Center, Brookhaven National Laboratory, Upton, NY 11973, USA. Hssusski@optonline.net Y1 - 2003/07/15/ PY - 2003 DA - 2003 Jul 15 SP - 1161 EP - 1169 VL - 56 IS - 4 SN - 0360-3016, 0360-3016 KW - Tissue Inhibitor of Metalloproteinase-1 KW - 0 KW - Matrix Metalloproteinase 3 KW - EC 3.4.24.17 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Technetium Tc 99m Pentetate KW - VW78417PU1 KW - Index Medicus KW - Lung -- diagnostic imaging KW - Humans KW - Aged KW - Lung -- metabolism KW - Radiation Injuries -- blood KW - Radiotherapy -- adverse effects KW - Radionuclide Imaging KW - Epithelial Cells -- radiation effects KW - Epithelial Cells -- metabolism KW - Radiation Injuries -- diagnostic imaging KW - Technetium Tc 99m Pentetate -- pharmacokinetics KW - Cell Membrane Permeability -- radiation effects KW - Middle Aged KW - Radiography KW - Matrix Metalloproteinase 3 -- blood KW - Radiation Injuries -- enzymology KW - Female KW - Male KW - Lung -- radiation effects KW - Lung Neoplasms -- enzymology KW - Lung Neoplasms -- radiotherapy KW - Matrix Metalloproteinase 9 -- blood KW - Lung Neoplasms -- blood KW - Tissue Inhibitor of Metalloproteinase-1 -- blood KW - Breast Neoplasms -- enzymology KW - Breast Neoplasms -- radiotherapy KW - Breast Neoplasms -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73418758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Increased+plasma+levels+of+matrix+metalloproteinase-9+and+tissue+inhibitor+of+metalloproteinase-1+in+lung+and+breast+cancer+are+altered+during+chest+radiotherapy.&rft.au=Susskind%2C+Herbert%3BHymowitz%2C+Michelle+H%3BLau%2C+Yat+Hong%3BAtkins%2C+Harold+L%3BHurewitz%2C+Adam+N%3BValentine%2C+Edward+S%3BMeek%2C+Allen+G%3BZucker%2C+Stanley&rft.aulast=Susskind&rft.aufirst=Herbert&rft.date=2003-07-15&rft.volume=56&rft.issue=4&rft.spage=1161&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-31 N1 - Date created - 2003-06-27 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine. AN - 73508670; 12684739 AB - RATIONALEgamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism.OBJECTIVESGiven its preclinical success for treating substance abuse and the increased risk of visual field defects (VFD) associated with cumulative lifetime exposure, we explored the effects of sub-chronic low dose GVG on cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA).METHODSUsing in vivo microdialysis, we compared acute exposure (450 mg/kg) to an identical sub-chronic exposure (150 mg/kg per day for 3 days), followed by 1- or 3-day washout. Finally, we examined the low dose of 150 mg/kg (50 mg/kg per day) using a similar washout period.RESULTSSub-chronic GVG exposure inhibited the effect of cocaine for 3 days, which exceeded in magnitude and duration the identical acute dose.CONCLUSIONSSub-chronic low dose GVG potentiates and extends the inhibition of cocaine-induced increases in dopamine, effectively reducing cumulative exposures and the risk for VFDS. JF - Psychopharmacology AU - Schiffer, Wynne K AU - Marsteller, Douglas AU - Dewey, Stephen L AD - Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA. wynne@bnl.gov Y1 - 2003/07// PY - 2003 DA - July 2003 SP - 339 EP - 343 VL - 168 IS - 3 SN - 0033-3158, 0033-3158 KW - 4-Aminobutyrate Transaminase KW - EC 2.6.1.19 KW - Vigabatrin KW - GR120KRT6K KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Microdialysis KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Time Factors KW - Male KW - Vigabatrin -- pharmacology KW - Nucleus Accumbens -- drug effects KW - 4-Aminobutyrate Transaminase -- antagonists & inhibitors KW - Vigabatrin -- administration & dosage KW - Cocaine-Related Disorders -- drug therapy KW - Nucleus Accumbens -- metabolism KW - Dopamine -- metabolism KW - Cocaine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73508670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Sub-chronic+low+dose+gamma-vinyl+GABA+%28vigabatrin%29+inhibits+cocaine-induced+increases+in+nucleus+accumbens+dopamine.&rft.au=Schiffer%2C+Wynne+K%3BMarsteller%2C+Douglas%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2003-07-01&rft.volume=168&rft.issue=3&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-10 N1 - Date created - 2003-07-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Could X-ray microbeams inhibit angioplasty-induced restenosis in the rat carotid artery? AN - 71550505; 14984714 AB - BACKGROUNDParallel, thin (<100 microm) planes of synchrotron-generated X rays, have been shown to spare normal tissues and preferentially damage tumors in animal models. The aim of the present study was to assess the effect of such microbeams directed unidirectionally on angioplasted rat carotid arteries.METHODS AND MATERIALSThree groups of Sprague-Dawley rats were studied: (a) rats with normal, untreated arteries, (b) rats treated by balloon angioplasty, but not irradiated, and (c) rats treated with balloon angioplasty and exposed to single fraction, unidirectional, parallel, microbeams an hour after angioplasty. The microbeam array, 15 mm widex7.6 mm high, consisting of 27-microm-wide beam slices, spaced 200 microm center-to-center laterally traversed the damaged artery. The in-depth in-beam dose was 150 Gy, the "valley" dose (dose midway between microbeams resulting mainly from X-ray scattering) was 4.5 Gy on average, and the "integrated" (averaged) dose was 26 Gy.RESULTSMicrobeam irradiation, as given in the present study, was tolerated, but was insufficient to significantly suppress the neointimal hyperplasia.DISCUSSIONThe microbeam dose used is considered low. Dose escalation would be necessary to reach conclusive results regarding the X-ray microbeam efficacy to control restenosis. JF - Cardiovascular radiation medicine AU - Dilmanian, F A AU - Kalef-Ezra, J AU - Petersen, M J AU - Bozios, G AU - Vosswinkel, J AU - Giron, F AU - Ren, B AU - Yakupov, R AU - Antonakopoulos, G AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. PY - 2003 SP - 139 EP - 145 VL - 4 IS - 3 SN - 1522-1865, 1522-1865 KW - Index Medicus KW - Rats KW - Models, Cardiovascular KW - Animals KW - X-Rays KW - Rats, Sprague-Dawley KW - Tunica Intima -- radiation effects KW - Hyperplasia -- etiology KW - Disease Models, Animal KW - Dose-Response Relationship, Radiation KW - Tunica Intima -- pathology KW - Hyperplasia -- radiotherapy KW - Carotid Artery, Common -- radiation effects KW - Carotid Artery, Common -- pathology KW - Angioplasty, Balloon -- adverse effects KW - Carotid Stenosis -- therapy KW - Graft Occlusion, Vascular -- etiology KW - Carotid Artery, Common -- surgery KW - Graft Occlusion, Vascular -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71550505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+radiation+medicine&rft.atitle=Could+X-ray+microbeams+inhibit+angioplasty-induced+restenosis+in+the+rat+carotid+artery%3F&rft.au=Dilmanian%2C+F+A%3BKalef-Ezra%2C+J%3BPetersen%2C+M+J%3BBozios%2C+G%3BVosswinkel%2C+J%3BGiron%2C+F%3BRen%2C+B%3BYakupov%2C+R%3BAntonakopoulos%2C+G&rft.aulast=Dilmanian&rft.aufirst=F&rft.date=2003-07-01&rft.volume=4&rft.issue=3&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+radiation+medicine&rft.issn=15221865&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-08 N1 - Date created - 2004-02-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Evidence linking the Pseudomonas oleovorans alkane omega-hydroxylase, an integral membrane diiron enzyme, and the fatty acid desaturase family. AN - 73376494; 12804773 AB - Pseudomonas oleovorans alkane omega-hydroxylase (AlkB) is an integral membrane diiron enzyme that shares a requirement for iron and oxygen for activity in a manner similar to that of the non-heme integral membrane desaturases, epoxidases, acetylenases, conjugases, ketolases, decarbonylase and methyl oxidases. No overall sequence similarity is detected between AlkB and these desaturase-like enzymes by computer algorithms; however, they do contain a series of histidine residues in a similar relative positioning with respect to hydrophobic regions thought to be transmembrane domains. To test whether these conserved histidine residues are functionally equivalent to those of the desaturase-like enzymes we used scanning alanine mutagenesis to test if they are essential for activity of AlkB. These experiments show that alanine substitution of any of the eight conserved histidines results in complete inactivation, whereas replacement of three non-conserved histidines in close proximity to the conserved residues, results in only partial inactivation. These data provide the first experimental support for the hypotheses: (i) that the histidine motif in AlkB is equivalent to that in the desaturase-like enzymes and (ii) that the conserved histidine residues play a vital role such as coordinating the Fe ions comprising the diiron active site. JF - FEBS letters AU - Shanklin, John AU - Whittle, Edward AD - Department of Biology, Brookhaven National Laboratory, Building 463, 50 Bell Ave., Upton, NY 11973, USA. shanklin@bnl.gov Y1 - 2003/06/19/ PY - 2003 DA - 2003 Jun 19 SP - 188 EP - 192 VL - 545 IS - 2-3 SN - 0014-5793, 0014-5793 KW - Bacterial Proteins KW - 0 KW - Membrane Proteins KW - Histidine KW - 4QD397987E KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Iron KW - E1UOL152H7 KW - Mixed Function Oxygenases KW - EC 1.- KW - Cytochrome P-450 CYP4A KW - EC 1.14.15.3 KW - Fatty Acid Desaturases KW - EC 1.14.19.- KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Histidine -- chemistry KW - Pseudomonas -- enzymology KW - Conserved Sequence KW - Amino Acid Motifs KW - Alanine -- metabolism KW - Histidine -- genetics KW - Point Mutation KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Amino Acid Substitution KW - Bacterial Proteins -- genetics KW - Mixed Function Oxygenases -- metabolism KW - Fatty Acid Desaturases -- chemistry KW - Fatty Acid Desaturases -- genetics KW - Bacterial Proteins -- chemistry KW - Membrane Proteins -- chemistry KW - Membrane Proteins -- metabolism KW - Fatty Acid Desaturases -- metabolism KW - Bacterial Proteins -- metabolism KW - Iron -- chemistry KW - Cytochrome P-450 Enzyme System -- metabolism KW - Membrane Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73376494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Evidence+linking+the+Pseudomonas+oleovorans+alkane+omega-hydroxylase%2C+an+integral+membrane+diiron+enzyme%2C+and+the+fatty+acid+desaturase+family.&rft.au=Shanklin%2C+John%3BWhittle%2C+Edward&rft.aulast=Shanklin&rft.aufirst=John&rft.date=2003-06-19&rft.volume=545&rft.issue=2-3&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-25 N1 - Date created - 2003-06-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Alcohol intoxication induces greater reductions in brain metabolism in male than in female subjects. AN - 73419104; 12824811 AB - BACKGROUNDThe mechanisms underlying the gender differences in alcohol drinking behavior and alcohol's effects are poorly understood and may reflect gender differences in brain neurochemistry. Alcohol decreases glucose metabolism in the human brain in a pattern that is consistent with its facilitation of GABAergic neurotransmission. We compared the regional changes in brain glucose metabolism during alcohol intoxication between female and male subjects.METHODSTen female and 10 male healthy controls were scanned with positron emission tomography and 2-deoxy-2[18F]fluoro-D-glucose twice: 40 min after placebo (diet soda) or alcohol (0.75 g/kg mixed with diet soda).RESULTSAlcohol significantly and consistently decreased whole-brain metabolism. The magnitude of these changes was significantly larger in male (-25 +/- 6%) than in female (-14 +/- 11%; p < 0.005) subjects. Half of the female subjects had reductions in metabolism during intoxication that were significantly lower than those in male subjects. This blunted response in the female subjects was not due to differences in alcohol concentration in plasma, because these did not differ between the genders. In contrast, the self-reports for the perception of intoxication were significantly greater in female than in male subjects. The cognitive deterioration during alcohol intoxication, although not significant, tended to be worse in female subjects.CONCLUSIONSThis study shows a markedly blunted sensitivity to the effects of acute alcohol on brain glucose metabolism in female subjects that may reflect gender differences in alcohol's modulation of GABAergic neurotransmission. The greater behavioral effects of alcohol in female subjects despite the blunted metabolic responses could reflect other effects of alcohol, for which the regional metabolic signal may be hidden within the large decrements in metabolism that occur during alcohol intoxication. JF - Alcoholism, clinical and experimental research AU - Wang, Gene-Jack AU - Volkow, Nora D AU - Fowler, Joanna S AU - Franceschi, Dinko AU - Wong, Christopher T AU - Pappas, Naomi R AU - Netusil, Noelwah AU - Zhu, Wei AU - Felder, Christoph AU - Ma, Yeming AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. gjwang@bnl.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 909 EP - 917 VL - 27 IS - 6 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Analysis of Variance KW - Humans KW - Adult KW - Middle Aged KW - Statistics, Nonparametric KW - Male KW - Female KW - Tomography, Emission-Computed -- methods KW - Sex Characteristics KW - Brain -- drug effects KW - Brain -- metabolism KW - Alcoholic Intoxication -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73419104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcohol+intoxication+induces+greater+reductions+in+brain+metabolism+in+male+than+in+female+subjects.&rft.au=Wang%2C+Gene-Jack%3BVolkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BFranceschi%2C+Dinko%3BWong%2C+Christopher+T%3BPappas%2C+Naomi+R%3BNetusil%2C+Noelwah%3BZhu%2C+Wei%3BFelder%2C+Christoph%3BMa%2C+Yeming&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2003-06-01&rft.volume=27&rft.issue=6&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-21 N1 - Date created - 2003-06-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Neutron and temperature-resolved synchrotron X-ray powder diffraction study of akaganeite AN - 51961496; 2003-051817 AB - Rietveld refinements using neutron powder diffraction data were used to locate H atom positions and obtain a more precise crystal structure refinement for akaganeite [Fe (super 3+) (sub 7.6) Ni (super 2+) (sub 0.4) O (sub 6.35) (OH) (sub 9.65) Cl (sub 1.25) .nH (sub 2) O]. Difference Fourier maps clearly showed H atoms positions near those O atoms at the midpoints of the tunnel edges. The O-H vectors point toward the Cl sites at the center of the tunnel, and weak hydrogen bonds likely form between the framework O atoms and Cl. The Cl position is near the center of a prism defined by the eight hydroxy1 H atoms. The Cl atoms fill approximately 2/3 of the tunnel sites, suggesting an ordering scheme in a given tunnel with every third tunnel site vacant. Such an arrangement allows the Cl anions to increase their separation distance along a tunnel by displacing away from one another toward their respective adjacent vacancies. The Fe-O octahedra in akaganeite are distorted with Fe-(O, OH) distances ranging from 1.94 to 2.13 Aa and show three longer and three shorter Fe-O distances; as expected the longer distances are associated with the OH-anions. Temperature-resolved synchrotron X-ray powder diffraction data and Rietveld refinements were used to investigate changes in the akaganeite structure and its transformation into hematite as it was heated from 26 to 800 degrees C. Rietveld refinements revealed surprising consistency in all unit-cell parameters between room temperature and approximately 225 degrees C, resulting in nearly zero thermal expansion of the akaganeite structure over a 200 degrees C interval. Above approximately 225 degrees C, the unit-cell volume gradually decreased, primarily in response to decreases in c and b, and an increase in the beta angle. The a parameter remained nearly constant until approximately 225 degrees C and increased thereafter. Akaganeite started to transform to hematite in the temperature range 290 to 310 degrees C with no evidence for maghemite as an intermediate phase. JF - American Mineralogist AU - Post, Jeffrey E AU - Heaney, Peter J AU - Von Dreele, Robert B AU - Hanson, Jonathan C Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 782 EP - 788 PB - Mineralogical Society of America, Washington, DC VL - 88 IS - 5-6 SN - 0003-004X, 0003-004X KW - refinement KW - X-ray diffraction data KW - akaganeite KW - unit cell KW - oxides KW - crystal structure KW - bonding KW - Rietveld refinement KW - P-T conditions KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51961496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Neutron+and+temperature-resolved+synchrotron+X-ray+powder+diffraction+study+of+akaganeite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+Peter+J%3BVon+Dreele%2C+Robert+B%3BHanson%2C+Jonathan+C&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2003-06-01&rft.volume=88&rft.issue=5-6&rft.spage=782&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 26 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - akaganeite; bonding; crystal structure; oxides; P-T conditions; refinement; Rietveld refinement; unit cell; X-ray diffraction data ER - TY - JOUR T1 - Highlights of PET studies on chiral radiotracers and drugs at Brookhaven AN - 20641635; 7761733 AB - We review several PET studies of chiral molecules which have been carried out in our laboratory. In many cases the enantiomers behave differently, reflecting factors such as differential specificity for enzymes and transporters and binding to plasma proteins, as well as selective binding to receptors. These studies demonstrate that PET imaging is a suitable method to investigate the behavior of a chiral drug in the human body and is a powerful tool in drug development. It is important to emphasize the essential and pivotal role that organic synthesis has played in the development of PET during the last quarter century. PET is now an important tool in the neurosciences, cardiology, and oncology and is available in hundreds of institutions worldwide. However, PET is by no means mature in terms of the study of chiral drugs; hundreds of racemic drugs have been developed but only a few have been labeled with positron emitters to study their stereoselectivity. One reason is the complexity of rapid synthesis, including chiral synthesis and chiral purification. New developments in these areas are needed. Although PET is a challenging and expensive technology, it is exquisitely suited to functional and neurochemical studies of the human brain and other organs. Its use in drug research and development holds promise in understanding duration of action and stereoselectivity of drugs and in facilitating drug discovery and the introduction of new drugs into the practice of medicine. JF - Drug Development Research AU - Ding, Yu-Shin AU - Fowler, Joanna S AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York, ding@bnl.gov Y1 - 2003/06// PY - 2003 DA - Jun 2003 SP - 227 EP - 239 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 59 IS - 2 SN - 0272-4391, 0272-4391 KW - Biotechnology Research Abstracts (through 1992) KW - Plasma proteins KW - Drug discovery KW - Neuroimaging KW - Enantiomers KW - Brain KW - Positron emission tomography KW - Enzymes KW - Oncology KW - Drug development KW - Stereoselectivity KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20641635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Development+Research&rft.atitle=Highlights+of+PET+studies+on+chiral+radiotracers+and+drugs+at+Brookhaven&rft.au=Ding%2C+Yu-Shin%3BFowler%2C+Joanna+S&rft.aulast=Ding&rft.aufirst=Yu-Shin&rft.date=2003-06-01&rft.volume=59&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Drug+Development+Research&rft.issn=02724391&rft_id=info:doi/10.1002%2Fddr.10221 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Positron emission tomography; Drug development; Stereoselectivity; Drug discovery; Plasma proteins; Neuroimaging; Brain; Enzymes; Enantiomers; Oncology DO - http://dx.doi.org/10.1002/ddr.10221 ER - TY - JOUR T1 - Positron emission tomography and its use to image the occupancy of drug binding sites AN - 20416914; 7761731 AB - The development of positron emission tomography (PET) and the ability to synthesize compounds labeled with the short-lived positron emitters 11C and 18F has made possible the imaging and quantification of drug binding sites in the human body. By conducting PET studies with an appropriate radioligand iefore and after treatment with a drug, the fraction of the total number of binding sites that is occupied by the drug (the occupancy of the site) can often be determined. To the extent that occupancy is a good indicator of pharmacological activity, such PET experiments can aid the development of drug dosage regimens. Some of the general issues involved in PET studies of drug occupancy are discussed. There have been many such studies involving antipsychotic drugs and dopamine D2 receptor radioligands. Since neuroleptics have been extensively reviewed elsewhere, only the major findings are discussed here. Other binding sites (and drug classes) in the dopamine system to which this methodology has been applied include: the dopamine transporter (stimulant drugs) and monoamine oxidase A and B (antidepressant drugs). Occupancy studies are also possible for many drug targets beyond the dopamine system. JF - Drug Development Research AU - Gatley, S John AU - Volkow, Nora D AU - Fowler, Joanna S AU - Ding, Yu-Shin AU - Logan, Jean AU - Wang, Gene-Jack AU - Gifford, Andrew N AD - Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York, gatley@bnl.gov Y1 - 2003/06// PY - 2003 DA - Jun 2003 SP - 194 EP - 207 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 59 IS - 2 SN - 0272-4391, 0272-4391 KW - Biotechnology Research Abstracts (through 1992); CSA Neurosciences Abstracts KW - Dopamine D2 receptors KW - Amine oxidase (flavin-containing) KW - Stimulants KW - Drug development KW - Antidepressants KW - Dopamine transporter KW - Reviews KW - Neuroleptics KW - Positron emission tomography KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20416914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Development+Research&rft.atitle=Positron+emission+tomography+and+its+use+to+image+the+occupancy+of+drug+binding+sites&rft.au=Gatley%2C+S+John%3BVolkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BDing%2C+Yu-Shin%3BLogan%2C+Jean%3BWang%2C+Gene-Jack%3BGifford%2C+Andrew+N&rft.aulast=Gatley&rft.aufirst=S&rft.date=2003-06-01&rft.volume=59&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Drug+Development+Research&rft.issn=02724391&rft_id=info:doi/10.1002%2Fddr.10219 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Positron emission tomography; Drug development; Dopamine D2 receptors; Neuroleptics; Stimulants; Antidepressants; Reviews; Dopamine transporter; Amine oxidase (flavin-containing) DO - http://dx.doi.org/10.1002/ddr.10219 ER - TY - JOUR T1 - The addicted human brain: insights from imaging studies. AN - 73282290; 12750391 JF - The Journal of clinical investigation AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene-Jack AD - Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 1444 EP - 1451 VL - 111 IS - 10 SN - 0021-9738, 0021-9738 KW - Street Drugs KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Nerve Net -- physiopathology KW - Magnetic Resonance Imaging KW - Animals KW - Reward KW - Motivation KW - Disease Susceptibility KW - Memory -- drug effects KW - Humans KW - Nerve Net -- drug effects KW - Tomography, Emission-Computed KW - Learning -- drug effects KW - Primates KW - Substance-Related Disorders -- physiopathology KW - Brain -- physiopathology KW - Substance-Related Disorders -- diagnosis KW - Street Drugs -- pharmacology KW - Brain -- drug effects KW - Street Drugs -- adverse effects KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73282290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=The+addicted+human+brain%3A+insights+from+imaging+studies.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2003-05-01&rft.volume=111&rft.issue=10&rft.spage=1444&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-06-04 N1 - Date created - 2003-05-16 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2787-8 [9096295] Behav Brain Res. 2002 Dec 2;137(1-2):75-114 [12445717] Science. 1997 Oct 3;278(5335):45-7 [9311924] Neuron. 1997 Sep;19(3):591-611 [9331351] Pharmacol Biochem Behav. 1998 Feb;59(2):287-93 [9476972] Am J Psychiatry. 1998 Aug;155(8):1009-15 [9699686] Am J Psychiatry. 1999 Jan;156(1):11-8 [9892292] Am J Psychiatry. 1999 Jan;156(1):19-26 [9892293] Life Sci. 1999;64(9):775-84 [10075110] Eur J Pharmacol. 1999 Jun 30;375(1-3):13-30 [10443561] Am J Psychiatry. 1999 Sep;156(9):1440-3 [10484959] J Pharmacol Exp Ther. 1999 Oct;291(1):409-15 [10490931] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12040-5 [8876259] Cereb Cortex. 2000 Mar;10(3):272-84 [10731222] Cereb Cortex. 2000 Mar;10(3):284-94 [10731223] Cereb Cortex. 2000 Mar;10(3):318-25 [10731226] Life Sci. 2000 Feb 11;66(12):PL161-7 [10737368] Addiction. 2000 Aug;95 Suppl 2:S119-28 [11002907] Prog Brain Res. 2000;126:217-29 [11105649] Neuropsychopharmacology. 2001 Feb;24(2):97-129 [11120394] Biol Psychiatry. 2001 Jan 15;49(2):81-96 [11164755] Synapse. 2001 Mar 1;39(3):257-66 [11169774] J Neurosci. 2001 Jan 15;21(2):RC121 [11160455] Brain Res Mol Brain Res. 2001 Feb 19;87(1):124-43 [11223167] Nat Rev Neurosci. 2001 Feb;2(2):119-28 [11252991] Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] Am J Psychiatry. 2001 Mar;158(3):390-8 [11229979] Annu Rev Neurosci. 2001;24:167-202 [11283309] Arch Gen Psychiatry. 2001 Apr;58(4):334-41 [11296093] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4728-33 [11274349] J Neurosci. 2001 Apr 15;21(8):2799-807 [11306632] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5300-5 [11320258] J Neurosci. 2001 Jun 1;21(11):4090-103 [11356897] Biol Psychiatry. 2001 Jun 1;49(11):894-905 [11377407] Exp Brain Res. 2001 Aug;139(3):278-86 [11545466] J Neurochem. 2001 Sep;78(5):1094-103 [11553683] Nat Rev Neurosci. 2001 Oct;2(10):695-703 [11584307] J Addict Dis. 2001;20(3):43-54 [11681592] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] Nat Neurosci. 2002 Feb;5(2):169-74 [11802171] Biol Psychiatry. 2002 Jan 15;51(2):134-42 [11822992] Neuropsychologia. 2002;40(10):1675-89 [11992656] J Neurosci. 2002 Jul 15;22(14):6247-53 [12122083] Nat Rev Drug Discov. 2002 Sep;1(9):710-26 [12209151] Synapse. 2002 Nov;46(2):79-82 [12211085] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] J Neurochem. 2002 Aug;82(4):721-35 [12358778] Neuron. 2002 Oct 10;36(2):229-40 [12383779] Synapse. 1993 Jun;14(2):169-77 [8101394] Psychopharmacology (Berl). 1994 Aug;115(4):441-6 [7871087] Arch Gen Psychiatry. 2002 Dec;59(12):1162-72 [12470133] Am J Psychiatry. 2003 Jan;160(1):33-40 [12505799] Science. 1988 Nov 4;242(4879):715-23 [2903550] Am J Psychiatry. 1991 May;148(5):621-6 [2018164] Synapse. 1992 Jul;11(3):184-90 [1636149] Arch Gen Psychiatry. 1992 Sep;49(9):739-44 [1514879] J Nucl Med. 1995 Jul;36(7):1182-90 [7790942] Nature. 1996 Feb 22;379(6567):733-6 [8602220] Addiction. 1996 Jul;91(7):921-49; discussion 951-65 [8688822] Behav Pharmacol. 2002 Sep;13(5-6):355-66 [12394411] J Neuropsychiatry Clin Neurosci. 2002 Fall;14(4):377-405 [12426407] Nature. 1997 Apr 24;386(6627):830-3 [9126741] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Murine EMT-6 carcinoma: high therapeutic efficacy of microbeam radiation therapy. AN - 73250728; 12710874 AB - Microbeam radiation therapy is an experimental modality using parallel arrays of thin (<100 micro m) slices of synchrotron-generated X rays (microplanar beams, microbeams). We used EMT-6 murine mammary carcinoma subcutaneously inoculated in the hind legs of mice to compare the therapeutic efficacies of single-fraction, unidirectional (1) "co-planar" microbeams (an array of vertically oriented microplanar beams), (2) "cross-planar" microbeams (two arrays of parallel microbeams propagated in the same direction, one with vertically and the other with horizontally oriented microplanar beams), and (3) seamless (broad) beams from the same synchrotron source. The microbeams were 90 micro m wide and were spaced 300 micro m on center; the median energy in all beams was 100 or 118 keV. Tumor ablation rates were 4/8, 4/8 and 6/7 for a 410-, 520- and 650-Gy in-slice cross-planar microbeam dose, respectively, and 1/8, 3/8, 3/7 and 6/8 for a 23-, 30-, 38- and 45-Gy broad-beam dose, respectively. When the data were pooled from the three highest doses (same average tumor ablations of 50-60%), the incidences of normal-tissue acute toxicity (moist desquamation and epilation) and delayed toxicity (failure of hair regrowth) were significantly lower for cross-planar microbeams than broad beams (P < 0.025). Furthermore, for the highest doses in these two groups, which also had the same tumor ablation rate (>75%), not only were the above toxicities lower for the cross-planar microbeams than for the broad beams (P < 0.02), but severe leg dysfunction was also lower (P < 0.003). These findings suggest that single-fraction microbeams can ablate tumors at high rates with relatively little normal-tissue toxicity. JF - Radiation research AU - Dilmanian, F Avraham AU - Morris, Gerard M AU - Zhong, Nan AU - Bacarian, Tigran AU - Hainfeld, James F AU - Kalef-Ezra, John AU - Brewington, Laura J AU - Tammam, Jennifer AU - Rosen, Eliot M AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Dilmanian@bnl.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 632 EP - 641 VL - 159 IS - 5 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Animals KW - Synchrotrons KW - Radiotherapy Dosage KW - Radiation Tolerance KW - Mice KW - Mice, Inbred BALB C KW - Female KW - X-Ray Therapy -- adverse effects KW - X-Ray Therapy -- methods KW - Mammary Neoplasms, Experimental -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73250728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Murine+EMT-6+carcinoma%3A+high+therapeutic+efficacy+of+microbeam+radiation+therapy.&rft.au=Dilmanian%2C+F+Avraham%3BMorris%2C+Gerard+M%3BZhong%2C+Nan%3BBacarian%2C+Tigran%3BHainfeld%2C+James+F%3BKalef-Ezra%2C+John%3BBrewington%2C+Laura+J%3BTammam%2C+Jennifer%3BRosen%2C+Eliot+M&rft.aulast=Dilmanian&rft.aufirst=F&rft.date=2003-05-01&rft.volume=159&rft.issue=5&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-29 N1 - Date created - 2003-04-24 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Positron emission tomography and single-photon emission computed tomography in substance abuse research. AN - 73284943; 12756644 AB - Many advances in the conceptualization of addiction as a disease of the brain have come from the application of imaging technologies directly in the human drug abuser. New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) and single-photon emission computed tomography (SPECT) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology, and medicine. This topic cuts across the medical specialties of neurology, psychiatry, oncology, and cardiology because of the high medical, social, and economic toll that drugs of abuse, including the legal drugs, cigarettes and alcohol, take on society. This article highlights recent advances in the use of PET and SPECT imaging to measure the pharmacokinetic and pharmacodynamic effects of drugs of abuse on the human brain. JF - Seminars in nuclear medicine AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene-Jack AD - Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 114 EP - 128 VL - 33 IS - 2 SN - 0001-2998, 0001-2998 KW - Street Drugs KW - 0 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Tomography, Emission-Computed, Single-Photon -- methods KW - Humans KW - Brain -- drug effects KW - Brain -- metabolism KW - Brain -- diagnostic imaging KW - Street Drugs -- pharmacology KW - Substance-Related Disorders -- etiology KW - Street Drugs -- adverse effects KW - Dopamine -- metabolism KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Street Drugs -- metabolism KW - Tomography, Emission-Computed -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73284943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+nuclear+medicine&rft.atitle=Positron+emission+tomography+and+single-photon+emission+computed+tomography+in+substance+abuse+research.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2003-04-01&rft.volume=33&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Seminars+in+nuclear+medicine&rft.issn=00012998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-10 N1 - Date created - 2003-05-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Rapid analytical technique to identify alpha emitting isotopes in water, air-filters, urine, and solid matrices using a Frisch Grid detector. AN - 73204371; 12705448 AB - A 5-inch-diameter Frisch Grid gas-proportional ionization chamber was utilized at Brookhaven National Laboratory (BNL) to rapidly characterize and quantify alpha-emitting actinides in unprocessed water, soil, air-filter, urine, and solid matrices. Instrument calibrations for the various matrices were performed by spiking representative samples with National Institute of Standards and Technology traceable isotopes of 230Th, 232U, 236Pu, and 243Am. Detection efficiencies were typically 15-20% for solid matrices (soil, concrete, filters, dry urine) and 45% for mass-less water samples. Instrument background over a 512-channel alpha-energy range of 3-8 MeV is very low at 0.01 cps. At optimum efficiency, minimum detectable levels of 0.56 mBq Kg(-1), 74 mBq L(-1) and 14.8 mBq filter(-1) were achievable for 40 x 10(-6) Kg soil, 1 x 10(-3) L tap water (or urine), and 4.5 cm diameter air-filter samples, respectively, each counted for 60 min. Data and spectra are presented showing the quality of results obtained using untreated samples obtained from the BNL Graphite Research Reactor Decommissioning Project. These samples contained Bq to MBq per gram amounts of (239,240)Pu, 241Am, and/or (234,235/238)U (as well as other beta/gamma emitters). Data and spectra are also presented for a very finely pulverized and homogeneous U.S. DOE/RESL soil reference standard (spiked with 239Pu, 241Am, and 233U) that was used to assess precision, accuracy, and reproducibility. Although this technique has its limitations, the advantages are (1) minimal sample preparation, (2) no separation chemistry required, (3) no chemical or hazardous waste generated, and (4) ability to immediately characterize and quantify alpha-emitting nuclides in most matrices. The benefits of this technique to the BNL/DOE Project Managers were rapid (1-2 d) turn-around times coupled with significant cost savings, as compared to commercial off-site analyses. JF - Health physics AU - Scarpitta, Salvatore C AU - Miltenberger, Robert P AU - Gaschott, Robert AU - Carte, Nina AD - Brookhaven National Laboratory, Upton, NY 11973, USA. scarpitta@bnl.gov Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 492 EP - 501 VL - 84 IS - 4 SN - 0017-9078, 0017-9078 KW - Air Pollutants, Radioactive KW - 0 KW - Dust KW - Radioactive Pollutants KW - Soil Pollutants, Radioactive KW - Water Pollutants, Radioactive KW - Index Medicus KW - Sensitivity and Specificity KW - Radiation Dosage KW - Transducers KW - Dust -- analysis KW - Reference Standards KW - Water Pollutants, Radioactive -- analysis KW - Calibration -- standards KW - Background Radiation KW - Equipment Design KW - Chemistry Techniques, Analytical -- methods KW - Equipment Failure Analysis KW - Air Pollutants, Radioactive -- analysis KW - Chemistry Techniques, Analytical -- instrumentation KW - Quality Control KW - Urine -- chemistry KW - Soil Pollutants, Radioactive -- analysis KW - Radiometry -- instrumentation KW - Radioactive Pollutants -- analysis KW - Alpha Particles KW - Radiometry -- methods KW - Radiation Monitoring UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73204371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Rapid+analytical+technique+to+identify+alpha+emitting+isotopes+in+water%2C+air-filters%2C+urine%2C+and+solid+matrices+using+a+Frisch+Grid+detector.&rft.au=Scarpitta%2C+Salvatore+C%3BMiltenberger%2C+Robert+P%3BGaschott%2C+Robert%3BCarte%2C+Nina&rft.aulast=Scarpitta&rft.aufirst=Salvatore&rft.date=2003-04-01&rft.volume=84&rft.issue=4&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-29 N1 - Date created - 2003-04-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Selegiline potentiates cocaine-induced increases in rodent nucleus accumbens dopamine. AN - 72985593; 12557270 AB - Selegiline has been proposed as a treatment for cocaine addiction and studies in humans suggest that it attenuates cocaine's reinforcing effects. Here we assessed the effects of selegiline treatment on cocaine-induced increases in nucleus accumbens (NAc) dopamine (DA) in freely moving rodents. Chronic treatment with selegiline (L-deprenyl, 0.25/mg/kg, 24 days) potentiated cocaine-induced increases in NAc DA from 350-600%. However, this enhanced response was abolished when animals were treated chronically with both cocaine and selegiline. Inasmuch as increases in NAc DA are associated with the reinforcing effects of cocaine, these results obtained in rodents suggest that MAO-A and -B inhibition may not be a suitable strategy to antagonize cocaine's reinforcing effects during cocaine detoxification. On the other hand, chronic selegiline treatment may improve DA deficits, which are thought to contribute to relapse through a decreased response to natural rewards. JF - Synapse (New York, N.Y.) AU - Schiffer, Wynne K AU - Azmoodeh, Manijeh AU - Gerasimov, Madina AU - Volkow, Nora D AU - Fowler, Joanna S AU - Dewey, Stephen L AD - Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA. wynne@bnl.gov Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 35 EP - 38 VL - 48 IS - 1 SN - 0887-4476, 0887-4476 KW - Dopamine Uptake Inhibitors KW - 0 KW - Neuroprotective Agents KW - Selegiline KW - 2K1V7GP655 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Microdialysis KW - Animals KW - Rats, Sprague-Dawley KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- metabolism KW - Drug Synergism KW - Time Factors KW - Male KW - Selegiline -- pharmacology KW - Dopamine -- metabolism KW - Dopamine -- analysis KW - Cocaine -- pharmacology KW - Neuroprotective Agents -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72985593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Selegiline+potentiates+cocaine-induced+increases+in+rodent+nucleus+accumbens+dopamine.&rft.au=Schiffer%2C+Wynne+K%3BAzmoodeh%2C+Manijeh%3BGerasimov%2C+Madina%3BVolkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2003-04-01&rft.volume=48&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-23 N1 - Date created - 2003-01-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - 3D GPR polarization analysis for imaging complex objects AN - 50871591; 2005-046627 JF - Proceedings of SAGEEP AU - Daniels, Jeffrey J AU - Wielopolski, Lucian AU - Radzevicius, Stan AU - Bookshar, Jess AU - Anonymous Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 585 EP - 597 PB - Environmental and Engineering Geophysical Society, Wheat Ridge, CO VL - 2003 KW - polarization KW - imagery KW - three-dimensional models KW - ground-penetrating radar KW - geophysical methods KW - radar methods KW - mathematical models KW - detection KW - identification KW - electromagnetic methods KW - applications KW - buried features KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50871591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+SAGEEP&rft.atitle=3D+GPR+polarization+analysis+for+imaging+complex+objects&rft.au=Daniels%2C+Jeffrey+J%3BWielopolski%2C+Lucian%3BRadzevicius%2C+Stan%3BBookshar%2C+Jess%3BAnonymous&rft.aulast=Daniels&rft.aufirst=Jeffrey&rft.date=2003-04-01&rft.volume=2003&rft.issue=&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+SAGEEP&rft.issn=1554-8015&rft_id=info:doi/ L2 - http://scitation.aip.org/sageep/ LA - English DB - GeoRef N1 - Conference title - Symposium on The application of geophysics to engineering and environmental problems N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 6 N1 - PubXState - CO N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - applications; buried features; detection; electromagnetic methods; geophysical methods; ground-penetrating radar; identification; imagery; mathematical models; polarization; radar methods; three-dimensional models ER - TY - JOUR T1 - Synthesis of Structurally Identical Fluorine-18 and Iodine Isotope Labeling Compounds for Comparative Imaging AN - 18748766; 5621472 AB - The synthesis of a benzophenone-based labeling compound designed for comparative imaging studies with both in vivo positron emission tomograph (PET) and single-photon computed tomography (SPECT) and ex vivo autoradiography is described. The new compound can be labeled with either F-18 or iodine radioisotopes to give two different radioisotopmers: N-[2-fluoro-5-(3-[I-131]iodobenzoyl)benzyl]-2-bromoacetamide (1) and N-[2-[F-18]fluoro-5-(3-iodobenzoyl)benzyl]-2-bromoacetamide (2). Compound 1 and 2 have a 2-bromoacetyl group, which can be used to conjugate with biomolecules through a nucleophilic substitution reaction. Compound 1 was synthesized from the corresponding tributyltin derivatives via an oxidative destannylation reaction, and compound 2 was prepared via a four-step radiosynthesis (nucleophilic aromatic substitution, reduction, oxidation, and alkylation) starting from 4-(N,N,N-trimethylammonio)-3-cyano-3'-iodobenzophenone triflate. A remarkably high radiochemical yield (>90%) was achieved for the F-18 nucleophilic aromatic substitution under mild conditions (room temperature in less than 10 min), indicating the structural advantage of the designed molecule to facilitate the F-18 for trimethylammonium substitution in the presence of two electron-withdrawing groups (nitrile and carbonyl). The overall radiosynthesis time for compound 2 is less than 3 h after end of bombardment (EOB) with an unoptimized radiochemical yield of about 2% (not decay corrected) and specific activity of 0.8 Ci/ mu mol at EOB. The radiolabeling precursors for compound 1 and 2 were synthesized via a carbon-carbon bond-forming reaction between 2-substituted-5-lithiobenzonitrile and 3-substituted benzaldehyde derivatives. Compounds 1 and 2 should allow us to label biomolecules with F-18 or iodine isotopes and gives structurally identical products, which are expected to have identical biological properties and should be useful for comparative imaging studies. JF - Bioconjugate Chemistry AU - Li, Z AU - Ding, Y-S AU - Gifford, A AU - Fowler, J S AU - Gatley, J S AD - Medical Department and Chemistry Department, Brookhaven National Laboratory, Upton, New York 11978, USA Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 287 EP - 294 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org], [URL:http://pubs.acs.org] VL - 14 IS - 2 SN - 1043-1802, 1043-1802 KW - benzophenone KW - comparative imaging KW - fluorine 18 KW - iodine KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18748766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Synthesis+of+Structurally+Identical+Fluorine-18+and+Iodine+Isotope+Labeling+Compounds+for+Comparative+Imaging&rft.au=Li%2C+Z%3BDing%2C+Y-S%3BGifford%2C+A%3BFowler%2C+J+S%3BGatley%2C+J+S&rft.aulast=Li&rft.aufirst=Z&rft.date=2003-03-01&rft.volume=14&rft.issue=2&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc025616nS1043-1802%2802%2905616-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1021/bc025616nS1043-1802(02)05616-1 ER - TY - JOUR T1 - A pseudo-force iterative method with separate scale factors for dynamic analysis of structures with non-proportional damping AN - 52020615; 2003-019549 AB - Dynamic equilibrium equations of structural systems with non-proportional damping are coupled through the damping terms. Such coupling invalidates application of the classical modal superposition method. In this paper, a mode-superposition pseudo-force method is proposed. The coupled equilibrium equations are solved by an iterative process in which the coupling terms are treated as pseudo-forces. A scale factor for each mode of the system is obtained by optimizing the iteration convergence. Through these uniquely solved scale factors, the modified modal equations not only converge much faster but also yield results with higher accuracy. A proof of the convergence of the iterative process is also presented. Abstract Copyright (2003), Wiley Periodicals, Inc. JF - Earthquake Engineering & Structural Dynamics AU - Lin, Feng-Bao AU - Wang, Yung-Kuo AU - Cho, Young S Y1 - 2003/02// PY - 2003 DA - February 2003 SP - 329 EP - 337 PB - Wiley & Sons, Chichester-New York VL - 32 IS - 2 SN - 0098-8847, 0098-8847 KW - scale factor KW - attenuation KW - Claret method KW - soil-structure interface KW - iterative methods KW - mathematical methods KW - equations KW - aseismic design KW - equilibrium KW - accuracy KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52020615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Earthquake+Engineering+%26+Structural+Dynamics&rft.atitle=A+pseudo-force+iterative+method+with+separate+scale+factors+for+dynamic+analysis+of+structures+with+non-proportional+damping&rft.au=Lin%2C+Feng-Bao%3BWang%2C+Yung-Kuo%3BCho%2C+Young+S&rft.aulast=Lin&rft.aufirst=Feng-Bao&rft.date=2003-02-01&rft.volume=32&rft.issue=2&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Earthquake+Engineering+%26+Structural+Dynamics&rft.issn=00988847&rft_id=info:doi/10.1002%2Feqe.234 L2 - http://www3.interscience.wiley.com/journal/1922/home LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2003-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - accuracy; aseismic design; attenuation; Claret method; equations; equilibrium; iterative methods; mathematical methods; scale factor; soil-structure interface DO - http://dx.doi.org/10.1002/eqe.234 ER - TY - BOOK T1 - Tropospheric aerosols AN - 884411718; 2011-067499 JF - The atmosphere AU - Buseck, P R AU - Schwartz, S E A2 - Keeling, R. F. A2 - Holland, H. D. A2 - Turekian, K. K. Y1 - 2003 PY - 2003 DA - 2003 PB - Elsevier, Oxford SN - 0080437516 KW - pollution KW - troposphere KW - climate change KW - bibliography KW - urban environment KW - air pollution KW - spatial variations KW - optical properties KW - transport KW - rural environment KW - aerosols KW - geochemistry KW - review KW - particles KW - climate KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/884411718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Buseck%2C+P+R%3BSchwartz%2C+S+E&rft.aulast=Buseck&rft.aufirst=P&rft.date=2003-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0080437516&rft.btitle=Tropospheric+aerosols&rft.title=Tropospheric+aerosols&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2011-01-01 N1 - Number of references - 203 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Recent advances in the development and commercialization of geothermal silica products AN - 881457494; 2011-065435 AB - Systematic studies of the chemical and physical properties of geothermal silicas have shown that these properties vary to a significant extent and depend on their original source and its relative composition. However, under certain processing conditions, geothermal brines can cost-efficiently, yield a number of commercially attractive silica products. Co-production of such products can lower the cost of the overall geothermal energy production and simultaneously expands and enriches the usability of the geothermal resources. In this paper the production, economics and application of high quality silica from geothermal brines will be discussed in terms of several specific examples. JF - Transactions - Geothermal Resources Council AU - Lin, Mow S AU - Premuzic, Eugene T AU - Dong, Bin AU - Zhou, Wei M AU - Johnson, Stuart D AU - Gutierrez-Puente, Hector AU - Garg, Sabodh K Y1 - 2003 PY - 2003 DA - 2003 SP - 547 EP - 550 PB - GRC - Geothermal Resources Council, Davis, CA VL - 27 SN - 0193-5933, 0193-5933 KW - chromatography KW - markets KW - properties KW - salinity KW - byproducts KW - silicon KW - production KW - recovery KW - molecular structure KW - geothermal energy KW - geothermal fields KW - reagents KW - thin layer chromatography KW - silica KW - brines KW - nonmetal deposits KW - pilot plants KW - testing KW - economics KW - transformations KW - chemical composition KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881457494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+-+Geothermal+Resources+Council&rft.atitle=Recent+advances+in+the+development+and+commercialization+of+geothermal+silica+products&rft.au=Lin%2C+Mow+S%3BPremuzic%2C+Eugene+T%3BDong%2C+Bin%3BZhou%2C+Wei+M%3BJohnson%2C+Stuart+D%3BGutierrez-Puente%2C+Hector%3BGarg%2C+Sabodh+K&rft.aulast=Lin&rft.aufirst=Mow&rft.date=2003-01-01&rft.volume=27&rft.issue=&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Transactions+-+Geothermal+Resources+Council&rft.issn=01935933&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geothermal resources council, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2011-01-01 N1 - Number of references - 10 N1 - PubXState - CA N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - brines; byproducts; chemical composition; chromatography; economics; geothermal energy; geothermal fields; markets; molecular structure; nonmetal deposits; pilot plants; production; properties; reagents; recovery; salinity; silica; silicon; testing; thin layer chromatography; transformations ER - TY - JOUR T1 - Monoamine oxidase and cigarette smoking. AN - 72999190; 12564384 AB - Current cigarette smokers have reduced monoamine oxidase (MAO) and there is evidence that this is a pharmacological effect of tobacco smoke exposure rather than a biological characteristic of smokers. This article summarizes human and animal studies documenting the inhibitory effects of tobacco smoke on MAO and discusses MAO inhibition in the context of smoking epidemiology, MAO inhibitor compounds in tobacco, reinvestigations of low platelet MAO in psychiatric disorders and smoking cessation. JF - Neurotoxicology AU - Fowler, Joanna S AU - Logan, Jean AU - Wang, Gene-Jack AU - Volkow, Nora D AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. fowler@bnl.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 75 EP - 82 VL - 24 IS - 1 SN - 0161-813X, 0161-813X KW - Monoamine Oxidase Inhibitors KW - 0 KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Index Medicus KW - Brain -- enzymology KW - Animals KW - Smoking Cessation -- psychology KW - Monoamine Oxidase Inhibitors -- metabolism KW - Humans KW - Mental Disorders -- enzymology KW - Mental Disorders -- psychology KW - Smoking -- metabolism KW - Smoking -- psychology KW - Monoamine Oxidase -- metabolism KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72999190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Monoamine+oxidase+and+cigarette+smoking.&rft.au=Fowler%2C+Joanna+S%3BLogan%2C+Jean%3BWang%2C+Gene-Jack%3BVolkow%2C+Nora+D&rft.aulast=Fowler&rft.aufirst=Joanna&rft.date=2003-01-01&rft.volume=24&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-21 N1 - Date created - 2003-02-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Synchrotron X-ray diffraction study of the structure and dehydration behavior of todorokite AN - 52013415; 2003-024310 AB - Real-time, temperature-resolved synchrotron powder X-ray diffraction data and Rietveld refinements were used to investigate the behavior of the todorokite structure from 100 to 820 K. At 298 K, the lower valence cations, such as Mn (super 3+) , occupy large octahedral sites at the edges of the triple chains, and four water/cation sites are in the tunnels. In our heating experiments in vacuum, todorokite began to break down at approximately 450 K and fully decomposed by 620 K, at which point hausmannite started to form. Our results suggest that the loss of O (sub 2) accompanied the reduction of Mn (super 4+) to Mn (super 3+) and Mn (super 2+) , and these reactions impelled a breakdown of the octahedral framework and the subsequent release of the tunnel water molecules. Rietveld refinements revealed a gradual thermal expansion of todorokite structure to approximately 450 K. At higher temperatures, the unit-cell volume gradually decreased, primarily as a result of a decrease in c, and the decline in beta with increasing temperature was accelerated. A mechanism for forming the inverse spinel hausmannite structure from todorokite is presented. JF - American Mineralogist AU - Post, Jeffrey E AU - Heaney, Peter J AU - Hanson, Jonathan Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 142 EP - 150 PB - Mineralogical Society of America, Washington, DC VL - 88 IS - 1 SN - 0003-004X, 0003-004X KW - experimental studies KW - X-ray diffraction data KW - unit cell KW - phase transitions KW - crystal structure KW - bonding KW - Rietveld refinement KW - temperature KW - todorokite KW - hausmannite KW - oxides KW - heating KW - synchrotrons KW - dehydration KW - high temperature KW - P-T conditions KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52013415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Synchrotron+X-ray+diffraction+study+of+the+structure+and+dehydration+behavior+of+todorokite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+Peter+J%3BHanson%2C+Jonathan&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2003-01-01&rft.volume=88&rft.issue=1&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 33 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - bonding; crystal structure; dehydration; experimental studies; hausmannite; heating; high temperature; oxides; P-T conditions; phase transitions; Rietveld refinement; synchrotrons; temperature; todorokite; unit cell; X-ray diffraction data ER - TY - JOUR T1 - Study of the microgeometry of porous materials using synchrotron computed microtomography AN - 51899625; 2004-011033 AB - A series of measurements of the structure of a variety of porous materials has been made using synchrotron computed microtomography (SCMT). The work was carried out at the Brookhaven National Synchrotron Light Source (NSLS), the Argonne Advanced Photon Source (APS) and the European Synchrotron Radiation Facility (ESRF). The experiments at Brookhaven and Argonne were carried out on bending magnet beam lines using area detectors to obtain CT images based on determination of X-ray absorption coefficients. The work at the ESRF used an undulator beam line, a 13 KeV pencil X-ray beam of 2 mu m and an energy dispersive X-ray detector to make tomographic sections of trace element distributions by X-ray fluorescence tomography. Most of the work was done with a pixel/voxel size ranging from 0.002 to 0.010 mm. We examined the structure of unconsolidated estuarine sediments, whose structure is relevant to transport of contaminants in rivers and estuaries. Fluorescent tomography with 2-3 mu m resolution was used to ascertain whether or not metals were concentrated on the surface or throughout the volume of a single sediment particle. Sandstone samples were investigated to obtain a set of values describing their microstructures that could be useful in fluid flow calculations relevant to petroleum recovery or transport of environmental contaminants. Measurements were also made on sandstone samples that had been subjected to high-pressure compression to investigate the relation between the microgeometry and the magnitude of the applied pressure. Finally, a Wood's metal-filled sample was scanned for demonstration of resolution enhancement and fluid flow studies. JF - Geological Society Special Publications AU - Jones, K W AU - Feng, H AU - Lindquist, W B AU - Adler, P M AU - Thovert, J F AU - Vekemans, B AU - Vincze, L AU - Szaloki, I AU - van Grieken, R AU - Adams, F AU - Riekel, C A2 - Mees, F. A2 - Swennen, R. A2 - van Geet, M. A2 - Jacobs, P. Y1 - 2003 PY - 2003 DA - 2003 SP - 39 EP - 49 PB - Geological Society of London, London VL - 215 SN - 0305-8719, 0305-8719 KW - United States KW - solute transport KW - New Jersey Harbor KW - chlorinated hydrocarbons KW - imagery KW - strain KW - PCBs KW - Europe KW - fluid dynamics KW - reservoir rocks KW - synchrotron radiation KW - France KW - visualization KW - laboratory studies KW - marine sediments KW - sedimentary rocks KW - sediments KW - X-ray analysis KW - halogenated hydrocarbons KW - applications KW - high-resolution methods KW - experimental studies KW - Western Europe KW - three-dimensional models KW - textures KW - pollutants KW - grain size KW - pollution KW - porous materials KW - porosity KW - geometry KW - compaction KW - case studies KW - Vosges France KW - organic compounds KW - metals KW - New Jersey KW - North Sea KW - North Atlantic KW - computed tomography data KW - Vosges Sandstone KW - instruments KW - Atlantic Ocean KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51899625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geological+Society+Special+Publications&rft.atitle=Study+of+the+microgeometry+of+porous+materials+using+synchrotron+computed+microtomography&rft.au=Jones%2C+K+W%3BFeng%2C+H%3BLindquist%2C+W+B%3BAdler%2C+P+M%3BThovert%2C+J+F%3BVekemans%2C+B%3BVincze%2C+L%3BSzaloki%2C+I%3Bvan+Grieken%2C+R%3BAdams%2C+F%3BRiekel%2C+C&rft.aulast=Jones&rft.aufirst=K&rft.date=2003-01-01&rft.volume=215&rft.issue=&rft.spage=39&rft.isbn=1862391394&rft.btitle=&rft.title=Geological+Society+Special+Publications&rft.issn=03058719&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 23 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - GSLSBW N1 - SubjectsTermNotLitGenreText - applications; Atlantic Ocean; case studies; chlorinated hydrocarbons; compaction; computed tomography data; Europe; experimental studies; fluid dynamics; France; geometry; grain size; halogenated hydrocarbons; high-resolution methods; imagery; instruments; laboratory studies; marine sediments; metals; New Jersey; New Jersey Harbor; North Atlantic; North Sea; organic compounds; PCBs; pollutants; pollution; porosity; porous materials; reservoir rocks; sedimentary rocks; sediments; solute transport; strain; synchrotron radiation; textures; three-dimensional models; United States; visualization; Vosges France; Vosges Sandstone; Western Europe; X-ray analysis ER - TY - JOUR T1 - The use of alternative techniques for remediation of polluted sites and groundwater in Flanders; plant-based strategies AN - 51837518; 2004-045727 JF - Journal of Soils and Sediments AU - Vangronsveld, Jaco AU - van der Lelie, Daniel Y1 - 2003 PY - 2003 DA - 2003 SP - 250 EP - 251 PB - Ecomed Publishers, Landsberg VL - 3 IS - 4 SN - 1439-0108, 1439-0108 KW - soils KW - water quality KW - Western Europe KW - pollutants KW - pollution KW - Europe KW - bioremediation KW - Flanders Belgium KW - remediation KW - ground water KW - aquifers KW - Belgium KW - phytoremediation KW - discharge KW - smelting KW - heavy metals KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51837518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Soils+and+Sediments&rft.atitle=The+use+of+alternative+techniques+for+remediation+of+polluted+sites+and+groundwater+in+Flanders%3B+plant-based+strategies&rft.au=Vangronsveld%2C+Jaco%3Bvan+der+Lelie%2C+Daniel&rft.aulast=Vangronsveld&rft.aufirst=Jaco&rft.date=2003-01-01&rft.volume=3&rft.issue=4&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Journal+of+Soils+and+Sediments&rft.issn=14390108&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 4 N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aquifers; Belgium; bioremediation; discharge; Europe; Flanders Belgium; ground water; heavy metals; microorganisms; phytoremediation; pollutants; pollution; remediation; smelting; soils; water quality; Western Europe ER - TY - JOUR T1 - Arsenic XAFS spectroscopy as a monitor for controlled pyrite oxidation in selected bituminous coal samples AN - 51580746; 2006-046404 JF - Programme & Abstracts - International Symposium on Environmental Geochemistry (ISEG) AU - Kolker, A AU - Huggins, F AU - Khalid, S AU - Farmer, John G Y1 - 2003 PY - 2003 DA - 2003 SP - 86 PB - [varies], [varies] VL - 6 KW - qualitative analysis KW - bituminous coal KW - sedimentary rocks KW - coal KW - X-ray analysis KW - applications KW - toxic materials KW - experimental studies KW - chemical analysis KW - monitoring KW - acid mine drainage KW - pollutants KW - oxidation KW - arsenic KW - pollution KW - weathering KW - sample preparation KW - metals KW - XANES KW - X-ray spectroscopy KW - pyrite KW - XAFS KW - sulfides KW - spectroscopy KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51580746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Programme+%26+Abstracts+-+International+Symposium+on+Environmental+Geochemistry+%28ISEG%29&rft.atitle=Arsenic+XAFS+spectroscopy+as+a+monitor+for+controlled+pyrite+oxidation+in+selected+bituminous+coal+samples&rft.au=Kolker%2C+A%3BHuggins%2C+F%3BKhalid%2C+S%3BFarmer%2C+John+G&rft.aulast=Kolker&rft.aufirst=A&rft.date=2003-01-01&rft.volume=6&rft.issue=&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Programme+%26+Abstracts+-+International+Symposium+on+Environmental+Geochemistry+%28ISEG%29&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 6th international symposium on Environmental geochemistry N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 1 N1 - Last updated - 2012-06-07 N1 - CODEN - #06649 N1 - SubjectsTermNotLitGenreText - acid mine drainage; applications; arsenic; bituminous coal; chemical analysis; coal; experimental studies; metals; monitoring; oxidation; pollutants; pollution; pyrite; qualitative analysis; sample preparation; sedimentary rocks; spectroscopy; sulfides; toxic materials; weathering; X-ray analysis; X-ray spectroscopy; XAFS; XANES ER - TY - JOUR T1 - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space AN - 51481651; 2007-022861 JF - Advances in Space Research A2 - Horneck, G. A2 - Vasquez, M. E. A2 - Porterfield, D. M. Y1 - 2003 PY - 2003 DA - 2003 SP - 272 PB - Elsevier, Oxford-New York VL - 31 IS - 1 SN - 0273-1177, 0273-1177 KW - terrestrial planets KW - planets KW - Plantae KW - symposia KW - planetology KW - astrobiology KW - Mars KW - research KW - life support systems KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51481651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Advances+in+Space+Research&rft.atitle=Thirty-third+COSPAR+scientific+assembly+on+Space+life+sciences%3B+missions+to+Mars%2C+radiation+biology%2C+and+plants+as+a+foundation+for+long-term+life+support+systems+in+space&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2003-01-01&rft.volume=31&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Advances+in+Space+Research&rft.issn=02731177&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/02731177 LA - English DB - GeoRef N1 - Conference title - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Document feature - illus. incl. tables N1 - SuppNotes - Individual papers within scope are cited separately N1 - Last updated - 2012-06-07 N1 - CODEN - ASRSDW N1 - SubjectsTermNotLitGenreText - astrobiology; life support systems; Mars; planetology; planets; Plantae; research; symposia; terrestrial planets ER - TY - JOUR T1 - Sterilisation properties of the Mars surface and atmospheric environment AN - 51481281; 2007-022862 JF - Advances in Space Research AU - Moreau, Didier AU - Muller, Christian Y1 - 2003 PY - 2003 DA - 2003 SP - 97 EP - 102 PB - Elsevier, Oxford-New York VL - 31 IS - 1 SN - 0273-1177, 0273-1177 KW - terrestrial planets KW - models KW - surface properties KW - sterilization KW - planets KW - photochemistry KW - atmosphere KW - Mars KW - properties KW - geochemistry KW - exploration KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51481281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Space+Research&rft.atitle=Sterilisation+properties+of+the+Mars+surface+and+atmospheric+environment&rft.au=Moreau%2C+Didier%3BMuller%2C+Christian&rft.aulast=Moreau&rft.aufirst=Didier&rft.date=2003-01-01&rft.volume=31&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Advances+in+Space+Research&rft.issn=02731177&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/02731177 LA - English DB - GeoRef N1 - Conference title - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 6 N1 - Document feature - illus. N1 - Last updated - 2014-09-18 N1 - CODEN - ASRSDW N1 - SubjectsTermNotLitGenreText - atmosphere; exploration; geochemistry; Mars; models; photochemistry; planets; properties; sterilization; surface properties; terrestrial planets ER - TY - JOUR T1 - Biochemical treatment of produced water AN - 51437590; 2007-053968 JF - Abstracts - AAPG Mid-Continent Section Meeting AU - Lin, Mow AU - Anonymous Y1 - 2003 PY - 2003 DA - 2003 EP - unpaginated PB - American Association of Petroleum Geologists, Mid-Continent Section, Tulsa, OK VL - 2003 KW - water KW - oil wells KW - biodegradation KW - fluid injection KW - pollutants KW - water treatment KW - purification KW - pollution KW - crude oil KW - water pollution KW - heavy metals KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51437590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+-+AAPG+Mid-Continent+Section+Meeting&rft.atitle=Biochemical+treatment+of+produced+water&rft.au=Lin%2C+Mow%3BAnonymous&rft.aulast=Lin&rft.aufirst=Mow&rft.date=2003-01-01&rft.volume=2003&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstracts+-+AAPG+Mid-Continent+Section+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.searchanddiscovery.net/abstracts/pdf/2003/midcon/abs/ndx_lin.pdf LA - English DB - GeoRef N1 - Conference title - AAPG Mid-Continent Section meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - PubXState - OK N1 - SuppNotes - Accessed on Aug. 25, 2006 N1 - Last updated - 2012-06-07 N1 - CODEN - #06711 N1 - SubjectsTermNotLitGenreText - biodegradation; crude oil; fluid injection; heavy metals; oil wells; pollutants; pollution; purification; water; water pollution; water treatment ER - TY - JOUR T1 - Synchrotron-based mu XRD and mu XANES on arsenic-bearing mine waste from Yellowknife AN - 51436822; 2007-053719 JF - Program with Abstracts - Geological Association of Canada; Mineralogical Association of Canada: Joint Annual Meeting AU - Walker, S R AU - Andrade, C F AU - Jamieson, H E AU - Lanzirotti, A AU - Anonymous Y1 - 2003 PY - 2003 DA - 2003 EP - unpaginated PB - Geological Association of Canada, Waterloo, ON VL - 28 SN - 0701-8738, 0701-8738 KW - mines KW - experimental studies KW - chemical analysis KW - mine waste KW - X-ray diffraction data KW - waste rock KW - pollutants KW - arsenic KW - pollution KW - X-ray spectra KW - Northwest Territories KW - XANES spectra KW - synchrotron radiation KW - laboratory studies KW - Canada KW - Yellowknife Northwest Territories KW - metals KW - Western Canada KW - spectra KW - geochemistry KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51436822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Program+with+Abstracts+-+Geological+Association+of+Canada%3B+Mineralogical+Association+of+Canada%3A+Joint+Annual+Meeting&rft.atitle=Synchrotron-based+mu+XRD+and+mu+XANES+on+arsenic-bearing+mine+waste+from+Yellowknife&rft.au=Walker%2C+S+R%3BAndrade%2C+C+F%3BJamieson%2C+H+E%3BLanzirotti%2C+A%3BAnonymous&rft.aulast=Walker&rft.aufirst=S&rft.date=2003-01-01&rft.volume=28&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Program+with+Abstracts+-+Geological+Association+of+Canada%3B+Mineralogical+Association+of+Canada%3A+Joint+Annual+Meeting&rft.issn=07018738&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Association of Canada, Mineralogical Association of Canada; joint annual meeting--Association geologique du Canada, Association mineralogique du Canada; congres annuel conjoint N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - PubXState - ON N1 - SuppNotes - All meeting abstracts available at http://gac.esd.mun.ca/gac_2003/search_abs/program.htm N1 - Last updated - 2012-06-07 N1 - CODEN - PAACD6 N1 - SubjectsTermNotLitGenreText - arsenic; Canada; chemical analysis; experimental studies; geochemistry; laboratory studies; metals; mine waste; mines; Northwest Territories; pollutants; pollution; spectra; synchrotron radiation; waste rock; Western Canada; X-ray diffraction data; X-ray spectra; XANES spectra; Yellowknife Northwest Territories ER - TY - JOUR T1 - Comments from the point of view of chemical evolution and origins of life AN - 50252685; 2007-022864 JF - Advances in Space Research AU - Kobayashi, K Y1 - 2003 PY - 2003 DA - 2003 SP - 109 PB - Elsevier, Oxford-New York VL - 31 IS - 1 SN - 0273-1177, 0273-1177 KW - terrestrial planets KW - planets KW - organic compounds KW - Earth KW - biochemistry KW - planetology KW - Mars KW - concepts KW - life origin KW - exploration KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50252685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Space+Research&rft.atitle=Comments+from+the+point+of+view+of+chemical+evolution+and+origins+of+life&rft.au=Kobayashi%2C+K&rft.aulast=Kobayashi&rft.aufirst=K&rft.date=2003-01-01&rft.volume=31&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Advances+in+Space+Research&rft.issn=02731177&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/02731177 LA - English DB - GeoRef N1 - Conference title - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 2 N1 - Last updated - 2014-09-18 N1 - CODEN - ASRSDW N1 - SubjectsTermNotLitGenreText - biochemistry; concepts; Earth; exploration; life origin; Mars; organic compounds; planetology; planets; terrestrial planets ER - TY - JOUR T1 - Planetary protection and the search for life beneath the surface of Mars AN - 50248891; 2007-022863 JF - Advances in Space Research AU - Mancinelli, Rocco L Y1 - 2003 PY - 2003 DA - 2003 SP - 103 EP - 107 PB - Elsevier, Oxford-New York VL - 31 IS - 1 SN - 0273-1177, 0273-1177 KW - water KW - terrestrial planets KW - protection KW - surface properties KW - planets KW - sampling KW - planetology KW - Mars KW - life origin KW - exploration KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50248891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Space+Research&rft.atitle=Planetary+protection+and+the+search+for+life+beneath+the+surface+of+Mars&rft.au=Mancinelli%2C+Rocco+L&rft.aulast=Mancinelli&rft.aufirst=Rocco&rft.date=2003-01-01&rft.volume=31&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Advances+in+Space+Research&rft.issn=02731177&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/02731177 LA - English DB - GeoRef N1 - Conference title - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 13 N1 - Last updated - 2014-09-18 N1 - CODEN - ASRSDW N1 - SubjectsTermNotLitGenreText - exploration; life origin; Mars; planetology; planets; protection; sampling; surface properties; terrestrial planets; water ER - TY - JOUR T1 - The Application of Molecular Tools to Follow up Bioremediation AN - 19428772; 5915862 AB - During the last decades, major advances have been made in understanding the mechanisms of interactions between microorganisms and pollutants, and in the application of specialized microorganisms for the in situ and ex situ treatment of organic xenobiotics, heavy metal and radionuclide contaminated soils, wastes and groundwater. The efficiency of bioremediation depends on the presence and activities of the microorganisms involved which is, in turn, affected by environmental conditions, operational parameters and the local composition of the overall microbial community composition. Hence, when opting for a biological remediation strategy, important questions to be answered as part of the overall remediation strategy include: (i) are microorganisms with the desired characteristics and activities present at the contaminated site and at what densities, (ii) what is their activity, (iii) and how is the microbial community composition and functioning influenced by environmental parameters and process conditions? Recently, molecular and non-molecular methods for the identification and characterization of bacteria and their specific properties have been used to assess the composition and activity of microbial communities found at contaminated sites or in the rhizosphere of plants. For the future, these techniques contain the promise to be applied as complementary tools to classical chemical and physiological analytical methods (pollutant concentrations and speciation, redox potential, etc.) to monitor the spatial and temporary changes in microbial community composition and functioning during bioremediation processes. JF - Journal of Soils and Sediments AU - Geets, J AU - Vangronsveld, J AU - Diels, L AU - van der Lelie, D AD - Brookhaven National Laboratory, Biology Department, Building 463, Upton, NY11973-5000, USA, vdlelied@bnl.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 251 VL - 3 IS - 4 SN - 1439-0108, 1439-0108 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Pollution Abstracts KW - Bioremediation KW - Heavy metals KW - Rhizosphere KW - Wastes KW - Xenobiotics KW - Sediments KW - Soil microorganisms KW - Soil pollution KW - Community composition KW - Pollutants KW - Plant communities KW - Microorganisms KW - Ground water KW - Radioisotopes KW - Environmental conditions KW - Redox potential KW - A 01340:Antibiotics & Antimicrobials KW - W 30950:Waste Treatment & Pollution Clean-up KW - P 5000:LAND POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19428772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Soils+and+Sediments&rft.atitle=The+Application+of+Molecular+Tools+to+Follow+up+Bioremediation&rft.au=Geets%2C+J%3BVangronsveld%2C+J%3BDiels%2C+L%3Bvan+der+Lelie%2C+D&rft.aulast=Geets&rft.aufirst=J&rft.date=2003-01-01&rft.volume=3&rft.issue=4&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Journal+of+Soils+and+Sediments&rft.issn=14390108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2004-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Bioremediation; Heavy metals; Rhizosphere; Wastes; Xenobiotics; Sediments; Soil pollution; Community composition; Pollutants; Radioisotopes; Ground water; Microorganisms; Plant communities; Environmental conditions; Redox potential; Soil microorganisms ER - TY - JOUR T1 - Variation of the relaxographic "shutter-speed" for transcytolemmal water exchange affects the CR bolus-tracking curve shape AN - 19219899; 5764632 AB - Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR "shutter-speed" (T super(-1)) for the equilibrium transcytolemmal water exchange process increases. The quantity T super(-1) is given by |r sub(1o)[CR sub(o)] + R sub(1o0)-R sub(1i)| (where r sub(1o) and [CR sub(o)] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R sub(1o0) and R sub(1i) are the extra- and intracellular super(1)H sub(2)O relaxation rate constants, respectively, in the absence of exchange). The increase of T super(-1) with [CR sub(o)] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO super()). The shutter-speed effect alters the shape of the bolus-tracking (B-T) time- course. It is shown that this is mostly accounted for by the inclusion of only one additional parameter, which measures the mean intracellular lifetime of a water molecule. Simulated and real data demonstrate that the effect of shutter- speed variation on pharmacokinetic parameters can be very significant: neglecting this effect can lead to an underestimation of the parameter values by 50%. This phenomenon can be heterogeneous. Within a tiny gliosarcoma implanted in the rat brain, the interstitial CR in the tumor core never rises to a level sufficient to cause apparent slowing of the exchange process. However, within the few microns needed to reach the proliferating rim, this occurs to a significant degree. Thus, even relative pharmacokinetic quantities can be incorrectly represented in a parametric map that neglects this effect. The BOLERO analysis shows promise for in vivo vascular phenotyping in pathophysiology. It also includes a provision for approximating the separation of the perfusion and permeability contributions to CR extravasation. JF - Magnetic Resonance in Medicine AU - Yankeelov, TE AU - Rooney, W D AU - Li, X AU - Springer, CS Jr AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York, springer@ohsu.edu Y1 - 2003 PY - 2003 DA - 2003 SP - 1151 EP - 1169 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 50 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Water exchange KW - Pathophysiology KW - Relaxation KW - Magnetic resonance imaging KW - N.M.R. KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19219899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Variation+of+the+relaxographic+%22shutter-speed%22+for+transcytolemmal+water+exchange+affects+the+CR+bolus-tracking+curve+shape&rft.au=Yankeelov%2C+TE%3BRooney%2C+W+D%3BLi%2C+X%3BSpringer%2C+CS+Jr&rft.aulast=Yankeelov&rft.aufirst=TE&rft.date=2003-01-01&rft.volume=50&rft.issue=6&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.10624 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - N.M.R.; Magnetic resonance imaging; Water exchange; Relaxation; Pathophysiology DO - http://dx.doi.org/10.1002/mrm.10624 ER - TY - JOUR T1 - Echo planar imaging at 4 tesla with minimum acoustic noise AN - 18939802; 5685118 AB - To minimize the acoustic sound pressure levels of single-shot echo planar imaging (EPI) acquisitions on high magnetic field MRI scanners. The resonance frequencies of gradient coil vibrations, which depend on the coil length and the elastic properties of the materials in the coil assembly, were measured using piezoelectric transducers. The frequency of the EPI-readout train was adjusted to avoid the frequency ranges of mechanical resonances. Our MRI system exhibited two sharp mechanical resonances (at 720 and 1220 Hz) that can increase vibrational amplitudes up to six-fold. A small adjustment of the EPI-readout frequency made it possible to reduce the sound pressure level of EPI-based perfusion and functional MRI scans by 12 dB. Normal vibrational modes of MRI gradient coils can dramatically increase the sound pressure levels during echo planar imaging (EPI) scans. To minimize acoustic noise, the frequency of EPI- readout trains and the resonance frequencies of gradient coil vibrations need to be different. JF - Journal of Magnetic Resonance Imaging AU - Tomasi, D G AU - Ernst, T AD - Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Ave. Upton, NY, 11973, Tomasi@bnl.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 128 EP - 130 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 18 IS - 1 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Vibrations KW - Piezoelectricity KW - Acoustics KW - Magnetic resonance imaging KW - Noise KW - Mechanical properties KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18939802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Echo+planar+imaging+at+4+tesla+with+minimum+acoustic+noise&rft.au=Tomasi%2C+D+G%3BErnst%2C+T&rft.aulast=Tomasi&rft.aufirst=D&rft.date=2003-01-01&rft.volume=18&rft.issue=1&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.10326 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Noise; Acoustics; Mechanical properties; Piezoelectricity; Vibrations DO - http://dx.doi.org/10.1002/jmri.10326 ER - TY - JOUR T1 - Microanalysis of NY/NJ Harbor sediments using synchrotron X-ray beams AN - 1429845274; 2013-069649 JF - Proceedings - International Conference on Remediation of Contaminated Sediments AU - Jones, K W AU - Feng, H AU - Lanzirotti, A AU - Marinkovic, N AU - Neuhaeusler, U AU - Riekel, C AU - Vincze, L AU - Vekemans, B AU - Szaloki, I AU - Song, Z Y1 - 2003 PY - 2003 DA - 2003 EP - unpaginated PB - [varies], [varies] VL - 2 KW - United States KW - pollutants KW - harbors KW - pollution KW - techniques KW - New York/New Jersey Harbor KW - infrared spectra KW - synchrotron radiation KW - FTIR spectra KW - New York KW - detection KW - transport KW - sediments KW - ecology KW - spectra KW - particulate materials KW - New Jersey KW - depositional environment KW - estuarine environment KW - chemical composition KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1429845274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Remediation+of+Contaminated+Sediments&rft.atitle=Microanalysis+of+NY%2FNJ+Harbor+sediments+using+synchrotron+X-ray+beams&rft.au=Jones%2C+K+W%3BFeng%2C+H%3BLanzirotti%2C+A%3BMarinkovic%2C+N%3BNeuhaeusler%2C+U%3BRiekel%2C+C%3BVincze%2C+L%3BVekemans%2C+B%3BSzaloki%2C+I%3BSong%2C+Z&rft.aulast=Jones&rft.aufirst=K&rft.date=2003-01-01&rft.volume=2&rft.issue=&rft.spage=&rft.isbn=1574771434&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Remediation+of+Contaminated+Sediments&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Second international conference on Remediation of contaminated sediments N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2013-01-01 N1 - Number of references - 4 N1 - Document feature - illus. N1 - Last updated - 2013-09-05 N1 - CODEN - #06496 N1 - SubjectsTermNotLitGenreText - chemical composition; depositional environment; detection; ecology; estuarine environment; FTIR spectra; harbors; infrared spectra; New Jersey; New York; New York/New Jersey Harbor; particulate materials; pollutants; pollution; sediments; spectra; synchrotron radiation; techniques; transport; United States ER - TY - JOUR T1 - Natural attenuation for ecosystem restoration in the NY/NJ Harbor AN - 1429844655; 2013-069676 JF - Proceedings - International Conference on Remediation of Contaminated Sediments AU - van der Lelie, D AU - Jones, K W AU - Reid-Green, J D AU - Stern, E A Y1 - 2003 PY - 2003 DA - 2003 EP - unpaginated PB - [varies], [varies] VL - 2 KW - United States KW - reclamation KW - ecosystems KW - bioavailability KW - Passaic River KW - toxicity KW - sediments KW - natural attenuation KW - Gowanus Canal KW - heavy metals KW - soils KW - toxic materials KW - Newtown Creek KW - Newark Bay KW - harbors KW - pollution KW - New York/New Jersey Harbor KW - measurement KW - New York KW - detection KW - bacteria KW - New Jersey KW - Hudson River KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1429844655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Remediation+of+Contaminated+Sediments&rft.atitle=Natural+attenuation+for+ecosystem+restoration+in+the+NY%2FNJ+Harbor&rft.au=van+der+Lelie%2C+D%3BJones%2C+K+W%3BReid-Green%2C+J+D%3BStern%2C+E+A&rft.aulast=van+der+Lelie&rft.aufirst=D&rft.date=2003-01-01&rft.volume=2&rft.issue=&rft.spage=&rft.isbn=1574771434&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Remediation+of+Contaminated+Sediments&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Second international conference on Remediation of contaminated sediments N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2013-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2013-09-05 N1 - CODEN - #06496 N1 - SubjectsTermNotLitGenreText - bacteria; bioavailability; detection; ecosystems; Gowanus Canal; harbors; heavy metals; Hudson River; measurement; microorganisms; natural attenuation; New Jersey; New York; New York/New Jersey Harbor; Newark Bay; Newtown Creek; Passaic River; pollution; reclamation; sediments; soils; toxic materials; toxicity; United States ER - TY - JOUR T1 - Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study. AN - 72767859; 12477600 AB - Imaging studies in patients with Type II alcohol dependence have revealed significant reductions in dopamine (DA) D2 receptor availability. Here we assessed the effects of alcohol detoxification in DA D2 receptors in alcoholic subjects. We evaluated 14 patients with Type II alcohol dependence tested within 6 weeks of detoxification and then re-tested 1-4 months later while alcohol free. The comparison group comprised 11 healthy controls. PET was used with [11C]raclopride to measure DA D2 receptors. Eight alcoholics and all control subjects were tested with a CTI 931 PET scanner and six alcoholics with a Siemens HR+ PET scanner. Data were analyzed separately for the studies done in the different scanners. Comparisons between early and late alcohol detoxification showed no significant changes in DA D2 receptor availability (B(max)/K(d)) for the studies done with the CTI and the HR+ scanners. Comparison with controls showed lower DA D2 receptor levels in caudate and putamen in alcoholics tested during early detoxification and in caudate during late detoxification. These studies replicate previous findings of lower striatal DA D2 receptors in alcoholics than in controls and absence of significant recovery during alcohol detoxification. These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor. JF - Psychiatry research AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Maynard, Larry AU - Fowler, Joanna S AU - Jayne, Budd AU - Telang, Frank AU - Logan, Jean AU - Ding, Yu-Shin AU - Gatley, Samuel J AU - Hitzemann, Robert AU - Wong, Christopher AU - Pappas, Naome AD - Brookhaven National Laboratory, Upton, NY 11973, USA. volkow@bnl.gov Y1 - 2002/12/30/ PY - 2002 DA - 2002 Dec 30 SP - 163 EP - 172 VL - 116 IS - 3 SN - 0165-1781, 0165-1781 KW - Dopamine Antagonists KW - 0 KW - Receptors, Dopamine D2 KW - Raclopride KW - 430K3SOZ7G KW - Index Medicus KW - Humans KW - Adult KW - Tomography, Emission-Computed KW - Brain -- metabolism KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Inactivation, Metabolic -- physiology KW - Dopamine Antagonists -- pharmacokinetics KW - Raclopride -- pharmacokinetics KW - Receptors, Dopamine D2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72767859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Effects+of+alcohol+detoxification+on+dopamine+D2+receptors+in+alcoholics%3A+a+preliminary+study.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BMaynard%2C+Larry%3BFowler%2C+Joanna+S%3BJayne%2C+Budd%3BTelang%2C+Frank%3BLogan%2C+Jean%3BDing%2C+Yu-Shin%3BGatley%2C+Samuel+J%3BHitzemann%2C+Robert%3BWong%2C+Christopher%3BPappas%2C+Naome&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2002-12-30&rft.volume=116&rft.issue=3&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-01 N1 - Date created - 2002-12-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Ozone production efficiency in an urban area AN - 18725193; 5606927 AB - Ozone production efficiency can be defined as the number of molecules of oxidant (O sub(3) + NO sub(2)) produced photochemically when a molecule of NO sub(x) (NO + NO sub(2)) is oxidized. It conveys information about the conditions under which O sub(3) is formed and is an important parameter to consider when evaluating impacts from NO sub(x) emission sources. We present calculational and observational results on ozone production efficiency based on measurements made from aircraft flights in the Phoenix metropolitan area in May and June of 1998. Constrained steady state box model calculations are used to relate a ratio of O sub(3) production rate to NO sub(x) consumption rate (i.e., P(O sub(3))/P(NO sub(z))) to a VOC to NO sub(2) ratio of OH reactivity. Lagrangian calculations show how this ratio generally increases with time due to oxidation chemistry and plume dilution. City to city differences in ozone production efficiency can be attributed to corresponding differences in VOC to NO sub(2) reactivity ratio which in turn reflect emission patterns. Ozone production efficiencies derived from aircraft measurements in 20 plumes show a dependence on NO sub(x) concentration similar to that calculated for P(O sub(3))/P(NO sub(z)). Calculations are based on data from a single location but are believed to be applicable to a wide range of plumes from different areas. JF - Journal of Geophysical Research. D. Atmospheres AU - Kleinman, LI AU - Daum, PH AU - Lee, Y-N AU - Nunnermacker, L J AU - Springston AU - Weinstein-Lloyd, J AU - Rudolph, J AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York, USA Y1 - 2002/12/16/ PY - 2002 DA - 2002 Dec 16 PB - American Geophysical Union, 2000 Florida Ave., N.W. Washington DC 20009 USA, [mailto:service@agu.org], [URL:http://www.agu.org] VL - 107 IS - D23 SN - 0148-0227, 0148-0227 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - M2 551.510.43:Photochemical Processes (551.510.43) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18725193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.atitle=Ozone+production+efficiency+in+an+urban+area&rft.au=Kleinman%2C+LI%3BDaum%2C+PH%3BLee%2C+Y-N%3BNunnermacker%2C+L+J%3BSpringston%3BWeinstein-Lloyd%2C+J%3BRudolph%2C+J&rft.aulast=Kleinman&rft.aufirst=LI&rft.date=2002-12-16&rft.volume=107&rft.issue=D23&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.issn=01480227&rft_id=info:doi/10.1029%2F2002JD002529 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1029/2002JD002529 ER - TY - JOUR T1 - A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factorA AN - 18634712; 5529181 AB - We report here the crystal structure of the minimal ligand-binding segment of the Staphylococcus aureus MSCRAMM, clumping factorA. This fibrinogen- binding segment contains two similarly folded domains. The fold observed is a new variant of the immunoglobulin motif that we have called DE-variant or the DEv-IgG fold. This subgroup includes the ligand-binding domain of the collagen- binding S.aureus MSCRAMM CNA, and many other structures previously classified as jelly rolls. Structure predictions suggest that the four fibrinogen-binding S.aureus MSCRAMMs identified so far would also contain the same DEv-IgG fold. A systematic docking search using the C-terminal region of the fibrinogen [gamma]-chain as a probe suggested that a hydrophobic pocket formed between the two DEv-IgG domains of the clumping factor as the ligand- binding site. Mutagenic substitution of residues Tyr256, Pro336, Tyr338 and Lys389 in the clumping factor, which are proposed to contact the terminal residues super(408)AGDV super(411) of the [gamma]-chain, resulted in proteins with no or markedly reduced affinity for fibrinogen. JF - EMBO Journal AU - Deivanayagam, CCS AU - Wann, E R AU - Chen, W AU - Carson, M AU - Rajashankar, K R AU - Hoeoek, M AU - Narayana, SVL AD - Center for Biophysical Sciences and Engineering, School of Optometry, 244 CBSE, 1025 18th Street South, University of Alabama at Birmingham, Birmingham, AL 35294-0005, Institute of Biosciences and Technology, Center for Extracellular Matrix Biology, 2121 West Holcombe Boulevard, Texas A&M University System Health Science Center, Houston, TX 77030-303 and Brookhaven National Laboratory, Building 725A-X9, Upton, NY 119773, USA, narayana@uab.edu Y1 - 2002/12/16/ PY - 2002 DA - 2002 Dec 16 SP - 6660 EP - 6672 VL - 21 IS - 24 SN - 0261-4189, 0261-4189 KW - Microbiology Abstracts B: Bacteriology KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18634712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=A+novel+variant+of+the+immunoglobulin+fold+in+surface+adhesins+of+Staphylococcus+aureus%3A+crystal+structure+of+the+fibrinogen-binding+MSCRAMM%2C+clumping+factorA&rft.au=Deivanayagam%2C+CCS%3BWann%2C+E+R%3BChen%2C+W%3BCarson%2C+M%3BRajashankar%2C+K+R%3BHoeoek%2C+M%3BNarayana%2C+SVL&rft.aulast=Deivanayagam&rft.aufirst=CCS&rft.date=2002-12-16&rft.volume=21&rft.issue=24&rft.spage=6660&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - The orbitofrontal cortex in methamphetamine addiction: involvement in fear. AN - 72776964; 12488806 AB - We used Tellegen's Multidimensional Personality Questionnaire (MPQ) harm avoidance (fear) scale and the constraint superfactor as personality measures of inhibitory control and examined their association with glucose metabolism in the orbitofrontal gyrus at rest in 14 recently abstinent methamphetamine-dependent subjects and 22 comparison subjects. Higher MPQ scores were associated with higher relative orbitofrontal gyrus metabolism in the methamphetamine-dependent subjects. There was a tendency towards a negative association for the comparison subjects (test of coincidence of regression lines for the two subject groups: F = 3.3, df = 2,32; = 0.051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction. JF - Neuroreport AU - Goldstein, Rita Z AU - Volkow, Nora D AU - Chang, Linda AU - Wang, Gene-Jack AU - Fowler, Joanna S AU - Depue, Richard A AU - Gur, Ruben C AD - Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA. rgoldstein@bnl.gov Y1 - 2002/12/03/ PY - 2002 DA - 2002 Dec 03 SP - 2253 EP - 2257 VL - 13 IS - 17 SN - 0959-4965, 0959-4965 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Methamphetamine KW - 44RAL3456C KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Self-Injurious Behavior -- diagnostic imaging KW - Self-Injurious Behavior -- physiopathology KW - Age Factors KW - Avoidance Learning -- physiology KW - Sex Characteristics KW - Humans KW - Avoidance Learning -- drug effects KW - Self-Injurious Behavior -- metabolism KW - Brain Mapping KW - Exploratory Behavior -- drug effects KW - Adult KW - Tomography, Emission-Computed KW - Exploratory Behavior -- physiology KW - Middle Aged KW - Neuropsychological Tests KW - Female KW - Male KW - Prefrontal Cortex -- diagnostic imaging KW - Amphetamine-Related Disorders -- metabolism KW - Prefrontal Cortex -- metabolism KW - Energy Metabolism -- physiology KW - Glucose -- metabolism KW - Prefrontal Cortex -- physiopathology KW - Fear -- psychology KW - Amphetamine-Related Disorders -- diagnostic imaging KW - Fear -- drug effects KW - Amphetamine-Related Disorders -- physiopathology KW - Energy Metabolism -- drug effects KW - Methamphetamine -- pharmacology KW - Fear -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72776964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroreport&rft.atitle=The+orbitofrontal+cortex+in+methamphetamine+addiction%3A+involvement+in+fear.&rft.au=Goldstein%2C+Rita+Z%3BVolkow%2C+Nora+D%3BChang%2C+Linda%3BWang%2C+Gene-Jack%3BFowler%2C+Joanna+S%3BDepue%2C+Richard+A%3BGur%2C+Ruben+C&rft.aulast=Goldstein&rft.aufirst=Rita&rft.date=2002-12-03&rft.volume=13&rft.issue=17&rft.spage=2253&rft.isbn=&rft.btitle=&rft.title=Neuroreport&rft.issn=09594965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-15 N1 - Date created - 2002-12-18 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: J Cereb Blood Flow Metab. 1986 Aug;6(4):441-6 [3488322] Radiology. 1993 Jan;186(1):59-65 [8416587] Synapse. 1993 Jun;14(2):169-77 [8101394] J Pharmacol Exp Ther. 1985 Dec;235(3):677-82 [4078729] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] Neurosci Lett. 2002 Aug 16;328(3):233-6 [12147314] Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2450-4 [11842195] J Neurol Neurosurg Psychiatry. 1994 Dec;57(12):1518-24 [7798983] Rev Neurol (Paris). 1986;142(11):851-5 [2881340] Cereb Cortex. 2000 Mar;10(3):318-25 [10731226] Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] J Addict Dis. 1996;15(4):55-71 [8943582] Br J Psychiatry Suppl. 1998;(35):26-37 [9829024] Am J Psychiatry. 1999 Mar;156(3):470-3 [10080567] Neuroreport. 2001 Aug 8;12(11):2595-9 [11496155] Behav Brain Sci. 1999 Jun;22(3):491-517; discussion 518-69 [11301519] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Clustered DNA damages induced in human hematopoietic cells by low doses of ionizing radiation. AN - 72901993; 12793749 AB - Ionizing radiation induces clusters of DNA damages--oxidized bases, abasic sites and strand breaks--on opposing strands within a few helical turns. Such damages have been postulated to be difficult to repair, as are double strand breaks (one type of cluster). We have shown that low doses of low and high linear energy transfer (LET) radiation induce such damage clusters in human cells. In human cells, DSB are about 30% of the total of complex damages, and the levels of DSBs and oxidized pyrimidine clusters are similar. The dose responses for cluster induction in cells can be described by a linear relationship, implying that even low doses of ionizing radiation can produce clustered damages. Studies are in progress to determine whether clusters can be produced by mechanisms other than ionizing radiation, as well as the levels of various cluster types formed by low and high LET radiation. JF - Journal of radiation research AU - Sutherland, Betsy M AU - Bennett, Paula V AU - Cintron-Torres, Nela AU - Hada, Megumi AU - Trunk, John AU - Monteleone, Denise AU - Sutherland, John C AU - Laval, Jacques AU - Stanislaus, Marisha AU - Gewirtz, Alan AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. bms@bnl.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - S149 EP - S152 VL - 43 Suppl SN - 0449-3060, 0449-3060 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Humans KW - Dose-Response Relationship, Radiation KW - DNA -- radiation effects KW - Linear Energy Transfer KW - Cell Line KW - Multigene Family -- radiation effects KW - Monocytes -- physiology KW - DNA Damage KW - Monocytes -- radiation effects KW - Hematopoiesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72901993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+radiation+research&rft.atitle=Clustered+DNA+damages+induced+in+human+hematopoietic+cells+by+low+doses+of+ionizing+radiation.&rft.au=Sutherland%2C+Betsy+M%3BBennett%2C+Paula+V%3BCintron-Torres%2C+Nela%3BHada%2C+Megumi%3BTrunk%2C+John%3BMonteleone%2C+Denise%3BSutherland%2C+John+C%3BLaval%2C+Jacques%3BStanislaus%2C+Marisha%3BGewirtz%2C+Alan&rft.aulast=Sutherland&rft.aufirst=Betsy&rft.date=2002-12-01&rft.volume=43+Suppl&rft.issue=&rft.spage=S149&rft.isbn=&rft.btitle=&rft.title=Journal+of+radiation+research&rft.issn=04493060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-15 N1 - Date created - 2003-06-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies. AN - 72745935; 12468018 AB - Methylphenidate is the most commonly prescribed drug for the treatment of ADHD. We have used positron emission tomography to assess the role that methylphenidate's effects in brain dopamine have on its therapeutic and reinforcing effects. We have documented that in the human brain therapeutic doses of methylphenidate block more than 50% of the dopamine transporters and significantly enhance extracellular DA, an effect that appears to be modulated by the rate of DA release. Thus, we postulate that methylphenidate's therapeutic effects are in part due to amplification of DA signals, that variability in responses is in part due to differences in DA tone and that methylphenidate's effects are context dependent. Methylphenidate-induced increases in DA are also associated with its reinforcing effects but only when this occurs rapidly, as with intravenous administration. Moreover, abuse of methylphenidate is constrained by its long half-life, which we postulate limits the frequency at which it can be administered. JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene Jack AU - Ding, Yu Shin AU - Gatley, Samuel J AD - Medical Department Brookhaven National Laboratory, Upton, NY 11973, USA. volkow@bnl.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 557 EP - 566 VL - 12 IS - 6 SN - 0924-977X, 0924-977X KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Dopamine Uptake Inhibitors KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Methylphenidate KW - 207ZZ9QZ49 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Attention Deficit Disorder with Hyperactivity -- psychology KW - Animals KW - Humans KW - Tomography, Emission-Computed KW - Attention Deficit Disorder with Hyperactivity -- diagnostic imaging KW - Substance-Related Disorders -- metabolism KW - Attention Deficit Disorder with Hyperactivity -- metabolism KW - Substance-Related Disorders -- psychology KW - Membrane Transport Proteins -- metabolism KW - Methylphenidate -- administration & dosage KW - Methylphenidate -- pharmacology KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Reinforcement (Psychology) KW - Methylphenidate -- pharmacokinetics KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Dopamine Uptake Inhibitors -- pharmacokinetics KW - Brain -- diagnostic imaging KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72745935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.atitle=Role+of+dopamine+in+the+therapeutic+and+reinforcing+effects+of+methylphenidate+in+humans%3A+results+from+imaging+studies.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene+Jack%3BDing%2C+Yu+Shin%3BGatley%2C+Samuel+J&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2002-12-01&rft.volume=12&rft.issue=6&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.issn=0924977X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-25 N1 - Date created - 2002-12-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - CPAPER T1 - Neuroimaging in HIV-related brain disease AN - 39537201; 3712438 AU - Chang, L Y1 - 2002/11/21/ PY - 2002 DA - 2002 Nov 21 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neuroimaging+in+HIV-related+brain+disease&rft.au=Chang%2C+L&rft.aulast=Chang&rft.aufirst=L&rft.date=2002-11-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Neuroscience 2002, c/o AKM Congress Service GmbH, Rheinterrasse Dusseldorf, Joseph-Beuys-Ufer 33, 40479 Dusseldorf, Germany; phone: 49 (0) 211-49 77 712; fax: 49 (0) 211-49 77 743. Paper No. 106 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Thermodynamics of common atmospheric particles on the nanoscale AN - 821965391; 2011-008226 JF - Eos, Transactions, American Geophysical Union AU - Onasch, Timothy AU - Han, Jeong-ho AU - Oatis, Susan AU - Brechtel, Frederick AU - Imre, Dan G AU - Anonymous Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 106 PB - American Geophysical Union, Washington, DC VL - 83 IS - 47, Suppl. SN - 0096-3941, 0096-3941 KW - water KW - atmosphere KW - adsorption KW - temperature KW - size KW - deliquescence KW - humidity KW - efflorescence KW - volume KW - aerosols KW - thermodynamic properties KW - particles KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821965391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Thermodynamics+of+common+atmospheric+particles+on+the+nanoscale&rft.au=Onasch%2C+Timothy%3BHan%2C+Jeong-ho%3BOatis%2C+Susan%3BBrechtel%2C+Frederick%3BImre%2C+Dan+G%3BAnonymous&rft.aulast=Onasch&rft.aufirst=Timothy&rft.date=2002-11-01&rft.volume=83&rft.issue=47%2C+Suppl.&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2002 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2011-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - adsorption; aerosols; atmosphere; deliquescence; efflorescence; humidity; particles; size; temperature; thermodynamic properties; volume; water ER - TY - JOUR T1 - Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies. AN - 72837057; 12559839 AB - Drug addiction is characterized by a set of recurring processes (intoxication, withdrawal, craving) that lead to the relapsing nature of the disorder. We have used positron emission tomography to investigate in humans the role of dopamine (DA) and the brain circuits it regulates in these processes. We have shown that increases in DA are associated with the subjective reports of drug reinforcement corroborating the relevance of drug-induced DA increases in the rewarding effects of drugs in humans. During withdrawal we have shown in drug abusers significant reductions in DA D2 receptors and in DA release. We postulate that this hypodopaminergic state would result in a decreased sensitivity to natural reinforcers perpetuating the use of the drug as a means to compensate for this deficit and contributing to the anhedonia and dysphoria seen during withdrawal. Because the D2 reductions are associated with decreased activity in the anterior cingulate gyrus and in the orbitofrontal cortex we postulate that this is one of the mechanisms by which DA disruption leads to compulsive drug administration and the lack of control over drug intake in the drug-addicted individual. This is supported by studies showing that during craving these frontal regions become hyperactive in proportion to the intensity of the craving. Craving is also associated with activation of memory circuits including the amygdala (implicated in conditioned learning), hippocampus (implicated in declarative learning), and dorsal striatum (implicated in habit learning) all of which receive DA innervation. We therefore postulate that dopamine contributes to addiction by disrupting the frontal cortical circuits that regulate motivation, drive, and self-control and by memory circuits that increase the motivational salience of the drug and drug-associated stimuli. JF - Neurobiology of learning and memory AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene-Jack AU - Goldstein, Rita Z AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 610 EP - 624 VL - 78 IS - 3 SN - 1074-7427, 1074-7427 KW - Narcotics KW - 0 KW - Receptors, Dopamine KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Receptors, Dopamine -- drug effects KW - Amygdala -- metabolism KW - Substance Withdrawal Syndrome -- etiology KW - Neural Pathways -- metabolism KW - Humans KW - Corpus Striatum -- metabolism KW - Hippocampus -- metabolism KW - Tomography, Emission-Computed KW - Narcotics -- adverse effects KW - Frontal Lobe -- physiopathology KW - Memory Disorders -- physiopathology KW - Frontal Lobe -- metabolism KW - Dopamine -- metabolism KW - Substance-Related Disorders -- metabolism KW - Memory Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72837057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+learning+and+memory&rft.atitle=Role+of+dopamine%2C+the+frontal+cortex+and+memory+circuits+in+drug+addiction%3A+insight+from+imaging+studies.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack%3BGoldstein%2C+Rita+Z&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2002-11-01&rft.volume=78&rft.issue=3&rft.spage=610&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+learning+and+memory&rft.issn=10747427&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-21 N1 - Date created - 2003-01-31 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Carbon K-edge scanning transmission X-ray spectromicroscopy (STXM) of uranium binding to bacterial cells AN - 51715508; 2005-042222 JF - Eos, Transactions, American Geophysical Union AU - Gillow, J AU - Wirick, S AU - Feser, M AU - Jacobsen, C AU - Francis, A AU - Anonymous Y1 - 2002/11// PY - 2002 DA - November 2002 SP - F1397 EP - F1398 PB - American Geophysical Union, Washington, DC VL - 83 IS - 47, Suppl. SN - 0096-3941, 0096-3941 KW - XANES spectra KW - laboratory studies KW - sorption KW - experimental studies KW - metals KW - carbon KW - bacteria KW - uranium KW - spectra KW - actinides KW - X-ray spectra KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51715508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Carbon+K-edge+scanning+transmission+X-ray+spectromicroscopy+%28STXM%29+of+uranium+binding+to+bacterial+cells&rft.au=Gillow%2C+J%3BWirick%2C+S%3BFeser%2C+M%3BJacobsen%2C+C%3BFrancis%2C+A%3BAnonymous&rft.aulast=Gillow&rft.aufirst=J&rft.date=2002-11-01&rft.volume=83&rft.issue=47%2C+Suppl.&rft.spage=F1397&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2002 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - actinides; bacteria; carbon; experimental studies; laboratory studies; metals; sorption; spectra; uranium; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Time-resolved structural analysis of cation exchange reactions in birnessite using synchrotron XRD AN - 51689780; 2005-056162 JF - Eos, Transactions, American Geophysical Union AU - Lopano, Christina L AU - Heaney, Peter J AU - Post, Jeffrey E AU - Hanson, Jonathan C AU - Lee, Yongjae AU - Komarneni, Sridhar AU - Anonymous Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 1425 PB - American Geophysical Union, Washington, DC VL - 83 IS - 47, Suppl. SN - 0096-3941, 0096-3941 KW - soils KW - experimental studies KW - X-ray diffraction data KW - substitution KW - crystal structure KW - Rietveld refinement KW - ground water KW - synchrotron radiation KW - laboratory studies KW - birnessite KW - time factor KW - oxides KW - cations KW - applications KW - lattice parameters KW - ion exchange KW - crystal chemistry KW - industrial minerals KW - geochemistry KW - synthetic materials KW - 01A:General mineralogy KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51689780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Time-resolved+structural+analysis+of+cation+exchange+reactions+in+birnessite+using+synchrotron+XRD&rft.au=Lopano%2C+Christina+L%3BHeaney%2C+Peter+J%3BPost%2C+Jeffrey+E%3BHanson%2C+Jonathan+C%3BLee%2C+Yongjae%3BKomarneni%2C+Sridhar%3BAnonymous&rft.aulast=Lopano&rft.aufirst=Christina&rft.date=2002-11-01&rft.volume=83&rft.issue=47%2C+Suppl.&rft.spage=1425&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2002 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - applications; birnessite; cations; crystal chemistry; crystal structure; experimental studies; geochemistry; ground water; industrial minerals; ion exchange; laboratory studies; lattice parameters; oxides; Rietveld refinement; soils; substitution; synchrotron radiation; synthetic materials; time factor; X-ray diffraction data ER - TY - JOUR T1 - Thermal analyses of magnesioferrite AN - 51526053; 2006-086195 JF - Eos, Transactions, American Geophysical Union AU - Antao, S M AU - Hanson, J AU - Hassan, I AU - Chen, J AU - Parise, J B AU - Anonymous Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 1 PB - American Geophysical Union, Washington, DC VL - 83 IS - 47, Suppl. SN - 0096-3941, 0096-3941 KW - X-ray diffraction data KW - thermogravimetric analysis KW - thermal properties KW - spinel KW - Rietveld refinement KW - temperature KW - thermal analysis KW - reagents KW - magnesioferrite KW - oxides KW - synchrotrons KW - thermal analysis data KW - high temperature KW - P-T conditions KW - calorimetry KW - 17A:General geophysics KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51526053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Thermal+analyses+of+magnesioferrite&rft.au=Antao%2C+S+M%3BHanson%2C+J%3BHassan%2C+I%3BChen%2C+J%3BParise%2C+J+B%3BAnonymous&rft.aulast=Antao&rft.aufirst=S&rft.date=2002-11-01&rft.volume=83&rft.issue=47%2C+Suppl.&rft.spage=F606&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2002 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - calorimetry; high temperature; magnesioferrite; oxides; P-T conditions; reagents; Rietveld refinement; spinel; synchrotrons; temperature; thermal analysis; thermal analysis data; thermal properties; thermogravimetric analysis; X-ray diffraction data ER - TY - JOUR T1 - Genomic Signature Tags (GSTs): A System for Profiling Genomic DNA AN - 18557231; 5522781 AB - Genomic signature tags (GSTs) are the products of a method we have developed for identifying and quantitatively analyzing genomic DNAs. The DNA is initially fragmented with a type II restriction enzyme. An oligonucleotide adaptor containing a recognition site for MmeI, a type IIS restriction enzyme, is then used to release 21-bp tags from fixed positions in the DNA relative to the sites recognized by the fragmenting enzyme. These tags are PCR-amplified, purified, concatenated, and then cloned and sequenced. The tag sequences and abundances are used to create a high-resolution GST sequence profile of the genomic DNA. GSTs are shown to be long enough for use as oligonucleotide primers to amplify adjacent segments of the DNA, which can then be sequenced to provide additional nucleotide information or used as probes to identify specific clones in metagenomic libraries. GST analysis of the 4.7-Mb Yersinia pestis EV766 genome using BamHI as the fragmenting enzyme and NlaIII as the tagging enzyme validated the precision of our approach. The GST profile predicts that this strain has several changes relative to the archetype CO92 strain, including deletion of a 57-kb region of the chromosome known to be an unstable pathogenicity island. JF - Genome Research AU - Dunn, J J AU - McCorkle AU - Praissman, LA AU - Hind, G AU - Van Der Lelie, D AU - Bahou, W F AU - Gnatenko, D V AU - Krause, M K AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA, jdunn@bnl.gov Y1 - 2002/11// PY - 2002 DA - Nov 2002 SP - 1756 EP - 1765 VL - 12 IS - 11 SN - 1054-9803, 1054-9803 KW - pathogenicity islands KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - N 14610:Occurrence, isolation & assay KW - G 07191:Analysis techniques KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18557231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=Genomic+Signature+Tags+%28GSTs%29%3A+A+System+for+Profiling+Genomic+DNA&rft.au=Dunn%2C+J+J%3BMcCorkle%3BPraissman%2C+LA%3BHind%2C+G%3BVan+Der+Lelie%2C+D%3BBahou%2C+W+F%3BGnatenko%2C+D+V%3BKrause%2C+M+K&rft.aulast=Dunn&rft.aufirst=J&rft.date=2002-11-01&rft.volume=12&rft.issue=11&rft.spage=1756&rft.isbn=&rft.btitle=&rft.title=Genome+Research&rft.issn=10549803&rft_id=info:doi/10.1101%2Fgr.306102 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1101/gr.306102 ER - TY - JOUR T1 - Anthropogenic aerosols: Indirect warming effect from dispersion forcing AN - 19923819; 5467235 AB - Anthropogenic aerosols enhance cloud reflectivity by increasing the number concentration of cloud droplets, leading to a cooling effect on climate that is referred to as the Twomey effect. Here we show that anthropogenic aerosols exert an additional effect on cloud properties that is derived from changes in the spectral shape of the size distribution of cloud droplets in polluted air and acts to diminish this cooling. This finding could help to improve our understanding of the indirect aerosol effect and its treatment in climate modelling. JF - Nature AU - Liu, Y AU - Daum, PH AD - Brookhaven National Laboratory, Upton, New York 11973, USA, lyg@bnl.gov Y1 - 2002/10/10/ PY - 2002 DA - 2002 Oct 10 SP - 580 EP - 581 PB - Macmillan Publishers Ltd. VL - 419 IS - 6907 SN - 0028-0836, 0028-0836 KW - Twomey effect KW - Sustainability Science Abstracts; Pollution Abstracts; Oceanic Abstracts; Human Population; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Particle size KW - Atmospheric particulates KW - Aerosols KW - Reflectance KW - anthropogenic factors KW - Albedo KW - Climatic changes KW - Man-induced effects KW - Pollution effects KW - Cloud physics KW - Air pollution KW - Clouds KW - Global warming KW - Population-environment relations KW - Size distribution KW - Q2 09243:Structure, mechanics and thermodynamics KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - O 2070:Meteorology KW - Q5 08521:Mechanical and natural changes KW - O 4060:Pollution - Environment KW - M1 110:Population-Environment Relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19923819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Anthropogenic+aerosols%3A+Indirect+warming+effect+from+dispersion+forcing&rft.au=Liu%2C+Y%3BDaum%2C+PH&rft.aulast=Liu&rft.aufirst=Y&rft.date=2002-10-10&rft.volume=419&rft.issue=6907&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-10-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Clouds; Particle size; Air pollution; Atmospheric particulates; Aerosols; Reflectance; Albedo; Climatic changes; Pollution effects; Man-induced effects; Cloud physics; Size distribution; Global warming; Population-environment relations; anthropogenic factors ER - TY - JOUR T1 - The role of dopamine in motivation for food in humans: implications for obesity. AN - 72193095; 12387683 AB - Obesity is a major public health problem. The increasing number of obese individuals in the US adds urgency to the efforts to understand the mechanisms underlying pathological overeating. Imaging studies using positron emission tomography implicate the involvement of brain dopamine (DA) in normal and pathological food intake in humans. In normal body weight, fasting subjects, food presentation that could not be consumed was associated with increases in striatal extracellular DA, which provides evidence of an involvement of DA in non-hedonic motivational properties of food intake. In pathologically obese subjects, the authors showed reductions in striatal D2 receptor availability that were inversely associated with the weight of the subject. The involvement of the DA system in reward and reinforcement has led to the hypothesis that low brain DA activity in obese subjects predisposes them to excessive use of food. A better understanding of the role of the DA system in the motivation for food intake will help the development of better therapeutic interventions. JF - Expert opinion on therapeutic targets AU - Wang, Gene-Jack AU - Volkow, Nora D AU - Fowler, Joanna S AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. gjwang@bnl.gov Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 601 EP - 609 VL - 6 IS - 5 KW - Dopamine Agonists KW - 0 KW - Dopamine Antagonists KW - Dopamine D2 Receptor Antagonists KW - Receptors, Dopamine KW - Receptors, Dopamine D2 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Substance-Related Disorders -- physiopathology KW - Receptors, Dopamine -- drug effects KW - Animals KW - Hypothalamus -- physiology KW - Feeding and Eating Disorders -- genetics KW - Limbic System -- physiology KW - Methylphenidate -- pharmacology KW - Brain Chemistry KW - Corpus Striatum -- metabolism KW - Humans KW - Receptors, Dopamine D2 -- physiology KW - Satiation -- physiology KW - Rats KW - Receptors, Dopamine -- physiology KW - Reward KW - Dopamine Agonists -- pharmacology KW - Feeding and Eating Disorders -- physiopathology KW - Dopamine Antagonists -- toxicity KW - Receptors, Dopamine D2 -- genetics KW - Substance-Related Disorders -- genetics KW - Obesity -- drug therapy KW - Obesity -- prevention & control KW - Obesity -- etiology KW - Feeding Behavior -- physiology KW - Dopamine -- physiology KW - Appetite -- drug effects KW - Obesity -- physiopathology KW - Obesity -- chemically induced KW - Feeding Behavior -- drug effects KW - Appetite -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72193095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+therapeutic+targets&rft.atitle=The+role+of+dopamine+in+motivation+for+food+in+humans%3A+implications+for+obesity.&rft.au=Wang%2C+Gene-Jack%3BVolkow%2C+Nora+D%3BFowler%2C+Joanna+S&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2002-10-01&rft.volume=6&rft.issue=5&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+therapeutic+targets&rft.issn=1744-7631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-25 N1 - Date created - 2002-10-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. AN - 72139389; 12359667 AB - OBJECTIVEStudies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction.METHODAn integrated model of drug addiction that encompasses intoxication, bingeing, withdrawal, and craving is proposed. This model and findings from neuroimaging studies on the behavioral, cognitive, and emotional processes that are at the core of drug addiction were used to analyze the involvement of frontal structures in drug addiction.RESULTSThe orbitofrontal cortex and the anterior cingulate gyrus, which are regions neuroanatomically connected with limbic structures, are the frontal cortical areas most frequently implicated in drug addiction. They are activated in addicted subjects during intoxication, craving, and bingeing, and they are deactivated during withdrawal. These regions are also involved in higher-order cognitive and motivational functions, such as the ability to track, update, and modulate the salience of a reinforcer as a function of context and expectation and the ability to control and inhibit prepotent responses.CONCLUSIONSThese results imply that addiction connotes cortically regulated cognitive and emotional processes, which result in the overvaluing of drug reinforcers, the undervaluing of alternative reinforcers, and deficits in inhibitory control for drug responses. These changes in addiction, which the authors call I-RISA (impaired response inhibition and salience attribution), expand the traditional concepts of drug dependence that emphasize limbic-regulated responses to pleasure and reward. JF - The American journal of psychiatry AU - Goldstein, Rita Z AU - Volkow, Nora D AD - Medical Research, Brookhaven National Laboratory, Bldg. 490, 30 Bell Avenue, Upton, NY 11973, USA. rgoldstein@bnl.gov Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 1642 EP - 1652 VL - 159 IS - 10 SN - 0002-953X, 0002-953X KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Limbic System -- physiopathology KW - Substance Withdrawal Syndrome -- physiopathology KW - Cerebral Cortex -- metabolism KW - Humans KW - Reinforcement (Psychology) KW - Dopamine -- physiology KW - Terminology as Topic KW - Behavior, Addictive -- physiopathology KW - Cerebral Cortex -- physiopathology KW - Compulsive Behavior -- physiopathology KW - Syndrome KW - Cocaine-Related Disorders -- physiopathology KW - Tomography, Emission-Computed KW - Cocaine-Related Disorders -- metabolism KW - Models, Theoretical KW - Substance-Related Disorders -- physiopathology KW - Frontal Lobe -- physiopathology KW - Frontal Lobe -- diagnostic imaging KW - Frontal Lobe -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72139389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Drug+addiction+and+its+underlying+neurobiological+basis%3A+neuroimaging+evidence+for+the+involvement+of+the+frontal+cortex.&rft.au=Goldstein%2C+Rita+Z%3BVolkow%2C+Nora+D&rft.aulast=Goldstein&rft.aufirst=Rita&rft.date=2002-10-01&rft.volume=159&rft.issue=10&rft.spage=1642&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-23 N1 - Date created - 2002-10-02 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] J Psychoactive Drugs. 2000 Nov;32 Suppl:i-iv, 1-112 [11280926] Annu Rev Neurosci. 2001;24:167-202 [11283309] J Neurosci. 2001 Apr 15;21(8):2793-8 [11306631] J Neurosci. 2001 Jun 1;21(11):4090-103 [11356897] Neuron. 2001 May;30(2):619-39 [11395019] Neuroreport. 2001 Aug 8;12(11):2595-9 [11496155] J Neurochem. 2001 Sep;78(5):1094-103 [11553683] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] Biol Psychiatry. 2002 Jan 15;51(2):134-42 [11822992] Psychopharmacology (Berl). 1981;73(4):318-22 [6789351] J Pharmacol Exp Ther. 1985 Dec;235(3):677-82 [4078729] Pharmacol Biochem Behav. 1986 Jul;25(1):191-9 [3018792] Science. 1987 Sep 4;237(4819):1219-23 [2820058] Psychiatry Res. 1988 May;24(2):201-9 [3261427] Br J Psychiatry. 1988 May;152:641-8 [3262397] Synapse. 1989;3(1):48-54 [2537539] Pharmacol Rev. 1989 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A 20-m core drilled in the south basin of Zabuye Salt Lake was analyzed for inorganic and organic carbon and total sulfur contents, delta (super 13) C and delta (super 18) O values of carbonates. Our results indicate that climatic changes have led to a drastic negative shift of stable isotope ratios at the transition between the Last Full Glacial and the postglacial phase during Later Pleistocene times ( approximately 16.2 kyr BP), and a rapid positive shift at the transition from Pleistocene to Holocene ( approximately 10.6 kyr BP). The first shift is marked by the drop of delta (super 18) O (sub carb) values of about 10 per mil (from +2 to -8 per mil) and delta (super 13) C (sub carb) values of about 3 per mil (from 5 to 2 per mil). The second shift which occurred at the transition from Pleistocene to Holocene was of similar magnitude but in the opposite direction. Isotope data, combined with total organic and inorganic carbon contents and the lithological composition of the core, suggest this lake was an alluvial pre-lake environment prior to ca. 28 (super 14) C kyr BP. During ca. 28-16.2 (super 14) C kyr BP, Zabuye Lake was likely a moderately deep lake with limited outflow. The cool and arid glacial climate led the lake level to drop drastically. Extended residence time overwhelmed the lower temperature and caused a steady increase of delta (super 13) C (sub carb) and delta (super 18) O (sub carb) values and total inorganic carbon content in the sediments. During ca. 16.2-10.6 (super 14) C kyr BP, this lake probably overflowed and received abundant recharge from melting glaciers when the deglaciation was in its full speed. A spike of markedly enhanced delta (super 13) C (sub carb) and delta (super 18) O (sub carb) is seen at approximately 11.5 kyr BP, probably due to the isotopic effects left behind by the short but severe Younger Dryas (YD) event. After ca. 10.6 (super 14) C kyr BP, Zabuye Lake probably closed its surface outflow, due to strong desiccation and drastic climate warming. The Early and Middle Holocene were characterized by unstable climatic conditions with alternating warmer/cooler episodes as indicated by the severe fluctuations of total organic carbon, delta (super 13) C and delta (super 18) O values. A hypersaline salt lake environment was finally formed at Zabuye after approximately 5 (super 14) C kyr BP when the mirabilite and halite concentrations steadily increased and became the dominant minerals in the sediments. Severe imbalance of inflow/outflow resulted in the drastic increase of total sulfur, delta (super 13) C (sub carb) and delta (super 18) O (sub carb) values and dominance of halite in the lake since ca. 3.8 kyr BP to present. JF - Earth and Planetary Science Letters AU - Wang, R L AU - Scarpitta, S C AU - Zhang, S C AU - Zheng, M P Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 461 EP - 477 PB - Elsevier, Amsterdam VL - 203 IS - 1 SN - 0012-821X, 0012-821X KW - last glacial maximum KW - Far East KW - oxygen KW - glaciation KW - isotopes KW - postglacial environment KW - lakes KW - paleoclimatology KW - Holocene KW - stable isotopes KW - deglaciation KW - cores KW - climate change KW - upper Pleistocene KW - Cenozoic KW - radioactive isotopes KW - melting KW - paleolimnology KW - dates KW - Xizang China KW - total organic carbon KW - carbon KW - Tibetan Plateau KW - glacial environment KW - sediments KW - absolute age KW - organic carbon KW - Asia KW - geochemistry KW - China KW - salt lakes KW - Quaternary KW - paleohydrology KW - isotope ratios KW - C-13/C-12 KW - glaciers KW - O-18/O-16 KW - inorganic materials KW - organic compounds KW - Zabuye Lake KW - residence time KW - lacustrine environment KW - sulfur KW - Pleistocene KW - glacial geology KW - C-14 KW - lake sediments KW - 24:Quaternary geology KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52035049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Earth+and+Planetary+Science+Letters&rft.atitle=Later+Pleistocene%2FHolocene+climate+conditions+of+Qinghai-Xizhang+Plateau+%28Tibet%29+based+on+carbon+and+oxygen+stable+isotopes+of+Zabuye+Lake+sediments&rft.au=Wang%2C+R+L%3BScarpitta%2C+S+C%3BZhang%2C+S+C%3BZheng%2C+M+P&rft.aulast=Wang&rft.aufirst=R&rft.date=2002-10-01&rft.volume=203&rft.issue=1&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Earth+and+Planetary+Science+Letters&rft.issn=0012821X&rft_id=info:doi/10.1016%2FS0012-821X%2802%2900829-4 L2 - http://www.sciencedirect.com/science/journal/0012821X LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2003-01-01 N1 - Number of references - 41 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - EPSLA2 N1 - SubjectsTermNotLitGenreText - absolute age; Asia; C-13/C-12; C-14; carbon; Cenozoic; China; climate change; cores; dates; deglaciation; Far East; geochemistry; glacial environment; glacial geology; glaciation; glaciers; Holocene; inorganic materials; isotope ratios; isotopes; lacustrine environment; lake sediments; lakes; last glacial maximum; melting; O-18/O-16; organic carbon; organic compounds; oxygen; paleoclimatology; paleohydrology; paleolimnology; Pleistocene; postglacial environment; Quaternary; radioactive isotopes; residence time; salt lakes; sediments; stable isotopes; sulfur; Tibetan Plateau; total organic carbon; upper Pleistocene; Xizang China; Zabuye Lake DO - http://dx.doi.org/10.1016/S0012-821X(02)00829-4 ER - TY - BOOK T1 - A Scoping Study on the Core Damage Frequency Impact of Cable Failures Due to Harsh Environment in a PWR and a BWR AN - 21022459; 10882780 AB - The automatic and manual operation of safety systems in a nuclear power plant (NPP) rely on cables and related equipment, such as electrical penetration assemblies and terminations, for power, control, and instrumentation signals. During an accident that creates a harsh environment, the cables need to perform reliably to operate the electrical equipment to meet the system's performance requirements. The performance capability of cables during accidents is addressed through environmental qualification of electrical equipment. In this paper, we present a scoping study of the impact of cable failures on the NPP's risk using core damage frequency (CDF) as the risk measure. We assess the impact of cable failures due to the harsh environment using the probabilistic risk assessment (PRA) model of the internal initiators in a plant. However, in the PRA of NPPs, the cable reliability in a harsh environment is typically assumed to remain unaffected. Also, typically, cables are not explicitly modeled in a PRA, and the effect of their failure on hardware and operator's actions is not directly addressed. We use existing PRA models to evaluate the impact of cable failures through the modeled component's and operator's actions. Several assumptions are made. Sensitivity analyses are conducted to assess the impact of failures of cables providing different functions inside the containment. The impact on CDF and the accident sequences that become dominant contributors when cables fail are studied. The relative CDF significance of cables providing different functions is obtained. A pressurized water reactor (PWR) plant, Surry Nuclear Power Station, and a boiling water reactor (BWR) plant, Peach Bottom Station, are studied. JF - WIRE SYSTEM AGING. AU - Samanta, P K AU - Martinez-Guridi, G Y1 - 2002/10// PY - 2002 DA - Oct 2002 PB - U.S. Nuclear Regulatory Commission KW - Health & Safety Science Abstracts KW - Risk assessment KW - safety systems KW - Prunus KW - commissions KW - Accidents KW - sensitivity analysis KW - Power plants KW - Containment KW - aging KW - Conferences KW - Nuclear power plants KW - USA KW - Nuclear reactors KW - electrical equipment KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21022459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Samanta%2C+P+K%3BMartinez-Guridi%2C+G&rft.aulast=Samanta&rft.aufirst=P&rft.date=2002-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Scoping+Study+on+the+Core+Damage+Frequency+Impact+of+Cable+Failures+Due+to+Harsh+Environment+in+a+PWR+and+a+BWR&rft.title=A+Scoping+Study+on+the+Core+Damage+Frequency+Impact+of+Cable+Failures+Due+to+Harsh+Environment+in+a+PWR+and+a+BWR&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies. AN - 72519977; 12394411 AB - The involvement of dopamine (DA) in drug reinforcement is well established, but much less in known about its contribution to addiction. We have used positron emission tomography to investigate in humans the role of DA in drug reinforcement, addiction and drug vulnerability. We have shown that during drug intoxication increases in striatal DA are associated with the drug's reinforcing effects only if the DA changes occur rapidly. These results corroborate the relevance of drug-induced DA increases and of pharmacokinetics in the rewarding effects of drugs in humans. During withdrawal, we have shown significant reductions in DA D(2) receptors and in DA release in drug abusers, which is likely to result in decreased sensitivity to non-drug-related reinforcing stimuli. The DA D(2) reductions were associated with decreased activity in the orbitofrontal cortex, which we postulate is one of the mechanisms underlying compulsive drug administration in the addict. In fact, during craving the orbitofrontal cortex becomes hyperactive in proportion to the desire for the drug. In non-drug-abusing subjects striatal DA D(2) receptors levels predicted the reinforcing responses to stimulant drugs, providing evidence that striatal DA D(2) receptors modulate reinforcing responses to stimulants in humans and may contribute to the predisposition for drug self-administration. JF - Behavioural pharmacology AU - Volkow, N D AU - Fowler, J S AU - Wang, G-J AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 355 EP - 366 VL - 13 IS - 5-6 SN - 0955-8810, 0955-8810 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Receptors, Dopamine D2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Neurons -- metabolism KW - Humans KW - Tomography, Emission-Computed KW - Membrane Transport Proteins -- drug effects KW - Membrane Transport Proteins -- metabolism KW - Receptors, Dopamine D2 -- metabolism KW - Substance-Related Disorders -- pathology KW - Reinforcement (Psychology) KW - Dopamine -- physiology KW - Dopamine -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72519977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Role+of+dopamine+in+drug+reinforcement+and+addiction+in+humans%3A+results+from+imaging+studies.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWang%2C+G-J&rft.aulast=Volkow&rft.aufirst=N&rft.date=2002-09-01&rft.volume=13&rft.issue=5-6&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-23 N1 - Date created - 2002-10-23 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment On: Behav Pharmacol. 2002 Sep;13(5-6):371-7 [12394413] Behav Pharmacol. 2002 Sep;13(5-6):367-70 [12394412] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - A temperature-resolved synchrotron X-ray diffraction study of thermal decomposition in end-member and cation-exchanged hydrotalcite AN - 51681339; 2005-063929 JF - Abstracts of the ... General Meeting of the International Mineralogical Association AU - Heaney, P J AU - Post, Jeffrey E AU - Hanson, J AU - Komarneni, S AU - Parsons, Ian Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 91 EP - 92 PB - International Mineralogical Association, [location varies] VL - 18 KW - zinc KW - alkaline earth metals KW - magnesium KW - hydrotalcite KW - experimental studies KW - X-ray diffraction data KW - thermal alteration KW - copper KW - Rietveld refinement KW - powder method KW - synchrotron radiation KW - laboratory studies KW - metals KW - cations KW - ion exchange KW - crystal chemistry KW - carbonates KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51681339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+the+...+General+Meeting+of+the+International+Mineralogical+Association&rft.atitle=A+temperature-resolved+synchrotron+X-ray+diffraction+study+of+thermal+decomposition+in+end-member+and+cation-exchanged+hydrotalcite&rft.au=Heaney%2C+P+J%3BPost%2C+Jeffrey+E%3BHanson%2C+J%3BKomarneni%2C+S%3BParsons%2C+Ian&rft.aulast=Heaney&rft.aufirst=P&rft.date=2002-09-01&rft.volume=18&rft.issue=&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+the+...+General+Meeting+of+the+International+Mineralogical+Association&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 18th general meeting of the International Mineralogical Association N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - #03852 N1 - SubjectsTermNotLitGenreText - alkaline earth metals; carbonates; cations; copper; crystal chemistry; experimental studies; hydrotalcite; ion exchange; laboratory studies; magnesium; metals; powder method; Rietveld refinement; synchrotron radiation; thermal alteration; X-ray diffraction data; zinc ER - TY - JOUR T1 - Neutron and temperature-resolved synchrotron X-ray powder diffraction study of akaganeite AN - 51679101; 2005-063917 JF - Abstracts of the ... General Meeting of the International Mineralogical Association AU - Post, Jeffrey E AU - Heaney, P J AU - Von Dreele, R B AU - Hanson, J AU - Parsons, Ian Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 88 EP - 89 PB - International Mineralogical Association, [location varies] VL - 18 KW - chlorine KW - experimental studies KW - refinement KW - X-ray diffraction data KW - halogens KW - unit cell KW - crystal structure KW - Rietveld refinement KW - powder method KW - temperature KW - order-disorder KW - synchrotron radiation KW - laboratory studies KW - akaganeite KW - hydrogen KW - neutron diffraction data KW - oxides KW - crystal chemistry KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51679101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+the+...+General+Meeting+of+the+International+Mineralogical+Association&rft.atitle=Neutron+and+temperature-resolved+synchrotron+X-ray+powder+diffraction+study+of+akaganeite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+P+J%3BVon+Dreele%2C+R+B%3BHanson%2C+J%3BParsons%2C+Ian&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2002-09-01&rft.volume=18&rft.issue=&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+the+...+General+Meeting+of+the+International+Mineralogical+Association&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 18th general meeting of the International Mineralogical Association N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - #03852 N1 - SubjectsTermNotLitGenreText - akaganeite; chlorine; crystal chemistry; crystal structure; experimental studies; halogens; hydrogen; laboratory studies; neutron diffraction data; order-disorder; oxides; powder method; refinement; Rietveld refinement; synchrotron radiation; temperature; unit cell; X-ray diffraction data ER - TY - JOUR T1 - Association of uranium with iron oxides typically formed on corroding steel surfaces. AN - 72067119; 12214641 AB - Decontamination of metal surfaces contaminated with low levels of radionuclides is a major concern at Department of Energy facilities. The development of an environmentally friendly and cost-effective decontamination process requires an understanding of their association with the corroding surfaces. We investigated the association of uranium with the amorphous and crystalline forms of iron oxides commonly formed on corroding steel surfaces. Uranium was incorporated with the oxide by addition during the formation of ferrihydrite, goethite, green rust II, lepidocrocite, maghemite, and magnetite. X-ray diffraction confirmed the mineralogical form of the oxide. EXAFS analysis at the U L(III) edge showed that uranium was present in hexavalent form as a uranyl oxyhydroxide species with goethite, maghemite, and magnetite and as a bidentate inner-sphere complex with ferrihydrite and lepidocrocite. Iron was present in the ferric form with ferrihydrite, goethite, lepidocrocite, and maghemite; whereas with magnetite and green rust II, both ferrous and ferric forms were present with characteristic ferrous:total iron ratios of 0.65 and 0.73, respectively. In the presence of the uranyl ion, green rust II was converted to magnetite with concomitantreduction of uranium to its tetravalent form. The rate and extent of uranium dissolution in dilute HCl depended on its association with the oxide: uranium present as oxyhydroxide species underwent rapid dissolution followed by a slow dissolution of iron; whereas uranium present as an inner-sphere complex with iron resulted in concomitant dissolution of the uranium and iron. JF - Environmental science & technology AU - Dodge, C J AU - Francis, A J AU - Gillow, J B AU - Halada, G P AU - Eng, C AU - Clayton, C R AD - Environmental Sciences Department, Brookhaven National Laboratory, Upton, New York 11973, USA. dodge1@bnl.gov Y1 - 2002/08/15/ PY - 2002 DA - 2002 Aug 15 SP - 3504 EP - 3511 VL - 36 IS - 16 SN - 0013-936X, 0013-936X KW - Ferric Compounds KW - 0 KW - Steel KW - 12597-69-2 KW - ferric oxide KW - 1K09F3G675 KW - Uranium KW - 4OC371KSTK KW - Index Medicus KW - Solubility KW - Corrosion KW - Environmental Pollution -- prevention & control KW - Steel -- chemistry KW - Ferric Compounds -- analysis KW - Ferric Compounds -- chemistry KW - Uranium -- chemistry KW - Uranium -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72067119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Association+of+uranium+with+iron+oxides+typically+formed+on+corroding+steel+surfaces.&rft.au=Dodge%2C+C+J%3BFrancis%2C+A+J%3BGillow%2C+J+B%3BHalada%2C+G+P%3BEng%2C+C%3BClayton%2C+C+R&rft.aulast=Dodge&rft.aufirst=C&rft.date=2002-08-15&rft.volume=36&rft.issue=16&rft.spage=3504&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-29 N1 - Date created - 2002-09-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - A Novel Mechanism for Clostridium botulinum Neurotoxin Inhibition AN - 18698909; 5594428 AB - Clostridium botulinum neurotoxins are zinc endopeptidase proteins responsible for cleaving specific peptide bonds of proteins of neuroexocytosis apparatus. The ability of drugs to interfere with toxin's catalytic activity is being evaluated with zinc chelators and metalloprotease inhibitors. It is important to develop effective pharmacological treatment for the intact holotoxin before the catalytic domain separates and enters the cytosol. We present here evidence for a novel mechanism of an inhibitor binding to the holotoxin and for the chelation of zinc from our structural studies on Clostridium botulinum neurotoxin type B in complex with a potential metalloprotease inhibitor, bis(5-amidino-2-benzimidazolyl)methane, and provide snapshots of the reaction as it progresses. The binding and inhibition mechanism of this inhibitor to the neurotoxin seems to be unique for intact botulinum neurotoxins. The environment of the active site rearranges in the presence of the inhibitor, and the zinc ion is gradually removed from the active site and transported to a different site in the protein, probably causing loss of catalytic activity. JF - Biochemistry (Washington) AU - Eswaramoorthy, S AU - Kumaran, D AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 2002/08/06/ PY - 2002 DA - 2002 Aug 06 SP - 9795 EP - 9802 VL - 41 IS - 31 SN - 0006-2960, 0006-2960 KW - bis(5-amidino-2-benzimidazolyl)methane KW - inhibition KW - peptide bonds KW - zinc endopeptidase KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - J 02822:Biosynthesis and physicochemical properties KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18698909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=A+Novel+Mechanism+for+Clostridium+botulinum+Neurotoxin+Inhibition&rft.au=Eswaramoorthy%2C+S%3BKumaran%2C+D%3BSwaminathan%2C+S&rft.aulast=Eswaramoorthy&rft.aufirst=S&rft.date=2002-08-06&rft.volume=41&rft.issue=31&rft.spage=9795&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi020060c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1021/bi020060c ER - TY - JOUR T1 - Biological effects of polychromatic light. AN - 72023448; 12194212 AB - Predicting the effects of polychromatic light on biological systems is a central goal of environmental photobiology. If the dose-response function for a process is a linear function of the light incident on a system at each wavelength within the spectrum, the effect of a polychromatic spectrum is obtained by integrating the product of the cross section for the reaction at each wavelength and the spectral irradiance at that wavelength over both wavelength and time. This procedure cannot be used, however, if the dose-response functions for an effect are not linear functions of photon dose. Although many photochemical reactions are linear within the biologically relevant range of doses, many biological end points are not. I describe procedures for calculating the effects of polychromatic irradiations on systems that exhibit certain classes of dose-response functions, including power law responses typical of mutation induction and exponential dose-responses typical of cell survival. I also present an approach to predict the effects of polychromatic spectra on systems in which the ultraviolet components form pyrimidine dimers, and the longer-wavelength ultraviolet and visible components remove them by photoreactivation, thus generating complex dose-response functions for these coupled light-driven reactions. JF - Photochemistry and photobiology AU - Sutherland, John C AD - Biology Department, Brookhaven National Laboratory, Upton, NY, USA. sutherlandj@mail.ecu.edu Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 164 EP - 170 VL - 76 IS - 2 SN - 0031-8655, 0031-8655 KW - Pyrimidine Dimers KW - 0 KW - Index Medicus KW - DNA Damage KW - Pyrimidine Dimers -- radiation effects KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Photobiology KW - Light UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72023448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Biological+effects+of+polychromatic+light.&rft.au=Sutherland%2C+John+C&rft.aulast=Sutherland&rft.aufirst=John&rft.date=2002-08-01&rft.volume=76&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-04 N1 - Date created - 2002-08-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Aerosols; the colloids of the atmosphere AN - 51868741; 2004-025576 JF - Geochimica et Cosmochimica Acta AU - Buseck, Peter R AU - Schwartz, Stephen E AU - Anonymous Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 111 PB - Pergamon, Oxford VL - 66 IS - 15A SN - 0016-7037, 0016-7037 KW - electron diffraction data KW - characterization KW - suspended materials KW - climate change KW - human ecology KW - sediments KW - ecology KW - spectra KW - particulate materials KW - nitrate ion KW - geochemistry KW - clouds KW - experimental studies KW - colloidal materials KW - sulfate ion KW - clastic sediments KW - human activity KW - atmosphere KW - X-ray spectra KW - TEM data KW - organic compounds KW - dust KW - solar radiation KW - sulfur KW - aerosols KW - public health KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51868741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Aerosols%3B+the+colloids+of+the+atmosphere&rft.au=Buseck%2C+Peter+R%3BSchwartz%2C+Stephen+E%3BAnonymous&rft.aulast=Buseck&rft.aufirst=Peter&rft.date=2002-08-01&rft.volume=66&rft.issue=15A&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 12th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - aerosols; atmosphere; characterization; clastic sediments; climate change; clouds; colloidal materials; dust; ecology; electron diffraction data; experimental studies; geochemistry; human activity; human ecology; nitrate ion; organic compounds; particulate materials; public health; sediments; solar radiation; spectra; sulfate ion; sulfur; suspended materials; TEM data; X-ray spectra ER - TY - JOUR T1 - Organic nitrogen in geomacromolecules: insights on speciation and transformation with K-edge XANES spectroscopy. AN - 71939869; 12141481 AB - Organic nitrogen incorporated into geomacromolecules (e.g., humic substances, kerogen) represents a major reservoir of nitrogen on the earth's surface, accounting for more than 90% of the total nitrogen in soils, sediments, and aquatic environments. Its primary source is biochemical nitrogen from dead plant and animal residues (predominantly proteinaceous substances), which undergo a complex series of transformations, mediated by microbes and abiotic processes, ultimately resulting in the incorporation of the nonmineralized fraction into geomacromolecules. Simultaneously,the biochemical N is thought to be extensively altered structurally, forming more stable structures (such as heterocyclic forms), although the type of changes in chemical speciation, their timing, and mechanisms are not clear. It is important to have this knowledge because the type of N formed influences not only its reactivity and fate (e.g., the release of bioavailable N in soils) but also the physical and chemical characteristics of the associated macromolecular organic matter. We used nitrogen K-edge XANES spectroscopy (a selective, sensitive, and nondestructive method) to gain new insights into the speciation of this macromolecular nitrogen. Our results verified amide N as being the dominant type in humic substances and sediments but revealed that pyridinic N also is a significant component of the total N (approximately 20-30%), with a subfraction consisting of its oxidized derivatives. An unidentified form of highly oxidized N was present mainly in sediments. While amide N represents residues of original biochemical molecules, pyridinic N probably is generated abiotically. Our results imply that the abiotic formation of pyridinic N sets in during the early stages of organic matter transformations thereby stabilizing organic N, although such processes generating heterocyclic structures may continue much longer. JF - Environmental science & technology AU - Vairavamurthy, A AU - Wang, S AD - Department of Energy Sciences and Technology, Brookhaven National Laboratory, Upton, New York 11973, USA. vmurthy@bnl.gov Y1 - 2002/07/15/ PY - 2002 DA - 2002 Jul 15 SP - 3050 EP - 3056 VL - 36 IS - 14 SN - 0013-936X, 0013-936X KW - Pyridines KW - 0 KW - Nitrogen KW - N762921K75 KW - Index Medicus KW - Environmental Monitoring KW - Spectrum Analysis KW - Biotransformation KW - Nitrogen -- chemistry KW - Geologic Sediments -- chemistry KW - Pyridines -- chemistry KW - Nitrogen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71939869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Organic+nitrogen+in+geomacromolecules%3A+insights+on+speciation+and+transformation+with+K-edge+XANES+spectroscopy.&rft.au=Vairavamurthy%2C+A%3BWang%2C+S&rft.aulast=Vairavamurthy&rft.aufirst=A&rft.date=2002-07-15&rft.volume=36&rft.issue=14&rft.spage=3050&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-08 N1 - Date created - 2002-07-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Bistranded Oxidized Purine Damage Clusters: Induced in DNA by Long-Wavelength Ultraviolet (290-400 nm) Radiation? AN - 18704343; 5594536 AB - Bistranded clustered DNA damages involving oxidized bases, abasic sites, and strand breaks are produced by ionizing radiation and radiomimetic drugs, but it was not known whether they can be formed by other agents, e.g., nonionizing radiation. UV radiation produces clusters of cyclobutyl pyrimidine dimers, photoproducts that occur individually in high yield. Since long-wavelength UV (290-400 nm) radiation induces oxidized bases, abasic sites, and strand breaks at low yields, we tested whether it also produces clusters containing these lesions. We exposed supercoiled pUC18 DNA to UV radiation with wavelengths of >290 nm (UVB plus UVA radiation), and assessed the induction of bistranded clustered oxidized purine and abasic clusters, as recognized by Escherichia coli Fpg protein and E. coli Nfo protein (endonuclease IV), respectively, as well as double-strand breaks. These three classes of bistranded clusters were detected, albeit at very low yields (37 Fpg-OxyPurine clusters Gbp super(-1) kJ super(-1) m super(2), 8.1 double-strand breaks Gbp super(-1) kJ super(-1) m super(2), and 3.4 Nfo-abasic clusters Gbp super(-1) kJ super(-1) m super(2)). Thus, these bistranded OxyPurine clusters, abasic clusters, and double-strand breaks are not uniquely induced by ionizing radiation and radiomimetic drugs, but their level of production by UVB and UVA radiation is negligible compared to the levels of frequent photoproducts such as pyrimidine dimers. JF - Biochemistry (Washington) AU - Song, J M AU - Milligan, J R AU - Sutherland, B M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA Y1 - 2002/07/09/ PY - 2002 DA - 2002 Jul 09 SP - 8683 EP - 8688 VL - 41 IS - 27 SN - 0006-2960, 0006-2960 KW - Fpg protein KW - Nfo protein KW - purines KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18704343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Bistranded+Oxidized+Purine+Damage+Clusters%3A+Induced+in+DNA+by+Long-Wavelength+Ultraviolet+%28290-400+nm%29+Radiation%3F&rft.au=Song%2C+J+M%3BMilligan%2C+J+R%3BSutherland%2C+B+M&rft.aulast=Song&rft.aufirst=J&rft.date=2002-07-09&rft.volume=41&rft.issue=27&rft.spage=8683&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi020137x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1021/bi020137x ER - TY - JOUR T1 - Effect of vehicle on brain uptake of [11C]toluene. AN - 71866020; 12088732 AB - With the goal of investigating the pharmacokinetics of the abused solvent, toluene we have adapted the rapid coupling of methyl iodide with tributylphenylstannane mediated by palladium(0) complex to the synthesis of no-carrier-added [11C]toluene starting with 11CH(3)I. Two methods for purification and formulation of the tracer were developed. The first one yielded [11C]toluene dissolved in dimethylacetamide/saline solution, for the second one we adapted supercritical fluid technology where the tracer was purified using and conventional C(18) HPLC column and pure supercritical CO(2) fluid as a mobile phase operating at 2000 psi. Formulation of the tracer in cyclodextrin resulted in a significantly higher integrated uptake and distribution volume values. Additionally, we observed higher uptake and slower clearance of 11C-toluene in white matter, consistent with higher lipid content and neurotoxicological evidence indicating restricted and diffuse white matter changes in toluene abusers. This trend was observed when either DMA or cyclodextrin was used as a vehicle. It appears then, that the choice of a vehicle affected only the degree of bioavailability, but not the regional brain pharmacokinetics. Finally, we demonstrated the effect of a decreased percent difference between DV values for the studies performed on the same day, that is, test/retest variability was lower for all brain regions in beta-cyclodextrin experiments. Present results clearly demonstrate that the choice of a vehicle has a significant effect on tracer uptake and should be considered as a potential factor contributing to the pharmacokinetic measurements. JF - Nuclear medicine and biology AU - Gerasimov, Madina R AU - Logan, Jean AU - Ferrieri, Richard A AU - Muller, Ryan D AU - Alexoff, David AU - Dewey, Stephen L AD - Brookhaven National Laboratory, Department of Chemistry, Upton, NY 11973, USA. madina@bnl.gov Y1 - 2002/07// PY - 2002 DA - July 2002 SP - 607 EP - 612 VL - 29 IS - 5 SN - 0969-8051, 0969-8051 KW - Acetamides KW - 0 KW - Carbon Radioisotopes KW - Cyclodextrins KW - Pharmaceutical Vehicles KW - Radiopharmaceuticals KW - Toluene KW - 3FPU23BG52 KW - dimethylacetamide KW - JCV5VDB3HY KW - Index Medicus KW - Pharmaceutical Vehicles -- pharmacology KW - Papio KW - Radiopharmaceuticals -- pharmacokinetics KW - Animals KW - Acetamides -- pharmacology KW - Radiopharmaceuticals -- chemical synthesis KW - Tissue Distribution KW - Female KW - Radionuclide Imaging KW - Carbon Radioisotopes -- pharmacokinetics KW - Cyclodextrins -- pharmacology KW - Toluene -- pharmacokinetics KW - Isotope Labeling -- methods KW - Brain -- metabolism KW - Carbon Radioisotopes -- isolation & purification KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71866020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+medicine+and+biology&rft.atitle=Effect+of+vehicle+on+brain+uptake+of+%5B11C%5Dtoluene.&rft.au=Gerasimov%2C+Madina+R%3BLogan%2C+Jean%3BFerrieri%2C+Richard+A%3BMuller%2C+Ryan+D%3BAlexoff%2C+David%3BDewey%2C+Stephen+L&rft.aulast=Gerasimov&rft.aufirst=Madina&rft.date=2002-07-01&rft.volume=29&rft.issue=5&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Nuclear+medicine+and+biology&rft.issn=09698051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-10 N1 - Date created - 2002-06-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users. AN - 71752553; 12036507 AB - This study aims to determine possible persistent abnormalities in regional cerebral blood flow (relative rCBF) and cognitive function in abstinent methamphetamine (METH) users. Twenty METH-dependent subjects (abstinent for 8+/-2 months) and 20 age- and gender-matched controls were evaluated with perfusion magnetic resonance imaging (pMRI) and neuropsychological tests. METH users showed decreased relative rCBF bilaterally in putamen/insular cortices (right: -12%; left: -10%) and the right lateral parietal brain region (-11%), but increased relative rCBF bilaterally in the left temporoparietal white matter (+13%), the left occipital brain region: (+10%) and the right posterior parietal region (+24%). Interaction effects were observed between METH and gender in the right occipital cortex and a midline brain region; female METH users showed increased relative rCBF (+15% both regions) whereas the male METH users had decreased relative rCBF (-10% and -18%, respectively). METH users performed within normal ranges on standard neuropsychological tests; however, they were slower on several tasks on the California Computerized Assessment Package (CalCAP), especially tasks that required working memory. These findings suggest that METH abuse is associated with persistent physiologic changes in the brain, and these changes are accompanied by slower reaction times on computerized measures of cognitive function. JF - Psychiatry research AU - Chang, Linda AU - Ernst, Thomas AU - Speck, Oliver AU - Patel, Hetal AU - DeSilva, Menaka AU - Leonido-Yee, Maria AU - Miller, Eric N AD - Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY, 11973-5000, USA. changl@bnl.gov Y1 - 2002/06/15/ PY - 2002 DA - 2002 Jun 15 SP - 65 EP - 79 VL - 114 IS - 2 SN - 0165-1781, 0165-1781 KW - Contrast Media KW - 0 KW - Heterocyclic Compounds KW - Organometallic Compounds KW - gadoteridol KW - 0199MV609F KW - Methamphetamine KW - 44RAL3456C KW - Gadolinium KW - AU0V1LM3JT KW - Index Medicus KW - Reaction Time -- drug effects KW - Reference Values KW - Humans KW - Adult KW - Regional Blood Flow -- drug effects KW - Image Enhancement KW - Male KW - Female KW - Substance-Related Disorders -- physiopathology KW - Echo-Planar Imaging KW - Substance-Related Disorders -- diagnosis KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance Withdrawal Syndrome -- diagnosis KW - Methamphetamine -- adverse effects KW - Brain -- drug effects KW - Brain -- blood supply KW - Diagnosis, Computer-Assisted KW - Substance Withdrawal Syndrome -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Neuropsychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71752553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Perfusion+MRI+and+computerized+cognitive+test+abnormalities+in+abstinent+methamphetamine+users.&rft.au=Chang%2C+Linda%3BErnst%2C+Thomas%3BSpeck%2C+Oliver%3BPatel%2C+Hetal%3BDeSilva%2C+Menaka%3BLeonido-Yee%2C+Maria%3BMiller%2C+Eric+N&rft.aulast=Chang&rft.aufirst=Linda&rft.date=2002-06-15&rft.volume=114&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-31 N1 - Date created - 2002-05-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Clustered DNA damages induced by x rays in human cells. AN - 71690707; 12005538 AB - Although DNA DSBs are known to be important in producing the damaging effects of ionizing radiation in cells, bistranded clustered DNA damages-two or more oxidized bases, abasic sites or strand breaks on opposing DNA strands within a few helical turns-are postulated to be difficult to repair and thus to be critical radiation-induced lesions. Gamma rays can induce clustered damages in DNA in solution, and high-energy iron ions produce DSBs and oxidized pyrimidine clusters in human cells, but it was not known whether sparsely ionizing radiation can produce clustered damages in mammalian cells. We show here that X rays induce abasic clusters, oxidized pyrimidine clusters, and oxidized purine clusters in DNA in human cells. Non-DSB clustered damages comprise about 70% of the complex lesions produced in cells. The relative levels of specific cluster classes depend on the environment of the DNA. JF - Radiation research AU - Sutherland, Betsy M AU - Bennett, Paula V AU - Sutherland, John C AU - Laval, Jacques AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. bms@bnl.gov Y1 - 2002/06// PY - 2002 DA - June 2002 SP - 611 EP - 616 VL - 157 IS - 6 SN - 0033-7587, 0033-7587 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - Non-programmatic KW - X-Rays KW - Humans KW - Electrophoresis, Agar Gel KW - Dose-Response Relationship, Radiation KW - Molecular Weight KW - Cell Line KW - DNA -- metabolism KW - DNA -- genetics KW - DNA Damage -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71690707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Clustered+DNA+damages+induced+by+x+rays+in+human+cells.&rft.au=Sutherland%2C+Betsy+M%3BBennett%2C+Paula+V%3BSutherland%2C+John+C%3BLaval%2C+Jacques&rft.aulast=Sutherland&rft.aufirst=Betsy&rft.date=2002-06-01&rft.volume=157&rft.issue=6&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-19 N1 - Date created - 2002-05-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cesium adsorption on clay minerals; an EXAFS spectroscopic investigation AN - 51839199; 2004-044989 JF - Environmental Science & Technology, ES & T AU - Bostick, Benjamin C AU - Vairavamurthy, Murthy A AU - Karthikeyan, K G AU - Chorover, Jon Y1 - 2002/06// PY - 2002 DA - June 2002 SP - 2670 EP - 2676 PB - American Chemical Society, Washington, DC VL - 36 IS - 12 SN - 0013-936X, 0013-936X KW - silicates KW - isotopes KW - complexing KW - ground water KW - laboratory studies KW - radioactive isotopes KW - cesium KW - sediments KW - X-ray analysis KW - montmorillonite KW - soils KW - toxic materials KW - experimental studies KW - monitoring KW - underground storage KW - alkali metals KW - pollution KW - migration of elements KW - kaolinite KW - adsorption KW - clay minerals KW - Cs-137 KW - metals KW - X-ray spectroscopy KW - underground installations KW - sheet silicates KW - vermiculite KW - spectroscopy KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51839199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Cesium+adsorption+on+clay+minerals%3B+an+EXAFS+spectroscopic+investigation&rft.au=Bostick%2C+Benjamin+C%3BVairavamurthy%2C+Murthy+A%3BKarthikeyan%2C+K+G%3BChorover%2C+Jon&rft.aulast=Bostick&rft.aufirst=Benjamin&rft.date=2002-06-01&rft.volume=36&rft.issue=12&rft.spage=2670&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/ L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 39 N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - adsorption; alkali metals; cesium; clay minerals; complexing; Cs-137; experimental studies; ground water; isotopes; kaolinite; laboratory studies; metals; migration of elements; monitoring; montmorillonite; pollution; radioactive isotopes; sediments; sheet silicates; silicates; soils; spectroscopy; toxic materials; underground installations; underground storage; vermiculite; X-ray analysis; X-ray spectroscopy ER - TY - JOUR T1 - Plant and Environment Interactions: Uptake of Cesium-137 and Strontium-90 from Contaminated Soil by Three Plant Species; Application to Phytoremediation AN - 20983562; 5411170 AB - A field test was conducted to determine the ability of three plant species to extract super(137)Cs and super(90)Sr from contaminated soil. Redroot pigweed (Amaranthus retroflexus L.), Indian mustard [Brassica juncea (L.) Czern.], and tepary bean (Phaseolus acutifolius A. Gray) were planted in a series of spatially randomized cells in soil that was contaminated in the 1950s and 1960s. We examined the potential for phytoextraction of super(90)Sr and super(137)Cs by these three species. Concentration ratios (CR) for super(137)Cs for redroot pigweed, Indian mustard, and tepary bean were 2.58, 0.46, and 0.17, respectively. For super(90)Sr they were substantially higher: 6.5, 8.2, and 15.2, respectively. The greatest accumulation of both radionuclides was obtained with redroot pigweed, even though its CR for super(90)Sr was the lowest, because of its relatively large biomass. There was a linear relationship between the super(137)Cs concentration in plants and its concentration in soil only for redroot pigweed. Uptake of super(90)Sr exhibits no relationship to super(90)Sr concentrations in the soil. Estimates of time required for removal of 50% of the two contaminants, assuming two crops of redroot pigweed per year, are 7 yr for super(90)Sr and 18 yr for super(137)Cs. JF - Journal of Environmental Quality AU - Fuhrmann, M AU - Lasat, M M AU - Ebbs, S D AU - Kochian, LV AU - Cornish, J AD - Environmental and Waste Technology Group, Brookhaven National Lab., Building 830, Upton, NY 11973-5000, USA, fuhrmann@bnl.gov Y1 - 2002/06// PY - 2002 DA - Jun 2002 SP - 904 EP - 909 VL - 31 IS - 3 SN - 0047-2425, 0047-2425 KW - Tepiary bean KW - Biotechnology and Bioengineering Abstracts; Pollution Abstracts KW - Cesium KW - Amaranthus retroflexus KW - Soil contamination KW - Biomass KW - Beans KW - Crops KW - Phaseolus acutifolius KW - Brassica juncea KW - Soil pollution KW - Soil KW - Phytoremediation KW - Plants KW - Radioisotopes KW - Environmental quality KW - Strontium KW - Plant extracts KW - Contaminants KW - phytoremediation KW - W 30950:Waste Treatment & Pollution Clean-up KW - P 8000:RADIATION KW - P 5000:LAND POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20983562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Quality&rft.atitle=Plant+and+Environment+Interactions%3A+Uptake+of+Cesium-137+and+Strontium-90+from+Contaminated+Soil+by+Three+Plant+Species%3B+Application+to+Phytoremediation&rft.au=Fuhrmann%2C+M%3BLasat%2C+M+M%3BEbbs%2C+S+D%3BKochian%2C+LV%3BCornish%2C+J&rft.aulast=Fuhrmann&rft.aufirst=M&rft.date=2002-06-01&rft.volume=31&rft.issue=3&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-10-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Soil; Soil pollution; Radioisotopes; Environmental quality; Strontium; Plant extracts; Biomass; phytoremediation; Contaminants; Crops; Beans; Cesium; Phytoremediation; Plants; Soil contamination; Brassica juncea; Amaranthus retroflexus; Phaseolus acutifolius ER - TY - JOUR T1 - Uptake of cesium-137 and strontium-90 from contaminated soil by three plant species; application to phytoremediation. AN - 71706776; 12026094 AB - A field test was conducted to determine the ability of three plant species to extract 137Cs and 90Sr from contaminated soil. Redroot pigweed (Amaranthus retroflexus L.), Indian mustard [Brassica juncea (L.) Czern.], and tepary bean (Phaseolus acutifolius A. Gray) were planted in a series of spatially randomized cells in soil that was contaminated in the 1950s and 1960s. We examined the potential for phytoextraction of 90Sr and 137Cs by these three species. Concentration ratios (CR) for 137Cs for redroot pigweed, Indian mustard, and tepary bean were 2.58, 0.46, and 0.17, respectively. For 90Sr they were substantially higher: 6.5, 8.2, and 15.2, respectively. The greatest accumulation of both radionuclides was obtained with redroot pigweed, even though its CR for 90Sr was the lowest, because of its relatively large biomass. There was a linear relationship between the 137Cs concentration in plants and its concentration in soil only for redroot pigweed. Uptake of 90Sr exhibits no relationship to 90Sr concentrations in the soil. Estimates of time required for removal of 50% of the two contaminants, assuming two crops of redroot pigweed per year, are 7 yr for 90Sr and 18 yr for 137Cs. JF - Journal of environmental quality AU - Fuhrmann, Mark AU - Lasat, Mitch M AU - Ebbs, Stephen D AU - Kochian, Leon V AU - Cornish, Jay AD - Environmental and Waste Technology Group, Brookhaven National Lab., Upton, NY 11973-5000, USA. fuhrmann@bnl.gov PY - 2002 SP - 904 EP - 909 VL - 31 IS - 3 SN - 0047-2425, 0047-2425 KW - Cesium Radioisotopes KW - 0 KW - Soil Pollutants, Radioactive KW - Strontium Radioisotopes KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Amaranthus -- metabolism KW - Phaseolus -- metabolism KW - Brassica -- metabolism KW - Conservation of Natural Resources KW - Soil Pollutants, Radioactive -- pharmacology KW - Strontium Radioisotopes -- pharmacology KW - Cesium Radioisotopes -- pharmacology KW - Soil Pollutants, Radioactive -- administration & dosage KW - Cesium Radioisotopes -- administration & dosage KW - Strontium Radioisotopes -- administration & dosage KW - Angiosperms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71706776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+quality&rft.atitle=Uptake+of+cesium-137+and+strontium-90+from+contaminated+soil+by+three+plant+species%3B+application+to+phytoremediation.&rft.au=Fuhrmann%2C+Mark%3BLasat%2C+Mitch+M%3BEbbs%2C+Stephen+D%3BKochian%2C+Leon+V%3BCornish%2C+Jay&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2002-05-01&rft.volume=31&rft.issue=3&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-07 N1 - Date created - 2002-05-23 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Size effect of hematite and corundum inclusions on the efflorescence relative humidities of aqueous ammonium nitrate particles AN - 52024965; 2003-010572 JF - Journal of Geophysical Research AU - Han, Jeong-Ho AU - Hung, Hui-Ming AU - Martin, Scot T Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 10 PB - American Geophysical Union, Washington, DC VL - 107 IS - D9-10 SN - 0148-0227, 0148-0227 KW - silicates KW - sorption KW - aqueous solutions KW - corundum KW - infrared spectra KW - chemical reactions KW - hematite KW - sediments KW - orthosilicates KW - mullite KW - oxides KW - spectra KW - ammonium nitrate KW - clastic sediments KW - grain size KW - nitrates KW - atmosphere KW - nesosilicates KW - humidity KW - efflorescence KW - saturation KW - dust KW - aerosols KW - particles KW - minerals KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52024965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Size+effect+of+hematite+and+corundum+inclusions+on+the+efflorescence+relative+humidities+of+aqueous+ammonium+nitrate+particles&rft.au=Han%2C+Jeong-Ho%3BHung%2C+Hui-Ming%3BMartin%2C+Scot+T&rft.aulast=Han&rft.aufirst=Jeong-Ho&rft.date=2002-05-01&rft.volume=107&rft.issue=D9-10&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2001JD001054 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 39 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aerosols; ammonium nitrate; aqueous solutions; atmosphere; chemical reactions; clastic sediments; corundum; dust; efflorescence; grain size; hematite; humidity; infrared spectra; minerals; mullite; nesosilicates; nitrates; orthosilicates; oxides; particles; saturation; sediments; silicates; sorption; spectra DO - http://dx.doi.org/10.1029/2001JD001054 ER - TY - JOUR T1 - Photodegradation of a Ternary Iron(III)-Uranium(VI)-Citric Acid Complex AN - 16142661; 5467642 AB - The mechanisms of photodegradation of binary iron- and uranium-citrate and ternary iron-uranium-citrate complexes were elucidated. Citric acid degradation products were identified by HPLC and GC, and the metal precipitates were identified by XRD and EXAFS. Photodegradation of a binuclear iron-citrate complex occurred as a result of two one-electron oxidations of citric acid with the formation of 3-oxoglutarate and two ferrous ions. The ferrous ions were reoxidized by a photo-Fenton reaction, resulting in the precipitation of iron as two-line ferrihydrite Fe(OH) sub(3). The citric acid in the uranium-citrate complex underwent a two-electron oxidation to acetoacetate with the concomitant reduction of U(VI) to U(IV). The U(IV) was subsequently photooxidized in the presence of dioxygen with precipitation of uranium as the mineral schoepite (UO sub(3) times 2H sub(2)O). A two-step electron reduction of two ferric ions to two ferrous ions was the primary mechanism for photodegradation of the ternary iron-uranium-citrate complex with oxidation of citric acid to 3-oxoglutarate; reduction of uranium was not observed. The iron precipitated as ferrihydrite and the uranyl ion as a uranyl hydroxide species. These results show the potential application of photochemical treatment of wastewater and decontamination solutions containing binary and ternary iron- and uranium-citrate complexes. JF - Environmental Science & Technology AU - Dodge, C J AU - Francis, A J AD - Environmental Sciences Department, Brookhaven National Laboratory, Upton, NY 11973, USA, dodge1@bnl.gov Y1 - 2002/05/01/ PY - 2002 DA - 2002 May 01 SP - 2094 EP - 2100 VL - 36 IS - 9 SN - 0013-936X, 0013-936X KW - citric acid KW - Pollution Abstracts KW - Photochemistry KW - Photodegradation KW - Uranium KW - Oxidation KW - Iron KW - Wastewater treatment KW - P 3000:SEWAGE & WASTEWATER TREATMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16142661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Photodegradation+of+a+Ternary+Iron%28III%29-Uranium%28VI%29-Citric+Acid+Complex&rft.au=Dodge%2C+C+J%3BFrancis%2C+A+J&rft.aulast=Dodge&rft.aufirst=C&rft.date=2002-05-01&rft.volume=36&rft.issue=9&rft.spage=2094&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Photochemistry; Photodegradation; Uranium; Oxidation; Wastewater treatment; Iron ER - TY - JOUR T1 - Shedding light on proteins, nucleic acids, cells, humans and fish. AN - 71532864; 11906839 AB - I was trained as a physicist in graduate school. Hence, when I decided to go into the field of biophysics, it was natural that I concentrated on the effects of light on relatively simple biological systems, such as proteins. The wavelengths absorbed by the amino acid subunits of proteins are in the ultraviolet (UV). The wavelengths that affect the biological activities, the action spectra, also are in the UV, but are not necessarily parallel to the absorption spectra. Understanding these differences led me to investigate the action spectra for affecting nucleic acids, and the effects of UV on viruses and cells. The latter studies led me to the discovery of the important molecular nature of the damages affecting DNA (cyclobutane pyrimidine dimers) and to the discovery of nucleotide excision repair. Individuals with the genetic disease xeroderma pigmentosum (XP) are extraordinarily sensitive to sunlight-induced skin cancer. The finding, by James Cleaver, that their skin cells were defective in DNA repair strongly suggested that DNA damage was a key step in carcinogenesis. Such information was important for estimating the wavelengths in sunlight responsible for human skin cancer and for predicting the effects of ozone depletion on the incidence of non-melanoma skin cancer. It took experiments with backcross hybrid fish to call attention to the probable role of the longer UV wavelengths not absorbed by DNA in the induction of melanoma. These reflections trace the biophysicist's path from molecules to melanoma. JF - Mutation research AU - Setlow, Richard B AD - Biology Department, Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA. setlow@bnl.gov Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 1 EP - 14 VL - 511 IS - 1 SN - 0027-5107, 0027-5107 KW - PrPSc Proteins KW - 0 KW - Proteins KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - Setlow KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - United States KW - Animals KW - History, 20th Century KW - PrPSc Proteins -- radiation effects KW - Melanoma -- history KW - Melanoma -- etiology KW - Humans KW - Fishes KW - Cells, Cultured -- radiation effects KW - Xeroderma Pigmentosum -- genetics KW - Poecilia -- physiology KW - Xeroderma Pigmentosum -- history KW - Ultraviolet Rays -- history KW - Proteins -- history KW - DNA -- radiation effects KW - Proteins -- radiation effects KW - DNA -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71532864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Shedding+light+on+proteins%2C+nucleic+acids%2C+cells%2C+humans+and+fish.&rft.au=Setlow%2C+Richard+B&rft.aulast=Setlow&rft.aufirst=Richard&rft.date=2002-03-01&rft.volume=511&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-19 N1 - Date created - 2002-03-21 N1 - Date revised - 2017-02-17 N1 - People - Setlow N1 - Last updated - 2017-02-22 N1 - SubjectsTermNotLitGenreText - Setlow ER - TY - JOUR T1 - Jolly SAD. AN - 71466174; 11856836 AB - Examples of phasing macromolecular crystal structures based on single-wavelength anomalous dispersion (SAD) show that this approach is more powerful and may have more general application in structural biology than was anticipated. Better data-collection facilities and cryogenic techniques, coupled with powerful programs for data processing, phasing, density modification and automatic model building, means that the SAD approach may gain wide popularity owing to its simplicity, less stringent wavelength requirements and faster data collection and phasing than the multi-wavelength (MAD) approach. It can be performed at any wavelength where anomalous scattering can be observed, in many cases using laboratory X-ray sources. JF - Acta crystallographica. Section D, Biological crystallography AU - Dauter, Zbigniew AU - Dauter, Miroslawa AU - Dodson, Eleanor AD - Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, NCI, Brookhaven National Laboratory, Building 725A-X9, Upton, NY 11973, USA. dauter@bnl.gov Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 494 EP - 506 VL - 58 SN - 0907-4449, 0907-4449 KW - Ferredoxins KW - 0 KW - Insulin KW - Lithium Compounds KW - Metals, Heavy KW - Oligopeptides KW - Rubredoxins KW - Sulfates KW - Phosphorus KW - 27YLU75U4W KW - Manganese KW - 42Z2K6ZL8P KW - Chlorine KW - 4R7X1O2820 KW - Sulfur KW - 70FD1KFU70 KW - DNA KW - 9007-49-2 KW - lithium sulfate KW - 919XA137JK KW - Selenomethionine KW - 964MRK2PEL KW - Iron KW - E1UOL152H7 KW - Thiolester Hydrolases KW - EC 3.1.2.- KW - Muramidase KW - EC 3.2.1.17 KW - Carboxypeptidases KW - EC 3.4.- KW - serine carboxypeptidase KW - EC 3.4.16.5 KW - Subtilisin KW - EC 3.4.21.62 KW - Pyrophosphatases KW - EC 3.6.1.- KW - dUTP pyrophosphatase KW - EC 3.6.1.23 KW - Aldose-Ketose Isomerases KW - EC 5.3.1.- KW - xylose isomerase KW - EC 5.3.1.5 KW - Zinc KW - J41CSQ7QDS KW - Bromine KW - SBV4XY874G KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium -- chemistry KW - Oligopeptides -- chemistry KW - Sulfur -- chemistry KW - Zinc -- chemistry KW - Molecular Weight KW - Phosphorus -- chemistry KW - Bromine -- chemistry KW - Carboxypeptidases -- chemistry KW - DNA -- chemistry KW - Protein Conformation KW - Pyrophosphatases -- chemistry KW - Selenomethionine -- chemistry KW - Aldose-Ketose Isomerases -- chemistry KW - Models, Molecular KW - Subtilisin -- chemistry KW - Lithium Compounds -- chemistry KW - Iron -- chemistry KW - Insulin -- chemistry KW - Ferredoxins -- chemistry KW - Sulfates -- chemistry KW - Muramidase -- chemistry KW - Thiolester Hydrolases -- chemistry KW - Manganese -- chemistry KW - Rubredoxins -- chemistry KW - Chlorine -- chemistry KW - Models, Chemical KW - Metals, Heavy -- chemistry KW - Crystallography, X-Ray -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71466174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.atitle=Jolly+SAD.&rft.au=Dauter%2C+Zbigniew%3BDauter%2C+Miroslawa%3BDodson%2C+Eleanor&rft.aulast=Dauter&rft.aufirst=Zbigniew&rft.date=2002-03-01&rft.volume=58&rft.issue=&rft.spage=494&rft.isbn=&rft.btitle=&rft.title=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.issn=09074449&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-18 N1 - Date created - 2002-03-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Monoclinic nearly stoichiometric wustite at low temperatures AN - 51875565; 2004-020573 AB - The crystallographic and magnetic structures of Fe (sub 0.99) O at 10 K have been determined by high-resolution neutron powder diffraction. Fe (sub 0.99) O is found to be monoclinic, space group C2/m, with unit-cell dimensions a = 5.2615(1), b = 3.0334(1), c = 3.0602 (1) Aa, and beta = 124.649(2) degrees . The Fe-O distances in the distorted FeO (sub 6) octahedron are 2.154 AaX4 and 2.165 AaX2. The magnetic unit cell is obtained by doubling one of the crystallographic axes, a (magn) = a (sub m) , b (magn) = b (sub m) , and c (magn) = 2c (sub m) . The refined magnetic components at 8 K are M (sub x) = 2.7(1) mu B, M (sub y) = -0.9(2) mu B, and M (sub z) = 4.77(2)mu B, with resultant M = 4.03(2) mu B. JF - American Mineralogist AU - Fjellvag, Helmer AU - Hauback, Bjorn C AU - Vogt, Tom AU - Stolen, Svein Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 347 EP - 349 PB - Mineralogical Society of America, Washington, DC VL - 87 IS - 2-3 SN - 0003-004X, 0003-004X KW - crystal systems KW - low temperature KW - unit cell KW - oxides KW - monoclinic system KW - crystallography KW - wustite KW - stoichiometry KW - temperature KW - order-disorder KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51875565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Monoclinic+nearly+stoichiometric+wustite+at+low+temperatures&rft.au=Fjellvag%2C+Helmer%3BHauback%2C+Bjorn+C%3BVogt%2C+Tom%3BStolen%2C+Svein&rft.aulast=Fjellvag&rft.aufirst=Helmer&rft.date=2002-03-01&rft.volume=87&rft.issue=2-3&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 17 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - crystal systems; crystallography; low temperature; monoclinic system; order-disorder; oxides; stoichiometry; temperature; unit cell; wustite ER - TY - JOUR T1 - Toluene inhalation produces regionally specific changes in extracellular dopamine. AN - 71456049; 11841896 AB - The aim of the present study was to investigate the effect of toluene inhalation on dopaminergic transmission in two distinct brain areas presumably involved in mediating the reward processes important for toluene abuse. Extracellular dopamine (DA) levels were measured in prefrontal cortex (PFC) and nucleus accumbens (NACC) of freely moving rats using in vivo microdialysis. Inhalation of a behaviorally relevant concentration of toluene (3000 ppm) produced a significant increase in the PFC but not in the NACC. However, the odorant isoamyl acetate, increased PFC DA levels by only 37%, significantly less than the 96% increase observed following toluene exposure. When toluene inhalation was combined with cocaine administration (20 mg/kg i.p.), the response to the combined challenge was not different from the response to toluene alone in the PFC. However, the combination of these two drugs produced a supradditive response of 802% in the NACC, compared with the 450% increase observed following cocaine alone. Recent reports indicate that toluene influences the function of several ionotropic receptors in a subunit specific manner. As further evidence of specific effects, our results indicate regionally specific changes in dopaminergic transmission following toluene exposure. JF - Drug and alcohol dependence AU - Gerasimov, Madina R AU - Schiffer, Wynne K AU - Marstellar, Douglas AU - Ferrieri, Richard AU - Alexoff, David AU - Dewey, Stephen L AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. madina@bnl.gov Y1 - 2002/02/01/ PY - 2002 DA - 2002 Feb 01 SP - 243 EP - 251 VL - 65 IS - 3 SN - 0376-8716, 0376-8716 KW - Dopamine Uptake Inhibitors KW - 0 KW - Pentanols KW - Toluene KW - 3FPU23BG52 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - isoamyl acetate KW - Z135787824 KW - Index Medicus KW - Rats KW - Pentanols -- pharmacology KW - Microdialysis KW - Animals KW - Rats, Sprague-Dawley KW - Drug Synergism KW - Cocaine -- pharmacology KW - Administration, Inhalation KW - Dopamine Uptake Inhibitors -- pharmacology KW - Toluene -- pharmacology KW - Prefrontal Cortex -- metabolism KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- metabolism KW - Dopamine -- metabolism KW - Prefrontal Cortex -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71456049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Toluene+inhalation+produces+regionally+specific+changes+in+extracellular+dopamine.&rft.au=Gerasimov%2C+Madina+R%3BSchiffer%2C+Wynne+K%3BMarstellar%2C+Douglas%3BFerrieri%2C+Richard%3BAlexoff%2C+David%3BDewey%2C+Stephen+L&rft.aulast=Gerasimov&rft.aufirst=Madina&rft.date=2002-02-01&rft.volume=65&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-23 N1 - Date created - 2002-02-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Reactive oxygen species in cell responses to toxic agents AN - 18446406; 5419095 AB - This review first summarizes experimental data on biological effects of different concentrations of ROS in mammalian cells and on their potential role in modifying cell responses to toxic agents. It then attempts to link the role of steadily produced metabolic ROS at various concentrations in mammalian cells to that of environmentally derived ROS bursts from exposure to ionizing radiation. The ROS from both sources are known to both cause biological damage and change cellular signaling, depending on their concentration at a given time. At low concentrations signaling effects of ROS appear to protect cellular survival and dominate over damage, and the reverse occurs at high ROS concentrations. Background radiation generates suprabasal ROS bursts along charged particle tracks several times a year in each nanogram of tissue, i.e., average mass of a mammalian cell. For instance, a burst of about 200 ROS occurs within less than a microsecond from low-LET irradiation such as X-rays along the track of a Compton electron (about 6 keV, ranging about 1 mu m). One such track per nanogram tissue gives about 1 mGy to this mass. The number of instantaneous ROS per burst along the track of a 4-meV alpha -particle in 1 ng tissue reaches some 70 000. The sizes, types and sites of these bursts, and the time intervals between them directly in and around cells appear essential for understanding low-dose and low dose-rate effects on top of effects from endogenous ROS. At background and low-dose radiation exposure, a major role of ROS bursts along particle tracks focuses on ROS-induced apoptosis of damage-carrying cells, and also on prevention and removal of DNA damage from endogenous sources by way of temporarily protective, i.e., adaptive, cellular responses. A conclusion is to consider low-dose radiation exposure as a provider of physiological mechanisms for tissue homoeostasis. JF - Human & Experimental Toxicology AU - Feinendegen, LE AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11073, USA, feinendegen@gmx.net Y1 - 2002/02// PY - 2002 DA - Feb 2002 SP - 85 EP - 90 VL - 21 IS - 2 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18446406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Reactive+oxygen+species+in+cell+responses+to+toxic+agents&rft.au=Feinendegen%2C+LE&rft.aulast=Feinendegen&rft.aufirst=LE&rft.date=2002-02-01&rft.volume=21&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Retrieval of aerosol properties from moments of the particle size distribution for kernels involving the step function: Cloud droplet activation AN - 18293315; 5347211 AB - Aerosol properties such as the number of particles that activate to form cloud drops and the mass contained within specified size ranges (as in the PM 2.5 and PM 10 regulatory standards) require integration over only part of the full size range of the particle distribution function (PDF) and may be formally expressed as integrals over kernels involving the Heaviside step function. Determination of these properties requires essentially that the size spectrum be partitioned into two (or more) portions, and poses a special challenge for aerosol modeling with the method of moments. To assess the ability of moment-based methods to treat kernels involving step functions, several algorithms for the estimation of aerosol properties associated with cloud activation have been evaluated. For 240 measured continental distributions employed here as test cases, the full size spectrum of the PDF was partitioned into three distinct portions based upon characteristic critical radii for activation in cumulus and stratiform clouds, and mass- and number-concentration metrics were evaluated for each portion. The first six radial moments yielded results accurate to within about 10% or better, on average, and the numbers of particles activated as cloud drops and the aerosol mass taken into cloud water were estimated to an accuracy of 5% or better. Of the moment-based approaches evaluated, the multiple isomomental distribution aerosol surrogate (MIDAS) (Wright, J. Aerosol Sci. 31 (2000) 1) technique performed best. Accurate results were also obtained with the randomized minimization search technique (RMST) (Yue et al., Geophys. Res. Lett. 24 (1997) 651; Heintzenberg et al., Appl. Opt. 20 (1981) 1308). JF - Journal of Aerosol Science AU - Wright, D L AU - Yu, Sh AU - Kasibhatla, P S AU - McGraw, R AU - Schwartz, SE AU - Saxena, V K AU - Yue, G K AD - Nicholas School of the Environment, Duke University, Durham, NC 27708, USA, dlw@bnl.gov Y1 - 2002/02// PY - 2002 DA - Feb 2002 SP - 319 EP - 337 VL - 33 IS - 2 SN - 0021-8502, 0021-8502 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Particle size KW - Aerosols KW - A 01118:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18293315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aerosol+Science&rft.atitle=Retrieval+of+aerosol+properties+from+moments+of+the+particle+size+distribution+for+kernels+involving+the+step+function%3A+Cloud+droplet+activation&rft.au=Wright%2C+D+L%3BYu%2C+Sh%3BKasibhatla%2C+P+S%3BMcGraw%2C+R%3BSchwartz%2C+SE%3BSaxena%2C+V+K%3BYue%2C+G+K&rft.aulast=Wright&rft.aufirst=D&rft.date=2002-02-01&rft.volume=33&rft.issue=2&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aerosol+Science&rft.issn=00218502&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aerosols; Particle size ER - TY - JOUR T1 - Isolation, Characterization, and Identification of Bacteria Associated with the Zinc Hyperaccumulator Thlaspi caerulescens subsp. calaminaria AN - 744670334; 5435819 AB - We investigated bacterial populations associated with the Zn hyperaccumulator Thlaspi caerulescens subsp. calaminaria grown in a soil collected from an abandoned Zn-Pb mine and smelter in Plombieres, Belgium. The bacterial population of the nonrhizospheric soil consisted of typical soil bacteria, some exhibiting multiple heavy-metal resistance characteristics that often are associated with polluted substrates: 7.8% and 4% of the population survived in the presence of elevated levels of Zn (1 mM) and Cd (0.8 mM), respectively. For the bacterial population isolated from the rhizosphere, the comparable survival rates were 88 and 78%. This observation indicates a selective enrichment of the metal-resistant strains due to an increased availability of the metals in soils near the roots compared with nonrhizospheric soil. The endophytic inhabitants of the roots and shoots were isolated, identified, and characterized. Although similar endophytic species were isolated from both compartments, those from the rhizoplane and roots showed lower resistance to Zn and Cd than the endophytic bacteria isolated from the shoots. In addition, root endophytic bacteria had additional requirements. Contrary to the rootresiding inhabitants, the shoot represented a niche rich in metal-resistant bacteria and even seemed to contain species that were exclusively abundant there. These differences in the characteristics of the bacterial microflora associated with T. caerulescens might possibly reflect altered metal speciation in the different soils and plant compartments studied. JF - International Journal of Phytoremediation AU - Lodewyckx, C AU - Mergeay, M AU - Vangronsveld, J AU - Clijsters, H AU - Van Der Lelie, D AD - Vito, Environmental Technology, Boeretang 200, B-2400 Mol, Belgium, vdelied@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 101 EP - 115 PB - CRC Press LLC VL - 4 IS - 2 SN - 1522-6514, 1522-6514 KW - Microbiology Abstracts B: Bacteriology KW - Speciation KW - Heavy metals KW - Endophytes KW - Belgium KW - Rhizosphere KW - Zinc KW - Thlaspi caerulescens KW - Microflora KW - Cadmium KW - Smelters KW - Lead KW - J 02704:Enumeration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744670334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Phytoremediation&rft.atitle=Isolation%2C+Characterization%2C+and+Identification+of+Bacteria+Associated+with+the+Zinc+Hyperaccumulator+Thlaspi+caerulescens+subsp.+calaminaria&rft.au=Lodewyckx%2C+C%3BMergeay%2C+M%3BVangronsveld%2C+J%3BClijsters%2C+H%3BVan+Der+Lelie%2C+D&rft.aulast=Lodewyckx&rft.aufirst=C&rft.date=2002-01-01&rft.volume=4&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Phytoremediation&rft.issn=15226514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Speciation; Endophytes; Heavy metals; Rhizosphere; Zinc; Microflora; Cadmium; Smelters; Lead; Thlaspi caerulescens; Belgium ER - TY - JOUR T1 - Mechanism of action of methylphenidate: insights from PET imaging studies. AN - 72873562; 12685517 AB - Methylphenidate (MPH) is the most commonly prescribed drug for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD). We have used Positron Emission Tomography (PET) to investigate the mechanism of action of MPH in the human brain. We have shown (a) that oral MPH reaches peak concentration in the brain 60-90 minutes after its administration, (b) that therapeutic doses of MPH block more than 50% of the dopamine transporters (DAT), and (c) that of the two enantiomers that compose MPH, it is d-threo-methylphenidate (d-MPH) and not l-threo-methylphenidate (l-MPH) that binds to the DAT. We have also shown that therapeutic doses of MPH significantly enhance extracellular dopamine (DA) in the basal ganglia, which is an effect that appears to be modulated by the rate of DA release and that is affected by age (older subjects show less effect). Thus, we postulate (a) that MPH's therapeutic effects are in part due to amplification of DA signals, (b) that variability in responses is in part due to differences in DA tone between subjects, and (c) that MPH's effects are context dependent. Because DA enhances task specific neuronal signaling and decreases noise, we also postulate that MPH-induced increases in DA could improve attention and decrease distractibility; and that since DA modulates motivation, the increases in DA would also enhance the saliency of the task facilitating the 'interest it elicits' and thus improving performance. JF - Journal of attention disorders AU - Volkow, N D AU - Fowler, J S AU - Wang, G AU - Ding, Y AU - Gatley, S J AD - Medical Department,Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - S31 EP - S43 VL - 6 Suppl 1 SN - 1087-0547, 1087-0547 KW - Central Nervous System Stimulants KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Membrane Glycoproteins KW - Membrane Transport Modulators KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - SLC6A3 protein, human KW - Methylphenidate KW - 207ZZ9QZ49 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Stereoisomerism KW - Humans KW - Dopamine -- metabolism KW - Child KW - Brain Mapping KW - Membrane Transport Proteins -- antagonists & inhibitors KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - Basal Ganglia -- diagnostic imaging KW - Basal Ganglia -- drug effects KW - Membrane Transport Proteins -- metabolism KW - Brain -- drug effects KW - Central Nervous System Stimulants -- therapeutic use KW - Methylphenidate -- pharmacokinetics KW - Methylphenidate -- therapeutic use KW - Central Nervous System Stimulants -- adverse effects KW - Brain -- diagnostic imaging KW - Attention Deficit Disorder with Hyperactivity -- drug therapy KW - Methylphenidate -- adverse effects KW - Tomography, Emission-Computed KW - Attention Deficit Disorder with Hyperactivity -- diagnostic imaging KW - Central Nervous System Stimulants -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72873562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+attention+disorders&rft.atitle=Mechanism+of+action+of+methylphenidate%3A+insights+from+PET+imaging+studies.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWang%2C+G%3BDing%2C+Y%3BGatley%2C+S+J&rft.aulast=Volkow&rft.aufirst=N&rft.date=2002-01-01&rft.volume=6+Suppl+1&rft.issue=&rft.spage=S31&rft.isbn=&rft.btitle=&rft.title=Journal+of+attention+disorders&rft.issn=10870547&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-22 N1 - Date created - 2003-04-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Sulfur polymer solidification/stabilization of elemental mercury waste. AN - 71601917; 11952179 AB - Elemental mercury, contaminated with radionuclides, presents a waste disposal problem throughout the Department of Energy complex. In this paper we describe a new process to immobilize elemental mercury wastes, including those contaminated with radionuclides, in a form that is non-dispersible, will meet EPA leaching criteria, and has low mercury vapor pressure. In this stabilization and solidification process, elemental mercury is combined with an excess of powdered sulfur polymer cement (SPC) and sulfide additives in a mixing vessel and heated to approximately 40 degrees C for several hours, until all of the mercury is converted into mercuric sulfide (HgS). Additional SPC is then added and the temperature of the mixture raised to 135 degrees C, resulting in a molten liquid which is poured into a mold where it cools and solidifies. The final treated waste was characterized by powder X-ray diffraction and found to be a mixture of the hexagonal and orthorhombic forms of mercuric sulfide. The Toxicity Characteristic Leaching Procedure was used to assess mercury releases, which for the optimized process averaged 25.8 microg/l, with some samples being well below the new EPA Universal Treatment Standard of 25 microg/l. Longer term leach tests were also conducted, indicating that the leaching process was dominated by diffusion. Values for the effective diffusion coefficient averaged 7.6x10(-18) cm2/s. Concentrations of mercury vapor from treated waste in equilibrium static headspace tests averaged 0.6 mg/m3. JF - Waste management (New York, N.Y.) AU - Fuhrmann, M AU - Melamed, D AU - Kalb, P D AU - Adams, J W AU - Milian, L W AD - Environmental Research & Technology Division, Environmental Sciences Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. fuhrmann@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 327 EP - 333 VL - 22 IS - 3 SN - 0956-053X, 0956-053X KW - Polymers KW - 0 KW - Sulfur Compounds KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - Environmental Pollution -- prevention & control KW - Temperature KW - Diffusion KW - Sulfur Compounds -- chemistry KW - Refuse Disposal KW - Polymers -- chemistry KW - Mercury -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71601917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Waste+management+%28New+York%2C+N.Y.%29&rft.atitle=Sulfur+polymer+solidification%2Fstabilization+of+elemental+mercury+waste.&rft.au=Fuhrmann%2C+M%3BMelamed%2C+D%3BKalb%2C+P+D%3BAdams%2C+J+W%3BMilian%2C+L+W&rft.aulast=Fuhrmann&rft.aufirst=M&rft.date=2002-01-01&rft.volume=22&rft.issue=3&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Waste+management+%28New+York%2C+N.Y.%29&rft.issn=0956053X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-09-17 N1 - Date created - 2002-04-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - BOOK T1 - Translating natural concentrations and fluxes into safety indicators for radioactive waste repositories AN - 51648232; 2006-005846 JF - International conference Uranium mining and hydrogeology III and the International Mine Water Association symposium AU - Lemos, Francisco AU - Sullivan, Terry AU - Friese, Kurt AU - Ross, Timothy AU - Barbosa, Maria A2 - Merkel, Broder J. A2 - Planer-Friedrich, Britta A2 - Wolkersdorfer, Christian Y1 - 2002 PY - 2002 DA - 2002 PB - Springer-Verlag, Berlin SN - 3540439277 KW - concentration KW - sorption KW - chemical dispersion KW - site exploration KW - waste disposal sites KW - radioactive waste KW - ground water KW - fuzzy logic KW - case studies KW - safety KW - mathematical methods KW - waste disposal KW - pH KW - Eh KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51648232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Lemos%2C+Francisco%3BSullivan%2C+Terry%3BFriese%2C+Kurt%3BRoss%2C+Timothy%3BBarbosa%2C+Maria&rft.aulast=Lemos&rft.aufirst=Francisco&rft.date=2002-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=3540439277&rft.btitle=Translating+natural+concentrations+and+fluxes+into+safety+indicators+for+radioactive+waste+repositories&rft.title=Translating+natural+concentrations+and+fluxes+into+safety+indicators+for+radioactive+waste+repositories&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - International conference Uranium mining and hydrogeology III and the International Mine Water Association symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Microbial transformations of uranium complexed with organic and inorganic ligands AN - 51643753; 2006-005881 JF - International conference Uranium mining and hydrogeology III and the International Mine Water Association symposium AU - Francis, Arokiasamy J A2 - Merkel, Broder J. A2 - Planer-Friedrich, Britta A2 - Wolkersdorfer, Christian Y1 - 2002 PY - 2002 DA - 2002 PB - Springer-Verlag, Berlin SN - 3540439277 KW - soils KW - sorption KW - metabolism KW - oxidation KW - pollution KW - solubility KW - bioremediation KW - environmental effects KW - remediation KW - waste management KW - metals KW - bacteria KW - uranium KW - actinides KW - microorganisms KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51643753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Francis%2C+Arokiasamy+J&rft.aulast=Francis&rft.aufirst=Arokiasamy&rft.date=2002-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=3540439277&rft.btitle=Microbial+transformations+of+uranium+complexed+with+organic+and+inorganic+ligands&rft.title=Microbial+transformations+of+uranium+complexed+with+organic+and+inorganic+ligands&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - International conference Uranium mining and hydrogeology III and the International Mine Water Association symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 12 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Phytoremediation; European and American trends; successes, obstacles and needs AN - 51633102; 2006-015932 AB - Phytoremediation is an emerging technology based on the use of green plants to remove, contain, inactivate or destroy harmful environmental pollutants. Recent developments in Europe and the USA show that the approach is somewhat different on both sides of the Atlantic. In Europe, phytoremediation has more basically been research driven and, based on the outcomes, applications have been envisaged. By contrast, the approach in the USA is more application and experience driven. In spite of a growing track record of commercial success, more demonstration projects are needed to prove that phytoremediation is effective in order to rigorously measure its underlying economics, and to expand its applications. More fundamental research is also required to better understand the complex interactions between pollutants, soil, plant roots and micro-organisms at the rhizosphere level, to increase the bioavailability of pollutants, to fully exploit the metabolic diversity of plants and, thus, to successfully implement this new green technology. JF - Journal of Soils and Sediments AU - Schwitzguebel, Jean-Paul AU - van der Lelie, Daniel AU - Baker, Alan AU - Glass, David J AU - Vangronsveld, Jaco Y1 - 2002 PY - 2002 DA - 2002 SP - 91 EP - 99 PB - Ecomed Publishers, Landsberg VL - 2 IS - 2 SN - 1439-0108, 1439-0108 KW - soils KW - toxic materials KW - technology KW - isotopes KW - pollutants KW - metabolism KW - soil treatment KW - pollution KW - biosurfactants KW - bioremediation KW - remediation KW - ground water KW - radioactive isotopes KW - surfactants KW - phytoremediation KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51633102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Soils+and+Sediments&rft.atitle=Phytoremediation%3B+European+and+American+trends%3B+successes%2C+obstacles+and+needs&rft.au=Schwitzguebel%2C+Jean-Paul%3Bvan+der+Lelie%2C+Daniel%3BBaker%2C+Alan%3BGlass%2C+David+J%3BVangronsveld%2C+Jaco&rft.aulast=Schwitzguebel&rft.aufirst=Jean-Paul&rft.date=2002-01-01&rft.volume=2&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+Soils+and+Sediments&rft.issn=14390108&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 76 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bioremediation; biosurfactants; ground water; isotopes; metabolism; microorganisms; phytoremediation; pollutants; pollution; radioactive isotopes; remediation; soil treatment; soils; surfactants; technology; toxic materials ER - TY - JOUR T1 - Silica recovery; a promising option to reduce geothermal power production costs AN - 51139240; 2005-009586 AB - In the development of geothermal resources, the co-production of minerals and chemicals is a promising cost-efficient strategy that would lower geothermal power production costs. The potential for commercial geothermal silica extraction from low salinity geothermal brine is enhanced due to a small chance of incorporation of other mineral species that are present at a low concentration. Selective extractions and subsequent purification are not complicated and are attractive in terms of an economically feasible recovery process. An economic assessment based on pilot plant tests is presented. JF - Transactions - Geothermal Resources Council AU - Lin, Mow S AU - Premuzic, Eugene T AU - Zhou, Wei M AU - Dong, Bin AU - DeRocher, Ted AU - Johnson, Stuart D AU - Bloomquist, R Gordon Y1 - 2002 PY - 2002 DA - 2002 SP - 149 EP - 152 PB - GRC - Geothermal Resources Council, Davis, CA VL - 26 SN - 0193-5933, 0193-5933 KW - geothermal energy KW - physical properties KW - silica KW - brines KW - chemical properties KW - purification KW - economics KW - byproducts KW - production KW - cost KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51139240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+-+Geothermal+Resources+Council&rft.atitle=Silica+recovery%3B+a+promising+option+to+reduce+geothermal+power+production+costs&rft.au=Lin%2C+Mow+S%3BPremuzic%2C+Eugene+T%3BZhou%2C+Wei+M%3BDong%2C+Bin%3BDeRocher%2C+Ted%3BJohnson%2C+Stuart+D%3BBloomquist%2C+R+Gordon&rft.aulast=Lin&rft.aufirst=Mow&rft.date=2002-01-01&rft.volume=26&rft.issue=&rft.spage=149&rft.isbn=0934412863&rft.btitle=&rft.title=Transactions+-+Geothermal+Resources+Council&rft.issn=01935933&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geothermal Resources Council 2002 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 16 N1 - PubXState - CA N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - brines; byproducts; chemical properties; cost; economics; geothermal energy; physical properties; production; purification; silica ER - TY - JOUR T1 - Biological Remediation of Explosives and Related Nitroaromatic Compounds AN - 21144150; 8803996 AB - Nitroaromatics form an important group of recalcitrant xenobiotics. Only few aromatic compounds, bearing one nitro group as a substituent of the aromatic ring, are produced as secondary metabolites by microorganisms. The majority of nitroaromatic compounds in the biosphere are industrial chemicals such as explosives, dyes, polyurethane foams, herbicides, insecticides and solvents. These compounds are generally recalcitrant to biological treatment and remain in the biosphere, where they constitute a source of pollution due to both toxic and mutagenic effects on humans, fish, algae and microorganisms. However, relatively few microorganisms have been described as being able to use nitroaromatic compounds as nitrogen and/or carbon and energy source. The best-known nitroaromatic compound is the explosive TNT (2,4,6-trinitrotoluene). This article reviews the bioremediation strategies for TNT-contaminated soil and water. It comes to the following conclusion: The optimal remediation strategy for nitroaromatic compounds depends on many site-specific factors. Composting and the use of reactor systems lend themselves to treating soils contaminated with high levels of explosives (e.g. at former ammunition production facilities, where areas with a high contamination level are common). Compared to composting systems, bioreactors have the major advantage of a short treatment time, but the disadvantage of being more labour intensive and more expensive. Studies indicate that biological treatment systems, which are based on the activity of the fungus Phanerochaete chrysosporium or on Pseudomonas sp. ST53, might be used as effective methods for the remediation of highly contaminated soil and water. Phytoremediation, although not widely used now, has the potential to become an important strategy for the remediation of soil and water contaminated with explosives. It is best suited where contaminant levels are low (e.g. at military sites where pollution is rather diffuse) and where larger contaminated surfaces or volumes have to be treated. In addition, phytoremediation can be used as a polishing method after other remediation treatments, such as composting or bioslurry, have taken place. This in-situ treatment method has the advantage of lower treatment costs, but has the disadvantage of a considerable longer treatment time. In order to improve the cost-efficiency, phytoremediation of nitroaromatics (and other organic xenobiotics) could be combined with bio-energy production. This requires, however, detailed knowledge on the fate of the contaminants in the plants as well as the development of efficient treatment methods for the contaminated biomass that minimise the spreading of the contaminants into the environment during post harvest treatment. JF - Environmental Science and Pollution Research International AU - Snellinx, Z AU - Nepovim, A AU - Taghavi, S AU - Vangronsveld, J AU - Vanek, T AU - van der Lelie, D AD - Environmental Technology, Flemish Institute for Technological Research (Vito), Boeretang 200, 2400 Mol, Belgium, vdlelied@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 48 EP - 61 VL - 9 IS - 1 SN - 0944-1344, 0944-1344 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Pollution Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts KW - Bioremediation KW - Contamination KW - Xenobiotics KW - Toxicity tests KW - Biological treatment KW - Soil KW - Insecticides KW - Phytoremediation KW - Bioreactors KW - polyurethane KW - Composting KW - phytoremediation KW - Algae KW - Soil contamination KW - Biomass KW - Dyes KW - Energy resources KW - Microorganisms KW - Explosives KW - Contaminants KW - Aromatics KW - Nitrogen KW - Phanerochaete chrysosporium KW - Spreading KW - secondary metabolites KW - Pollution effects KW - Pseudomonas KW - Biosphere KW - Recycling KW - Waste management KW - Aromatic compounds KW - 2,4,6-Trinitrotoluene KW - Carbon KW - Military KW - water pollution KW - Pollution KW - Solvents KW - Herbicides KW - Pollution research KW - Foams KW - Water pollution KW - Soil pollution KW - Energy KW - Secondary metabolites KW - Pollution control KW - ENA 03:Energy KW - A 01340:Antibiotics & Antimicrobials KW - Q5 08504:Effects on organisms KW - K 03450:Ecology KW - J 02400:Human Diseases KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21144150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+and+Pollution+Research+International&rft.atitle=Biological+Remediation+of+Explosives+and+Related+Nitroaromatic+Compounds&rft.au=Snellinx%2C+Z%3BNepovim%2C+A%3BTaghavi%2C+S%3BVangronsveld%2C+J%3BVanek%2C+T%3Bvan+der+Lelie%2C+D&rft.aulast=Snellinx&rft.aufirst=Z&rft.date=2002-01-01&rft.volume=9&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+and+Pollution+Research+International&rft.issn=09441344&rft_id=info:doi/10.1065%2Fespr2001.09.084.2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Bioremediation; Energy resources; Solvents; Microorganisms; Pollution effects; Toxicity tests; Water pollution; Aromatics; Pollution control; Spreading; Contamination; Biosphere; Xenobiotics; Soil; Carbon; 2,4,6-Trinitrotoluene; Insecticides; Aromatic compounds; Bioreactors; polyurethane; phytoremediation; Composting; Pollution; Algae; Pollution research; Herbicides; Foams; Biomass; Soil pollution; Dyes; Energy; Secondary metabolites; Explosives; Contaminants; Nitrogen; secondary metabolites; Soil contamination; Recycling; Waste management; Biological treatment; Phytoremediation; Military; water pollution; Phanerochaete chrysosporium; Pseudomonas DO - http://dx.doi.org/10.1065/espr2001.09.084.2 ER - TY - JOUR T1 - Biological Remediation of Explosives and Related Nitroaromatic Compounds AN - 20193064; 5493882 AB - Nitroaromatics form an important group of recalcitrant xenobiotics. Only few aromatic compounds, bearing one nitro group as a substituent of the aromatic ring, are produced as secondary metabolites by microorganisms. The majority of nitroaromatic compounds in the biosphere are industrial chemicals such as explosives, dyes, polyurethane foams, herbicides, insecticides and solvents. These compounds are generally recalcitrant to biological treatment and remain in the biosphere, where they constitute a source of pollution due to both toxic and mutagenic effects on humans, fish, algae and microorganisms. However, relatively few microorganisms have been described as being able to use nitroaromatic compounds as nitrogen and/or carbon and energy source. The best-known nitroaromatic compound is the explosive TNT (2,4,6-trinitrotoluene). This article reviews the bioremediation strategies for TNT-contaminated soil and water. It comes to the following conclusion: The optimal remediation strategy for nitroaromatic compounds depends on many site-specific factors. Composting and the use of reactor systems lend themselves to treating soils contaminated with high levels of explosives (e.g. at former ammunition production facilities, where areas with a high contamination level are common). Compared to composting systems, bioreactors have the major advantage of a short treatment time, but the disadvantage of being more labour intensive and more expensive. JF - Environmental Science and Regulation International AU - Snellinx, Z AU - Nepovim, A AU - Taghavi, S AU - Vangronsveld, J AU - Vanek, T AU - van der Lelie, D AD - Environmental Technology, Flemish Institute for Technological Research (Vito), Boeretang 200, 2400 Mol, Belgium, vdlelied@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 48 EP - 61 VL - 9 IS - 1 SN - 0944-1344, 0944-1344 KW - 2,4,6-trinitrotoluene KW - Bioremediation KW - Biosphere KW - Composting KW - Explosives KW - Soil remediation KW - Water purification KW - Xenobiotics KW - nitroaromatic compounds KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Pollution Abstracts KW - Contamination KW - Soil KW - Aromatic compounds KW - 2,4,6-Trinitrotoluene KW - Carbon KW - Insecticides KW - Bioreactors KW - polyurethane KW - Pollution KW - Algae KW - Solvents KW - Herbicides KW - Foams KW - Soil pollution KW - Dyes KW - Energy KW - Microorganisms KW - Secondary metabolites KW - Aromatics KW - Nitrogen KW - P 9000:ENVIRONMENTAL ACTION KW - A 01450:Environmental Pollution & Waste Treatment KW - K 03450:Ecology KW - W 30965:Miscellaneous, Reviews KW - W4 210:Bioremediation, Bioreactors & BioCycling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20193064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+and+Regulation+International&rft.atitle=Biological+Remediation+of+Explosives+and+Related+Nitroaromatic+Compounds&rft.au=Snellinx%2C+Z%3BNepovim%2C+A%3BTaghavi%2C+S%3BVangronsveld%2C+J%3BVanek%2C+T%3Bvan+der+Lelie%2C+D&rft.aulast=Snellinx&rft.aufirst=Z&rft.date=2002-01-01&rft.volume=9&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+and+Regulation+International&rft.issn=09441344&rft_id=info:doi/http%3A%2F%2Fdx.doi.org%2F10.1065%2Fespr2001.09.084.2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-12-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Bioremediation; Contamination; Biosphere; Xenobiotics; Soil; Insecticides; Carbon; 2,4,6-Trinitrotoluene; Aromatic compounds; Bioreactors; polyurethane; Composting; Pollution; Algae; Solvents; Herbicides; Foams; Soil pollution; Dyes; Energy; Microorganisms; Secondary metabolites; Explosives; Aromatics; Nitrogen; Soil remediation; Water purification DO - http://dx.doi.org/10.1065/espr2001.09.084.2 ER - TY - JOUR T1 - Non-framework cation migration and irreversible pressure-induced hydration in a zeolite AN - 1844921930; 2016-099816 AB - A synthetic zeolite analogue, K gallosilicate natrolite, shows irreversible P-induced (at < 1.29 GPa) hydration with retention of a high-P phase at ambient conditions. The structure of this high-P recovered phase is reported, and contrasted with the high-P phase of natrolite. The irreversible hydration behaviour is found to be associated with a rearrangement of the non-framework metal ions, which thus have an important role in mediating the overall properties of zeolites. JF - Nature (London) AU - Lee, Yongjae AU - Vogt, Thomas AU - Hriljac, Joseph A AU - Parisc, John B AU - Hanson, Jonathan C AU - Kim, Sun Jin Y1 - 2002 PY - 2002 DA - 2002 SP - 485 EP - 489 PB - Macmillan Journals, London VL - 420 IS - 6915 SN - 0028-0836, 0028-0836 KW - silicates KW - pressure KW - oxygen KW - three-dimensional models KW - tetrahedra KW - effects KW - crystal structure KW - high pressure KW - natrolite KW - hydration KW - polyhedra KW - aluminosilicates KW - zeolite group KW - cations KW - framework silicates KW - crystal chemistry KW - hydrostatic pressure KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844921930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+%28London%29&rft.atitle=Non-framework+cation+migration+and+irreversible+pressure-induced+hydration+in+a+zeolite&rft.au=Lee%2C+Yongjae%3BVogt%2C+Thomas%3BHriljac%2C+Joseph+A%3BParisc%2C+John+B%3BHanson%2C+Jonathan+C%3BKim%2C+Sun+Jin&rft.aulast=Lee&rft.aufirst=Yongjae&rft.date=2002-01-01&rft.volume=420&rft.issue=6915&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Nature+%28London%29&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature01265 L2 - http://www.nature.com/nature/index.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 2016-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2016-12-01 N1 - CODEN - NATUAS N1 - SubjectsTermNotLitGenreText - aluminosilicates; cations; crystal chemistry; crystal structure; effects; framework silicates; high pressure; hydration; hydrostatic pressure; natrolite; oxygen; polyhedra; pressure; silicates; tetrahedra; three-dimensional models; zeolite group DO - http://dx.doi.org/10.1038/nature01265 ER - TY - JOUR T1 - Arsenic oxidation state heterogeneity and correlations with mineralogy in mine waste solids from Yellowknife AN - 1039339282; 2012-080511 JF - Program with Abstracts - Geological Association of Canada; Mineralogical Association of Canada: Joint Annual Meeting AU - Walker, S R AU - Jamieson, H E AU - Hall, G E M AU - Sutton, S R AU - Lanzirotti, A AU - Anonymous Y1 - 2002 PY - 2002 DA - 2002 SP - 121 PB - Geological Association of Canada, Waterloo, ON VL - 27 SN - 0701-8738, 0701-8738 KW - Giant Mine KW - mines KW - mine waste KW - waste rock KW - oxidation KW - arsenic KW - X-ray spectra KW - Northwest Territories KW - XANES spectra KW - synchrotron radiation KW - flotation KW - Canada KW - Yellowknife Northwest Territories KW - metals KW - Con Mine KW - Western Canada KW - spectra KW - tailings KW - sulfides KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1039339282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Program+with+Abstracts+-+Geological+Association+of+Canada%3B+Mineralogical+Association+of+Canada%3A+Joint+Annual+Meeting&rft.atitle=Arsenic+oxidation+state+heterogeneity+and+correlations+with+mineralogy+in+mine+waste+solids+from+Yellowknife&rft.au=Walker%2C+S+R%3BJamieson%2C+H+E%3BHall%2C+G+E+M%3BSutton%2C+S+R%3BLanzirotti%2C+A%3BAnonymous&rft.aulast=Walker&rft.aufirst=S&rft.date=2002-01-01&rft.volume=27&rft.issue=&rft.spage=121&rft.isbn=0919216811&rft.btitle=&rft.title=Program+with+Abstracts+-+Geological+Association+of+Canada%3B+Mineralogical+Association+of+Canada%3A+Joint+Annual+Meeting&rft.issn=07018738&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - MAC-GAC joint annual meeting, Saskatoon 2000; from plains to shield; the making of a continent's interior N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2012-01-01 N1 - PubXState - ON N1 - Last updated - 2012-09-14 N1 - CODEN - PAACD6 N1 - SubjectsTermNotLitGenreText - arsenic; Canada; Con Mine; flotation; Giant Mine; metals; mine waste; mines; Northwest Territories; oxidation; spectra; sulfides; synchrotron radiation; tailings; waste rock; Western Canada; X-ray spectra; XANES spectra; Yellowknife Northwest Territories ER - TY - JOUR T1 - Roles of two conserved cysteine residues in the activation of human adenovirus proteinase. AN - 72308072; 11724559 AB - The roles of two conserved cysteine residues involved in the activation of the adenovirus proteinase (AVP) were investigated. AVP requires two cofactors for maximal activity, the 11-amino acid peptide pVIc (GVQSLKRRRCF) and the viral DNA. In the AVP-pVIc crystal structure, conserved Cys104 of AVP has formed a disulfide bond with conserved Cys10 of pVIc. In this work, pVIc formed a homodimer via disulfide bond formation with a second-order rate constant of 0.12 M(-1) s(-1), and half of the homodimer could covalently bind to AVP via thiol-disulfide exchange. Alternatively, monomeric pVIc could form a disulfide bond with AVP via oxidation. Regardless of the mechanism by which AVP becomes covalently bound to pVIc, the kinetic constants for substrate hydrolysis were the same. The equilibrium dissociation constant, K(d), for the reversible binding of pVIc to AVP was 4.4 microM. The K(d) for the binding of the mutant C10A-pVIc was at least 100-fold higher. Surprisingly, the K(d) for the binding of the C10A-pVIc mutant to AVP decreased at least 60-fold, to 6.93 microM, in the presence of 12mer ssDNA. Furthermore, once the mutant C10A-pVIc was bound to an AVP-DNA complex, the macroscopic kinetic constants for substrate hydrolysis were the same as those exhibited by wild-type pVIc. Although the cysteine in pVIc is important in the binding of pVIc to AVP, formation of a disulfide bond between pVIc and AVP was not required for maximal stimulation of enzyme activity by pVIc. JF - Biochemistry AU - McGrath, W J AU - Baniecki, M L AU - Peters, E AU - Green, D T AU - Mangel, W F AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 2001/12/04/ PY - 2001 DA - 2001 Dec 04 SP - 14468 EP - 14474 VL - 40 IS - 48 SN - 0006-2960, 0006-2960 KW - DNA, Viral KW - 0 KW - Viral Proteins KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - adenain KW - EC 3.4.22.39 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Structure, Secondary KW - Models, Molecular KW - Enzyme Activation KW - Kinetics KW - Humans KW - In Vitro Techniques KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Statistics as Topic KW - DNA, Viral -- metabolism KW - Binding Sites KW - Viral Proteins -- genetics KW - Cysteine -- chemistry KW - Cysteine Endopeptidases -- metabolism KW - Cysteine Endopeptidases -- chemistry KW - Adenoviruses, Human -- genetics KW - Viral Proteins -- chemistry KW - Viral Proteins -- metabolism KW - Cysteine Endopeptidases -- genetics KW - Adenoviruses, Human -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72308072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Roles+of+two+conserved+cysteine+residues+in+the+activation+of+human+adenovirus+proteinase.&rft.au=McGrath%2C+W+J%3BBaniecki%2C+M+L%3BPeters%2C+E%3BGreen%2C+D+T%3BMangel%2C+W+F&rft.aulast=McGrath&rft.aufirst=W&rft.date=2001-12-04&rft.volume=40&rft.issue=48&rft.spage=14468&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-08 N1 - Date created - 2001-11-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Topiramate selectively attenuates nicotine-induced increases in monoamine release. AN - 72358237; 11746717 JF - Synapse (New York, N.Y.) AU - Schiffer, W K AU - Gerasimov, M R AU - Marsteller, D A AU - Geiger, J AU - Barnett, C AU - Alexoff, D L AU - Dewey, S L AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA. wynne@bnl.gov Y1 - 2001/12/01/ PY - 2001 DA - 2001 Dec 01 SP - 196 EP - 198 VL - 42 IS - 3 SN - 0887-4476, 0887-4476 KW - Anticonvulsants KW - 0 KW - Biogenic Monoamines KW - Nicotinic Agonists KW - topiramate KW - 0H73WJJ391 KW - Fructose KW - 30237-26-4 KW - Serotonin KW - 333DO1RDJY KW - Nicotine KW - 6M3C89ZY6R KW - Dopamine KW - VTD58H1Z2X KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Microdialysis KW - Animals KW - Drug Interactions KW - Norepinephrine -- metabolism KW - Brain Chemistry -- drug effects KW - Dopamine -- metabolism KW - Serotonin -- metabolism KW - Anticonvulsants -- pharmacology KW - Fructose -- analogs & derivatives KW - Nicotine -- pharmacology KW - Nicotinic Agonists -- pharmacology KW - Biogenic Monoamines -- metabolism KW - Fructose -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72358237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Topiramate+selectively+attenuates+nicotine-induced+increases+in+monoamine+release.&rft.au=Schiffer%2C+W+K%3BGerasimov%2C+M+R%3BMarsteller%2C+D+A%3BGeiger%2C+J%3BBarnett%2C+C%3BAlexoff%2C+D+L%3BDewey%2C+S+L&rft.aulast=Schiffer&rft.aufirst=W&rft.date=2001-12-01&rft.volume=42&rft.issue=3&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-05 N1 - Date created - 2001-12-17 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. AN - 72314604; 11729018 AB - OBJECTIVEThe role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamine D2 receptors. In cocaine abusers, low levels of D2 receptors are associated with a lower level of metabolism in the orbitofrontal cortex. Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers.METHODFifteen methamphetamine abusers and 20 non-drug-abusing comparison subjects were studied with positron emission tomography (PET) and [11C]raclopride to assess the availability of dopamine D2 receptors and with [18F]fluorodeoxyglucose to assess regional brain glucose metabolism, a marker of brain function.RESULTSMethamphetamine abusers had a significantly lower level of D2 receptor availability than comparison subjects (a difference of 16% in the caudate and 10% in the putamen). D2 receptor availability was associated with metabolic rate in the orbitofrontal cortex in abusers and in comparison subjects.CONCLUSIONSLower levels of dopamine D2 receptor availability have been previously reported in cocaine abusers, alcoholics, and heroine abusers. This study extends this finding to methamphetamine abusers. The association between level of dopamine D2 receptors and metabolism in the orbitofrontal cortex in methamphetamine abusers, which replicates previous findings in cocaine abusers, suggests that D2 receptor-mediated dysregulation of the orbitofrontal cortex could underlie a common mechanism for loss of control and compulsive drug intake in drug-addicted subjects. JF - The American journal of psychiatry AU - Volkow, N D AU - Chang, L AU - Wang, G J AU - Fowler, J S AU - Ding, Y S AU - Sedler, M AU - Logan, J AU - Franceschi, D AU - Gatley, J AU - Hitzemann, R AU - Gifford, A AU - Wong, C AU - Pappas, N AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. volkow@bnl.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 2015 EP - 2021 VL - 158 IS - 12 SN - 0002-953X, 0002-953X KW - Receptors, Dopamine D2 KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Abridged Index Medicus KW - Index Medicus KW - Compulsive Behavior -- diagnostic imaging KW - Risk Factors KW - Humans KW - Adult KW - Male KW - Female KW - Compulsive Behavior -- physiopathology KW - Frontal Lobe -- physiopathology KW - Methamphetamine -- administration & dosage KW - Frontal Lobe -- drug effects KW - Methamphetamine -- adverse effects KW - Frontal Lobe -- diagnostic imaging KW - Energy Metabolism -- physiology KW - Energy Metabolism -- drug effects KW - Amphetamine-Related Disorders -- diagnostic imaging KW - Tomography, Emission-Computed KW - Receptors, Dopamine D2 -- drug effects KW - Receptors, Dopamine D2 -- physiology KW - Amphetamine-Related Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72314604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Low+level+of+brain+dopamine+D2+receptors+in+methamphetamine+abusers%3A+association+with+metabolism+in+the+orbitofrontal+cortex.&rft.au=Volkow%2C+N+D%3BChang%2C+L%3BWang%2C+G+J%3BFowler%2C+J+S%3BDing%2C+Y+S%3BSedler%2C+M%3BLogan%2C+J%3BFranceschi%2C+D%3BGatley%2C+J%3BHitzemann%2C+R%3BGifford%2C+A%3BWong%2C+C%3BPappas%2C+N&rft.aulast=Volkow&rft.aufirst=N&rft.date=2001-12-01&rft.volume=158&rft.issue=12&rft.spage=2015&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-02 N1 - Date created - 2001-11-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. AN - 72290737; 11717374 AB - Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant loss of DA transporters (used as markers of the DA terminal) that are associated with slower motor function and decreased memory. The extent to which the loss of DA transporters predisposes methamphetamine abusers to neurodegenerative disorders such as Parkinsonism is unclear and may depend in part on the degree of recovery. Here we assessed the effects of protracted abstinence on the loss of DA transporters in striatum, in methamphetamine abusers using positron emission tomography and [(11)C]d-threo-methylphenidate (DA transporter radioligand). Brain DA transporters in five methamphetamine abusers evaluated during short abstinence (<6 months) and then retested during protracted abstinence (12-17 months) showed significant increases with protracted abstinence (caudate, +19%; putamen, +16%). Although performance in some of the tests for which we observed an association with DA transporters showed some improvement, this effect was not significant. The DA transporter increases with abstinence could indicate that methamphetamine-induced DA transporter loss reflects temporary adaptive changes (i.e., downregulation), that the loss reflects DA terminal damage but that terminals can recover, or that remaining viable terminals increase synaptic arborization. Because neuropsychological tests did not improve to the same extent, this suggests that the increase of the DA transporters was not sufficient for complete function recovery. These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Volkow, N D AU - Chang, L AU - Wang, G J AU - Fowler, J S AU - Franceschi, D AU - Sedler, M AU - Gatley, S J AU - Miller, E AU - Hitzemann, R AU - Ding, Y S AU - Logan, J AD - Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2001/12/01/ PY - 2001 DA - 2001 Dec 01 SP - 9414 EP - 9418 VL - 21 IS - 23 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Methylphenidate KW - 207ZZ9QZ49 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Caudate Nucleus -- metabolism KW - Humans KW - Caudate Nucleus -- drug effects KW - Cerebellum -- metabolism KW - Cerebellum -- drug effects KW - Adult KW - Putamen -- metabolism KW - Tomography, Emission-Computed KW - Neuropsychological Tests KW - Time Factors KW - Female KW - Male KW - Putamen -- drug effects KW - Amphetamine-Related Disorders -- metabolism KW - Membrane Transport Proteins -- deficiency KW - Methamphetamine -- adverse effects KW - Amphetamine-Related Disorders -- rehabilitation KW - Membrane Transport Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72290737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Loss+of+dopamine+transporters+in+methamphetamine+abusers+recovers+with+protracted+abstinence.&rft.au=Volkow%2C+N+D%3BChang%2C+L%3BWang%2C+G+J%3BFowler%2C+J+S%3BFranceschi%2C+D%3BSedler%2C+M%3BGatley%2C+S+J%3BMiller%2C+E%3BHitzemann%2C+R%3BDing%2C+Y+S%3BLogan%2C+J&rft.aulast=Volkow&rft.aufirst=N&rft.date=2001-12-01&rft.volume=21&rft.issue=23&rft.spage=9414&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-11 N1 - Date created - 2001-11-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The WRDA program and emerging decontamination technologies for contaminated sediments AN - 50899968; 2002-065894 JF - AEHS Contaminated Soil Sediment & Water AU - Wenning, Richard J AU - Stern, Eric A AU - Jones, Keith W AU - Douglas, W Scott Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 38 EP - 41 PB - Association for Environmental Health and Sciences (AEHS), Amherst, MA VL - 2001, December SN - 1533-4155, 1533-4155 KW - United States KW - regulations KW - techniques KW - remediation KW - waste management KW - decontamination KW - sediments KW - waterways KW - estuarine environment KW - discharge KW - heavy metals KW - programs KW - WRDA KW - monitoring KW - Water Resources Development Act KW - harbors KW - pollution KW - decision-making KW - dredged materials KW - organic compounds KW - New York KW - industrial waste KW - hydrocarbons KW - polycyclic aromatic hydrocarbons KW - coastal environment KW - policy KW - economics KW - New Jersey KW - waste disposal KW - pesticides KW - aromatic hydrocarbons KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50899968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AEHS+Contaminated+Soil+Sediment+%26+Water&rft.atitle=The+WRDA+program+and+emerging+decontamination+technologies+for+contaminated+sediments&rft.au=Wenning%2C+Richard+J%3BStern%2C+Eric+A%3BJones%2C+Keith+W%3BDouglas%2C+W+Scott&rft.aulast=Wenning&rft.aufirst=Richard&rft.date=2001-12-01&rft.volume=2001%2C+December&rft.issue=&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=AEHS+Contaminated+Soil+Sediment+%26+Water&rft.issn=15334155&rft_id=info:doi/ L2 - http://www.aehsmag.com/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - MA N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aromatic hydrocarbons; coastal environment; decision-making; decontamination; discharge; dredged materials; economics; estuarine environment; harbors; heavy metals; hydrocarbons; industrial waste; monitoring; New Jersey; New York; organic compounds; pesticides; policy; pollution; polycyclic aromatic hydrocarbons; programs; regulations; remediation; sediments; techniques; United States; waste disposal; waste management; Water Resources Development Act; waterways; WRDA ER - TY - JOUR T1 - The structure and biochemistry of NADH-dependent cytochrome b5 reductase are now consistent. AN - 72256966; 11695905 AB - Cytochrome b5 reductase (cb5r) (EC 1.6.6.2) catalyzes the reduction of two molecules of cytochrome b5 using NADH as the physiological electron donor. The structure of pig cb5r at 2.4 A resolution was previously reported in the literature, but it was inconsistent with the biochemistry; for example, K83 and C245 were both implicated in the mechanism, but were not located at the active site. To address this problem, we have determined the structures of cb5r from rat at 2.0 A resolution and in a complex with NAD+ at 2.3 A resolution. We found significant differences throughout the rat structure compared to that of pig, including the locations of the lysine and cysteine residues mentioned above. To test the structural models, we made single amino acid substitutions of this lysine and showed that all substitutions produced correctly folded proteins and exhibited normal flavin behavior. However, the apparent kcat(NADH) decreased, and the apparent K(m) for NADH increased; the K(m)'s for cytochrome b5 were unchanged relative to that of the wild type. The largest effect was for the glutamate-substituted protein, which was further characterized using a charge transfer assay and found to be less efficient at NADH utilization than the wild type. These results are consistent with a role for this lysine in stabilizing the NADH-bound form of cb5r. We have concluded that the pig structure was mistraced in several regions and have reinterpreted mutants in these regions that give rise to the hereditary disease methemoglobinemia. JF - Biochemistry AU - Bewley, M C AU - Marohnic, C C AU - Barber, M J AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. bewley@bnl.gov Y1 - 2001/11/13/ PY - 2001 DA - 2001 Nov 13 SP - 13574 EP - 13582 VL - 40 IS - 45 SN - 0006-2960, 0006-2960 KW - NAD KW - 0U46U6E8UK KW - Cytochrome Reductases KW - EC 1.6.2.- KW - Cytochrome-B(5) Reductase KW - EC 1.6.2.2 KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Swine KW - Crystallization KW - Animals KW - Models, Molecular KW - Humans KW - Methemoglobinemia -- genetics KW - Amino Acid Sequence KW - Lysine -- genetics KW - Rats KW - NAD -- chemistry KW - Mutagenesis, Site-Directed KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - Sequence Homology, Amino Acid KW - Methemoglobinemia -- enzymology KW - Protein Conformation KW - Cytochrome Reductases -- genetics KW - Cytochrome Reductases -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72256966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=The+structure+and+biochemistry+of+NADH-dependent+cytochrome+b5+reductase+are+now+consistent.&rft.au=Bewley%2C+M+C%3BMarohnic%2C+C+C%3BBarber%2C+M+J&rft.aulast=Bewley&rft.aufirst=M&rft.date=2001-11-13&rft.volume=40&rft.issue=45&rft.spage=13574&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-11-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Human adenovirus proteinase: DNA binding and stimulation of proteinase activity by DNA. AN - 72236766; 11683632 AB - The interaction of the human adenovirus proteinase (AVP) with various DNAs was characterized. AVP requires two cofactors for maximal activity, the 11-amino acid residue peptide from the C-terminus of adenovirus precursor protein pVI (pVIc) and the viral DNA. DNA binding was monitored by changes in enzyme activity or by fluorescence anisotropy. The equilibrium dissociation constants for the binding of AVP and AVP-pVIc complexes to 12-mer double-stranded (ds) DNA were 63 and 2.9 nM, respectively. DNA binding was not sequence specific; the stoichiometry of binding was proportional to the length of the DNA. Three molecules of the AVP-pVIc complex bound to 18-mer dsDNA and six molecules to 36-mer dsDNA. When AVP-pVIc complexes bound to 12-mer dsDNA, two sodium ions were displaced from the DNA. A Delta of -4.6 kcal for the nonelectrostatic free energy of binding indicated that a substantial component of the binding free energy results from nonspecific interactions between the AVP-pVIc complex and DNA. The cofactors altered the interaction of the enzyme with the fluorogenic substrate (Leu-Arg-Gly-Gly-NH)2-rhodamine. In the absence of any cofactor, the Km was 94.8 microM and the kcat was 0.002 s(-1). In the presence of adenovirus DNA, the Km decreased 10-fold and the kcat increased 11-fold. In the presence of pVIc, the Km decreased 10-fold and the kcat increased 118-fold. With both cofactors present, the kcat/Km ratio increased 34000-fold, compared to that with AVP alone. Binding to DNA was coincident with stimulation of proteinase activity by DNA. Although other proteinases have been shown to bind to DNA, stimulation of proteinase activity by DNA is unprecedented. A model is presented suggesting that AVP moves along the viral DNA looking for precursor protein cleavage sites much like RNA polymerase moves along DNA looking for a promoter. JF - Biochemistry AU - McGrath, W J AU - Baniecki, M L AU - Li, C AU - McWhirter, S M AU - Brown, M T AU - Toledo, D L AU - Mangel, W F AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2001/11/06/ PY - 2001 DA - 2001 Nov 06 SP - 13237 EP - 13245 VL - 40 IS - 44 SN - 0006-2960, 0006-2960 KW - DNA Primers KW - 0 KW - DNA, Viral KW - Ligands KW - Peptide Fragments KW - Viral Proteins KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Fluorescence Polarization KW - Models, Molecular KW - Enzyme Activation KW - Kinetics KW - Humans KW - Protein Conformation KW - DNA Primers -- chemistry KW - Binding Sites KW - Viral Proteins -- genetics KW - Peptide Fragments -- metabolism KW - Peptide Fragments -- chemistry KW - Peptide Fragments -- genetics KW - Cysteine Endopeptidases -- metabolism KW - Cysteine Endopeptidases -- chemistry KW - Adenoviruses, Human -- genetics KW - Viral Proteins -- chemistry KW - Viral Proteins -- metabolism KW - Adenoviruses, Human -- enzymology KW - DNA, Viral -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72236766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Human+adenovirus+proteinase%3A+DNA+binding+and+stimulation+of+proteinase+activity+by+DNA.&rft.au=McGrath%2C+W+J%3BBaniecki%2C+M+L%3BLi%2C+C%3BMcWhirter%2C+S+M%3BBrown%2C+M+T%3BToledo%2C+D+L%3BMangel%2C+W+F&rft.aulast=McGrath&rft.aufirst=W&rft.date=2001-11-06&rft.volume=40&rft.issue=44&rft.spage=13237&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-10-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Crystallographic evidence for doxorubicin binding to the receptor-binding site in Clostridium botulinum neurotoxin B. AN - 72233921; 11679763 AB - The neurotoxins of Clostridium botulinum and tetanus bind to gangliosides as a first step of their toxin activity. Identifying suitable receptors that compete with gangliosides could prevent toxin binding to the neuronal cells. A possible ganglioside-binding site of the botulinum neurotoxin B (BoNT/B) has already been proposed and evidence is now presented for a drug binding to botulinum neurotoxin B from structural studies. Doxorubicin, a well known DNA intercalator, binds to the neurotoxin at the receptor-binding site proposed earlier. The structure of the BoNT/B-doxorubicin complex reveals that doxorubicin has interactions with the neurotoxin similar to those of sialyllactose. The aglycone moiety of the doxorubicin stacks with tryptophan 1261 and interacts with histidine 1240 of the binding domain. Here, the possibility is presented of designing a potential antagonist for these neurotoxins from crystallographic analysis of the neurotoxin-doxorubicin complex, which will be an excellent lead compound. JF - Acta crystallographica. Section D, Biological crystallography AU - Eswaramoorthy, S AU - Kumaran, D AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1743 EP - 1746 VL - 57 SN - 0907-4449, 0907-4449 KW - Bacterial Proteins KW - 0 KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Doxorubicin KW - 80168379AG KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Index Medicus KW - Crystallization KW - Models, Molecular KW - Crystallography, X-Ray KW - Protein Conformation KW - Binding Sites KW - Doxorubicin -- chemistry KW - Bacterial Proteins -- chemistry KW - Botulinum Toxins -- chemistry KW - Clostridium botulinum -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72233921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.atitle=Crystallographic+evidence+for+doxorubicin+binding+to+the+receptor-binding+site+in+Clostridium+botulinum+neurotoxin+B.&rft.au=Eswaramoorthy%2C+S%3BKumaran%2C+D%3BSwaminathan%2C+S&rft.aulast=Eswaramoorthy&rft.aufirst=S&rft.date=2001-11-01&rft.volume=57&rft.issue=&rft.spage=1743&rft.isbn=&rft.btitle=&rft.title=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.issn=09074449&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-20 N1 - Date created - 2001-10-26 N1 - Date revised - 2017-02-17 N1 - Genetic sequence - 1I1E; PDB N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Temperature-resolved synchrotron X-ray diffraction study of ramsdellite and groutite AN - 52035256; 2003-006487 AB - Ramsdellite is one of two naturally occurring polymorphs of MnO (sub 2) , and both natural and synthetic varieties are important battery materials. Ramsdellite has the diaspore structure, consisting of double chains of Mn-O octahedra that share corners to form a framework with rectangular-shaped tunnels. Post and Ross (1989) showed that most natural ramsdellite samples contain a second isostructural phase with unit-cell parameters intermediate between those of ramsdellite and groutite (MnOOH). We have refined the structure of the intermediate phase using the Rietveld method and synchrotron X-ray diffraction data that were collected at Beamline X7B, National Synchrotron Light Source, Brookhaven National Laboratory using a Mar345 imaging plate. The refinement shows longer mean Mn-O distances (1.93 Aa) relative to ramsdellite (1.89 Aa), and Jahn-Teller type distortion of the Mn-O octahedra. Both observations indicate substitution of Mn (super 3+) for about one-third of the Mn (super 4+) , presumably with coupled replacement of O (super 2-) with OH (super -) . Infra-red spectra from several samples confirm that the amount of OH (super -) is approximately proportional to the fraction of the intermediate phase. Temperature-resolved synchrotron diffraction experiments were performed for groutite and a sample with roughly equal amounts of ramsdellite and the intermediate phase. The fraction of the intermediate phase increased from approximately 50% to approximately 60% up to about 275 degrees C, and then decreased, until by 310 degrees C all of the intermediate phase had transformed to ramsdellite. A mass spectrometer monitoring effluents from the heated sample showed a water loss concurrent with the disappearance of the intermediate phase. From 310 to 450 degrees C, the ramsdellite gradually transformed to pyrolusite, but at the maximum temperature both phases remained. The groutite transformed to hausmannite and pyrolusite between approximately 250 and 290 degrees C. Between 400 and 460 degrees C the pyrolusite and hausmannite transformed to bixbyite. JF - Abstracts with Programs - Geological Society of America AU - Post, Jeffrey E AU - Heaney, Peter J AU - Hanson, Jonathan C AU - Anonymous Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 362 EP - 363 PB - Geological Society of America (GSA), Boulder, CO VL - 33 IS - 6 SN - 0016-7592, 0016-7592 KW - ramsdellite KW - experimental studies KW - X-ray diffraction data KW - crystal structure KW - Rietveld refinement KW - temperature KW - synchrotron radiation KW - laboratory studies KW - groutite KW - phase equilibria KW - oxides KW - transformations KW - industrial minerals KW - 28A:Economic geology, geology of nonmetal deposits KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52035256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Temperature-resolved+synchrotron+X-ray+diffraction+study+of+ramsdellite+and+groutite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+Peter+J%3BHanson%2C+Jonathan+C%3BAnonymous&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2001-11-01&rft.volume=33&rft.issue=6&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2001 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2003-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - crystal structure; experimental studies; groutite; industrial minerals; laboratory studies; oxides; phase equilibria; ramsdellite; Rietveld refinement; synchrotron radiation; temperature; transformations; X-ray diffraction data ER - TY - JOUR T1 - X-ray diffraction evidence for transition metal cation exchange in anionic clays in room-temperature aqueous fluids AN - 52034596; 2003-006486 AB - In anionic clays, trivalent cations within brucite-like octahedral sheets generate a net positive charge that is electrostatically balanced by anionic groups in the interlayer region. Many anionic clays exhibit a heightened ability to swap their interlayer anions with negatively charged species in solution, such as cyanide ions, pesticides, and radioactive wastes. Based on measurements of changes in fluid chemistry, Komarneni et al. (1998) have argued that hydrotalcite-like anionic clays can remove dissolved transition metal cations (e.g., Co (super 2+) , Ni (super 2+) , Zn (super 2+) , and Cu (super 2+) ) from solutions at room temperature by diadochic exchange reactions with octahedral Mg. We have examined the reaction products of hydrotalcite-like clays in the presence of dissolved transition metals using synchrotron X-ray powder diffraction, and our Rietveld analyses provide direct support for the proposed exchange model. Commercially prepared manasseite {[Mg (sub 6) (super 2+) Al (sub 2) (super 3+) (OH) (sub 16) ] (super 2+) . [CO (sub 3) .4H (sub 2) O] (super 2-) } powders (0.05 gm) were equilibrated at room temperature in 25 ml solutions at pH 4-5 with 0.01 M of CuCl (sub 2) and, separately, ZnCl (sub 2) for 24 hr at room temperature. Synchrotron X-ray diffraction data for the dried powders were collected at Beamline X7B, National Synchrotron Light Source, Brookhaven National Laboratory using a Mar345 imaging plate. Rietveld analyses of the starting and reacted powders were well-behaved with final weighted residuals below 0.04. The Cu-exchanged manasseite experiment generated a significant amount (57 wt%) of paratacamite [Cu (sub 2) Cl(OH) (sub 3) ] as a side-product with minor quantities of periclase. Occupancy factors for the octahedral sites in the cupric manasseite refined to 31% Cu and 69% Mg. Similarly, the Zn-exchanged manasseite yielded minor amounts of brucite, periclase, and zincite; octahedral occupancy factors for manasseite refined to 21% Zn and 79% Mg. Our analyses also have offered the first high-resolution structure refinement for endmember manasseite with a = 3.0534(1) Aa; and c = 22.964(2) Aa; in space group R-3m (R (sub wp) = 0.0285). Moreover, our temperature-resolved synchrotron heating experiments revealed that Cu-substituted manasseite exhibits a thermal stability that is very similar to the end-member composition, with both structures transforming reconstructively via dehydration reactions at approximately 150 degrees C. JF - Abstracts with Programs - Geological Society of America AU - Heaney, Peter J AU - Post, Jeffrey E AU - Hanson, Jonathan C AU - Komarneni, Sridhar AU - Anonymous Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 362 PB - Geological Society of America (GSA), Boulder, CO VL - 33 IS - 6 SN - 0016-7592, 0016-7592 KW - mineral interlayer KW - zinc KW - high-resolution methods KW - hydrotalcite KW - experimental studies KW - cobalt KW - X-ray diffraction data KW - copper KW - octahedra KW - clay mineralogy KW - manasseite KW - aqueous solutions KW - Rietveld refinement KW - synchrotron radiation KW - laboratory studies KW - polyhedra KW - metals KW - nickel KW - ion exchange KW - geochemistry KW - carbonates KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52034596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=X-ray+diffraction+evidence+for+transition+metal+cation+exchange+in+anionic+clays+in+room-temperature+aqueous+fluids&rft.au=Heaney%2C+Peter+J%3BPost%2C+Jeffrey+E%3BHanson%2C+Jonathan+C%3BKomarneni%2C+Sridhar%3BAnonymous&rft.aulast=Heaney&rft.aufirst=Peter&rft.date=2001-11-01&rft.volume=33&rft.issue=6&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2001 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2003-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - aqueous solutions; carbonates; clay mineralogy; cobalt; copper; experimental studies; geochemistry; high-resolution methods; hydrotalcite; ion exchange; laboratory studies; manasseite; metals; mineral interlayer; nickel; octahedra; polyhedra; Rietveld refinement; synchrotron radiation; X-ray diffraction data; zinc ER - TY - JOUR T1 - Assessing Phytoremediation's Progress in the United States and Europe AN - 19424233; 5323829 AB - Phytoremediation--using plants and trees to remove or neutralize contaminants--holds great promise for unobtrusively and cost-effectively treating soils, groundwater, and wastewaters contaminated with heavy metals, organic xenobiotics, and radionuclides. Although still an emerging technology, the phytoremediation market is fast-growing, especially in the United States and Europe. Like any other new approach, phytoremediation will only be accepted if its success is demonstrated. The key factors are low cost (compared to classical remediation techniques) and aesthetic aspects, making it suitable for remediating large contaminated sites in populated areas. JF - Environmental Science & Technology AU - Van Der Lelie, D AU - Schwitzguebel, J-P AU - Glass, D J AU - Vangronsveld, J AU - Baker, A AD - Brookhaven National Laboratory, Upton, NY, USA Y1 - 2001/11/01/ PY - 2001 DA - 2001 Nov 01 SP - 446 EP - 452A VL - 35 IS - 21 SN - 0013-936X, 0013-936X KW - Europe KW - USA KW - Biotechnology and Bioengineering Abstracts; Pollution Abstracts; Water Resources Abstracts; Aqualine Abstracts KW - Bioremediation KW - Phytoremediation KW - Pollution (Soil) KW - phytoremediation KW - W 30950:Waste Treatment & Pollution Clean-up KW - P 9000:ENVIRONMENTAL ACTION KW - SW 3070:Water quality control KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19424233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Assessing+Phytoremediation%27s+Progress+in+the+United+States+and+Europe&rft.au=Van+Der+Lelie%2C+D%3BSchwitzguebel%2C+J-P%3BGlass%2C+D+J%3BVangronsveld%2C+J%3BBaker%2C+A&rft.aulast=Van+Der+Lelie&rft.aufirst=D&rft.date=2001-11-01&rft.volume=35&rft.issue=21&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-08-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - phytoremediation; Phytoremediation; Pollution (Soil); Bioremediation; Europe ER - TY - JOUR T1 - Constitutive competence for genetic transformation in Streptococcus pneumoniae caused by mutation of a transmembrane histidine kinase AN - 18132239; 5277659 AB - Competence for DNA uptake and genetic transformation in Streptococcus pneumoniae is regulated by a quorum-sensing system. A competence-stimulating polypeptide (CSP) is secreted by the bacteria and acts back on the cells via a transmembrane histidine kinase. This enzyme phosphorylates a response regulator that activates synthesis of a SigH-like protein. The new sigma factor enables expression of a set of proteins transcribed from a novel promoter. A mutation called trt had been found that circumvented this regulation. The mutant cells are constitutively competent; that is, they can be transformed at low cell densities, in the presence of proteases that attack CSP, or during growth at low pH. In this work, cells containing trt were shown to be competent even in the presence of a comAB mutation that blocks secretion of CSP. The trt mutation was localized to comD, the gene encoding the transmembrane histidine kinase. A DNA segment of the trt mutant corresponding to comCDE was cloned, and it was shown to contain the trt mutation by its ability to confer constitutive competence. A two-step assay, which was based on transfer of trt to a wild strain and screening for transformability in the presence of trypsin, served to locate the trt mutation precisely. It corresponds to a GC arrow right AT transition, which changes Asp in the histidine kinase to Asn. This alteration in the carboxyl terminal half of the protein, which is cytoplasmically located and contains the phosphorylase activity, presumably alters the enzyme conformation so that it is permanently activated, independent of signals from the transmembrane domain. These results may help illuminate the mechanism by which external signals affect kinase action in two-component regulatory systems, and they may be of practical value in facilitating genetic studies by rendering pneumococcal strains permanently competent. JF - Molecular Microbiology AU - Lacks, SA AU - Greenberg, B AD - Department of Biology, Brookhaven National Laboratory, Upton, NY 11973, USA., lacks@bnl.gov Y1 - 2001/11// PY - 2001 DA - Nov 2001 SP - 1035 EP - 1045 PB - Blackwell Science Ltd VL - 42 IS - 4 SN - 0950-382X, 0950-382X KW - cDNA KW - amino acid sequence prediction KW - SigH protein KW - comA gene KW - comB gene KW - competence-stimulating polypeptide KW - trt gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Transformation KW - Histidine kinase KW - Streptococcus pneumoniae KW - Nucleotide sequence KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18132239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Constitutive+competence+for+genetic+transformation+in+Streptococcus+pneumoniae+caused+by+mutation+of+a+transmembrane+histidine+kinase&rft.au=Lacks%2C+SA%3BGreenberg%2C+B&rft.aulast=Lacks&rft.aufirst=SA&rft.date=2001-11-01&rft.volume=42&rft.issue=4&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1046%2Fj.1365-2958.2001.02697.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Histidine kinase; Transformation; Nucleotide sequence DO - http://dx.doi.org/10.1046/j.1365-2958.2001.02697.x ER - TY - JOUR T1 - Chemistry of NO2 on oxide surfaces: formation of NO3 on TiO2(110) and NO2O vacancy interactions. AN - 71200544; 11572680 AB - Synchrotron-based high-resolution photoemission, X-ray absorption near-edge spectroscopy, and first-principles density functional (DF) slab calculations were used to study the interaction of NO(2) with a TiO(2)(110) single crystal and powders of titania. The main product of the adsorption of NO(2) on TiO(2)(110) is surface nitrate with a small amount of chemisorbed NO(2). A similar result is obtained after the reaction of NO(2) with polycrystalline powders of TiO(2) or other oxide powders. This trend, however, does not imply that the metal centers of the oxides are unreactive toward NO(2). An unexpected mechanism is seen for the formation of NO(3). Photoemission data and DF calculations indicate that the surface nitrate forms through the disproportionation of NO(2) on Ti sites (2NO(2,ads) --> NO(3,ads) + NO(gas)) rather than direct adsorption of NO(2) on O centers of titania. Complex interactions take place between NO(2) and O vacancies of TiO(2)(110). Electronic states associated with O vacancies play a predominant role in the bonding and surface chemistry of NO(2). The adsorbed NO(2), on its part, affects the thermochemical stability of O vacancies, facilitating their migration from the bulk to the surface of titania. The behavior of the NO(2)/titania system illustrates the importance of surface and subsurface defects when using an oxide for trapping or destroying NO(x)() species in the prevention of environmental pollution (DeNOx operations). JF - Journal of the American Chemical Society AU - Rodriguez, J A AU - Jirsak, T AU - Liu, G AU - Hrbek, J AU - Dvorak, J AU - Maiti, A AD - Department of Chemistry, Brookhaven National Laboratory, Upton, New York 11953, USA. rodrigez@bnl.gov Y1 - 2001/10/03/ PY - 2001 DA - 2001 Oct 03 SP - 9597 EP - 9605 VL - 123 IS - 39 SN - 0002-7863, 0002-7863 KW - Environmental Pollutants KW - 0 KW - Nitrogen Oxides KW - Oxides KW - titanium dioxide KW - 15FIX9V2JP KW - nitrogen trioxide KW - 16E0524PXI KW - Titanium KW - D1JT611TNE KW - Nitrogen Dioxide KW - S7G510RUBH KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Environmental Pollutants -- chemical synthesis KW - Surface Properties KW - Titanium -- chemistry KW - Nitrogen Dioxide -- chemistry KW - Nitrogen Oxides -- chemistry KW - Oxygen -- chemistry KW - Oxides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71200544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Chemistry+of+NO2+on+oxide+surfaces%3A+formation+of+NO3+on+TiO2%28110%29+and+NO2%26lt%3B--%26gt%3BO+vacancy+interactions.&rft.au=Rodriguez%2C+J+A%3BJirsak%2C+T%3BLiu%2C+G%3BHrbek%2C+J%3BDvorak%2C+J%3BMaiti%2C+A&rft.aulast=Rodriguez&rft.aufirst=J&rft.date=2001-10-03&rft.volume=123&rft.issue=39&rft.spage=9597&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=00027863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-02 N1 - Date created - 2001-09-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cerebral glucose transport implies individualized glial cell function. AN - 85274573; pmid-11598493 AB - Previous positron emission tomography (PET) measurements of cerebral glucose transport using [11C]-3-O-methylglucose (CMG) suggested an interindividual variation in the values of the rate constant of tracer outflow (k2) larger than that for the clearance rate of inflow (K1). These two parameters were examined in healthy cerebral cortex by dynamic PET in 4 men and 2 women (aged 24 to 73 years) without neurologic disease, and in 1 man (42 years) with a recent left hemispheric cerebral infarction under normoglycemia (average blood plasma d-glucose concentration, 5.44 +/- 1.94 micromol/mL) and again under hyperglycemia (average, 10.24 +/- 1.44 micromol/mL). Time-radioactivity curves were obtained from healthy cortex (grey matter) and plasma and analyzed for the values of K1 and k2 by two graphical approaches and two fitting procedures. Both K1 and k2 significantly declined with increasing plasma glucose levels. A highly significant interindividual but not intraindividual variability for k2 was found at normoglycemia and hyperglycemia. The interindividual variability of K1, although borderline significant, was less than that of k2. Accordingly variable were the distribution volumes K1/k2. These data suggest individualized glial cell function and may be relevant to pathogenesis of neuropsychiatric disease. JF - Journal of Cerebral Blood Flow and Metabolism AU - Feinendegen, L E AU - Herzog, H AU - Thompson, K H AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. PY - 2001 SP - 1160 EP - 1170 VL - 21 IS - 10 SN - 0271-678X, 0271-678X KW - Reference Values KW - Cerebral Infarction KW - Human KW - Glucose KW - Aged KW - Fasting KW - Brain Diseases KW - Infection KW - Blood Glucose KW - Neuroglia KW - Lung Neoplasms KW - Kinetics KW - Glucose Clamp Technique KW - Adult KW - Middle Age KW - Tomography, Emission-Computed KW - 3-O-Methylglucose KW - Female KW - Male KW - Blood-Brain Barrier UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85274573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.atitle=Cerebral+glucose+transport+implies+individualized+glial+cell+function.&rft.au=Feinendegen%2C+L+E%3BHerzog%2C+H%3BThompson%2C+K+H&rft.aulast=Feinendegen&rft.aufirst=L&rft.date=2001-10-01&rft.volume=21&rft.issue=10&rft.spage=1160&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.issn=0271678X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Synchrotron X-ray fluorescence and secondary ion mass spectrometry in tree ring microanalysis; applications to dendroanalysis AN - 52153360; 2002-005214 JF - X-Ray Spectrometry AU - Martin, R R AU - Sham, T K AU - Won, G Wong AU - Jones, K W AU - Feng, H Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 338 EP - 341 PB - Wiley, Chichester VL - 30 IS - 5 SN - 0049-8246, 0049-8246 KW - methods KW - mining KW - Spermatophyta KW - ion probe data KW - lakes KW - mass spectra KW - Coniferales KW - atmospheric precipitation KW - environmental analysis KW - Pinus KW - apparatus KW - Sudbury Ontario KW - spectra KW - rain KW - pH KW - heavy metals KW - water KW - soils KW - Plantae KW - Gymnospermae KW - pollution KW - Pinus resinosa KW - Ontario KW - acid rain KW - Canada KW - tree rings KW - Daisy Lake KW - Pinaceae KW - trees KW - seasonal variations KW - Eastern Canada KW - instruments KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52153360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=X-Ray+Spectrometry&rft.atitle=Synchrotron+X-ray+fluorescence+and+secondary+ion+mass+spectrometry+in+tree+ring+microanalysis%3B+applications+to+dendroanalysis&rft.au=Martin%2C+R+R%3BSham%2C+T+K%3BWon%2C+G+Wong%3BJones%2C+K+W%3BFeng%2C+H&rft.aulast=Martin&rft.aufirst=R&rft.date=2001-10-01&rft.volume=30&rft.issue=5&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=X-Ray+Spectrometry&rft.issn=00498246&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 13 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - XRSPAX N1 - SubjectsTermNotLitGenreText - acid rain; apparatus; atmospheric precipitation; Canada; Coniferales; Daisy Lake; Eastern Canada; environmental analysis; Gymnospermae; heavy metals; instruments; ion probe data; lakes; mass spectra; methods; mining; Ontario; pH; Pinaceae; Pinus; Pinus resinosa; Plantae; pollution; rain; seasonal variations; soils; spectra; Spermatophyta; Sudbury Ontario; tree rings; trees; water ER - TY - JOUR T1 - Birnessite catalysis of the Maillard reaction; its significance in natural humification AN - 50152116; 2002-045461 AB - Although mineral colloids are known to play a significant role in transforming organic matter in soils and sediments, there still are many gaps in our understanding of the mechanisms of organic-mineral interactions. In this study, we investigated the role of a major oxide-mineral birnessite (a form of Mn(IV) oxide) in catalyzing the condensation reaction between sugars and amino acids, the Maillard reaction, for forming humic substances. The Maillard reaction is perceived to be a major pathway in natural humification. Using a suite of spectroscopic methods (including ESR, XANES, EXAFS and (super 13) C NMR), our results show that Mn(IV) oxide markedly accelerates the Maillard reaction between glucose and glycine at ranges of temperatures and pH typical of natural environments. These results demonstrate the importance of manganese oxide catalysis in the Maillard reaction, and its significance in the natural abiotic formation of humic substances. JF - Geophysical Research Letters AU - Jokic, A AU - Frenkel, A I AU - Vairavamurthy, M A AU - Huang, P M Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 3899 EP - 3902 PB - American Geophysical Union, Washington, DC VL - 28 IS - 20 SN - 0094-8276, 0094-8276 KW - soils KW - Maillard reaction KW - glycine KW - mechanism KW - humification KW - organic compounds KW - organic acids KW - chemical reactions KW - birnessite KW - amino acids KW - glucose KW - sediments KW - oxides KW - spectra KW - pH KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50152116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Birnessite+catalysis+of+the+Maillard+reaction%3B+its+significance+in+natural+humification&rft.au=Jokic%2C+A%3BFrenkel%2C+A+I%3BVairavamurthy%2C+M+A%3BHuang%2C+P+M&rft.aulast=Jokic&rft.aufirst=A&rft.date=2001-10-01&rft.volume=28&rft.issue=20&rft.spage=3899&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1029%2F2001GL013839 L2 - http://www.agu.org/journals/gl/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 25 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - GPRLAJ N1 - SubjectsTermNotLitGenreText - amino acids; birnessite; chemical reactions; glucose; glycine; humification; Maillard reaction; mechanism; organic acids; organic compounds; oxides; pH; sediments; soils; spectra DO - http://dx.doi.org/10.1029/2001GL013839 ER - TY - JOUR T1 - Cloning and Functional Analysis of the pbr Lead Resistance Determinant of Ralstonia metallidurans CH34 AN - 17907905; 5181570 AB - The lead resistance operon, pbr, of Ralstonia metallidurans (formerly Alcaligenes eutrophus) strain CH34 is unique, as it combines functions involved in uptake, efflux, and accumulation of Pb(II). The pbr lead resistance locus contains the following structural resistance genes: (i) pbrT, which encodes a Pb(II) uptake protein; (ii) pbrA, which encodes a P-type Pb(II) efflux ATPase; (iii) pbrB, which encodes a predicted integral membrane protein of unknown function; and (iv) pbrC, which encodes a predicted prolipoprotein signal peptidase. Downstream of pbrC, the pbrD gene, encoding a Pb(II)-binding protein, was identified in a region of DNA, which was essential for functional lead sequestration. Pb(II)-dependent inducible transcription of pbrABCD from the PpbrA promoter is regulated by PbrR, which belongs to the MerR family of metal ion-sensing regulatory proteins. This is the first report of a mechanism for specific lead resistance in any bacterial genus. JF - Journal of Bacteriology AU - Borremans, B AU - Hobman, J L AU - Provoost, A AU - Brown, N L AU - van der Lelie, D AD - Brookhaven National Laboratory (BNL), Biology Department, Upton, NY 11973-5000., vdlelied@bnl.gov Y1 - 2001/10// PY - 2001 DA - Oct 2001 SP - 5651 EP - 5658 VL - 183 IS - 19 SN - 0021-9193, 0021-9193 KW - cDNA KW - amino acid sequence prediction KW - MeerR protein KW - pbrA gene KW - pbrB gene KW - pbrC gene KW - pbrD gene KW - pbrT gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Adenosinetriphosphatase KW - Nucleotide sequence KW - Ralstonia metallidurans KW - Lead KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17907905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Cloning+and+Functional+Analysis+of+the+pbr+Lead+Resistance+Determinant+of+Ralstonia+metallidurans+CH34&rft.au=Borremans%2C+B%3BHobman%2C+J+L%3BProvoost%2C+A%3BBrown%2C+N+L%3Bvan+der+Lelie%2C+D&rft.aulast=Borremans&rft.aufirst=B&rft.date=2001-10-01&rft.volume=183&rft.issue=19&rft.spage=5651&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.183.19.5651-5658.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ralstonia metallidurans; Lead; Adenosinetriphosphatase; Nucleotide sequence DO - http://dx.doi.org/10.1128/JB.183.19.5651-5658.2001 ER - TY - JOUR T1 - Intercomparison of results for a PWR rod ejection accident AN - 18128389; 5224081 AB - This study is part of an overall program to understand the uncertainty in best-estimate calculations of the local fuel enthalpy during the rod ejection accident. Local fuel enthalpy is used as the acceptance criterion for this design-basis event and can also be used to estimate fuel damage for the purpose of determining radiological consequences. The study used results from neutron kinetics models in PARCS, BARS, and CRONOS2, codes developed in the United States, the Russian Federation, and France, respectively. Since BARS uses a heterogeneous representation of the fuel assembly as opposed to the homogeneous representations in PARCS and CRONOS, the effect of the intercomparison was primarily to compare different intra-assembly models. Quantitative comparisons for core power, reactivity, assembly fuel enthalpy and pin power were carried out. In general, the agreement between methods was very good, providing additional confidence in the codes and providing a starting point for a quantitative assessment of the uncertainty in calculated fuel enthalpy using best-estimate methods. JF - Nuclear Engineering and Design AU - Diamond, D J AU - Aronson, A AU - Jo, J AU - Avvakumov, A AU - Malofeev, V AU - Sidorov, V AU - Ferraresi, P AU - Gouin, C AU - Aniel, S AU - Royer, ME AD - Brookhaven National Laboratory, Nuclear Energy and Infrastructure Systems Divison, Energy Sciences and Technology Department, Building 130, P.O. Box 5000, Upton, NY 11973-5000, USA, diamond@bnl.gov Y1 - 2001/09// PY - 2001 DA - Sep 2001 SP - 181 EP - 189 VL - 208 IS - 2 SN - 0029-5493, 0029-5493 KW - fuel enthalpy KW - fuel rods KW - pressurized water reactors KW - rod ejection KW - Health & Safety Science Abstracts KW - Accidents KW - Nuclear reactors KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18128389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Engineering+and+Design&rft.atitle=Intercomparison+of+results+for+a+PWR+rod+ejection+accident&rft.au=Diamond%2C+D+J%3BAronson%2C+A%3BJo%2C+J%3BAvvakumov%2C+A%3BMalofeev%2C+V%3BSidorov%2C+V%3BFerraresi%2C+P%3BGouin%2C+C%3BAniel%2C+S%3BRoyer%2C+ME&rft.aulast=Diamond&rft.aufirst=D&rft.date=2001-09-01&rft.volume=208&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Nuclear+Engineering+and+Design&rft.issn=00295493&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Nuclear reactors; Accidents ER - TY - JOUR T1 - Addiction changes orbitofrontal gyrus function: Involvement in response inhibition AN - 18185037; 5199245 AB - We used the Stroop task as a measure of the ability to inhibit a prepotent response tendency and examined its association with relative glucose metabolism in selected prefrontal brain regions in cocaine addicts, alcoholics, and controls (17 per group). Results revealed that for the substance abusers, higher orbitofrontal gyrus (OFG) activation was associated with lower conflict (higher score; r = 0.32, p < 0.05). For the controls, higher OFG activation was associated with higher conflict (lower score; r = -0.42, p < 0.05). Thus, at baseline, increased relative activation of the OFG is associated with worse performance in controls and better performance in substance abusers on the Stroop task, suggesting reversal of the role of the OFG as a function of addiction. JF - Neuroreport AU - Goldstein, R Z AU - Volkow, N D AU - Wang, G-J AU - Fowler, J S AU - Rajaram, S AD - Brookhaven National Laboratory, Medical Research, Bldg. 490, 30 Bell Ave, Upton, NY 11973, USA Y1 - 2001/08/08/ PY - 2001 DA - 2001 Aug 08 SP - 2595 EP - 2599 VL - 12 IS - 11 SN - 0959-4965, 0959-4965 KW - Stroop task KW - man KW - orbitofrontal gyrus KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Glucose metabolism KW - Drug addiction KW - Cocaine KW - Cortex (prefrontal) KW - X 24180:Social poisons & drug abuse KW - N3 11139:Toxicological and psychoactive drug correlates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18185037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroreport&rft.atitle=Addiction+changes+orbitofrontal+gyrus+function%3A+Involvement+in+response+inhibition&rft.au=Goldstein%2C+R+Z%3BVolkow%2C+N+D%3BWang%2C+G-J%3BFowler%2C+J+S%3BRajaram%2C+S&rft.aulast=Goldstein&rft.aufirst=R&rft.date=2001-08-08&rft.volume=12&rft.issue=11&rft.spage=2595&rft.isbn=&rft.btitle=&rft.title=Neuroreport&rft.issn=09594965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cocaine; Drug addiction; Glucose metabolism; Cortex (prefrontal) ER - TY - JOUR T1 - Pedogenic fractionation and bioavailability of uranium and thorium in naturally radioactive Spodosols AN - 52166261; 2002-000601 JF - Soil Science Society of America Journal AU - Morton, L S AU - Evans, C V AU - Harbottle, G AU - Estes, G O Y1 - 2001/08// PY - 2001 DA - August 2001 SP - 1197 EP - 1203 PB - Soil Science Society of America, Madison, WI VL - 65 IS - 4 SN - 0361-5995, 0361-5995 KW - United States KW - neutron activation analysis data KW - medical geology KW - isotopes KW - radioactivity KW - Th-232 KW - bioavailability KW - human ecology KW - New Hampshire KW - radioactive isotopes KW - gamma-ray spectra KW - oxides KW - Haplorthods KW - spectra KW - soils KW - Red Eagle Pond KW - pedogenesis KW - chemical analysis KW - Albany New Hampshire KW - Hurricane Mountain KW - background level KW - Spodosols KW - geochemical cycle KW - Conway New Hampshire KW - metals KW - thorium KW - risk assessment KW - uranium KW - U-238 KW - Carroll County New Hampshire KW - actinides KW - chemical fractionation KW - 02D:Isotope geochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52166261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+Science+Society+of+America+Journal&rft.atitle=Pedogenic+fractionation+and+bioavailability+of+uranium+and+thorium+in+naturally+radioactive+Spodosols&rft.au=Morton%2C+L+S%3BEvans%2C+C+V%3BHarbottle%2C+G%3BEstes%2C+G+O&rft.aulast=Morton&rft.aufirst=L&rft.date=2001-08-01&rft.volume=65&rft.issue=4&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Soil+Science+Society+of+America+Journal&rft.issn=03615995&rft_id=info:doi/ L2 - http://soil.scijournals.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 33 N1 - PubXState - WI N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - CODEN - SSSJD4 N1 - SubjectsTermNotLitGenreText - actinides; Albany New Hampshire; background level; bioavailability; Carroll County New Hampshire; chemical analysis; chemical fractionation; Conway New Hampshire; gamma-ray spectra; geochemical cycle; Haplorthods; human ecology; Hurricane Mountain; isotopes; medical geology; metals; neutron activation analysis data; New Hampshire; oxides; pedogenesis; radioactive isotopes; radioactivity; Red Eagle Pond; risk assessment; soils; spectra; Spodosols; Th-232; thorium; U-238; United States; uranium ER - TY - JOUR T1 - Biogeochemical changes in the sediments of Lake Cantara South, a saline lake in South Australia AN - 18564895; 5218714 AB - Biogeochemical studies were undertaken of a 65-cm long sediment core from Lake Cantara South, South Australia. super(14)C determinations indicated that the sediments had been deposited over 2000 years. Changes with sediment depth in the concentration or ratio of the following were determined: (i) total organic carbon, total carbonate (inorganic) carbon, total sulfur, total carbon, total inorganic and organic sulfur, atomic C/N, and sulfate/chloride; (ii) n-alkanes; (iii) a highly branched isoprenoid alkane, and (iv) steroids. Interpretation of the changes with sediment depth indicated the nature of changes that took place when the system changed from a protected marine lagoon to an isolated (athalassic) saline lake. This change took place about 1000 years ago. JF - Hydrobiologia AU - Wang, R L AU - Williams, W D AD - Biogeochemical Lab, Indiana University, Bloomington, IN 47405 and Department of Applied Science, 535A, Brookhaven National Laboratory, Upton, NY 11973, U.S.A., rlwang@bnl.gov Y1 - 2001/08// PY - 2001 DA - Aug 2001 SP - 17 EP - 24 PB - Kluwer Academic Publishers VL - 457 IS - 1-3 SN - 0018-8158, 0018-8158 KW - Australia, Cantara L. KW - ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Marine KW - Q2 02187:Geochemistry of sediments KW - SW 0880:Chemical processes KW - SW 0850:Lakes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18564895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrobiologia&rft.atitle=Biogeochemical+changes+in+the+sediments+of+Lake+Cantara+South%2C+a+saline+lake+in+South+Australia&rft.au=Wang%2C+R+L%3BWilliams%2C+W+D&rft.aulast=Wang&rft.aufirst=R&rft.date=2001-08-01&rft.volume=457&rft.issue=1-3&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Hydrobiologia&rft.issn=00188158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Marine ER - TY - JOUR T1 - Dredged material decontamination demonstration for the Port of New York/New Jersey AN - 19671633; 5205482 AB - Management of contaminated dredged material is a significant challenge in the Port of New York and New Jersey as a result of more stringent regional ocean placement regulations with escalating costs for upland placement. One component of an overall management plan can be the application of a decontamination technology followed by creation of a product suitable for beneficial use. This concept is the focus of a project now being carried out by the US Environmental Protection Agency, Region 2, the US Army Corps of Engineers, New York District, the US Department of Energy, Brookhaven National Laboratory, and regional university groups that have included Rensselaer Polytechnic Institute, Rutgers University, New Jersey Institute of Technology, and Stevens Institute of Technology. The project has progressed through phased testing of commercial technologies at the bench scale (15 liters) (Marcor, Metcalf & Eddy, Gas Technology Institute, Westinghouse Science & Technology, BioGenesis, International Technology, and BioSafe) and pilot-scale (1.5-500 m super(3)) (BioGenesis, Gas Technology Institute, and Westinghouse Science & Technology) levels. The technologies developed by Gas Technology Institute and BioGenesis are now going forward to commercial demonstration facilities that are intended to treat from 23 000 to 60 000 m super(3) of dredged material during their first operational period in 2001-2002. Beneficial use products are soils and cement. Treatment costs for the final commercial facilities are estimated at US$ 39 per m super(3). Selection of the technologies was made based on the effectiveness of the treatment process, evaluation of the possible beneficial use of the treated materials, and other factors. Major elements of the project are summarized here. JF - Journal of Hazardous Materials AU - Jones, K W AU - Feng, H AU - Stern, E A AU - Lodge, J AU - Clesceri, N L AD - Brookhaven National Laboratory, Upton, NY 11973-5000, USA, kwj@bnl.gov Y1 - 2001/07/30/ PY - 2001 DA - 2001 Jul 30 SP - 127 EP - 143 VL - 85 IS - 1-2 SN - 0304-3894, 0304-3894 KW - USA, New Jersey, New Jersey Harbor KW - USA, New York, New York Harbor KW - recycling KW - Toxicology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Pollution Abstracts KW - Dredge spoil KW - USA, New Jersey KW - Waste Management KW - Decontamination KW - Economic Aspects KW - ANW, USA, New York, New York Harbor KW - Beneficial Use KW - Recycling KW - Concrete KW - Spoil KW - Restoration KW - Soil KW - Water pollution treatment KW - Economics KW - Soils KW - Sediment Contamination KW - Pilot Plants KW - Testing Procedures KW - Sediment pollution KW - Cement KW - Waste utilization KW - Construction materials KW - Waste treatment KW - Spoil Disposal KW - Harbours KW - USA, New York KW - Soil pollution KW - Performance Evaluation KW - Energy KW - Oceans KW - Dredging KW - Harbors KW - ANW, USA, New Jersey, New Jersey Harbor KW - Technology KW - SW 3050:Ultimate disposal of wastes KW - SW 3070:Water quality control KW - X 24350:Industrial Chemicals KW - Q5 08522:Protective measures and control KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19671633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Dredged+material+decontamination+demonstration+for+the+Port+of+New+York%2FNew+Jersey&rft.au=Jones%2C+K+W%3BFeng%2C+H%3BStern%2C+E+A%3BLodge%2C+J%3BClesceri%2C+N+L&rft.aulast=Jones&rft.aufirst=K&rft.date=2001-07-30&rft.volume=85&rft.issue=1-2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-08-01 N1 - SuppNotes - Special issue: Contaminated dredged soils. N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Sediment pollution; Dredge spoil; Waste utilization; Water pollution treatment; Soils; Economics; Construction materials; Dredging; Concrete; Harbours; Restoration; Spoil; Soil pollution; Soil; Cement; Oceans; Energy; Decontamination; Waste treatment; Recycling; Harbors; Testing Procedures; Performance Evaluation; Waste Management; Sediment Contamination; Economic Aspects; Beneficial Use; Pilot Plants; Spoil Disposal; Technology; USA, New Jersey; ANW, USA, New York, New York Harbor; USA, New York; ANW, USA, New Jersey, New Jersey Harbor ER - TY - JOUR T1 - Biologic responses to low doses of ionizing radiation: detriment versus hormesis. Part 1. Dose responses of cells and tissues. AN - 71013029; 11441881 JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Feinendegen, L E AU - Pollycove, M AD - Brookhaven National Laboratory, Brookhaven, New York, USA. Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 17N EP - 27N VL - 42 IS - 7 SN - 0161-5505, 0161-5505 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Animals KW - Relative Biological Effectiveness KW - Radiation Protection KW - Neoplasms, Radiation-Induced -- physiopathology KW - Radiation Injuries -- prevention & control KW - Humans KW - Adaptation, Physiological KW - DNA Damage -- radiation effects KW - Linear Energy Transfer KW - Radiation Injuries -- etiology KW - Dose-Response Relationship, Radiation KW - Cells -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71013029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Biologic+responses+to+low+doses+of+ionizing+radiation%3A+detriment+versus+hormesis.+Part+1.+Dose+responses+of+cells+and+tissues.&rft.au=Feinendegen%2C+L+E%3BPollycove%2C+M&rft.aulast=Feinendegen&rft.aufirst=L&rft.date=2001-07-01&rft.volume=42&rft.issue=7&rft.spage=17N&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-26 N1 - Date created - 2001-07-06 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: J Nucl Med. 2003 Jan;44(1):125; author reply 125-6 [12515886] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Scab incidence on pig skin resulting from hot particle exposures under varying conditions. AN - 70932011; 11414624 AB - External irradiations of pig skin using radioactive sources of less than 600 microm in the largest dimension (hot particles) were carried out. The objective of the study was to determine a threshold for scab induction. Hot particles used included fissioned 235U and activated 170Tm, 17SYb, and 46Sc with maximum beta-particle energies of approximately 1.8 (average), 0.97, 0.47, and 0.35 MeV, respectively. The photon emissions from the fissioned 235U were about 1 MeV per disintegration. The photon emissions from 46Sc were 0.89 and 1.12 MeV, with 100% abundance. Photon emissions from 170Tm and 175Yb were negligible. Responses followed cumulative normal probability distributions; thus, no true thresholds could be determined. Hence, 10% and 50% scab incidence rates (ED10 and ED50, respectively) were determined using probit analysis. For dose averaged over 1 cm2 at a depth of 70 microm, the ED10 (and 95% confidence limits) were 5.1 (2.7-7.2) Gy for 46Sc, 1.3 (0.89-1.8) Gy for 175Yb, 2.8 (1.9-3.5) Gy for 170Tm, 8.5 (5.7-9.8) Gy for on-skin fissioned UC2, and 4.5 (0.9-7.2) Gy for off-skin fissioned UC2. The ED50 values were 12 (8.8-17) Gy for 46Sc, 6.0 (4.3-9.7) Gy for 175Yb, 5.9 (5.1-6.7) Gy for 170Tm, 11 (9.9-19) Gy for on-skin fissioned 235UC2, and 11 (6.2-14) Gy for off-skin fissioned 235UC2. JF - Health physics AU - Kaurin, D G AU - Baum, J W AU - Carsten, A L AU - Schaefer, C W AD - Department of Advanced Technology, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. darryl.kaurin@mcmail.vanderbilt.edu Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 47 EP - 56 VL - 81 IS - 1 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Swine KW - Animals KW - Incidence KW - Dose-Response Relationship, Radiation KW - Skin -- radiation effects KW - Skin -- pathology KW - Radiation Injuries -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70932011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Scab+incidence+on+pig+skin+resulting+from+hot+particle+exposures+under+varying+conditions.&rft.au=Kaurin%2C+D+G%3BBaum%2C+J+W%3BCarsten%2C+A+L%3BSchaefer%2C+C+W&rft.aulast=Kaurin&rft.aufirst=D&rft.date=2001-07-01&rft.volume=81&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-05 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Scab diameters on pig skin resulting from hot particle exposures under varying conditions. AN - 70931962; 11414623 AB - The National Council on Radiation Protection and Measurements (NCRP) in NCRP Report Number 106 recommended a limit of 10(10) beta particles emitted from radioactive particles with sizes less than 1 mm (hot particles) to prevent acute deep ulceration. This recommendation was determined, in part, by regressing the diameter of the scabs induced by fissioned 235UC2 hot particles as a function of the logarithm of the number of beta particles emitted from the sources for one study. To validate this recommendation and the approach used by the NCRP, external irradiations of pig skin using radioactive sources of less than 600 microm in the largest dimension were carried out. The hot particles used included fissioned 235UC2 and activated 170Tm, 175Yb, and 46Sc. Results indicated a strong correlation between scab diameter and dose for scabs induced using fissioned 235UC2, activated 170Tm, and 46Sc, but not for 175Yb. The correlation value decreased with decreasing beta particle energy, with the exception of 46Sc, which had scabs with diameters greater than twice the maximum beta particle range. The larger scabs from 46Sc are thought to be due to dose contributions from the gamma rays. The results also give an ulceration threshold less than that given by NCRP to prevent acute deep ulceration. It was concluded that regression analysis of scab diameter as a function of either number of beta particles emitted from the hot particles or dose did not yield either precise or accurate thresholds but was useful in determining probable ranges of doses which lead to scab induction. JF - Health physics AU - Kaurin, D G AU - Baum, J W AU - Carsten, A L AU - Schaefer, C W AU - Forbes, P D AD - Department of Advanced Technology, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. darryl.kaurin@mcmail.vanderbilt.edu Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 35 EP - 46 VL - 81 IS - 1 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Swine KW - Animals KW - Gamma Rays KW - Dose-Response Relationship, Radiation KW - Skin -- radiation effects KW - Skin -- pathology KW - Radiation Injuries -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70931962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Scab+diameters+on+pig+skin+resulting+from+hot+particle+exposures+under+varying+conditions.&rft.au=Kaurin%2C+D+G%3BBaum%2C+J+W%3BCarsten%2C+A+L%3BSchaefer%2C+C+W%3BForbes%2C+P+D&rft.aulast=Kaurin&rft.aufirst=D&rft.date=2001-07-01&rft.volume=81&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-05 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - MucA protein affects spontaneous mutation in a localized region of Haemophilus influenzae. AN - 70931451; 11406171 AB - A plasmid called pMucA, from a piece of the plasmid pKM101 (Mol. Gen. Genet 167 (1979) 317) cloned in the vector pDM2 (J. Bacteriol. 151 (1982) 1605), caused higher mutation in a local region of Haemophilus influenzae and caused even more mutation there in a strain also containing novC, the latter causing an increase in supercoiling (J. Bacteriol 164 (1985) 525). The novD mutation depressed supercoiling, and also depressed the mutation by pMucA in the local region of the chromosome. Thus, it is clear that supercoiling is an important phenomenon in spontaneous mutation of H. influenzae. The pMucA plasmid caused a number of other phenomena in H. influenzae, induced UV mutation (Proc. Natl. Acad. Sci. USA 82 (1985) 7753), decreased UV sensitivity of transforming DNA, but not cells, and UV-induced recombination of mutants of phage HP1c1. The effect of the MucA protein in mutagenesis of H. influenzae we consider to be due to the introduction of some of the E. coli functions from pKM101. We postulate that the localized mutation caused by the MucA plasmid also involved localization of the plasmid or its coded protein in the same area, resulting from binding to a homologous gene, probably rec-1, very close to the localized region. JF - Mutation research AU - Setlow, J K AU - Haines, D AU - Cabrera-Juárez, E AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2001/07/01/ PY - 2001 DA - 2001 Jul 01 SP - 75 EP - 81 VL - 478 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - DNA, Superhelical KW - MucA protein, Bacteria KW - Novobiocin KW - 17EC19951N KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - Index Medicus KW - Genetic Linkage KW - Ultraviolet Rays KW - Plasmids -- genetics KW - DNA Topoisomerases, Type II -- genetics KW - Novobiocin -- pharmacology KW - Bacteriophages -- genetics KW - Drug Resistance, Microbial -- genetics KW - Chromosomes, Bacterial -- genetics KW - Dose-Response Relationship, Radiation KW - Recombination, Genetic -- radiation effects KW - Plasmids -- radiation effects KW - Chromosome Mapping KW - DNA, Superhelical -- genetics KW - Gene Order KW - Kanamycin Resistance -- genetics KW - Plasmids -- drug effects KW - Mutation KW - Bacteriophages -- radiation effects KW - Haemophilus influenzae -- radiation effects KW - Bacterial Proteins -- genetics KW - Haemophilus influenzae -- genetics KW - DNA, Bacterial -- genetics KW - Haemophilus influenzae -- drug effects KW - Bacterial Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70931451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=MucA+protein+affects+spontaneous+mutation+in+a+localized+region+of+Haemophilus+influenzae.&rft.au=Setlow%2C+J+K%3BHaines%2C+D%3BCabrera-Ju%C3%A1rez%2C+E&rft.aulast=Setlow&rft.aufirst=J&rft.date=2001-07-01&rft.volume=478&rft.issue=1-2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-06-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Gyrase mutants affect mutation in a localized region of Haemophilus influenzae. AN - 70920243; 11406172 AB - Spontaneous mutation was greatly increased in a localized region of the chromosome of Haemophilus influenzae, but not at other loci, by a nov gene mutation called novC that increased DNA supercoiling. Another nov gene mutation, called novD, decreased spontaneous mutation in the same localized region and depressed DNA supercoiling. Both mutations, which code for the gyrase B subunit, have been cloned, and the cloned versions also altered mutagenesis and supercoiling in a similar fashion as the two mutations on the chromosome, although novC on the plasmid caused somewhat less mutation than on the chromosome. We postulate that the effects of the gyrase B mutations on the chromosome result from their effects on supercoiling because of increased gyrase near its site of production. The fact that the novC on a plasmid does not cause mutagenesis except in the same localized region that is altered by this mutation on the chromosome, is difficult to explain. One possibility is that there is a complex of proteins in this region which is necessary for the effects on supercoiling and thus, also on mutagenesis. JF - Mutation research AU - Setlow, J K AU - Haines, D AU - Cabrera-Juárez, E AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2001/07/01/ PY - 2001 DA - 2001 Jul 01 SP - 83 EP - 88 VL - 478 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Proteins KW - DNA, Bacterial KW - DNA-Binding Proteins KW - rec-1 protein, Haemophilus influenzae KW - Novobiocin KW - 17EC19951N KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - Index Medicus KW - Genetic Linkage KW - Bacterial Proteins -- genetics KW - Gene Frequency KW - Novobiocin -- pharmacology KW - Drug Resistance, Microbial -- genetics KW - Anti-Bacterial Agents -- pharmacology KW - Chromosomes, Bacterial -- genetics KW - Mutation KW - Microbial Sensitivity Tests KW - Gene Order KW - Haemophilus influenzae -- genetics KW - DNA Topoisomerases, Type II -- genetics KW - DNA, Bacterial -- genetics KW - Haemophilus influenzae -- growth & development KW - Haemophilus influenzae -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70920243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Gyrase+mutants+affect+mutation+in+a+localized+region+of+Haemophilus+influenzae.&rft.au=Setlow%2C+J+K%3BHaines%2C+D%3BCabrera-Ju%C3%A1rez%2C+E&rft.aulast=Setlow&rft.aufirst=J&rft.date=2001-07-01&rft.volume=478&rft.issue=1-2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-06-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Frameshift Mutation in PRKDC, the Gene for DNA-PKcs, in the DNA Repair-Defective, Human, Glioma-Derived Cell Line M059J AN - 20034779; 8693207 AB - Anderson, C. W., Dunn, J. J., Freimuth, P. I., Galloway, A. M. and Allalunis-Turner, M. J. Frameshift Mutation in PRKDC, the Gene for DNA-PKcs, in the DNA Repair-Defective, Human, Glioma-Derived Cell Line M059J. Radiat. Res. 156, 2-9 (2001). The glioma-derived cell line M059J is hypersensitive to ionizing radiation, lacks DNA-PK activity, and fails to express protein for the catalytic subunit, DNA-PKcs, while a sister cell line, M059K, derived from the same tumor, has normal DNA-PK activity. Both cell lines are near pentaploid and have multiple copies of chromosome 8, the chromosome on which the DNA-PKcs gene, PRKDC, is located. Sequence analysis of PCR-amplified exons revealed the loss in M059J cells of a single 'A' nucleotide in exon 32, corresponding to the first nucleotide of codon 1351 (ACC, Thr) of PRKDC. Loss of the 'A' nucleotide would terminate the DNA-PKcs reading frame early in exon 33. DNA from M059K cells had only the wild-type sequence. An analysis of sequences surrounding PRKDC exon 32 from 87 unrelated individuals revealed no polymorphic nucleotides except for a triplet repeat near the 3' end of this exon; no individual had a frameshift mutation in exon 32. No other sequence differences in PRKDC between M059J and M059K cells were observed in similar to 15,000 bp of genomic sequence including the sequences of exons 5 through 38 and surrounding intron sequence, suggesting a possible reduction to homozygosity at this locus prior to acquisition of the mutation leading to the M059J cell line. JF - Radiation Research AU - Anderson, Carl W AU - Dunn, John J AU - Freimuth, Paul I AU - Galloway, Anne M AU - Joan Allalunis-Turner, M AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000, cwa@bnl.gov. Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 2 EP - 9 PB - Allen Press, Inc., 810 East Tenth St. VL - 156 IS - 1 SN - 0033-7587, 0033-7587 KW - Genetics Abstracts; Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Exons KW - Nucleotide sequence KW - DNA-PKc gene KW - Catalytic subunits KW - Tumors KW - Nucleotides KW - DNA-dependent protein kinase KW - chromosome 8 KW - Frameshift mutation KW - Ionizing radiation KW - Introns KW - DNA KW - Codons KW - Language KW - genomics KW - X 24390:Radioactive Materials KW - N 14815:Nucleotide Sequence KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20034779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Frameshift+Mutation+in+PRKDC%2C+the+Gene+for+DNA-PKcs%2C+in+the+DNA+Repair-Defective%2C+Human%2C+Glioma-Derived+Cell+Line+M059J&rft.au=Anderson%2C+Carl+W%3BDunn%2C+John+J%3BFreimuth%2C+Paul+I%3BGalloway%2C+Anne+M%3BJoan+Allalunis-Turner%2C+M&rft.aulast=Anderson&rft.aufirst=Carl&rft.date=2001-07-01&rft.volume=156&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2F0033-7587%282001%291562.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Exons; Nucleotide sequence; DNA-PKc gene; Catalytic subunits; Tumors; DNA-dependent protein kinase; Nucleotides; chromosome 8; Frameshift mutation; Ionizing radiation; Codons; DNA; Introns; Language; genomics DO - http://dx.doi.org/10.1667/0033-7587(2001)156[0002:FMIPTG]2.0.CO;2 ER - TY - JOUR T1 - [ super(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy AN - 17915138; 5152785 AB - Cocaine was initially labeled with carbon-11 in order to track the distribution and pharmacokinetics of this powerful stimulant and drug of abuse in the human brain and body. It was soon discovered that [ super(11)C]cocaine was not only useful for measuring cocaine pharmacokinetics and its relationship to behavior but that it is also a sensitive radiotracer for dopamine transporter (DAT) availability. Measures of DAT availability were facilitated by the development of a graphical analysis method (Logan Plot) for reversible systems which streamlined kinetic analysis. This expanded the applications of [ super(11)C]cocaine to studies of DAT availability in the human brain and allowed the first comparative measures of the degree of DAT occupancy by cocaine and another stimulant drug methylphenidate. This article will summarize preclinical and clinical research with [ super(11)C]cocaine. JF - Nuclear Medicine and Biology AU - Fowler, J S AU - Volkow, N D AU - Wang, G-J AU - Gatley, S J AU - Logan, J AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA, fowler@bnl.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 561 EP - 572 VL - 28 IS - 5 SN - 0969-8051, 0969-8051 KW - pharmacokinetics KW - Toxicology Abstracts KW - Dopamine transporter KW - Reviews KW - Positron emission tomography KW - Cocaine KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17915138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Medicine+and+Biology&rft.atitle=%5B+super%2811%29%5DCocaine%3A+PET+studies+of+cocaine+pharmacokinetics%2C+dopamine+transporter+availability+and+dopamine+transporter+occupancy&rft.au=Fowler%2C+J+S%3BVolkow%2C+N+D%3BWang%2C+G-J%3BGatley%2C+S+J%3BLogan%2C+J&rft.aulast=Fowler&rft.aufirst=J&rft.date=2001-07-01&rft.volume=28&rft.issue=5&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Nuclear+Medicine+and+Biology&rft.issn=09698051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Dopamine transporter; Cocaine; Positron emission tomography; Reviews ER - TY - JOUR T1 - Engineering delta 9-16:0-acyl carrier protein (ACP) desaturase specificity based on combinatorial saturation mutagenesis and logical redesign of the castor delta 9-18:0-ACP desaturase. AN - 70941560; 11294879 AB - Six amino acid locations in the soluble castor Delta(9)-18:0-acyl carrier protein (ACP) desaturase were identified that can affect substrate specificity. Combinatorial saturation mutagenesis of these six amino acids, in conjunction with selection, using an unsaturated fatty acid auxotroph system, led to the isolation of variants with up to 15-fold increased specific activity toward 16-carbon substrates. The most improved mutant, com2, contained two substitutions (T117R/G188L) common to five of the 19 complementing variants subjected to further analysis. These changes, when engineered into otherwise wild-type 18:0-ACP desaturase to make mutant 5.2, produced a 35-fold increase in specific activity with respect to 16-carbon substrates. Kinetic analysis revealed changes in both k(cat) and K(m) that result in an 82-fold improvement in specificity factor for 16-carbon substrate compared with wild-type enzyme. Improved substrate orientation apparently compensated for loss of binding energy that results from the loss of desolvation energy for 16-carbon substrates. Mutant 5.2 had specific activity for 16-carbon substrates 2 orders of magnitude higher than those of known natural 16-carbon specific desaturases. These data support the hypothesis that it should be possible to reengineer archetypal enzymes to achieve substrate specificities characteristic of recently evolved enzymes while retaining the desired stability and/or turnover characteristics of a parental paralog. JF - The Journal of biological chemistry AU - Whittle, E AU - Shanklin, J AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2001/06/15/ PY - 2001 DA - 2001 Jun 15 SP - 21500 EP - 21505 VL - 276 IS - 24 SN - 0021-9258, 0021-9258 KW - DNA Primers KW - 0 KW - Fatty Acids KW - Recombinant Proteins KW - Mixed Function Oxygenases KW - EC 1.- KW - acyl-(acyl-carrier-protein)desaturase KW - EC 1.14.19.2 KW - Index Medicus KW - Genetic Variation KW - Protein Structure, Secondary KW - Models, Molecular KW - Combinatorial Chemistry Techniques KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - Fatty Acids -- metabolism KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Point Mutation KW - Fatty Acids -- chemistry KW - Genetic Complementation Test KW - Substrate Specificity KW - Recombinant Proteins -- chemistry KW - Amino Acid Substitution KW - Plants, Toxic KW - Mixed Function Oxygenases -- chemistry KW - Mixed Function Oxygenases -- metabolism KW - Castor Bean -- enzymology KW - Mixed Function Oxygenases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70941560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Engineering+delta+9-16%3A0-acyl+carrier+protein+%28ACP%29+desaturase+specificity+based+on+combinatorial+saturation+mutagenesis+and+logical+redesign+of+the+castor+delta+9-18%3A0-ACP+desaturase.&rft.au=Whittle%2C+E%3BShanklin%2C+J&rft.aulast=Whittle&rft.aufirst=E&rft.date=2001-06-15&rft.volume=276&rft.issue=24&rft.spage=21500&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-19 N1 - Date created - 2001-06-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Human cancer: etiologic agents/dose responses/DNA repair/cellular and animal models. AN - 70882089; 11376681 AB - The observation of cancer in an individual does not identify the causative agent(s). However, epidemiological data on populations do indicate that a large fraction of human cancers are associated with lifestyle/diet. Such studies may also help identify the etiologic agents but unless there are good dose-response data for humans and/or animal models, the probability of identifying the agent is not high. Cancers may result from endogenous reactions, such as oxidations or from exogenous agents, such as tobacco smoke (lung cancer), sunlight exposure (skin cancer), aflatoxin (liver cancer), and relatively high doses of ionizing radiations (many types of cancers). Many carcinogenic chemicals have been identified in the workplace but, they usually do not affect the overall population. Most cancer causing agents affect cellular DNA and change its coding specificity and act as cancer initiators. The repair of DNA damage ameliorates most of these endogenous and exogenous changes. The important role of DNA repair in controlling the induction of human cancer came from the observation that individuals with the skin cancer-susceptible, human disease xeroderma pigmentosum (XP) were defective in nucleotide excision repair. Endogenous DNA damages are usually damages to individual bases and are usually repaired by systems of glycosylases and endonucleases. It should be useful to investigate the rates of appearance of tumors in normal mice and in mice knocked out for specific repair enzymes because such mice could be used to test the roles of diet and caloric input in affecting particular types of endogenous damages. JF - Mutation research AU - Setlow, R B AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. setlow@bnl.gov Y1 - 2001/06/02/ PY - 2001 DA - 2001 Jun 02 SP - 1 EP - 6 VL - 477 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - Carcinogens, Environmental KW - Index Medicus KW - Space life sciences KW - Non-programmatic KW - Animals KW - DNA Repair KW - Dose-Response Relationship, Drug KW - Humans KW - Energy Intake KW - Disease Models, Animal KW - Diet KW - Carcinogens, Environmental -- toxicity KW - Mutation KW - Neoplasms -- drug therapy KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70882089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Human+cancer%3A+etiologic+agents%2Fdose+responses%2FDNA+repair%2Fcellular+and+animal+models.&rft.au=Setlow%2C+R+B&rft.aulast=Setlow&rft.aufirst=R&rft.date=2001-06-02&rft.volume=477&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-19 N1 - Date created - 2001-05-29 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Three unique experimental fish stories: Poecilia (the Past), Xiphophorus (the Present), and Medaka (the Future). AN - 71385218; 14961296 AB - These three stories exemplify the uniqueness of fish models in their abilities to answer important biological questions. The first one identifies the major UV-induced damage (pyrimidine dimers) that is responsible for tumor induction. Thyroid cells from isogenic fish ( Poecilia formosa) were exposed to UV in vitro, then either exposed or not to photoreactivating light that monomerizes dimers, and the cells were injected into isogenic recipients. In the absence of photoreactivating light, the recipients developed tumors; in its presence, there were very few tumors. The second story describes our use of backcross hybrids of Xiphophorus as a model for melanoma induction by several UV and visible wavelengths. All the wavelengths were effective. (Squamous cell carcinomas in mice are induced preferentially by wavelengths <320 nm.) The data strongly suggest that light absorbed by the black pigment melanin damages DNA. The third story is designed to determine the mutagenic effects on sperm of the high atomic number, high-energy (HZE) nuclei present in cosmic rays by measuring mutations in progeny of exposed male medaka. JF - Marine biotechnology (New York, N.Y.) AU - Setlow, R B AU - Woodhead, A D AD - Biology Department, Brookhaven National Laboratory, Upton NY 11973, USA. setlow@bnl.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - S17 EP - S23 VL - 3 SN - 1436-2228, 1436-2228 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71385218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+biotechnology+%28New+York%2C+N.Y.%29&rft.atitle=Three+unique+experimental+fish+stories%3A+Poecilia+%28the+Past%29%2C+Xiphophorus+%28the+Present%29%2C+and+Medaka+%28the+Future%29.&rft.au=Setlow%2C+R+B%3BWoodhead%2C+A+D&rft.aulast=Setlow&rft.aufirst=R&rft.date=2001-06-01&rft.volume=3&rft.issue=&rft.spage=S17&rft.isbn=&rft.btitle=&rft.title=Marine+biotechnology+%28New+York%2C+N.Y.%29&rft.issn=14362228&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-26 N1 - Date created - 2004-02-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Multilayer Protection Analysis for Photovoltaic Manufacturing Facilities AN - 18086293; 5176099 AB - This paper gives an overview of environmental health and safety (EHS) issues related to photovoltaic (PV) technologies, and strategies for reducing EHS risks. These strategies include layers of prevention and mitigation in six sequential steps. Prevention layers are related to safer technologies, processes, and materials; safer use of materials; preventing accident-initiating events; preventing or minimizing releases, and preventing human exposures. The mitigation options include secondary confinement, emergency scrubbers, and adsorption units. As the PV industry approaches these issues and mitigation strategies in a vigilant, systematic way, the risk to industry, workers, and the public will be minimized. JF - Process Safety Progress AU - Fthenakis, V M AD - Environmental Research & Technology Division, Environmental Sciences Dept., Brookhaven National Laboratory, Upton, NT 11973, USA Y1 - 2001/06// PY - 2001 DA - Jun 2001 VL - 20 IS - 2 SN - 0278-4513, 0278-4513 KW - photovoltaics KW - Health & Safety Science Abstracts KW - Manufacturing industry KW - Accidents KW - Environmental health KW - Occupational exposure KW - Public health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18086293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Process+Safety+Progress&rft.atitle=Multilayer+Protection+Analysis+for+Photovoltaic+Manufacturing+Facilities&rft.au=Fthenakis%2C+V+M&rft.aulast=Fthenakis&rft.aufirst=V&rft.date=2001-06-01&rft.volume=20&rft.issue=2&rft.spage=P.+87&rft.isbn=&rft.btitle=&rft.title=Process+Safety+Progress&rft.issn=02784513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational exposure; Accidents; Manufacturing industry; Environmental health; Public health ER - TY - JOUR T1 - Response of avian embryonic brain to spatially segmented X-ray microbeams AN - 17902999; 5166407 AB - Duck embryo was studied as a model for assessing the effects of microbeam radiation therapy (MRT) on the human infant brain. Because of the high risk of radiation-induced disruption of the developmental process in the immature brain, conventional wide-beam radiotherapy of brain tumors is seldom carried out in infants under the age of three. Other types of treatment for pediatric brain tumors are frequently ineffective. Recent findings from studies in Grenoble on the brain of suckling rats indicate that MRT could be of benefit for the treatment of early childhood tumors. In our studies, duck embryos were irradiated at 3-4 days prior to hatching. Irradiation was carried out using a single exposure of synchrotron-generated X-rays, either in the form of parallel microplanar beams (microbeams), or as non-segmented broad beam. The individual microplanar beams had a width of 27 mu m and height of 11 mm, and a center-to-center spacing of 100 mu m. Doses to the exposed areas of embryo brain were 40, 80, 160 and 450 Gy (in-slice dose) for the microbeam, and 6, 12 and 18 Gy for the broad beam. The biological end point employed in the study was ataxia. This neurological symptom of radiation damage to the brain developed within 75 days of hatching. Histopathological analysis of brain tissue did not reveal any radiation induced lesions for microbeam doses of 40-160 Gy (in-slice), although some incidences of ataxia were observed in that dose group. However, severe brain lesions did occur in animals in the 450 Gy microbeam dose groups, and mild lesions in the 18 Gy broad beam dose group. These results indicate that embryonic duck brain has an appreciably higher tolerance to the microbeam modality, as compared to the broad beam modality. When the microbeam dose was normalized to the full volume of the irradiated tissue, i.e., the dose averaged over microbeams and the space between the microbeams, brain tolerance was estimated to be about three times higher to microbeam irradiation as compared with broad beam irradiation. JF - Cellular and Molecular Biology AU - Dilmanian, F A AU - Morris, G M AU - Le Duc, G AU - Huang, X AU - Ren, B AU - Bacarian, T AU - Allen, J C AU - Kalef-Fzra, J AU - Orion, I AU - Rosen, E M AU - Sandhu, T AU - Sathe, P AU - Wu, X Y AU - Zhong, Z AU - Shivaprasad, H L AD - Medical Department, Bldg. 490, Brookhaven National Laboratory, Upton NY 11973-5000, USA, dilmanian@bnl.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 485 EP - 493 VL - 47 IS - 3 SN - 0145-5680, 0145-5680 KW - microbeam radiation therapys KW - Birds KW - ducks KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - X radiation KW - Brain KW - Aves KW - Radiation KW - Ataxia KW - Embryos KW - Infants KW - N3 11104:Mammals (except primates) KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17902999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Biology&rft.atitle=Response+of+avian+embryonic+brain+to+spatially+segmented+X-ray+microbeams&rft.au=Dilmanian%2C+F+A%3BMorris%2C+G+M%3BLe+Duc%2C+G%3BHuang%2C+X%3BRen%2C+B%3BBacarian%2C+T%3BAllen%2C+J+C%3BKalef-Fzra%2C+J%3BOrion%2C+I%3BRosen%2C+E+M%3BSandhu%2C+T%3BSathe%2C+P%3BWu%2C+X+Y%3BZhong%2C+Z%3BShivaprasad%2C+H+L&rft.aulast=Dilmanian&rft.aufirst=F&rft.date=2001-05-01&rft.volume=47&rft.issue=3&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Biology&rft.issn=01455680&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Special Issue: Biological Evaluation of Irradiation Consequences. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aves; Embryos; Brain; X radiation; Radiation; Infants; Ataxia ER - TY - JOUR T1 - Binding of antigenic peptide to the endoplasmic reticulum-resident protein gp96/GRP94 heat shock chaperone occurs in higher order complexes. Essential role of some aromatic amino acid residues in the peptide-binding site. AN - 77020708; 11148208 AB - Vaccination with heat shock protein gp96-antigenic peptide complexes produces a powerful specific immune response against cancers and infectious diseases in some experimental animal models, and gp96-peptide complexes are now being tested in human clinical trials. gp96 appears to serve as a natural adjuvant for chaperoning antigenic peptides into the immune surveillance pathways. A fundamental issue that needs to be addressed is the mechanism of binding of antigenic peptide to gp96. Here, we show using scanning transmission electron microscopy that recombinant gp96 binds peptide in stable multimeric complexes, which may have biological significance. To open the possibility for genetically engineering gp96 for improved immunogenicity and to understand if molecular recognition plays a role in the binding of antigenic peptide, we mutagenized some specific aromatic amino acids in the presumed peptide-binding pocket. Replacement of Tyr-667 or Tyr-678 to Ala reduced affinity for peptide whereas conversion of Trp-654 to Tyr increased peptide binding. Similarly, changing Trp-621 to Phe or Leu or Ala or Ile negatively affected peptide binding whereas changing Trp-621 to Tyr or Val positively affected peptide binding. Probing the peptide microenvironment in gp96-peptide complexes, suggested that hydrophobic interactions (and perhaps hydrogen bonding/stacking interactions) may play a role in peptide loading by gp96. JF - The Journal of biological chemistry AU - Linderoth, N A AU - Simon, M N AU - Hainfeld, J F AU - Sastry, S AD - Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021 and the Department of Biology, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 2001/04/06/ PY - 2001 DA - 2001 Apr 06 SP - 11049 EP - 11054 VL - 276 IS - 14 SN - 0021-9258, 0021-9258 KW - Antigens, Neoplasm KW - 0 KW - Antigens, Surface KW - Heat-Shock Proteins KW - Peptides KW - Recombinant Proteins KW - sarcoma glycoprotein gp96 rejection antigens KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Antigens, Surface -- ultrastructure KW - Humans KW - Peptides -- metabolism KW - Heat-Shock Proteins -- ultrastructure KW - Protein Binding KW - Recombinant Proteins -- metabolism KW - Recombinant Proteins -- ultrastructure KW - Escherichia coli KW - Antigens, Surface -- metabolism KW - Peptides -- genetics KW - Mutation KW - Microscopy, Electron, Scanning KW - Endoplasmic Reticulum -- metabolism KW - Antigens, Neoplasm -- ultrastructure KW - Antigens, Neoplasm -- metabolism KW - Endoplasmic Reticulum -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77020708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Binding+of+antigenic+peptide+to+the+endoplasmic+reticulum-resident+protein+gp96%2FGRP94+heat+shock+chaperone+occurs+in+higher+order+complexes.+Essential+role+of+some+aromatic+amino+acid+residues+in+the+peptide-binding+site.&rft.au=Linderoth%2C+N+A%3BSimon%2C+M+N%3BHainfeld%2C+J+F%3BSastry%2C+S&rft.aulast=Linderoth&rft.aufirst=N&rft.date=2001-04-06&rft.volume=276&rft.issue=14&rft.spage=11049&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2001-04-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Old stones, new science AN - 52206444; 2001-056700 JF - Journal of Radioanalytical and Nuclear Chemistry AU - Holmes, L L AU - Harbottle, G AU - Blanc, Annie A2 - Filby, Roy H. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 75 EP - 79 PB - Kluwer Academic Publishers and Akademiai Kiado, Dordrecht - Budapest VL - 248 IS - 1 SN - 0236-5731, 0236-5731 KW - limestone KW - neutron activation analysis data KW - Sens France KW - limestone deposits KW - Europe KW - Holocene KW - Burgundy KW - artifacts KW - France KW - Cenozoic KW - sedimentary rocks KW - museums KW - multivariate analysis KW - cathedrals KW - applications KW - geochemistry KW - collections KW - archaeology KW - Western Europe KW - Quaternary KW - Ile-de-France France KW - quarries KW - art KW - statistical analysis KW - Amiens France KW - Picardy KW - provenance KW - Middle Ages KW - Normandy KW - Dordogne France KW - carbonate rocks KW - Seine Valley KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52206444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Radioanalytical+and+Nuclear+Chemistry&rft.atitle=Old+stones%2C+new+science&rft.au=Holmes%2C+L+L%3BHarbottle%2C+G%3BBlanc%2C+Annie&rft.aulast=Holmes&rft.aufirst=L&rft.date=2001-04-01&rft.volume=248&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+Radioanalytical+and+Nuclear+Chemistry&rft.issn=02365731&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - MARC V ; Fifth international conference on Methods and applications of radioanalytical chemistry N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 13 N1 - Document feature - illus. incl. sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - JRNCDM N1 - SubjectsTermNotLitGenreText - Amiens France; applications; archaeology; art; artifacts; Burgundy; carbonate rocks; cathedrals; Cenozoic; collections; Dordogne France; Europe; France; geochemistry; Holocene; Ile-de-France France; limestone; limestone deposits; Middle Ages; multivariate analysis; museums; neutron activation analysis data; Normandy; Picardy; provenance; quarries; Quaternary; sedimentary rocks; Seine Valley; Sens France; statistical analysis; Western Europe ER - TY - JOUR T1 - Crown carbon gain and elevated [CO sub(2)] responses of understorey saplings with differing allometry and architecture AN - 18249270; 5307605 AB - Attempts at determining the physiological basis of species' differences, such as the ability to grow in deep shade, have been of limited success. However, this basis is fundamental to predicting species' responses to rising atmospheric CO sub(2) in the forest understorey. We linked a leaf photosynthesis and a tree architecture model to predict the effects of dynamic and steady state photosynthetic characteristics, crown architecture and elevated atmospheric CO sub(2) concentration ([CO sub(2)]) on crown-level carbon gain (A sub(crown)). Twenty-four-h A sub(crown) was modelled for shade-tolerant Acer rubrum and shade-intolerant Liriodendron tulipifera saplings growing for three years in a forest understorey under ambient and elevated [CO sub(2)] in free-air CO sub(2) enrichment. Two factors best explained A sub(crown) in ambient [CO sub(2)]: tree light environment and sapling allometry. Microsite light environment influenced carbon gain via daily photosynthetic photon flux (PFD), average diffuse PFD and sunfleck characteristics. Species differences in specific leaf area (SLA) and size-related biomass allocation to leaves affected the effective leaf area and hence A sub(crown). At a common above-ground biomass, small saplings (100 g above-ground dry mass) of L. tulipifera had higher A sub(crown) than A. rubrum samples due to larger SLA and greater biomass allocation to leaves. Larger saplings of the two species had similar A sub(crown) due to greater carbon allocation to leaves with increasing plant size in A. rubrum vs L. tulipifera. For saplings > 800 g, A sub(crown) was greater in A. rubrum than in L. tulipifera. Enhancement of A sub(crown) by elevated [CO sub(2)] on sunny days was similar for both species. Overall, though the shade-tolerant species had lower A sub(crown) than the shade-intolerant species at a common small size, our results indicate that the relative performance of these species can reverse at larger sizes due to allocational differences. These results suggest that elevated [CO sub(2)] may accelerate competition for light between A. rubrum and L. tulipifera as these species grow larger in the understorey. JF - Functional Ecology AU - Naumburg, E AU - Ellsworth, D S AU - Pearcy, R W AD - Nicholas School of the Environment, Duke University, Durham, NC 27708-0328, USA, Department of Environmental Sciences, Brookhaven National Laboratory, Upton, NY 11973-5000, USA, and Division of Biological Sciences, Section of Ecology and Evolution, University of California at Davis, CA 95616, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 263 EP - 273 PB - Blackwell Science Ltd VL - 15 IS - 2 SN - 0269-8463, 0269-8463 KW - Tulip poplar KW - Red maple KW - Ecology Abstracts KW - Photosynthesis KW - Liriodendron tulipifera KW - Shade KW - Climatic changes KW - Allometry KW - Carbon dioxide KW - Acer rubrum KW - Atmospheric conditions KW - Models KW - D 04003:Modeling, mathematics, computer applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18249270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Functional+Ecology&rft.atitle=Crown+carbon+gain+and+elevated+%5BCO+sub%282%29%5D+responses+of+understorey+saplings+with+differing+allometry+and+architecture&rft.au=Naumburg%2C+E%3BEllsworth%2C+D+S%3BPearcy%2C+R+W&rft.aulast=Naumburg&rft.aufirst=E&rft.date=2001-04-01&rft.volume=15&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Functional+Ecology&rft.issn=02698463&rft_id=info:doi/10.1046%2Fj.1365-2435.2001.00518.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Liriodendron tulipifera; Acer rubrum; Atmospheric conditions; Allometry; Models; Carbon dioxide; Shade; Photosynthesis; Climatic changes DO - http://dx.doi.org/10.1046/j.1365-2435.2001.00518.x ER - TY - JOUR T1 - A strategy for removing the bias in the graphical analysis method. AN - 85272987; pmid-11295885 AB - The graphical analysis method, which transforms multiple time measurements of plasma and tissue uptake data into a linear plot, is a useful tool for rapidly obtaining information about the binding of radioligands used in PET studies. The strength of the method is that it does not require a particular model structure. However, a bias is introduced in the case of noisy data resulting in the underestimation of the distribution volume (DV), the slope obtained from the graphical method. To remove the bias, a modification of the method developed by Feng et al. (1993), the generalized linear least squares (GLLS) method, which provides unbiased estimates for compartment models was used. The one compartment GLLS method has a relatively simple form, which was used to estimate the DV directly and as a smoothing technique for more general classes of model structures. In the latter case, the GLLS method was applied to the data in two parts, that is, one set of parameters was determined for times 0 to T1 and a second set from T1 to the end time. The curve generated from these two sets of parameters then was used as input to the graphical method. This has been tested using simulations of data similar to that of the PET ligand [11C]-d-threo-methylphenidate (MP, DV = 35 mL/mL) and 11C raclopride (RAC, DV = 1.92 mL/mL) and compared with two examples from image data with the same tracers. The noise model was based on counting statistics through the half-life of the isotope and the scanning time. Five hundred data sets at each noise level were analyzed. Results (DV) for the graphical analysis (DV(G)), the nonlinear least squares (NLS) method (DV(NLS)), the one-tissue compartment GLLS method (DV(F)), and the two part GLLS followed by graphical analysis (DV(FG)) were compared. DV(FG) was found to increase somewhat with increasing noise and in some data sets at high noise levels no estimate could be obtained. However, at intermediate levels it provided a good estimation of the true DV. This method was extended to use a reference tissue in place of the input function to generate the distribution volume ratio (DVR) to the reference region. A linearized form of the simplified reference tissue method of Lammertsma and Hume (1996) was used. The DVR generated directly from the model (DVR(FL)) was compared with DVR(FG) (determined from a "smoothed" uptake curve as for DV(FG)) using the graphical method. JF - Journal of Cerebral Blood Flow and Metabolism AU - Logan, J AU - Fowler, J S AU - Volkow, N D AU - Ding, Y S AU - Wang, G J AU - Alexoff, D L AD - Chemistry and Medical Departments, Brookhaven National Laboratory, Upton, New York 11973, USA. PY - 2001 SP - 307 EP - 320 VL - 21 IS - 3 SN - 0271-678X, 0271-678X KW - Carbon Radioisotopes KW - Support, U.S. Gov't, P.H.S. KW - Artifacts KW - Human KW - Methylphenidate KW - Dopamine Antagonists KW - Basal Ganglia KW - Kinetics KW - Fluorine Radioisotopes KW - Raclopride KW - Support, Non-U.S. Gov't KW - Tomography, Emission-Computed KW - Support, U.S. Gov't, Non-P.H.S. KW - Dopamine Agents KW - Models, Cardiovascular KW - Cerebrovascular Circulation KW - Bias (Epidemiology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85272987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.atitle=A+strategy+for+removing+the+bias+in+the+graphical+analysis+method.&rft.au=Logan%2C+J%3BFowler%2C+J+S%3BVolkow%2C+N+D%3BDing%2C+Y+S%3BWang%2C+G+J%3BAlexoff%2C+D+L&rft.aulast=Logan&rft.aufirst=J&rft.date=2001-03-01&rft.volume=21&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.issn=0271678X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. AN - 76980917; 11229978 AB - OBJECTIVEMethamphetamine has raised concerns because it may be neurotoxic to the human brain. Although prior work has focused primarily on the effects of methamphetamine on dopamine cells, there is evidence that other neuronal types are affected. The authors measured regional brain glucose metabolism, which serves as a marker of brain function, to assess if there is evidence of functional changes in methamphetamine abusers in regions other than those innervated by dopamine cells.METHODFifteen detoxified methamphetamine abusers and 21 comparison subjects underwent positron emission tomography following administration of [(18)F]fluorodeoxyglucose.RESULTSWhole brain metabolism in the methamphetamine abusers was 14% higher than that of comparison subjects; the differences were most accentuated in the parietal cortex (20%). After normalization for whole brain metabolism, methamphetamine abusers exhibited significantly lower metabolism in the thalamus (17% difference) and striatum (where the differences were larger for the caudate [12%] than for the putamen [6%]). Statistical parametric mapping analyses corroborated these findings, revealing higher metabolism in the parietal cortex and lower metabolism in the thalamus and striatum of methamphetamine abusers.CONCLUSIONSThe fact that the parietal cortex is a region devoid of any significant dopaminergic innervation suggests that the higher metabolism seen in this region in the methamphetamine abusers is the result of methamphetamine effects in circuits other than those modulated by dopamine. In addition, the lower metabolism in the striatum and thalamus (major outputs of dopamine signals into the cortex) is likely to reflect the functional consequence of methamphetamine in dopaminergic circuits. These results provide evidence that, in humans, methamphetamine abuse results in changes in function of dopamine- and nondopamine-innervated brain regions. JF - The American journal of psychiatry AU - Volkow, N D AU - Chang, L AU - Wang, G J AU - Fowler, J S AU - Franceschi, D AU - Sedler, M J AU - Gatley, S J AU - Hitzemann, R AU - Ding, Y S AU - Wong, C AU - Logan, J AD - Department of Psychiatry, State University of New York at Stony Brook, USA. volkow@bnl.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 383 EP - 389 VL - 158 IS - 3 SN - 0002-953X, 0002-953X KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Methamphetamine KW - 44RAL3456C KW - Glucose KW - IY9XDZ35W2 KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Sex Factors KW - Corpus Striatum -- metabolism KW - Humans KW - Dopamine -- physiology KW - Dopamine -- metabolism KW - Thalamus -- drug effects KW - Corpus Striatum -- diagnostic imaging KW - Thalamus -- metabolism KW - Thalamus -- diagnostic imaging KW - Tomography, Emission-Computed -- statistics & numerical data KW - Adult KW - Corpus Striatum -- drug effects KW - Female KW - Male KW - Substance-Related Disorders -- physiopathology KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Methamphetamine -- metabolism KW - Methamphetamine -- adverse effects KW - Glucose -- metabolism KW - Brain -- drug effects KW - Methamphetamine -- pharmacology KW - Brain -- metabolism KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Cerebral Cortex -- diagnostic imaging KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76980917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Higher+cortical+and+lower+subcortical+metabolism+in+detoxified+methamphetamine+abusers.&rft.au=Volkow%2C+N+D%3BChang%2C+L%3BWang%2C+G+J%3BFowler%2C+J+S%3BFranceschi%2C+D%3BSedler%2C+M+J%3BGatley%2C+S+J%3BHitzemann%2C+R%3BDing%2C+Y+S%3BWong%2C+C%3BLogan%2C+J&rft.aulast=Volkow&rft.aufirst=N&rft.date=2001-03-01&rft.volume=158&rft.issue=3&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-03-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. AN - 76979341; 11229977 AB - OBJECTIVEMethamphetamine is a popular and highly addictive drug of abuse that has raised concerns because it has been shown in laboratory animals to be neurotoxic to dopamine terminals. The authors evaluated if similar changes occur in humans and assessed if they were functionally significant.METHODPositron emission tomography scans following administration of [(11)C]d-threo-methylphenidate (a dopamine transporter ligand) measured dopamine transporter levels (a marker of dopamine cell terminals) in the brains of 15 detoxified methamphetamine abusers and 18 comparison subjects. Neuropsychological tests were also performed to assess motor and cognitive function.RESULTSMethamphetamine abusers showed significant dopamine transporter reduction in the striatum (mean differences of 27.8% in the caudate and 21.1% in the putamen) relative to the comparison subjects; this reduction was evident even in abusers who had been detoxified for at least 11 months. Dopamine transporter reduction was associated with motor slowing and memory impairment.CONCLUSIONSThese results provide evidence that methamphetamine at dose levels taken by human abusers of the drug leads to dopamine transporter reduction that is associated with motor and cognitive impairment. These results emphasize the urgency of alerting clinicians and the public of the long-term changes that methamphetamine can induce in the human brain. JF - The American journal of psychiatry AU - Volkow, N D AU - Chang, L AU - Wang, G J AU - Fowler, J S AU - Leonido-Yee, M AU - Franceschi, D AU - Sedler, M J AU - Gatley, S J AU - Hitzemann, R AU - Ding, Y S AU - Logan, J AU - Wong, C AU - Miller, E N AD - Department of Psychiatry, State University of New York at Stony Brook, USA. volkow@bnl.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 377 EP - 382 VL - 158 IS - 3 SN - 0002-953X, 0002-953X KW - Carbon Radioisotopes KW - 0 KW - Carrier Proteins KW - Dopamine Plasma Membrane Transport Proteins KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Methylphenidate KW - 207ZZ9QZ49 KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Neuropsychological Tests -- statistics & numerical data KW - Cerebellum -- diagnostic imaging KW - Caudate Nucleus -- diagnostic imaging KW - Caudate Nucleus -- metabolism KW - Brain Chemistry -- drug effects KW - Humans KW - Verbal Learning -- drug effects KW - Caudate Nucleus -- drug effects KW - Putamen -- diagnostic imaging KW - Cerebellum -- metabolism KW - Cerebellum -- drug effects KW - Adult KW - Putamen -- metabolism KW - Male KW - Female KW - Putamen -- drug effects KW - Methylphenidate -- metabolism KW - Carrier Proteins -- metabolism KW - Brain -- drug effects KW - Methamphetamine -- adverse effects KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Psychomotor Disorders -- chemically induced KW - Brain -- diagnostic imaging KW - Psychomotor Disorders -- diagnosis KW - Carrier Proteins -- drug effects KW - Tomography, Emission-Computed -- statistics & numerical data KW - Methamphetamine -- metabolism KW - Methamphetamine -- pharmacology KW - Psychomotor Disorders -- metabolism KW - Dopamine -- analysis KW - Carrier Proteins -- analysis KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76979341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Association+of+dopamine+transporter+reduction+with+psychomotor+impairment+in+methamphetamine+abusers.&rft.au=Volkow%2C+N+D%3BChang%2C+L%3BWang%2C+G+J%3BFowler%2C+J+S%3BLeonido-Yee%2C+M%3BFranceschi%2C+D%3BSedler%2C+M+J%3BGatley%2C+S+J%3BHitzemann%2C+R%3BDing%2C+Y+S%3BLogan%2C+J%3BWong%2C+C%3BMiller%2C+E+N&rft.aulast=Volkow&rft.aufirst=N&rft.date=2001-03-01&rft.volume=158&rft.issue=3&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-03-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi AN - 17826037; 4855162 AB - Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been determined for strains HB19 and B31 to 1.8 and 2.5 Aa resolution, respectively. The three-dimensional structure is predominantly helical. This is in contrast to the structure of OspA, a major surface protein mainly present when spirochetes are residing in the midgut of unfed ticks, which is mostly s-sheet. The surface of OspC that would project away from the spirochetes membrane has a region of strong negative electrostatic potential which may be involved in binding to positively charged host ligands. This feature is present only on OspCs from strains known to cause invasive human disease. JF - EMBO Journal AU - Kumaran, D AU - Eswaramoorthy, S AU - Luft, B J AU - Koide, S AU - Dunn, J J AU - Lawson, CL AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA, swami@bnl.gov Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 971 EP - 978 VL - 20 IS - 5 SN - 0261-4189, 0261-4189 KW - OspC protein KW - Microbiology Abstracts B: Bacteriology KW - Cell surface KW - Antigens KW - Borrelia burgdorferi KW - Crystal structure KW - Proteins KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17826037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Crystal+structure+of+outer+surface+protein+C+%28OspC%29+from+the+Lyme+disease+spirochete%2C+Borrelia+burgdorferi&rft.au=Kumaran%2C+D%3BEswaramoorthy%2C+S%3BLuft%2C+B+J%3BKoide%2C+S%3BDunn%2C+J+J%3BLawson%2C+CL%3BSwaminathan%2C+S&rft.aulast=Kumaran&rft.aufirst=D&rft.date=2001-03-01&rft.volume=20&rft.issue=5&rft.spage=971&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Borrelia burgdorferi; Cell surface; Antigens; Crystal structure; Proteins ER - TY - JOUR T1 - In situ dehydration of yugawaralite AN - 52169272; 2001-073746 AB - The structural response of the natural zeolite yugawaralite (CaAl (sub 2) Si (sub 6) O (sub 16) .4H (sub 2) O) upon thermally induced dehydration has been studied by Rietveld analysis of temperature-resolved powder diffraction data collected in situ in the temperature range 315-791 K using synchrotron radiation. The room-temperature monoclinic structure [Pc, a = 6.73200(9), b = 14.0157(2), c = 10.0607(1) Aa, beta = 111.189(1) degrees , Z = 2, at 315 K] has the Ca cations in the channels coordinated to four framework O atoms and to four water molecules, with two of the water sites (OW1 and OW4) showing positional disorder progressively disappearing as the dehydration proceeds. The yugawaralite structure reacts to the release of water molecules with small changes in the Ca-O bond distances and minor distortions of the tetrahedral framework up to about 695 K. Above this temperature the Ca coordination falls below 7 (four framework O atoms and three water molecules) and a major rearrangement in the cation coordination takes place, causing a first order phase transition involving both a large decrease in the cell volume and the change in the space group symmetry. A satisfactory structure model for the high-temperature phase stable in the range 695-791 K could not be obtained because of the complexity of the structure. A model approximately describing the average structure [Pn, a = 12.703(1), b = 13.067(1), c = 9.839(1) Aa, beta = 110.894(9), Z = 4, at 749 K] has been used to follow the temperature evolution of the cell parameters in the measured temperature range. This model involves a sixfold coordination of the Ca cations (five framework O atoms and one water molecule). There is no indication of significant structure changes before collapse, likely occurring when the last water molecule is expelled from the structure and the cation coordination drops below 6, as observed in other Ca-rich zeolites (i.e., laumontite, scolecite, mesolite). JF - American Mineralogist AU - Artioli, Gilberto AU - Stahl, Kenny AU - Cruciani, Giuseppe AU - Gualtieri, Alessandro AU - Hanson, Jonathan Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 185 EP - 192 PB - Mineralogical Society of America, Washington, DC VL - 86 IS - 1-2 SN - 0003-004X, 0003-004X KW - silicates KW - yugawaralite KW - zeolite group KW - framework silicates KW - dehydration KW - Rietveld refinement KW - P-T conditions KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52169272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=In+situ+dehydration+of+yugawaralite&rft.au=Artioli%2C+Gilberto%3BStahl%2C+Kenny%3BCruciani%2C+Giuseppe%3BGualtieri%2C+Alessandro%3BHanson%2C+Jonathan&rft.aulast=Artioli&rft.aufirst=Gilberto&rft.date=2001-02-01&rft.volume=86&rft.issue=1-2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 16 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - dehydration; framework silicates; P-T conditions; Rietveld refinement; silicates; yugawaralite; zeolite group ER - TY - JOUR T1 - Synchrotron X-ray study of hydration dynamics in the synthetic swelling clay Na-fluorohectorite AN - 742923603; 2010-064623 JF - Proceedings of the International Clay Conference AU - Di Masi, E AU - Fossum, J O AU - da Silva, G J A2 - Dominguez, Eduardo A. A2 - Mas, Graciela R. A2 - Cravero, Fernanda Y1 - 2001 PY - 2001 DA - 2001 SP - 427 EP - 434 PB - Elsevier VL - 12 KW - silicates KW - experimental studies KW - X-ray diffraction data KW - halogens KW - alkali metals KW - hectorite KW - sodium KW - temperature KW - fluorohectorite KW - clay minerals KW - synchrotron radiation KW - hydration KW - fluorine KW - rheology KW - metals KW - expansive materials KW - sheet silicates KW - vermiculite KW - dehydration KW - chemical composition KW - synthetic materials KW - 06A:Sedimentary petrology KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742923603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+International+Clay+Conference&rft.atitle=Synchrotron+X-ray+study+of+hydration+dynamics+in+the+synthetic+swelling+clay+Na-fluorohectorite&rft.au=Di+Masi%2C+E%3BFossum%2C+J+O%3Bda+Silva%2C+G+J&rft.aulast=Di+Masi&rft.aufirst=E&rft.date=2001-01-01&rft.volume=12&rft.issue=&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+International+Clay+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 12th international clay conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 15 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #06482 N1 - SubjectsTermNotLitGenreText - alkali metals; chemical composition; clay minerals; dehydration; expansive materials; experimental studies; fluorine; fluorohectorite; halogens; hectorite; hydration; metals; rheology; sheet silicates; silicates; sodium; synchrotron radiation; synthetic materials; temperature; vermiculite; X-ray diffraction data ER - TY - JOUR T1 - Clustered DNA damages induced by high and low LET radiation, including heavy ions. AN - 72379829; 11776262 AB - Clustered DNA damages--here defined as two or more lesions (strand breaks, oxidized purines, oxidized pyrimidines or abasic sites) within a few helical turns--have been postulated as difficult to repair accurately, and thus highly significant biological lesions. Further, attempted repair of clusters may produce double strand breaks (DSBs). However, until recently, there was no way to measure ionizing radiation-induced clustered damages, except DSB. We recently described an approach for measuring classes of clustered damages (oxidized purine clusters, oxidized pyrimidine clusters, abasic clusters, along with DSB). We showed that ionizing radiation (gamma rays and Fe ions, 1 GeV/amu) does induce such clusters in genomic DNA in solution and in human cells. These studies also showed that each damage cluster results from one radiation hit (and its track), thus indicating that they can be induced by very low doses of radiation, i.e. two independent hits are not required for cluster induction. Further, among all complex damages, double strand breaks comprise--at most-- ~20%, with the other clustered damages being at least 80%. JF - Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) AU - Sutherland, B M AU - Bennett, P V AU - Schenk, H AU - Sidorkina, O AU - Laval, J AU - Trunk, J AU - Monteleone, D AU - Sutherland, J AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 202 EP - 204 VL - 17 Suppl 1 SN - 1120-1797, 1120-1797 KW - Cesium Radioisotopes KW - 0 KW - DNA KW - 9007-49-2 KW - Iron KW - E1UOL152H7 KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Oxidation-Reduction KW - Cells, Cultured KW - Humans KW - Dose-Response Relationship, Radiation KW - Heavy Ions KW - Gamma Rays KW - DNA Damage KW - DNA -- radiation effects KW - Linear Energy Transfer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72379829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physica+medica+%3A+PM+%3A+an+international+journal+devoted+to+the+applications+of+physics+to+medicine+and+biology+%3A+official+journal+of+the+Italian+Association+of+Biomedical+Physics+%28AIFB%29&rft.atitle=Clustered+DNA+damages+induced+by+high+and+low+LET+radiation%2C+including+heavy+ions.&rft.au=Sutherland%2C+B+M%3BBennett%2C+P+V%3BSchenk%2C+H%3BSidorkina%2C+O%3BLaval%2C+J%3BTrunk%2C+J%3BMonteleone%2C+D%3BSutherland%2C+J&rft.aulast=Sutherland&rft.aufirst=B&rft.date=2001-01-01&rft.volume=17+Suppl+1&rft.issue=&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Physica+medica+%3A+PM+%3A+an+international+journal+devoted+to+the+applications+of+physics+to+medicine+and+biology+%3A+official+journal+of+the+Italian+Association+of+Biomedical+Physics+%28AIFB%29&rft.issn=11201797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-12 N1 - Date created - 2002-01-02 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The integrating ion imager: a device for determining heavy ion doses during irradiations. AN - 72377270; 11771538 AB - We have designed and built an integrating ion imaging system (I3) that records the spatial distribution of the dose of heavy ions incident on samples irradiated at the radiobiology beamline of the Alternating Gradient Synchrotron at Brookhaven National Laboratory. The images of dose are integrated over the duration of the exposure. Unlike the images formed on X-ray film, these images are linear with the incident dose. Heavy ions are incident on a phosphor that is located just behind the sample position. Visible light emitted from the phosphor is collected by a lens and focused onto a scientific grade charge coupled device (CCD) cooled to about -45 degrees C. The phosphor and CCD camera are integral parts of a modular sample holder designed for irradiating molecular samples, which is easily mounted on the sample platform of the beamline. The imager can be adapted to other types of samples. The present CCD image is digitized to 14 bits (16,384 intensity levels), but the dynamic range is extended by adjusting the aperture of the CCD camera lens. Digital images from the CCD are routinely transferred over the BNL local area network for archival storage on a UNIX server, from which they can be opened from any authorized computer with access to the Internet. Images obtained with no sample in place record the dose at all points on the target field. When a sample is in place, an image of the sample appears providing its exact location with respect to fiducial marks recorded for all images. Areas surrounding the image of the sample are used in comparison with companion no-sample images to get exact doses over the sample. The contrast mechanism responsible for image formation is the shift along the Bragg curve resulting from loss of energy of the ions as they pass through the sample--not from a change in ion flux reaching the phosphor. The sharpness of the images formed with the DNA samples we have recorded indicates that neither scattering of the incident heavy ions or the generation of secondary ions contribute significantly. JF - Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) AU - Sutherland, J C AU - Monteleone, D C AU - Trunk, J G AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 137 EP - 140 VL - 17 Suppl 1 SN - 1120-1797, 1120-1797 KW - Iron KW - E1UOL152H7 KW - Space life sciences KW - Radiation Dosage KW - Equipment Design KW - Scattering, Radiation KW - Radiometry KW - Light KW - Elementary Particles KW - Internet KW - Heavy Ions KW - Synchrotrons KW - Photography -- instrumentation KW - Image Processing, Computer-Assisted UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72377270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physica+medica+%3A+PM+%3A+an+international+journal+devoted+to+the+applications+of+physics+to+medicine+and+biology+%3A+official+journal+of+the+Italian+Association+of+Biomedical+Physics+%28AIFB%29&rft.atitle=The+integrating+ion+imager%3A+a+device+for+determining+heavy+ion+doses+during+irradiations.&rft.au=Sutherland%2C+J+C%3BMonteleone%2C+D+C%3BTrunk%2C+J+G&rft.aulast=Sutherland&rft.aufirst=J&rft.date=2001-01-01&rft.volume=17+Suppl+1&rft.issue=&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Physica+medica+%3A+PM+%3A+an+international+journal+devoted+to+the+applications+of+physics+to+medicine+and+biology+%3A+official+journal+of+the+Italian+Association+of+Biomedical+Physics+%28AIFB%29&rft.issn=11201797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-12 N1 - Date created - 2001-12-27 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Frequencies and relative levels of clustered damages in DNA exposed to gamma rays in radioquenching vs. nonradioquenching conditions. AN - 72356360; 11746750 AB - Clustered damage induced by ionizing radiation--two or more oxidized bases, abasic sites, or strand breaks within a few DNA helical turns--have been postulated to be major lethal and/or mutagenic sites. Although they have recently been shown to be induced in genomic DNAs by ionizing photons and particles, little is known of the factors that affect their yields or the relative levels of the classes of clusters. Toward this aim we have investigated the effect of DNA milieu, specifically, a nonradioquenching (phosphate) or radioquenching (Tris) solution, upon the generation of clustered lesions in a well-defined molecule, T7 bacteriophage DNA. Irradiation of DNA in Tris reduces the yields of all clustered damages to 1-3% of the levels formed in phosphate. Further, although the percentage of the total clusters in oxidized purine clusters is largely unchanged, and the level of abasic clusters decreases, the frequencies of double-strand breaks and oxidized pyrimidine clusters increase in the radioquenching solution. The ratio of the level of oxidized pyrimidine clusters to double-strand breaks in a DNA in radioquenching solution is similar to that obtained in DNA in human cells, also a radioquenching environment. JF - Environmental and molecular mutagenesis AU - Sutherland, B M AU - Bennett, P V AU - Weinert, E AU - Sidorkina, O AU - Laval, J AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. BMS@BNL.GOV Y1 - 2001 PY - 2001 DA - 2001 SP - 159 EP - 165 VL - 38 IS - 2-3 SN - 0893-6692, 0893-6692 KW - DNA, Viral KW - 0 KW - Phosphates KW - Tromethamine KW - 023C2WHX2V KW - Index Medicus KW - Bacteriophage T7 -- radiation effects KW - Humans KW - Bacteriophage T7 -- genetics KW - Gamma Rays KW - DNA Damage -- radiation effects KW - DNA, Viral -- genetics KW - DNA, Viral -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72356360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Frequencies+and+relative+levels+of+clustered+damages+in+DNA+exposed+to+gamma+rays+in+radioquenching+vs.+nonradioquenching+conditions.&rft.au=Sutherland%2C+B+M%3BBennett%2C+P+V%3BWeinert%2C+E%3BSidorkina%2C+O%3BLaval%2C+J&rft.aulast=Sutherland&rft.aufirst=B&rft.date=2001-01-01&rft.volume=38&rft.issue=2-3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-09 N1 - Date created - 2001-12-17 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Clustered DNA damages as dosemeters for ionising radiation exposure and biological responses. AN - 72336942; 11763355 AB - Clustered DNA damages--two or more lesions (oxidised bases. abasic sites, or strand breaks) within a few DNA helical turns on opposing strands--are induced in DNA in solution and in vivo in human cells by ionising radiation. They have been postulated to be difficult to repair, and thus of potentially high biological significance. Since the total of clustered damages produced by ionising radiation is at about 3 to 4 times higher levels than double-strand breaks and are apparently absent in unirradiated cells, levels of clustered damages present immediately alter radiation exposure could serve as sensitive dosemeters of radiation exposure. Since some clusters may not be repairable and may accumulate in cells, they might also be useful as integrating dosemeters of biological effects of radiation damage. JF - Radiation protection dosimetry AU - Sutherland, B M AU - Bennett, P V AU - Saparbaev, M AU - Sutherland, J C AU - Laval, J AD - Biology Department, Brookhaven National Laboratory Upton, NY 11973-5000, USA. BMS@BNL.GOV Y1 - 2001 PY - 2001 DA - 2001 SP - 33 EP - 38 VL - 97 IS - 1 SN - 0144-8420, 0144-8420 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - Non-programmatic KW - Oxidation-Reduction KW - Radiation Dosage KW - DNA Repair KW - Humans KW - Dose-Response Relationship, Radiation KW - Radiation, Ionizing KW - DNA Damage -- radiation effects KW - DNA -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72336942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=Clustered+DNA+damages+as+dosemeters+for+ionising+radiation+exposure+and+biological+responses.&rft.au=Sutherland%2C+B+M%3BBennett%2C+P+V%3BSaparbaev%2C+M%3BSutherland%2C+J+C%3BLaval%2C+J&rft.aulast=Sutherland&rft.aufirst=B&rft.date=2001-01-01&rft.volume=97&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-23 N1 - Date created - 2001-12-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Sorption of radioactive contaminants by sediment from the Kara Sea. AN - 72199671; 11601528 AB - The purpose of this study is to quantify some of the parameters needed to perform near-field modelling of sites in the Kara Sea that were impacted by the disposal of radioactive waste. The parameters of interest are: the distribution coefficients (Kd) for several important radionuclides, the mineralogy of the sediment, and the relationship of Kd to liquid-to-solid ratio. Sediment from the Kara Sea (location: 73 degrees 00'N, 58 degrees 00'E) was sampled from a depth of 287 m on August 23/24, 1992. Analysis of the material included mineralogy, grain size and total organic carbon (TOC). Uptake kinetics were determined for 85Sr, 137Cs, 241Am, 99Tc, 1251, 232U and 210Pb and distribution coefficients (Kd) were determined for these radionuclides using batch type experiments. Sorption isotherms, developed for 137Cs, 85Sr and 99Tc, were linear in each case. Increasing the liquid-to-solid ratio strongly increased uptake of 137Cs and moderately increased uptake of 99Tc. Analysis for anthropogenic radionuclides indicated the presence only of 239/240Pu in the sediment with the highest activity (at the top section of the core) being 0.420 Bq kg(-1). Other anthropogenic radionuclides were below detection limits. JF - Marine pollution bulletin AU - Fuhrmann, M AU - Zhou, H AU - Neiheisel, J AU - Dyer, R AD - Brookhaven National Laboratory, Environmental and Waste Technology Center, Upton, NY 11973-5000, USA. fuhrmann@bnl.gov PY - 2001 SP - 102 EP - 110 VL - 43 IS - 1-6 SN - 0025-326X, 0025-326X KW - Radioactive Waste KW - 0 KW - Radioisotopes KW - Soil Pollutants, Radioactive KW - Water Pollutants, Radioactive KW - Index Medicus KW - Oceans and Seas KW - Seawater KW - Absorption KW - Arctic Regions KW - Radioisotopes -- metabolism KW - Geologic Sediments -- analysis KW - Water Pollution, Radioactive -- analysis KW - Water Pollutants, Radioactive -- pharmacokinetics KW - Water Pollutants, Radioactive -- analysis KW - Soil Pollutants, Radioactive -- pharmacokinetics KW - Soil Pollutants, Radioactive -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72199671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+pollution+bulletin&rft.atitle=Sorption+of+radioactive+contaminants+by+sediment+from+the+Kara+Sea.&rft.au=Fuhrmann%2C+M%3BZhou%2C+H%3BNeiheisel%2C+J%3BDyer%2C+R&rft.aulast=Fuhrmann&rft.aufirst=M&rft.date=2001-01-01&rft.volume=43&rft.issue=1-6&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Marine+pollution+bulletin&rft.issn=0025326X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-14 N1 - Date created - 2001-10-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Radiation protection and environmental management at the relativistic heavy ion collider. AN - 71283721; 11843082 AB - The Relativistic Heavy Ion Collider (RHIC) is a high energy hadron accelerator built to study basic nuclear physics. It consists of two counter-rotating beams of fully stripped gold ions that are accelerated in two rings to an energy of 100 GeV/nucleon or protons at 250 GeV/c. The beams can be stored for a period of five to ten hours and brought into collision for experiments during that time. The first major physics objective is to recreate a state of matter, the quark-gluon plasma, that has been predicted to have existed at a short time after the creation of the universe. Because there are only a few other high energy particle accelerators like RHIC in the world, the rules promulgated in the US Code of Federal Regulations under the Atomic Energy Act, State regulations, or international guidance documents do not cover prompt radiation from accelerators to govern directly the design and operation of a superconducting collider. Special design criteria for prompt radiation were developed to provide guidance tor the design of radiation shielding. Environmental Management at RHIC is accomplished through the ISO 14001 Environmental Management System. The applicability, benefits, and implementation of ISO 14001 within the framework of a large research accelerator complex are discussed in the paper. JF - Radiation protection dosimetry AU - Musolino, S V AU - Briggs, S L AU - Stevens, A J AD - Brookhaven National Laboratory Upton, New York 11973-5000, USA. musolino@bnl.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 323 EP - 332 VL - 96 IS - 4 SN - 0144-8420, 0144-8420 KW - Ions KW - 0 KW - Index Medicus KW - Environment KW - Radiation Injuries -- prevention & control KW - Humans KW - Research -- standards KW - Nuclear Physics -- standards KW - Radiation Protection KW - Particle Accelerators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71283721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=Radiation+protection+and+environmental+management+at+the+relativistic+heavy+ion+collider.&rft.au=Musolino%2C+S+V%3BBriggs%2C+S+L%3BStevens%2C+A+J&rft.aulast=Musolino&rft.aufirst=S&rft.date=2001-01-01&rft.volume=96&rft.issue=4&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-16 N1 - Date created - 2002-02-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - BOOK T1 - Acid rain and deposition AN - 52036116; 2003-005892 JF - Encyclopedia of biodiversity; Volume 1, A-C AU - Hendrey, George R A2 - Levin, Simon Asher Y1 - 2001 PY - 2001 DA - 2001 PB - Academic Press, San Diego, CA SN - 0122268660 KW - soils KW - forests KW - sulfur dioxide KW - cation exchange capacity KW - surface water KW - pollution KW - ecosystems KW - atmospheric precipitation KW - vegetation KW - environmental effects KW - biota KW - ground water KW - acid rain KW - dry deposition KW - aerosols KW - acidification KW - ecology KW - rain KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52036116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hendrey%2C+George+R&rft.aulast=Hendrey&rft.aufirst=George&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0122268660&rft.btitle=Acid+rain+and+deposition&rft.title=Acid+rain+and+deposition&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 12 N1 - PubXState - CA N1 - Document feature - 3 tables, sketch maps N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Mechanical property issues for geothermal well cements AN - 51160781; 2003-081375 AB - This paper addresses material requirements for cements used in geothermal wells. The approach taken combines laboratory tests with engineering finite element analysis of typical cased and cemented geothermal wellbore. It is shown that the usual design approach, which is based on compressive strength requirements, is inadequate. Development of cements with enhanced tensile strength as well as appropriate testing for defining respective failure loads is needed in future studies. JF - Transactions - Geothermal Resources Council AU - Philippacopoulos, A J AU - Berndt, M L AU - Garg, Sabodh K AU - Hiriart, Gerardo Y1 - 2001 PY - 2001 DA - 2001 SP - 119 EP - 124 PB - GRC - Geothermal Resources Council, Davis, CA VL - 25 SN - 0193-5933, 0193-5933 KW - failures KW - technology KW - strength KW - geothermal wells KW - statistical analysis KW - rock mechanics KW - exploration KW - geothermal energy KW - finite element analysis KW - drilling KW - cement KW - design KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51160781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+-+Geothermal+Resources+Council&rft.atitle=Mechanical+property+issues+for+geothermal+well+cements&rft.au=Philippacopoulos%2C+A+J%3BBerndt%2C+M+L%3BGarg%2C+Sabodh+K%3BHiriart%2C+Gerardo&rft.aulast=Philippacopoulos&rft.aufirst=A&rft.date=2001-01-01&rft.volume=25&rft.issue=&rft.spage=119&rft.isbn=0934412855&rft.btitle=&rft.title=Transactions+-+Geothermal+Resources+Council&rft.issn=01935933&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geothermal Resources Council 2001 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 6 N1 - PubXState - CA N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - cement; design; drilling; exploration; failures; finite element analysis; geothermal energy; geothermal wells; rock mechanics; statistical analysis; strength; technology ER - TY - JOUR T1 - Sorption of cadmium on humic acid; mechanistic and kinetic studies with atomic force microscopy and X-ray absorption fine structure spectroscopy AN - 50274580; 2005-067922 AB - Humic acids (HA) constitute a major fraction of the organic matter in soils and sediments. Little is known about the kinetics and mechanisms of Cd sorption by HAs, especially those pertaining to the surface features and structure of the Cd-humate complexes. We investigated Cd sorption by HA using the conventional batch method, N (sub 2) -BET method, atomic force microscopy (AFM), and extended X-ray absorption fine structure (EXAFS) spectroscopy to gain a better understanding of the kinetics and mechanisms. Cadmium sorption by HA can be described by the parabolic diffusion equation. The increase in the apparent diffusion coefficient with an increase in the initial Cd concentration was less pronounced at higher initial Cd concentrations, apparently due to an enhancement in aggregation of the Cd-humate complexes. The HA before and after Cd sorption at Cd concentrations < or =10 (super -6) M in different reaction times was spheroidal in shape. The Cd-humate complexes formed at 10 (super -4) and 10 (super -3) M Cd gradually changed to resemble the shape of a bean with increasing reaction time, thereby substantially decreasing their specific surface. Cadmium ions raveled the spheroidal HA particles into a bean-like structure by coordinating to six O atoms from the functional groups of HA, with a Cd-O distance of 2.297(2) Aa. The Cd-O bond strength decreased with increasing initial Cd concentration. JF - Canadian Journal of Soil Science AU - Liu, C AU - Frenkel, A I AU - Vairavamurthy, A AU - Huang, P M A2 - Huang, P. M. A2 - Arshad, M. A. A2 - Dinel, H. A2 - Goh, T. B. Y1 - 2001 PY - 2001 DA - 2001 SP - 337 EP - 348 PB - Agricultural Institute of Canada, Ottawa, ON VL - 81 IS - 3 SN - 0008-4271, 0008-4271 KW - soils KW - sorption KW - XAFS spectra KW - humic acids KW - X-ray spectra KW - organic compounds KW - organic acids KW - humic substances KW - metals KW - cadmium KW - spectra KW - kinetics KW - 02C:Geochemistry of rocks, soils, and sediments KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50274580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+Journal+of+Soil+Science&rft.atitle=Sorption+of+cadmium+on+humic+acid%3B+mechanistic+and+kinetic+studies+with+atomic+force+microscopy+and+X-ray+absorption+fine+structure+spectroscopy&rft.au=Liu%2C+C%3BFrenkel%2C+A+I%3BVairavamurthy%2C+A%3BHuang%2C+P+M&rft.aulast=Liu&rft.aufirst=C&rft.date=2001-01-01&rft.volume=81&rft.issue=3&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Canadian+Journal+of+Soil+Science&rft.issn=00084271&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - First symposium of the Canadian National Chapter of the International Humic Substances Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 38 N1 - PubXState - ON N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - CODEN - CJSSAR N1 - SubjectsTermNotLitGenreText - cadmium; humic acids; humic substances; kinetics; metals; organic acids; organic compounds; soils; sorption; spectra; X-ray spectra; XAFS spectra ER - TY - JOUR T1 - Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor. AN - 72356005; 11044890 AB - There is a greater prevalence of cigarette smoking among cocaine-dependent individuals and hyperactive children treated with stimulants (e.g., methylphenidate, MP). However, little is known about the neurochemical basis of the interaction between nicotine and cocaine or MP. It is thought that the reinforcing effects of cocaine and MP are due partly to increases in synaptic DA in the nucleus accumbens (NAc). These measurable increases are secondary to the blockade of the DA transporter. In contrast, nicotine stimulates acetylcholine receptors located presynaptically on dopaminergic projections from the ventral tegmental area (VTA) to the NAc and increases DA transmission. Here we investigate the effects of nicotine on NAc DA in animals simultaneously injected with cocaine or MP. Coadministration of nicotine (0.4 mg/kg s.c.) and cocaine (10 mg/kg i.p.) or MP (5 mg/kg i.p.) increased the extracellular NAc DA levels in an additive manner, while coadministration of nicotine (0. 4 mg/kg s.c.) and a higher dose of cocaine (20 mg/kg) or MP (10 mg/kg) clearly produced a synergistic elevation in NAc DA. These findings suggest that the degree of DA transporter (DAT) occupancy contributes to the synergistic interaction between nicotine and cocaine or MP. JF - Synapse (New York, N.Y.) AU - Gerasimov, M R AU - Franceschi, M AU - Volkow, N D AU - Rice, O AU - Schiffer, W K AU - Dewey, S L AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA. madina@bnl.gov Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 432 EP - 437 VL - 38 IS - 4 SN - 0887-4476, 0887-4476 KW - Carrier Proteins KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Dopamine Uptake Inhibitors KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Nicotinic Agonists KW - Slc6a3 protein, rat KW - Methylphenidate KW - 207ZZ9QZ49 KW - Nicotine KW - 6M3C89ZY6R KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Injections, Intraperitoneal KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Injections, Subcutaneous KW - Nucleus Accumbens -- metabolism KW - Dopamine -- metabolism KW - Drug Synergism KW - Male KW - Carrier Proteins -- antagonists & inhibitors KW - Methylphenidate -- pharmacology KW - Nicotine -- pharmacology KW - Nicotinic Agonists -- pharmacology KW - Cocaine -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72356005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Synergistic+interactions+between+nicotine+and+cocaine+or+methylphenidate+depend+on+the+dose+of+dopamine+transporter+inhibitor.&rft.au=Gerasimov%2C+M+R%3BFranceschi%2C+M%3BVolkow%2C+N+D%3BRice%2C+O%3BSchiffer%2C+W+K%3BDewey%2C+S+L&rft.aulast=Gerasimov&rft.aufirst=M&rft.date=2000-12-15&rft.volume=38&rft.issue=4&rft.spage=432&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-14 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The international at-sea intercomparison of fCO (sub 2) systems during the R/V Meteor Cruise 36/1 in the North Atlantic Ocean AN - 52141670; 2002-017591 AB - The "International Intercomparison Exercise of fCO (sub 2) Systems" was carried out in 1996 during the R/V Meteor Cruise 36/1 from Bermuda/UK to Gran Canaria/Spain. Nine groups from six countries (Australia, Denmark, France, Germany, Japan, USA) participated in this exercise, bringing together 15 participants with seven underway fugacity of carbon dioxide (fCO (sub 2) ) systems, one discrete fCO (sub 2) system, and two underway pH systems, as well as systems for discrete measurement of total alkalinity and total dissolved inorganic carbon. Here, we compare surface seawater fCO (sub 2) measured synchronously by all participating instruments. A common infrastructure (seawater and calibration gas supply), different quality checks (performance of calibration procedures for CO (sub 2) , temperature measurements) and a common procedure for calculation of final fCO (sub 2) were provided to reduce the largest possible amount of controllable sources of error. The results show that under such conditions underway measurements of the fCO (sub 2) in surface seawater and overlying air can be made to a high degree of agreement (+ or -1 mu atm) with a variety of possible equilibrator and system designs. Also, discrete fCO (sub 2) measurements can be made in good agreement (+ or -3 mu atm) with underway fCO (sub 2) data sets. However, even well-designed systems, which are operated without any obvious sign of malfunction, can show significant differences of the order of 10 mu atm. Based on our results, no "best choice" for the type of the equilibrator nor specifics on its dimensions and flow rates of seawater and air can be made in regard to the achievable accuracy of the fCO (sub 2) system. Measurements of equilibrator temperature do not seem to be made with the required accuracy resulting in significant errors in fCO (sub 2) results. Calculation of fCO (sub 2) from high-quality total dissolved inorganic carbon (C (sub T) ) and total alkalinity (A (sub T) ) measurements does not yield results comparable in accuracy and precision to fCO (sub 2) measurements. JF - Marine Chemistry AU - Koertzinger, Arne AU - Mintrop, Ludger AU - Wallace, Douglas W R AU - Johnson, Kenneth M AU - Neill, Craig AU - Tilbrook, Bronte AU - Towler, Philip AU - Inoue, Hisayuki Y AU - Ishii, Masao AU - Shaffer, Gary AU - Torres Saavedra, Rodrigo F AU - Ohtaki, Eiji AU - Yamashita, Eiji AU - Poisson, Alain AU - Brunet, Christian AU - Schauer, Bernard AU - Goyet, Catherine AU - Eischeid, Greg A2 - Tsunogai, Shizuo A2 - Wong, Chi Shing Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 171 EP - 192 PB - Elsevier, Amsterdam VL - 72 IS - 2-4 SN - 0304-4203, 0304-4203 KW - sea water KW - calibration KW - fugacity KW - measurement KW - geochemical cycle KW - carbon dioxide KW - dissolved materials KW - carbon KW - alkalinity KW - carbon cycle KW - sea-surface temperature KW - North Atlantic KW - accuracy KW - pH KW - instruments KW - Atlantic Ocean KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52141670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Chemistry&rft.atitle=The+international+at-sea+intercomparison+of+fCO+%28sub+2%29+systems+during+the+R%2FV+Meteor+Cruise+36%2F1+in+the+North+Atlantic+Ocean&rft.au=Koertzinger%2C+Arne%3BMintrop%2C+Ludger%3BWallace%2C+Douglas+W+R%3BJohnson%2C+Kenneth+M%3BNeill%2C+Craig%3BTilbrook%2C+Bronte%3BTowler%2C+Philip%3BInoue%2C+Hisayuki+Y%3BIshii%2C+Masao%3BShaffer%2C+Gary%3BTorres+Saavedra%2C+Rodrigo+F%3BOhtaki%2C+Eiji%3BYamashita%2C+Eiji%3BPoisson%2C+Alain%3BBrunet%2C+Christian%3BSchauer%2C+Bernard%3BGoyet%2C+Catherine%3BEischeid%2C+Greg&rft.aulast=Koertzinger&rft.aufirst=Arne&rft.date=2000-12-01&rft.volume=72&rft.issue=2-4&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Marine+Chemistry&rft.issn=03044203&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/03044203 LA - English DB - GeoRef N1 - Conference title - Second international symposium on Carbon dioxide in the oceans N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2002-01-01 N1 - Number of references - 32 N1 - Document feature - illus. incl. 3 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - MRCHBD N1 - SubjectsTermNotLitGenreText - accuracy; alkalinity; Atlantic Ocean; calibration; carbon; carbon cycle; carbon dioxide; dissolved materials; fugacity; geochemical cycle; instruments; measurement; North Atlantic; pH; sea water; sea-surface temperature ER - TY - JOUR T1 - A mechanistic evaluation of photosynthetic acclimation at elevated CO sub(2) AN - 17652420; 5308991 AB - Plants grown at elevated pCO sub(2) often fail to sustain the initial stimulation of net CO sub(2) uptake rate (A). This reduced, acclimated, stimulation of A often occurs concomitantly with a reduction in the maximum carboxylation velocity (V sub(c,max)) of Rubisco. To investigate this relationship we used the Farquhar model of C sub(3) photosynthesis to predict the minimum V sub(c,max) capable of supporting the acclimated stimulation in A observed at elevated pCO sub(2). For a wide range of species grown at elevated pCO sub(2) under contrasting conditions we found a strong correlation between observed and predicted values of V sub(c,max). This exercise mechanistically and quantitatively demonstrated that the observed acclimated stimulation of A and the simultaneous decrease in V sub(c,max) observed at elevated pCO sub(2) is mechanistically consistent. With the exception of plants grown at a high elevated pCO sub(2) (> 90 Pa), which show evidence of an excess investment in Rubisco, the failure to maintain the initial stimulation of A is almost entirely attributable to the decrease in V sub(c,max) and investment in Rubisco is coupled to requirements. JF - Global Change Biology AU - Rogers, A AU - Humphries, S W AD - Department of Environmental Sciences, Brookhaven National Laboratory, Upton, NY 11973-5000, USA, arogers@bnl.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 1005 EP - 1011 PB - Blackwell Science Ltd VL - 6 IS - 8 SN - 1354-1013, 1354-1013 KW - Ecology Abstracts KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17652420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Global+Change+Biology&rft.atitle=A+mechanistic+evaluation+of+photosynthetic+acclimation+at+elevated+CO+sub%282%29&rft.au=Rogers%2C+A%3BHumphries%2C+S+W&rft.aulast=Rogers&rft.aufirst=A&rft.date=2000-12-01&rft.volume=6&rft.issue=8&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Global+Change+Biology&rft.issn=13541013&rft_id=info:doi/10.1046%2Fj.1365-2486.2000.00375.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1046/j.1365-2486.2000.00375.x ER - TY - JOUR T1 - Polarized single-crystal and high-pressure FTIR spectra in the OH stretching region of coesite AN - 51934051; 2003-073798 JF - Eos, Transactions, American Geophysical Union AU - Koch-Mueller, Monika AU - Fei, Yingwei AU - Liu, Zhenxian AU - Anonymous Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1301 PB - American Geophysical Union, Washington, DC VL - 81 IS - 48, Suppl. SN - 0096-3941, 0096-3941 KW - silicates KW - polarization KW - experimental studies KW - pressure KW - silica minerals KW - high pressure KW - coesite KW - temperature KW - infrared spectra KW - molecular structure KW - hydroxyl ion KW - FTIR spectra KW - pleochroism KW - single-crystal method KW - hydrogen KW - framework silicates KW - spectra KW - anvil cells KW - chemical composition KW - high temperature KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51934051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Polarized+single-crystal+and+high-pressure+FTIR+spectra+in+the+OH+stretching+region+of+coesite&rft.au=Koch-Mueller%2C+Monika%3BFei%2C+Yingwei%3BLiu%2C+Zhenxian%3BAnonymous&rft.aulast=Koch-Mueller&rft.aufirst=Monika&rft.date=2000-11-01&rft.volume=81&rft.issue=48%2C+Suppl.&rft.spage=1301&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2000 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 3 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - anvil cells; chemical composition; coesite; experimental studies; framework silicates; FTIR spectra; high pressure; high temperature; hydrogen; hydroxyl ion; infrared spectra; molecular structure; pleochroism; polarization; pressure; silica minerals; silicates; single-crystal method; spectra; temperature ER - TY - JOUR T1 - Effects of sulfur emissions from Popocatepetl Volcano on the Central U.S. in June 1997 AN - 51904380; 2004-002058 JF - Eos, Transactions, American Geophysical Union AU - Benkovitz, Carmen M AU - Miller, Mark A AU - Schwartz, Stephen E AU - Easter, Richard C AU - Anonymous Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 37 EP - 38 PB - American Geophysical Union, Washington, DC VL - 81 IS - 48, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - sulfur dioxide KW - Denver County Colorado KW - plumes KW - sulfates KW - atmosphere KW - troposphere KW - Sevilleta New Mexico KW - Popocatepetl KW - Mexico KW - Denver Colorado KW - transport KW - volcanism KW - volcanoes KW - sulfur KW - aerosols KW - Colorado KW - AERONET KW - winds KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51904380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Effects+of+sulfur+emissions+from+Popocatepetl+Volcano+on+the+Central+U.S.+in+June+1997&rft.au=Benkovitz%2C+Carmen+M%3BMiller%2C+Mark+A%3BSchwartz%2C+Stephen+E%3BEaster%2C+Richard+C%3BAnonymous&rft.aulast=Benkovitz&rft.aufirst=Carmen&rft.date=2000-11-01&rft.volume=81&rft.issue=48%2C+Suppl.&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2000 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - AERONET; aerosols; atmosphere; Colorado; Denver Colorado; Denver County Colorado; Mexico; plumes; Popocatepetl; Sevilleta New Mexico; sulfates; sulfur; sulfur dioxide; transport; troposphere; United States; volcanism; volcanoes; winds ER - TY - JOUR T1 - Reaction of cesium and strontium in aqueous colloidal aluminosilicate systems at high pH AN - 51836507; 2004-046589 JF - Eos, Transactions, American Geophysical Union AU - Chorover, Jon AU - Karthikeyan, K G AU - Mueller, Karl T AU - Vairavamurthy, A Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1260 PB - American Geophysical Union, Washington, DC VL - 81 IS - 48, Suppl. SN - 0096-3941, 0096-3941 KW - silicates KW - sorption KW - X-ray diffraction data KW - isotopes KW - aqueous solutions KW - NMR spectra KW - infrared spectra KW - FTIR spectra KW - radioactive isotopes KW - chemical reactions KW - cesium KW - aluminosilicates KW - spectra KW - pH KW - migration KW - alkaline earth metals KW - experimental studies KW - colloidal materials KW - alkali metals KW - kaolinite KW - clay minerals KW - metals KW - sheet silicates KW - strontium KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51836507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Reaction+of+cesium+and+strontium+in+aqueous+colloidal+aluminosilicate+systems+at+high+pH&rft.au=Chorover%2C+Jon%3BKarthikeyan%2C+K+G%3BMueller%2C+Karl+T%3BVairavamurthy%2C+A&rft.aulast=Chorover&rft.aufirst=Jon&rft.date=2000-11-01&rft.volume=81&rft.issue=48%2C+Suppl.&rft.spage=1260&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2000 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - alkali metals; alkaline earth metals; aluminosilicates; aqueous solutions; cesium; chemical reactions; clay minerals; colloidal materials; experimental studies; FTIR spectra; infrared spectra; isotopes; kaolinite; metals; migration; NMR spectra; pH; radioactive isotopes; sheet silicates; silicates; sorption; spectra; strontium; X-ray diffraction data ER - TY - JOUR T1 - End-of-life management and recycling of PV modules AN - 17813427; 4847673 AB - Photovoltaics (PV) technology is undergoing a transition to a new generation of efficient, low-cost products based on thin films of photoactive materials. PV technology has definite environmental advantages over competing electricity generation technologies, and the PV industry follows a pro-active life-cycle approach to prevent future environmental damage and to sustain these advantages. An issue with potential environmental implications is the decommissioning of solar cells at the end of their useful life; a viable answer is recycling them when they are no longer useful. This paper presents a feasibility study for recycling thin-film solar cells and manufacturing waste, based on the current collection/recycling infrastructure and on current and emerging recycling technologies. Technology already exists for recycling PV modules and costs associated with recycling are not excessive. JF - Energy Policy AU - Fthenakis, V M AD - Environmental & Waste Technology Group, Department of Advanced Technology, Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973-5000, USA, vmf@bnl.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1051 EP - 1058 VL - 28 IS - 14 SN - 0301-4215, 0301-4215 KW - solar cells KW - Pollution Abstracts KW - Life cycle analysis KW - Environmental impact KW - Recycling KW - Waste management KW - Economics KW - Solar energy KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17813427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Energy+Policy&rft.atitle=End-of-life+management+and+recycling+of+PV+modules&rft.au=Fthenakis%2C+V+M&rft.aulast=Fthenakis&rft.aufirst=V&rft.date=2000-11-01&rft.volume=28&rft.issue=14&rft.spage=1051&rft.isbn=&rft.btitle=&rft.title=Energy+Policy&rft.issn=03014215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Waste management; Solar energy; Recycling; Life cycle analysis; Economics; Environmental impact ER - TY - JOUR T1 - Substrate-dependent mutant complementation to select fatty acid desaturase variants for metabolic engineering of plant seed oils AN - 17570797; 4783614 AB - We demonstrate that naturally occurring C sub(14) and C sub(16)-specific acyl-acyl carrier protein (ACP) desaturases from plants can complement the unsaturated fatty acid (UFA) auxotrophy of an Escherichia coli fabA/fadR mutant. Under the same growth conditions, C sub(18)-specific Delta super(9)- stearoyl (18:0)-ACP desaturases are unable to complement the UFA auxotrophy. This difference most likely results from the presence of sufficient substrate pools of C sub(14) and C sub(16) acyl-ACPs but a relative lack of C sub(18) acyl-ACP pools in E. coli to support the activities of the plant fatty acid desaturase. Based on this, a substrate- dependent selection system was devised with the use of the E. coli UFA auxotroph to isolate mutants of the castor Delta super(9)- 18:0-ACP desaturase that display enhanced specificity for C sub(14) and C sub(16) acyl-ACPs. Using this selection system, a number of desaturase variants with altered substrate specificities were isolated from pools of randomized mutants. These included several G188L mutant isolates, which displayed a 15-fold increase in specific activity with 16:0-ACP relative to the wild-type castor Delta super(9)- 18:0-ACP desaturase. Expression of this mutant in Arabidopsis thaliana resulted in the accumulation of unusual monounsaturated fatty acids to amounts of >25% of the seed oil. The bacterial selection system described here thus provides a rapid means of isolating variant fatty acid desaturase activities for modification of seed oil composition. JF - Proceedings of the National Academy of Sciences, USA AU - Cahoon, E B AU - Shanklin, J AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, shanklin@bnl.gov Y1 - 2000/10/24/ PY - 2000 DA - 2000 Oct 24 SP - 12350 EP - 12355 VL - 97 IS - 22 SN - 0027-8424, 0027-8424 KW - acyl carrier protein desaturase KW - metabolic engineering KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Seeds KW - Arabidopsis thaliana KW - Fatty acids KW - Oils KW - W2 32310:Enzymes and cofactors KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17570797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Substrate-dependent+mutant+complementation+to+select+fatty+acid+desaturase+variants+for+metabolic+engineering+of+plant+seed+oils&rft.au=Cahoon%2C+E+B%3BShanklin%2C+J&rft.aulast=Cahoon&rft.aufirst=E&rft.date=2000-10-24&rft.volume=97&rft.issue=22&rft.spage=12350&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.210276297 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Arabidopsis thaliana; Oils; Seeds; Fatty acids DO - http://dx.doi.org/10.1073/pnas.210276297 ER - TY - JOUR T1 - Structural Identification of a Key Protective B-cell Epitope in Lyme Disease Antigen OspA AN - 18424991; 5406468 AB - Outer surface protein A (OspA) is a major lipoprotein of the Borrelia burgdorferi spirochete, the causative agent of Lyme disease. Vaccination with OspA generates an immune response that can prevent bacterial transmission to a mammalian host during the attachment of an infected tick. However, the protective capacity of immune sera cannot be predicted by measuring total anti-OspA antibody. The murine monoclonal antibody LA-2 defines an important protective B-cell epitope of OspA against which protective sera have strong levels of reactivity. We have now mapped the LA-2 epitope of OspA using both NMR chemical-shift perturbation measurements in solution and X-ray crystal structure determination. LA-2 recognizes the three surface-exposed loops of the C-terminal domain of OspA that are on the tip of the elongated molecule most distant from the lipid-modified N terminus. The structure suggests that the natural variation at OspA sequence position 208 in the first loop is a major limiting factor for antibody cross-reactivity between different Lyme disease-causing Borrelia strains. The unusual Fab-dominated lattice of the crystal also permits a rare view of antigen flexibility within an antigen:antibody complex. These results provide a rationale for improvements in OspA-based vaccines and suggest possible designs for more direct tests of antibody protective levels in vaccinated individuals. Copyright 2000 Academic Press JF - Journal of Molecular Biology AU - Ding, Wei AU - Huang, Xiaolin AU - Yang, Xiaohua AU - Dunn, J J AU - Luft, B J AU - Koide, S AU - Lawson, CL AD - Biology Department, Brookhaven National Laboratory, Building 463, Upton, NY, 11973, USA, lawson@rutchem.rutgers.edu Y1 - 2000/10/06/ PY - 2000 DA - 2000 Oct 06 SP - 1153 EP - 1164 PB - Academic Press Ltd., 24-28 Oval Rd. London NW1 7DX UK, [mailto:apsubs@acad.com] VL - 302 IS - 5 SN - 0022-2836, 0022-2836 KW - OspA protein KW - Microbiology Abstracts B: Bacteriology KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18424991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Structural+Identification+of+a+Key+Protective+B-cell+Epitope+in+Lyme+Disease+Antigen+OspA&rft.au=Ding%2C+Wei%3BHuang%2C+Xiaolin%3BYang%2C+Xiaohua%3BDunn%2C+J+J%3BLuft%2C+B+J%3BKoide%2C+S%3BLawson%2C+CL&rft.aulast=Ding&rft.aufirst=Wei&rft.date=2000-10-06&rft.volume=302&rft.issue=5&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1006%2Fjmbi.2000.4119 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1006/jmbi.2000.4119 ER - TY - JOUR T1 - Oxygen detoxification in the strict anaerobic archaeon Archaeoglobus fulgidus: superoxide scavenging by Neelaredoxin AN - 17831904; 4866033 AB - Archaeoglobus fulgidus is a hyperthermophilic sulphate-reducing archaeon. It has an optimum growth temperature of 83 degree C and is described as a strict anaerobe. Its genome lacks any homologue of canonical superoxide (O. super(-)) dismutases. In this work, we show that neelaredoxin (Nlr) is the main O. super(-) scavenger in A. fulgidus, by studying both the wild-type and recombinant proteins. Nlr is a 125-amino-acid blue-coloured protein containing a single iron atom/molecule, which in the oxidized state is high spin ferric. This iron centre has a reduction potential of +230 mV at pH 7.0. Nitroblue tetrazolium-stained gel assays of cell-soluble extracts show that Nlr is the main protein from A. fulgidus which is reactive towards O. super(-). Furthermore, it is shown that Nlr is able to both reduce and dismutate O. super(-), thus having a bifunctional reactivity towards O. super(-). Kinetic and spectroscopic studies indicate that Nlr's superoxide reductase activity may allow the cell to eliminate O. super(-) quickly in a NAD(P)H-dependent pathway. On the other hand, Nlr's superoxide dismutation activity will allow the cell to detoxify O. super(-) independently of the cell redox status. Its superoxide dismutase activity was estimated to be 59 U mg super(-1) by the xanthine/xanthine oxidase assay at 25 degree C. Pulse radiolysis studies with the isolated and reduced Nlr proved unambiguously that it has superoxide dismutase activity; at pH 7.1 and 83 degree C, the rate constant is 5 x 10 super(6) M super(-1) s super(-1). Besides the superoxide dismutase activity, soluble cell extracts of A. fulgidus also exhibit catalase and NAD(P)H/oxygen oxidoreductase activities. By putting these findings together with the entire genomic data available, a possible oxygen detoxification mechanism in A. fulgidus is discussed. JF - Molecular Microbiology AU - Abreu, AI AU - Saraiva, M L AU - Carita, J AU - Huber, H AU - Stetter, OK AU - Cabelli, D AU - Teixeira, M AD - Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal. Lehrstuhl fuer Mikrobiologie der Universitaet Regensburg, 93053 Regensburg, Germany. Chemistry Department, Brookhaven National Laboratory, Upton, L. I. , NY 11973-5000, USA. Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 322 EP - 334 PB - Blackwell Science Ltd VL - 38 IS - 2 SN - 0950-382X, 0950-382X KW - Nlr protein KW - superoxide reductase KW - Microbiology Abstracts B: Bacteriology KW - Superoxide dismutase KW - Sulfate reduction KW - Archaeoglobus fulgidus KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17831904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Oxygen+detoxification+in+the+strict+anaerobic+archaeon+Archaeoglobus+fulgidus%3A+superoxide+scavenging+by+Neelaredoxin&rft.au=Abreu%2C+AI%3BSaraiva%2C+M+L%3BCarita%2C+J%3BHuber%2C+H%3BStetter%2C+OK%3BCabelli%2C+D%3BTeixeira%2C+M&rft.aulast=Abreu&rft.aufirst=AI&rft.date=2000-10-01&rft.volume=38&rft.issue=2&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Archaeoglobus fulgidus; Sulfate reduction; Superoxide dismutase ER - TY - JOUR T1 - Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes AN - 17722001; 4785781 AB - In previous studies cannabinoid agonists have been found to inhibit and cannabinoid antagonists to enhance electrically-evoked [ super(3)H]-acetycholine (ACh) release in hippocampal slices. The present study was undertaken to determine if similar cannabinoid effects could be observed in synaptosomes. [ super(3)H]-ACh release was evoked by two methods, both sensitive to presynaptic receptor effects. The first involved the addition of 1.3 mM calcium following perfusion with calcium-free Krebs and the second the addition of 11 mM potassium following perfusion with normal Krebs. In hippocampal synaptosomes the 1.3 mM calcium-evoked release and the high potassium-evoked [ super(3)H]-ACh release were inhibited by the cannabinoid agonist, WIN 55212-2, by 59 and 39%, respectively, and with an EC sub(50) of approximately 1 nM. WIN 55212-2 produced a similar, although less potent, inhibition of [ super(3)H]-ACh release in cortical synaptosomes. No inhibitory effect of WIN 55212-2 on [ super(3)H]-ACh release in striatal synaptosomes was observed, supporting previous data collected in this area with brain slices. The cannabinoid antagonist, SR 141716A, produced a robust enhancement of 1.3 mM calcium-evoked [ super(3)H]-ACh release in hippocampal synaptosomes (EC sub(50)<0.3 nM) but had no effect on potassium-evoked release or on [ super(3)H]-ACh release in the cortex or striatum. In conclusion our data demonstrates the inhibitory effects of WIN 55212-2 observed on ACh release in brain slices can be observed in hippocampal and cortex synaptosomes, suggesting a direct action of these compounds on the synaptic terminals. The SR 141716A-induced enhancement of ACh release can similarly be observed in hippocampal synaptosomes and is probably due to an inverse agonist action at constitutively active receptors. JF - British Journal of Pharmacology AU - Gifford, AN AU - Bruneus, M AU - Gatley, S J AU - Volkow, N D AD - Medical Department, Brookhaven National Laboratory, Upton, New York, NY 11973, USA, gifforda@bnl.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 645 EP - 650 VL - 131 IS - 3 SN - 0007-1188, 0007-1188 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Hippocampus KW - Synaptosomes KW - Brain KW - Cortex KW - Cannabinoids KW - Acetylcholine KW - X 24180:Social poisons & drug abuse KW - N3 11091:Vertebrate Nervous Systems: General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17722001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Pharmacology&rft.atitle=Cannabinoid+receptor-mediated+inhibition+of+acetylcholine+release+from+hippocampal+and+cortical+synaptosomes&rft.au=Gifford%2C+AN%3BBruneus%2C+M%3BGatley%2C+S+J%3BVolkow%2C+N+D&rft.aulast=Gifford&rft.aufirst=AN&rft.date=2000-10-01&rft.volume=131&rft.issue=3&rft.spage=645&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Pharmacology&rft.issn=00071188&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cortex; Acetylcholine; Synaptosomes; Hippocampus; Brain; Cannabinoids ER - TY - JOUR T1 - 1999 site environmental report AN - 51310158; 2008-004785 JF - BNL (Brookhaven National Laboratory) Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 297 PB - Brookhaven National Laboratory, Associated Universities, Upton, NY SN - 0197-8659, 0197-8659 KW - United States KW - aquifer vulnerability KW - Brookhaven National Laboratory KW - regulations KW - annual report KW - ecosystems KW - environmental analysis KW - radioactive waste KW - ground water KW - Suffolk County New York KW - environmental management KW - waste management KW - report KW - ecology KW - programs KW - monitoring KW - pollution KW - migration of elements KW - research KW - preventive measures KW - aquifers KW - New York KW - risk assessment KW - nuclear facilities KW - waste disposal KW - water resources KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51310158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2000-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=1999+site+environmental+report&rft.title=1999+site+environmental+report&rft.issn=01978659&rft_id=info:doi/ L2 - http://www.osti.gov/bridge/servlets/purl/770705-EWEkht/770705.PDF LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - PubXState - NY N1 - Document feature - illus. incl. 63 tables, sketch maps N1 - SuppNotes - Includes appendices N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - annual report; aquifer vulnerability; aquifers; Brookhaven National Laboratory; ecology; ecosystems; environmental analysis; environmental management; ground water; migration of elements; monitoring; New York; nuclear facilities; pollution; preventive measures; programs; radioactive waste; regulations; report; research; risk assessment; Suffolk County New York; United States; waste disposal; waste management; water resources ER - TY - JOUR T1 - Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B. AN - 71751157; 10932256 AB - Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its catalytic and binding sites. The position of the belt region in BoNT/B is different from that in BoNT/A; this observation presents interesting possibilities for designing specific inhibitors that could be used to block the activity of this neurotoxin. The structures of BoNT/B and its complex with sialyllactose provide a detailed description of the active site and a model for interactions between the toxin and its cell surface receptor. The latter may provide valuable information for recombinant vaccine development. JF - Nature structural biology AU - Swaminathan, S AU - Eswaramoorthy, S AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. swami@bnl.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 693 EP - 699 VL - 7 IS - 8 SN - 1072-8368, 1072-8368 KW - Gangliosides KW - 0 KW - Receptors, Cell Surface KW - Sialic Acids KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - N-acetylneuraminoyllactose KW - 3J7TAL60G3 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Lactose KW - J2B2A4N98G KW - Index Medicus KW - Lactose -- chemistry KW - Sialic Acids -- chemistry KW - Protein Structure, Secondary KW - Lactose -- metabolism KW - Models, Molecular KW - Amino Acid Sequence KW - Sialic Acids -- metabolism KW - Receptors, Cell Surface -- chemistry KW - Binding Sites KW - Botulinum Toxins, Type A -- chemistry KW - Receptors, Cell Surface -- metabolism KW - Sequence Alignment KW - Lactose -- analogs & derivatives KW - Molecular Sequence Data KW - Botulinum Toxins, Type A -- metabolism KW - Crystallography, X-Ray KW - Protein Structure, Tertiary KW - Gangliosides -- metabolism KW - Catalytic Domain KW - Botulinum Toxins -- chemistry KW - Botulinum Toxins -- metabolism KW - Clostridium botulinum -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71751157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+structural+biology&rft.atitle=Structural+analysis+of+the+catalytic+and+binding+sites+of+Clostridium+botulinum+neurotoxin+B.&rft.au=Swaminathan%2C+S%3BEswaramoorthy%2C+S&rft.aulast=Swaminathan&rft.aufirst=S&rft.date=2000-08-01&rft.volume=7&rft.issue=8&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Nature+structural+biology&rft.issn=10728368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-24 N1 - Date created - 2000-08-24 N1 - Date revised - 2017-02-17 N1 - Genetic sequence - 1F31; PDB; 1EPW N1 - SuppNotes - Comment In: Nat Struct Biol. 2000 Aug;7(8):617-9 [10932240] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Crystallization and preliminary X-ray analysis of Clostridium botulinum neurotoxin type B. AN - 71749375; 10944343 AB - Single crystals of Clostridium botulinum neurotoxin type B have been obtained by the vapor-diffusion method. These crystals belong to space group P2(1), with unit-cell parameters a = 76.08, b = 123.11, c = 95.86 A, beta = 113.03 degrees and diffract to at least 1.8 A resolution. Native data have been collected from flash-frozen crystals at the National Synchrotron facility of Brookhaven National Laboratory. These crystals often tend to be non-isomorphic. JF - Acta crystallographica. Section D, Biological crystallography AU - Swaminathan, S AU - Eswaramoorthy, S AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. swami@bnl.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 1024 EP - 1026 VL - 56 SN - 0907-4449, 0907-4449 KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Index Medicus KW - Crystallization KW - Crystallography, X-Ray KW - Clostridium botulinum -- chemistry KW - Botulinum Toxins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71749375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.atitle=Crystallization+and+preliminary+X-ray+analysis+of+Clostridium+botulinum+neurotoxin+type+B.&rft.au=Swaminathan%2C+S%3BEswaramoorthy%2C+S&rft.aulast=Swaminathan&rft.aufirst=S&rft.date=2000-08-01&rft.volume=56&rft.issue=&rft.spage=1024&rft.isbn=&rft.btitle=&rft.title=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.issn=09074449&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-23 N1 - Date created - 2000-10-23 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - PET studies of the effects of aerobic exercise on human striatal dopamine release. AN - 18155593; 4866977 AB - In vivo microdialysis studies have shown that exercise increases the concentration of dopamine (DA) in the striatum of the rat brain. It has also been shown that PET with [11Craclopride can be used to assess changes in brain DA induced by drugs and by performance tasks such as playing a video game. The purpose of this study was to evaluate the effects of exercise (treadmill running) on striatal DA release in the human brain. METHODS: Twelve healthy volunteers (5 women, 7 men; mean age, 32 +/- 5 y; age range, 25-40 y) with a history of regular exercise received 2 PET scans with [11Craclopride on 2 separate days, 1 at baseline and 1 at 5-10 min after running on a treadmill for 30 min. The speed and inclination of the treadmill were increased gradually to reach a maximal speed of 9.7 km/h (6 mph) and a maximal inclination of 10degrees. Data were acquired on a Siemens HR+ scanner in 3-dimensional mode for 60 min. Heart rates and electrocardiograms were monitored. DA D2 receptor availability was measured using the ratio of the distribution volume in the putamen to that in the cerebellum, which is a function of the number of available binding sites/dissociation constant. RESULTS: The subjects ran at an average speed of 8.7 +/- 0.5 km/h (5.4 +/- 0.3 mph) and at an inclination of 3.3degrees +/- 2degrees. The maximum effort of running was maintained for 10-15 min. The heart rates of the subjects were increased by 143% +/- 47%. DA D2 receptor availability in the putamen after treadmill running (4.22 +/- 0.34) was no different from that of baseline (4.17 +/- 0.29; P < 0.6). CONCLUSION: No significant changes in synaptic DA concentration were detected, although the subjects exercised vigorously for 30 min. JF - Journal of Nuclear Medicine AU - Wang, G J AU - Volkow, N D AU - Fowler, J S AU - Franceschi, D AU - Logan, J AU - Pappas, N R AU - Wong, C T AU - Netusil, N AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 1352 EP - 1356 VL - 41 IS - 8 SN - 0161-5505, 0161-5505 KW - Physical Education Index KW - Exercise physiology KW - Exercise (mode) KW - Exercise (intensity) KW - Muscles (exercise effects) KW - Human subjects KW - Brain KW - Running (runners) KW - Aerobic capacity KW - Sports medicine KW - Treadmill ergometry KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18155593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=PET+studies+of+the+effects+of+aerobic+exercise+on+human+striatal+dopamine+release.&rft.au=Wang%2C+G+J%3BVolkow%2C+N+D%3BFowler%2C+J+S%3BFranceschi%2C+D%3BLogan%2C+J%3BPappas%2C+N+R%3BWong%2C+C+T%3BNetusil%2C+N&rft.aulast=Wang&rft.aufirst=G&rft.date=2000-08-01&rft.volume=41&rft.issue=8&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Sports medicine; Exercise physiology; Aerobic capacity; Exercise (mode); Muscles (exercise effects); Treadmill ergometry; Running (runners); Human subjects; Brain; Exercise (intensity) ER - TY - JOUR T1 - Clustered damages and total lesions induced in DNA by ionizing radiation: oxidized bases and strand breaks. AN - 71226847; 10891084 AB - Ionizing radiation induces both isolated DNA lesions and clustered damages-multiple closely spaced lesions (strand breaks, oxidized purines, oxidized pyrimidines, or abasic sites within a few helical turns). Such clusters are postulated to be difficult to repair and thus potentially lethal or mutagenic lesions. Using highly purified enzymes that cleave DNA at specific classes of damage and electrophoretic assays developed for quantifying isolated and clustered damages in high molecular length genomic DNAs, we determined the relative frequencies of total lesions and of clustered damages involving both strands, and the composition and origin of such clusters. The relative frequency of isolated vs clustered damages depends on the identity of the lesion, with approximately 15-18% of oxidized purines, pyrimidines, or abasic sites in clusters recognized by Fpg, Nth, or Nfo proteins, respectively, but only about half that level of frank single strand breaks in double strand breaks. Oxidized base clusters and abasic site clusters constitute about 80% of complex damages, while double strand breaks comprise only approximately 20% of the total. The data also show that each cluster results from a single radiation (track) event, and thus clusters will be formed at low as well as high radiation doses. JF - Biochemistry AU - Sutherland, B M AU - Bennett, P V AU - Sidorkina, O AU - Laval, J AD - Biology Department, Building 463, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. bms@bnl.gov Y1 - 2000/07/11/ PY - 2000 DA - 2000 Jul 11 SP - 8026 EP - 8031 VL - 39 IS - 27 SN - 0006-2960, 0006-2960 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Oxidation-Reduction KW - Gamma Rays KW - DNA Damage KW - DNA -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71226847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Clustered+damages+and+total+lesions+induced+in+DNA+by+ionizing+radiation%3A+oxidized+bases+and+strand+breaks.&rft.au=Sutherland%2C+B+M%3BBennett%2C+P+V%3BSidorkina%2C+O%3BLaval%2C+J&rft.aulast=Sutherland&rft.aufirst=B&rft.date=2000-07-11&rft.volume=39&rft.issue=27&rft.spage=8026&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-04 N1 - Date created - 2000-08-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - A new Klebsiella planticola strain (Cd-1) grows anaerobically at high cadmium concentrations and precipitates cadmium sulfide AN - 17652685; 4747693 AB - Heavy metal resistance by bacteria is a topic of much importance to the bioremediation of contaminated soils and sediments. We report here the isolation of a highly cadmium-resistant Klebsiella planticola strain, Cd-1, from reducing salt marsh sediments. The strain grows in up to 15 mM CdCl sub(2) under a wide range of NaCl concentrations and at acidic or neutral pH. In growth medium amended with thiosulfate, it precipitated significant amounts of cadmium sulfide (CdS), as confirmed by x-absorption spectroscopy. In comparison with various other strains tested, Cd-1 is superior for precipitating CdS in cultures containing thiosulfate. Thus, our results suggest that Cd-1 is a good candidate for the accelerated bioremediation of systems contaminated by high levels of cadmium. JF - Applied and Environmental Microbiology AU - Sharma, P K AU - Balkwill, D L AU - Frenkel, A AU - Vairavamurthy, MA AD - Department of Applied Science, Brookhaven National Laboratory, Bldg. 815, Upton, NY 11973, USA, vmurthy@bnl.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 3083 EP - 3087 VL - 66 IS - 7 SN - 0099-2240, 0099-2240 KW - cadmium sulfide KW - thiosulfate KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bioremediation KW - Heavy metals KW - Klebsiella planticola KW - Cadmium KW - Anaerobic conditions KW - A 01116:Bacteria KW - W2 32510:Waste treatment, environment, pollution KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17652685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=A+new+Klebsiella+planticola+strain+%28Cd-1%29+grows+anaerobically+at+high+cadmium+concentrations+and+precipitates+cadmium+sulfide&rft.au=Sharma%2C+P+K%3BBalkwill%2C+D+L%3BFrenkel%2C+A%3BVairavamurthy%2C+MA&rft.aulast=Sharma&rft.aufirst=P&rft.date=2000-07-01&rft.volume=66&rft.issue=7&rft.spage=3083&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.66.7.3083-3087.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Klebsiella planticola; Anaerobic conditions; Cadmium; Heavy metals; Bioremediation DO - http://dx.doi.org/10.1128/AEM.66.7.3083-3087.2000 ER - TY - JOUR T1 - 4.0 T water proton T1 relaxation times in normal human brain and during acute ethanol intoxication. AN - 71242367; 10888071 AB - BACKGROUNDIt has been reported that acute ethanol intoxication decreases the brain water proton magnetic resonance T1 values, an effect that has been interpreted to indicate brain dehydration during this condition. Because water macromolecular interactions largely determine tissue water T1, another possible explanation for reduced brain water proton T1 values is that the interaction between water and brain macromolecules is altered by ethanol.METHODSA 4.0 T magnetic resonance imaging (MRI) instrument was used to measure brain water proton T1 relaxation times before, during, and after ethanol intoxication (dose, 0.75 mg/kg) in healthy controls.RESULTSThe T1 relaxation times as assessed with MRI were highly reproducible. The mean, paired ethanol-induced differences in T1 were -0.004 +/- 0.007 sec (mean +/- standard deviation) for white matter and 0.010 +/- 0.015 sec for internal gray matter structures, neither of which was significant.CONCLUSIONSThis reasonably sensitive measurement does not support the view that tissue water content or water macromolecule interactions are significantly altered in the brain during acute alcohol intoxication in otherwise healthy subjects. JF - Alcoholism, clinical and experimental research AU - Rooney, W D AU - Lee, J H AU - Li, X AU - Wang, G J AU - Franceschi, D AU - Springer, C S AU - Volkow, N D AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 830 EP - 836 VL - 24 IS - 6 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - Protons KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Affect -- drug effects KW - Cognition -- drug effects KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Magnetic Resonance Imaging KW - Body Water -- drug effects KW - Central Nervous System Depressants -- pharmacology KW - Ethanol -- pharmacology KW - Brain -- drug effects KW - Body Water -- metabolism KW - Alcoholic Intoxication -- blood KW - Brain -- metabolism KW - Alcoholic Intoxication -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71242367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=4.0+T+water+proton+T1+relaxation+times+in+normal+human+brain+and+during+acute+ethanol+intoxication.&rft.au=Rooney%2C+W+D%3BLee%2C+J+H%3BLi%2C+X%3BWang%2C+G+J%3BFranceschi%2C+D%3BSpringer%2C+C+S%3BVolkow%2C+N+D&rft.aulast=Rooney&rft.aufirst=W&rft.date=2000-06-01&rft.volume=24&rft.issue=6&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-07 N1 - Date created - 2000-11-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Regional brain metabolism during alcohol intoxication. AN - 71240986; 10888070 AB - BACKGROUNDEthanol has a broad range of actions on many neurotransmitter systems. The depressant actions of ethanol in the brain are related in part to facilitation of gamma-aminobutyric acid (GABA) neurotransmission via its interaction with the benzodiazepine/GABA receptor complex. The purpose of this study was to evaluate the effects of ethanol on regional brain metabolism in 10 healthy right-handed men. The results were compared with those we previously published in a different group of 16 normal male subjects who received intravenous lorazepam, a benzodiazepine drug that also enhances GABA neurotransmission.METHODSThe subjects were scanned with positron emission tomography and [F-18] fluorodeoxyglucose twice: 40 min after the end of placebo (diet soda) or ethanol (0.75 g/kg) oral administration. Image data sets were analyzed by using both the region of interest and the statistical parametric mapping (SPM) approach. SPM was used to generate a difference image between baseline and ethanol, which we compared to the difference image between baseline and lorazepam (30 microg/kg).RESULTSEthanol significantly increased self-reports of "high" (p < or = 0.0001), dizziness (p < or = 0.004), and intoxication (p < or = 0.0001). Ethanol significantly decreased whole brain (-25 +/- 6%, p < or = 0.0001) and regional metabolism. Normalization of the regional measures by whole brain metabolism (relative measures) showed that ethanol decreased relative metabolic activity in occipital cortex (-4.9 +/- 4.1%, p < or = 0.006), whereas it increased relative metabolic act in left temporal cortex (+3.5 +/- 2.9%, p < or = 0.006) and left basal ganglia (+9 +/- 6.3%, p < or = 0.0009). SPM analyses revealed the same pattern of responses as the relative measures, showing decreases in occipital cortex and increases in left temporal cortex. Comparison of the relative measures and the SPM analyses obtained with lorazepam data revealed a similar pattern of effects, with relative decreases in occipital cortex (-7.8 +/- 4.8%) and relative increases in left temporal cortex (+3.8 +/- 5.7%). Lorazepam, but not ethanol, also decreased thalamic metabolism (-11.2 +/- 7.2%).CONCLUSIONSThese results support similar though not identical mechanisms for the effects of alcohol and benzodiazepines on brain glucose metabolism. The fact that lorazepam, but not alcohol, reduced thalamic metabolism, an effect associated with sleepiness, could explain the higher sedative effects of lorazepam than of alcohol. JF - Alcoholism, clinical and experimental research AU - Wang, G J AU - Volkow, N D AU - Franceschi, D AU - Fowler, J S AU - Thanos, P K AU - Scherbaum, N AU - Pappas, N AU - Wong, C T AU - Hitzemann, R J AU - Felder, C A AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. gjwang@bnl.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 822 EP - 829 VL - 24 IS - 6 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - GABA Modulators KW - Placebos KW - Ethanol KW - 3K9958V90M KW - Lorazepam KW - O26FZP769L KW - Index Medicus KW - Brain Mapping KW - Affect -- drug effects KW - Humans KW - GABA Modulators -- pharmacology KW - Adult KW - Tomography, Emission-Computed KW - Middle Aged KW - Male KW - Lorazepam -- pharmacology KW - Alcoholic Intoxication -- diagnostic imaging KW - Central Nervous System Depressants -- pharmacology KW - Ethanol -- pharmacology KW - Brain -- drug effects KW - Brain -- metabolism KW - Brain -- diagnostic imaging KW - Alcoholic Intoxication -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71240986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Regional+brain+metabolism+during+alcohol+intoxication.&rft.au=Wang%2C+G+J%3BVolkow%2C+N+D%3BFranceschi%2C+D%3BFowler%2C+J+S%3BThanos%2C+P+K%3BScherbaum%2C+N%3BPappas%2C+N%3BWong%2C+C+T%3BHitzemann%2C+R+J%3BFelder%2C+C+A&rft.aulast=Wang&rft.aufirst=G&rft.date=2000-06-01&rft.volume=24&rft.issue=6&rft.spage=822&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-07 N1 - Date created - 2000-11-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The complete optical spectrum of liquid water measured by inelastic X-ray scattering AN - 50114464; 2009-098580 AB - Interaction of light with matter is of paramount importance in nature. The most fundamental property of a material in relation to light is its oscillator strength distribution, i.e., how strongly it absorbs light as a function of wavelength. Once the oscillator strength distribution is determined precisely for a wide enough energy range, the optical constants such as absorbance and reflectance as well as a number of other properties of the material, some of which are seemingly unrelated to photoabsorption, can be deduced. Most important of all is the fact that the interaction of matter with fast charged particles can be described by its complete optical spectra [Inokuti, M. (1986) Photochem. Photobiol. 44, 279-285]. Despite their importance, however, the complete optical spectra of volatile liquids including water have never been obtained accurately because of experimental difficulties inherent in vacuum UV spectroscopy. Inelastic X-ray scattering spectroscopy can provide quantitative data equivalent to those from vacuum UV absorption spectra. Herein, we show the complete optical spectrum of liquid water determined by making use of intense monochromatic X-rays supplied by the wiggler line X21 of the National Synchrotron Light Source. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Hayashi, Hisashi AU - Watanabe, Noboru AU - Udagawa, Yasuo AU - Kao, C C Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 6264 EP - 6266 PB - National Academy of Sciences, Washington, DC VL - 97 IS - 12 SN - 0027-8424, 0027-8424 KW - water KW - liquid phase KW - chemical analysis KW - optical spectra KW - refraction KW - hydrochemistry KW - measurement KW - dielectric properties KW - X-ray spectroscopy KW - X-ray analysis KW - inelastic X-ray scattering spectroscopy KW - applications KW - spectra KW - spectroscopy KW - geochemistry KW - 21:Hydrogeology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50114464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=The+complete+optical+spectrum+of+liquid+water+measured+by+inelastic+X-ray+scattering&rft.au=Hayashi%2C+Hisashi%3BWatanabe%2C+Noboru%3BUdagawa%2C+Yasuo%3BKao%2C+C+C&rft.aulast=Hayashi&rft.aufirst=Hisashi&rft.date=2000-06-01&rft.volume=97&rft.issue=12&rft.spage=6264&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.110572097 L2 - http://www.pnas.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Number of references - 20 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - PNASA6 N1 - SubjectsTermNotLitGenreText - applications; chemical analysis; dielectric properties; geochemistry; hydrochemistry; inelastic X-ray scattering spectroscopy; liquid phase; measurement; optical spectra; refraction; spectra; spectroscopy; water; X-ray analysis; X-ray spectroscopy DO - http://dx.doi.org/10.1073/pnas.110572097 ER - TY - JOUR T1 - Exploring the possibilities presented by protein engineering AN - 17661997; 4718043 AB - A combination of classical and powerful new combinatorial genetic techniques allows the redesign of enzyme activities and creation of proteins that are tailored to have specific properties. These technologies have far-reaching consequences for the future design of crop plants and the storage compounds within them. JF - Current Opinion in Plant Biology AU - Shanklin, J AD - Department of Biology, Building 463, 50 Bell Avenue, Brookhaven National Laboratory, Upton, New York 11786, USA, shanklin@bnl.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 243 EP - 248 VL - 3 IS - 3 SN - 1369-5266, 1369-5266 KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Storage KW - Protein engineering KW - Reviews KW - Plants KW - combinatorial chemistry KW - Crops KW - W2 32000:General topics and reviews KW - W2 32340:Other peptides, proteins, amino acids KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17661997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Plant+Biology&rft.atitle=Exploring+the+possibilities+presented+by+protein+engineering&rft.au=Shanklin%2C+J&rft.aulast=Shanklin&rft.aufirst=J&rft.date=2000-06-01&rft.volume=3&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Plant+Biology&rft.issn=13695266&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Protein engineering; combinatorial chemistry; Crops; Storage; Plants; Reviews ER - TY - JOUR T1 - Tolerance of the normal canine brain to epithermal neutron irradiation in the presence of p-boronophenylalanine. AN - 72317475; 11026694 AB - Twelve normal dogs underwent brain irradiation in a mixed-radiation, mainly epithermal neutron field at the Brookhaven Medical Research Reactor following intravenous infusion of 950 mg of 10B-enriched BPA/kg as its fructose complex. The 5 x 10 cm irradiation aperture was centered over the left hemisphere. For a subgroup of dogs reported previously, we now present more detailed analyses including dose-volume relationships, longer follow-ups, MRIs, and histopathological observations. Peak doses (delivered to 1 cm3 of brain at the depth of maximum thermal neutron flux) ranged from 7.6 Gy (photon-equivalent dose: 11.8 Gy-Eq) to 11.6 Gy (17.5 Gy-Eq). The average dose to the brain ranged from 3.0 Gy (4.5 Gy-Eq) to 8.1 Gy (11.9 Gy-Eq) and to the left hemisphere, 6.6 Gy (10.1 Gy-Eq) to 10.0 Gy (15.0 Gy-Eq). Maximum tolerated 'threshold' doses were 6.7 Gy (9.8 Gy-Eq) to the whole brain and 8.2 Gy (12.3 Gy-Eq) to one hemisphere. The threshold peak brain dose was 9.5 Gy (14.3 Gy-Eq). At doses below threshold, some dogs developed subclinical MRI changes. Above threshold, all dogs developed dose-dependent MRI changes, neurological deficits, and focal brain necrosis. JF - Journal of neuro-oncology AU - Coderre, J A AU - Gavin, P R AU - Capala, J AU - Ma, R AU - Morris, G M AU - Button, T M AU - Aziz, T AU - Peress, N S AD - Medical Department, Brookhaven National Laboratory, Upton, NY, USA. coderre@bnl.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 27 EP - 40 VL - 48 IS - 1 SN - 0167-594X, 0167-594X KW - Boron Compounds KW - 0 KW - Radiation-Sensitizing Agents KW - Phenylalanine KW - 47E5O17Y3R KW - 4-boronophenylalanine KW - UID84303EL KW - Index Medicus KW - Neutrons KW - Magnetic Resonance Imaging KW - Radiation Dosage KW - Lymphocyte Count KW - Animals KW - Muscle, Skeletal -- radiation effects KW - Scalp -- radiation effects KW - Dogs KW - Platelet Count KW - Phenylalanine -- analogs & derivatives KW - Boron Compounds -- pharmacology KW - Radiation-Sensitizing Agents -- pharmacology KW - Phenylalanine -- pharmacology KW - Brain -- radiation effects KW - Brain -- pathology KW - Brain -- drug effects KW - Boron Neutron Capture Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72317475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuro-oncology&rft.atitle=Tolerance+of+the+normal+canine+brain+to+epithermal+neutron+irradiation+in+the+presence+of+p-boronophenylalanine.&rft.au=Coderre%2C+J+A%3BGavin%2C+P+R%3BCapala%2C+J%3BMa%2C+R%3BMorris%2C+G+M%3BButton%2C+T+M%3BAziz%2C+T%3BPeress%2C+N+S&rft.aulast=Coderre&rft.aufirst=J&rft.date=2000-05-01&rft.volume=48&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuro-oncology&rft.issn=0167594X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Synthesis and evaluation of 6-[(18)F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine as a PET tracer for nicotinic acetylcholine receptors. AN - 71741543; 10938474 AB - Both ABT-594 ((R)-2-chloro-5-(2-azetidinylmethoxy)pyridine) and A-85380 (3-[2(S)-2-azetidinylmethoxy]pyridine), novel nicotinic agonists that possess potent non-opioid analgesic properties, have high affinity for neuronal nicotinic acetylcholine receptors (nAChR) but do not elicit the pronounced toxicity of epibatidine. 6-[(18)F]Fluoro-3-(2(S)-azetidinylmethoxy)pyridine (6-[(18)F]fluoro-A-85380), a F-18 labeled analogue of these two compounds, is therefore a promising radioligand for positron emission tomography (PET) studies in humans. The use of trimethylammonium as a leaving group in nucleophilic aromatic substitution reactions has proven to be a versatile and efficient strategy, and offers several advantages over other leaving groups. Here, we report the synthetic strategy for the preparation of a precursor, as a trimethylammonium iodide salt, and its use in the radiosynthesis to 6-[(18)F]fluoro-A-85380. Preliminary compartative PET studies of 6-[(18)F]fluoro-A-85380 and 2-[(18)F]fluoro-A-85380 were carried out in baboon to examine their suitability as tracers for studying nAChR system. JF - Nuclear medicine and biology AU - Ding, Y AU - Liu, N AU - Wang, T AU - Marecek, J AU - Garza, V AU - Ojima, I AU - Fowler, J S AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY, USA. ding@bnl.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 381 EP - 389 VL - 27 IS - 4 SN - 0969-8051, 0969-8051 KW - 5-(2-azetidinylmethoxy)-2-chloropyridine KW - 0 KW - A 85380 KW - Azetidines KW - Fluorine Radioisotopes KW - Pyridines KW - Receptors, Nicotinic KW - Index Medicus KW - Papio KW - Animals KW - Isotope Labeling KW - Female KW - Azetidines -- metabolism KW - Receptors, Nicotinic -- analysis KW - Tomography, Emission-Computed KW - Pyridines -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71741543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+medicine+and+biology&rft.atitle=Synthesis+and+evaluation+of+6-%5B%2818%29F%5Dfluoro-3-%282%28S%29-azetidinylmethoxy%29pyridine+as+a+PET+tracer+for+nicotinic+acetylcholine+receptors.&rft.au=Ding%2C+Y%3BLiu%2C+N%3BWang%2C+T%3BMarecek%2C+J%3BGarza%2C+V%3BOjima%2C+I%3BFowler%2C+J+S&rft.aulast=Ding&rft.aufirst=Y&rft.date=2000-05-01&rft.volume=27&rft.issue=4&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Nuclear+medicine+and+biology&rft.issn=09698051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-26 N1 - Date created - 2000-10-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The interaction of hydrophilic thiols with cadmium; investigation with a simple model, 3-mercaptopropionic acid AN - 52223162; 2001-042619 AB - Environmental contamination by cadmium is widely recognized as a serious problem. All cadmium compounds are considered toxic and are regulated by the US Environmental Protection Agency. In organisms, thiols or organic sulfhydryl compounds are primarily involved in mobilizing and detoxifying cadmium through the formation of cadmium-thiol complexes inside the cell. This complexation is also of environmental importance because a variety of thiols are generated by biotic and abiotic processes in anaerobic environments, such as estuarine wetlands and coastal sediments, which have increasingly become the targets of metal pollution. We investigated the complexation of cadmium by 3-mercaptopropionic acid (MPA), using it as a simple model to better understand the potential pathways of cadmium transformations by hydrophilic thiols. Our results show that cadmium forms primarily 1:1 and 1:2 complexes with MPA in aqueous solutions at near-neutral pH values. While the dithio complex was highly soluble in water, the monothio complex rapidly precipitated from solution. Based on mass spectrometric and X-ray absorption spectroscopic data, we propose a cyclic, charge-neutralized structure for the monothio complex, and a linear ionic structure for the dithio complex. These results suggest that the type of complex formed is an important determinant of the mobility of cadmium. JF - Marine Chemistry AU - Vairavamurthy, Murthy A AU - Goldenberg, Wayne S AU - Ouyang, Shi AU - Khalid, Syed A2 - Sharma, Virender K. Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 181 EP - 189 PB - Elsevier, Amsterdam VL - 70 IS - 1-3 SN - 0304-4203, 0304-4203 KW - experimental studies KW - biochemistry KW - electrochemical properties KW - models KW - hydrophilic thiols KW - organic compounds KW - organic acids KW - metals KW - bacteria KW - chemical properties KW - cadmium KW - oxides KW - mercaptopropionic acid KW - reduction KW - geochemistry KW - electrons KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52223162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Chemistry&rft.atitle=The+interaction+of+hydrophilic+thiols+with+cadmium%3B+investigation+with+a+simple+model%2C+3-mercaptopropionic+acid&rft.au=Vairavamurthy%2C+Murthy+A%3BGoldenberg%2C+Wayne+S%3BOuyang%2C+Shi%3BKhalid%2C+Syed&rft.aulast=Vairavamurthy&rft.aufirst=Murthy&rft.date=2000-05-01&rft.volume=70&rft.issue=1-3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Marine+Chemistry&rft.issn=03044203&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/03044203 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2001-01-01 N1 - Number of references - 23 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - MRCHBD N1 - SubjectsTermNotLitGenreText - bacteria; biochemistry; cadmium; chemical properties; electrochemical properties; electrons; experimental studies; geochemistry; hydrophilic thiols; mercaptopropionic acid; metals; models; organic acids; organic compounds; oxides; reduction ER - TY - JOUR T1 - Surface speciation of calcite observed in situ by high-resolution X-ray reflectivity AN - 52367018; 2000-030591 AB - In situ specular X-ray reflectivity measurements are presented of the calcite (104)-water interface in calcite-saturated aqueous solutions at pH 6.8-12.1 and low PCO (sub 2) , and the sensitivity of these high-resolution measurements is demonstrated to detect variations in surface speciation. The data predict CaOH (super +) (sub 2) species at the calcite surface over a wide range of pH, but did not detect a significant coverage of CO (sub 3) Ca (super +) species predicted by van Capellen et al., suggesting that the surface charge on calcite is accommodated mainly by protonation reactions under these experimental conditions. JF - Geochimica et Cosmochimica Acta AU - Fenter, P AU - Geissbuehler, P AU - DiMasi, E AU - Srajer, G AU - Sorensen, L B AU - Sturchio, N C Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 1221 EP - 1228 PB - Pergamon, Oxford VL - 64 IS - 7 SN - 0016-7037, 0016-7037 KW - calcium KW - high-resolution methods KW - alkaline earth metals KW - experimental studies KW - carbonate ion KW - in situ KW - complexing KW - mineral-water interface KW - ions KW - X-ray spectra KW - calcite KW - chemical reactions KW - metals KW - spectra KW - reflectance KW - carbonates KW - pH KW - chemical fractionation KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52367018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Surface+speciation+of+calcite+observed+in+situ+by+high-resolution+X-ray+reflectivity&rft.au=Fenter%2C+P%3BGeissbuehler%2C+P%3BDiMasi%2C+E%3BSrajer%2C+G%3BSorensen%2C+L+B%3BSturchio%2C+N+C&rft.aulast=Fenter&rft.aufirst=P&rft.date=2000-04-01&rft.volume=64&rft.issue=7&rft.spage=1221&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2FS0016-7037%2899%2900403-2 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 2000-01-01 N1 - Number of references - 45 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - alkaline earth metals; calcite; calcium; carbonate ion; carbonates; chemical fractionation; chemical reactions; complexing; experimental studies; high-resolution methods; in situ; ions; metals; mineral-water interface; pH; reflectance; spectra; X-ray spectra DO - http://dx.doi.org/10.1016/S0016-7037(99)00403-2 ER - TY - JOUR T1 - Oxidation of {100} and {111} surfaces of pyrite; effects of preparation method AN - 52362854; 2000-034019 AB - Photoelectron spectroscopy was used to investigate the surface structure and reactivity of two pyrite {100} surfaces, prepared by different means. Specifically, synchrotron-based S 2p photoemission data for a {100} pyrite growth surface prepared by exposure to HCl, and one resulting from mechanical fracture suggested that the acid-washed growth surface showed a higher concentration of elemental sulfur and/or polysulfide impurities. The surfaces, however, showed a similar initial oxidation reactivity under a well-controlled H (sub 2) O/O (sub 2) gaseous environment, implying that the fraction of both surfaces that underwent the initial oxidation reaction were similar in structure. The amount of initial oxidation on these surfaces, however, was significantly lower than on an acid-washed {111} growth surface. Photoelectron and ion scattering spectroscopy offer some possible reasons for this structure sensitivity. JF - American Mineralogist AU - Elsetinow, Alicia R AU - Guevremont, Jeffrey M AU - Strongin, Daniel R AU - Schoonen, Martin A A AU - Strongin, Myron Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 623 EP - 626 PB - Mineralogical Society of America, Washington, DC VL - 85 IS - 3-4 SN - 0003-004X, 0003-004X KW - synchrotron radiation KW - surface properties KW - oxidation KW - photoelectron spectra KW - pyrite KW - crystal structure KW - sulfides KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52362854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Oxidation+of+%7B100%7D+and+%7B111%7D+surfaces+of+pyrite%3B+effects+of+preparation+method&rft.au=Elsetinow%2C+Alicia+R%3BGuevremont%2C+Jeffrey+M%3BStrongin%2C+Daniel+R%3BSchoonen%2C+Martin+A+A%3BStrongin%2C+Myron&rft.aulast=Elsetinow&rft.aufirst=Alicia&rft.date=2000-04-01&rft.volume=85&rft.issue=3-4&rft.spage=623&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 12 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - crystal structure; oxidation; photoelectron spectra; pyrite; sulfides; surface properties; synchrotron radiation ER - TY - JOUR T1 - Biological Augmentation Eliminates Grease and Oil in Bakery Wastewater AN - 17545460; 4725684 AB - The feasibility of a biological augmentation approach to eliminate oil and grease in the wastewater of a large bakery was evaluated and experimentally tested. The approach, based on approximation of a treatment tank with a model of a continuous culture of bacteria (chemostat), was evaluated first. Bacteria appropriate for use in biological augmentation were selected according to theoretical requirements. Results of subsequent field tests corresponded fairly well to predicted values, although oil and grease content in the outflow was still greater than the allowable level. To further increase cell concentration in the treatment tank, a solid support for bacterial growth, a biological filter, was added next and was successful. As a result, a bioremediation scheme was devised that included pH adjustment and mixing-aeration systems, an external biological reactor system for production and periodic injection of the appropriate bacteria to the treatment tank, and a biological filter. A dramatic reduction of oil and grease in the bakery waste from approximately 1.5 g/L to less than 0.03 g/L, which is three times less than accepted regulatory limits, resulted. Reliable functioning of the bioremediation system has been observed during an extended period of time (20 months). JF - Water Environment Research AU - Keenan, D AU - Sabelnikov, A AD - Perlucid Corporation, 125 Lake Avenue, South Suite 25, Nesconset, NY 11767, USA, sabshel@bnl.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 141 EP - 146 VL - 72 IS - 2 SN - 1061-4303, 1061-4303 KW - bakeries KW - grease KW - Aqualine Abstracts; Water Resources Abstracts; Pollution Abstracts KW - Standards (Water quality) KW - Bacteria KW - Bioremediation KW - Food industries waste KW - Grease KW - Wastewater treatment KW - Biological treatment KW - Oil KW - Food processing industry wastes KW - Water Quality Standards KW - Oil (General) KW - Food-processing Wastes KW - Wastewater Treatment KW - Biological Treatment KW - P 3000:SEWAGE & WASTEWATER TREATMENT KW - AQ 00006:Sewage KW - SW 3040:Wastewater treatment processes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17545460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Environment+Research&rft.atitle=Biological+Augmentation+Eliminates+Grease+and+Oil+in+Bakery+Wastewater&rft.au=Keenan%2C+D%3BSabelnikov%2C+A&rft.aulast=Keenan&rft.aufirst=D&rft.date=2000-04-01&rft.volume=72&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Water+Environment+Research&rft.issn=10614303&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Grease; Oil; Wastewater Treatment; Food-processing Wastes; Water Quality Standards; Biological Treatment; Oil (General); Wastewater treatment; Food industries waste; Standards (Water quality); Biological treatment; Food processing industry wastes; Bacteria; Bioremediation ER - TY - JOUR T1 - Regulation of competence for genetic transformation in Streptococcus pneumoniae: expression of dpnA, a late competence gene encoding a DNA methyltransferase of the DpnII restriction system AN - 17510599; 4695144 AB - The chromosomal DpnII gene cassette of Streptococcus pneumoniae encodes two methyltransferases and an endonuclease. One methyltransferase acts on double-stranded and the other on single-stranded DNA. Two mRNAs are transcribed from the cassette. One, a SigA promoter transcript, includes all three genes; the other includes a truncated form of the second methyltransferase gene (dpnA) and the endonuclease gene. The truncated dpnA, which is translated from the second start codon in the full gene, was shown to produce active enzyme. A promoter reporter plasmid for S. pneumoniae was devised to characterize the promoter for the second mRNA. This transcript was found to depend on a promoter that responded to the induction of competence for genetic transformation. The promoter contains the combox sequence recognized by a SigH-containing RNA polymerase. As part of the competence regulon, the dpnA gene makes a product able to methylate incoming plasmid strands to protect them from the endonuclease and allow plasmid establishment. Its function differs from most genes in the regulon, which are involved in DNA uptake. Comparison of R6 and Rx strains of S. pneumoniae showed the temperature dependence of transformation in R6 to result from temperature sensitivity of the uptake apparatus and not the development of competence. JF - Molecular Microbiology AU - Lacks, SA AU - Ayalew, S AU - de la Campa, AG AU - Greenberg, B AD - Department of Biology, Brookhaven National Laboratory, Upton, NY 11973, USA, lacks@bnl.gov Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 1089 EP - 1098 VL - 35 IS - 5 SN - 0950-382X, 0950-382X KW - DNA methyltransferase DpnII KW - SigA gene KW - dpnA gene KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Transformation KW - Streptococcus pneumoniae KW - Gene regulation KW - G 07320:Bacterial genetics KW - N 14674:Transformation KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17510599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Regulation+of+competence+for+genetic+transformation+in+Streptococcus+pneumoniae%3A+expression+of+dpnA%2C+a+late+competence+gene+encoding+a+DNA+methyltransferase+of+the+DpnII+restriction+system&rft.au=Lacks%2C+SA%3BAyalew%2C+S%3Bde+la+Campa%2C+AG%3BGreenberg%2C+B&rft.aulast=Lacks&rft.aufirst=SA&rft.date=2000-03-01&rft.volume=35&rft.issue=5&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1046%2Fj.1365-2958.2000.01777.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Transformation; Gene regulation DO - http://dx.doi.org/10.1046/j.1365-2958.2000.01777.x ER - TY - JOUR T1 - Cocaine abusers show a blunted response to alcohol intoxication in limbic brain regions. AN - 71002328; 10737368 AB - UNLABELLEDCocaine and alcohol are frequently used simultaneously and this combination is associated with enhanced toxicity. We recently showed that active cocaine abusers have a markedly enhanced sensitivity to benzodiazepines. Because both benzodiazepines and alcohol facilitate GABAergic neurotransmission we questioned whether cocaine abusers would also have an enhanced sensitivity to alcohol that could contribute to the toxicity. In this study we compared the effects of alcohol (0.75 g/kg) on regional brain glucose metabolism between cocaine abusers (n = 9) and controls (n = 10) using PET and FDG. Alcohol significantly decreased whole brain metabolism and this effect was greater in controls (26+/-6%) than in abusers (17+/-10%) even though they had equivalent levels of alcohol in plasma. Analysis of the regional measures showed that cocaine abusers had a blunted response to alcohol in limbic regions, cingulate gyrus, medial frontal and orbitofrontal cortices.CONCLUSIONSThe blunted response to alcohol in cocaine abusers contrasts with their enhanced sensitivity to benzodiazepines suggesting that targets other than GABA-benzodiazepine receptors are involved in the blunted sensitivity to alcohol and that the toxicity from combined cocaine-alcohol use is not due to an enhanced sensitivity to alcohol in cocaine abusers. The blunted response to alcohol in limbic regions and in cortical regions connected to limbic areas could result from a decreased sensitivity of reward circuits in cocaine abusers. JF - Life sciences AU - Volkow, N D AU - Wang, G J AU - Fowler, J S AU - Franceschi, D AU - Thanos, P K AU - Wong, C AU - Gatley, S J AU - Ding, Y S AU - Molina, P AU - Schlyer, D AU - Alexoff, D AU - Hitzemann, R AU - Pappas, N AD - Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2000/02/11/ PY - 2000 DA - 2000 Feb 11 SP - PL161 EP - PL167 VL - 66 IS - 12 SN - 0024-3205, 0024-3205 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Humans KW - Fluorodeoxyglucose F18 -- metabolism KW - Adult KW - Tomography, Emission-Computed KW - Limbic System -- physiopathology KW - Alcoholic Intoxication -- diagnostic imaging KW - Limbic System -- diagnostic imaging KW - Limbic System -- metabolism KW - Alcoholic Intoxication -- physiopathology KW - Glucose -- metabolism KW - Cocaine-Related Disorders -- physiopathology KW - Cocaine-Related Disorders -- metabolism KW - Alcoholic Intoxication -- metabolism KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71002328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Cocaine+abusers+show+a+blunted+response+to+alcohol+intoxication+in+limbic+brain+regions.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BFowler%2C+J+S%3BFranceschi%2C+D%3BThanos%2C+P+K%3BWong%2C+C%3BGatley%2C+S+J%3BDing%2C+Y+S%3BMolina%2C+P%3BSchlyer%2C+D%3BAlexoff%2C+D%3BHitzemann%2C+R%3BPappas%2C+N&rft.aulast=Volkow&rft.aufirst=N&rft.date=2000-02-11&rft.volume=66&rft.issue=12&rft.spage=PL161&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-31 N1 - Date created - 2000-03-31 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Poor design of local exhaust hood leads to radioactive release in the work area AN - 17466508; 4669018 AB - At a U.S. Department of Energy (DOE) waste handling facility, transuranic waste contained in standard 208-L (55-gallon) drums was being prepared to meet the DOE's Waste Isolation Pilot Project Waste Acceptance Criteria. During a particular waste handling operation, it was necessary for the workers to open several 208-L drums with TRU waste and prepare the waste to meet the WIPP Waste Acceptance Criteria. This operation was performed while the waste drums where positioned adjacent to a drum ventilator, which was designed to capture emissions generated from the drums during waste handling activities. During this activity, the continuous air monitor alarmed and reached an instantaneous air concentration of 0.1 Bq m super(-3), or a factor of 300 times higher than the derived air concentration for inhalation class W super(239)Pu. The DOE conducted an investigation to determine why the drum ventilator did not control the transuranic emissions and to evaluate possible improvements to the drum ventilator and exposure controls. By adding upper and lower flanges to the drum ventilator, the capture velocity was increased by 88% without increasing the fan's speed. Adding flanges is a simple and inexpensive modification that enhances the performance of the drum ventilator. In addition to a poor design, the drum ventilator's capture velocity was compromised by competing air velocities that were generated by waste handling activities. JF - Health Physics AU - Reif, R H AU - Houck, R S AD - U.S. Department of Energy, Brookhaven Group, 53 Bell Avenue, Upton, NY 11973, USA, rreif@bnl.gov Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 222 EP - 225 VL - 78 IS - 2 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Ventilation KW - Materials handling KW - Emission control equipment KW - Occupational exposure KW - Radioactive wastes KW - Storage KW - Hazardous wastes KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17466508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Poor+design+of+local+exhaust+hood+leads+to+radioactive+release+in+the+work+area&rft.au=Reif%2C+R+H%3BHouck%2C+R+S&rft.aulast=Reif&rft.aufirst=R&rft.date=2000-02-01&rft.volume=78&rft.issue=2&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hazardous wastes; Radioactive wastes; Emission control equipment; Materials handling; Ventilation; Occupational exposure; Storage ER - TY - JOUR T1 - Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. AN - 70808797; 10618378 AB - Clustered DNA damages-two or more closely spaced damages (strand breaks, abasic sites, or oxidized bases) on opposing strands-are suspects as critical lesions producing lethal and mutagenic effects of ionizing radiation. However, as a result of the lack of methods for measuring damage clusters induced by ionizing radiation in genomic DNA, neither the frequencies of their production by physiological doses of radiation, nor their repairability, nor their biological effects are known. On the basis of methods that we developed for quantitating damages in large DNAs, we have devised and validated a way of measuring ionizing radiation-induced clustered lesions in genomic DNA, including DNA from human cells. DNA is treated with an endonuclease that induces a single-strand cleavage at an oxidized base or abasic site. If there are two closely spaced damages on opposing strands, such cleavage will reduce the size of the DNA on a nondenaturing gel. We show that ionizing radiation does induce clustered DNA damages containing abasic sites, oxidized purines, or oxidized pyrimidines. Further, the frequency of each of these cluster classes is comparable to that of frank double-strand breaks; among all complex damages induced by ionizing radiation, double-strand breaks are only about 20%, with other clustered damage constituting some 80%. We also show that even low doses (0.1-1 Gy) of high linear energy transfer ionizing radiation induce clustered damages in human cells. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Sutherland, B M AU - Bennett, P V AU - Sidorkina, O AU - Laval, J AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. bms@bnl.gov Y1 - 2000/01/04/ PY - 2000 DA - 2000 Jan 04 SP - 103 EP - 108 VL - 97 IS - 1 SN - 0027-8424, 0027-8424 KW - Escherichia coli Proteins KW - 0 KW - Pyrimidines KW - DNA KW - 9007-49-2 KW - Endodeoxyribonucleases KW - EC 3.1.- KW - Deoxyribonuclease IV (Phage T4-Induced) KW - EC 3.1.21.2 KW - Deoxyribonuclease (Pyrimidine Dimer) KW - EC 3.1.25.1 KW - NTH protein, E coli KW - N-Glycosyl Hydrolases KW - EC 3.2.2.- KW - DNA-Formamidopyrimidine Glycosylase KW - EC 3.2.2.23 KW - Carbon-Oxygen Lyases KW - EC 4.2.- KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - EC 4.2.99.18 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Pyrimidines -- chemistry KW - Gamma Rays KW - Humans KW - Bacteriophage T7 KW - Cell Survival KW - X-Rays KW - Electrophoresis, Agar Gel KW - Monocytes -- radiation effects KW - DNA -- chemistry KW - DNA -- radiation effects KW - DNA Damage -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70808797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Clustered+DNA+damages+induced+in+isolated+DNA+and+in+human+cells+by+low+doses+of+ionizing+radiation.&rft.au=Sutherland%2C+B+M%3BBennett%2C+P+V%3BSidorkina%2C+O%3BLaval%2C+J&rft.aulast=Sutherland&rft.aufirst=B&rft.date=2000-01-04&rft.volume=97&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-10 N1 - Date created - 2000-02-10 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Nat New Biol. 1973 Feb 7;241(110):170-2 [4573269] Biochemistry. 1992 Jan 14;31(1):106-10 [1731864] Radiat Res. 1981 May;86(2):185-95 [7015409] Radiat Environ Biophys. 1983;21(4):305-7 [6867270] Radiat Res Suppl. 1985;8:S103-11 [3867077] Somat Cell Mol Genet. 1986 Mar;12(2):185-95 [3008351] Mutat Res. 1986 Sep;166(2):187-98 [2429177] Proc Natl Acad Sci U S A. 1986 Oct;83(20):7731-5 [2429316] Anal Biochem. 1986 Oct;158(1):119-29 [3799960] Anal Biochem. 1987 May 1;162(2):511-20 [3605613] Biochemistry. 1993 Nov 16;32(45):12105-11 [8218289] Int J Radiat Biol. 1994 Jan;65(1):7-17 [7905912] Radiat Res. 1994 May;138(2):186-92 [8183988] Nucleic Acids Res. 1994 Jun 11;22(11):2010-5 [7518077] J Biol Chem. 1994 Jul 22;269(29):18814-20 [8034633] Int J Radiat Biol. 1994 Nov;66(5):427-32 [7983426] Int J Radiat Biol. 1994 Nov;66(5):523-9 [7983440] Radiat Res. 1995 Jun;142(3):362-8 [7761586] J Mol Biol. 1995 Jun 23;249(5):914-22 [7791217] J Biol Chem. 1996 Apr 19;271(16):9573-8 [8621631] Anal Biochem. 1996 Jul 15;239(1):53-60 [8660625] Radiat Res. 1997 Feb;147(2):215-24 [9008214] Proc Natl Acad Sci U S A. 1972 Oct;69(10):2927-31 [4562747] J Biol Chem. 1997 Jun 20;272(25):15650-5 [9188454] Mol Cell Biol. 1997 Sep;17(9):5437-52 [9271420] Radiat Res. 1997 Sep;148(3):216-26 [9291352] Radiat Res. 1997 Nov;148(5 Suppl):S17-23 [9355852] Nucleic Acids Res. 1998 Feb 15;26(4):932-41 [9461450] Science. 1998 May 15;280(5366):1066-9 [9582118] Biochemistry. 1998 May 26;37(21):7757-63 [9601036] Radiat Res. 1998 Jun;149(6):560-9 [9611094] Int J Radiat Biol. 1998 Jul;74(1):99-109 [9687979] J Biol Chem. 1998 Oct 30;273(44):28837-44 [9786884] Radiat Res. 1998 Nov;150(5 Suppl):S42-51 [9806608] Radiat Res. 1998 Nov;150(5 Suppl):S60-79 [9806610] Radiat Res. 1998 Dec;150(6):612-8 [9840180] Radiat Res. 1998 Dec;150(6):695-705 [9840190] Int J Radiat Biol. 1999 Jan;75(1):51-8 [9972791] Radiat Res. 1999 Mar;151(3):334-42 [10073672] Carcinogenesis. 1999 May;20(5):905-9 [10334210] Anal Biochem. 1987 Jun;163(2):446-57 [3661993] Radiat Environ Biophys. 1988;27(2):123-32 [2839862] Biochemistry. 1989 May 16;28(10):4444-9 [2669955] Electrophoresis. 1989 May-Jun;10(5-6):318-26 [2767040] J Biol Chem. 1990 Mar 5;265(7):3916-22 [1689309] Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4690-4 [2052552] Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Feb;33(2):105-20 [305424] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - In vitro neurotoxic effects of 1 GeV/n iron particles assessed in retinal explants. AN - 72487357; 11542855 AB - The heavy ion component of the cosmic radiation remains problematic to the assessment of risk in manned space flight. The biological effectiveness of HZE particles has yet to be established, particularly with regard to nervous tissue. Using heavy ions accelerated at the AGS of Brookhaven National Laboratory, we study the neurotoxic effects of iron particles. We exposed retinal explants, taken from chick embryos, to determine the dose response relationships for neurite outgrowth. Morphometric techniques were used to evaluate the in vitro effects of 1 GeV/a iron particles (LET 148 keV/micrometer). Iron particles produced a dose-dependent reduction of neurite outgrowth with a maximal effect achieved with a dose of 100 cGy. Doses as low as 10-50 cGy were able to induce reductions of the neurite outgrowth as compared to the control group. Neurite generation is a more sensitive parameter than neurite elongation, suggesting different mechanism of radiation damage in our model. These results showed that low doses/fluences of iron particles could impair the retinal ganglion cells' capacity to generate neurites indicating the highly neurotoxic capability of this heavy charged particle. JF - Advances in space research : the official journal of the Committee on Space Research (COSPAR) AU - Vazquez, M E AU - Kirk, E AD - Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2000 PY - 2000 DA - 2000 SP - 2041 EP - 2049 VL - 25 IS - 10 SN - 0273-1177, 0273-1177 KW - Iron KW - E1UOL152H7 KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Radiation Dosage KW - Animals KW - Culture Techniques KW - Synchrotrons KW - Chick Embryo KW - Dose-Response Relationship, Radiation KW - Retina -- cytology KW - Retinal Ganglion Cells -- radiation effects KW - Retinal Ganglion Cells -- physiology KW - Heavy Ions KW - Neurites -- radiation effects KW - Neurites -- physiology KW - Retina -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72487357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+space+research+%3A+the+official+journal+of+the+Committee+on+Space+Research+%28COSPAR%29&rft.atitle=In+vitro+neurotoxic+effects+of+1+GeV%2Fn+iron+particles+assessed+in+retinal+explants.&rft.au=Vazquez%2C+M+E%3BKirk%2C+E&rft.aulast=Vazquez&rft.aufirst=M&rft.date=2000-01-01&rft.volume=25&rft.issue=10&rft.spage=2041&rft.isbn=&rft.btitle=&rft.title=Advances+in+space+research+%3A+the+official+journal+of+the+Committee+on+Space+Research+%28COSPAR%29&rft.issn=02731177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-04 N1 - Date created - 2000-05-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Crystal growth, structure characterization, and schemes for economic transport; an integrated approach to the study of natural gas hydrates AN - 52173929; 2001-075351 JF - Annals of the New York Academy of Sciences AU - Mahajan, D AU - Koetzle, T F AU - Klooster, W T AU - Brammer, L AU - McMullan, R K AU - Goland, A N A2 - Holder, Gerald D. A2 - Bishnoi, P. R. Y1 - 2000 PY - 2000 DA - 2000 SP - 940 EP - 949 PB - New York Academy of Sciences, New York, NY VL - 912 SN - 0077-8923, 0077-8923 KW - experimental studies KW - methane KW - gas hydrates KW - natural gas KW - characterization KW - aliphatic hydrocarbons KW - petroleum KW - crystal structure KW - crystal growth KW - transportation KW - alkanes KW - cost KW - sample preparation KW - organic compounds KW - X-ray data KW - neutron diffraction data KW - hydrocarbons KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52173929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Crystal+growth%2C+structure+characterization%2C+and+schemes+for+economic+transport%3B+an+integrated+approach+to+the+study+of+natural+gas+hydrates&rft.au=Mahajan%2C+D%3BKoetzle%2C+T+F%3BKlooster%2C+W+T%3BBrammer%2C+L%3BMcMullan%2C+R+K%3BGoland%2C+A+N&rft.aulast=Mahajan&rft.aufirst=D&rft.date=2000-01-01&rft.volume=912&rft.issue=&rft.spage=940&rft.isbn=1573312428&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ L2 - http://www.nyas.org/annals/index.asp LA - English DB - GeoRef N1 - Conference title - Third international conference on Gas hydrates N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2001-01-01 N1 - Number of references - 19 N1 - PubXState - NY N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - ANYAA9 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; characterization; cost; crystal growth; crystal structure; experimental studies; gas hydrates; hydrocarbons; methane; natural gas; neutron diffraction data; organic compounds; petroleum; sample preparation; transportation; X-ray data ER - TY - BOOK T1 - Tritium source characterization at the high flux beam reactor, Brookhaven National Laboratory AN - 52171264; 2002-001739 JF - Vadose zone; science and technology solutions; volume 1 AU - Looney, Brian B AU - Paquette, Douglas E A2 - Looney, Brian B. A2 - Falta, Ronald W. Y1 - 2000 PY - 2000 DA - 2000 PB - Battelle Press, Columbus, OH SN - 1574770853 KW - United States KW - aquifer vulnerability KW - water quality KW - isotopes KW - Brookhaven National Laboratory KW - characterization KW - unsaturated zone KW - observation wells KW - tritium KW - preferential flow KW - environmental analysis KW - ground water KW - Suffolk County New York KW - radioactive isotopes KW - transport KW - mobility KW - concentration KW - migration of elements KW - aquifers KW - case studies KW - recharge KW - New York KW - hydrogen KW - theoretical models KW - shallow aquifers KW - nuclear facilities KW - water resources KW - point sources KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52171264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Looney%2C+Brian+B%3BPaquette%2C+Douglas+E&rft.aulast=Looney&rft.aufirst=Brian&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=1574770853&rft.btitle=Tritium+source+characterization+at+the+high+flux+beam+reactor%2C+Brookhaven+National+Laboratory&rft.title=Tritium+source+characterization+at+the+high+flux+beam+reactor%2C+Brookhaven+National+Laboratory&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - OH N1 - Document feature - illus. N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Silica production from low-salinity geothermal brines AN - 51100035; 2007-060398 AB - Earlier studies have shown that the extraction of valuable products from geothermal resources could offset the overall cost of power generation. Silica extraction is of special interest because it may reduce or prevent silica scaling, which is detrimental to plant operations. At the same time, silica extraction can produce a valuable commodity for other industries. Based on these studies, a pilot plant has been designed and constructed for the extraction of silica from low-salinity brines at Dixie Valley, Nevada. Some results dealing with the properties of silica recovered from the preliminary field tests and the commercial usage of such products will be discussed. JF - Transactions - Geothermal Resources Council AU - Lin, Mow S AU - Bohenek, Michael AU - Premuzic, Eugene T AU - Johnson, Stuart D Y1 - 2000 PY - 2000 DA - 2000 SP - 671 EP - 674 PB - GRC - Geothermal Resources Council, Davis, CA VL - 24 SN - 0193-5933, 0193-5933 KW - United States KW - Churchill County Nevada KW - experimental studies KW - recycling KW - salinity KW - cost KW - Dixie Valley KW - partitioning KW - laboratory studies KW - sample preparation KW - geothermal systems KW - silica KW - precipitation KW - brines KW - pilot plants KW - silica scaling KW - industrial minerals KW - Nevada KW - 28A:Economic geology, geology of nonmetal deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51100035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+-+Geothermal+Resources+Council&rft.atitle=Silica+production+from+low-salinity+geothermal+brines&rft.au=Lin%2C+Mow+S%3BBohenek%2C+Michael%3BPremuzic%2C+Eugene+T%3BJohnson%2C+Stuart+D&rft.aulast=Lin&rft.aufirst=Mow&rft.date=2000-01-01&rft.volume=24&rft.issue=&rft.spage=671&rft.isbn=0934412847&rft.btitle=&rft.title=Transactions+-+Geothermal+Resources+Council&rft.issn=01935933&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geothermal Resources Council 2000 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 4 N1 - PubXState - CA N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - brines; Churchill County Nevada; cost; Dixie Valley; experimental studies; geothermal systems; industrial minerals; laboratory studies; Nevada; partitioning; pilot plants; precipitation; recycling; salinity; sample preparation; silica; silica scaling; United States ER - TY - JOUR T1 - The U.S. National Research Council's views of the radiation hazards in space. AN - 69402461; 10631330 AB - The author was the Chairman of a Task Group on the Biological Effects of Space Radiation formed as a result of discussions between NASA and the U.S. National Research Council's Committee on Space Biology and Medicine - a committee under the U.S. National Research Council's Space Studies Board. The Task Group was asked to review current knowledge on the effects of long-term exposure to radiation in space and to consider NASA radiation shielding requirements for orbital and interplanetary spacecraft. The group was charged with assessing the adequacy of NASA planning for the protection of humans from radiation in space and with making recommendations regarding needed research and/or new shielding requirements. This manuscript is a summary of the findings and recommendations of the Task Group. Beyond the protection of the Earth's atmosphere and its magnetosphere, the exposure to ionizing radiations far exceeds that on Earth. Of all the risks astronauts may face, this one is probably the most straightforward to control - by providing adequate shielding. However, because shielding adds weight, cost and complexity to space vehicles, it is important for designers to have a good quantitative understanding of the true risk and its degree of uncertainty so as not to under- or overshield spacecrafts. The extrapolations from our knowledge of ionizing radiation effects of low linear energy transfer (LET) to the risks from high-atomic-number high-energy energetic (HZE) cosmic rays are very uncertain because the necessary experiments on the effects of such particles have not been carried out and the extrapolation from low-LET to very high-LET has great uncertainties. These uncertainties were enumerated by the Task Group, and the types of experiments needed to minimize the uncertainties were described. The report found that, because of the small amounts of available time for biological research at HZE accelerators, it would take more than a decade of effort to obtain the answers to a narrow set of key questions that would facilitate reduction in risks and identification of the types of shielding needed. JF - Mutation research AU - Setlow, R B AD - Biology Department, Brookhaven National Laboratory, Box 5000, Upton, NY 11973-5000, USA. setlow@bnl.gov Y1 - 1999/12/06/ PY - 1999 DA - 1999 Dec 06 SP - 169 EP - 175 VL - 430 IS - 2 SN - 0027-5107, 0027-5107 KW - Index Medicus KW - Space life sciences KW - Non-programmatic KW - United States KW - Animals KW - Neoplasms, Radiation-Induced -- etiology KW - Radiation Injuries -- prevention & control KW - Mice KW - Risk Assessment KW - Mutagenesis KW - Radiation Protection -- standards KW - Rats KW - Relative Biological Effectiveness KW - Radiation Protection -- methods KW - Astronauts KW - Sebaceous Gland Neoplasms -- etiology KW - Harderian Gland -- radiation effects KW - National Academy of Sciences (U.S.) KW - Radiation Injuries, Experimental -- etiology KW - Linear Energy Transfer KW - Radiation KW - Space Flight KW - Extraterrestrial Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69402461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+U.S.+National+Research+Council%27s+views+of+the+radiation+hazards+in+space.&rft.au=Setlow%2C+R+B&rft.aulast=Setlow&rft.aufirst=R&rft.date=1999-12-06&rft.volume=430&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-28 N1 - Date created - 2000-01-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Environmental factors in nonmelanoma and melanoma skin cancer. AN - 69449682; 10709358 AB - We discuss the role of sunlight, mostly ultraviolet light (UV), in the induction of nonmelanoma and melanoma skin cancer. Whilst the former seems to be correlated with accumulated exposure, the causation of melanoma is more complex, and may also involve the pattern of, and age at, exposure. The efficacy of sunscreens is debatable; while they protect against UVB wavelengths (290-320 nm), and so extend the time that may be spent in the sun before becoming sunburnt, their use may subject wearers to excessive exposure to UVA (320-400 nm) and visible light. Both epidemiological surveys and experiments with animal models suggest that UVA, and perhaps the visible, may induce melanomas. Although Japanese have a much lower incidence of skin cancer than Caucasians, the dramatic rise in skin cancer in Japanese-Americans in Hawaii exposed to high-intensity irradiation raises concerns. If the Japanese people adopt sun-seeking behavior, or should the levels of UV irradiation rise significantly through depletion of the ozone layer, then this could become an important health problem in future. JF - Journal of epidemiology AU - Woodhead, A D AU - Setlow, R B AU - Tanaka, M AD - Brookhaven National Laboratory Upton, New York 11973, USA. Y1 - 1999/12// PY - 1999 DA - December 1999 SP - S102 EP - S114 VL - 9 IS - 6 Suppl SN - 0917-5040, 0917-5040 KW - Index Medicus KW - Japan -- epidemiology KW - Environmental Monitoring KW - Animals KW - Disease Susceptibility KW - Humans KW - Fishes KW - Incidence KW - Disease Models, Animal KW - Epidemiological Monitoring KW - United States -- epidemiology KW - Risk Assessment KW - Carcinoma, Squamous Cell -- etiology KW - Carcinoma, Squamous Cell -- epidemiology KW - Carcinoma, Basal Cell -- etiology KW - Skin Neoplasms -- etiology KW - Melanoma -- etiology KW - Environmental Exposure -- analysis KW - Ultraviolet Rays -- adverse effects KW - Skin Neoplasms -- epidemiology KW - Carcinoma, Basal Cell -- epidemiology KW - Environmental Exposure -- adverse effects KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69449682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+epidemiology&rft.atitle=Environmental+factors+in+nonmelanoma+and+melanoma+skin+cancer.&rft.au=Woodhead%2C+A+D%3BSetlow%2C+R+B%3BTanaka%2C+M&rft.aulast=Woodhead&rft.aufirst=A&rft.date=1999-12-01&rft.volume=9&rft.issue=6+Suppl&rft.spage=S102&rft.isbn=&rft.btitle=&rft.title=Journal+of+epidemiology&rft.issn=09175040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-23 N1 - Date created - 2000-03-23 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. AN - 69429649; 10667609 AB - We summarize our studies with positron emission tomography investigating the role of dopamine (DA) in the reinforcing effects of cocaine and methylphenidate in humans and its involvement in cocaine addiction. These studies have shown that the rate at which cocaine and methylphenidate enter the brain and block the dopamine transporters (DAT) is the variable associated with the 'high', rather than the presence per se of the drug in the brain. Our studies also show that, while the level of DAT blockade is important in predicting the intensity of the 'high' induced by these drugs (DAT blockade > 50% is required for these drugs to induce a 'high'), the rate at which DAT are blocked determines whether the 'high' is perceived or not. Thus, oral methylphenidate, which leads to slow DAT blockade, does not induce a 'high', even at doses which block DAT more than 60%. In cocaine abusers, we have shown significant reductions in DA D2 receptors that are associated with decreased metabolism in cingulate gyrus and in orbitofrontal cortex. We suggest that this is one of the mechanisms by which DA disruption leads to compulsive drug administration in cocaine addiction. Cocaine abusers also show significant decreases in DA release, which coupled with the reduction in D2 receptors may result in decreased activation of reward circuits by physiological reinforcers and may perpetuate cocaine use as a means to compensate for this deficit. Thus, strategies to enhance DA brain function in ways that mimic physiological DA activity may be of help in overcoming cocaine addiction. JF - Journal of psychopharmacology (Oxford, England) AU - Volkow, N D AU - Fowler, J S AU - Wang, G J AD - Department of Medicine, Brookhaven National Laboratory, Upton, New York, NY 11973, USA. volkow@bnl.gov Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 337 EP - 345 VL - 13 IS - 4 SN - 0269-8811, 0269-8811 KW - Carrier Proteins KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Receptors, Dopamine KW - SLC6A3 protein, human KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Humans KW - Reinforcement (Psychology) KW - Tomography, Emission-Computed KW - Brain -- physiopathology KW - Receptors, Dopamine -- physiology KW - Carrier Proteins -- metabolism KW - Dopamine -- physiology KW - Cocaine-Related Disorders -- physiopathology KW - Receptors, Dopamine -- analysis KW - Carrier Proteins -- analysis KW - Cocaine -- pharmacology KW - Brain -- physiology KW - Brain -- diagnostic imaging KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69429649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychopharmacology+%28Oxford%2C+England%29&rft.atitle=Imaging+studies+on+the+role+of+dopamine+in+cocaine+reinforcement+and+addiction+in+humans.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWang%2C+G+J&rft.aulast=Volkow&rft.aufirst=N&rft.date=1999-12-01&rft.volume=13&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychopharmacology+%28Oxford%2C+England%29&rft.issn=02698811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-18 N1 - Date created - 2000-02-18 N1 - Date revised - 2017-02-18 N1 - Last updated - 2017-02-23 ER - TY - JOUR T1 - Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. AN - 69292425; 10567268 AB - Binding of virus particles to specific host cell surface receptors is known to be an obligatory step in infection even though the molecular basis for these interactions is not well characterized. The crystal structure of the adenovirus fiber knob domain in complex with domain I of its human cellular receptor, coxsackie and adenovirus receptor (CAR), is presented here. Surface-exposed loops on knob contact one face of CAR, forming a high-affinity complex. Topology mismatches between interacting surfaces create interfacial solvent-filled cavities and channels that may be targets for antiviral drug therapy. The structure identifies key determinants of binding specificity, which may suggest ways to modify the tropism of adenovirus-based gene therapy vectors. JF - Science (New York, N.Y.) AU - Bewley, M C AU - Springer, K AU - Zhang, Y B AU - Freimuth, P AU - Flanagan, J M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1999/11/19/ PY - 1999 DA - 1999 Nov 19 SP - 1579 EP - 1583 VL - 286 IS - 5444 SN - 0036-8075, 0036-8075 KW - CLMP protein, human KW - 0 KW - Capsid Proteins KW - Coxsackie and Adenovirus Receptor-Like Membrane Protein KW - Receptors, Virus KW - Recombinant Proteins KW - hexon capsid protein, Adenovirus KW - Index Medicus KW - Crystallization KW - Protein Structure, Secondary KW - Thermodynamics KW - Models, Molecular KW - Protein Binding KW - Binding Sites KW - Mutagenesis KW - Recombinant Proteins -- metabolism KW - Crystallography, X-Ray KW - Recombinant Proteins -- chemistry KW - Hydrogen Bonding KW - Amino Acid Substitution KW - Protein Conformation KW - Adenoviruses, Human -- metabolism KW - Adenoviruses, Human -- chemistry KW - Capsid -- metabolism KW - Receptors, Virus -- metabolism KW - Capsid -- chemistry KW - Receptors, Virus -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69292425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Structural+analysis+of+the+mechanism+of+adenovirus+binding+to+its+human+cellular+receptor%2C+CAR.&rft.au=Bewley%2C+M+C%3BSpringer%2C+K%3BZhang%2C+Y+B%3BFreimuth%2C+P%3BFlanagan%2C+J+M&rft.aulast=Bewley&rft.aufirst=M&rft.date=1999-11-19&rft.volume=286&rft.issue=5444&rft.spage=1579&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-12-09 N1 - Date created - 1999-12-09 N1 - Date revised - 2017-02-17 N1 - Genetic sequence - 1NOB; PDB; 1KAC N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Electronic and magnetic properties of iron and iron oxide at high pressure AN - 52163872; 2002-001427 JF - Eos, Transactions, American Geophysical Union AU - Badro, James AU - Struzhkin, Viktor V AU - Hemley, Russell J AU - Mao, Ho-kwang AU - Kao, Chi-Chang AU - Anonymous Y1 - 1999/11// PY - 1999 DA - November 1999 SP - 1116 PB - American Geophysical Union, Washington, DC VL - 80 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - electronic properties KW - pressure KW - iron oxides KW - iron minerals KW - bonding KW - high pressure KW - iron KW - order-disorder KW - magnetic properties KW - metals KW - oxides KW - spectra KW - anvil cells KW - Mossbauer spectra KW - geophysics KW - electrons KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52163872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Electronic+and+magnetic+properties+of+iron+and+iron+oxide+at+high+pressure&rft.au=Badro%2C+James%3BStruzhkin%2C+Viktor+V%3BHemley%2C+Russell+J%3BMao%2C+Ho-kwang%3BKao%2C+Chi-Chang%3BAnonymous&rft.aulast=Badro&rft.aufirst=James&rft.date=1999-11-01&rft.volume=80&rft.issue=46%2C+Suppl.&rft.spage=1116&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1999 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 1 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - anvil cells; bonding; electronic properties; electrons; geophysics; high pressure; iron; iron minerals; iron oxides; magnetic properties; metals; Mossbauer spectra; order-disorder; oxides; pressure; spectra ER - TY - JOUR T1 - Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374). AN - 69277843; 10556675 AB - The electrically-evoked release of [3H]acetylcholine from hippocampal brain slices is inhibited by cannabinoid receptor agonists. The effect of palmitylsulphonyl fluoride (AM 374), a recently developed inhibitor of fatty acid amide hydrolase, in influencing the potency of exogenously added anandamide in this preparation was examined. Anandamide alone had relatively little effect on [3H]acetylcholine release. By contrast, in the presence of AM 374 (0.1 microM), anandamide produced a significant inhibition of [3H]acetylcholine release at all concentrations tested (0.1-10 microM). In addition to experiments with AM 374 the effects of N-(4-hydroxyphenyl)arachidonamide (AM 404), a putative anandamide uptake inhibitor, was also examined. However, AM 404 at concentrations up to 10 microM, was not found to significantly enhance the effect of anandamide on electrically-evoked [3H]acetylcholine release. These results indicate that AM 374 potently inhibits endogenous amidase activity and thus facilitates access of exogenous anandamide to cannabinoid receptors in the hippocampal tissue. JF - European journal of pharmacology AU - Gifford, A N AU - Bruneus, M AU - Lin, S AU - Goutopoulos, A AU - Makriyannis, A AU - Volkow, N D AU - Gatley, S J AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. gifforda@bnl.gov Y1 - 1999/10/21/ PY - 1999 DA - 1999 Oct 21 SP - 9 EP - 14 VL - 383 IS - 1 SN - 0014-2999, 0014-2999 KW - AM 374 KW - 0 KW - Arachidonic Acids KW - Benzoxazines KW - Cannabinoids KW - Cyclohexanols KW - Endocannabinoids KW - Enzyme Inhibitors KW - Morpholines KW - N-(4-hydroxyphenyl)arachidonylamide KW - Naphthalenes KW - Palmitates KW - Polyunsaturated Alkamides KW - Receptors, Cannabinoid KW - Receptors, Drug KW - Win 55212-2 KW - 5H31GI9502 KW - 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol KW - 83003-12-7 KW - Amidohydrolases KW - EC 3.5.- KW - fatty-acid amide hydrolase KW - EC 3.5.1.- KW - Acetylcholine KW - N9YNS0M02X KW - anandamide KW - UR5G69TJKH KW - Index Medicus KW - Naphthalenes -- pharmacology KW - Animals KW - Cannabinoids -- metabolism KW - Morpholines -- pharmacology KW - Electric Stimulation KW - Rats KW - Acetylcholine -- metabolism KW - Rats, Sprague-Dawley KW - Receptors, Drug -- agonists KW - In Vitro Techniques KW - Cyclohexanols -- pharmacology KW - Drug Synergism KW - Male KW - Hippocampus -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Amidohydrolases -- antagonists & inhibitors KW - Palmitates -- pharmacology KW - Hippocampus -- drug effects KW - Arachidonic Acids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69277843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Potentiation+of+the+action+of+anandamide+on+hippocampal+slices+by+the+fatty+acid+amide+hydrolase+inhibitor%2C+palmitylsulphonyl+fluoride+%28AM+374%29.&rft.au=Gifford%2C+A+N%3BBruneus%2C+M%3BLin%2C+S%3BGoutopoulos%2C+A%3BMakriyannis%2C+A%3BVolkow%2C+N+D%3BGatley%2C+S+J&rft.aulast=Gifford&rft.aufirst=A&rft.date=1999-10-21&rft.volume=383&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-13 N1 - Date created - 2000-01-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - X-ray standing wave study of arsenite incorporation at the calcite surface AN - 52414989; 2000-003107 JF - Geochimica et Cosmochimica Acta AU - Cheng, Likwan AU - Fenter, Paul AU - Sturchio, Neil C AU - Zhong, Zhong AU - Bedzyk, Michael J A2 - Stipp, Susan L. S. A2 - Brady, Patrick V. A2 - Ragnarsdottir, K. Vala A2 - Charlet, Laurent Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 3153 EP - 3157 PB - Pergamon, Oxford VL - 63 IS - 19-20 SN - 0016-7037, 0016-7037 KW - experimental studies KW - X-ray diffraction data KW - crystal structure KW - crystal growth KW - calcite KW - laboratory studies KW - arsenites KW - X-ray data KW - chemical reactions KW - X-ray fluorescence spectra KW - spectra KW - geochemistry KW - carbonates KW - 01C:Mineralogy of non-silicates KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52414989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=X-ray+standing+wave+study+of+arsenite+incorporation+at+the+calcite+surface&rft.au=Cheng%2C+Likwan%3BFenter%2C+Paul%3BSturchio%2C+Neil+C%3BZhong%2C+Zhong%3BBedzyk%2C+Michael+J&rft.aulast=Cheng&rft.aufirst=Likwan&rft.date=1999-10-01&rft.volume=63&rft.issue=19-20&rft.spage=3153&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2FS0016-7037%2899%2900242-2 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 36 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - arsenites; calcite; carbonates; chemical reactions; crystal growth; crystal structure; experimental studies; geochemistry; laboratory studies; spectra; X-ray data; X-ray diffraction data; X-ray fluorescence spectra DO - http://dx.doi.org/10.1016/S0016-7037(99)00242-2 ER - TY - JOUR T1 - Coulometric total carbon dioxide analysis for marine studies; measurement and internal consistency of underway TCO (sub 2) concentrations AN - 52236902; 2001-030831 AB - A coulometrically-based SOMMA system for the determination of total dissolved carbon dioxide (TCO (sub 2) ) in a continuous mode was designed and tested at sea. The new continuous technique approached the same high accuracy and reliability associated with prior discrete TCO (sub 2) measurements. During three cruises encompassing more than 19 weeks and 6000 continuous TCO (sub 2) measurements none of the three different systems tested exhibited any hardware-related failures. We found that coulometer cell lifetimes can greatly exceed prior expectations with many of the titration cells in the continuous mode remaining accurate for up to 72 h at carbon ages exceeding 50 mg C. We suggest a practical definition based on the CRM analyses for changing coulometer cells in the continuous mode. Systematic deviations of the SOMMA pipette volume from a theoretical temperature dependence were identified both from field data comparisons and pipette calibrations. Hence pipettes should be kept at constant temperature or they must be gravimetrically calibrated over the expected temperature range. Comparison of the continuous TCO (sub 2) data together with simultaneously measured additional CO (sub 2) system parameters showed that the refitted "Mehrbach" dissociation constants for carbonic acid best-represent fCO (sub 2) when calculated from TCO (sub 2) and alkalinity over a wide range of sea-surface temperatures and salinities. Some remaining systematic differences of calculated-measured fCO (sub 2) of up to 9 mu atm likely reflect uncertainty in the temperature-dependence of the "Mehrbach" constants as well as possible uncertainty in the alkalinity-salinity relationship used to estimate alkalinity in the consistency checks. JF - Marine Chemistry AU - Johnson, Kenneth M AU - Koertzinger, Arne AU - Mintrop, Ludger AU - Duinker, Jan C AU - Wallace, Douglas W R Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 123 EP - 144 PB - Elsevier, Amsterdam VL - 67 IS - 1-2 SN - 0304-4203, 0304-4203 KW - concentration KW - chemical analysis KW - sea water KW - coulometry KW - SOMMA instrument KW - metabolism KW - techniques KW - hydrochemistry KW - Single Operator MultiMetabolic Analyzer KW - measurement KW - inorganic materials KW - geochemical cycle KW - carbon dioxide KW - dissolved materials KW - marine environment KW - carbon KW - carbon cycle KW - North Atlantic KW - geochemistry KW - instruments KW - Atlantic Ocean KW - 07:Oceanography KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52236902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Chemistry&rft.atitle=Coulometric+total+carbon+dioxide+analysis+for+marine+studies%3B+measurement+and+internal+consistency+of+underway+TCO+%28sub+2%29+concentrations&rft.au=Johnson%2C+Kenneth+M%3BKoertzinger%2C+Arne%3BMintrop%2C+Ludger%3BDuinker%2C+Jan+C%3BWallace%2C+Douglas+W+R&rft.aulast=Johnson&rft.aufirst=Kenneth&rft.date=1999-10-01&rft.volume=67&rft.issue=1-2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Marine+Chemistry&rft.issn=03044203&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/03044203 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2001-01-01 N1 - Number of references - 36 N1 - Document feature - illus. incl. 7 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - MRCHBD N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; carbon; carbon cycle; carbon dioxide; chemical analysis; concentration; coulometry; dissolved materials; geochemical cycle; geochemistry; hydrochemistry; inorganic materials; instruments; marine environment; measurement; metabolism; North Atlantic; sea water; Single Operator MultiMetabolic Analyzer; SOMMA instrument; techniques ER - TY - JOUR T1 - Gamma-vinyl gamma-aminobutyric acid attenuates the synergistic elevations of nucleus accumbens dopamine produced by a cocaine/heroin (speedball) challenge. AN - 70817425; 10513553 AB - In the present study, we examined the effect of an acute administration of the selective suicide inhibitor of gamma-aminobutyric acid (GABA)-transaminase, gamma-vinyl GABA on increases in nucleus accumbens dopamine produced by a cocaine/heroin challenge in freely moving animals. Cocaine (20 mg/kg, i.p.) produced an elevation in extracellular nucleus accumbens dopamine of approximately 380% above baseline, while heroin produced only a moderate increase of 70%. Coadministration of these two drugs, however, produced a synergistic elevation in nucleus accumbens dopamine of 1000%. This response was reduced by 50% in animals pretreated with gamma-vinyl GABA (300 mg/kg, i.p.) 2.5 h prior to challenge. This same dose of gamma-vinyl GABA inhibited cocaine-induced increases in nucleus accumbens dopamine by 25% and completely abolished heroin-induced increase. These findings indicate that gamma-vinyl GABA can interfere with the synergistic effects produced by the combination of an indirect dopamine releaser (heroin) and a dopamine reuptake blocker (cocaine). JF - European journal of pharmacology AU - Gerasimov, M R AU - Dewey, S L AD - Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1999/09/03/ PY - 1999 DA - 1999 Sep 03 SP - 1 EP - 4 VL - 380 IS - 1 SN - 0014-2999, 0014-2999 KW - Enzyme Inhibitors KW - 0 KW - Narcotics KW - Heroin KW - 70D95007SX KW - 4-Aminobutyrate Transaminase KW - EC 2.6.1.19 KW - Vigabatrin KW - GR120KRT6K KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Analysis of Variance KW - 4-Aminobutyrate Transaminase -- antagonists & inhibitors KW - Drug Synergism KW - Time Factors KW - Narcotics -- pharmacology KW - Male KW - Vigabatrin -- pharmacology KW - Heroin -- pharmacology KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Dopamine -- metabolism KW - Cocaine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70817425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Gamma-vinyl+gamma-aminobutyric+acid+attenuates+the+synergistic+elevations+of+nucleus+accumbens+dopamine+produced+by+a+cocaine%2Fheroin+%28speedball%29+challenge.&rft.au=Gerasimov%2C+M+R%3BDewey%2C+S+L&rft.aulast=Gerasimov&rft.aufirst=M&rft.date=1999-09-03&rft.volume=380&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-03 N1 - Date created - 1999-11-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. AN - 85247339; pmid-10484959 AB - OBJECTIVE: This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans. METHOD: [11C]Raclopride and positron emission tomography were used to measure D2 receptor levels in 23 healthy men (mean age = 34 years, SD = 7) who had no drug abuse histories in order to assess if there were differences between the subjects who liked and those who disliked the effects of intravenous methylphenidate (0.5 mg/kg). RESULTS: Subjects who liked the effects of methylphenidate had significantly lower D2 receptor levels (mean = 2.72 Bmax/Kd, SD = 0.3) than subjects who disliked its effects (mean = 3.16, SD = 0.3). Moreover, the higher the D2 levels found, the more intense were methylphenidate's unpleasant effects. CONCLUSIONS: These results provide preliminary evidence that D2 receptor levels predict response to psychostimulants in humans and that low D2 receptors may contribute to psychostimulant abuse by favoring pleasant response. JF - The American Journal of Psychiatry AU - Volkow, N D AU - Wang, G J AU - Fowler, J S AU - Logan, J AU - Gatley, S J AU - Gifford, A AU - Hitzemann, R AU - Ding, Y S AU - Pappas, N AD - Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N.Y., USA. PY - 1999 SP - 1440 EP - 1443 VL - 156 IS - 9 SN - 0002-953X, 0002-953X KW - Carbon Radioisotopes KW - Support, U.S. Gov't, P.H.S. KW - Human KW - Corpus Striatum KW - Methylphenidate KW - Central Nervous System Stimulants KW - Dopamine Antagonists KW - Salicylamides KW - Receptors, Dopamine D2 KW - Reward KW - Adult KW - Raclopride KW - Substance-Related Disorders KW - Support, U.S. Gov't, Non-P.H.S. KW - Tomography, Emission-Computed KW - Male KW - Reinforcement (Psychology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85247339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Prediction+of+reinforcing+responses+to+psychostimulants+in+humans+by+brain+dopamine+D2+receptor+levels.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BFowler%2C+J+S%3BLogan%2C+J%3BGatley%2C+S+J%3BGifford%2C+A%3BHitzemann%2C+R%3BDing%2C+Y+S%3BPappas%2C+N&rft.aulast=Volkow&rft.aufirst=N&rft.date=1999-09-01&rft.volume=156&rft.issue=9&rft.spage=1440&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Visualizing "greengold" clusters in the STEM. AN - 70852056; 10527905 AB - "Greengold" is a large metallic cluster thought to contain 75 gold atoms in a compact 1.4-nm-diameter core surrounded by an organic shell. Scanning transmission electron microscope imaging shows uniform mass and size distributions with an apparent mass of 24 kDa, unaffected by radiation damage. The signal-to-noise ratio is adequate for visualization at low dose and in the presence of a relatively thick biological matrix. Under some conditions these clusters have a slight tendency to form linear chains and 2-D hexagonal arrays with a spacing of 2.6 nm. The parameters presented permit estimation of the feasibility of proposed labeling experiments. JF - Journal of structural biology AU - Wall, J S AD - Biology Department, Brookhaven National Laboratory, Building 463, Upton, New York 11973, USA. Y1 - 1999/09// PY - 1999 DA - September 1999 SP - 161 EP - 168 VL - 127 IS - 2 SN - 1047-8477, 1047-8477 KW - Gold Compounds KW - 0 KW - Organometallic Compounds KW - Index Medicus KW - Tobacco Mosaic Virus -- chemistry KW - Signal Processing, Computer-Assisted KW - Tobacco Mosaic Virus -- radiation effects KW - Dose-Response Relationship, Radiation KW - Color KW - Microscopy, Electron, Scanning Transmission -- methods KW - Gold Compounds -- chemistry KW - Organometallic Compounds -- radiation effects KW - Organometallic Compounds -- chemistry KW - Image Processing, Computer-Assisted -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70852056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+structural+biology&rft.atitle=Visualizing+%22greengold%22+clusters+in+the+STEM.&rft.au=Wall%2C+J+S&rft.aulast=Wall&rft.aufirst=J&rft.date=1999-09-01&rft.volume=127&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Journal+of+structural+biology&rft.issn=10478477&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-12-17 N1 - Date created - 1999-12-17 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Spectral regions contributing to melanoma: a personal view. AN - 69212777; 10537007 AB - Although human cutaneous melanoma is a complicated disease, the principal etiologic agent for its incidence in fair skin individuals is exposure to sunlight. In order to understand the epidemiology of melanoma - temporal effects, latitude effects, sunscreen effects, albino susceptibility, and differences from nonmelanoma skin cancer -one must approach the problem by obtaining clues indicating which wavelengths in sunlight are effective in inducing melanomas. One way is to use an animal model. At present, the only suitable model is a backcross hybrid of small tropical fish of the genus Xiphophorus, bred to have only one tumor suppressor gene. Single UV exposures to 7-d-old fish induce melanomas readily observable by 4 mo. The initial slopes of dose-response curves for exposures at 302, 313, 365, 405, 436, and 547 nm yield sensitivity as a function of wavelength. This action spectrum does not look like the spectrum for light absorption by DNA (mostly in the UVB), but has appreciable sensitivities in the UVA and visible regions, and looks like a direct effect of light on DNA plus a large indirect effect on DNA by absorption of light by the intracellular melanin. Because the UVB is only a fraction of solar irradiance, one may calculate that 90% of melanoma induction in humans arises from UVA and visible, assuming the human spectrum is similar to the fish spectrum. The implications of this calculation are that (i) depletion of stratospheric ozone will not affect melanoma incidence, (ii) an increase in sun exposure time as a result of using UVB sunscreens could increase the risk of melanoma, and (iii) the use of high UVA sun tanning devices could increase the risk of melanoma. JF - The journal of investigative dermatology. Symposium proceedings AU - Setlow, R B AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. setlow@bnl.gov Y1 - 1999/09// PY - 1999 DA - September 1999 SP - 46 EP - 49 VL - 4 IS - 1 SN - 1087-0024, 1087-0024 KW - Sunscreening Agents KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Age Factors KW - Humans KW - Incidence KW - Disease Models, Animal KW - Genetic Predisposition to Disease KW - DNA Damage -- genetics KW - Skin Neoplasms -- etiology KW - Melanoma -- etiology KW - Neoplasms, Radiation-Induced KW - Light UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69212777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+investigative+dermatology.+Symposium+proceedings&rft.atitle=Spectral+regions+contributing+to+melanoma%3A+a+personal+view.&rft.au=Setlow%2C+R+B&rft.aulast=Setlow&rft.aufirst=R&rft.date=1999-09-01&rft.volume=4&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=The+journal+of+investigative+dermatology.+Symposium+proceedings&rft.issn=10870024&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-17 N1 - Date created - 1999-11-17 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Modeling of thermal hydraulic instabilities in single heated channel loop during startup transients AN - 17592506; 4706889 AB - A thermal hydraulics computer code was developed to simulate the geysering instability in a natural circulation system starting from subcooled conditions and to assess the impact of the system pressure and channel inlet subcooling on the inception of instability. The formulation of thermal hydraulics is inherently general and accounts for both single-phase liquid flow and nonhomogeneous, nonequilibrium two-phase flow. The computer code is based on momentum integral method where the current practice of basing fluid properties on the system averaged pressure has been relaxed and the local properties are based on local pressures estimated using the shape of steady-state pressure distribution, thereby, improving the predictions while preserving the computation speed, one of the important strength of the integral methods. This is an important modeling feature since the local vapor generation rate depends on local saturation temperature The methodology has been validated with the experiments conducted to investigate the instabilities in a low pressure natural circulation loop at low powers and high inlet subcoolings. The numerical simulations predicted periodic channel flow reversal, which is one of the feature of condensation-induced geysering. Basing local properties on local pressures instead of system average pressure led to decrease in the discrepancy in the prediction of the positive side amplitude from 40% to 6% and in the frequency from - 15% to 5%. In addition, it was observed that the start-up instability can be avoided by increasing system pressure or by decreasing channel inlet subcooling. This study showed that the integral method coupled with local pressure variation for the vapor generation model is suitable to predict startup or geysering transients. JF - Nuclear Engineering and Design AU - Paniagua, J AU - Rohatgi, U S AU - Prasad, V AD - Department of Mechanical Engineering, State University of New York, Stony Brook, NY 11794-2300, USA, rohatgi@bnl.gov Y1 - 1999/09// PY - 1999 DA - Sep 1999 SP - 207 EP - 226 VL - 193 IS - 1-2 SN - 0029-5493, 0029-5493 KW - Health & Safety Science Abstracts KW - Hydraulics KW - Nuclear reactors KW - Thermodynamics KW - Simulation KW - Computer applications KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17592506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Engineering+and+Design&rft.atitle=Modeling+of+thermal+hydraulic+instabilities+in+single+heated+channel+loop+during+startup+transients&rft.au=Paniagua%2C+J%3BRohatgi%2C+U+S%3BPrasad%2C+V&rft.aulast=Paniagua&rft.aufirst=J&rft.date=1999-09-01&rft.volume=193&rft.issue=1-2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Nuclear+Engineering+and+Design&rft.issn=00295493&rft_id=info:doi/10.1016%2FS0029-5493%2899%2900156-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Thermodynamics; Hydraulics; Nuclear reactors; Simulation; Computer applications DO - http://dx.doi.org/10.1016/S0029-5493(99)00156-9 ER - TY - JOUR T1 - Backbone Dynamics of the N-Terminal Domain in E. Coli DnaJ Determined by super(15)N- and super(13)CO-Relaxation Measurements AN - 17381504; 4601326 AB - The backbone dynamics of the N-terminal domain of the chaperone protein Escherichia coli DnaJ have been investigated using steady-state super(1)H- super(15)N NOEs, super(15)N T sub(1), T sub(2), and T sub(1 rho ) relaxation times, steady-state super(13)C super( alpha )- super(13)CO NOEs, and super(13)CO T sub(1) relaxation times. Two recombinant constructs of the N-terminal domain of DnaJ have been studied. One, DnaJ(1-78), contains the most conserved "J-domain" of DnaJ, and the other, DnaJ(1-104), includes a glycine/phenylalanine rich region ("G/F" region) in addition to the "J-domain". DnaJ(1-78) is not capable of stimulating ATP hydrolysis by DnaK, despite the fact that all currently identified sites responsible for DnaJ-DnaK interaction are located in this region. DnaJ(1-104), on the other hand, retains nearly the full ATPase stimulatory activity of full length DnaJ. Recently, a structural analysis of these two molecules was presented in an effort to elucidate the origin of their functional differences [Huang, K., Flanagan, J. M., and Prestegard, J. H. (1999) Protein Science 8, 203-214]. Herein, an analysis of dynamic properties is presented in a similar effort. A generalized model-free approach with a full treatment of the anisotropic overall rotation of the proteins is used in the analysis of measured relaxation parameters. Our results show that internal motions on pico- to nanosecond time scales in the backbone of DnaJ(1-78) are reduced on the inclusion of the "G/F" region, while conformational exchange on micro- to millisecond time scales increases. We speculate that the enhanced flexibility of residues on the slow time scale upon the inclusion of the "G/F" region could be relevant to the ATPase stimulatory activity of DnaJ if an "induced-fit" mechanism applies to DnaJ-DnaK interactions. JF - Biochemistry (Washington) AU - Huang, K AU - Ghose, R AU - Flanagan, J M AU - Prestegard, J H AD - Complex Carbohydrate Research Center, University of Georgia, 220 Riverbend Road, Athens, Georgia 30602-4712, flanagan@bnlbio.bio.bnl.gov Y1 - 1999/08/10/ PY - 1999 DA - 1999 Aug 10 SP - 10567 EP - 10577 VL - 38 IS - 32 SN - 0006-2960, 0006-2960 KW - domains KW - DnaJ protein KW - Microbiology Abstracts B: Bacteriology KW - Escherichia coli KW - Chaperones KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17381504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Backbone+Dynamics+of+the+N-Terminal+Domain+in+E.+Coli+DnaJ+Determined+by+super%2815%29N-+and+super%2813%29CO-Relaxation+Measurements&rft.au=Huang%2C+K%3BGhose%2C+R%3BFlanagan%2C+J+M%3BPrestegard%2C+J+H&rft.aulast=Huang&rft.aufirst=K&rft.date=1999-08-10&rft.volume=38&rft.issue=32&rft.spage=10567&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi990263%2B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Chaperones DO - http://dx.doi.org/10.1021/bi990263+ ER - TY - JOUR T1 - Positron emission tomography studies of dopamine-enhancing drugs. AN - 69933935; 10434242 AB - Although PET is technologically complex because the restricted time scale requires that radioisotope production, radiotracer synthesis, and PET imaging be carried out in the same place, the payoff is that compounds labeled with these isotopes can be used to track the distribution and movement of drugs in the brain and also measure drug effects on specific molecular targets in the human brain. Provided that appropriate radiotracers are available, one can determine the amount of a drug that gets into the brain, the minimum effective dose, the duration of action, or the binding site occupancy required to elicit a particular therapeutic or behavioral effect with a relatively small number of PET studies. Because studies are carried out directly in humans, the relationship of these parameters to behavior and to therapeutic efficacy can be evaluated. The possibilities are enormous and are largely driven by advances in PET technology (including radiotracer chemistry and instrumentation) that synergize with advances in neuropharmacology. JF - Journal of clinical pharmacology AU - Fowler, J S AU - Volkow, N D AU - Ding, Y S AU - Wang, G J AU - Dewey, S AU - Fischman, M W AU - Foltin, R AU - Hitzemann, R AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 13S EP - 16S VL - Suppl SN - 0091-2700, 0091-2700 KW - Carrier Proteins KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Dopamine Uptake Inhibitors KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Monoamine Oxidase Inhibitors KW - Nerve Tissue Proteins KW - Methylphenidate KW - 207ZZ9QZ49 KW - Selegiline KW - 2K1V7GP655 KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Selegiline -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Tomography, Emission-Computed KW - Drug Synergism KW - Monoamine Oxidase Inhibitors -- pharmacology KW - Carrier Proteins -- metabolism KW - Monoamine Oxidase -- metabolism KW - Cocaine -- metabolism KW - Dopamine Uptake Inhibitors -- metabolism KW - Methylphenidate -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69933935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Positron+emission+tomography+studies+of+dopamine-enhancing+drugs.&rft.au=Fowler%2C+J+S%3BVolkow%2C+N+D%3BDing%2C+Y+S%3BWang%2C+G+J%3BDewey%2C+S%3BFischman%2C+M+W%3BFoltin%2C+R%3BHitzemann%2C+R&rft.aulast=Fowler&rft.aufirst=J&rft.date=1999-08-01&rft.volume=Suppl&rft.issue=&rft.spage=13S&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-26 N1 - Date created - 1999-10-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The effects of boron neutron capture irradiation on oral mucosa: evaluation using a rat tongue model. AN - 69895867; 10409319 AB - The ventral surface of the tongue of male Fisher 344 rats was used to evaluate the response of oral mucosa to boron neutron capture irradiation. Three hours after i.p. injection of 700 mg/kg of the boron delivery agent p-boronophenylalanine (BPA), the boron concentrations in blood and tongue mucosal epithelium were approximately 21 and 23 microgram (10)B/g, respectively. The doses required to produce a 50% incidence of ulceration with X rays, the Brookhaven Medical Research Reactor thermal neutron beam alone, or the thermal neutron beam in the presence of BPA were 13.4 +/- 0.2, 4. 2 +/- 0.1, and 3.0 +/- 0.1 Gy, respectively. Ulceration of the tongue was evident by 6 to 7 days after irradiation, irrespective of the irradiation modality; healing was related to dose and was relatively rapid (70% occupancy of DAT by these drugs lead to a modest increase in occupancy of D2 receptors (25-30%), further studies are required to assess if this is an underestimation because of differences in D2 receptor binding kinetics between raclopride and DA. JF - Synapse AU - Volkow, N D AU - Fowler, J S AU - Gatley, S J AU - Dewey, S L AU - Wang, G-J AU - Logan, J AU - Ding, Y-S AU - Franceschi, D AU - Gifford, A AU - Morgan, A AU - Pappas, N AU - King, P AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA, volkow@bnl.gov Y1 - 1999/01// PY - 1999 DA - Jan 1999 SP - 59 EP - 66 VL - 31 IS - 1 SN - 0887-4476, 0887-4476 KW - baboons KW - methylphenidate KW - raclopride KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Synapses KW - Dopamine KW - Brain KW - Cocaine KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17251438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse&rft.atitle=Comparable+changes+in+synaptic+dopamine+induced+by+methylphenidate+and+by+cocaine+in+the+baboon+brain&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BGatley%2C+S+J%3BDewey%2C+S+L%3BWang%2C+G-J%3BLogan%2C+J%3BDing%2C+Y-S%3BFranceschi%2C+D%3BGifford%2C+A%3BMorgan%2C+A%3BPappas%2C+N%3BKing%2C+P&rft.aulast=Volkow&rft.aufirst=N&rft.date=1999-01-01&rft.volume=31&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Synapse&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Dopamine; Synapses; Brain; Cocaine ER - TY - JOUR T1 - Comparative studies of epibatidine derivatives [ super(18)F]NFEP and [ super(18)F]N-methyl-NFEP: Kinetics, nicotine effect, and toxicity AN - 17214854; 4503853 AB - We have previously shown that [ super(18)F]norchlorofluoroepibatidine ([ super(18)F]NFEP) would be an ideal radiotracer for positron emission tomography (PET) imaging of nicotinic acetylcholine receptors (nAChR); however, its high toxicity is a limiting factor for human studies. We, therefore, synthesized its N-methyl derivative ([ super(18)F]N-Me-NFEP) and carried out comparative studies. The distribution volumes for different brain regions were higher for [ super(18)F]N-Me-NFEP than those for [ super(18)F]NFEP (average: 52.5 plus or minus 0.9 vs. 36.4 plus or minus 0.7 for thalamus), though the distribution volume (DV) ratios were similar (3.93 plus or minus 0.27 vs. 3.65 plus or minus 0.19 for thalamus to cerebellum). Treatment with nicotine reduced the binding of both radiotracers. Toxicology studies in awake rats showed that N-methyl-NFEP has a lower mortality (0 vs. 30%) and smaller effect on plasma catecholamines than NFEP at a dose of 1.5 mu g/kg. However, marked alterations in cardiorespiratory parameters were observed after injection of N-methyl-NFEP (0.5 mu g/kg, IV) to an awake dog. Our results suggest that although the binding characteristics of [ super(18)F]NFEP and [ super(18)F]N-Me-NFEP appear to be ideally suited for PET imaging studies of the human brain, their relatively small safety margin will limit their use in humans. JF - Nuclear Medicine and Biology AU - Ding, Yu-Shin AU - Molina, P E AU - Fowler, J S AU - Logan, J AU - Volkow, N D AU - Kuhar, MJ AU - Carroll, F I AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA, ding@bnl.gov Y1 - 1999/01// PY - 1999 DA - Jan 1999 SP - 139 EP - 148 VL - 26 IS - 1 SN - 0969-8051, 0969-8051 KW - epibatidine KW - rats KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Nicotine KW - Neurotoxicity KW - Positron emission tomography KW - Brain KW - Acetylcholine receptors (nicotinic) KW - X 24114:Metabolism KW - N3 11104:Mammals (except primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17214854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Medicine+and+Biology&rft.atitle=Comparative+studies+of+epibatidine+derivatives+%5B+super%2818%29F%5DNFEP+and+%5B+super%2818%29F%5DN-methyl-NFEP%3A+Kinetics%2C+nicotine+effect%2C+and+toxicity&rft.au=Ding%2C+Yu-Shin%3BMolina%2C+P+E%3BFowler%2C+J+S%3BLogan%2C+J%3BVolkow%2C+N+D%3BKuhar%2C+MJ%3BCarroll%2C+F+I&rft.aulast=Ding&rft.aufirst=Yu-Shin&rft.date=1999-01-01&rft.volume=26&rft.issue=1&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Nuclear+Medicine+and+Biology&rft.issn=09698051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Nicotine; Brain; Neurotoxicity; Acetylcholine receptors (nicotinic); Positron emission tomography ER - TY - JOUR T1 - Side-looking underground radar (SLUR); physical modeling and case history AN - 52515176; 1999-014882 AB - A modification of conventional surface ground-penetrating radar (GPR) was conceived, tested, and successfully applied in the field at Brookhaven National Laboratory (BNL) to investigate waste pits. The modified GPR method consists of making measurements along a traverse line in a sloping trench with the radar's antenna oriented at an angle of up to 45 degrees from the horizontal. The direction of propagation of the electromagnetic field for this configuration is not vertical, and the amount of energy scattered from objects that are oriented vertically relative to the energy scattered from horizontal layers is increased. This fundamental feature of side-looking underground radar (SLUR) measurements is illustrated by physical modeling. Measurements made along parallel trenches that are offset at different distances from a vertically oriented object provides GPR cross-sections with a primary plane of investigation that intersects the vertical feature at different depths. SLUR was used at BNL in conjunction with conventional surface GPR measurements (displayed as 3-D blocks and plan-view time slices) to enhance the vertical definition and improve the depth estimates of the waste pits. JF - Geophysics AU - Daniels, Jeffrey J AU - Brower, James Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 1925 EP - 1932 PB - Society of Exploration Geophysicists, Tulsa, OK VL - 63 IS - 6 SN - 0016-8033, 0016-8033 KW - United States KW - experimental studies KW - geophysical surveys KW - Brookhaven National Laboratory KW - ground-penetrating radar KW - geophysical methods KW - radar methods KW - environmental analysis KW - Suffolk County New York KW - models KW - case studies KW - New York KW - surveys KW - geophysical profiles KW - electromagnetic field KW - waste disposal KW - Upton New York KW - side-looking radar KW - accuracy KW - field studies KW - 20:Applied geophysics KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52515176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysics&rft.atitle=Side-looking+underground+radar+%28SLUR%29%3B+physical+modeling+and+case+history&rft.au=Daniels%2C+Jeffrey+J%3BBrower%2C+James&rft.aulast=Daniels&rft.aufirst=Jeffrey&rft.date=1998-12-01&rft.volume=63&rft.issue=6&rft.spage=1925&rft.isbn=&rft.btitle=&rft.title=Geophysics&rft.issn=00168033&rft_id=info:doi/10.1190%2F1.1444485 L2 - http://library.seg.org/journal/gpysa7 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 9 N1 - PubXState - OK N1 - Document feature - illus. N1 - Last updated - 2013-06-13 N1 - CODEN - GPYSA7 N1 - SubjectsTermNotLitGenreText - accuracy; Brookhaven National Laboratory; case studies; electromagnetic field; environmental analysis; experimental studies; field studies; geophysical methods; geophysical profiles; geophysical surveys; ground-penetrating radar; models; New York; radar methods; side-looking radar; Suffolk County New York; surveys; United States; Upton New York; waste disposal DO - http://dx.doi.org/10.1190/1.1444485 ER - TY - JOUR T1 - Assessment of the quality of the shipboard measurements of total alkalinity on the WOCE Hydrographic Program Indian Ocean CO (sub 2) survey cruises 1994-1996 AN - 52460201; 1999-048754 AB - In 1995, we participated in a number of WOCE Hydrographic Program cruises in the Indian Ocean as part of the Joint Global Ocean Flux Study (JGOFS) CO (sub 2) Survey sponsored by the Department of Energy (DOE). Two titration systems were used throughout this study to determine the pH, total alkalinity (TA) and total inorganic carbon dioxide (TCO (sub 2) ) of the samples collected during these cruises. The performance of these systems was monitored by making closed cell titration measurements on Certified Reference Materials (CRMs). A total of 962 titrations were made on six batches of CRMs during the cruises. The reproducibility calculated from these titrations was + or -0.007 in pH, + or -4.2 mu mol kg (super -1) in TA, and + or -4.1 mu mol kg (super -1) in TCO (sub 2) . The at-sea measurements on the CRMs were in reasonable agreement with laboratory measurements made on the same batches. These results demonstrate that the CRMs can be used as a reference standard for TA and to monitor the performance of titration systems at sea. Measurements made on the various legs of the cruise agreed to within 6 mu mol kg (super -1) at the 15 crossover points. The overall mean and standard deviation of the differences at all the crossovers are 2.1+ or -2.1 mu mol kg (super -1) . These crossover results are quite consistent with the overall reproducibility of the CRM analyses for TA (+ or -4 mu mol kg (super -1) ) over the duration of the entire survey. The TA results for the Indian Ocean cruises provide a reliable data set that when combined with TCO (sub 2) data can completely characterize the carbonate system. JF - Marine Chemistry AU - Millero, Frank J AU - Dickson, Andrew G AU - Eischeid, Greg AU - Goyet, Catherine AU - Guenther, Peter AU - Johnson, Kenneth M AU - Key, Robert M AU - Lee, Kitack AU - Purkerson, David AU - Sabine, Christopher L AU - Schottle, Rolf G AU - Wallace, Douglas W R AU - Lewis, Ernie AU - Winn, Christopher D Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 9 EP - 20 PB - Elsevier, Amsterdam VL - 63 IS - 1-2 SN - 0304-4203, 0304-4203 KW - programs KW - concentration KW - ocean circulation KW - sea water KW - monitoring KW - titration KW - data processing KW - hydrochemistry KW - measurement KW - carbon dioxide KW - WOCE Hydrographic Program KW - computer programs KW - laboratory studies KW - Indian Ocean KW - sampling KW - marine methods KW - quality control KW - alkalinity KW - geochemistry KW - accuracy KW - pH KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52460201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Chemistry&rft.atitle=Assessment+of+the+quality+of+the+shipboard+measurements+of+total+alkalinity+on+the+WOCE+Hydrographic+Program+Indian+Ocean+CO+%28sub+2%29+survey+cruises+1994-1996&rft.au=Millero%2C+Frank+J%3BDickson%2C+Andrew+G%3BEischeid%2C+Greg%3BGoyet%2C+Catherine%3BGuenther%2C+Peter%3BJohnson%2C+Kenneth+M%3BKey%2C+Robert+M%3BLee%2C+Kitack%3BPurkerson%2C+David%3BSabine%2C+Christopher+L%3BSchottle%2C+Rolf+G%3BWallace%2C+Douglas+W+R%3BLewis%2C+Ernie%3BWinn%2C+Christopher+D&rft.aulast=Millero&rft.aufirst=Frank&rft.date=1998-12-01&rft.volume=63&rft.issue=1-2&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Marine+Chemistry&rft.issn=03044203&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/03044203 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 1999-01-01 N1 - Number of references - 20 N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - MRCHBD N1 - SubjectsTermNotLitGenreText - accuracy; alkalinity; carbon dioxide; computer programs; concentration; data processing; geochemistry; hydrochemistry; Indian Ocean; laboratory studies; marine methods; measurement; monitoring; ocean circulation; pH; programs; quality control; sampling; sea water; titration; WOCE Hydrographic Program ER - TY - JOUR T1 - Coulometric total carbon dioxide analysis for marine studies; assessment of the quality of total inorganic carbon measurements made during the US Indian Ocean CO (sub 2) survey 1994-1996 AN - 52458845; 1999-048755 AB - Two single-operator multiparameter metabolic analyzers (SOMMA)-coulometry systems (I and II) for total carbon dioxide (TCO (sub 2) ) were placed on board the R/V Knorr for the US component of the Indian Ocean CO (sub 2) Survey in conjunction with the World Ocean Circulation Experiment-WOCE Hydrographic Program (WHP). The systems were used by six different measurement groups on 10 WHP Cruises beginning in December 1994 and ending in January 1996. A total of 18,828 individual samples were analyzed for TCO (sub 2) during the survey. This paper assesses the analytical quality of these data and the effect of several key factors on instrument performance. Data quality is assessed from the accuracy and precision of certified reference material (CRM) analyses from three different CRM batches. The precision of the method was 1.2 mu mol/kg. The mean and standard deviation of the differences between the known TCO (sub 2) for the CRM (certified value) and the CRM TCO (sub 2) determined by SOMMA-coulometry were -0.91+ or -0.58 (n = 470) and -1.01+ or -0.44 (n = 513) mu mol/kg for systems I and II, respectively, representing an accuracy of 0.05% for both systems. Measurements of TCO (sub 2) made on 12 crossover stations during the survey agreed to within 3 mu mol/kg with an overall mean and standard deviation of the differences of -0.78+ or -1.74 mu mol/kg (n = 600). The crossover results are therefore consistent with the precision of the CRM analyses. After 14 months of nearly continuous use, the accurate and the virtually identical performance statistics for the two systems indicate that the cooperative survey effort was extraordinarily successful and will yield a high quality data set capable of fulfilling the objectives of the survey. JF - Marine Chemistry AU - Johnson, Kenneth M AU - Dickson, Andrew G AU - Eischeid, Greg AU - Goyet, Catherine AU - Guenther, Peter AU - Key, Robert M AU - Millero, Frank J AU - Purkerson, David AU - Sabine, Christopher L AU - Schottle, Rolf G AU - Wallace, Douglas W R AU - Wilke, Richard J AU - Winn, Christopher D Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 21 EP - 37 PB - Elsevier, Amsterdam VL - 63 IS - 1-2 SN - 0304-4203, 0304-4203 KW - sea water KW - coulometry KW - data processing KW - carbon dioxide KW - laboratory studies KW - Indian Ocean KW - sampling KW - carbon KW - geochemistry KW - programs KW - concentration KW - ocean circulation KW - monitoring KW - titration KW - hydrochemistry KW - measurement KW - inorganic materials KW - WOCE Hydrographic Program KW - computer programs KW - sample preparation KW - marine methods KW - quality control KW - accuracy KW - instruments KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52458845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Chemistry&rft.atitle=Coulometric+total+carbon+dioxide+analysis+for+marine+studies%3B+assessment+of+the+quality+of+total+inorganic+carbon+measurements+made+during+the+US+Indian+Ocean+CO+%28sub+2%29+survey+1994-1996&rft.au=Johnson%2C+Kenneth+M%3BDickson%2C+Andrew+G%3BEischeid%2C+Greg%3BGoyet%2C+Catherine%3BGuenther%2C+Peter%3BKey%2C+Robert+M%3BMillero%2C+Frank+J%3BPurkerson%2C+David%3BSabine%2C+Christopher+L%3BSchottle%2C+Rolf+G%3BWallace%2C+Douglas+W+R%3BWilke%2C+Richard+J%3BWinn%2C+Christopher+D&rft.aulast=Johnson&rft.aufirst=Kenneth&rft.date=1998-12-01&rft.volume=63&rft.issue=1-2&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Marine+Chemistry&rft.issn=03044203&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/03044203 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 1999-01-01 N1 - Number of references - 16 N1 - Document feature - illus. incl. 4 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - MRCHBD N1 - SubjectsTermNotLitGenreText - accuracy; carbon; carbon dioxide; computer programs; concentration; coulometry; data processing; geochemistry; hydrochemistry; Indian Ocean; inorganic materials; instruments; laboratory studies; marine methods; measurement; monitoring; ocean circulation; programs; quality control; sample preparation; sampling; sea water; titration; WOCE Hydrographic Program ER - TY - JOUR T1 - Remediation of soils and wastes contaminated with uranium and toxic metals AN - 52336997; 2000-051007 JF - Environmental Science & Technology, ES & T AU - Francis, A J AU - Dodge, C J Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 3993 EP - 3998 PB - American Chemical Society, Washington, DC VL - 32 IS - 24 SN - 0013-936X, 0013-936X KW - soils KW - biodegradation KW - toxic materials KW - pollutants KW - sludge KW - photochemistry KW - pollution KW - techniques KW - Pseudomonas KW - remediation KW - radioactive waste KW - waste management KW - photodegradation KW - metals KW - bacteria KW - chemical properties KW - uranium KW - waste disposal KW - solid waste KW - actinides KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52336997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Remediation+of+soils+and+wastes+contaminated+with+uranium+and+toxic+metals&rft.au=Francis%2C+A+J%3BDodge%2C+C+J&rft.aulast=Francis&rft.aufirst=A&rft.date=1998-12-01&rft.volume=32&rft.issue=24&rft.spage=3993&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/ L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 30 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - actinides; bacteria; biodegradation; chemical properties; metals; microorganisms; photochemistry; photodegradation; pollutants; pollution; Pseudomonas; radioactive waste; remediation; sludge; soils; solid waste; techniques; toxic materials; uranium; waste disposal; waste management ER - TY - JOUR T1 - Processing contaminated dredged material from the Port of New York-New Jersey AN - 17362505; 4542064 AB - Shipping activities in the Port of New York-New Jersey are currently threatened by restrictions on dredging of navigational channels and private berthing areas because of concerns about the environmental effects caused by ocean disposal of the dredged material. Current proposals for solutions to the problem include ocean disposal of uncontaminated material, use of confined disposal facilities (both upland facilities and containment islands), subaqueous borrow pits, and processing and treatment for contaminated materials. A project to produce a complete "treatment train" for processing and decontaminating dredged material is described. The work is divided into several phases: treatability studies of commercial and nonproprietary technologies at volumes of 19 liters (bench scale) and up to 19 m super(3) (pilot scale); specification of a treatment train; and implementation of a large-scale facility that can process 76,000-382,000 m super(3) of dredged material per year. The goal is to achieve operational status for the facility by the end of 1999. JF - Estuaries AU - Stern, E A AU - Donato, K AU - Jones, K W AU - Clesceri, N L AD - United States Environmental, Protection Agency, Division of Environmental, Planning and Protection, Place Based Protection Branch, 290 Broadway, New York, NY 10007-1866, USA, kwj@bnl.gov Y1 - 1998/12// PY - 1998 DA - Dec 1998 SP - 646 EP - 651 PB - Estuarine Research Federation, 490 Chippingwood Dr. No. 2 Port Republic MD 20676-2140 USA VL - 21 IS - 4A SN - 0160-8347, 0160-8347 KW - USA, New Jersey KW - USA, New York KW - Water Resources Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Ships KW - Ocean dumping KW - Marine KW - Dredge spoil KW - Sediment pollution KW - Ocean Dumping KW - Waste Disposal KW - Waste treatment KW - Navigation KW - Dredging KW - Sediment Contamination KW - Waste disposal KW - ANW, USA, Northeast KW - Harbors KW - Pollution control KW - SW 3070:Water quality control KW - O 4080:Pollution - Control and Prevention KW - Q5 08505:Prevention and control KW - Q2 09384:Dredging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17362505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Estuaries&rft.atitle=Processing+contaminated+dredged+material+from+the+Port+of+New+York-New+Jersey&rft.au=Stern%2C+E+A%3BDonato%2C+K%3BJones%2C+K+W%3BClesceri%2C+N+L&rft.aulast=Stern&rft.aufirst=E&rft.date=1998-12-01&rft.volume=21&rft.issue=4A&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=Estuaries&rft.issn=01608347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Ocean dumping; Sediment pollution; Dredge spoil; Waste treatment; Waste disposal; Pollution control; Ships; Ocean Dumping; Waste Disposal; Sediment Contamination; Dredging; Navigation; Harbors; ANW, USA, Northeast; Marine ER - TY - JOUR T1 - CNI-1493 attenuates hemodynamic and pro-inflammatory responses to LPS. AN - 70083546; 9840647 AB - The increased production of pro-inflammatory cytokines and nitric oxide have been postulated to contribute to the deleterious sequella of LPS administration. To date, clinical strategies to control these responses using individual specific inhibitors have been disappointing. The aim of the present study was to determine whether a tetravalent guanylhydrazone compound (CNI-1493) attenuates LPS-induced stress responses by suppressing multiple inflammatory mediators. Rats were injected intravenously with either CNI-1493 (10 mg/kg) or vehicle (1 mL NaCl) 60 min prior to the injection of LPS (100 microg/100 g body weight). LPS produced a 20% decrease in mean arterial blood pressure and a significant increase in circulating TNF-alpha levels as well as in tissue content of TNF-alpha, IL-1beta, and IL-6. This was associated with a marked increase in lung and gut apoptosis and myeloperoxidase (MPO) activities as well as with an increase in lung and spleen nitric oxide end products (NOx). Pretreatment with CNI-1493 attenuated the LPS-induced drop in mean arterial blood pressure (MABP) and blunted (40%) the rise in circulating TNF-alpha levels. CNI-1493 attenuated the LPS-induced increase in tissue cytokine (TNF-alpha, IL-1beta, and IL-6) content in lung and spleen but did not alter that of liver or gut. CNI-1493 pretreatment protected both lung and gut from LPS-induced apoptosis and in addition attenuated the rise in MPO activity in the gut. These results suggest diverse effects of CNI-1493 that are tissue specific and that confer protection against the hemodynamic and inflammatory responses to LPS. JF - Shock (Augusta, Ga.) AU - Molina, P E AU - Qian, L AU - Schuhlein, D AU - Naukam, R AU - Wang, H AU - Tracey, K J AU - Abumrad, N N AD - Department of Surgery, North Shore University Hospital, Manhasset, New York 11030, USA. Molina@bnl.gov Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 329 EP - 334 VL - 10 IS - 5 SN - 1073-2322, 1073-2322 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cytokines KW - Hydrazones KW - Lipopolysaccharides KW - Nitric Oxide KW - 31C4KY9ESH KW - semapimod KW - 9SGW2H1K8P KW - Peroxidase KW - EC 1.11.1.7 KW - Index Medicus KW - Animals KW - Spleen -- metabolism KW - Peroxidase -- metabolism KW - Nitric Oxide -- metabolism KW - Lung -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Apoptosis -- drug effects KW - Peroxidase -- drug effects KW - Bacterial Infections -- pathology KW - Blood Pressure -- drug effects KW - Spleen -- drug effects KW - Bacterial Infections -- drug therapy KW - Male KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Hemodynamics -- drug effects KW - Cytokines -- blood KW - Cytokines -- drug effects KW - Hydrazones -- pharmacology KW - Lipopolysaccharides -- toxicity KW - Inflammation -- drug therapy KW - Cytokines -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70083546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Shock+%28Augusta%2C+Ga.%29&rft.atitle=CNI-1493+attenuates+hemodynamic+and+pro-inflammatory+responses+to+LPS.&rft.au=Molina%2C+P+E%3BQian%2C+L%3BSchuhlein%2C+D%3BNaukam%2C+R%3BWang%2C+H%3BTracey%2C+K+J%3BAbumrad%2C+N+N&rft.aulast=Molina&rft.aufirst=P&rft.date=1998-11-01&rft.volume=10&rft.issue=5&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Shock+%28Augusta%2C+Ga.%29&rft.issn=10732322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-18 N1 - Date created - 1999-02-18 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Regional cerebral metabolism in female alcoholics of moderate severity does not differ from that of controls. AN - 70077993; 9835307 AB - It is generally believed that women are more vulnerable to alcohol's toxic effects than men. Studies in male alcoholics have consistently shown reductions in brain glucose metabolism. However, such studies have not been done in female alcoholics. The purpose of this study was to evaluate if similar or worse brain metabolic abnormalities occurred in female alcoholics. For this purpose, we measured regional brain metabolism with positron emission tomography and [18F]fluorodeoxyglucose in 10 recently detoxified female alcoholics and compared it with that in 12 age-matched female controls. There were no differences between alcoholics and control females in regional brain glucose metabolism whether we used regions of interest analysis or statistical parameter maps methods. These results do not support a higher toxicity for the effects of alcohol in the female brain, as assessed with regional brain glucose metabolism, because metabolic values in female alcoholics did not differ from those of controls, whereas metabolic values in male alcoholics are generally lower than those in controls. However, this study is confounded by the fact that the severity of alcohol use in these female alcoholics was less than that of the male alcoholics previously investigated in positron emission tomography studies. Future studies in male subjects with alcoholism of moderate severity are required to address gender differences in sensitivity to alcohol effects in brain metabolism. JF - Alcoholism, clinical and experimental research AU - Wang, G J AU - Volkow, N D AU - Fowler, J S AU - Pappas, N R AU - Wong, C T AU - Pascani, K AU - Felder, C A AU - Hitzemann, R J AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 1850 EP - 1854 VL - 22 IS - 8 SN - 0145-6008, 0145-6008 KW - Blood Glucose KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Index Medicus KW - Reference Values KW - Brain Mapping KW - Sex Factors KW - Humans KW - Fluorodeoxyglucose F18 -- metabolism KW - Adult KW - Middle Aged KW - Male KW - Female KW - Blood Glucose -- metabolism KW - Alcoholism -- diagnostic imaging KW - Brain -- drug effects KW - Tomography, Emission-Computed KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70077993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Regional+cerebral+metabolism+in+female+alcoholics+of+moderate+severity+does+not+differ+from+that+of+controls.&rft.au=Wang%2C+G+J%3BVolkow%2C+N+D%3BFowler%2C+J+S%3BPappas%2C+N+R%3BWong%2C+C+T%3BPascani%2C+K%3BFelder%2C+C+A%3BHitzemann%2C+R+J&rft.aulast=Wang&rft.aufirst=G&rft.date=1998-11-01&rft.volume=22&rft.issue=8&rft.spage=1850&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-22 N1 - Date created - 1999-02-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - X-ray optics for synchrotron radiation; perfect crystals, mirrors and multilayers AN - 52340867; 2000-048933 JF - Acta Crystallographica, Section A: Foundations of Crystallography AU - Hart, Michael AU - Berman, Lonny A2 - Schenk, H. Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 850 EP - 858 PB - Munksgaard, Copenhagen VL - 54 IS - Part 6, No. 1 SN - 0108-7673, 0108-7673 KW - mirrors KW - experimental studies KW - technology KW - crystal structure KW - crystal growth KW - layered materials KW - synchrotron radiation KW - crystals KW - laboratory studies KW - X-rays KW - theoretical studies KW - optical properties KW - future KW - refractive index KW - design KW - 01A:General mineralogy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52340867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica%2C+Section+A%3A+Foundations+of+Crystallography&rft.atitle=X-ray+optics+for+synchrotron+radiation%3B+perfect+crystals%2C+mirrors+and+multilayers&rft.au=Hart%2C+Michael%3BBerman%2C+Lonny&rft.aulast=Hart&rft.aufirst=Michael&rft.date=1998-11-01&rft.volume=54&rft.issue=Part+6%2C+No.+1&rft.spage=850&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica%2C+Section+A%3A+Foundations+of+Crystallography&rft.issn=01087673&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 71 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACACEQ N1 - SubjectsTermNotLitGenreText - crystal growth; crystal structure; crystals; design; experimental studies; future; laboratory studies; layered materials; mirrors; optical properties; refractive index; synchrotron radiation; technology; theoretical studies; X-rays ER - TY - JOUR T1 - Wellhead protection area delineation using a coupled GIS and groundwater model AN - 51963567; 2003-052895 JF - Journal of Environmental Management AU - Vieux, B E AU - Mubaraki, M A AU - Brown, D Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 205 EP - 214 PB - Academic Press, London-New York VL - 54 IS - 3 SN - 0301-4797, 0301-4797 KW - United States KW - Concho Reserve KW - aquifer vulnerability KW - agricultural waste KW - public policy KW - data processing KW - water management KW - environmental analysis KW - drinking water KW - ground water KW - environmental management KW - geographic information systems KW - Canadian County Oklahoma KW - data bases KW - discharge KW - water use KW - protection KW - programs KW - water supply KW - pollutants KW - pollution KW - decision-making KW - aquifers KW - models KW - Oklahoma KW - wellhead protection KW - industrial waste KW - information systems KW - waste disposal KW - Indian reservations KW - 21:Hydrogeology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51963567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Management&rft.atitle=Wellhead+protection+area+delineation+using+a+coupled+GIS+and+groundwater+model&rft.au=Vieux%2C+B+E%3BMubaraki%2C+M+A%3BBrown%2C+D&rft.aulast=Vieux&rft.aufirst=B&rft.date=1998-11-01&rft.volume=54&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Management&rft.issn=03014797&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/03014797 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 16 N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - agricultural waste; aquifer vulnerability; aquifers; Canadian County Oklahoma; Concho Reserve; data bases; data processing; decision-making; discharge; drinking water; environmental analysis; environmental management; geographic information systems; ground water; Indian reservations; industrial waste; information systems; models; Oklahoma; pollutants; pollution; programs; protection; public policy; United States; waste disposal; water management; water supply; water use; wellhead protection ER - TY - JOUR T1 - High-spin to low-spin transitions in FeO and Fe (sub 2) O (sub 3) probed by high-resolution X-ray fluorescence spectroscopy AN - 51733216; 2005-025459 JF - Eos, Transactions, American Geophysical Union AU - Badro, James AU - Hemley, Russell J AU - Mao, Ho-kwang AU - Struzhkin, Viktor V AU - Shu, Jinfu AU - Shen, Guoyin AU - Kao, Chi-chang AU - Rueff, Jean-Pascal AU - Hu, Jingzhu AU - Anonymous Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 865 PB - American Geophysical Union, Washington, DC VL - 79 IS - 45, Suppl. SN - 0096-3941, 0096-3941 KW - lower mantle KW - experimental studies KW - technology KW - iron oxides KW - X-ray fluorescence spectra KW - oxides KW - mantle KW - phase transitions KW - spectra KW - instruments KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51733216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=High-spin+to+low-spin+transitions+in+FeO+and+Fe+%28sub+2%29+O+%28sub+3%29+probed+by+high-resolution+X-ray+fluorescence+spectroscopy&rft.au=Badro%2C+James%3BHemley%2C+Russell+J%3BMao%2C+Ho-kwang%3BStruzhkin%2C+Viktor+V%3BShu%2C+Jinfu%3BShen%2C+Guoyin%3BKao%2C+Chi-chang%3BRueff%2C+Jean-Pascal%3BHu%2C+Jingzhu%3BAnonymous&rft.aulast=Badro&rft.aufirst=James&rft.date=1998-11-01&rft.volume=79&rft.issue=45%2C+Suppl.&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1998 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - experimental studies; instruments; iron oxides; lower mantle; mantle; oxides; phase transitions; spectra; technology; X-ray fluorescence spectra ER - TY - JOUR T1 - A novel strategy for the treatment of cocaine addiction. AN - 73894685; 9723781 AB - Cocaine's addictive liability has been linked to its pharmacologic actions on mesotelencephalic dopamine (DA) reinforcement/reward pathways in the central nervous system (CNS). Dopaminergic transmission within these pathways is modulated by gamma-aminobutyric acid (GABA). With this knowledge, we examined the utility of gamma vinylGABA (GVG), a selective and irreversible inhibitor of GABA-transaminase (GABA-T) known to potentiate GABAergic inhibition, to alter cocaine's biochemical effects as well as its effects on behaviors associated with these biochemical changes. GVG significantly attenuated cocaine-induced increases in neostriatal synaptic DA in the non-human primate (baboon) brain as assessed by positron emission tomography (PET) and abolished both the expression and acquisition of cocaine-induced conditioned place preference (CPP). It had no effect on CPP for a food reward, the delivery of cocaine to the brain or locomotor activity. These findings suggest the possible therapeutic utility in cocaine addiction of a pharmacologic strategy targeted at the GABAergic neurotransmitter system, a system distinct from but functionally linked to the DA mesotelencephalic reward/reinforcement system. However, rather than targeting the GABA receptor complex with a direct GABA agonist, this novel approach with GVG takes advantage of the prolonged effects of an irreversible enzyme inhibitor that raises endogenous GABA levels without the addictive liability associated with GABA agonists acting directly at the receptor itself. Human trials with GVG are currently being developed to directly examine the utility of this novel strategy for the treatment of cocaine addiction. JF - Synapse (New York, N.Y.) AU - Dewey, S L AU - Morgan, A E AU - Ashby, C R AU - Horan, B AU - Kushner, S A AU - Logan, J AU - Volkow, N D AU - Fowler, J S AU - Gardner, E L AU - Brodie, J D AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Sld@bnl.gov Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 119 EP - 129 VL - 30 IS - 2 SN - 0887-4476, 0887-4476 KW - Dopamine Uptake Inhibitors KW - 0 KW - Enzyme Inhibitors KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - 4-Aminobutyrate Transaminase KW - EC 2.6.1.19 KW - Vigabatrin KW - GR120KRT6K KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Papio KW - Animals KW - Catalepsy -- chemically induced KW - Brain -- drug effects KW - Food KW - Brain -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Cocaine -- pharmacokinetics KW - Motor Activity -- drug effects KW - Dopamine Uptake Inhibitors -- pharmacokinetics KW - Female KW - Male KW - Enzyme Inhibitors -- therapeutic use KW - gamma-Aminobutyric Acid -- therapeutic use KW - 4-Aminobutyrate Transaminase -- antagonists & inhibitors KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- drug therapy KW - gamma-Aminobutyric Acid -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73894685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=A+novel+strategy+for+the+treatment+of+cocaine+addiction.&rft.au=Dewey%2C+S+L%3BMorgan%2C+A+E%3BAshby%2C+C+R%3BHoran%2C+B%3BKushner%2C+S+A%3BLogan%2C+J%3BVolkow%2C+N+D%3BFowler%2C+J+S%3BGardner%2C+E+L%3BBrodie%2C+J+D&rft.aulast=Dewey&rft.aufirst=S&rft.date=1998-10-01&rft.volume=30&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-11-16 N1 - Date created - 1998-11-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Transport of U- and Th-series radionuclides in groundwater AN - 853218381; 2011-020298 JF - Mineralogical Magazine AU - Tricca, A AU - Porcelli, D AU - Wasserburg, G J AU - Baskaran, M AU - Naidu, J A2 - Schott, Jacques Y1 - 1998/09// PY - 1998 DA - September 1998 SP - 1543 EP - 1544 PB - Mineralogical Society, London VL - 62A, PART 3 SN - 0026-461X, 0026-461X KW - United States KW - Quaternary KW - isotopes KW - radon KW - ground water KW - aquifers KW - Cenozoic KW - New York KW - radioactive isotopes KW - transport KW - noble gases KW - metals KW - thorium KW - Pleistocene KW - uranium KW - Long Island KW - actinides KW - 21:Hydrogeology KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853218381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mineralogical+Magazine&rft.atitle=Transport+of+U-+and+Th-series+radionuclides+in+groundwater&rft.au=Tricca%2C+A%3BPorcelli%2C+D%3BWasserburg%2C+G+J%3BBaskaran%2C+M%3BNaidu%2C+J&rft.aulast=Tricca&rft.aufirst=A&rft.date=1998-09-01&rft.volume=62A%2C+PART+3&rft.issue=&rft.spage=1543&rft.isbn=&rft.btitle=&rft.title=Mineralogical+Magazine&rft.issn=0026461X&rft_id=info:doi/ L2 - http://www.minersoc.org/pages/e_journals/minmag.html LA - English DB - GeoRef N1 - Conference title - V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2011-01-01 N1 - Number of references - 4 N1 - Last updated - 2012-06-07 N1 - CODEN - MNLMBB N1 - SubjectsTermNotLitGenreText - actinides; aquifers; Cenozoic; ground water; isotopes; Long Island; metals; New York; noble gases; Pleistocene; Quaternary; radioactive isotopes; radon; thorium; transport; United States; uranium ER - TY - JOUR T1 - In-situ X-ray scattering study of the calcite-water interface AN - 52154592; 2002-008924 JF - Mineralogical Magazine AU - Fenter, P AU - Geissbuhler, P AU - DiMasi, E AU - Strajer, G AU - Sorensen, L AU - Sturchio, N AU - Anonymous Y1 - 1998/09// PY - 1998 DA - September 1998 SP - 442 EP - 443 PB - Mineralogical Society, London VL - 62A, Part 1 SN - 0026-461X, 0026-461X KW - X-ray data KW - in situ KW - Brillouin spectra KW - mineral-water interface KW - spectra KW - wave dispersion KW - carbonates KW - calcite KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52154592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mineralogical+Magazine&rft.atitle=In-situ+X-ray+scattering+study+of+the+calcite-water+interface&rft.au=Fenter%2C+P%3BGeissbuhler%2C+P%3BDiMasi%2C+E%3BStrajer%2C+G%3BSorensen%2C+L%3BSturchio%2C+N%3BAnonymous&rft.aulast=Fenter&rft.aufirst=P&rft.date=1998-09-01&rft.volume=62A%2C+Part+1&rft.issue=&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Mineralogical+Magazine&rft.issn=0026461X&rft_id=info:doi/ L2 - http://www.minersoc.org/pages/e_journals/minmag.html LA - English DB - GeoRef N1 - Conference title - V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 4 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Brillouin spectra; calcite; carbonates; in situ; mineral-water interface; spectra; wave dispersion; X-ray data ER - TY - JOUR T1 - The impact of photovoltaics on CO sub(2) emissions' reduction in the U.S. AN - 17129885; 4435915 AB - The potential role of Photovoltaic (PV) technologies in reducing carbon dioxide (CO sub(2)) emissions in the United States was evaluated using MARKAL-MACRO, an energy-environment-economic systems model. The model uses a range of assumptions about future energy use and demand in the period 1990-2030, and provides a quantitative assessment of the prospects for PV in a competitive market. With the projected improvements in cost and efficiency, PV will compete favorably as a general source of electricity supply to the grid by about 2010 in the southwestern United States. This analysis indicates that PV has the potential to reach a total installed capacity of 140 GW by the year 2030, and to displace a cumulative 450 million metric tons of carbon emissions from 1995 to 2030. At the projected 2030 capacity, PV could displace over 64 million metric tons of carbon emissions a year. If constraints on carbon emissions are implemented, PV would become cost effective even at low solar insolation US regions, and would further reduce carbon emissions from the US energy system. JF - World Resource Review AU - Fthenakis, V M AU - Lee, J C AD - Biomedical and Environmental Assessment Group, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 1998/09// PY - 1998 DA - Sep 1998 SP - 434 EP - 445 VL - 10 IS - 3 SN - 1042-8011, 1042-8011 KW - USA KW - Pollution Abstracts KW - Environmental economics KW - Emission control KW - Energy sources KW - Air pollution forecasting KW - Carbon dioxide KW - Solar energy KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17129885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+Resource+Review&rft.atitle=The+impact+of+photovoltaics+on+CO+sub%282%29+emissions%27+reduction+in+the+U.S.&rft.au=Fthenakis%2C+V+M%3BLee%2C+J+C&rft.aulast=Fthenakis&rft.aufirst=V&rft.date=1998-09-01&rft.volume=10&rft.issue=3&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=World+Resource+Review&rft.issn=10428011&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Energy sources; Solar energy; Environmental economics; Air pollution forecasting; Emission control; Carbon dioxide ER - TY - JOUR T1 - Interfaces between geothermal brine-induced scales and SiC-filled polymer linings AN - 52536832; 1999-002759 JF - Geothermics AU - Sugama, Toshifumi Y1 - 1998/08// PY - 1998 DA - August 1998 SP - 387 EP - 400 PB - Pergamon Press, Oxford - New York VL - 27 IS - 4 SN - 0375-6505, 0375-6505 KW - United States KW - thermal conductivity KW - power plants KW - heat exchange KW - carbides KW - production KW - infrared spectra KW - California KW - FTIR spectra KW - Salton Sea geothermal field KW - geothermal systems KW - energy sources KW - heat flow KW - alloys KW - spectra KW - chemical composition KW - polymers KW - geochemistry KW - corrosion KW - concentration KW - Imperial County California KW - geothermal fields KW - brines KW - efficiency KW - SEM data KW - 29B:Economic geology, economics of energy sources KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52536832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geothermics&rft.atitle=Interfaces+between+geothermal+brine-induced+scales+and+SiC-filled+polymer+linings&rft.au=Sugama%2C+Toshifumi&rft.aulast=Sugama&rft.aufirst=Toshifumi&rft.date=1998-08-01&rft.volume=27&rft.issue=4&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Geothermics&rft.issn=03756505&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/03756505 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - GTMCAT N1 - SubjectsTermNotLitGenreText - alloys; brines; California; carbides; chemical composition; concentration; corrosion; efficiency; energy sources; FTIR spectra; geochemistry; geothermal fields; geothermal systems; heat exchange; heat flow; Imperial County California; infrared spectra; polymers; power plants; production; Salton Sea geothermal field; SEM data; spectra; thermal conductivity; United States ER - TY - JOUR T1 - Radical nature of peroxynitrite reactivity. AN - 80022660; 9671530 JF - Chemical research in toxicology AU - Lymar, S V AU - Hurst, J K AD - Department of Chemistry, Washington State University, Pullman, Washington 99164-4630, and Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 1998/07// PY - 1998 DA - July 1998 SP - 714 EP - 715 VL - 11 IS - 7 SN - 0893-228X, 0893-228X KW - Free Radicals KW - 0 KW - Nitrates KW - Oxidants KW - peroxynitric acid KW - 26404-66-0 KW - Hydroxyl Radical KW - 3352-57-6 KW - Index Medicus KW - Stereoisomerism KW - Hydroxyl Radical -- chemistry KW - Electrons KW - Chemistry, Physical KW - Kinetics KW - Chemical Phenomena KW - Free Radicals -- chemistry KW - Oxidants -- chemistry KW - Nitrates -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80022660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Radical+nature+of+peroxynitrite+reactivity.&rft.au=Lymar%2C+S+V%3BHurst%2C+J+K&rft.aulast=Lymar&rft.aufirst=S&rft.date=1998-07-01&rft.volume=11&rft.issue=7&rft.spage=714&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-21 N1 - Date created - 1998-09-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Evaluation of carborane-containing porphyrins as tumour targeting agents for boron neutron capture therapy. AN - 69960114; 9771389 AB - A number of carborane-containing porphyrins were administered to mice bearing subcutaneously transplanted mammary carcinomas. Administration was via serial intraperitoneal (i.p.) injections to assess their relative toxicities and tumour affinities. Three analogues of the natural porphyrin heme and four tetraphenylporphyrins (TPPs) were given at total doses of 78-245 micrograms g-1 body weight. The water-insoluble TPPs were less toxic to mice, and delivered greater amounts of boron to tumour than did the water-soluble TPPS and the heme analogues. One such compound, NiTCP-H, delivered more than 100 micrograms B g-1 to tumour tissue with a tumour:blood boron concentration ratio greater than 500:1 and a tumour: brain boron concentration ratio greater than 50:1, 4 days after the last of six i.p. injections given over 2 days. Another TPP analogue, NiTCP, delivered approximately 50 micrograms B g-1 to tumour with similar boron concentrations in normal tissues. Neither compound was toxic to mice at total doses of approximately 200 micrograms g-1 body weight. In contrast, the heme analogues were toxic and, with the exception of VCDP, delivered less boron to tumour than NiTCP and NiTCP-H. The two porphyrins with the greatest potential for application to boron neutron capture therapy (BNCT), NiTCP and NiTCP-H, yielded higher tumour:blood and tumour:brain boron concentration ratios in mice than could be achieved with p-boronophenylalanine (BPA) and sodium mercaptoundecahydrododecaborate (BSH), the compounds which are currently being used in clinical trials of BNCT in the treatment of glioblastoma. The boron delivered by each of the porphyrins tested remained in tumour tissue longer than did boron delivered by either BPA or BSH. The copper and nickel chelates of these porphyrins behave identically in vivo. The former offer the potential for imaging by 67Cu-mediated single photon emission computed tomography (SPECT) to aid BNCT treatment planning. JF - The British journal of radiology AU - Miura, M AU - Micca, P L AU - Fisher, C D AU - Gordon, C R AU - Heinrichs, J C AU - Slatkin, D N AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 1998/07// PY - 1998 DA - July 1998 SP - 773 EP - 781 VL - 71 IS - 847 SN - 0007-1285, 0007-1285 KW - Boron Compounds KW - 0 KW - Porphyrins KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Transplantation KW - Molecular Structure KW - Animals KW - Dose-Response Relationship, Drug KW - Weight Loss -- drug effects KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Porphyrins -- toxicity KW - Boron Compounds -- toxicity KW - Boron Compounds -- pharmacokinetics KW - Porphyrins -- chemistry KW - Mammary Neoplasms, Experimental -- radiotherapy KW - Boron Neutron Capture Therapy -- methods KW - Mammary Neoplasms, Experimental -- metabolism KW - Porphyrins -- pharmacokinetics KW - Boron Compounds -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69960114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+radiology&rft.atitle=Evaluation+of+carborane-containing+porphyrins+as+tumour+targeting+agents+for+boron+neutron+capture+therapy.&rft.au=Miura%2C+M%3BMicca%2C+P+L%3BFisher%2C+C+D%3BGordon%2C+C+R%3BHeinrichs%2C+J+C%3BSlatkin%2C+D+N&rft.aulast=Miura&rft.aufirst=M&rft.date=1998-07-01&rft.volume=71&rft.issue=847&rft.spage=773&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+radiology&rft.issn=00071285&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-10-19 N1 - Date created - 1998-10-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Acyclic isoprenoids - molecular indicators of archaeal activity in contemporary and ancient Chinese saline/hypersaline environments AN - 17354765; 4517076 AB - Acyclic isoprenoid hydrocarbons are found to be the predominant components in the organic matter extracted from sedimentary cores and oils of various hypersaline settings, including Tertiary Janghan salt lake basin, Cretaceous Taian salt lake basin, and Triassic, Permian and Cambrian Yangtze evaporitic marine platform. Inland saline lake basins are characterized by tremendous predominance of phytane (iC sub(20)) ranging up to 15% of the total extract. While the evaporitic marine sediments are unique for their complete series of super-long-chain acyclic isoprenoids, up to C sub(40). These isoprenoids possess head-to-head, tail-to-tail or regular linkages and generally are indicators of the significant contribution from various archaea (archaebacteria), i.e. halophiles, methanogens and acidothermophiles. According to the great discrepancy of distribution and composition of isoprenoids, these modern and Cenozoic inland salt lake sediments are likely dominated by halophilic archaea, while the studied Mesozoic and Paleozoic evaporitic marine sediments are predominantly distinguished by methanogens and acidothermophiles. Concentration of chlorine salt is more directly proportional to the abundance of phytane than sulfate. Reduced species of sulfur, sulfide, S super(0) and organic sulfur compounds (OSC), however, may have played a key role in the preservation and formation of the highly abundant phytane observed in the inland salt lake basins. JF - Hydrobiologia AU - Wang, Ruiliang AD - 535A, Brookhaven National Laboratory, Upton, NY 11973, USA A2 - Mianping, Zheng A2 - Hurlbert, SH A2 - Williams, WD (eds) Y1 - 1998/07// PY - 1998 DA - Jul 1998 SP - 59 EP - 76 PB - Kluwer Academic Publishers, Postbus 17 Dordrecht 3300 AA Netherlands VL - 381 IS - 1-3 SN - 0018-8158, 0018-8158 KW - isoprenoids KW - Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Bacteria KW - Hydrocarbons KW - Lake Sediments KW - Lake basins KW - Palaeoenvironments KW - Indicators KW - Salt lakes KW - Salts KW - Saline Lakes KW - Marine Sediments KW - Organic Matter KW - Cores KW - Saline water KW - China, People's Rep. KW - Lake Basins KW - Q2 09148:Palaeo-studies KW - SW 0850:Lakes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17354765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrobiologia&rft.atitle=Acyclic+isoprenoids+-+molecular+indicators+of+archaeal+activity+in+contemporary+and+ancient+Chinese+saline%2Fhypersaline+environments&rft.au=Wang%2C+Ruiliang&rft.aulast=Wang&rft.aufirst=Ruiliang&rft.date=1998-07-01&rft.volume=381&rft.issue=1-3&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Hydrobiologia&rft.issn=00188158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Hydrocarbons; Lake basins; Indicators; Palaeoenvironments; Saline water; Salt lakes; Bacteria; Salts; Marine Sediments; Saline Lakes; Cores; Organic Matter; Lake Sediments; Lake Basins; China, People's Rep. ER - TY - JOUR T1 - Photochemistry of O sub(3) and related compounds over southern Nova Scotia AN - 16131023; 4448969 AB - Photochemical model calculations have been performed for air masses encountered by the National Research Council's Twin Otter aircraft during the 1993 summer North Atlantic Regional Experiment (NARE) intensive. These calculations use observed values of O sub(3), NO sub(y), CO, and hydrocarbons as constraints. NO is determined using the ratio NO/NO sub(y) measured from the National Center for Atmospheric Research King Air under comparable circumstances. Measurements over coastal locations indicate photochemically aged air masses with relatively low concentrations of NO and an OH reactivity that is dominated by CO and CH sub(4). Samples over land have higher NO and an OH reactivity that is dominated by isoprene. Ozone production rates and H sub(2)O sub(2) concentrations are analyzed using radical budget arguments that are applicable to low NO sub(x) conditions. The ozone production rate, P(O sub(3)), is predicted to be proportional to Q super(1/2)[NO], where Q is the production rate for free radicals. This relation explains 99% of the variance in P(O sub(3)). Over 90% of the variance is explained by [NO] alone. P(O sub(3)) in the coastal samples is about a factor of 4 lower than previous estimates for the eastern United States. This is a consequence of low [NO] in the air masses that are advected to Nova Scotia. JF - Journal of Geophysical Research. D. Atmospheres AU - Kleinman, LI AU - Daum, PH AU - Lee, J H AU - Lee, Y-N AU - Weinstein-Lloyd, J AU - Springston AU - Buhr, M AU - Jobson, B T AD - Department of Applied Science, Environmental Chemistry Division, Brookhaven National Laboratory Upton, NY, USA Y1 - 1998/06/20/ PY - 1998 DA - 1998 Jun 20 SP - 13519 EP - 13529 VL - 103 IS - D11 SN - 0148-0227, 0148-0227 KW - Canada, Nova Scotia KW - NARE II KW - Photochemical model KW - Pollution Abstracts; Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Photochemistry KW - Advection KW - ANW, North Atlantic KW - Ozone KW - Air masses KW - Marine KW - Pollution detection KW - Hydrocarbons KW - ANW, Canada, Nova Scotia KW - Atmospheric circulation KW - Air pollution KW - Coastal zone KW - Atmospheric chemistry KW - Analytical techniques KW - Nitrogen compounds KW - O 4095:Instruments/Methods KW - P 0000:AIR POLLUTION KW - Q2 02182:Methods and instruments KW - Q5 01502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16131023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.atitle=Photochemistry+of+O+sub%283%29+and+related+compounds+over+southern+Nova+Scotia&rft.au=Kleinman%2C+LI%3BDaum%2C+PH%3BLee%2C+J+H%3BLee%2C+Y-N%3BWeinstein-Lloyd%2C+J%3BSpringston%3BBuhr%2C+M%3BJobson%2C+B+T&rft.aulast=Kleinman&rft.aufirst=LI&rft.date=1998-06-20&rft.volume=103&rft.issue=D11&rft.spage=13519&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.issn=01480227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 1999-11-01 N1 - SuppNotes - Includes special section on the North Atlantic Regional Experiment (NARE II). N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Air pollution; Photochemistry; Air masses; Coastal zone; Pollution detection; Hydrocarbons; Analytical techniques; Atmospheric chemistry; Atmospheric circulation; Nitrogen compounds; Advection; Ozone; ANW, North Atlantic; ANW, Canada, Nova Scotia; Marine ER - TY - JOUR T1 - An acute dose of nicotine does not inhibit MAO B in baboon brain in vivo AN - 16419528; 4330098 AB - Tobacco smoke exposure has been shown to inhibit brain and platelet MAO B in animals and in humans. Though the mechanism(s) responsible for MAO B inhibition are not known, studies in rodents have shown that nicotine administration does not inhibit brain MAO B. In this study we investigated whether brain MAO B is also unaffected by nicotine in the living primate. Brain MAO B was measured with positron emission tomography (PET) and deuterium substituted [ super(11)C]L-deprenyl ([ super(11)C]L-deprenyl-D2) in three baboons at baseline and 5 minutes after the injection of (-)-nicotine (0.3 mg administered intravenously). A three-compartment model was used to calculate the plasma to brain transfer constant K sub(1) which is related to blood flow, and lambda k sub(3), which is a function of the concentration of catalytically active MAO B molecules. Nicotine administration did not produce significant changes in either of these parameters. This study in living baboons confirms previous studies in rodents and solidifies the notion that other mechanisms for MAO B inhibition observed in smokers need to be considered. JF - Life Sciences AU - Fowler, J S AU - Volkow, N D AU - Logan, J AU - Pappas, N AU - King, P AU - MacGregor, R AU - Shea, C AU - Garza, V AU - Gatley, S J AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-500, USA Y1 - 1998/06/05/ PY - 1998 DA - 1998 Jun 05 SP - 19 EP - 23 VL - 63 IS - 2 SN - 0024-3205, 0024-3205 KW - Papio KW - monoamine oxidase KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16419528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+Sciences&rft.atitle=An+acute+dose+of+nicotine+does+not+inhibit+MAO+B+in+baboon+brain+in+vivo&rft.au=Fowler%2C+J+S%3BVolkow%2C+N+D%3BLogan%2C+J%3BPappas%2C+N%3BKing%2C+P%3BMacGregor%2C+R%3BShea%2C+C%3BGarza%2C+V%3BGatley%2C+S+J&rft.aulast=Fowler&rft.aufirst=J&rft.date=1998-06-05&rft.volume=63&rft.issue=2&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Life+Sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - A determinant of substrate specificity predicted from the acyl-acyl carrier protein desaturase of developing cat's claw seed. AN - 79930682; 9625712 AB - Cat's claw (Doxantha unguis-cati L.) vine accumulates nearly 80% palmitoleic acid (16:1Delta9) plus cis-vaccenic acid (18:1Delta11) in its seed oil. To characterize the biosynthetic origin of these unusual fatty acids, cDNAs for acyl-acyl carrier protein (acyl-ACP) desaturases were isolated from developing cat's claw seeds. The predominant acyl-ACP desaturase cDNA identified encoded a polypeptide that is closely related to the stearoyl (Delta9-18:0)-ACP desaturase from castor (Ricinis communis L.) and other species. Upon expression in Escherichia coli, the cat's claw polypeptide functioned as a Delta9 acyl-ACP desaturase but displayed a distinct substrate specificity for palmitate (16:0)-ACP rather than stearate (18:0)-ACP. Comparison of the predicted amino acid sequence of the cat's claw enzyme with that of the castor Delta9-18:0-ACP desaturase suggested that a single amino acid substitution (L118W) might account in large part for the differences in substrate specificity between the two desaturases. Consistent with this prediction, conversion of leucine-118 to tryptophan in the mature castor Delta9-18:0-ACP desaturase resulted in an 80-fold increase in the relative specificity of this enzyme for 16:0-ACP. The alteration in substrate specificity observed in the L118W mutant is in agreement with a crystallographic model of the proposed substrate-binding pocket of the castor Delta9-18:0-ACP desaturase. JF - Plant physiology AU - Cahoon, E B AU - Shah, S AU - Shanklin, J AU - Browse, J AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11976, USA. Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 593 EP - 598 VL - 117 IS - 2 SN - 0032-0889, 0032-0889 KW - DNA, Complementary KW - 0 KW - Recombinant Proteins KW - Mixed Function Oxygenases KW - EC 1.- KW - acyl-(acyl-carrier-protein)desaturase KW - EC 1.14.19.2 KW - Index Medicus KW - Recombinant Proteins -- biosynthesis KW - Euphorbiaceae -- enzymology KW - Amino Acid Sequence KW - Cloning, Molecular KW - Mutagenesis, Site-Directed KW - Sequence Alignment KW - Plant Development KW - Recombinant Proteins -- metabolism KW - Molecular Sequence Data KW - Substrate Specificity KW - Recombinant Proteins -- chemistry KW - Sequence Homology, Amino Acid KW - Amino Acid Substitution KW - Mixed Function Oxygenases -- chemistry KW - Mixed Function Oxygenases -- metabolism KW - Mixed Function Oxygenases -- biosynthesis KW - Seeds -- enzymology KW - Plants -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79930682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plant+physiology&rft.atitle=A+determinant+of+substrate+specificity+predicted+from+the+acyl-acyl+carrier+protein+desaturase+of+developing+cat%27s+claw+seed.&rft.au=Cahoon%2C+E+B%3BShah%2C+S%3BShanklin%2C+J%3BBrowse%2C+J&rft.aulast=Cahoon&rft.aufirst=E&rft.date=1998-06-01&rft.volume=117&rft.issue=2&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Plant+physiology&rft.issn=00320889&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-27 N1 - Date created - 1998-07-27 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: J Biol Chem. 1968 Sep 10;243(17):4626-33 [4300868] Plant Physiol. 1997 Aug;114(4):1533-9 [9276960] Nucleic Acids Res. 1987 Aug 25;15(16):6643-53 [3628002] Gene. 1989 Apr 15;77(1):51-9 [2744487] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2510-4 [2006187] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2578-82 [2006194] Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11184-8 [1454797] Plant Mol Biol. 1994 Oct;26(2):679-90 [7948922] J Biol Chem. 1994 Nov 4;269(44):27519-26 [7961667] Arch Biochem Biophys. 1995 Jan 10;316(1):619-34 [7840674] Biochem Soc Trans. 1994 Nov;22(4):926-31 [7698486] Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8771-5 [8710947] EMBO J. 1996 Aug 15;15(16):4081-92 [8861937] Proc Natl Acad Sci U S A. 1997 May 13;94(10):4872-7 [9144157] Plant Mol Biol. 1997 Apr;33(6):1105-10 [9154992] J Biol Chem. 1979 Aug 10;254(15):7123-8 [379000] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Addiction and imaging of the living human brain. AN - 73857827; 9716933 JF - Drug and alcohol dependence AU - Gatley, S J AU - Volkow, N D AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. gatley@bnl.gov PY - 1998 SP - 97 EP - 108 VL - 51 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Central Nervous System Depressants KW - 0 KW - Central Nervous System Stimulants KW - Narcotics KW - Street Drugs KW - Ethanol KW - 3K9958V90M KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Magnetic Resonance Imaging KW - Central Nervous System Depressants -- pharmacology KW - Central Nervous System Stimulants -- pharmacology KW - Ethanol -- pharmacology KW - Humans KW - Cerebrovascular Circulation -- drug effects KW - Cocaine -- pharmacology KW - Narcotics -- pharmacology KW - Substance-Related Disorders -- physiopathology KW - Tomography, Emission-Computed, Single-Photon KW - Street Drugs -- pharmacology KW - Brain -- drug effects KW - Brain -- blood supply KW - Tomography, Emission-Computed KW - Brain -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73857827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Addiction+and+imaging+of+the+living+human+brain.&rft.au=Gatley%2C+S+J%3BVolkow%2C+N+D&rft.aulast=Gatley&rft.aufirst=S&rft.date=1998-06-01&rft.volume=51&rft.issue=1-2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-11-12 N1 - Date created - 1998-11-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Crystal structure-crystal chemistry relationships in the zeolites erionite and offretite AN - 52587618; 1998-046687 AB - This study clarifies the crystal structure variations and relationships in the zeolites erionite and offretite. The crystal structure analyses used Rietveld analysis of X-ray powder diffraction data, obtained both by synchrotron radiation and conventional X-ray sources, and on diffraction patterns obtained by transmission electron microscopy. The framework Al atoms in erionite are preferentially located in the single six-membered ring of tetrahedra (T2 site), whereas the Si-Al distribution is essentially disordered on the tetrahedral framework sites in offretite. In both zeolites, the center of the cancrinite cage is always occupied by K cations in similar amounts in both minerals. The erionite cage in erionite is occupied by Ca and Na atoms distributed on four distinct cation sites. Mg ions can be present up to 0.8 atoms per cell and are located between the Ca1 and Ca3 sites and very close to the Ca2 site on the symmetry axis. In offretite, the Mg site is located on the trigonal axis of the gmelinite cage and the Mg atoms are bonded to a variable number (five or six) of H (sub 2) O molecules, depending on the site population. The structural data and TEM analysis clearly show that the crystal chemistry of the extraframework cations, Mg in particular, is a major factor controlling whether erionite or offretite crystallizes, the Si-A1 distribution in the framework, and the possible stacking intergrowths of the two minerals. JF - American Mineralogist AU - Gualtieri, A AU - Artioli, G AU - Passaglia, E AU - Bigi, S AU - Viani, A AU - Hanson, J C Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 590 EP - 606 PB - Mineralogical Society of America, Washington, DC VL - 83 IS - 5-6 SN - 0003-004X, 0003-004X KW - silicates KW - refinement KW - erionite KW - X-ray diffraction data KW - zeolite group KW - offretite KW - framework silicates KW - crystal structure KW - crystal chemistry KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52587618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Crystal+structure-crystal+chemistry+relationships+in+the+zeolites+erionite+and+offretite&rft.au=Gualtieri%2C+A%3BArtioli%2C+G%3BPassaglia%2C+E%3BBigi%2C+S%3BViani%2C+A%3BHanson%2C+J+C&rft.aulast=Gualtieri&rft.aufirst=A&rft.date=1998-06-01&rft.volume=83&rft.issue=5-6&rft.spage=590&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 39 N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - crystal chemistry; crystal structure; erionite; framework silicates; offretite; refinement; silicates; X-ray diffraction data; zeolite group ER - TY - JOUR T1 - Comparative results of four (super 90) Sr groundwater analytical methods AN - 52071878; 2002-064455 JF - Health Physics AU - Scarpitta, S C AU - Odin-McCabe, J AU - Gaschott, R AU - Meir, A AU - Klug, E AU - Anonymous Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 46 PB - Pergamon, Long Island, NY VL - 74 IS - 6, Suppl. SN - 0017-9078, 0017-9078 KW - Sr-90 KW - concentration KW - alkaline earth metals KW - chemical analysis KW - isotopes KW - pollutants KW - pollution KW - gamma-ray spectroscopy KW - hydrochemistry KW - drinking water KW - measurement KW - ground water KW - radioactive isotopes KW - metals KW - gamma-ray spectra KW - spectra KW - spectroscopy KW - geochemistry KW - strontium KW - 02D:Isotope geochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52071878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Comparative+results+of+four+%28super+90%29+Sr+groundwater+analytical+methods&rft.au=Scarpitta%2C+S+C%3BOdin-McCabe%2C+J%3BGaschott%2C+R%3BMeir%2C+A%3BKlug%2C+E%3BAnonymous&rft.aulast=Scarpitta&rft.aufirst=S&rft.date=1998-06-01&rft.volume=74&rft.issue=6%2C+Suppl.&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ L2 - http://www.health-physics.com/pt/re/healthphys/home.htm;jsessionid=G5qSTXSp0vDSHYTCTzDnLVFQz7CBNyYYSGk1jRLYMGG4QvPYTKvJ!1240718814!-949856144!8091!-1 LA - English DB - GeoRef N1 - Conference title - Forty-third annual meeting of the Health Physics Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - NY N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - alkaline earth metals; chemical analysis; concentration; drinking water; gamma-ray spectra; gamma-ray spectroscopy; geochemistry; ground water; hydrochemistry; isotopes; measurement; metals; pollutants; pollution; radioactive isotopes; spectra; spectroscopy; Sr-90; strontium ER - TY - JOUR T1 - Total body chlorine: calibration of the in vivo neutron activation measurement. AN - 79829304; 9569536 AB - Total body chlorine (TBCI), used to estimate the extracellular space, is measured by delayed-gamma neutron activation (DGNA) using the reaction 37Cl(n, gamma)38Cl, at Brookhaven National Laboratory. During the calibration process, we noticed that different values were obtained when different amounts of Cl were placed in the phantom. This non-linear relationship is due to the thermal neutron flux suppression by the thermal neutron capture reaction 35Cl(n, gamma)36Cl. Monte Carlo simulations confirm the results of phantom measurements showing an inverse relationship between the Cl content in the phantom and the gamma-ray yield per gram Cl. Thus, it is important to calibrate the DGNA system for TBCl using phantom standards containing an amount of Cl close to that expected in the individual undergoing measurement. JF - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine AU - Ma, R AU - Yasumura, S AU - Moore, R I AU - Zhao, X AU - Rarback, H M AU - Lomonte, A F AU - Vodopia, K A AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11794, USA. PY - 1998 SP - 533 EP - 535 VL - 49 IS - 5-6 SN - 0969-8043, 0969-8043 KW - Radioisotopes KW - 0 KW - Chlorine KW - 4R7X1O2820 KW - Index Medicus KW - Computer Simulation KW - Reproducibility of Results KW - Gamma Rays KW - Humans KW - Neutron Activation Analysis -- methods KW - Calibration KW - Monte Carlo Method KW - Male KW - Female KW - Skeleton KW - Phantoms, Imaging KW - Extracellular Space KW - Chlorine -- analysis KW - Body Composition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79829304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+radiation+and+isotopes+%3A+including+data%2C+instrumentation+and+methods+for+use+in+agriculture%2C+industry+and+medicine&rft.atitle=Total+body+chlorine%3A+calibration+of+the+in+vivo+neutron+activation+measurement.&rft.au=Ma%2C+R%3BYasumura%2C+S%3BMoore%2C+R+I%3BZhao%2C+X%3BRarback%2C+H+M%3BLomonte%2C+A+F%3BVodopia%2C+K+A&rft.aulast=Ma&rft.aufirst=R&rft.date=1998-05-01&rft.volume=49&rft.issue=5-6&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Applied+radiation+and+isotopes+%3A+including+data%2C+instrumentation+and+methods+for+use+in+agriculture%2C+industry+and+medicine&rft.issn=09698043&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-05-28 N1 - Date created - 1998-05-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Removal of atmospheric CCl (sub 4) under bulk aerobic conditions in grounwater and soils AN - 52330102; 2000-052263 JF - Environmental Science & Technology, ES & T AU - Happell, James D AU - Annable, Michael D AU - Wallace, W R Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 1244 EP - 1252 PB - American Chemical Society, Washington, DC VL - 32 IS - 9 SN - 0013-936X, 0013-936X KW - United States KW - chlorinated hydrocarbons KW - aquifer vulnerability KW - Brookhaven National Laboratory KW - unsaturated zone KW - environmental analysis KW - remediation KW - ground water KW - Suffolk County New York KW - tracers KW - halogenated hydrocarbons KW - soils KW - concentration KW - pollutants KW - pollution KW - carbon tetrachloride KW - aquifers KW - water table KW - recharge KW - organic compounds KW - New York KW - detection KW - Lloyd Aquifer KW - Magothy Aquifer KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52330102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Removal+of+atmospheric+CCl+%28sub+4%29+under+bulk+aerobic+conditions+in+grounwater+and+soils&rft.au=Happell%2C+James+D%3BAnnable%2C+Michael+D%3BWallace%2C+W+R&rft.aulast=Happell&rft.aufirst=James&rft.date=1998-05-01&rft.volume=32&rft.issue=9&rft.spage=1244&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/ L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 50 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - aquifer vulnerability; aquifers; Brookhaven National Laboratory; carbon tetrachloride; chlorinated hydrocarbons; concentration; detection; environmental analysis; ground water; halogenated hydrocarbons; Lloyd Aquifer; Magothy Aquifer; New York; organic compounds; pollutants; pollution; recharge; remediation; soils; Suffolk County New York; tracers; United States; unsaturated zone; water table ER - TY - JOUR T1 - Direct evidence for a half-metallic ferromagnet AN - 815534750; 13760904 AB - Half-metallic materials are characterized by the coexistence of metallic behaviour for one electron spin and insulating behaviour for the other. Thus, the electronic density of states is completely spin polarized at the Fermi level, and the conductivity is dominated by these metallic single-spin charge carriers. This exotic physical property could have a significant effect on technological applications related to magnetism and spin electronics. Some ferromagnetic systems, such as Heusler compounds and chromium dioxide, have been predicted theoretically to be half-metallic. However, a half-metallic system has not been demonstrated directly and the predictions are still in doubt,. Here we report spin-resolved photoemission measurements of a ferromagnetic manganese perovskite, La sub(0.7)Sr sub(0.3)MnO sub(3), which directly manifest the half-metallic nature well below the Curie temperature. For the majority spin, the photoemission spectrum clearly shows a metallic Fermi cut-off, whereas for the minority spin, it shows an insulating gap with disappearance of spectral weight at 60.6eV binding energy. JF - Nature AU - Park, J-H AU - Vescovo, E AU - Kim, H-J AU - Kwon, C AU - Ramesh, R AU - Venkatesan, T AD - NSLS Brookhaven National Laboratory, Upton, New York 11973-5000, USA PY - 1998 SP - 794 EP - 796 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 392 IS - 6678 SN - 0028-0836, 0028-0836 KW - Toxicology Abstracts KW - Temperature effects KW - magnetism KW - Chromium KW - Thermodynamics KW - Temperature KW - Coexistence KW - Cadmium KW - coexistence KW - Manganese KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815534750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Direct+evidence+for+a+half-metallic+ferromagnet&rft.au=Park%2C+J-H%3BVescovo%2C+E%3BKim%2C+H-J%3BKwon%2C+C%3BRamesh%2C+R%3BVenkatesan%2C+T&rft.aulast=Park&rft.aufirst=J-H&rft.date=1998-04-03&rft.volume=392&rft.issue=6678&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2F33883 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Temperature effects; Thermodynamics; Chromium; Cadmium; Coexistence; Manganese; magnetism; Temperature; coexistence DO - http://dx.doi.org/10.1038/33883 ER - TY - JOUR T1 - A robust, inexpensive filter for blocking UVC radiation in broad-spectrum 'UVB' lamps. AN - 79963227; 9639912 AB - Accurate studies of the biological effects of UBV radiation require suitable laboratory sources. Lamps labeled as UVB sources often emit UVC radiation that contributes significantly to the levels of DNA damage. The UVC from an unfiltered UVB source produced more pyrimidine dimers in soybean DNA than a lamp filtered by a Pyrex dish that removes wavelengths of < 280 nm. Calculations based on action spectra and on the emission spectra of unfiltered lamps indicate that UVC contributes approximately 13%, 4% and approximately 1% of the total dimers induced in unshielded cells or DNA, alfalfa cotyledons, and human skin, respectively. Further, relative to a Pyrex dish-filtered lamp, an unfiltered lamp would produce approximately 7-, 2.4- or 2.8-fold more dimers in these three biological systems. We report here that a Pyrex dish provides an effective, stable, robust and inexpensive filter for reducing or excluding the contribution of UVC to damage induced by broad-spectrum 'UVB' lamps. JF - Journal of photochemistry and photobiology. B, Biology AU - Lepre, A M AU - Sutherland, J C AU - Trunk, J G AU - Sutherland, B M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 1998/04// PY - 1998 DA - April 1998 SP - 34 EP - 40 VL - 43 IS - 1 SN - 1011-1344, 1011-1344 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Ultraviolet Rays KW - Humans KW - Lighting KW - Glass KW - DNA -- radiation effects KW - Filtration -- instrumentation KW - Radiation Protection -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79963227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.atitle=A+robust%2C+inexpensive+filter+for+blocking+UVC+radiation+in+broad-spectrum+%27UVB%27+lamps.&rft.au=Lepre%2C+A+M%3BSutherland%2C+J+C%3BTrunk%2C+J+G%3BSutherland%2C+B+M&rft.aulast=Lepre&rft.aufirst=A&rft.date=1998-04-01&rft.volume=43&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.issn=10111344&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-08-03 N1 - Date created - 1998-08-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - An in situ study of the edingtonite dehydration processes from X-ray synchrotron powder diffraction AN - 52603899; 1998-032474 AB - The dehydration of edingtonite has been studied, using 61 consecutive powder patterns collected between 310 and 684 K, in steps of 6 K, at 5 min intervals; the structures were refined using the Rietveld method. At 310 K, the two water sites are both 3/4 occupied; between 310 and 400 K, the occupancy of the OW(1) site drops smoothly to 1/2 and, at the same time, the OW(2) occupancy starts to increase to reach a maximum of 88% at 450 K; a simple electrostatic model is suggested to explain this behaviour. Between 450 and 600 K, OW(2) shows a regular dehydration behaviour; the remaining water is then rapidly expelled as the water drops to 1 per Ba ion. Finally, as a consequence of an unstable Ba-O coordination, the edingtonite structure breaks down between 660 and 680 K. The framework responds to dehydration firstly by a chain rotation and later by intra-chain folding; both mechanisms can be related to the electrostatic and spatial needs of the Ba ion. JF - European Journal of Mineralogy AU - Stahl, Kenny AU - Hanson, Jonathan C Y1 - 1998/04// PY - 1998 DA - April 1998 SP - 221 EP - 228 PB - Schweizerbart'sche Verlagsbuchhandlung (Naegele u. Obermiller), Stuttgart VL - 10 IS - 2 SN - 0935-1221, 0935-1221 KW - synchrotron radiation KW - silicates KW - in situ KW - X-ray diffraction data KW - zeolite group KW - framework silicates KW - edingtonite KW - dehydration KW - Rietveld refinement KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52603899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Mineralogy&rft.atitle=An+in+situ+study+of+the+edingtonite+dehydration+processes+from+X-ray+synchrotron+powder+diffraction&rft.au=Stahl%2C+Kenny%3BHanson%2C+Jonathan+C&rft.aulast=Stahl&rft.aufirst=Kenny&rft.date=1998-04-01&rft.volume=10&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Mineralogy&rft.issn=09351221&rft_id=info:doi/10.1127%2Fejm%2F10%2F2%2F0221 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1998-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2016-04-14 N1 - SubjectsTermNotLitGenreText - dehydration; edingtonite; framework silicates; in situ; Rietveld refinement; silicates; synchrotron radiation; X-ray diffraction data; zeolite group DO - http://dx.doi.org/10.1127/ejm/10/2/0221 ER - TY - JOUR T1 - Selenium diffusion and reduction at the water-sediment boundary; micro-XANES spectroscopy of reactive transport AN - 52330125; 2000-052256 JF - Environmental Science & Technology, ES & T AU - Tokunaga, Tetsu K AU - Sutton, Stephen R AU - Bajt, Sasa AU - Nuessle, Patterson AU - Shea-McCarthy, Grace Y1 - 1998/04// PY - 1998 DA - April 1998 SP - 1092 EP - 1098 PB - American Chemical Society, Washington, DC VL - 32 IS - 8 SN - 0013-936X, 0013-936X KW - soils KW - concentration KW - sediment-water interface KW - selenium KW - pollutants KW - surface water KW - pollution KW - solubility KW - X-ray spectra KW - boundary conditions KW - chemical reactions KW - transport KW - sediments KW - spectra KW - reduction KW - trace elements KW - spectroscopy KW - diffusivity KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52330125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Selenium+diffusion+and+reduction+at+the+water-sediment+boundary%3B+micro-XANES+spectroscopy+of+reactive+transport&rft.au=Tokunaga%2C+Tetsu+K%3BSutton%2C+Stephen+R%3BBajt%2C+Sasa%3BNuessle%2C+Patterson%3BShea-McCarthy%2C+Grace&rft.aulast=Tokunaga&rft.aufirst=Tetsu&rft.date=1998-04-01&rft.volume=32&rft.issue=8&rft.spage=1092&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/ L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 48 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - boundary conditions; chemical reactions; concentration; diffusivity; pollutants; pollution; reduction; sediment-water interface; sediments; selenium; soils; solubility; spectra; spectroscopy; surface water; trace elements; transport; X-ray spectra ER - TY - JOUR T1 - Sorption of iodine on minerals investigated by X-ray absorption near edge structure (XANES) and (super 125) I tracer sorption experiments AN - 52590343; 1998-041378 AB - The sorption of I on minerals was examined by X-ray adsorption near edge structure (XANES) and high concentration chemical experiments as well as very low concentration (super 125) I tracer sorption experiments. A XANES method was used to determine the redox state of I in supernatant solutions and slurries of minerals. Pyrite reduced IO (super -) (sub 3) to I (sub 2) which was sorbed onto the pyrite surface, magnetite sorbed I (super -) from solution but not IO (super -) (sub 3) and biotite sorbed IO (super -) (sub 3) but not I (super -) . The presence of Fe (super 2+) in the sorbing phase appears to affect uptake but not necessarily oxidation state of I. The above results were corroborated with (super 125) I experiments. Other minerals also sorbed (super 125) I but at concentrations too low to be observed with XANES. Further experiments indicate that sorption of I (sub 2) onto mineral surfaces of pyrite inhibits the release of Fe to solution whilst S is oxidized to SO (super 2-) (sub 4) and released. JF - Applied Geochemistry AU - Fuhrmann, Mark AU - Bajt, Sasa AU - Schoonen, Martin A A Y1 - 1998/03// PY - 1998 DA - March 1998 SP - 127 EP - 141 PB - Pergamon, Oxford-New York-Beijing VL - 13 IS - 2 SN - 0883-2927, 0883-2927 KW - silicates KW - sorption KW - solutions KW - halogens KW - iron KW - XANES spectra KW - iodine KW - mica group KW - standard materials KW - tracers KW - oxides KW - spectra KW - geochemistry KW - pH KW - Eh KW - experimental studies KW - sulfate ion KW - X-ray spectra KW - ferrous iron KW - X-ray data KW - metals KW - biotite KW - sheet silicates KW - pyrite KW - sulfides KW - minerals KW - iodide ion KW - magnetite KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52590343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Geochemistry&rft.atitle=Sorption+of+iodine+on+minerals+investigated+by+X-ray+absorption+near+edge+structure+%28XANES%29+and+%28super+125%29+I+tracer+sorption+experiments&rft.au=Fuhrmann%2C+Mark%3BBajt%2C+Sasa%3BSchoonen%2C+Martin+A+A&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=1998-03-01&rft.volume=13&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Applied+Geochemistry&rft.issn=08832927&rft_id=info:doi/10.1016%2FS0883-2927%2897%2900068-1 L2 - http://www.sciencedirect.com/science/journal/08832927 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1998-01-01 N1 - Number of references - 59 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - biotite; Eh; experimental studies; ferrous iron; geochemistry; halogens; iodide ion; iodine; iron; magnetite; metals; mica group; minerals; oxides; pH; pyrite; sheet silicates; silicates; solutions; sorption; spectra; standard materials; sulfate ion; sulfides; tracers; X-ray data; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.1016/S0883-2927(97)00068-1 ER - TY - JOUR T1 - High resolution GPR at Brookhaven National Laboratory to delineate complex subsurface targets AN - 51276674; 2008-039970 AB - Detailed surface GPR measurements at Brookhaven National Laboratory (BNL) are shown to be very effective in defining the boundaries of complex waste pits. The data are most effectively interpreted using 3D views of data points that are obtained directly from the field data. Time slices of the 3D data sets can be used to determine the lateral boundaries of individual pits, while the 3D block views help to define the horizontal and vertical extent of the pits. The selection of parameters to produce a good 3D display of GPR data is shown to be an integral part of the interpretation process. JF - Journal of Environmental & Engineering Geophysics AU - Daniels, Jeffrey J AU - Brower, James AU - Baumgartner, Francois Y1 - 1998/03// PY - 1998 DA - March 1998 SP - 1 EP - 5 PB - Environmental and Engineering Geophysical Society, Englewood, CO VL - 3 IS - 1 SN - 1083-1363, 1083-1363 KW - United States KW - high-resolution methods KW - toxic materials KW - imagery KW - contaminant plumes KW - three-dimensional models KW - spatial data KW - Brookhaven National Laboratory KW - ground-penetrating radar KW - data acquisition KW - geophysical methods KW - data processing KW - waste disposal sites KW - radar methods KW - pollution KW - measurement KW - ground water KW - Suffolk County New York KW - water table KW - waste management KW - New York KW - interpretation KW - underground disposal KW - 20:Applied geophysics KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51276674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+%26+Engineering+Geophysics&rft.atitle=High+resolution+GPR+at+Brookhaven+National+Laboratory+to+delineate+complex+subsurface+targets&rft.au=Daniels%2C+Jeffrey+J%3BBrower%2C+James%3BBaumgartner%2C+Francois&rft.aulast=Daniels&rft.aufirst=Jeffrey&rft.date=1998-03-01&rft.volume=3&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+%26+Engineering+Geophysics&rft.issn=10831363&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 5 N1 - PubXState - CO N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Brookhaven National Laboratory; contaminant plumes; data acquisition; data processing; geophysical methods; ground water; ground-penetrating radar; high-resolution methods; imagery; interpretation; measurement; New York; pollution; radar methods; spatial data; Suffolk County New York; three-dimensional models; toxic materials; underground disposal; United States; waste disposal sites; waste management; water table ER - TY - JOUR T1 - Improvement of the prompt-gamma neutron activation facility at Brookhaven National Laboratory. AN - 79733234; 9509530 AB - The prompt-gamma neutron activation facility at Brookhaven National Laboratory was upgraded to improve both the precision and accuracy of its in vivo determinations of total body nitrogen. The upgrade, guided by Monte Carlo simulations, involved elongating and modifying the source collimator and its shielding, repositioning the system's two NaI(Tl) detectors, and improving the neutron and gamma shielding of these detectors. The new source collimator has a graphite reflector around the 238PuBe neutron source to enhance the low-energy region of the neutron spectrum incident on the patient. The gamma detectors have been relocated from positions close to the upward-emerging collimated neutron beam to positions close to and at the sides of the patient. These modifications substantially reduced spurious counts resulting from the capture of small-angle scattered neutrons in the NaI detectors. The pile-up background under the 10.8 MeV 14N(n, gamma)15N spectral peak has been reduced so that the nitrogen peak-to-background ratio has been increased by a factor of 2.8. The resulting reduction in the coefficient of variation of the total body nitrogen measurements from 3% to 2.2% has improved the statistical significance of the results possible for any given number of patient measurements. The new system also has a more uniform composite sensitivity. JF - Physics in medicine and biology AU - Dilmanian, F A AU - Lidofsky, L J AU - Stamatelatos, I AU - Kamen, Y AU - Yasumura, S AU - Vartsky, D AU - Pierson, R N AU - Weber, D A AU - Moore, R I AU - Ma, R AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 339 EP - 349 VL - 43 IS - 2 SN - 0031-9155, 0031-9155 KW - Nitrogen Isotopes KW - 0 KW - Nitrogen KW - N762921K75 KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Radiation Protection KW - Humans KW - Monte Carlo Method KW - Nuclear Reactors KW - Models, Theoretical KW - Phantoms, Imaging KW - Neutrons KW - Gamma Rays KW - Nitrogen -- analysis KW - Neutron Activation Analysis -- methods KW - Neutron Activation Analysis -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79733234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+in+medicine+and+biology&rft.atitle=Improvement+of+the+prompt-gamma+neutron+activation+facility+at+Brookhaven+National+Laboratory.&rft.au=Dilmanian%2C+F+A%3BLidofsky%2C+L+J%3BStamatelatos%2C+I%3BKamen%2C+Y%3BYasumura%2C+S%3BVartsky%2C+D%3BPierson%2C+R+N%3BWeber%2C+D+A%3BMoore%2C+R+I%3BMa%2C+R&rft.aulast=Dilmanian&rft.aufirst=F&rft.date=1998-02-01&rft.volume=43&rft.issue=2&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Physics+in+medicine+and+biology&rft.issn=00319155&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-04-14 N1 - Date created - 1998-04-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Enhanced sensitivity to benzodiazepines in active cocaine-abusing subjects: a PET study. AN - 79685744; 9464198 AB - OBJECTIVEBecause cocaine enhances dopamine brain activity and dopamine signals are transferred through gamma-aminobutyric acid pathways, the authors hypothesized GABA-ergic disruption in cocaine-abusing subjects. This study tests this hypothesis.METHODGABA brain function was assessed indirectly by measuring the brain metabolic responses to lorazepam, a drug that facilitates GABA neurotransmission. Thirteen current cocaine-abusing subjects and 14 comparison subjects were scanned twice with positron emission tomography and [18F]fluorodeoxyglucose; the first scan was obtained after placebo administration and the second after lorazepam administration (30 micrograms/kg).RESULTSDespite significantly higher plasma lorazepam concentrations in comparison subjects than in cocaine-abusing subjects, lorazepam-induced decrements in whole brain metabolism were significantly greater in cocaine-abusing (mean = 21%, SD = 13%) than in comparison (mean = 13%, SD = 7%) subjects. These differences were largest in striatum, thalamus, and parietal cortex. Lorazepam-induced sleepiness in cocaine-abusing subjects was intense and was significantly greater than in comparison subjects, and it was correlated with lorazepam-induced changes in thalamic metabolism. Whereas regional metabolic measures during placebo administration were significantly higher in cocaine-abusing subjects than in comparison subjects, the measures during lorazepam administration were equivalent for both groups.CONCLUSIONSThe enhanced sensitivity to lorazepam in cocaine-abusing subjects suggests disruption of GABA pathways that may reflect, in part, cocaine withdrawal. The intense sleepiness induced by lorazepam in some of the abusers, despite their significantly lower plasma concentrations, should alert clinicians of the potential toxicity from accentuated responses to sedative hypnotics in active cocaine-abusing subjects. JF - The American journal of psychiatry AU - Volkow, N D AU - Wang, G J AU - Fowler, J S AU - Hitzemann, R AU - Gatley, S J AU - Dewey, S S AU - Pappas, N AD - Medical Department, Brookhaven National Laboratory, NY 11973, USA. volkow@bnl.gov Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 200 EP - 206 VL - 155 IS - 2 SN - 0002-953X, 0002-953X KW - Receptors, GABA KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Glucose KW - IY9XDZ35W2 KW - Lorazepam KW - O26FZP769L KW - Abridged Index Medicus KW - Index Medicus KW - Substance Withdrawal Syndrome -- etiology KW - Sleep -- drug effects KW - Humans KW - Adult KW - Male KW - Female KW - Receptors, GABA -- drug effects KW - Lorazepam -- blood KW - Glucose -- metabolism KW - Brain -- drug effects KW - Tomography, Emission-Computed KW - Cocaine-Related Disorders -- blood KW - Brain -- metabolism KW - Cocaine-Related Disorders -- metabolism KW - Brain -- diagnostic imaging KW - Lorazepam -- pharmacology KW - Lorazepam -- adverse effects KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79685744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Enhanced+sensitivity+to+benzodiazepines+in+active+cocaine-abusing+subjects%3A+a+PET+study.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BFowler%2C+J+S%3BHitzemann%2C+R%3BGatley%2C+S+J%3BDewey%2C+S+S%3BPappas%2C+N&rft.aulast=Volkow&rft.aufirst=N&rft.date=1998-02-01&rft.volume=155&rft.issue=2&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-02-19 N1 - Date created - 1998-02-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Surface charge development on transition metal sulfides; an electrokinetic study AN - 52607150; 1998-031713 AB - The results of a study comparing the charge development of different metal sulphides as a function of pH and dissolved metal activity, using electrophoresis, are presented. The chosen monosulphides and disulphides (including arsenopyrite) include most common metal sulphides. Metal sulphides in aqueous solutions with low metal activity have estimated pH (sub i.e.p.) (isoelectric points) values of 0.6-3.3, with most values << pH 2.0. Above pH (sub i.e.p.) the zeta potentials are negative. The crystal structure and stoichiometry play, it is suggested, a minor role in the development of the zeta potential vs pH curves, and the similarities of these curves for systems without added potential determining ions suggest that the surface chemistry is deominated by the S surface functional groups. The results confirm the predominance of the S atom on metal sulphide surfaces. The prevention of mineral oxidation prior to measurement is crucial for reproducible and comparable data. Multiple types of surface functional groups occur on metal sulphide surfaces. JF - Geochimica et Cosmochimica Acta AU - Bebie, Joakim AU - Schoonen, Martin A A AU - Fuhrmann, Mark AU - Strongin, Daniel R Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 633 EP - 642 PB - Pergamon, Oxford VL - 62 IS - 4 SN - 0016-7037, 0016-7037 KW - surface properties KW - electrical properties KW - transition metals KW - metals KW - electrolytes KW - sulfides KW - solution KW - kinetics KW - geochemistry KW - pH KW - charge development KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52607150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Surface+charge+development+on+transition+metal+sulfides%3B+an+electrokinetic+study&rft.au=Bebie%2C+Joakim%3BSchoonen%2C+Martin+A+A%3BFuhrmann%2C+Mark%3BStrongin%2C+Daniel+R&rft.aulast=Bebie&rft.aufirst=Joakim&rft.date=1998-02-01&rft.volume=62&rft.issue=4&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2FS0016-7037%2898%2900058-1 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1998-01-01 N1 - Number of references - 37 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - charge development; electrical properties; electrolytes; geochemistry; kinetics; metals; pH; solution; sulfides; surface properties; transition metals DO - http://dx.doi.org/10.1016/S0016-7037(98)00058-1 ER - TY - JOUR T1 - Biodegradation and bioremediation; phytoremediation of a radiocesium-contaminated soil; evaluation of cesium-137 bioaccumulation in the shoots of three plant species AN - 52102064; 2002-041855 AB - A field study was conducted to investigate the potential of three plant species for phytoremediation of a (super 137) Cs-contaminated site. Approximately 40-fold more (super 137) Cs was removed from the contaminated soil in shoots of red root pigweed (Amaranthus retroflexus L.) than in those of Indian mustard [Brassica juncea (L.) Czern] and tepary bean (Phaseolus acutifolius A. Gray). The greater potential for (super 137) Cs removal from the soil by A. retroflexus was associated with both high concentration of (super 137) Cs in shoots and high shoot biomass production. Approximately 3% of the total (super 137) Cs was removed from the top 15 cm of the soil (which contained most of the soil radiocesium) in shoots of 3-mo-old A. retroflexus plants. Soil leaching tests conducted with 0.1 and 0.5 M NH (sub 4) NO (sub 3) solutions eluted as much as 15 and 19%, respectively, of the soil (super 137) Cs. Addition of NH (sub 4) NO (sub 3) to the soil, however, had no positive effect on (super 137) Cs accumulation in shoots in any of the species investigated. It is proposed that either NH (sub 4) NO (sub 3) solution quickly percolated through the soil before interacting at specific (super 137) Cs binding sites or radiocesium mobilized by NH (sub 4) NO (sub 3) application moved below the rhizosphere, becoming unavailable for root uptake. Further research is required to optimize the phytotransfer of the NH (sub 4) NO (sub 3) -mobilized (super 137) Cs. With two croppings of A. retroflexus per year and a sustained rate of extraction, phytoremediation of this (super 137) Cs-contaminated soil appears feasible in <15 yr. JF - Journal of Environmental Quality AU - Lasat, Mitch M AU - Fuhrmann, Mark AU - Ebbs, Stephen D AU - Cornish, Jay E AU - Kochian, Leon V Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 165 EP - 169 PB - American Society of Agronomy, [and] Crop Science Society of America, [and] Soil Science Society of America, Madison, WI VL - 27 IS - 1 SN - 0047-2425, 0047-2425 KW - soils KW - biodegradation KW - Plantae KW - isotopes KW - pollutants KW - alkali metals KW - pollution KW - bioremediation KW - remediation KW - bioaccumulation KW - radioactive isotopes KW - Cs-137 KW - cesium KW - metals KW - phytoremediation KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52102064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Quality&rft.atitle=Biodegradation+and+bioremediation%3B+phytoremediation+of+a+radiocesium-contaminated+soil%3B+evaluation+of+cesium-137+bioaccumulation+in+the+shoots+of+three+plant+species&rft.au=Lasat%2C+Mitch+M%3BFuhrmann%2C+Mark%3BEbbs%2C+Stephen+D%3BCornish%2C+Jay+E%3BKochian%2C+Leon+V&rft.aulast=Lasat&rft.aufirst=Mitch&rft.date=1998-02-01&rft.volume=27&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Quality&rft.issn=00472425&rft_id=info:doi/ L2 - http://jeq.scijournals.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 24 N1 - PubXState - WI N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - JEVQAA N1 - SubjectsTermNotLitGenreText - alkali metals; bioaccumulation; biodegradation; bioremediation; cesium; Cs-137; isotopes; metals; phytoremediation; Plantae; pollutants; pollution; radioactive isotopes; remediation; soils ER - TY - JOUR T1 - PET imaging studies in drug abuse. AN - 79988697; 9656971 AB - UNLABELLEDIn spite of the massive public health problem associated with drug abuse, effective treatments remain elusive. This is due in part to a relatively poor understanding of the neurochemical changes which drugs of abuse produce in the human brain and the relationship of these changes to the behavioral and addictive properties of drugs. With the development of modern imaging methods and a variety of labeled drugs and radiotracers, it has now become possible to track many aspects of drug pharmacokinetics and pharmacodynamics directly in the human brain and to relate these parameters to the behavioral and toxic properties of drugs.REVIEWIn this article, we will highlight some examples of the use of Positron Emission Tomography to measure drug pharmacokinetics and pharmacodynamics and their relationship to addiction and to toxicity. JF - Journal of toxicology. Clinical toxicology AU - Fowler, J S AU - Volkow, N D AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. fowler@bnl.gov Y1 - 1998 PY - 1998 DA - 1998 SP - 163 EP - 174 VL - 36 IS - 3 SN - 0731-3810, 0731-3810 KW - Street Drugs KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Street Drugs -- pharmacokinetics KW - Street Drugs -- pharmacology KW - Substance Abuse Detection KW - Humans KW - Brain -- drug effects KW - Tomography, Emission-Computed KW - Brain -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79988697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology.+Clinical+toxicology&rft.atitle=PET+imaging+studies+in+drug+abuse.&rft.au=Fowler%2C+J+S%3BVolkow%2C+N+D&rft.aulast=Fowler&rft.aufirst=J&rft.date=1998-01-01&rft.volume=36&rft.issue=3&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology.+Clinical+toxicology&rft.issn=07313810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-22 N1 - Date created - 1998-07-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Treatment of metastatic bone pain with tin-117m Stannic diethylenetriaminepentaacetic acid: a phase I/II clinical study. AN - 79747459; 9516953 AB - The physical characteristics of Sn-117m combined with the biodistribution of the compound tin-117m (Stannic, 4+) diethylenetriaminepentaacetic acid (Sn-117m DTPA) suggest that it should be an excellent agent for the palliation of pain from bony metastases. Prior work has established the dosimetry and the safety for the material in human beings. The presence of low-energy conversion electrons should result in the relative sparing of the bone marrow while delivering a high radiation dose to sites of bony metastatic disease. Forty-seven patients with painful bone metastases from various malignancies were treated with Sn-117m DTPA. The patients were assigned to five different dose levels ranging from 2.64 to 10.58 MBq (71-286 microCi) per kg of body weight. Follow-up included review of pain diaries, performance scores, analgesic requirements, blood chemistries, and hematological assessment. Three patients received a second treatment. There was an overall response rate for relief of pain of 75% (range, 60-83%) in the 40 treatments that could be evaluated. No correlation was apparent in this limited series between response rate and the five dose levels used. The relief was complete in 12 patients (30%). The time to onset of pain relief was 19 +/- 15 days with doses < or = 5.29 MBq/kg and 5 +/- 3 days with doses > or = 6.61 MBq/kg. Myelotoxicity was minimal, with only one patient having a marginal grade 3 WBC toxicity. On the basis of our data, Sn-117m DTPA should be an effective and safe radiopharmaceutical for palliation of painful bony metastases. A large-scale trial is warranted to evaluate it in comparison to other similar agents. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Srivastava, S C AU - Atkins, H L AU - Krishnamurthy, G T AU - Zanzi, I AU - Silberstein, E B AU - Meinken, G AU - Mausner, L F AU - Swailem, F AU - D'Alessandro, T AU - Cabahug, C J AU - Lau, Y AU - Park, T AU - Madajewicz, S AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 1998/01// PY - 1998 DA - January 1998 SP - 61 EP - 68 VL - 4 IS - 1 SN - 1078-0432, 1078-0432 KW - Tin Radioisotopes KW - 0 KW - Index Medicus KW - Humans KW - Palliative Care KW - Bone Marrow -- radiation effects KW - Male KW - Female KW - Bone Neoplasms -- physiopathology KW - Pain, Intractable -- radiotherapy KW - Bone Neoplasms -- radiotherapy KW - Tin Radioisotopes -- therapeutic use KW - Bone Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79747459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Treatment+of+metastatic+bone+pain+with+tin-117m+Stannic+diethylenetriaminepentaacetic+acid%3A+a+phase+I%2FII+clinical+study.&rft.au=Srivastava%2C+S+C%3BAtkins%2C+H+L%3BKrishnamurthy%2C+G+T%3BZanzi%2C+I%3BSilberstein%2C+E+B%3BMeinken%2C+G%3BMausner%2C+L+F%3BSwailem%2C+F%3BD%27Alessandro%2C+T%3BCabahug%2C+C+J%3BLau%2C+Y%3BPark%2C+T%3BMadajewicz%2C+S&rft.aulast=Srivastava&rft.aufirst=S&rft.date=1998-01-01&rft.volume=4&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-04-09 N1 - Date created - 1998-04-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - BOOK T1 - Characterization of geological materials using ion and photon beams AN - 52537864; 1998-074324 JF - Nuclear methods in mineralogy and geology; techniques and applications AU - Torok, S B AU - Jones, K W AU - Tuniz, C A2 - Vertes, Attila A2 - Nagy, Sandor A2 - Suvegh, Karoly Y1 - 1998 PY - 1998 DA - 1998 PB - Plenum Press, New York KW - minor elements KW - geophysical methods KW - techniques KW - mass spectroscopy KW - synchrotron radiation KW - brightness KW - major elements KW - sensitivity analysis KW - electromagnetic methods KW - accelerator mass spectroscopy KW - chemical composition KW - spectroscopy KW - geochemistry KW - accuracy KW - instruments KW - 20:Applied geophysics KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52537864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Torok%2C+S+B%3BJones%2C+K+W%3BTuniz%2C+C&rft.aulast=Torok&rft.aufirst=S&rft.date=1998-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Characterization+of+geological+materials+using+ion+and+photon+beams&rft.title=Characterization+of+geological+materials+using+ion+and+photon+beams&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 144 N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - XAFS study of local structure in dilute carbonate solid solutions AN - 52512419; 1999-017295 AB - Rhombohedral carbonates are notable for exhibiting widely different solid solution behaviors depending to a large degree on cation size. Until recently, understanding of the atomic scale structure of solid solutions has been limited. We have analyzed divalent Co, Zn, Pb, and Ba XAFS spectra of synthetic and natural trace-element containing calcite samples to determine the local distortion and relaxation around these impurities substituting for Ca. The octahedral coordination found for Ba is noteworthy because of its large size (35% larger than host Ca) and the fact that it rarely exists as a major constituent with such a low coordination number. Multishell fits of XAFS spectra show a nearly complete contraction of the structure around divalent Co and Zn. The Co-O and Zn-O first-shell distances are only slightly longer than in CoCO (sub 3) and ZnCO (sub 3) , with a site compliance of 80-90%. The dilation around the large divalent Pb and Ba ions in calcite also shows a high site compliance. More distant C, O, and Ca shells for all samples show displacements relative to those in pure calcite that decrease rapidly with radial distance, revealing that the relaxation is mostly confined within roughly 6 7 Aa around the impurity, although the dilation around Ba may have a slightly greater radial extent. Comparison of these observations with XAFS studies of other solid solutions suggests that the compliance of the octahedral site in calcite is larger than for the cation site in the rocksalt structure, where significant variation of first-shell interatomic distances with composition has been found. The high compliance for the metal site in calcite may reflect the corner-sharing topology of the structure, and may also be the reason that calcite shows such a wide range of isovalent substitutions in nature. The findings provide a direct indication of the localized strain associated with a dilute substitutional solid solution of calcite and may be applicable to solutions involving other rhombohedral carbonates. JF - Abstracts with Programs - Geological Society of America AU - Reeder, Richard J AU - Lamble, Geraldine M AU - Northrup, Paul A AU - Anonymous Y1 - 1998 PY - 1998 DA - 1998 SP - 153 PB - Geological Society of America (GSA), Boulder, CO VL - 30 IS - 7 SN - 0016-7592, 0016-7592 KW - strain KW - solutions KW - coordination KW - cations KW - substitution KW - crystal structure KW - trace elements KW - solid solution KW - crystal chemistry KW - carbonates KW - calcite KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52512419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=XAFS+study+of+local+structure+in+dilute+carbonate+solid+solutions&rft.au=Reeder%2C+Richard+J%3BLamble%2C+Geraldine+M%3BNorthrup%2C+Paul+A%3BAnonymous&rft.aulast=Reeder&rft.aufirst=Richard&rft.date=1998-01-01&rft.volume=30&rft.issue=7&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1998 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 1999-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - calcite; carbonates; cations; coordination; crystal chemistry; crystal structure; solid solution; solutions; strain; substitution; trace elements ER - TY - JOUR T1 - Cathodoluminescence as a probe of heterogeneous reactivity at the mineral-water interface AN - 52454764; 1999-050507 JF - Abstracts with Programs - Geological Society of America AU - Rakovan, John AU - Shea, Grace AU - Anonymous Y1 - 1998 PY - 1998 DA - 1998 SP - 59 PB - Geological Society of America (GSA), Boulder, CO VL - 30 IS - 7 SN - 0016-7592, 0016-7592 KW - reactivity KW - X-ray fluorescence spectra KW - mineral-water interface KW - mechanism KW - crystal growth KW - spectra KW - adsorption KW - trace elements KW - heterogeneity KW - zoning KW - cathodoluminescence KW - 01A:General mineralogy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52454764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Cathodoluminescence+as+a+probe+of+heterogeneous+reactivity+at+the+mineral-water+interface&rft.au=Rakovan%2C+John%3BShea%2C+Grace%3BAnonymous&rft.aulast=Rakovan&rft.aufirst=John&rft.date=1998-01-01&rft.volume=30&rft.issue=7&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1998 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 1999-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - adsorption; cathodoluminescence; crystal growth; heterogeneity; mechanism; mineral-water interface; reactivity; spectra; trace elements; X-ray fluorescence spectra; zoning ER - TY - JOUR T1 - The role of the Indian Ocean as a sink for anthropogenic carbon dioxide AN - 50445045; 2009-042793 JF - Eos, Transactions, American Geophysical Union AU - Sabine, C L AU - Dickson, A G AU - Goyet, C AU - Guenther, P AU - Johnson, K M AU - Key, R M AU - Millero, F J AU - Sarmiento, J L AU - Wallace, D R W AU - Winn, C D AU - Anonymous Y1 - 1998/01// PY - 1998 DA - January 1998 SP - 55 PB - American Geophysical Union, Washington, DC VL - 79 IS - 1, Suppl. SN - 0096-3941, 0096-3941 KW - currents KW - human activity KW - sinks KW - ocean currents KW - World Ocean Circulation Experiment KW - carbon dioxide KW - ocean basins KW - Indian Ocean KW - transport KW - deposition KW - surveys KW - alkalinity KW - world ocean KW - South Equatorial Current KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50445045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=The+role+of+the+Indian+Ocean+as+a+sink+for+anthropogenic+carbon+dioxide&rft.au=Sabine%2C+C+L%3BDickson%2C+A+G%3BGoyet%2C+C%3BGuenther%2C+P%3BJohnson%2C+K+M%3BKey%2C+R+M%3BMillero%2C+F+J%3BSarmiento%2C+J+L%3BWallace%2C+D+R+W%3BWinn%2C+C+D%3BAnonymous&rft.aulast=Sabine&rft.aufirst=C&rft.date=1998-01-01&rft.volume=79&rft.issue=1%2C+Suppl.&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union and American Society of Limnology and Oceanography, 1998 ocean sciences meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - alkalinity; carbon dioxide; currents; deposition; human activity; Indian Ocean; ocean basins; ocean currents; sinks; South Equatorial Current; surveys; transport; world ocean; World Ocean Circulation Experiment ER - TY - JOUR T1 - Physiological stress and cell death in marine phytoplankton: Induction of proteases in response to nitrogen or light limitation AN - 1808728012; PQ0003341176 AB - The physiological processes of natural phytoplankton mortality due to environmental stress (vs. that caused by sedimentation and predation) are poorly understood. Cell survival was examined in batch cultures of the diatom Thalassiosira weissflogii and the chlorophyte Dunaliella tertiolecta during deprivation of fixed nitrogen or light. Despite severe impairment of photosynthetic efficiencies, both species remained viable during 2 weeks of N starvation. Under N stress, a specific protease was induced in the diatom, overall activity of proteases doubled, and there was gradual, selective loss of certain proteins, especially ribulose 1,5-bisphosphate carboxylase/oxygenase. Light-deprived diatoms were virtually unaffected, but the chlorophyte underwent catastrophic cell death after about 6 d of darkness. Cell death coincided with a large increase in protease activity and the induction of a specific protease. Although we cannot completely rule out roles for viruses or bacteria in the losses of cells, the consistent timing, the unique response to stress, and the coincident expression of a specific protease strongly suggest that the process is a form of autocatalyzed cell death, such as apoptosis. While of uncertain adaptive significance, phytoplankton cell death may have implications for species succession and cycling of organic matter in aquatic ecosysterns. JF - Limnology and Oceanography AU - Berges, John A AU - Falkowski, Paul G AD - Oceanographic and Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1998/01// PY - 1998 DA - January 1998 SP - 129 EP - 135 PB - Association for the Sciences of Limnology and Oceanography VL - 43 IS - 1 SN - 0024-3590, 0024-3590 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Cell survival KW - Chlorophylls KW - Predation KW - Viruses KW - Phytoplankton KW - Succession KW - Batch culture KW - Proteinase KW - Sedimentation KW - Starvation KW - Stress KW - Oceanography KW - Adaptiveness KW - Thalassiosira weissflogii KW - Algae (diatoms) KW - Periphyton KW - Oxygenase KW - Nitrogen KW - Apoptosis KW - Diatoms KW - Survival KW - Dunaliella tertiolecta KW - Environmental stress KW - Marine KW - Bacteria KW - Mortality KW - Plankton surveys KW - Organic matter KW - Light effects KW - Cultures KW - Mortality causes KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q1 08442:Population dynamics KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808728012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Physiological+stress+and+cell+death+in+marine+phytoplankton%3A+Induction+of+proteases+in+response+to+nitrogen+or+light+limitation&rft.au=Berges%2C+John+A%3BFalkowski%2C+Paul+G&rft.aulast=Berges&rft.aufirst=John&rft.date=1998-01-01&rft.volume=43&rft.issue=1&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1998.43.1.0129 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Starvation; Plankton surveys; Chlorophylls; Organic matter; Viruses; Survival; Phytoplankton; Periphyton; Sedimentation; Mortality causes; Batch culture; Nitrogen; Cell survival; Mortality; Apoptosis; Predation; Diatoms; Adaptiveness; Succession; Light effects; Proteinase; Environmental stress; Oxygenase; Algae (diatoms); Bacteria; Cultures; Stress; Oceanography; Dunaliella tertiolecta; Thalassiosira weissflogii; Marine DO - http://dx.doi.org/10.4319/lo.1998.43.1.0129 ER - TY - JOUR T1 - Occurrence and environmental significance of long-chain alkenones in Tibetan Zabuye Salt Lake, S.W. China AN - 16549289; 4387979 AB - Long-chain alkenones, a group of sensitive organic molecular indicators of water temperature, have been rather extensively studied in marine environments. However they have never been systematically examined in lacustrine environments, despite reports of their occurrence in lake sediments. Here, we report on a recent study of long-chain alkenones in a sedimentary core from a high altitude ( similar to 5400 m) salt lake, Zabuye Salt Lake (ZSL), Tibet. This is a critical location for global climate studies, especially of the atmospheric circulation of the North Hemisphere. C sub(37)-C sub(39) methyl and/or ethyl alkenones, usually dominated by components with tetra- and tri-double bounds, are commonly the major components of the polar fraction of the extracted organic matter from most sections. Down-core (vertical) variation of alkenone indices, the measure of molecular unsaturation, is compared primarily with other environmental signals, including lithology, elemental and mineral compositions, and stable carbon isotopes of hydrocarbon biomarkers of this core. Down-core profiles of alkenone climatic indices (U super(k) sub(37) and U super(k) sub(38)) suggest ZSL had two warm periods, one during similar to 20 - 30 ka ( similar to Jabula Interglacial Optimum) and another at 8 -5 ka (Middle Holocene Optimum), and a severe cold period from similar to 18 -11 ka (Last Glacial Maximum). The proposed warmer intervals are generally characterized by higher contents of carbonate, organic carbon, alkenones and heavier delta super(13)C values of n-alkanes. JF - International Journal of Salt Lake Research AU - Wang, Ruiliang AU - Zheng, Mianping AD - S&EP Division, Building 535A, Brookhaven National Laboratory, Upton, NY 11973, USA, rlwangnl.gov Y1 - 1998 PY - 1998 DA - 1998 SP - 281 EP - 302 VL - 6 IS - 4 SN - 1037-0544, 1037-0544 KW - China, Tibet, Zabuye Salt L. KW - Tibet, Zabuye Salt L. KW - alkenones KW - long-chain alkenones KW - Pollution Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Organic carbon KW - Salt lakes KW - Lake sediments KW - Holocene KW - Mountains KW - Salinity KW - Lakes KW - Palaeotemperature KW - China, People's Rep., Xizang, Zabuye L. KW - Hydrocarbons KW - Organic matter KW - Climates KW - Climate KW - Temperature KW - Stratigraphy KW - Water temperature KW - Sediment composition KW - Chemical analysis KW - Q2 09148:Palaeo-studies KW - P 1000:MARINE POLLUTION KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16549289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Salt+Lake+Research&rft.atitle=Occurrence+and+environmental+significance+of+long-chain+alkenones+in+Tibetan+Zabuye+Salt+Lake%2C+S.W.+China&rft.au=Wang%2C+Ruiliang%3BZheng%2C+Mianping&rft.aulast=Wang&rft.aufirst=Ruiliang&rft.date=1998-01-01&rft.volume=6&rft.issue=4&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Salt+Lake+Research&rft.issn=10370544&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Palaeotemperature; Hydrocarbons; Organic matter; Climate; Organic carbon; Stratigraphy; Temperature; Salt lakes; Water temperature; Holocene; Mountains; Lakes; Salinity; Sediment composition; Chemical analysis; Climates; Lake sediments; China, People's Rep., Xizang, Zabuye L. ER - TY - JOUR T1 - Neuropharmacological actions of cigarette smoke: Brain monoamine oxidase B (MAO B) inhibition AN - 16526581; 4372167 AB - We measured the concentration of brain monoamine oxidase B (MAO B; EC 1.4.3.4) in 8 smokers and compared it with that in 8 non-smokers and in 4 former smokers using positron emission tomography (PET) and deuterium substituted [ super(11)C]L-deprenyl ([ super(11)C]L-deprenyl-D2) as a radiotracer for MAO B. Smokers had significantly lower brain MAO B than non-smokers as measured by the model term lambda k sub(3) which is a function of MAO B activity. Reductions were observed in all brain regions. Low brain MAO B in the cigarette smoker appears to be a pharmacological rather than a genetic effect since former smokers did not differ from non-smokers. Brain MAO B inhibition by cigarette smoke is of relevance in light of the inverse association between smoking and Parkinson's disease and a high prevalence of smoking in psychiatric disorders and in substance abuse. Though nicotine is at the core of the neuropharmacological actions of tobacco smoke, MAO B inhibition may also be an important variable in understanding and treating tobacco smoke addiction. JF - Journal of Addictive Diseases AU - Fowler, J S AU - Volkow, N D AU - Wang, G-J AU - Pappas, N AU - Logan, J AU - MacGregor, R AU - Alexoff, D AU - Wolf AU - Warner, D AU - Cilento, R AU - Zezulkova, I AD - Department of Chemistry and Medicine, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 1998 PY - 1998 DA - 1998 SP - 23 EP - 34 VL - 17 IS - 1 SN - 1055-0887, 1055-0887 KW - amine oxidase (flavin-containing) B KW - man KW - monoamine oxidase B KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16526581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictive+Diseases&rft.atitle=Neuropharmacological+actions+of+cigarette+smoke%3A+Brain+monoamine+oxidase+B+%28MAO+B%29+inhibition&rft.au=Fowler%2C+J+S%3BVolkow%2C+N+D%3BWang%2C+G-J%3BPappas%2C+N%3BLogan%2C+J%3BMacGregor%2C+R%3BAlexoff%2C+D%3BWolf%3BWarner%2C+D%3BCilento%2C+R%3BZezulkova%2C+I&rft.aulast=Fowler&rft.aufirst=J&rft.date=1998-01-01&rft.volume=17&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictive+Diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Imaging the brain marijuana receptor: Development of a radioligand that binds to cannabinoid CB1 receptors in vivo AN - 16339059; 4263131 AB - The major active ingredient of marijuana, (-)- Delta super(9)-tetrahydrocannabinol, exerts its psychoactive effects via binding to cannabinoid CB1 receptors, which are widely distributed in the brain. Radionuclide imaging of CB1 receptors in living human subjects would help explore the presently unknown physiological roles of this receptor system, as well as the neurochemical consequences of marijuana dependence. Currently available cannabinoid receptor radioligands are exceedingly lipophilic and unsuitable for in vivo use. We report the development of a novel radioligand, [ super(123)I]AM281 {N-(morpholin-4-yl)-5-(4-[ super(123)I]iodophenyl)-1-(2,4-dichloropheny l)-4-methyl-1H-pyrazole-3-carboxamide}, that is structurally related to the CB1-selective antagonist SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-me t hyl-1H-pyrazole-3-carboxamide]. Baboon single photon emission computed tomography studies, mouse brain dissection studies, and ex vivo autoradiography in rat brain demonstrated rapid passage of [ super(123)I]AM281 into the brain after intravenous injection, appropriate regional brain specificity of binding, and reduction of binding after treatment with SR141716A. AM281 has an affinity in the low nanomolar range for cerebellar binding sites labeled with [ super(3)H]SR141716A in vitro, and binding of [ super(123)I]AM281 is inhibited by several structurally distinct cannabinoid receptor ligands. We conclude that [ super(123)I]AM281 has appropriate properties for in vivo studies of cannabinoid CB1 receptors and is suitable for imaging these receptors in the living human brain. JF - Journal of Neurochemistry AU - Gatley, S J AU - Lan, Ruoxi AU - Volkow, N D AU - Pappas, N AU - King, P AU - Wong, C T AU - Gifford, AN AU - Pyatt, B AU - Dewey, S L AU - Makriyannis, A AD - Medical Department, 490 Bell Avenue, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 1998/01// PY - 1998 DA - Jan 1998 SP - 417 EP - 423 VL - 70 IS - 1 SN - 0022-3042, 0022-3042 KW - CB1 protein KW - Mammalia KW - SPECT KW - SR141716A KW - [ super(123)I]AM281 KW - Delta super(9)-THC KW - Delta super(9)-tetrahydrocannabinol KW - baboons KW - brain KW - brain mapping KW - cannabinoid CB1 receptors KW - cannabinoid receptors KW - in vivo KW - marijuana KW - neuroimaging KW - radioligands KW - single photon emission computed tomography KW - tetrahydrocannabinol KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - N3 11021:Neuroimaging techniques KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16339059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Imaging+the+brain+marijuana+receptor%3A+Development+of+a+radioligand+that+binds+to+cannabinoid+CB1+receptors+in+vivo&rft.au=Gatley%2C+S+J%3BLan%2C+Ruoxi%3BVolkow%2C+N+D%3BPappas%2C+N%3BKing%2C+P%3BWong%2C+C+T%3BGifford%2C+AN%3BPyatt%2C+B%3BDewey%2C+S+L%3BMakriyannis%2C+A&rft.aulast=Gatley&rft.aufirst=S&rft.date=1998-01-01&rft.volume=70&rft.issue=1&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Synchrotron X-ray computed microtomography studies of vesiculated basaltic rocks AN - 1015460781; 2012-045812 JF - Abstracts - International Volcanological Congress AU - Song, S R AU - Jones, K W AU - Lindquist, W B AU - Dowd, B A AU - Sahagian, D L AU - Anonymous Y1 - 1998 PY - 1998 DA - 1998 EP - unpaginated PB - International Association of Volcanology and Chemistry of the Earth's Interior (IAVCEI), [location varies] VL - 1998 KW - X-ray data KW - volcanic rocks KW - igneous rocks KW - basalts KW - synchrotrons KW - computed tomography data KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1015460781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+-+International+Volcanological+Congress&rft.atitle=Synchrotron+X-ray+computed+microtomography+studies+of+vesiculated+basaltic+rocks&rft.au=Song%2C+S+R%3BJones%2C+K+W%3BLindquist%2C+W+B%3BDowd%2C+B+A%3BSahagian%2C+D+L%3BAnonymous&rft.aulast=Song&rft.aufirst=S&rft.date=1998-01-01&rft.volume=1998&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstracts+-+International+Volcanological+Congress&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Magmatic diversity; volcanoes and their roots N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2012-01-01 N1 - Last updated - 2014-12-15 N1 - CODEN - #05692 N1 - SubjectsTermNotLitGenreText - basalts; computed tomography data; igneous rocks; synchrotrons; volcanic rocks; X-ray data ER - TY - JOUR T1 - Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET. AN - 79421758; 9372557 AB - The concentration (Bmax) of the dopamine transporter (DAT) and the maximum and effective occupancies by cocaine doses of 0.1 mg/kg or 0.05 mg/kg were measured in the striatum of cocaine abusers (n = 12) by using [11C]cocaine as a radiotracer for the DAT and positron emission tomography (PET). Two methods based on a three-compartment model with one binding site (the nonlinear least squares (NLSQ) and the Farde pseudoequilibrium method) were used to estimate Bmax. Effective occupancies and maximum occupancies were calculated from the distribution volume ratios (DVR) and a three-compartment model, respectively. The NLSQ and Farde methods gave similar values of Bmax (average, 650 +/- 350 pmol/ml and 776 +/- 400 pmol/ml, respectively), but the individual estimates of Bmax were found to be very sensitive to small variations in other model parameters and were not correlated with the parameter Bmax/Kd (r = .07). The average maximum (and effective) occupancies were found to be 67% (50%) and 52% (39%) for the 0.1-mg/kg and the 0.05-mg/kg studies, respectively. The ED50 based on the effective occupancy corresponds to 0.1 mg/kg, which is significantly smaller than the ED50 of 3 mg/kg calculated from studies in which [123]beta-CIT is displaced by cocaine. The effect on the Bmax estimate of two binding sites with different Kd's is also considered by simulation. We conclude (1) that the lack of robustness in the Bmax estimate limits the usefulness of any one subject's Bmax and suggests that the combination parameter Bmax/Kd (or the DVR), which has been used extensively, is a more stable measure of free receptor/transporter concentration. The average Bmax may, however, provide an estimate of the expected concentration in humans. (2) The DVR can be used as a measure of DAT occupancy without applying an explicit model. JF - Synapse (New York, N.Y.) AU - Logan, J AU - Volkow, N D AU - Fowler, J S AU - Wang, G J AU - Fischman, M W AU - Foltin, R W AU - Abumrad, N N AU - Vitkun, S AU - Gatley, S J AU - Pappas, N AU - Hitzemann, R AU - Shea, C E AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York, USA. logan@modbrain.chm.bnl.gov Y1 - 1997/12// PY - 1997 DA - December 1997 SP - 347 EP - 356 VL - 27 IS - 4 SN - 0887-4476, 0887-4476 KW - Carbon Radioisotopes KW - 0 KW - Carrier Proteins KW - Dopamine Plasma Membrane Transport Proteins KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - SLC6A3 protein, human KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Female KW - Nerve Tissue Proteins -- analysis KW - Corpus Striatum -- chemistry KW - Tomography, Emission-Computed KW - Carrier Proteins -- analysis KW - Cocaine-Related Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79421758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Concentration+and+occupancy+of+dopamine+transporters+in+cocaine+abusers+with+%5B11C%5Dcocaine+and+PET.&rft.au=Logan%2C+J%3BVolkow%2C+N+D%3BFowler%2C+J+S%3BWang%2C+G+J%3BFischman%2C+M+W%3BFoltin%2C+R+W%3BAbumrad%2C+N+N%3BVitkun%2C+S%3BGatley%2C+S+J%3BPappas%2C+N%3BHitzemann%2C+R%3BShea%2C+C+E&rft.aulast=Logan&rft.aufirst=J&rft.date=1997-12-01&rft.volume=27&rft.issue=4&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-14 N1 - Date created - 1998-01-14 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: Synapse. 1999 May;32(2):136-40 [10231133] Synapse. 1998 Oct;30(2):236-7 [9723794] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cold anticyclonic eddies formed from cold pool water in the southern Middle Atlantic Bight AN - 19886142; 8181375 AB - AVHRR satellite imagery of the southern Mid-Atlantic Bight during May 1993 revealed a large area of cold water over the shelf break and slope that appeared to spin up into a series of southward propagating anticyclonic eddies. The eddies had diameters of 35-45 km at the surface and moved southward at about 20 cm/sec. A radial TOYO CTD (to 50m) and ADCP velocity (to 400m) transect was conducted across the southern-most of these eddies. The upper 50 meters had minimum temperatures of less than 7 super(o)C and salinities of about 33 pss, characteristics similar to cold pool waters usually found over the continental shelf. ADCP velocity data from one of the eddies revealed anticyclonic flow extending to a depth of about 250m. The transport of cold pool water by the eddies was estimated to be 0.1 to 0.2 Sv which is of the same order as the annual mean alongshore transport of shelf water in this region. The origin of the deeper water within the eddy is unlikely to be the continental shelf because the shelf break is less than 100 m. The depth and velocity profiles along the TOYO transect were consistent with the constant potential vorticity eddy model of Flierl (1979) although the source of the eddy kinetic energy is uncertain. The cause for the exodus of cold pool water from the shelf, which extended northward to at least 38 super(o)N, is unclear but must involve the establishment of an alongshore baroclinic pressure gradient against the usual southwestward shelf flow. It is possible that the intrusion of Gulf Stream waters onto the shelf near Cape Hatteras was a precursor of this off shelf transport. The southern-most eddy was marked by high biological productivity and very high oxygen supersaturation. The phytoplankton bloom detected within the exported cold pool water, located over the continental slope, suggests a mechanism whereby production fueled by nutrients derived from the shelf can be locally exported into deep water. JF - Continental Shelf Research AU - Flagg, C N AU - Wallace, D AU - Kolber, Z AD - Department of Applied Sciences, Brookhaven National Laboratory Upton, NY 11973 USA Y1 - 1997/12// PY - 1997 DA - December 1997 SP - 1839 EP - 1867 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl] VL - 17 IS - 15 SN - 0278-4343, 0278-4343 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Ecology Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Oceanic Abstracts KW - Supersaturation KW - Current profiles KW - Acoustic current meters KW - Phytoplankton KW - Nutrients KW - Doppler sonar KW - Streams KW - Cold pools KW - Models KW - Deep water KW - Potential vorticity KW - Phytoplankton bloom KW - Salinity effects KW - Continental shelves KW - AVHRR (Advanced Very High Resolution Radiometer) KW - Current rings KW - Pressure KW - Temperature effects KW - Data processing KW - Continental slope KW - CTD observations KW - A, Atlantic, Gulf Stream KW - Gulf Stream KW - Minimum temperatures KW - Oceanic eddies KW - Satellites KW - ANW, USA, North Carolina, Cape Hatteras KW - Oxygen KW - Kinetic energy KW - ANW, USA, Mid-Atlantic Bight KW - Q2 09164:Ocean circulation and currents KW - K 03490:Miscellaneous KW - O 2010:Physical Oceanography KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies KW - M2 551.462:Submarine Topography/Bottom Forms/Sea-Floor Features (551.462) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19886142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Continental+Shelf+Research&rft.atitle=Cold+anticyclonic+eddies+formed+from+cold+pool+water+in+the+southern+Middle+Atlantic+Bight&rft.au=Flagg%2C+C+N%3BWallace%2C+D%3BKolber%2C+Z&rft.aulast=Flagg&rft.aufirst=C&rft.date=1997-12-01&rft.volume=17&rft.issue=15&rft.spage=1839&rft.isbn=&rft.btitle=&rft.title=Continental+Shelf+Research&rft.issn=02784343&rft_id=info:doi/10.1016%2FS0278-4343%2897%2900038-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Acoustic current meters; Current profiles; CTD observations; Continental shelves; Current rings; Phytoplankton; Doppler sonar; Oceanic eddies; Deep water; Temperature effects; Data processing; Continental slope; Nutrients; Streams; Satellites; Models; Oxygen; Kinetic energy; Salinity effects; Pressure; Supersaturation; Potential vorticity; Phytoplankton bloom; AVHRR (Advanced Very High Resolution Radiometer); Gulf Stream; Minimum temperatures; Cold pools; ANW, USA, North Carolina, Cape Hatteras; A, Atlantic, Gulf Stream; ANW, USA, Mid-Atlantic Bight DO - http://dx.doi.org/10.1016/S0278-4343(97)00038-1 ER - TY - JOUR T1 - Accurate headspace analysis of [fnof]CO sub(2) in discrete water samples using batch equilibration AN - 1808733328; PQ0003341153 AB - A high-accuracy, batch-equilibration, static-headspace technique for the determination of the fugacity of CO sub(2) (fCO sub(2)) in discrete water samples is described. The technique was designed for monitoring small changes of CO sub(2) in the ocean and has accuracy and precision (<1% for water samples) comparable to that of the best techniques available. The method uses several novel approaches to maximize accuracy, requires only a small water sample (60 ml), and is very rapid (~2 min per analysis). Precision of the calculated total alkalinity, based on the measured fCO sub(2) and CT, is comparable to or better than is generally attained using potentiometric titration. Compared with CT and total alkalinity measurements, the small sample volume and rapid analysis time makes it practical to perform analysis of multiple replicates in order to improve confidence in the result. The method is readily applicable to experimental studies such as incubations as well as to time-series measurements of in situ biological metabolism. Because the analysis employsgas chromatography, the technique can be acapted to measure simultaneously a suite of gases dissolved in seawater. JF - Limnology and Oceanography AU - Neill, Craig AU - Johnson, Kenneth M AU - Lewis, Ernie AU - Wallace, Douglas WR AD - Department of Applied Science, Brookhaven National Laboratory, P.0. Box 5000, Upton, New York 11973-5000. Y1 - 1997/12// PY - 1997 DA - December 1997 SP - 1774 EP - 1783 PB - Association for the Sciences of Limnology and Oceanography VL - 42 IS - 8 SN - 0024-3590, 0024-3590 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Water Analysis KW - Chromatographic techniques KW - Seawater KW - Water Sampling KW - Limnology KW - Alkalinity KW - Titration KW - Laboratory Equipment KW - Marine KW - Methodology KW - Sea water KW - Precision KW - Water samples KW - Monitoring KW - Carbon dioxide KW - Carbon Dioxide KW - AQ 00001:Water Resources and Supplies KW - Q1 08563:Fishing gear and methods KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808733328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Accurate+headspace+analysis+of+%5Bfnof%5DCO+sub%282%29+in+discrete+water+samples+using+batch+equilibration&rft.au=Neill%2C+Craig%3BJohnson%2C+Kenneth+M%3BLewis%2C+Ernie%3BWallace%2C+Douglas+WR&rft.aulast=Neill&rft.aufirst=Craig&rft.date=1997-12-01&rft.volume=42&rft.issue=8&rft.spage=1774&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1997.42.8.1774 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Sea water; Chromatographic techniques; Alkalinity; Titration; Water samples; Carbon dioxide; Methodology; Water Analysis; Seawater; Precision; Water Sampling; Limnology; Monitoring; Laboratory Equipment; Carbon Dioxide; Marine DO - http://dx.doi.org/10.4319/lo.1997.42.8.1774 ER - TY - JOUR T1 - Accurate headspace analysis of fCO sub(2) in discrete water samples using batch equilibration AN - 16552270; 4373102 AB - A high-accuracy, batch-equilibration, static-headspace technique for the determination of the fugacity of CO sub(2) (fCO sub(2)) in discrete water samples is described. The technique was designed for monitoring small changes of CO sub(2) in the ocean and has accuracy and precision (<1% for water samples) comparable to that of the best techniques available. The method uses several novel approaches to maximize accuracy, requires only a small water sample (60 ml), and is very rapid ( similar to 2 min per analysis). Precision of the calculated total alkalinity, based on the measured fCO sub(2) and C sub(T), is comparable to or better than is generally attained using potentiometric titration. Compared with C sub(T) and total alkalinity measurements, the small sample volume and rapid analysis time makes it practical to perform analysis of multiple replicates in order to improve confidence in the result. The method is readily applicable to experimental studies such as incubations as well as to time-series measurements of in situ biological metabolism. Because the analysis employs gas chromatography, the technique can be adapted to measure simultaneously a suite of gases dissolved in seawater. JF - Limnology and Oceanography AU - Neill, C AU - Johnson, K M AU - Lewis, E AU - Wallace, DWR AD - Department of Applied Science, Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973-5000, USA Y1 - 1997/12// PY - 1997 DA - Dec 1997 SP - 1774 EP - 1783 VL - 42 IS - 8 SN - 0024-3590, 0024-3590 KW - Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Marine KW - Analytical methods KW - Seawater KW - Alkalinity KW - Analytical techniques KW - Carbon dioxide KW - Water analysis KW - SW 5010:Network design KW - Q2 09184:Composition of water KW - O 2050:Chemical Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16552270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Accurate+headspace+analysis+of+fCO+sub%282%29+in+discrete+water+samples+using+batch+equilibration&rft.au=Neill%2C+C%3BJohnson%2C+K+M%3BLewis%2C+E%3BWallace%2C+DWR&rft.aulast=Neill&rft.aufirst=C&rft.date=1997-12-01&rft.volume=42&rft.issue=8&rft.spage=1774&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Alkalinity; Seawater; Analytical techniques; Carbon dioxide; Water analysis; Analytical methods; Marine ER - TY - JOUR T1 - Evaluation of modeled sulfate and SO sub(2) over North America and Europe for four seasonal months in 1986-1987 AN - 16396254; 4305910 AB - A three-dimensional Eulerian transport and transformation model driven by observation-derived synoptic meteorological data has been applied to calculate mixing ratios (MRs) of sulfate and SO sub(2) and wet deposition of sulfate over the North Atlantic and adjacent continental regions for 1-month periods in each of four seasons in 1986-1987. Model performance is evaluated by comparison of grid-cell average (1.125 degree ) modeled MRs for sulfate (24-hour average) and SO sub(2) (6- and 24-hour average) in the lowest model level (surface to similar to 65 m) to surface MRs observed at monitoring stations in North America and Europe. For sulfate similar to 8000 model-observation comparisons were made employing similar to 10,000 individual measurements; for 24-hour SO sub(2), 21,000 comparisons (54,000 measurements) and for 6-hour SO sub(2), similar to 71,000 comparisons (211,000 measurements). Subgrid variation of observed MRs is inferred from the spread of multiple simultaneous measurements within individual grid cells. The median spread of the observed MRs is a factor of 1.5 for 24-hour sulfate and 2.2 for 24-hour SO sub(2). The median spread between observed and modeled MRs is a factor of 2.3 for sulfate and 2.1 for 24-hour SO sub(2), comparable to that for the observations themselves. This suggests that much of the departure between modeled and observed MRs can be attributed to subgrid spatial variation and nonrepresentative sampling of model grid cells at the stations used for the comparisons. For SO sub(2) the median ratio of modeled to observed MRs is 0.97, with little seasonal variation, somewhat lower in North America but considerably higher in Europe; little difference was evidenced in comparisons of 6-hour averages versus 24-hour averages. For sulfate the median ratio is 0.51, with the range for the four simulation periods 0.36 to 0.66, lowest in January-February 1987, and with comparable values for Europe and North America. For all four simulations the time series of 24-hour average modeled MRs at most locations rather closely reproduce the magnitudes and temporal episodicity of the observed sulfate and SO sub(2) MRs. Analysis of correlations of observed and modeled MRs was carried out for all grid cell locations for which at least 25 days of observations were available in a simulation period; 76% of 203 correlations for 24-hour sulfate and 51% of 526 correlations for 24-hour SO sub(2) were significant at the 95% confidence level. The superior model performance in this respect for sulfate is attributed to the lower subgrid variation in the mixing ratio of this mainly secondary atmospheric species versus the mainly primary emitted species SO sub(2). Comparisons of modeled and observed sulfate wet deposition (concentration times precipitation amount) for similar to 300 daily and similar to 1100 weekly samples, all in North America, indicate a median spread between modeled and observed deposition of a factor of 2.6 and a median ratio of modeled to observed deposition of 0.82. The major contributor to model underestimation of sulfate MR in air is tentatively attributed to the lack of representation in the model of the aqueous-phase conversion of SO sub(2) to sulfate in nonprecipitating clouds. JF - Journal of Geophysical Research. D. Atmospheres AU - Benkovitz, C M AU - Schwartz, SE AD - Department of Applied Science, Brookhaven National Laboratory, Upton, NY, USA Y1 - 1997/11/20/ PY - 1997 DA - 1997 Nov 20 SP - 25 EP - 25,338 VL - 102 IS - D21 SN - 0148-0227, 0148-0227 KW - Europe KW - North America KW - Pollution Abstracts KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16396254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.atitle=Evaluation+of+modeled+sulfate+and+SO+sub%282%29+over+North+America+and+Europe+for+four+seasonal+months+in+1986-1987&rft.au=Benkovitz%2C+C+M%3BSchwartz%2C+SE&rft.aulast=Benkovitz&rft.aufirst=C&rft.date=1997-11-20&rft.volume=102&rft.issue=D21&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.issn=01480227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Contribution of carbonaceous aerosol to light scattering and hygroscopic growth in polluted continental air measured at Stable Island, Nova Scotia AN - 742919748; 2010-051124 JF - Eos, Transactions, American Geophysical Union AU - Bergin, M H AU - McInnes, L M AU - Ogren, J A AU - Schwartz, S E AU - Anonymous Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 106 PB - American Geophysical Union, Washington, DC VL - 78 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - carbonaceous composition KW - pollutants KW - atmosphere KW - measurement KW - Canada KW - solar radiation KW - Nova Scotia KW - Sable Island KW - aerosols KW - air KW - Maritime Provinces KW - wave dispersion KW - Eastern Canada KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742919748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Contribution+of+carbonaceous+aerosol+to+light+scattering+and+hygroscopic+growth+in+polluted+continental+air+measured+at+Stable+Island%2C+Nova+Scotia&rft.au=Bergin%2C+M+H%3BMcInnes%2C+L+M%3BOgren%2C+J+A%3BSchwartz%2C+S+E%3BAnonymous&rft.aulast=Bergin&rft.aufirst=M&rft.date=1997-11-01&rft.volume=78&rft.issue=46%2C+Suppl.&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1997 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - aerosols; air; atmosphere; Canada; carbonaceous composition; Eastern Canada; Maritime Provinces; measurement; Nova Scotia; pollutants; Sable Island; solar radiation; wave dispersion ER - TY - JOUR T1 - Synchrotron X-ray spectroscopy at ultrahigh pressures AN - 52161517; 2002-004062 JF - Eos, Transactions, American Geophysical Union AU - Mao, H K AU - Struzhkin, V V AU - Hemley, R J AU - Kao, C C AU - Anonymous Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 774 PB - American Geophysical Union, Washington, DC VL - 78 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - pressure KW - mantle KW - X-ray spectra KW - ultrahigh pressure KW - lower mantle KW - phase equilibria KW - metals KW - germanium KW - spectra KW - rare earths KW - anvil cells KW - chemical composition KW - geochemistry KW - P-T conditions KW - 17B:Geophysics of minerals and rocks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52161517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Synchrotron+X-ray+spectroscopy+at+ultrahigh+pressures&rft.au=Mao%2C+H+K%3BStruzhkin%2C+V+V%3BHemley%2C+R+J%3BKao%2C+C+C%3BAnonymous&rft.aulast=Mao&rft.aufirst=H&rft.date=1997-11-01&rft.volume=78&rft.issue=46%2C+Suppl.&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1997 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - anvil cells; chemical composition; geochemistry; germanium; lower mantle; mantle; metals; P-T conditions; phase equilibria; pressure; rare earths; spectra; ultrahigh pressure; X-ray spectra ER - TY - RPRT T1 - Transport of radionuclides in the Arctic seas AN - 51284969; 2008-028233 JF - Radionuclides in the Arctic seas from the former Soviet Union; potential health and ecological risks AU - Layton, David AU - Vaughn, P AU - Yarrington, L AU - Maxwell, R AU - Preller, R AU - Bean, J AU - Carroll, J AU - Fuhrmann, M AU - Rigor, I AU - Tucker, W A2 - Layton, David A2 - Edson, Rrobert A2 - Varela, Marilyn A2 - Napier, Bruce Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 36 VL - UCRL-CR-136696 KW - sea water KW - radioactivity KW - pollutants KW - Arctic region KW - sea ice KW - mathematical models KW - marine transport KW - radioactive waste KW - models KW - marine sediments KW - marine environment KW - ice KW - sediments KW - Arctic Ocean KW - ecology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51284969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Layton%2C+David%3BVaughn%2C+P%3BYarrington%2C+L%3BMaxwell%2C+R%3BPreller%2C+R%3BBean%2C+J%3BCarroll%2C+J%3BFuhrmann%2C+M%3BRigor%2C+I%3BTucker%2C+W&rft.aulast=Layton&rft.aufirst=David&rft.date=1997-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Transport+of+radionuclides+in+the+Arctic+seas&rft.title=Transport+of+radionuclides+in+the+Arctic+seas&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Availability - Lawrence Livermore National Laboratory, Livermore, CA, United States N1 - Document feature - illus. incl. 9 tables, sketch maps N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - A consumer's guide to phytoplankton primary productivity models AN - 1808728563; PQ0003341150 AB - We describe a classification system for daily phytoplankton primary productivity models based on four implicit levels of mathematical integration. Depth-integrated productivity models have appeared in the literature on average once every 2 years over the past four decades. All of these models can be related to a single formulation equating depth-integrated primary production ( capital sigma PP) to surface phytoplankton biomass (C sub(surf)), a photoadaptive variable (P super(b) sub(opt)), euphotic depth (Z sub(eu)), an irradiance-dependent function (F), and daylength (DL). The primary difference between models is the description of F, yet we found that irradiance has a relatively minor effect on variability in capital sigma PP. We also found that only a small fraction of variability in capital sigma PP can be attributed to vertical variability in phytoplankton biomass or variability in the light-limited slope for photosynthesis. Our results indicate that (1) differences between or within any model category have the potential to improve estimates of capital sigma PP by <10%, so long as equivalent parameterizations are used for C sub(surf) and Pb sub(opt), and (2) differences in estimates of global annual primary production are due almost entirely to differences in input biomass fields and estimates of the photoadaptive variable, Pb sub(opt), not to fundamental differences between model constructs. JF - Limnology and Oceanography AU - Behrenfeld, Michael J AU - Falkowski, Paul G AD - Department of Applied Science, Oceanographic and Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York 11973-5000. Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 1479 EP - 1491 PB - Association for the Sciences of Limnology and Oceanography VL - 42 IS - 7 SN - 0024-3590, 0024-3590 KW - Ecology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Classification systems KW - Variability KW - Irradiance KW - Limnology KW - Phytoplankton KW - Primary production KW - Models KW - Integration KW - Classification KW - Slopes KW - Modelling KW - Marine KW - Plankton surveys KW - Mathematical models KW - Primary Productivity KW - Oceanography KW - Biomass KW - Model Studies KW - AQ 00001:Water Resources and Supplies KW - Q1 08563:Fishing gear and methods KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies KW - K 03450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808728563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=A+consumer%27s+guide+to+phytoplankton+primary+productivity+models&rft.au=Behrenfeld%2C+Michael+J%3BFalkowski%2C+Paul+G&rft.aulast=Behrenfeld&rft.aufirst=Michael&rft.date=1997-11-01&rft.volume=42&rft.issue=7&rft.spage=1479&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1997.42.7.1479 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Classification systems; Plankton surveys; Mathematical models; Phytoplankton; Primary production; Modelling; Integration; Irradiance; Biomass; Models; Variability; Classification; Primary Productivity; Limnology; Oceanography; Slopes; Model Studies; Marine DO - http://dx.doi.org/10.4319/lo.1997.42.7.1479 ER - TY - JOUR T1 - Fluoro-norchloroepibatidine: Preclinical assessment of acute toxicity AN - 16283454; 4285560 AB - super(18)Fluoro-norchloroepibatidine (exo-2-(6-fluoro-3-pyridyl)-7-azabicyclo-[2.2.1]heptane [NEEP]), a labeled derivative of epibatidine, has shown promise for imaging brain nicotinic acetylcholine receptors with PET. We determined the dose-dependent effects of NEEP in conscious rats. NEEP (1.5 mu g/kg; administered intravenously) resulted in 30% mortality. Neither 0.5 mu g/kg or 0.25 mu g/kg NEEP resulted in any significant changes in cardiorespiratory parameters, but plasma catecholamines increased (2- to 3-fold). Further studies are needed to determine the safety of NEEP that are specifically designed to assess the catecholamine response. Our results suggest that it is not advisable to initiate human PET studies with [ super(18)F]-NEEP without further evidence supporting its safety. JF - Nuclear Medicine and Biology AU - Molina, P E AU - Ding, Yu-Shin AU - Carroll, F I AU - Liang, F AU - Volkow, N D AU - Pappas, N AU - Kuhar, M AU - Abumrad, N AU - Gatley, S J AU - Fowler, J S AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA Y1 - 1997/11// PY - 1997 DA - Nov 1997 SP - 743 EP - 747 VL - 24 IS - 8 SN - 0969-8051, 0969-8051 KW - acetylcholine receptors (nicotinic) KW - acute effects KW - alkaloids KW - epibatidine KW - fluoronorchloroepibatidine KW - positron emission tomography KW - rats KW - Toxicology Abstracts KW - X 24111:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16283454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Medicine+and+Biology&rft.atitle=Fluoro-norchloroepibatidine%3A+Preclinical+assessment+of+acute+toxicity&rft.au=Molina%2C+P+E%3BDing%2C+Yu-Shin%3BCarroll%2C+F+I%3BLiang%2C+F%3BVolkow%2C+N+D%3BPappas%2C+N%3BKuhar%2C+M%3BAbumrad%2C+N%3BGatley%2C+S+J%3BFowler%2C+J+S&rft.aulast=Molina&rft.aufirst=P&rft.date=1997-11-01&rft.volume=24&rft.issue=8&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=Nuclear+Medicine+and+Biology&rft.issn=09698051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification. AN - 79361638; 9347090 AB - Changes in GABA function have been postulated to be involved in alcohol tolerance, withdrawal and addiction. In this study we measured regional brain metabolic responses to lorazepam, to indirectly assess GABA function (benzodiazepines facilitate GABAergic neurotransmission), in alcoholics during early and late withdrawal. Brain metabolism was measured using PET and 2-deoxy-2[18F]fluoro-D-glucose after placebo (baseline) and after lorazepam (30 micrograms/kg intravenously) in 10 alcoholics and 16 controls. In the alcoholics evaluations were performed 2 to 3 weeks after detoxification and were repeated 6 to 8 weeks later. Controls were also evaluated twice at a 6 to 8 weeks interval. While during the initial evaluation metabolism was significantly lower for most brain regions in the alcoholics than in controls in the repeated evaluation the only significant differences were in cingulate and orbitofrontal cortex. Lorazepam-induced decrements in metabolism did not change with protracted alcohol withdrawal and the magnitude of these changes were similar in controls and alcoholics except for a trend towards a blunted response to lorazepam in orbitofrontal cortex in alcoholics during the second evaluation. Abnormalities in orbitofrontal cortex and cingulate gyrus in alcoholics are unlikely to be due to withdrawal since they persist 8 to 11 weeks after detoxification. The fact that there was only a trend of significance for an abnormal response to lorazepam in orbitofrontal cortex indicates that mechanisms other than GABA are involved in the brain metabolic abnormalities observed in alcoholic subjects. JF - Alcoholism, clinical and experimental research AU - Volkow, N D AU - Wang, G J AU - Overall, J E AU - Hitzemann, R AU - Fowler, J S AU - Pappas, N AU - Frecska, E AU - Piscani, K AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 1278 EP - 1284 VL - 21 IS - 7 SN - 0145-6008, 0145-6008 KW - Blood Glucose KW - 0 KW - GABA Modulators KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Lorazepam KW - O26FZP769L KW - Index Medicus KW - Frontal Lobe -- physiopathology KW - Reference Values KW - Blood Glucose -- metabolism KW - Gyrus Cinguli -- physiopathology KW - Frontal Lobe -- drug effects KW - Humans KW - Prefrontal Cortex -- physiopathology KW - Fluorodeoxyglucose F18 -- metabolism KW - Gyrus Cinguli -- drug effects KW - Prefrontal Cortex -- drug effects KW - Brain Mapping KW - Adult KW - Tomography, Emission-Computed KW - Middle Aged KW - Neuropsychological Tests KW - Male KW - Brain -- physiopathology KW - Alcoholism -- rehabilitation KW - Alcohol Withdrawal Delirium -- rehabilitation KW - Alcohol Withdrawal Delirium -- physiopathology KW - GABA Modulators -- pharmacology KW - Energy Metabolism -- physiology KW - Energy Metabolism -- drug effects KW - Brain -- drug effects KW - Alcoholism -- physiopathology KW - Lorazepam -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79361638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Regional+brain+metabolic+response+to+lorazepam+in+alcoholics+during+early+and+late+alcohol+detoxification.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BOverall%2C+J+E%3BHitzemann%2C+R%3BFowler%2C+J+S%3BPappas%2C+N%3BFrecska%2C+E%3BPiscani%2C+K&rft.aulast=Volkow&rft.aufirst=N&rft.date=1997-10-01&rft.volume=21&rft.issue=7&rft.spage=1278&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-16 N1 - Date created - 1997-12-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - An estimate by two methods of thyroid absorbed doses due to BRAVO fallout in several Northern Marshall Islands. AN - 79306955; 9314227 AB - Estimates of the thyroid absorbed doses due to fallout originating from the 1 March 1954 BRAVO thermonuclear test on Bikini Atoll have been made for several inhabited locations in the Northern Marshall Islands. Rongelap, Utirik, Rongerik and Ailinginae Atolls were also inhabited on 1 March 1954, where retrospective thyroid absorbed doses have previously been reconstructed. The current estimates are based primarily on external exposure data, which were recorded shortly after each nuclear test in the Castle Series, and secondarily on soil concentrations of 137Cs in samples collected in 1978 and 1988, along with aerial monitoring done in 1978. The external exposures and 137Cs soil concentrations were representative of the atmospheric transport and deposition patterns of the entire Castle Series tests and show that the BRAVO test was the major contributor to fallout exposure during the Castle series and other test series which were carried out in the Marshall Islands. These data have been used as surrogates for fission product radioiodines and telluriums in order to estimate the range of thyroid absorbed doses that may have occurred throughout the Marshall Islands. Dosimetry based on these two sets of estimates agreed within a factor of 4 at the locations where BRAVO was the dominant contributor to the total exposure and deposition. Both methods indicate that thyroid absorbed doses in the range of 1 Gy (100 rad) may have been incurred in some of the northern locations, whereas the doses at southern locations did not significantly exceed levels comparable to those from worldwide fallout. The results of these estimates indicate that a systematic medical survey for thyroid disease should be conducted, and that a more definitive dose reconstruction should be made for all the populated atolls and islands in the Northern Marshall Islands beyond Rongelap, Utirik, Rongerik and Ailinginae, which were significantly contaminated by BRAVO fallout. JF - Health physics AU - Musolino, S V AU - Greenhouse, N A AU - Hull, A P AD - Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 651 EP - 662 VL - 73 IS - 4 SN - 0017-9078, 0017-9078 KW - Air Pollutants, Radioactive KW - 0 KW - Cesium Radioisotopes KW - Iodine Radioisotopes KW - Radioactive Fallout KW - Soil Pollutants, Radioactive KW - Tellurium KW - NQA0O090ZJ KW - Index Medicus KW - United States KW - Animals KW - Plants, Edible KW - Gamma Rays KW - Humans KW - Fishes KW - Iodine Radioisotopes -- analysis KW - Food Contamination, Radioactive KW - Micronesia KW - Geography KW - Time Factors KW - Tellurium -- analysis KW - Cesium Radioisotopes -- analysis KW - Thyroid Gland -- chemistry KW - Cesium Radioisotopes -- pharmacokinetics KW - Nuclear Warfare KW - Air Pollutants, Radioactive -- analysis KW - Soil Pollutants, Radioactive -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79306955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=An+estimate+by+two+methods+of+thyroid+absorbed+doses+due+to+BRAVO+fallout+in+several+Northern+Marshall+Islands.&rft.au=Musolino%2C+S+V%3BGreenhouse%2C+N+A%3BHull%2C+A+P&rft.aulast=Musolino&rft.aufirst=S&rft.date=1997-10-01&rft.volume=73&rft.issue=4&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-23 N1 - Date created - 1997-10-23 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: Health Phys. 2011 Feb;100(2):228-9; author reply 229-30 [21399439] Erratum In: Health Phys 1997 Dec;73(6):962 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Pedologic assessment of radionuclide distributions; use of a radio-pedogenic index AN - 52625931; 1998-011032 JF - Soil Science Society of America Journal AU - Evans, C V AU - Morton, L S AU - Harbottle, G Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 1440 EP - 1449 PB - Soil Science Society of America, Madison, WI VL - 61 IS - 5 SN - 0361-5995, 0361-5995 KW - United States KW - isotopes KW - igneous rocks KW - granites KW - bismuth KW - lead KW - radioactive decay KW - radon KW - rubification KW - New Hampshire KW - Ra-226 KW - spatial variations KW - radioactive isotopes KW - plutonic rocks KW - Conway Granite KW - noble gases KW - sediments KW - protactinium KW - Haplorthods KW - horizons KW - Ac-228 KW - activity KW - soils KW - alkaline earth metals KW - pedogenesis KW - Ac-228/Pb-214 KW - radium KW - clastic sediments KW - background level KW - till KW - equilibrium KW - Spodosols KW - Pb-214 KW - metals KW - actinium KW - soil surveys KW - parent materials KW - thorium KW - surveys KW - uranium KW - melanization KW - Carroll County New Hampshire KW - actinides KW - polonium KW - 02D:Isotope geochemistry KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52625931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+Science+Society+of+America+Journal&rft.atitle=Pedologic+assessment+of+radionuclide+distributions%3B+use+of+a+radio-pedogenic+index&rft.au=Evans%2C+C+V%3BMorton%2C+L+S%3BHarbottle%2C+G&rft.aulast=Evans&rft.aufirst=C&rft.date=1997-10-01&rft.volume=61&rft.issue=5&rft.spage=1440&rft.isbn=&rft.btitle=&rft.title=Soil+Science+Society+of+America+Journal&rft.issn=03615995&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 33 N1 - PubXState - WI N1 - Document feature - illus. incl. 5 tables N1 - SuppNotes - N.H. Agric. Exp. Stn., Durham, Contrib. No. 1950 N1 - Last updated - 2012-06-07 N1 - CODEN - SSSJD4 N1 - SubjectsTermNotLitGenreText - Ac-228; Ac-228/Pb-214; actinides; actinium; activity; alkaline earth metals; background level; bismuth; Carroll County New Hampshire; clastic sediments; Conway Granite; equilibrium; granites; Haplorthods; horizons; igneous rocks; isotopes; lead; melanization; metals; New Hampshire; noble gases; parent materials; Pb-214; pedogenesis; plutonic rocks; polonium; protactinium; Ra-226; radioactive decay; radioactive isotopes; radium; radon; rubification; sediments; soil surveys; soils; spatial variations; Spodosols; surveys; thorium; till; United States; uranium ER - TY - JOUR T1 - Gravimetric preparation of gas phase working standards containing volatile halogenated compounds for oceanographic applications AN - 52614991; 1998-023742 JF - Deep-Sea Research. Part I: Oceanographic Research Papers AU - Happell, J D AU - Wallace, D W R Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 1725 EP - 1738 PB - Pergamon, Oxford-New York VL - 44 IS - 9-10 SN - 0967-0637, 0967-0637 KW - experimental studies KW - gaseous phase KW - geophysical methods KW - halogenated compounds KW - standardization KW - calibration KW - oceanography KW - transient tracers KW - gravity methods KW - volatiles KW - organic compounds KW - gravimetric preparation KW - volatile organic compounds KW - tracers KW - applications KW - geochemistry KW - 07:Oceanography KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52614991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+I%3A+Oceanographic+Research+Papers&rft.atitle=Gravimetric+preparation+of+gas+phase+working+standards+containing+volatile+halogenated+compounds+for+oceanographic+applications&rft.au=Happell%2C+J+D%3BWallace%2C+D+W+R&rft.aulast=Happell&rft.aufirst=J&rft.date=1997-10-01&rft.volume=44&rft.issue=9-10&rft.spage=1725&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+I%3A+Oceanographic+Research+Papers&rft.issn=09670637&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670637 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 11 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - DRPPD5 N1 - SubjectsTermNotLitGenreText - applications; calibration; experimental studies; gaseous phase; geochemistry; geophysical methods; gravimetric preparation; gravity methods; halogenated compounds; oceanography; organic compounds; standardization; tracers; transient tracers; volatile organic compounds; volatiles ER - TY - JOUR T1 - Brown tide blooms in Long Island's coastal waters linked to interannual variability in groundwater flow AN - 16264035; 4249540 AB - There has been a widespread increase in the reporting of harmful and 'nuisance' algal blooms in the coastal ocean over the past few decades. On the global scale this is suspected to be a consequence of coastal eutrophication, however, on a case-by-case basis there is usually insufficient evidence to discriminate between the effects of human and natural causal factors. Intense blooms of the 'Brown Tide' unicellular algae (Aureococcus anophagefferens) have occurred sporadically since 1985 in coastal waters of Eastern Long Island and have devastated the local commercial scallop fishery. Analysis of an 11-year time-series dataset from this region indicates that bloom intensity is correlated with higher salinities and inversely correlated with the discharge of groundwater. Laboratory and field studies suggest that whereas salinity is unlikely to represent a direct physiological control on Brown Tide blooms, the addition of inorganic nitrogen tends to inhibit Brown Tide blooms. Budget calculations indicate that the inorganic nitrogen supply from groundwater is 1-2 orders of magnitude higher than any other external source of nitrogen for this ecosystem. Biweekly time series data collected in 1995 demonstrate that Brown Tide blooms utilize dissolved organic nitrogen (DON) for growth, as evidenced by a large decrease in DON parallel with an increase in cell abundance. On an interannual basis, bloom intensity was also positively correlated with mean DON concentrations. We hypothesize that bloom initiation is regulated by the relative supply of inorganic and organic nitrogen, determined to a large extent by temporal variability in groundwater flow. The 1980s and 1990s were characterized by exceptionally high and interannually variable groundwater discharge, associated with a large-scale climate shift over the North Atlantic. This, coupled with the time-lagged discharge of groundwater with high nitrate concentrations resulting from increased fertilizer use and population increase during the 1960s and 1970s, may have been a key factor in the initiation of Brown Tide blooms in 1985. JF - GLOBAL CHANGE BIOL. AU - Laroche, J AU - Nuzzi, R AU - Waters, R AU - Wyman, K AU - Falkowski, P G AU - Wallace, DWR AD - Department of Applied Science, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 1997/10// PY - 1997 DA - Oct 1997 SP - 397 EP - 410 VL - 3 IS - 5 SN - 1354-1013, 1354-1013 KW - Aureococcus anophagefferens KW - USA, Long Island Sound KW - USA, New York, Long I. KW - annual variations KW - brown tides KW - seasonal variations KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Ecology Abstracts; Pollution Abstracts KW - Algal blooms KW - Climatic changes KW - Freshwater KW - Agricultural runoff KW - Seasonal variations KW - Algae KW - Rivers KW - River discharge KW - Brackish KW - Coastal waters KW - Groundwater pollution KW - Groundwater KW - Eutrophication KW - Flow rates KW - Ground water KW - Marine KW - ANW, USA, Long Island Sound KW - Marine pollution KW - K 03009:Algae KW - SW 3020:Sources and fate of pollution KW - P 1000:MARINE POLLUTION KW - Q5 08521:Mechanical and natural changes KW - D 04712:Environmental degradation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16264035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=GLOBAL+CHANGE+BIOL.&rft.atitle=Brown+tide+blooms+in+Long+Island%27s+coastal+waters+linked+to+interannual+variability+in+groundwater+flow&rft.au=Laroche%2C+J%3BNuzzi%2C+R%3BWaters%2C+R%3BWyman%2C+K%3BFalkowski%2C+P+G%3BWallace%2C+DWR&rft.aulast=Laroche&rft.aufirst=J&rft.date=1997-10-01&rft.volume=3&rft.issue=5&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=GLOBAL+CHANGE+BIOL.&rft.issn=13541013&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2014-05-06 N1 - SubjectsTermNotLitGenreText - Rivers; Algal blooms; Marine pollution; Eutrophication; Climatic changes; Ground water; River discharge; Groundwater pollution; Coastal waters; Seasonal variations; Agricultural runoff; Algae; Flow rates; Groundwater; Aureococcus anophagefferens; ANW, USA, Long Island Sound; Marine; Brackish; Freshwater ER - TY - JOUR T1 - UV effects in "the real world": problems of UV dosimetry in complex organisms. AN - 79289912; 9301040 AB - Understanding the effects of UV radiation on higher plants and animals is essential for evaluating the consequences of environmental changes which could alter the UV levels in the biosphere. Although analytical approaches for quantifying UV exposures and resulting cellular damage levels in optically simple systems (DNA in dilute solution, viruses or microorganisms in dilute suspension and monolayers of cultured cells) are well known, these methods may not be applicable to optically complex systems, such as multilayered plants and animals, or microorganisms in absorbing milieu such as natural lakes or oceans. Understanding the problems, pitfalls and solutions to the quantification of UV exposures and cellular damage is critical for evaluating the effects of environmental UV on complex organisms. JF - Journal of photochemistry and photobiology. B, Biology AU - Sutherland, B M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. sutherl3@bnl.gov Y1 - 1997/08// PY - 1997 DA - August 1997 SP - 8 EP - 13 VL - 40 IS - 1 SN - 1011-1344, 1011-1344 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Dose-Response Relationship, Radiation KW - Mutation KW - Plants -- radiation effects KW - Ultraviolet Rays KW - DNA Damage KW - Environmental Exposure KW - DNA -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79289912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.atitle=UV+effects+in+%22the+real+world%22%3A+problems+of+UV+dosimetry+in+complex+organisms.&rft.au=Sutherland%2C+B+M&rft.aulast=Sutherland&rft.aufirst=B&rft.date=1997-08-01&rft.volume=40&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.issn=10111344&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-07 N1 - Date created - 1997-10-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Dehydration dynamics of stilbite using synchrotron X-ray powder diffraction AN - 52676375; 1997-070865 AB - The continuous structural transformation of the natural zeolite stilbite (Na (sub 3.62) K (sub 0.44) Ba (sub 0.03) Ca (sub 6.32) Sr (sub 0.28) Mg (sub 0.04) [Fe (super 3+) (sub -0.01) Al (sub 17.33) Si (sub 54.64) O (sub 144) ].60H (sub 2) O) upon dehydration has been studied using Rietveld structure analysis of temperature-resolved powder diffraction data collected with synchrotron radiation. In the initial stage of heating, the monoclinic F2/m stilbite structure (the so-called A phase) behaves as a noncollapsible framework, featuring only a slight framework distortion and a slight cell-volume contraction. At about 420 K, a first-order phase transition occurs changing the symmetry to an orthorhombic Amma phase, whose framework is collapsible and shows a large cell-volume contraction with temperature. The cell contraction is related to the process of T-O-T bond breaking and leads to a high-temperature stilbite phase with the same Amma space group and a collapsed structure similar to the previously described B phase in stellerite and barrerite. The structural refinement indicates that the dynamics of bond breaking is related to the shift of the Ca cations in the channels to achieve optimal coordination after the release of the H (sub 2) O molecules. Refined statistical occupancies of the tetrahedral atoms involved in the bond-breaking process (T1 and T1P) are consistent with a random rupture and re-formation of the T-O-T bonds. This is the first experimental study of the dynamic bond breaking of T-O-T bonds in a framework structure. JF - American Mineralogist AU - Cruciani, Giuseppe AU - Artioli, Gilberto AU - Gualtieri, Alessandro AU - Stahl, Kenny AU - Hanson, Jonathan C Y1 - 1997/08// PY - 1997 DA - August 1997 SP - 729 EP - 739 PB - Mineralogical Society of America, Washington, DC VL - 82 IS - 7-8 SN - 0003-004X, 0003-004X KW - silicates KW - cell dimensions KW - X-ray diffraction data KW - stilbite KW - zeolite group KW - framework silicates KW - crystal structure KW - dehydration KW - Rietveld refinement KW - powder method KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52676375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Dehydration+dynamics+of+stilbite+using+synchrotron+X-ray+powder+diffraction&rft.au=Cruciani%2C+Giuseppe%3BArtioli%2C+Gilberto%3BGualtieri%2C+Alessandro%3BStahl%2C+Kenny%3BHanson%2C+Jonathan+C&rft.aulast=Cruciani&rft.aufirst=Giuseppe&rft.date=1997-08-01&rft.volume=82&rft.issue=7-8&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 31 N1 - PubXState - DC N1 - Document feature - 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - cell dimensions; crystal structure; dehydration; framework silicates; powder method; Rietveld refinement; silicates; stilbite; X-ray diffraction data; zeolite group ER - TY - JOUR T1 - Single-crystal neutron-diffraction study of pyrope in the temperature range 30-1173 K AN - 52594886; 1998-042215 AB - Single-crystal neutron-diffraction data collected from a pyrope crystal from the Dora Maira Massif, Western Alps, Italy, expands the structure analysis of synthetic end-member pyrope over a wide T range. The atomic displacement properties were analysed by the higher cumulant model in the Gram-Charlier series approximation and show that the anharmonic contribution to the dynamic part of the Mg site displacement is significant above 700 K. No evidence was found for static site disorder in the dodecahedral Mg site by refinement with split-atom models, and the intercept at 0 K resulting from linear interpolation of the high-T harmonic displacement coefficients is not statistically significant. The refinement of high-order displacement-tensor components results in significantly lower figures of merit in the whole explored T range. JF - The Canadian Mineralogist AU - Artioli, Gilberto AU - Pavese, Alessandro AU - Stahl, Kenny AU - McMullan, Richard K Y1 - 1997/08// PY - 1997 DA - August 1997 SP - 1009 EP - 1019 PB - Mineralogical Association of Canada, Ottawa, ON VL - 35, Part 4 SN - 0008-4476, 0008-4476 KW - silicates KW - Western Europe KW - Cottian Alps KW - Alps KW - garnet group KW - Europe KW - crystal structure KW - Dora Maira Massif KW - pyrope KW - Italy KW - temperature KW - Southern Europe KW - Piemonte Italy KW - nesosilicates KW - single-crystal method KW - orthosilicates KW - neutron diffraction data KW - thermodynamic properties KW - Piedmont Alps KW - high temperature KW - Western Alps KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52594886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Canadian+Mineralogist&rft.atitle=Single-crystal+neutron-diffraction+study+of+pyrope+in+the+temperature+range+30-1173+K&rft.au=Artioli%2C+Gilberto%3BPavese%2C+Alessandro%3BStahl%2C+Kenny%3BMcMullan%2C+Richard+K&rft.aulast=Artioli&rft.aufirst=Gilberto&rft.date=1997-08-01&rft.volume=35%2C+Part+4&rft.issue=&rft.spage=1009&rft.isbn=&rft.btitle=&rft.title=The+Canadian+Mineralogist&rft.issn=00084476&rft_id=info:doi/ L2 - http://www.mineralogicalassociation.ca/template/EJournal/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1998-01-01 N1 - Number of references - 34 N1 - PubXState - ON N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - CAMIA6 N1 - SubjectsTermNotLitGenreText - Alps; Cottian Alps; crystal structure; Dora Maira Massif; Europe; garnet group; high temperature; Italy; nesosilicates; neutron diffraction data; orthosilicates; Piedmont Alps; Piemonte Italy; pyrope; silicates; single-crystal method; Southern Europe; temperature; thermodynamic properties; Western Alps; Western Europe ER - TY - JOUR T1 - Sorption/desorption of radioactive contaminants by sediment from the Kara Sea AN - 52367484; 2000-027320 JF - The Science of the Total Environment AU - Fuhrmann, Mark AU - Zhou, Huan AU - Neiheisel, James AU - Schoonen, Martin A A AU - Dyer, Robert A2 - Strand, Per A2 - Howard, Brenda A2 - Cooke, Andrew Y1 - 1997/08// PY - 1997 DA - August 1997 SP - 5 EP - 24 PB - Elsevier, Amsterdam VL - 202 IS - 1-3 SN - 0048-9697, 0048-9697 KW - sorption KW - desorption KW - sea water KW - isotopes KW - Am-241 KW - lead KW - radioactive waste KW - partitioning KW - marine sediments KW - radioactive isotopes KW - mineral composition KW - cesium KW - sediments KW - Arctic Ocean KW - kinetics KW - technetium KW - alkaline earth metals KW - pollutants KW - alkali metals KW - pollution KW - Tc-99 KW - Sr-85 KW - Kara Sea KW - Cs-137 KW - metals KW - americium KW - waste disposal KW - actinides KW - strontium KW - Pb-210 KW - 07:Oceanography KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52367484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+Total+Environment&rft.atitle=Sorption%2Fdesorption+of+radioactive+contaminants+by+sediment+from+the+Kara+Sea&rft.au=Fuhrmann%2C+Mark%3BZhou%2C+Huan%3BNeiheisel%2C+James%3BSchoonen%2C+Martin+A+A%3BDyer%2C+Robert&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=1997-08-01&rft.volume=202&rft.issue=1-3&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+Total+Environment&rft.issn=00489697&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Second symposium and international conference on Environmental radioactivity in the Arctic N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 23 N1 - Document feature - illus. incl. 3 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - actinides; alkali metals; alkaline earth metals; Am-241; americium; Arctic Ocean; cesium; Cs-137; desorption; isotopes; Kara Sea; kinetics; lead; marine sediments; metals; mineral composition; partitioning; Pb-210; pollutants; pollution; radioactive isotopes; radioactive waste; sea water; sediments; sorption; Sr-85; strontium; Tc-99; technetium; waste disposal ER - TY - JOUR T1 - Repeated administration of 3,4-methylenedioxymethamphetamine augments cocaine's action on dopamine in the nucleus accumbens: a microdialysis study. AN - 79234783; 9274936 AB - In this study, we examined the ability of a single injection of cocaine (20 mg/kg, i.p.) to augment extracellular dopamine levels in the nucleus accumbens two weeks after pretreating rats with either saline (1 ml/kg, i.p.) or the serotonin neurotoxin 3,4-methylenedioxymethamphetamine (20 mg/kg, s.c., twice daily for 4 days). The level of dopamine in the nucleus accumbens was measured using in vivo microdialysis. Cocaine produced a 400% increase in extracellular nucleus accumbens dopamine levels in control rats, whereas in 3,4-methylenedioxymethamphetamine treated rats the increase produced by cocaine was 800%, which was significantly different from controls. This suggests that 3,4-methylenedioxymethamphetamine, a relatively common drug of abuse, may alter subsequent vulnerability to cocaine dependence and abuse. JF - European journal of pharmacology AU - Morgan, A E AU - Horan, B AU - Dewey, S L AU - Ashby, C R AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997/07/16/ PY - 1997 DA - 1997 Jul 16 SP - R1 EP - R3 VL - 331 IS - 1 SN - 0014-2999, 0014-2999 KW - Dopamine Uptake Inhibitors KW - 0 KW - Serotonin Agents KW - Cocaine KW - I5Y540LHVR KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Microdialysis KW - Animals KW - Rats, Sprague-Dawley KW - Substance-Related Disorders -- etiology KW - Drug Synergism KW - Male KW - Nucleus Accumbens -- drug effects KW - Serotonin Agents -- administration & dosage KW - Nucleus Accumbens -- metabolism KW - Dopamine -- metabolism KW - Cocaine -- pharmacology KW - N-Methyl-3,4-methylenedioxyamphetamine -- administration & dosage KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79234783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Repeated+administration+of+3%2C4-methylenedioxymethamphetamine+augments+cocaine%27s+action+on+dopamine+in+the+nucleus+accumbens%3A+a+microdialysis+study.&rft.au=Morgan%2C+A+E%3BHoran%2C+B%3BDewey%2C+S+L%3BAshby%2C+C+R&rft.aulast=Morgan&rft.aufirst=A&rft.date=1997-07-16&rft.volume=331&rft.issue=1&rft.spage=R1&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-12 N1 - Date created - 1997-09-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Historical events associated with fallout from Bravo Shot--Operation Castle and 25 Y of medical findings. AN - 79093075; 9199227 AB - The events prior to Bravo Shot-Operation Castle that led to a decision not to evacuate the Marshallese prior to testing the thermonuclear bombs are presented as are the actions taken after the fallout incident in evacuating the exposed Marshallese and the military personnel. The initial medical effects (findings during first 6 wk after exposure) are briefly described and are followed by description of long term effects, namely, induction of one case of fatal acute myeloid leukemia and a large number of thyroid tumors (benign and malignant) in addition to hypothyroidism in adults and children and two cases of cretinism. The hypothyroidism and cretinism responded well to administration of oral thyroxine. During the first 25 y, there was also much unrest and political agitation initiated by exposed and unexposed Marshallese who were very unhappy as a result of relocation and inability to return to their homelands and feeling that all illness and deaths were due to the mysterious radiation, which they understandably did not understand. The difficulties in part were ameliorated by financial aid from the U.S. Congress. In view of one of us (EPC), no one agency or person in the U.S. Government was willing to take the responsibility for care of the Marshallese and its financing. The exposed and nonexposed Marshallese had their lifestyle changed, some of their homelands made uninhabitable for several years and could aptly be called "nuclear nomads," an expression coined by others. JF - Health physics AU - Cronkite, E P AU - Conard, R A AU - Bond, V P AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997/07// PY - 1997 DA - July 1997 SP - 176 EP - 186 VL - 73 IS - 1 SN - 0017-9078, 0017-9078 KW - Radioactive Fallout KW - 0 KW - Index Medicus KW - Blood Cell Count -- radiation effects KW - Radiation Dosage KW - Radioactive Hazard Release KW - Humans KW - Micronesia KW - Thyroid Gland -- radiation effects KW - Nuclear Warfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79093075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Historical+events+associated+with+fallout+from+Bravo+Shot--Operation+Castle+and+25+Y+of+medical+findings.&rft.au=Cronkite%2C+E+P%3BConard%2C+R+A%3BBond%2C+V+P&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1997-07-01&rft.volume=73&rft.issue=1&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-07-10 N1 - Date created - 1997-07-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Gastrointestinal absorption of plutonium by the Marshall Islanders. AN - 79079964; 9199226 AB - The gastrointestinal absorption constant (f1) is a critical parameter in assessing systemic uptake following the ingestion of a radioactive material and in monitoring such intakes. This study addresses the latter, particularly for plutonium, and from environmental measurements derives an f1 value of 4 x 10(-4) for the Marshallese population. The uncertainty associated with the methodology and measurements used in this f1 value assessment is evaluated. This evaluation takes into account the results from 24-h urine samples and the particular lifestyle of the Marshallese. Plutonium intake resulting from soil consumption is a primary parameter in this evaluation; for this study, it was assumed to be 500 mg d(-1). The f1 value determined here is consistent with the values in ICRP Publication 67 of 5x10(-4) for ages 1 to adult, and is the same as that suggested by the NRPB. JF - Health physics AU - Sun, L C AU - Meinhold, C B AD - Department of Advanced Technology, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997/07// PY - 1997 DA - July 1997 SP - 167 EP - 175 VL - 73 IS - 1 SN - 0017-9078, 0017-9078 KW - Soil Pollutants, Radioactive KW - 0 KW - Plutonium KW - 53023GN24M KW - Index Medicus KW - Humans KW - Adult KW - Micronesia KW - Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Soil Pollutants, Radioactive -- pharmacokinetics KW - Plutonium -- pharmacokinetics KW - Nuclear Warfare KW - Intestinal Absorption UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79079964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Gastrointestinal+absorption+of+plutonium+by+the+Marshall+Islanders.&rft.au=Sun%2C+L+C%3BMeinhold%2C+C+B&rft.aulast=Sun&rft.aufirst=L&rft.date=1997-07-01&rft.volume=73&rft.issue=1&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-07-10 N1 - Date created - 1997-07-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Assessment of plutonium exposure in the Enewetak population by urinalysis. AN - 79079941; 9199223 AB - Since 1980, the inhabitants of Enewetak Atoll have been monitored periodically by scientists from Brookhaven National Laboratory for internally deposited radioactive material. In 1989, the establishment of fission track analysis and of a protocol for shipboard collection of 24-h urine samples significantly improved our ability to assess the internal uptake of plutonium. The purpose of this report is to show the distribution of plutonium concentrations in urine collected in 1989 and 1991, and to assess the associated committed effective doses for the Enewetak population based on a long-term chronic uptake of low-level plutonium. To estimate dose, we derived the plutonium dose-per-unit-uptake coefficients based on the dosimetric system of the International Commission on Radiological Protection. Assuming a continuous uptake, an integrated Jones's plutonium urine excretion function was developed to interpret the Enewetak urine data. The Appendix shows how these values were derived. The committed effective doses were 0.2 mSv, calculated from the 1991 average plutonium content in 69 urine samples. JF - Health physics AU - Sun, L C AU - Meinhold, C B AU - Moorthy, A R AU - Kaplan, E AU - Baum, J W AD - Department of Advanced Technology, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997/07// PY - 1997 DA - July 1997 SP - 127 EP - 132 VL - 73 IS - 1 SN - 0017-9078, 0017-9078 KW - Plutonium KW - 53023GN24M KW - Index Medicus KW - Infant KW - Radiation Dosage KW - Humans KW - Adult KW - Micronesia KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Child, Preschool KW - Nuclear Warfare KW - Plutonium -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79079941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Assessment+of+plutonium+exposure+in+the+Enewetak+population+by+urinalysis.&rft.au=Sun%2C+L+C%3BMeinhold%2C+C+B%3BMoorthy%2C+A+R%3BKaplan%2C+E%3BBaum%2C+J+W&rft.aulast=Sun&rft.aufirst=L&rft.date=1997-07-01&rft.volume=73&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-07-10 N1 - Date created - 1997-07-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - 137Cs exposure in the Marshallese populations: an assessment based on whole-body counting measurements (1989-1994). AN - 79079734; 9199220 AB - The Marshall Islands were the site of numerous tests of nuclear weapons by the United States. From 1946 to 1958, nuclear devices were detonated at Enewetak and Bikini Atolls. Following the inadvertent contamination of the northern islands downwind of the 1954 Bravo Test, Brookhaven National Laboratory became involved in the medical care and the radiological safety of the affected populations. One important technique employed in assessing the internally deposited radionuclides is whole-body counting. To estimate current and future exposures to 137Cs, data from 1989 to 1994 were analyzed and are reported in this paper. During this period, 3,618 measurements were made for the Marshallese. The cesium body contents were assumed to result from a series of chronic intakes. Also, it was assumed that cesium activity in the body reaches a plateau that is maintained over 365 d. We estimated the annual effective dose rate for each population, derived from the recommendations of the International Commission on Radiological Protection. The average 137Cs uptake measured by the whole-body counting method varies from one population to another; it was consistent with measurements of external exposure rate. The analysis, though based on limited data, indicates that there is no statistical support for a seasonal effect on 137Cs uptake. The critical population group for cesium uptake is adult males. Within the 5-y monitoring period, all internal exposures to 137Cs were less than 0.2 mSv y(-1). Similarly, a persistent average cesium effective dose rate of 2 microSv y(-1) was determined for Majuro residents. JF - Health physics AU - Sun, L C AU - Clinton, J H AU - Kaplan, E AU - Meinhold, C B AD - Department of Advanced Technology, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997/07// PY - 1997 DA - July 1997 SP - 86 EP - 99 VL - 73 IS - 1 SN - 0017-9078, 0017-9078 KW - Cesium Radioisotopes KW - 0 KW - Index Medicus KW - Infant KW - Radiation Dosage KW - Humans KW - Body Burden KW - Seasons KW - Adult KW - Infant, Newborn KW - Environmental Exposure KW - Micronesia KW - Child KW - Adolescent KW - Time Factors KW - Child, Preschool KW - Cesium Radioisotopes -- analysis KW - Nuclear Warfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79079734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=137Cs+exposure+in+the+Marshallese+populations%3A+an+assessment+based+on+whole-body+counting+measurements+%281989-1994%29.&rft.au=Sun%2C+L+C%3BClinton%2C+J+H%3BKaplan%2C+E%3BMeinhold%2C+C+B&rft.aulast=Sun&rft.aufirst=L&rft.date=1997-07-01&rft.volume=73&rft.issue=1&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-07-10 N1 - Date created - 1997-07-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Analysis of a Streptococcus pneumoniae gene encoding signal peptidase I and overproduction of the enzyme AN - 16030622; 4089304 AB - The spi gene of Streptococcus pneumoniae was cloned and its nucleotide sequence was determined. It encodes a protein of 204 amino acids that is homologous to bacterial signal peptidase I proteins. The S. pneumoniae protein contains all of the conserved amino acid sequence motifs previously identified in this enzyme from both prokaryotic and eukaryotic sources. Sequence comparisons revealed several additional motifs characteristic of the enzyme. The cloned S. pneumoniae gene complemented an Escherichia coli mutant defective in its leader peptidase gene. Expression of the spi gene in S. pneumoniae appeared to be essential for viability. The cloned gene was shown to produce a polypeptide of approximately 20 kDa. Overproduction of the S. pneumoniae spi gene in an E. coli expression system gave a native protein product, soluble in the presence of a non-ionic detergent, which should be amenable to structural determination. JF - Gene AU - Zhang, Yian-Biao AU - Greenberg, B AU - Lacks, SA AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 1997/07// PY - 1997 DA - Jul 1997 SP - 249 EP - 255 PB - ELSEVIER SCIENCE B.V. VL - 194 IS - 2 SN - 0378-1119, 0378-1119 KW - nucleotide sequence KW - gene expression KW - spi gene KW - signal peptidase I KW - leader peptidase KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Streptococcus pneumoniae KW - complementation KW - Escherichia coli KW - G 07321:GENERAL KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16030622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Analysis+of+a+Streptococcus+pneumoniae+gene+encoding+signal+peptidase+I+and+overproduction+of+the+enzyme&rft.au=Zhang%2C+Yian-Biao%3BGreenberg%2C+B%3BLacks%2C+SA&rft.aulast=Zhang&rft.aufirst=Yian-Biao&rft.date=1997-07-01&rft.volume=194&rft.issue=2&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Escherichia coli; complementation ER - TY - JOUR T1 - Impaired permeability in radiation-induced lung injury detected by technetium-99m-DTPA lung clearance. AN - 79057170; 9189152 AB - UNLABELLEDThis study evaluates the use of the 99mTc-DTPA aerosol lung clearance method to investigate radiation-induced lung changes in eight patients undergoing radiotherapy for lung or breast carcinoma. The sensitivity of the method was compared with chest radiography for detecting radiation-induced changes in the lung, regional alterations within (irradiated region) and outside (shielded region) the treatment ports, effect of irradiated lung volume, and dependence on time after radiotherapy.METHODSSerial DTPA lung clearance studies were performed before the first radiation treatment (baseline), then weekly during a 5- to 7-wk course, and up to 12 times post-therapy over periods of 56-574 days. The total activity deposited in the lungs for each study was approximately 150 microCi (approximately 5.6 MBq). DTPA clearance, expressed in terms of the biological half-time, t 1/2, was computed from the slopes of the least-squares fit regression lines of the time-activity curves for the first 10 min for irradiated and shielded lung regions.RESULTSMajor findings include: (a) significant and early DTPA t 1/2 changes were observed in all patients during and after radiotherapy; (b) changes in DTPA t 1/2 values were observed in both irradiated and shielded lung regions in all patients suggesting a radiation-induced systemic reaction; (c) changes in DTPA t 1/2 values were correlated (p < 0.05) with the irradiated lung volumes; (d) significantly reduced DTPA t 1/2 values were observed in three patients who subsequently presented with clinical symptoms and/or radiographic changes consistent with radiation pneumonitis (t1/2 felt to 19% +/- 6% of baseline values, compared with 64% +/- 17% in the remaining patients [p < 0.01]); (e) the onset of decreased DTPA t 1/2 values in these three patients occurred 35-84 days before clinical symptoms and/or radiographic changes; and (f) DTPA t 1/2 tended to approach baseline values with time after radiotherapy, suggesting a long-term recovery in lung injury.CONCLUSIONThese observations show significant and early alterations in DTPA lung clearance during and after radiotherapy that may provide a sensitive assay to monitor changes in radiation-induced lung injury and may facilitate early therapeutic intervention. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Susskind, H AU - Weber, D A AU - Lau, Y H AU - Park, T L AU - Atkins, H L AU - Franceschi, D AU - Meek, A G AU - Ivanovic, M AU - Wielopolski, L AD - Clinical Research Center, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 966 EP - 971 VL - 38 IS - 6 SN - 0161-5505, 0161-5505 KW - Aerosols KW - 0 KW - Radiopharmaceuticals KW - Technetium Tc 99m Pentetate KW - VW78417PU1 KW - Index Medicus KW - Sensitivity and Specificity KW - Lung Neoplasms -- radiotherapy KW - Humans KW - Middle Aged KW - Breast Neoplasms -- radiotherapy KW - Male KW - Female KW - Radionuclide Imaging KW - Lung -- diagnostic imaging KW - Radiation Pneumonitis -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79057170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Impaired+permeability+in+radiation-induced+lung+injury+detected+by+technetium-99m-DTPA+lung+clearance.&rft.au=Susskind%2C+H%3BWeber%2C+D+A%3BLau%2C+Y+H%3BPark%2C+T+L%3BAtkins%2C+H+L%3BFranceschi%2C+D%3BMeek%2C+A+G%3BIvanovic%2C+M%3BWielopolski%2C+L&rft.aulast=Susskind&rft.aufirst=H&rft.date=1997-06-01&rft.volume=38&rft.issue=6&rft.spage=966&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-07-14 N1 - Date created - 1997-07-14 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: J Nucl Med. 1998 Feb;39(2):374 [9476953] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Estimating Exposure to Methylmercury: Effects of Uncertainties AN - 755135845; 13635078 AB - Uncertainties in exposures can lead to biased estimates of slopes and thresholds in the exposure-response relationships that are developed from regression analysis. This paper reviews published exposure and epidemiological studies of methylmercury (MeHg) from the perspective of the accuracy and precision of the estimates used to represent the actual doses received. Sources of such uncertainties, collectively referred to as QUOTATION_MARKexposure errorsQUOTATION_MARK, include instrumental and analytical errors, sampling and survey uncertainties, and individual variability in the relationships between the exposure metrics and the actual doses to target organs. Because the relationship between maternal intake and the consequent dose to the fetal brain varies among individuals, epidemiological studies of the effects of prenatal exposure must necessarily be accompanied by larger exposure uncertainties than comparable studies of effects on the mothers. The increased exposure errors typically result in attenuated slopes of the dose-response functions and under-estimates of thresholds, so that part of the apparent increased sensitivity of the fetus that has been developed from epidemiological studies may in fact be due to their inherently less certain exposures. Sources and magnitudes of exposure error found in the literature are discussed and their statistical ramifications are explored with Monte Carlo simulations. The paper also finds that, after adjusting for exposure error, the relationship between dietary intake and blood concentration is consistent with an average half-life shorter than has typically been used and that using population averages yields a consistent but sub-linear relationship between dietary intake of Hg and hair concentration. Investigators are urged to obtain (and present) data on more than one exposure metric, so that their relative uncertainties may be assessed independently. JF - Water, Air, & Soil Pollution AU - Lipfert, Frederick W AD - Department of Applied Science, Brookhaven National Laboratory, Upton, NY, 11973 Y1 - 1997/06// PY - 1997 DA - Jun 1997 SP - 119 EP - 145 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 97 IS - 1-2 SN - 0049-6979, 0049-6979 KW - Environment Abstracts; Pollution Abstracts KW - Brain KW - Diets KW - P 5000:LAND POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755135845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Estimating+Exposure+to+Methylmercury%3A+Effects+of+Uncertainties&rft.au=Lipfert%2C+Frederick+W&rft.aulast=Lipfert&rft.aufirst=Frederick&rft.date=1997-06-01&rft.volume=97&rft.issue=1-2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/10.1023%2FA%3A1018371414292 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Diets DO - http://dx.doi.org/10.1023/A:1018371414292 ER - TY - JOUR T1 - Characterization of sulfur-containing functional groups in sedimentary humic substances by X-ray absorption near-edge structure spectroscopy AN - 50313039; 1998-000515 JF - Energy & Fuels AU - Vairavamurthy, Murthy A AU - Maletic, Dusan AU - Wang, Shenkhe AU - Manowitz, Bernard AU - Eglinton, Timothy I AU - Lyons, Timothy AU - Anonymous Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 546 EP - 553 PB - American Chemical Society, [Washington, DC] VL - 11 IS - 3 SN - 0887-0624, 0887-0624 KW - degradation KW - humic acids KW - NMR spectra KW - organic compounds KW - organic acids KW - humic substances KW - X-ray data KW - chemical reactions KW - marine environment KW - diagenesis KW - sulfur KW - anaerobic environment KW - spectra KW - reduction KW - kerogen KW - preservation KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50313039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Energy+%26+Fuels&rft.atitle=Characterization+of+sulfur-containing+functional+groups+in+sedimentary+humic+substances+by+X-ray+absorption+near-edge+structure+spectroscopy&rft.au=Vairavamurthy%2C+Murthy+A%3BMaletic%2C+Dusan%3BWang%2C+Shenkhe%3BManowitz%2C+Bernard%3BEglinton%2C+Timothy+I%3BLyons%2C+Timothy%3BAnonymous&rft.aulast=Vairavamurthy&rft.aufirst=Murthy&rft.date=1997-06-01&rft.volume=11&rft.issue=3&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Energy+%26+Fuels&rft.issn=08870624&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - ACS national meeting, Division of Geochemistry N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 56 N1 - PubXState - DC] N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ENFUEM N1 - SubjectsTermNotLitGenreText - anaerobic environment; chemical reactions; degradation; diagenesis; humic acids; humic substances; kerogen; marine environment; NMR spectra; organic acids; organic compounds; preservation; reduction; spectra; sulfur; X-ray data ER - TY - JOUR T1 - Interactions of thiols with sedimentary particulate phase; studies of 3-mercaptopropionate in salt marsh sediments from Shelter Island, New York AN - 50308031; 1998-029119 JF - Organic Geochemistry AU - Vairavamurthy, Murthy A AU - Manowitz, Bernard AU - Maletic, Dusan AU - Wolfe, Helen A2 - Sinninghe Damste, Jaap S. Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 577 EP - 585 PB - Pergamon, Oxford-New York VL - 26 IS - 9-10 SN - 0146-6380, 0146-6380 KW - United States KW - Monocotyledoneae KW - Spermatophyta KW - humic acids KW - cores KW - marine sediments KW - thiols KW - sediments KW - Spartina KW - particulate materials KW - geochemistry KW - organic sulfur KW - Spartina alterniflora KW - processes KW - biodegradation KW - Plantae KW - marshes KW - 3-mercaotoproprionate KW - organic compounds KW - organic acids KW - New York KW - mires KW - humic substances KW - salt marshes KW - Shelter Island KW - sulfur KW - anaerobic environment KW - Gramineae KW - preservation KW - Angiospermae KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50308031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+Geochemistry&rft.atitle=Interactions+of+thiols+with+sedimentary+particulate+phase%3B+studies+of+3-mercaptopropionate+in+salt+marsh+sediments+from+Shelter+Island%2C+New+York&rft.au=Vairavamurthy%2C+Murthy+A%3BManowitz%2C+Bernard%3BMaletic%2C+Dusan%3BWolfe%2C+Helen&rft.aulast=Vairavamurthy&rft.aufirst=Murthy&rft.date=1997-06-01&rft.volume=26&rft.issue=9-10&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Organic+Geochemistry&rft.issn=01466380&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/01466380 LA - English DB - GeoRef N1 - Conference title - Spring 1996 national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 55 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - 3-mercaotoproprionate; anaerobic environment; Angiospermae; biodegradation; cores; geochemistry; Gramineae; humic acids; humic substances; marine sediments; marshes; mires; Monocotyledoneae; New York; organic acids; organic compounds; organic sulfur; particulate materials; Plantae; preservation; processes; salt marshes; sediments; Shelter Island; Spartina; Spartina alterniflora; Spermatophyta; sulfur; thiols; United States ER - TY - JOUR T1 - Imaging studies of cocaine in the human brain and studies of the cocaine addict. AN - 79165013; 9237448 JF - Annals of the New York Academy of Sciences AU - Volkow, N D AU - Wang, G J AU - Fowler, J S AD - Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1997/05/30/ PY - 1997 DA - 1997 May 30 SP - 41 EP - 54; discussion 54-5 VL - 820 SN - 0077-8923, 0077-8923 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Humans KW - Brain -- pathology KW - Brain -- drug effects KW - Opioid-Related Disorders -- pathology KW - Tomography, Emission-Computed KW - Cocaine -- toxicity KW - Cocaine -- pharmacokinetics KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79165013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Imaging+studies+of+cocaine+in+the+human+brain+and+studies+of+the+cocaine+addict.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BFowler%2C+J+S&rft.aulast=Volkow&rft.aufirst=N&rft.date=1997-05-30&rft.volume=820&rft.issue=&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-08-21 N1 - Date created - 1997-08-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position. AN - 78999639; 9144157 AB - Acyl-acyl carrier protein (ACP) desaturases introduce double bonds at specific positions in fatty acids of defined chain lengths and are one of the major determinants of the monounsaturated fatty acid composition of vegetable oils. Mutagenesis studies were conducted to determine the structural basis for the substrate and double bond positional specificities displayed by acyl-ACP desaturases. By replacement of specific amino acid residues in a Delta6-palmitoyl (16:0)-ACP desaturase with their equivalents from a Delta9-stearoyl (18:0)-ACP desaturase, mutant enzymes were identified that have altered fatty acid chain-length specificities or that can insert double bonds into either the Delta6 or Delta9 positions of 16:0- and 18:0-ACP. Most notably, by replacement of five amino acids (A181T/A200F/S205N/L206T/G207A), the Delta6-16:0-ACP desaturase was converted into an enzyme that functions principally as a Delta9-18:0-ACP desaturase. Many of the determinants of fatty acid chain-length specificity in these mutants are found in residues that line the substrate binding channel as revealed by x-ray crystallography of the Delta9-18:0-ACP desaturase. The crystallographic model of the active site is also consistent with the diverged activities associated with naturally occurring variant acyl-ACP desaturases. In addition, on the basis of the active-site model, a Delta9-18:0-ACP desaturase was converted into an enzyme with substrate preference for 16:0-ACP by replacement of two residues (L118F/P179I). These results demonstrate the ability to rationally modify acyl-ACP desaturase activities through site-directed mutagenesis and represent a first step toward the design of acyl-ACP desaturases for the production of novel monounsaturated fatty acids in transgenic oilseed crops. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Cahoon, E B AU - Lindqvist, Y AU - Schneider, G AU - Shanklin, J AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997/05/13/ PY - 1997 DA - 1997 May 13 SP - 4872 EP - 4877 VL - 94 IS - 10 SN - 0027-8424, 0027-8424 KW - DNA Primers KW - 0 KW - Plant Oils KW - Recombinant Fusion Proteins KW - Mixed Function Oxygenases KW - EC 1.- KW - acyl-(acyl-carrier-protein)desaturase KW - EC 1.14.19.2 KW - Index Medicus KW - Animals KW - Models, Molecular KW - Recombinant Fusion Proteins -- isolation & purification KW - Amino Acid Sequence KW - Recombinant Fusion Proteins -- chemistry KW - Cloning, Molecular KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Base Sequence KW - Kinetics KW - Escherichia coli KW - Molecular Sequence Data KW - Point Mutation KW - Protein Conformation KW - Mixed Function Oxygenases -- isolation & purification KW - Mixed Function Oxygenases -- chemistry KW - Mixed Function Oxygenases -- metabolism KW - Plants -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78999639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Redesign+of+soluble+fatty+acid+desaturases+from+plants+for+altered+substrate+specificity+and+double+bond+position.&rft.au=Cahoon%2C+E+B%3BLindqvist%2C+Y%3BSchneider%2C+G%3BShanklin%2C+J&rft.aulast=Cahoon&rft.aufirst=E&rft.date=1997-05-13&rft.volume=94&rft.issue=10&rft.spage=4872&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-05 N1 - Date created - 1997-06-05 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2578-82 [2006194] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2510-4 [2006187] Biochemistry. 1993 Apr 27;32(16):4349-53 [8476865] J Biol Chem. 1994 Nov 4;269(44):27519-26 [7961667] Plant Physiol. 1994 Oct;106(2):807-8 [7991701] Plant Cell. 1995 Jul;7(7):957-70 [7640528] Biochim Biophys Acta. 1993 Sep 8;1169(3):231-5 [7548115] Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8771-5 [8710947] EMBO J. 1996 Aug 15;15(16):4081-92 [8861937] J Biol Chem. 1968 Sep 10;243(17):4626-33 [4300868] Arch Biochem Biophys. 1974 May;162(1):158-65 [4831331] J Biol Chem. 1979 Aug 10;254(15):7123-8 [379000] J Biol Chem. 1982 Oct 25;257(20):12141-7 [7118934] Gene. 1989 Apr 15;77(1):51-9 [2744487] Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11184-8 [1454797] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: trial design and early clinical results. AN - 79011456; 9151231 AB - A Phase I/II clinical trial of boron neutron capture therapy (BNCT) for glioblastoma multiforme is underway using the amino acid analog p-boronophenylalanine (BPA) and the epithermal neutron beam at the Brook-haven Medical Research Reactor. Biodistribution studies were carried out in 18 patients at the time of craniotomy using an i.v. infusion of BPA, solubilized as a fructose complex (BPA-F). There were no toxic effects related to the BPA-F administration at doses of 130, 170, 210, or 250 mg BPA/kg body weight. The tumor/ blood, brain/blood and scalp/blood boron concentration ratios were approximately 3.5:1, 1:1 and 1.5:1, respectively. Ten patients have received BNCT following 2-hr infusions of 250 mg BPA/kg body weight. The average boron concentration in the blood during the irradiation was 13.0 +/- 1.5 micrograms 10B/g. The prescribed maximum dose to normal brain (1 cm3 volume) was 10.5 photon-equivalent Gy (Gy-Eq). Estimated maximum and minimum doses (mean +/- sd, n = 10) to the tumor volume were 52.6 +/- 4.9 Gy-Eq (range: 64.4-47.6) and 25.2 +/- 4.2 Gy-Eq (range: 32.3-20.0), respectively). The estimated minimum dose to the target volume (tumor +2 cm margin) was 12.3 +/- 2.7 Gy-Eq (range: 16.2-7.8). There were no adverse effects on normal brain. The scalp showed mild erythema, followed by epilation in the 8 cm diameter field. Four patients developed recurrent tumor, apparently in the lower dose (deeper) regions of the target volume, at post-BNCT intervals of 7,5,3.5 and 3 months, respectively. The remaining patients have had less than 4 months of post-BNCT follow-up. BNCT, at this starting dose level, appears safe. Plans are underway to begin the dose escalation phase of this protocol. JF - Journal of neuro-oncology AU - Coderre, J A AU - Elowitz, E H AU - Chadha, M AU - Bergland, R AU - Capala, J AU - Joel, D D AU - Liu, H B AU - Slatkin, D N AU - Chanana, A D AD - Medical Department Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997/05// PY - 1997 DA - May 1997 SP - 141 EP - 152 VL - 33 IS - 1-2 SN - 0167-594X, 0167-594X KW - Boron Compounds KW - 0 KW - Phenylalanine KW - 47E5O17Y3R KW - 4-boronophenylalanine KW - UID84303EL KW - Index Medicus KW - Neutrons KW - Magnetic Resonance Imaging KW - Humans KW - Brain -- pathology KW - Adult KW - Tissue Distribution KW - Nuclear Reactors KW - Phenylalanine -- analogs & derivatives KW - Boron Compounds -- pharmacokinetics KW - Phenylalanine -- adverse effects KW - Boron Compounds -- adverse effects KW - Glioblastoma -- radiotherapy KW - Boron Neutron Capture Therapy -- adverse effects KW - Brain Neoplasms -- surgery KW - Brain Neoplasms -- radiotherapy KW - Glioblastoma -- surgery KW - Glioblastoma -- diagnosis KW - Phenylalanine -- pharmacokinetics KW - Brain Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79011456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuro-oncology&rft.atitle=Boron+neutron+capture+therapy+for+glioblastoma+multiforme+using+p-boronophenylalanine+and+epithermal+neutrons%3A+trial+design+and+early+clinical+results.&rft.au=Coderre%2C+J+A%3BElowitz%2C+E+H%3BChadha%2C+M%3BBergland%2C+R%3BCapala%2C+J%3BJoel%2C+D+D%3BLiu%2C+H+B%3BSlatkin%2C+D+N%3BChanana%2C+A+D&rft.aulast=Coderre&rft.aufirst=J&rft.date=1997-05-01&rft.volume=33&rft.issue=1-2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuro-oncology&rft.issn=0167594X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-08-04 N1 - Date created - 1997-08-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - BLT-EC (breach, leach and transport-equilibrium chemistry) data input guide; a computer model for simulating release and coupled geochemical transport of contaminants from a subsurface disposal facility AN - 51033368; 1999-000230 AB - The BLT-EC computer code has been developed, implemented, and tested. BLT-EC is a two-dimensional finite element computer code capable of simulating the time-dependent release and reactive transport of aqueous phase species in a subsurface soil system. BLT-EC contains models to simulate the processes (container degradation, waste-form performance, transport, chemical reactions, and radioactive production and decay) most relevant to estimating the release and transport of contaminants from a subsurface disposal system. Water flow is provided through tabular input or auxiliary files. Container degradation considers localized failure due to putting corrosion and general failure due to uniform surface degradation processes. Waste-form performance considers release to be limited by one of four mechanisms; rinse with partitioning, diffusion, uniform surface degradation, and solubility. Transport considers the processes of advection, dispersion, diffusion, chemical reaction, radioactive production and decay, and sources (waste form releases). Chemical reactions accounted for include complexation, sorption, dissolution-precipitation, oxidation reduction, and ion exchange. Radioactive production and decay in the waste form is simulated. To improve the usefulness of BLT-EC, a pre-processor, ECIN, which assists in the creation of chemistry input files, and post-processor, BLTPLOT, which provides a visual display of the data have been developed, BLT-EC also includes an extensive database of thermodynamic data that is also accessible to ECIN. This document reviews the models implemented in BLT-EC and serves as a guide to creating input files and applying BLT-EC. JF - NUREG/CR (United States. Nuclear Regulatory Commission) AU - MacKinnon, R J AU - Sullivan, T M AU - Kinsey, R R Y1 - 1997/05// PY - 1997 DA - May 1997 SP - 364 PB - U. S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, Washington, DC SN - 0278-1670, 0278-1670 KW - sorption KW - dispersivity KW - degradation KW - isotopes KW - complexing KW - data processing KW - radioactive waste KW - waste management KW - finite element analysis KW - radioactive isotopes KW - chemical reactions KW - transport KW - BLT-EC model KW - ion exchange KW - thermodynamic properties KW - diffusion KW - statistical analysis KW - mathematical models KW - migration of elements KW - two-dimensional models KW - computer programs KW - waste disposal KW - leaching KW - low-level waste KW - underground disposal KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51033368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=MacKinnon%2C+R+J%3BSullivan%2C+T+M%3BKinsey%2C+R+R&rft.aulast=MacKinnon&rft.aufirst=R&rft.date=1997-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=BLT-EC+%28breach%2C+leach+and+transport-equilibrium+chemistry%29+data+input+guide%3B+a+computer+model+for+simulating+release+and+coupled+geochemical+transport+of+contaminants+from+a+subsurface+disposal+facility&rft.title=BLT-EC+%28breach%2C+leach+and+transport-equilibrium+chemistry%29+data+input+guide%3B+a+computer+model+for+simulating+release+and+coupled+geochemical+transport+of+contaminants+from+a+subsurface+disposal+facility&rft.issn=02781670&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1999-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number NUREG/CR-6515NEG, Springfield, VA, United States N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - BLT-EC model; chemical reactions; complexing; computer programs; data processing; degradation; diffusion; dispersivity; finite element analysis; ion exchange; isotopes; leaching; low-level waste; mathematical models; migration of elements; radioactive isotopes; radioactive waste; sorption; statistical analysis; thermodynamic properties; transport; two-dimensional models; underground disposal; waste disposal; waste management ER - TY - JOUR T1 - Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. AN - 79000110; 9126741 AB - Cocaine blocks the reuptake of dopamine, a neurotransmitter involved in the control of movement, cognition, motivation and reward. This leads to an increase in extracellular dopamine; the reinforcing effect of cocaine is associated with elevated dopamine levels in the nucleus accumbens. But addiction to cocaine involves other effects, such as craving, loss of control and compulsive drug intake; the role of the dopamine system in these effects is less well-understood. We therefore used positron emission tomography (PET) to compare the responses of cocaine addicts and normal controls to intravenous methylphenidate, a drug that, like cocaine, causes an increase in synaptic dopamine. Addicts showed reduced dopamine release in the striatum, the brain region where the nucleus accumbens is located, and also had a reduced 'high' relative to controls. In contrast, addicts showed an increased response to methylphenidate in the thalamus (a region that conveys sensory input to the cortex). This thalamic response was associated with cocaine craving and was not seen in control subjects. Thus, our findings challenge the notion that addiction involves an enhanced striatal dopamine response to cocaine and/or an enhanced induction of euphoria. Moreover, they suggest a participation of thalamic dopamine pathways in cocaine addiction, a possibility that merits further investigation. JF - Nature AU - Volkow, N D AU - Wang, G J AU - Fowler, J S AU - Logan, J AU - Gatley, S J AU - Hitzemann, R AU - Chen, A D AU - Dewey, S L AU - Pappas, N AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 1997/04/24/ PY - 1997 DA - 1997 Apr 24 SP - 830 EP - 833 VL - 386 IS - 6627 SN - 0028-0836, 0028-0836 KW - Dopamine Antagonists KW - 0 KW - Dopamine Uptake Inhibitors KW - Salicylamides KW - Methylphenidate KW - 207ZZ9QZ49 KW - Raclopride KW - 430K3SOZ7G KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Thalamus -- metabolism KW - Dopamine Antagonists -- metabolism KW - Behavior, Addictive KW - Methylphenidate -- pharmacology KW - Humans KW - Salicylamides -- metabolism KW - Adult KW - Tomography, Emission-Computed KW - Thalamus -- drug effects KW - Self-Assessment KW - Male KW - Corpus Striatum -- metabolism KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- psychology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79000110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Decreased+striatal+dopaminergic+responsiveness+in+detoxified+cocaine-dependent+subjects.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BFowler%2C+J+S%3BLogan%2C+J%3BGatley%2C+S+J%3BHitzemann%2C+R%3BChen%2C+A+D%3BDewey%2C+S+L%3BPappas%2C+N&rft.aulast=Volkow&rft.aufirst=N&rft.date=1997-04-24&rft.volume=386&rft.issue=6627&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-22 N1 - Date created - 1997-05-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Relationship between subjective effects of cocaine and dopamine transporter occupancy. AN - 78996339; 9126740 AB - Cocaine is believed to work by blocking the dopamine transporter (DAT) and thereby increasing the availability of free dopamine within the brain. Although this concept is central to current cocaine research and to treatment development, a direct relationship between DAT blockade and the subjective effects of cocaine has not been demonstrated in humans. We have used positron emission tomography to determine what level of DAT occupancy is required to produce a subjective 'high' in human volunteers who regularly abuse cocaine. We report here that intravenous cocaine at doses commonly abused by humans (0.3-0.6 mg kg(-1)) blocked between 60 and 77% of DAT sites in these subjects. The magnitude of the self-reported high was correlated with the degree of DAT occupancy, and at least 47% of the transporters had to be blocked for subjects to perceive cocaine's effects. Furthermore, the time course for the high paralleled that of cocaine concentration within the striatum, a brain region implicated in the control of motivation and reward. This is the first demonstration in humans that the doses used by cocaine abusers lead to significant blockade of DAT, and that this blockade is associated with the subjective effects of cocaine. Although these findings provide justification to target the DAT for medication development they suggest that for drugs to be effective in blocking cocaine's effects they would have to be given at doses that achieve almost complete DAT occupancy. JF - Nature AU - Volkow, N D AU - Wang, G J AU - Fischman, M W AU - Foltin, R W AU - Fowler, J S AU - Abumrad, N N AU - Vitkun, S AU - Logan, J AU - Gatley, S J AU - Pappas, N AU - Hitzemann, R AU - Shea, C E AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1997/04/24/ PY - 1997 DA - 1997 Apr 24 SP - 827 EP - 830 VL - 386 IS - 6627 SN - 0028-0836, 0028-0836 KW - Carrier Proteins KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Dopamine Uptake Inhibitors KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - SLC6A3 protein, human KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Corpus Striatum -- metabolism KW - Humans KW - Self-Assessment KW - Substance-Related Disorders -- psychology KW - Cerebellum -- metabolism KW - Cerebellum -- drug effects KW - Adult KW - Binding, Competitive KW - Tomography, Emission-Computed KW - Corpus Striatum -- drug effects KW - Substance-Related Disorders -- metabolism KW - Substance Abuse, Intravenous -- metabolism KW - Female KW - Male KW - Substance Abuse, Intravenous -- psychology KW - Carrier Proteins -- metabolism KW - Cocaine -- pharmacokinetics KW - Dopamine Uptake Inhibitors -- pharmacokinetics KW - Cocaine -- pharmacology KW - Cocaine -- metabolism KW - Dopamine Uptake Inhibitors -- metabolism KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78996339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Relationship+between+subjective+effects+of+cocaine+and+dopamine+transporter+occupancy.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BFischman%2C+M+W%3BFoltin%2C+R+W%3BFowler%2C+J+S%3BAbumrad%2C+N+N%3BVitkun%2C+S%3BLogan%2C+J%3BGatley%2C+S+J%3BPappas%2C+N%3BHitzemann%2C+R%3BShea%2C+C+E&rft.aulast=Volkow&rft.aufirst=N&rft.date=1997-04-24&rft.volume=386&rft.issue=6627&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-22 N1 - Date created - 1997-05-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Elemental analysis of contaminated sediments from harbor of NY/NJ and Hamburg using synchrotron radiation-induced X-ray emission (SRIXE) AN - 52600713; 1998-038546 JF - Eos, Transactions, American Geophysical Union AU - Jones, K W AU - Song, S R AU - Klein, R C AU - Shea-McCarthy, G AU - Anonymous Y1 - 1997/04// PY - 1997 DA - April 1997 SP - 326 PB - American Geophysical Union, Washington, DC VL - 78 IS - 17, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - concentration KW - chemical elements KW - New York County New York KW - harbors KW - pollution KW - Europe KW - Hamburg Germany KW - X-ray spectra KW - emission spectra KW - synchrotron radiation KW - SRIXE KW - New York KW - Hudson County New Jersey KW - metals KW - Central Europe KW - sediments KW - spectra KW - New Jersey KW - Germany KW - estuarine environment KW - geochemistry KW - dredged samples KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52600713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Elemental+analysis+of+contaminated+sediments+from+harbor+of+NY%2FNJ+and+Hamburg+using+synchrotron+radiation-induced+X-ray+emission+%28SRIXE%29&rft.au=Jones%2C+K+W%3BSong%2C+S+R%3BKlein%2C+R+C%3BShea-McCarthy%2C+G%3BAnonymous&rft.aulast=Jones&rft.aufirst=K&rft.date=1997-04-01&rft.volume=78&rft.issue=17%2C+Suppl.&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1997 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Central Europe; chemical elements; concentration; dredged samples; emission spectra; estuarine environment; Europe; geochemistry; Germany; Hamburg Germany; harbors; Hudson County New Jersey; metals; New Jersey; New York; New York County New York; pollution; sediments; spectra; SRIXE; synchrotron radiation; United States; X-ray spectra ER - TY - JOUR T1 - Synchrotron X-ray computed microtomography (CMT) studies of vesiculated basaltic rocks AN - 52600627; 1998-038545 JF - Eos, Transactions, American Geophysical Union AU - Song, S R AU - Jones, K W AU - Lindquist, W B AU - Dowd, B A AU - Sahagian, D L AU - Anonymous Y1 - 1997/04// PY - 1997 DA - April 1997 SP - 326 PB - American Geophysical Union, Washington, DC VL - 78 IS - 17, Suppl. SN - 0096-3941, 0096-3941 KW - vesicular texture KW - tomography KW - experimental studies KW - volcanic rocks KW - textures KW - igneous rocks KW - statistical analysis KW - new methods KW - synchrotron radiation KW - X-ray data KW - basalts KW - CMT method KW - microtomography KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52600627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Synchrotron+X-ray+computed+microtomography+%28CMT%29+studies+of+vesiculated+basaltic+rocks&rft.au=Song%2C+S+R%3BJones%2C+K+W%3BLindquist%2C+W+B%3BDowd%2C+B+A%3BSahagian%2C+D+L%3BAnonymous&rft.aulast=Song&rft.aufirst=S&rft.date=1997-04-01&rft.volume=78&rft.issue=17%2C+Suppl.&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1997 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 1 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - basalts; CMT method; experimental studies; igneous rocks; microtomography; new methods; statistical analysis; synchrotron radiation; textures; tomography; vesicular texture; volcanic rocks; X-ray data ER - TY - JOUR T1 - Photochemical production of low-molecular-weight carbonyl compounds in seawater and surface microlayer and their air-sea exchange AN - 52722418; 1997-036993 AB - Coastal and oceanic surface microlayer samples were collected using a stainless steel screen, along with subsurface bulk seawater, and were analyzed for low-molecular-weight (LMW) carbonyl compounds, including formaldehyde, acetaldehyde, propanal, glyoxal, methylglyoxal, glyoxylic acid and pyruvic acid. The enrichment factor in surface microlayer compared to corresponding subsurface seawater ranged from 1.2 to 21. A time-series measurement at a coastal site showed strong diurnal variations in concentrations of the LMW carbonyl compounds in the surface microlayer and in the enrichment factor, with maxima in the early afternoon and minima in the early morning. Exposure of samples to sunlight resulted in the higher yields of these compounds in the surface microlayer than in the bulk seawater, by a factor of 1.1-25, suggesting that the higher photoproduction rate of LMW carbonyl compounds in the surface microlayer accounts for the majority of the observed enrichment in these samples. Potential sinks include biological uptake and mixing. Air-sea exchange may be a source for soluble compounds and a sink for less soluble compounds. The enrichment of the LMW carbonyl in surface microlayer may alter their net air-sea exchange direction, e.g., from the ocean as a potential sink to a source for atmospheric acetaldehyde and acetone. The residence times of the LMW carbonyl compounds in the microlayer were estimated to be on the order of tens of seconds to minutes using a modified two-layer model. However, to maintain the observed microlayer enrichment factor, the residence time should be on the order of approximately 1 hour. This prolonged residence time may be due to organic enrichment in the surface microlayer ("organic film") which inhibited molecular transfer of carbonyl compounds into and out of the microlayer. The deviated behavior from model prediction may also be due to changes in the apparent partition coefficients of these species as a result of their physical and chemical interactions with organic matrix in the surface microlayer. JF - Marine Chemistry AU - Zhou, Xianliang AU - Mopper, Kenneth A2 - Sharp, Jonathan H. A2 - Yoshinari, Tadashi Y1 - 1997/03// PY - 1997 DA - March 1997 SP - 201 EP - 213 PB - Elsevier, Amsterdam VL - 56 IS - 3-4 SN - 0304-4203, 0304-4203 KW - photosynthesis KW - sea water KW - Sargasso Sea KW - enrichment KW - photochemistry KW - rates KW - air-sea interface KW - hydrochemistry KW - chemical reactions KW - carbonyl groups KW - time factor KW - marine environment KW - diurnal variations KW - North Atlantic KW - geochemistry KW - Atlantic Ocean KW - productivity KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52722418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Chemistry&rft.atitle=Photochemical+production+of+low-molecular-weight+carbonyl+compounds+in+seawater+and+surface+microlayer+and+their+air-sea+exchange&rft.au=Zhou%2C+Xianliang%3BMopper%2C+Kenneth&rft.aulast=Zhou&rft.aufirst=Xianliang&rft.date=1997-03-01&rft.volume=56&rft.issue=3-4&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Marine+Chemistry&rft.issn=03044203&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/03044203 LA - English DB - GeoRef N1 - Conference title - Modern chemical and biological oceanography; the influence of Peter J. Wangersky N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 1997-01-01 N1 - Number of references - 32 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - MRCHBD N1 - SubjectsTermNotLitGenreText - air-sea interface; Atlantic Ocean; carbonyl groups; chemical reactions; diurnal variations; enrichment; geochemistry; hydrochemistry; marine environment; North Atlantic; photochemistry; photosynthesis; productivity; rates; Sargasso Sea; sea water; time factor ER - TY - JOUR T1 - Single-and dual-energy CT with monochromatic synchrotron x-rays. AN - 85259530; pmid-9044419 AB - We explored the potential for clinical research of computed tomography (CT) with monochromatic x-rays using the preclinical multiple energy computed tomography (MECT) system at the National Synchrotron Light Source. MECT has a fixed, horizontal fan beam with a subject apparatus rotating about a vertical axis; it will be used for imaging the human head and neck. Two CdWO4-photodiode array detectors with different spatial resolutions were used. A 10.5 cm diameter acrylic phantom was imaged with MECT at 43 keV and with a conventional CT (CCT) at 80 kVp: spatial resolution approximately equal to 6.5 line pairs (lp)/cm for both; slice height, 2.6 mm for MECT against 3.0 mm for CCT; surface dose, 3.1 cGy for MECT against 2.0 cGy for CCT. The resultant image noise was 1.5 HU for MECT against 3 HU for CCT. Computer simulations of the same images with more precisely matched spatial resolution, slice height and dose indicated an image-noise ratio of 1.4:1.0 for CCT against MECT. A 13.5 cm diameter acrylic phantom imaged with MECT at approximately 0.1 keV above the iodine K edge and with CCT showed, for a 240 micrograms I ml-1 solution, an image contrast of 26 HU for MECT and 13 and 9 HU for the 80 and 100 kVp CCT, respectively. The corresponding numbers from computer simulation of the same images were 26, 12, and 9 HU, respectively. MECT's potential for use in clinical research is discussed. JF - Physics in Medicine and Biology AU - Dilmanian, F A AU - Wu, X Y AU - Parsons, E C AU - Ren, B AU - Kress, J AU - Button, T M AU - Chapman, L D AU - Coderre, J A AU - Giron, F AU - Greenberg, D AU - Krus, D J AU - Liang, Z AU - Marcovici, S AU - Petersen, M J AU - Roque, C T AU - Shleifer, M AU - Slatkin, D N AU - Thomlinson, W C AU - Yamamoto, K AU - Zhong, Z AD - Brookhaven National Laboratory, Upton, NY 11973-5000, USA. PY - 1997 SP - 371 EP - 387 VL - 42 IS - 2 SN - 0031-9155, 0031-9155 KW - Computer Simulation KW - Head KW - Synchrotrons KW - Human KW - Tomography, X-Ray Computed KW - Animal KW - Rabbits KW - Neck KW - Acrylates KW - X-Rays KW - Equipment Design KW - Comparative Study KW - Support, U.S. Gov't, Non-P.H.S. KW - Iodine KW - Phantoms, Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85259530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+in+Medicine+and+Biology&rft.atitle=Single-and+dual-energy+CT+with+monochromatic+synchrotron+x-rays.&rft.au=Dilmanian%2C+F+A%3BWu%2C+X+Y%3BParsons%2C+E+C%3BRen%2C+B%3BKress%2C+J%3BButton%2C+T+M%3BChapman%2C+L+D%3BCoderre%2C+J+A%3BGiron%2C+F%3BGreenberg%2C+D%3BKrus%2C+D+J%3BLiang%2C+Z%3BMarcovici%2C+S%3BPetersen%2C+M+J%3BRoque%2C+C+T%3BShleifer%2C+M%3BSlatkin%2C+D+N%3BThomlinson%2C+W+C%3BYamamoto%2C+K%3BZhong%2C+Z&rft.aulast=Dilmanian&rft.aufirst=F&rft.date=1997-02-01&rft.volume=42&rft.issue=2&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Physics+in+Medicine+and+Biology&rft.issn=00319155&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Dopamine D2 receptor availability in opiate-dependent subjects before and after naloxone-precipitated withdrawal. AN - 78805812; 9015800 AB - Dopamine may play a role in opiate withdrawal and dependence. We measured dopamine D2 receptor availability in 11 opiate-dependent subjects using PFT and [11C]raclopride at baseline and during naloxone-precipitated withdrawal. Because [11C]raclopride is sensitive to endogenous dopamine, this strategy enabled us to test whether we could document in humans the DA reductions reported in animal models of opiate withdrawal. Results were compared with values from 11 controls, two of which also received naloxone. The ratio of the distribution volume in striatum to that in cerebellum (Bmax/Kd + 1) was used as model parameter for D2 receptor availability. Baseline measures for Bmax/Kd were lower in opiate-dependent subjects (2.44 +/- 0.4) than in controls (2.97 +/- 0.45 P < or = .009). Naloxone precipitated an intense withdrawal in the abusers but did not change the Bmax/Kd ratio. This study documents decreases in D2 receptors in opiate-dependent subjects but does not document significant changes in striatal DA concentration during acute withdrawal. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Wang, G J AU - Volkow, N D AU - Fowler, J S AU - Logan, J AU - Abumrad, N N AU - Hitzemann, R J AU - Pappas, N S AU - Pascani, K AD - Department of Medicine, Brookhaven National Laboratory, Upton, NY, USA. Y1 - 1997/02// PY - 1997 DA - February 1997 SP - 174 EP - 182 VL - 16 IS - 2 SN - 0893-133X, 0893-133X KW - Narcotics KW - 0 KW - Receptors, Dopamine D2 KW - Naloxone KW - 36B82AMQ7N KW - Index Medicus KW - Humans KW - Adult KW - Tomography, Emission-Computed KW - Middle Aged KW - Basal Ganglia -- diagnostic imaging KW - Male KW - Naloxone -- pharmacology KW - Substance Withdrawal Syndrome -- psychology KW - Substance-Related Disorders -- metabolism KW - Narcotics -- pharmacology KW - Receptors, Dopamine D2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78805812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Dopamine+D2+receptor+availability+in+opiate-dependent+subjects+before+and+after+naloxone-precipitated+withdrawal.&rft.au=Wang%2C+G+J%3BVolkow%2C+N+D%3BFowler%2C+J+S%3BLogan%2C+J%3BAbumrad%2C+N+N%3BHitzemann%2C+R+J%3BPappas%2C+N+S%3BPascani%2C+K&rft.aulast=Wang&rft.aufirst=G&rft.date=1997-02-01&rft.volume=16&rft.issue=2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-15 N1 - Date created - 1997-04-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Study of chemical state of toxic metals during the life cycle of fly ash using X-ray absorption near-edge structure AN - 52692877; 1997-059414 JF - X-Ray Spectrometry AU - Osan, Janos AU - Torok, Balazs AU - Torok, Szabina AU - Jones, Keith W Y1 - 1997/02// PY - 1997 DA - February 1997 SP - 37 EP - 44 PB - Wiley, Chichester VL - 26 IS - 1 SN - 0049-8246, 0049-8246 KW - toxic materials KW - landfills KW - arsenic KW - pollution KW - X-ray spectra KW - XANES spectra KW - ash KW - toxicity KW - metals KW - X-ray analysis KW - spectra KW - waste disposal KW - fluvial environment KW - chromium KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52692877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=X-Ray+Spectrometry&rft.atitle=Study+of+chemical+state+of+toxic+metals+during+the+life+cycle+of+fly+ash+using+X-ray+absorption+near-edge+structure&rft.au=Osan%2C+Janos%3BTorok%2C+Balazs%3BTorok%2C+Szabina%3BJones%2C+Keith+W&rft.aulast=Osan&rft.aufirst=Janos&rft.date=1997-02-01&rft.volume=26&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=X-Ray+Spectrometry&rft.issn=00498246&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 20 N1 - Document feature - illus. incl. 2 tables N1 - SuppNotes - Pittcon issue N1 - Last updated - 2012-06-07 N1 - CODEN - XRSPAX N1 - SubjectsTermNotLitGenreText - arsenic; ash; chromium; fluvial environment; landfills; metals; pollution; spectra; toxic materials; toxicity; waste disposal; X-ray analysis; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. AN - 78786665; 8960062 AB - Although increases in dopamine secondary to the inhibition of the dopamine transporter appear to underlie the reinforcing properties of cocaine, there is presently no model that relates the elevation of synaptic dopamine to the transporter occupancy by cocaine. We propose such a model based on positron emission tomographic (PET) measurements of the brain concentration of cocaine and the assumption of rapid equilibrium between free cocaine and cocaine bound to the dopamine transporter. A euphorigenic dose of cocaine (about 40 mg) is predicted to occupy 80-90% of the transporters, while a perceptible dose (about 5 mg) occupies about 40% of the transporters. If reuptake of dopamine is reduced in proportion to the fraction of transporters occupied by cocaine, our model indicates that synaptic dopamine rises supra-linearly with occupancy, so that 5 and 40 mg doses of cocaine give about 2- and 10-fold increases, respectively. A consequence is that a given dose of cocaine produces a similar degree of elevation of dopamine regardless of the prior level of occupation of the transporters by cocaine. This prediction is supported by recent PET/neuropsychological studies in our laboratory where dopamine transporter occupancy was measured after giving methylphenidate intravenously to volunteers; similarly intense "highs" were reported whether the initial occupancy was zero or 75-85%. It could also explain why attempts to block the psychostimulant-induced "high" by pretreating subjects with drugs that block the dopamine transporter have been unsuccessful, and why the use of methylphenidate to treat cocaine addicts led to increased cocaine consumption. JF - Biochemical pharmacology AU - Gatley, S J AU - Volkow, N D AU - Gifford, A N AU - Ding, Y S AU - Logan, J AU - Wang, G J AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997/01/10/ PY - 1997 DA - 1997 Jan 10 SP - 43 EP - 52 VL - 53 IS - 1 SN - 0006-2952, 0006-2952 KW - Carbon Radioisotopes KW - 0 KW - Carrier Proteins KW - Dopamine Plasma Membrane Transport Proteins KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Methylphenidate KW - 207ZZ9QZ49 KW - 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane KW - 4H1Z7121WS KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Papio KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Substance-Related Disorders KW - Tomography, Emission-Computed KW - Methylphenidate -- metabolism KW - Cocaine -- analogs & derivatives KW - Carrier Proteins -- metabolism KW - Dopamine -- metabolism KW - Cocaine -- metabolism KW - Synapses -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78786665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Model+for+estimating+dopamine+transporter+occupancy+and+subsequent+increases+in+synaptic+dopamine+using+positron+emission+tomography+and+carbon-11-labeled+cocaine.&rft.au=Gatley%2C+S+J%3BVolkow%2C+N+D%3BGifford%2C+A+N%3BDing%2C+Y+S%3BLogan%2C+J%3BWang%2C+G+J&rft.aulast=Gatley&rft.aufirst=S&rft.date=1997-01-10&rft.volume=53&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-09 N1 - Date created - 1997-01-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cloning and expression of pneumococcal genes in Streptococcus pneumoniae. AN - 79532228; 9442484 AB - An overview of gene cloning in Streptococcus pneumoniae is presented. The advantages of such cloning, especially for pneumococcal genes, are enumerated. The molecular fate of DNA in transformation of S. pneumoniae, in particular, the conversion of DNA to single-strand segments on entry, determines the mechanisms for plasmid establishment and interaction with the chromosome. One of these mechanisms, the chromosomal facilitation of plasmid establishment, is useful for obtaining recombinant plasmids and for introducing an allele from the chromosome into a plasmid. The difference between linear and circular synapsis of donor DNA strands with the chromosome is illustrated. Circular synapsis can give rise to circular integration, which is useful for insertional mutagenesis of chromosomal genes, for coupled cloning in Escherichia coli, and for sequential cloning of DNA along the pneumococcal chromosome. Cloning in S. pneumoniae is not notably affected by DNA mismatch repair or restriction systems in the host cell. Unusual features of gene expression in S. pneumoniae are discussed. Transcription begins most often at promoters with extended -10 sequences, and in a small but significant number of cases, translation does not require a ribosome-binding site with a Shine-Dalgarno sequence. JF - Microbial drug resistance (Larchmont, N.Y.) AU - Lacks, S A AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 327 EP - 337 VL - 3 IS - 4 SN - 1076-6294, 1076-6294 KW - Index Medicus KW - Animals KW - Plasmids -- genetics KW - Humans KW - Cloning, Molecular KW - Gene Expression Regulation, Bacterial -- physiology KW - Genes, Bacterial -- genetics KW - Gene Expression Regulation, Bacterial -- genetics KW - Streptococcus pneumoniae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79532228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+drug+resistance+%28Larchmont%2C+N.Y.%29&rft.atitle=Cloning+and+expression+of+pneumococcal+genes+in+Streptococcus+pneumoniae.&rft.au=Lacks%2C+S+A&rft.aulast=Lacks&rft.aufirst=S&rft.date=1997-01-01&rft.volume=3&rft.issue=4&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Microbial+drug+resistance+%28Larchmont%2C+N.Y.%29&rft.issn=10766294&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-12 N1 - Date created - 1998-03-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cocaine abusers do not show loss of dopamine transporters with age. AN - 79303071; 9307051 AB - Cocaine blocks dopamine transporters (DAT) and this effect is crucial to its reinforcing properties. To assess the effects of chronic cocaine on DAT we evaluated 20 current cocaine abusers and 20 age matched controls using PET and [C-11]cocaine as a DAT ligand. Though there were no differences in DAT availability between groups, current cocaine abusers (and 12 detoxified cocaine abusers studied previously) did not show the typical age-related decline in DAT seen in controls. Though further studies are required to rule out sampling effects and to control for confounding variables (i.e. smoking), one could speculate that chronic DAT blockade by cocaine has a protective effect on the loss of DAT with age. JF - Life sciences AU - Wang, G J AU - Volkow, N D AU - Fowler, J S AU - Fischman, M AU - Foltin, R AU - Abumrad, N N AU - Logan, J AU - Pappas, N R AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 1059 EP - 1065 VL - 61 IS - 11 SN - 0024-3205, 0024-3205 KW - Carrier Proteins KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - SLC6A3 protein, human KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Smoking KW - Humans KW - Corpus Striatum -- metabolism KW - Adult KW - Male KW - Female KW - Cerebellum -- metabolism KW - Blood-Brain Barrier KW - Carrier Proteins -- metabolism KW - Aging KW - Substance-Related Disorders -- metabolism KW - Cocaine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79303071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Cocaine+abusers+do+not+show+loss+of+dopamine+transporters+with+age.&rft.au=Wang%2C+G+J%3BVolkow%2C+N+D%3BFowler%2C+J+S%3BFischman%2C+M%3BFoltin%2C+R%3BAbumrad%2C+N+N%3BLogan%2C+J%3BPappas%2C+N+R&rft.aulast=Wang&rft.aufirst=G&rft.date=1997-01-01&rft.volume=61&rft.issue=11&rft.spage=1059&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-15 N1 - Date created - 1997-10-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Evidence for an uncommon microsatellite instability on mouse chromosomes 2 and 4 and its possible role in radiation leukemogenesis. AN - 79127331; 9215755 AB - Although microsatellite instability (MSI), usually detected by DNA length polymorphisms, has been implicated in the induction of solid tumors in both humans and animals, its role in leukemogenesis is unclear. The goal of this study was to investigate whether there is an association between MSI and radiation leukemogenesis in CBA/Ca mice. Microsatellite lengths at 55 loci, mapped to eight different mouse chromosomes, were examined in two groups of DNA samples: 1) 10 normal DNA samples collected from the bone marrow cells of control male CBA/Ca mice, and 2) 17 DNA samples isolated from the spleens of mice that developed myeloid leukemia (ML) after exposure to neutrons, or X rays, or gamma rays. Microsatellite markers were amplified using the non-radioisotopic multiplex-touchdown PCR protocols developed in our laboratory, and the sizes of amplicons were examined on 6% non-denaturing polyacrylamide gels. Although no correlation between microsatellite length polymorphisms and radiation leukemogenesis was observed at the 55 CBA/Ca mouse loci tested in this study, an uncommon MSI, manifested as the absence of DNA bands after PCR amplification at 2 loci (D2MIT140 and D4MIT104), was observed in both control and ML samples. However, the frequency of ML samples showing this type of MSI is statistically significant (p<0.05). Although there is no direct evidence that this type of MSI predisposes mice to the development of leukemia, the results suggests that genes flanking the D2MIT140 and D4MIT104 are susceptible to spontaneous mutation and perhaps to damage caused by ionizing radiation. JF - Blood cells, molecules & diseases AU - Rithidech, K N AU - Dunn, J J AU - Gordon, C R AU - Cronkite, E P AU - Bond, V P AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. rithidech@bnlarm.bnl.gov Y1 - 1997 PY - 1997 DA - 1997 SP - 99 EP - 109 VL - 23 IS - 1 SN - 1079-9796, 1079-9796 KW - Index Medicus KW - Polymerase Chain Reaction KW - Animals KW - Mice, Inbred CBA KW - Mice KW - Male KW - Microsatellite Repeats KW - Leukemia, Radiation-Induced -- genetics KW - Chromosomes -- chemistry KW - Leukemia, Experimental -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79127331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood+cells%2C+molecules+%26+diseases&rft.atitle=Evidence+for+an+uncommon+microsatellite+instability+on+mouse+chromosomes+2+and+4+and+its+possible+role+in+radiation+leukemogenesis.&rft.au=Rithidech%2C+K+N%3BDunn%2C+J+J%3BGordon%2C+C+R%3BCronkite%2C+E+P%3BBond%2C+V+P&rft.aulast=Rithidech&rft.aufirst=K&rft.date=1997-01-01&rft.volume=23&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Blood+cells%2C+molecules+%26+diseases&rft.issn=10799796&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-03 N1 - Date created - 1997-10-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Northeast Waste Management Enterprise (NEWME) 1996 annual/final report AN - 52540757; 1999-000184 AB - The Northeast Waste Management Enterprise was created in response to Dr. Clyde Frank's vision of a new partnership between research, industrial, and financial sectors, with the goal of speeding development and use (particularly at U.S. Department of Energy (DOE) facilities) of environmental remediation technologies. It was anticipated that this partnership would also strengthen the international competitiveness of the U.S. environmental industry. Brookhaven National Laboratory's (BNL) response to Dr. Frank was a proposal to create the Northeast Waste Management Alliance, later renamed the Northeast Waste Management Enterprise (NEWME). Recognizing the need to supplement its own technical expertise with acumen in business, financial management, and venture capital development, BNL joined forces with the Long Island Research Institute (LIRI). Since its inception at the end of FY 1993, NEWME has achieved several significant accomplishments in pursuing its original business and strategic plans. However, its successes have been constrained by a fundamental mismatch between the time scales required for technology commercialization, and the immediate need for available environmental technologies of those involved with ongoing environmental remediations at DOE facilities. JF - BNL (Brookhaven National Laboratory) AU - Goland, A AU - Kaplan, E AU - Palmedo, P Y1 - 1997 PY - 1997 DA - 1997 SP - 130 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - soils KW - U. S. Department of Energy KW - government agencies KW - soil treatment KW - pollution KW - remediation KW - waste management KW - financing KW - decontamination KW - metals KW - uranium KW - actinides KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52540757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Goland%2C+A%3BKaplan%2C+E%3BPalmedo%2C+P&rft.aulast=Goland&rft.aufirst=A&rft.date=1997-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Northeast+Waste+Management+Enterprise+%28NEWME%29+1996+annual%2Ffinal+report&rft.title=Northeast+Waste+Management+Enterprise+%28NEWME%29+1996+annual%2Ffinal+report&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1999-01-01 N1 - Availability - National Technical Information Service, Springfield, VA, United States N1 - PubXState - NY N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - actinides; decontamination; financing; government agencies; metals; pollution; remediation; soil treatment; soils; U. S. Department of Energy; uranium; waste management ER - TY - JOUR T1 - Simultaneous mooring-based measurements of seawater CO (sub 2) and O (sub 2) off Cape Hatteras, North Carolina AN - 52537669; 1999-003392 AB - We deployed CO (sub 2) and O (sub 2) sensors on the U.S. continental shelf off Cape Hatteras, North Carolina, during late summer 1994. A continuous 32-d gas record was obtained at 20 m in 25 m of water, below the thermocline for most of the period. Analysis of the correlation between CO (sub 2) and O (sub 2) indicates that biological and advective processes dominated the gas variability, with small or insignificant fluxes due to air-sea exchange, vertical eddy diffusion, and carbonate dissolution or formation. The observed O (sub 2) :CO (sub 2) correlation was 1.39, within the range predicted for the photosynthetic quotient. Photosynthesis and respiration appeared to be tightly coupled, resulting in no net community production in these waters during the late summer. It is evident from these results that the combination of mooring-based CO (sub 2) and O (sub 2) measurements will be a powerful tool for studying the marine carbon cycle. JF - Limnology and Oceanography AU - DeGrandpre, M D AU - Hammar, T R AU - Wallace, D W R AU - Wirick, C D Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 21 EP - 28 PB - American Society of Limnology and Oceanography, Ann Arbor, MI VL - 42 IS - 1 SN - 0024-3590, 0024-3590 KW - United States KW - respiration KW - photosynthesis KW - Cape Hatteras KW - sea water KW - oxygen KW - Dare County North Carolina KW - air-sea interface KW - salinity KW - solution KW - carbon dioxide KW - circulation KW - carbon KW - geochemistry KW - Atlantic Coastal Plain KW - Northwest Atlantic KW - time series analysis KW - biochemistry KW - statistical analysis KW - photochemistry KW - geochemical cycle KW - biogenic processes KW - stratification KW - marine environment KW - eddies KW - North Carolina KW - continental shelf KW - carbon cycle KW - North Atlantic KW - carbonates KW - Atlantic Ocean KW - 07:Oceanography KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52537669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Simultaneous+mooring-based+measurements+of+seawater+CO+%28sub+2%29+and+O+%28sub+2%29+off+Cape+Hatteras%2C+North+Carolina&rft.au=DeGrandpre%2C+M+D%3BHammar%2C+T+R%3BWallace%2C+D+W+R%3BWirick%2C+C+D&rft.aulast=DeGrandpre&rft.aufirst=M&rft.date=1997-01-01&rft.volume=42&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/ L2 - http://aslo.org/lo/toc/index.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 33 N1 - PubXState - MI N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - LIOCAH N1 - SubjectsTermNotLitGenreText - air-sea interface; Atlantic Coastal Plain; Atlantic Ocean; biochemistry; biogenic processes; Cape Hatteras; carbon; carbon cycle; carbon dioxide; carbonates; circulation; continental shelf; Dare County North Carolina; eddies; geochemical cycle; geochemistry; marine environment; North Atlantic; North Carolina; Northwest Atlantic; oxygen; photochemistry; photosynthesis; respiration; salinity; sea water; solution; statistical analysis; stratification; time series analysis; United States ER - TY - JOUR T1 - Infrared synchrotron microspectrometry; applications to microanalysis in the micron scale range AN - 52380764; 2000-023213 JF - Proceedings of the ... European Current Research on Fluid Inclusions (ECROFI) AU - Guilhoumou, Nicole AU - Dumas, Paul AU - Carr, G Larry AU - Williams, Gwyn Philipp A2 - Boiron, Marie-Christine A2 - Pironon, Jacques Y1 - 1997 PY - 1997 DA - 1997 SP - 142 EP - 143 VL - 14 KW - water KW - migration KW - maturity KW - in situ KW - overgrowths KW - aliphatic hydrocarbons KW - petroleum KW - temperature KW - carbon dioxide KW - volatiles KW - organic compounds KW - infrared spectroscopy KW - mixing KW - hydrogen KW - diagenesis KW - inclusions KW - hydrocarbons KW - synchrotrons KW - fluid inclusions KW - applications KW - cement KW - spectroscopy KW - 29A:Economic geology, geology of energy sources KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52380764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+...+European+Current+Research+on+Fluid+Inclusions+%28ECROFI%29&rft.atitle=Infrared+synchrotron+microspectrometry%3B+applications+to+microanalysis+in+the+micron+scale+range&rft.au=Guilhoumou%2C+Nicole%3BDumas%2C+Paul%3BCarr%2C+G+Larry%3BWilliams%2C+Gwyn+Philipp&rft.aulast=Guilhoumou&rft.aufirst=Nicole&rft.date=1997-01-01&rft.volume=14&rft.issue=&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+...+European+Current+Research+on+Fluid+Inclusions+%28ECROFI%29&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - XIVth European current research on fluid inclusions; XIV ECROFI N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #05159 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; applications; carbon dioxide; cement; diagenesis; fluid inclusions; hydrocarbons; hydrogen; in situ; inclusions; infrared spectroscopy; maturity; migration; mixing; organic compounds; overgrowths; petroleum; spectroscopy; synchrotrons; temperature; volatiles; water ER - TY - JOUR T1 - Photosynthetic rates derived from satellite-based chlorophyll concentration AN - 1808728611; PQ0003341037 AB - We assembled a dataset of super(14)C-based productivity measurements to understand the critical variables required for accurate assessment of daily depth-integrated phytoplankton carbon fixation (PP(PP sub(eu)) sub(u)) from measurements of sea surface pigment concentrations (C sub(sat))(C sub(sat)). From this dataset, we developed a light-dependent, depth-resolved model for carbon fixation (VGPM) that partitions environmental factors affecting primary production into those that influence the relative vertical distribution of primary production (Pz)z) and those that control the optimal assimilation efficiency of the productivity profile (P(P super(B) sub(opt)). The VGPM accounted for 79% of the observed variability in P sub(z) and 86% of the variability in PP sub(eu) by using measured values of P super(B) sub(opt). Our results indicate that the accuracy of productivity algorithms in estimating PP sub(eu) is dependent primarily upon the ability to accurately represent variability in P super(b)opt. We developed a temperature-dependent P super(b) sub(opt) model that was used in conjunction with monthly climatological images of C sub(sat) sea surface temperature, and cloud-corrected estimates of surface irradiance to calculate a global annual phytoplankton carbon fixation (PP sub(annu)) rate of 43.5 Pg C yr super(1). The geographical distribution of PP sub(annu) was distinctly different than results from previous models. Our results illustrate the importance of focusing P super(b) sub(opt) model development on temporal and spatial, rather than the vertical, variability. JF - Limnology and Oceanography AU - Behrenfeld, Michael J AU - Falkowski, Paul G AD - Oceanographic and Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York 11973-5000. Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 1 EP - 20 PB - Association for the Sciences of Limnology and Oceanography VL - 42 IS - 1 SN - 0024-3590, 0024-3590 KW - Ecology Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Sea surface KW - Chlorophylls KW - Variability KW - Chlorophyll KW - Geographical distribution KW - Irradiance KW - Photosynthesis KW - Algorithms KW - Limnology KW - Phytoplankton KW - Environmental factors KW - Primary production KW - Carbon KW - Pigments KW - Ocean-atmosphere system KW - Modelling KW - Temperature effects KW - Marine KW - Vertical distribution KW - Primary Productivity KW - Oceanography KW - Water temperature KW - Model Studies KW - Productivity KW - Carbon fixation KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808728611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Photosynthetic+rates+derived+from+satellite-based+chlorophyll+concentration&rft.au=Behrenfeld%2C+Michael+J%3BFalkowski%2C+Paul+G&rft.aulast=Behrenfeld&rft.aufirst=Michael&rft.date=1997-01-01&rft.volume=42&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1997.42.1.0001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Temperature effects; Chlorophylls; Sea surface; Vertical distribution; Geographical distribution; Photosynthesis; Phytoplankton; Water temperature; Primary production; Environmental factors; Ocean-atmosphere system; Modelling; Carbon fixation; Chlorophyll; Irradiance; Pigments; Algorithms; Variability; Carbon; Primary Productivity; Limnology; Oceanography; Productivity; Model Studies; Marine DO - http://dx.doi.org/10.4319/lo.1997.42.1.0001 ER - TY - CONF T1 - Methanol as an agent for CO sub(2) mitigation AN - 16456836; 4380548 AB - The Carnol System consists of methanol production by CO sub(2) recovered from coal fired power plants and natural gas and the use of the methanol as an alternative automotive fuel. The Carnol Process produces hydrogen by the thermal decomposition of natural gas and reacting the hydrogen with CO sub(2) recovered from the power plant. The carbon produced can be stored or used as a materials commodity. A design and economic evaluation of the process is presented and compared to gasoline as an automotive fuel. An evaluation of the CO sub(2) emission reduction of the process and system is made and compared to other conventional methanol production processes including the use of biomass feedstock and methanol fuel cell vehicles. The CO sub(2) emission for the entire Carnol System using methanol in automotive IC engines can be reduced by 56% compared to the conventional system of coal fuel power plants and gasoline driven engines and by as much as 77% CO sub(2) emission reduction when methanol is used in fuel cells for automotive purposes. The Carnol System is shown to be an environmentally attractive and economically viable system connecting the power generation sector with the transportation sector which should warrant further development. JF - ENERGY CONVERS. MANAGE. AU - Steinberg, M Y1 - 1997 PY - 1997 DA - 1997 SP - S423 EP - S430 VL - 38 KW - methanol KW - Pollution Abstracts KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16456836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ENERGY+CONVERS.+MANAGE.&rft.atitle=Methanol+as+an+agent+for+CO+sub%282%29+mitigation&rft.au=Steinberg%2C+M&rft.aulast=Steinberg&rft.aufirst=M&rft.date=1997-01-01&rft.volume=38&rft.issue=&rft.spage=S423&rft.isbn=&rft.btitle=&rft.title=ENERGY+CONVERS.+MANAGE.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Decreases in dopamine receptors but not in dopamine transporters in alcoholics. AN - 78655926; 8986209 AB - It has been hypothesized that ethanol's actions on the dopamine (DA) system may participate in addiction. The purpose of this study was to evaluate the DA system in the brain of alcoholics. We evaluated 10 alcoholics and 17 nonalcoholics using positron emission tomography and [11C]raclopride to measure DA D2 receptors. In addition, in 5 of the alcoholics and 16 of the nonalcoholics, we also measured DA transporters with [11C]d-threo methylphenidate. The ratio of the distribution volumes in striatum to that in cerebellum, which corresponds to Bmax/Kd + 1, was used as model parameter of DA D2 receptor and transporter availability. Dopamine D2 receptor availability (Bmax/Kd) was significantly lower in alcoholics (2.1 +/- 0.5) than in nonalcoholics (2.7 +/- 0.6) (p < 0.05) and was not correlated with days since last alcohol use. Alcoholics showed DA transporter values similar to those in nonalcoholics. The ratio of DA D2 receptor to transporter availability was significantly higher in nonalcoholics (1.4 +/- 0.1) than in alcoholics (1.1 +/- 0.1) (p < 0.005). Alcoholics showed significant reductions in D2 receptors (postsynaptic marker) but not in DA transporter availability (presynaptic marker) when compared with nonalcoholics. Because D2 receptors in striatum are mainly localized in gamma-aminobutyric acid (GABA) cells these results provide evidence of GABAergic involvement in the dopaminergic abnormalities seen in alcoholics. JF - Alcoholism, clinical and experimental research AU - Volkow, N D AU - Wang, G J AU - Fowler, J S AU - Logan, J AU - Hitzemann, R AU - Ding, Y S AU - Pappas, N AU - Shea, C AU - Piscani, K AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996/12// PY - 1996 DA - December 1996 SP - 1594 EP - 1598 VL - 20 IS - 9 SN - 0145-6008, 0145-6008 KW - Carbon Radioisotopes KW - 0 KW - Carrier Proteins KW - Dopamine Plasma Membrane Transport Proteins KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Receptors, Dopamine KW - Salicylamides KW - Methylphenidate KW - 207ZZ9QZ49 KW - Ethanol KW - 3K9958V90M KW - Raclopride KW - 430K3SOZ7G KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Ethanol -- pharmacology KW - Corpus Striatum -- metabolism KW - Humans KW - Alcohol Drinking KW - Corpus Striatum -- diagnostic imaging KW - Adult KW - Tomography, Emission-Computed KW - gamma-Aminobutyric Acid -- metabolism KW - Female KW - Male KW - Receptors, Dopamine -- drug effects KW - Carrier Proteins -- metabolism KW - Alcoholism -- diagnostic imaging KW - Carrier Proteins -- drug effects KW - Dopamine -- metabolism KW - Alcoholism -- metabolism KW - Brain -- metabolism KW - Brain -- diagnostic imaging KW - Receptors, Dopamine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78655926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Decreases+in+dopamine+receptors+but+not+in+dopamine+transporters+in+alcoholics.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BFowler%2C+J+S%3BLogan%2C+J%3BHitzemann%2C+R%3BDing%2C+Y+S%3BPappas%2C+N%3BShea%2C+C%3BPiscani%2C+K&rft.aulast=Volkow&rft.aufirst=N&rft.date=1996-12-01&rft.volume=20&rft.issue=9&rft.spage=1594&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-12 N1 - Date created - 1997-03-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Potential health hazards from lead shielding. AN - 78636566; 8976587 AB - Uncoated metallic lead is widely used as radiation shielding in research and development, nuclear medicine and radiology, and various manufacturing processes. The common use of lead shielding, however, may present an insidious health hazard due to lead dust. Field and laboratory measurements were collected to evaluate the distribution and removal of lead from radiation shielding material as well as to measure airborne exposures during large shielding emplacement projects. The data indicate that lead is readily dispersed from visibly oxidized as well as freshly-cleaned shielding, but that a single coating of polyurethane can reduce lead removal by nearly three orders of magnitude. Although 8-hour time-weighted average exposures for workers constructing lead shielding structures were nearly all below the Occupational Safety and Health Administration's action level of 30 micrograms/m3 (due to short work periods), the distribution of airborne lead concentrations during this kind of work demonstrates a potential for overexposure. JF - American Industrial Hygiene Association journal AU - Klein, R C AU - Weilandics, C AD - Safety & Environmental Protection Division, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996/12// PY - 1996 DA - December 1996 SP - 1124 EP - 1126 VL - 57 IS - 12 SN - 0002-8894, 0002-8894 KW - Air Pollutants, Occupational KW - 0 KW - Polyurethanes KW - Lead KW - 2P299V784P KW - Index Medicus KW - Maximum Allowable Concentration KW - Humans KW - Time Factors KW - Environmental Monitoring KW - Lead -- adverse effects KW - Air Pollutants, Occupational -- analysis KW - Air Pollutants, Occupational -- adverse effects KW - Lead -- analysis KW - Radiation Protection -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78636566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Potential+health+hazards+from+lead+shielding.&rft.au=Klein%2C+R+C%3BWeilandics%2C+C&rft.aulast=Klein&rft.aufirst=R&rft.date=1996-12-01&rft.volume=57&rft.issue=12&rft.spage=1124&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-16 N1 - Date created - 1997-01-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters. AN - 77898963; 10638828 JF - Synapse (New York, N.Y.) AU - Volkow, N D AU - Gatley, S J AU - Fowler, J S AU - Logan, J AU - Fischman, M AU - Gifford, A N AU - Pappas, N AU - King, P AU - Vitkun, S AU - Ding, Y S AU - Wang, G J AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@brain.med.bnl.gov Y1 - 1996/12// PY - 1996 DA - December 1996 SP - 399 EP - 402 VL - 24 IS - 4 SN - 0887-4476, 0887-4476 KW - Carrier Proteins KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Kinetics KW - Humans KW - Tomography, Emission-Computed KW - Brain -- diagnostic imaging KW - Binding Sites KW - Carrier Proteins -- metabolism KW - Cocaine -- metabolism KW - Cocaine -- administration & dosage KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77898963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Cocaine+doses+equivalent+to+those+abused+by+humans+occupy+most+of+the+dopamine+transporters.&rft.au=Volkow%2C+N+D%3BGatley%2C+S+J%3BFowler%2C+J+S%3BLogan%2C+J%3BFischman%2C+M%3BGifford%2C+A+N%3BPappas%2C+N%3BKing%2C+P%3BVitkun%2C+S%3BDing%2C+Y+S%3BWang%2C+G+J&rft.aulast=Volkow&rft.aufirst=N&rft.date=1996-12-01&rft.volume=24&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-27 N1 - Date created - 2000-01-27 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Water-table altitude near the Brookhaven National Laboratory, Suffolk County, New York, in March 1995 AN - 52673927; 1997-068453 JF - Fact Sheet - U. S. Geological Survey AU - Scorca, Michael P AU - Dorsch, William R AU - Paquette, Douglas E Y1 - 1996/12// PY - 1996 DA - December 1996 SP - 4 PB - U. S. Geological Survey, Reston, VA KW - Type: hydrogeologic map KW - United States KW - Brookhaven National Laboratory KW - altitude KW - hydrogeology KW - hydrogeologic maps KW - elementary geology KW - measurement KW - ground water KW - aquifers KW - Suffolk County New York KW - water table KW - Pine Barrens KW - New York KW - maps KW - Long Island KW - USGS KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52673927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Scorca%2C+Michael+P%3BDorsch%2C+William+R%3BPaquette%2C+Douglas+E&rft.aulast=Scorca&rft.aufirst=Michael&rft.date=1996-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Water-table+altitude+near+the+Brookhaven+National+Laboratory%2C+Suffolk+County%2C+New+York%2C+in+March+1995&rft.title=Water-table+altitude+near+the+Brookhaven+National+Laboratory%2C+Suffolk+County%2C+New+York%2C+in+March+1995&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 9 N1 - Availability - U. S. Geol. Surv., Denver, CO, United States N1 - PubXState - VA N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - #03880 N1 - SubjectsTermNotLitGenreText - altitude; aquifers; Brookhaven National Laboratory; elementary geology; ground water; hydrogeologic maps; hydrogeology; Long Island; maps; measurement; New York; Pine Barrens; Suffolk County New York; United States; USGS; water table ER - TY - JOUR T1 - Brookhaven National Laboratory site environmental report for calendar year 1995 AN - 52412968; 2000-000193 AB - This report documents the results of the Environmental Monitoring Program at Brookhaven National Laboratory and summarizes information about environmental compliance for 1995. To evaluate the effect of Brookhaven National Laboratory's operations on the local environment, measurements of direct radiation, and of a variety of radionuclides and chemical compounds in the ambient air, soil, sewage effluent, surface water, groundwater, fauna, and vegetation were made at the Brookhaven National Laboratory site and at adjacent sites. The report also evaluates the Laboratory's compliance with all applicable guides, standards, and limits for radiological and nonradiological emissions and effluents to the environment. Areas of known contamination are subject to Remedial Investigation/Feasibility Studies under the Inter Agency Agreement established by the Department of Energy, Environmental Protection Agency and the New York Department of Environmental Conservation. Except for identified areas of soil and groundwater contamination, the environmental monitoring data has continued to demonstrate that compliance was achieved with the applicable environmental laws and regulations governing emission and discharge of materials to the environment. Also, the data show that the environmental impacts at Brookhaven National Laboratory are minimal and pose no threat to the public nor to the environment. This report meets the requirements of Department of Energy Orders 5484.1, Environmental Protection, Safety, and Health Protection Information reporting requirements and 5400.1, General Environmental Protection Programs. JF - BNL (Brookhaven National Laboratory) AU - Naidu, J R AU - Paquette, D E AU - Schroeder, G L Y1 - 1996/12// PY - 1996 DA - December 1996 SP - 332 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - United States KW - monitoring KW - isotopes KW - Brookhaven National Laboratory KW - pollutants KW - effluents KW - annual report KW - pollution KW - remediation KW - radioactive waste KW - Suffolk County New York KW - New York KW - safety KW - radioactive isotopes KW - report KW - air KW - waste disposal KW - water pollution KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52412968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Naidu%2C+J+R%3BPaquette%2C+D+E%3BSchroeder%2C+G+L&rft.aulast=Naidu&rft.aufirst=J&rft.date=1996-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Brookhaven+National+Laboratory+site+environmental+report+for+calendar+year+1995&rft.title=Brookhaven+National+Laboratory+site+environmental+report+for+calendar+year+1995&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 2000-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE97004805NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - air; annual report; Brookhaven National Laboratory; effluents; isotopes; monitoring; New York; pollutants; pollution; radioactive isotopes; radioactive waste; remediation; report; safety; Suffolk County New York; United States; waste disposal; water pollution ER - TY - JOUR T1 - Radiation effects induced by low doses in complex tissue and their relation to cellular adaptive responses. AN - 78574904; 8946025 JF - Mutation research AU - Feinendegen, L E AU - Bond, V P AU - Sondhaus, C A AU - Muehlensiepen, H AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996/11/04/ PY - 1996 DA - 1996 Nov 04 SP - 199 EP - 205 VL - 358 IS - 2 SN - 0027-5107, 0027-5107 KW - Index Medicus KW - Space life sciences KW - Animals KW - Risk Factors KW - Humans KW - Neoplasms, Radiation-Induced KW - Mice KW - Bone Marrow -- radiation effects KW - Linear Energy Transfer KW - Adaptation, Physiological KW - Dose-Response Relationship, Radiation KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78574904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Radiation+effects+induced+by+low+doses+in+complex+tissue+and+their+relation+to+cellular+adaptive+responses.&rft.au=Feinendegen%2C+L+E%3BBond%2C+V+P%3BSondhaus%2C+C+A%3BMuehlensiepen%2C+H&rft.aulast=Feinendegen&rft.aufirst=L&rft.date=1996-11-04&rft.volume=358&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-30 N1 - Date created - 1996-12-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Does detoxification reverse the acute lung injury of crack smokers? AN - 78627010; 8971868 AB - The effect on chronic crack users of a 3 month detoxification programme on lung clearance of inhaled 99Tcm-diethylenetriamine pentaacetate (99Tcm-DTPA) aerosol, spirometry and gas exchange was determined in a controlled in-patient clinical treatment setting. Imaging studies were carried out in eight chronic crack users (four crack-only and four crack plus tobacco) before and after the successful completion of the detoxification programme to measure the clearance of inhaled 99Tcm-DTPA from the lungs, an index of lung epithelial permeability. 99Tcm-DTPA lung clearance, expressed in terms of the biological half-time, T1/2, was determined from the slopes of the least-squares fit regression lines of the respective time-activity plots. The mean (+/- S.D.) global T1/2 values of the crack-only (75 +/- 39 min) and crack plus tobacco users (22 +/- 10 min) were significantly shorter (P < 0.02 and P < 0.001, respectively) than from the lungs of the non-smoking controls (124 +/- 29 min). This was consistent with increased lung epithelial permeability secondary to crack-related lung injury. The mean global T1/2 value of the crack plus tobacco users was significantly shorter (P < 0.05) than that of the crack-only users. After detoxification, the abnormally rapid lung clearance became normal in two of the four crack-only users studied, improved in a third and remained unchanged in the fourth, a subject whose T1/2 value was already normal initially. However, lung clearance improved in only one of the four crack plus tobacco users studied. Faster 99Tcm-DTPA clearance was the only impairment found in seven of the eight crack users, the eighth having restrictive lung disease. Crack-related lung injury, reflected by abnormally rapid 99Tcm-DTPA lung clearance, may be at least partially reversible after a 3 month period of abstinence from crack. JF - Nuclear medicine communications AU - Susskind, H AU - Weber, D A AU - Atkins, H L AU - Franceschi, D AU - Volkow, N D AD - Clinical Research Center, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 963 EP - 970 VL - 17 IS - 11 SN - 0143-3636, 0143-3636 KW - Crack Cocaine KW - 0 KW - Carbon Dioxide KW - 142M471B3J KW - Oxygen KW - S88TT14065 KW - Technetium Tc 99m Pentetate KW - VW78417PU1 KW - Index Medicus KW - Smoking KW - Spirometry -- methods KW - Vital Capacity KW - Oxygen -- blood KW - Humans KW - Adult KW - Metabolic Clearance Rate KW - Forced Expiratory Volume KW - Time Factors KW - Carbon Dioxide -- blood KW - Radionuclide Imaging KW - Lung -- diagnostic imaging KW - Opioid-Related Disorders -- complications KW - Tobacco Use Disorder -- rehabilitation KW - Technetium Tc 99m Pentetate -- pharmacokinetics KW - Opioid-Related Disorders -- rehabilitation KW - Lung -- physiopathology KW - Tobacco Use Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78627010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+medicine+communications&rft.atitle=Does+detoxification+reverse+the+acute+lung+injury+of+crack+smokers%3F&rft.au=Susskind%2C+H%3BWeber%2C+D+A%3BAtkins%2C+H+L%3BFranceschi%2C+D%3BVolkow%2C+N+D&rft.aulast=Susskind&rft.aufirst=H&rft.date=1996-11-01&rft.volume=17&rft.issue=11&rft.spage=963&rft.isbn=&rft.btitle=&rft.title=Nuclear+medicine+communications&rft.issn=01433636&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-22 N1 - Date created - 1997-05-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Eruption history of the Changbeishan volcanoes, NE China; constraint by K-Ar and C-14 dating and historical records AN - 52622482; 1998-020286 JF - Eos, Transactions, American Geophysical Union AU - Song, Sheng-Rong AU - Liu, Ruoxin AU - Tsao, Shuhjong AU - Liu, Chiachi AU - Liu, Xiang AU - Anonymous Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 794 PB - American Geophysical Union, Washington, DC VL - 77 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - Far East KW - volcanic rocks KW - Changbai Mountains KW - isotopes KW - igneous rocks KW - northeastern China KW - Cenozoic KW - volcanic features KW - radioactive isotopes KW - dates KW - volcanism KW - trachytes KW - carbon KW - basalts KW - phreatomagmatism KW - absolute age KW - shield volcanoes KW - Asia KW - China KW - rhyolites KW - Quaternary KW - calderas KW - pyroclastics KW - K/Ar KW - lava KW - eruptions KW - upper Quaternary KW - volcanoes KW - C-14 KW - cones KW - 24:Quaternary geology KW - 03:Geochronology KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52622482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Eruption+history+of+the+Changbeishan+volcanoes%2C+NE+China%3B+constraint+by+K-Ar+and+C-14+dating+and+historical+records&rft.au=Song%2C+Sheng-Rong%3BLiu%2C+Ruoxin%3BTsao%2C+Shuhjong%3BLiu%2C+Chiachi%3BLiu%2C+Xiang%3BAnonymous&rft.aulast=Song&rft.aufirst=Sheng-Rong&rft.date=1996-11-01&rft.volume=77&rft.issue=46%2C+Suppl.&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1996 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - absolute age; Asia; basalts; C-14; calderas; carbon; Cenozoic; Changbai Mountains; China; cones; dates; eruptions; Far East; igneous rocks; isotopes; K/Ar; lava; northeastern China; phreatomagmatism; pyroclastics; Quaternary; radioactive isotopes; rhyolites; shield volcanoes; trachytes; upper Quaternary; volcanic features; volcanic rocks; volcanism; volcanoes ER - TY - JOUR T1 - Synchrotron micro-infrared spectroscopy; applications to hydrous mantle minerals AN - 52529693; 1999-000776 JF - Eos, Transactions, American Geophysical Union AU - Lu, R AU - Hemley, R J AU - Mao, H K AU - Carr, G L AU - Williams, G P AU - Anonymous Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 661 PB - American Geophysical Union, Washington, DC VL - 77 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - synchrotron radiation KW - methods KW - hydrates KW - infrared spectroscopy KW - experimental studies KW - mantle KW - applications KW - anvil cells KW - spectroscopy KW - review KW - 17B:Geophysics of minerals and rocks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52529693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Synchrotron+micro-infrared+spectroscopy%3B+applications+to+hydrous+mantle+minerals&rft.au=Lu%2C+R%3BHemley%2C+R+J%3BMao%2C+H+K%3BCarr%2C+G+L%3BWilliams%2C+G+P%3BAnonymous&rft.aulast=Lu&rft.aufirst=R&rft.date=1996-11-01&rft.volume=77&rft.issue=46%2C+Suppl.&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1996 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - anvil cells; applications; experimental studies; hydrates; infrared spectroscopy; mantle; methods; review; spectroscopy; synchrotron radiation ER - TY - JOUR T1 - Selection, identification, and genetic analysis of random mutants in the cloned primase/helicase gene of bacteriophage T7. AN - 78510751; 8900163 AB - T7 gene 4 specifies two overlapping proteins 4A, a 566-amino acid primase/helicase, and 4B, a 503-amino acid helicase whose initiation codon is the 64th codon of the 4A protein. The 4A' gene, which has a leucine codon replacing the 4B initiation codon, specifies a single 566-amino acid protein that can provide the primase and helicase functions required for normal T7 growth. We selected N-methyl-N'-nitro-N-nitrosoguanidine mutants in the cloned 4A' gene that no longer support the growth of a phage that completely lacks gene 4. Genetic mapping of the 76 mutations found them to be distributed throughout the protein, including both the N-terminal and C-terminal halves of the molecule thought to represent primase and helicase domains, respectively. Complementation tests with partially and completely defective phage showed that all but five of the mutants lacked helicase function but retained primase function. The other five, which lacked both functions, all made short proteins, including one missing only 60 amino acids. No mutations lacked only primase function, and none mapped within the first 105 amino acids, which includes the 63-amino acid region unique to 4A that contains elements required to recognize primase sites. Forty-six mutations were sequenced and included 27 missense mutations affecting 25 amino acids. Many mutations in the N-terminal half of the protein affected its solubility in cell extracts. Mutations in the C-terminal half clustered in or near five helicase consensus sequences. Biochemical analysis of nine of the mutant proteins is described in the accompanying paper (Washington, M. T., Rosenberg, A. H., Griffin, K., Studier, F. W., and Patel, S. S. (1996) J. Biol. Chem. 271, 26825-26834). JF - The Journal of biological chemistry AU - Rosenberg, A H AU - Griffin, K AU - Washington, M T AU - Patel, S S AU - Studier, F W AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1996/10/25/ PY - 1996 DA - 1996 Oct 25 SP - 26819 EP - 26824 VL - 271 IS - 43 SN - 0021-9258, 0021-9258 KW - DNA Primase KW - EC 2.7.7.- KW - RNA Nucleotidyltransferases KW - Index Medicus KW - Solubility KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Consensus Sequence KW - Mutagenesis KW - Cloning, Molecular KW - T-Phages -- enzymology KW - RNA Nucleotidyltransferases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78510751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Selection%2C+identification%2C+and+genetic+analysis+of+random+mutants+in+the+cloned+primase%2Fhelicase+gene+of+bacteriophage+T7.&rft.au=Rosenberg%2C+A+H%3BGriffin%2C+K%3BWashington%2C+M+T%3BPatel%2C+S+S%3BStudier%2C+F+W&rft.aulast=Rosenberg&rft.aufirst=A&rft.date=1996-10-25&rft.volume=271&rft.issue=43&rft.spage=26819&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-16 N1 - Date created - 1996-12-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Microdosimetry of monoenergetic neutrons. AN - 78509954; 8927719 AB - Tissue spheres 0.25, 0.5, 1.0, 2.0, 4.0 and 8.0 micron in diameter were simulated using a wall-less spherical counter filled with propane-based tissue-equivalent gas. Microdosimetric spectra corresponding to these site sizes were measured for five neutron energies (0.22, 0.44, 1.5, 6 and 14 MeV) and the related mean values /yF and /yD were calculated for several site sizes and neutron energies. An elaborate calibration technique combining soft X rays, an 55Fe photon source and a collimated 244Cm alpha-particle source was used throughout the measurements. The spectra and their mean values are compared with theoretically calculated values for ICRU standard tissue. The agreement between the calculated and the measured data is good in spite of a systematic discrepancy, which could be attributed, in part, to the difference in elemental composition between the tissue-equivalent gas and plastic used in the counter and the ICRU standard tissue used in the calculations. JF - Radiation research AU - Srdoc, D AU - Marino, S A AD - Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1996/10// PY - 1996 DA - October 1996 SP - 466 EP - 474 VL - 146 IS - 4 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Radiometry KW - In Vitro Techniques KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Linear Energy Transfer KW - Radiobiology KW - Microspheres KW - Fast Neutrons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78509954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Microdosimetry+of+monoenergetic+neutrons.&rft.au=Srdoc%2C+D%3BMarino%2C+S+A&rft.aulast=Srdoc&rft.aufirst=D&rft.date=1996-10-01&rft.volume=146&rft.issue=4&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-11-20 N1 - Date created - 1996-11-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Synthesis of a nickel tetracarboranylphenylporphyrin for boron neutron-capture therapy: biodistribution and toxicity in tumor-bearing mice. AN - 78487635; 8895550 AB - Nickel-2,3,7,8,12,13,17,18-octaacetic acid-5,10,15,20-tetra-[3-carboranyl-methoxyphenyl]-porphyrin octamethylester (NiTCP) was given in a Cremophor EL, a polyethoxylated castor oil, and propylene glycol emulsion to BALB/c mice bearing transplanted s.c. KHJJ mammary carcinomas. A total dose of 244 microg NiTCP/gram body weight (gbw) (54 microg B/gbw) was given in 6 i.p. injections over a 32 hr period. Observations of behavior and changes in body weight and chemical and hematological blood tests indicated little or no toxicity from NiTCP over a period of 6-90 hr after injections. Boron concentrations near tumor margins were 160-180 microg B/g at 41-90 hr after the last injection. Tumor:normal brain boron concentration ratios reached approx. 10:1 and tumor:blood ratios reached approx. 250:1 after 4 days. There was no evidence of thrombocytopenia or other potentially important toxicities. Our findings place NiTCP among the leading candidates for pre-clinical experiments aimed toward improvement upon the compounds being tested for boron neutron-capture therapy of glioblastoma multiforme. JF - International journal of cancer AU - Miura, M AU - Micca, P L AU - Fisher, C D AU - Heinrichs, J C AU - Donaldson, J A AU - Finkel, G C AU - Slatkin, D N AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 1996/09/27/ PY - 1996 DA - 1996 Sep 27 SP - 114 EP - 119 VL - 68 IS - 1 SN - 0020-7136, 0020-7136 KW - Metalloporphyrins KW - 0 KW - nickel-2,3,7,8,12,13,17,18-octaacetic acid-5,10,15,20-tetra-(3-carboranylmethoxyphenyl)porphyrin octamethyl ester KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Boron KW - N9E3X5056Q KW - Index Medicus KW - Animals KW - Brain Chemistry KW - Mice KW - Tissue Distribution KW - Blood Urea Nitrogen KW - Alkaline Phosphatase -- blood KW - Mice, Inbred BALB C KW - Boron -- analysis KW - Neoplasm Transplantation KW - Alanine Transaminase -- blood KW - Kinetics KW - Boron -- blood KW - Female KW - Metalloporphyrins -- toxicity KW - Mammary Neoplasms, Experimental -- radiotherapy KW - Metalloporphyrins -- chemical synthesis KW - Mammary Neoplasms, Experimental -- chemistry KW - Metalloporphyrins -- pharmacokinetics KW - Boron Neutron Capture Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78487635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Synthesis+of+a+nickel+tetracarboranylphenylporphyrin+for+boron+neutron-capture+therapy%3A+biodistribution+and+toxicity+in+tumor-bearing+mice.&rft.au=Miura%2C+M%3BMicca%2C+P+L%3BFisher%2C+C+D%3BHeinrichs%2C+J+C%3BDonaldson%2C+J+A%3BFinkel%2C+G+C%3BSlatkin%2C+D+N&rft.aulast=Miura&rft.aufirst=M&rft.date=1996-09-27&rft.volume=68&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-13 N1 - Date created - 1996-12-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - RPRT T1 - In-situ vitrification (ISV) organic-surrogate vapor emissions during a 1-ton pilot melt; Draft report AN - 52168401; 2002-000012 AB - Pilot tests of a commercial soil vitrification process for entombing Animal/Chemical and Glass Hole area wastes were evaluated by incorporating perfluorocarbon tracers (PFTs) into aqueous and organic "wastes" within bottles of the type buried in typical Brookhaven-type holes. The objective was to add sufficient known PFT quantities of two or more types in the aqueous and organic phases while, at the same time, surrounding the test pit with known emission rate PFT sources, one type in the soil and another type in the air, such that monitoring of the air above ground and below ground would allow computation of the fugitive emission rates from the process as it occurred. Hood off-gas PFT concentrations were also to be monitored in order to verify the fraction present. The output was to be the percentage escape (i.e., not captured by the hood) of pit aqueous and organic phases as the vitrification process proceeded. The actual melt commenced at 1350 on Monday 24 June 1996 and continued for just short of 48 hours. By the next day it was clear from the real-time PFT analyzer that above-ground fugitive emissions were not assessable because substantial PFT vapors were fumigating the area from the exhaust stack of the ISV hood's soil vapor extraction (SVE) processing system. That sampling component was then switched to the stack to compare hood off-gas concentrations before and after the charcoal filtering. JF - In-situ vitrification (ISV) organic-surrogate vapor emissions during a 1-ton pilot melt; Draft report AU - Dietz, R N AU - Wieser, R F AU - Fajer, R W Y1 - 1996/09// PY - 1996 DA - September 1996 SP - 51 VL - BNL-63981 KW - soils KW - degradation KW - in situ KW - pollutants KW - soil vapor extraction KW - pollution KW - migration of elements KW - remediation KW - volatiles KW - organic compounds KW - transport KW - vitrification KW - volatile organic compounds KW - ecology KW - waste disposal KW - mobility KW - underground disposal KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52168401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Dietz%2C+R+N%3BWieser%2C+R+F%3BFajer%2C+R+W&rft.aulast=Dietz&rft.aufirst=R&rft.date=1996-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=In-situ+vitrification+%28ISV%29+organic-surrogate+vapor+emissions+during+a+1-ton+pilot+melt%3B+Draft+report&rft.title=In-situ+vitrification+%28ISV%29+organic-surrogate+vapor+emissions+during+a+1-ton+pilot+melt%3B+Draft+report&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 2002-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE97003585NEG, Springfield, VA, United States N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Methyl iodide in the Greenland/Norwegian seas and the tropical Atlantic Ocean; evidence for photochemical production AN - 50169489; 1996-069969 AB - CH (sub 3) I was measured in open ocean waters during two cruises to the tropical Atlantic Ocean and a late fall cruise to the Greenland and Norwegian Seas (GSNS). In warm, tropical surface waters subject to high solar irradiance, average CH (sub 3) I saturation anomalies were positive (1.5-7.7 pmol kg (super -1) ), indicating a sea-to-air flux. This contrasted with negative saturation anomalies (-0.65 + or - 0.02 pmol kg (super -1) ) measured in cold surface waters of the open ocean GSNS subject to low-light. High latitude oceans may therefore be a significant sink for atmospheric CH (sub 3) during the fall and winter. The locations and/or seasons where samples were analyzed were all characterized by relatively low biological production and the CH (sub 3) I saturation anomaly along 19 degrees S decreased from 7.7 + or - 0.6 to 3.4 + or - 0.4 pmol kg (super -1) when entering a more productive upwelling zone. Taken together these observations suggest a chemical, as opposed to biological, production mechanism for this compound in the open ocean. Within the open ocean of the GSNS, multiple linear regression between the observed CH (sub 3) I saturation anomaly and variables including light intensity, water temperature, CFC-11 saturation (indicator of gas exchange and deep mixing), and distance from the Norwegian Coastal Current (indicator of coastal or southern sources) showed that light intensity was the only significant predictor, explaining 79 % of the variance. Photochemical production may therefore be dominant source of CH (sub 3) I within the open ocean and this may have important implications for the large-scale, seasonal cycling of iodine between the ocean and the atmosphere. Copyright 1996 by the American Geophysical Union. JF - Geophysical Research Letters AU - Happell, James D AU - Wallace, Douglas W R Y1 - 1996/08// PY - 1996 DA - August 1996 SP - 2105 EP - 2108 PB - American Geophysical Union, Washington, DC VL - 23 IS - 16 SN - 0094-8276, 0094-8276 KW - tropical environment KW - methyl iodide KW - upwelling KW - sea water KW - Greenland Sea KW - photochemistry KW - atmosphere KW - Norwegian Sea KW - chemical reactions KW - marine environment KW - Arctic Ocean KW - air KW - seasonal variations KW - Equatorial Atlantic KW - Atlantic Ocean KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50169489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Methyl+iodide+in+the+Greenland%2FNorwegian+seas+and+the+tropical+Atlantic+Ocean%3B+evidence+for+photochemical+production&rft.au=Happell%2C+James+D%3BWallace%2C+Douglas+W+R&rft.aulast=Happell&rft.aufirst=James&rft.date=1996-08-01&rft.volume=23&rft.issue=16&rft.spage=2105&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1029%2F96GL01764 L2 - http://www.agu.org/journals/gl/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 25 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - GPRLAJ N1 - SubjectsTermNotLitGenreText - air; Arctic Ocean; Atlantic Ocean; atmosphere; chemical reactions; Equatorial Atlantic; Greenland Sea; marine environment; methyl iodide; Norwegian Sea; photochemistry; sea water; seasonal variations; tropical environment; upwelling DO - http://dx.doi.org/10.1029/96GL01764 ER - TY - JOUR T1 - Accolade. Victor P. Bond. AN - 78036581; 8635900 JF - Health physics AU - Cronkite, E P AD - Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 777 EP - 779 VL - 70 IS - 6 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - History of medicine KW - Bond KW - United States KW - Animals KW - Whole-Body Irradiation KW - History, 20th Century KW - Nuclear Warfare KW - Humans KW - Radiation Effects KW - Health Physics -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78036581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Accolade.+Victor+P.+Bond.&rft.au=Cronkite%2C+E+P&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1996-06-01&rft.volume=70&rft.issue=6&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-11 N1 - Date created - 1996-07-11 N1 - Date revised - 2017-02-17 N1 - People - Bond N1 - Last updated - 2017-02-22 N1 - SubjectsTermNotLitGenreText - Bond ER - TY - JOUR T1 - Various approaches to damage assessment. AN - 78025990; 8635912 AB - There are two main approaches used to assess the damage to human health from exposure to low-level ionizing radiation. The first is a realistic best-estimate approach. The second is performed in support of the development of radiation standards to protect workers and the public, and tends to overestimate risk. This paper reviews these approaches to damage assessments as they have been applied to the development of radiation protection standards and current estimates of risk. Technical issues affected by these two different approaches include use of the linear hypothesis, use of relative and absolute risk projection models, dose-rate effectiveness factor, appropriateness of data sets, and the transfer of risks between populations. The prudent approach may be justified for radiation protection purposes, but scientific estimates of risk should reflect the state-of-the-science and include estimates of uncertainty. JF - Health physics AU - Hamilton, L D AD - Biomedical and Environmental Assessment Group, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 859 EP - 867 VL - 70 IS - 6 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Space life sciences KW - Occupational Exposure KW - Risk KW - Radiation Protection KW - Nuclear Warfare KW - Humans KW - Government Agencies KW - Accidents -- mortality KW - Radiation Monitoring KW - Linear Energy Transfer KW - Male KW - Female KW - Radiation, Ionizing KW - Models, Theoretical KW - Neoplasms, Radiation-Induced -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78025990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Various+approaches+to+damage+assessment.&rft.au=Hamilton%2C+L+D&rft.aulast=Hamilton&rft.aufirst=L&rft.date=1996-06-01&rft.volume=70&rft.issue=6&rft.spage=859&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-11 N1 - Date created - 1996-07-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Current misinterpretations of the linear no-threshold hypothesis. AN - 78025173; 8635914 AB - Contrary to the "linear no-threshold hypothesis," which implies that "any amount, however small" of radiation energy is a serious cancer threat, it is shown here that only relatively quite large amounts of such energy can pose such a threat to a person or population. Key to doing this is to make a sharp distinction between the actual amount of the radiation agent imparted energy, epsilon, which must be expressed in units of joules, and the average concentration or density of energy, epsilon/m (i.e., absorbed dose), which is expressed in units of Gy. With any cellular system, e.g., in tissue culture, one can easily adjust the numbers of cells used at each dose point so that a clearly significant number of radiation-induced quantal responses (e.g., mutations, chromosome aberrations, malignant transformations, cell death), in the absorbed dose range of about 0.7 to 3 or more Gy, can be observed. However, if the number of cells is held constant as the absorbed dose is progressively reduced, a point is reached at which no significant excess is observable. This situation is frequently "remedied" by including more cells at that point, which, of course, can increase the number of malignant transformations sufficiently to render the excess statistically valid. However, because both axes are expressed in relative terms, the data point, despite having gained statistical significance, remains at the same location on the graph. This gives the false impression that no more of the agent energy was added or needed to achieve significance. However, if both coordinates are put in absolute terms, i.e., the actual number of quantal responses vs. imparted energy, and the same exercise of "improving the statistics" at low exposures is attempted, it then becomes evident that any point thus rendered significant must be relocated at a substantially higher energy point on the graph. This demonstrates unequivocally the fallacy in the proof of the "linear hypothesis" which is based on agent concentration response curves and not agent amount. It shows that the smaller the agent concentration (absorbed dose; epsilon/m), the larger the amount of radiation energy that must be added to the system in order to demonstrate a radiation-induced response. This suggests a minimum average energy requirement for production of a radiation-attributable cancer. It Ls concluded that the "linear hypothesis" should be abandoned as the cornerstone of radiation protection and practice. JF - Health physics AU - Bond, V P AU - Wielopolski, L AU - Shani, G AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 877 EP - 882 VL - 70 IS - 6 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Public Health KW - Radiation Protection KW - Neoplasms, Radiation-Induced -- etiology KW - Risk Factors KW - Humans KW - Dose-Response Relationship, Radiation KW - Radiation, Ionizing KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78025173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Current+misinterpretations+of+the+linear+no-threshold+hypothesis.&rft.au=Bond%2C+V+P%3BWielopolski%2C+L%3BShani%2C+G&rft.aulast=Bond&rft.aufirst=V&rft.date=1996-06-01&rft.volume=70&rft.issue=6&rft.spage=877&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-11 N1 - Date created - 1996-07-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Relative biological effectiveness of ionizing radiations determined in tissue (RBE) fails in assessing comparative relative effectiveness in the tissue cells. AN - 78020702; 8635911 AB - The value of the RBE of a test radiation is conventionally determined against a known standard radiation for a chosen response of a selected biological tissue and is expressed as the ratio of tissue absorbed doses at equal effect, or as ratio of magnitudes of the effect at equal absorbed dose. If such an effect is observable as a consequence of responses of individual elements of this tissue, namely the cells, such as induction of cancer that arises from a single cell, the relative biological effectiveness should be expressed as the ratio of the incidences of the effects at equal mean absorbed dose to the cells rather than at equal absorbed dose to tissue. This cell based relative biological effectiveness is here termed the relative local efficiency. Since tissue absorbed dose is a product of the number of energy deposition events in cells of that tissue (N(H)) and the mean absorbed dose to these cells in the exposed tissue (z(1)), per tissue mass equal tissue absorbed doses from different radiation qualities have different values of N(H) and z(1) As a result, for pink mutations in Tradescantia cells, the relative biological effectiveness of 0.43 MeV neutrons is 48 but the relative local efficiency in fact is 2.8. JF - Health physics AU - Feinendegen, L E AU - Bond, V P AU - Sondhaus, C A AD - Medical Department Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 852 EP - 858 VL - 70 IS - 6 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Space life sciences KW - Neutrons KW - X-Rays KW - Gamma Rays KW - Cells, Cultured KW - Plants KW - Dose-Response Relationship, Radiation KW - Linear Energy Transfer KW - Cells -- radiation effects KW - Mutagenesis -- radiation effects KW - Relative Biological Effectiveness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78020702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Relative+biological+effectiveness+of+ionizing+radiations+determined+in+tissue+%28RBE%29+fails+in+assessing+comparative+relative+effectiveness+in+the+tissue+cells.&rft.au=Feinendegen%2C+L+E%3BBond%2C+V+P%3BSondhaus%2C+C+A&rft.aulast=Feinendegen&rft.aufirst=L&rft.date=1996-06-01&rft.volume=70&rft.issue=6&rft.spage=852&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-11 N1 - Date created - 1996-07-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication. AN - 78340870; 8797240 AB - Despite the widespread abuse of marijuana, knowledge about its effects in the human brain is limited. Brain glucose metabolism with and without delta 9 tetrahydrocannabinol (THC) (main psychoactive component of marijuana) was evaluated in eight normal subjects and eight chronic marijuana abusers with positron emission tomography. At baseline, marijuana abusers showed lower relative cerebellar metabolism than normal subjects. THC increased relative cerebellar metabolism in all subjects, but only abusers showed increases in orbitofrontal cortex, prefrontal cortex, and basal ganglia. Cerebellar metabolism during THC intoxication was significantly correlated with the subjective sense of intoxication. The decreased cerebellar metabolism in marijuana abusers at baseline could account for the motor deficits previously reported in these subjects. The activation of orbitofrontal cortex and basal ganglia by THC in the abusers but not in the normal subjects could underlie one of the mechanisms leading to the drive and the compulsion to self-administer the drug observed in addicted individuals. JF - Psychiatry research AU - Volkow, N D AU - Gillespie, H AU - Mullani, N AU - Tancredi, L AU - Grant, C AU - Valentine, A AU - Hollister, L AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996/05/31/ PY - 1996 DA - 1996 May 31 SP - 29 EP - 38 VL - 67 IS - 1 SN - 0165-1781, 0165-1781 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Cerebellum -- diagnostic imaging KW - Humans KW - Frontal Lobe -- diagnostic imaging KW - Dronabinol -- blood KW - Frontal Lobe -- metabolism KW - Tomography, Emission-Computed KW - Chronic Disease KW - Basal Ganglia -- diagnostic imaging KW - Psychomotor Disorders -- chemically induced KW - Paleopathology KW - Cerebellum -- metabolism KW - Basal Ganglia -- metabolism KW - Marijuana Abuse -- complications KW - Marijuana Abuse -- metabolism KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78340870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Brain+glucose+metabolism+in+chronic+marijuana+users+at+baseline+and+during+marijuana+intoxication.&rft.au=Volkow%2C+N+D%3BGillespie%2C+H%3BMullani%2C+N%3BTancredi%2C+L%3BGrant%2C+C%3BValentine%2C+A%3BHollister%2C+L&rft.aulast=Volkow&rft.aufirst=N&rft.date=1996-05-31&rft.volume=67&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-11-22 N1 - Date created - 1996-11-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Relevance of in vivo models in melanoma skin cancer. AN - 78555817; 8934751 JF - Photochemistry and photobiology AU - Setlow, R B AD - Biology Department, Brookhaven National Laboratory, Upton, NY, USA. Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 410 EP - 412 VL - 63 IS - 4 SN - 0031-8655, 0031-8655 KW - Index Medicus KW - Animals KW - Neoplasms, Radiation-Induced -- etiology KW - Cyprinodontiformes KW - Humans KW - Ultraviolet Rays -- adverse effects KW - Disease Models, Animal KW - Mice KW - Mice, Transgenic KW - Opossums KW - Skin Neoplasms -- etiology KW - Melanoma -- etiology KW - Skin Neoplasms -- epidemiology KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78555817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Relevance+of+in+vivo+models+in+melanoma+skin+cancer.&rft.au=Setlow%2C+R+B&rft.aulast=Setlow&rft.aufirst=R&rft.date=1996-04-01&rft.volume=63&rft.issue=4&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-31 N1 - Date created - 1996-12-31 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Mutagenic lesions in carcinogenesis: induction and repair of pyrimidine dimers. AN - 78555736; 8934740 JF - Photochemistry and photobiology AU - Sutherland, B M AD - Biology Department, Brookhaven National Laboratory, Upton, NY, USA. Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 375 EP - 377 VL - 63 IS - 4 SN - 0031-8655, 0031-8655 KW - Pyrimidine Dimers KW - 0 KW - Index Medicus KW - Animals KW - DNA Repair KW - DNA Damage KW - Sunlight -- adverse effects KW - Humans KW - Mutation KW - Neoplasms, Radiation-Induced -- etiology KW - Skin Neoplasms -- etiology KW - Pyrimidine Dimers -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78555736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Mutagenic+lesions+in+carcinogenesis%3A+induction+and+repair+of+pyrimidine+dimers.&rft.au=Sutherland%2C+B+M&rft.aulast=Sutherland&rft.aufirst=B&rft.date=1996-04-01&rft.volume=63&rft.issue=4&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-31 N1 - Date created - 1996-12-31 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Synthesis methods and unit cell volume variations of end member titanite (CaTiOSiO (sub 4) ) AN - 52691294; 1997-055053 JF - Eos, Transactions, American Geophysical Union AU - Xirouchakis, D AU - Kunz, M AU - Parise, J B AU - Lindsley, D H AU - Cox, D AU - Anonymous Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 144 PB - American Geophysical Union, Washington, DC VL - 77 IS - 17, Suppl. SN - 0096-3941, 0096-3941 KW - silicates KW - nesosilicates KW - cell dimensions KW - X-ray diffraction data KW - titanite group KW - orthosilicates KW - unit cell KW - crystal structure KW - synthesis KW - stoichiometry KW - titanite KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52691294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Synthesis+methods+and+unit+cell+volume+variations+of+end+member+titanite+%28CaTiOSiO+%28sub+4%29+%29&rft.au=Xirouchakis%2C+D%3BKunz%2C+M%3BParise%2C+J+B%3BLindsley%2C+D+H%3BCox%2C+D%3BAnonymous&rft.aulast=Xirouchakis&rft.aufirst=D&rft.date=1996-04-01&rft.volume=77&rft.issue=17%2C+Suppl.&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1996 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - cell dimensions; crystal structure; nesosilicates; orthosilicates; silicates; stoichiometry; synthesis; titanite; titanite group; unit cell; X-ray diffraction data ER - TY - JOUR T1 - The BNL Geoscience X-ray Imaging Project (GXRIP) AN - 52603226; 1998-036175 JF - Eos, Transactions, American Geophysical Union AU - Jones, K W AU - Peskin, A M AU - Siddons, D P AU - Andrews, B AU - Dowd, B AU - Anonymous Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 288 PB - American Geophysical Union, Washington, DC VL - 77 IS - 17, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - tomography KW - GXRIP KW - imagery KW - synchrotron computed microtomography KW - Brookhaven National Laboratory KW - Geosciences X-ray Imaging Project KW - data processing KW - mantle KW - reservoir rocks KW - synchrotron radiation KW - Suffolk County New York KW - visualization KW - meteorites KW - X-ray analysis KW - CMT method KW - geochemistry KW - upper mantle KW - programs KW - petrology KW - stress KW - ultrastructure KW - New York KW - cap rocks KW - synchrotrons KW - microtomography KW - instruments KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52603226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=The+BNL+Geoscience+X-ray+Imaging+Project+%28GXRIP%29&rft.au=Jones%2C+K+W%3BPeskin%2C+A+M%3BSiddons%2C+D+P%3BAndrews%2C+B%3BDowd%2C+B%3BAnonymous&rft.aulast=Jones&rft.aufirst=K&rft.date=1996-04-01&rft.volume=77&rft.issue=17%2C+Suppl.&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1996 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Brookhaven National Laboratory; cap rocks; CMT method; data processing; geochemistry; Geosciences X-ray Imaging Project; GXRIP; imagery; instruments; mantle; meteorites; microtomography; New York; petrology; programs; reservoir rocks; stress; Suffolk County New York; synchrotron computed microtomography; synchrotron radiation; synchrotrons; tomography; ultrastructure; United States; upper mantle; visualization; X-ray analysis ER - TY - JOUR T1 - Developments in synchrotron X-ray microtomography for application to flow in porous media AN - 52602486; 1998-036178 JF - Eos, Transactions, American Geophysical Union AU - Hazlett, R D AU - Coles, M E AU - Jones, K W AU - Peskin, A M AU - Siddons, D P AU - Andrews, B AU - Dowd, B AU - Anonymous Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 289 PB - American Geophysical Union, Washington, DC VL - 77 IS - 17, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - tomography KW - limestone KW - GXRIP KW - imagery KW - synchrotron computed microtomography KW - Brookhaven National Laboratory KW - Geosciences X-ray Imaging Project KW - data processing KW - sandstone KW - Europe KW - synchrotron radiation KW - Suffolk County New York KW - France KW - Cenozoic KW - sedimentary rocks KW - X-ray analysis KW - CMT method KW - Fontainebleau Sandstone KW - programs KW - Laroux Limestone KW - Western Europe KW - porous materials KW - Paleogene KW - porosity KW - Tertiary KW - physical properties KW - New York KW - synchrotrons KW - Massangi Limestone KW - carbonate rocks KW - Vosges Sandstone KW - microtomography KW - clastic rocks KW - Oligocene KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52602486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Developments+in+synchrotron+X-ray+microtomography+for+application+to+flow+in+porous+media&rft.au=Hazlett%2C+R+D%3BColes%2C+M+E%3BJones%2C+K+W%3BPeskin%2C+A+M%3BSiddons%2C+D+P%3BAndrews%2C+B%3BDowd%2C+B%3BAnonymous&rft.aulast=Hazlett&rft.aufirst=R&rft.date=1996-04-01&rft.volume=77&rft.issue=17%2C+Suppl.&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1996 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 2 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Brookhaven National Laboratory; carbonate rocks; Cenozoic; clastic rocks; CMT method; data processing; Europe; Fontainebleau Sandstone; France; Geosciences X-ray Imaging Project; GXRIP; imagery; Laroux Limestone; limestone; Massangi Limestone; microtomography; New York; Oligocene; Paleogene; physical properties; porosity; porous materials; programs; sandstone; sedimentary rocks; Suffolk County New York; synchrotron computed microtomography; synchrotron radiation; synchrotrons; Tertiary; tomography; United States; Vosges Sandstone; Western Europe; X-ray analysis ER - TY - JOUR T1 - Determination of topology and transport in porous media using synchrotron computed microtomography AN - 52599120; 1998-036177 JF - Eos, Transactions, American Geophysical Union AU - Adler, P M AU - Thovert, J F AU - Jones, K W AU - Peskin, A M AU - Siddons, D P AU - Andrews, B AU - Dowd, B AU - Anonymous Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 289 PB - American Geophysical Union, Washington, DC VL - 77 IS - 17, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - tomography KW - limestone KW - GXRIP KW - imagery KW - synchrotron computed microtomography KW - Brookhaven National Laboratory KW - Geosciences X-ray Imaging Project KW - data processing KW - sandstone KW - Europe KW - synchrotron radiation KW - Suffolk County New York KW - France KW - Cenozoic KW - sedimentary rocks KW - X-ray analysis KW - topology KW - CMT method KW - Fontainebleau Sandstone KW - programs KW - Laroux Limestone KW - Western Europe KW - porous materials KW - Paleogene KW - porosity KW - Tertiary KW - physical properties KW - New York KW - synchrotrons KW - Massangi Limestone KW - carbonate rocks KW - Vosges Sandstone KW - microtomography KW - clastic rocks KW - Oligocene KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52599120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Determination+of+topology+and+transport+in+porous+media+using+synchrotron+computed+microtomography&rft.au=Adler%2C+P+M%3BThovert%2C+J+F%3BJones%2C+K+W%3BPeskin%2C+A+M%3BSiddons%2C+D+P%3BAndrews%2C+B%3BDowd%2C+B%3BAnonymous&rft.aulast=Adler&rft.aufirst=P&rft.date=1996-04-01&rft.volume=77&rft.issue=17%2C+Suppl.&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1996 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - Number of references - 2 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Brookhaven National Laboratory; carbonate rocks; Cenozoic; clastic rocks; CMT method; data processing; Europe; Fontainebleau Sandstone; France; Geosciences X-ray Imaging Project; GXRIP; imagery; Laroux Limestone; limestone; Massangi Limestone; microtomography; New York; Oligocene; Paleogene; physical properties; porosity; porous materials; programs; sandstone; sedimentary rocks; Suffolk County New York; synchrotron computed microtomography; synchrotron radiation; synchrotrons; Tertiary; tomography; topology; United States; Vosges Sandstone; Western Europe; X-ray analysis ER - TY - JOUR T1 - Media axis analysis of void structure in three-dimensional tomographic images of porous media AN - 50179187; 1996-048598 AB - We introduce the medial axis as a tool in the analysis of geometric structure of void space in porous media. The medial axis traces the fundamental geometry of the void pathways. We describe an algorithm for generating the medial axis of the void structure from digitized three dimensional images of porous media obtained from X ray CAT scans. The medial axis is constructed during an iterative erosion procedure which, at each step, replaces the image of the void structure with a smaller version obtained by eroding its surface layer of voxels. The algorithm is applied to high (5 mu m) resolution microtomographic images of two rock chips (Berea sandstone and Danish chalk) and a sample of uniform (100 mu m) diameter, packed glass beads. We statistically investigate several geometrical properties of the structure of the medial axes obtained. The first is the distribution of relative volumes in each erosion layer of the void space. We find the distributions to be exponential for the two real rock samples and normal for the packed glass beads. The second property investigated is the distribution of volumes of disconnected segments of the medial axis which are in one-to-one correspondence with disconnected void segments of the sample. We find indications for a universal power law behavior governing the distribution of volumes of the smallest disconnected pieces. The final behavior studied is a geometric tortuosity as measured by shortest paths through the medial axis. This tortuosity distribution appears well described by a gamma distribution. Copyright 1996 by the American Geophysical Union. JF - Journal of Geophysical Research AU - Lindquist, W Brent AU - Lee, Sang-Moon AU - Coker, David A AU - Jones, Keith W AU - Spanne, Per Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 8297 EP - 8310 PB - American Geophysical Union, Washington, DC VL - 101 IS - B4 SN - 0148-0227, 0148-0227 KW - tomography KW - imagery KW - numerical models KW - three-dimensional models KW - Paleozoic KW - Berea Sandstone KW - tortuosity KW - porous materials KW - porosity KW - geometry KW - physical properties KW - X-ray data KW - medial axis method KW - algorithms KW - computed tomography data KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50179187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Media+axis+analysis+of+void+structure+in+three-dimensional+tomographic+images+of+porous+media&rft.au=Lindquist%2C+W+Brent%3BLee%2C+Sang-Moon%3BCoker%2C+David+A%3BJones%2C+Keith+W%3BSpanne%2C+Per&rft.aulast=Lindquist&rft.aufirst=W&rft.date=1996-04-01&rft.volume=101&rft.issue=B4&rft.spage=8297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F95JB03039 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 42 N1 - PubXState - DC N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - algorithms; Berea Sandstone; computed tomography data; geometry; imagery; medial axis method; numerical models; Paleozoic; physical properties; porosity; porous materials; three-dimensional models; tomography; tortuosity; X-ray data DO - http://dx.doi.org/10.1029/95JB03039 ER - TY - JOUR T1 - Cocaine uptake is decreased in the brain of detoxified cocaine abusers. AN - 78445957; 8866699 AB - Binding of [11C]cocaine in brain was measured with positron emission tomography in 12 detoxified cocaine abusers and in 20 controls to evaluate if there were changes in cocaine binding and in dopamine (DA) transporter availability associated with chronic cocaine use. Nine controls and 10 cocaine abusers had an additional scan with [18F]N-methylspiroperidol to measure dopamine D2 receptors. Cocaine abusers had significantly lower uptake of [11C]cocaine in brain (6.2 +/- 1% dose/cc tissues) than controls (7.7 +/- 2%). The distribution volumes (DV) for [11C]cocaine were reduced in basal ganglia (BG), cortex, thalamus, and cerebellum (CB) of cocaine abusers. However there were no differences in the ratio of the DV in BG to that in CB, which is an estimate of DA transporter availability. Values for DA D2 receptor availability were decreased in cocaine abusers and did not correlate with estimates of dopamine transporter availability. In summary, detoxified cocaine abusers showed decreased uptake of cocaine in brain but did not show changes in DA transporter availability. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Volkow, N D AU - Wang, G J AU - Fowler, J S AU - Logan, J AU - Hitzemannn, R AU - Gatley, S J AU - MacGregor, R R AU - Wolf, A P AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996/03// PY - 1996 DA - March 1996 SP - 159 EP - 168 VL - 14 IS - 3 SN - 0893-133X, 0893-133X KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Kinetics KW - Humans KW - Binding, Competitive KW - Adult KW - Tomography, Emission-Computed KW - Radioligand Assay KW - Basal Ganglia -- diagnostic imaging KW - Time Factors KW - Male KW - Basal Ganglia -- metabolism KW - Opioid-Related Disorders -- metabolism KW - Brain -- metabolism KW - Cocaine -- metabolism KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78445957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Cocaine+uptake+is+decreased+in+the+brain+of+detoxified+cocaine+abusers.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BFowler%2C+J+S%3BLogan%2C+J%3BHitzemannn%2C+R%3BGatley%2C+S+J%3BMacGregor%2C+R+R%3BWolf%2C+A+P&rft.aulast=Volkow&rft.aufirst=N&rft.date=1996-03-01&rft.volume=14&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-03 N1 - Date created - 1996-12-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Atomic weights; from a constant of nature to natural variations AN - 52674794; 1997-062770 AB - The concept of Atomic Weight of an element as a constant of nature has played a key role in science for almost two hundred years. Two centuries ago, it helped provide credence to the atomic theory of matter. One hundred fifty years ago, the periodicity in the properties of various elements as a function of their atomic weight helped lead to the discovery of the Periodic Table and the classification of the chemical elements. Early in this present century this constant of nature concept was shaken when elements were found, which had different atomic weight values as well as different radioactive properties but they had the same chemical properties and therefore were located in the same position in the Periodic Table. To solve this problem, the concept of isotopes was born. Finally fifty years ago, the variation in nature of the composition of the stable isotopes in carbon and oxygen was found, which led to a variation in their respective atomic weights. Now mass dependent chemical reactions, nuclear reactions both natural or man-made and radioactive decay processes force us to accept the idea that atomic weights are more likely to vary in nature than they are to be constants of nature. What should we expect from atomic weights in the future? JF - Journal of the Royal Society of Western Australia AU - Holden, N E A2 - Withers, Philip C. A2 - Rosman, Kevin J. R. Y1 - 1996/03// PY - 1996 DA - March 1996 SP - 21 EP - 25 PB - Royal Society of Western Australia, Perth, West. Aust. VL - 79, Part 1 SN - 0035-922X, 0035-922X KW - chemical elements KW - radioactive isotopes KW - periodic table KW - isotopes KW - atomic weight KW - geochemistry KW - variations KW - measurement KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52674794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Society+of+Western+Australia&rft.atitle=Atomic+weights%3B+from+a+constant+of+nature+to+natural+variations&rft.au=Holden%2C+N+E&rft.aulast=Holden&rft.aufirst=N&rft.date=1996-03-01&rft.volume=79%2C+Part+1&rft.issue=&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Society+of+Western+Australia&rft.issn=0035922X&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - de Laeter symposium on Isotope science N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 30 N1 - PubXState - West. Aust. N1 - Document feature - 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - JRSUAU N1 - SubjectsTermNotLitGenreText - atomic weight; chemical elements; geochemistry; isotopes; measurement; periodic table; radioactive isotopes; variations ER - TY - JOUR T1 - The past, present, and future of CO (sub 2) -coulometry for the measurement of carbon dioxide in natural waters AN - 52523087; 1999-008696 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Johnson, K M AU - Che, G AU - Wills, K Y1 - 1996/03// PY - 1996 DA - March 1996 PB - American Chemical Society, Washington, DC VL - 211 SN - 0065-7727, 0065-7727 KW - methods KW - water quality KW - concentration KW - ice cores KW - chemical analysis KW - sea water KW - coulometry KW - solutes KW - hydrochemistry KW - measurement KW - carbon dioxide KW - applications KW - chemical composition KW - geochemistry KW - accuracy KW - pore water KW - 02B:Hydrochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52523087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=The+past%2C+present%2C+and+future+of+CO+%28sub+2%29+-coulometry+for+the+measurement+of+carbon+dioxide+in+natural+waters&rft.au=Johnson%2C+K+M%3BChe%2C+G%3BWills%2C+K&rft.aulast=Johnson&rft.aufirst=K&rft.date=1996-03-01&rft.volume=211&rft.issue=&rft.spage=GEOC+021&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 211th ACS national meeting N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - PubXState - DC N1 - Last updated - 2014-03-14 N1 - SubjectsTermNotLitGenreText - accuracy; applications; carbon dioxide; chemical analysis; chemical composition; concentration; coulometry; geochemistry; hydrochemistry; ice cores; measurement; methods; pore water; sea water; solutes; water quality ER - TY - JOUR T1 - Abiotic pathways of thiosulfate transformations in marine sediments AN - 52518155; 1999-008758 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Vairavamurthy, Murthy A AU - Wang, S AU - Khandelwal, B AU - Manowitz, B A2 - Oteyza, Julian Y1 - 1996/03// PY - 1996 DA - March 1996 PB - American Chemical Society, Washington, DC VL - 211 SN - 0065-7727, 0065-7727 KW - sulfates KW - biochemistry KW - models KW - organic compounds KW - marine sediments KW - biogenic processes KW - chemical reactions KW - bacteria KW - thiosulfate KW - sediments KW - pyrite KW - reduction KW - sulfides KW - geochemistry KW - Eh KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52518155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Abiotic+pathways+of+thiosulfate+transformations+in+marine+sediments&rft.au=Vairavamurthy%2C+Murthy+A%3BWang%2C+S%3BKhandelwal%2C+B%3BManowitz%2C+B&rft.aulast=Vairavamurthy&rft.aufirst=Murthy&rft.date=1996-03-01&rft.volume=211&rft.issue=&rft.spage=GEOC+082&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 211th ACS national meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bacteria; biochemistry; biogenic processes; chemical reactions; Eh; geochemistry; marine sediments; models; organic compounds; pyrite; reduction; sediments; sulfates; sulfides; thiosulfate ER - TY - JOUR T1 - Monitoring the kinetics of metal surface precipitate formation using X-ray absorption fine structure (XAFS) spectroscopy AN - 52517551; 1999-008762 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Scheidegger, Andre M AU - Sparks, Donald L AU - Lamble, Geraldine M Y1 - 1996/03// PY - 1996 DA - March 1996 PB - American Chemical Society, Washington, DC VL - 211 SN - 0065-7727, 0065-7727 KW - silicates KW - sorption KW - monitoring KW - pyrophyllite KW - in situ KW - microstructure KW - atomic absorption spectra KW - X-ray spectra KW - absorption KW - chemical reactions KW - time factor KW - precipitation KW - metals KW - nickel KW - chemical properties KW - sheet silicates KW - spectra KW - kinetics KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52517551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Monitoring+the+kinetics+of+metal+surface+precipitate+formation+using+X-ray+absorption+fine+structure+%28XAFS%29+spectroscopy&rft.au=Scheidegger%2C+Andre+M%3BSparks%2C+Donald+L%3BLamble%2C+Geraldine+M&rft.aulast=Scheidegger&rft.aufirst=Andre&rft.date=1996-03-01&rft.volume=211&rft.issue=&rft.spage=GEOC+086&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 211th ACS national meeting N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - PubXState - DC N1 - Last updated - 2014-03-14 N1 - SubjectsTermNotLitGenreText - absorption; atomic absorption spectra; chemical properties; chemical reactions; in situ; kinetics; metals; microstructure; monitoring; nickel; precipitation; pyrophyllite; sheet silicates; silicates; sorption; spectra; time factor; X-ray spectra ER - TY - JOUR T1 - Distribution of 3-mercaptopropionate in salt-marsh sediments from Shelter Island, New York AN - 51317273; 1999-008720 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Vairavamurthy, Murthy A AU - Khandelwal, B AU - Manowitz, B A2 - Oteyza, Julian Y1 - 1996/03// PY - 1996 DA - March 1996 PB - American Chemical Society, Washington, DC VL - 211 SN - 0065-7727, 0065-7727 KW - United States KW - Monocotyledoneae KW - Spermatophyta KW - mercaptopropionate KW - vegetation KW - Suffolk County New York KW - spatial distribution KW - chemical reactions KW - sediments KW - Spartina KW - chemical composition KW - geochemistry KW - Spartina alterniflora KW - concentration KW - Plantae KW - marshes KW - biochemistry KW - New York KW - mires KW - biogenic processes KW - salt marshes KW - Shelter Island KW - bacteria KW - Gramineae KW - Angiospermae KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51317273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Distribution+of+3-mercaptopropionate+in+salt-marsh+sediments+from+Shelter+Island%2C+New+York&rft.au=Vairavamurthy%2C+Murthy+A%3BKhandelwal%2C+B%3BManowitz%2C+B&rft.aulast=Vairavamurthy&rft.aufirst=Murthy&rft.date=1996-03-01&rft.volume=211&rft.issue=&rft.spage=GEOC+044&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 211th ACS national meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Angiospermae; bacteria; biochemistry; biogenic processes; chemical composition; chemical reactions; concentration; geochemistry; Gramineae; marshes; mercaptopropionate; mires; Monocotyledoneae; New York; Plantae; salt marshes; sediments; Shelter Island; Spartina; Spartina alterniflora; spatial distribution; Spermatophyta; Suffolk County New York; United States; vegetation ER - TY - JOUR T1 - N-ras mutations in radiation-induced murine leukemic cells. AN - 78711253; 9075579 AB - N-ras mutations were examined in DNA samples extracted from the spleen of CBA/Ca mice that developed myeloid leukemia (ML) following exposure to radiations of different qualities. A total of 17 ML cases, i.e. 5 cases of neutron-induced and 12 cases of photon- (3 gamma-ray and 9 x-ray) induced ML were included in the study along with 12 DNA samples from the bone marrow cells of control mice. Polymerase chain reaction-single strand conformational polymorphisms (PCR-SSCP) and the direct sequencing of PCR products were used to analyze three regions of the N-ras gene: (i) a 120 base-pair (bp) long portion of exon I (codons 2-37); (ii) a 103 bp long portion of exon II (codons 48-82); and (iii) a 107 bp long portion of exon III (codons 118-150). PCR-SSCP mobility shifts indicated mutations within only exon II of the N-ras gene. Such mutations were more prevalent in samples from mice exposed to fast neutrons. The exact type and location of these mutations were then determined by direct DNA sequencing. Silent point mutations, i.e. base transitions at the third base of codons 57 (GAC-->GAT), 62 (CAA-->CAC), or 70 (CAG-->CAA) were present only in mice that developed ML after exposure to fast neutrons. A base transversion at the third base of codon 61 (CAA-->CAC) was also observed in some ML cases. DNA sequencing demonstrated that ML samples contained normal as well as mutated DNA sequences. The higher frequency of N-ras mutations in neutron-induced ML suggested that fast neutrons are more effective in inducing genomic instability at the N-ras region of the genome. More importantly, N-ras mutations are not the initiating event in radiation leukemogenesis. This conclusion was supported by the finding that N-ras mutations were detected only in mice with an overt leukemic phenotype but not in mice with minimal tissue infiltration of leukemic cells, suggesting that the disease may be present prior to the presence of N-ras mutations. Alternatively, N-ras may be present in these mice but a large number of normal spleen cells in these mice interferes with the detection of mutation in a small population of leukemic cells. JF - Blood cells, molecules & diseases AU - Rithidech, K N AU - Dunn, J J AU - Gordon, C R AU - Cronkite, E P AU - Bond, V P AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. rithidech@bnlarm.bnl.gov Y1 - 1996 PY - 1996 DA - 1996 SP - 271 EP - 280 VL - 22 IS - 3 SN - 1079-9796, 1079-9796 KW - Index Medicus KW - Polymerase Chain Reaction KW - Animals KW - Mice, Inbred CBA KW - Mice KW - Polymorphism, Single-Stranded Conformational KW - Male KW - Mutagenesis KW - Genes, ras -- genetics KW - Leukemia, Radiation-Induced -- genetics KW - Leukemia, Myeloid -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78711253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood+cells%2C+molecules+%26+diseases&rft.atitle=N-ras+mutations+in+radiation-induced+murine+leukemic+cells.&rft.au=Rithidech%2C+K+N%3BDunn%2C+J+J%3BGordon%2C+C+R%3BCronkite%2C+E+P%3BBond%2C+V+P&rft.aulast=Rithidech&rft.aufirst=K&rft.date=1996-01-01&rft.volume=22&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Blood+cells%2C+molecules+%26+diseases&rft.issn=10799796&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-02 N1 - Date created - 1997-06-02 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The biological effects of Auger electrons compared to alpha-particles and Li ions. AN - 78686900; 9004772 AB - The present study reports the results of V-79 Chinese hamster cell survival studies in which Auger electron emission was stimulated in gadolinium (Gd) after thermal neutron capture. When a porphyrin that had previously been labeled with boron (10BOPP) was also labeled with Gd (Gd-10BOPP), the cells were incubated with Gd-10BOPP to assess the compound's ability to physiologically transport the Gd into the cell, and localize the Gd atoms in or near the cell's critical target, presumably the DNA. It was anticipated that Auger electron emission, stimulated during the 157Gd (n, gamma)158Gd interaction, would impart additional high LET damage to that observed from the alpha-particle and Li ion during the 10B(n, alpha) 7Li reaction. Following irradiation with thermal neutrons from the Brookhaven Medical Research Reactor, the effectiveness of the Auger electrons was determined by comparing the response of cells incubated with 10BOPP, where damage was imparted by the boron neutron capture (BNC) products, to that from Gd-10BOPP, with equal concentration of 10B in both solutions. An Auger effectiveness factor of approximately 2 was found for the Gd-10BOPP cells. The Auger effectiveness observed with Gd strongly suggested that the 10BOPP molecule physiologically transported the Gd3+ ion intracellularly where it probably bound to DNA. Others have reported that Gd3+ does, in fact, complex with DNA. While depositing less energy per interaction than the high LET BNC reaction by-products, Auger electron ionization was more effective. JF - Acta oncologica (Stockholm, Sweden) AU - Laster, B H AU - Shani, G AU - Kahl, S B AU - Warkentien, L AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 917 EP - 923 VL - 35 IS - 7 SN - 0284-186X, 0284-186X KW - Porphyrins KW - 0 KW - Gadolinium KW - AU0V1LM3JT KW - Boron KW - N9E3X5056Q KW - Index Medicus KW - Space life sciences KW - Animals KW - Relative Biological Effectiveness KW - Porphyrins -- metabolism KW - Cell Line -- radiation effects KW - Cricetulus KW - Cell Line -- metabolism KW - Neutron Activation Analysis KW - Cell Survival -- radiation effects KW - Cricetinae KW - Gadolinium -- pharmacokinetics KW - Linear Energy Transfer KW - Boron -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78686900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.atitle=The+biological+effects+of+Auger+electrons+compared+to+alpha-particles+and+Li+ions.&rft.au=Laster%2C+B+H%3BShani%2C+G%3BKahl%2C+S+B%3BWarkentien%2C+L&rft.aulast=Laster&rft.aufirst=B&rft.date=1996-01-01&rft.volume=35&rft.issue=7&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.issn=0284186X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-30 N1 - Date created - 1997-01-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cocaine addiction: hypothesis derived from imaging studies with PET. AN - 78576300; 8943582 AB - Analysis of the behavior of cocaine in the human brain with Positron Emission Tomography reveals that it is not only its affinity for the dopamine transporter that gives it its unique properties but also its fast pharmacokinetics. Its very fast uptake and clearance from the brain contrast with that of methylphenidate, another drug that inhibits the DA transporter. Methylephenidate clears from the brain at a much slower rate and is less addictive than cocaine. We postulate that periodic and frequent stimulation of the dopaminergic system secondary to chronic use of cocaine favors activation of a circuit that involves the orbitofrontal cortex, cingulate gyrus, thalamus and striatum. This circuit is abnormal in cocaine abusers and we postulate that is activation by cocaine perpetuates the compulsive administration of the drug and is perceived by the cocaine abuser as a intense desire resulting in the loss of control over the drive to take more cocaine. JF - Journal of addictive diseases AU - Volkow, N D AU - Ding, Y S AU - Fowler, J S AU - Wang, G J AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 55 EP - 71 VL - 15 IS - 4 SN - 1055-0887, 1055-0887 KW - Carbon Radioisotopes KW - 0 KW - Dopamine Uptake Inhibitors KW - Receptors, Dopamine D2 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Papio KW - Animals KW - Positron-Emission Tomography KW - Methylphenidate -- pharmacology KW - Humans KW - Receptors, Dopamine D2 -- drug effects KW - Dopamine Uptake Inhibitors -- pharmacology KW - Cocaine -- pharmacokinetics KW - Brain -- metabolism KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Cocaine -- administration & dosage KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78576300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Cocaine+addiction%3A+hypothesis+derived+from+imaging+studies+with+PET.&rft.au=Volkow%2C+N+D%3BDing%2C+Y+S%3BFowler%2C+J+S%3BWang%2C+G+J&rft.aulast=Volkow&rft.aufirst=N&rft.date=1996-01-01&rft.volume=15&rft.issue=4&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-11 N1 - Date created - 1997-03-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cardiotoxic properties of cocaine: studies with positron emission tomography. AN - 78336448; 8809858 AB - This study documented marked accumulation of cocaine in the human and baboon heart, which was not inhibited by desipramine pretreatment. However, cocaine inhibited 6-[18F]fluoronorepinephrine uptake in heart to the same degree as did desipramine (Fowler et al. 1994). Since uptake of [18F]norepinephrine in the heart is a function of its uptake by the NE transporter (Fowler et al. 1994), its inhibition by cocaine corroborates in vivo a significant interaction of cocaine with this transporter. JF - NIDA research monograph AU - Volkow, N D AU - Fowler, J S AU - Ding, Y S AD - Clinical Research Center, Brookhaven National Laboratory, NY, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 159 EP - 174 VL - 163 SN - 1046-9516, 1046-9516 KW - Carrier Proteins KW - 0 KW - Narcotics KW - Norepinephrine Plasma Membrane Transport Proteins KW - SLC6A2 protein, human KW - Symporters KW - Cocaine KW - I5Y540LHVR KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Papio KW - Animals KW - Carrier Proteins -- metabolism KW - Norepinephrine -- metabolism KW - Humans KW - Adult KW - Tomography, Emission-Computed KW - Heart -- drug effects KW - Middle Aged KW - Myocardium -- metabolism KW - Heart Diseases -- chemically induced KW - Narcotics -- toxicity KW - Narcotics -- pharmacokinetics KW - Heart Diseases -- metabolism KW - Cocaine -- toxicity KW - Cocaine -- pharmacokinetics KW - Heart Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78336448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Cardiotoxic+properties+of+cocaine%3A+studies+with+positron+emission+tomography.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BDing%2C+Y+S&rft.aulast=Volkow&rft.aufirst=N&rft.date=1996-01-01&rft.volume=163&rft.issue=&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-10 N1 - Date created - 1996-12-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Mutagenesis and ultraviolet inactivation of transforming DNA of Haemophilus influenzae complexed with a Bacillus subtilis protein that alters DNA conformation. AN - 78307535; 8790716 AB - The wild-type Bacillus subtilis spore protein, SspCwt, binds to DNA in vitro and in vivo and changes the conformation of DNA from B to A. Synthesis of the cloned SspCwt gene in Escherichia coli also causes large increases in mutation frequency. Binding of SspCwt to transforming DNA from Haemophilus influenzae made the DNA resistant to ultraviolet (UV) radiation. The mutant protein, SspCala, which does not bind DNA, did not change the UV resistance. The UV sensitivity of the DNA/SspCwt complex was not increased when the recipients of the DNA were defective in excision of pyrimidine dimers. These data indicate that the H. influenzae excision mechanism does not operate on the spore photoproduct formed by UV irradiation of the complex. Selection for the streptomycin- or erythromycin-resistance markers on the transforming DNA evidenced significant mutations at loci closely linked to these, but not at other loci. SspCwt apparently entered the cell attached to the transforming DNA, and caused mutations in adjacent loci. The amount of such mutations decreased when the transforming DNA was UV irradiated, because UV unlinks linked markers. JF - Acta biochimica Polonica AU - Setlow, J K AU - Setlow, B C AU - Setlow, P AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 107 EP - 114 VL - 43 IS - 1 SN - 0001-527X, 0001-527X KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Proteins KW - DNA, Bacterial KW - Sigma Factor KW - Transcription Factors KW - spoIIR protein, Bacillus subtilis KW - spore-specific proteins, Bacillus KW - Index Medicus KW - Transformation, Bacterial KW - Kinetics KW - Drug Resistance, Microbial KW - Dose-Response Relationship, Radiation KW - Microbial Sensitivity Tests KW - Ultraviolet Rays KW - Haemophilus influenzae -- genetics KW - DNA, Bacterial -- chemistry KW - Bacterial Proteins -- metabolism KW - Anti-Bacterial Agents -- pharmacology KW - Haemophilus influenzae -- metabolism KW - Bacterial Proteins -- isolation & purification KW - DNA, Bacterial -- metabolism KW - Bacillus subtilis -- metabolism KW - Nucleic Acid Conformation KW - Haemophilus influenzae -- drug effects KW - DNA, Bacterial -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78307535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+biochimica+Polonica&rft.atitle=Mutagenesis+and+ultraviolet+inactivation+of+transforming+DNA+of+Haemophilus+influenzae+complexed+with+a+Bacillus+subtilis+protein+that+alters+DNA+conformation.&rft.au=Setlow%2C+J+K%3BSetlow%2C+B+C%3BSetlow%2C+P&rft.aulast=Setlow&rft.aufirst=J&rft.date=1996-01-01&rft.volume=43&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Acta+biochimica+Polonica&rft.issn=0001527X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-11-12 N1 - Date created - 1996-11-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Probabilistic assessment of health risks of methylmercury from burning coal. AN - 78298724; 8784831 AB - This paper describes a probabilistic assessment of neurological risks incurred from consuming fish containing methylmercury (MeHg), focusing on the incremental effects of Hg deposited from local coal combustion. A Monte Carlo model is used to simulate a "worst case" scenario in which a population of 5000 fish eaters in the upper midwestern United States derive the freshwater fish portion of their diet from local waters near a hypothetical large coal-fired power plant. This population is characterized by distributions of body mass, half-life of MeHg, and the ratios of blood to body burden and hair to blood MeHg. Each person's diet consists of varying amounts of tuna fish, freshwater sportfish, and marine fish and shellfish, the MeHg contents of which are characterized by national distribution statistics, as are the consumption rates for marine fish. The consumption rates for freshwater fish are specific to the region. The fish portion size is linked to body mass by a variable correlation. Each meal is assumed to be an independent sample; thus, as metabolic equilibrium is approached, each person's body burden of MeHg tends to approach the value corresponding to the mean MeHg intake for the population. Predictions of MeHg levels in hair by this model compared well with an observed distribution of 1437 women. Two neurological endpoints were examined: adult paresthesia, as related to MeHg body burden, and congenital neurological effects, as associated with average concentrations of MeHg in maternal hair during pregnancy. Two exposure scenarios are considered: a "baseline" in which the source of the mercury in fish is from background atmospheric deposition, and an "impact" scenario, in which local Hg deposition and concentrations in fish are roughly doubled to represent additional deposition from the hypothetical nearby power plant. For both scenarios, the 99th percentile of MeHg body burden was more than an order of magnitude below the lowest level at which increased transient adult paresthesia was experienced in an acute MeHg poisoning incident in Iraq. We thus conclude that neurological risks to adults from MeHg resulting from atmospheric Hg deposition are trivial. Based on three epidemiological studies of congenital neurological risks, we find that fetal effects appear to be more critical and that there is a smaller margin of safety for pregnant consumers of freshwater sportfish. However, the margin of safety is still considerable and may have been diminished by uncertainties in the relationships between maternal hair Hg and the actual fetal exposures. JF - Neurotoxicology AU - Lipfert, F W AU - Moskowitz, P D AU - Fthenakis, V AU - Saroff, L AD - Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 197 EP - 211 VL - 17 IS - 1 SN - 0161-813X, 0161-813X KW - Coal KW - 0 KW - Environmental Pollutants KW - Methylmercury Compounds KW - Index Medicus KW - Animals KW - Humans KW - Paresthesia -- chemically induced KW - Monte Carlo Method KW - Risk Assessment KW - Pregnancy KW - Central Nervous System Diseases -- chemically induced KW - No-Observed-Adverse-Effect Level KW - Fishes KW - Adult KW - Food Contamination KW - Midwestern United States KW - Female KW - Power Plants KW - Methylmercury Compounds -- adverse effects KW - Environmental Pollutants -- adverse effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78298724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Probabilistic+assessment+of+health+risks+of+methylmercury+from+burning+coal.&rft.au=Lipfert%2C+F+W%3BMoskowitz%2C+P+D%3BFthenakis%2C+V%3BSaroff%2C+L&rft.aulast=Lipfert&rft.aufirst=F&rft.date=1996-01-01&rft.volume=17&rft.issue=1&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-19 N1 - Date created - 1997-03-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Neurochemical mechanisms underlying responses to psychostimulants. AN - 78289639; 8784863 JF - NIDA research monograph AU - Volkow, N D AU - Fowler, J S AU - Hitzemann, R AU - Wang, G J AD - Clinical Research Center, Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 322 EP - 348 VL - 159 SN - 1046-9516, 1046-9516 KW - Dopamine Antagonists KW - 0 KW - Dopamine Uptake Inhibitors KW - Receptors, Dopamine KW - Salicylamides KW - Methylphenidate KW - 207ZZ9QZ49 KW - Raclopride KW - 430K3SOZ7G KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Receptors, Dopamine -- drug effects KW - Animals KW - Opioid-Related Disorders -- physiopathology KW - Humans KW - Opioid-Related Disorders -- etiology KW - Research Design KW - Brain -- physiopathology KW - Behavior -- drug effects KW - Dopamine Antagonists -- metabolism KW - Reward KW - Salicylamides -- metabolism KW - Dopamine Uptake Inhibitors -- metabolism KW - Methylphenidate -- metabolism KW - Substance-Related Disorders -- physiopathology KW - Brain Chemistry -- drug effects KW - Substance-Related Disorders -- etiology KW - Dopamine -- physiology KW - Dopamine -- metabolism KW - Substance-Related Disorders -- complications KW - Cocaine -- adverse effects KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78289639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Neurochemical+mechanisms+underlying+responses+to+psychostimulants.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BHitzemann%2C+R%3BWang%2C+G+J&rft.aulast=Volkow&rft.aufirst=N&rft.date=1996-01-01&rft.volume=159&rft.issue=&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-11-19 N1 - Date created - 1996-11-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Consideration of kinematic interaction in determining seismic responses of underground structures AN - 52765675; 1997-016158 AB - This paper investigates the effect of kinematic interaction on the seismic responses of underground structures through a parametric study. A buried concrete, cylindrical tank, typical of those found in DOE high-level waste sites, was analyzed for the seismic response using the computer program SASSI. The key response parameters were evaluated to identify the potential effects of kinematic interactions. The results of the study are presented in this paper. JF - BNL (Brookhaven National Laboratory) AU - Xu, J AU - Bandyopadhyay, K K AU - Miller, C A Y1 - 1996 PY - 1996 DA - 1996 SP - 5 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - soil mechanics KW - high-level waste KW - statistical analysis KW - mathematical models KW - seismic response KW - radioactive waste KW - kinematics KW - finite element analysis KW - soil-structure interface KW - safety KW - waste disposal KW - underground disposal KW - storage KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52765675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Xu%2C+J%3BBandyopadhyay%2C+K+K%3BMiller%2C+C+A&rft.aulast=Xu&rft.aufirst=J&rft.date=1996-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Consideration+of+kinematic+interaction+in+determining+seismic+responses+of+underground+structures&rft.title=Consideration+of+kinematic+interaction+in+determining+seismic+responses+of+underground+structures&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1997-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE96010691NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Presented at teh American Society of Mechanical Engineers (ASME) Pressure vessels and piping conference, Montreal, PQ, July 21-26, 1996; Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - finite element analysis; high-level waste; kinematics; mathematical models; radioactive waste; safety; seismic response; soil mechanics; soil-structure interface; statistical analysis; storage; underground disposal; waste disposal ER - TY - JOUR T1 - Anthropogenic halocarbon tracing of groundwater flow and CCl (sub 4) degradation in the saturated zone at Brookhaven National Laboratory AN - 52707476; 1997-041708 JF - Eos, Transactions, American Geophysical Union AU - Happell, J D AU - Wallace, D W R AU - Burke, T AU - Ramirez, R AU - Anonymous Y1 - 1996/01// PY - 1996 DA - January 1996 SP - 31 PB - American Geophysical Union, Washington, DC VL - 77 IS - 3, Suppl. SN - 0096-3941, 0096-3941 KW - wells KW - United States KW - chlorinated hydrocarbons KW - degradation KW - Brookhaven National Laboratory KW - observation wells KW - ground water KW - Suffolk County New York KW - southeastern New York KW - saturated zone KW - sampling KW - movement KW - tracers KW - halogenated hydrocarbons KW - Long Island KW - geochemistry KW - human activity KW - hydrochemistry KW - carbon tetrachloride KW - aquifers KW - recharge KW - organic compounds KW - New York KW - Upton New York KW - Magothy Aquifer KW - 02B:Hydrochemistry KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52707476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Anthropogenic+halocarbon+tracing+of+groundwater+flow+and+CCl+%28sub+4%29+degradation+in+the+saturated+zone+at+Brookhaven+National+Laboratory&rft.au=Happell%2C+J+D%3BWallace%2C+D+W+R%3BBurke%2C+T%3BRamirez%2C+R%3BAnonymous&rft.aulast=Happell&rft.aufirst=J&rft.date=1996-01-01&rft.volume=77&rft.issue=3%2C+Suppl.&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union; American Society of Limnology and Oceanography; 1996 ocean sciences meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - aquifers; Brookhaven National Laboratory; carbon tetrachloride; chlorinated hydrocarbons; degradation; geochemistry; ground water; halogenated hydrocarbons; human activity; hydrochemistry; Long Island; Magothy Aquifer; movement; New York; observation wells; organic compounds; recharge; sampling; saturated zone; southeastern New York; Suffolk County New York; tracers; United States; Upton New York; wells ER - TY - JOUR T1 - A high temperature neutron diffraction study of sodalite, Na (sub 4) Si (sub 3) Al (sub 3) O (sub 12) Cl; structure, ionic mobility and a possible phase transition above 1200 K AN - 52668255; 1997-075452 JF - Abstracts with Programs - Geological Society of America AU - McMullan, R K AU - Haga, N AU - Schomaker, Verner AU - Anonymous Y1 - 1996 PY - 1996 DA - 1996 SP - 101 PB - Geological Society of America (GSA), Boulder, CO VL - 28 IS - 7 SN - 0016-7592, 0016-7592 KW - silicates KW - chlorine KW - sodium ion KW - halogens KW - alkali metals KW - phase transitions KW - crystal structure KW - sodium KW - ions KW - temperature KW - chloride ion KW - metals KW - neutron diffraction data KW - sodalite group KW - framework silicates KW - sodalite KW - high temperature KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52668255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=A+high+temperature+neutron+diffraction+study+of+sodalite%2C+Na+%28sub+4%29+Si+%28sub+3%29+Al+%28sub+3%29+O+%28sub+12%29+Cl%3B+structure%2C+ionic+mobility+and+a+possible+phase+transition+above+1200+K&rft.au=McMullan%2C+R+K%3BHaga%2C+N%3BSchomaker%2C+Verner%3BAnonymous&rft.aulast=McMullan&rft.aufirst=R&rft.date=1996-01-01&rft.volume=28&rft.issue=7&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 28th annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 1997-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - alkali metals; chloride ion; chlorine; crystal structure; framework silicates; halogens; high temperature; ions; metals; neutron diffraction data; phase transitions; silicates; sodalite; sodalite group; sodium; sodium ion; temperature ER - TY - JOUR T1 - Brookhaven National Laboratory environmental monitoring plan for calendar year 1996 AN - 52657712; 1998-003012 AB - As required by DOE Order 5400.1, each U. S. Department of Energy (DOE) site, facility, or activity that uses, generates, releases, or manages significant quantities of hazardous materials shall provide a written Environmental Monitoring Plan (EMP) covering effluent monitoring and environmental surveillance. DOE/EH-0173T, Environmental Regulatory Guide for Radiological Effluent Monitoring and Environmental Surveillance, provides specific guidance regarding environmental monitoring activities. JF - BNL (Brookhaven National Laboratory) AU - Naidu, J R AU - Paquette, D AU - Lee, R Y1 - 1996 PY - 1996 DA - 1996 SP - 240 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - United States KW - hazardous waste KW - monitoring KW - Brookhaven National Laboratory KW - effluents KW - ecosystems KW - research KW - radioactive waste KW - ground water KW - Suffolk County New York KW - New York KW - planning KW - liquid waste KW - nuclear facilities KW - air KW - waste disposal KW - aquatic environment KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52657712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Naidu%2C+J+R%3BPaquette%2C+D%3BLee%2C+R&rft.aulast=Naidu&rft.aufirst=J&rft.date=1996-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Brookhaven+National+Laboratory+environmental+monitoring+plan+for+calendar+year+1996&rft.title=Brookhaven+National+Laboratory+environmental+monitoring+plan+for+calendar+year+1996&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1998-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE97000487NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - air; aquatic environment; Brookhaven National Laboratory; ecosystems; effluents; ground water; hazardous waste; liquid waste; monitoring; New York; nuclear facilities; planning; radioactive waste; research; Suffolk County New York; United States; waste disposal ER - TY - JOUR T1 - Confirmation of iron limitation of phytoplankton photosynthesis in the equatorial Pacific ocean AN - 13638582; 199702703 AB - The effect of iron enrichment on an open ocean low phytoplankton chlorophyll biomass was determined in the Pacific ocean in 1993. A single dose of soluble iron stimulated photosynthesis but no bloom was observed. A later experiment where the same dosage of iron was added but over 8 d resulted in a massive phytoplankton bloom and the significant reduction of available surface-water nutrients and carbon dioxide concentrations. In-situ measurements of fluorescence in the later experiment showed that biophysical alterations in the phytoplankton resulted in increased photosynthetic capability. JF - Nature AU - Behrenfeld, MJ AU - Bale, A J AU - Kolber, Z S AU - Aiken, J AU - Falkowski, P G AD - Brookhaven National Laboratory, New York Y1 - 1996 PY - 1996 DA - 1996 SP - 508 EP - 511 VL - 383 IS - 6600 SN - 0028-0836, 0028-0836 KW - Sea water (see also marine -----) KW - Surface water (s/a lakes,ponds,reservoirs,streams) KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13638582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Confirmation+of+iron+limitation+of+phytoplankton+photosynthesis+in+the+equatorial+Pacific+ocean&rft.au=Behrenfeld%2C+MJ%3BBale%2C+A+J%3BKolber%2C+Z+S%3BAiken%2C+J%3BFalkowski%2C+P+G&rft.aulast=Behrenfeld&rft.aufirst=MJ&rft.date=1996-01-01&rft.volume=383&rft.issue=6600&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Probabilistic risk assessment of nephrotoxic effect of uranium in drinking water. AN - 77691828; 7493805 AB - Assessments of the health effects of pollutants generally use models in which exposure variables and model parameters are point values, often chosen as conservative estimates. A more realistic approach is to characterize the uncertainty of each variable and parameter explicitly as a probability distribution. This paper presents a probabilistic version of an established model for metabolism of ingested uranium and characterizes the parameters of the model as distributions. It then characterizes the uncertainty of the threshold level for nephrotoxic risk of uranium, and uses distributions of the heterogeneity in drinking water intake of uranium in the U.S. to assess nephrotoxic risk. It further evaluates the implications of inadequate data on the heterogeneity of dietary intake. JF - Health physics AU - Morris, S C AU - Meinhold, A F AD - Biomedical and Environmental Assessment Group, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1995/12// PY - 1995 DA - December 1995 SP - 897 EP - 908 VL - 69 IS - 6 SN - 0017-9078, 0017-9078 KW - Water Pollutants, Radioactive KW - 0 KW - Uranium KW - 4OC371KSTK KW - Index Medicus KW - United States KW - Probability KW - Kinetics KW - Humans KW - Stochastic Processes KW - Models, Biological KW - Risk Assessment KW - Mathematics KW - Kidney -- radiation effects KW - Water Pollutants, Radioactive -- toxicity KW - Water Pollution, Radioactive KW - Kidney -- pathology KW - Water Supply KW - Uranium -- toxicity KW - Uranium -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77691828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Probabilistic+risk+assessment+of+nephrotoxic+effect+of+uranium+in+drinking+water.&rft.au=Morris%2C+S+C%3BMeinhold%2C+A+F&rft.aulast=Morris&rft.aufirst=S&rft.date=1995-12-01&rft.volume=69&rft.issue=6&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-01-05 N1 - Date created - 1996-01-05 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Erratum In: Health Phys 1998 Feb;74(2):274 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Comparative assessment of single-dose and fractionated boron neutron capture therapy. AN - 77691760; 7494875 AB - The effects of fractionating boron neutron capture therapy (BNCT) were evaluated in the intracerebral rat 9L gliosarcoma and rat spinal cord models using the Brookhaven Medical Research Reactor (BMRR) thermal neutron beam. The amino acid analog p-boronophenylalanine (BPA) was administered prior to each exposure to the thermal neutron beam. The total physical absorbed dose to the tumor during BNCT using BPA was 91% high-linear energy transfer (LET) radiation. Two tumor doses of 5.1 Gy spaced 48 h apart (n = 14) or three tumor doses of 5.2 Gy, each separated by 48 h (n = 10), produced 43 and 70% long-term (> 1 year) survivors, respectively [corrected]. The outcome of neither the two nor the three fractions of radiation was statistically different from that of the corresponding single-fraction group. In the rat spinal cord, the ED50 for radiation myelopathy (as indicated by limb paralysis within 7 months) after exposure to the thermal beam alone was 13.6 +/- 0.4 Gy. Dividing the beam-only irradiation into two or four consecutive daily fractions increased the ED50 to 14.7 +/- 0.2 Gy and 15.5 +/- 0.4 Gy, respectively. Thermal neutron irradiation in the presence of BPA resulted in an ED50 for myelopathy of 13.8 +/- 0.6 Gy after a single fraction and 14.9 +/- 0.9 Gy after two fractions. An increase in the number of fractions to four resulted in an ED50 of 14.3 +/- 0.6 Gy. The total physical absorbed dose to the blood in the vasculature of the spinal cord during BNCT using BPA was 80% high-LET radiation.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Radiation research AU - Coderre, J A AU - Morris, G M AU - Micca, P L AU - Fisher, C D AU - Ross, G A AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1995/12// PY - 1995 DA - December 1995 SP - 310 EP - 317 VL - 144 IS - 3 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Rats KW - Animals KW - Tumor Cells, Cultured KW - Radiotherapy Dosage KW - Dose-Response Relationship, Radiation KW - Time Factors KW - Cell Line KW - Spinal Cord Neoplasms -- radiotherapy KW - Brain Neoplasms -- radiotherapy KW - Boron Neutron Capture Therapy -- methods KW - Gliosarcoma -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77691760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Comparative+assessment+of+single-dose+and+fractionated+boron+neutron+capture+therapy.&rft.au=Coderre%2C+J+A%3BMorris%2C+G+M%3BMicca%2C+P+L%3BFisher%2C+C+D%3BRoss%2C+G+A&rft.aulast=Coderre&rft.aufirst=J&rft.date=1995-12-01&rft.volume=144&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-01-05 N1 - Date created - 1996-01-05 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Erratum In: Radiat Res 1996 Mar;145(3):388 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Stability and structure of new high-pressure silicate, Na (sub 1.8) Ca (sub 1.1) Si (sub 6) O (sub 14) AN - 50082033; 1996-012162 AB - Preliminary phase relations for the bulk composition Na (sub 2) OCaO5SiO (sub 2) were experimentally determined at 8-16 GPa and 950-2300 degrees C, using a split-sphere anvil apparatus. JF - American Mineralogist AU - Gasparik, Tibor AU - Parise, John B AU - Eiben, Bonnie A AU - Hriljac, Joseph A Y1 - 1995/12// PY - 1995 DA - December 1995 SP - 1269 EP - 1276 PB - Mineralogical Society of America, Washington, DC VL - 80 IS - 11-12 SN - 0003-004X, 0003-004X KW - silicates KW - experimental studies KW - pressure KW - X-ray diffraction data KW - stability KW - crystal structure KW - crystal growth KW - high pressure KW - electron probe data KW - polymorphism KW - phase equilibria KW - anvil cells KW - synthesis KW - P-T conditions KW - geophysics KW - 01B:Mineralogy of silicates KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50082033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Stability+and+structure+of+new+high-pressure+silicate%2C+Na+%28sub+1.8%29+Ca+%28sub+1.1%29+Si+%28sub+6%29+O+%28sub+14%29&rft.au=Gasparik%2C+Tibor%3BParise%2C+John+B%3BEiben%2C+Bonnie+A%3BHriljac%2C+Joseph+A&rft.aulast=Gasparik&rft.aufirst=Tibor&rft.date=1995-12-01&rft.volume=80&rft.issue=11-12&rft.spage=1269&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1996-01-01 N1 - Number of references - 18 N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - anvil cells; crystal growth; crystal structure; electron probe data; experimental studies; geophysics; high pressure; P-T conditions; phase equilibria; polymorphism; pressure; silicates; stability; synthesis; X-ray diffraction data ER - TY - JOUR T1 - Action spectroscopy in complex organisms: potentials and pitfalls in predicting the impact of increased environmental UVB. AN - 77827711; 8568602 AB - Evaluating the effects of broad spectrum sources, including sunlight, on humans and their environment requires knowledge both of the effects of various wavelengths of radiation in those sources on biological systems and of the kinds and magnitude of changes in those sources. Action spectroscopy-the determination of the effect of radiation on an organism as a function of wavelength-provides a major method for evaluating the effects of a source, including that of changes in its intensity and wavelength distribution. Although action spectra for UV radiation damage to higher organisms can give useful information, inappropriate analyses can lead to misleading or even incorrect results. It is thus essential to consider carefully methods of analyzing action spectra and their consequences for evaluating the effects of changes in the solar spectrum. JF - Journal of photochemistry and photobiology. B, Biology AU - Sutherland, B M AD - Biology Department, Brookhaven National Laboratory, Upon, NY 11973, USA. Y1 - 1995/11// PY - 1995 DA - November 1995 SP - 29 EP - 34 VL - 31 IS - 1-2 SN - 1011-1344, 1011-1344 KW - Pyrimidine Dimers KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Skin -- radiation effects KW - Humans KW - DNA -- radiation effects KW - Radiation Monitoring KW - Ultraviolet Rays KW - Spectrum Analysis -- methods KW - Radiation Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77827711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.atitle=Action+spectroscopy+in+complex+organisms%3A+potentials+and+pitfalls+in+predicting+the+impact+of+increased+environmental+UVB.&rft.au=Sutherland%2C+B+M&rft.aulast=Sutherland&rft.aufirst=B&rft.date=1995-11-01&rft.volume=31&rft.issue=1-2&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Journal+of+photochemistry+and+photobiology.+B%2C+Biology&rft.issn=10111344&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-03-07 N1 - Date created - 1996-03-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Assessment of plutonium exposures in Rongelap and Utirik populations by fission track analysis of urine. AN - 77690330; 8535424 AB - A nuclear device, code-named Bravo, detonated at Bikini Atoll at 6:45 a.m. on 1 March 1954, unexpectedly released a large amount of radioactivity. Over 40 years after this incident, the study of its impact on the radiological health and environmental safety of the residents of Rongelap and Utirik Atolls continues. In 1987, researchers at Brookhaven National Laboratory established a fission track analysis (FTA) method for low-level 239Pu urinalysis. Two years later, a new shipboard protocol was developed for collecting 24-h radiologically clean urine samples. The purpose of this paper is to update information on the FTA method for measuring low-levels of plutonium, and to summarize results on the distribution of 239Pu in the populations of Rongelap and Utirik between 1981-1991. Plutonium detection levels (99% confidence level) in these samples were 2-3 microBq, which is equivalent to 0.2-0.3 mSv effective dose equivalent (EDE) to age 70 for Marshallese. The latest 1991 FTA data indicate average EDE of 0.62 mSv and 1.6 mSv for the people of Rongelap and Utirik, respectively, which both are the highest values since 1988. JF - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine AU - Sun, L C AU - Moorthy, A R AU - Kaplan, E AU - Baum, J W AU - Meinhold, C B AD - Department of Advanced Technology, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1995/11// PY - 1995 DA - November 1995 SP - 1259 EP - 1269 VL - 46 IS - 11 SN - 0969-8043, 0969-8043 KW - Radioactive Fallout KW - 0 KW - Plutonium KW - 53023GN24M KW - Index Medicus KW - Urinalysis -- methods KW - Radiation Dosage KW - Body Burden KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Adult KW - Micronesia KW - Middle Aged KW - Adolescent KW - Time Factors KW - Female KW - Male KW - Plutonium -- urine KW - Radioactive Fallout -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77690330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+radiation+and+isotopes+%3A+including+data%2C+instrumentation+and+methods+for+use+in+agriculture%2C+industry+and+medicine&rft.atitle=Assessment+of+plutonium+exposures+in+Rongelap+and+Utirik+populations+by+fission+track+analysis+of+urine.&rft.au=Sun%2C+L+C%3BMoorthy%2C+A+R%3BKaplan%2C+E%3BBaum%2C+J+W%3BMeinhold%2C+C+B&rft.aulast=Sun&rft.aufirst=L&rft.date=1995-11-01&rft.volume=46&rft.issue=11&rft.spage=1259&rft.isbn=&rft.btitle=&rft.title=Applied+radiation+and+isotopes+%3A+including+data%2C+instrumentation+and+methods+for+use+in+agriculture%2C+industry+and+medicine&rft.issn=09698043&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-02-08 N1 - Date created - 1996-02-08 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Human exposure to toxic materials. The New York-New Jersey metropolitan region. AN - 77712699; 7500968 JF - The Mount Sinai journal of medicine, New York AU - Krishna, C R AU - Klein, R C AU - Jones, K W AU - Clesceri, N L AU - Stern, E A AD - Brookhaven Renselaer Environmental Partnership, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 1995/10// PY - 1995 DA - October 1995 SP - 375 EP - 379 VL - 62 IS - 5 SN - 0027-2507, 0027-2507 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - New York KW - Humans KW - New Jersey KW - Environmental Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77712699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.atitle=Human+exposure+to+toxic+materials.+The+New+York-New+Jersey+metropolitan+region.&rft.au=Krishna%2C+C+R%3BKlein%2C+R+C%3BJones%2C+K+W%3BClesceri%2C+N+L%3BStern%2C+E+A&rft.aulast=Krishna&rft.aufirst=C&rft.date=1995-10-01&rft.volume=62&rft.issue=5&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.issn=00272507&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-01-16 N1 - Date created - 1996-01-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Seismic design and evaluation guidelines for the Department of Energy high-level waste storage tanks and appurtenances AN - 52819781; 1996-051768 AB - This document provides seismic design and evaluation guidelines for underground high-level waste storage tanks. The guidelines reflect the knowledge acquired in the last two decades in defining seismic ground motion and calculating hydrodynamic loads, dynamic soil pressures and other loads for underground tank structures, piping and equipment. The application of the guidelines is illustrated with examples. The guidelines are developed for a specific design of underground storage tanks, namely double-shell structures. However, the methodology discussed is applicable for other types of tank structures as well. The application of these and of suitably adjusted versions of these concepts to other structural types will be addressed in a future version of this document. The original version of this document was published in January 1993. Since then, additional studies have been performed in several areas and the results are included in this revision. Comments received from the users are also addressed. Fundamental concepts supporting the basic seismic criteria contained in the original version have since then been incorporated and published in DOE-STD-1020-94 and its technical basis documents. This information has been deleted in the current revision. JF - BNL (Brookhaven National Laboratory) AU - Bandyopadhyay, K AU - Cornell, A AU - Costantino, C AU - Kennedy, R AU - Miller, C Y1 - 1995/10// PY - 1995 DA - October 1995 SP - 452 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - high-level waste KW - dynamic loading KW - loading KW - underground storage tanks KW - seismic response KW - pipelines KW - radioactive waste KW - safety KW - ground motion KW - waste disposal KW - earthquakes KW - underground disposal KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52819781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bandyopadhyay%2C+K%3BCornell%2C+A%3BCostantino%2C+C%3BKennedy%2C+R%3BMiller%2C+C&rft.aulast=Bandyopadhyay&rft.aufirst=K&rft.date=1995-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Seismic+design+and+evaluation+guidelines+for+the+Department+of+Energy+high-level+waste+storage+tanks+and+appurtenances&rft.title=Seismic+design+and+evaluation+guidelines+for+the+Department+of+Energy+high-level+waste+storage+tanks+and+appurtenances&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1996-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE96004058NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - design; dynamic loading; earthquakes; ground motion; high-level waste; loading; pipelines; radioactive waste; safety; seismic response; underground disposal; underground storage tanks; waste disposal ER - TY - JOUR T1 - Analysis of core samples from jet grouted soil AN - 52764679; 1997-001755 AB - Superplasticized cementitious grouts were tested for constructing subsurface containment barriers using jet grouting in July, 1994. The test site was located close to the Chemical Waste Landfill at Sandia National Laboratories, Albuquerque, NM. Sandia was responsible for the placement contract. The jet grouted soil was exposed to the service environment for one year and core samples were extracted to evaluate selected properties. The cores were tested for strength, density, permeability (hydraulic conductivity) and cementitious content. The tests provided an opportunity to determine the performance of the grouts and grout-treated soil. Several recommendations arise from the results of the core tests. These are: (1) grout of the same mix proportions as the final grout should be used as a drilling fluid in order to preserve the original mix design and utilize the benefits of superplasticizers; (2) a high shear mixer should be used for preparation of the grout; (3) the permeability under unsaturated conditions requires consideration when subsurface barriers are used in the vadose zone; and (4) suitable methods for characterizing the permeability of barriers in-situ should be applied. JF - BNL (Brookhaven National Laboratory) AU - Allan, M L AU - Kukacka, L E Y1 - 1995/10// PY - 1995 DA - October 1995 SP - 14 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - United States KW - Bernalillo County New Mexico KW - landfills KW - unsaturated zone KW - grouting KW - New Mexico KW - production KW - cores KW - remediation KW - fluid injection KW - materials KW - drilling KW - cement KW - plasticity KW - disposal barriers KW - sanitary landfills KW - soils KW - Sandia National Laboratories KW - soil mechanics KW - mechanical properties KW - physical properties KW - Albuquerque New Mexico KW - boreholes KW - testing KW - waste disposal KW - permeability KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52764679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Allan%2C+M+L%3BKukacka%2C+L+E&rft.aulast=Allan&rft.aufirst=M&rft.date=1995-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Analysis+of+core+samples+from+jet+grouted+soil&rft.title=Analysis+of+core+samples+from+jet+grouted+soil&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1997-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE96003671NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - Albuquerque New Mexico; Bernalillo County New Mexico; boreholes; cement; cores; disposal barriers; drilling; fluid injection; grouting; landfills; materials; mechanical properties; New Mexico; permeability; physical properties; plasticity; production; remediation; Sandia National Laboratories; sanitary landfills; soil mechanics; soils; testing; United States; unsaturated zone; waste disposal ER - TY - JOUR T1 - Distribution of moderately volatile trace elements in fine-grained chondrule rims in the unequilibrated CO3 chondrite, ALH A77307 AN - 50074184; 1996-008577 AB - Average elemental compositions are presented of these rims using a combination of EPMA and SXRF. The results show that matrix materials in this chondrule are enriched in moderately volatile elements relative to the bulk chondrite. The chondrules are not completely devoid of the volatile elements which is inconsistent with a simple two-component model. The relative depletions and enrichments in bulk chondrule matrix abundance patterns are not complementary, with those for the matrix showing a relatively smooth depletion as a function of volatility, while the bulk chondrules do not. Volatility was significant in establishing the fractionation patterns in matrix and rims of this meteorite. TEM of matrix and rim shows that it consists of a highly unequilibrated assemblage of silicates, oxides, sulphides and sulphates which have had very different formation and thermal histories prior to accretion into the host meteorite. JF - Geochimica et Cosmochimica Acta AU - Brearley, Adrian J AU - Bajt, Sasa AU - Sutton, Steve R Y1 - 1995/10// PY - 1995 DA - October 1995 SP - 4307 EP - 4316 PB - Pergamon, Oxford VL - 59 IS - 20 SN - 0016-7037, 0016-7037 KW - stony meteorites KW - fines KW - carbonaceous chondrites KW - distribution KW - CO chondrites KW - meteorites KW - volatiles KW - Allan Hills Meteorites KW - chondrules KW - ALHA 77307 KW - trace elements KW - chondrites KW - chemical composition KW - 05B:Petrology of meteorites and tektites KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50074184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Distribution+of+moderately+volatile+trace+elements+in+fine-grained+chondrule+rims+in+the+unequilibrated+CO3+chondrite%2C+ALH+A77307&rft.au=Brearley%2C+Adrian+J%3BBajt%2C+Sasa%3BSutton%2C+Steve+R&rft.aulast=Brearley&rft.aufirst=Adrian&rft.date=1995-10-01&rft.volume=59&rft.issue=20&rft.spage=4307&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2F0016-7037%2895%2900249-Y L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1996-01-01 N1 - Number of references - 25 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - ALHA 77307; Allan Hills Meteorites; carbonaceous chondrites; chemical composition; chondrites; chondrules; CO chondrites; distribution; fines; meteorites; stony meteorites; trace elements; volatiles DO - http://dx.doi.org/10.1016/0016-7037(95)00249-Y ER - TY - JOUR T1 - Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler. AN - 77526729; 7568017 AB - Microplanar beam radiation therapy has been proposed to treat brain tumors by using a series of rapid exposures to an array of parallel x-ray beams, each beam having uniform microscopic thickness and macroscopic breadth (i.e., microplanar). Thirty-six rats were exposed head-on either to an upright 4-mm-high, 20- or 37-microns-wide beam or to a horizontal 7-mm-wide, 42-microns-high beam of mostly 32- to 126-keV, minimally divergent x-rays from the X17 wiggler at the National Synchrotron Light Source at Brookhaven National Laboratory. Parallel slices of the head, separated at either 75 or 200 microns on center, were exposed sequentially at 310-650 grays (Gy) per second until each skin-entrance absorbed dose reached 312, 625, 1250, 2500, 5000, or 10,000 Gy. The rats were euthanized 2 weeks or 1 month later. Two rats with 10,000-Gy-entrance slices developed brain tissue necrosis. All the other 10,000- and 5000-Gy-entrance slices and some of the 2500- and 1250-Gy-entrance slices showed loss of neuronal and astrocytic nuclei and their perikarya. No other kind of brain damage was evident histologically in any rat with entrance absorbed doses < or = 5000 Gy. Brain tissues in and between all the 312- and 625-Gy-entrance slices appeared normal. This unusual resistance to necrosis is central to the rationale of microplanar beam radiation therapy for brain tumors. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Slatkin, D N AU - Spanne, P AU - Dilmanian, F A AU - Gebbers, J O AU - Laissue, J A AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 1995/09/12/ PY - 1995 DA - 1995 Sep 12 SP - 8783 EP - 8787 VL - 92 IS - 19 SN - 0027-8424, 0027-8424 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Rats, Inbred F344 KW - Necrosis KW - Synchrotrons KW - Dose-Response Relationship, Radiation KW - Astrocytes -- pathology KW - Male KW - Female KW - Neurons -- pathology KW - X-Ray Therapy -- adverse effects KW - Cranial Irradiation -- adverse effects KW - Brain -- radiation effects KW - Brain -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77526729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Subacute+neuropathological+effects+of+microplanar+beams+of+x-rays+from+a+synchrotron+wiggler.&rft.au=Slatkin%2C+D+N%3BSpanne%2C+P%3BDilmanian%2C+F+A%3BGebbers%2C+J+O%3BLaissue%2C+J+A&rft.aulast=Slatkin&rft.aufirst=D&rft.date=1995-09-12&rft.volume=92&rft.issue=19&rft.spage=8783&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-10-23 N1 - Date created - 1995-10-23 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Int J Radiat Oncol Biol Phys. 1988 Apr;14(4):751-9 [3350731] Acta Chir Scand. 1968;134(8):585-95 [5713443] Radiat Res. 1992 Mar;129(3):290-6 [1542717] Radiology. 1992 Dec;185(3):653-60 [1438741] Radiat Res Suppl. 1967;7:258-64 [6058662] Acta Radiol Ther Phys Biol. 1963 Jun;1:147-68 [14051157] Acta Radiol Ther Phys Biol. 1974 Dec;13(6):512-34 [4219255] Int J Appl Radiat Isot. 1980 Nov;31(11):695-701 [7450908] Int J Radiat Oncol Biol Phys. 1982 Oct;8(10):1771-4 [7153089] Acta Radiol Suppl. 1983;365:58-64 [6433653] Int J Radiat Oncol Biol Phys. 1987 Feb;13(2):279-82 [3102416] Br J Radiol. 1987 Nov;60(719):1099-108 [3690151] Int J Radiat Oncol Biol Phys. 1988 Jan;14(1):115-26 [3275599] Med Phys. 1992 Nov-Dec;19(6):1395-400 [1461201] Cancer. 1993 Apr 15;71(8):2666-74 [8453590] Acta Chir Scand. 1951 Dec 13;102(4):316-9 [14914373] Proc Natl Acad Sci U S A. 1988 Jun;85(11):4020-4 [3375251] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Thin-film Photovoltaic Cells: Health and Environmental Issues in their Manufacture Use and Disposal AN - 1443373042; 18560123 AB - The large-scale manufacture of thin-film photovoltaic cells may present health and safety hazards if adequate precautions are not taken. In this paper, we examine the hazards associated with producing and using Si, CdTe and CIS thin-film photovoltaic modules. We focus especially on the potential of workers in manufacturing facilities to be exposed to chronic, low levels of Cd. Pertinent regulations are reviewed and control options are presented that can minimize the risks to workers. Also, we investigate occupational safety hazards and the associated engineering and administrative options related to using pyrophoric silane in making amorphous silicon cells. Finully, recycling and disposal options for spent photovoltaic modules are discussed. JF - Progress in Photovoltaics AU - Fthenakis, V M AU - Moskowitz, P D AD - Biomedical and Environmental Assessment Group, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1995/09// PY - 1995 DA - Sep 1995 SP - 295 EP - 306 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 3 IS - 5 SN - 1062-7995, 1062-7995 KW - Risk Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Manufacturing industry KW - Silicon KW - Safety engineering KW - Solar cells KW - Reviews KW - Cadmium KW - Risk reduction KW - Recycling KW - Waste management KW - ENA 03:Energy KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443373042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+Photovoltaics&rft.atitle=Thin-film+Photovoltaic+Cells%3A+Health+and+Environmental+Issues+in+their+Manufacture+Use+and+Disposal&rft.au=Fthenakis%2C+V+M%3BMoskowitz%2C+P+D&rft.aulast=Fthenakis&rft.aufirst=V&rft.date=1995-09-01&rft.volume=3&rft.issue=5&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Progress+in+Photovoltaics&rft.issn=10627995&rft_id=info:doi/10.1002%2Fpip.4670030504 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Manufacturing industry; Silicon; Safety engineering; Reviews; Solar cells; Cadmium; Risk reduction; Recycling; Waste management DO - http://dx.doi.org/10.1002/pip.4670030504 ER - TY - JOUR T1 - Complexity, contingency, and criticality AN - 1037237513; 2012-076556 AB - Complexity originates from the tendency of large dynamical systems to organize themselves into a critical state, with avalanches or "punctuations" of all sizes. In the critical state, events which would otherwise be uncoupled become correlated. The apparent, historical contingency in many sciences, including geology, biology, and economics, finds a natural interpretation as a self-organized critical phenomenon. These ideas are discussed in the context of simple mathematical models of sandpiles and biological evolution. Insights are gained not only from numerical simulations but also from rigorous mathematical analysis. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Bak, Per AU - Paczuski, Maya AU - Anderson, Philip W Y1 - 1995/07/18/ PY - 1995 DA - 1995 Jul 18 SP - 6689 EP - 6696 PB - National Academy of Sciences, Washington, DC VL - 92 IS - 15 SN - 0027-8424, 0027-8424 KW - hierarchies KW - power law KW - self-organization KW - complexity KW - criticality KW - theoretical studies KW - systems analysis KW - mass movements KW - self-organized criticality KW - probability KW - ecology KW - statistical analysis KW - Gutenberg-Richter relation KW - mathematical models KW - biologic evolution KW - equations KW - equilibrium KW - concepts KW - avalanches KW - sandpile paradigm KW - contingency KW - punctuated equilibria KW - mass extinctions KW - earthquakes KW - Bak-Sneppen model KW - 15:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037237513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Complexity%2C+contingency%2C+and+criticality&rft.au=Bak%2C+Per%3BPaczuski%2C+Maya%3BAnderson%2C+Philip+W&rft.aulast=Bak&rft.aufirst=Per&rft.date=1995-07-18&rft.volume=92&rft.issue=15&rft.spage=6689&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ L2 - http://www.pnas.org/content/92/15/6689.full.pdf http://www.pnas.org/ LA - English DB - GeoRef N1 - Conference title - Physics; the opening to complexity N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2012-01-01 N1 - Number of references - 39 N1 - PubXState - DC N1 - Document feature - illus. N1 - SuppNotes - Accessed on Feb. 6, 2012 N1 - Last updated - 2012-08-31 N1 - CODEN - PNASA6 N1 - SubjectsTermNotLitGenreText - avalanches; Bak-Sneppen model; biologic evolution; complexity; concepts; contingency; criticality; earthquakes; ecology; equations; equilibrium; Gutenberg-Richter relation; hierarchies; mass extinctions; mass movements; mathematical models; power law; probability; punctuated equilibria; sandpile paradigm; self-organization; self-organized criticality; statistical analysis; systems analysis; theoretical studies ER - TY - JOUR T1 - Isolation of transcriptionally active mutants of T7 RNA polymerase that do not support phage growth. AN - 77399383; 7608967 AB - Mutants of bacteriophage T7 RNA polymerase defective in functions other than transcription were sought by random chemical mutagenesis of the cloned gene and selection for inability to support the growth of a T7 mutant whose growth is dependent on T7 RNA polymerase supplied by the host cell. About half of the mutant clones appeared unable to make full-length T7 RNA polymerase, many of them producing a truncated protein. Among 116 mutants expressing full-length protein, two-thirds were severely impaired in transcription, but a surprisingly high one-third were able to direct significant transcription in vivo. Both types of mutation were distributed across much of the gene, as determined by a rapid genetic mapping procedure that allows the lethal mutation in each clone to be localized. One mutation (isolated twice) allowed normal gene expression but prevented the formation of mature ends of T7 DNA from concatemers, which normally happens during packaging into phage particles. Thirty-seven of the mutations appeared to increase the sensitivity of the polymerase to inhibition by T7 lysozyme; all were suppressed by mutations in the lysozyme gene, including one suppressor constructed to retain full amidase activity but to be unable to bind T7 RNA polymerase. The two lysozyme-hypersensitive polymerase mutants analyzed in detail showed premature cessation of transcription during infection. Early proteins and those late proteins specified by genes as far right in T7 DNA as genes 8-9 appeared to be produced normally, but expression of genes farther to the right was strongly depressed. DNA replication was depressed about 50% in one of these mutants and 90% in the other, even though the T7 replication proteins were made in normal amounts at the normal time. JF - Journal of molecular biology AU - Zhang, X AU - Studier, F W AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1995/07/07/ PY - 1995 DA - 1995 Jul 07 SP - 156 EP - 168 VL - 250 IS - 2 SN - 0022-2836, 0022-2836 KW - Viral Proteins KW - 0 KW - bacteriophage T7 RNA polymerase KW - EC 2.7.7.- KW - DNA-Directed RNA Polymerases KW - EC 2.7.7.6 KW - N-Acetylmuramoyl-L-alanine Amidase KW - EC 3.5.1.28 KW - Index Medicus KW - DNA Replication -- genetics KW - N-Acetylmuramoyl-L-alanine Amidase -- pharmacology KW - Genes, Viral -- genetics KW - DNA Mutational Analysis KW - Recombination, Genetic KW - Genes, Lethal -- genetics KW - Molecular Sequence Data KW - Gene Expression KW - Suppression, Genetic KW - Amino Acid Sequence KW - Virus Replication -- genetics KW - Bacteriophage T7 -- growth & development KW - DNA-Directed RNA Polymerases -- metabolism KW - Mutation -- genetics KW - DNA-Directed RNA Polymerases -- antagonists & inhibitors KW - Bacteriophage T7 -- genetics KW - Bacteriophage T7 -- enzymology KW - Transcription, Genetic -- physiology KW - DNA-Directed RNA Polymerases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77399383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Isolation+of+transcriptionally+active+mutants+of+T7+RNA+polymerase+that+do+not+support+phage+growth.&rft.au=Zhang%2C+X%3BStudier%2C+F+W&rft.aulast=Zhang&rft.aufirst=X&rft.date=1995-07-07&rft.volume=250&rft.issue=2&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-08-11 N1 - Date created - 1995-08-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Lethal and mutagenic actions of N-methyl-N'-nitro-N-nitrosoguanidine potentiated by oxidized glutathione, a seemingly harmless substance in the cellular environment. AN - 77377941; 7601826 AB - Both the lethal and the mutagenic actions of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on cells of Streptococcus pneumoniae were greatly potentiated by a component of yeast extract added to the cellular environment. This component was found to be an oxidation product of glutathione, glutathione disulfide (GSSG). At low concentrations in the medium, both GSSG and glutathione potentiated MNNG action, but at high concentrations, glutathione (and other sulfhydryl compounds) abolished the effect. Point mutations in a cellular gene conferred resistance to the potentiating effect, and they blocked uptake of either GSSG or glutathione into the cells as well. This gene apparently encodes a component of the system for glutathione transport in S. pneumoniae. The mechanism by which GSSG, an apparently innocuous substance in the environment, renders low levels of MNNG genotoxic and cytotoxic thus depends on its transport into the cell, where it is reduced by glutathione reductase and then activates intracellular MNNG. Also, it was observed that mutants of S. pneumoniae defective in DNA mismatch repair are more resistant to MNNG than are wild-type cells by a factor of 2.5. JF - Journal of bacteriology AU - Kumaresan, K R AU - Springhorn, S S AU - Lacks, S A AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1995/07// PY - 1995 DA - July 1995 SP - 3641 EP - 3646 VL - 177 IS - 13 SN - 0021-9193, 0021-9193 KW - Carrier Proteins KW - 0 KW - Cell Extracts KW - Mutagens KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - Glutathione KW - GAN16C9B8O KW - Glutathione Disulfide KW - ULW86O013H KW - Index Medicus KW - Oxidation-Reduction KW - Genes, Bacterial KW - Drug Interactions KW - Carrier Proteins -- metabolism KW - Dose-Response Relationship, Drug KW - Drug Resistance, Microbial KW - Biological Transport KW - Yeasts -- chemistry KW - Cell Extracts -- chemistry KW - Methylnitronitrosoguanidine -- toxicity KW - Glutathione -- metabolism KW - Methylnitronitrosoguanidine -- pharmacology KW - Mutagens -- toxicity KW - Mutagens -- pharmacology KW - Glutathione -- pharmacology KW - Streptococcus pneumoniae -- drug effects KW - Glutathione -- analogs & derivatives KW - Streptococcus pneumoniae -- genetics KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77377941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Lethal+and+mutagenic+actions+of+N-methyl-N%27-nitro-N-nitrosoguanidine+potentiated+by+oxidized+glutathione%2C+a+seemingly+harmless+substance+in+the+cellular+environment.&rft.au=Kumaresan%2C+K+R%3BSpringhorn%2C+S+S%3BLacks%2C+S+A&rft.aulast=Kumaresan&rft.aufirst=K&rft.date=1995-07-01&rft.volume=177&rft.issue=13&rft.spage=3641&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-08-04 N1 - Date created - 1995-08-04 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: J Biol Chem. 1986 Sep 25;261(27):12462-71 [3745200] Microbiol Rev. 1986 Jun;50(2):133-65 [3523187] J Bacteriol. 1987 Sep;169(9):4320-6 [3114239] Carcinogenesis. 1987 Oct;8(10):1531-5 [3652388] J Bacteriol. 1988 Jan;170(1):190-6 [3275608] J Bacteriol. 1988 Jan;170(1):197-202 [3275609] J Bacteriol. 1989 May;171(5):2278-86 [2468646] Science. 1989 Jul 14;245(4914):160-4 [2665076] J Bacteriol. 1991 Jan;173(1):283-90 [1987120] Carcinogenesis. 1991 May;12(5):847-53 [2029748] J Biol Chem. 1991 Jul 15;266(20):13147-52 [2071597] Am J Physiol. 1992 Jan;262(1 Pt 1):C104-10 [1531100] Cell. 1993 Dec 3;75(5):1027-38 [8252616] Cell. 1993 Dec 17;75(6):1215-25 [8261515] J Biol Chem. 1994 Apr 1;269(13):9397-400 [8144521] Z Vererbungsl. 1961;92:403-12 [14481497] Biochim Biophys Acta. 1960 Apr 22;39:508-18 [14413322] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6424-8 [8341649] Genetics. 1966 Jan;53(1):207-35 [4379022] Biochim Biophys Acta. 1968 Jan 29;155(1):114-20 [5647053] Nature. 1969 Jul 12;223(5202):206-7 [5791738] J Bacteriol. 1970 Feb;101(2):373-83 [4391801] Biochem J. 1970 Feb;116(4):693-707 [5435496] J Bacteriol. 1973 Apr;114(1):152-63 [4144589] Anal Biochem. 1976 Oct;75(2):674-5 [984420] Nature. 1982 Apr 29;296(5860):868-9 [7040986] Biochemistry. 1982 Mar 16;21(6):1162-9 [7041972] Cell. 1982 Dec;31(2 Pt 1):327-36 [6297760] J Bacteriol. 1984 Mar;157(3):934-6 [6321445] Nature. 1984 Mar 8-14;308(5955):201-3 [6322009] J Bacteriol. 1985 Jun;162(3):979-84 [3997786] Environ Mutagen. 1986;8(5):659-73 [3533525] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The meaning of linear dose-response relations, made evident by use of absorbed dose to the cell. AN - 77294157; 7759256 AB - Experimental evidence shows that if the probability of biological response is plotted against the absorbed dose from ionizing radiation, and if both dose and response are determined at the same level of biological organization (e.g., cell or organ-organism) the result appears as a sigmoid, medical-toxicological type of "dose-response" function when plotted using linear coordinates. However, if the biological response expressed at the cellular level is similarly plotted against the average absorbed dose expressed at the organ-organism level, a linearly proportional, "non-threshold" function is obtained. To explain this marked difference in curve shape, the absorbed dose at the organ level in terms of its meaning at the cellular level was examined, and both dose and response were put on the latter level. The result is consistent with the conclusion that absorbed dose at the organ-organism level can be treated, at the cellular level, as the product of two quantities: 1) the mean energy concentration or dose in a cell from a deposition event, i.e., "hit size" (the frequency-averaged specific energy in a reference cell target), and 2) the number of deposition events, or "hits," on the exposed cells. When the mean hit size for a given radiation remains constant, and the number of hits is increased, the total number of responses follows a linearly proportional "hit number response function." However, if the hit number is held constant or normalized to a given value, and the hit size is varied, the resulting probability of cell response again plots as the apparently sigmoid curve mentioned above, which has been termed the "hit size effectiveness function." With decreasing hit size, the probability of a cellular response appears to decrease asymptotically, and become indistinguishable from zero before zero dose is reached. It follows from this inherent relationship between the two kinds of functions that a sufficiently extensive set of data on a population of cells permits either type of function to be produced at will. These findings bear on the interpretation of the "linear, non threshold" hypothesis. JF - Health physics AU - Bond, V P AU - Benary, V AU - Sondhaus, C A AU - Feinendegen, L E AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1995/06// PY - 1995 DA - June 1995 SP - 786 EP - 792 VL - 68 IS - 6 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Plant Cells KW - Stochastic Processes KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Biophysical Phenomena KW - Plants -- radiation effects KW - Biophysics KW - Cells -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77294157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=The+meaning+of+linear+dose-response+relations%2C+made+evident+by+use+of+absorbed+dose+to+the+cell.&rft.au=Bond%2C+V+P%3BBenary%2C+V%3BSondhaus%2C+C+A%3BFeinendegen%2C+L+E&rft.aulast=Bond&rft.aufirst=V&rft.date=1995-06-01&rft.volume=68&rft.issue=6&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-06-29 N1 - Date created - 1995-06-29 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Erratum In: Health Phys 1995 Oct;69(4):590 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cytogenetics research in radiation biology. AN - 77533044; 7488943 AB - Radiation cytogenetics goes back approximately six decades and not only contributed to the earliest development of radiobiology, but continues to contribute today. Contributions on three levels are outlined here. Early contributions to radiobiological theory include the nature of dose-effect curves, dose-rate and fractionation effects, and linear energy transfer (LET) effects. Understanding of the roles of aberrations in endpoints such as cell killing, mutation and carcinogenesis have more recently contributed to unraveling mechanisms in these important radiobiological effects. Finally, the study of various details of classical radiation cytogenetics, such as half chromatid exchange or sister chromatid union, has contributed to our current understanding of cytogenetic phenomena on the molecular level. JF - Stem cells (Dayton, Ohio) AU - Bender, M A AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 172 EP - 181 VL - 13 Suppl 1 SN - 1066-5099, 1066-5099 KW - Index Medicus KW - History of medicine KW - Space life sciences KW - Animals KW - History, 20th Century KW - Neoplasms, Radiation-Induced -- etiology KW - DNA Damage KW - Humans KW - Neoplasms, Radiation-Induced -- genetics KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Research -- history KW - Cell Death -- radiation effects KW - Chromosome Aberrations KW - Linear Energy Transfer KW - Mutation KW - Cytogenetics -- history KW - Radiobiology -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77533044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+cells+%28Dayton%2C+Ohio%29&rft.atitle=Cytogenetics+research+in+radiation+biology.&rft.au=Bender%2C+M+A&rft.aulast=Bender&rft.aufirst=M&rft.date=1995-05-01&rft.volume=13+Suppl+1&rft.issue=&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Stem+cells+%28Dayton%2C+Ohio%29&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-01-04 N1 - Date created - 1996-01-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Medical effects of exposure of human beings to fallout radiation from a thermonuclear explosion. AN - 77526683; 7488968 AB - On March 1, 1954, after detonation of a thermonuclear device on Bikini atoll, an unexpected wind shift resulted in the deposition of radioactive fallout on inhabited atolls. The fallout radiation caused fleeting systemic effects, dose-dependent depression of hematopoiesis and skin burns primarily due to the beta ray component of the fission radionuclides. Within a few weeks, hematopoietic recovery was substantial but slight depression of blood counts was maintained for several years. One case of fatal acute myeloblastic leukemia developed in a boy receiving 1.9 Gy as an infant. Cretinism developed in two boys exposed as infants with estimated thyroidal dose in excess of 50 Gy. Chemical hypothyroidism was detected in several persons. Thyroid adenomas and cancer commenced appearance ten years after exposure and became a major long-term medical problem. There have been no late effects attributable to the beta burns 40 years after exposure. Internal contamination from ingestion and inhalation of radionuclides is detectable. The doses are comparable to background levels in the U.S. There is no detectible decrease in longevity of the exposed Marshallese compared to an unexposed Marshallese population. JF - Stem cells (Dayton, Ohio) AU - Cronkite, E P AU - Bond, V P AU - Conard, R A AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 49 EP - 57 VL - 13 Suppl 1 SN - 1066-5099, 1066-5099 KW - Radioactive Fallout KW - 0 KW - Index Medicus KW - Skin -- injuries KW - Radiation Dosage KW - Animals KW - Neoplasms, Radiation-Induced -- etiology KW - Hypothyroidism -- etiology KW - Hematopoiesis -- radiation effects KW - Body Burden KW - Humans KW - Leukemia, Radiation-Induced -- etiology KW - Infant, Newborn KW - Thyroid Neoplasms -- etiology KW - Child KW - Pregnancy KW - Burns -- etiology KW - Infant KW - Skin -- radiation effects KW - Leukemia, Myeloid, Acute -- etiology KW - Adult KW - Congenital Hypothyroidism -- etiology KW - Micronesia KW - Adolescent KW - Male KW - Female KW - Radioactive Fallout -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77526683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+cells+%28Dayton%2C+Ohio%29&rft.atitle=Medical+effects+of+exposure+of+human+beings+to+fallout+radiation+from+a+thermonuclear+explosion.&rft.au=Cronkite%2C+E+P%3BBond%2C+V+P%3BConard%2C+R+A&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1995-05-01&rft.volume=13+Suppl+1&rft.issue=&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Stem+cells+%28Dayton%2C+Ohio%29&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-01-04 N1 - Date created - 1996-01-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Dose, effect severity, and imparted energy in assessing biological effects. AN - 77524705; 7488948 AB - Because of the widespread efforts in cancer radioepidemiological studies to attach a value of absorbed dose to each exposed individual, the notion seems to have become prevalent that dose plays an essential role in the medical determination of the diagnosis and prognosis of the individual. This view is enhanced by the fact that, while the present quantities and units for radiological physics were developed in the context of the acute effects of large exposures to radiation, e.g., in radiotherapy where they still apply well, these same quantities and units have been used, without modification, to apply to cancer radioepidemiology in the context of low level irradiation. A principle purpose of the present communication is to show that, in medicine, dose plays a limited role even in the deterministic application of therapeutic agents, and that diagnosis and estimates of prognosis in medicine are based, not on dose, but on the severity of effect on, or damage to the organ or organs involved in a particular medical condition. Thus it is "going backward" to view estimates of the severity of effect, e.g., the fraction of cells with abnormalities, or killed, as a "biological dosimeter," rather than as a quantitative estimate of the severity of effect. The use of biological indicators is of maximum value in noncancerous disease or injury in which the severity of an effect causative for organ failure and a consequent quantal, e.g., a lethal response in the individual, can be measured with increasing accuracy by modern medical techniques.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Stem cells (Dayton, Ohio) AU - Bond, V P AD - Brookhaven National Laboratory, Medical Department, Upton, New York 11973-5000, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 21 EP - 29 VL - 13 Suppl 1 SN - 1066-5099, 1066-5099 KW - Index Medicus KW - Radiation Dosage KW - Animals KW - Neoplasms, Radiation-Induced -- etiology KW - Radioactive Hazard Release KW - Nuclear Warfare KW - Humans KW - Radiation Injuries, Experimental -- etiology KW - Mice KW - Cell Survival -- radiation effects KW - Radiation Injuries -- diagnosis KW - Hematopoietic Stem Cells -- radiation effects KW - Radiation Injuries -- etiology KW - Radiation Effects KW - Radiobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77524705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+cells+%28Dayton%2C+Ohio%29&rft.atitle=Dose%2C+effect+severity%2C+and+imparted+energy+in+assessing+biological+effects.&rft.au=Bond%2C+V+P&rft.aulast=Bond&rft.aufirst=V&rft.date=1995-05-01&rft.volume=13+Suppl+1&rft.issue=&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Stem+cells+%28Dayton%2C+Ohio%29&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-01-04 N1 - Date created - 1996-01-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Application of the HSEF to assessing radiation risks in the practice of radiation protection. AN - 77233727; 7730058 AB - The primary risk coefficients upon which exposure limits for radiation protection purposes are currently based are derived almost exclusively from cancer-induction data obtained from human populations exposed to radiations of low linear energy transfer. The question of higher linear energy transfer radiations is handled by means of quality factors derived from values for relative biological effectiveness obtained from animal data. However, the advent of microdosimetry has made it possible to establish hit size effectiveness functions from single-cell systems, both in vitro and in vivo. This type of function can substitute completely for the concept of relative biological effectiveness, Q and equivalent dose. A common basis for risk coefficients and the hit size effectiveness function lies in the fact that human cancers are monoclonal and thus single cell in origin. The present communication utilizes this common base as a means of extending the present low-linear energy transfer based risk coefficients to include carcinogenic responses from exposure in radiation fields of any one or mixed qualities, extending from the smallest to the largest linear energy transfers of practical consequence. In doing so, risks from ionizing radiations of any linear energy transfer may be predicted more accurately than at present. JF - Health physics AU - Bond, V P AU - Varma, M AU - Feinendegen, L E AU - Wuu, C S AU - Zaider, M AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 627 EP - 631 VL - 68 IS - 5 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Risk Factors KW - Humans KW - Models, Biological KW - Linear Energy Transfer KW - Technology, Radiologic KW - Biophysical Phenomena KW - Biophysics KW - Radiation Protection KW - Neoplasms, Radiation-Induced -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77233727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Application+of+the+HSEF+to+assessing+radiation+risks+in+the+practice+of+radiation+protection.&rft.au=Bond%2C+V+P%3BVarma%2C+M%3BFeinendegen%2C+L+E%3BWuu%2C+C+S%3BZaider%2C+M&rft.aulast=Bond&rft.aufirst=V&rft.date=1995-05-01&rft.volume=68&rft.issue=5&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-05-31 N1 - Date created - 1995-05-31 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Overview of research and development in subsurface fate and transport modeling AN - 52770837; 1997-001803 AB - The US Department of Energy is responsible for the remediation of over 450 different subsurface-contaminated sites. Contaminant plumes at these sites range in volume from several to millions of cubic yards. The concentration of contaminants also ranges over several orders of magnitude. Contaminants include hazardous wastes such as heavy metals and organic chemicals, radioactive waste including tritium, uranium, and thorium, and mixed waste, which is a combination of hazardous and radioactive wastes. The physical form of the contaminants includes solutes, nonaqueous phase liquids (NAPLs), and vapor phase contaminants such as volatilized organic chemicals and radon. The subject of contaminant fate and transport modeling is multi-disciplinary, involving hydrology, geology, microbiology, chemistry, applied mathematics, computer science, and other areas of expertise. It is an issue of great significance in the United States and around the world. As such, many organizations have substantial programs in this area. In gathering data to prepare this report, a survey was performed of research and development work that is funded by US government agencies to improve the understanding and mechanistic modeling of processes that control contaminant movement through subsurface systems. Government agencies which fund programs that contain fate and transport modeling components include the Environmental Protection Agency, Nuclear Regulatory Commission, Department of Agriculture, Department of Energy, National Science Foundation, Department of Defense, United States Geological Survey, and National Institutes of Health. JF - BNL (Brookhaven National Laboratory) AU - Sullivan, T M AU - Chehata, M Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 95 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - soils KW - U. S. Department of Energy KW - contaminant plumes KW - isotopes KW - site exploration KW - pollutants KW - government agencies KW - pollution KW - tritium KW - remediation KW - radioactive waste KW - radioactive isotopes KW - transport KW - metals KW - hydrogen KW - thorium KW - uranium KW - waste disposal KW - actinides KW - heavy metals KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52770837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sullivan%2C+T+M%3BChehata%2C+M&rft.aulast=Sullivan&rft.aufirst=T&rft.date=1995-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Overview+of+research+and+development+in+subsurface+fate+and+transport+modeling&rft.title=Overview+of+research+and+development+in+subsurface+fate+and+transport+modeling&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1997-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE95012459NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - actinides; contaminant plumes; government agencies; heavy metals; hydrogen; isotopes; metals; pollutants; pollution; radioactive isotopes; radioactive waste; remediation; site exploration; soils; thorium; transport; tritium; U. S. Department of Energy; uranium; waste disposal ER - TY - JOUR T1 - Regional brain metabolic response to lorazepam in subjects at risk for alcoholism. AN - 77422115; 7625590 AB - The mechanisms underlying the blunted response to alcohol administration observed in subjects at risk for alcoholism are poorly understood and may involve GABA-benzodiazepine receptors. The purpose of this study was to investigate if subjects at risk for alcoholism had abnormalities in brain GABA-benzodiazepine receptor function. This study measured the effects of 30 micrograms/kg (i.v.) of lorazepam, on regional brain glucose metabolism using positron emission tomography and 2-deoxy-2[18F]fluoro-D-glucose in subjects with a positive family history for alcoholism (FP) (n = 12) and compared their response with that of subjects with a negative family history for alcoholism (FN) (n = 21). At baseline, FP subjects showed lower cerebellar metabolism than FN. Lorazepam decreased whole-brain glucose metabolism, and FP subjects showed a similar response to FN in cortical and subcortical regions, but FP showed a blunted response in cerebellum. Lorazepam-induced changes in cerebellar metabolism correlated with its motor effects. The decreased cerebellar baseline metabolism in FP as well as the blunted cerebellar response to lorazepam challenge may reflect disrupted activity of benzodiazepine-GABA receptors in cerebellum. These changes could account for the decreased sensitivity to the motor effects of alcohol and benzodiazepines in FP subjects. JF - Alcoholism, clinical and experimental research AU - Volkow, N D AU - Wang, G J AU - Begleiter, H AU - Hitzemann, R AU - Pappas, N AU - Burr, G AU - Pascani, K AU - Wong, C AU - Fowler, J S AU - Wolf, A P AD - Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 510 EP - 516 VL - 19 IS - 2 SN - 0145-6008, 0145-6008 KW - Receptors, GABA KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Deoxyglucose KW - 9G2MP84A8W KW - Lorazepam KW - O26FZP769L KW - Index Medicus KW - Receptors, GABA -- drug effects KW - Brain Mapping KW - Risk Factors KW - Humans KW - Adult KW - Deoxyglucose -- analogs & derivatives KW - Tomography, Emission-Computed KW - Receptors, GABA -- physiology KW - Neuropsychological Tests KW - Male KW - Deoxyglucose -- metabolism KW - Brain -- physiopathology KW - Alcoholism -- diagnostic imaging KW - Energy Metabolism -- physiology KW - Energy Metabolism -- drug effects KW - Brain -- drug effects KW - Energy Metabolism -- genetics KW - Alcoholism -- physiopathology KW - Alcoholism -- genetics KW - Brain -- diagnostic imaging KW - Lorazepam -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77422115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Regional+brain+metabolic+response+to+lorazepam+in+subjects+at+risk+for+alcoholism.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BBegleiter%2C+H%3BHitzemann%2C+R%3BPappas%2C+N%3BBurr%2C+G%3BPascani%2C+K%3BWong%2C+C%3BFowler%2C+J+S%3BWolf%2C+A+P&rft.aulast=Volkow&rft.aufirst=N&rft.date=1995-04-01&rft.volume=19&rft.issue=2&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-08-29 N1 - Date created - 1995-08-29 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Mechanisms of biodegradation of metal-citrate complexes by Pseudomonas fluorescens. AN - 77221765; 7721690 AB - Biodegradation of metal-citrate complexes by Pseudomonas fluorescens depends on the nature of the complex formed between the metal and citric acid. Bidentate Fe(III)-, Ni-, and Zn-citrate complexes were readily biodegraded, but the tridentate Cd- and Cu-citrate, and U-citrate complexes were not. The biodegradation of Ni- and Zn-citrate commenced after an initial lag period; the former showed only partial (70%) degradation, whereas the latter was completely degraded. Uptake studies with 14C-labeled citric acid and metal-citrate complexes showed that cells grown in medium containing citric acid transported free citric acid at the rate of 28 nmol min-1 and Fe(III)-citrate at the rate of 12.6 nmol min-1 but not Cd-, Cu-, Ni-, U-, and Zn-citrate complexes. However, cells grown in medium containing Ni- or Zn-citrate transported both Ni- and Zn-citrate, suggesting the involvement of a common, inducible transport factor. Cell extracts degraded Fe(III)-, Ni-, U-, and Zn-citrate complexes in the following order: The cell extract did not degrade Cd- or Cu-citrate complexes. These results show that the biodegradation of the U-citrate complex was limited by the lack of transport inside the cell and that the tridentate Cd- and Cu-citrate complexes were neither transported inside the cell nor metabolized by the bacterium. JF - Journal of bacteriology AU - Joshi-Tope, G AU - Francis, A J AD - Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 1989 EP - 1993 VL - 177 IS - 8 SN - 0021-9193, 0021-9193 KW - Citrates KW - 0 KW - Ferric Compounds KW - Metals KW - Cadmium KW - 00BH33GNGH KW - Citric Acid KW - 2968PHW8QP KW - Uranium KW - 4OC371KSTK KW - ferric citrate KW - 63G354M39Z KW - Nickel KW - 7OV03QG267 KW - Index Medicus KW - Cadmium -- metabolism KW - Ferric Compounds -- metabolism KW - Uranium -- metabolism KW - Nickel -- metabolism KW - Biodegradation, Environmental KW - Adaptation, Physiological KW - Subcellular Fractions -- metabolism KW - Biological Transport, Active KW - Pseudomonas fluorescens -- growth & development KW - Citrates -- metabolism KW - Pseudomonas fluorescens -- metabolism KW - Metals -- metabolism KW - Citrates -- pharmacokinetics KW - Metals -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77221765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Mechanisms+of+biodegradation+of+metal-citrate+complexes+by+Pseudomonas+fluorescens.&rft.au=Joshi-Tope%2C+G%3BFrancis%2C+A+J&rft.aulast=Joshi-Tope&rft.aufirst=G&rft.date=1995-04-01&rft.volume=177&rft.issue=8&rft.spage=1989&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-05-19 N1 - Date created - 1995-05-19 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Biochemistry. 1966 Feb;5(2):467-77 [5942950] J Biol Chem. 1973 Feb 10;248(3):807-14 [4630854] Eur J Biochem. 1974 Jun 15;45(2):555-9 [4604430] Anal Biochem. 1976 May 7;72:248-54 [942051] Eur J Biochem. 1983 Jul 15;134(1):151-6 [6305655] Proc Natl Acad Sci U S A. 1983 Aug;80(15):4674-8 [6308639] J Biol Chem. 1983 Sep 25;258(18):11106-11 [6309830] J Biol Chem. 1985 Jun 10;260(11):6871-81 [2987236] J Bacteriol. 1988 Jan;170(1):234-8 [3335482] J Bacteriol. 1988 Sep;170(9):4188-93 [3410828] J Bacteriol. 1989 Feb;171(2):896-900 [2914875] Appl Environ Microbiol. 1989 Jun;55(6):1375-9 [2764560] Biochimie. 1989 Sep-Oct;71(9-10):1029-37 [2512994] J Bacteriol. 1990 Jun;172(6):3298-303 [2140566] Appl Environ Microbiol. 1991 Dec;57(12):3511-6 [1785926] Biochemistry. 1992 Mar 17;31(10):2735-48 [1547214] Curr Top Cell Regul. 1992;33:261-75 [1386801] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Identification of an immunologically important hypervariable domain of major outer surface protein A of Borrelia burgdorferi. AN - 77172095; 7890394 AB - The gene for the major outer surface protein A (OspA) from several clinically obtained strains of Borrelia burgdorferi, the cause of Lyme disease, has been cloned, sequenced, and expressed in Escherichia coli by using a T7-based expression system (J. J. Dunn, B. N. Lade, and A. G. Barbour, Protein Expr. Purif. 1:159-168, 1990). All of the OspAs have a single conserved tryptophan at residue 216 or, in some cases, 217; however, the region of the protein flanking the tryptophan is hypervariable, as determined by a moving-window population analysis of ospA from 15 European and North American isolates of B. burgdorferi. Epitope-mapping studies using chemically cleaved OspA and a TrpE-OspA fusion have indicated that this hypervariable region is important for immune recognition. Biophysical analysis, including fluorescence and circular dichroism spectroscopy, have indicated that the conserved tryptophan is buried in a hydrophobic environment. Polar amino acid side chains flanking the tryptophan are likely to be exposed to the hydrophilic solvent. The hypervariability of these solvent-exposed amino acid residues may contribute to the antigenic variation in OspA. To test this, we have performed site-directed mutagenesis to replace some of the potentially exposed amino acid side chains in the B31 protein with the analogous residues of a Borrelia garinii strain, K48. The altered proteins were then analyzed by Western blot (immunoblot) with monoclonal antibodies which bind OspA on the surface of the intact B31 spirochete. Our results indicate that specific amino acid changes near the tryptophan can abolish the reactivity of OspA to these monoclonal antibodies, which is an important consideration in the design of vaccines based on recombinant OspA. JF - Infection and immunity AU - McGrath, B C AU - Dunn, J J AU - Gorgone, G AU - Guttman, D AU - Dykhuizen, D AU - Luft, B J AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 1356 EP - 1361 VL - 63 IS - 4 SN - 0019-9567, 0019-9567 KW - ospA KW - Antibodies, Bacterial KW - 0 KW - Antibodies, Monoclonal KW - Antigens, Bacterial KW - Antigens, Surface KW - Bacterial Outer Membrane Proteins KW - Bacterial Vaccines KW - DNA Primers KW - Lipoproteins KW - OspA protein KW - Recombinant Proteins KW - Index Medicus KW - Protein Structure, Secondary KW - Antibodies, Bacterial -- immunology KW - Amino Acid Sequence KW - Structure-Activity Relationship KW - Antibodies, Monoclonal -- immunology KW - Mutagenesis, Site-Directed KW - Base Sequence KW - In Vitro Techniques KW - Molecular Sequence Data KW - Recombinant Proteins -- immunology KW - Epitope Mapping KW - DNA Primers -- chemistry KW - Borrelia burgdorferi Group -- immunology KW - Bacterial Outer Membrane Proteins -- immunology KW - Antigens, Bacterial -- immunology KW - Antigens, Bacterial -- chemistry KW - Antigens, Surface -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77172095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Identification+of+an+immunologically+important+hypervariable+domain+of+major+outer+surface+protein+A+of+Borrelia+burgdorferi.&rft.au=McGrath%2C+B+C%3BDunn%2C+J+J%3BGorgone%2C+G%3BGuttman%2C+D%3BDykhuizen%2C+D%3BLuft%2C+B+J&rft.aulast=McGrath&rft.aufirst=B&rft.date=1995-04-01&rft.volume=63&rft.issue=4&rft.spage=1356&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-04-20 N1 - Date created - 1995-04-20 N1 - Date revised - 2017-02-17 N1 - Gene symbol - ospA N1 - SuppNotes - Cited By: Infect Immun. 1983 Aug;41(2):795-804 [6192088] J Biol Chem. 1977 Jul 25;252(14):4976-80 [194900] Rheum Dis Clin North Am. 1989 Nov;15(4):727-34 [2685927] Methods Enzymol. 1990;185:60-89 [2199796] Science. 1990 Oct 26;250(4980):553-6 [2237407] Microbiol Rev. 1991 Mar;55(1):21-34 [2030671] Infect Immun. 1991 Jun;59(6):1911-5 [2037351] J Infect Dis. 1991 Jul;164(1):123-32 [1829104] J Immunol. 1991 Sep 15;147(6):1995-2000 [1716290] J Mol Evol. 1991 Nov;33(5):470-3 [1960744] Biochim Biophys Acta. 1992 Mar 27;1120(1):59-68 [1554741] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5418-21 [1608951] Protein Expr Purif. 1990 Nov;1(2):159-68 [2136237] Int J Syst Bacteriol. 1992 Jul;42(3):378-83 [1380285] Med Microbiol Immunol. 1992;181(4):191-207 [1279368] J Immunol. 1993 Jul 15;151(2):900-6 [8335917] Biochim Biophys Acta. 1993 Oct 6;1202(2):287-96 [7691186] Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10163-7 [8234271] J Clin Microbiol. 1993 Nov;31(11):2873-7 [8263170] Infect Immun. 1994 Nov;62(11):4929-37 [7927774] J Clin Invest. 1986 Oct;78(4):934-9 [3531237] Erratum In: Infect Immun 1995 Jun;63(6):2390 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Dynamical structure in paleoclimate data AN - 52826452; 1996-048026 JF - Technical Report - Interagency Ecological Study Program for the Sacramento-San Joaquin Estuary AU - Stewart, H Bruce A2 - Isaacs, Caroline M. A2 - Tharp, Vera L. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 55 EP - 66 PB - Interagency Ecological Studies Program for the Sacramento-San Joaquin Estuary, [Sacramento, CA] SN - 0740-8137, 0740-8137 KW - hydrology KW - chaos KW - global change KW - Europe KW - indicators KW - Fennoscandia KW - paleoclimatology KW - ice sheets KW - variations KW - evaluation KW - time scales KW - models KW - case studies KW - South America KW - tree rings KW - ice KW - time domain analysis KW - Quelccaya ice cap KW - Peru KW - glacial geology KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52826452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+-+Interagency+Ecological+Study+Program+for+the+Sacramento-San+Joaquin+Estuary&rft.atitle=Dynamical+structure+in+paleoclimate+data&rft.au=Stewart%2C+H+Bruce&rft.aulast=Stewart&rft.aufirst=H&rft.date=1995-04-01&rft.volume=&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Technical+Report+-+Interagency+Ecological+Study+Program+for+the+Sacramento-San+Joaquin+Estuary&rft.issn=07408137&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Eleventh annual Pacific climate workshop N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 16 N1 - PubXState - CA] N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - case studies; chaos; Europe; evaluation; Fennoscandia; glacial geology; global change; hydrology; ice; ice sheets; indicators; models; paleoclimatology; Peru; Quelccaya ice cap; South America; time domain analysis; time scales; tree rings; variations ER - TY - JOUR T1 - Synchrotron X-ray-fluorescence and laser-ablation ICP-MS microprobes; useful instruments for analysis of experimental run-products AN - 52444502; 1999-060119 AB - Both of these instruments have been found to be efficient for the accurate measurement of a large range of trace elements in natural and synthetic minerals and glasses. The lower limits of detection of the SXRFM for Rb, Sr, Y, Zr and Nb are approximately 5.5 ppm, with a precision of + or - 20 % relative; for LAM-ICP-MS, the lower detection limits are approximately 2 ppm, with a precision of + or - 10-15 % relative. Both instruments have been used to measure partition coefficients between a Ti-rich calcic amphibole and a Ti-rich basanitic quenched glass produced experimentally; similar values of D (sub Sr) and D (sub Y) and identical values of D (sub Zr) were obtained on both instruments. JF - The Canadian Mineralogist AU - Dalpe, Claude AU - Baker, Don R AU - Sutton, Steve R A2 - Hawthorne, Frank C. A2 - Martin, R. F. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 481 EP - 498 PB - Mineralogical Association of Canada, Ottawa, ON VL - 33, Part 2 SN - 0008-4476, 0008-4476 KW - silicates KW - chemical analysis KW - inductively coupled plasma methods KW - ablation KW - laser methods KW - X-ray fluorescence KW - amphibole group KW - mass spectroscopy KW - clinoamphibole KW - pargasite KW - partition coefficients KW - X-ray analysis KW - synchrotrons KW - spectroscopy KW - chain silicates KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52444502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Canadian+Mineralogist&rft.atitle=Synchrotron+X-ray-fluorescence+and+laser-ablation+ICP-MS+microprobes%3B+useful+instruments+for+analysis+of+experimental+run-products&rft.au=Dalpe%2C+Claude%3BBaker%2C+Don+R%3BSutton%2C+Steve+R&rft.aulast=Dalpe&rft.aufirst=Claude&rft.date=1995-04-01&rft.volume=33%2C+Part+2&rft.issue=&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=The+Canadian+Mineralogist&rft.issn=00084476&rft_id=info:doi/ L2 - http://www.mineralogicalassociation.ca/template/EJournal/ LA - English DB - GeoRef N1 - Conference title - Special session of the GAC-MAC annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1999-01-01 N1 - Number of references - 57 N1 - PubXState - ON N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - CODEN - CAMIA6 N1 - SubjectsTermNotLitGenreText - ablation; amphibole group; chain silicates; chemical analysis; clinoamphibole; inductively coupled plasma methods; laser methods; mass spectroscopy; pargasite; partition coefficients; silicates; spectroscopy; synchrotrons; X-ray analysis; X-ray fluorescence ER - TY - JOUR T1 - Serotonin 5-HT2 receptor availability in chronic cocaine abusers. AN - 77775208; 8614247 AB - Serotonin 5-HT2 receptor availability was evaluated in chronic cocaine abusers (n = 19) using positron emission tomography and F-18 N-methylspiperone and was compared to control subjects (n =19). 5-HT2 Receptor availability was measured in frontal, occipital, cingulate and orbitofrontal cortices using the ratio of the distribution volume in the region of interest to that in the cerebellum which is a function of Bmax/Kd. 5-HT2 Receptor availability was significantly higher in cingulate and orbitofrontal cortices than in other frontal regions or occipital cortex. The values were not different in normal subjects and cocaine abusers. These results did not show any changes in 5-HT2 receptor availability in cocaine abusers as compared to the control subjects. JF - Life sciences AU - Wang, G J AU - Volkow, N D AU - Logan, J AU - Fowler, J S AU - Schlyer, D AU - MacGregor, R R AU - Hitzemann, R J AU - Gjedde, A AU - Wolf, A P AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 1995/03/10/ PY - 1995 DA - 1995 Mar 10 SP - PL299 EP - PL303 VL - 56 IS - 16 SN - 0024-3205, 0024-3205 KW - Receptors, Serotonin KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Brain -- metabolism KW - Adolescent KW - Male KW - Substance-Related Disorders -- metabolism KW - Receptors, Serotonin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77775208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Serotonin+5-HT2+receptor+availability+in+chronic+cocaine+abusers.&rft.au=Wang%2C+G+J%3BVolkow%2C+N+D%3BLogan%2C+J%3BFowler%2C+J+S%3BSchlyer%2C+D%3BMacGregor%2C+R+R%3BHitzemann%2C+R+J%3BGjedde%2C+A%3BWolf%2C+A+P&rft.aulast=Wang&rft.aufirst=G&rft.date=1995-03-10&rft.volume=56&rft.issue=16&rft.spage=PL299&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-06-03 N1 - Date created - 1996-06-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Gold, electron microscopy, and cancer therapy. AN - 77571070; 8553020 AB - Radioactive gold has properties suitable for radiotherapy and can provide lethal irradiation to cells. If the gold is conjugated to a targeting molecule, such as an antibody, it may be possible to specifically deliver the dose to tumor cells. Various gold particles are possible candidates and include gold colloids with adsorption of antibodies or gold clusters with covalent attachment. Different sizes of gold particles are available and some may be preferred for certain situations. Problems with intravenous injection and in vivo delivery are numerous, and a more tractable application is the direct instillation into the urinary bladder of radiogold immunoconjugates to treat superficial bladder carcinoma. Preliminary studies indicate the feasibility of this approach. JF - Scanning microscopy AU - Hainfeld, J F AD - Brookhaven National Laboratory, Biology Dept., Upton, NY 11973, USA. Y1 - 1995/03// PY - 1995 DA - March 1995 SP - 239 EP - 54; discussion 254-6 VL - 9 IS - 1 SN - 0891-7035, 0891-7035 KW - Antibodies, Monoclonal KW - 0 KW - Gold Radioisotopes KW - Immunotoxins KW - Index Medicus KW - Animals KW - Humans KW - Microscopy, Electron KW - Urinary Bladder Neoplasms -- diagnosis KW - Gold Radioisotopes -- therapeutic use KW - Immunotoxins -- therapeutic use KW - Urinary Bladder Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77571070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scanning+microscopy&rft.atitle=Gold%2C+electron+microscopy%2C+and+cancer+therapy.&rft.au=Hainfeld%2C+J+F&rft.aulast=Hainfeld&rft.aufirst=J&rft.date=1995-03-01&rft.volume=9&rft.issue=1&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Scanning+microscopy&rft.issn=08917035&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-02-20 N1 - Date created - 1996-02-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Distribution of moderately volatile trace elements in fine-grained chondrule rims of metamorphosed CO3 chondrites AN - 52829987; 1996-049559 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Brearley, Adrian J AU - Bajt, Sasa AU - Sutton, Steve R AU - Blanchard, Douglas AU - Black, David Y1 - 1995/03// PY - 1995 DA - March 1995 SP - 169 EP - 170 PB - Lunar and Planetary Science Conference, Houston, TX VL - 26, Part 1 KW - CO chondrites KW - meteorites KW - Allan Hills Meteorites KW - stony meteorites KW - volatile elements KW - chondrules KW - ALHA 77307 KW - carbonaceous chondrites KW - trace elements KW - chondrites KW - chemical ratios KW - 05B:Petrology of meteorites and tektites KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52829987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Distribution+of+moderately+volatile+trace+elements+in+fine-grained+chondrule+rims+of+metamorphosed+CO3+chondrites&rft.au=Brearley%2C+Adrian+J%3BBajt%2C+Sasa%3BSutton%2C+Steve+R%3BBlanchard%2C+Douglas%3BBlack%2C+David&rft.aulast=Brearley&rft.aufirst=Adrian&rft.date=1995-03-01&rft.volume=26%2C+Part+1&rft.issue=&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-sixth lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 5 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - ALHA 77307; Allan Hills Meteorites; carbonaceous chondrites; chemical ratios; chondrites; chondrules; CO chondrites; meteorites; stony meteorites; trace elements; volatile elements ER - TY - JOUR T1 - Flash-heating of pyrrhotite from Orgueil (CI); evidence for the loss of sulphur and selenium during atmospheric entry heating of polar micrometeorites AN - 52825165; 1996-049729 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Greshake, A AU - Kloeck, W AU - Flynn, G J AU - Bajt, S AU - Bischoff, A AU - Blanchard, Douglas AU - Black, David Y1 - 1995/03// PY - 1995 DA - March 1995 SP - 511 EP - 512 PB - Lunar and Planetary Science Conference, Houston, TX VL - 26, Part 1 KW - CI chondrites KW - polar regions KW - experimental studies KW - stony meteorites KW - Orgueil Meteorite KW - selenium KW - carbonaceous chondrites KW - simulation KW - weathering KW - micrometeorites KW - meteorites KW - sulfur KW - oxides KW - chondrites KW - sulfides KW - pyrrhotite KW - magnetite KW - 05B:Petrology of meteorites and tektites KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52825165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Flash-heating+of+pyrrhotite+from+Orgueil+%28CI%29%3B+evidence+for+the+loss+of+sulphur+and+selenium+during+atmospheric+entry+heating+of+polar+micrometeorites&rft.au=Greshake%2C+A%3BKloeck%2C+W%3BFlynn%2C+G+J%3BBajt%2C+S%3BBischoff%2C+A%3BBlanchard%2C+Douglas%3BBlack%2C+David&rft.aulast=Greshake&rft.aufirst=A&rft.date=1995-03-01&rft.volume=26%2C+Part+1&rft.issue=&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-sixth lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 8 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - carbonaceous chondrites; chondrites; CI chondrites; experimental studies; magnetite; meteorites; micrometeorites; Orgueil Meteorite; oxides; polar regions; pyrrhotite; selenium; simulation; stony meteorites; sulfides; sulfur; weathering ER - TY - JOUR T1 - Hypermutability of mouse chromosome 2 during the development of x-ray-induced murine myeloid leukemia. AN - 77145117; 7862651 AB - In an effort to identify the precise role of a deletion at regions D-E of mouse chromosome 2 [del2(D-E)] during the development of radiation-induced myeloid leukemia, we conducted a serial sacrifice study in which metaphase chromosomes were examined by the G-banding technique. Such metaphase cells were collected from x-irradiated mice during the period of transformation of some of the normal hematopoietic cells to the fully developed leukemic phenotype. A group of 250 CBA/Ca male mice (10-12 weeks old) were exposed to a single dose of 2 Gy of 250-kilovolt-peak x-rays; 42 age-matched male mice served as controls. Groups of randomly selected mice were sacrificed at 20 hr, 1 week, and then at intervals of 3 months up to 24 months after x-irradiation. Slides for cytogenetic, hematological, and histological examination were prepared for each animal at each sacrifice time. An expansion of cells with lesions on one copy of chromosome 2 was evident in 20-25% of treated mice at each sacrifice time. The majority of such lesions were translocations at 2F or 2H, strongly suggesting hypermutability of these sites on mouse chromosome 2. No lesions were found in control mice. The finding leads to the possibility that genomic lesions close to 2D and 2E are aberrants associated with radiation leukemogenesis, whereas a single clone of cells with a del2(D-E) may lead directly to overt leukemia. The data also indicate that leukemic transformation arises from the cumulative effects of multiple genetic events on chromosome 2, reinforcing the thesis that multiple steps of mutation occur in the pathogenesis of cancer. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Rithidech, K AU - Bond, V P AU - Cronkite, E P AU - Thompson, M H AU - Bullis, J E AD - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY 11973-5000. Y1 - 1995/02/14/ PY - 1995 DA - 1995 Feb 14 SP - 1152 EP - 1156 VL - 92 IS - 4 SN - 0027-8424, 0027-8424 KW - Index Medicus KW - Animals KW - Mice, Inbred CBA KW - Mice KW - Male KW - Leukemia, Myeloid -- genetics KW - Chromosome Aberrations KW - Neoplasms, Radiation-Induced -- genetics KW - Leukemia, Myeloid -- etiology KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77145117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Hypermutability+of+mouse+chromosome+2+during+the+development+of+x-ray-induced+murine+myeloid+leukemia.&rft.au=Rithidech%2C+K%3BBond%2C+V+P%3BCronkite%2C+E+P%3BThompson%2C+M+H%3BBullis%2C+J+E&rft.aulast=Rithidech&rft.aufirst=K&rft.date=1995-02-14&rft.volume=92&rft.issue=4&rft.spage=1152&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-20 N1 - Date created - 1995-03-20 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Blood. 1976 May;47(5):705-21 [1260131] Nature. 1978 Mar 30;272(5652):455-6 [273147] Mutat Res. 1985 Jan-Feb;148(1-2):99-105 [3918259] Leukemia. 1988 Aug;2(8):545-50 [3166080] Biochem Biophys Res Commun. 1988 Nov 15;156(3):1265-70 [2903738] Chromosoma. 1994 Jun;103(3):186-92 [7924621] Genes Chromosomes Cancer. 1991 Sep;3(5):367-75 [1797084] Mamm Genome. 1992;3 Spec No:S20-43 [1498433] Int J Hematol. 1992 Aug;56(1):95-7 [1391810] Exp Hematol. 1993 Mar;21(3):427-31 [8440340] Trends Genet. 1989 Oct;5(10):326-31 [2692239] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Toxicological effects of ethanol on human health. AN - 77743038; 7576156 AB - Moderate ethanol consumption reduces stress and increases feelings of happiness and well-being, and may reduce the risk of coronary heart disease. Heavy consumption of alcohol, however, may cause addiction and increases all types of injury and trauma. Environmental and genetic factors are involved in susceptibility to alcoholism. Ethanol can lead to malnutrition, and can exert a direct toxicological effect due to its interference with hepatic metabolism and immunological functions. A causal effect has been observed between alcohol and various cancers. Cessation of alcohol consumption and balanced nutrition are recommended primary nonspecific therapeutic measures for alcoholics. Drug therapies for alcoholics suffering from liver injury has resulted in mixed results. In end-stage liver disease, liver transplantation may be considered. JF - Critical reviews in toxicology AU - Ahmed, F E AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1995 PY - 1995 DA - 1995 SP - 347 EP - 367 VL - 25 IS - 4 SN - 1040-8444, 1040-8444 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Humans KW - Alcohol Drinking -- adverse effects KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77743038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+toxicology&rft.atitle=Toxicological+effects+of+ethanol+on+human+health.&rft.au=Ahmed%2C+F+E&rft.aulast=Ahmed&rft.aufirst=F&rft.date=1995-01-01&rft.volume=25&rft.issue=4&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+toxicology&rft.issn=10408444&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-12-26 N1 - Date created - 1995-12-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Fractal dynamics of earthquakes AN - 52864599; 1996-019427 AB - Many objects in nature, from mountain landscapes to electrical breakdown and turbulence, have a self-similar fractal spatial structure. It seems obvious that to understand the origin of self-similar structures, one must understand the nature of the dynamical processes that created them: temporal and spatial properties must necessarily be completely interwoven. This is particularly true for earthquakes, which have a variety of fractal aspects. The distribution of energy released during earthquakes is given by the Gutenberg-Richter power law. The distribution of epicenters appears to be fractal with dimension D approx. 1-1.3. The number of after shocks decay as a function of time according to the Omori power law. There have been several attempts to explain the Gutenberg-Richter law by starting from a fractal distribution of faults or stresses. But this is a hen-and-egg approach: to explain the Gutenberg-Richter law, one assumes the existence of another power, the law of the fractal distribution. The authors present results of a simple stick slip model of earthquakes, which evolves to a self-organized critical state. Emphasis is on demonstrating that empirical power laws for earthquakes indicate that the Earth's crust is at the critical state, with no typical time, space, or energy scale. Of course, the model is tremendously oversimplified; however in analogy with equilibrium phenomena, they do not expect criticality to depend on details of the model (universality). JF - BNL (Brookhaven National Laboratory) AU - Bak, P AU - Chen, K Y1 - 1995 PY - 1995 DA - 1995 SP - 9 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - mathematical models KW - elastic waves KW - simulation KW - seismic response KW - rock mechanics KW - fractures KW - aftershocks KW - spatial variations KW - physical properties KW - risk assessment KW - seismic waves KW - arrival time KW - fractals KW - earthquakes KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52864599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bak%2C+P%3BChen%2C+K&rft.aulast=Bak&rft.aufirst=P&rft.date=1995-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Fractal+dynamics+of+earthquakes&rft.title=Fractal+dynamics+of+earthquakes&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1996-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE95011783NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - aftershocks; arrival time; earthquakes; elastic waves; fractals; fractures; mathematical models; physical properties; risk assessment; rock mechanics; seismic response; seismic waves; simulation; spatial variations ER - TY - JOUR T1 - Asphaltene adsorption on kaolinite; characterization by infrared microspectroscopy and X-ray absorption spectroscopy AN - 52842909; 1996-039536 AB - An improved knowledge of rock wettability is of primary importance to estimate the amount of crude oil in underground resources. It has been observed that the trapping of oils in sedimentary rocks is largely correlated to the presence of kaolinite clays in the rocks' intergranular space. Fourier transform IR microspectroscopy and X-ray absorption fine structure spectroscopy analysis performed at the Al and Si K-thresholds on kaolinite wetted by asphaltene show that oil modifies the local environment of aluminium in this material and more precisely the Al-OH linkage. JF - Comptes Rendus de l'Academie des Sciences, Serie II. Sciences de la Terre et des Planetes AU - Bantignies, J L AU - Cartier, C AU - Dexpert, H AU - Flank, A M AU - Williams, G Y1 - 1995 PY - 1995 DA - 1995 SP - 699 EP - 706 PB - Gauthier-Villars, Montrouge VL - 320 IS - 8 SN - 1251-8050, 1251-8050 KW - silicates KW - petroleum exploration KW - organic residues KW - stratigraphic traps KW - petroleum KW - crystal structure KW - bonding KW - reservoir rocks KW - evaluation KW - absorption KW - infrared spectroscopy KW - sedimentary rocks KW - atomic packing KW - aluminum KW - X-ray analysis KW - asphalt KW - kaolinite KW - adsorption KW - deformation KW - clay minerals KW - hydroxyl ion KW - bitumens KW - metals KW - X-ray spectroscopy KW - traps KW - wettability KW - sheet silicates KW - economics KW - spectroscopy KW - 29A:Economic geology, geology of energy sources KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52842909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comptes+Rendus+de+l%27Academie+des+Sciences%2C+Serie+II.+Sciences+de+la+Terre+et+des+Planetes&rft.atitle=Asphaltene+adsorption+on+kaolinite%3B+characterization+by+infrared+microspectroscopy+and+X-ray+absorption+spectroscopy&rft.au=Bantignies%2C+J+L%3BCartier%2C+C%3BDexpert%2C+H%3BFlank%2C+A+M%3BWilliams%2C+G&rft.aulast=Bantignies&rft.aufirst=J&rft.date=1995-01-01&rft.volume=320&rft.issue=8&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Comptes+Rendus+de+l%27Academie+des+Sciences%2C+Serie+II.+Sciences+de+la+Terre+et+des+Planetes&rft.issn=12518050&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom | Reference includes data from PASCAL, Institute de l'Information Scientifique et Technique, Vandoeuvre-les-Nancy, France N1 - Date revised - 1996-01-01 N1 - Number of references - 28 N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absorption; adsorption; aluminum; asphalt; atomic packing; bitumens; bonding; clay minerals; crystal structure; deformation; economics; evaluation; hydroxyl ion; infrared spectroscopy; kaolinite; metals; organic residues; petroleum; petroleum exploration; reservoir rocks; sedimentary rocks; sheet silicates; silicates; spectroscopy; stratigraphic traps; traps; wettability; X-ray analysis; X-ray spectroscopy ER - TY - JOUR T1 - Dynamic response of a pair of walls retaining a viscoelastic solid AN - 52795774; 1996-070573 AB - Making use of a previously reported, simple, approximate method of analysis, a critical evaluation is made of the dynamic pressures and forces induced by horizontal ground shaking on a pair of infinitely long, parallel walls retaining a uniform viscoelastic solid. The walls are presumed to be rigid but elastically constrained against rotation at their base. The effects of both harmonic and earthquake-induced excitations are examined. The accuracy of the method is assessed by comparing its predictions for the special case of fixed-based walls with those obtained by an exact method, and comprehensive numerical data are presented which elucidate the underlying response mechanisms, and the effects and relative importance of the parameters involved. The parameters examined include the characteristics of the ground motion, the ratio of the distance between walls to the height of the contained material, and the flexibility of the rotational wall constraints. In addition to valuable insights into the responses of the systems investigated, the results presented provide a convenient framework for the analysis of more complex systems as well. JF - BNL (Brookhaven National Laboratory) AU - Veletsos, A S AU - Parikh, V H AU - Younan, A H AU - Bandyopadhyay, K Y1 - 1995/01// PY - 1995 DA - January 1995 SP - 52 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - soil mechanics KW - numerical models KW - dynamic loading KW - loading KW - elastic properties KW - seismic response KW - harmonics KW - foundations KW - soil-structure interface KW - viscosity KW - ground motion KW - earthquakes KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52795774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Veletsos%2C+A+S%3BParikh%2C+V+H%3BYounan%2C+A+H%3BBandyopadhyay%2C+K&rft.aulast=Veletsos&rft.aufirst=A&rft.date=1995-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Dynamic+response+of+a+pair+of+walls+retaining+a+viscoelastic+solid&rft.title=Dynamic+response+of+a+pair+of+walls+retaining+a+viscoelastic+solid&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1996-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE95012092NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - dynamic loading; earthquakes; elastic properties; foundations; ground motion; harmonics; loading; numerical models; seismic response; soil mechanics; soil-structure interface; viscosity ER - TY - JOUR T1 - Database activities at Brookhaven National Laboratory AN - 52775772; 1997-001819 AB - Brookhaven National Laboratory is a multi-disciplinary lab in the DOE system of research laboratories. Database activities are correspondingly diverse within the restrictions imposed by the dominant relational database paradigm. The authors discuss related activities and tools used in RHIC and in the other major projects at BNL. The others are the Protein Data Bank being maintained by the Chemistry department, and a Geographical Information System (GIS)--a Superfund sponsored environmental monitoring project under development in the Office of Environmental Restoration. JF - BNL (Brookhaven National Laboratory) AU - Trahern, C G Y1 - 1995 PY - 1995 DA - 1995 SP - 4 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - United States KW - organic materials KW - U. S. Department of Energy KW - monitoring KW - Brookhaven National Laboratory KW - Superfund KW - pollutants KW - government agencies KW - data processing KW - pollution KW - remediation KW - ground water KW - Suffolk County New York KW - organic compounds KW - New York KW - geographic information systems KW - planning KW - data bases KW - information systems KW - data retrieval KW - proteins KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52775772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Trahern%2C+C+G&rft.aulast=Trahern&rft.aufirst=C&rft.date=1995-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Database+activities+at+Brookhaven+National+Laboratory&rft.title=Database+activities+at+Brookhaven+National+Laboratory&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1997-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE96003128NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Presented at the IADBC workshop on databases for accelerators Chicago, IL, Nov. 6-8, 1995; Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - Brookhaven National Laboratory; data bases; data processing; data retrieval; geographic information systems; government agencies; ground water; information systems; monitoring; New York; organic compounds; organic materials; planning; pollutants; pollution; proteins; remediation; Suffolk County New York; Superfund; U. S. Department of Energy; United States ER - TY - JOUR T1 - Mass extinctions vs. uniformitarianism in biological evolution AN - 52765591; 1997-016099 AB - It is usually believed that Darwin's theory leads to a smooth gradual evolution, so that mass extinctions must be caused by external shocks. However, it has recently been argued that mass extinctions arise from the intrinsic dynamics of Darwinian evolution. Species become extinct when swept by intermittent avalanches propagating through the global ecology. These ideas are made concrete through studies of simple mathematical models of co-evolving species. The models exhibit self-organized criticality and describe some general features of the extinction pattern in the fossil record. JF - BNL (Brookhaven National Laboratory) AU - Bak, P AU - Paczuski, M Y1 - 1995 PY - 1995 DA - 1995 SP - 17 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - uniformitarianism KW - dynamics KW - mathematical models KW - global change KW - biologic evolution KW - mass extinctions KW - fossils KW - fossil record KW - gradualism KW - paleontology KW - Darwinism KW - 08:General paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52765591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bak%2C+P%3BPaczuski%2C+M&rft.aulast=Bak&rft.aufirst=P&rft.date=1995-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Mass+extinctions+vs.+uniformitarianism+in+biological+evolution&rft.title=Mass+extinctions+vs.+uniformitarianism+in+biological+evolution&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1997-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE96010502NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Presented at Physics of biological systems, Korgerup Hojskole, Denmark, Aug. 14-26, 1995; Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - biologic evolution; Darwinism; dynamics; fossil record; fossils; global change; gradualism; mass extinctions; mathematical models; paleontology; uniformitarianism ER - TY - BOOK T1 - Radionuclide release, ground-water transport and geochemical processes AN - 51374204; 2007-105241 JF - Finite element modeling of environmental problems; surface and subsurface flow and transport AU - MacKinnon, R J AU - Sullivan, T M A2 - Carey, Graham F. Y1 - 1995 PY - 1995 DA - 1995 PB - John Wiley & Sons, Chichester SN - 0471956627 KW - solute transport KW - hazardous waste KW - degradation KW - contaminant plumes KW - data processing KW - aqueous solutions KW - solution KW - radioactive waste KW - ground water KW - chemical reactions KW - transport KW - digital simulation KW - hydrodynamics KW - processes KW - toxic materials KW - diffusion KW - numerical models KW - underground storage KW - pollutants KW - pollution KW - equations KW - two-dimensional models KW - flows KW - mathematical methods KW - underground installations KW - multiphase flow KW - waste disposal KW - leaching KW - storage KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51374204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=MacKinnon%2C+R+J%3BSullivan%2C+T+M&rft.aulast=MacKinnon&rft.aufirst=R&rft.date=1995-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0471956627&rft.btitle=Radionuclide+release%2C+ground-water+transport+and+geochemical+processes&rft.title=Radionuclide+release%2C+ground-water+transport+and+geochemical+processes&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 23 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Waste encapsulation by in situ vitrification AN - 51370449; 2007-105247 JF - Finite element modeling of environmental problems; surface and subsurface flow and transport AU - McLay, R T AU - Carey, Graham F AU - MacKinnon, R J A2 - Carey, Graham F. Y1 - 1995 PY - 1995 DA - 1995 PB - John Wiley & Sons, Chichester SN - 0471956627 KW - hazardous waste KW - numerical models KW - underground storage KW - engineering properties KW - viscous materials KW - thermal properties KW - data processing KW - equations KW - melts KW - flows KW - finite element analysis KW - vitrification KW - mathematical methods KW - digital simulation KW - underground installations KW - velocity KW - heat transfer KW - waste disposal KW - construction KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51370449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=McLay%2C+R+T%3BCarey%2C+Graham+F%3BMacKinnon%2C+R+J&rft.aulast=McLay&rft.aufirst=R&rft.date=1995-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0471956627&rft.btitle=Waste+encapsulation+by+in+situ+vitrification&rft.title=Waste+encapsulation+by+in+situ+vitrification&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 11 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 ER - TY - RPRT T1 - Sorption of radioactive contaminants by sediment from the Kara Sea AN - 50863820; 2008-095892 JF - Arctic Nuclear Waste Assessment Program workshop AU - Fuhrmann, Mark AU - Zhou, Huan AU - Neiheisel, James AU - Dyer, Robert Y1 - 1995 PY - 1995 DA - 1995 KW - sorption KW - isotopes KW - radioactivity KW - pollutants KW - human activity KW - pollution KW - radioactive waste KW - marine sediments KW - radioactive isotopes KW - Kara Sea KW - sediments KW - Arctic Ocean KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50863820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Fuhrmann%2C+Mark%3BZhou%2C+Huan%3BNeiheisel%2C+James%3BDyer%2C+Robert&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=1995-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Sorption+of+radioactive+contaminants+by+sediment+from+the+Kara+Sea&rft.title=Sorption+of+radioactive+contaminants+by+sediment+from+the+Kara+Sea&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Arctic Nuclear Waste Assessment Program workshop N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Availability - Office of Naval Research, United States N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Middle Devonian temperate water bioherms of eastern New York State (Edgecliff Member, Onondaga Formation) AN - 50331411; 1997-032355 JF - Guidebook - New York State Geological Association, Meeting AU - Wolosz, Thomas H AU - Paquette, Douglas E Y1 - 1995 PY - 1995 DA - 1995 SP - 227 EP - 250 PB - New York State Geological Association, New York, NY VL - 67 SN - 1061-8724, 1061-8724 KW - United States KW - limestone KW - Seneca Falls New York KW - shallow-water environment KW - Port Colborne Ontario KW - oxygen KW - Porifera KW - isotopes KW - bioherms KW - field trips KW - biogeography KW - Buffalo New York KW - stable isotopes KW - road log KW - sedimentary rocks KW - Erie County New York KW - carbon KW - Brachiopoda KW - biostromes KW - Stromatoporoidea KW - Anthozoa KW - Oriskany Sandstone KW - Invertebrata KW - Seneca County New York KW - cement KW - sedimentary structures KW - Onondaga Limestone KW - reef environment KW - temperate environment KW - Paleozoic KW - biogenic structures KW - Clarence Member KW - C-13/C-12 KW - O-18/O-16 KW - Coelenterata KW - Ontario KW - luminescence KW - Lower Devonian KW - New York KW - Edgecliff Member KW - Middle Devonian KW - Devonian KW - Canada KW - diagenesis KW - Cnidaria KW - Eastern Canada KW - carbonate rocks KW - 06A:Sedimentary petrology KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50331411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Guidebook+-+New+York+State+Geological+Association%2C+Meeting&rft.atitle=Middle+Devonian+temperate+water+bioherms+of+eastern+New+York+State+%28Edgecliff+Member%2C+Onondaga+Formation%29&rft.au=Wolosz%2C+Thomas+H%3BPaquette%2C+Douglas+E&rft.aulast=Wolosz&rft.aufirst=Thomas&rft.date=1995-01-01&rft.volume=67&rft.issue=&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Guidebook+-+New+York+State+Geological+Association%2C+Meeting&rft.issn=10618724&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Combined meeting of the New York State Geological Association 67th annual meeting and the Eastern Section of the American Association of Petroleum Geologists 26th annual meeting N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 43 N1 - PubXState - NY N1 - Document feature - illus. incl. sects., 2 tables, geol. sketch maps N1 - Last updated - 2017-02-17 N1 - SubjectsTermNotLitGenreText - Anthozoa; biogenic structures; biogeography; bioherms; biostromes; Brachiopoda; Buffalo New York; C-13/C-12; Canada; carbon; carbonate rocks; cement; Clarence Member; Cnidaria; Coelenterata; Devonian; diagenesis; Eastern Canada; Edgecliff Member; Erie County New York; field trips; Invertebrata; isotopes; limestone; Lower Devonian; luminescence; Middle Devonian; New York; O-18/O-16; Onondaga Limestone; Ontario; Oriskany Sandstone; oxygen; Paleozoic; Porifera; Port Colborne Ontario; reef environment; road log; sedimentary rocks; sedimentary structures; Seneca County New York; Seneca Falls New York; shallow-water environment; stable isotopes; Stromatoporoidea; temperate environment; United States ER - TY - BOOK T1 - Fractal dynamics of earthquakes AN - 50105373; 1995-068565 JF - Fractals in the earth sciences AU - Bak, P AU - Chen, K A2 - Barton, Christopher C. A2 - La Pointe, Paul R. Y1 - 1995 PY - 1995 DA - 1995 PB - Plenum Press, New York, NY SN - 0306448653 KW - dynamics KW - one-dimensional models KW - mathematical methods KW - statistical analysis KW - thickness KW - friction KW - equations KW - simulation KW - fractals KW - earthquakes KW - crust KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50105373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bak%2C+P%3BChen%2C+K&rft.aulast=Bak&rft.aufirst=P&rft.date=1995-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0306448653&rft.btitle=Fractal+dynamics+of+earthquakes&rft.title=Fractal+dynamics+of+earthquakes&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - Number of references - 30 N1 - PubXState - NY N1 - Document feature - illus. N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Joint ASME/JSME pressure vessels and piping conference AN - 50063889; 1996-017802 AB - In an effort to evaluate earthquake liquefaction potential of soil media, several statistical models ranging from purely empirical to mathematically sophisticated have been devised. While deterministic methods define susceptibility of a soil structure to liquefaction for a given seismic event, in the sense that the site does or does not liquefy, probabilistic approaches incorporate statistical properties associated with both the earthquake and site characterization. In this study a stochastic model is formulated to assess liquefaction potential of soil structures in general and earth dams in particular induced by earthquakes. Such earthquakes are realizations of a random process expressed in the form of a power spectral density. Uncertainties in the soil resistance to liquefaction are also introduced with probability density functions around in-situ measurements of parameters associated with the soil strength. The attempt of this study is to devise a procedure that will lead to a continuous probability of liquefaction at a given site. Monte Carlo simulations are employed for the probabilistic model. In addition a stochastic model is presented. The dynamic response of the two-phase medium is obtained with the help of the POROSLAM code and it is expressed in the form of a transfer function. JF - BNL (Brookhaven National Laboratory) AU - Simos, N AU - Costantino, C J AU - Reich, M Y1 - 1995 PY - 1995 DA - 1995 SP - 8 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - soil mechanics KW - geologic hazards KW - Monte Carlo analysis KW - stress KW - statistical analysis KW - mathematical models KW - land subsidence KW - liquefaction potential KW - liquefaction KW - soil-structure interface KW - stochastic processes KW - seismic risk KW - dams KW - ground motion KW - risk assessment KW - probability KW - earthquakes KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50063889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BNL+%28Brookhaven+National+Laboratory%29&rft.atitle=Joint+ASME%2FJSME+pressure+vessels+and+piping+conference&rft.au=Simos%2C+N%3BCostantino%2C+C+J%3BReich%2C+M&rft.aulast=Simos&rft.aufirst=N&rft.date=1995-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BNL+%28Brookhaven+National+Laboratory%29&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Joint ASME/JSME pressure vessels and piping conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1996-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE95008867NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - dams; earthquakes; geologic hazards; ground motion; land subsidence; liquefaction; liquefaction potential; mathematical models; Monte Carlo analysis; probability; risk assessment; seismic risk; soil mechanics; soil-structure interface; statistical analysis; stochastic processes; stress ER - TY - JOUR T1 - Permeable, subsurface and sorbent barrier for Sr-90: laboratory studies of natural and synthetic materials AN - 13638866; 199605558 AB - A range of materials (natural zeolites and metal oxides) were investigated for use in the construction of a full-scale, in-situ sorbent barrier for intercepting a strontium-90 plume within a surficial water-bearing sand and gravel layer. Initially, a series of bath sorption tests using a strontium-85 tracer were carried out, followed by further testing on selected materials in flow-through columns to assess their performance. The results suggest that fine-grained clinoptilolite can attenuate strontium-90 for longer periods of time than was the case with the other materials that were investigated. From the model simulations, a minimal barrier thickness of 1.2 m was recommended for the full-scale design. There is evidence to indicate that the maximal life expectancy of the material would be 10 years prior to removal and possible regeneration. JF - Waste Management AU - Fuhrmann, M AU - Aloysius, D AU - Zhou, H AD - Brookhaven National Laboratory, Upton, N. Y. Y1 - 1995 PY - 1995 DA - 1995 SP - 485 EP - 493 VL - 15 IS - 7 SN - 0956-053X, 0956-053X KW - Columns KW - Modelling (-general-) KW - Aqualine Abstracts KW - AQ 00001:Water Resources and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13638866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Waste+Management&rft.atitle=Permeable%2C+subsurface+and+sorbent+barrier+for+Sr-90%3A+laboratory+studies+of+natural+and+synthetic+materials&rft.au=Fuhrmann%2C+M%3BAloysius%2C+D%3BZhou%2C+H&rft.aulast=Fuhrmann&rft.aufirst=M&rft.date=1995-01-01&rft.volume=15&rft.issue=7&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Waste+Management&rft.issn=0956053X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Formation and diagenesis of macromolecular organic sulfur in Peru margin sediments AN - 50160008; 1995-031106 JF - Organic Geochemistry AU - Eglinton, Timothy I AU - Irvine, Joyce E AU - Vairavamurthy, Appathurai AU - Zhou, Weiqing AU - Manowitz, Bernard A2 - Telnaes, Nils A2 - van Graas, Ger A2 - Oygard, Kjell Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 781 EP - 799 PB - Pergamon, Oxford-New York VL - 22 IS - 3-5 SN - 0146-6380, 0146-6380 KW - United States KW - fatty acids KW - lipids KW - toluene KW - gas chromatograms KW - mass spectra KW - nitrogen KW - Cenozoic KW - California KW - Monterey Formation KW - marine sediments KW - pyrolysis KW - isoprenoids KW - carbon KW - thermal maturity KW - sediments KW - Peru KW - spectra KW - organic carbon KW - organic sulfur KW - organic materials KW - modern analogs KW - methylthiophene KW - Miocene KW - genesis KW - bitumens KW - Tertiary KW - South America KW - sample preparation KW - organic compounds KW - organic acids KW - X-ray data KW - Neogene KW - diagenesis KW - chromatograms KW - hydrocarbons KW - sulfur KW - South Atlantic KW - kerogen KW - Atlantic Ocean KW - aromatic hydrocarbons KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50160008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+Geochemistry&rft.atitle=Formation+and+diagenesis+of+macromolecular+organic+sulfur+in+Peru+margin+sediments&rft.au=Eglinton%2C+Timothy+I%3BIrvine%2C+Joyce+E%3BVairavamurthy%2C+Appathurai%3BZhou%2C+Weiqing%3BManowitz%2C+Bernard&rft.aulast=Eglinton&rft.aufirst=Timothy&rft.date=1994-12-01&rft.volume=22&rft.issue=3-5&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Organic+Geochemistry&rft.issn=01466380&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/01466380 LA - English DB - GeoRef N1 - Conference title - Advances in organic geochemistry; 16th international meeting on Organic geochemistry N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - Number of references - 62 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aromatic hydrocarbons; Atlantic Ocean; bitumens; California; carbon; Cenozoic; chromatograms; diagenesis; fatty acids; gas chromatograms; genesis; hydrocarbons; isoprenoids; kerogen; lipids; marine sediments; mass spectra; methylthiophene; Miocene; modern analogs; Monterey Formation; Neogene; nitrogen; organic acids; organic carbon; organic compounds; organic materials; organic sulfur; Peru; pyrolysis; sample preparation; sediments; South America; South Atlantic; spectra; sulfur; Tertiary; thermal maturity; toluene; United States; X-ray data ER - TY - JOUR T1 - Mechanism of SeO (super 2-) (sub 4) substitution in calcite; an XAFS study AN - 50152293; 1995-036725 AB - The position of the Se K-edge is consistent with oxidation state 6+ and the first shell contains four O atoms at a distance of 1.63 Aa; Se is thus present as the tetrahedral SeO (super 2-) (sub 4 ) complex ion. The second shell is split and best fitted by two Ca atoms at 3.17 Aa and four Ca atoms at 3.49 Aa. The coordination indicated by the second shell is consistent with substitution of the SeO (super 2-) (sub 4 ) ion in the CO (sub 3) site of calcite which has six nearest-neighbour Ca atoms. Significant distortion of the site is consistent with the Se-Ca distances. Two models for the local coordination of the SeO (super 2-) (sub 4 ) ion are discussed. JF - Geochimica et Cosmochimica Acta AU - Reeder, Richard J AU - Lamble, Geraldine M AU - Lee, Jyh-Fu AU - Staudt, Wilfried J Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 5639 EP - 5646 PB - Pergamon, Oxford VL - 58 IS - 24 SN - 0016-7037, 0016-7037 KW - partitioning KW - X-ray data KW - substitution KW - aqueous solutions KW - carbonates KW - SeO2-4 KW - calcite KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50152293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Mechanism+of+SeO+%28super+2-%29+%28sub+4%29+substitution+in+calcite%3B+an+XAFS+study&rft.au=Reeder%2C+Richard+J%3BLamble%2C+Geraldine+M%3BLee%2C+Jyh-Fu%3BStaudt%2C+Wilfried+J&rft.aulast=Reeder&rft.aufirst=Richard&rft.date=1994-12-01&rft.volume=58&rft.issue=24&rft.spage=5639&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2F0016-7037%2894%2990256-9 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1995-01-01 N1 - Number of references - 26 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - aqueous solutions; calcite; carbonates; partitioning; SeO2-4; substitution; X-ray data DO - http://dx.doi.org/10.1016/0016-7037(94)90256-9 ER - TY - JOUR T1 - High-accuracy measurements of total dissolved inorganic carbon in the ocean; comparison of alternate detection methods; discussion AN - 1629945249; 2014-094848 JF - Marine Chemistry AU - Wills, K AU - Johnson, K M Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 87 EP - 88 PB - Elsevier, Amsterdam VL - 48 IS - 1 SN - 0304-4203, 0304-4203 KW - methods KW - high-resolution methods KW - concentration KW - experimental studies KW - chemical analysis KW - sea water KW - solution KW - measurement KW - inorganic materials KW - carbon dioxide KW - carbon KW - colorimetry KW - accuracy KW - instruments KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629945249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Chemistry&rft.atitle=High-accuracy+measurements+of+total+dissolved+inorganic+carbon+in+the+ocean%3B+comparison+of+alternate+detection+methods%3B+discussion&rft.au=Wills%2C+K%3BJohnson%2C+K+M&rft.aulast=Wills&rft.aufirst=K&rft.date=1994-12-01&rft.volume=48&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Marine+Chemistry&rft.issn=03044203&rft_id=info:doi/10.1016%2F0304-4203%2894%2990065-5 L2 - http://www.sciencedirect.com/science/journal/03044203 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2014-01-01 N1 - Number of references - 1 N1 - Document feature - 1 table N1 - SuppNotes - For reference to original see Goyet, C. and Snover, A. K., Mar. Chem., Vol. 44, p. 235-242, 1993 N1 - Last updated - 2014-12-04 N1 - CODEN - MRCHBD N1 - SubjectsTermNotLitGenreText - accuracy; carbon; carbon dioxide; chemical analysis; colorimetry; concentration; experimental studies; high-resolution methods; inorganic materials; instruments; measurement; methods; sea water; solution DO - http://dx.doi.org/10.1016/0304-4203(94)90065-5 ER - TY - JOUR T1 - Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase. AN - 76790072; 7947684 AB - The eukaryotic fatty acid desaturases are iron-containing enzymes that catalyze the NAD-(P)H- and O2-dependent introduction of double bonds into methylene-interrupted fatty acyl chains. Examination of deduced amino acid sequences for the membrane desaturases from mammals, fungi, insects, higher plants, and cyanobacteria has revealed three regions of conserved primary sequence containing HX(3 or 4)H,HX(2 or 3)HH, and HX(2 or 3)HH. This motif is also present in the bacterial membrane enzymes alkane hydroxylase (omega-hydroxylase) and xylene monooxygenase. Hydropathy analyses indicate that these enzymes contain up to three long hydrophobic domains which would be long enough to span the membrane bilayer twice. The conserved His-containing regions have a consistent positioning with respect to these potential membrane spanning domains. Taken together, these observations suggest that the membrane fatty acid desaturases and hydrocarbon hydroxylases have a related protein fold, possibly arising from a common ancestral origin. In order to examine the functional role of these conserved His residues, we have made use of the ability of the rat delta 9 desaturase gene to complement a yeast strain deficient in the delta 9 desaturase gene function (ole1). By site-directed mutagenesis, eight conserved His residues in the rat delta 9 desaturase were individually converted to Ala. Each His-->Ala mutation failed to complement the yeast ole1 mutant. In contrast, mutation of three nonconserved flanking His residues or a partially conserved Arg residue within the conserved motif to Ala allowed for complementation of the ole1 phenotype.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Biochemistry AU - Shanklin, J AU - Whittle, E AU - Fox, B G AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1994/11/01/ PY - 1994 DA - 1994 Nov 01 SP - 12787 EP - 12794 VL - 33 IS - 43 SN - 0006-2960, 0006-2960 KW - Histidine KW - 4QD397987E KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Mixed Function Oxygenases KW - EC 1.- KW - Oxygenases KW - EC 1.13.- KW - xylene monooxygenase KW - EC 1.14.13.- KW - Cytochrome P-450 CYP4A KW - EC 1.14.15.3 KW - Stearoyl-CoA Desaturase KW - EC 1.14.19.1 KW - Index Medicus KW - Phylogeny KW - Animals KW - Liver -- enzymology KW - Amino Acid Sequence KW - Saccharomyces cerevisiae -- enzymology KW - Saccharomyces cerevisiae -- genetics KW - Mutagenesis, Site-Directed KW - Rats KW - Base Sequence KW - Pseudomonas -- enzymology KW - Genetic Complementation Test KW - Molecular Sequence Data KW - Catalysis KW - Stearoyl-CoA Desaturase -- metabolism KW - Mixed Function Oxygenases -- chemistry KW - Conserved Sequence KW - Stearoyl-CoA Desaturase -- genetics KW - Cytochrome P-450 Enzyme System -- chemistry KW - Stearoyl-CoA Desaturase -- chemistry KW - Oxygenases -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76790072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Eight+histidine+residues+are+catalytically+essential+in+a+membrane-associated+iron+enzyme%2C+stearoyl-CoA+desaturase%2C+and+are+conserved+in+alkane+hydroxylase+and+xylene+monooxygenase.&rft.au=Shanklin%2C+J%3BWhittle%2C+E%3BFox%2C+B+G&rft.aulast=Shanklin&rft.aufirst=J&rft.date=1994-11-01&rft.volume=33&rft.issue=43&rft.spage=12787&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-12-01 N1 - Date created - 1994-12-01 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Continental margins; sources or sinks of anthropogenic CO2? AN - 52758714; 1997-014070 JF - Eos, Transactions, American Geophysical Union AU - Falkowski, P AU - Anonymous Y1 - 1994/11// PY - 1994 DA - November 1994 SP - 311 PB - American Geophysical Union, Washington, DC VL - 75 IS - 44, Suppl. SN - 0096-3941, 0096-3941 KW - continental margin KW - human activity KW - atmosphere KW - air-sea interface KW - geochemical cycle KW - carbon dioxide KW - nutrients KW - marine environment KW - carbon KW - shelf environment KW - continental shelf KW - geochemistry KW - 07:Oceanography KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52758714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Continental+margins%3B+sources+or+sinks+of+anthropogenic+CO2%3F&rft.au=Falkowski%2C+P%3BAnonymous&rft.aulast=Falkowski&rft.aufirst=P&rft.date=1994-11-01&rft.volume=75&rft.issue=44%2C+Suppl.&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1994 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - air-sea interface; atmosphere; carbon; carbon dioxide; continental margin; continental shelf; geochemical cycle; geochemistry; human activity; marine environment; nutrients; shelf environment ER - TY - JOUR T1 - Physical transport processes affecting the transport and fate of carbon in the southern Mid-Atlantic Bight AN - 52757760; 1997-014146 JF - Eos, Transactions, American Geophysical Union AU - Pietrafesa, L J AU - Churchill, J H AU - Williams, A J AU - Wirick, C D AU - Anonymous Y1 - 1994/11// PY - 1994 DA - November 1994 SP - 324 PB - American Geophysical Union, Washington, DC VL - 75 IS - 44, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - Northwest Atlantic KW - ocean circulation KW - Cape Hatteras KW - sedimentation KW - Dare County North Carolina KW - SEEP II Program KW - marine transport KW - geochemical cycle KW - marine sediments KW - continental margin sedimentation KW - carbon KW - North Carolina KW - sediments KW - storms KW - North Atlantic KW - Middle Atlantic Bight KW - geochemistry KW - Atlantic Ocean KW - boundary layer KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52757760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Physical+transport+processes+affecting+the+transport+and+fate+of+carbon+in+the+southern+Mid-Atlantic+Bight&rft.au=Pietrafesa%2C+L+J%3BChurchill%2C+J+H%3BWilliams%2C+A+J%3BWirick%2C+C+D%3BAnonymous&rft.aulast=Pietrafesa&rft.aufirst=L&rft.date=1994-11-01&rft.volume=75&rft.issue=44%2C+Suppl.&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1994 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; boundary layer; Cape Hatteras; carbon; continental margin sedimentation; Dare County North Carolina; geochemical cycle; geochemistry; marine sediments; marine transport; Middle Atlantic Bight; North Atlantic; North Carolina; Northwest Atlantic; ocean circulation; sedimentation; sediments; SEEP II Program; storms; United States ER - TY - JOUR T1 - Sulfonates; a novel class of organic sulfur compounds in marine sediments AN - 50192844; 1995-009529 AB - Sulphur speciation was studied on sediments from organic-rich areas: the Peru margin, a salt-marsh, Shelter Island, New York, and the coastal intertidal zones of Great South Bay, New York. X-ray absorption near-edge structure spectroscopy established sulphonates as a novel and major component in the organic S in these samples. Biological and geochemical mechanisms are possible for their occurrence, and the biogeochemical implications of the presence of sulphonates in marine sediments are discussed. JF - Geochimica et Cosmochimica Acta AU - Vairavamurthy, Appathurai AU - Zhou, Weiqing AU - Eginton, Timothy AU - Manowitz, Bernard Y1 - 1994/11// PY - 1994 DA - November 1994 SP - 4681 EP - 4687 PB - Pergamon, Oxford VL - 58 IS - 21 SN - 0016-7037, 0016-7037 KW - organic materials KW - sulfonates KW - biochemistry KW - sedimentation KW - mechanism KW - marine sedimentation KW - geochemical cycle KW - organic compounds KW - marine sediments KW - sediments KW - sulfur KW - reduction KW - organic sulfur KW - Eh KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50192844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Sulfonates%3B+a+novel+class+of+organic+sulfur+compounds+in+marine+sediments&rft.au=Vairavamurthy%2C+Appathurai%3BZhou%2C+Weiqing%3BEginton%2C+Timothy%3BManowitz%2C+Bernard&rft.aulast=Vairavamurthy&rft.aufirst=Appathurai&rft.date=1994-11-01&rft.volume=58&rft.issue=21&rft.spage=4681&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2F0016-7037%2894%2990200-3 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1995-01-01 N1 - Number of references - 40 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - biochemistry; chemical fractionation; Eh; geochemical cycle; marine sedimentation; marine sediments; mechanism; organic compounds; organic materials; organic sulfur; reduction; sedimentation; sediments; sulfonates; sulfur DO - http://dx.doi.org/10.1016/0016-7037(94)90200-3 ER - TY - JOUR T1 - New laboratory determinations of thermal diffusivity AN - 50148561; 1995-033794 JF - Eos, Transactions, American Geophysical Union AU - Mu, Chai AU - Abramson, E AU - Brown, J M AU - Slutsky, L J AU - Anonymous Y1 - 1994/11// PY - 1994 DA - November 1994 SP - 633 PB - American Geophysical Union, Washington, DC VL - 75 IS - 44, Suppl. SN - 0096-3941, 0096-3941 KW - silicates KW - upper mantle KW - experimental studies KW - pyroxene group KW - thermal diffusivity KW - composition KW - mantle KW - orthopyroxene KW - anisotropy KW - geophysics KW - chain silicates KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50148561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=New+laboratory+determinations+of+thermal+diffusivity&rft.au=Mu%2C+Chai%3BAbramson%2C+E%3BBrown%2C+J+M%3BSlutsky%2C+L+J%3BAnonymous&rft.aulast=Mu&rft.aufirst=Chai&rft.date=1994-11-01&rft.volume=75&rft.issue=44%2C+Suppl.&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1994 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - anisotropy; chain silicates; composition; experimental studies; geophysics; mantle; orthopyroxene; pyroxene group; silicates; thermal diffusivity; upper mantle ER - TY - JOUR T1 - Slow recovery of human brain MAO B after L-deprenyl (Selegeline) withdrawal. AN - 77714585; 7839316 AB - L-Deprenyl (Selegeline) is an enzyme-activated irreversible inhibitor of monoamine oxidase B (MAO B; EC 1.4.3.4). It is used to treat Parkinson's disease at a dose of 5 mg twice a day. Since enzyme inhibition is irreversible, the recovery of functional enzyme activity after withdrawal from L-deprenyl requires the synthesis of new enzyme. We have measured a 40 day half-time for brain MAO B synthesis in Parkinson's disease and in normal subjects after withdrawal from L-deprenyl. This is the first measurement of the synthesis rate of a specific protein in the living human brain. L-Deprenyl is currently used by 50,000 patients with Parkinson's disease in the United States and its use is expected to increase with reports that it may be beneficial in Alzheimer's disease. The slow turnover of brain MAO B suggests that the current clinical dose of L-deprenyl may be excessive and that the clinical efficacy of reduced dosing should be evaluated. Such an evaluation may have mechanistic importance as well as an impact on reducing the side effects and the costs arising from excessive drug use. JF - Synapse (New York, N.Y.) AU - Fowler, J S AU - Volkow, N D AU - Logan, J AU - Wang, G J AU - MacGregor, R R AU - Schyler, D AU - Wolf, A P AU - Pappas, N AU - Alexoff, D AU - Shea, C AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 86 EP - 93 VL - 18 IS - 2 SN - 0887-4476, 0887-4476 KW - Selegiline KW - 2K1V7GP655 KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Index Medicus KW - Kinetics KW - Humans KW - Tomography, Emission-Computed KW - Aged KW - Middle Aged KW - Models, Biological KW - Parkinson Disease -- drug therapy KW - Male KW - Female KW - Brain -- enzymology KW - Substance Withdrawal Syndrome -- enzymology KW - Selegiline -- adverse effects KW - Selegiline -- therapeutic use KW - Brain -- drug effects KW - Monoamine Oxidase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77714585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Slow+recovery+of+human+brain+MAO+B+after+L-deprenyl+%28Selegeline%29+withdrawal.&rft.au=Fowler%2C+J+S%3BVolkow%2C+N+D%3BLogan%2C+J%3BWang%2C+G+J%3BMacGregor%2C+R+R%3BSchyler%2C+D%3BWolf%2C+A+P%3BPappas%2C+N%3BAlexoff%2C+D%3BShea%2C+C&rft.aulast=Fowler&rft.aufirst=J&rft.date=1994-10-01&rft.volume=18&rft.issue=2&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-01 N1 - Date created - 1995-03-01 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The effects of dose and radiation quality on the shape and power saturation of the EPR signal in alanine. AN - 76770882; 7938443 AB - Variations in the shape and the power saturation of EPR spectra of L-alanine irradiated with photons, electrons, neutrons and protons are reported. It is shown that the ratio of the intensities of the satellite lines attributable to "spin flips" and the central line depend on the EPR microwave power, and it is proposed as a quantitative measure of the signal saturation effect. Dependence of this ratio on the microwave power is affected by the radiation quality and for doses in excess of 10 kGy by the absorbed dose. At high doses of low-LET radiation these changes are attributed to a high local density of free radicals, while for low doses of high-LET radiation these are due to changes induced in the crystal lattice. Consequently, the conventional peak-to-peak amplitude measurement of the EPR signal intensity is inaccurate when used for high doses and for comparison between radiations with different beam quality. The possibility to determine radiation quality from an EPR measurement is discussed. JF - Radiation research AU - Ciesielski, B AU - Wielopolski, L AD - Radiation Therapy Facility, SUNY at Stony Brook, Brookhaven National Laboratory, Upton 11973. Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 105 EP - 111 VL - 140 IS - 1 SN - 0033-7587, 0033-7587 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Space life sciences KW - Dose-Response Relationship, Radiation KW - Linear Energy Transfer KW - Electron Spin Resonance Spectroscopy KW - Alanine -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76770882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=The+effects+of+dose+and+radiation+quality+on+the+shape+and+power+saturation+of+the+EPR+signal+in+alanine.&rft.au=Ciesielski%2C+B%3BWielopolski%2C+L&rft.aulast=Ciesielski&rft.aufirst=B&rft.date=1994-10-01&rft.volume=140&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-11-10 N1 - Date created - 1994-11-10 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: Radiat Res. 1995 Jul;143(1):113-5 [7597138] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The LeRoy Bioherm revisited; evidence of a complex developmental history AN - 52820977; 1996-056838 JF - Guidebook - New York State Geological Association, Meeting AU - Wolosz, Thomas H AU - Paquette, Douglas E A2 - Brett, Carlton E. A2 - Scatterday, James Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 443 EP - 455 PB - New York State Geological Association, New York, NY VL - 66 SN - 1061-8724, 1061-8724 KW - United States KW - guidebook KW - bioherms KW - field trips KW - road log KW - transgression KW - Zoantharia KW - Anthozoa KW - Invertebrata KW - Cladopora KW - sedimentary structures KW - Onondaga Limestone KW - LeRoy Bioherm KW - reef environment KW - Paleozoic KW - biogenic structures KW - quarries KW - Coelenterata KW - genesis KW - sea-level changes KW - New York KW - Middle Devonian KW - Devonian KW - Genesee County New York KW - Cnidaria KW - Tabulata KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52820977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Guidebook+-+New+York+State+Geological+Association%2C+Meeting&rft.atitle=The+LeRoy+Bioherm+revisited%3B+evidence+of+a+complex+developmental+history&rft.au=Wolosz%2C+Thomas+H%3BPaquette%2C+Douglas+E&rft.aulast=Wolosz&rft.aufirst=Thomas&rft.date=1994-10-01&rft.volume=66&rft.issue=&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Guidebook+-+New+York+State+Geological+Association%2C+Meeting&rft.issn=10618724&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 17 N1 - PubXState - NY N1 - Document feature - illus. incl. sects., geol. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Anthozoa; biogenic structures; bioherms; Cladopora; Cnidaria; Coelenterata; Devonian; field trips; Genesee County New York; genesis; guidebook; Invertebrata; LeRoy Bioherm; Middle Devonian; New York; Onondaga Limestone; Paleozoic; quarries; reef environment; road log; sea-level changes; sedimentary structures; Tabulata; transgression; United States; Zoantharia ER - TY - RPRT T1 - In-situ containment and stabilization of buried waste; annual report FY 1994 AN - 52779653; 1997-001483 AB - The two landfills of specific interest are the Chemical Waste Landfill (CWL) and the Mixed Waste Landfill (MWL), both located at Sandia National Laboratory. The work is comprised of two subtasks: (1) In-Situ Barriers and (2) In-Situ Stabilization of Contaminated Soils. The main environmental concern at the CWL is a chromium plume resulting from disposal of chromic acid and chromic sulfuric acid into unlined pits. This program has investigated means of in-situ stabilization of chromium contaminated soils and placement of containment barriers around the CWL. The MWL contains a plume of tritiated water. In-situ immobilization of tritiated water with cementitious grouts was not considered to be a method with a high probability of success and was not pursued. This is discussed further in Section 5.0. Containment barriers for the tritium plume were investigated. FY 94 work focused on stabilization of chromium contaminated soil with blast furnace slag modified grouts to bypass the stage of pre-reduction of Cr(6), barriers for tritiated water containment at the MWL, continued study of barriers for the CWL, and jet grouting field trials for CWL barriers at an uncontaminated site at SNL. Cores from the FY 93 permeation grouting field trails were also tested in FY 94. JF - In-situ containment and stabilization of buried waste; annual report FY 1994 AU - Allan, M L AU - Kukacka, L E Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 70 VL - BNL-60977 KW - United States KW - slag KW - isotopes KW - Bernalillo County New Mexico KW - landfills KW - data KW - grouting KW - tritium KW - New Mexico KW - central New Mexico KW - remediation KW - radioactive waste KW - progress report KW - radioactive isotopes KW - report KW - chemical composition KW - disposal barriers KW - chromium KW - sanitary landfills KW - soils KW - Sandia National Laboratories KW - pollution KW - mechanical properties KW - Albuquerque New Mexico KW - metals KW - hydrogen KW - waste disposal KW - underground disposal KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52779653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Allan%2C+M+L%3BKukacka%2C+L+E&rft.aulast=Allan&rft.aufirst=M&rft.date=1994-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=In-situ+containment+and+stabilization+of+buried+waste%3B+annual+report+FY+1994&rft.title=In-situ+containment+and+stabilization+of+buried+waste%3B+annual+report+FY+1994&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1997-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE95003953NEG, Springfield, VA, United States N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Sulfonates; ubiquitous occurrence of a novel class of organic sulfur compounds in marine sediments AN - 1812214676; 2016-071010 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Vairavamurthy, A AU - Zhou, W AU - Eglinton, T I AU - Manowitz, B AU - Oteyza, Julian Y1 - 1994/08// PY - 1994 DA - August 1994 SP - GEOC EP - 35 PB - American Chemical Society, Washington, DC VL - 208 IS - 1-2 SN - 0065-7727, 0065-7727 KW - concentration KW - sulfonates KW - complexes KW - organic compounds KW - marine sediments KW - chemical reactions KW - sediments KW - sulfur KW - spectra KW - chemical composition KW - new minerals KW - microorganisms KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812214676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Sulfonates%3B+ubiquitous+occurrence+of+a+novel+class+of+organic+sulfur+compounds+in+marine+sediments&rft.au=Vairavamurthy%2C+A%3BZhou%2C+W%3BEglinton%2C+T+I%3BManowitz%2C+B%3BOteyza%2C+Julian&rft.aulast=Vairavamurthy&rft.aufirst=A&rft.date=1994-08-01&rft.volume=208&rft.issue=1-2&rft.spage=GEOC&rft.isbn=0841228388&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th Amrican Chemical Society national meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-08-18 N1 - SubjectsTermNotLitGenreText - chemical composition; chemical fractionation; chemical reactions; complexes; concentration; marine sediments; microorganisms; new minerals; organic compounds; sediments; spectra; sulfonates; sulfur ER - TY - JOUR T1 - Evaluation of abiotic sulfur incorporation as an organic carbon preservation mechanism in Peru margin sediments AN - 1812214463; 2016-070999 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Eglinton, T I AU - Vairavamurthy, A AU - Oteyza, Julian Y1 - 1994/08// PY - 1994 DA - August 1994 SP - GEOC EP - 24 PB - American Chemical Society, Washington, DC VL - 208 IS - 1-2 SN - 0065-7727, 0065-7727 KW - concentration KW - continental margin KW - degradation KW - oxidation KW - evaluation KW - South America KW - organic compounds KW - marine sediments KW - chemical reactions KW - carbon KW - Pacific Ocean KW - sediments KW - sulfur KW - Peru KW - organic carbon KW - preservation KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812214463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Evaluation+of+abiotic+sulfur+incorporation+as+an+organic+carbon+preservation+mechanism+in+Peru+margin+sediments&rft.au=Eglinton%2C+T+I%3BVairavamurthy%2C+A%3BOteyza%2C+Julian&rft.aulast=Eglinton&rft.aufirst=T&rft.date=1994-08-01&rft.volume=208&rft.issue=1-2&rft.spage=GEOC&rft.isbn=0841228388&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th Amrican Chemical Society national meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-08-18 N1 - SubjectsTermNotLitGenreText - carbon; chemical fractionation; chemical reactions; concentration; continental margin; degradation; evaluation; marine sediments; organic carbon; organic compounds; oxidation; Pacific Ocean; Peru; preservation; sediments; South America; sulfur ER - TY - JOUR T1 - Di- and polysulfide cross linking in the formation of humic polymers in marine sediments AN - 1812211780; 2016-071032 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Vairavamurthy, A AU - Zhou, W AU - Manowitz, B AU - Oteyza, Julian Y1 - 1994/08// PY - 1994 DA - August 1994 SP - GEOC EP - 58 PB - American Chemical Society, Washington, DC VL - 208 IS - 1-2 SN - 0065-7727, 0065-7727 KW - degradation KW - biochemistry KW - humic acids KW - measurement KW - organic compounds KW - organic acids KW - marine sediments KW - humic substances KW - chemical reactions KW - bacteria KW - sediments KW - sulfur KW - anaerobic environment KW - reduction KW - sulfides KW - polymers KW - 02C:Geochemistry of rocks, soils, and sediments KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812211780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Di-+and+polysulfide+cross+linking+in+the+formation+of+humic+polymers+in+marine+sediments&rft.au=Vairavamurthy%2C+A%3BZhou%2C+W%3BManowitz%2C+B%3BOteyza%2C+Julian&rft.aulast=Vairavamurthy&rft.aufirst=A&rft.date=1994-08-01&rft.volume=208&rft.issue=1-2&rft.spage=GEOC&rft.isbn=0841228388&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th Amrican Chemical Society national meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-08-18 N1 - SubjectsTermNotLitGenreText - anaerobic environment; bacteria; biochemistry; chemical reactions; degradation; humic acids; humic substances; marine sediments; measurement; organic acids; organic compounds; polymers; reduction; sediments; sulfides; sulfur ER - TY - JOUR T1 - Transformations in organic sulfur speciation during maturation of Monterey Shale; constraints from laboratory experiments AN - 1812211700; 2016-071036 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Nelson, B AU - Eglinton, T I AU - Seewald, J S AU - Vairavamurthy, A AU - Oteyza, Julian Y1 - 1994/08// PY - 1994 DA - August 1994 SP - GEOC EP - 62 PB - American Chemical Society, Washington, DC VL - 208 IS - 1-2 SN - 0065-7727, 0065-7727 KW - United States KW - maturity KW - vitrinite KW - temperature KW - California KW - Monterey Formation KW - sedimentary rocks KW - pyrolysis KW - time factor KW - carbon KW - macerals KW - organic carbon KW - kinetics KW - organic sulfur KW - concentration KW - experimental studies KW - pressure KW - shale KW - organic compounds KW - sulfur KW - kerogen KW - reflectance KW - clastic rocks KW - chemical fractionation KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812211700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Transformations+in+organic+sulfur+speciation+during+maturation+of+Monterey+Shale%3B+constraints+from+laboratory+experiments&rft.au=Nelson%2C+B%3BEglinton%2C+T+I%3BSeewald%2C+J+S%3BVairavamurthy%2C+A%3BOteyza%2C+Julian&rft.aulast=Nelson&rft.aufirst=B&rft.date=1994-08-01&rft.volume=208&rft.issue=1-2&rft.spage=GEOC&rft.isbn=0841228388&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th Amrican Chemical Society national meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-08-18 N1 - SubjectsTermNotLitGenreText - California; carbon; chemical fractionation; clastic rocks; concentration; experimental studies; kerogen; kinetics; macerals; maturity; Monterey Formation; organic carbon; organic compounds; organic sulfur; pressure; pyrolysis; reflectance; sedimentary rocks; shale; sulfur; temperature; time factor; United States; vitrinite ER - TY - JOUR T1 - Application of XANES self-absorption correction to the analysis of sulfur forms in geological samples AN - 1812211456; 2016-071011 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Waldo, G S AU - Penner-Hahn, J E AU - Vairavamurthy, V AU - Manowitz, B AU - Oteyza, Julian Y1 - 1994/08// PY - 1994 DA - August 1994 SP - GEOC EP - 36 PB - American Chemical Society, Washington, DC VL - 208 IS - 1-2 SN - 0065-7727, 0065-7727 KW - methods KW - source rocks KW - X-ray spectra KW - inorganic materials KW - XANES spectra KW - organic compounds KW - errors KW - sulfur KW - spectra KW - corrections KW - chemical composition KW - rocks KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812211456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Application+of+XANES+self-absorption+correction+to+the+analysis+of+sulfur+forms+in+geological+samples&rft.au=Waldo%2C+G+S%3BPenner-Hahn%2C+J+E%3BVairavamurthy%2C+V%3BManowitz%2C+B%3BOteyza%2C+Julian&rft.aulast=Waldo&rft.aufirst=G&rft.date=1994-08-01&rft.volume=208&rft.issue=1-2&rft.spage=GEOC&rft.isbn=0841228388&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th Amrican Chemical Society national meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-08-18 N1 - SubjectsTermNotLitGenreText - chemical composition; corrections; errors; inorganic materials; methods; organic compounds; rocks; source rocks; spectra; sulfur; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Citrate biodegradation; mid-year status report, (January 1994-June 1994) AN - 52652421; 1998-002746 AB - The Uranium Soils Integrated Demonstration (USID) Program was established to demonstrate advanced technologies for the remediation of uranium contaminated soils. This program, managed by the Fernald Environmental Restoration Management Corporation (FERMCO), focuses on the development and demonstration of new soil remediation processes which are faster, safer, and more economical for use at the Fernald site and throughout the DOE complex for cleanup of similar contaminants. Brookhaven National Laboratory (BNL) has developed a process which uses citric acid to treat contaminated soils and wastes with the subsequent recovery of toxic metals and uranium. Citric acid, a naturally occurring organic chelating agent, forms multidentate stable complexes with the transition metals and actinides, and has been effectively used to extract uranium and other metals from solid wastes via the formation of soluble metal citrate complexes. Further studies have also shown that several of the metal citrate complexes are readily biodegraded by microorganisms. During this process, the metals form a precipitate or become associated with the biomass and are recovered at the end of the biodegradation. Although uranyl citrate is recalcitrant to biodegradation, upon exposure to visible light it undergoes photochemical degradation resulting in the formation of an insoluble, stable polymeric form of uranium. JF - BNL (Brookhaven National Laboratory) AU - Francis, A J AU - Dodge, C J AU - Chatterjee, S AU - Landry, M F Y1 - 1994/07// PY - 1994 DA - July 1994 SP - 19 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - soils KW - biodegradation KW - toxic materials KW - pollutants KW - soil treatment KW - pollution KW - remediation KW - progress report KW - metals KW - report KW - uranium KW - waste disposal KW - solid waste KW - actinides KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52652421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Francis%2C+A+J%3BDodge%2C+C+J%3BChatterjee%2C+S%3BLandry%2C+M+F&rft.aulast=Francis&rft.aufirst=A&rft.date=1994-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Citrate+biodegradation%3B+mid-year+status+report%2C+%28January+1994-June+1994%29&rft.title=Citrate+biodegradation%3B+mid-year+status+report%2C+%28January+1994-June+1994%29&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1998-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE95002243NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Progress report; Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - actinides; biodegradation; metals; microorganisms; pollutants; pollution; progress report; remediation; report; soil treatment; soils; solid waste; toxic materials; uranium; waste disposal ER - TY - JOUR T1 - Physiological limitation of phytoplankton photosynthesis in the eastern equatorial Pacific determined from variability in the quantum yield of fluorescence AN - 1808648461; PQ0003340607 AB - On a transect study in the eastern equatorial Pacific, from the high-nutrient, low-chlorophyll tropical waters to the oligotrophic subtropical waters, we determined the variability in the maximum change in the quantum yield of chlorophyll fluorescence ( Delta sub(m) ) by means of a fast repetition rate fluorometer. Delta sub(m) is a quantitative measure of photochemical energy conversion efficiency in photosystem 2, the variability of which is determined by the functional organization of the photosynthetic apparatus. The results revealed that Delta sub(m) was relatively low throughout the nutrient-rich equatorial waters, providing unequivocal evidence for physiological limitation of photochemical energy conversion efficiency in the natural phytoplankton populations. Shipboard enrichment studies showed that Delta sub(m) increased following addition of nanomolar concentrations of inorganic iron as well as aerosol dust added at similar iron concentrations. This response reflects an iron-induced repair of photosystem 2 function in the enclosed bottle community. Low Delta sub(m) at the top of the Equatorial Undercurrent indicated that the amount of iron upwelled to the surface was insufficient to repair photosystem 2 function. Our results strongly suggest that iron availability limits photochemical energy conversion efficiency and is the principal mechanism controlling rates of photosynthesis and growth in the nutrient-rich equatorial Pacific. JF - Limnology and Oceanography AU - Greene, Richard M AU - Kolber, Zbigniew S AU - Swift, Dorothy G AU - Tindale, Neil W AU - Falkowski, Paul G AD - Oceanographic and Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1994/07// PY - 1994 DA - July 1994 SP - 1061 EP - 1074 PB - Association for the Sciences of Limnology and Oceanography VL - 39 IS - 5 SN - 0024-3590, 0024-3590 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Photochemistry KW - Chlorophylls KW - Variability KW - Chlorophyll KW - Energy Conversion KW - Photosynthesis KW - Limnology KW - Phytoplankton KW - Dust KW - Yield KW - Growth KW - IS, Equatorial Pacific KW - Functional morphology KW - Growth rate KW - Marine KW - Aerosols KW - Fluorescence KW - Photosynthetic apparatus KW - Environmental impact KW - Limiting factors KW - Photosystem KW - Fluorimeters KW - Repetition KW - AS, Atlantic, Equatorial Undercurrent KW - Energy KW - Equatorial undercurrents KW - Iron KW - Eolian dust KW - AQ 00001:Water Resources and Supplies KW - Q1 08482:Ecosystems and energetics KW - SW 0810:General KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808648461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Physiological+limitation+of+phytoplankton+photosynthesis+in+the+eastern+equatorial+Pacific+determined+from+variability+in+the+quantum+yield+of+fluorescence&rft.au=Greene%2C+Richard+M%3BKolber%2C+Zbigniew+S%3BSwift%2C+Dorothy+G%3BTindale%2C+Neil+W%3BFalkowski%2C+Paul+G&rft.aulast=Greene&rft.aufirst=Richard&rft.date=1994-07-01&rft.volume=39&rft.issue=5&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1994.39.5.1061 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Photochemistry; Growth rate; Chlorophylls; Aerosols; Fluorescence; Photosynthesis; Environmental impact; Phytoplankton; Limiting factors; Fluorimeters; Dust; Growth; Equatorial undercurrents; Eolian dust; Repetition; Chlorophyll; Energy; Photosynthetic apparatus; Functional morphology; Photosystem; Iron; Yield; Variability; Energy Conversion; Limnology; AS, Atlantic, Equatorial Undercurrent; IS, Equatorial Pacific; Marine DO - http://dx.doi.org/10.4319/lo.1994.39.5.1061 ER - TY - JOUR T1 - Expression of chicken linker histones in E. coli: sources of problems and methods for overcoming some of the difficulties. AN - 76796959; 7950367 AB - Expression of histones in Escherichia coli is important in structural studies on chromatin, because it allows isotopic labeling such as deuteration and replacement of methionines with selenomethionine as well as expression of specific domains of histones. We show that full-length H5 cannot be expressed in E. coli. We have determined that the problem is translational rather than transcriptional. Pulse-labeling studies show that protein turnover is not the reason for lack of accumulation. On dissecting the gene, we find that the problem lies in expressing the highly charged C-terminal tail of H5. We can make progressively increasing amounts of the tail, but at the point where over two-thirds of this region is transcribed, the protein ceases to be made. Surprisingly, full-length H1 is made. In vitro studies show that the H5 gene can be translated in a rabbit reticulocyte system but not in an E. coli system, suggesting that there may be a difference in the ability of eukaryotic and prokaryotic ribosomes to translate this message. The expression of the globular domains of H5 and H1 posed a different problem. There was little or no expression of some of the constructs, even though they were fragments of larger constructs that were well made. Replacement of the first five codons downstream of the initiating ATG codon with those optimized for E. coli, and which were AT rich, restored expression. This may have general implications for expression of eukaryotic proteins in E. coli. JF - Protein expression and purification AU - Gerchman, S E AU - Graziano, V AU - Ramakrishnan, V AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 242 EP - 251 VL - 5 IS - 3 SN - 1046-5928, 1046-5928 KW - Codon KW - 0 KW - Histones KW - Oligodeoxyribonucleotides KW - RNA, Messenger KW - Recombinant Proteins KW - Sulfur Radioisotopes KW - Methionine KW - AE28F7PNPL KW - Index Medicus KW - Protein Biosynthesis KW - Animals KW - Codon -- genetics KW - Electrophoresis, Polyacrylamide Gel KW - Gene Expression KW - Methionine -- metabolism KW - Cloning, Molecular -- methods KW - Transcription, Genetic KW - Rabbits KW - Amino Acid Sequence KW - Molecular Weight KW - Base Sequence KW - Blotting, Western KW - Chickens KW - RNA, Messenger -- metabolism KW - Reading Frames KW - Restriction Mapping KW - Reticulocytes -- metabolism KW - Escherichia coli KW - Molecular Sequence Data KW - Mutagenesis, Insertional KW - Recombinant Proteins -- isolation & purification KW - Recombinant Proteins -- biosynthesis KW - Histones -- biosynthesis KW - Histones -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76796959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+expression+and+purification&rft.atitle=Expression+of+chicken+linker+histones+in+E.+coli%3A+sources+of+problems+and+methods+for+overcoming+some+of+the+difficulties.&rft.au=Gerchman%2C+S+E%3BGraziano%2C+V%3BRamakrishnan%2C+V&rft.aulast=Gerchman&rft.aufirst=S&rft.date=1994-06-01&rft.volume=5&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Protein+expression+and+purification&rft.issn=10465928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-11-29 N1 - Date created - 1994-11-29 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Technical guidelines for aseismic design of nuclear power plants; translation of JEAG 4601-1987 AN - 51056446; 1996-038159 AB - The document is a translation, in its entirety, of the Japan Electric Association (JEA) publication entitled Technical Guidelines for Aseismic Design of Nuclear Power Plants, JEAG 4601-1987. This guideline describes in detail the aseismic design techniques used in Japan for nuclear power plants. It contains chapters dealing with the selection of earthquake ground motions for a site, the investigation of foundation and bedrock conditions, the evaluation of ground stability and the effects of ground movement on buried piping and structures, the analysis and design of structures, and the analysis and design of equipment and distribution systems (piping, electrical raceways, instrumentation, tubing and HVAC duct). The guideline also includes appendices which summarize data, information and references related to aseismic design technology. JF - NUREG/CR (United States. Nuclear Regulatory Commission) AU - Park, Y J AU - Hofmayer, C H Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 959 PB - U. S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, Washington, DC SN - 0278-1670, 0278-1670 KW - soil mechanics KW - Far East KW - dynamic loading KW - loading KW - stress KW - power plants KW - seismic response KW - structures KW - foundations KW - soil-structure interface KW - safety KW - seismicity KW - ground motion KW - buildings KW - nuclear facilities KW - aseismic design KW - Asia KW - earthquakes KW - Japan KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51056446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Park%2C+Y+J%3BHofmayer%2C+C+H&rft.aulast=Park&rft.aufirst=Y&rft.date=1994-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Technical+guidelines+for+aseismic+design+of+nuclear+power+plants%3B+translation+of+JEAG+4601-1987&rft.title=Technical+guidelines+for+aseismic+design+of+nuclear+power+plants%3B+translation+of+JEAG+4601-1987&rft.issn=02781670&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1996-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number NUREG/CR-6241NEG, Springfield, VA, United States N1 - PubXState - DC N1 - SuppNotes - Translated from the Japanese N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aseismic design; Asia; buildings; design; dynamic loading; earthquakes; Far East; foundations; ground motion; Japan; loading; nuclear facilities; power plants; safety; seismic response; seismicity; soil mechanics; soil-structure interface; stress; structures ER - TY - JOUR T1 - Single-cell RNA content of natural marine planktonic bacteria measured by hybridization with multiple 16S rRNA-targeted fluorescent probes AN - 1808640416; PQ0003340584 AB - Despite the potential of cellular RNA as a tool for the study of bacterial activities in natural environments, cellular RNA has rarely been measured because of methodological limitations. In a previous study, we quantitatively analyzed single-cell RNA content with multiple 16S rRNA-targeted fluorescent probes. In the present study, we explore the potential of this approach with 12 samples of natural planktonic bacteria collected from coastal water over a 6-month period (late winter to summer). We measured fluorescence from single cells hybridized with multiple probes, cellular DNA and RNA by ethidium bromide (EtBr) fluorometry, and [ super(3)H]thymidine (TdR) incorporation rates. Fluorescence of the probe-hybridized cells was highly correlated to cellular RNA determined by EtBr fluorometry. Winter and summer samples showed different patterns of fluorescence-frequency distribution. Temperature had a large positive effect on TdR incorporation rates, but there was a negative correlation with cellular RNA content; only the samples taken at elevated summer temperatures showed a positive relationship between TdR incorporation and cellular RNA content. We estimated that the RNA content of the cells not visibly labeled with five probes was <0.3 fg. JF - Limnology and Oceanography AU - Lee, SangHoon AU - Kemp, Paul F AD - Oceanographic and Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 869 EP - 879 PB - Association for the Sciences of Limnology and Oceanography VL - 39 IS - 4 SN - 0024-3590, 0024-3590 KW - Biochemistry Abstracts 2: Nucleic Acids; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Coastal Waters KW - DNA probes KW - Ecological distribution KW - Probes KW - Limnology KW - Hybridization KW - Distribution Patterns KW - Bromides KW - Fluorescent indicators KW - Abiotic factors KW - Temperature effects KW - Marine KW - Bacteria KW - Plankton surveys KW - Fluorescence KW - Temperature KW - Oceanography KW - Coastal waters KW - RNA KW - Ethidium bromide KW - DNA KW - Fluorometry KW - Nucleic acids KW - Plankton KW - AQ 00001:Water Resources and Supplies KW - Q1 08563:Fishing gear and methods KW - SW 0810:General KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808640416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Single-cell+RNA+content+of+natural+marine+planktonic+bacteria+measured+by+hybridization+with+multiple+16S+rRNA-targeted+fluorescent+probes&rft.au=Lee%2C+SangHoon%3BKemp%2C+Paul+F&rft.aulast=Lee&rft.aufirst=SangHoon&rft.date=1994-06-01&rft.volume=39&rft.issue=4&rft.spage=869&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1994.39.4.0869 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Temperature effects; Plankton surveys; RNA; Bromides; Ecological distribution; DNA; Hybridization; Plankton; Nucleic acids; Abiotic factors; Fluorescence; DNA probes; Ethidium bromide; Fluorescent indicators; Fluorometry; Coastal waters; Distribution Patterns; Bacteria; Coastal Waters; Temperature; Probes; Limnology; Oceanography; Marine DO - http://dx.doi.org/10.4319/lo.1994.39.4.0869 ER - TY - JOUR T1 - Influence of radiation fractionation on survival of mice and spleen colony-forming units. AN - 76495263; 8183997 AB - C57Bl/6 mice were given 10 Gy X rays fractionated in several ways. There was a cyclical pattern of animal survival which was correlated to the fractionation interval and which indicated a periodicity of 6 h. Ten grays given in a single dose is fatal to 100% of the mice and depresses the CFU-S to about one per leg with no evidence of proliferation during the remaining life. Ten grays given in 2.5-Gy increments at 24-h intervals causes no fatalities and results in a similar CFU-S depression but is followed by an exponential increase in CFU-S over the ensuing 12 days. Although bone marrow from survivors of such treatment was comparable to control marrow in its capacity for short-term rescue, it was clearly inferior in its capacity for long-term rescue. The periodicity of 6 h suggests that the cells responsible for survival of the mice have been synchronized into more or less radiosensitive and radioresistant stages of the cell cycle as a result of the time between the 2.5-Gy increments. Implications for the CFU-S and long-term repopulating cells are discussed. JF - Radiation research AU - Cronkite, E P AU - Inoue, T AU - Bullis, J E AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1994/05// PY - 1994 DA - May 1994 SP - 266 EP - 271 VL - 138 IS - 2 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Bone Marrow Cells KW - Animals KW - Whole-Body Irradiation -- methods KW - Spleen -- radiation effects KW - Spleen -- cytology KW - Mice, Inbred C57BL KW - Mice KW - Bone Marrow -- radiation effects KW - Colony-Forming Units Assay KW - Survival Analysis KW - Dose-Response Relationship, Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76495263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Influence+of+radiation+fractionation+on+survival+of+mice+and+spleen+colony-forming+units.&rft.au=Cronkite%2C+E+P%3BInoue%2C+T%3BBullis%2C+J+E&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1994-05-01&rft.volume=138&rft.issue=2&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-06-14 N1 - Date created - 1994-06-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Temporal changes in the incidence of malignant melanoma: explanation from action spectra. AN - 76487302; 7513817 AB - The incidence of malignant cutaneous melanoma has been increasing for more than 50 years, and is now rising more rapidly than that of any other cancer. This increase is not explicable by changes in the physical environment, particularly by any observed increase in UVB radiation (290-320 nm). The distribution of melanomas on the body differs from the site distribution of nonmelanoma skin cancer (relatively many more melanomas occur on areas of the body not chronically exposed to sunlight, such as the back of the trunk in males, and the legs in females). This localization of melanoma, together with its epidemiology, suggest that a change in lifestyle has contributed to the fast-rising incidence in many countries. There is no convenient mammalian animal model for malignant melanoma. However, certain inter- and intra-specific hybrids of fish of the genus Xiphophorus are very sensitive to light-induced melanomas; we have used them to determine the wavelengths effective in melanoma induction. The action spectrum has a relatively very large component in the UVA region (320-400 nm) compared to human erythema. Hence, if the human and fish spectra were similar, the use of sunscreens that minimize erythema would have little effect in preventing the induction of melanoma, and if people using sunscreens expose themselves to sunlight for longer periods, they will be increasing dramatically their exposure to these melanoma-inducing wavelengths. Such considerations are sufficient to explain the rising incidence of malignant melanoma and its distribution on the body. JF - Mutation research AU - Setlow, R B AU - Woodhead, A D AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1994/05/01/ PY - 1994 DA - 1994 May 01 SP - 365 EP - 374 VL - 307 IS - 1 SN - 0027-5107, 0027-5107 KW - Sunscreening Agents KW - 0 KW - Index Medicus KW - Life Style KW - Animals KW - Ultraviolet Rays KW - Cyprinodontiformes KW - Humans KW - Melanoma, Experimental KW - Incidence KW - Disease Models, Animal KW - Male KW - Female KW - Sunscreening Agents -- adverse effects KW - Skin Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- epidemiology KW - Melanoma -- etiology KW - Skin Neoplasms -- epidemiology KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76487302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Temporal+changes+in+the+incidence+of+malignant+melanoma%3A+explanation+from+action+spectra.&rft.au=Setlow%2C+R+B%3BWoodhead%2C+A+D&rft.aulast=Setlow&rft.aufirst=R&rft.date=1994-05-01&rft.volume=307&rft.issue=1&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-06-09 N1 - Date created - 1994-06-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - PET studies of cocaine inhibition of myocardial norepinephrine uptake. AN - 76653087; 8059340 AB - Positron emission tomography (PET), [11C]cocaine, and (-)-6-[18F]fluoronorepinephrine [(-)-6-[18F]NE] were used to determine the extent to which the binding of labeled cocaine in the baboon heart represents binding to the norepinephrine transporter and to characterize the functional consequences of cocaine administration on the norepinephrine transporter. Peak heart binding of [11C]cocaine was high (0.038-0.055%/g) and clearance was rapid (t1/2 from peak: 2.5-9 min) for both tracer doses and a pharmacological dose. The binding of a tracer dose of labeled cocaine could not be inhibited by desipramine, tomoxetine, cocaine, nomifensine, or benztropine. The behavior of a pharmacological dose of [11C]cocaine could not be distinguished from a tracer dose and also could not be inhibited by tomoxetine. However, pretreatment with cocaine profoundly inhibited norepinephrine uptake as assessed by (-)-6-[18F]NE. Recovery was slow with only 48% of the baseline (-)-6-[18F]NE uptake being recovered by 78 minutes after cocaine administration. [11C]Benzoylecgonine, a vasoactive metabolite of cocaine, showed negligible retention in heart. The results of this study (i.e., the rapid clearance of cocaine from the heart, the inability to inhibit cocaine binding with desipramine and tomoxetine, and its relatively long-lasting effects on norepinephrine uptake) reinforce the need to understand the link between cocaine pharmacokinetics and norepinephrine transporter function and its relationship to cardiotoxicity. JF - Synapse (New York, N.Y.) AU - Fowler, J S AU - Ding, Y S AU - Volkow, N D AU - Martin, T AU - MacGregor, R R AU - Dewey, S AU - King, P AU - Pappas, N AU - Alexoff, D AU - Shea, C AD - Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1994/04// PY - 1994 DA - April 1994 SP - 312 EP - 317 VL - 16 IS - 4 SN - 0887-4476, 0887-4476 KW - Cocaine KW - I5Y540LHVR KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Papio KW - Animals KW - Drug Interactions KW - Tomography, Emission-Computed KW - Heart -- diagnostic imaging KW - Norepinephrine -- metabolism KW - Heart -- drug effects KW - Cocaine -- pharmacokinetics KW - Cocaine -- pharmacology KW - Myocardium -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76653087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=PET+studies+of+cocaine+inhibition+of+myocardial+norepinephrine+uptake.&rft.au=Fowler%2C+J+S%3BDing%2C+Y+S%3BVolkow%2C+N+D%3BMartin%2C+T%3BMacGregor%2C+R+R%3BDewey%2C+S%3BKing%2C+P%3BPappas%2C+N%3BAlexoff%2C+D%3BShea%2C+C&rft.aulast=Fowler&rft.aufirst=J&rft.date=1994-04-01&rft.volume=16&rft.issue=4&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-09-15 N1 - Date created - 1994-09-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Carbon tetrachloride and chlorofluorocarbons in the South Atlantic Ocean, 19 degrees S AN - 51019306; 1999-060891 AB - Exploratory measurements of a suite of anthropogenic halocarbon compounds (CCl (sub 4) , CCl (sub 2) FCClF (sub ) 2 (CFC-113), CH (sub 3) CCl (sub 3) , CCl (sub 3) F (CFC-11)) were made using a new analytical technique on RV Meteor cruise 15 along 19 degrees S (World Ocean Circulation Experiment (WOCE) Line A9)) in the Atlantic Ocean during February-March 1991. A separate analytical system was used to determine CCl (sub 2) F (sub 2) (CFC-12) and CCl (sub 3) F (CFC-11). A limited number of CFC-113 profiles indicated that it was undetectable below 400-500 m. The CCl (sub 4) data indicate that the entire Brazil Basin contains readily measurable levels of CCl (sub 4) (>0.05 pmol kg (super -1) ), whereas the deep Angola Basin contains very low levels (1000 m) had undetectable levels of CFC-11, CFC-12, and CFC-113. Preindustrial levels of CCl (sub 4) in the atmosphere were therefore negligible (atmospheric mixing ratio <0.1 pptv). CCl (sub 4) /CFC-11 ratios are used to estimate apparent ages and dilution factors for the North Atlantic Deep Water and Antarctic Bottom Water. Whereas CCl (sub 4) /CFC-11/CFC-12 levels are internally consistent in deep waters, suggesting near-conservative behavior, there is evidence for very rapid removal of CCl (sub 4) in the thermocline. Removal rates suggest that in addition to neutral hydrolysis, some other loss pathway must be involved. JF - Journal of Geophysical Research AU - Wallace, Douglas W R AU - Beining, Peter AU - Putzka, Alfred Y1 - 1994/04// PY - 1994 DA - April 1994 SP - 7803 EP - 7819 PB - American Geophysical Union, Washington, DC VL - 99 IS - C4 SN - 0148-0227, 0148-0227 KW - methods KW - chlorinated hydrocarbons KW - relative age KW - CFC-113 KW - sea water KW - Brazil Basin KW - hydrolysis KW - chlorofluorocarbons KW - geochronology KW - Antarctic Bottom Water KW - tracers KW - halogenated hydrocarbons KW - CFC-11 KW - geochemistry KW - ocean circulation KW - Angola Basin KW - background level KW - atmosphere KW - depth KW - geochemical cycle KW - carbon tetrachloride KW - Antarctic Intermediate Water KW - organic compounds KW - thermocline KW - North Atlantic Deep Water KW - South Atlantic KW - Atlantic Ocean KW - 03:Geochronology KW - 02C:Geochemistry of rocks, soils, and sediments KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51019306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Carbon+tetrachloride+and+chlorofluorocarbons+in+the+South+Atlantic+Ocean%2C+19+degrees+S&rft.au=Wallace%2C+Douglas+W+R%3BBeining%2C+Peter%3BPutzka%2C+Alfred&rft.aulast=Wallace&rft.aufirst=Douglas+W&rft.date=1994-04-01&rft.volume=99&rft.issue=C4&rft.spage=7803&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F94JC00031 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 43 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Angola Basin; Antarctic Bottom Water; Antarctic Intermediate Water; Atlantic Ocean; atmosphere; background level; Brazil Basin; carbon tetrachloride; CFC-11; CFC-113; chlorinated hydrocarbons; chlorofluorocarbons; depth; geochemical cycle; geochemistry; geochronology; halogenated hydrocarbons; hydrolysis; methods; North Atlantic Deep Water; ocean circulation; organic compounds; relative age; sea water; South Atlantic; thermocline; tracers DO - http://dx.doi.org/10.1029/94JC00031 ER - TY - JOUR T1 - Models for simulating the release and migration of radionuclides from low-level waste disposal facilities AN - 50085579; 1996-001027 JF - Eos, Transactions, American Geophysical Union AU - MacKinnon, R J AU - Sullivan, T M AU - Suen, C J AU - Anonymous Y1 - 1994/04// PY - 1994 DA - April 1994 SP - 171 PB - American Geophysical Union, Washington, DC VL - 75 IS - 16, Suppl. SN - 0096-3941, 0096-3941 KW - migration KW - sorption KW - isotopes KW - complexing KW - statistical analysis KW - unsaturated zone KW - prediction KW - solution KW - simulation KW - radioactive waste KW - models KW - finite element analysis KW - saturated zone KW - radioactive isotopes KW - transport KW - precipitation KW - movement KW - applications KW - ion exchange KW - algorithms KW - waste disposal KW - low-level waste KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50085579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Models+for+simulating+the+release+and+migration+of+radionuclides+from+low-level+waste+disposal+facilities&rft.au=MacKinnon%2C+R+J%3BSullivan%2C+T+M%3BSuen%2C+C+J%3BAnonymous&rft.aulast=MacKinnon&rft.aufirst=R&rft.date=1994-04-01&rft.volume=75&rft.issue=16%2C+Suppl.&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1994 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - algorithms; applications; complexing; finite element analysis; ion exchange; isotopes; low-level waste; migration; models; movement; precipitation; prediction; radioactive isotopes; radioactive waste; saturated zone; simulation; solution; sorption; statistical analysis; transport; unsaturated zone; waste disposal ER - TY - JOUR T1 - Design criteria for prompt radiation limits on the relativistic heavy ion collider site. AN - 76354976; 8106249 AB - The Relativistic Heavy Ion Collider (RHIC) is a superconducting colliding beam accelerator facility that is currently under construction. Relatively small amounts of energy depositing in the coils of superconducting magnets can result in a "quench," the irreversible transition to the normal resistive state. The quench limit of superconducting magnets, therefore, constrains local beam loss throughout the injection, acceleration, and storage cycles to extremely low levels. From a practical standpoint, it follows that there is essentially no prompt radiation in most regions due to normal operations. The design of shielding is, therefore, principally driven by the consequences of a single pulse fault at full energy in one of the two storage rings. Since there are no regulatory requirements or guidance documents that prescribe radiological performance goals for this situation, the RHIC Project has proposed a scheme to classify the various areas of the RHIC complex based on Design Basis Accident faults. The criteria is then compared to existing regulatory requirements and guidance recommendations. JF - Health physics AU - Stevens, A AU - Musolino, S AU - Harrison, M AD - Brookhaven National Laboratory, RHIC Project, Upton, NY 11973. Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 300 EP - 304 VL - 66 IS - 3 SN - 0017-9078, 0017-9078 KW - Ions KW - 0 KW - Index Medicus KW - Space life sciences KW - Equipment Design KW - Radiation Protection KW - Particle Accelerators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76354976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Design+criteria+for+prompt+radiation+limits+on+the+relativistic+heavy+ion+collider+site.&rft.au=Stevens%2C+A%3BMusolino%2C+S%3BHarrison%2C+M&rft.aulast=Stevens&rft.aufirst=A&rft.date=1994-03-01&rft.volume=66&rft.issue=3&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-24 N1 - Date created - 1994-03-24 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Hydrodynamic effects in tanks containing layered liquids AN - 52838400; 1996-043471 AB - As a supplement to a recently reported study, the hydrodynamic wall pressures and the associated tank forces induced by horizontal ground shaking in a rigid, vertical, circular cylindrical tank containing liquid layers of different thickness and mass densities are examined, and comprehensive numerical solutions are presented for two-layered and some three-layered systems which elucidate the underlying response mechanisms and the effects of the various parameters involved. Both the impulsive and convective actions are studied. Additionally, solutions are presented for multi-layered systems approximating liquid wit an exponential, continuous variation in density, and the interrelationship of the solutions for the continuous system and its discretized, layered approximation is discussed. JF - BNL (Brookhaven National Laboratory) AU - Veletsos, A AU - Shivakumar, P AU - Bandyopadhyay, K Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 55 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - numerical models KW - underground storage tanks KW - fluid dynamics KW - seismic response KW - preventive measures KW - layered materials KW - rock mechanics KW - radioactive waste KW - soil-structure interface KW - safety KW - ground motion KW - vibration KW - hydrodynamics KW - waste disposal KW - earthquakes KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52838400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Veletsos%2C+A%3BShivakumar%2C+P%3BBandyopadhyay%2C+K&rft.aulast=Veletsos&rft.aufirst=A&rft.date=1994-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Hydrodynamic+effects+in+tanks+containing+layered+liquids&rft.title=Hydrodynamic+effects+in+tanks+containing+layered+liquids&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1996-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE94009948NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - earthquakes; fluid dynamics; ground motion; hydrodynamics; layered materials; numerical models; preventive measures; radioactive waste; rock mechanics; safety; seismic response; soil-structure interface; underground storage tanks; vibration; waste disposal ER - TY - JOUR T1 - Metamorphism in the CO3 chondrites; trace element behavior in matrices and rims AN - 52786083; 1996-076815 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Brearley, Adrian J AU - Bajt, Sasa AU - Sutton, Steve R AU - Anonymous Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 167 EP - 168 PB - Lunar and Planetary Science Conference, Houston, TX VL - 25, Part 1 KW - stony meteorites KW - CO3 chondrites KW - carbonaceous chondrites KW - Kainsaz Meteorite KW - metamorphism KW - equilibrium KW - Warrenton Meteorite KW - CO chondrites KW - Ornans Meteorite KW - meteorites KW - Allan Hills Meteorites KW - ALHA 77307 KW - trace elements KW - chondrites KW - zoning KW - 05B:Petrology of meteorites and tektites KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52786083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Metamorphism+in+the+CO3+chondrites%3B+trace+element+behavior+in+matrices+and+rims&rft.au=Brearley%2C+Adrian+J%3BBajt%2C+Sasa%3BSutton%2C+Steve+R%3BAnonymous&rft.aulast=Brearley&rft.aufirst=Adrian&rft.date=1994-03-01&rft.volume=25%2C+Part+1&rft.issue=&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-fifth lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 5 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - ALHA 77307; Allan Hills Meteorites; carbonaceous chondrites; chondrites; CO chondrites; CO3 chondrites; equilibrium; Kainsaz Meteorite; metamorphism; meteorites; Ornans Meteorite; stony meteorites; trace elements; Warrenton Meteorite; zoning ER - TY - JOUR T1 - Enumeration and characterization of microorganisms associated with the uranium ore deposit at Cigar Lake, Canada; Informal report AN - 52770347; 1997-001972 AB - The high-grade uranium deposit at Cigar Lake, Canada, is being investigated as a natural analog for the disposal of nuclear fuel waste. Geochemical aspects of the site have been studied in detail, but the microbial ecology has not been fully investigated. Microbial populations in an ore sample and in groundwater samples from the vicinity of the ore zone were examined to determine their effect on uranium mobility. Counts of the total number of bacteria and of respiring bacteria were obtained by direct microscopy, and the viable aerobic and anaerobic bacteria were assessed as colony forming units (CFUs) by the dilution plating technique. In addition, the population distribution of denitrifiers, fermenters, iron- and sulfur-oxidizers, iron- and sulfate-reducers, and methanogens was determined by the most probable number (MPN) technique. JF - BNL (Brookhaven National Laboratory) AU - Francis, A J AU - Joshi-Tope, G AU - Gillow, J B AU - Dodge, C J Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 42 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - thallophytes KW - high-level waste KW - biodegradation KW - Plantae KW - isotopes KW - site exploration KW - pollutants KW - pollution KW - migration of elements KW - Cigar Lake KW - preventive measures KW - radioactive waste KW - ground water KW - models KW - uranium ores KW - radioactive isotopes KW - Canada KW - deposition KW - bacteria KW - metal ores KW - Western Canada KW - waste disposal KW - Saskatchewan KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52770347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Francis%2C+A+J%3BJoshi-Tope%2C+G%3BGillow%2C+J+B%3BDodge%2C+C+J&rft.aulast=Francis&rft.aufirst=A&rft.date=1994-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Enumeration+and+characterization+of+microorganisms+associated+with+the+uranium+ore+deposit+at+Cigar+Lake%2C+Canada%3B+Informal+report&rft.title=Enumeration+and+characterization+of+microorganisms+associated+with+the+uranium+ore+deposit+at+Cigar+Lake%2C+Canada%3B+Informal+report&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1997-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE94016231NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - bacteria; biodegradation; Canada; Cigar Lake; deposition; ground water; high-level waste; isotopes; metal ores; migration of elements; models; Plantae; pollutants; pollution; preventive measures; radioactive isotopes; radioactive waste; Saskatchewan; site exploration; thallophytes; uranium ores; waste disposal; Western Canada ER - TY - JOUR T1 - Microanalysis of iron oxidation states using X-ray absorption spectroscopy AN - 50412138; 2009-059418 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Sutton, S R AU - Bajt, S AU - Delaney, J S AU - Anonymous Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 1361 EP - 1362 PB - Lunar and Planetary Science Conference, Houston, TX VL - 25, Part 3 KW - silicates KW - oxygen KW - olivine group KW - mapping KW - cosmochemistry KW - analysis KW - X-ray spectra KW - iron KW - fugacity KW - observations KW - XANES spectra KW - nesosilicates KW - absorption KW - mineral composition KW - metals KW - olivine KW - orthosilicates KW - X-ray analysis KW - spectra KW - mineral assemblages KW - spectroscopy KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50412138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Microanalysis+of+iron+oxidation+states+using+X-ray+absorption+spectroscopy&rft.au=Sutton%2C+S+R%3BBajt%2C+S%3BDelaney%2C+J+S%3BAnonymous&rft.aulast=Sutton&rft.aufirst=S&rft.date=1994-03-01&rft.volume=25%2C+Part+3&rft.issue=&rft.spage=1361&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-fifth lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Number of references - 5 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - absorption; analysis; cosmochemistry; fugacity; iron; mapping; metals; mineral assemblages; mineral composition; nesosilicates; observations; olivine; olivine group; orthosilicates; oxygen; silicates; spectra; spectroscopy; X-ray analysis; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Can we model Darwin? AN - 50224652; 1994-043350 JF - New Scientist (1971) AU - Bak, Per AU - Flyvbjerg, Henrik AU - Sneppen, Kim Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 36 EP - 39 PB - New Science Publications, London VL - 141 IS - 1916 SN - 0262-4079, 0262-4079 KW - geologic hazards KW - popular geology KW - mutation KW - data processing KW - random numbers KW - biologic evolution KW - simulation KW - paleontology KW - life origin KW - models KW - computer programs KW - Darwin, Charles KW - punctuated equilibria KW - fossils KW - Game of Life KW - catastrophes KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50224652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+Scientist+%281971%29&rft.atitle=Can+we+model+Darwin%3F&rft.au=Bak%2C+Per%3BFlyvbjerg%2C+Henrik%3BSneppen%2C+Kim&rft.aulast=Bak&rft.aufirst=Per&rft.date=1994-03-01&rft.volume=141&rft.issue=1916&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=New+Scientist+%281971%29&rft.issn=02624079&rft_id=info:doi/ L2 - http://www.newscientist.com/home.ns LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - NWSCAL N1 - SubjectsTermNotLitGenreText - biologic evolution; catastrophes; computer programs; Darwin, Charles; data processing; fossils; Game of Life; geologic hazards; life origin; models; mutation; paleontology; popular geology; punctuated equilibria; random numbers; simulation ER - TY - JOUR T1 - Quantitative autoradiographic measurement of cocaine-induced regional myocardial metabolic changes in hypertensive rats. AN - 77108409; 9234289 AB - A rat model of hypertensive cardiomyopathy was studied to evaluate the acute effects of cocaine on the myocardium. Using autoradiographic microimaging techniques, myocardial perfusion (201Tl) and energy substrate utilization (glucose: [14C]2-fluoro-2-deoxy-D-glucose-[14C]2DG and fatty acid (15-[p-iodophenyl])-3-R,S-methyl pentadecanoic acid-[131I]BMIPP) were studied in Dahl strain salt-sensitive normotensive and hypertensive rats with and without intravenous cocaine. The right ventricle, septum, endocardium and epicardium of the left ventricle were analyzed. Increased perfusion (18%) was seen in the myocardium of the hypertensive rats as compared to the normotensive rats. There was higher [14C]2DG (254%) and lower fatty acid (13.2%) uptake in the hypertensive rats, indicative of a shift from aerobic to anaerobic substrate utilization. In cocaine-treated normotensive rats, a generalized decrease in myocardial perfusion (30%) and increased glucose metabolism (89%) was seen. In cocaine-treated hypertensive rats, the increased myocardial perfusion (16%) was heterogeneous and was more pronounced in septum and epicardium. The endocardium and epicardium in the hypertensive rats showed an overall increase (23%) in glucose utilization after cocaine which was not as dramatic as was seen in the normotensive heart and a slight increase in fatty acid utilization. These results are consistent with prior observations that under pressure overload the myocardium responds non-uniformly. It may well be that the hypertensive cardiomyopathic heart is unable to respond to the challenge of cocaine by further increasing glucose utilization. These data obtained in an animal model of hypertension seem to indicate that hypertension may increase the risk of cardiac complications related to cocaine. JF - Nuclear medicine and biology AU - Wang, G J AU - Som, P AU - Oster, Z H AU - Volkow, N D AU - Knapp, F F AU - Sacker, D F AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 245 EP - 250 VL - 21 IS - 2 SN - 0969-8051, 0969-8051 KW - Narcotics KW - 0 KW - Sodium Chloride, Dietary KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Cardiomyopathies -- metabolism KW - Risk Factors KW - Humans KW - Disease Models, Animal KW - Cardiomyopathies -- chemically induced KW - Substance-Related Disorders -- metabolism KW - Sodium Chloride, Dietary -- administration & dosage KW - Autoradiography KW - Myocardium -- metabolism KW - Heart -- drug effects KW - Cocaine -- pharmacology KW - Narcotics -- pharmacology KW - Hypertension -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77108409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+medicine+and+biology&rft.atitle=Quantitative+autoradiographic+measurement+of+cocaine-induced+regional+myocardial+metabolic+changes+in+hypertensive+rats.&rft.au=Wang%2C+G+J%3BSom%2C+P%3BOster%2C+Z+H%3BVolkow%2C+N+D%3BKnapp%2C+F+F%3BSacker%2C+D+F&rft.aulast=Wang&rft.aufirst=G&rft.date=1994-02-01&rft.volume=21&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Nuclear+medicine+and+biology&rft.issn=09698051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-25 N1 - Date created - 1997-09-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Recovery of brain glucose metabolism in detoxified alcoholics. AN - 76343035; 8296885 AB - OBJECTIVETo differentiate withdrawal-related abnormalities in brain glucose metabolism among alcoholics from abnormalities that may be irreversible or antedate alcohol use, the authors evaluated metabolic recovery during alcohol detoxification.METHODRegional brain glucose metabolism was measured with positron emission tomography and 2-deoxy-2-[18F]fluoro-D-glucose in 10 male alcoholics at 8-15 days, 16-30 days, and 31-60 days after last use of alcohol. The alcoholics' metabolic values were compared with those of 10 age-matched male healthy volunteers.RESULTSBrain metabolism increased significantly during detoxification. There were significant differences in global and regional measures between the first and last time points but not between the second and third points, suggesting that recovery occurred predominantly within 16-30 days. Regional increases in metabolism were greater in the frontal regions. Whereas during the first evaluation the alcoholics showed significantly lower metabolism in various brain regions than the comparison group, at the end of detoxification the alcoholics showed significantly lower absolute and relative metabolic values in the basal ganglia and lower relative metabolic values in the parietal cortex. Among the alcoholics, but not the comparison group, metabolism in the frontal, parietal, and left temporal cortexes was negatively correlated with years of alcohol use and with age.CONCLUSIONSThis study shows significant increases in brain metabolism during alcohol withdrawal and documents persistent low metabolic levels in the basal ganglia of detoxified alcoholics. JF - The American journal of psychiatry AU - Volkow, N D AU - Wang, G J AU - Hitzemann, R AU - Fowler, J S AU - Overall, J E AU - Burr, G AU - Wolf, A P AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 178 EP - 183 VL - 151 IS - 2 SN - 0002-953X, 0002-953X KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Tomography, Emission-Computed KW - Alcohol Drinking KW - Male KW - Parietal Lobe -- metabolism KW - Basal Ganglia -- metabolism KW - Alcoholism -- rehabilitation KW - Substance Withdrawal Syndrome -- diagnostic imaging KW - Substance Withdrawal Syndrome -- metabolism KW - Alcoholism -- diagnostic imaging KW - Glucose -- metabolism KW - Alcoholism -- metabolism KW - Brain -- metabolism KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76343035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Recovery+of+brain+glucose+metabolism+in+detoxified+alcoholics.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BHitzemann%2C+R%3BFowler%2C+J+S%3BOverall%2C+J+E%3BBurr%2C+G%3BWolf%2C+A+P&rft.aulast=Volkow&rft.aufirst=N&rft.date=1994-02-01&rft.volume=151&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-02-25 N1 - Date created - 1994-02-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Brain-imaging studies of the combined use of cocaine and alcohol and of the pharmacokinetics of cocaethylene. AN - 77108651; 7603544 JF - NIDA research monograph AU - Volkow, N D AU - Fowler, J S AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 1994 PY - 1994 DA - 1994 SP - 41 EP - 56 VL - 138 SN - 1046-9516, 1046-9516 KW - Dopamine Uptake Inhibitors KW - 0 KW - Ethanol KW - 3K9958V90M KW - cocaethylene KW - FJO3071W5Y KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Papio KW - Animals KW - Drug Interactions KW - Half-Life KW - Humans KW - Adult KW - Metabolic Clearance Rate KW - Tissue Distribution KW - Male KW - Female KW - Cocaine -- analogs & derivatives KW - Ethanol -- pharmacology KW - Brain -- drug effects KW - Tomography, Emission-Computed KW - Cocaine -- pharmacokinetics KW - Brain -- metabolism KW - Dopamine Uptake Inhibitors -- pharmacokinetics KW - Cocaine -- blood KW - Cocaine -- adverse effects KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77108651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Brain-imaging+studies+of+the+combined+use+of+cocaine+and+alcohol+and+of+the+pharmacokinetics+of+cocaethylene.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S&rft.aulast=Volkow&rft.aufirst=N&rft.date=1994-01-01&rft.volume=138&rft.issue=&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-08-10 N1 - Date created - 1995-08-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Spacing effects on seismic responses of underground waste storage tanks AN - 52839978; 1996-043472 AB - In this paper, an investigation is performed for determination of the effects of spacing on seismic response of grouped underground tank structures. The study is carried out using a 2-D Finite Element Method, and the key mechanisms for transmitting structure-soil-structure interaction (SSSI) effects are identified. A parametric analysis is performed to quantify the SSSI effects. Results of the study are presented. JF - BNL (Brookhaven National Laboratory) AU - Xu, J AU - Bandyopadhyay, K AU - Miller, C A AU - Costantino, C J Y1 - 1994 PY - 1994 DA - 1994 SP - 6 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - underground storage KW - underground storage tanks KW - statistical analysis KW - seismic response KW - preventive measures KW - two-dimensional models KW - radioactive waste KW - finite element analysis KW - soil-structure interface KW - safety KW - underground installations KW - ground motion KW - waste disposal KW - earthquakes KW - construction KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52839978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Xu%2C+J%3BBandyopadhyay%2C+K%3BMiller%2C+C+A%3BCostantino%2C+C+J&rft.aulast=Xu&rft.aufirst=J&rft.date=1994-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Spacing+effects+on+seismic+responses+of+underground+waste+storage+tanks&rft.title=Spacing+effects+on+seismic+responses+of+underground+waste+storage+tanks&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1996-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE94011738NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Presented at the Pressure vessel and piping conference, Minneapolis, MN, June 19-24, 1994; Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - construction; earthquakes; finite element analysis; ground motion; preventive measures; radioactive waste; safety; seismic response; soil-structure interface; statistical analysis; two-dimensional models; underground installations; underground storage; underground storage tanks; waste disposal ER - TY - RPRT T1 - 5th symposium on Current issues related to nuclear power plant structure, equipment and piping AN - 52832086; 1996-047322 AB - This paper summarizes the results of recent survey studies on the available experimental data bases and design codes/standards for reinforced concrete (RC) shear wall structures in Japan. Information related to the seismic design of RC reactor buildings and containment structures was emphasized in the survey. The seismic requirements for concrete structures, particularly those related to shear strength design, are outlined. Detailed descriptions are presented on the development of Japanese shear wall equations, design requirements for containment structures, and ductility requirements. JF - 5th symposium on Current issues related to nuclear power plant structure, equipment and piping AU - Park, Y J AU - Hofmayer, C Y1 - 1994 PY - 1994 DA - 1994 SP - 16 VL - BNL-NUREG-60983 | CONF-941227-3 KW - shear strength KW - experimental studies KW - Far East KW - geologic hazards KW - regulations KW - reinforced materials KW - power plants KW - seismic response KW - concrete KW - structures KW - nuclear facilities KW - aseismic design KW - Asia KW - earthquakes KW - Japan KW - design KW - construction materials KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52832086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Park%2C+Y+J%3BHofmayer%2C+C&rft.aulast=Park&rft.aufirst=Y&rft.date=1994-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=5th+symposium+on+Current+issues+related+to+nuclear+power+plant+structure%2C+equipment+and+piping&rft.title=5th+symposium+on+Current+issues+related+to+nuclear+power+plant+structure%2C+equipment+and+piping&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 5th symposium on Current issues related to nuclear power plant structure, equipment and piping N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1996-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE95003957NEG, Springfield, VA, United States N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Hydrogeology of the upper glacial aquifer Brookhaven National Laboratory, Upton, New York AN - 52829590; 1996-055318 JF - Geology of Long Island and Metropolitan New York AU - Paguette, Douglas E Y1 - 1994 PY - 1994 DA - 1994 SP - 80 PB - State University of New York at Stony Brook, Stony Brook, NY KW - wells KW - United States KW - water supply KW - experimental studies KW - Brookhaven National Laboratory KW - pumping KW - ground water KW - aquifers KW - Suffolk County New York KW - New York KW - levels KW - movement KW - hydraulic conductivity KW - Upton New York KW - water wells KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52829590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Paguette%2C+Douglas+E&rft.aulast=Paguette&rft.aufirst=Douglas&rft.date=1994-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Hydrogeology+of+the+upper+glacial+aquifer+Brookhaven+National+Laboratory%2C+Upton%2C+New+York&rft.title=Hydrogeology+of+the+upper+glacial+aquifer+Brookhaven+National+Laboratory%2C+Upton%2C+New+York&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geology of Long Island and Metropolitan New York N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - NY N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Self-organized criticality; consequences for statistics and predictability of earthquakes AN - 52824430; 1996-057778 AB - The concept of self-organized criticality provides a natural, robust explanation of the statistics of earthquakes, including the Gutenberg-Richter law for the distribution of earthquake magnitudes. The dynamics is "at the edge of chaos" with algebraic, not exponential, divergence of small uncertainties. Temporal clustering of big earthquakes arises because of an underlying fractal structure of correlated regions. Scaling laws suggest that the statistics of large events can be inferred from the statistics of the much more numerous small events. JF - Geophysical Monograph AU - Bak, Per AU - Christensen, Kim AU - Olami, Zeev Y1 - 1994 PY - 1994 DA - 1994 SP - 69 EP - 74 PB - American Geophysical Union, Washington, DC VL - 83 SN - 0065-8448, 0065-8448 KW - United States KW - models KW - Gutenberg-Richter Law KW - numerical models KW - self-organization KW - seismicity KW - earthquake prediction KW - statistical analysis KW - magnitude KW - earthquakes KW - New Madrid region KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52824430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Monograph&rft.atitle=Self-organized+criticality%3B+consequences+for+statistics+and+predictability+of+earthquakes&rft.au=Bak%2C+Per%3BChristensen%2C+Kim%3BOlami%2C+Zeev&rft.aulast=Bak&rft.aufirst=Per&rft.date=1994-01-01&rft.volume=83&rft.issue=&rft.spage=69&rft.isbn=9781118670019&rft.btitle=&rft.title=Geophysical+Monograph&rft.issn=00658448&rft_id=info:doi/10.1029%2FGM083p0069 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 25 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2014-03-14 N1 - CODEN - GPMGAD N1 - SubjectsTermNotLitGenreText - earthquake prediction; earthquakes; Gutenberg-Richter Law; magnitude; models; New Madrid region; numerical models; seismicity; self-organization; statistical analysis; United States DO - http://dx.doi.org/10.1029/GM083p0069 ER - TY - BOOK T1 - Use of tritium- (super 3) helium groundwater dating technique to estimate migration rates of volatile organic compounds in an unconsolidated sand and gravel aquifer system AN - 52816628; 1996-055316 JF - Geology of Long Island and Metropolitan New York AU - Naidu, J R Y1 - 1994 PY - 1994 DA - 1994 SP - 72 PB - State University of New York at Stony Brook, Stony Brook, NY KW - migration KW - isotopes KW - pollutants KW - pollution KW - tritium KW - ground water KW - aquifers KW - volatiles KW - organic compounds KW - radioactive isotopes KW - noble gases KW - hydrogen KW - movement KW - volatile organic compounds KW - helium KW - unconsolidated materials KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52816628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Naidu%2C+J+R&rft.aulast=Naidu&rft.aufirst=J&rft.date=1994-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Use+of+tritium-+%28super+3%29+helium+groundwater+dating+technique+to+estimate+migration+rates+of+volatile+organic+compounds+in+an+unconsolidated+sand+and+gravel+aquifer+system&rft.title=Use+of+tritium-+%28super+3%29+helium+groundwater+dating+technique+to+estimate+migration+rates+of+volatile+organic+compounds+in+an+unconsolidated+sand+and+gravel+aquifer+system&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geology of Long Island and Metropolitan New York N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - NY N1 - Last updated - 2012-06-07 ER - TY - RPRT T1 - Understanding earthquake design criteria used in Japan AN - 52792182; 1996-068862 AB - This paper summarizes the current earthquake design criteria used in Japan for nuclear power plants. Information is presented on the codes and standards and seismic requirements for reactor buildings and containment structures. The most interesting features of the earthquake design criteria used in Japan, in the light of those used in the United States, are summarized. JF - Understanding earthquake design criteria used in Japan AU - Hofmayer, C H AU - Park, Y J AU - Costello, J F Y1 - 1994 PY - 1994 DA - 1994 SP - 11 VL - BNL-NUREG-61147 | CONF-941227-4 KW - Far East KW - pollution KW - power plants KW - migration of elements KW - seismic response KW - preventive measures KW - controls KW - foundations KW - soil-structure interface KW - safety KW - nuclear facilities KW - aseismic design KW - Asia KW - earthquakes KW - Japan KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52792182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hofmayer%2C+C+H%3BPark%2C+Y+J%3BCostello%2C+J+F&rft.aulast=Hofmayer&rft.aufirst=C&rft.date=1994-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Understanding+earthquake+design+criteria+used+in+Japan&rft.title=Understanding+earthquake+design+criteria+used+in+Japan&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1996-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE95004837NEG, Springfield, VA, United States N1 - SuppNotes - Presented at the 5th symposium on Current issues related to nuclear power plant structure, equipment and piping, Orlando, FL, Dec. 14-16, 1994; Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Influence of sulphur cross-linking on the molecular size distribution of sulphur-rich macromolecules in bitumen AN - 52722118; 1997-038793 JF - ACS Symposium Series AU - Schouten, Stefan AU - Eglinton, Timothy I AU - Sinninghe Damste, Jaap S AU - de Leeuw, Jan W A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 80 EP - 92 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - isotopes KW - gas chromatograms KW - stable isotopes KW - molecular structure KW - bitumens KW - size distribution KW - organic compounds KW - hydrogen KW - diagenesis KW - carbon KW - sediments KW - sulfur KW - deuterium KW - geochemistry KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52722118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Influence+of+sulphur+cross-linking+on+the+molecular+size+distribution+of+sulphur-rich+macromolecules+in+bitumen&rft.au=Schouten%2C+Stefan%3BEglinton%2C+Timothy+I%3BSinninghe+Damste%2C+Jaap+S%3Bde+Leeuw%2C+Jan+W&rft.aulast=Schouten&rft.aufirst=Stefan&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 16 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - bitumens; carbon; deuterium; diagenesis; gas chromatograms; geochemistry; hydrogen; isotopes; molecular structure; organic compounds; organic materials; sediments; size distribution; stable isotopes; sulfur ER - TY - JOUR T1 - Kinetic controls on thermochemical sulfate reduction as a source of sedimentary H (sub 2) S AN - 52721289; 1997-038811 JF - ACS Symposium Series AU - Goldhaber, Martin B AU - Orr, Wilson L A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 412 EP - 425 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - mineral deposits, genesis KW - sulfate ion KW - natural gas KW - source rocks KW - rates KW - petroleum KW - hydrogen sulfide KW - aqueous solutions KW - temperature KW - mississippi valley-type deposits KW - sediments KW - thermochemical properties KW - reduction KW - sulfides KW - kinetics KW - geochemistry KW - 02C:Geochemistry of rocks, soils, and sediments KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52721289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Kinetic+controls+on+thermochemical+sulfate+reduction+as+a+source+of+sedimentary+H+%28sub+2%29+S&rft.au=Goldhaber%2C+Martin+B%3BOrr%2C+Wilson+L&rft.aulast=Goldhaber&rft.aufirst=Martin&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 28 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - aqueous solutions; geochemistry; hydrogen sulfide; kinetics; mineral deposits, genesis; mississippi valley-type deposits; natural gas; petroleum; rates; reduction; sediments; source rocks; sulfate ion; sulfides; temperature; thermochemical properties ER - TY - JOUR T1 - Organic geochemistry of sulfur-rich surface sediments of meromictic Lake Cadagno, Swiss Alps AN - 52721249; 1997-038792 JF - ACS Symposium Series AU - Putschew, Anke AU - Scholz-Boettcher, Barbara M AU - Rullkoetter, Juergen A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 59 EP - 79 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - early diagenesis KW - organic residues KW - Alps KW - aliphatic hydrocarbons KW - Europe KW - alkanes KW - Switzerland KW - Lake Cadagno KW - bitumens KW - Swiss Alps KW - organic compounds KW - biogenic processes KW - diagenesis KW - Central Europe KW - Ticino Switzerland KW - phytane KW - sediments KW - hydrocarbons KW - sulfur KW - anaerobic environment KW - organic sulfur KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52721249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Organic+geochemistry+of+sulfur-rich+surface+sediments+of+meromictic+Lake+Cadagno%2C+Swiss+Alps&rft.au=Putschew%2C+Anke%3BScholz-Boettcher%2C+Barbara+M%3BRullkoetter%2C+Juergen&rft.aulast=Putschew&rft.aufirst=Anke&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 42 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables, sect., sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; Alps; anaerobic environment; biogenic processes; bitumens; Central Europe; diagenesis; early diagenesis; Europe; hydrocarbons; Lake Cadagno; organic compounds; organic materials; organic residues; organic sulfur; phytane; sediments; sulfur; Swiss Alps; Switzerland; Ticino Switzerland ER - TY - JOUR T1 - Geochemical transformations of sedimentary sulfur; an introduction AN - 52721197; 1997-038789 JF - ACS Symposium Series AU - Vairavamurthy, Murthy A AU - Orr, Wilson L AU - Manowitz, Bernard A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 1 EP - 14 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - mining KW - pollutants KW - pollution KW - atmosphere KW - geochemical cycle KW - gases KW - catagenesis KW - sedimentary rocks KW - mining geology KW - diagenesis KW - sediments KW - sulfur KW - geochemistry KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52721197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Geochemical+transformations+of+sedimentary+sulfur%3B+an+introduction&rft.au=Vairavamurthy%2C+Murthy+A%3BOrr%2C+Wilson+L%3BManowitz%2C+Bernard&rft.aulast=Vairavamurthy&rft.aufirst=Murthy&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 80 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - atmosphere; catagenesis; diagenesis; gases; geochemical cycle; geochemistry; mining; mining geology; pollutants; pollution; sedimentary rocks; sediments; sulfur ER - TY - JOUR T1 - Devonian Nisku Sour Gas Play, Canada; a unique natural laboratory for study of thermochemical sulfate reduction AN - 52720793; 1997-038813 JF - ACS Symposium Series AU - Machel, H G AU - Krouse, H Roy AU - Riciputi, L R AU - Cole, D R A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 439 EP - 454 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - North America KW - sulfate ion KW - Paleozoic KW - petroleum KW - Alberta KW - oil and gas fields KW - spatial distribution KW - Devonian KW - Canada KW - Western Canada Basin KW - iron sulfides KW - diagenesis KW - Nisku Formation KW - Western Canada KW - thermochemical properties KW - reduction KW - sulfides KW - geochemistry KW - Upper Devonian KW - 29A:Economic geology, geology of energy sources KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52720793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Devonian+Nisku+Sour+Gas+Play%2C+Canada%3B+a+unique+natural+laboratory+for+study+of+thermochemical+sulfate+reduction&rft.au=Machel%2C+H+G%3BKrouse%2C+H+Roy%3BRiciputi%2C+L+R%3BCole%2C+D+R&rft.aulast=Machel&rft.aufirst=H&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 23 N1 - PubXState - DC N1 - Document feature - illus. incl. strat. cols., sect., sketch maps N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - Alberta; Canada; Devonian; diagenesis; geochemistry; iron sulfides; Nisku Formation; North America; oil and gas fields; Paleozoic; petroleum; reduction; spatial distribution; sulfate ion; sulfides; thermochemical properties; Upper Devonian; Western Canada; Western Canada Basin ER - TY - JOUR T1 - Reactions forming pyrite from precipitated amorphous ferrous sulfide AN - 52720753; 1997-038798 JF - ACS Symposium Series AU - Furukawa, Yoko AU - Barnes, H L A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 194 EP - 205 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - oxidation KW - authigenic minerals KW - iron KW - genesis KW - organic compounds KW - iron sulfides KW - precipitation KW - metals KW - marine environment KW - pyrite KW - sulfides KW - geochemistry KW - 02C:Geochemistry of rocks, soils, and sediments KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52720753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Reactions+forming+pyrite+from+precipitated+amorphous+ferrous+sulfide&rft.au=Furukawa%2C+Yoko%3BBarnes%2C+H+L&rft.aulast=Furukawa&rft.aufirst=Yoko&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 18 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - authigenic minerals; genesis; geochemistry; iron; iron sulfides; marine environment; metals; organic compounds; organic materials; oxidation; precipitation; pyrite; sulfides ER - TY - JOUR T1 - The distribution of free organic sulfur compounds in sediments from the Noerdlinger Ries, southern Germany AN - 52720748; 1997-038805 JF - ACS Symposium Series AU - Barakat, Assem O AU - Rullkoetter, Juergen A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 311 EP - 331 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - thiophenes KW - Bavaria Germany KW - gas chromatograms KW - Europe KW - bitumens KW - organic compounds KW - black shale KW - sedimentary rocks KW - thiolanes KW - Central Europe KW - sediments KW - Ries Crater KW - lacustrine environment KW - hydrocarbons KW - sulfur KW - Germany KW - geochemistry KW - clastic rocks KW - aromatic hydrocarbons KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52720748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=The+distribution+of+free+organic+sulfur+compounds+in+sediments+from+the+Noerdlinger+Ries%2C+southern+Germany&rft.au=Barakat%2C+Assem+O%3BRullkoetter%2C+Juergen&rft.aulast=Barakat&rft.aufirst=Assem&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 20 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables, strat. cols., sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - aromatic hydrocarbons; Bavaria Germany; bitumens; black shale; Central Europe; clastic rocks; Europe; gas chromatograms; geochemistry; Germany; hydrocarbons; lacustrine environment; organic compounds; organic materials; Ries Crater; sedimentary rocks; sediments; sulfur; thiolanes; thiophenes ER - TY - JOUR T1 - Transformations in organic sulfur speciation during maturation of Monterey Shale; constraints from laboratory experiments AN - 52720705; 1997-038796 JF - ACS Symposium Series AU - Nelson, Bryan C AU - Eglinton, Timothy I AU - Seewald, Jeffrey S AU - Vairavamurthy, Murthy A AU - Miknis, Francis P A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 138 EP - 166 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - source rocks KW - gas chromatograms KW - petroleum KW - NMR spectra KW - Cenozoic KW - Monterey Formation KW - sedimentary rocks KW - pyrolysis KW - thermal maturity KW - spectra KW - geochemistry KW - P-T conditions KW - organic materials KW - experimental studies KW - shale KW - X-ray spectra KW - Miocene KW - bitumens KW - Tertiary KW - organic compounds KW - Neogene KW - sulfur KW - kerogen KW - clastic rocks KW - 29A:Economic geology, geology of energy sources KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52720705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Transformations+in+organic+sulfur+speciation+during+maturation+of+Monterey+Shale%3B+constraints+from+laboratory+experiments&rft.au=Nelson%2C+Bryan+C%3BEglinton%2C+Timothy+I%3BSeewald%2C+Jeffrey+S%3BVairavamurthy%2C+Murthy+A%3BMiknis%2C+Francis+P&rft.aulast=Nelson&rft.aufirst=Bryan&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 29 N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - bitumens; Cenozoic; clastic rocks; experimental studies; gas chromatograms; geochemistry; kerogen; Miocene; Monterey Formation; Neogene; NMR spectra; organic compounds; organic materials; P-T conditions; petroleum; pyrolysis; sedimentary rocks; shale; source rocks; spectra; sulfur; Tertiary; thermal maturity; X-ray spectra ER - TY - JOUR T1 - Chemistry of iron sulfides in sedimentary environments AN - 52720668; 1997-038797 JF - ACS Symposium Series AU - Rickard, David AU - Schoonen, Martin A A AU - Luther, G W, III A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 168 EP - 193 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - genesis KW - marcasite KW - sedimentary rocks KW - chemical reactions KW - iron sulfides KW - oxidation KW - sediments KW - mechanism KW - pyrite KW - sulfides KW - geochemistry KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52720668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Chemistry+of+iron+sulfides+in+sedimentary+environments&rft.au=Rickard%2C+David%3BSchoonen%2C+Martin+A+A%3BLuther%2C+G+W%2C+III&rft.aulast=Rickard&rft.aufirst=David&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 172 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - chemical reactions; genesis; geochemistry; iron sulfides; marcasite; mechanism; oxidation; pyrite; sedimentary rocks; sediments; sulfides ER - TY - JOUR T1 - Temporal relationship of thiols to inorganic sulfur compounds in anoxic Chesapeake Bay sediment porewater AN - 52720383; 1997-038804 JF - ACS Symposium Series AU - MacCrehan, William AU - Shea, Damian A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 294 EP - 310 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - United States KW - Chesapeake Bay KW - oxidation KW - glutathione KW - hydrogen sulfide KW - cysteine KW - geochemical cycle KW - diagenesis KW - thiosulfate KW - thiols KW - sediments KW - sulfur KW - anaerobic environment KW - seasonal variations KW - estuarine environment KW - geochemistry KW - pore water KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52720383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Temporal+relationship+of+thiols+to+inorganic+sulfur+compounds+in+anoxic+Chesapeake+Bay+sediment+porewater&rft.au=MacCrehan%2C+William%3BShea%2C+Damian&rft.aulast=MacCrehan&rft.aufirst=William&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 59 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - anaerobic environment; Chesapeake Bay; cysteine; diagenesis; estuarine environment; geochemical cycle; geochemistry; glutathione; hydrogen sulfide; oxidation; pore water; seasonal variations; sediments; sulfur; thiols; thiosulfate; United States ER - TY - JOUR T1 - Digestion procedures for determining reduced sulfur species in bacterial cultures and in ancient and Recent sediments AN - 52720337; 1997-038801 JF - ACS Symposium Series AU - Allen, R E AU - Parkes, R J A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 243 EP - 257 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - thallophytes KW - methods KW - Plantae KW - polysulfides KW - authigenic minerals KW - metals KW - digestion KW - bacteria KW - sediments KW - sulfur KW - pyrite KW - reduction KW - sulfides KW - geochemistry KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52720337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Digestion+procedures+for+determining+reduced+sulfur+species+in+bacterial+cultures+and+in+ancient+and+Recent+sediments&rft.au=Allen%2C+R+E%3BParkes%2C+R+J&rft.aulast=Allen&rft.aufirst=R&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 31 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - authigenic minerals; bacteria; digestion; geochemistry; metals; methods; Plantae; polysulfides; pyrite; reduction; sediments; sulfides; sulfur; thallophytes ER - TY - JOUR T1 - Role of sulfur in the transformations of sedimentary organic matter; a mechanistic overview AN - 52720289; 1997-038790 JF - ACS Symposium Series AU - Aizenshtat, Zeev AU - Krein, Eitan B AU - Vairavamurthy, Murthy A AU - Goldstein, Ted P A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 16 EP - 37 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - organic compounds KW - catagenesis KW - sedimentary rocks KW - chemical reactions KW - thermal alteration KW - diagenesis KW - oxidation KW - sulfur KW - mechanism KW - geochemistry KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52720289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Role+of+sulfur+in+the+transformations+of+sedimentary+organic+matter%3B+a+mechanistic+overview&rft.au=Aizenshtat%2C+Zeev%3BKrein%2C+Eitan+B%3BVairavamurthy%2C+Murthy+A%3BGoldstein%2C+Ted+P&rft.aulast=Aizenshtat&rft.aufirst=Zeev&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 80 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - catagenesis; chemical reactions; diagenesis; geochemistry; mechanism; organic compounds; organic materials; oxidation; sedimentary rocks; sulfur; thermal alteration ER - TY - JOUR T1 - (super 35) S-radiolabeling to probe biogeochemical cycling of sulfur AN - 52718977; 1997-038807 JF - ACS Symposium Series AU - Fossing, Henrik A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 348 EP - 364 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - Stella II KW - isotopes KW - biochemistry KW - oxidation KW - data processing KW - rates KW - S-35 KW - measurement KW - geochemical cycle KW - models KW - computer programs KW - radioactive isotopes KW - tracers KW - thiosulfate KW - sediments KW - sulfur KW - reduction KW - geochemistry KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52718977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=%28super+35%29+S-radiolabeling+to+probe+biogeochemical+cycling+of+sulfur&rft.au=Fossing%2C+Henrik&rft.aulast=Fossing&rft.aufirst=Henrik&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 42 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - biochemistry; computer programs; data processing; geochemical cycle; geochemistry; isotopes; measurement; models; oxidation; radioactive isotopes; rates; reduction; S-35; sediments; Stella II; sulfur; thiosulfate; tracers ER - TY - JOUR T1 - Oxidation of hydrogen sulfide by Mn(IV) and Fe(III) (hydr)oxides in seawater AN - 52718948; 1997-038802 JF - ACS Symposium Series AU - Yao, Wensheng AU - Millero, Frank H A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 260 EP - 279 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - experimental studies KW - sea water KW - oxidation KW - rates KW - hydrogen sulfide KW - manganese KW - hydrochemistry KW - iron KW - temperature KW - hydroxides KW - ferric iron KW - organic compounds KW - ligands KW - metals KW - oxides KW - geochemistry KW - pH KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52718948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Oxidation+of+hydrogen+sulfide+by+Mn%28IV%29+and+Fe%28III%29+%28hydr%29oxides+in+seawater&rft.au=Yao%2C+Wensheng%3BMillero%2C+Frank+H&rft.aulast=Yao&rft.aufirst=Wensheng&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 65 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - experimental studies; ferric iron; geochemistry; hydrochemistry; hydrogen sulfide; hydroxides; iron; ligands; manganese; metals; organic compounds; organic materials; oxidation; oxides; pH; rates; sea water; temperature ER - TY - JOUR T1 - 208th national meeting of the American Chemical Society AN - 52717484; 1997-038788 JF - ACS Symposium Series A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 467 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - organic compounds KW - sedimentary rocks KW - symposia KW - source rocks KW - sediments KW - sulfur KW - petroleum KW - geochemistry KW - 29A:Economic geology, geology of energy sources KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52717484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=ACS+Symposium+Series&rft.atitle=208th+national+meeting+of+the+American+Chemical+Society&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Document feature - illus. N1 - SuppNotes - Individual papers are cited separately N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - geochemistry; organic compounds; organic materials; petroleum; sedimentary rocks; sediments; source rocks; sulfur; symposia ER - TY - JOUR T1 - Controls on the origin and distribution of elemental sulfur, H (sub 2) S and CO (sub 2) in Paleozoic hydrocarbon reservoirs in Western Canada AN - 52715811; 1997-038812 JF - ACS Symposium Series AU - Hutcheon, Ian AU - Krouse, H Roy AU - Abercrombie, Hugh J A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 426 EP - 438 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - North America KW - isotopes KW - Paleozoic KW - natural gas KW - oxidation KW - connate waters KW - petroleum KW - hydrogen sulfide KW - stable isotopes KW - reservoir rocks KW - carbon dioxide KW - Canada KW - Western Canada Basin KW - carbon KW - sulfur KW - Western Canada KW - C-13 KW - thermochemical properties KW - reduction KW - geochemistry KW - pore water KW - 29A:Economic geology, geology of energy sources KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52715811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Controls+on+the+origin+and+distribution+of+elemental+sulfur%2C+H+%28sub+2%29+S+and+CO+%28sub+2%29+in+Paleozoic+hydrocarbon+reservoirs+in+Western+Canada&rft.au=Hutcheon%2C+Ian%3BKrouse%2C+H+Roy%3BAbercrombie%2C+Hugh+J&rft.aulast=Hutcheon&rft.aufirst=Ian&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 31 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - C-13; Canada; carbon; carbon dioxide; connate waters; geochemistry; hydrogen sulfide; isotopes; natural gas; North America; oxidation; Paleozoic; petroleum; pore water; reduction; reservoir rocks; stable isotopes; sulfur; thermochemical properties; Western Canada; Western Canada Basin ER - TY - JOUR T1 - Sulfate incorporation into sedimentary carbonates AN - 52715785; 1997-038806 JF - ACS Symposium Series AU - Staudt, Wilfried J AU - Schoonen, Martin A A A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 332 EP - 345 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - sulfate ion KW - carbonate platforms KW - aragonite KW - recrystallization KW - burial KW - geochemical cycle KW - calcite KW - dolomite KW - marine environment KW - diagenesis KW - shelf environment KW - sediments KW - sulfur KW - calcium carbonate KW - North Atlantic KW - geochemistry KW - Caribbean Sea KW - carbonates KW - Atlantic Ocean KW - 06A:Sedimentary petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52715785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Sulfate+incorporation+into+sedimentary+carbonates&rft.au=Staudt%2C+Wilfried+J%3BSchoonen%2C+Martin+A+A&rft.aulast=Staudt&rft.aufirst=Wilfried&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 43 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - aragonite; Atlantic Ocean; burial; calcite; calcium carbonate; carbonate platforms; carbonates; Caribbean Sea; diagenesis; dolomite; geochemical cycle; geochemistry; marine environment; North Atlantic; recrystallization; sediments; shelf environment; sulfate ion; sulfur ER - TY - JOUR T1 - Stable sulfur isotopic compositions of chromium-reducible sulfur in lake sediments AN - 52715716; 1997-038810 JF - ACS Symposium Series AU - Fry, Brian AU - Giblin, Anne AU - Dornblaser, Mark AU - Peterson, Bruce A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 397 EP - 410 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - United States KW - thallophytes KW - Plantae KW - sulfates KW - isotopes KW - isotope ratios KW - stable isotopes KW - biogenic processes KW - S-34/S-32 KW - Canada KW - metals KW - carbon KW - bacteria KW - sediments KW - Nova Scotia KW - lacustrine environment KW - sulfur KW - reduction KW - Maritime Provinces KW - Eastern Canada KW - geochemistry KW - fractionation KW - chromium KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52715716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Stable+sulfur+isotopic+compositions+of+chromium-reducible+sulfur+in+lake+sediments&rft.au=Fry%2C+Brian%3BGiblin%2C+Anne%3BDornblaser%2C+Mark%3BPeterson%2C+Bruce&rft.aulast=Fry&rft.aufirst=Brian&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 36 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - bacteria; biogenic processes; Canada; carbon; chromium; Eastern Canada; fractionation; geochemistry; isotope ratios; isotopes; lacustrine environment; Maritime Provinces; metals; Nova Scotia; Plantae; reduction; S-34/S-32; sediments; stable isotopes; sulfates; sulfur; thallophytes; United States ER - TY - JOUR T1 - Characterization of a transient +2 sulfur oxidation state intermediate from the oxidation of aqueous sulfide AN - 52715668; 1997-038803 JF - ACS Symposium Series AU - Vairavamurthy, Murthy A AU - Zhou, Weiqing A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 280 EP - 292 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - experimental studies KW - sulfate ion KW - solutions KW - oxidation KW - hydrogen sulfide KW - X-ray spectra KW - infrared spectra KW - geochemical cycle KW - XANES spectra KW - Fourier analysis KW - sediments KW - sulfur KW - spectra KW - sulfides KW - geochemistry KW - aquatic environment KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52715668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Characterization+of+a+transient+%2B2+sulfur+oxidation+state+intermediate+from+the+oxidation+of+aqueous+sulfide&rft.au=Vairavamurthy%2C+Murthy+A%3BZhou%2C+Weiqing&rft.aulast=Vairavamurthy&rft.aufirst=Murthy&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 25 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - aquatic environment; experimental studies; Fourier analysis; geochemical cycle; geochemistry; hydrogen sulfide; infrared spectra; oxidation; sediments; solutions; spectra; sulfate ion; sulfides; sulfur; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Proposed thermal pathways for sulfur transformations in organic macromolecules; laboratory simulation experiments AN - 52715617; 1997-038795 JF - ACS Symposium Series AU - Krein, Eitan B AU - Aizenshtat, Zeev A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 110 EP - 137 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - experimental studies KW - thermal alteration KW - aliphatic hydrocarbons KW - simulation KW - temperature KW - aliphatic polysulfide polymers KW - oligomers KW - organic compounds KW - catagenesis KW - sedimentary rocks KW - diagenesis KW - alkenes KW - sediments KW - hydrocarbons KW - sulfur KW - polymers KW - geochemistry KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52715617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Proposed+thermal+pathways+for+sulfur+transformations+in+organic+macromolecules%3B+laboratory+simulation+experiments&rft.au=Krein%2C+Eitan+B%3BAizenshtat%2C+Zeev&rft.aulast=Krein&rft.aufirst=Eitan&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 27 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - SuppNotes - Includes an appendix N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; aliphatic polysulfide polymers; alkenes; catagenesis; diagenesis; experimental studies; geochemistry; hydrocarbons; oligomers; organic compounds; organic materials; polymers; sedimentary rocks; sediments; simulation; sulfur; temperature; thermal alteration ER - TY - JOUR T1 - Microbial assimilation and dissimilation of sulfonate sulfur AN - 52714995; 1997-038808 JF - ACS Symposium Series AU - Seitz, A P AU - Leadbetter, E R A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 365 EP - 376 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - thallophytes KW - sulfonates KW - Plantae KW - organic compounds KW - biogenic processes KW - biochemistry KW - bacteria KW - sediments KW - sulfur KW - geochemistry KW - geochemical cycle KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52714995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Microbial+assimilation+and+dissimilation+of+sulfonate+sulfur&rft.au=Seitz%2C+A+P%3BLeadbetter%2C+E+R&rft.aulast=Seitz&rft.aufirst=A&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 64 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - bacteria; biochemistry; biogenic processes; geochemical cycle; geochemistry; organic compounds; Plantae; sediments; sulfonates; sulfur; thallophytes ER - TY - JOUR T1 - Alkanoic subunits in sulfur-rich geomacromolecules; information from stepwise chemical degradation and compound-specific isotopic analysis AN - 52714925; 1997-038794 JF - ACS Symposium Series AU - Hefter, J AU - Hauke, V AU - Richnow, H H AU - Michaelis, W A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 93 EP - 109 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - isotopes KW - isotope ratios KW - C-13/C-12 KW - gas chromatograms KW - aliphatic hydrocarbons KW - mass spectra KW - stable isotopes KW - molecular structure KW - organic compounds KW - carbon KW - sediments KW - hydrocarbons KW - sulfur KW - spectra KW - kerogen KW - geochemistry KW - aromatic hydrocarbons KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52714925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Alkanoic+subunits+in+sulfur-rich+geomacromolecules%3B+information+from+stepwise+chemical+degradation+and+compound-specific+isotopic+analysis&rft.au=Hefter%2C+J%3BHauke%2C+V%3BRichnow%2C+H+H%3BMichaelis%2C+W&rft.aulast=Hefter&rft.aufirst=J&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 35 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; aromatic hydrocarbons; C-13/C-12; carbon; gas chromatograms; geochemistry; hydrocarbons; isotope ratios; isotopes; kerogen; mass spectra; molecular structure; organic compounds; organic materials; sediments; spectra; stable isotopes; sulfur ER - TY - JOUR T1 - Isotopic evidence for the origin of organic sulfur and elemental sulfur in marine sediments AN - 52714865; 1997-038809 JF - ACS Symposium Series AU - Anderson, Thomas F AU - Pratt, Lisa M A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 378 EP - 396 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - sea water KW - isotopes KW - oxidation KW - S-34 KW - hydrogen sulfide KW - stable isotopes KW - genesis KW - organic compounds KW - marine sediments KW - diagenesis KW - sediments KW - sulfur KW - pyrite KW - sulfides KW - geochemistry KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52714865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Isotopic+evidence+for+the+origin+of+organic+sulfur+and+elemental+sulfur+in+marine+sediments&rft.au=Anderson%2C+Thomas+F%3BPratt%2C+Lisa+M&rft.aulast=Anderson&rft.aufirst=Thomas&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 73 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - diagenesis; genesis; geochemistry; hydrogen sulfide; isotopes; marine sediments; organic compounds; organic materials; oxidation; pyrite; S-34; sea water; sediments; stable isotopes; sulfides; sulfur ER - TY - JOUR T1 - Environmental controls on iron sulfide mineral formation in a coastal plain estuary AN - 52714510; 1997-038800 JF - ACS Symposium Series AU - Cornwell, Jeffrey C AU - Sampou, Peter A A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 224 EP - 242 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - United States KW - organic materials KW - Chesapeake Bay KW - isotopes KW - isotope ratios KW - oxidation KW - salinity KW - hydrochemistry KW - coastal plains KW - stable isotopes KW - genesis KW - organic compounds KW - S-34/S-32 KW - iron sulfides KW - sediments KW - sulfur KW - estuarine environment KW - sulfides KW - geochemistry KW - pore water KW - Atlantic Coastal Plain KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52714510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Environmental+controls+on+iron+sulfide+mineral+formation+in+a+coastal+plain+estuary&rft.au=Cornwell%2C+Jeffrey+C%3BSampou%2C+Peter+A&rft.aulast=Cornwell&rft.aufirst=Jeffrey&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 67 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - Atlantic Coastal Plain; Chesapeake Bay; coastal plains; estuarine environment; genesis; geochemistry; hydrochemistry; iron sulfides; isotope ratios; isotopes; organic compounds; organic materials; oxidation; pore water; S-34/S-32; salinity; sediments; stable isotopes; sulfides; sulfur; United States ER - TY - JOUR T1 - Laboratory simulation of pyrite formation in anoxic sediments AN - 52714477; 1997-038799 JF - ACS Symposium Series AU - Wang, Qiwei AU - Morse, John W A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 206 EP - 223 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - experimental studies KW - goethite KW - pyritization KW - authigenic minerals KW - simulation KW - metasomatism KW - genesis KW - marine sediments KW - mackinawite KW - iron sulfides KW - precipitation KW - greigite KW - sediments KW - oxides KW - anaerobic environment KW - pyrite KW - sulfides KW - geochemistry KW - pH KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52714477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Laboratory+simulation+of+pyrite+formation+in+anoxic+sediments&rft.au=Wang%2C+Qiwei%3BMorse%2C+John+W&rft.aulast=Wang&rft.aufirst=Qiwei&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 37 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 plates, 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - anaerobic environment; authigenic minerals; experimental studies; genesis; geochemistry; goethite; greigite; iron sulfides; mackinawite; marine sediments; metasomatism; oxides; pH; precipitation; pyrite; pyritization; sediments; simulation; sulfides ER - TY - JOUR T1 - Sulfur transformations in early diagenetic sediments from the Bay of Concepcion, off Chile AN - 52710041; 1997-038791 JF - ACS Symposium Series AU - Vairavamurthy, Murthy A AU - Wang, Shengke AU - Khandelwal, Bandana AU - Manowitz, Bernard AU - Ferdelman, Timothy AU - Fossing, Henrik A2 - Vairavamurthy, Murthy A. A2 - Schoonen, Martin A. A. A2 - Eglinton, Timothy I. A2 - Luther, George W., III A2 - Manowitz, Bernard Y1 - 1994 PY - 1994 DA - 1994 SP - 38 EP - 58 PB - American Chemical Society, Washington, DC VL - 612 SN - 0097-6156, 0097-6156 KW - organic materials KW - Biobio Chile KW - offshore KW - Chile KW - X-ray spectra KW - XANES spectra KW - South America KW - organic compounds KW - biogenic processes KW - diagenesis KW - sediments KW - sulfur KW - pyrite KW - spectra KW - reduction KW - Bay of Concepcion KW - sulfides KW - geochemistry KW - chemical fractionation KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52710041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Sulfur+transformations+in+early+diagenetic+sediments+from+the+Bay+of+Concepcion%2C+off+Chile&rft.au=Vairavamurthy%2C+Murthy+A%3BWang%2C+Shengke%3BKhandelwal%2C+Bandana%3BManowitz%2C+Bernard%3BFerdelman%2C+Timothy%3BFossing%2C+Henrik&rft.aulast=Vairavamurthy&rft.aufirst=Murthy&rft.date=1994-01-01&rft.volume=612&rft.issue=&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 208th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 54 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - Bay of Concepcion; Biobio Chile; biogenic processes; chemical fractionation; Chile; diagenesis; geochemistry; offshore; organic compounds; organic materials; pyrite; reduction; sediments; South America; spectra; sulfides; sulfur; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Potential applications of synchrotron computed microtomography to soil science AN - 52129481; 2002-019001 JF - SSSA Special Publication AU - Spanne, P AU - Jones, K W AU - Prunty, Lyle AU - Anderson, Stephen H A2 - Anderson, Stephen H. A2 - Hopmans, Jan W. Y1 - 1994 PY - 1994 DA - 1994 SP - 43 EP - 57 PB - Soil Science Society of America, Madison, WI VL - 36 SN - 1063-2565, 1063-2565 KW - tomography KW - synchrotron radiation KW - soils KW - absorption KW - sample preparation KW - imagery KW - X-ray data KW - hydraulics KW - capillary pressure KW - applications KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52129481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SSSA+Special+Publication&rft.atitle=Potential+applications+of+synchrotron+computed+microtomography+to+soil+science&rft.au=Spanne%2C+P%3BJones%2C+K+W%3BPrunty%2C+Lyle%3BAnderson%2C+Stephen+H&rft.aulast=Spanne&rft.aufirst=P&rft.date=1994-01-01&rft.volume=36&rft.issue=&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=SSSA+Special+Publication&rft.issn=10632565&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Soil Science Society of America annual meeting symposium on Tomography for measurement of soil physical properties and processes N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 15 N1 - PubXState - WI N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absorption; applications; capillary pressure; hydraulics; imagery; sample preparation; soils; synchrotron radiation; tomography; X-ray data ER - TY - JOUR T1 - Determination of hydrogen sulfide oxidation products by sulfur K-edge X-ray absorption near-edge structure spectroscopy AN - 51721194; 2005-025202 JF - ACS Symposium Series AU - Vairavamurthy, Appathural AU - Manowitz, Bernard AU - Zhou, Weiqing AU - Jeon, Yongseog A2 - Alpers, Charles N. A2 - Blowes, David W. Y1 - 1994 PY - 1994 DA - 1994 SP - 412 EP - 430 PB - American Chemical Society, Washington, DC VL - 550 SN - 0097-6156, 0097-6156 KW - water KW - methods KW - thiosulfates KW - X-ray absorption near-edge spectroscopy KW - sulfates KW - oxidation KW - hydrogen sulfide KW - crystal structure KW - qualitative analysis KW - X-ray spectra KW - XANES spectra KW - quantitative analysis KW - X-ray spectroscopy KW - X-ray analysis KW - spectra KW - sulfides KW - spectroscopy KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51721194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Symposium+Series&rft.atitle=Determination+of+hydrogen+sulfide+oxidation+products+by+sulfur+K-edge+X-ray+absorption+near-edge+structure+spectroscopy&rft.au=Vairavamurthy%2C+Appathural%3BManowitz%2C+Bernard%3BZhou%2C+Weiqing%3BJeon%2C+Yongseog&rft.aulast=Vairavamurthy&rft.aufirst=Appathural&rft.date=1994-01-01&rft.volume=550&rft.issue=&rft.spage=412&rft.isbn=0841227721&rft.btitle=&rft.title=ACS+Symposium+Series&rft.issn=00976156&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 204th national meeting of the American Chemical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 42 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ACSMC8 N1 - SubjectsTermNotLitGenreText - crystal structure; hydrogen sulfide; methods; oxidation; qualitative analysis; quantitative analysis; spectra; spectroscopy; sulfates; sulfides; thiosulfates; water; X-ray absorption near-edge spectroscopy; X-ray analysis; X-ray spectra; X-ray spectroscopy; XANES spectra ER - TY - JOUR T1 - Pilot study risk assessment for selected problems at three U.S. Department of Energy facilities AN - 51534352; 2006-081814 JF - Environment International AU - Hamilton, L D AU - Holtzman, S AU - Meinhold, A F AU - Morris, S C AU - Pardi, R AU - Rowe, M D AU - Sun, C AU - Anspaugh, L R AU - Bogen, K T AU - Daniels, J I AU - Layton, D W AU - McKone, T E AU - Straume, T AU - Andricevic, R AU - Jacobson, R L A2 - Harley, Naomi H. Y1 - 1994 PY - 1994 DA - 1994 SP - 585 EP - 604 PB - Pergamon, New York-Oxford VL - 20 IS - 5 SN - 0160-4120, 0160-4120 KW - United States KW - South Carolina KW - isotopes KW - Fernald Nuclear Facility KW - alkali metals KW - pollution KW - tritium KW - environmental analysis KW - radioactive waste KW - human ecology KW - Nevada Test Site KW - radioactive isotopes KW - Cs-137 KW - cesium KW - metals KW - hydrogen KW - risk assessment KW - waste disposal KW - Savannah River Site KW - Nevada KW - Ohio KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51534352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+International&rft.atitle=Pilot+study+risk+assessment+for+selected+problems+at+three+U.S.+Department+of+Energy+facilities&rft.au=Hamilton%2C+L+D%3BHoltzman%2C+S%3BMeinhold%2C+A+F%3BMorris%2C+S+C%3BPardi%2C+R%3BRowe%2C+M+D%3BSun%2C+C%3BAnspaugh%2C+L+R%3BBogen%2C+K+T%3BDaniels%2C+J+I%3BLayton%2C+D+W%3BMcKone%2C+T+E%3BStraume%2C+T%3BAndricevic%2C+R%3BJacobson%2C+R+L&rft.aulast=Hamilton&rft.aufirst=L&rft.date=1994-01-01&rft.volume=20&rft.issue=5&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Environment+International&rft.issn=01604120&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/01604120 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 40 N1 - Document feature - illus. incl. 2 tables, sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - alkali metals; cesium; Cs-137; environmental analysis; Fernald Nuclear Facility; human ecology; hydrogen; isotopes; metals; Nevada; Nevada Test Site; Ohio; pollution; radioactive isotopes; radioactive waste; risk assessment; Savannah River Site; South Carolina; tritium; United States; waste disposal ER - TY - JOUR T1 - (super 210) Pb balance and implications for particle transport on the continental shelf, U. S. Middle Atlantic Bight AN - 51506533; 2007-008870 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Bacon, M P AU - Belastock, R A AU - Bothner, M H Y1 - 1994 PY - 1994 DA - 1994 SP - 511 EP - 535 PB - Pergamon, Oxford VL - 41 IS - 2-3 SN - 0967-0645, 0967-0645 KW - United States KW - SEEP-II Program KW - sediment transport KW - isotopes KW - sedimentation KW - lead KW - suspended materials KW - marine sedimentation KW - radioactive isotopes KW - metals KW - particulate materials KW - continental shelf KW - Middle Atlantic Bight KW - Pb-210 KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51506533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=%28super+210%29+Pb+balance+and+implications+for+particle+transport+on+the+continental+shelf%2C+U.+S.+Middle+Atlantic+Bight&rft.au=Bacon%2C+M+P%3BBelastock%2C+R+A%3BBothner%2C+M+H&rft.aulast=Bacon&rft.aufirst=M&rft.date=1994-01-01&rft.volume=41&rft.issue=2-3&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 50 N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - continental shelf; isotopes; lead; marine sedimentation; metals; Middle Atlantic Bight; particulate materials; Pb-210; radioactive isotopes; sediment transport; sedimentation; SEEP-II Program; suspended materials; United States ER - TY - JOUR T1 - The Shelf Edge Exchange Processes Experiment, SEEP-II; an introduction to hypotheses, results and conclusions AN - 51506493; 2007-008867 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Biscaye, Pierre E AU - Flagg, Charles N AU - Falkowski, Paul G Y1 - 1994 PY - 1994 DA - 1994 SP - 231 EP - 252 PB - Pergamon, Oxford VL - 41 IS - 2-3 SN - 0967-0645, 0967-0645 KW - United States KW - continental slope KW - SEEP-II Program KW - sedimentation KW - marine geology KW - marine sedimentation KW - organic compounds KW - biogenic processes KW - carbon KW - particulate materials KW - continental shelf KW - organic carbon KW - Middle Atlantic Bight KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51506493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=The+Shelf+Edge+Exchange+Processes+Experiment%2C+SEEP-II%3B+an+introduction+to+hypotheses%2C+results+and+conclusions&rft.au=Biscaye%2C+Pierre+E%3BFlagg%2C+Charles+N%3BFalkowski%2C+Paul+G&rft.aulast=Biscaye&rft.aufirst=Pierre&rft.date=1994-01-01&rft.volume=41&rft.issue=2-3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 50 N1 - Document feature - illus. incl. 1 table, geol. sketch maps N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - biogenic processes; carbon; continental shelf; continental slope; marine geology; marine sedimentation; Middle Atlantic Bight; organic carbon; organic compounds; particulate materials; sedimentation; SEEP-II Program; United States ER - TY - JOUR T1 - Anomalous boundary scavenging in the Middle Atlantic Bight; evidence from (super 230) Th, (super 231) Pa, (super 10) Be and (super 210) Pb AN - 51505017; 2007-008871 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Anderson, R F AU - Fleisher, M Q AU - Biscaye, Pierre E AU - Kumar, N AU - Dittrich, B AU - Kubik, P AU - Suter, M Y1 - 1994 PY - 1994 DA - 1994 SP - 537 EP - 561 PB - Pergamon, Oxford VL - 41 IS - 2-3 SN - 0967-0645, 0967-0645 KW - United States KW - Th-230 KW - SEEP-II Program KW - isotopes KW - scavenging KW - lead KW - marine sedimentation KW - marine sediments KW - radioactive isotopes KW - sediments KW - protactinium KW - Pa-231 KW - Middle Atlantic Bight KW - geochemistry KW - alkaline earth metals KW - continental margin KW - Be-10 KW - isotope ratios KW - sedimentation KW - boundary conditions KW - metals KW - thorium KW - uranium KW - actinides KW - beryllium KW - Pb-210 KW - 02D:Isotope geochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51505017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Anomalous+boundary+scavenging+in+the+Middle+Atlantic+Bight%3B+evidence+from+%28super+230%29+Th%2C+%28super+231%29+Pa%2C+%28super+10%29+Be+and+%28super+210%29+Pb&rft.au=Anderson%2C+R+F%3BFleisher%2C+M+Q%3BBiscaye%2C+Pierre+E%3BKumar%2C+N%3BDittrich%2C+B%3BKubik%2C+P%3BSuter%2C+M&rft.aulast=Anderson&rft.aufirst=R&rft.date=1994-01-01&rft.volume=41&rft.issue=2-3&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 52 N1 - Document feature - illus. incl. 5 tables, geol. sketch map N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - actinides; alkaline earth metals; Be-10; beryllium; boundary conditions; continental margin; geochemistry; isotope ratios; isotopes; lead; marine sedimentation; marine sediments; metals; Middle Atlantic Bight; Pa-231; Pb-210; protactinium; radioactive isotopes; scavenging; sedimentation; sediments; SEEP-II Program; Th-230; thorium; United States; uranium ER - TY - JOUR T1 - Shelf edge exchange processes in the southern Middle Atlantic Bight; SEEP-II AN - 51503920; 2007-008866 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography Y1 - 1994 PY - 1994 DA - 1994 SP - 703 PB - Pergamon, Oxford VL - 41 IS - 2-3 SN - 0967-0645, 0967-0645 KW - United States KW - processes KW - SEEP-II Program KW - marine geology KW - continental shelf KW - Middle Atlantic Bight KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51503920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1994-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Shelf+edge+exchange+processes+in+the+southern+Middle+Atlantic+Bight%3B+SEEP-II&rft.title=Shelf+edge+exchange+processes+in+the+southern+Middle+Atlantic+Bight%3B+SEEP-II&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Document feature - illus. N1 - SuppNotes - Individual papers within scope are cited separately N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - continental shelf; marine geology; Middle Atlantic Bight; processes; SEEP-II Program; United States ER - TY - JOUR T1 - Sediment resuspension over the continental shelf east of the Delmarva Peninsula AN - 51503886; 2007-008868 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Churchill, J H AU - Wirick, C D AU - Flagg, Charles N AU - Pietrafesa, L J Y1 - 1994 PY - 1994 DA - 1994 SP - 341 EP - 363 PB - Pergamon, Oxford VL - 41 IS - 2-3 SN - 0967-0645, 0967-0645 KW - United States KW - currents KW - Northwest Atlantic KW - SEEP-II Program KW - fines KW - sedimentation KW - suspension KW - suspended materials KW - marine sedimentation KW - organic compounds KW - outer shelf KW - carbon KW - continental shelf KW - organic carbon KW - North Atlantic KW - Middle Atlantic Bight KW - Delmarva Peninsula KW - Atlantic Ocean KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51503886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Sediment+resuspension+over+the+continental+shelf+east+of+the+Delmarva+Peninsula&rft.au=Churchill%2C+J+H%3BWirick%2C+C+D%3BFlagg%2C+Charles+N%3BPietrafesa%2C+L+J&rft.aulast=Churchill&rft.aufirst=J&rft.date=1994-01-01&rft.volume=41&rft.issue=2-3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 49 N1 - Document feature - illus. incl. block diag., 1 table, geol. sketch map N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; carbon; continental shelf; currents; Delmarva Peninsula; fines; marine sedimentation; Middle Atlantic Bight; North Atlantic; Northwest Atlantic; organic carbon; organic compounds; outer shelf; sedimentation; SEEP-II Program; suspended materials; suspension; United States ER - TY - JOUR T1 - Deep-sea floor respiration as an indication of lateral input of biogenic detritus from continental margins AN - 51503605; 2007-008872 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Rowe, G T AU - Boland, G S AU - Phoel, W C AU - Anderson, R F AU - Biscaye, Pierre E Y1 - 1994 PY - 1994 DA - 1994 SP - 657 EP - 668 PB - Pergamon, Oxford VL - 41 IS - 2-3 SN - 0967-0645, 0967-0645 KW - respiration KW - Northwest Atlantic KW - sediment oxygen demand KW - continental margin KW - oxygen KW - SEEP-II Program KW - deep-sea environment KW - detritus KW - organic compounds KW - marine sediments KW - biogenic processes KW - marine environment KW - sediments KW - ocean floors KW - North Atlantic KW - Atlantic Ocean KW - sediment traps KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51503605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Deep-sea+floor+respiration+as+an+indication+of+lateral+input+of+biogenic+detritus+from+continental+margins&rft.au=Rowe%2C+G+T%3BBoland%2C+G+S%3BPhoel%2C+W+C%3BAnderson%2C+R+F%3BBiscaye%2C+Pierre+E&rft.aulast=Rowe&rft.aufirst=G&rft.date=1994-01-01&rft.volume=41&rft.issue=2-3&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 39 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - Atlantic Ocean; biogenic processes; continental margin; deep-sea environment; detritus; marine environment; marine sediments; North Atlantic; Northwest Atlantic; ocean floors; organic compounds; oxygen; respiration; sediment oxygen demand; sediment traps; sediments; SEEP-II Program ER - TY - JOUR T1 - Fluxes of particular matter on the slope of the southern Middle Atlantic Bight; SEEP-II AN - 51503565; 2007-008869 JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Biscaye, Pierre E AU - Anderson, Robert F Y1 - 1994 PY - 1994 DA - 1994 SP - 459 EP - 509 PB - Pergamon, Oxford VL - 41 IS - 2-3 SN - 0967-0645, 0967-0645 KW - United States KW - solute transport KW - silicates KW - silica minerals KW - SEEP-II Program KW - isotopes KW - Th-234 KW - lead KW - nitrogen KW - marine sediments KW - radioactive isotopes KW - carbon KW - sediments KW - framework silicates KW - calcium carbonate KW - particulate materials KW - organic carbon KW - Middle Atlantic Bight KW - Delmarva Peninsula KW - sediment traps KW - opal KW - metals KW - Norfolk Canyon KW - thorium KW - Washington Canyon KW - continental shelf KW - actinides KW - Pb-210 KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51503565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Fluxes+of+particular+matter+on+the+slope+of+the+southern+Middle+Atlantic+Bight%3B+SEEP-II&rft.au=Biscaye%2C+Pierre+E%3BAnderson%2C+Robert+F&rft.aulast=Biscaye&rft.aufirst=Pierre&rft.date=1994-01-01&rft.volume=41&rft.issue=2-3&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 36 N1 - Last updated - 2013-06-13 N1 - SubjectsTermNotLitGenreText - actinides; calcium carbonate; carbon; continental shelf; Delmarva Peninsula; framework silicates; isotopes; lead; marine sediments; metals; Middle Atlantic Bight; nitrogen; Norfolk Canyon; opal; organic carbon; particulate materials; Pb-210; radioactive isotopes; sediment traps; sediments; SEEP-II Program; silica minerals; silicates; solute transport; Th-234; thorium; United States; Washington Canyon ER - TY - JOUR T1 - High temperature single crystal X-ray and neutron diffraction studies of the ortho-proto phase transition in enstatite, Mg (sub 2) Si (sub 2) O (sub 6) AN - 51325603; 1995-027797 JF - Abstracts with Programs - Geological Society of America AU - Ghose, Subrata AU - Yang, Hexiong AU - Haga, Nobuhiko AU - McMullan, Richard K AU - Anonymous Y1 - 1994 PY - 1994 DA - 1994 SP - 166 PB - Geological Society of America (GSA), Boulder, CO VL - 26 IS - 7 SN - 0016-7592, 0016-7592 KW - silicates KW - anions KW - refinement KW - X-ray diffraction data KW - mechanism KW - phase transitions KW - crystal structure KW - temperature KW - protoenstatite KW - pyroxene group KW - single-crystal method KW - neutron diffraction data KW - cations KW - orthopyroxene KW - high temperature KW - enstatite KW - chain silicates KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51325603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=High+temperature+single+crystal+X-ray+and+neutron+diffraction+studies+of+the+ortho-proto+phase+transition+in+enstatite%2C+Mg+%28sub+2%29+Si+%28sub+2%29+O+%28sub+6%29&rft.au=Ghose%2C+Subrata%3BYang%2C+Hexiong%3BHaga%2C+Nobuhiko%3BMcMullan%2C+Richard+K%3BAnonymous&rft.aulast=Ghose&rft.aufirst=Subrata&rft.date=1994-01-01&rft.volume=26&rft.issue=7&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1994 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - anions; cations; chain silicates; crystal structure; enstatite; high temperature; mechanism; neutron diffraction data; orthopyroxene; phase transitions; protoenstatite; pyroxene group; refinement; silicates; single-crystal method; temperature; X-ray diffraction data ER - TY - JOUR T1 - Cleat-filling calcite in Illinois Basin coals; trace-element evidence for meteoric fluid migration in a coal basin AN - 50269884; 1994-015754 JF - Journal of Geology AU - Kolker, Allan AU - Chou, Chen-Liu Y1 - 1994/01// PY - 1994 DA - January 1994 SP - 111 EP - 116 PB - University of Chicago Press, Chicago, IL VL - 102 IS - 1 SN - 0022-1376, 0022-1376 KW - United States KW - calcium KW - Herrin Coal Member KW - Springfield Coal Member KW - organic residues KW - Pennsylvanian KW - cleats KW - manganese KW - iron KW - bituminous coal KW - ground water KW - partitioning KW - sedimentary rocks KW - coal KW - movement KW - trace elements KW - meteoric water KW - Illinois Basin KW - alkaline earth metals KW - Paleozoic KW - Carboniferous KW - cathodoluminescence KW - two-dimensional models KW - calcite KW - Colchester Coal Member KW - precipitation KW - metals KW - carbonates KW - strontium KW - 06B:Petrology of coal KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50269884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geology&rft.atitle=Cleat-filling+calcite+in+Illinois+Basin+coals%3B+trace-element+evidence+for+meteoric+fluid+migration+in+a+coal+basin&rft.au=Kolker%2C+Allan%3BChou%2C+Chen-Liu&rft.aulast=Kolker&rft.aufirst=Allan&rft.date=1994-01-01&rft.volume=102&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geology&rft.issn=00221376&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - Number of references - 21 N1 - PubXState - IL N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - JGEOAZ N1 - SubjectsTermNotLitGenreText - alkaline earth metals; bituminous coal; calcite; calcium; carbonates; Carboniferous; cathodoluminescence; cleats; coal; Colchester Coal Member; ground water; Herrin Coal Member; Illinois Basin; iron; manganese; metals; meteoric water; movement; organic residues; Paleozoic; partitioning; Pennsylvanian; precipitation; sedimentary rocks; Springfield Coal Member; strontium; trace elements; two-dimensional models; United States ER - TY - JOUR T1 - Radiocarbon and uranium-series dating of the Plitvice lakes travertines AN - 50117404; 1995-057984 JF - Radiocarbon AU - Srdoc, Dusan AU - Osmond, J K AU - Horvatincic, Nada AU - Dabous, Adel A AU - Obelic, Bogomil Y1 - 1994 PY - 1994 DA - 1994 SP - 203 EP - 219 PB - American Journal of Science, New Haven, CT VL - 36 IS - 2 SN - 0033-8222, 0033-8222 KW - methods KW - waterfalls KW - karst KW - Europe KW - Plitvice Lakes KW - uranium disequilibrium KW - U-234/Th-230 KW - Southern Europe KW - sedimentary rocks KW - carbon KW - absolute age KW - organic carbon KW - faults KW - speleothems KW - Quaternary KW - organic compounds KW - fluvial features KW - travertine KW - Pleistocene KW - Croatia KW - Wurm KW - uranium KW - carbonate rocks KW - solution features KW - carbonates KW - Eastern Alps KW - isotopes KW - Cretaceous KW - Yugoslavia KW - Alps KW - upper Pleistocene KW - Cenozoic KW - radioactive isotopes KW - dates KW - Triassic KW - Upper Triassic KW - organic materials KW - Jurassic KW - isotope ratios KW - Mesozoic KW - calcite KW - metals KW - Dinaric Alps KW - thorium KW - U-238/U-234 KW - C-14 KW - actinides KW - growth KW - 03:Geochronology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50117404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiocarbon&rft.atitle=Radiocarbon+and+uranium-series+dating+of+the+Plitvice+lakes+travertines&rft.au=Srdoc%2C+Dusan%3BOsmond%2C+J+K%3BHorvatincic%2C+Nada%3BDabous%2C+Adel+A%3BObelic%2C+Bogomil&rft.aulast=Srdoc&rft.aufirst=Dusan&rft.date=1994-01-01&rft.volume=36&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Radiocarbon&rft.issn=00338222&rft_id=info:doi/ L2 - http://www.radiocarbon.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - Number of references - 74 N1 - PubXState - CT N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - RACAAT N1 - SubjectsTermNotLitGenreText - absolute age; actinides; Alps; C-14; calcite; carbon; carbonate rocks; carbonates; Cenozoic; Cretaceous; Croatia; dates; Dinaric Alps; Eastern Alps; Europe; faults; fluvial features; growth; isotope ratios; isotopes; Jurassic; karst; Mesozoic; metals; methods; organic carbon; organic compounds; organic materials; Pleistocene; Plitvice Lakes; Quaternary; radioactive isotopes; sedimentary rocks; solution features; Southern Europe; speleothems; thorium; travertine; Triassic; U-234/Th-230; U-238/U-234; upper Pleistocene; Upper Triassic; uranium; uranium disequilibrium; waterfalls; Wurm; Yugoslavia ER - TY - JOUR T1 - Radionuclides in late Wisconsinan and Recent sediments of eastern Long Island, New York AN - 50070245; 1996-020066 JF - Northeastern Geology AU - Laymon, Charles AU - Lakatos, Stephen AU - Ward, Thomas AU - Harbottle, Garman AU - Lin, W J Y1 - 1994 PY - 1994 DA - 1994 SP - 194 EP - 201 PB - Rensselaer Polytechnic Institute, Department of Geology, Troy, NY VL - 16 IS - 3-4 SN - 0194-1453, 0194-1453 KW - upper Wisconsinan KW - United States KW - Connecticut Lobe KW - Laurentide ice sheet KW - glaciation KW - isotopes KW - Th-232 KW - K-40 KW - beach placers KW - Holocene KW - Wisconsinan KW - upper Pleistocene KW - Cenozoic KW - radioactive isotopes KW - sediments KW - Long Island KW - heavy metals KW - Quaternary KW - alkali metals KW - placers KW - New York KW - metals KW - potassium KW - thorium KW - Pleistocene KW - uranium KW - U-238 KW - actinides KW - 24:Quaternary geology KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50070245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Northeastern+Geology&rft.atitle=Radionuclides+in+late+Wisconsinan+and+Recent+sediments+of+eastern+Long+Island%2C+New+York&rft.au=Laymon%2C+Charles%3BLakatos%2C+Stephen%3BWard%2C+Thomas%3BHarbottle%2C+Garman%3BLin%2C+W+J&rft.aulast=Laymon&rft.aufirst=Charles&rft.date=1994-01-01&rft.volume=16&rft.issue=3-4&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Northeastern+Geology&rft.issn=01941453&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 28 N1 - PubXState - NY N1 - Document feature - 3 tables, geol. sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - actinides; alkali metals; beach placers; Cenozoic; Connecticut Lobe; glaciation; heavy metals; Holocene; isotopes; K-40; Laurentide ice sheet; Long Island; metals; New York; placers; Pleistocene; potassium; Quaternary; radioactive isotopes; sediments; Th-232; thorium; U-238; United States; upper Pleistocene; upper Wisconsinan; uranium; Wisconsinan ER - TY - JOUR T1 - Fishery resources, consumption and import trends, and biotechnology developments in the USA AN - 20127554; 9214046 AB - Consumption of seafood in the USA has increased over the last decade and this trend is expected to continue. The 1989 National Marine Fisheries Service consumption figure was 15.9 lb of edible meat per person per year. Total commercial landings were a record 8.5 x 10 super(9)lb in 1989, and imported edible products totalled 3.2 x 10 super(9)lb. The majority of the seafood supply in the USA was taken from wild populations. The aquaculture portion of this supply is also expected to increase. A substantial amount of seafood (600 x 10 super(6)lb of finfish and 300 x 10 super(6)lb of shellfish) is caught recreationally. About 70% of commercially produced seafood in the USA is sold fresh or frozen. Canned seafood constitutes approximately 25%, and smoked/cured products 5%, of the seafood consumed. The USA exported 1.4 x 10 super(9)lb of edible domestic fishery products in 1989. Landings by the seafood industry are fragmented, diversified, seasonal, complex, and difficult to manage. Studies are needed to monitor changing consumption trends and patterns. The processing, distribution, and merchandising of finfish and shellfish will require more emphasis to reduce cross-contamination. Over 20% of seafood consumed in the USA is derived from recreational or subsistence fishing. Attention should be given to (1) aquaculture, to produce high-quality, consistently available species; (2) landing, handling, distribution, and preparation of recreationally caught fish, to ensure consumer safety; (3) educating the industry and the consumer about safe handling practices, to reduce potential food-handling problems; (4) advances in biotechnology to insure adequate supply of exhaustable fishery resources; (5) developing international agreements to harmonize regulations and insure equivalence between domestic and imported products. JF - Fisheries research AU - Ahmed, Farid E AU - Anderson, Roger D AD - Biology Department, Brookhaven National Laboratory,, Upton, NY 11973, USA Y1 - 1994///0, PY - 1994 DA - 0, 1994 SP - 1 EP - 15 VL - 19 IS - 1-2 SN - 0165-7836, 0165-7836 KW - Ecology Abstracts; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Trade KW - Food KW - Handling KW - Development KW - Aquaculture KW - Fishery resources KW - Fishing KW - Cured products KW - Food technology KW - Fisheries KW - Consumers KW - Seafood KW - Fish culture KW - Marine KW - Meat KW - Landing statistics KW - USA KW - Processed fishery products KW - Marine aquaculture KW - Resource development KW - Internet KW - Biotechnology KW - Fishery products KW - Q3 08583:Shellfish culture KW - Q1 08626:Food technology KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08643:Marketing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20127554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fisheries+research&rft.atitle=Fishery+resources%2C+consumption+and+import+trends%2C+and+biotechnology+developments+in+the+USA&rft.au=Ahmed%2C+Farid+E%3BAnderson%2C+Roger+D&rft.aulast=Ahmed&rft.aufirst=Farid&rft.date=1994-01-01&rft.volume=19&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Fisheries+research&rft.issn=01657836&rft_id=info:doi/10.1016%2F0165-7836%2894%2990011-6 L2 - http://www.sciencedirect.com/science/journal/01657836 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - SuppNotes - Physical medium: Printed matter, Internet; (DBO; http://www.sciencedirect.com/science/journal/01657836 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Landing statistics; Processed fishery products; Food technology; Trade; Handling; Marine aquaculture; Consumers; Seafood; Resource development; Fishery resources; Fish culture; Biotechnology; Meat; Cured products; Fishing; Food; Fisheries; Development; Aquaculture; Internet; Fishery products; USA; Marine DO - http://dx.doi.org/10.1016/0165-7836(94)90011-6 ER - TY - JOUR T1 - XPS and XANES studies of uranium reduction by Clostridium sp AN - 13666959; S199851587 AB - The effect of uranyl acetate at 0-420 uM on the growth of Clostridium sp in oxygen-free cultures was assessed by measurements of gas, pH, bacterial numbers and acid metabolites. The latter were analysed by high performance liquid chromatography after filtration. Uranium(VI) and total uranium after oxidation were analysed spectroscopically. Uranium species in the solids and bacteria were assessed by X-ray absorption near-edge spectroscopy (XANES) and X-ray photoelectron spectroscopy (XPS). Uranyl ion at 210 and 420 uM severely reduced bacterial growth. Uranium(VI) was reduced to uranium(IV); uranium(III) was probably detected in bacterial cultures. Only growing or resting cells reduced uranium(VI): heat-killed cells, metabolites and the culture medium were not responsible. There are 31 references. JF - Environmental Science & Technology AU - Francis, A J AU - Dodge, C J AU - Lu, F AU - Halada, G P AU - Clayton, C R AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1994 PY - 1994 DA - 1994 SP - 636 EP - 639 VL - 28 IS - 4 SN - 0013-936X, 0013-936X KW - Analysis KW - Reduction KW - Aqualine Abstracts KW - AQ 00007:Industrial Effluents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13666959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=XPS+and+XANES+studies+of+uranium+reduction+by+Clostridium+sp&rft.au=Francis%2C+A+J%3BDodge%2C+C+J%3BLu%2C+F%3BHalada%2C+G+P%3BClayton%2C+C+R&rft.aulast=Francis&rft.aufirst=A&rft.date=1994-01-01&rft.volume=28&rft.issue=4&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Photodegradation of uranium-citrate complex with uranium recovery AN - 13664348; S199953297 AB - A method to recover uranium from citric acid extracts of contaminated soils and sludges was developed. On exposure to visible light, uranyl citrate complex showed photodegradation of citric acid to acetic acid and carbon dioxide with the precipitation of uranium and uranium trioxide. The photochemical degradation products of uranyl citrate complex were characterized under aerobic and anaerobic conditions using potentiometric titration, spectrophotometric analysis, gas chromatography, X-ray diffraction, X-ray absorption and X-ray photoelectron spectroscopy. The initial pH and presence of oxygen affected the rate and extent of photochemical degradation, the formation of intermediate organic degradation products and uranium speciation. Under aerobic conditions at pH 3.5, reaction products included acetic, acetoacetic, 3-oxoglutaric and malonic acids and acetone. At pH 6, 3-oxoglutaric and acetic acids were detected. The uranium(VI) ion was reduced to uranium(IV) and then reoxidized to uranium(VI) and precipitated as uranium trioxide. The complex was only partly degraded under anaerobic conditions and uranium precipitation was impeded by the presence of excess citric acid. JF - Environmental Science & Technology AU - Dodge, C J AU - Francis, A J AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1994 PY - 1994 DA - 1994 SP - 1300 EP - 1306 VL - 28 IS - 7 SN - 0013-936X, 0013-936X KW - Light KW - Malonic acid KW - Reduction KW - Aqualine Abstracts KW - AQ 00007:Industrial Effluents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13664348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Photodegradation+of+uranium-citrate+complex+with+uranium+recovery&rft.au=Dodge%2C+C+J%3BFrancis%2C+A+J&rft.aulast=Dodge&rft.aufirst=C&rft.date=1994-01-01&rft.volume=28&rft.issue=7&rft.spage=1300&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Estimation of upper limits on human radiation absorbed doses from carbon-11-labeled compounds. AN - 76108183; 8254413 AB - Radiation absorbed dose estimates for short-lived PET tracers are commonly based on biodistributions in rodents which (because of more rapid distribution and other species differences) may have limited relevance to humans. The initial purpose of this study was to estimate an intravenously injectable quantity of 11C which could not, on a priori grounds, exceed regulatory limits on radiation absorbed doses for individual organs. Upper limits on organ cumulative activities were estimated by assuming that 11C-labeled compounds are instantaneously distributed in the blood plasma, and then transferred solely and irreversibly to a single organ. The rate-constant (min-1) for each organ was taken to be its fractional cardiac output, since the plasma volume of 3 liters is recirculated each minute. The method was extended by using measured time courses of radioactivity in human arterial plasma available from previous PET studies with several 11C compounds in place of the assumption that the injected radioactivity was initially instantaneously distributed throughout the plasma. Calculations for 11C L-deprenyl, cogentin, cocaine, N-methylspiperone, putrescine and 2-deoxy-D-glucose, assuming transfer limited to a single organ, gave the kidneys rather than the thyroid as critical organ in each case. The upper-limit self-doses were 140, 210, 320, 360, 450 and 750 mrad/mCi, respectively, indicating that 34, 24, 15, 14 and 6.5 mCi, respectively, could be administered in a single PET study. These results suggest a strategy for human studies with 11C-labeled compounds: a preliminary study at the 3.5-mCi level would yield 11C arterial plasma data which could in turn be used to give a refined upper limit on radiation absorbed doses. For many 11C compounds, this strategy would demonstrate that sufficient radioactivity could be injected to give acceptable human PET images and would avoid the death of animals for biodistribution studies. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Gatley, S J AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1993/12// PY - 1993 DA - December 1993 SP - 2208 EP - 2215 VL - 34 IS - 12 SN - 0161-5505, 0161-5505 KW - Carbon Radioisotopes KW - 0 KW - Benztropine KW - 1NHL2J4X8K KW - Selegiline KW - 2K1V7GP655 KW - Spiperone KW - 4X6E73CJ0Q KW - 3-N-methylspiperone KW - 87539-19-3 KW - Deoxyglucose KW - 9G2MP84A8W KW - Cocaine KW - I5Y540LHVR KW - Putrescine KW - V10TVZ52E4 KW - Index Medicus KW - Papio KW - Selegiline -- pharmacokinetics KW - Spiperone -- pharmacokinetics KW - Animals KW - Humans KW - Mice KW - Tissue Distribution KW - Models, Biological KW - Benztropine -- pharmacokinetics KW - Putrescine -- pharmacokinetics KW - Benztropine -- analogs & derivatives KW - Dogs KW - Cocaine -- pharmacokinetics KW - Deoxyglucose -- pharmacokinetics KW - Spiperone -- analogs & derivatives KW - Carbon Radioisotopes -- pharmacokinetics KW - Radiation Dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76108183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Estimation+of+upper+limits+on+human+radiation+absorbed+doses+from+carbon-11-labeled+compounds.&rft.au=Gatley%2C+S+J&rft.aulast=Gatley&rft.aufirst=S&rft.date=1993-12-01&rft.volume=34&rft.issue=12&rft.spage=2208&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-01-07 N1 - Date created - 1994-01-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Use of active fluorescence to estimate phytoplankton photosynthesis in situ AN - 1808725879; PQ0003340509 AB - We describe the theory and practice of estimating photosynthetic rates from light-stimulated changes in the quantum yield of chlorophyll fluorescence. By means of a pump-and-probe fluorescence technique, where weak probe flashes are used to measure the change in the quantum yield of fluorescence induced by the strong pump flash, it is possible to derive the absolute absorption cross sections for photosystem 2, the quantum yield for photochemistry, and the maximum rate of photosynthetic electron transport at light saturation. In conjunction with a semiempirical biophysical model of photosynthesis, these parameters can be used to calculate the instantaneous rate of gross photosynthesis in situ under ambient irradiance. A profiling pump-and-probe fluorometer was constructed and interfaced with a CTD, and vertical profiles of variable fluorescence were obtained on four cruises in the northwest Atlantic Ocean. The derived photosynthetic rates were compared with concurrent estimates of production based on radiocarbon uptake. The correlation coefficient between the two estimates of primary production, normalized to Chl a, was 0.86; linear regression analysis yielded a slope of 1.06. There is a 3-4-fold range in the maximum change in the quantum yields of photochemistry and absorption cross-sections in natural phytoplankton communities. Uncertainties in the pump-and-probe-derived estimates of photosynthesis are primarily due to temporal mismatches between instantaneous and time-integrated measures of production and in biological variability in the ratio of the number of PS2 reaction centers to total Chl a. JF - Limnology and Oceanography AU - Kolber, Zbigniew AU - Falkowski, Paul G AD - Oceanographic and Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1993/12// PY - 1993 DA - December 1993 SP - 1646 EP - 1665 PB - Association for the Sciences of Limnology and Oceanography VL - 38 IS - 8 SN - 0024-3590, 0024-3590 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Photochemistry KW - Chlorophylls KW - Chlorophyll KW - Photosynthesis KW - Cross-sections KW - Phytoplankton KW - Primary production KW - Light absorption KW - Absorption KW - Fluorescent indicators KW - Slopes KW - Fluorescence KW - Estimating KW - Profiling KW - Vertical profiles KW - Reaction centers KW - Irradiance KW - CTD profilers KW - Models KW - Yield KW - Regression analysis KW - ANW, Atlantic KW - Marine KW - Plankton surveys KW - CTD observations KW - Photosystem KW - Fluorimeters KW - Light effects KW - Presenilin 2 KW - Oceans KW - Pumps KW - Electron transport KW - AQ 00001:Water Resources and Supplies KW - Q1 08482:Ecosystems and energetics KW - SW 0810:General KW - K 03450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808725879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Use+of+active+fluorescence+to+estimate+phytoplankton+photosynthesis+in+situ&rft.au=Kolber%2C+Zbigniew%3BFalkowski%2C+Paul+G&rft.aulast=Kolber&rft.aufirst=Zbigniew&rft.date=1993-12-01&rft.volume=38&rft.issue=8&rft.spage=1646&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1993.38.8.1646 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Photochemistry; Plankton surveys; Chlorophylls; Fluorescence; Photosynthesis; CTD profilers; CTD observations; Profiling; Phytoplankton; Primary production; Fluorimeters; Vertical profiles; Light absorption; Pumps; Chlorophyll; Irradiance; Photosystem; Models; Light effects; Presenilin 2; Oceans; Regression analysis; Fluorescent indicators; Electron transport; Reaction centers; Yield; Cross-sections; Estimating; Absorption; Slopes; ANW, Atlantic; Marine DO - http://dx.doi.org/10.4319/lo.1993.38.8.1646 ER - TY - JOUR T1 - Oxyanion surface structures on goethite AN - 52822022; 1996-047749 JF - Agronomy Abstracts AU - Fendorf, S E AU - Grossl, P R AU - Sparks, D L AU - Lamble, G M AU - Anonymous Y1 - 1993/11// PY - 1993 DA - November 1993 SP - 344 PB - American Society of Agronomy, Madison, WI VL - 85 SN - 0375-5495, 0375-5495 KW - water KW - soils KW - anions KW - sorption KW - goethite KW - crystal structure KW - X-ray spectra KW - absorption KW - chemical reactions KW - retention KW - oxides KW - spectra KW - heavy metals KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52822022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agronomy+Abstracts&rft.atitle=Oxyanion+surface+structures+on+goethite&rft.au=Fendorf%2C+S+E%3BGrossl%2C+P+R%3BSparks%2C+D+L%3BLamble%2C+G+M%3BAnonymous&rft.aulast=Fendorf&rft.aufirst=S&rft.date=1993-11-01&rft.volume=85&rft.issue=&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Agronomy+Abstracts&rft.issn=03755495&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Society of Agronomy, Crop Science Society of America and Soil Science Society of America; 1993 annual meetings N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - WI N1 - Last updated - 2012-06-07 N1 - CODEN - AGABBE N1 - SubjectsTermNotLitGenreText - absorption; anions; chemical reactions; crystal structure; goethite; heavy metals; oxides; retention; soils; sorption; spectra; water; X-ray spectra ER - TY - JOUR T1 - Seasonal, latitudinal, and secular variations in temperature trend: Evidence for influence of anthropogenic sulfate AN - 1671634584; 19554402 AB - Tropospheric aerosols increase the shortwave reflectivity of the Earth-atmosphere system both by scattering light directly, in the absence of clouds, and by enhancing cloud reflectivity. The radiative forcing of climate exerted by anthropogenic sulfate aerosols, derived mainly from SO sub(2) emitted from fossil fuel combustion, is opposite that due to anthropogenic greenhouse gases and is estimated to be of comparable average magnitude in Northern Hemisphere midlatitudes. However, persuasive evidence of climate response to this forcing has thus far been lacking. Here we examine patterns of seasonal and latitudinal variations in temperature anomaly trend for evidence of such a response. Pronounced minima in the rate of temperature increase in summer months in Northern Hemisphere midlatitudes are consistent with the latitudinal distribution of anthropogenic sulfate and changes in the rate of SO sub(2) emissions over the industrial era. JF - Geophysical Research Letters AU - Hunter, David E AU - Schwartz, Stephen E AU - Wagener, Richard AU - Benkovitz, Carmen M AD - Environmental Chemistry Division, Brookhaven National Laboratory. Y1 - 1993/11// PY - 1993 DA - Nov 1993 SP - 2455 EP - 2458 PB - American Geophysical Union, 2000 Florida Ave., N.W. Washington DC 20009 United States VL - 20 IS - 22 SN - 0094-8276, 0094-8276 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE); Aerospace & High Technology Database (AH) KW - Sulfates KW - Clouds KW - Aerosols KW - Reflectivity KW - Climate KW - Northern Hemisphere KW - Trends KW - Combustion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671634584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Seasonal%2C+latitudinal%2C+and+secular+variations+in+temperature+trend%3A+Evidence+for+influence+of+anthropogenic+sulfate&rft.au=Hunter%2C+David+E%3BSchwartz%2C+Stephen+E%3BWagener%2C+Richard%3BBenkovitz%2C+Carmen+M&rft.aulast=Hunter&rft.aufirst=David&rft.date=1993-11-01&rft.volume=20&rft.issue=22&rft.spage=2455&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1029%2F93GL02808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Last updated - 2015-04-09 DO - http://dx.doi.org/10.1029/93GL02808 ER - TY - JOUR T1 - Seasonal, latitudinal, and secular variations in temperature trend: Evidence for influence of anthropogenic sulfate AN - 1531007606; 19554402 AB - Tropospheric aerosols increase the shortwave reflectivity of the Earth-atmosphere system both by scattering light directly, in the absence of clouds, and by enhancing cloud reflectivity. The radiative forcing of climate exerted by anthropogenic sulfate aerosols, derived mainly from SO sub(2) emitted from fossil fuel combustion, is opposite that due to anthropogenic greenhouse gases and is estimated to be of comparable average magnitude in Northern Hemisphere midlatitudes. However, persuasive evidence of climate response to this forcing has thus far been lacking. Here we examine patterns of seasonal and latitudinal variations in temperature anomaly trend for evidence of such a response. Pronounced minima in the rate of temperature increase in summer months in Northern Hemisphere midlatitudes are consistent with the latitudinal distribution of anthropogenic sulfate and changes in the rate of SO sub(2) emissions over the industrial era. JF - Geophysical Research Letters AU - Hunter, David E AU - Schwartz, Stephen E AU - Wagener, Richard AU - Benkovitz, Carmen M AD - Environmental Chemistry Division, Brookhaven National Laboratory. Y1 - 1993/11// PY - 1993 DA - November 1993 SP - 2455 EP - 2458 PB - American Geophysical Union, 2000 Florida Ave., N.W. Washington DC 20009 United States VL - 20 IS - 22 SN - 0094-8276, 0094-8276 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE); Aerospace & High Technology Database (AH) KW - Sulfates KW - Clouds KW - Aerosols KW - Reflectivity KW - Climate KW - Northern Hemisphere KW - Trends KW - Combustion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1531007606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Seasonal%2C+latitudinal%2C+and+secular+variations+in+temperature+trend%3A+Evidence+for+influence+of+anthropogenic+sulfate&rft.au=Hunter%2C+David+E%3BSchwartz%2C+Stephen+E%3BWagener%2C+Richard%3BBenkovitz%2C+Carmen+M&rft.aulast=Hunter&rft.aufirst=David&rft.date=1993-11-01&rft.volume=20&rft.issue=22&rft.spage=2455&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1029%2F93GL02808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Last updated - 2017-01-05 DO - http://dx.doi.org/10.1029/93GL02808 ER - TY - JOUR T1 - Migration rates of volatile organic compounds in an unconsolidated sand and gravel aquifer system AN - 50307105; 1993-041466 JF - Ground Water AU - Naidu, J R AU - Paquette, D E AU - Porcelli, D R Y1 - 1993/10// PY - 1993 DA - October 1993 SP - 844 PB - National Water Well Association, Ground-Water Technology Division, Urbana, IL VL - 31 IS - 5 SN - 0017-467X, 0017-467X KW - organic materials KW - water quality KW - monitoring KW - landfills KW - water management KW - pollution KW - aquifers KW - models KW - volatiles KW - organic compounds KW - sampling KW - movement KW - volatile organic compounds KW - interpretation KW - water resources KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50307105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ground+Water&rft.atitle=Migration+rates+of+volatile+organic+compounds+in+an+unconsolidated+sand+and+gravel+aquifer+system&rft.au=Naidu%2C+J+R%3BPaquette%2C+D+E%3BPorcelli%2C+D+R&rft.aulast=Naidu&rft.aufirst=J&rft.date=1993-10-01&rft.volume=31&rft.issue=5&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=Ground+Water&rft.issn=0017467X&rft_id=info:doi/ L2 - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1745-6584 LA - English DB - GeoRef N1 - Conference title - 1993 AGWSE Educational Program on Chlorinated volatile organic compounds in ground water N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - PubXState - IL N1 - Last updated - 2016-10-25 N1 - CODEN - GRWAAP N1 - SubjectsTermNotLitGenreText - aquifers; interpretation; landfills; models; monitoring; movement; organic compounds; organic materials; pollution; sampling; volatile organic compounds; volatiles; water management; water quality; water resources ER - TY - JOUR T1 - Self-organized criticality in geophysics and elsewhere AN - 50285025; 1994-008791 JF - Abstracts with Programs - Geological Society of America AU - Bak, Per AU - Anonymous Y1 - 1993/10// PY - 1993 DA - October 1993 SP - 251 PB - Geological Society of America (GSA), Boulder, CO VL - 25 IS - 6 SN - 0016-7592, 0016-7592 KW - self-organization KW - mechanism KW - biologic evolution KW - rivers KW - volcanology KW - noise KW - models KW - volcanism KW - Sun KW - fluvial features KW - Gutenberg-Richter law KW - interpretation KW - fractals KW - crust KW - solar activity KW - geophysics KW - 15:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50285025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Self-organized+criticality+in+geophysics+and+elsewhere&rft.au=Bak%2C+Per%3BAnonymous&rft.aulast=Bak&rft.aufirst=Per&rft.date=1993-10-01&rft.volume=25&rft.issue=6&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1993 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - biologic evolution; crust; fluvial features; fractals; geophysics; Gutenberg-Richter law; interpretation; mechanism; models; noise; rivers; self-organization; solar activity; Sun; volcanism; volcanology ER - TY - JOUR T1 - Early diagenetic transformations of organically-bound sulfur in Peru margin sediments AN - 50276861; 1994-006883 JF - Abstracts with Programs - Geological Society of America AU - Eglinton, T I AU - Irvine, J AU - Sinninghe Damste, Jaap S AU - Schouten, S AU - de Leeuw, Jan W AU - Vairavamurthy, Appathurai AU - Manowitz, B AU - Anonymous Y1 - 1993/10// PY - 1993 DA - October 1993 SP - 19 PB - Geological Society of America (GSA), Boulder, CO VL - 25 IS - 6 SN - 0016-7592, 0016-7592 KW - maturity KW - Cenozoic KW - Monterey Formation KW - carbon KW - sediments KW - Peru KW - spectra KW - organic carbon KW - geochemistry KW - organic sulfur KW - organic materials KW - early diagenesis KW - continental margin KW - X-ray spectra KW - Miocene KW - thiophene KW - bitumens KW - Tertiary KW - South America KW - organic compounds KW - Neogene KW - diagenesis KW - chromatograms KW - sulfur KW - kerogen KW - sulfides KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50276861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Early+diagenetic+transformations+of+organically-bound+sulfur+in+Peru+margin+sediments&rft.au=Eglinton%2C+T+I%3BIrvine%2C+J%3BSinninghe+Damste%2C+Jaap+S%3BSchouten%2C+S%3Bde+Leeuw%2C+Jan+W%3BVairavamurthy%2C+Appathurai%3BManowitz%2C+B%3BAnonymous&rft.aulast=Eglinton&rft.aufirst=T&rft.date=1993-10-01&rft.volume=25&rft.issue=6&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1993 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - bitumens; carbon; Cenozoic; chromatograms; continental margin; diagenesis; early diagenesis; geochemistry; kerogen; maturity; Miocene; Monterey Formation; Neogene; organic carbon; organic compounds; organic materials; organic sulfur; Peru; sediments; South America; spectra; sulfides; sulfur; Tertiary; thiophene; X-ray spectra ER - TY - JOUR T1 - Geochemical incorporation of sulfur into organic matter; importance of hydrogen sulfide oxidation products AN - 50276566; 1994-006882 JF - Abstracts with Programs - Geological Society of America AU - Vairavamurthy, Appathurai AU - Anonymous Y1 - 1993/10// PY - 1993 DA - October 1993 SP - 19 PB - Geological Society of America (GSA), Boulder, CO VL - 25 IS - 6 SN - 0016-7592, 0016-7592 KW - organic materials KW - early diagenesis KW - oxidation KW - source rocks KW - Great South Bay KW - polysulfides KW - petroleum KW - hydrogen sulfide KW - genesis KW - acrylic acid KW - South America KW - organic compounds KW - marine sediments KW - diagenesis KW - sediments KW - sulfur KW - Peru KW - particulate materials KW - Long Island KW - geochemistry KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50276566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Geochemical+incorporation+of+sulfur+into+organic+matter%3B+importance+of+hydrogen+sulfide+oxidation+products&rft.au=Vairavamurthy%2C+Appathurai%3BAnonymous&rft.aulast=Vairavamurthy&rft.aufirst=Appathurai&rft.date=1993-10-01&rft.volume=25&rft.issue=6&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1993 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - acrylic acid; diagenesis; early diagenesis; genesis; geochemistry; Great South Bay; hydrogen sulfide; Long Island; marine sediments; organic compounds; organic materials; oxidation; particulate materials; Peru; petroleum; polysulfides; sediments; source rocks; South America; sulfur ER - TY - JOUR T1 - Geologic aspects of assessing risk; (super 137) Cs in the environment at Savannah River Site AN - 50267365; 1994-022137 JF - Abstracts with Programs - Geological Society of America AU - Pardi, R AU - Holtzman, S AU - Anonymous Y1 - 1993/10// PY - 1993 DA - October 1993 SP - 354 PB - Geological Society of America (GSA), Boulder, CO VL - 25 IS - 6 SN - 0016-7592, 0016-7592 KW - United States KW - soils KW - South Carolina KW - isotopes KW - pollutants KW - alkali metals KW - pollution KW - drinking water KW - radioactive isotopes KW - Cs-137 KW - cesium KW - metals KW - sediments KW - risk assessment KW - Savannah River Site KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50267365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Geologic+aspects+of+assessing+risk%3B+%28super+137%29+Cs+in+the+environment+at+Savannah+River+Site&rft.au=Pardi%2C+R%3BHoltzman%2C+S%3BAnonymous&rft.aulast=Pardi&rft.aufirst=R&rft.date=1993-10-01&rft.volume=25&rft.issue=6&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1993 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - alkali metals; cesium; Cs-137; drinking water; isotopes; metals; pollutants; pollution; radioactive isotopes; risk assessment; Savannah River Site; sediments; soils; South Carolina; United States ER - TY - JOUR T1 - Adsorption of radionuclides and metals below a mixed-waste disposal cell; implications for risk-assessment calculations AN - 50259217; 1994-027719 JF - Abstracts with Programs - Geological Society of America AU - Abitz, Richard J AU - Fuhrmann, Mark AU - Anonymous Y1 - 1993/10// PY - 1993 DA - October 1993 SP - 185 PB - Geological Society of America (GSA), Boulder, CO VL - 25 IS - 6 SN - 0016-7592, 0016-7592 KW - technetium KW - anions KW - alkaline earth metals KW - experimental studies KW - solutions KW - radium KW - isotopes KW - lead KW - adsorption KW - radioactive waste KW - ground water KW - vanadium KW - radioactive isotopes KW - barium KW - molybdenum KW - metals KW - cations KW - risk assessment KW - uranium KW - waste disposal KW - kinetics KW - actinides KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50259217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Adsorption+of+radionuclides+and+metals+below+a+mixed-waste+disposal+cell%3B+implications+for+risk-assessment+calculations&rft.au=Abitz%2C+Richard+J%3BFuhrmann%2C+Mark%3BAnonymous&rft.aulast=Abitz&rft.aufirst=Richard&rft.date=1993-10-01&rft.volume=25&rft.issue=6&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1993 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - actinides; adsorption; alkaline earth metals; anions; barium; cations; experimental studies; ground water; isotopes; kinetics; lead; metals; molybdenum; radioactive isotopes; radioactive waste; radium; risk assessment; solutions; technetium; uranium; vanadium; waste disposal ER - TY - JOUR T1 - Partial amelioration of AZT-induced macrocytic anemia in the mouse by folic acid. AN - 76081487; 8241950 AB - CBA/Ca mice being maintained on azidothymidine (AZT) in drinking water were given vitamin B12 and folate in an effort to ameliorate the macrocytic anemia associated with AZT administration. The B12/folate regimen was ineffectual, but higher doses of folate given daily resulted in an increase in RBC and a decrease in mean corpuscular hemoglobin (MCH) and polychromatophilic erythrocytes (PCE) while mean corpuscular volume (MCV) remained relatively constant. The implications of these findings on RBC production and hemoglobin synthesis are discussed. JF - Stem cells (Dayton, Ohio) AU - Cronkite, E AU - Bullis, J AU - Honikel, L AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993/09// PY - 1993 DA - September 1993 SP - 393 EP - 397 VL - 11 IS - 5 SN - 1066-5099, 1066-5099 KW - Zidovudine KW - 4B9XT59T7S KW - Folic Acid KW - 935E97BOY8 KW - Index Medicus KW - AIDS/HIV KW - Animals KW - Mice, Inbred CBA KW - Mice KW - Male KW - Anemia, Macrocytic -- chemically induced KW - Folic Acid -- therapeutic use KW - Anemia, Macrocytic -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76081487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+cells+%28Dayton%2C+Ohio%29&rft.atitle=Partial+amelioration+of+AZT-induced+macrocytic+anemia+in+the+mouse+by+folic+acid.&rft.au=Cronkite%2C+E%3BBullis%2C+J%3BHonikel%2C+L&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1993-09-01&rft.volume=11&rft.issue=5&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Stem+cells+%28Dayton%2C+Ohio%29&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-12-30 N1 - Date created - 1993-12-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The linear energy transfer dependence of excited singlet-state lifetimes of hydrocarbon liquids exposed to X rays. AN - 75930885; 8397427 AB - The absorption of X rays in liquids provides low-energy electrons in the energy range 2 to 20 keV when synchrotron radiation is used as the X ray source. Such low-energy electrons have short ranges and produce a dense track of ionization where dE/dx = 10(7) to 10(8) eV/cm. Fluorescent molecules provide a sensitive probe of the early-time structure of such tracks. From the extent of quenching of excited states and the consequent decrease in fluorescence lifetimes, the concentration of free radicals in the track can be inferred. Experiments done with the hydrocarbons cis-decalin and dodecane demonstrate this effect. In both hydrocarbons, the lifetimes (tau) are significantly smaller with excitation by X rays than with UV radiation, and tau-1 increases linearly with dE/dx. JF - Radiation research AU - Holroyd, R A AU - Preses, J M AU - Hanson, J C AD - Department of Chemistry, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1993/09// PY - 1993 DA - September 1993 SP - 312 EP - 314 VL - 135 IS - 3 SN - 0033-7587, 0033-7587 KW - Alkanes KW - 0 KW - Free Radicals KW - Hydrocarbons KW - Naphthalenes KW - Protons KW - n-dodecane KW - 11A386X1QH KW - decalin KW - 88451Q4XYF KW - Index Medicus KW - Space life sciences KW - Naphthalenes -- radiation effects KW - Energy Transfer KW - Alkanes -- radiation effects KW - Hydrocarbons -- radiation effects KW - Electrons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75930885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=The+linear+energy+transfer+dependence+of+excited+singlet-state+lifetimes+of+hydrocarbon+liquids+exposed+to+X+rays.&rft.au=Holroyd%2C+R+A%3BPreses%2C+J+M%3BHanson%2C+J+C&rft.aulast=Holroyd&rft.aufirst=R&rft.date=1993-09-01&rft.volume=135&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-10-21 N1 - Date created - 1993-10-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells. AN - 75879736; 8350395 AB - The adenovirus penton base protein has a cell rounding activity and may lyse endosomes during virus entry into the cytoplasm. We found that penton base that was expressed in Escherichia coli also caused cell rounding and that cells adhered to polystyrene wells that were coated with the protein. Mutant analysis showed that both properties required an Arg-Gly-Asp (RGD) sequence at residues 340 to 342 of penton base. In flat adherent cells, virus mutants with amino acid substitutions in the RGD sequence were delayed in virus reproduction and in the onset of viral DNA synthesis. In nonadherent or poorly spread cells, the kinetics of mutant virus reproduction were similar to those of wild-type adenovirus type 2. Expression of the mutant phenotype exclusively in the flat cells that we tested supports a model in which penton base interacts with an RGD-directed cell adhesion molecule during adenovirus uptake or uncoating. JF - Journal of virology AU - Bai, M AU - Harfe, B AU - Freimuth, P AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1993/09// PY - 1993 DA - September 1993 SP - 5198 EP - 5205 VL - 67 IS - 9 SN - 0022-538X, 0022-538X KW - Capsid Proteins KW - 0 KW - DNA, Viral KW - Oligodeoxyribonucleotides KW - Oligopeptides KW - penton protein, adenovirus KW - arginyl-glycyl-aspartic acid KW - 78VO7F77PN KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Genetic Variation KW - DNA, Viral -- biosynthesis KW - Base Sequence KW - HeLa Cells KW - Kinetics KW - Humans KW - Restriction Mapping KW - Molecular Sequence Data KW - Genetic Complementation Test KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Protein Binding KW - DNA Replication KW - Cell Line KW - Cell Adhesion KW - Virus Replication KW - Capsid -- isolation & purification KW - Capsid -- genetics KW - Adenoviruses, Human -- genetics KW - Oligopeptides -- genetics KW - Adenoviruses, Human -- physiology KW - Oligopeptides -- metabolism KW - Capsid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75879736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Mutations+that+alter+an+Arg-Gly-Asp+%28RGD%29+sequence+in+the+adenovirus+type+2+penton+base+protein+abolish+its+cell-rounding+activity+and+delay+virus+reproduction+in+flat+cells.&rft.au=Bai%2C+M%3BHarfe%2C+B%3BFreimuth%2C+P&rft.aulast=Bai&rft.aufirst=M&rft.date=1993-09-01&rft.volume=67&rft.issue=9&rft.spage=5198&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-09-13 N1 - Date created - 1993-09-13 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Virology. 1975 Oct;67(2):415-26 [810963] Science. 1992 Nov 6;258(5084):987-91 [1279805] J Mol Biol. 1978 Mar 25;120(1):97-120 [642007] Annu Rev Biochem. 1978;47:251-76 [354496] Virology. 1979 Jan 15;92(1):125-38 [419686] Virology. 1979 Apr 30;94(2):460-9 [452423] Cell. 1979 Jul;17(3):683-9 [476833] J Virol. 1979 Nov;32(2):623-8 [501803] Methods Enzymol. 1982;82 Pt A:803-31 [7078457] Cell. 1983 Feb;32(2):607-17 [6130853] Virology. 1983 Feb;125(1):175-93 [6299005] J Virol. 1984 Sep;51(3):687-94 [6471167] Mol Cell Biol. 1984 Aug;4(8):1528-33 [6333584] J Biol Chem. 1984 Dec 10;259(23):14350-3 [6334083] Cell. 1985 Jan;40(1):191-8 [3155652] Proc Natl Acad Sci U S A. 1985 Jan;82(2):488-92 [3881765] J Cell Biol. 1985 Jun;100(6):1948-54 [2581980] J Virol. 1985 Aug;55(2):442-9 [2862291] J Virol. 1985 Nov;56(2):439-48 [4057357] J Virol. 1987 Oct;61(10):3089-95 [3041031] J Virol. 1968 Oct;2(10):1064-75 [5723709] Virology. 1973 Apr;52(2):456-67 [4705382] Bacteriol Rev. 1973 Jun;37(2):103-35 [4200163] Eur J Biochem. 1973 Nov 1;39(1):37-42 [4203745] Science. 1987 Oct 23;238(4826):491-7 [2821619] J Virol. 1988 Jul;62(7):2321-8 [3373570] J Virol. 1990 Jan;64(1):37-50 [2104544] J Biol Chem. 1990 Jan 25;265(3):1327-32 [2153127] J Virol. 1990 Aug;64(8):3661-73 [2196380] Methods Enzymol. 1990;185:60-89 [2199796] Exp Cell Res. 1991 Aug;195(2):533-5 [1712734] Virology. 1993 Mar;193(1):348-55 [8438575] J Exp Med. 1958 Nov 1;108(5):713-29 [13587853] Virology. 1958 Dec;6(3):601-11 [13616174] Virology. 1958 Dec;6(3):770-1 [13616188] Mol Carcinog. 1992;5(2):102-6 [1554407] Virology. 1992 Jun;188(2):881-6 [1316685] Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6094-8 [1352882] Cell. 1992 Nov 13;71(4):671-8 [1423622] J Gen Virol. 1977 Jul;36(1):59-74 [886304] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - MIRD dose estimate report no. 17: radiation absorbed dose estimates from inhaled krypton-81m gas in lung imaging. AN - 75843757; 8326403 JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Atkins, H L AU - Robertson, J S AU - Akabani, G AD - Medical Dept., Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993/08// PY - 1993 DA - August 1993 SP - 1382 EP - 1384 VL - 34 IS - 8 SN - 0161-5505, 0161-5505 KW - Krypton KW - 5I8I620HVX KW - Index Medicus KW - Humans KW - Administration, Inhalation KW - Radionuclide Imaging KW - Radionuclide Generators KW - Radiation Dosage KW - Krypton -- administration & dosage KW - Lung -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75843757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=MIRD+dose+estimate+report+no.+17%3A+radiation+absorbed+dose+estimates+from+inhaled+krypton-81m+gas+in+lung+imaging.&rft.au=Atkins%2C+H+L%3BRobertson%2C+J+S%3BAkabani%2C+G&rft.aulast=Atkins&rft.aufirst=H&rft.date=1993-08-01&rft.volume=34&rft.issue=8&rft.spage=1382&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-12 N1 - Date created - 1993-08-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Wavelengths effective in induction of malignant melanoma. AN - 75873795; 8341684 AB - It is generally agreed that sunlight exposure is one of the etiologic agents in malignant melanoma of fair-skinned individuals. However, the wavelengths responsible for tumorigenesis are not known, although DNA is assumed to be the target because individuals defective in the repair of UV damage to DNA are several thousandfold more prone to the disease than the average population. Heavily pigmented backcross hybrids of the genus Xiphophorus (platyfish and swordtails) are very sensitive to melanoma induction by single exposures to UV. We irradiated groups of five 6-day-old fish with narrow wavelength bands at 302, 313, 365, 405, and 436 nm and scored the irradiated animals for melanomas 4 months later. We used several exposures at each wavelength to obtain estimates of the sensitivity for melanoma induction as a function of exposure and wavelength. The action spectrum (sensitivity per incident photon as a function of wavelength) for melanoma induction shows appreciable sensitivity at 365, 405, and probably 436 nm, suggesting that wavelengths not absorbed directly in DNA are effective in induction. We interpret the results as indicating that light energy absorbed in melanin is effective in inducing melanomas in this animal model and that, in natural sunlight, 90-95% of melanoma induction may be attributed to wavelengths > 320 nm--the UV-A and visible spectral regions. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Setlow, R B AU - Grist, E AU - Thompson, K AU - Woodhead, A D AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993/07/15/ PY - 1993 DA - 1993 Jul 15 SP - 6666 EP - 6670 VL - 90 IS - 14 SN - 0027-8424, 0027-8424 KW - Index Medicus KW - Animals KW - Skin Pigmentation -- genetics KW - Spectrophotometry, Ultraviolet KW - Biological Assay KW - Dose-Response Relationship, Radiation KW - Ultraviolet Rays KW - Skin -- radiation effects KW - Skin -- pathology KW - Melanoma, Experimental -- pathology KW - Melanoma, Experimental -- etiology KW - Cyprinodontiformes -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75873795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Wavelengths+effective+in+induction+of+malignant+melanoma.&rft.au=Setlow%2C+R+B%3BGrist%2C+E%3BThompson%2C+K%3BWoodhead%2C+A+D&rft.aulast=Setlow&rft.aufirst=R&rft.date=1993-07-15&rft.volume=90&rft.issue=14&rft.spage=6666&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-30 N1 - Date created - 1993-08-30 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Cancer Res. 1993 May 15;53(10 Suppl):2249-55 [8485710] Science. 1993 Feb 5;259(5096):816-9 [8430335] Proc Natl Acad Sci U S A. 1974 Sep;71(9):3363-6 [4530308] Photochem Photobiol. 1982 Aug;36(2):187-91 [7122713] Carcinogenesis. 1984 Apr;5(4):511-4 [6705149] Photochem Photobiol. 1984 Feb;39(2):183-9 [6709724] Mutat Res. 1984 Nov;129(2):251-8 [6095076] Carcinogenesis. 1986 Nov;7(11):1829-36 [3769130] Radiat Res. 1987 May;110(2):244-54 [3575654] Proc Natl Acad Sci U S A. 1989 Jul;86(14):5605-9 [2748607] Nature. 1989 Oct 5;341(6241):415-21 [2797166] Proc Natl Acad Sci U S A. 1989 Nov;86(22):8922-6 [2813430] Photochem Photobiol. 1991 Apr;53(4):559-63 [1857749] Pigment Cell Res. 1991 Feb;4(1):7-29 [1924175] World J Surg. 1992 Mar-Apr;16(2):157-65 [1561794] J Exp Zool. 1971 Feb;176(2):147-68 [5559225] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - X-ray absorption spectroscopy determination of oxidation sites AN - 51443476; 2007-047693 JF - Meteoritics AU - Bajt, S AU - Sutton, R AU - Smith, J V AU - King, Trude V V AU - Ridley, Ian Y1 - 1993/07// PY - 1993 DA - July 1993 SP - 320 PB - Arizona State University, Center for Meteorite Studies, Tempe, AZ VL - 28 IS - 3 SN - 0026-1114, 0026-1114 KW - meteorites KW - X-ray absorption spectra KW - oxidation KW - spectra KW - interpretation KW - geochemistry KW - 05B:Petrology of meteorites and tektites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51443476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Meteoritics&rft.atitle=X-ray+absorption+spectroscopy+determination+of+oxidation+sites&rft.au=Bajt%2C+S%3BSutton%2C+R%3BSmith%2C+J+V%3BKing%2C+Trude+V+V%3BRidley%2C+Ian&rft.aulast=Bajt&rft.aufirst=S&rft.date=1993-07-01&rft.volume=28&rft.issue=3&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Meteoritics&rft.issn=00261114&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 56th annual meeting of the Meteoritical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 6 N1 - PubXState - AZ N1 - Last updated - 2012-06-07 N1 - CODEN - MERTAW N1 - SubjectsTermNotLitGenreText - geochemistry; interpretation; meteorites; oxidation; spectra; X-ray absorption spectra ER - TY - JOUR T1 - Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. AN - 75838468; 8101394 AB - Decreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self-administration, positron emission tomography and a dual-tracer approach was used to examine dopamine D2 receptor availability and regional brain glucose metabolism in cocaine abusers. When compared to normal controls, cocaine abusers showed significant decreases in dopamine D2 receptor availability which persisted 3-4 months after detoxification. Decreases in dopamine D2 receptor availability were associated with decreased metabolism in several regions of the frontal lobes, most markedly orbito-frontal cortex and cingulate gyri. Dopamine dysregulation of these brain areas which are involved in the channeling of drive and affect could lead to loss of control resulting in compulsive drug-taking behavior. JF - Synapse (New York, N.Y.) AU - Volkow, N D AU - Fowler, J S AU - Wang, G J AU - Hitzemann, R AU - Logan, J AU - Schlyer, D J AU - Dewey, S L AU - Wolf, A P AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 169 EP - 177 VL - 14 IS - 2 SN - 0887-4476, 0887-4476 KW - Dopamine Agents KW - 0 KW - Receptors, Dopamine D2 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Spiperone KW - 4X6E73CJ0Q KW - 3-N-methylspiperone KW - 87539-19-3 KW - Deoxyglucose KW - 9G2MP84A8W KW - Cocaine KW - I5Y540LHVR KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Spiperone -- pharmacokinetics KW - Reference Values KW - Humans KW - Glucose -- metabolism KW - Adult KW - Deoxyglucose -- analogs & derivatives KW - Tomography, Emission-Computed KW - Spiperone -- analogs & derivatives KW - Brain -- diagnostic imaging KW - Male KW - Dopamine Agents -- pharmacokinetics KW - Frontal Lobe -- metabolism KW - Substance-Related Disorders -- metabolism KW - Receptors, Dopamine D2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75838468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Decreased+dopamine+D2+receptor+availability+is+associated+with+reduced+frontal+metabolism+in+cocaine+abusers.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWang%2C+G+J%3BHitzemann%2C+R%3BLogan%2C+J%3BSchlyer%2C+D+J%3BDewey%2C+S+L%3BWolf%2C+A+P&rft.aulast=Volkow&rft.aufirst=N&rft.date=1993-06-01&rft.volume=14&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-08-18 N1 - Date created - 1993-08-18 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - SPECT and planar brain imaging in crack abuse: iodine-123-iodoamphetamine uptake and localization. AN - 75768713; 8509856 AB - The uptake, distribution, and clearance properties of 123I-IMP in the brain were evaluated in controls and asymptomatic crack users to investigate cerebral blood flow alterations in crack abuse. Serial dynamic planar images of the brain (0-25 min), SPECT of the brain (0.5 hr and 4 hr) and whole-body scans (75 min) were obtained in 21 crack abusers and 21 control subjects. Major observations include: (a) foci of abnormally reduced 123I-IMP activity mainly in the frontal and parieto-occipital cortex or marked irregularities in the uptake of 123I-IMP throughout the cerebral cortex consistent with moderate to severe disruption in regional cerebral blood flow were observed on the 0.5 hr SPECT images of 16/21 asymptomatic crack users; (b) no correlation could be demonstrated between the incidence or severity of SPECT perfusion abnormality with the frequency, amount or length of time of crack use; (c) focal perfusion defects observed in 6/21 crack users on the 0.5-hr SPECT images partially or completely filled-in on delayed SPECT at 4 hr in four of six subjects; (d) the rate of cerebral uptake of 123I-IMP in crack users averaged 23% less than observed in control subjects over the first 25 min after tracer administration; and (e) 123I-IMP activity reaching the brain of cigarette smoking control subjects (n = 14) at 25 min after injection averaged 42.5% less than in nonsmoking controls (n = 7). Quantitative measurements of the uptake and distribution properties of 123I-IMP in the brain proved to be an objective, sensitive and useful measure of regional cerebral blood flow in crack abuse. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Weber, D A AU - Franceschi, D AU - Ivanovic, M AU - Atkins, H L AU - Cabahug, C AU - Wong, C T AU - Susskind, H AD - Medical Department, Brookhaven National Laboratory, Upton, New York. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 899 EP - 907 VL - 34 IS - 6 SN - 0161-5505, 0161-5505 KW - Amphetamines KW - 0 KW - Crack Cocaine KW - Iodine Radioisotopes KW - Iofetamine KW - C2A5X08042 KW - Index Medicus KW - Smoking -- physiopathology KW - Humans KW - Adult KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Tomography, Emission-Computed, Single-Photon KW - Cerebrovascular Circulation -- physiology KW - Brain -- blood supply KW - Substance-Related Disorders -- diagnostic imaging KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75768713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=SPECT+and+planar+brain+imaging+in+crack+abuse%3A+iodine-123-iodoamphetamine+uptake+and+localization.&rft.au=Weber%2C+D+A%3BFranceschi%2C+D%3BIvanovic%2C+M%3BAtkins%2C+H+L%3BCabahug%2C+C%3BWong%2C+C+T%3BSusskind%2C+H&rft.aulast=Weber&rft.aufirst=D&rft.date=1993-06-01&rft.volume=34&rft.issue=6&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-07-09 N1 - Date created - 1993-07-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Are stem cells exposed to ionizing radiation in vivo as effective as nonirradiated transfused stem cells in restoring hematopoiesis? AN - 75761436; 8500580 AB - Are the stem cells that survive graded doses of ionizing radiation as effective in restoring hematopoiesis in irradiated mice as transfused nonirradiated stem cells? This question was addressed by determining animal dose mortality and 10-day colony-forming units (CFU-S) survival curves and then replotting the percent animal survival against the number of CFU-S surviving the different doses of radiation, and by determining the number of nonirradiated CFU-S injected into fatally irradiated mice that result in a CFU-S dose mortality response curve. The number of CFU-S surviving per mouse after doses of radiation resulting in 95, 50 and 5% animal survival were calculated to be 520, 300 and 153, respectively. From the transfused CFU-S dose mortality curve of otherwise fatally irradiated mice (8.5 Gy), the number of transfused normal CFU-S required for 95, 50 and 5% animal survival was estimated to be 153, 24 and 3, respectively. The ratios of surviving CFU-S to nonirradiated, injected CFU-S are: at 95% survival (6.3 Gy), 3.4; at 50% survival (6.88 Gy), 12.5; and at 5% survival (7.4 Gy), 51.0. These data show that, in addition to a reduced number of CFU-S, as radiation dose increases, the quality of surviving CFU-S responsible for 30-day survival decreases. By implication, the long-term repopulating cell (LTRC) that is now known not to be the 10-day CFU-S must also decrease. JF - Experimental hematology AU - Cronkite, E P AU - Inoue, T AU - Hirabayashi, Y AU - Bullis, J AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993/06// PY - 1993 DA - June 1993 SP - 823 EP - 825 VL - 21 IS - 6 SN - 0301-472X, 0301-472X KW - Index Medicus KW - Bone Marrow Cells KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Dose-Response Relationship, Radiation KW - Cell Survival -- radiation effects KW - Colony-Forming Units Assay KW - Time Factors KW - Stem Cell Transplantation KW - Hematopoiesis -- physiology KW - Blood Component Transfusion KW - Hematopoietic Stem Cells -- physiology KW - Hematopoietic Stem Cells -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75761436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+hematology&rft.atitle=Are+stem+cells+exposed+to+ionizing+radiation+in+vivo+as+effective+as+nonirradiated+transfused+stem+cells+in+restoring+hematopoiesis%3F&rft.au=Cronkite%2C+E+P%3BInoue%2C+T%3BHirabayashi%2C+Y%3BBullis%2C+J&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1993-06-01&rft.volume=21&rft.issue=6&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Experimental+hematology&rft.issn=0301472X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-29 N1 - Date created - 1993-06-29 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Ultraviolet radiation-induced DNA damage and its photorepair in the skin of the platyfish Xiphophorus. AN - 75744932; 8485710 AB - Fluence response relationships for the induction of DNA damage in the skin of UV-irradiated Xiphophorus fish were obtained by quantitative gel electrophoresis of unlabeled DNA following extraction and treatment with an enzyme preparation that makes single strand breaks next to cyclobutane pyrimidine dimers. A buffer containing 7 M urea minimized the degradation of DNA during extraction and gave reproducible results. The shapes of fluence response curves for the production of dimers by sun lamp irradiation (lambda > 290 nm) or 302 nm in the dermis of grown fish were similar. Photoreversal of dimers was readily observed by black light exposure or from the longer wavelengths (> 304 nm) from sun lamps. As expected, the number of pyrimidine dimers/incident fluence in young fish skin was considerably higher on the irradiated side of immobilized fish than it was in swimming (randomly moving) fish, and the shape of the fluence response curves was linear for all wavelengths used lambda > 290, 302, and 313 nm. On the other hand, young fish irradiated from above with lambda > 290 nm showed a less than linear relationship between pyrimidine dimers in their skin and radiation fluence because most exposure occurred on the dorsal rim of fish skin; thus, some cells in that skin were exposed to high fluences while others were not, leading to a heterogenous population of cells. Values of dimers produced were also much less than in immobilized fish. The pigment melanin decreased the number of dimers in the epidermis of grown fish exposed to lambda > 290, 302, or 313 nm, or in the dermis of fish following 302 nm, thus conferring protection against this kind of damage. No dimers were detected in the epidermis of fish exposed to 365 nm. The dimers produced at 302 and 313 nm at tumoricidal exposures correspond to 1 dimer in 10(5) base pairs. JF - Cancer research AU - Ahmed, F E AU - Setlow, R B AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1993/05/15/ PY - 1993 DA - 1993 May 15 SP - 2249 EP - 2255 VL - 53 IS - 10 Suppl SN - 0008-5472, 0008-5472 KW - X-mrk KW - Melanins KW - 0 KW - Pyrimidine Dimers KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Skin Physiological Phenomena KW - Neoplasms, Radiation-Induced -- etiology KW - Pyrimidine Dimers -- metabolism KW - Humans KW - Melanoma -- etiology KW - DNA -- analysis KW - Disease Models, Animal KW - Melanins -- physiology KW - Fibroblasts -- radiation effects KW - DNA -- radiation effects KW - Female KW - Male KW - DNA Repair -- radiation effects KW - DNA Repair -- physiology KW - DNA Damage -- physiology KW - Skin -- radiation effects KW - Ultraviolet Rays -- adverse effects KW - Cyprinodontiformes -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75744932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Ultraviolet+radiation-induced+DNA+damage+and+its+photorepair+in+the+skin+of+the+platyfish+Xiphophorus.&rft.au=Ahmed%2C+F+E%3BSetlow%2C+R+B&rft.aulast=Ahmed&rft.aufirst=F&rft.date=1993-05-15&rft.volume=53&rft.issue=10+Suppl&rft.spage=2249&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-10 N1 - Date created - 1993-06-10 N1 - Date revised - 2017-02-17 N1 - Gene symbol - X-mrk N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Site environmental report for calendar year 1992 AN - 52656775; 1998-002552 AB - This report documents the results of the Environmental Monitoring Program at BNL and presents summary information about environmental compliance for 1992. To evaluate the effect of BNL operations on the local environment, measurements of direct radiation, and a variety of radionuclides and chemical compounds in ambient air, soil, sewage effluent, surface water, ground water and vegetation were made at the BNL site and at sites adjacent to the Laboratory. Brookhaven National Laboratory's compliance with all applicable guides, standards, and limits for radiological and nonradiological emissions to the environment were evaluated. Among the permitted facilities, only the discharge from the Sewage Treatment Plant (STP) to the Peconic River exceeded, on occasion only, the fecal and total coliform concentration limits at the discharge point. This was later attributed to off-site Contractor Laboratory quality assurance problems. The environmental monitoring data has continued to demonstrate, besides the site specific contamination of ground water and soil resulting from past operations, that compliance was achieved with environmental laws and regulations governing emission and discharge of materials to the environment, and that the environmental impacts at BNL are minimal and pose no threat to the public or to the environment. This report meets the requirements of DOE Orders 5484.1, Environmental Protection, Safety, and Health Protection Information reporting requirements and 5400.1, General Environmental Protection Programs. JF - BNL (Brookhaven National Laboratory) AU - Naidu, J R AU - Royce, B A AU - Miltenberger, R P Y1 - 1993/05// PY - 1993 DA - May 1993 SP - 227 PB - Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY SN - 0197-8659, 0197-8659 KW - soils KW - protection KW - monitoring KW - isotopes KW - site exploration KW - regulations KW - background level KW - pollution KW - standardization KW - seepage KW - radioactive waste KW - ground water KW - radioactive isotopes KW - detection KW - report KW - waste disposal KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52656775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Naidu%2C+J+R%3BRoyce%2C+B+A%3BMiltenberger%2C+R+P&rft.aulast=Naidu&rft.aufirst=J&rft.date=1993-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Site+environmental+report+for+calendar+year+1992&rft.title=Site+environmental+report+for+calendar+year+1992&rft.issn=01978659&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 1998-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number DE94017312NEG, Springfield, VA, United States N1 - PubXState - NY N1 - SuppNotes - Contract AC02-76CH00016 N1 - Last updated - 2012-06-07 N1 - CODEN - BNLRD9 N1 - SubjectsTermNotLitGenreText - background level; detection; ground water; isotopes; monitoring; pollution; protection; radioactive isotopes; radioactive waste; regulations; report; seepage; site exploration; soils; standardization; waste disposal ER - TY - JOUR T1 - Rapid radiochemical and chemical quality control of [11C]putrescine. AN - 75691065; 8472030 AB - A short (4.6 x 50 mm) cation exchange column was used in conjunction with conductivity and radioactivity detectors to determine the radiochemical purity (> 99%) and specific radioactivity (0.5-1.0 Ci/mu mol) of [1-11C]putrescine prepared via Michael addition of [11C]cyanide to acrylonitrile. The absence of acrylonitrile, a rodent carcinogen, from the final preparation was verified at the 50 ng level capillary vapor-phase chromatography (VPC) using a nitrogen-phosphorus detector. Routine VPC analysis using a Poropak Q column and flame ionization detection showed that preparations contained no more than 1 microgram of acrylonitrile. JF - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine AU - Gatley, S J AU - Ferrieri, R A AU - Fowler, J S AU - MacGregor, R R AU - Wolf, A P AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 765 EP - 767 VL - 44 IS - 4 SN - 0969-8043, 0969-8043 KW - Carbon Radioisotopes KW - 0 KW - Carcinogens KW - Acrylonitrile KW - MP1U0D42PE KW - Putrescine KW - V10TVZ52E4 KW - Index Medicus KW - Time Factors KW - Quality Control KW - Acrylonitrile -- isolation & purification KW - Putrescine -- standards KW - Carcinogens -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75691065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+radiation+and+isotopes+%3A+including+data%2C+instrumentation+and+methods+for+use+in+agriculture%2C+industry+and+medicine&rft.atitle=Rapid+radiochemical+and+chemical+quality+control+of+%5B11C%5Dputrescine.&rft.au=Gatley%2C+S+J%3BFerrieri%2C+R+A%3BFowler%2C+J+S%3BMacGregor%2C+R+R%3BWolf%2C+A+P&rft.aulast=Gatley&rft.aufirst=S&rft.date=1993-04-01&rft.volume=44&rft.issue=4&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=Applied+radiation+and+isotopes+%3A+including+data%2C+instrumentation+and+methods+for+use+in+agriculture%2C+industry+and+medicine&rft.issn=09698043&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-05-19 N1 - Date created - 1993-05-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Oxidation state of sulfur in thiosulfate and implications for anaerobic energy metabolism AN - 50357548; 1993-010430 AB - XANES spectroscopy indicates that the two different S atoms in thiosulphate have charge densities corresponding with +5 and -1 oxidation states which support a redox mechanism in the disproportionation of thiosulphate to sulphate and sulphide. JF - Geochimica et Cosmochimica Acta AU - Vairavamurthy, A AU - Manowitz, B AU - Luther, G W, III AU - Jeon, Y Y1 - 1993/04// PY - 1993 DA - April 1993 SP - 1619 EP - 1623 PB - Pergamon, Oxford VL - 57 IS - 7 SN - 0016-7037, 0016-7037 KW - marine sediments KW - experimental studies KW - metabolism KW - oxidation KW - thiosulfate KW - sediments KW - sulfur KW - anaerobic environment KW - Eh KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50357548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Oxidation+state+of+sulfur+in+thiosulfate+and+implications+for+anaerobic+energy+metabolism&rft.au=Vairavamurthy%2C+A%3BManowitz%2C+B%3BLuther%2C+G+W%2C+III%3BJeon%2C+Y&rft.aulast=Vairavamurthy&rft.aufirst=A&rft.date=1993-04-01&rft.volume=57&rft.issue=7&rft.spage=1619&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2F0016-7037%2893%2990020-W L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1993-01-01 N1 - Number of references - 20 N1 - Document feature - illus. N1 - SuppNotes - Letter N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - anaerobic environment; Eh; experimental studies; marine sediments; metabolism; oxidation; sediments; sulfur; thiosulfate DO - http://dx.doi.org/10.1016/0016-7037(93)90020-W ER - TY - JOUR T1 - A specific chromosomal deletion in murine leukemic cells induced by radiation with different qualities. AN - 75597769; 8440340 AB - G-banded metaphase chromosomes prepared from 14 male CBA/Ca mice with histologically confirmed myeloid leukemia (ML) were studied in an effort to identify specific chromosomal changes associated with radiation leukemogenesis. The chromosome studies were undertaken as part of a larger investigation of radiation carcinogenesis, in which mice were exposed to radiation of several different qualities, i.e., x-rays, gamma-rays and "monoenergetic" fast neutrons of 5 mean energies ranging from 0.2 to 14 MeV. The 14 ML cases showed no histologically phenotypic differences and they were transplantable in syngeneic mice. We detected a specific chromosomal deletion in 1 copy of mouse chromosome 2 at regions D-E in all radiation-induced ML cells, regardless of radiation quality. Our results strongly implicate the involvement of genes within or close to regions D-E of chromosome 2 in radiation leukemogenesis. In addition to the specific deletion in chromosome 2, loss or gain of the Y chromosome was also detected in some cells from 6 ML cases. Because this hypo- or hyperploidy occurred in only a small fraction of leukemic cells, a causative role in radiation leukemogenesis appears unlikely. JF - Experimental hematology AU - Rithidech, K N AU - Bond, V P AU - Cronkite, E P AU - Thompson, M H AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 427 EP - 431 VL - 21 IS - 3 SN - 0301-472X, 0301-472X KW - Index Medicus KW - Phenotype KW - Neutrons KW - Animals KW - X-Rays KW - Mice, Inbred CBA KW - Gamma Rays KW - Mice KW - Dose-Response Relationship, Radiation KW - Ploidies KW - Male KW - Chromosome Deletion KW - Leukemia, Myeloid -- genetics KW - Leukemia, Myeloid -- pathology KW - Chromosomes -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75597769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+hematology&rft.atitle=A+specific+chromosomal+deletion+in+murine+leukemic+cells+induced+by+radiation+with+different+qualities.&rft.au=Rithidech%2C+K+N%3BBond%2C+V+P%3BCronkite%2C+E+P%3BThompson%2C+M+H&rft.aulast=Rithidech&rft.aufirst=K&rft.date=1993-03-01&rft.volume=21&rft.issue=3&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Experimental+hematology&rft.issn=0301472X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-29 N1 - Date created - 1993-03-29 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Decreased cerebral response to inhibitory neurotransmission in alcoholics. AN - 75575693; 8382010 AB - OBJECTIVEChanges in gamma-aminobutyric acid (GABA)-benzodiazepine receptor function have been implicated in alcohol tolerance, withdrawal, and dependence. The purpose of this study was to investigate whether recently detoxified alcoholic subjects had abnormalities in brain GABA-benzodiazepine receptor function.METHODThe effect of 30 micrograms/kg of lorazepam on regional brain glucose metabolism was studied in 12 normal subjects and 10 alcoholic subjects with the use of positron emission tomography and [18F]fluorodeoxyglucose.RESULTSLorazepam decreased whole brain glucose metabolism in both the normal subjects (13% change) and the alcoholic subjects (10% change), and the response was correlated with the concentration of lorazepam in plasma. Whereas the normal and alcoholic subjects showed similar responses to lorazepam in occipital and cerebellar metabolism, the alcoholic subjects showed significantly less of a response than the comparison subjects in the thalamus, basal ganglia, and orbitofrontal cortex. The rate of response in the orbitofrontal cortex was significantly correlated with cerebellar metabolism at baseline.CONCLUSIONSThe alcoholic subjects had a blunted response to lorazepam that was specific to certain brain regions. The association between cerebellar metabolism and response to lorazepam suggests that the cerebellum may contribute to the decreased sensitivity to lorazepam which was seen in the alcoholic subjects. JF - The American journal of psychiatry AU - Volkow, N D AU - Wang, G J AU - Hitzemann, R AU - Fowler, J S AU - Wolf, A P AU - Pappas, N AU - Biegon, A AU - Dewey, S L AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993/03// PY - 1993 DA - March 1993 SP - 417 EP - 422 VL - 150 IS - 3 SN - 0002-953X, 0002-953X KW - Receptors, GABA-A KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Deoxyglucose KW - 9G2MP84A8W KW - Glucose KW - IY9XDZ35W2 KW - Lorazepam KW - O26FZP769L KW - Abridged Index Medicus KW - Index Medicus KW - Frontal Lobe -- drug effects KW - Occipital Lobe -- drug effects KW - Humans KW - Cerebellum -- metabolism KW - Cerebellum -- drug effects KW - Adult KW - Occipital Lobe -- metabolism KW - Deoxyglucose -- analogs & derivatives KW - Frontal Lobe -- metabolism KW - Tomography, Emission-Computed KW - Middle Aged KW - Neuropsychological Tests KW - Basal Ganglia -- drug effects KW - Male KW - Functional Laterality -- physiology KW - Basal Ganglia -- metabolism KW - Deoxyglucose -- metabolism KW - Brain -- physiopathology KW - Receptors, GABA-A -- physiology KW - Alcoholism -- diagnosis KW - Lorazepam -- blood KW - Glucose -- metabolism KW - Brain -- drug effects KW - Alcoholism -- metabolism KW - Brain -- metabolism KW - Alcoholism -- physiopathology KW - Lorazepam -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75575693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Decreased+cerebral+response+to+inhibitory+neurotransmission+in+alcoholics.&rft.au=Volkow%2C+N+D%3BWang%2C+G+J%3BHitzemann%2C+R%3BFowler%2C+J+S%3BWolf%2C+A+P%3BPappas%2C+N%3BBiegon%2C+A%3BDewey%2C+S+L&rft.aulast=Volkow&rft.aufirst=N&rft.date=1993-03-01&rft.volume=150&rft.issue=3&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-16 N1 - Date created - 1993-03-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Abscess scintigraphy with 99mTc-human immunoglobulin (IgG) using a one-step labeling method. AN - 75613170; 8448577 AB - It was shown earlier that non-specific human gamma globulin (IgG) labeled with 111In can be used as an agent for abscess localization. We describe experimental results with 99mTc-IgG in animals bearing abscesses and tumors using a one-step labeling method with 99mTc. We studied this compound in several animal models: mice bearing turpentine abscesses and subcutaneously transplanted sarcomas, in rats with turpentine or E. coli abscesses and intracerebrally implanted gliomas and in rabbits with E. coli or turpentine abscesses. Blood clearance was studied in dogs. It was found that the absolute concentration of 111In-IgG in abscess and tumor was higher than that of 99mTc-IgG. However, the abscess-to-tumor ratio was higher for 99mTc-IgG. The 99mTc-IgG images were of high quality and abscesses could be detected as early as 30 min post-injection (p.i.). It appears that 99mTc-IgG has many potential advantages over 111In-IgG because of better physical properties of 99mTc, simpler preparation, lower cost and greater availability and the possibility of using higher 99mTc doses. JF - Nuclear medicine and biology AU - Oster, Z H AU - Som, P AU - Rhodes, B A AU - Wong, C T AU - Cabahug, C AU - Sacker, D F AU - Wang, G J AU - Meinken, G E AD - Brookhaven National Laboratory, Medical Department, Upton, New York 11973. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 225 EP - 230 VL - 20 IS - 2 SN - 0969-8051, 0969-8051 KW - Immunoglobulin G KW - 0 KW - Immunoglobulins KW - Indium Radioisotopes KW - technetium Tc 99m immunoglobulin KW - Technetium KW - 7440-26-8 KW - Turpentine KW - 8006-64-2 KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Metabolic Clearance Rate KW - Mice KW - Rabbits KW - Tissue Distribution KW - Lung -- metabolism KW - Radionuclide Imaging KW - Rats KW - Mice, Inbred CBA KW - Rats, Inbred F344 KW - Turpentine -- toxicity KW - Dogs KW - Female KW - Neoplasms, Experimental -- diagnostic imaging KW - Sarcoma, Experimental -- diagnostic imaging KW - Escherichia coli Infections -- diagnostic imaging KW - Glioma -- diagnostic imaging KW - Escherichia coli Infections -- metabolism KW - Neoplasms, Experimental -- metabolism KW - Technetium -- pharmacokinetics KW - Sarcoma, Experimental -- metabolism KW - Abscess -- chemically induced KW - Immunoglobulins -- metabolism KW - Abscess -- diagnostic imaging KW - Indium Radioisotopes -- pharmacokinetics KW - Glioma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75613170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+medicine+and+biology&rft.atitle=Abscess+scintigraphy+with+99mTc-human+immunoglobulin+%28IgG%29+using+a+one-step+labeling+method.&rft.au=Oster%2C+Z+H%3BSom%2C+P%3BRhodes%2C+B+A%3BWong%2C+C+T%3BCabahug%2C+C%3BSacker%2C+D+F%3BWang%2C+G+J%3BMeinken%2C+G+E&rft.aulast=Oster&rft.aufirst=Z&rft.date=1993-02-01&rft.volume=20&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Nuclear+medicine+and+biology&rft.issn=09698051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-04-15 N1 - Date created - 1993-04-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Photon activation of iododeoxyuridine: biological efficacy of Auger electrons. AN - 75607077; 8438063 AB - Photon activation therapy is a binary system being investigated as a potential therapeutic modality to improve the treatment of malignancies, particularly the highly lethal and malignant brain tumor, glioblastoma multiforme. Its success relies upon the incorporation of a target atom in the immediate vicinity of a tumor cell's critical site, followed by the activation of this atom with photons of energies suitable for the induction of the photoelectric effect and its concomitant Auger cascades. The collective action of the Auger electrons imparts high-LET type damage at the critical site. Photon activation therapy uses iodine from stable iododeoxyuridine (IdUrd) as the target atom, and monochromatic photons above the K absorption edge of iodine (33.2 keV) as the activating agent. Although IdUrd is a cell-sensitizing agent, work described was designed to separate the biological efficacy due to sensitization from that of the Auger effect. Chinese hamster V79 cells with and without IdUrd in cellular DNA were irradiated at the X17B1 beam line in the National Synchroton Light Source of Brookhaven National Laboratory. Monochromatic photons above (33.4 keV) and below (32.9 keV) the K absorption edge were used to determine if any additional biological damage would accrue from the Auger cascades. The 33.4-keV photons were found to be a factor of 1.4 times more effective than 32.9-keV photons in damaging iodinated cells. The sensitizing effect, evaluated separately, was found to be a factor of 2.2 at 10% survival, regardless of photon energy. Thus the total therapeutic gain was 1.4 x 2.2 = 3.1. Irradiations of noniodinated control cells showed no difference in their response to energies above and below the iodine K edge. JF - Radiation research AU - Laster, B H AU - Thomlinson, W C AU - Fairchild, R G AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 219 EP - 224 VL - 133 IS - 2 SN - 0033-7587, 0033-7587 KW - Idoxuridine KW - LGP81V5245 KW - Index Medicus KW - Space life sciences KW - Animals KW - Electrons KW - Radiation KW - Cricetulus KW - Dose-Response Relationship, Radiation KW - Cell Line KW - Cricetinae KW - Idoxuridine -- pharmacology KW - Cell Survival -- drug effects KW - Cell Survival -- radiation effects KW - Idoxuridine -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75607077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Photon+activation+of+iododeoxyuridine%3A+biological+efficacy+of+Auger+electrons.&rft.au=Laster%2C+B+H%3BThomlinson%2C+W+C%3BFairchild%2C+R+G&rft.aulast=Laster&rft.aufirst=B&rft.date=1993-02-01&rft.volume=133&rft.issue=2&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-23 N1 - Date created - 1993-03-23 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Anemia induced in splenectomized mice by administration of rhG-CSF. AN - 75582641; 7678815 AB - Normal and splenectomized mice (SPLXM) were given rhG-CSF for 10 to 128 days and serial observations were made on blood counts for 128 days. After 10 days, mice were killed for histologic studies. All treatment schedules produced, in addition to elevated white blood counts, a macrocytic anemia which only partially responded to large doses of Epo. Stopping rhG-CSF treatment for 2 days resulted in the return of granulocytes, lymphocytes, monocytes, platelets and polychromatophilic erythrocytes to near normal levels, indicating a need for the continued presence of rhG-CSF to maintain peripheral blood increases. Treatment of normal and SPLXM with rhG-CSF induced marked granulocytic hyperplasia of the bone marrow with expansion of the granulocytic marrow into the adjoining muscle as in acute myelocytic leukemia. The hyperplasia is greater in the SPLXM than in the normal mouse where splenic hyperplasia occurs in all cell lines. The rhG-CSF also results in expansion of granulopoiesis into the normally fatty tail bone marrow in SPLXM. The rhG-CSF treatment produced marked increases in the assayable numbers of GM-CFU, G-CFU and M-CFU. The significance and mechanisms of induction of these changes are not clear. It is speculated that treatment with rhG-CSF has multicellular effects, suggesting that it initiates a cascade of molecular reactions that cause the effects observed. JF - Experimental hematology AU - Cronkite, E P AU - Burlington, H AU - Shimosaka, A AU - Bullis, J E AU - Pappas, N AD - Medical Department, Brookhaven National Laboratory, Upton, NY 19973. Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 319 EP - 325 VL - 21 IS - 2 SN - 0301-472X, 0301-472X KW - Recombinant Proteins KW - 0 KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Index Medicus KW - Erythropoiesis -- drug effects KW - Animals KW - Bone Marrow -- pathology KW - Recombinant Proteins -- pharmacology KW - Dose-Response Relationship, Drug KW - Blood Platelets -- pathology KW - Temperature KW - Granulocytes -- pathology KW - Thymus Gland -- pathology KW - Spleen -- pathology KW - Mice KW - Blood Cell Count KW - Lymphocytes -- pathology KW - Mice, Inbred CBA KW - Hematopoiesis -- drug effects KW - Recombinant Proteins -- adverse effects KW - Monocytes -- pathology KW - Recombinant Proteins -- administration & dosage KW - Male KW - Splenectomy KW - Anemia -- chemically induced KW - Granulocyte Colony-Stimulating Factor -- adverse effects KW - Granulocyte Colony-Stimulating Factor -- administration & dosage KW - Anemia -- pathology KW - Granulocyte Colony-Stimulating Factor -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75582641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+hematology&rft.atitle=Anemia+induced+in+splenectomized+mice+by+administration+of+rhG-CSF.&rft.au=Cronkite%2C+E+P%3BBurlington%2C+H%3BShimosaka%2C+A%3BBullis%2C+J+E%3BPappas%2C+N&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1993-02-01&rft.volume=21&rft.issue=2&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Experimental+hematology&rft.issn=0301472X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-03-04 N1 - Date created - 1993-03-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Critical phenomena and phase transition of perovskite; data for NaMgF (sub 3) perovskite; Part II AN - 50377635; 1993-004962 AB - The crystal structure of NaMgF (sub 3) perovskite is observed to transform directly from orthorhombic (Pbnm) to cubic (Pm3m) at a temperature of T (sub c) = 765 degrees C. Superlattice diffractions associated with in-phase and anti-phase octahedral tilts vanish simultaneously at the transition temperature. The intensities of the superlattice diffractions, the atomic displacements, and the octahedral tilts follow a Landau type of critical behavior as the temperature approaches T (sub c) . The structural phase transition in NaMgF (sub 3) perovskite can be modelled as a tricritical ferroelastic phase transition. The octahedral tilts theta and phi represent the primary order parameters of the phase transition, and the coupling between these two order parameters are observed to be bi-quadratic. The spontaneous strain for the m3mFmmm ferroelastic species is derived in terms of lattice parameters and its relation to the ferroelastic species m3mF4/mmm and 4/mmmFmmm are discussed. It is demonstrated experimentally that the coupling between the spontaneous strain and the octahedral tilts of perovskites is in a linear-quadratic form. Excess physical properties (thermal expansion and heat capacity, etc.) are observed to have a lambda -anomaly during the structural phase transition in NaMgF (sub 3) perovskite, and are considered to be directly associated with the excess Gibbs free energy. JF - Physics of the Earth and Planetary Interiors AU - Zhao, Yusheng AU - Weidner, Donald J AU - Parise, John B AU - Cox, David E Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 17 EP - 34 PB - Elsevier, Amsterdam VL - 76 IS - 1-2 SN - 0031-9201, 0031-9201 KW - halides KW - fluorides KW - strain KW - crystal systems KW - mantle KW - phase transitions KW - mathematical models KW - free energy KW - crystal structure KW - neighborite KW - perovskite structure KW - orthorhombic system KW - physical properties KW - lattice parameters KW - cubic system KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50377635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+of+the+Earth+and+Planetary+Interiors&rft.atitle=Critical+phenomena+and+phase+transition+of+perovskite%3B+data+for+NaMgF+%28sub+3%29+perovskite%3B+Part+II&rft.au=Zhao%2C+Yusheng%3BWeidner%2C+Donald+J%3BParise%2C+John+B%3BCox%2C+David+E&rft.aulast=Zhao&rft.aufirst=Yusheng&rft.date=1993-02-01&rft.volume=76&rft.issue=1-2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Physics+of+the+Earth+and+Planetary+Interiors&rft.issn=00319201&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00319201 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 1993-01-01 N1 - Number of references - 39 N1 - Document feature - illus. N1 - SuppNotes - Mineral Physics Institute of SUNY at Stony Brook MPI Pub. No. 66 N1 - Last updated - 2012-06-07 N1 - CODEN - PEPIAM N1 - SubjectsTermNotLitGenreText - crystal structure; crystal systems; cubic system; fluorides; free energy; halides; lattice parameters; mantle; mathematical models; neighborite; orthorhombic system; perovskite structure; phase transitions; physical properties; strain ER - TY - JOUR T1 - Thermal expansion and structural distortion of perovskite; data for NaMgF (sub 3) perovskite; Part I AN - 50373696; 1993-004961 AB - The crystal structure of NaMgF (sub 3) perovskite (neighborite) has been studied at high temperature by X-ray powder diffraction. Data were collected using a position sensitive detector with a monochromatic synchroton radiation source. Changes in unit cell and atomic positions of the perovskite structure were defined using the Rietveld refinement technique. The linear and volumetric thermal expansion coefficients are observed to be alpha (sub a) = 4.04X10 (super -5) K (super -1) , alpha (sub b) = 1.53X10 (super -5) K (super -1) , alpha (sub c) = 3.06X10 (super -5) K (super -1) , alpha (sub v) = 8.80X10 (super -5) K (super -1) for the orthorhombic Pbnm phase, and alpha (sub a0) = 3.16X10 (super -5) K (super -1) , alpha (sub v0) = 9.49X10 (super -5) K (super -1) for the cubic Pm3m phase of NaMgF (sub 3) perovskite, respectively. The temperature-induced linear and volumetric changes of the centrosymmetrically distorted ABX (sub 3) perovskite structure can be empirically expressed as a combination of the change of the (B-X) bond length and the change of tilting of the BX (sub 6) octahedral framework. The considerable anisotropy of linear thermal expansion, alpha (sub a) >alpha (sub c) >alpha (sub b) , for the orthorhombic Pbnm phase reflects the progressive decrease of structural distortion and the development of the phase transition of the NaMgF (sub 3) perovskite. The tilting angle of the MgF (sub 6) octahedral framework is observed to decrease rapidly toward zero as the temperature approaches T (sub c) = 765 degrees C in the manner expected for a ferroelastic phase transition. More interestingly, the apparent (Mg-F) bond lengths of the MgF (sub 6) octahedra shrink dramatically throughout a temperature interval of about 100 degrees C before the phase transition. The volumetric thermal expansion increases drastically in a critical manner as the temperature approaches T (sub c) . JF - Physics of the Earth and Planetary Interiors AU - Zhao, Yusheng AU - Weidner, Donald J AU - Parise, John B AU - Cox, David E Y1 - 1993/02// PY - 1993 DA - February 1993 SP - 1 EP - 16 PB - Elsevier, Amsterdam VL - 76 IS - 1-2 SN - 0031-9201, 0031-9201 KW - halides KW - experimental studies KW - fluorides KW - expansion KW - X-ray diffraction data KW - thermal properties KW - unit cell KW - phase transitions KW - crystal structure KW - neighborite KW - perovskite structure KW - temperature KW - high temperature KW - changes KW - 17B:Geophysics of minerals and rocks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50373696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+of+the+Earth+and+Planetary+Interiors&rft.atitle=Thermal+expansion+and+structural+distortion+of+perovskite%3B+data+for+NaMgF+%28sub+3%29+perovskite%3B+Part+I&rft.au=Zhao%2C+Yusheng%3BWeidner%2C+Donald+J%3BParise%2C+John+B%3BCox%2C+David+E&rft.aulast=Zhao&rft.aufirst=Yusheng&rft.date=1993-02-01&rft.volume=76&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Physics+of+the+Earth+and+Planetary+Interiors&rft.issn=00319201&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00319201 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 1993-01-01 N1 - Number of references - 16 N1 - Document feature - illus. incl. 5 tables N1 - SuppNotes - Mineral Physics Institute of SUNY at Stony Brook MPI Pub. No. 65 N1 - Last updated - 2012-06-07 N1 - CODEN - PEPIAM N1 - SubjectsTermNotLitGenreText - changes; crystal structure; expansion; experimental studies; fluorides; halides; high temperature; neighborite; perovskite structure; phase transitions; temperature; thermal properties; unit cell; X-ray diffraction data ER - TY - JOUR T1 - Different rates of ultraviolet-induced DNA damage in the epidermis and dermis of a platyfish model for carcinogenesis. AN - 76067427; 8234656 AB - The purpose of this study was to compare fluence-response relationships for the production of cyclobutane pyrimidine dimers in epidermal or dermal DNA of platyfish Xiphophorus hybrids irradiated with UVB, and to determine photoreactivation from black light on dimers produced in situ. This was accomplished by quantitative gel electrophoresis of unlabeled DNA following extraction of the DNA and treatment with an enzyme specific for the detection of pyrimidine dimers. The dermis was the target tissue for UV-induced DNA damage in Xiphophorus hybrid fish skin. Shapes of dimer-fluence response data following filtered sunlamp irradiation (lambda > 290 nm) or monochromatic wavelength 302 nm in the epidermis or dermis were different. In the epidermis there was an initial step upward slope followed by a plateau, whereas in the dermis a linear relationship was observed. The final values of dimers at the high doses were, however, nearly equal in the epidermis and dermis exposed to either radiation. These differences in fluence-response relationships are probably attributable to the intertwining of the epidermis and to the shielding effect of the epidermal layer, with scales leading to a heterogeneous population of cells which are exposed to different UV doses. Photoreversal of dimers was readily observed by black light irradiation in both epidermis and dermis irradiated with either lambda > 290 nm or 302 nm. JF - Radiation and environmental biophysics AU - Ahmed, F E AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993 PY - 1993 DA - 1993 SP - 259 EP - 270 VL - 32 IS - 3 SN - 0301-634X, 0301-634X KW - Index Medicus KW - Animals KW - Cyprinodontiformes KW - HeLa Cells KW - Humans KW - Models, Biological KW - Ultraviolet Rays KW - Skin -- radiation effects KW - DNA Damage KW - Skin Neoplasms -- etiology KW - Melanoma, Experimental -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76067427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+and+environmental+biophysics&rft.atitle=Different+rates+of+ultraviolet-induced+DNA+damage+in+the+epidermis+and+dermis+of+a+platyfish+model+for+carcinogenesis.&rft.au=Ahmed%2C+F+E&rft.aulast=Ahmed&rft.aufirst=F&rft.date=1993-01-01&rft.volume=32&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Radiation+and+environmental+biophysics&rft.issn=0301634X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-12-20 N1 - Date created - 1993-12-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - DNA damage, photorepair, and survival in fish and human cells exposed to UV radiation. AN - 75870976; 8393402 AB - The effect of various wavelengths of UVB radiation on the induction of cyclobutane pyrimidine dimers in fish cells and human fibroblasts and the repair of these lesions were studied using an UV-endonuclease to measure dimers (endonuclease sensitive sites) by sedimentation of radioactive DNA, by gel electrophoresis of unlabeled DNA, and by cell survival. The data show that fish cells have an efficient photoreactivation system at wavelength > 304 nm that reverses cytotoxicity and dimer formation after exposure to filtered sunlamp irradiation of a shorter wavelength (lambda > 290 nm). Shorter wavelengths in UVB (> 304 nm) are more effective in photoreversal than longer ones (> 320 nm). As a consequence, 50-85% of dimers induced by these wavelengths in fish are photoreactivated while they are being formed. A major cytotoxicological lesion is the cyclobutane pyrimidine dimers. Cultured human fibroblasts do not possess such a repair system. These results indicate that sunlamp irradiation has wavelengths that both damage and repair DNA. JF - Environmental and molecular mutagenesis AU - Ahmed, F E AU - Setlow, R B AU - Grist, E AU - Setlow, N AD - Biology Department, Brookhaven National Laboratory, Upton, New York. Y1 - 1993 PY - 1993 DA - 1993 SP - 18 EP - 25 VL - 22 IS - 1 SN - 0893-6692, 0893-6692 KW - Pyrimidine Dimers KW - 0 KW - Endonucleases KW - EC 3.1.- KW - Deoxyribodipyrimidine Photo-Lyase KW - EC 4.1.99.3 KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Pyrimidine Dimers -- metabolism KW - Cells, Cultured KW - Humans KW - In Vitro Techniques KW - Dose-Response Relationship, Radiation KW - Cell Survival -- radiation effects KW - Species Specificity KW - Endonucleases -- pharmacology KW - DNA Repair KW - Deoxyribodipyrimidine Photo-Lyase -- metabolism KW - DNA Damage KW - Fishes -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75870976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=DNA+damage%2C+photorepair%2C+and+survival+in+fish+and+human+cells+exposed+to+UV+radiation.&rft.au=Ahmed%2C+F+E%3BSetlow%2C+R+B%3BGrist%2C+E%3BSetlow%2C+N&rft.aulast=Ahmed&rft.aufirst=F&rft.date=1993-01-01&rft.volume=22&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-09-02 N1 - Date created - 1993-09-02 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Functional importance of ventricular enlargement and cortical atrophy in healthy subjects and alcoholics as assessed with PET, MR imaging, and neuropsychologic testing. AN - 75528077; 8416587 AB - The authors assessed the relationship between ventricular enlargement, cortical atrophy, regional brain glucose metabolism, and neuropsychologic performance in 10 alcoholics and 10 control subjects. Regional brain glucose metabolism was measured with fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography (PET). Cortical atrophy and ventricular size were evaluated quantitatively with magnetic resonance (MR) imaging. Alcoholics had decreased brain glucose metabolism and more cortical atrophy but did not have significantly greater ventricular size than did control subjects. The degree of ventricular enlargement and of cortical atrophy was associated with decreased metabolism predominantly in the frontal cortices and subcortical structures in both alcoholics and control subjects. There were no significant correlations between neuropsychologic performance and MR imaging structural changes, whereas various subtest scores were significantly correlated with frontal lobe metabolism. These data show that F-18 FDG PET is a sensitive technique for detecting early functional changes in the brain due to alcohol and/or aging before structural changes can be detected with MR imaging. JF - Radiology AU - Wang, G J AU - Volkow, N D AU - Roque, C T AU - Cestaro, V L AU - Hitzemann, R J AU - Cantos, E L AU - Levy, A V AU - Dhawan, A P AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 59 EP - 65 VL - 186 IS - 1 SN - 0033-8419, 0033-8419 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Deoxyglucose KW - 9G2MP84A8W KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Reference Values KW - Humans KW - Glucose -- metabolism KW - Cerebral Cortex -- pathology KW - Adult KW - Deoxyglucose -- analogs & derivatives KW - Cerebral Ventricles -- pathology KW - Middle Aged KW - Atrophy KW - Cerebral Ventricles -- diagnostic imaging KW - Cerebral Cortex -- diagnostic imaging KW - Male KW - Magnetic Resonance Imaging KW - Alcoholism -- pathology KW - Alcoholism -- diagnostic imaging KW - Brain -- pathology KW - Tomography, Emission-Computed KW - Alcoholism -- metabolism KW - Brain -- metabolism KW - Neuropsychological Tests KW - Brain -- diagnostic imaging KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75528077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Functional+importance+of+ventricular+enlargement+and+cortical+atrophy+in+healthy+subjects+and+alcoholics+as+assessed+with+PET%2C+MR+imaging%2C+and+neuropsychologic+testing.&rft.au=Wang%2C+G+J%3BVolkow%2C+N+D%3BRoque%2C+C+T%3BCestaro%2C+V+L%3BHitzemann%2C+R+J%3BCantos%2C+E+L%3BLevy%2C+A+V%3BDhawan%2C+A+P&rft.aulast=Wang&rft.aufirst=G&rft.date=1993-01-01&rft.volume=186&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-21 N1 - Date created - 1993-01-21 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: Radiology. 1993 Jan;186(1):13-5 [8416553] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases. AN - 75519958; 7677974 AB - Tin-117 has certain physical characteristics (half-life of 13.6 days, low-energy-conversion electrons, gamma photon of 158.6 keV) that suggest that it may be a favorable agent for radionuclide therapy. It has been shown in animal models that Sn-117m in the chemical form Sn(4+)diethylenetriaminepentaacetic acid localizes selectively in bone. The authors therefore studied its whole-body distribution in 10 patients to obtain absorbed dose estimates for therapy. The results showed that more than 50% of the administered activity was absorbed in the bones of patients with metastatic carcinoma. Retention was determined primarily by radioactive decay. For adult men, the radiation absorbed dose estimate averaged 54.8 mGy/MBq (203 rad/mCi) to bone surfaces and 6.1 mGy/MBq (22.6 rad/mCi) to the red marrow. All other tissues received less than 1/10 of the dose received by red marrow. These results suggest that a clinical therapeutic trial should be attempted. JF - Radiology AU - Atkins, H L AU - Mausner, L F AU - Srivastava, S C AU - Meinken, G E AU - Straub, R F AU - Cabahug, C J AU - Weber, D A AU - Wong, C T AU - Sacker, D F AU - Madajewicz, S AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 279 EP - 283 VL - 186 IS - 1 SN - 0033-8419, 0033-8419 KW - Pentetic Acid KW - 7A314HQM0I KW - Abridged Index Medicus KW - Index Medicus KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Bone and Bones -- metabolism KW - Male KW - Female KW - Pain -- etiology KW - Bone Neoplasms -- physiopathology KW - Pentetic Acid -- therapeutic use KW - Pentetic Acid -- adverse effects KW - Palliative Care KW - Bone Neoplasms -- radiotherapy KW - Pentetic Acid -- pharmacokinetics KW - Bone Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75519958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Biodistribution+of+Sn-117m%284%2B%29DTPA+for+palliative+therapy+of+painful+osseous+metastases.&rft.au=Atkins%2C+H+L%3BMausner%2C+L+F%3BSrivastava%2C+S+C%3BMeinken%2C+G+E%3BStraub%2C+R+F%3BCabahug%2C+C+J%3BWeber%2C+D+A%3BWong%2C+C+T%3BSacker%2C+D+F%3BMadajewicz%2C+S&rft.aulast=Atkins&rft.aufirst=H&rft.date=1993-01-01&rft.volume=186&rft.issue=1&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-21 N1 - Date created - 1993-01-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - BOOK T1 - Enhancement of the signal to noise ratio in functional-anatomical brain patterns obtained by multiple PET to anatomical atlas registration: sensitivity analysis to missing data AN - 744635539; 107803 AB - We review the function-of-interest method, which is a fast accurate computer method, capable of automatically detecting faint 3-dimensional whole-brain functional patterns in groups of PET metabolic brain images and by projecting them into a brain atlas in order to identify the anatomical structures that support them. A sensitivity analysis of the method is done with respect to missing data, frequently caused by the PET camera's limited field of view. JF - IEEE, PISCATAWAY, NJ, (USA). no. 16-117. 1993. AU - Levy, A V AU - Alexoff, D L AU - Bertollo, D N Y1 - 1993 PY - 1993 DA - 1993 PB - IEEE, PISCATAWAY, NJ, (USA) SN - 0780313771 KW - Computerized tomography KW - Function-of-interest method KW - Medical imaging KW - Optimization KW - PET brain images KW - Positron emission tomography KW - Sensitivity analysis KW - Signal filtering and prediction KW - Signal to noise ratio KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - W4 723.2:DATA PROCESSING KW - W4 461.1:BIOMEDICAL ENGINEERING KW - W 30965:Miscellaneous, Reviews KW - W4 716.3:RADIO SYSTEMS AND EQUIPMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744635539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Biotechnology+Research+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Levy%2C+A+V%3BAlexoff%2C+D+L%3BBertollo%2C+D+N&rft.aulast=Levy&rft.aufirst=A&rft.date=1993-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0780313771&rft.btitle=Enhancement+of+the+signal+to+noise+ratio+in+functional-anatomical+brain+patterns+obtained+by+multiple+PET+to+anatomical+atlas+registration%3A+sensitivity+analysis+to+missing+data&rft.title=Enhancement+of+the+signal+to+noise+ratio+in+functional-anatomical+brain+patterns+obtained+by+multiple+PET+to+anatomical+atlas+registration%3A+sensitivity+analysis+to+missing+data&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Tritium and radiocarbon dating of Canada Basin deep waters AN - 52712987; 1997-045095 JF - Science AU - Macdonald, R W AU - Carmack, E C AU - Wallace, D W R Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 103 EP - 104 PB - American Association for the Advancement of Science, Washington, DC VL - 259 IS - 5091 SN - 0036-8075, 0036-8075 KW - organic materials KW - sea water KW - isotopes KW - tritium KW - deep-sea environment KW - Canada Basin KW - theoretical studies KW - organic compounds KW - radioactive isotopes KW - dates KW - marine environment KW - hydrogen KW - carbon KW - absolute age KW - Arctic Ocean KW - C-14 KW - organic carbon KW - nitrate ion KW - 03:Geochronology KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52712987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=Tritium+and+radiocarbon+dating+of+Canada+Basin+deep+waters&rft.au=Macdonald%2C+R+W%3BCarmack%2C+E+C%3BWallace%2C+D+W+R&rft.aulast=Macdonald&rft.aufirst=R&rft.date=1993-01-01&rft.volume=259&rft.issue=5091&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 11 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - SCIEAS N1 - SubjectsTermNotLitGenreText - absolute age; Arctic Ocean; C-14; Canada Basin; carbon; dates; deep-sea environment; hydrogen; isotopes; marine environment; nitrate ion; organic carbon; organic compounds; organic materials; radioactive isotopes; sea water; theoretical studies; tritium ER - TY - JOUR T1 - Reduced chromium in olivine grains from lunar basalt 15555; X-ray absorption near edge structure (XANES) AN - 50377206; 1993-002738 AB - Using XANES, the oxidation state of Cr in 200 mu m regions within lunar olivine and pyroxene grains from this basalt was determined. The results suggest that Cr in lunar olivine is mainly divalent whereas Cr in the lunar pyroxene is mainly trivalent. It is suggested also that the mare magma source originally contained Cr (super 2+) and Cr (super 3+) and these were preferentially incorporated into olivine and pyroxene respectively. The melt was perhaps dominated by Cr (super 2+) at the time of olivine crystallization. JF - Geochimica et Cosmochimica Acta AU - Sutton, S R AU - Jones, K W AU - Gordon, B AU - Rivers, M L AU - Bajt, S AU - Smith, J V Y1 - 1993/01// PY - 1993 DA - January 1993 SP - 461 EP - 468 PB - Pergamon, Oxford VL - 57 IS - 2 SN - 0016-7037, 0016-7037 KW - silicates KW - X-ray absorption data KW - volcanic rocks KW - Moon KW - igneous rocks KW - optical spectra KW - olivine group KW - fugacity KW - nesosilicates KW - absorption KW - pyroxene group KW - metals KW - olivine KW - basalts KW - orthosilicates KW - spectra KW - chromium KW - chain silicates KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50377206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Reduced+chromium+in+olivine+grains+from+lunar+basalt+15555%3B+X-ray+absorption+near+edge+structure+%28XANES%29&rft.au=Sutton%2C+S+R%3BJones%2C+K+W%3BGordon%2C+B%3BRivers%2C+M+L%3BBajt%2C+S%3BSmith%2C+J+V&rft.aulast=Sutton&rft.aufirst=S&rft.date=1993-01-01&rft.volume=57&rft.issue=2&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2F0016-7037%2893%2990444-2 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 1993-01-01 N1 - Number of references - 29 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - absorption; basalts; chain silicates; chromium; fugacity; igneous rocks; metals; Moon; nesosilicates; olivine; olivine group; optical spectra; orthosilicates; pyroxene group; silicates; spectra; volcanic rocks; X-ray absorption data DO - http://dx.doi.org/10.1016/0016-7037(93)90444-2 ER - TY - JOUR T1 - SXRF determination of trace elements in chondrule rims in the unequilibrated CO (sub 3) chondrite, ALH A77307 AN - 50364870; 1993-011139 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Brearley, Adrian J AU - Bajt, Sasa AU - Sutton, Steve R AU - Blanchard, Douglas AU - Black, David Y1 - 1993 PY - 1993 DA - 1993 SP - 187 EP - 188 PB - Lunar and Planetary Science Conference, Houston, TX VL - 24 KW - zinc KW - gallium KW - stony meteorites KW - selenium KW - copper KW - carbonaceous chondrites KW - thin sections KW - electron probe data KW - CO chondrites KW - meteorites KW - Allan Hills Meteorites KW - metals KW - chondrules KW - germanium KW - nickel KW - ALHA 77307 KW - X-ray fluorescence spectra KW - spectra KW - trace elements KW - chondrites KW - 05B:Petrology of meteorites and tektites KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50364870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=SXRF+determination+of+trace+elements+in+chondrule+rims+in+the+unequilibrated+CO+%28sub+3%29+chondrite%2C+ALH+A77307&rft.au=Brearley%2C+Adrian+J%3BBajt%2C+Sasa%3BSutton%2C+Steve+R%3BBlanchard%2C+Douglas%3BBlack%2C+David&rft.aulast=Brearley&rft.aufirst=Adrian&rft.date=1993-01-01&rft.volume=24&rft.issue=&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-fourth lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - PubXState - TX N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - ALHA 77307; Allan Hills Meteorites; carbonaceous chondrites; chondrites; chondrules; CO chondrites; copper; electron probe data; gallium; germanium; metals; meteorites; nickel; selenium; spectra; stony meteorites; thin sections; trace elements; X-ray fluorescence spectra; zinc ER - TY - JOUR T1 - Wavelength dispersive analysis with the synchrotron X-ray fluorescence microprobe AN - 50350189; 1993-018911 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Rivers, M L AU - Thorn, K S AU - Sutton, S R AU - Jones, K W AU - Bajt, S AU - Blanchard, Douglas AU - Black, David Y1 - 1993 PY - 1993 DA - 1993 SP - 1203 EP - 1204 PB - Lunar and Planetary Science Conference, Houston, TX VL - 24 KW - volcanic rocks KW - glasses KW - metals KW - igneous rocks KW - standard materials KW - X-ray fluorescence spectra KW - synchrotrons KW - alloys KW - spectra KW - rare earths KW - kamacite KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50350189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Wavelength+dispersive+analysis+with+the+synchrotron+X-ray+fluorescence+microprobe&rft.au=Rivers%2C+M+L%3BThorn%2C+K+S%3BSutton%2C+S+R%3BJones%2C+K+W%3BBajt%2C+S%3BBlanchard%2C+Douglas%3BBlack%2C+David&rft.aulast=Rivers&rft.aufirst=M&rft.date=1993-01-01&rft.volume=24&rft.issue=&rft.spage=1203&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-fourth lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 3 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - alloys; glasses; igneous rocks; kamacite; metals; rare earths; spectra; standard materials; synchrotrons; volcanic rocks; X-ray fluorescence spectra ER - TY - JOUR T1 - Neutron diffraction studies of the P[unk] --> I[unk] transition in anorthite, CaAl (sub 2) Si (sub 2) O (sub 8) , and the crystal structure of the body-centered phase at 514 K AN - 1840614763; 2016-097246 AB - The crystal structure of anorthite, CaAl (sub 2) Si (sub 2) O (sub 8) (Val di Fassa, Monzoni, Italy, An, 100%) has been refined by full-matrix least-squares methods using single-crystal neutron diffraction data (sintheta /lambda < or = 0.78 Aa (super -1) ) measured at 514 K. Crystal data: triclinic, space group I[unk] (assumed), Z = 8, a = 8.194(1), b = 12.878(4), c = 14.171(6) Aa; alpha = 93.07(2), beta = 115.07(2), gamma = 91.47(2) degrees , V = 1343.6 Aa (super 3) , mu (sub n) = 4.2 X 10 (super -3) cm (super -1) F(000) = 532.16 fm, lambda = 1.0462(1) Aa. R(F (super 2) ) = 0.049, wR(F (super 2) ) = 0.068, S = 1.27 for 5098 reflections and 293 parameters, including 40 third-order thermal tensor coefficients for four oxygen atoms. The aluminosilicate framework is virtually body-centered, whereas the Ca atoms occur in split-positions with unequal site occupancies. The eight tetrahedral sites show complete Al/Si ordering based on refined scattering-lengths values. The 16 distinct Si-O and [Al-O] bonds (e.s.d.'s, 0.001 Aa) have average values of 1.617 + or - 0.031 Aa and [1.741 + or - 0.029 Aa]. The O-Si-O and [O-Al-O] angles are in the ranges 101.44(6) - 117.60(7) degrees and [97.87(7)-119.01(7) degrees ] and have averages of 109.42 and [109.31 degrees ]. The unique Si-O-Al angles are between extremes 124.16(6) and 154.7(2) degrees . The two non-equivalent Ca atoms occupy statistically two sites with respective separations, 0.834(5), 0.494(5) Aa, and weights equal 2/3, 1/3 within limits of the analysis. These results are interpreted in terms of a dynamical model in which the I[unk] phase is a statistical dynamical average of small mobile P[unk] domains. The unequal Ca occupancy in the split positions results from the persistence of considerable short-range order near T (sub c) . Significant anharmonic thermal vibrations of some of the oxygen atoms are attributed to critical fluctuations associated with the phase transition near T (sub c) . JF - Zeitschrift fuer Kristallographie AU - Ghose, Subrata AU - McMullan, R K AU - Weber, H P Y1 - 1993 PY - 1993 DA - 1993 SP - 215 EP - 237 PB - De Gruyter for Oldenbourg, Munich VL - 204 IS - Part 2 SN - 0044-2968, 0044-2968 KW - silicates KW - plagioclase KW - experimental studies KW - refinement KW - space groups KW - phase transitions KW - crystal structure KW - temperature KW - anorthite KW - laboratory studies KW - neutron diffraction data KW - framework silicates KW - lattice parameters KW - feldspar group KW - high temperature KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1840614763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zeitschrift+fuer+Kristallographie&rft.atitle=Neutron+diffraction+studies+of+the+P%5Bunk%5D+--%26gt%3B+I%5Bunk%5D+transition+in+anorthite%2C+CaAl+%28sub+2%29+Si+%28sub+2%29+O+%28sub+8%29+%2C+and+the+crystal+structure+of+the+body-centered+phase+at+514+K&rft.au=Ghose%2C+Subrata%3BMcMullan%2C+R+K%3BWeber%2C+H+P&rft.aulast=Ghose&rft.aufirst=Subrata&rft.date=1993-01-01&rft.volume=204&rft.issue=Part+2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Zeitschrift+fuer+Kristallographie&rft.issn=00442968&rft_id=info:doi/10.1524%2Fzkri.1993.204.Part-2.215 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by Walter de Gruyter GmbH, Berlin, Germany N1 - Date revised - 2016-01-01 N1 - Number of references - 44 N1 - Document feature - illus. incl. 5 tables N1 - SuppNotes - Includes appendices N1 - Last updated - 2016-11-17 N1 - SubjectsTermNotLitGenreText - anorthite; crystal structure; experimental studies; feldspar group; framework silicates; high temperature; laboratory studies; lattice parameters; neutron diffraction data; phase transitions; plagioclase; refinement; silicates; space groups; temperature DO - http://dx.doi.org/10.1524/zkri.1993.204.Part-2.215 ER - TY - BOOK T1 - Field testing of waste forms using lysimeters; results after seven years AN - 1464887438; 2013-089202 JF - Geoconfine 93 AU - Rogers, R D AU - McConnell, J W, Jr AU - Sullivan, T M AU - Jastrow, J D AU - Hicks, D S Y1 - 1993 PY - 1993 DA - 1993 PB - A. A. Balkema, Rotterdam SN - 9054103310 KW - United States KW - Three Mile Island Nuclear Power Station KW - soils KW - toxic materials KW - contaminant plumes KW - engineering properties KW - regulations KW - waste disposal sites KW - pollution KW - seepage KW - Dauphin County Pennsylvania KW - radioactive waste KW - Low-Level Waste Data Base Development Program KW - data bases KW - testing KW - risk assessment KW - waste disposal KW - Pennsylvania KW - lysimeters KW - low-level waste KW - Middletown Pennsylvania KW - construction materials KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1464887438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Rogers%2C+R+D%3BMcConnell%2C+J+W%2C+Jr%3BSullivan%2C+T+M%3BJastrow%2C+J+D%3BHicks%2C+D+S&rft.aulast=Rogers&rft.aufirst=R&rft.date=1993-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=9054103310&rft.btitle=Field+testing+of+waste+forms+using+lysimeters%3B+results+after+seven+years&rft.title=Field+testing+of+waste+forms+using+lysimeters%3B+results+after+seven+years&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geoconfine 93 N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2013-01-01 N1 - Number of references - 17 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2013-12-05 ER - TY - JOUR T1 - Estimating the growth rate of slowly growing marine bacteria from RNA content AN - 13678540; S199648492 AB - The feasibility of using measurements of RNA content as indicators of bacterial growth rate was investigated in the case of slowly-growing bacteria. Previous studies had suggested a correlation in the case of a few bacterial taxa, but these might not be relevant to the case of marine bacteria which were often exposed to environments low in nutrients. Chemostat cultures of marine bacterial isolates in which growth rates could be measured accurately for comparison with various measures of RNA content were used. The results suggested that cellular RNA content was likely to be useful predictor of growth rate for slowly-growing marine bacteria, particularly when applied at the level of individual species. JF - Applied and Environmental Microbiology AU - Kemp, P F AU - Lee, S AU - LaRoche, J AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1993 PY - 1993 DA - 1993 SP - 2594 EP - 2601 VL - 59 IS - 8 SN - 0099-2240, 0099-2240 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13678540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Estimating+the+growth+rate+of+slowly+growing+marine+bacteria+from+RNA+content&rft.au=Kemp%2C+P+F%3BLee%2C+S%3BLaRoche%2C+J&rft.aulast=Kemp&rft.aufirst=P&rft.date=1993-01-01&rft.volume=59&rft.issue=8&rft.spage=2594&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Physical oceanography of the Gulf, strait of Hormuz, and the gulf of Oman - results from the Mt Mitchell expedition AN - 13673719; S199750081 AB - Results are summarized of the oceanographic measurements in the Arabian gulf and associated waterways carried out by the survey vessel Mt Mitchell between February and June 1992. The surveys involved conductivity/temperature/depth measurements, the use of current meters and drift buoys and continuous shipboard measurements of meteorological and oceanographic variables. The accuracy and precision of the data and quality assurance of the measurements are discussed. The data covered the important seasonal transition from mid-winter to early summer. During this period, solar heating created an intense thermocline. There are 34 references. JF - Marine Pollution Bulletin AU - Reynolds, R M AD - Brookhaven National Laboratory, Upton, N.Y., U.S.A. Y1 - 1993 PY - 1993 DA - 1993 SP - 35 EP - 59 VL - 27 SN - 0025-326X, 0025-326X KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13673719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Pollution+Bulletin&rft.atitle=Physical+oceanography+of+the+Gulf%2C+strait+of+Hormuz%2C+and+the+gulf+of+Oman+-+results+from+the+Mt+Mitchell+expedition&rft.au=Reynolds%2C+R+M&rft.aulast=Reynolds&rft.aufirst=R&rft.date=1993-01-01&rft.volume=27&rft.issue=&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Marine+Pollution+Bulletin&rft.issn=0025326X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Case Study. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Coulometric total carbon dioxide analysis for marine studies: maximizing the performance of an automated gas extraction system and coulometric detector AN - 13667304; S199851027 AB - An automated gas extraction analyser system was modified and developed for the measurement of dissolved carbon dioxide in seawater. Following prototype development between 1987 and 1990, the instrument, known as a single-operator multiparameter metabolic analyser (SOMMA), combined functional and operating procedures including integrated electronic calibration, carbon dioxide gas calibration, and sample analysis with automated pressure, temperature and conductivity (salinity) sensing in a single convenient transportable package. The analytical method for total carbon dioxide was gas extraction of acidified seawater with colorimetric titration of the acid formed by the resultant carbon dioxide and monoethanolamine. This analytical system would be used as part of the World Ocean Circulation Experiments - World Hydrographic Programme (WOCE-WHP) to be carried out in 1995 involving a global survey of the distribution of dissolved carbon dioxide, with a view to the development of a data base from which future fossil fuel carbon dioxide build-up could be monitored. This automated SOMMA system combined high accuracy and precision (plus or minus 1.5 umol per Kg for total carbon dioxide greater than or equal to 2000 umol per kg) with a high rate of analysis. JF - Marine Chemistry AU - Johnson, K M AU - Wills, K D AU - Butler, D B AU - Johnson, W K AU - Wong, C S AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1993 PY - 1993 DA - 1993 SP - 167 EP - 187 VL - 44 IS - 2/4 SN - 0304-4203, 0304-4203 KW - Analysis KW - Instrumentation KW - Sea water (see also marine -----) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13667304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Chemistry&rft.atitle=Coulometric+total+carbon+dioxide+analysis+for+marine+studies%3A+maximizing+the+performance+of+an+automated+gas+extraction+system+and+coulometric+detector&rft.au=Johnson%2C+K+M%3BWills%2C+K+D%3BButler%2C+D+B%3BJohnson%2C+W+K%3BWong%2C+C+S&rft.aulast=Johnson&rft.aufirst=K&rft.date=1993-01-01&rft.volume=44&rft.issue=2%2F4&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Marine+Chemistry&rft.issn=03044203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Comparative PET studies of the kinetics and distribution of cocaine and cocaethylene in baboon brain. AN - 73433476; 1481141 AB - Recent studies have suggested that cocaethylene, an active metabolite of cocaine found in blood and postmortem brain of individuals self-administering cocaine and alcohol, may play a role in the increased toxicity seen when coadministering these 2 drugs. We have used positron emission tomography (PET) and carbon-11 (t1/2:20.4 min) labeled cocaine and cocaethylene to compare the short-term kinetics of cocaine and cocaethylene in baboon brain. The regional uptake of [11C]cocaine cocaethylene in baboon brain. The regional uptake of [11C]cocaine ([11C]COC) and [11C]cocaethylene ([11C]CE), 5-8 mCi and 4-6 micrograms, in baboon brain (n = 7) were similar but clearance from whole brain (global, GL) and from striatum (SR), thalamus (TH), and cerebellum (CB) was slower for cocaethylene. Steady-state distribution volumes (DV) were not significantly different in the striatum but were greater for cocaethylene in the thalamus, cerebellum, and whole brain. Debenzoylation of cocaethylene proceeded at about one-third the rate of cocaine, as determined by in vitro incubation of labeled cocaethylene and labeled cocaine with baboon plasma and with purified horse butyryl-cholinesterase (EC 3.1.1.8). Even though the slower clearance of cocaethylene could lead to longer tissue exposures and potentially accentuated or different physiological effects relative to cocaine, the difference between the 2 drugs is not large. Thus it is more likely that the direct actions of cocaine and alcohol on some organs, rather than cocaethylene, account for this enhanced toxicity. JF - Synapse (New York, N.Y.) AU - Fowler, J S AU - Volkow, N D AU - MacGregor, R R AU - Logan, J AU - Dewey, S L AU - Gatley, S J AU - Wolf, A P AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 220 EP - 227 VL - 12 IS - 3 SN - 0887-4476, 0887-4476 KW - cocaethylene KW - FJO3071W5Y KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Papio KW - Animals KW - Kinetics KW - Tissue Distribution KW - Time Factors KW - Female KW - Cocaine -- analogs & derivatives KW - Tomography, Emission-Computed KW - Cocaine -- pharmacokinetics KW - Brain -- metabolism KW - Cocaine -- blood KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73433476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Comparative+PET+studies+of+the+kinetics+and+distribution+of+cocaine+and+cocaethylene+in+baboon+brain.&rft.au=Fowler%2C+J+S%3BVolkow%2C+N+D%3BMacGregor%2C+R+R%3BLogan%2C+J%3BDewey%2C+S+L%3BGatley%2C+S+J%3BWolf%2C+A+P&rft.aulast=Fowler&rft.aufirst=J&rft.date=1992-11-01&rft.volume=12&rft.issue=3&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-11 N1 - Date created - 1993-02-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Alcohol intoxication does not change [11C]cocaine pharmacokinetics in human brain and heart. AN - 73432100; 1481142 AB - There is increasing evidence that the combined use of cocaine and alcohol produces enhanced behavioral and toxic effects. We have used PET and tracer doses of [11C]cocaine in 7 normal human volunteers to assess if the distribution and clearance of cocaine are altered by alcohol intoxication. Each subject received 2 PET studies with [11C]cocaine (3-11 micrograms), one before and one during alcohol intoxication (1 g/kg). Regions of interest included the brain (n = 3) and heart (n = 4). Arterial plasma was assayed for unchanged cocaine and for labeled cocaethylene, a metabolite of cocaine found in individuals using cocaine and alcohol in combination (Hearn et al., 1991a). Alcohol intoxication did not change uptake and clearance or the steady-state distribution volume of [11C] cocaine in brain (striatum, thalamus, and cerebellum) or in heart. Moreover, labeled cocaethylene was not detected in the 10 minute plasma sample. These results suggest that the acute enhancement of behavior and toxicity associated with the combined use of cocaine and alcohol is not due to an alteration in cocaine's organ distribution or to cocaethylene formation but may be related to an additive effect resulting from the direct actions of each of these drugs. JF - Synapse (New York, N.Y.) AU - Fowler, J S AU - Volkow, N D AU - Logan, J AU - MacGregor, R R AU - Wang, G J AU - Wolf, A P AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 228 EP - 235 VL - 12 IS - 3 SN - 0887-4476, 0887-4476 KW - Carbon Radioisotopes KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Heart -- diagnostic imaging KW - Humans KW - Adult KW - Tomography, Emission-Computed KW - Aged KW - Middle Aged KW - Time Factors KW - Chromatography, High Pressure Liquid KW - Alcoholic Intoxication -- blood KW - Cocaine -- pharmacokinetics KW - Brain -- metabolism KW - Brain -- diagnostic imaging KW - Myocardium -- metabolism KW - Alcoholic Intoxication -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73432100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Alcohol+intoxication+does+not+change+%5B11C%5Dcocaine+pharmacokinetics+in+human+brain+and+heart.&rft.au=Fowler%2C+J+S%3BVolkow%2C+N+D%3BLogan%2C+J%3BMacGregor%2C+R+R%3BWang%2C+G+J%3BWolf%2C+A+P&rft.aulast=Fowler&rft.aufirst=J&rft.date=1992-11-01&rft.volume=12&rft.issue=3&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-02-11 N1 - Date created - 1993-02-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Ion chromatographic analysis of high specific activity 18FDG preparations and detection of the chemical impurity 2-deoxy-2-chloro-D-glucose. AN - 73398269; 1333458 AB - Because of the widespread use of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) prepared by the "Julich" method or its variants it was decided necessary to determine the major chemical impurities present in the final product. An analytical system for quantifying FDG was developed using pulsed amperometry after separation by high-performance anion exchange chromatography. With this system a heretofore unidentified impurity, 2-deoxy-2-chloro-D-glucose (C1DG, ca 20-2000 micrograms; typically < 100 micrograms), was found in our preparation and in those from other laboratories using the "Julich" method. C1DG arises from Cl- ion displacement during the labeling procedure where Cl- ion comes from several sources, and Cl- ion displacement from the HCl used in the hydrolysis step. FDG mass was present in the same preparations at a level of ca 1-40 micrograms. Other major chemical constituents were glucose (ca 1-6 mg) and mannose (ca 10-18 micrograms). Glycerol, arising from sterilizing filters, was also detected in most preparations. Although C1DG is a chemical impurity which has not been detected previously in nca FDG preparations, its biochemical and pharmacological properties are similar to FDG and 2-deoxy-D-glucose. Thus it is unlikely that the presence of small quantities of C1DG found in typical FDG preparations (ca 100 micrograms) would have adverse pharmacological or toxicological consequences that would limit continued application of this radiopharmaceutical in basic and clinical studies. JF - International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes AU - Alexoff, D L AU - Casati, R AU - Fowler, J S AU - Wolf, A P AU - Shea, C AU - Schlyer, D J AU - Shiue, C Y AD - Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 1313 EP - 1322 VL - 43 IS - 11 SN - 0883-2889, 0883-2889 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - 2-chloro-2-deoxyglucose KW - 14685-79-1 KW - Deoxyglucose KW - 9G2MP84A8W KW - Index Medicus KW - Chromatography, Ion Exchange KW - Deoxyglucose -- analysis KW - Deoxyglucose -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73398269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+applications+and+instrumentation.+Part+A%2C+Applied+radiation+and+isotopes&rft.atitle=Ion+chromatographic+analysis+of+high+specific+activity+18FDG+preparations+and+detection+of+the+chemical+impurity+2-deoxy-2-chloro-D-glucose.&rft.au=Alexoff%2C+D+L%3BCasati%2C+R%3BFowler%2C+J+S%3BWolf%2C+A+P%3BShea%2C+C%3BSchlyer%2C+D+J%3BShiue%2C+C+Y&rft.aulast=Alexoff&rft.aufirst=D&rft.date=1992-11-01&rft.volume=43&rft.issue=11&rft.spage=1313&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+applications+and+instrumentation.+Part+A%2C+Applied+radiation+and+isotopes&rft.issn=08832889&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-01-04 N1 - Date created - 1993-01-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - X-ray fluorescence microanalysis and imaging AN - 52762523; 1997-009865 JF - Agronomy Abstracts AU - Sutton, S R AU - Rivers, M L AU - Bajt, S AU - Jones, K AU - Anonymous Y1 - 1992/11// PY - 1992 DA - November 1992 SP - 380 EP - 381 PB - American Society of Agronomy, Madison, WI VL - 84 SN - 0375-5495, 0375-5495 KW - synchrotron radiation KW - methods KW - chemical analysis KW - X-ray fluorescence KW - X-ray analysis KW - instruments KW - 01A:General mineralogy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52762523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agronomy+Abstracts&rft.atitle=X-ray+fluorescence+microanalysis+and+imaging&rft.au=Sutton%2C+S+R%3BRivers%2C+M+L%3BBajt%2C+S%3BJones%2C+K%3BAnonymous&rft.aulast=Sutton&rft.aufirst=S&rft.date=1992-11-01&rft.volume=84&rft.issue=&rft.spage=380&rft.isbn=&rft.btitle=&rft.title=Agronomy+Abstracts&rft.issn=03755495&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 1992 annual meetings; American Society of Agronomy, 84th annual meeting; Crop Science Society of America; Soil Science Society of America; Clay Minerals Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - WI N1 - Last updated - 2012-06-07 N1 - CODEN - AGABBE N1 - SubjectsTermNotLitGenreText - chemical analysis; instruments; methods; synchrotron radiation; X-ray analysis; X-ray fluorescence ER - TY - JOUR T1 - Neuropsychiatric disorders: investigation of schizophrenia and substance abuse. AN - 73336341; 1439871 AB - Because neuropsychiatric disorders involve functional and neurochemical cerebral abnormalities, positron emission tomography (PET) is ideally suited for their investigation. The use of tracers to measure regional brain glucose metabolism and/or blood flow has allowed the evaluation of brain function in psychiatric patients. The use of radioligands to assess receptor concentration has enabled an evaluation of the extent to which specific neurotransmitter systems are involved in the pathogenesis of mental illness. This article reviews the application of PET technology to the understanding of schizophrenic disorders and substance abuse. JF - Seminars in nuclear medicine AU - Volkow, N D AU - Fowler, J S AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1992/10// PY - 1992 DA - October 1992 SP - 254 EP - 267 VL - 22 IS - 4 SN - 0001-2998, 0001-2998 KW - Index Medicus KW - Mental Disorders -- diagnostic imaging KW - Humans KW - Brain Diseases -- diagnostic imaging KW - Schizophrenia -- diagnostic imaging KW - Tomography, Emission-Computed KW - Substance-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73336341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+nuclear+medicine&rft.atitle=Neuropsychiatric+disorders%3A+investigation+of+schizophrenia+and+substance+abuse.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S&rft.aulast=Volkow&rft.aufirst=N&rft.date=1992-10-01&rft.volume=22&rft.issue=4&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Seminars+in+nuclear+medicine&rft.issn=00012998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-12-03 N1 - Date created - 1992-12-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Toxic metal oxidation states in low-level radioactive wasteforms; initial chromium XANES results AN - 52792528; 1996-080097 JF - Eos, Transactions, American Geophysical Union AU - Bajt, S AU - Sutton, S R AU - Rivers, M L AU - Smith, J V AU - Clark, S B AU - Hunter, D AU - Bertsch, P AU - Langton, C A AU - Jones, K W AU - Anonymous Y1 - 1992/10// PY - 1992 DA - October 1992 SP - 157 PB - American Geophysical Union, Washington, DC VL - 73 IS - 43, Suppl. SN - 0096-3941, 0096-3941 KW - toxicity KW - metals KW - oxidation KW - XANES KW - waste disposal KW - leaching KW - interpretation KW - low-level waste KW - chromium KW - radioactive waste KW - ground water KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52792528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Toxic+metal+oxidation+states+in+low-level+radioactive+wasteforms%3B+initial+chromium+XANES+results&rft.au=Bajt%2C+S%3BSutton%2C+S+R%3BRivers%2C+M+L%3BSmith%2C+J+V%3BClark%2C+S+B%3BHunter%2C+D%3BBertsch%2C+P%3BLangton%2C+C+A%3BJones%2C+K+W%3BAnonymous&rft.aulast=Bajt&rft.aufirst=S&rft.date=1992-10-01&rft.volume=73&rft.issue=43%2C+Suppl.&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union, 1992 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - chromium; ground water; interpretation; leaching; low-level waste; metals; oxidation; radioactive waste; toxicity; waste disposal; XANES ER - TY - JOUR T1 - Halocarbon ratio and tritium/ (super 3) He dating of water masses in the Nansen Basin, Arctic Ocean AN - 52800044; 1996-073536 JF - Deep-Sea Research. Part A: Oceanographic Research Papers AU - Wallace, D W R AU - Schlosser, P AU - Krysell, M AU - Boenisch, G A2 - Pfirman, S. L. A2 - Thiede, J. Y1 - 1992/09// PY - 1992 DA - September 1992 SP - 435 EP - 458 PB - Pergamon, Oxford-New York VL - 39 IS - Suppl. 2A SN - 0198-0149, 0198-0149 KW - ocean circulation KW - sea water KW - isotopes KW - human activity KW - atmosphere KW - tritium KW - He-3 KW - stable isotopes KW - organic compounds KW - radioactive isotopes KW - noble gases KW - hydrogen KW - age KW - tracers KW - absolute age KW - halogenated hydrocarbons KW - Arctic Ocean KW - Nansen Basin KW - helium KW - 02D:Isotope geochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52800044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+A%3A+Oceanographic+Research+Papers&rft.atitle=Halocarbon+ratio+and+tritium%2F+%28super+3%29+He+dating+of+water+masses+in+the+Nansen+Basin%2C+Arctic+Ocean&rft.au=Wallace%2C+D+W+R%3BSchlosser%2C+P%3BKrysell%2C+M%3BBoenisch%2C+G&rft.aulast=Wallace&rft.aufirst=D+W&rft.date=1992-09-01&rft.volume=39&rft.issue=Suppl.+2A&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+A%3A+Oceanographic+Research+Papers&rft.issn=01980149&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 39 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - DRPPD5 N1 - SubjectsTermNotLitGenreText - absolute age; age; Arctic Ocean; atmosphere; halogenated hydrocarbons; He-3; helium; human activity; hydrogen; isotopes; Nansen Basin; noble gases; ocean circulation; organic compounds; radioactive isotopes; sea water; stable isotopes; tracers; tritium ER - TY - JOUR T1 - Use of fluidizing bed aerosol generators to establish a dust mixture of two substances at a fixed ratio for inhalation toxicity studies. AN - 73150336; 1509991 AB - A method was developed to use two fluidizing bed generators to deliver a mixture of 1 mg cobalt + 15 mg tungsten carbide/m3 to an inhalation exposure chamber with the output from the cobalt generator split to provide the same cobalt concentration to a cobalt-only chamber. To provide a more uniform delivery of material and to minimize the amount of starting dust needed, a subsystem that produced timed bursts of compressed air was used to prevent the accumulation of dust along the aerosol transport tubes. The addition of an electrostatic precipitator placed in the exhaust lines reduced the amount of dust delivered to the high-efficiency particulate air filters, thereby reducing the number of filter changes. JF - American Industrial Hygiene Association journal AU - Shiotsuka, R N AU - Kutzman, R S AU - Firriolo, J M AU - Drew, R T AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 510 EP - 513 VL - 53 IS - 8 SN - 0002-8894, 0002-8894 KW - Aerosols KW - 0 KW - Tungsten Compounds KW - tungsten carbide KW - 11130-73-7 KW - Cobalt KW - 3G0H8C9362 KW - Tungsten KW - V9306CXO6G KW - Index Medicus KW - Air Pollution -- prevention & control KW - Humans KW - Bronchial Provocation Tests KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73150336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Industrial+Hygiene+Association+journal&rft.atitle=Use+of+fluidizing+bed+aerosol+generators+to+establish+a+dust+mixture+of+two+substances+at+a+fixed+ratio+for+inhalation+toxicity+studies.&rft.au=Shiotsuka%2C+R+N%3BKutzman%2C+R+S%3BFirriolo%2C+J+M%3BDrew%2C+R+T&rft.aulast=Shiotsuka&rft.aufirst=R&rft.date=1992-08-01&rft.volume=53&rft.issue=8&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=American+Industrial+Hygiene+Association+journal&rft.issn=00028894&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-09-21 N1 - Date created - 1992-09-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Decreased brain metabolism in neurologically intact healthy alcoholics. AN - 73092948; 1636801 AB - OBJECTIVEThe extent to which cerebral dysfunction in alcoholics is related to the direct effects of alcohol in the brain rather than to indirect mechanisms and/or alcohol withdrawal remains unclear. The purpose of this study was to evaluate whether healthy alcoholics with no evidence of alcohol-associated complications showed changes in brain glucose metabolism.METHODPositron emission tomography and [18F]-fluorodeoxyglucose were used to measure regional brain metabolism. The study group consisted of 22 normal, healthy, right-handed volunteers and 22 neurologically intact, healthy, right-handed alcoholics tested 6 to 32 days after alcohol discontinuation.RESULTSAlcoholics showed significantly lower whole brain metabolism than normal control subjects. Normalization of regional metabolic values to the whole brain metabolic rate revealed that the left parietal and right frontal cortices were the most affected regions. Although the whole brain metabolic rate was correlated with the amount of time since alcohol discontinuation, the "normalized" decreases in left parietal and right frontal glucose metabolism were not.CONCLUSIONSThese findings support the contribution of the direct effect of alcohol as well as alcohol withdrawal on the changes in regional brain metabolism seen in alcoholics. They also provide evidence of cerebral changes in neurologically intact healthy alcoholics. JF - The American journal of psychiatry AU - Volkow, N D AU - Hitzemann, R AU - Wang, G J AU - Fowler, J S AU - Burr, G AU - Pascani, K AU - Dewey, S L AU - Wolf, A P AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1992/08// PY - 1992 DA - August 1992 SP - 1016 EP - 1022 VL - 149 IS - 8 SN - 0002-953X, 0002-953X KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Deoxyglucose KW - 9G2MP84A8W KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Cerebral Cortex -- metabolism KW - Humans KW - Adult KW - Deoxyglucose -- analogs & derivatives KW - Brain Diseases -- diagnosis KW - Tomography, Emission-Computed KW - Middle Aged KW - Brain Diseases -- etiology KW - Male KW - Brain Diseases -- metabolism KW - Deoxyglucose -- metabolism KW - Alcoholism -- diagnosis KW - Glucose -- metabolism KW - Alcoholism -- metabolism KW - Brain -- metabolism KW - Brain -- diagnostic imaging KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73092948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Decreased+brain+metabolism+in+neurologically+intact+healthy+alcoholics.&rft.au=Volkow%2C+N+D%3BHitzemann%2C+R%3BWang%2C+G+J%3BFowler%2C+J+S%3BBurr%2C+G%3BPascani%2C+K%3BDewey%2C+S+L%3BWolf%2C+A+P&rft.aulast=Volkow&rft.aufirst=N&rft.date=1992-08-01&rft.volume=149&rft.issue=8&rft.spage=1016&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-26 N1 - Date created - 1992-08-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Brain imaging of an alcoholic with MRI, SPECT, and PET. AN - 75543000; 1343215 AB - A medically healthy chronic alcoholic without evidence of neurological and neuropsychological impairment was studied with magnetic resonance imaging (MRI), single photon emission computerized tomography (SPECT), and positron emission tomography (PET). An age-matched normal volunteer was evaluated with the same scans for comparison. The MRI of the alcoholic revealed prominent ventricles and mild cortical atrophy. SPECT and PET revealed predominant involvement of the frontal cortex as shown by decreased frontal blood flow and metabolism. This case illustrates the sensitivity of brain imaging techniques in detecting cerebral abnormalities even in the absence of neurologic and/or neuropsychological impairments. JF - American journal of physiologic imaging AU - Wang, G J AU - Volkow, N D AU - Hitzemann, R AU - Oster, Z H AU - Roque, C AU - Cestaro, V AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. PY - 1992 SP - 194 EP - 198 VL - 7 IS - 3-4 SN - 0885-8276, 0885-8276 KW - Fluorine Radioisotopes KW - 0 KW - Organotechnetium Compounds KW - Oximes KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Technetium Tc 99m Exametazime KW - 3B744AG22N KW - Deoxyglucose KW - 9G2MP84A8W KW - Index Medicus KW - Sensitivity and Specificity KW - Humans KW - Deoxyglucose -- analogs & derivatives KW - Middle Aged KW - Male KW - Magnetic Resonance Imaging KW - Tomography, Emission-Computed, Single-Photon KW - Alcoholism -- diagnostic imaging KW - Alcoholism -- diagnosis KW - Brain -- pathology KW - Tomography, Emission-Computed KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75543000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiologic+imaging&rft.atitle=Brain+imaging+of+an+alcoholic+with+MRI%2C+SPECT%2C+and+PET.&rft.au=Wang%2C+G+J%3BVolkow%2C+N+D%3BHitzemann%2C+R%3BOster%2C+Z+H%3BRoque%2C+C%3BCestaro%2C+V&rft.aulast=Wang&rft.aufirst=G&rft.date=1992-07-01&rft.volume=7&rft.issue=3-4&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiologic+imaging&rft.issn=08858276&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-10 N1 - Date created - 1994-03-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Long-term frontal brain metabolic changes in cocaine abusers. AN - 73094333; 1636149 AB - Neurological complications from cocaine use are well recognized. We propose that chronic cocaine use can also cause clinically silent brain dysfunction. We investigated brain glucose metabolism with positron emission tomography (PET) and 2-deoxy-2[18F] fluoro-D-glucose (FDG) in 21 neurologically intact chronic cocaine abusers (C) and 18 normal controls (N). The cocaine abusers were tested 1-6 weeks after the last use of cocaine and seven were retested after a 3 month drug-free period. Global cerebral glucose metabolism was not significantly different between controls and cocaine abusers (N = 38.4 +/- 3, C = 36.5 +/- 5 mumol/100 g of tissue, min). However, cocaine abusers had significantly (P less than 0.05) lower metabolic activity in 16 of the 21 left frontal regions and 8 of the 21 right frontal regions. These decreases persisted after 3-4 months of detoxification and were correlated with the dose (P less than or equal to 0.01) and the years of cocaine use (P less than or equal to 0.05). This study shows reduced rates of frontal metabolism in neurologically intact cocaine abusers that persist even after 3-4 months of detoxification. JF - Synapse (New York, N.Y.) AU - Volkow, N D AU - Hitzemann, R AU - Wang, G J AU - Fowler, J S AU - Wolf, A P AU - Dewey, S L AU - Handlesman, L AD - Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 184 EP - 190 VL - 11 IS - 3 SN - 0887-4476, 0887-4476 KW - Crack Cocaine KW - 0 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Depression -- etiology KW - Humans KW - Glucose -- metabolism KW - Depression -- psychology KW - Adult KW - Tomography, Emission-Computed KW - Brain -- diagnostic imaging KW - Male KW - Female KW - Brain Chemistry -- drug effects KW - Frontal Lobe -- metabolism KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73094333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Long-term+frontal+brain+metabolic+changes+in+cocaine+abusers.&rft.au=Volkow%2C+N+D%3BHitzemann%2C+R%3BWang%2C+G+J%3BFowler%2C+J+S%3BWolf%2C+A+P%3BDewey%2C+S+L%3BHandlesman%2C+L&rft.aulast=Volkow&rft.aufirst=N&rft.date=1992-07-01&rft.volume=11&rft.issue=3&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-24 N1 - Date created - 1992-08-24 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Erratum In: Synapse 1992 Sep;12(1):86 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Lung inflammation in coal miners assessed by uptake of 67Ga-citrate and clearance of inhaled 99mTc-labeled diethylenetriamine pentaacetate aerosol. AN - 73060674; 1626813 AB - We compared the diffuse lung uptake of 67Ga-citrate, an index of inflammatory lung activity, with the lung clearance of inhaled 99mTc-labeled diethylenetriamine pentaacetate (DTPA) aerosol, an index of pulmonary epithelial permeability, in a group of 19 West Virginia coal miners whose pulmonary status was compatible with coal worker's pneumoconiosis. 99mTc-DTPA clearance alone and 67Ga-citrate uptake alone were measured in nine and five additional subjects, respectively. The objective of this study was to determine if increased 99mTc-DTPA lung clearance was caused by inflammation at the lung epithelial surfaces. Subjects inhaled approximately 150 microCi (approximately 5.6 MBq) of 99mTc-DTPA aerosol, and quantitative gamma camera images of the lungs were acquired at 1-min increments for 25 min. Regions of interest (ROI) were selected to include (1) both lungs; (2) each individual lung; and (3) the upper, middle, and lower thirds of each lung. 99mTc-DTPA clearance was determined from the slopes of the respective time-activity plots for the different ROI. Each subject was intravenously administered 50 miCroCk (1.9 MBq)/kg 67Ga-citrate 48 to 72 h before imaging the body between neck and pelvis. The extent of 67Ga-citrate lung uptake was expressed as the gallium index (GI). Mean radioaerosol clearance half-time (T1/2) for the six nonsmoking coal miners (60.6 +/- 16.0 min) was significantly shorter (p less than 0.001) than for the nonsmoking control group (123.8 +/- 28.7 min). T1/2 for the 12 smoking miners (18.4 +/- 10.2 min) was shorter than for the smoking control group (33.1 +/- 17.8 min), but the difference did not attain statistical significance.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The American review of respiratory disease AU - Susskind, H AU - Rom, W N AD - Clinical Research Center, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 47 EP - 52 VL - 146 IS - 1 SN - 0003-0805, 0003-0805 KW - Citrates KW - 0 KW - Gallium Radioisotopes KW - Citric Acid KW - 2968PHW8QP KW - Technetium Tc 99m Pentetate KW - VW78417PU1 KW - Abridged Index Medicus KW - Index Medicus KW - Pulmonary Gas Exchange KW - Smoking KW - Respiratory Mechanics KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Radionuclide Imaging KW - Inflammation KW - Pneumoconiosis -- diagnostic imaging KW - Lung -- diagnostic imaging KW - Coal Mining KW - Pneumoconiosis -- physiopathology KW - Pneumoconiosis -- pathology KW - Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73060674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+review+of+respiratory+disease&rft.atitle=Lung+inflammation+in+coal+miners+assessed+by+uptake+of+67Ga-citrate+and+clearance+of+inhaled+99mTc-labeled+diethylenetriamine+pentaacetate+aerosol.&rft.au=Susskind%2C+H%3BRom%2C+W+N&rft.aulast=Susskind&rft.aufirst=H&rft.date=1992-07-01&rft.volume=146&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=The+American+review+of+respiratory+disease&rft.issn=00030805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-08-07 N1 - Date created - 1992-08-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Mineralogy of IDPs with known (super 4) He and trace element contents AN - 50277069; 1994-008942 JF - Meteoritics AU - Kloeck, W AU - Flynn, G J AU - Sutton, S R AU - Nier, A O AU - Anonymous Y1 - 1992/07// PY - 1992 DA - July 1992 SP - 243 EP - 244 PB - Arizona State University, Center for Meteorite Studies, Tempe, AZ VL - 27 IS - 3 SN - 0026-1114, 0026-1114 KW - isotopes KW - cosmogenic elements KW - cosmochemistry KW - He-4 KW - interplanetary dust KW - stable isotopes KW - mineral composition KW - noble gases KW - helium KW - particulate materials KW - trace elements KW - geochemistry KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50277069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Meteoritics&rft.atitle=Mineralogy+of+IDPs+with+known+%28super+4%29+He+and+trace+element+contents&rft.au=Kloeck%2C+W%3BFlynn%2C+G+J%3BSutton%2C+S+R%3BNier%2C+A+O%3BAnonymous&rft.aulast=Kloeck&rft.aufirst=W&rft.date=1992-07-01&rft.volume=27&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Meteoritics&rft.issn=00261114&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 55th annual meeting, Meteoritical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1994-01-01 N1 - PubXState - AZ N1 - Document feature - 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - MERTAW N1 - SubjectsTermNotLitGenreText - cosmochemistry; cosmogenic elements; geochemistry; He-4; helium; interplanetary dust; isotopes; mineral composition; noble gases; particulate materials; stable isotopes; trace elements ER - TY - JOUR T1 - Mutation and killing of Escherichia coli expressing a cloned Bacillus subtilis gene whose product alters DNA conformation. AN - 72902558; 1314805 AB - Expression of the Bacillus subtilis gene coding for SspC, a small, acid-soluble protein, caused both killing and mutation in a number of Escherichia coli B and K-12 strains. SspC was previously shown to bind E. coli DNA in vivo, and in vitro this protein binds DNA and converts it into an A-like conformation. Analysis of revertants of nonsense mutations showed that SspC caused single-base changes, and a greater proportion of these were at A-T base pairs. Mutation in the recA gene abolished the induction of mutations upon synthesis of SspC, but the killing was only slightly greater than in RecA+ cells. Mutations in the umuC and umuD genes eliminated most of the mutagenic effect of SspC but not the killing, while the lexA mutation increased mutagenesis but did not appreciably affect the killing. Since there was neither killing nor mutation of E. coli after synthesis of a mutant SspC which does not bind DNA, it appears likely that the binding of wild-type SspC to DNA, with the attendant conformational change, was responsible for the killing and mutation. A strain containing the B. subtilis gene that is constitutive for the RecA protein at 42 degrees C showed a lower frequency of mutation when that temperature was used to induce the RecA protein than when the temperature was 30 degrees C, where the RecA level is low, suggesting that at the elevated temperature the high RecA level could be inhibiting binding of the B. subtilis protein to DNA. JF - Journal of bacteriology AU - Setlow, J K AU - Randesi, M AU - Adams, J G AU - Setlow, B AU - Setlow, P AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1992/05// PY - 1992 DA - May 1992 SP - 2943 EP - 2950 VL - 174 IS - 9 SN - 0021-9193, 0021-9193 KW - Bacterial Proteins KW - 0 KW - Escherichia coli Proteins KW - LexA protein, Bacteria KW - Sigma Factor KW - Transcription Factors KW - spoIIR protein, Bacillus subtilis KW - spore-specific proteins, Bacillus KW - Isopropyl Thiogalactoside KW - 367-93-1 KW - Rec A Recombinases KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - UmuD protein, E coli KW - Serine Endopeptidases KW - EC 3.4.21.- KW - Index Medicus KW - Rec A Recombinases -- genetics KW - Isopropyl Thiogalactoside -- pharmacology KW - Nucleic Acid Conformation -- drug effects KW - Cloning, Molecular KW - Mutagenesis -- drug effects KW - Bacillus subtilis -- genetics KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- biosynthesis KW - Bacterial Proteins -- pharmacology KW - Escherichia coli -- drug effects KW - Escherichia coli -- physiology KW - Escherichia coli -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72902558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Mutation+and+killing+of+Escherichia+coli+expressing+a+cloned+Bacillus+subtilis+gene+whose+product+alters+DNA+conformation.&rft.au=Setlow%2C+J+K%3BRandesi%2C+M%3BAdams%2C+J+G%3BSetlow%2C+B%3BSetlow%2C+P&rft.aulast=Setlow&rft.aufirst=J&rft.date=1992-05-01&rft.volume=174&rft.issue=9&rft.spage=2943&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-05-22 N1 - Date created - 1992-05-22 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: J Mol Biol. 1969 May 14;41(3):459-72 [4896022] J Biol Chem. 1956 Jan;218(1):97-106 [13278318] J Mol Biol. 1967 Jun 28;26(3):437-47 [6029739] J Mol Biol. 1983 Feb 25;164(2):175-92 [6302271] Microbiol Rev. 1984 Mar;48(1):60-93 [6371470] Proc Natl Acad Sci U S A. 1984 Dec;81(23):7539-43 [6390441] Mol Gen Genet. 1980;180(2):283-91 [6450870] Genetics. 1964 Feb;49:237-46 [14124942] Gene. 1977;2(2):95-113 [344137] Mol Gen Genet. 1978 Sep 20;165(1):87-93 [362169] Microbiol Rev. 1988 Sep;52(3):354-74 [3054467] Bacteriol Rev. 1976 Dec;40(4):869-907 [795416] Basic Life Sci. 1975;5A:355-67 [1103845] Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):77-81 [1898779] J Bacteriol. 1991 Mar;173(5):1642-53 [1900278] Carcinogenesis. 1991 Jul;12(7):1161-7 [2070480] Methods Enzymol. 1990;185:60-89 [2199796] Mol Gen Genet. 1977 Nov 14;156(2):121-31 [340898] Mutat Res. 1975 Jun;28(3):347-54 [1094281] Mol Gen Genet. 1975 Oct 22;140(4):309-332 [1107802] J Bacteriol. 1991 Aug;173(15):4827-35 [1906873] J Bacteriol. 1990 Dec;172(12):6900-6 [2123857] Annu Rev Microbiol. 1988;42:319-38 [3059997] Annu Rev Microbiol. 1969;23:487-514 [4899079] Genetics. 1966 Jun;53(6):1137-50 [5335129] Proc Natl Acad Sci U S A. 1983 Jan;80(1):65-9 [6337375] Cell. 1984 Jun;37(2):675-82 [6373019] Science. 1966 Jun 3;152(3727):1345-53 [5327888] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Distribution and kinetics of carbon-11-cocaine in the human body measured with PET. AN - 72862272; 1552335 AB - The extent to which the toxic properties of cocaine are related to its accumulation in various organs is not known. This study investigates cocaine uptake in the human body using 11C-cocaine and PET in 14 healthy males. The rate of uptake and clearance of 11C-cocaine varied among organs: peak uptake occurred in the lungs at 45 sec, in the heart and kidneys at 2-3 min, in the adrenals at 7-9 min, and in the liver at 10-15 min. Half-peak clearances were 90 sec in the lungs, 10 min in the heart and kidneys and 22 min in the adrenals. Liver radioactivity plateaued 10-15 min after injection and remained constant thereafter (40 min). Lung radioactivity paralleled that of plasma. The average uptake at peak was 0.007% (s.d., 0.001) dose/cc in the heart, 0.014% (s.d., 0.002) dose/cc in the kidney, 0.014% (s.d., 0.002) dose/cc in the liver and 0.034% (s.d., 0.001) dose/cc in the adrenals. The significant accumulation of cocaine in human heart, kidneys, adrenals and liver could contribute to its toxicity. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Volkow, N D AU - Fowler, J S AU - Wolf, A P AU - Wang, G J AU - Logan, J AU - MacGregor, R AU - Dewey, S L AU - Schlyer, D AU - Hitzemann, R AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 521 EP - 525 VL - 33 IS - 4 SN - 0161-5505, 0161-5505 KW - Carbon Radioisotopes KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Reference Values KW - Humans KW - Adult KW - Tomography, Emission-Computed KW - Middle Aged KW - Tissue Distribution KW - Male KW - Cocaine -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72862272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Distribution+and+kinetics+of+carbon-11-cocaine+in+the+human+body+measured+with+PET.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWolf%2C+A+P%3BWang%2C+G+J%3BLogan%2C+J%3BMacGregor%2C+R%3BDewey%2C+S+L%3BSchlyer%2C+D%3BHitzemann%2C+R&rft.aulast=Volkow&rft.aufirst=N&rft.date=1992-04-01&rft.volume=33&rft.issue=4&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-28 N1 - Date created - 1992-04-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Synchrotron computed microtomography analysis of drill core specimens; I, Experimental AN - 50374848; 1993-009664 JF - Eos, Transactions, American Geophysical Union AU - Spanne, P AU - Jones, K W AU - Rivers, M L AU - Sutton, S R AU - Brown, S R AU - Lindquist, W B AU - Lee, S M AU - Anonymous Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 308 PB - American Geophysical Union, Washington, DC VL - 73 IS - 14, supplement SN - 0096-3941, 0096-3941 KW - tomography KW - synchrotron methods KW - experimental studies KW - microtomography KW - cores KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50374848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Synchrotron+computed+microtomography+analysis+of+drill+core+specimens%3B+I%2C+Experimental&rft.au=Spanne%2C+P%3BJones%2C+K+W%3BRivers%2C+M+L%3BSutton%2C+S+R%3BBrown%2C+S+R%3BLindquist%2C+W+B%3BLee%2C+S+M%3BAnonymous&rft.aulast=Spanne&rft.aufirst=P&rft.date=1992-04-01&rft.volume=73&rft.issue=14%2C+supplement&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1992 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - cores; experimental studies; microtomography; synchrotron methods; tomography ER - TY - JOUR T1 - Synchrotron computed microtomography analysis of drill core specimens; II, Interpretation AN - 50373489; 1993-009617 JF - Eos, Transactions, American Geophysical Union AU - Lindquist, W B AU - Lee, S M AU - Spanne, P AU - Jones, K W AU - Anonymous Y1 - 1992/04// PY - 1992 DA - April 1992 SP - 308 PB - American Geophysical Union, Washington, DC VL - 73 IS - 14, supplement SN - 0096-3941, 0096-3941 KW - tomography KW - synchrotron methods KW - microtomography KW - cores KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50373489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Synchrotron+computed+microtomography+analysis+of+drill+core+specimens%3B+II%2C+Interpretation&rft.au=Lindquist%2C+W+B%3BLee%2C+S+M%3BSpanne%2C+P%3BJones%2C+K+W%3BAnonymous&rft.aulast=Lindquist&rft.aufirst=W&rft.date=1992-04-01&rft.volume=73&rft.issue=14%2C+supplement&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1992 spring meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - cores; microtomography; synchrotron methods; tomography ER - TY - JOUR T1 - Computed microtomography (CMT) of extraterrestrial objects using a linear photodiode array detector AN - 52292300; 2000-078531 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Sutton, S R AU - Spanne, P AU - Rivers, M L AU - Jones, K W AU - Anonymous Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 1393 EP - 1394 PB - Lunar and Planetary Science Conference, Houston, TX VL - 23 KW - tomography KW - meteorites KW - linear photodiode array detector KW - imagery KW - stony meteorites KW - computed tomography KW - three-dimensional models KW - chondrites KW - microtomography KW - instruments KW - observations KW - 05B:Petrology of meteorites and tektites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52292300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Computed+microtomography+%28CMT%29+of+extraterrestrial+objects+using+a+linear+photodiode+array+detector&rft.au=Sutton%2C+S+R%3BSpanne%2C+P%3BRivers%2C+M+L%3BJones%2C+K+W%3BAnonymous&rft.aulast=Sutton&rft.aufirst=S&rft.date=1992-03-01&rft.volume=23&rft.issue=&rft.spage=1393&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-third lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 6 N1 - PubXState - TX N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - chondrites; computed tomography; imagery; instruments; linear photodiode array detector; meteorites; microtomography; observations; stony meteorites; three-dimensional models; tomography ER - TY - JOUR T1 - Antarctic micrometeorites; trace element contents and textures of 50 to 100 mu m particles AN - 52292124; 2000-078530 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Sutton, S R AU - Prinz, M AU - Maurette, M AU - Nehru, C E AU - Weisberg, M K AU - Bajt, S AU - Anonymous Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 1391 EP - 1392 PB - Lunar and Planetary Science Conference, Houston, TX VL - 23 KW - micrometeorites KW - meteorites KW - mineral composition KW - Antarctica KW - stony meteorites KW - sampling KW - textures KW - trace elements KW - interpretation KW - chondrites KW - geochemistry KW - 05B:Petrology of meteorites and tektites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52292124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Antarctic+micrometeorites%3B+trace+element+contents+and+textures+of+50+to+100+mu+m+particles&rft.au=Sutton%2C+S+R%3BPrinz%2C+M%3BMaurette%2C+M%3BNehru%2C+C+E%3BWeisberg%2C+M+K%3BBajt%2C+S%3BAnonymous&rft.aulast=Sutton&rft.aufirst=S&rft.date=1992-03-01&rft.volume=23&rft.issue=&rft.spage=1391&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-third lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 6 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - Antarctica; chondrites; geochemistry; interpretation; meteorites; micrometeorites; mineral composition; sampling; stony meteorites; textures; trace elements ER - TY - JOUR T1 - The influence of microbial activity and sedimentary organic carbon on the isotope geochemistry of the Middendorf Aquifer AN - 50182114; 1993-047946 AB - Microorganisms present in deep Atlantic coastal plain sediments affect the geochemical evolution of groundwater and its chemical and isotopic composition, yet the factors controlling their origin, distribution, and diversity are poorly understood. The evolution of the groundwater chemistry, the fractionation of stable carbon isotopes, and the groundwater age are all indicators of the inorganic and microbial reactions occurring along a given flow path from groundwater recharge to groundwater discharge. In this study, tritium, (super 14) C, and groundwater chemistry along three flow paths of the Middendorf aquifer in South Carolina were analyzed. The (super 14) C ranged from 89 percent modern carbon (pmC) in the recharge zone to 9.9 pmC in the distal borehole; the delta (super 13) C remained relatively constant at approximately -22 per mil, suggesting microbial oxidation of organic carbon. Carbon isotope analyses of particulate organic carbon from core sediments and groundwater chemistry were used to model the carbon chemistry; the groundwater ages obtained from (super 14) C ranged from modern to 11,500 years B.P. The highest frequencies of occurrence, numbers, and diversity of aerobic and anaerobic bacteria were found in boreholes near the recharge zone where the calculated ages were <1000 years B.P. The transport of microorganisms from the recharge zone may be responsible for this distribution as well as the electron acceptors necessary to support this diverse community of bacteria. The presence of both aerobic heterotrophs and anaerobic sulfate- and iron-reducing bacteria in the core sediments suggested the occurrence of anaerobic microsites throughout this otherwise aerobic aquifer. The highest in situ microbial respiration rate, as determined by modeling, was found along a flow path near the recharge area. It is likely that the electron acceptors necessary for supporting a diverse microbial community are depleted by the time the groundwater residence time in the Middendorf aquifer exceeds several hundred years. Copyright 1992 by the American Geophysical Union. JF - Water Resources Research AU - Murphy, Ellyn M AU - Schramke, Janet A AU - Frederickson, James K AU - Bledsoe, Horace W AU - Francis, A J AU - Sklarew, Deborah S AU - Linehan, John C Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 723 EP - 740 PB - American Geophysical Union, Washington, DC VL - 28 IS - 3 SN - 0043-1397, 0043-1397 KW - United States KW - South Carolina KW - isotopes KW - southwestern South Carolina KW - Aiken County South Carolina KW - tritium KW - Holocene KW - stable isotopes KW - ground water KW - upper Pleistocene KW - Cenozoic KW - radioactive isotopes KW - carbon KW - movement KW - age KW - organic carbon KW - Middendorf Aquifer KW - Eh KW - Barnwell County South Carolina KW - Atlantic Coastal Plain KW - organic materials KW - Quaternary KW - isotope ratios KW - C-13/C-12 KW - biota KW - aquifers KW - models KW - CSOTOP KW - organic compounds KW - hydrogen KW - Pleistocene KW - C-14 KW - Savannah River Site KW - microorganisms KW - 21:Hydrogeology KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50182114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Resources+Research&rft.atitle=The+influence+of+microbial+activity+and+sedimentary+organic+carbon+on+the+isotope+geochemistry+of+the+Middendorf+Aquifer&rft.au=Murphy%2C+Ellyn+M%3BSchramke%2C+Janet+A%3BFrederickson%2C+James+K%3BBledsoe%2C+Horace+W%3BFrancis%2C+A+J%3BSklarew%2C+Deborah+S%3BLinehan%2C+John+C&rft.aulast=Murphy&rft.aufirst=Ellyn&rft.date=1992-03-01&rft.volume=28&rft.issue=3&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Water+Resources+Research&rft.issn=00431397&rft_id=info:doi/10.1029%2F91WR02678 L2 - http://www.agu.org/journals/wr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 75 N1 - PubXState - DC N1 - Document feature - illus. incl. 7 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - WRERAQ N1 - SubjectsTermNotLitGenreText - age; Aiken County South Carolina; aquifers; Atlantic Coastal Plain; Barnwell County South Carolina; biota; C-13/C-12; C-14; carbon; Cenozoic; CSOTOP; Eh; ground water; Holocene; hydrogen; isotope ratios; isotopes; microorganisms; Middendorf Aquifer; models; movement; organic carbon; organic compounds; organic materials; Pleistocene; Quaternary; radioactive isotopes; Savannah River Site; South Carolina; southwestern South Carolina; stable isotopes; tritium; United States; upper Pleistocene DO - http://dx.doi.org/10.1029/91WR02678 ER - TY - JOUR T1 - Bulk composition and mineralogy of Antarctic micrometeorites AN - 50137748; 1995-033534 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Kloeck, W AU - Beckerling, W AU - Spettel, B AU - Flynn, G AU - Sutton, S AU - Anonymous Y1 - 1992/03// PY - 1992 DA - March 1992 SP - 697 EP - 698 PB - Lunar and Planetary Science Conference, Houston, TX VL - 23 KW - stony meteorites KW - cobalt KW - selenium KW - Arctic region KW - platinum group KW - TEM data KW - iridium KW - micrometeorites KW - meteorites KW - Greenland KW - cosmic dust KW - mineral composition KW - Antarctica KW - metals KW - nickel KW - interpretation KW - chondrites KW - geochemistry KW - 05B:Petrology of meteorites and tektites KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50137748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Bulk+composition+and+mineralogy+of+Antarctic+micrometeorites&rft.au=Kloeck%2C+W%3BBeckerling%2C+W%3BSpettel%2C+B%3BFlynn%2C+G%3BSutton%2C+S%3BAnonymous&rft.aulast=Kloeck&rft.aufirst=W&rft.date=1992-03-01&rft.volume=23&rft.issue=&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-third lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - Number of references - 4 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - Antarctica; Arctic region; chondrites; cobalt; cosmic dust; geochemistry; Greenland; interpretation; iridium; metals; meteorites; micrometeorites; mineral composition; nickel; platinum group; selenium; stony meteorites; TEM data ER - TY - JOUR T1 - Biodistribution and toxicity of 2,4-divinyl-nido-o-carboranyldeuteroporphyrin IX in mice. AN - 72821052; 1540204 AB - BALB/c mice with transplanted subcutaneous KHJJ mammary carcinomas were given 2,4-divinyl-nido-o-carboranyldeuteroporphyrin IX (VCDP), a prospective boron carrier for boron neutron-capture therapy, to determine the dose schedule that results in maximal boron uptake in tumor. A total dose of 270 +/- 10 micrograms/g body weight given in a 4-day multiple intraperitoneal injection schedule (3/day) resulted in 30-50 micrograms boron/g tumor. After such a dose, thrombocytopenia, granulocytosis and altered liver enzyme levels were measured in the blood. Blood boron clearance was followed for an 18 hr to 6 day post-injection period. Toxic effects of VCDP subsided within 4-6 days after the last injection. In view of the greater than 30 micrograms/g peak accumulation of boron in tumor from VCDP and the subsequent rapid reversal of VCDP toxicity, further studies of VCDP in small mammals relevant to its distribution, toxicity and potential clinical use for neutron-capture therapy of tumors appear warranted. JF - Biochemical pharmacology AU - Miura, M AU - Micca, P L AU - Heinrichs, J C AU - Gabel, D AU - Fairchild, R G AU - Slatkin, D N AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1992/02/04/ PY - 1992 DA - 1992 Feb 04 SP - 467 EP - 476 VL - 43 IS - 3 SN - 0006-2952, 0006-2952 KW - Boron Compounds KW - 0 KW - Porphyrins KW - tetraphenylporphine sulfonate KW - 35218-75-8 KW - Index Medicus KW - Animals KW - Mammary Neoplasms, Experimental -- radiotherapy KW - Metabolic Clearance Rate KW - Mice KW - Tissue Distribution KW - Mice, Inbred BALB C KW - Mammary Neoplasms, Experimental -- metabolism KW - Mammary Neoplasms, Experimental -- blood KW - Female KW - Porphyrins -- toxicity KW - Boron Compounds -- toxicity KW - Boron Compounds -- pharmacokinetics KW - Porphyrins -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72821052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Biodistribution+and+toxicity+of+2%2C4-divinyl-nido-o-carboranyldeuteroporphyrin+IX+in+mice.&rft.au=Miura%2C+M%3BMicca%2C+P+L%3BHeinrichs%2C+J+C%3BGabel%2C+D%3BFairchild%2C+R+G%3BSlatkin%2C+D+N&rft.aulast=Miura&rft.aufirst=M&rft.date=1992-02-04&rft.volume=43&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-04-02 N1 - Date created - 1992-04-02 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Erratum In: Biochem Pharmacol 1995 Sep 7;50(6):893-4 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Microdistribution of lead in bone: a new approach. AN - 73523832; 1302309 AB - A knowledge of the microdistribution of lead in bone is important in order to understand the mechanisms for accumulation and release of lead. The availability of the synchrotron x-ray microscope for sensitive measurements of bone content and distribution of lead provides a valuable tool which, when combined with kinetic, balance, and tissue measurements, can lead to better evaluation of lead toxicity. It may also provide the basis for the development of a suitable model of how lead behaves in the human body. An outline of an experimental protocol for exploitation of the x-ray microscope is given, along with synchrotron x-ray microscope measurements of the distribution of gallium in rat bone that demonstrate the feasibility of the experimental approach. JF - Neurotoxicology AU - Jones, K W AU - Bockman, R S AU - Bronner, F AD - Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1992 PY - 1992 DA - 1992 SP - 835 EP - 841 VL - 13 IS - 4 SN - 0161-813X, 0161-813X KW - Lead KW - 2P299V784P KW - Gallium KW - CH46OC8YV4 KW - Index Medicus KW - Animals KW - Gallium -- analysis KW - Humans KW - Electron Probe Microanalysis KW - Bone and Bones -- chemistry KW - Synchrotrons KW - Lead -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73523832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Microdistribution+of+lead+in+bone%3A+a+new+approach.&rft.au=Jones%2C+K+W%3BBockman%2C+R+S%3BBronner%2C+F&rft.aulast=Jones&rft.aufirst=K&rft.date=1992-01-01&rft.volume=13&rft.issue=4&rft.spage=835&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1993-06-07 N1 - Date created - 1993-06-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Geological and climatic time scales of nutrient variability AN - 52822668; 1996-062703 JF - Environmental Science Research AU - Barber, Richard T A2 - Falkowski, Paul G. A2 - Woodhead, Avril D. A2 - Vivirito, Katherine Y1 - 1992 PY - 1992 DA - 1992 SP - 89 EP - 106 PB - Plenum, New York, NY VL - 43 SN - 0090-0427, 0090-0427 KW - upwelling KW - patterns KW - oxygen KW - sediment transport KW - phosphorus KW - temperature KW - Southern Oscillation KW - nitrogen KW - time scales KW - nutrients KW - provenance KW - marine environment KW - El Nino KW - carbon KW - seasonal variations KW - climate KW - productivity KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52822668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+Research&rft.atitle=Geological+and+climatic+time+scales+of+nutrient+variability&rft.au=Barber%2C+Richard+T&rft.aulast=Barber&rft.aufirst=Richard&rft.date=1992-01-01&rft.volume=43&rft.issue=&rft.spage=89&rft.isbn=0306441926&rft.btitle=&rft.title=Environmental+Science+Research&rft.issn=00900427&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 37th Brookhaven symposium in Biology N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 56 N1 - PubXState - NY N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon; climate; El Nino; marine environment; nitrogen; nutrients; oxygen; patterns; phosphorus; productivity; provenance; seasonal variations; sediment transport; Southern Oscillation; temperature; time scales; upwelling ER - TY - JOUR T1 - Satellite ocean color observations of global biogeochemical cycles AN - 52821952; 1996-062704 JF - Environmental Science Research AU - Lewis, Marlon R A2 - Falkowski, Paul G. A2 - Woodhead, Avril D. A2 - Vivirito, Katherine Y1 - 1992 PY - 1992 DA - 1992 SP - 139 EP - 153 PB - Plenum, New York, NY VL - 43 SN - 0090-0427, 0090-0427 KW - organic materials KW - cycles KW - photosynthesis KW - phytoplankton KW - pigments KW - biochemistry KW - photochemistry KW - prediction KW - plankton KW - satellite methods KW - temperature KW - geochemical cycle KW - carbon dioxide KW - organic compounds KW - optical properties KW - color KW - marine environment KW - seasonal variations KW - geochemistry KW - remote sensing KW - productivity KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52821952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+Research&rft.atitle=Satellite+ocean+color+observations+of+global+biogeochemical+cycles&rft.au=Lewis%2C+Marlon+R&rft.aulast=Lewis&rft.aufirst=Marlon&rft.date=1992-01-01&rft.volume=43&rft.issue=&rft.spage=139&rft.isbn=0306441926&rft.btitle=&rft.title=Environmental+Science+Research&rft.issn=00900427&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 37th Brookhaven symposium in Biology N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 66 N1 - PubXState - NY N1 - Document feature - 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - biochemistry; carbon dioxide; color; cycles; geochemical cycle; geochemistry; marine environment; optical properties; organic compounds; organic materials; photochemistry; photosynthesis; phytoplankton; pigments; plankton; prediction; productivity; remote sensing; satellite methods; seasonal variations; temperature ER - TY - JOUR T1 - Reading the sedimentary record of the ocean's productivity AN - 52819021; 1996-062707 JF - Environmental Science Research AU - Berger, W H AU - Herguera, J C A2 - Falkowski, Paul G. A2 - Woodhead, Avril D. A2 - Vivirito, Katherine Y1 - 1992 PY - 1992 DA - 1992 SP - 455 EP - 486 PB - Plenum, New York, NY VL - 43 SN - 0090-0427, 0090-0427 KW - organic materials KW - concentration KW - benthic taxa KW - Protista KW - assemblages KW - sedimentation KW - planktonic taxa KW - marine sedimentation KW - Foraminifera KW - organic compounds KW - sedimentation rates KW - marine environment KW - carbon KW - mathematical methods KW - sediments KW - Invertebrata KW - organic carbon KW - world ocean KW - microfossils KW - productivity KW - changes KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52819021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+Research&rft.atitle=Reading+the+sedimentary+record+of+the+ocean%27s+productivity&rft.au=Berger%2C+W+H%3BHerguera%2C+J+C&rft.aulast=Berger&rft.aufirst=W&rft.date=1992-01-01&rft.volume=43&rft.issue=&rft.spage=455&rft.isbn=0306441926&rft.btitle=&rft.title=Environmental+Science+Research&rft.issn=00900427&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 37th Brookhaven symposium in Biology N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 125 N1 - PubXState - NY N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - assemblages; benthic taxa; carbon; changes; concentration; Foraminifera; Invertebrata; marine environment; marine sedimentation; mathematical methods; microfossils; organic carbon; organic compounds; organic materials; planktonic taxa; productivity; Protista; sedimentation; sedimentation rates; sediments; world ocean ER - TY - JOUR T1 - Do marine phytoplankton influence global climate? AN - 52818999; 1996-062708 JF - Environmental Science Research AU - Holligan, P M A2 - Falkowski, Paul G. A2 - Woodhead, Avril D. A2 - Vivirito, Katherine Y1 - 1992 PY - 1992 DA - 1992 SP - 487 EP - 501 PB - Plenum, New York, NY VL - 43 SN - 0090-0427, 0090-0427 KW - imagery KW - phytoplankton KW - biochemistry KW - oxidation KW - global KW - plankton KW - dimethyl sulfide KW - distribution KW - temperature KW - carbon dioxide KW - nutrients KW - models KW - optical properties KW - marine environment KW - sulfur KW - greenhouse effect KW - world ocean KW - climate KW - productivity KW - changes KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52818999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+Research&rft.atitle=Do+marine+phytoplankton+influence+global+climate%3F&rft.au=Holligan%2C+P+M&rft.aulast=Holligan&rft.aufirst=P&rft.date=1992-01-01&rft.volume=43&rft.issue=&rft.spage=487&rft.isbn=0306441926&rft.btitle=&rft.title=Environmental+Science+Research&rft.issn=00900427&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 37th Brookhaven symposium in Biology N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 58 N1 - PubXState - NY N1 - Document feature - illus. incl. 1 plate N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - biochemistry; carbon dioxide; changes; climate; dimethyl sulfide; distribution; global; greenhouse effect; imagery; marine environment; models; nutrients; optical properties; oxidation; phytoplankton; plankton; productivity; sulfur; temperature; world ocean ER - TY - JOUR T1 - New production and the global carbon cycle AN - 52818987; 1996-062706 JF - Environmental Science Research AU - Sarmiento, Jorge L AU - Siegenthaler, Ulrich A2 - Falkowski, Paul G. A2 - Woodhead, Avril D. A2 - Vivirito, Katherine Y1 - 1992 PY - 1992 DA - 1992 SP - 317 EP - 332 PB - Plenum, New York, NY VL - 43 SN - 0090-0427, 0090-0427 KW - cycles KW - photosynthesis KW - human activity KW - biochemistry KW - global KW - photochemistry KW - distribution KW - variations KW - temperature KW - geochemical cycle KW - carbon dioxide KW - nutrients KW - models KW - time factor KW - carbon KW - greenhouse effect KW - chemical composition KW - geochemistry KW - world ocean KW - productivity KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52818987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+Research&rft.atitle=New+production+and+the+global+carbon+cycle&rft.au=Sarmiento%2C+Jorge+L%3BSiegenthaler%2C+Ulrich&rft.aulast=Sarmiento&rft.aufirst=Jorge&rft.date=1992-01-01&rft.volume=43&rft.issue=&rft.spage=317&rft.isbn=0306441926&rft.btitle=&rft.title=Environmental+Science+Research&rft.issn=00900427&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 37th Brookhaven symposium in Biology N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 49 N1 - PubXState - NY N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - biochemistry; carbon; carbon dioxide; chemical composition; cycles; distribution; geochemical cycle; geochemistry; global; greenhouse effect; human activity; models; nutrients; photochemistry; photosynthesis; productivity; temperature; time factor; variations; world ocean ER - TY - JOUR T1 - 37th Brookhaven symposium in Biology AN - 52818896; 1996-062702 JF - Environmental Science Research A2 - Falkowski, Paul G. A2 - Woodhead, Avril D. A2 - Vivirito, Katherine Y1 - 1992 PY - 1992 DA - 1992 SP - 550 PB - Plenum, New York, NY VL - 43 SN - 0090-0427, 0090-0427 KW - cycles KW - symposia KW - marine environment KW - biochemistry KW - geochemistry KW - productivity KW - geochemical cycle KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52818896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Environmental+Science+Research&rft.atitle=37th+Brookhaven+symposium+in+Biology&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1992-01-01&rft.volume=43&rft.issue=&rft.spage=&rft.isbn=0306441926&rft.btitle=&rft.title=Environmental+Science+Research&rft.issn=00900427&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 37th Brookhaven symposium in Biology N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - NY N1 - Document feature - illus. N1 - SuppNotes - Selected papers are cited separately N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - biochemistry; cycles; geochemical cycle; geochemistry; marine environment; productivity; symposia ER - TY - JOUR T1 - Photodegradation and geochemical fate of river carbon in the sea AN - 50387433; 1992-067891 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Mopper, Ken AU - Kieber, Robert J AU - Zhou, X AU - Anonymous Y1 - 1992 PY - 1992 DA - 1992 PB - American Chemical Society, Washington, DC VL - 203 SN - 0065-7727, 0065-7727 KW - organic materials KW - biodegradation KW - organic compounds KW - sea water KW - carbon KW - surface water KW - rivers and streams KW - photochemistry KW - solutes KW - geochemistry KW - geochemical cycle KW - 21:Hydrogeology KW - 07:Oceanography KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50387433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Photodegradation+and+geochemical+fate+of+river+carbon+in+the+sea&rft.au=Mopper%2C+Ken%3BKieber%2C+Robert+J%3BZhou%2C+X%3BAnonymous&rft.aulast=Mopper&rft.aufirst=Ken&rft.date=1992-01-01&rft.volume=203&rft.issue=&rft.spage=GEOC+62&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 203rd American Chemical Society national meeting N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 1992-01-01 N1 - PubXState - DC N1 - Last updated - 2014-03-14 N1 - SubjectsTermNotLitGenreText - biodegradation; carbon; geochemical cycle; geochemistry; organic compounds; organic materials; photochemistry; rivers and streams; sea water; solutes; surface water ER - TY - JOUR T1 - Productivity of zooxanthellae and biogeochemical cycles AN - 50330384; 1996-062705 JF - Environmental Science Research AU - Muscatine, Leonard AU - Weis, Virginia A2 - Falkowski, Paul G. A2 - Woodhead, Avril D. A2 - Vivirito, Katherine Y1 - 1992 PY - 1992 DA - 1992 SP - 257 EP - 271 PB - Plenum, New York, NY VL - 43 SN - 0090-0427, 0090-0427 KW - respiration KW - cycles KW - photosynthesis KW - zooxanthellae KW - fixation KW - biochemistry KW - Dinoflagellata KW - photochemistry KW - Coelenterata KW - geochemical cycle KW - nutrients KW - marine environment KW - carbon KW - palynomorphs KW - Anthozoa KW - Invertebrata KW - Cnidaria KW - bathymetry KW - ocean floors KW - microfossils KW - productivity KW - growth KW - 02B:Hydrochemistry KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50330384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+Research&rft.atitle=Productivity+of+zooxanthellae+and+biogeochemical+cycles&rft.au=Muscatine%2C+Leonard%3BWeis%2C+Virginia&rft.aulast=Muscatine&rft.aufirst=Leonard&rft.date=1992-01-01&rft.volume=43&rft.issue=&rft.spage=257&rft.isbn=0306441926&rft.btitle=&rft.title=Environmental+Science+Research&rft.issn=00900427&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 37th Brookhaven symposium in Biology N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 69 N1 - PubXState - NY N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Anthozoa; bathymetry; biochemistry; carbon; Cnidaria; Coelenterata; cycles; Dinoflagellata; fixation; geochemical cycle; growth; Invertebrata; marine environment; microfossils; nutrients; ocean floors; palynomorphs; photochemistry; photosynthesis; productivity; respiration; zooxanthellae ER - TY - JOUR T1 - Anaerobic microbial transformations of uranium and toxic metals in wastes AN - 50323165; 1993-028020 JF - Abstracts of Papers - American Chemical Society, National Meeting AU - Francis, A J AU - Dodge, C J AU - Gillow, J B AU - Anonymous Y1 - 1992 PY - 1992 DA - 1992 PB - American Chemical Society, Washington, DC VL - 203 SN - 0065-7727, 0065-7727 KW - thallophytes KW - biodegradation KW - toxic materials KW - Plantae KW - experimental studies KW - bioremediation KW - remediation KW - radioactive waste KW - decontamination KW - metals KW - bacteria KW - anaerobic environment KW - uranium KW - waste disposal KW - actinides KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50323165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.atitle=Anaerobic+microbial+transformations+of+uranium+and+toxic+metals+in+wastes&rft.au=Francis%2C+A+J%3BDodge%2C+C+J%3BGillow%2C+J+B%3BAnonymous&rft.aulast=Francis&rft.aufirst=A&rft.date=1992-01-01&rft.volume=203&rft.issue=&rft.spage=GEOC+172&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+-+American+Chemical+Society%2C+National+Meeting&rft.issn=00657727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 203rd American Chemical Society national meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - actinides; anaerobic environment; bacteria; biodegradation; bioremediation; decontamination; experimental studies; metals; Plantae; radioactive waste; remediation; thallophytes; toxic materials; uranium; waste disposal ER - TY - JOUR T1 - Wavelength dispersive detectors in synchrotron X-ray fluorescence microprobe analysis AN - 1648906357; 2015-007872 JF - Eos, Transactions, American Geophysical Union AU - Rivers, M L AU - Thorn, K S AU - Sutton, S R AU - Jones, K W AU - Anonymous Y1 - 1992 PY - 1992 DA - 1992 SP - 620 PB - American Geophysical Union, Washington, DC VL - 73 IS - 43, Suppl. SN - 0096-3941, 0096-3941 KW - zircon group KW - silicates KW - dispersivity KW - chemical analysis KW - X-ray fluorescence KW - zircon KW - trace-element analyses KW - synchrotron radiation KW - nesosilicates KW - galena KW - electron probe KW - metals KW - orthosilicates KW - X-ray analysis KW - rare earths KW - sulfides KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1648906357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Wavelength+dispersive+detectors+in+synchrotron+X-ray+fluorescence+microprobe+analysis&rft.au=Rivers%2C+M+L%3BThorn%2C+K+S%3BSutton%2C+S+R%3BJones%2C+K+W%3BAnonymous&rft.aulast=Rivers&rft.aufirst=M&rft.date=1992-01-01&rft.volume=73&rft.issue=43%2C+Suppl.&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ L2 - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%292324-9250 LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1992 fall meeting N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. N1 - Date revised - 2015-01-01 N1 - PubXState - DC N1 - Last updated - 2015-01-29 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - chemical analysis; dispersivity; electron probe; galena; metals; nesosilicates; orthosilicates; rare earths; silicates; sulfides; synchrotron radiation; trace-element analyses; X-ray analysis; X-ray fluorescence; zircon; zircon group ER - TY - JOUR T1 - Biodegradation of metal citrate complexes and implications for toxic-metal mobility AN - 13711997; S199342380 AB - A citrate-metabolizing bacterium (Pseudomonas fluorescens) isolated from the leachate of a low-level radioactive waste disposal site was grown in a defined medium with a metal citrate complex as the predominant species. High pressure liquid chromatographic analysis of citric acid, atomic absorption spectroscopic analysis of metals and spectrophotometric or inductively coupled plasma mass spectrometric analysis of uranium showed that bidentate mononuclear complexes of calcium, iron(III) and nickel were readily degraded. The tridentate mononuclear complexes of cadmium, copper and lead were completely resistant to degradation, while the degradation rate for the ferrous tridentate complex depended on the rate of conversion to the more hydrolysed form of the ferric complex which was accelerated by the presence of the bacterium. Uranium formed a binuclear complex which was not degraded but formed a polynuclear 2:3 complex in the presence of excess citrate. Biodegradability of metal citrate complexes appeared to depend on the presence of a free hydroxyl group from the citric acid molecule, and lack of degradation was not due to toxicity. Citric acid could facilitate the migration of toxic metals and radionuclides from disposal sites by forming stable complexes that resisted biodegradation. JF - Nature AU - Francis, A J AU - Dodge, C J AU - Gillow, J B AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1992 PY - 1992 DA - 1992 SP - 140 EP - 142 VL - 356 IS - 6365 SN - 0028-0836, 0028-0836 KW - Analysis KW - Citrate KW - Media KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13711997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Biodegradation+of+metal+citrate+complexes+and+implications+for+toxic-metal+mobility&rft.au=Francis%2C+A+J%3BDodge%2C+C+J%3BGillow%2C+J+B&rft.aulast=Francis&rft.aufirst=A&rft.date=1992-01-01&rft.volume=356&rft.issue=6365&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Carbon budget for the mid-slope depocenter of the Middle Atlantic Bight; a test of the shelf export hypothesis AN - 52679072; 1997-065686 JF - Eos, Transactions, American Geophysical Union AU - Anderson, R F AU - Biscaye, P E AU - Rowe, G T AU - Kemp, P AU - Trumbore, S E AU - Anonymous Y1 - 1991/12// PY - 1991 DA - December 1991 SP - 87 PB - American Geophysical Union, Washington, DC VL - 72 IS - 51, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - sediment-water interface KW - continental slope KW - isotopes KW - marine transport KW - Holocene KW - Cenozoic KW - marine sediments KW - radioactive isotopes KW - dates KW - mass balance KW - carbon KW - sediments KW - absolute age KW - organic carbon KW - Middle Atlantic Bight KW - geochemistry KW - organic materials KW - Northwest Atlantic KW - inner slope KW - carbonate sediments KW - Quaternary KW - sediment transport KW - Eastern U.S. KW - geochemical cycle KW - organic compounds KW - biogenic processes KW - slope environment KW - marine environment KW - continental shelf KW - C-14 KW - upper Holocene KW - North Atlantic KW - Atlantic Ocean KW - 24:Quaternary geology KW - 02C:Geochemistry of rocks, soils, and sediments KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52679072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Carbon+budget+for+the+mid-slope+depocenter+of+the+Middle+Atlantic+Bight%3B+a+test+of+the+shelf+export+hypothesis&rft.au=Anderson%2C+R+F%3BBiscaye%2C+P+E%3BRowe%2C+G+T%3BKemp%2C+P%3BTrumbore%2C+S+E%3BAnonymous&rft.aulast=Anderson&rft.aufirst=R&rft.date=1991-12-01&rft.volume=72&rft.issue=51%2C+Suppl.&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 1992 ocean sciences meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - absolute age; Atlantic Ocean; biogenic processes; C-14; carbon; carbonate sediments; Cenozoic; continental shelf; continental slope; dates; Eastern U.S.; geochemical cycle; geochemistry; Holocene; inner slope; isotopes; marine environment; marine sediments; marine transport; mass balance; Middle Atlantic Bight; North Atlantic; Northwest Atlantic; organic carbon; organic compounds; organic materials; Quaternary; radioactive isotopes; sediment transport; sediment-water interface; sediments; slope environment; United States; upper Holocene ER - TY - JOUR T1 - Boron neutron capture therapy of a murine melanoma with p-boronophenylalanine: dose-response analysis using a morbidity index. AN - 72461892; 1947013 AB - Boron-10 concentrations of 20 or 40 micrograms/g were attained in mouse B16 melanomas following one or two intragastric doses of p-boronophenylalanine (750 mg/kg body weight per dose), respectively. Tumor-to-normal-tissue (blood, muscle) boron concentration ratios were 4:1-6:1. The efficacy of boron neutron capture irradiation was monitored using the Wilcoxon two-sample test in conjunction with a system of ranking outcomes of different therapies that compared living mice and mice sacrificed because of excessive tumor growth concomitantly. Median survivals were extended progressively as radiation doses were increased up to 38.7 gray-equivalent (gray X relative biological effectiveness), with one of five and one of six tumors cured in each of the two highest dose groups, respectively. When comparable tumor inhibitory doses of 250-kVp X rays were used to treat these tumors, instead of the transient erythema and edema that resulted from boron neutron capture therapy, there resulted irreversible muscle necrosis in the irradiated zone and atrophy of the foot distal to the irradiated zone. The improvement in treatment outcome with boron neutron capture therapy is attributable to unprecedented tumor-to-normal-tissue radiation dose ratios of approximately 2.8 to 3.6. JF - Radiation research AU - Coderre, J A AU - Slatkin, D N AU - Micca, P L AU - Ciallella, J R AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1991/11// PY - 1991 DA - November 1991 SP - 177 EP - 185 VL - 128 IS - 2 SN - 0033-7587, 0033-7587 KW - Boron Compounds KW - 0 KW - Radiation-Sensitizing Agents KW - Phenylalanine KW - 47E5O17Y3R KW - 4-boronophenylalanine KW - UID84303EL KW - Index Medicus KW - Space life sciences KW - Animals KW - X-Ray Therapy KW - Radiotherapy Dosage KW - Mice KW - Dose-Response Relationship, Radiation KW - Neutrons KW - Phenylalanine -- analogs & derivatives KW - Melanoma, Experimental -- radiotherapy KW - Phenylalanine -- therapeutic use KW - Melanoma, Experimental -- pathology KW - Boron Compounds -- therapeutic use KW - Radiation-Sensitizing Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72461892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Boron+neutron+capture+therapy+of+a+murine+melanoma+with+p-boronophenylalanine%3A+dose-response+analysis+using+a+morbidity+index.&rft.au=Coderre%2C+J+A%3BSlatkin%2C+D+N%3BMicca%2C+P+L%3BCiallella%2C+J+R&rft.aulast=Coderre&rft.aufirst=J&rft.date=1991-11-01&rft.volume=128&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-29 N1 - Date created - 1991-11-29 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - A different perception of the linear, nonthreshold hypothesis for low-dose irradiation. AN - 72156006; 1924328 AB - Two equally useful dosimetric quantities, both of which are called dose, are used in toxicology. With radiation measurement, only one--the energy per unit mass D--is called dose. The other--the total energy in the irradiated system--is here distinguished from D by assigning it the name collective energy, epsilon. The collective energy is a more complete statement of dose because it is the product of the energy concentration D and the mass irradiated m. Especially in radioepidemiology, in which epsilon is the total energy imparted to all persons irradiated, the quantity m must be specified because it is situation specific and thus highly variable. At present, radioepidemiological dose-response curves are given only in terms of the toxicological model--i.e., the fraction (probability) of radiation-attributable cancers occurring as a function of D. Because this relation does not involve the number of persons at each value of D, it fosters the illusion that any dose, no matter how small, can result in cancer. However, we show that if the dose-response relationship is expressed in terms of the absolute number of attributable cancers as a function of epsilon, cancer occurs, on average, only if the collective energy exceeds a relatively large minimum value, the magnitude of which will be estimated. Therefore, we conclude that the nonthreshold aspect of the linear hypothesis is misleading and quite probably invalid. For example, in or around a facility in which exposure of humans to relatively low values of D occurs, attributable cancers are most unlikely to appear unless the epsilon to the irradiated population exceeds this minimum value. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Bond, V P AU - Benary, V AU - Sondhaus, C A AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1991/10/01/ PY - 1991 DA - 1991 Oct 01 SP - 8666 EP - 8670 VL - 88 IS - 19 SN - 0027-8424, 0027-8424 KW - Index Medicus KW - Radiation Dosage KW - Humans KW - Radiation Monitoring KW - Neoplasms, Radiation-Induced -- etiology KW - Leukemia, Radiation-Induced -- etiology KW - Dose-Response Relationship, Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72156006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=A+different+perception+of+the+linear%2C+nonthreshold+hypothesis+for+low-dose+irradiation.&rft.au=Bond%2C+V+P%3BBenary%2C+V%3BSondhaus%2C+C+A&rft.aulast=Bond&rft.aufirst=V&rft.date=1991-10-01&rft.volume=88&rft.issue=19&rft.spage=8666&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-31 N1 - Date created - 1991-10-31 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Radiat Res Suppl. 1985;8:S52-7 [3867089] Health Phys. 1990 Jul;59(1):35-48 [2358358] Radiat Res. 1989 Jun;118(3):502-24 [2727272] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Severity of organ injury as a predictor of acute mortality for disparate patterns of absorbed dose distribution. AN - 72151278; 1924756 AB - Nonuniform distribution of absorbed dose is frequently encountered in the irradiated mammal; the degree of nonuniform distribution is generally more severe as the size of the animal increases and the energy or penetrating power of the radiation decreases. However, acute mortality under these conditions, e.g., from the hematopoietic syndrome, appears not to be consistently predictable from the dose at any given location or locations within the animal. It is thus reasonable to seek a biological quantity that may be adequate for this purpose. Accordingly, it was postulated that, in animals dying from the bone marrow syndrome, survival is determined by the total number of viable stem cells remaining in the entire body, independent of their distribution. To test this hypothesis, the LD50/30 value for mice exposed to nonuniform irradiation of varying degrees of severity was obtained, as was that for mice receiving uniform total-body irradiation. The distribution of bone marrow in transverse segments of tissue along the spinal axis was determined, as was the dose to each of the segments. The data were analyzed by multiplying, for each segment, the fraction of stem cells in the fraction of cells surviving, as determined from the dose and a survival curve for stem cells determined separately. The sum of these products yielded the surviving number of stem cells in the total mouse, for both the uniformly and nonuniformly exposed animals. The surviving fraction was found to differ by no more than 20%; this was taken to be reasonable evidence that, based on the number of surviving stem cells, it is possible to predict the mortality rate for both uniform and markedly nonuniform irradiation. JF - Radiation research AU - Bond, V P AU - Carsten, A L AU - Bullis, J AU - Roth, S P AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - S9 EP - 11 VL - 128 IS - 1 Suppl SN - 0033-7587, 0033-7587 KW - Cesium Radioisotopes KW - 0 KW - Index Medicus KW - Space life sciences KW - Animals KW - Prognosis KW - Mice KW - Dose-Response Relationship, Radiation KW - Radiation Injuries, Experimental -- mortality KW - Cell Survival -- radiation effects KW - Hematopoietic Stem Cells -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72151278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Severity+of+organ+injury+as+a+predictor+of+acute+mortality+for+disparate+patterns+of+absorbed+dose+distribution.&rft.au=Bond%2C+V+P%3BCarsten%2C+A+L%3BBullis%2C+J%3BRoth%2C+S+P&rft.aulast=Bond&rft.aufirst=V&rft.date=1991-10-01&rft.volume=128&rft.issue=1+Suppl&rft.spage=S9&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-07 N1 - Date created - 1991-11-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Increased lung permeability following long-term use of free-base cocaine (crack). AN - 72120430; 1914604 AB - The clearance of inhaled 99mTc DTPA aerosol from the lungs is used as an index of lung epithelial permeability. Using the radioaerosol method, we investigated the effects of long-term "crack" (free-base cocaine) inhalation on lung permeability in 23 subjects. Eighteen control subjects (12 nonsmokers and 6 cigarette smokers) with no history of drug use were also studied. Subjects inhaled approximately 150 muCi (approximately 5.6 MBq) of 99mTc DTPA aerosol and quantitative gamma camera images of the lungs were acquired at 1-min increments for 25 minutes. Regions of interest (ROIs) were selected to include the following: (1) both lungs; (2) each individual lung; and (3) the upper, middle, and lower thirds of each lung. 99mTc DTPA lung clearance was determined from the slopes of the respective time-activity plots for the different RIOs. Radioaerosol clearance half-times (T1/2) for the seven nonsmoking crack users (61.5 +/- 18.3 minutes) were longer than for the seven cigarette-smoking crack users (27.9 +/- 16.9 minutes) and nine cigarette-smoking crack plus marijuana users (33.5 +/- 21.6 minutes). T1/2 for the nonsmoking crack users was significantly shorter (p less than 0.001) than for the nonsmoking control group (123.8 +/- 28.7 minutes). T1/2 for the cigarette-smoking drug users was similar to that of the cigarette-smoking control group (33.1 +/- 17.8 minutes), suggesting a similar mechanism of damage from the smoke of crack and tobacco. From these groups, one nonsmoker and 11 cigarette smokers displayed biexponential 99mTc DTPA clearances, indicative of greater lung injury than found in the usual cases of monoexponential clearance. The upper lungs of all crack users groups cleared faster than the lower lungs. The faster and biexponential clearance properties of inhaled 99mTc DTPA aerosol were the principal functional abnormalities found in all the drug users. In contrast, 19 of 23 crack users had normal spirometry and gas exchange. These results indicate that 99mTc DTPA may provide a sensitive and useful assay to evaluate the physiologic effects of cocaine inhalation in the lung. JF - Chest AU - Susskind, H AU - Weber, D A AU - Volkow, N D AU - Hitzemann, R AD - Clinical Research Center, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1991/10// PY - 1991 DA - October 1991 SP - 903 EP - 909 VL - 100 IS - 4 SN - 0012-3692, 0012-3692 KW - Crack Cocaine KW - 0 KW - Technetium Tc 99m Pentetate KW - VW78417PU1 KW - Abridged Index Medicus KW - Index Medicus KW - Smoking -- physiopathology KW - Plants, Toxic KW - Spirometry KW - Humans KW - Adult KW - Tobacco KW - Middle Aged KW - Capillary Permeability -- drug effects KW - Pulmonary Gas Exchange -- physiology KW - Radionuclide Imaging KW - Substance-Related Disorders -- physiopathology KW - Lung -- diagnostic imaging KW - Crack Cocaine -- adverse effects KW - Lung -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72120430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Increased+lung+permeability+following+long-term+use+of+free-base+cocaine+%28crack%29.&rft.au=Susskind%2C+H%3BWeber%2C+D+A%3BVolkow%2C+N+D%3BHitzemann%2C+R&rft.aulast=Susskind&rft.aufirst=H&rft.date=1991-10-01&rft.volume=100&rft.issue=4&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-11-15 N1 - Date created - 1991-11-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - A history of boron neutron capture therapy of brain tumours. Postulation of a brain radiation dose tolerance limit. AN - 72070523; 1884169 AB - Boron neutron capture therapy (BNCT) is a form of radiation therapy mediated by the short-range (less than 10 microns) energetic alpha (4He) and lithium-7 (7Li) ionizing particles that result from the prompt disintegration by slow neutrons of the stable (nonradioactive) nucleus boron-10 (10B). Recent advances in radiobiological and toxicological evaluation of tumour-affinitive boron-containing drugs and in optimization of the energies of neutrons in the incident beam have spurred interest in BNCT. This article presents a history of BNCT that emphasizes studies in the USA. A new dosimetric analysis of the 1959-1961 clinical trials of BNCT at Brookhaven National Laboratory is also presented. This analysis yields an acute radiation dose tolerance limit estimate of approximately 10 Gy-Eq to the capillary endothelium of human basal ganglia from BNCT. (Gy-Eq: Gray-equivalent, or relative biological effectiveness of a radiation component multiplied by the physical dose of the component (Gy), summed over the component kinds of radiation.) JF - Brain : a journal of neurology AU - Slatkin, D N AD - Medical Research Center, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 1609 EP - 1629 VL - 114 ( Pt 4) SN - 0006-8950, 0006-8950 KW - Isotopes KW - 0 KW - Boron KW - N9E3X5056Q KW - Abridged Index Medicus KW - Index Medicus KW - History of medicine KW - History, 20th Century KW - Humans KW - Neutrons KW - Technology, Radiologic -- history KW - Brain Neoplasms -- radiotherapy KW - Boron -- therapeutic use KW - Radiation Tolerance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72070523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%3A+a+journal+of+neurology&rft.atitle=A+history+of+boron+neutron+capture+therapy+of+brain+tumours.+Postulation+of+a+brain+radiation+dose+tolerance+limit.&rft.au=Slatkin%2C+D+N&rft.aulast=Slatkin&rft.aufirst=D&rft.date=1991-08-01&rft.volume=114+%28+Pt+4%29&rft.issue=&rft.spage=1609&rft.isbn=&rft.btitle=&rft.title=Brain+%3A+a+journal+of+neurology&rft.issn=00068950&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-10-10 N1 - Date created - 1991-10-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Imaging of cocaine-induced global and regional myocardial ischemia. AN - 72030711; 1869981 AB - Severe and often fatal cardiac complications have been reported in cocaine users with narrowed coronary arteries caused by atherosclerosis as well as in young adults with normal coronaries. We have found that in normal dogs cocaine induces severe temporary hypoperfusion of the left ventricle as indicated by a significantly lower 201Tl concentration compared to the baseline state. The most significant decrease in uptake occurred 5 min after injection and was more pronounced in the septal and apical segments. Following intravenous administration of cocaine, instead of gradual disappearance of 201Tl from the left ventricle, there was continuous increase in 201Tl concentration in the left ventricle. These imaging experiments indicate that the deleterious effects of cocaine on the heart are probably due to spasm of the coronaries and decreased myocardial perfusion. Since spasm of the large subpericardial vessels does not seem to explain the magnitude of the increased coronary resistance and decreased coronary flow after cocaine as described in the literature, it is suggested that microvascular spasm of smaller vessels plays a major role in the temporary decrease in perfusion. The data may also suggest that severe temporary myocardial ischemia is probably the initiating factor for the cardiac complications induced by cocaine. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Oster, Z H AU - Som, P AU - Wang, G J AU - Weber, D A AD - Brookhaven National Laboratory, Medical Department, Upton, New York 11973. Y1 - 1991/08// PY - 1991 DA - August 1991 SP - 1569 EP - 1572 VL - 32 IS - 8 SN - 0161-5505, 0161-5505 KW - Thallium Radioisotopes KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Ventricular Function, Left -- drug effects KW - Animals KW - Electrocardiography KW - Dogs KW - Female KW - Radionuclide Imaging KW - Heart -- diagnostic imaging KW - Coronary Vasospasm -- chemically induced KW - Coronary Disease -- chemically induced KW - Coronary Vasospasm -- diagnostic imaging KW - Cocaine -- toxicity KW - Coronary Disease -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72030711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Imaging+of+cocaine-induced+global+and+regional+myocardial+ischemia.&rft.au=Oster%2C+Z+H%3BSom%2C+P%3BWang%2C+G+J%3BWeber%2C+D+A&rft.aulast=Oster&rft.aufirst=Z&rft.date=1991-08-01&rft.volume=32&rft.issue=8&rft.spage=1569&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-17 N1 - Date created - 1991-09-17 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Controlling basal expression in an inducible T7 expression system by blocking the target T7 promoter with lac repressor. AN - 80532658; 1902522 AB - Effects of placing a lac operator at different positions relative to a promoter for bacteriophage T7 RNA polymerase were tested. Transcription can be strongly repressed by lac repressor bound to an operator centered 15 base-pairs downstream from the RNA start, but T7 RNA polymerase initiates transcription very actively from this T7lac promoter-operator combination in the absence of repressor, or in the presence of repressor plus inducer. Sequence changes in the transcribed region were found to make transcription from some T7 promoters, including the T7lac promoter, more sensitive to inhibition by T7 lysozyme. The pET-10 and pET-11 series of plasmid vectors have been constructed to allow target genes to be placed under control of the T7lac promoter and to be expressed in BL21(DE3) or HMS174(DE3), which carry an inducible gene for T7 RNA polymerase. These vectors carry a lacI gene that provides enough lac repressor to repress both the T7lac promoter in the multicopy vectors and the chromosomal gene for T7 RNA polymerase, which is controlled by the lacUV5 promoter. Very low basal expression of target genes is achieved, but the usual high levels of expression are obtained upon induction. Addition of T7 lysozyme can reduce basal expression even further and still allow high levels of expression upon induction. Genes that are very toxic to Escherichia coli can be maintained and expressed in this system. JF - Journal of molecular biology AU - Dubendorff, J W AU - Studier, F W AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1991/05/05/ PY - 1991 DA - 1991 May 05 SP - 45 EP - 59 VL - 219 IS - 1 SN - 0022-2836, 0022-2836 KW - Oligonucleotide Probes KW - 0 KW - RNA, Viral KW - Repressor Proteins KW - DNA-Directed RNA Polymerases KW - EC 2.7.7.6 KW - beta-Galactosidase KW - EC 3.2.1.23 KW - Index Medicus KW - Protein Biosynthesis KW - Base Sequence KW - beta-Galactosidase -- metabolism KW - Gene Expression Regulation, Viral KW - DNA-Directed RNA Polymerases -- metabolism KW - Restriction Mapping KW - Molecular Sequence Data KW - Gene Expression KW - beta-Galactosidase -- genetics KW - Transcription, Genetic KW - RNA, Viral -- genetics KW - Plasmids KW - Promoter Regions, Genetic KW - Escherichia coli -- metabolism KW - T-Phages -- metabolism KW - Repressor Proteins -- metabolism KW - T-Phages -- genetics KW - Escherichia coli -- genetics KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80532658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Controlling+basal+expression+in+an+inducible+T7+expression+system+by+blocking+the+target+T7+promoter+with+lac+repressor.&rft.au=Dubendorff%2C+J+W%3BStudier%2C+F+W&rft.aulast=Dubendorff&rft.aufirst=J&rft.date=1991-05-05&rft.volume=219&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-06 N1 - Date created - 1991-06-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Use of bacteriophage T7 lysozyme to improve an inducible T7 expression system. AN - 80531828; 2023259 AB - Bacteriophage T7 lysozyme, a natural inhibitor of T7 RNA polymerase, can reduce basal activity from an inducible gene for T7 RNA polymerase and allow relatively toxic genes to be established in the same cell under control of a T7 promoter. Low levels of T7 lysozyme supplied by plasmids pLysS or pLysL, which are compatible with the pET vectors for expressing genes from a T7 promoter, are sufficient to stabilize many target plasmids and yet allow high levels of target protein to be produced upon induction of T7 RNA polymerase. Higher levels of lysozyme supplied by plasmids pLysE or pLysH reduce the fully induced activity of T7 RNA polymerase such that induced cells can continue to grow and produce innocuous target proteins indefinitely. Different configurations of the expression system can maintain several different steady-state levels of target gene expression. The presence of T7 lysozyme has the further advantage of facilitating the lysis of cells in preparing extracts for purification of target gene products. JF - Journal of molecular biology AU - Studier, F W AD - Biology Department, Brookhaven National Laboratory Upton, NY 11973. Y1 - 1991/05/05/ PY - 1991 DA - 1991 May 05 SP - 37 EP - 44 VL - 219 IS - 1 SN - 0022-2836, 0022-2836 KW - DNA-Directed RNA Polymerases KW - EC 2.7.7.6 KW - Muramidase KW - EC 3.2.1.17 KW - Index Medicus KW - Promoter Regions, Genetic KW - Genetic Vectors KW - Gene Expression KW - Cloning, Molecular -- methods KW - Plasmids KW - T-Phages -- enzymology KW - Muramidase -- genetics KW - T-Phages -- genetics KW - Escherichia coli -- genetics KW - Genes, Viral KW - Escherichia coli -- enzymology KW - Muramidase -- metabolism KW - DNA-Directed RNA Polymerases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80531828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Use+of+bacteriophage+T7+lysozyme+to+improve+an+inducible+T7+expression+system.&rft.au=Studier%2C+F+W&rft.aulast=Studier&rft.aufirst=F&rft.date=1991-05-05&rft.volume=219&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-06 N1 - Date created - 1991-06-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Changes in brain glucose metabolism in cocaine dependence and withdrawal. AN - 80519588; 2018164 AB - OBJECTIVEThe authors investigated changes in brain function associated with cocaine dependence and withdrawal to provide clues regarding the processes that lead to the uncontrollable self-administration of cocaine.METHODThey measured regional brain metabolism with [18F]-fluorodeoxyglucose (FDG) and positron emission tomography in 15 outpatients with the diagnosis of cocaine abuse and 17 normal comparison subjects. Ten of the patients were studied less than 1 week after they had last had cocaine, and five were studied 2-4 weeks after withdrawal.RESULTSPatients studied within 1 week of cocaine withdrawal but not those studied within 2-4 weeks of cocaine withdrawal had higher levels of global brain metabolism as well as higher levels of regional brain metabolism in the basal ganglia and orbitofrontal cortex than did normal subjects, probably as a consequence of less brain dopamine activity. There was also a significant relationship between the number of days since cocaine withdrawal and regional brain glucose metabolism in the orbitofrontal cortex and in the basal ganglia, and the correlations between cocaine craving and metabolic activity were significant in the prefrontal cortex and the orbitofrontal cortex.CONCLUSIONSAlthough the time-dependent fall in metabolic activity suggests that the higher metabolic activity observed less than a week after cocaine withdrawal may represent a nonspecific expression of drug withdrawal, the selectivity of changes in glucose metabolism for the basal ganglia and for the orbitofrontal cortex suggests that the regional metabolic changes seen in cocaine abusers during detoxification are related to changes in brain dopamine activity. JF - The American journal of psychiatry AU - Volkow, N D AU - Fowler, J S AU - Wolf, A P AU - Hitzemann, R AU - Dewey, S AU - Bendriem, B AU - Alpert, R AU - Hoff, A AD - Medical Department Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 621 EP - 626 VL - 148 IS - 5 SN - 0002-953X, 0002-953X KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Deoxyglucose KW - 9G2MP84A8W KW - Cocaine KW - I5Y540LHVR KW - Glucose KW - IY9XDZ35W2 KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Regression Analysis KW - Humans KW - Dopamine -- metabolism KW - Ambulatory Care KW - Adult KW - Deoxyglucose -- analogs & derivatives KW - Frontal Lobe -- metabolism KW - Occipital Lobe -- metabolism KW - Tomography, Emission-Computed KW - Adolescent KW - Time Factors KW - Male KW - Basal Ganglia -- metabolism KW - Deoxyglucose -- metabolism KW - Substance-Related Disorders -- diagnosis KW - Substance Withdrawal Syndrome -- metabolism KW - Substance Withdrawal Syndrome -- etiology KW - Substance Withdrawal Syndrome -- diagnosis KW - Glucose -- metabolism KW - Brain -- metabolism KW - Substance-Related Disorders -- metabolism KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80519588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Changes+in+brain+glucose+metabolism+in+cocaine+dependence+and+withdrawal.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWolf%2C+A+P%3BHitzemann%2C+R%3BDewey%2C+S%3BBendriem%2C+B%3BAlpert%2C+R%3BHoff%2C+A&rft.aulast=Volkow&rft.aufirst=N&rft.date=1991-05-01&rft.volume=148&rft.issue=5&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-20 N1 - Date created - 1991-05-20 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: Am J Psychiatry. 1991 Dec;148(12):1759-60 [1957952] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - The high level vibration test program AN - 50395443; 1992-064364 JF - NUREG/CR (United States. Nuclear Regulatory Commission) AU - Park, Y J AU - Curreri, J R AU - Hofmayer, C H Y1 - 1991/05// PY - 1991 DA - May 1991 SP - 265 PB - U. S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, Washington, DC SN - 0278-1670, 0278-1670 KW - United States KW - experimental studies KW - Far East KW - data processing KW - effects KW - seismic response KW - pipelines KW - models KW - engineering geology KW - cracks KW - vibration KW - nuclear facilities KW - Asia KW - plasticity KW - earthquakes KW - Japan KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50395443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Park%2C+Y+J%3BCurreri%2C+J+R%3BHofmayer%2C+C+H&rft.aulast=Park&rft.aufirst=Y&rft.date=1991-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+high+level+vibration+test+program&rft.title=The+high+level+vibration+test+program&rft.issn=02781670&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1992-01-01 N1 - Number of references - 3 N1 - PubXState - DC N1 - Document feature - illus. incl. 35 tables, sects. N1 - SuppNotes - Final report; includes 11 appendices N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; cracks; data processing; earthquakes; effects; engineering geology; experimental studies; Far East; Japan; models; nuclear facilities; pipelines; plasticity; seismic response; United States; vibration ER - TY - JOUR T1 - Activities of the enantiomers of cocaine and some related compounds as substrates and inhibitors of plasma butyrylcholinesterase. AN - 80491554; 2009099 AB - The behaviors of the enantiomers of cocaine (benzoylecgonine methyl ester) and related compounds with butyrylcholinesterase (BChE; EC 3.1.1.8) were investigated spectrophotometrically at 235 nm. The unnatural enantiomer, (+)-cocaine, was hydrolyzed by BChE (extinction coefficient 6.7 L.mmol-1.cm-1) at about half the rate of benzoylcholine, but over 2000 times faster than naturally occurring (-)-cocaine. This rapid hydrolysis of (+)-cocaine may account, in part, for its pharmacological inactivity. (+)-Norcocaine, (+)-benzoylecgonine, (-)-psi-cocaine and tropacocaine were also substrates for BChE. Hydrolysis of (+)-cocaine was sensitive to several standard inhibitors of BChE, including those of competitive, carbamate and organophosphorus classes. Although (-)-cocaine was a poor substrate for debenzoylation, it was a fairly good competitive inhibitor (Ki approximately 10 microM) of the hydrolysis of other substrates. The cocaine metabolites (-)-norcocaine, (-)-benzoylecgonine and (-)-ecgonine methyl ester inhibited BChE with Ki values of 15, 76 and 1300 microM, respectively. (+)-psi-Cocaine had Ki = 3 microM, p-Nitro and p-fluoro derivatives of cocaine and analogs with phenyl and p-fluorophenyl groups in place of the benzoyl ester linkage (WIN 35,065-2 and WIN 35,428) inhibited BChE comparably to (-)-cocaine itself. Both cocaine enantiomers were weak inhibitors of acetylcholinesterase (AChE; EC 3.1.1.7) from human erythrocytes with similar Ki values (160-170 microM). Although it is unlikely that the inhibition of BChE is an important factor in the subjective effects of cocaine, it may have implications for the toxicity of cocaine to the fetus, since BChE appears in the development of the central nervous system before AChE, and has been suggested to function as an embryonic acetylcholinesterase. JF - Biochemical pharmacology AU - Gatley, S J AD - Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1991/04/15/ PY - 1991 DA - 1991 Apr 15 SP - 1249 EP - 1254 VL - 41 IS - 8 SN - 0006-2952, 0006-2952 KW - Cholinesterase Inhibitors KW - 0 KW - Butyrylcholinesterase KW - EC 3.1.1.- KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Stereoisomerism KW - Kinetics KW - Humans KW - In Vitro Techniques KW - Binding, Competitive KW - Horses KW - Structure-Activity Relationship KW - Cocaine -- pharmacology KW - Butyrylcholinesterase -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80491554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Activities+of+the+enantiomers+of+cocaine+and+some+related+compounds+as+substrates+and+inhibitors+of+plasma+butyrylcholinesterase.&rft.au=Gatley%2C+S+J&rft.aulast=Gatley&rft.aufirst=S&rft.date=1991-04-15&rft.volume=41&rft.issue=8&rft.spage=1249&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-04-30 N1 - Date created - 1991-04-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Do pyrimidine dimer yields correlate with erythema induction in human skin irradiated in situ with ultraviolet light (275-365 nm)? AN - 80702996; 1857749 AB - Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad-band UV-B (290-320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV-B sensitivity (low minimal erythema dose) than in subjects of low UV-B sensitivity [Freeman et al. (1986) J. Invest. Dermatol., 86, 34-36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275-365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength. JF - Photochemistry and photobiology AU - Hacham, H AU - Freeman, S E AU - Gange, R W AU - Maytum, D J AU - Sutherland, J C AU - Sutherland, B M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1991/04// PY - 1991 DA - April 1991 SP - 559 EP - 563 VL - 53 IS - 4 SN - 0031-8655, 0031-8655 KW - Pyrimidine Dimers KW - 0 KW - Index Medicus KW - Erythema -- etiology KW - Humans KW - Pyrimidine Dimers -- radiation effects KW - Adult KW - Dose-Response Relationship, Radiation KW - Skin -- radiation effects KW - Ultraviolet Rays -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80702996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Do+pyrimidine+dimer+yields+correlate+with+erythema+induction+in+human+skin+irradiated+in+situ+with+ultraviolet+light+%28275-365+nm%29%3F&rft.au=Hacham%2C+H%3BFreeman%2C+S+E%3BGange%2C+R+W%3BMaytum%2C+D+J%3BSutherland%2C+J+C%3BSutherland%2C+B+M&rft.aulast=Hacham&rft.aufirst=H&rft.date=1991-04-01&rft.volume=53&rft.issue=4&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-08-28 N1 - Date created - 1991-08-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Dissolution of ferrites by Clostridium sp. AN - 50337273; 1993-027235 JF - Geomicrobiology Journal AU - Francis, A J AU - Dodge, C J Y1 - 1991/03// PY - 1991 DA - March 1991 SP - 27 EP - 40 PB - Crane, Russak & Co., New York, NY VL - 9 IS - 1 SN - 0149-0451, 0149-0451 KW - thallophytes KW - Clostridium KW - Plantae KW - experimental studies KW - iron oxides KW - biochemistry KW - solutes KW - solution KW - organo-metallics KW - iron KW - ferric iron KW - anaerobic taxa KW - metals KW - bacteria KW - oxides KW - anaerobic environment KW - reduction KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50337273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geomicrobiology+Journal&rft.atitle=Dissolution+of+ferrites+by+Clostridium+sp.&rft.au=Francis%2C+A+J%3BDodge%2C+C+J&rft.aulast=Francis&rft.aufirst=A&rft.date=1991-03-01&rft.volume=9&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Geomicrobiology+Journal&rft.issn=01490451&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 28 N1 - PubXState - NY N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2014-03-14 N1 - CODEN - GEJODG N1 - SubjectsTermNotLitGenreText - anaerobic environment; anaerobic taxa; bacteria; biochemistry; Clostridium; experimental studies; ferric iron; iron; iron oxides; metals; organo-metallics; oxides; Plantae; reduction; solutes; solution; thallophytes ER - TY - JOUR T1 - Cloning, sequencing, and overexpression of genes for ribosomal proteins from Bacillus stearothermophilus. AN - 80361726; 1985969 AB - Although a low resolution model for the arrangement of the proteins of the small and large ribosomal subunits is known, a detailed mechanistic understanding of the function of the ribosome awaits a high resolution structure of its components. While crystals have been obtained of several ribosomal proteins from Bacillus stearothermophilus, determination of atomic resolution structures of these proteins is impeded by the difficulty of obtaining large amounts of native proteins for crystallographic or NMR studies. We describe here the cloning and overexpression in Escherichia coli of the genes for ribosomal proteins S5, L6, L9, and L18 from B. stearothermophilus. S5 is extremely toxic to E. coli when overexpressed, and we have taken advantage of a new tightly regulated expression system to obtain high yields (more than 100 mg of pure protein/liter of culture) of this protein. The B. stearothermophilus S5 produced in E. coli crystallizes, and the crystals are identical to those obtained from the native protein. The crystals diffract to 2-A resolution. JF - The Journal of biological chemistry AU - Ramakrishnan, V AU - Gerchman, S E AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1991/01/15/ PY - 1991 DA - 1991 Jan 15 SP - 880 EP - 885 VL - 266 IS - 2 SN - 0021-9258, 0021-9258 KW - DNA, Bacterial KW - 0 KW - Ribosomal Proteins KW - Index Medicus KW - Polymerase Chain Reaction KW - Base Sequence KW - Electrophoresis, Polyacrylamide Gel KW - DNA, Bacterial -- genetics KW - Molecular Sequence Data KW - Escherichia coli -- genetics KW - Amino Acid Sequence KW - Cloning, Molecular KW - Gene Expression Regulation, Bacterial KW - Genes, Bacterial KW - Ribosomal Proteins -- genetics KW - Geobacillus stearothermophilus -- metabolism KW - Geobacillus stearothermophilus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80361726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Cloning%2C+sequencing%2C+and+overexpression+of+genes+for+ribosomal+proteins+from+Bacillus+stearothermophilus.&rft.au=Ramakrishnan%2C+V%3BGerchman%2C+S+E&rft.aulast=Ramakrishnan&rft.aufirst=V&rft.date=1991-01-15&rft.volume=266&rft.issue=2&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-12 N1 - Date created - 1991-02-12 N1 - Date revised - 2017-02-17 N1 - Genetic sequence - M57623; GENBANK; M57624; M60204; M63262; M60203; M60205; M60206; M62780; M57621; M57622 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Trends in quantitative cancer risk assessment. AN - 80614467; 2050076 AB - Quantitative cancer risk assessment is a dynamic field, more closely coupled to rapidly advancing biomedical research than ever before. Six areas of change and growth are identified: expansion from models of cancer initiation to a more complete picture of the total carcinogenic process; trend from curve-fitting to biologically based models; movement from upperbound estimates to best estimates, with a more complete treatment of uncertainty; increased consideration of the role of susceptibility; growing development of expert systems and decision support systems; and emerging importance of risk communication. JF - Environmental health perspectives AU - Morris, S C AD - Biomedical and Environmental Assessment Division, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 297 EP - 298 VL - 90 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Risk KW - Disease Susceptibility KW - Humans KW - Models, Statistical KW - Models, Biological KW - Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80614467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Trends+in+quantitative+cancer+risk+assessment.&rft.au=Morris%2C+S+C&rft.aulast=Morris&rft.aufirst=S&rft.date=1991-01-01&rft.volume=90&rft.issue=&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-25 N1 - Date created - 1991-07-25 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039] Risk Anal. 1988 Sep;8(3):383-92 [3201016] Environ Health Perspect. 1991 Jan;90:215-22 [2050064] Environ Health Perspect. 1991 Jan;90:223-7 [2050065] Environ Health Perspect. 1991 Jan;90:293-6 [2050075] Environ Health Perspect. 1991 Jan;90:247-54 [2050068] Environ Health Perspect. 1991 Jan;90:271-7 [2050072] Environ Health Perspect. 1991 Jan;90:279-85 [2050073] Environ Health Perspect. 1991 Jan;90:287-92 [2050074] Environ Health Perspect. 1991 Jan;90:229-38 [2050066] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - A system for simultaneous exposure of small animals to 60-Hz electric and magnetic fields. AN - 80586386; 2039559 AB - Equipment designed for simultaneous exposure of rodents to 60-Hz electric and magnetic fields is described. Three identical systems were constructed, each capable of continuous exposure of 256 rats or 640 mice to a nominal electric field at less than 50 kV/m, and to horizontal and vertical magnetic fields at less than 1 mT. Design features, construction details, and results of various tests of the systems are described. Tests were made: of phase relations between electric and magnetic fields; of uniformity of electric and magnetic fields; of changes across time in electric-field intensity as a result of animals' soiling of cages and various washing routines; of resistance of bedding material during humid and dry conditions; and of acoustic noise due to background, to field-generation equipment, and to air conditioning equipment. The results demonstrated that fields were effectively generated but that significant and troublesome changes in electric-field intensity occurred because of cage-soiling. However, when cages were frequently cleaned, field intensities were consistent from one exposure to another. JF - Bioelectromagnetics AU - Baum, J W AU - Kuehner, A V AU - Benz, R D AU - Carsten, A L AD - Department of Nuclear Energy, Brookhaven National Laboratory, Upton, New York 11973-5000. Y1 - 1991 PY - 1991 DA - 1991 SP - 85 EP - 99 VL - 12 IS - 2 SN - 0197-8462, 0197-8462 KW - Index Medicus KW - Rats KW - Animals KW - Equipment Design KW - Housing, Animal KW - Mice KW - Animals, Laboratory KW - Research Design KW - Female KW - Pregnancy KW - Environmental Exposure KW - Electromagnetic Fields -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80586386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioelectromagnetics&rft.atitle=A+system+for+simultaneous+exposure+of+small+animals+to+60-Hz+electric+and+magnetic+fields.&rft.au=Baum%2C+J+W%3BKuehner%2C+A+V%3BBenz%2C+R+D%3BCarsten%2C+A+L&rft.aulast=Baum&rft.aufirst=J&rft.date=1991-01-01&rft.volume=12&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Bioelectromagnetics&rft.issn=01978462&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-07-03 N1 - Date created - 1991-07-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Positron emission tomography: basic principles and applications in psychiatric research. AN - 80575268; 2035939 JF - Annals of the New York Academy of Sciences AU - Volkow, N D AU - Brodie, J AU - Bendriem, B AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1991 PY - 1991 DA - 1991 SP - 128 EP - 144 VL - 620 SN - 0077-8923, 0077-8923 KW - Index Medicus KW - Mood Disorders -- diagnosis KW - Gamma Cameras KW - Obsessive-Compulsive Disorder -- diagnosis KW - Schizophrenia -- metabolism KW - Alcoholism -- diagnosis KW - Humans KW - Schizophrenia -- diagnosis KW - Obsessive-Compulsive Disorder -- metabolism KW - Alcoholism -- metabolism KW - Research Design KW - Mood Disorders -- metabolism KW - Mental Disorders -- diagnosis KW - Brain -- metabolism KW - Tomography, Emission-Computed -- instrumentation KW - Mental Disorders -- metabolism KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80575268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Positron+emission+tomography%3A+basic+principles+and+applications+in+psychiatric+research.&rft.au=Volkow%2C+N+D%3BBrodie%2C+J%3BBendriem%2C+B&rft.aulast=Volkow&rft.aufirst=N&rft.date=1991-01-01&rft.volume=620&rft.issue=&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-06-26 N1 - Date created - 1991-06-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Role of uracil-DNA glycosylase in mutation avoidance by Streptococcus pneumoniae. AN - 80423561; 1987120 AB - Uracil-DNA glycosylase activity was found in Streptococcus pneumoniae, and the enzyme was partially purified. An ung mutant lacking the activity was obtained by positive selection of cells transformed with a plasmid containing uracil in its DNA. The effects of the ung mutation on mutagenic processes in S. pneumoniae were examined. The sequence of several malM mutations revertible by nitrous acid showed them to correspond to A.T----G.C transitions. This confirmed a prior deduction that nitrous acid action on transforming DNA gave only G.C----A.T mutations. Examination of malM mutant reversion frequencies in ung strains indicated that G.C----A.T mutation rates generally were 10-fold higher than in wild-type strains, presumably owing to lack of repair of deaminated cytosine residues in DNA. No effect of ung on mutation avoidance by the Hex mismatch repair system was observed, which means that uracil incorporation and removal from nascent DNA cannot be solely responsible for producing strand breaks that target nascent DNA for correction after replication. One malM mutation corresponding to an A.T----G.C transition showed a 10-fold-higher spontaneous reversion frequency than other such transitions in a wild-type background. This "hot spot" was located in a directly repeated DNA sequence; it is proposed that transient slippage to the wild-type repeat during replication accounts for the higher reversion frequency. JF - Journal of bacteriology AU - Chen, J D AU - Lacks, S A AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1991/01// PY - 1991 DA - January 1991 SP - 283 EP - 290 VL - 173 IS - 1 SN - 0021-9193, 0021-9193 KW - malM KW - ung KW - Uracil KW - 56HH86ZVCT KW - DNA Glycosylases KW - EC 3.2.2.- KW - N-Glycosyl Hydrolases KW - Uracil-DNA Glycosidase KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Genotype KW - Transformation, Bacterial KW - Base Sequence KW - Base Composition KW - Uracil -- metabolism KW - Molecular Sequence Data KW - Escherichia coli -- genetics KW - Plasmids KW - Streptococcus pneumoniae -- enzymology KW - DNA Repair KW - N-Glycosyl Hydrolases -- genetics KW - N-Glycosyl Hydrolases -- metabolism KW - Mutation KW - Streptococcus pneumoniae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80423561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Role+of+uracil-DNA+glycosylase+in+mutation+avoidance+by+Streptococcus+pneumoniae.&rft.au=Chen%2C+J+D%3BLacks%2C+S+A&rft.aulast=Chen&rft.aufirst=J&rft.date=1991-01-01&rft.volume=173&rft.issue=1&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-02-20 N1 - Date created - 1991-02-20 N1 - Date revised - 2017-02-17 N1 - Gene symbol - malM; ung N1 - SuppNotes - Cited By: J Biol Chem. 1989 Feb 15;264(5):2593-8 [2644266] J Bacteriol. 1984 Jun;158(3):905-9 [6327647] J Bacteriol. 1989 May;171(5):2278-86 [2468646] Science. 1989 Jul 14;245(4914):160-4 [2665076] J Bacteriol. 1989 Oct;171(10):5325-31 [2676972] Gene. 1984 May;28(2):211-9 [6234205] Proc Natl Acad Sci U S A. 1984 Aug;81(16):5189-93 [6089185] Proc Natl Acad Sci U S A. 1985 Jan;82(2):488-92 [3881765] Gene. 1986;41(2-3):153-63 [3011593] J Bacteriol. 1986 Jun;166(3):905-13 [3519585] Microbiol Rev. 1986 Jun;50(2):133-65 [3523187] J Mol Biol. 1986 May 5;189(1):113-30 [3537305] J Mol Biol. 1986 Dec 20;192(4):753-65 [2438417] J Bacteriol. 1987 Sep;169(9):4320-6 [3114239] J Bacteriol. 1988 Jan;170(1):190-6 [3275608] J Bacteriol. 1988 Jan;170(1):197-202 [3275609] Virology. 1962 Apr;16:452-9 [14493621] J Mol Biol. 1965 Mar;11:476-90 [14267270] J Biol Chem. 1977 May 25;252(10):3286-94 [324994] Proc Natl Acad Sci U S A. 1978 Jan;75(1):233-7 [203931] J Biol Chem. 1978 Sep 10;253(17):5877-9 [98523] Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 [388356] Mol Gen Genet. 1980 Apr;178(1):191-201 [6929947] Nature. 1980 Oct 9;287(5782):560-1 [6999365] J Bacteriol. 1981 Feb;145(2):687-95 [6109711] Mol Gen Genet. 1981;181(1):57-62 [6938758] Proc Natl Acad Sci U S A. 1981 Nov;78(11):7028-32 [6273903] Virology. 1970 Mar;40(3):734-44 [4908735] Genetics. 1966 Jan;53(1):207-35 [4379022] J Bacteriol. 1982 May;150(2):692-701 [6279568] J Virol. 1968 Mar;2(3):256-64 [4986906] J Bacteriol. 1973 Apr;114(1):152-63 [4144589] Biochemistry. 1974 Jul 30;13(16):3405-10 [4601435] Proc Natl Acad Sci U S A. 1974 Sep;71(9):3649-53 [4610583] J Biol Chem. 1975 Jun 10;250(11):4060-66 [236309] J Bacteriol. 1975 Jul;123(1):222-32 [237879] J Mol Biol. 1976 Feb 25;101(2):255-75 [4625] Biochemistry. 1976 May 4;15(9):1838-43 [817735] Anal Biochem. 1976 May 7;72:248-54 [942051] Anal Biochem. 1976 Dec;76(2):431-41 [11708] J Biol Chem. 1951 Nov;193(1):265-75 [14907713] J Mol Biol. 1962 Jul;5:119-31 [14461406] J Biol Chem. 1988 Jun 5;263(16):7776-84 [2836397] J Bacteriol. 1989 Oct;171(10):5332-8 [2676973] J Bacteriol. 1989 Oct;171(10):5339-46 [2676974] EMBO J. 1989 Oct;8(10):3121-5 [2555154] J Mol Biol. 1990 Jun 20;213(4):727-38 [2359120] J Bacteriol. 1982 Aug;151(2):750-5 [7047496] Cell. 1982 Jun;29(2):319-28 [6288254] Cell. 1982 Dec;31(2 Pt 1):327-36 [6297760] J Mol Biol. 1983 Jun 5;166(4):557-80 [6345791] J Bacteriol. 1984 Mar;157(3):934-6 [6321445] Genetics. 1989 Jan;121(1):29-36 [2645195] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Use of positron emission tomography to study cocaine in the human brain. AN - 72555388; 1753998 AB - It is feasible to directly image and measure the concentration of different drugs of abuse and their consequences on regional brain function and neurotransmitter activity with PET. Although PET is a relatively new technique, it already is proving to be useful in disclosing the mechanisms of toxicity reinforcement and addition of drugs of abuse. JF - NIDA research monograph AU - Volkow, N D AU - Fowler, J S AU - Wolf, A P AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1991 PY - 1991 DA - 1991 SP - 168 EP - 179 VL - 112 SN - 1046-9516, 1046-9516 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Humans KW - Reinforcement (Psychology) KW - Substance-Related Disorders KW - Brain -- drug effects KW - Tomography, Emission-Computed KW - Cocaine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72555388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Use+of+positron+emission+tomography+to+study+cocaine+in+the+human+brain.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWolf%2C+A+P&rft.aulast=Volkow&rft.aufirst=N&rft.date=1991-01-01&rft.volume=112&rft.issue=&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1992-01-30 N1 - Date created - 1992-01-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Sulphur isotope variations in the atmosphere AN - 50870259; 2007-008857 JF - SCOPE AU - Newman, L AU - Krouse, H R AU - Grinenko, V A A2 - Krouse, H. R. A2 - Grinenko, V. A. Y1 - 1991 PY - 1991 DA - 1991 SP - 133 EP - 176 PB - Island Press, Washington, DC VL - 43 SN - 0271-972X, 0271-972X KW - sulfur dioxide KW - concentration KW - oxygen KW - isotopes KW - clastic sediments KW - isotope ratios KW - human activity KW - grain size KW - background level KW - atmosphere KW - O-18/O-16 KW - stable isotopes KW - S-34/S-32 KW - volcanism KW - dust KW - sediments KW - sulfur KW - aerosols KW - seasonal variations KW - wind transport KW - chemical composition KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50870259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SCOPE&rft.atitle=Sulphur+isotope+variations+in+the+atmosphere&rft.au=Newman%2C+L%3BKrouse%2C+H+R%3BGrinenko%2C+V+A&rft.aulast=Newman&rft.aufirst=L&rft.date=1991-01-01&rft.volume=43&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=SCOPE&rft.issn=0271972X&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 106 N1 - PubXState - DC N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aerosols; atmosphere; background level; chemical composition; clastic sediments; concentration; dust; grain size; human activity; isotope ratios; isotopes; O-18/O-16; oxygen; S-34/S-32; seasonal variations; sediments; stable isotopes; sulfur; sulfur dioxide; volcanism; wind transport ER - TY - JOUR T1 - Case studies and potential applications AN - 50868812; 2007-008860 JF - SCOPE AU - Krouse, H R AU - Grinenko, L N AU - Grinenko, V A AU - Newman, L AU - Forrest, J AU - Nakai, N AU - Tsuji, Y AU - Yatsumimi, T AU - Takeuchi, U AU - Robinson, B W AU - Stewart, M K AU - Gunatilaka, A AU - Chambers, L A AU - Smith, J W AU - Plumb, L A AU - Buzek, F AU - Cerny, J AU - Sramek, J AU - Menon, A G AU - Iyer, G V A AU - Venkatasubramanian, V S AU - Egboka, B E C AU - Irogbenachi, M M AU - Eligwe, C A A2 - Krouse, H. R. A2 - Grinenko, V. A. Y1 - 1991 PY - 1991 DA - 1991 SP - 307 EP - 422 PB - Island Press, Washington, DC VL - 43 SN - 0271-972X, 0271-972X KW - Russian Republic KW - Far East KW - power plants KW - Europe KW - Spencer Gulf KW - Alberta KW - hydrosphere KW - India KW - Central Europe KW - Kuwait KW - Asia KW - sulfate ion KW - Bohemia KW - Kansk Russian Federation KW - atmosphere KW - Shark Bay KW - West Africa KW - Czech Republic KW - S-34/S-32 KW - Canada KW - marine environment KW - biosphere KW - industrial waste KW - Africa KW - Mikawa KW - Aichi Japan KW - waste disposal KW - South Australia KW - USSR KW - United States KW - Nigeria KW - isotopes KW - Western Australia KW - Russian Federation KW - Prague Czech Republic KW - stable isotopes KW - Krasnoyarsk Russian Federation KW - Commonwealth of Independent States KW - Indian Peninsula KW - Australia KW - trace elements KW - soils KW - sulfur dioxide KW - Australasia KW - isotope ratios KW - pollution KW - case studies KW - Czechoslovakia KW - Arabian Peninsula KW - sulfur deposits KW - sulfur KW - Western Canada KW - Honshu KW - Japan KW - 02D:Isotope geochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50868812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SCOPE&rft.atitle=Case+studies+and+potential+applications&rft.au=Krouse%2C+H+R%3BGrinenko%2C+L+N%3BGrinenko%2C+V+A%3BNewman%2C+L%3BForrest%2C+J%3BNakai%2C+N%3BTsuji%2C+Y%3BYatsumimi%2C+T%3BTakeuchi%2C+U%3BRobinson%2C+B+W%3BStewart%2C+M+K%3BGunatilaka%2C+A%3BChambers%2C+L+A%3BSmith%2C+J+W%3BPlumb%2C+L+A%3BBuzek%2C+F%3BCerny%2C+J%3BSramek%2C+J%3BMenon%2C+A+G%3BIyer%2C+G+V+A%3BVenkatasubramanian%2C+V+S%3BEgboka%2C+B+E+C%3BIrogbenachi%2C+M+M%3BEligwe%2C+C+A&rft.aulast=Krouse&rft.aufirst=H&rft.date=1991-01-01&rft.volume=43&rft.issue=&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=SCOPE&rft.issn=0271972X&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 109 N1 - PubXState - DC N1 - Document feature - illus. incl. 53 tables, sketch maps N1 - SuppNotes - This article contains an appendix N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Africa; Aichi Japan; Alberta; Arabian Peninsula; Asia; atmosphere; Australasia; Australia; biosphere; Bohemia; Canada; case studies; Central Europe; Commonwealth of Independent States; Czech Republic; Czechoslovakia; Europe; Far East; Honshu; hydrosphere; India; Indian Peninsula; industrial waste; isotope ratios; isotopes; Japan; Kansk Russian Federation; Krasnoyarsk Russian Federation; Kuwait; marine environment; Mikawa; Nigeria; pollution; power plants; Prague Czech Republic; Russian Federation; Russian Republic; S-34/S-32; Shark Bay; soils; South Australia; Spencer Gulf; stable isotopes; sulfate ion; sulfur; sulfur deposits; sulfur dioxide; trace elements; United States; USSR; waste disposal; West Africa; Western Australia; Western Canada ER - TY - JOUR T1 - Lunar volcanic glasses; trace element abundances in individual spheres using synchrotron X-ray fluorescence AN - 50315711; 1993-037453 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Delano, J W AU - Sutton, S R AU - Smith, J V A2 - Ryder, Graham A2 - Sharpton, Virgil L. Y1 - 1991 PY - 1991 DA - 1991 SP - 311 EP - 312 PB - Lunar and Planetary Science Conference, Houston, TX VL - 22 KW - volatiles KW - X-ray data KW - volcanic rocks KW - glasses KW - Moon KW - magmas KW - igneous rocks KW - X-ray fluorescence data KW - trace elements KW - maria KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50315711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Lunar+volcanic+glasses%3B+trace+element+abundances+in+individual+spheres+using+synchrotron+X-ray+fluorescence&rft.au=Delano%2C+J+W%3BSutton%2C+S+R%3BSmith%2C+J+V&rft.aulast=Delano&rft.aufirst=J&rft.date=1991-01-01&rft.volume=22&rft.issue=&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-second lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 23 N1 - PubXState - TX N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - glasses; igneous rocks; magmas; maria; Moon; trace elements; volatiles; volcanic rocks; X-ray data; X-ray fluorescence data ER - TY - JOUR T1 - Fe-Mn-Mg in plagioclase from lunar basalt and highland samples AN - 50315306; 1993-037447 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Delaney, Jeremy S AU - Sutton, S R A2 - Ryder, Graham A2 - Sharpton, Virgil L. Y1 - 1991 PY - 1991 DA - 1991 SP - 299 EP - 300 PB - Lunar and Planetary Science Conference, Houston, TX VL - 22 KW - silicates KW - alkaline earth metals KW - plagioclase KW - magnesium KW - volcanic rocks KW - Moon KW - igneous rocks KW - differentiation KW - lunar highlands KW - manganese KW - iron KW - partitioning KW - volcanism KW - metals KW - magmas KW - basalts KW - crystallization KW - framework silicates KW - feldspar group KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50315306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Fe-Mn-Mg+in+plagioclase+from+lunar+basalt+and+highland+samples&rft.au=Delaney%2C+Jeremy+S%3BSutton%2C+S+R&rft.aulast=Delaney&rft.aufirst=Jeremy&rft.date=1991-01-01&rft.volume=22&rft.issue=&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-second lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 2 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - alkaline earth metals; basalts; crystallization; differentiation; feldspar group; framework silicates; igneous rocks; iron; lunar highlands; magmas; magnesium; manganese; metals; Moon; partitioning; plagioclase; silicates; volcanic rocks; volcanism ER - TY - JOUR T1 - Computed microtomography (CMT) of the internal structures of rare extraterrestrial objects AN - 50304832; 1993-045442 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Sutton, S R AU - Spanne, P AU - Rivers, M L AU - Jones, K W A2 - Ryder, Graham A2 - Sharpton, Virgil L. Y1 - 1991 PY - 1991 DA - 1991 SP - 1367 EP - 1368 PB - Lunar and Planetary Science Conference, Houston, TX VL - 22 KW - tomography KW - meteorites KW - X-ray data KW - data processing KW - composition KW - microtomography KW - 05B:Petrology of meteorites and tektites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50304832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Computed+microtomography+%28CMT%29+of+the+internal+structures+of+rare+extraterrestrial+objects&rft.au=Sutton%2C+S+R%3BSpanne%2C+P%3BRivers%2C+M+L%3BJones%2C+K+W&rft.aulast=Sutton&rft.aufirst=S&rft.date=1991-01-01&rft.volume=22&rft.issue=&rft.spage=1367&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-second lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 2 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - composition; data processing; meteorites; microtomography; tomography; X-ray data ER - TY - JOUR T1 - Chromium valency in individual lunar olivine grains using X-ray absorption near edge structure (XANES) microanalysis AN - 50303943; 1993-045441 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Sutton, S R AU - Jones, K W AU - Gordon, B AU - Rivers, M L AU - Smith, J V A2 - Ryder, Graham A2 - Sharpton, Virgil L. Y1 - 1991 PY - 1991 DA - 1991 SP - 1365 EP - 1366 PB - Lunar and Planetary Science Conference, Houston, TX VL - 22 KW - silicates KW - Moon KW - oxidation KW - olivine group KW - nesosilicates KW - lunar samples KW - X-ray data KW - speciation KW - metals KW - orthosilicates KW - valency KW - XANES data KW - geochemistry KW - chromium KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50303943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Chromium+valency+in+individual+lunar+olivine+grains+using+X-ray+absorption+near+edge+structure+%28XANES%29+microanalysis&rft.au=Sutton%2C+S+R%3BJones%2C+K+W%3BGordon%2C+B%3BRivers%2C+M+L%3BSmith%2C+J+V&rft.aulast=Sutton&rft.aufirst=S&rft.date=1991-01-01&rft.volume=22&rft.issue=&rft.spage=1365&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-second lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 6 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - chromium; geochemistry; lunar samples; metals; Moon; nesosilicates; olivine group; orthosilicates; oxidation; silicates; speciation; valency; X-ray data; XANES data ER - TY - JOUR T1 - Scanning transmission ion microscopy (STIM); a new technique for density mapping of micrometeorites AN - 50206623; 1995-000667 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Sutton, S R AU - Cholewa, M AU - Bench, G AU - Saint, A AU - Legge, G J F AU - Weirup, D AU - Flynn, G J AU - Anonymous Y1 - 1991 PY - 1991 DA - 1991 SP - 1363 EP - 1364 PB - Lunar and Planetary Science Conference, Houston, TX VL - 22 KW - micrometeorites KW - meteorites KW - density KW - scanning transmission ion microscopy data KW - interplanetary dust KW - 05B:Petrology of meteorites and tektites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50206623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Scanning+transmission+ion+microscopy+%28STIM%29%3B+a+new+technique+for+density+mapping+of+micrometeorites&rft.au=Sutton%2C+S+R%3BCholewa%2C+M%3BBench%2C+G%3BSaint%2C+A%3BLegge%2C+G+J+F%3BWeirup%2C+D%3BFlynn%2C+G+J%3BAnonymous&rft.aulast=Sutton&rft.aufirst=S&rft.date=1991-01-01&rft.volume=22&rft.issue=&rft.spage=1363&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-second lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - Number of references - 8 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - density; interplanetary dust; meteorites; micrometeorites; scanning transmission ion microscopy data ER - TY - JOUR T1 - Solid state conversion of pyroxene to olivine in the presence of a water-rich mafic magma AN - 50070465; 1996-016516 JF - Abstracts with Programs - Geological Society of America AU - Salpas, Peter A AU - Sutton, Stephen R AU - Anonymous Y1 - 1991 PY - 1991 DA - 1991 SP - 270 PB - Geological Society of America (GSA), Boulder, CO VL - 23 IS - 5 SN - 0016-7592, 0016-7592 KW - United States KW - silicates KW - igneous rocks KW - mafic composition KW - olivine group KW - recrystallization KW - pyroxene group KW - plutonic rocks KW - mineral composition KW - olivine KW - orthosilicates KW - spectra KW - Stillwater Complex KW - norite KW - mafic magmas KW - chain silicates KW - Precambrian KW - Pillow Troctolite KW - X-ray spectra KW - Montana KW - solid phase KW - nesosilicates KW - magmas KW - infiltration KW - gabbros KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50070465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Solid+state+conversion+of+pyroxene+to+olivine+in+the+presence+of+a+water-rich+mafic+magma&rft.au=Salpas%2C+Peter+A%3BSutton%2C+Stephen+R%3BAnonymous&rft.aulast=Salpas&rft.aufirst=Peter&rft.date=1991-01-01&rft.volume=23&rft.issue=5&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1991 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - chain silicates; gabbros; igneous rocks; infiltration; mafic composition; mafic magmas; magmas; mineral composition; Montana; nesosilicates; norite; olivine; olivine group; orthosilicates; Pillow Troctolite; plutonic rocks; Precambrian; pyroxene group; recrystallization; silicates; solid phase; spectra; Stillwater Complex; United States; X-ray spectra ER - TY - JOUR T1 - Multilayer sampling in the water-table region of a sandy aquifer AN - 13730489; 199102890 AB - A multi-layer sampler, developed to sample groundwater at various depths under natural flow conditions, was used to study the water-table region of a contaminated site at Brookhaven National Laboratory, located above the sole-source aquifer of Long Island, N.Y. Depth profiles of organic pollutants, metals and anions were obtained. The sampler was capable of yielding vertical profiles with a resolution of a few centimetres. In a vertical interval of 200 cm from the water table, concentrations of all solutes investigated except sulphate showed microscale heterogeneities. In the case of chloride, manganese and iron, a long linear gradient of concentration versus depth was observed, probably attributable to vertical mixing due to rainwater input. There are 35 references. JF - Ground Water AU - Kaplan, E AU - Banerjee, S AU - Ronen, D AU - Magaritz, M AU - Machlin, A AU - Sosnow, M AU - Koglin, E AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1991 PY - 1991 DA - 1991 SP - 191 EP - 198 VL - 29 IS - 2 SN - 0017-467X, 0017-467X KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13730489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ground+Water&rft.atitle=Multilayer+sampling+in+the+water-table+region+of+a+sandy+aquifer&rft.au=Kaplan%2C+E%3BBanerjee%2C+S%3BRonen%2C+D%3BMagaritz%2C+M%3BMachlin%2C+A%3BSosnow%2C+M%3BKoglin%2C+E&rft.aulast=Kaplan&rft.aufirst=E&rft.date=1991-01-01&rft.volume=29&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Ground+Water&rft.issn=0017467X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Effect of iron limitation on photosynthesis in a marine diatom AN - 13694542; S199445753 AB - The response of the marine diatom Phaeodactylum tricornutum to iron deficiency was evaluated in the context of fundamental physiological models of growth and photosynthesis. Iron deficiency induced chlorosis, which decreased Chlorophyll-a:carbon ratios and Chlorophyll-a-specific light-saturated photosynthesis (PmB). Iron-deficient cells, growing at less than 20 per cent of their maximal growth rate, had reduced cellular carbon, nitrogen and phosphorus contents, but maintained carbon:nitrogen:phosphorus ratios at the Redfield proportions. These results imply that carbon:nitrogen:phosphorus ratios do not provide an unequivocal index of relative growth rate. There are 54 references. JF - Limnology and Oceanography AU - Greene, R M AU - Geider, R J AU - Falkowski, P G AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1991 PY - 1991 DA - 1991 SP - 1772 EP - 1782 VL - 36 IS - 8 SN - 0024-3590, 0024-3590 KW - Light KW - Modelling (-general-) KW - Reduction KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13694542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Effect+of+iron+limitation+on+photosynthesis+in+a+marine+diatom&rft.au=Greene%2C+R+M%3BGeider%2C+R+J%3BFalkowski%2C+P+G&rft.aulast=Greene&rft.aufirst=R&rft.date=1991-01-01&rft.volume=36&rft.issue=8&rft.spage=1772&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Comparison of measured parameters from a 24-keV and a broad spectrum epithermal neutron beam for neutron capture therapy: an identification of consequential parameters. AN - 80239072; 2280734 AB - Epithermal neutron beams are under development in a number of locations in the U.S. and abroad. The increased penetration in tissue provided by these neurons should circumvent problems associated with the rapid attenuation of thermal neutron beams encountered in previous clinical trials of neutron capture therapy (NCT). Physical and radiobiological experiments with two "intermediate energy" or "epithermal" beams have been reported. A comparison is made here between the 24-keV iron-filtered beam at Harwell, England, and the broad-spectrum Al2 O3 moderated beam at the Brookhaven Medical Research Reactor (BMRR). In addition, parameters which are relevant for NCT, and which are best suited for evaluation and comparison of beams, are discussed. Particular attention is paid to the mean neutron energy which can be tolerated without significant reduction of therapeutic gain (TG), where TG is the ratio of tumor dose to maximum normal tissue dose. It is suggested that the simplest and most meaningful parameters for comparison of beam intensity and purity are the epithermal neutron fluence rate, and the fast neutron dose per epithermal neutron (4.2 X 10(-11) rad/neutron for the broad-spectrum beam and 29 X 10(-11) rad/neutron for the 24-keV beam). While the Al2O3 beam is close to optimal, the 24-keV beam produces a significant fast neutron dose which results in a lower TG.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Medical physics AU - Fairchild, R G AU - Saraf, S K AU - Kalef-Ezra, J AU - Laster, B H AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. PY - 1990 SP - 1045 EP - 1052 VL - 17 IS - 6 SN - 0094-2405, 0094-2405 KW - Index Medicus KW - Evaluation Studies as Topic KW - Relative Biological Effectiveness KW - Radiotherapy Dosage KW - Humans KW - Brain Neoplasms -- radiotherapy KW - Fast Neutrons -- therapeutic use KW - Biophysical Phenomena KW - Biophysics KW - Neutrons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80239072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+physics&rft.atitle=Comparison+of+measured+parameters+from+a+24-keV+and+a+broad+spectrum+epithermal+neutron+beam+for+neutron+capture+therapy%3A+an+identification+of+consequential+parameters.&rft.au=Fairchild%2C+R+G%3BSaraf%2C+S+K%3BKalef-Ezra%2C+J%3BLaster%2C+B+H&rft.aulast=Fairchild&rft.aufirst=R&rft.date=1990-11-01&rft.volume=17&rft.issue=6&rft.spage=1045&rft.isbn=&rft.btitle=&rft.title=Medical+physics&rft.issn=00942405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-03-08 N1 - Date created - 1991-03-08 N1 - Date revised - 2017-02-18 N1 - Last updated - 2017-02-23 ER - TY - JOUR T1 - Lead impairs the production of osteocalcin by rat osteosarcoma (ROS 17/2.8) cells. AN - 80169038; 2256116 AB - The serum level of osteocalcin, a bone-specific protein produced by osteoblasts and an index of bone formation, is decreased in lead-intoxicated children. To elucidate the effect of lead on the hormonal regulation of osteocalcin production, ROS 17/2.8 cells were treated with 0, 5, 10, or 25 microM lead acetate for 24 hr, followed by an additional 24-hr lead treatment with or without 100 pg 1,25-dihydroxyvitamin D3/ml medium. At the end of this period a radioimmunoassay was conducted to determine the amount of osteocalcin present in the cells and secreted into the medium. 1,25-Dihydroxyvitamin D3 increased osteocalcin secretion in control cultures, but this increase was prevented by lead in a concentration-dependent manner. Osteocalcin secretion by cultures treated with 10 or 25 microM lead was even lower than in cultures not stimulated with 1,25-dihydroxyvitamin D3. Intracellular levels of osteocalcin were slightly elevated with 1,25-dihydroxyvitamin D3, and there was no lead effect on cellular levels. These data indicate that lead attenuates basal and 1,25-dihydroxyvitamin D3-stimulated production of osteocalcin in ROS 17/2.8 cells. Because osteocalcin appears to play a central role in bone mineralization, altered osteocalcin production may be a key event in the skeletal toxicity of lead. JF - Toxicology and applied pharmacology AU - Long, G J AU - Rosen, J F AU - Pounds, J G AD - Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1990/11// PY - 1990 DA - November 1990 SP - 270 EP - 277 VL - 106 IS - 2 SN - 0041-008X, 0041-008X KW - Osteocalcin KW - 104982-03-8 KW - Lead KW - 2P299V784P KW - Calcitriol KW - FXC9231JVH KW - Index Medicus KW - Rats KW - Animals KW - Tumor Cells, Cultured KW - Dose-Response Relationship, Drug KW - Time Factors KW - Radioimmunoassay KW - Lead Poisoning -- metabolism KW - Calcitriol -- pharmacology KW - Lead -- toxicity KW - Osteosarcoma -- pathology KW - Osteosarcoma -- metabolism KW - Lead -- administration & dosage KW - Osteocalcin -- secretion KW - Osteocalcin -- biosynthesis KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80169038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Lead+impairs+the+production+of+osteocalcin+by+rat+osteosarcoma+%28ROS+17%2F2.8%29+cells.&rft.au=Long%2C+G+J%3BRosen%2C+J+F%3BPounds%2C+J+G&rft.aulast=Long&rft.aufirst=G&rft.date=1990-11-01&rft.volume=106&rft.issue=2&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-01-23 N1 - Date created - 1991-01-23 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - In vivo toxicity of 3'-azido-3'-deoxythymidine (AZT) on CBA/Ca mice. AN - 80088771; 2230284 AB - CBA/Ca male mice were given 3'-azido-3'-deoxythymidine (AZT) in drinking water (1 mg/ml) for up to 7 weeks. Water consumption and body weight decreased significantly. Neutropenia and lymphopenia were observed during and after exposure. Significant macrocytic anemia developed and disappeared as a function of red cell life span after stopping AZT intake. A microthrombocytosis was seen. Bone marrow cellularity and spleen colony-forming unit (CFU-s) content fell, but recovered completely and quickly after terminating AZT intake. Hemopoietic stem cell function measured by 2 different methods of rescuing fatally irradiated mice was normal 4 weeks after AZT exposure, suggesting that AZT treatment does not induce a long-lasting effect in genetic control of mitotic potential of stem cells. This is in marked contrast to exposure of CBA/Ca mice to benzene and ionizing radiation. JF - International journal of cell cloning AU - Cronkite, E P AU - Bullis, J AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1990/09// PY - 1990 DA - September 1990 SP - 332 EP - 345 VL - 8 IS - 5 SN - 0737-1454, 0737-1454 KW - Water KW - 059QF0KO0R KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - AIDS/HIV KW - Administration, Oral KW - Animals KW - Random Allocation KW - Mice KW - Hematopoietic Stem Cells -- drug effects KW - Mice, Inbred CBA KW - Cell Count -- drug effects KW - Body Weight -- drug effects KW - Mitosis -- drug effects KW - Leukemia, Experimental -- chemically induced KW - Time Factors KW - Bone Marrow -- drug effects KW - Hematopoietic Stem Cells -- radiation effects KW - Male KW - Organ Size -- drug effects KW - Zidovudine -- toxicity KW - Zidovudine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80088771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cell+cloning&rft.atitle=In+vivo+toxicity+of+3%27-azido-3%27-deoxythymidine+%28AZT%29+on+CBA%2FCa+mice.&rft.au=Cronkite%2C+E+P%3BBullis%2C+J&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1990-09-01&rft.volume=8&rft.issue=5&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cell+cloning&rft.issn=07371454&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-12-05 N1 - Date created - 1990-12-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - In vitro determination of uptake, retention, distribution, biological efficacy, and toxicity of boronated compounds for neutron capture therapy: a comparison of porphyrins with sulfhydryl boron hydrides. AN - 79911112; 2379150 AB - A major problem remaining in the evaluation of boronated compounds for neutron capture therapy (NCT) is the need to know the intra- or extracellular microdistribution of boron. This is a consequence of the short range of the 10B(n,alpha)7Li reaction products (approximately 10 microns), such that biological efficacy is dependent upon intracellular distribution. In particular, if boron location is predominantly extracellular, a significant reduction in efficacy would be expected. The in vitro procedure described here was developed mainly to provide information regarding the intra- and extracellular location and concentration of boron. However, use of the technique also allows the measurement of compound uptake and retention (binding) and the determination of biological efficacy by the evaluation of survival curves obtained following irradiation with thermal neutrons. Comparison is made to results obtained with boric acid (H3(10)BO3) and to results calculated for various boron distributions. Concomitantly, an indication of compound toxicity can be obtained from the plating efficiency of unirradiated control cells. Currently, most investigators utilize in vivo systems for testing and evaluating boron uptake from various carrier molecules. Given the large number of boron compounds being synthesized and needing evaluation as to their usefulness for NCT, the in vitro technique described here is simple and advantageous for initial compound screening. In addition to sparing animal lives, it is both time and cost effective and utilizes much smaller quantities of test compound than are required for an in vivo assay. A boronated porphyrin (BOPP) evaluated by the above procedure shows an uptake and retention approximately 20 times that of sulfhydryl boron hydride monomer (BSH); the latter compound is currently being used clinically for NCT in Japan and is anticipated for use in clinical trials in the United States. If the advantages demonstrated by BOPP in these in vitro studies are validated in animal experiments, BOPP should be considered for clinical application. JF - Cancer research AU - Fairchild, R G AU - Kahl, S B AU - Laster, B H AU - Kalef-Ezra, J AU - Popenoe, E A AD - Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1990/08/15/ PY - 1990 DA - 1990 Aug 15 SP - 4860 EP - 4865 VL - 50 IS - 16 SN - 0008-5472, 0008-5472 KW - Boranes KW - 0 KW - Borohydrides KW - Isotopes KW - Sulfhydryl Compounds KW - Sulfides KW - mercaptoundecahydrododecaborate KW - 12294-22-3 KW - sulfhydryl borane dimer KW - 62962-06-5 KW - Boron KW - N9E3X5056Q KW - Index Medicus KW - Animals KW - Kinetics KW - Dose-Response Relationship, Radiation KW - Cell Line KW - Boranes -- pharmacology KW - Sulfides -- chemical synthesis KW - Sulfhydryl Compounds -- pharmacology KW - Cell Division -- drug effects KW - Neutrons KW - Cell Survival -- drug effects KW - Boron -- therapeutic use KW - Radiotherapy -- methods KW - Cell Survival -- radiation effects KW - Sulfides -- pharmacology KW - Boranes -- chemical synthesis KW - Cell Division -- radiation effects KW - Sulfhydryl Compounds -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79911112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=In+vitro+determination+of+uptake%2C+retention%2C+distribution%2C+biological+efficacy%2C+and+toxicity+of+boronated+compounds+for+neutron+capture+therapy%3A+a+comparison+of+porphyrins+with+sulfhydryl+boron+hydrides.&rft.au=Fairchild%2C+R+G%3BKahl%2C+S+B%3BLaster%2C+B+H%3BKalef-Ezra%2C+J%3BPopenoe%2C+E+A&rft.aulast=Fairchild&rft.aufirst=R&rft.date=1990-08-15&rft.volume=50&rft.issue=16&rft.spage=4860&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-12 N1 - Date created - 1990-09-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Genetic and structural characterization of endA. A membrane-bound nuclease required for transformation of Streptococcus pneumoniae. AN - 79846515; 2359120 AB - The endA gene encoding the membrane nuclease of Streptococcus pneumoniae, which is necessary for DNA uptake in genetic transformation, was cloned in a streptococcal vector. This was accomplished by insertional mutagenesis of the gene, cloning of the mutant allele, and substitution of the wild-type allele by chromosomal facilitation of plasmid establishment. Plasmids carrying the endA+ gene complemented cells with endA- in the chromosome to restore DNAase activity and transformability. Determination of its DNA sequence showed the gene to encode a 30 kDa protein, EndA, with a typical signal sequence for membrane transport at its amino end. In vitro synthesis of EndA showed the initial translation product to be enzymatically active without further processing. Comparison with EndA found in cell membranes indicated that the enzyme retained its signal sequence, which apparently anchored the otherwise hydrophilic protein to the membrane. From the nucleotide sequence in the vicinity of endA and the effect of various insertions and deletions, it appears that endA is the last gene in an operon containing at least two other genes. Neither of these upstream genes, nor the downstream gene, are essential for either cell viability or transformability. JF - Journal of molecular biology AU - Puyet, A AU - Greenberg, B AU - Lacks, S A AD - Department of Biology, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1990/06/20/ PY - 1990 DA - 1990 Jun 20 SP - 727 EP - 738 VL - 213 IS - 4 SN - 0022-2836, 0022-2836 KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - Membrane Proteins KW - Deoxyribonucleases KW - EC 3.1.- KW - Endodeoxyribonucleases KW - endA protein, bacteria KW - EC 3.1.30.- KW - Index Medicus KW - Genetic Linkage KW - Genes, Bacterial KW - Base Sequence KW - Cell Membrane -- enzymology KW - Sequence Homology, Nucleic Acid KW - DNA, Bacterial -- genetics KW - Restriction Mapping KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Plasmids KW - Mutation KW - Cloning, Molecular KW - Transformation, Bacterial KW - Streptococcus pneumoniae -- enzymology KW - Deoxyribonucleases -- genetics KW - Endodeoxyribonucleases -- genetics KW - Streptococcus pneumoniae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79846515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Genetic+and+structural+characterization+of+endA.+A+membrane-bound+nuclease+required+for+transformation+of+Streptococcus+pneumoniae.&rft.au=Puyet%2C+A%3BGreenberg%2C+B%3BLacks%2C+S+A&rft.aulast=Puyet&rft.aufirst=A&rft.date=1990-06-20&rft.volume=213&rft.issue=4&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-01 N1 - Date created - 1990-08-01 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Effects of chronic cocaine abuse on postsynaptic dopamine receptors. AN - 79789312; 2343913 AB - To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [18F]N-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. Cocaine abusers who had been detoxified for 1 week or less showed significantly lower values for uptake of [18F]N-methylspiroperidol in striatum than the normal subjects, whereas the cocaine abusers who had been detoxified for 1 month showed values comparable to those obtained from normal subjects. The authors conclude that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval. JF - The American journal of psychiatry AU - Volkow, N D AU - Fowler, J S AU - Wolf, A P AU - Schlyer, D AU - Shiue, C Y AU - Alpert, R AU - Dewey, S L AU - Logan, J AU - Bendriem, B AU - Christman, D AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000. Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 719 EP - 724 VL - 147 IS - 6 SN - 0002-953X, 0002-953X KW - Fluorine Radioisotopes KW - 0 KW - Receptors, Dopamine KW - Spiperone KW - 4X6E73CJ0Q KW - 3-N-methylspiperone KW - 87539-19-3 KW - Cocaine KW - I5Y540LHVR KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Corpus Striatum -- metabolism KW - Up-Regulation -- drug effects KW - Adult KW - Spiperone -- metabolism KW - Tomography, Emission-Computed KW - Fluorine Radioisotopes -- metabolism KW - Spiperone -- analogs & derivatives KW - Down-Regulation -- drug effects KW - Basal Ganglia -- metabolism KW - Receptors, Dopamine -- drug effects KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- rehabilitation KW - Cocaine -- pharmacology KW - Receptors, Dopamine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79789312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Effects+of+chronic+cocaine+abuse+on+postsynaptic+dopamine+receptors.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWolf%2C+A+P%3BSchlyer%2C+D%3BShiue%2C+C+Y%3BAlpert%2C+R%3BDewey%2C+S+L%3BLogan%2C+J%3BBendriem%2C+B%3BChristman%2C+D&rft.aulast=Volkow&rft.aufirst=N&rft.date=1990-06-01&rft.volume=147&rft.issue=6&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-25 N1 - Date created - 1990-06-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - The Elephant Moraine mare basalt breccia and the importance of the lunar meteorites as samples of the lunar crust AN - 52804791; 1996-071453 JF - Papers Presented to the ... Symposium on Antarctic Meteorites AU - Delaney, Jeremy S AU - Sutton, S R AU - Hervig, R L AU - Anonymous Y1 - 1990/06// PY - 1990 DA - June 1990 SP - 116 EP - 118 PB - National Institute of Polar Research, Tokyo VL - 15 KW - lunar meteorites KW - breccia KW - volcanic rocks KW - stony meteorites KW - impactites KW - Moon KW - textures KW - igneous rocks KW - EET 87521 KW - lunar breccia KW - Elephant Moraine Meteorites KW - impact breccia KW - lunar highlands KW - maria KW - achondrites KW - meteorites KW - Antarctica KW - metamorphic rocks KW - lunar crust KW - basalts KW - petrography KW - 05B:Petrology of meteorites and tektites KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52804791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Papers+Presented+to+the+...+Symposium+on+Antarctic+Meteorites&rft.atitle=The+Elephant+Moraine+mare+basalt+breccia+and+the+importance+of+the+lunar+meteorites+as+samples+of+the+lunar+crust&rft.au=Delaney%2C+Jeremy+S%3BSutton%2C+S+R%3BHervig%2C+R+L%3BAnonymous&rft.aulast=Delaney&rft.aufirst=Jeremy&rft.date=1990-06-01&rft.volume=15&rft.issue=&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Papers+Presented+to+the+...+Symposium+on+Antarctic+Meteorites&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Fifteenth symposium on Antarctic meteorites N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 11 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #03644 N1 - SubjectsTermNotLitGenreText - achondrites; Antarctica; basalts; breccia; EET 87521; Elephant Moraine Meteorites; igneous rocks; impact breccia; impactites; lunar breccia; lunar crust; lunar highlands; lunar meteorites; maria; metamorphic rocks; meteorites; Moon; petrography; stony meteorites; textures; volcanic rocks ER - TY - JOUR T1 - Inactivation of human and simian rotaviruses by chlorine dioxide. AN - 79776576; 2160222 AB - The inactivation of single-particle stocks of human (type 2, Wa) and simian (SA-11) rotaviruses by chlorine dioxide was investigated. Experiments were conducted at 4 degrees C in a standard phosphate-carbonate buffer. Both virus types were rapidly inactivated, within 20 s under alkaline conditions, when chlorine dioxide concentrations ranging from 0.05 to 0.2 mg/liter were used. Similar reductions of 10(5)-fold in infectivity required additional exposure time of 120 s at 0.2 mg/liter for Wa and at 0.5 mg/liter for SA-11, respectively, at pH 6.0. The inactivation of both virus types was moderate at neutral pH, and the sensitivities to chlorine dioxide were similar. The observed enhancement of virucidal efficiency with increasing pH was contrary to earlier findings with chlorine- and ozone-treated rotavirus particles, where efficiencies decreased with increasing alkalinity. Comparison of 99.9% virus inactivation times revealed ozone to be the most effective virucidal agent among these three disinfectants. JF - Applied and environmental microbiology AU - Chen, Y S AU - Vaughn, J M AD - Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1990/05// PY - 1990 DA - May 1990 SP - 1363 EP - 1366 VL - 56 IS - 5 SN - 0099-2240, 0099-2240 KW - Chlorine Compounds KW - 0 KW - Disinfectants KW - Oxides KW - Chlorine KW - 4R7X1O2820 KW - chlorine dioxide KW - 8061YMS4RM KW - Index Medicus KW - Animals KW - Hydrogen-Ion Concentration KW - Humans KW - Haplorhini KW - Rotavirus -- drug effects KW - Oxides -- pharmacology KW - Chlorine -- pharmacology KW - Disinfectants -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79776576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Inactivation+of+human+and+simian+rotaviruses+by+chlorine+dioxide.&rft.au=Chen%2C+Y+S%3BVaughn%2C+J+M&rft.aulast=Chen&rft.aufirst=Y&rft.date=1990-05-01&rft.volume=56&rft.issue=5&rft.spage=1363&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-06-21 N1 - Date created - 1990-06-21 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Appl Microbiol. 1965 Sep;13(5):776-80 [5325940] Appl Environ Microbiol. 1987 Sep;53(9):2218-21 [2823709] Lancet. 1976 Jan 10;1(7950):96 [54622] N Engl J Med. 1977 Jun 2;296(22):1298-9 [193006] Lancet. 1976 Aug 21;2(7982):423 [73889] Intervirology. 1979;11(3):133-5 [429146] Scand J Infect Dis. 1980;12(3):161-4 [6254138] Am J Epidemiol. 1981 Jun;113(6):703-10 [6263087] N Engl J Med. 1982 Apr 29;306(17):1010-2 [7038501] Appl Environ Microbiol. 1982 Nov;44(5):1064-71 [6295277] J Infect. 1980 Mar;2(1):33-7 [7185915] Curr Top Microbiol Immunol. 1983;105:123-84 [6313296] Lancet. 1984 May 26;1(8387):1139-42 [6144874] J Hyg (Lond). 1984 Aug;93(1):157-63 [6086748] Appl Environ Microbiol. 1984 Aug;48(2):317-23 [6091546] Appl Environ Microbiol. 1986 Feb;51(2):391-4 [3006589] Lancet. 1975 Aug 9;2(7928):241-3 [49794] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Acute effects of ethanol on regional brain glucose metabolism and transport. AN - 79866837; 2164230 AB - To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain. JF - Psychiatry research AU - Volkow, N D AU - Hitzemann, R AU - Wolf, A P AU - Logan, J AU - Fowler, J S AU - Christman, D AU - Dewey, S L AU - Schlyer, D AU - Burr, G AU - Vitkun, S AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1990/04// PY - 1990 DA - April 1990 SP - 39 EP - 48 VL - 35 IS - 1 SN - 0165-1781, 0165-1781 KW - Blood Glucose KW - 0 KW - Receptors, GABA-A KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Deoxyglucose KW - 9G2MP84A8W KW - Index Medicus KW - Alcoholic Intoxication -- diagnostic imaging KW - Brain Mapping KW - Receptors, GABA-A -- physiology KW - Humans KW - Energy Metabolism -- physiology KW - Adult KW - Deoxyglucose -- analogs & derivatives KW - Male KW - Deoxyglucose -- metabolism KW - Blood Glucose -- metabolism KW - Alcoholism -- diagnostic imaging KW - Tomography, Emission-Computed KW - Alcohol Drinking -- physiology KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79866837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Acute+effects+of+ethanol+on+regional+brain+glucose+metabolism+and+transport.&rft.au=Volkow%2C+N+D%3BHitzemann%2C+R%3BWolf%2C+A+P%3BLogan%2C+J%3BFowler%2C+J+S%3BChristman%2C+D%3BDewey%2C+S+L%3BSchlyer%2C+D%3BBurr%2C+G%3BVitkun%2C+S&rft.aulast=Volkow&rft.aufirst=N&rft.date=1990-04-01&rft.volume=35&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-08-16 N1 - Date created - 1990-08-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - The role of cell calcium in current approaches to toxicology. AN - 79816170; 2190820 AB - All cells contain elaborate systems for the spatial and temporal regulation of the calcium ion, [Ca2+]i, and diverse Ca2+ receptor and biochemical response systems that are regulated by these changes in [Ca2+]i. Toxicants that perturb the mobilization or homeostasis of [Ca2+]i will place the regulation of these processes outside the normal range of physiological control. Many classes of chemical toxicants, including metals, solvents, and pesticides, may have particular aspects of cell calcium as key cellular and molecular targets of toxicant action. However, experimental proof of these targets as a specific site of toxicant action is challenging and technically difficult as a result of the complexity and diversity of these processes. To fully establish and understand the target role of the calcium messenger system in toxicant action, it is necessary to distinguish between the effects of a toxicant on (a) the calcium mobilization and homeostatic processes, (b) the calcium-mediated processes, and (c) from those processes which co-regulate or counter-regulate these calcium-mediated processes. As our understanding of the calcium messenger system expands, these insights will be increasingly applied to understanding the mechanisms of action of toxic chemicals. JF - Environmental health perspectives AU - Pounds, J G AD - Department of Applied Science, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1990/03// PY - 1990 DA - March 1990 SP - 7 EP - 15 VL - 84 SN - 0091-6765, 0091-6765 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Humans KW - Research Design KW - Calcium -- physiology KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79816170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+role+of+cell+calcium+in+current+approaches+to+toxicology.&rft.au=Pounds%2C+J+G&rft.aulast=Pounds&rft.aufirst=J&rft.date=1990-03-01&rft.volume=84&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-07-16 N1 - Date created - 1990-07-16 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: J Biol Chem. 1976 Feb 25;251(4):1197-201 [1249072] Toxicol Appl Pharmacol. 1988 Feb;92(2):157-69 [2963406] FEBS Lett. 1980 Jul 28;116(2):141-4 [7409141] Toxicol Appl Pharmacol. 1982 May;63(3):402-8 [6179262] Science. 1983 Apr 15;220(4594):308-10 [6301003] Biochem Pharmacol. 1983 Mar 15;32(6):963-9 [6301510] Life Sci. 1983 Aug 1;33(5):401-8 [6348456] C R Seances Acad Sci III. 1983;296(17):811-4 [6193848] Biochem Soc Trans. 1984 Feb;12(1):23-8 [6705980] Nature. 1984 Apr 19-25;308(5961):693-8 [6232463] Nature. 1984 Sep 13-19;311(5982):127-31 [6088995] FEBS Lett. 1984 Oct 15;176(1):151-4 [6208053] Environ Health Perspect. 1984 Aug;57:321-3 [6499814] Fed Proc. 1984 Dec;43(15):2995-9 [6389184] Fed Proc. 1984 Dec;43(15):3000-4 [6500074] Fed Proc. 1984 Dec;43(15):3011-4 [6149959] Neurotoxicology. 1984 Fall;5(3):295-331 [6151637] J Biol Chem. 1985 Jun 10;260(11):6816-9 [3997849] Annu Rev Biochem. 1985;54:205-35 [2992357] Crit Rev Toxicol. 1985;16(2):157-83 [3910355] J Biol Chem. 1986 Mar 5;261(7):3006-12 [3949758] N Engl J Med. 1986 Apr 24;314(17):1094-101 [2870434] N Engl J Med. 1986 May 1;314(18):1164-70 [3007987] Biochem Pharmacol. 1986 Apr 15;35(8):1331-5 [3964302] N Engl J Med. 1986 Jun 26;314(26):1670-6 [3520320] J Pharmacol Exp Ther. 1986 Jul;238(1):186-91 [3014115] J Pharmacol Exp Ther. 1986 Aug;238(2):618-24 [3735133] J Cell Physiol. 1986 Dec;129(3):356-66 [3782310] J Neurochem. 1987 Feb;48(2):383-9 [2432178] Science. 1987 Jan 2;235(4784):46-52 [2432656] Am J Physiol. 1987 Jan;252(1 Pt 2):F1-10 [3544865] Cell Calcium. 1986 Dec;7(5-6):297-307 [2949845] Cell Calcium. 1986 Dec;7(5-6):339-52 [3545486] Immunol Rev. 1987 Feb;95:59-87 [2437015] Prog Neurobiol. 1987;29(4):321-64 [3303136] Br Med Bull. 1986 Oct;42(4):353-8 [3307995] Br Med Bull. 1986 Oct;42(4):385-90 [3307997] Br Med Bull. 1986 Oct;42(4):431-4 [3308000] J Biol Chem. 1987 Dec 5;262(34):16333-7 [2445745] Am J Physiol. 1987 Dec;253(6 Pt 2):H1601-11 [2447792] Endocrinol Metab Clin North Am. 1987 Dec;16(4):919-45 [2828041] Science. 1988 Feb 26;239(4843):998-1005 [2830669] Hematol Oncol Clin North Am. 1988 Mar;2(1):101-34 [2831184] Am J Nephrol. 1987;7 Suppl 1:24-31 [2831717] Toxicol Appl Pharmacol. 1988 Mar 30;93(1):101-7 [2832972] Annu Rev Med. 1988;39:531-44 [3285790] Hypertension. 1988 Jun;11(6 Pt 2):724-38 [3292417] Toxicol Appl Pharmacol. 1988 Jul;94(3):331-41 [3041648] Trends Biochem Sci. 1988 Mar;13(3):75-6 [3245065] Biochem Pharmacol. 1980 Jun 15;29(12):1815-23 [6105872] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Cellular lead toxicity and metabolism in primary and clonal osteoblastic bone cells. AN - 79605315; 2105542 AB - A knowledge of bone lead metabolism is critical for understanding the toxicological importance of bone lead, as a toxicant both to bone cells and to soft tissues of the body, as lead is mobilized from large reservoirs in hard tissues. To further understand the processes that mediate metabolism of lead in bone, it is necessary to determine lead metabolism at the cellular level. Experiments were conducted to determine the intracellular steady-state 210Pb kinetics in cultures of primary and clonal osteoblastic bone cells. Osteoblastic bone cells obtained by sequential collagenase digestion of mouse calvaria or rat osteosarcoma (ROS 17/2.8) cells were labeled with 210Pb as 5 microM lead acetate for 20 hr, and kinetic parameters were determined by measuring the efflux of 210Pb from the cells over a 210-min period. The intracellular metabolism of 210Pb was characterized by three kinetic pools of 210Pb in both cell types. Although the values of these parameters differed between the primary osteoblastic cells and ROS cells, the profile of 210Pb was remarkably similar in both cell types. Both types exhibited one large, slowly exchanging pool (S3), indicative of mitochondrial lead. These data show that primary osteoblastic bone cells and ROS cells exhibit similar steady-state lead kinetics, and intracellular lead distribution. These data also establish a working model of lead kinetics in osteoblastic bone cells and now permit an integrated view of lead kinetics in bone. JF - Toxicology and applied pharmacology AU - Long, G J AU - Rosen, J F AU - Pounds, J G AD - Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1990/02// PY - 1990 DA - February 1990 SP - 346 EP - 361 VL - 102 IS - 2 SN - 0041-008X, 0041-008X KW - Lead Radioisotopes KW - 0 KW - Phosphates KW - Lead KW - 2P299V784P KW - Egtazic Acid KW - 526U7A2651 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Clone Cells KW - Animals KW - Osteosarcoma KW - Mice KW - Rats KW - Tumor Cells, Cultured KW - Cell Survival -- drug effects KW - Kinetics KW - Phosphates -- pharmacology KW - Mitochondria -- metabolism KW - Egtazic Acid -- pharmacology KW - L-Lactate Dehydrogenase -- metabolism KW - Osteoblasts -- metabolism KW - Osteoblasts -- drug effects KW - Osteoblasts -- ultrastructure KW - Lead -- toxicity KW - Lead -- pharmacology KW - Lead -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79605315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Cellular+lead+toxicity+and+metabolism+in+primary+and+clonal+osteoblastic+bone+cells.&rft.au=Long%2C+G+J%3BRosen%2C+J+F%3BPounds%2C+J+G&rft.aulast=Long&rft.aufirst=G&rft.date=1990-02-01&rft.volume=102&rft.issue=2&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-03-08 N1 - Date created - 1990-03-08 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Metabolic studies of drugs of abuse. AN - 80382619; 1876084 AB - Although still very preliminary, these studies exemplify how metabolic brain measurements can address questions of relevance in the investigation of drugs of addiction such as: 1. Mechanisms of drug toxicity, i.e., vascular pathology demonstrated from chronic use of cocaine. 2. Neurotransmitters that may be involved in the pharmacological actions of drugs, i.e., alcohol and the benzodiazepine-Gaba receptor complex, marijuana, and the cannabinoid receptor. 3. Mechanisms of drug withdrawal, i.e., hyperresponsivity of the brain to alcohol in the alcoholic, possibly as a consequence of increased sensitivity of the benzodiazepine-Gaba receptor complex. 4. Knowledge about brain function, i.e., the relation between activation of the cerebellum by marijuana and alcohol and the mood-changing effects of these drugs, suggests that the cerebellum may play a role in the mood disturbing actions seen with these drugs (a role which is different from the classical one which associates the cerebellum to motor regulation). Future work will provide more definitive answers to the above questions and will similarly provide information about mechanisms of toxicity, addiction, withdrawal, and reinforcement of other drugs of abuse. JF - NIDA research monograph AU - Volkow, N D AU - Fowler, J S AU - Wolf, A P AU - Gillespi, H AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1990 PY - 1990 DA - 1990 SP - 47 EP - 53 VL - 105 SN - 1046-9516, 1046-9516 KW - Street Drugs KW - 0 KW - Ethanol KW - 3K9958V90M KW - Cocaine KW - I5Y540LHVR KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Humans KW - Glucose -- metabolism KW - Tomography, Emission-Computed KW - Cannabis -- metabolism KW - Ethanol -- metabolism KW - Cocaine -- metabolism KW - Brain Chemistry -- drug effects KW - Substance-Related Disorders -- metabolism KW - Street Drugs -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80382619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Metabolic+studies+of+drugs+of+abuse.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWolf%2C+A+P%3BGillespi%2C+H&rft.aulast=Volkow&rft.aufirst=N&rft.date=1990-01-01&rft.volume=105&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-09-20 N1 - Date created - 1991-09-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Performance of the delayed- and prompt-gamma neutron activation systems at Brookhaven National Laboratory. AN - 80323272; 2088285 JF - Basic life sciences AU - Dilmanian, F A AU - Weber, D A AU - Yasumura, S AU - Kamen, Y AU - Lidofsky, L AU - Heymsfield, S B AU - Pierson, R N AU - Wang, J AU - Kehayias, J J AU - Ellis, K J AD - Medical Department, Brookhaven National Laboratory, Upton, N.Y. Y1 - 1990 PY - 1990 DA - 1990 SP - 309 EP - 315 VL - 55 SN - 0090-5542, 0090-5542 KW - Phosphorus KW - 27YLU75U4W KW - Chlorine KW - 4R7X1O2820 KW - Sodium KW - 9NEZ333N27 KW - Potassium KW - RWP5GA015D KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Chlorine -- analysis KW - Gamma Rays KW - Sodium -- analysis KW - Humans KW - Calcium -- analysis KW - Potassium -- analysis KW - Phosphorus -- analysis KW - Neutron Activation Analysis -- methods KW - Neutron Activation Analysis -- instrumentation KW - Body Composition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80323272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Performance+of+the+delayed-+and+prompt-gamma+neutron+activation+systems+at+Brookhaven+National+Laboratory.&rft.au=Dilmanian%2C+F+A%3BWeber%2C+D+A%3BYasumura%2C+S%3BKamen%2C+Y%3BLidofsky%2C+L%3BHeymsfield%2C+S+B%3BPierson%2C+R+N%3BWang%2C+J%3BKehayias%2C+J+J%3BEllis%2C+K+J&rft.aulast=Dilmanian&rft.aufirst=F&rft.date=1990-01-01&rft.volume=55&rft.issue=&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1991-05-17 N1 - Date created - 1991-05-17 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Is natural background or radiation from nuclear power plants leukemogenic? AN - 80003080; 2205872 AB - In view of the enormous number of base pair replications per annum in hemopoietic stem cells with the likelihood of coding errors, the rarity of the leukemogenic event at the cellular level after high doses of radiation, the infrequent occurrence of radiation events in cells at low-level exposure (large fraction of cells uninvolved), biological protective mechanisms and the realization that exposure of human populations to radiation from nuclear power plants is a very small fraction of natural radioactivity and will for the foreseeable future remain small and that populations exposed to high natural background radiation show no detectable harmful effects, it is concluded that either there is no effect, or for statistical reasons one cannot detect an effect. JF - Progress in clinical and biological research AU - Cronkite, E P AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1990 PY - 1990 DA - 1990 SP - 439 EP - 448 VL - 352 SN - 0361-7742, 0361-7742 KW - Index Medicus KW - Hematopoietic Stem Cells -- pathology KW - Humans KW - Child KW - Dose-Response Relationship, Radiation KW - Radiotherapy -- adverse effects KW - Japan -- epidemiology KW - Risk KW - Cell Transformation, Neoplastic -- radiation effects KW - Nuclear Warfare KW - Adult KW - Radiography -- adverse effects KW - United States -- epidemiology KW - Hematopoietic Stem Cells -- radiation effects KW - Military Medicine KW - Radiation, Ionizing KW - Power Plants KW - Leukemia, Radiation-Induced -- epidemiology KW - Background Radiation -- adverse effects KW - Leukemia, Radiation-Induced -- etiology KW - Nuclear Energy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80003080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+clinical+and+biological+research&rft.atitle=Is+natural+background+or+radiation+from+nuclear+power+plants+leukemogenic%3F&rft.au=Cronkite%2C+E+P&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1990-01-01&rft.volume=352&rft.issue=&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Progress+in+clinical+and+biological+research&rft.issn=03617742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-10-19 N1 - Date created - 1990-10-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Cyclosporine A inhibition of microcystin toxins. AN - 79957388; 2389255 AB - Cyclosporine A (CyA) given i.v. at a dose of 1.25 mg/mouse blocks a subsequent i.v. lethal dose (1.7-1.8 x LD50) of microcystin-LR for 24 hr, and is about 50% protective at 48 hr. Conversely, the fraction of mice that can be rescued by CyA (0.2 mg/mouse) after a lethal dose of microcystin-LR decreases rapidly with a pharmacodynamic half-time of only about 100 sec. The prophylactic action of CyA was tested against lethal doses of four microcystins. The acute lethality of 1.7-1.8 x LD50 dose of microcystin-LR, -RR, -LY, or -LA given 1 hr after administration of 0.2 mg of CyA is 0%, 0%, 58%, or 100%, respectively. Even a 0.6 mg/mouse dose of CyA is ineffective prophylaxis against a lethal dose of microcystin-LA. The inhibitory potency of CyA on microcystin toxicity can be completely reversed by the single L-amino acid substitution of alanine for arginine in the microcystin. JF - Toxicon : official journal of the International Society on Toxinology AU - Stoner, R D AU - Adams, W H AU - Slatkin, D N AU - Siegelman, H W AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1990 PY - 1990 DA - 1990 SP - 569 EP - 573 VL - 28 IS - 5 SN - 0041-0101, 0041-0101 KW - Cyclosporins KW - 0 KW - Microcystins KW - Peptides, Cyclic KW - cyanoginosin-LA KW - 96180-79-9 KW - microcystin RR KW - CZ021GH33H KW - cyanoginosin LR KW - EQ8332842Y KW - Index Medicus KW - Peptides, Cyclic -- antagonists & inhibitors KW - Mice, Inbred Strains KW - Animals KW - Death KW - Dose-Response Relationship, Drug KW - Mice KW - Time Factors KW - Male KW - Female KW - Cyclosporins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79957388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Cyclosporine+A+inhibition+of+microcystin+toxins.&rft.au=Stoner%2C+R+D%3BAdams%2C+W+H%3BSlatkin%2C+D+N%3BSiegelman%2C+H+W&rft.aulast=Stoner&rft.aufirst=R&rft.date=1990-01-01&rft.volume=28&rft.issue=5&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-09-27 N1 - Date created - 1990-09-27 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Selective delivery of boron by the melanin precursor analogue p-boronophenylalanine to tumors other than melanoma. AN - 79533025; 2293547 AB - The melanin precursor analogue p-boronophenylalanine (BPA) has been used to deliver 10B to melanoma tissue for boron neuron capture therapy. Uptake studies in tumor models other than melanoma now indicate that BPA is capable of delivering therapeutic amounts of boron to tumors other than melanoma. The KHJJ murine mammary tumor carried s.c. in BALB/c mice, the GS-9L rat glioma carried both s.c. and intracranially in F-344 rats, and the human U-87 MG glioma xenograft carried s.c. in nude mice have all shown significant accumulation of boron in tumor tissue following single p.o. (intragastric) doses of BPA. In this KHJJ mammary tumor, the L isomer of BPA was preferentially accumulated compared to the D isomer, indicative of a carrier-mediated transport process. Double-label, whole-body autoradiographic studies in a pigmented murine melanoma have shown that the boron distribution (from BPA) differs from the distribution of a tritiated melanin precursor (tyrosine). Boron accumulated only in the tumor; labeled tyrosine accumulated in tumor, liver, intestinal epithelium, bone-marrow, and secretory glands. Toxicity studies in mice and rabbits indicate that, even at very high doses, BPA p.o. caused no adverse effect in tissues, on blood chemistry, or on differential leukocyte counts. These data indicate that BPA may be generally useful as a boron delivery agent for boron neutron capture therapy of tumors. JF - Cancer research AU - Coderre, J A AU - Glass, J D AU - Fairchild, R G AU - Micca, P L AU - Fand, I AU - Joel, D D AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1990/01/01/ PY - 1990 DA - 1990 Jan 01 SP - 138 EP - 141 VL - 50 IS - 1 SN - 0008-5472, 0008-5472 KW - Boron Compounds KW - 0 KW - Drug Carriers KW - Isotopes KW - Phenylalanine KW - 47E5O17Y3R KW - 4-boronophenylalanine KW - UID84303EL KW - Index Medicus KW - Rats KW - Neutrons KW - Animals KW - Humans KW - Transplantation, Heterologous KW - Mice, Nude KW - Mice KW - Tissue Distribution KW - Mice, Inbred BALB C KW - Cell Line KW - Phenylalanine -- analogs & derivatives KW - Boron Compounds -- pharmacokinetics KW - Phenylalanine -- therapeutic use KW - Mammary Neoplasms, Experimental -- radiotherapy KW - Brain Neoplasms -- radiotherapy KW - Brain Neoplasms -- metabolism KW - Phenylalanine -- pharmacokinetics KW - Mammary Neoplasms, Experimental -- metabolism KW - Glioma -- metabolism KW - Boron Compounds -- therapeutic use KW - Glioma -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79533025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Selective+delivery+of+boron+by+the+melanin+precursor+analogue+p-boronophenylalanine+to+tumors+other+than+melanoma.&rft.au=Coderre%2C+J+A%3BGlass%2C+J+D%3BFairchild%2C+R+G%3BMicca%2C+P+L%3BFand%2C+I%3BJoel%2C+D+D&rft.aulast=Coderre&rft.aufirst=J&rft.date=1990-01-01&rft.volume=50&rft.issue=1&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-25 N1 - Date created - 1990-01-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - BOOK T1 - Transition metal complexes; theoretical studies of geometrical and electronic structure in relation to mechanisms for electron transfer AN - 50372254; 1993-005539 JF - V. M. Goldschmidt conference AU - Newton, Marshall AU - Anonymous Y1 - 1990 PY - 1990 DA - 1990 SP - 69 PB - Geochem. Soc. KW - theoretical studies KW - ligands KW - electron transfer KW - metals KW - oxidation KW - mechanism KW - kinetics KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50372254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Newton%2C+Marshall%3BAnonymous&rft.aulast=Newton&rft.aufirst=Marshall&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Transition+metal+complexes%3B+theoretical+studies+of+geometrical+and+electronic+structure+in+relation+to+mechanisms+for+electron+transfer&rft.title=Transition+metal+complexes%3B+theoretical+studies+of+geometrical+and+electronic+structure+in+relation+to+mechanisms+for+electron+transfer&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Geochemistry and source evaluation of aerosol particles at Grand Canyon National Park AN - 50370709; 1993-005512 JF - V. M. Goldschmidt conference AU - Mazurek, Monica A AU - Cass, Glen R AU - Jones, Michael AU - Salmon, Lynn AU - Winner, Darrell AU - Leach, Martin AU - Anonymous Y1 - 1990 PY - 1990 DA - 1990 SP - 64 PB - Geochem. Soc. KW - United States KW - visibility KW - human activity KW - pollution KW - Southwestern U.S. KW - Grand Canyon KW - sampling KW - Arizona KW - aerosols KW - air KW - particulate materials KW - geochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50370709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Mazurek%2C+Monica+A%3BCass%2C+Glen+R%3BJones%2C+Michael%3BSalmon%2C+Lynn%3BWinner%2C+Darrell%3BLeach%2C+Martin%3BAnonymous&rft.aulast=Mazurek&rft.aufirst=Monica&rft.date=1990-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Geochemistry+and+source+evaluation+of+aerosol+particles+at+Grand+Canyon+National+Park&rft.title=Geochemistry+and+source+evaluation+of+aerosol+particles+at+Grand+Canyon+National+Park&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Kr and Xe diffusion and solubility in silicate melts and glasses AN - 50330645; 1993-032492 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Carroll, M R AU - Sutton, S R AU - Woolum, D AU - Lewotsky, K AU - Rogers, P S Z Y1 - 1990 PY - 1990 DA - 1990 SP - 170 EP - 171 PB - Lunar and Planetary Science Conference, Houston, TX VL - 21 KW - silicates KW - experimental studies KW - diffusion KW - X-ray data KW - noble gases KW - solubility KW - xenon KW - krypton KW - melts KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50330645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Kr+and+Xe+diffusion+and+solubility+in+silicate+melts+and+glasses&rft.au=Carroll%2C+M+R%3BSutton%2C+S+R%3BWoolum%2C+D%3BLewotsky%2C+K%3BRogers%2C+P+S+Z&rft.aulast=Carroll&rft.aufirst=M&rft.date=1990-01-01&rft.volume=21&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-first lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 4 N1 - PubXState - TX N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - diffusion; experimental studies; krypton; melts; noble gases; silicates; solubility; X-ray data; xenon ER - TY - JOUR T1 - Petrography of meteoritic VLT basalt breccia (87521) from Elephant Moraine, Antarctica AN - 50326972; 1993-032544 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Delaney, Jeremy S AU - Sutton, S R Y1 - 1990 PY - 1990 DA - 1990 SP - 274 EP - 275 PB - Lunar and Planetary Science Conference, Houston, TX VL - 21 KW - breccia KW - stony meteorites KW - oxygen KW - isotopes KW - EET 87521 KW - Elephant Moraine Meteorites KW - O-18/O-16 KW - thin sections KW - Elephant Moraine KW - achondrites KW - stable isotopes KW - meteorites KW - sedimentary rocks KW - mineral composition KW - Antarctica KW - Victoria Land KW - petrography KW - clastic rocks KW - 05B:Petrology of meteorites and tektites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50326972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Petrography+of+meteoritic+VLT+basalt+breccia+%2887521%29+from+Elephant+Moraine%2C+Antarctica&rft.au=Delaney%2C+Jeremy+S%3BSutton%2C+S+R&rft.aulast=Delaney&rft.aufirst=Jeremy&rft.date=1990-01-01&rft.volume=21&rft.issue=&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-first lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1993-01-01 N1 - Number of references - 10 N1 - PubXState - TX N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - achondrites; Antarctica; breccia; clastic rocks; EET 87521; Elephant Moraine; Elephant Moraine Meteorites; isotopes; meteorites; mineral composition; O-18/O-16; oxygen; petrography; sedimentary rocks; stable isotopes; stony meteorites; thin sections; Victoria Land ER - TY - JOUR T1 - Anaerobic microbial remobilization of toxic metals coprecipitated with iron oxide AN - 13752333; 199003310 AB - An anaerobic nitrogen fixing Clostridium sp. was used to remobilize cadmium, chromium, nickel, lead and zinc coprecipitated with geothite (alpha-FeOOH). Remobilization by direct action due to enzymatic reduction to ferric iron and the release of metals associated with iron and by indirect action due to metabolic products and the lowering of the medium pH was studied. The extent of microbial remobilization of coprecipitated metals depended on the nature of the association of the metals with iron. Nickel and chromium were solubilized by both direct and indirect action. Lead was readily solubilized by indirect action. There is a bibliography of 31 references. JF - Environmental Science & Technology AU - Francis, A J AU - Dodge, C J AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1990 PY - 1990 DA - 1990 SP - 373 EP - 378 VL - 24 IS - 3 SN - 0013-936X, 0013-936X KW - Media KW - Pb KW - Aqualine Abstracts KW - AQ 00007:Industrial Effluents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13752333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Anaerobic+microbial+remobilization+of+toxic+metals+coprecipitated+with+iron+oxide&rft.au=Francis%2C+A+J%3BDodge%2C+C+J&rft.aulast=Francis&rft.aufirst=A&rft.date=1990-01-01&rft.volume=24&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Probabilistic approach to obtain hit-size effectiveness functions which relate microdosimetry and radiobiology. AN - 79374600; 2594965 AB - A probabilistic approach has been developed to relate microdosimetry, biological effects, and radiation quality. It is used to derive, and subsequently apply, microdosimetry-based cellular response functions for different biological end points of relevance for radiological protection. The approach makes use of measurable microdosimetry spectra and avoids assumptions concerning the course of mechanisms of radiation action. Instead, it postulates a response function that is, and behaves like, the cumulative probability that a subcellular target structure will respond to a specific target-averaged ionization density. Statistical distributions are applied and their parameters are evaluated to characterize the randomness involved in the localization of sensitive sites and in the reactivity of the whole sensitive structure. The resulting response functions can be used for prediction of the effects of low-level radiation. Such predictions for some selected effects of a stochastic nature (mutagenesis, chromosome abnormalities, etc.) are presented as relative biological effectiveness values based on low doses of radiations with a wide range of linear energy transfer and compared with various quality factor specifications. Cellular response relationships, termed hit-size effectiveness functions, can also be applied directly in radiation protection metrology by incorporating them into the software used to process the readings of microdosimetric spectrometers. The derivation of the functions, rather than their uses in radiation protection, is the principal subject of this report. JF - Radiation research AU - Morstin, K AU - Bond, V P AU - Baum, J W AD - Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1989/12// PY - 1989 DA - December 1989 SP - 383 EP - 402 VL - 120 IS - 3 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Animals KW - Radiometry KW - In Vitro Techniques KW - Chromosome Aberrations KW - Models, Statistical KW - Mutation KW - Models, Biological KW - Cricetinae KW - Cells -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79374600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Probabilistic+approach+to+obtain+hit-size+effectiveness+functions+which+relate+microdosimetry+and+radiobiology.&rft.au=Morstin%2C+K%3BBond%2C+V+P%3BBaum%2C+J+W&rft.aulast=Morstin&rft.aufirst=K&rft.date=1989-12-01&rft.volume=120&rft.issue=3&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1990-01-25 N1 - Date created - 1990-01-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Animal model for ultraviolet radiation-induced melanoma: platyfish-swordtail hybrid. AN - 79313419; 2813430 AB - Sunlight exposure is strongly indicated as one of the important etiologic agents in human cutaneous malignant melanoma. However, because of the absence of good animal models, it has not been possible to estimate the wavelengths or wavelength regions involved. We have developed a useful animal model from crosses and backcrosses of platyfish (Xiphophorus maculatus) and swordtails (Xiphophorus helleri). Two strains of these fish are susceptible to invasive melanoma induction by exposure to filtered radiation from sunlamps in the wavelength ranges lambda greater than 290 nm and lambda greater than 304 nm. Multiple exposures on 5-20 consecutive days beginning on day 5 after birth or a single exposure of approximately 200 J/(m2.day) of lambda greater than 304 nm result in a tumor prevalence of 20% to 40% at 4 months of age compared with a background rate of 12% in one strain and 2% in another. Exposure of the fish to visible light after UV exposure reduces the prevalence to background. The melanomas are similar in many respects to mammalian melanomas, as judged by light and electron microscopy. The genetics of the crosses determined by others and the high sensitivity of the hybrids to melanoma induction indicate that the UV radiation probably inactivates the one tumor repressor gene (or a small number of tumor repressor genes) in the hybrid fish. The small size of the animals and their high susceptibility to melanoma induction make them ideal for action spectroscopy. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Setlow, R B AU - Woodhead, A D AU - Grist, E AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 8922 EP - 8926 VL - 86 IS - 22 SN - 0027-8424, 0027-8424 KW - Index Medicus KW - Animals KW - Hybridization, Genetic KW - Cyprinodontiformes KW - Fishes KW - Crosses, Genetic KW - Microscopy, Electron KW - Skin Neoplasms -- genetics KW - Ultraviolet Rays KW - Neoplasms, Radiation-Induced -- pathology KW - Skin Neoplasms -- ultrastructure KW - Skin Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- ultrastructure KW - Skin Neoplasms -- pathology KW - Neoplasms, Radiation-Induced -- genetics KW - Melanoma, Experimental -- ultrastructure KW - Melanoma, Experimental -- pathology KW - Melanoma, Experimental -- genetics KW - Melanoma, Experimental -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79313419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Animal+model+for+ultraviolet+radiation-induced+melanoma%3A+platyfish-swordtail+hybrid.&rft.au=Setlow%2C+R+B%3BWoodhead%2C+A+D%3BGrist%2C+E&rft.aulast=Setlow&rft.aufirst=R&rft.date=1989-11-01&rft.volume=86&rft.issue=22&rft.spage=8922&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 1978 Sep 18;516(1):61-95 [361083] Photochem Photobiol. 1989 Jul;50(1):1-5 [2762379] Cancer Res. 1951 Sep;11(9):676-86 [14870128] J Exp Zool. 1971 Feb;176(2):147-68 [5559225] Annu Rev Biophys Bioeng. 1972;1:293-346 [4567755] J Natl Cancer Inst. 1976 Jul;57(1):211-5 [1003502] Natl Cancer Inst Monogr. 1978 Dec;(50):179-83 [753974] Cancer Res. 1980 Jun;40(6):1934-9 [7371028] Cancer Res. 1981 Jun;41(6):2211-4 [7237421] J Cancer Res Clin Oncol. 1984;107(1):21-31 [6699072] Carcinogenesis. 1984 Apr;5(4):511-4 [6705149] Adv Cancer Res. 1984;42:191-275 [6395655] Cell. 1988 Apr 22;53(2):173-4 [3282673] Cancer Res. 1988 Jun 15;48(12):3454-60 [3370642] Natl Cancer Inst Monogr. 1978 Dec;(50):129-32 [753970] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Increase in micronucleated erythrocytes associated with babesiosis in Syrian golden hamsters. AN - 79302769; 2811934 AB - The effect of infection by Babesia microti, a tick-borne piroplasm endemic to the northeastern United States, on the temporal pattern of micronucleated erythrocyte frequencies in peripheral blood was investigated in male Syrian golden hamsters. Significantly greater frequencies of micronucleated erythrocytes occurred in the blood of infected hamsters from 26 to 46 days after injection with B. microti, the magnitude of which within individual hamsters correlated highly with the percentage of polychromatic erythrocytes and the extent of parasitization. These data suggest that parasitic infection and other factors which alter the rate of erythropoiesis should be considered when the micronucleus assay is used in environmental or laboratory studies of genetic toxicity. JF - Mutation research AU - Ormiston, B G AU - Luke, C A AU - Tice, R R AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 173 EP - 177 VL - 227 IS - 3 SN - 0027-5107, 0027-5107 KW - Index Medicus KW - Animals KW - Mesocricetus KW - Male KW - Cricetinae KW - Erythrocytes -- ultrastructure KW - Micronucleus Tests KW - Babesiosis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79302769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Increase+in+micronucleated+erythrocytes+associated+with+babesiosis+in+Syrian+golden+hamsters.&rft.au=Ormiston%2C+B+G%3BLuke%2C+C+A%3BTice%2C+R+R&rft.aulast=Ormiston&rft.aufirst=B&rft.date=1989-11-01&rft.volume=227&rft.issue=3&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-06 N1 - Date created - 1989-12-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - The effect of agent dose and treatment time on the intercellular distribution of sister-chromatid exchanges induced by genotoxic agents in mouse bone marrow cells in vivo. AN - 79295888; 2509900 AB - Using two methods of bromodeoxyuridine (BrdUrd) administration and three genotoxic chemicals, the effects of dose and treatment time on the intercellular distribution of sister-chromatid exchanges (SCE) in the bone marrow of male B6C3F1 mice were evaluated. The dispersion of SCE among solvent control mice infused intravenously with BrdUrd or implanted subcutaneously with a BrdUrd tablet partially coated with paraffin was largely consistent with a Poisson model. Intraperitoneal treatment with cyclophosphamide (CP; solvent = phosphate-buffered saline), 7,12-dimethylbenzanthracene (DMBA; solvent = corn oil) and, in mice infused with BrdUrd, mitomycin C (MMC; solvent = phosphate-buffered saline) induced a significant increase in SCE, the distribution of which was not distributed as a Poisson. For CP and MMC, the increase in dispersion was dose-dependent and independent of treatment time (-1, +1 or +8 h in relation to the start of the BrdUrd treatment). The lack of a treatment time effect suggests that there were no significant differences among treatment times in the distribution of the reactive forms of these two chemicals, no variation in cell-stage sensitivity, and no cellular toxicity to modulate the response. For DMBA, the increased dispersion of induced SCE depended on treatment time and was not simply related to dose. The increase in dispersion was agent-specific; at equal levels of SCE induction, the distribution of SCE in mice treated with DMBA exhibited greater dispersion than SCE in mice treated with either CP or MMC. These differences between DMBA and CP/MMC are probably due to DMBA's slower absorption/distribution kinetics, its requirement for metabolic activation to genotoxic metabolites and its extended half-life. These data suggest that analyzing the distribution of SCE, in addition to mean frequency, is a useful method for evaluating agent specific patterns in SCE induction. JF - Mutation research AU - Tice, R R AU - Ormiston, B G AU - McFee, A F AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989/11// PY - 1989 DA - November 1989 SP - 25 EP - 37 VL - 215 IS - 1 SN - 0027-5107, 0027-5107 KW - Mitomycins KW - 0 KW - Mutagens KW - Mitomycin KW - 50SG953SK6 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Cyclophosphamide KW - 8N3DW7272P KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Bone Marrow Cells KW - Mice, Inbred Strains KW - Animals KW - Dose-Response Relationship, Drug KW - Mice KW - Male KW - 9,10-Dimethyl-1,2-benzanthracene -- pharmacology KW - Sister Chromatid Exchange -- drug effects KW - Mitomycins -- pharmacology KW - Bone Marrow -- drug effects KW - Cyclophosphamide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79295888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+effect+of+agent+dose+and+treatment+time+on+the+intercellular+distribution+of+sister-chromatid+exchanges+induced+by+genotoxic+agents+in+mouse+bone+marrow+cells+in+vivo.&rft.au=Tice%2C+R+R%3BOrmiston%2C+B+G%3BMcFee%2C+A+F&rft.aulast=Tice&rft.aufirst=R&rft.date=1989-11-01&rft.volume=215&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-12-21 N1 - Date created - 1989-12-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - A plasmid carrying mucA and mucB genes from pKM101 in Haemophilus influenzae and Escherichia coli. AN - 79236106; 2676992 AB - The plasmid pMucAMucB, constructed from the Haemophilus influenzae vector pDM2, and a similar plasmid, constructed from pBR322, increased the survival after UV irradiation of Escherichia coli AB1157 with the umu-36 mutation and also caused UV-induced mutation in the E. coli strain. In H. influenzae, pMucAMucB caused a small but reproducible increase in survival after UV irradiation in wild-type cells and in a rec-1 mutant, but there was no increase in spontaneous mutation in the wild type or in the rec-1 mutant and no UV-induced mutation. JF - Journal of bacteriology AU - Spikes, D AU - Setlow, J K AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1989/10// PY - 1989 DA - October 1989 SP - 5753 EP - 5755 VL - 171 IS - 10 SN - 0021-9193, 0021-9193 KW - Index Medicus KW - Ultraviolet Rays KW - Dose-Response Relationship, Radiation KW - Genes, Bacterial KW - Haemophilus influenzae -- genetics KW - Escherichia coli -- genetics KW - Plasmids KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79236106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=A+plasmid+carrying+mucA+and+mucB+genes+from+pKM101+in+Haemophilus+influenzae+and+Escherichia+coli.&rft.au=Spikes%2C+D%3BSetlow%2C+J+K&rft.aulast=Spikes&rft.aufirst=D&rft.date=1989-10-01&rft.volume=171&rft.issue=10&rft.spage=5753&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-03 N1 - Date created - 1989-11-03 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: J Bacteriol. 1973 Jul;115(1):153-61 [4541535] Proc Natl Acad Sci U S A. 1988 Mar;85(6):1816-20 [3279418] J Bacteriol. 1988 Sep;170(9):3876-81 [3045079] Mutat Res. 1977 Aug;44(2):183-96 [302410] J Bacteriol. 1980 Jul;143(1):516-9 [6967485] Mol Gen Genet. 1980;179(2):289-97 [6258013] Plasmid. 1981 Mar;5(2):188-201 [6264522] J Bacteriol. 1981 Dec;148(3):812-6 [6975775] J Bacteriol. 1982 Sep;151(3):1605-7 [6286603] Nature. 1982 Nov 18;300(5889):278-81 [6755263] J Mol Biol. 1983 Feb 25;164(2):175-92 [6302271] Gene. 1983 Aug;23(2):167-74 [6311684] Proc Natl Acad Sci U S A. 1985 Jul;82(13):4331-5 [2989816] Proc Natl Acad Sci U S A. 1985 Nov;82(22):7753-6 [3877933] J Bacteriol. 1968 Nov;96(5):1718-24 [5303721] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Effect of processing time on the quality of mouse bone-marrow metaphase preparations. AN - 79192852; 2770777 AB - To evaluate the effect of extended incubation in phosphate-buffered saline (PBS) on the quality of mouse bone-marrow metaphase preparations, bone-marrow samples were allowed to stand in PBS at room temperature for from 15 min to 3 h before hypotonic treatment and fixation. The frequencies of sister-chromatid exchanges, the rate of cellular proliferation and the mitotic indices in these mice were not significantly affected by prolonged storage in PBS. However, slide quality decreased significantly in bone-marrow samples stored in PBS for more than 2 h. These data demonstrate that the storage of bone-marrow samples in PBS at room temperature for at least 1 h does not adversely affect the quality of routine cytogenetic data, making it more feasible to conduct studies involving large numbers of animals. JF - Mutation research AU - Luke, C A AU - Tice, R R AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989/09// PY - 1989 DA - September 1989 SP - 59 EP - 62 VL - 227 IS - 1 SN - 0027-5107, 0027-5107 KW - Buffers KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - Animals KW - Sister Chromatid Exchange -- drug effects KW - Specimen Handling KW - Mitotic Index KW - Mice KW - Buffers -- pharmacology KW - Time Factors KW - Male KW - Cell Cycle -- drug effects KW - Sodium Chloride -- pharmacology KW - Karyotyping -- methods KW - Mutagenicity Tests -- methods KW - Bone Marrow -- ultrastructure KW - Bone Marrow -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79192852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Effect+of+processing+time+on+the+quality+of+mouse+bone-marrow+metaphase+preparations.&rft.au=Luke%2C+C+A%3BTice%2C+R+R&rft.aulast=Luke&rft.aufirst=C&rft.date=1989-09-01&rft.volume=227&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-06 N1 - Date created - 1989-10-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Time course of enhancement of chromosomal aberration production in human lymphocytes by post-treatment with aphidicolin following X-irradiation in G2. AN - 79140475; 2503716 JF - Mutation research AU - Bender, M A AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989/08// PY - 1989 DA - August 1989 SP - 175 EP - 183 VL - 213 IS - 2 SN - 0027-5107, 0027-5107 KW - Diterpenes KW - 0 KW - Aphidicolin KW - 38966-21-1 KW - DNA Polymerase II KW - EC 2.7.7.- KW - Index Medicus KW - Humans KW - Interphase KW - Diterpenes -- toxicity KW - Lymphocytes -- radiation effects KW - DNA Polymerase II -- antagonists & inhibitors KW - Chromosome Aberrations KW - Cell Division -- drug effects KW - Lymphocytes -- ultrastructure KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79140475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Time+course+of+enhancement+of+chromosomal+aberration+production+in+human+lymphocytes+by+post-treatment+with+aphidicolin+following+X-irradiation+in+G2.&rft.au=Bender%2C+M+A&rft.aulast=Bender&rft.aufirst=M&rft.date=1989-08-01&rft.volume=213&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-09-13 N1 - Date created - 1989-09-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Hematotoxicity and carcinogenicity of inhaled benzene. AN - 79226895; 2792054 AB - CBA/Ca male mice have been exposed to benzene in air at 10, 25, 100, 300, 400, and 3000 ppm for variable intervals 6 hr/day, 5 days/week for up to 16 weeks. Two weeks of inhaling 10 ppm produced no hematologic effects; 25 ppm induced a significant lymphopenia. Inhalation of 100, 300, and 400 ppm produced dose-dependent decreases in blood lymphocytes, bone marrow cellularity, marrow content of spleen colony-forming units (CFU-S) and an increased fraction of CFU-S in DNA synthesis. Exposure of mice to 300 ppm for 2, 4, 8, and 16 weeks produced severe lymphopenia and decrease in marrow CFU-S. Recovery was rapid and complete after 2 and 4 weeks of exposure. After 8 and 16 weeks of exposure, recovery of lymphocytes was complete within 8 weeks. It took 16 weeks for the CFU-S to recover to that of the age-matched controls after 8 weeks of exposure and 25 weeks to recover to age-matched after 16 weeks of exposure. Inhalation of 3000 ppm for 8 days was less damaging than inhalation of 300 ppm for 80 days (same integral amount of benzene inhaled). The inhalation of 3000 ppm has not increased the incidence of leukemia or shortened its latency for development. Inhalation of 300 ppm 6 hr/day for 16 weeks significantly increases the incidence of myelogenous neoplasms in male CBA/Ca mice. Inhalation of 100 ppm for same interval does not influence incidence of myelogenous neoplasms but does increase incidence of solid neoplasms particularly in female CBA/Ca mice. Benzene is a potent carcinogen in CBA/Ca mice. JF - Environmental health perspectives AU - Cronkite, E P AU - Drew, R T AU - Inoue, T AU - Hirabayashi, Y AU - Bullis, J E AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 97 EP - 108 VL - 82 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Benzene KW - J64922108F KW - Index Medicus KW - Erythrocytes -- drug effects KW - Animals KW - Mice, Inbred CBA KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Neutropenia -- chemically induced KW - Mice KW - Administration, Inhalation KW - Male KW - Female KW - Hematopoietic Stem Cells -- drug effects KW - Hematologic Diseases -- chemically induced KW - Benzene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79226895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Hematotoxicity+and+carcinogenicity+of+inhaled+benzene.&rft.au=Cronkite%2C+E+P%3BDrew%2C+R+T%3BInoue%2C+T%3BHirabayashi%2C+Y%3BBullis%2C+J+E&rft.aulast=Cronkite&rft.aufirst=E&rft.date=1989-07-01&rft.volume=82&rft.issue=&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-02 N1 - Date created - 1989-11-02 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Acta Haematol. 1967;38(2):104-11 [4963575] Arch Environ Health. 1968 Feb;16(2):194-206 [4171547] Radiat Res. 1970 Mar;41(3):467-91 [4908840] Br J Ind Med. 1971 Jul;28(3):296-302 [5557851] Blood. 1974 Oct;44(4):517-34 [4137721] Blood. 1974 Dec;44(6):837-41 [4529630] Acta Haematol. 1976;55(2):65-72 [816144] Transplantation. 1976 Sep;22(3):287-93 [788254] J Immunol. 1977 Apr;118(4):1223-7 [15033] Toxicol Appl Pharmacol. 1977 Apr;40(1):49-57 [867432] Proc Natl Acad Sci U S A. 1977 Sep;74(9):3879-82 [269439] Nature. 1978 Mar 30;272(5652):455-6 [273147] J Exp Med. 1978 May 1;147(5):1526-31 [25943] Mech Ageing Dev. 1979 Mar;9(5-6):427-33 [37377] J Natl Cancer Inst. 1979 Sep;63(3):843-8 [288938] Toxicology. 1980;16(2):163-71 [7414616] Toxicol Appl Pharmacol. 1980 Jun 30;54(2):323-31 [6893503] Toxicol Appl Pharmacol. 1981 Sep 15;60(2):346-53 [7281193] Cancer Res. 1982 Feb;42(2):433-6 [7055798] J Exp Med. 1982 Feb 1;155(2):432-44 [7035599] Blood. 1982 Jul;60(1):245-52 [7082840] J Toxicol Environ Health. 1982 Mar;9(3):411-21 [7097795] Am J Ind Med. 1981;2(3):217-45 [7345926] Toxicol Lett. 1982 Oct;13(3-4):169-73 [6959383] Science. 1983 Mar 4;219(4588):1032-7 [6823565] Stem Cells. 1982;2(1):45-58 [6760412] Exp Hematol. 1983 Sep;11(8):762-71 [6138275] Environ Health Perspect. 1983 Oct;52:75-82 [6653540] Toxicol Lett. 1984 Mar;20(3):337-42 [6701920] Am J Ind Med. 1984;5(6):429-34 [6731444] Leuk Res. 1985;9(12):1519-28 [3866124] N Engl J Med. 1964 Oct 22;271:872-6 [14185112] Blood. 1965 Sep;26:296-308 [14332057] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Effect of exposure route, regimen, and duration on benzene-induced genotoxic and cytotoxic bone marrow damage in mice. AN - 79226375; 2792052 AB - Mice were exposed to benzene for 13 to 14 weeks by inhalation for either 3 or 5 consecutive days per week or by gavage for 5 consecutive days per week. A weekly evaluation of peripheral blood smears for micronucleated (MN) erythrocyte frequencies and for the percentage of polychromatic erythrocytes (PCE) indicated that the induction of MN-PCE by benzene depended on the sex and strain of mice and on the route of exposure, but not on the inhalation regimen or on the exposure duration. The frequency of MN normochromatic erythrocytes (NCE) not only depended on the sex and strain of mice and on the route of exposure, but directly depended on the inhalation regimen and on the exposure duration. Similarly, the extent of erythropoietic depression in benzene-exposed mice was dependent on sex, mouse strain, exposure duration, and route. However, in contrast to the MN-NCE data, the 3 day/week exposure regimen induced a more persistent depression in erythropoiesis than the 5 day/week exposure regimen. Exposure to benzene also induced in mice a significant depression in packed cell volume (PCV) and bone marrow cellularity, the magnitude of which depended on the sex and strain of mice and on the regimen and route of exposure. JF - Environmental health perspectives AU - Tice, R R AU - Luke, C A AU - Drew, R T AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989/07// PY - 1989 DA - July 1989 SP - 65 EP - 74 VL - 82 SN - 0091-6765, 0091-6765 KW - Mutagens KW - 0 KW - Benzene KW - J64922108F KW - Index Medicus KW - Administration, Oral KW - Erythrocytes -- drug effects KW - Animals KW - Drug Administration Schedule KW - Micronucleus Tests KW - Mice, Inbred C57BL KW - Hematocrit KW - Mice KW - Administration, Inhalation KW - Male KW - Female KW - Mice, Inbred DBA KW - Benzene -- administration & dosage KW - Bone Marrow Diseases -- pathology KW - Bone Marrow Diseases -- chemically induced KW - Benzene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79226375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Effect+of+exposure+route%2C+regimen%2C+and+duration+on+benzene-induced+genotoxic+and+cytotoxic+bone+marrow+damage+in+mice.&rft.au=Tice%2C+R+R%3BLuke%2C+C+A%3BDrew%2C+R+T&rft.aulast=Tice&rft.aufirst=R&rft.date=1989-07-01&rft.volume=82&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-11-02 N1 - Date created - 1989-11-02 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Environ Health Perspect. 1989 Jul;82:9-17 [2792053] Mutat Res. 1978;47(2):75-97 [415231] Toxicol Appl Pharmacol. 1980 Jun 30;54(2):323-31 [6893503] Med Lav. 1979 Sep-Oct;70(5):352-7 [554913] Toxicol Appl Pharmacol. 1981 Feb;57(2):164-71 [7222032] Toxicol Appl Pharmacol. 1981 Jun 30;59(2):204-14 [7256764] Toxicol Appl Pharmacol. 1981 Sep 30;60(3):398-409 [7292478] Environ Mutagen. 1980;2(4):509-14 [6796407] Mutat Res. 1982 Jul;104(6):367-9 [7110171] Mutat Res. 1983 Sep;123(1):61-118 [6888413] J Toxicol Environ Health. 1983 Apr-Jun;11(4-6):811-25 [6620413] Toxicol Appl Pharmacol. 1984 May;73(3):525-32 [6719467] Mutat Res. 1984 Jul;127(2):129-37 [6431276] Toxicol Appl Pharmacol. 1984 Sep 15;75(2):358-61 [6474468] Toxicol Appl Pharmacol. 1973 Nov;26(3):398-406 [4148939] Mutat Res. 1985 May-Jun;143(1-2):55-9 [4000143] Am J Ind Med. 1985;8(1):9-20 [4025342] Mutat Res. 1985 Nov;154(3):153-81 [3930957] Mutat Res. 1985 Nov;144(3):193-6 [4058438] Toxicol Appl Pharmacol. 1986 Feb;82(2):272-80 [3080823] Toxicol Appl Pharmacol. 1987 Feb;87(2):325-36 [3824388] Mutat Res. 1987 Jul;179(1):23-31 [3037363] Mutat Res. 1988 Aug;203(4):251-71 [3405235] Mutat Res. 1988 Aug;203(4):273-95 [3405236] J Toxicol Environ Health. 1978 Jul;4(4):605-18 [682210] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Radiation absorbed dose from technetium-99m-labeled bone imaging agents. Task Group of the Medical Internal Radiation Dose Committee, The Society of Nuclear Medicine. AN - 79072144; 2544697 JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Weber, D A AU - Makler, P T AU - Watson, E E AU - Coffey, J L AU - Thomas, S R AU - London, J AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989/06// PY - 1989 DA - June 1989 SP - 1117 EP - 1122 VL - 30 IS - 6 SN - 0161-5505, 0161-5505 KW - Diphosphates KW - 0 KW - Organotechnetium Compounds KW - technetium Tc 99m etidronate KW - 13W7DMI45X KW - Technetium Tc 99m Pyrophosphate KW - 5L76I61H2B KW - technetium Tc 99m hydroxymethylene diphosphonate KW - 72945-61-0 KW - Technetium KW - 7440-26-8 KW - Etidronic Acid KW - M2F465ROXU KW - Technetium Tc 99m Medronate KW - X89XV46R07 KW - Index Medicus KW - Technetium Tc 99m Medronate -- analogs & derivatives KW - Humans KW - Radionuclide Imaging KW - Radiation Dosage KW - Bone and Bones -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79072144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Radiation+absorbed+dose+from+technetium-99m-labeled+bone+imaging+agents.+Task+Group+of+the+Medical+Internal+Radiation+Dose+Committee%2C+The+Society+of+Nuclear+Medicine.&rft.au=Weber%2C+D+A%3BMakler%2C+P+T%3BWatson%2C+E+E%3BCoffey%2C+J+L%3BThomas%2C+S+R%3BLondon%2C+J&rft.aulast=Weber&rft.aufirst=D&rft.date=1989-06-01&rft.volume=30&rft.issue=6&rft.spage=1117&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-03 N1 - Date created - 1989-08-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Prophylaxis of cyanobacterial and mushroom cyclic peptide toxins. AN - 79017353; 2724139 AB - The pathogenicity of virulent cyclic peptide toxins of the cyanobacterium, Microcystis aeruginosa, and the mushroom, Amanita phalloides, was prevented in mice by pretreatment with a variety of chemically unrelated agents including hydrocortisone, shellac, certain diazo and triazine dyes and cyclosporine. A. Despite the diverse nature of the protective agents, a feature commonly associated with protection was the ability to impair hepatic uptake of 51Cr-labeled sheep erythrocytes, a function of hepatic macrophages (Kupffer cells). In addition, several of the protective agents are known to affect other aspects of reticuloendothelial cell function. Therefore it seems likely that the hepatic macrophage is involved in the observed protection, although by what mechanism(s) is unknown. The most remarkable prophylaxis was seen with a single injection of Trypan red, which provided nonimmunologic protection against a lethal dose of a cyanobacterial toxin, cyanoginosin-LR, for periods up to 3 months. JF - The Journal of pharmacology and experimental therapeutics AU - Adams, W H AU - Stoner, R D AU - Adams, D G AU - Read, H AU - Slatkin, D N AU - Siegelman, H W AD - Department of Medicine, Brookhaven National Laboratory, Upton, New York. Y1 - 1989/05// PY - 1989 DA - May 1989 SP - 552 EP - 556 VL - 249 IS - 2 SN - 0022-3565, 0022-3565 KW - Amanitins KW - 0 KW - Coloring Agents KW - Cyclosporins KW - Microcystins KW - Oligopeptides KW - Peptides, Cyclic KW - chinese ink KW - Phalloidine KW - 17466-45-4 KW - Carbon KW - 7440-44-0 KW - cyanoginosin-LA KW - 96180-79-9 KW - Trypan Blue KW - I2ZWO3LS3M KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Hydrocortisone -- pharmacology KW - Animals KW - Coloring Agents -- pharmacology KW - Trypan Blue -- pharmacology KW - Mice, Inbred C57BL KW - Macrophages -- physiology KW - Mice KW - Cyclosporins -- pharmacology KW - Male KW - Female KW - Amanitins -- poisoning KW - Oligopeptides -- poisoning KW - Phalloidine -- poisoning KW - Peptides, Cyclic -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79017353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Prophylaxis+of+cyanobacterial+and+mushroom+cyclic+peptide+toxins.&rft.au=Adams%2C+W+H%3BStoner%2C+R+D%3BAdams%2C+D+G%3BRead%2C+H%3BSlatkin%2C+D+N%3BSiegelman%2C+H+W&rft.aulast=Adams&rft.aufirst=W&rft.date=1989-05-01&rft.volume=249&rft.issue=2&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-26 N1 - Date created - 1989-06-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Dose inhomogeneities at various levels of biological organization. AN - 78899826; 2928945 JF - Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] AU - Bond, V P AD - Medical Department, Brookhaven National Laboratory, Upton, New York. PY - 1989 SP - 182 EP - 185 VL - 165 IS - 2-3 SN - 0179-7158, 0179-7158 KW - Isotopes KW - 0 KW - Boron KW - N9E3X5056Q KW - Index Medicus KW - Radiation Dosage KW - Animals KW - Mice KW - Neutrons KW - Cell Survival -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78899826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Strahlentherapie+und+Onkologie+%3A+Organ+der+Deutschen+Rontgengesellschaft+...+%5Bet+al%5D&rft.atitle=Dose+inhomogeneities+at+various+levels+of+biological+organization.&rft.au=Bond%2C+V+P&rft.aulast=Bond&rft.aufirst=V&rft.date=1989-02-01&rft.volume=165&rft.issue=2-3&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Strahlentherapie+und+Onkologie+%3A+Organ+der+Deutschen+Rontgengesellschaft+...+%5Bet+al%5D&rft.issn=01797158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-05-05 N1 - Date created - 1989-05-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - The effects of single L-amino acid substitutions on the lethal potencies of the microcystins. AN - 79210106; 2506678 AB - Microcystin-LR and -LA are more toxic than microcystin-LY and -RR in adult mice. They induce different degrees of thrombocytopenia and leukopenia, and the lethalities of their binary and ternary mixtures are addictive. Postnatal mice are resistant to doses of microcystin-LR that are lethal to adults but they are susceptible to higher doses. Substitution of a single L-amino acid for another in a microcystin markedly affects the dosimetric potency, but not the pathophysiology of its toxicity. JF - Toxicon : official journal of the International Society on Toxinology AU - Stoner, R D AU - Adams, W H AU - Slatkin, D N AU - Siegelman, H W AD - Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989 PY - 1989 DA - 1989 SP - 825 EP - 828 VL - 27 IS - 7 SN - 0041-0101, 0041-0101 KW - Amino Acids KW - 0 KW - Bacterial Toxins KW - Marine Toxins KW - Microcystins KW - cyanobacterial toxin KW - Index Medicus KW - Injections, Intraperitoneal KW - Animals KW - Aging KW - Lethal Dose 50 KW - Mice KW - Animals, Newborn -- physiology KW - Marine Toxins -- analysis KW - Cyanobacteria -- analysis KW - Marine Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79210106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=The+effects+of+single+L-amino+acid+substitutions+on+the+lethal+potencies+of+the+microcystins.&rft.au=Stoner%2C+R+D%3BAdams%2C+W+H%3BSlatkin%2C+D+N%3BSiegelman%2C+H+W&rft.aulast=Stoner&rft.aufirst=R&rft.date=1989-01-01&rft.volume=27&rft.issue=7&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-10-20 N1 - Date created - 1989-10-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Survival assays with a boronated porphyrin as measured with hamster V-79 cells in culture. AN - 79096059; 2751611 JF - Basic life sciences AU - Laster, B H AU - Kahl, S B AU - Popenoe, E A AU - Gordon, C AU - Kalef-Ezra, J AU - Fairchild, R G AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989 PY - 1989 DA - 1989 SP - 213 EP - 218 VL - 50 SN - 0090-5542, 0090-5542 KW - Boron Compounds KW - 0 KW - Porphyrins KW - Index Medicus KW - Neutrons KW - Animals KW - Dose-Response Relationship, Radiation KW - Cell Line KW - Cricetinae KW - Boron Compounds -- pharmacology KW - Cell Survival -- drug effects KW - Cell Survival -- radiation effects KW - Porphyrins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79096059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Survival+assays+with+a+boronated+porphyrin+as+measured+with+hamster+V-79+cells+in+culture.&rft.au=Laster%2C+B+H%3BKahl%2C+S+B%3BPopenoe%2C+E+A%3BGordon%2C+C%3BKalef-Ezra%2C+J%3BFairchild%2C+R+G&rft.aulast=Laster&rft.aufirst=B&rft.date=1989-01-01&rft.volume=50&rft.issue=&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-18 N1 - Date created - 1989-08-18 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Distributions of sulfhydryl borane monomer and dimer in rodents and monomer in humans: boron neutron capture therapy of melanoma and glioma in boronated rodents. AN - 79094275; 2751607 JF - Basic life sciences AU - Slatkin, D N AU - Joel, D D AU - Fairchild, R G AU - Micca, P L AU - Nawrocky, M M AU - Laster, B H AU - Coderre, J A AU - Finkel, G C AU - Poletti, C E AU - Sweet, W H AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1989 PY - 1989 DA - 1989 SP - 179 EP - 191 VL - 50 SN - 0090-5542, 0090-5542 KW - Boranes KW - 0 KW - Borohydrides KW - Isotopes KW - Sulfhydryl Compounds KW - Sulfides KW - mercaptoundecahydrododecaborate KW - 12294-22-3 KW - sulfhydryl borane dimer KW - 62962-06-5 KW - Index Medicus KW - Rats KW - Neutrons KW - Animals KW - Humans KW - Radiotherapy -- methods KW - Mice KW - Tissue Distribution KW - Mice, Inbred BALB C KW - Melanoma, Experimental -- radiotherapy KW - Sulfides -- pharmacokinetics KW - Sulfhydryl Compounds -- pharmacokinetics KW - Brain Neoplasms -- radiotherapy KW - Borohydrides -- therapeutic use KW - Borohydrides -- pharmacokinetics KW - Sulfides -- therapeutic use KW - Boranes -- pharmacokinetics KW - Sulfides -- toxicity KW - Boranes -- toxicity KW - Sulfhydryl Compounds -- therapeutic use KW - Glioma -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79094275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Distributions+of+sulfhydryl+borane+monomer+and+dimer+in+rodents+and+monomer+in+humans%3A+boron+neutron+capture+therapy+of+melanoma+and+glioma+in+boronated+rodents.&rft.au=Slatkin%2C+D+N%3BJoel%2C+D+D%3BFairchild%2C+R+G%3BMicca%2C+P+L%3BNawrocky%2C+M+M%3BLaster%2C+B+H%3BCoderre%2C+J+A%3BFinkel%2C+G+C%3BPoletti%2C+C+E%3BSweet%2C+W+H&rft.aulast=Slatkin&rft.aufirst=D&rft.date=1989-01-01&rft.volume=50&rft.issue=&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-08-18 N1 - Date created - 1989-08-18 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - The interactions between MnO2+/Mn3+ complexes and ascorbates. A pulse radiolysis study. AN - 78925006; 2707619 AB - The reactivity between various MnO2+/Mn3+ complexes and ascorbic acid/ascorbate were studied using pulse radiolysis. Experimental results indicate that Mn3+-sulfate reacts with both AH2/AH- via metal-ascorbate complexes. MnO2+-formate and Mn3+-pyrophosphate both appear to react by electron transfer with no evidence of complex formation. All of these metal complexes, with the exception of Mn3+-pyrophosphate, react as fast or faster with ascorbate than free O2-. The significance of this observation in light of metal-induced oxygen toxicity will be discussed. JF - Free radical biology & medicine AU - Cabelli, D E AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1989 PY - 1989 DA - 1989 SP - 171 EP - 177 VL - 6 IS - 2 SN - 0891-5849, 0891-5849 KW - Cations KW - 0 KW - Formates KW - Manganese Compounds KW - Oxides KW - Phosphates KW - Solutions KW - Sulfates KW - formic acid KW - 0YIW783RG1 KW - Manganese KW - 42Z2K6ZL8P KW - Ascorbic Acid KW - PQ6CK8PD0R KW - manganese dioxide KW - TF219GU161 KW - manganese sulfate KW - W00LYS4T26 KW - Index Medicus KW - Oxidation-Reduction KW - Kinetics KW - Hydrogen-Ion Concentration KW - Spectrophotometry KW - Spectrum Analysis KW - Pulse Radiolysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78925006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=The+interactions+between+MnO2%2B%2FMn3%2B+complexes+and+ascorbates.+A+pulse+radiolysis+study.&rft.au=Cabelli%2C+D+E&rft.aulast=Cabelli&rft.aufirst=D&rft.date=1989-01-01&rft.volume=6&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-06-05 N1 - Date created - 1989-06-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Great earthquake potential in Oregon and Washington; an overview of recent coastal geologic studies and possible segmentation of the central Cascadia subduction zone AN - 50537574; 1991-054008 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Nelson, Alan R AU - Personius, Stephen F Y1 - 1989 PY - 1989 DA - 1989 SP - 367 EP - 392 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - United States KW - Washington KW - subduction zones KW - seismology KW - magnitude KW - land subsidence KW - deformation KW - Oregon KW - plate tectonics KW - tectonophysics KW - seismicity KW - Cascadia subduction zone KW - earthquakes KW - 18:Solid-earth geophysics KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50537574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Great+earthquake+potential+in+Oregon+and+Washington%3B+an+overview+of+recent+coastal+geologic+studies+and+possible+segmentation+of+the+central+Cascadia+subduction+zone&rft.au=Nelson%2C+Alan+R%3BPersonius%2C+Stephen+F&rft.aulast=Nelson&rft.aufirst=Alan&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Seventeenth Water reactor safety information meeting; Volume 2 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1991-01-01 N1 - Number of references - 134 N1 - PubXState - DC N1 - Document feature - sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Cascadia subduction zone; deformation; earthquakes; land subsidence; magnitude; Oregon; plate tectonics; seismicity; seismology; subduction zones; tectonophysics; United States; Washington ER - TY - JOUR T1 - Paleoliquefaction investigations along the Atlantic seaboard, implications for long-term seismic hazard AN - 50537525; 1991-054006 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Amick, D AU - Gelinas, R AU - Maurath, G AU - Cannon, R Y1 - 1989 PY - 1989 DA - 1989 SP - 315 EP - 340 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - United States KW - seismology KW - geophysical surveys KW - seismicity KW - surveys KW - Eastern U.S. KW - research KW - liquefaction KW - earthquakes KW - remote sensing KW - Atlantic Coastal Plain KW - 19:Seismology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50537525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Paleoliquefaction+investigations+along+the+Atlantic+seaboard%2C+implications+for+long-term+seismic+hazard&rft.au=Amick%2C+D%3BGelinas%2C+R%3BMaurath%2C+G%3BCannon%2C+R&rft.aulast=Amick&rft.aufirst=D&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Seventeenth Water reactor safety information meeting; Volume 2 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1991-01-01 N1 - Number of references - 14 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table, sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Atlantic Coastal Plain; earthquakes; Eastern U.S.; geophysical surveys; liquefaction; remote sensing; research; seismicity; seismology; surveys; United States ER - TY - JOUR T1 - The 1886 Charleston earthquake; an overview of geological studies AN - 50537478; 1991-054005 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Weems, Robert E AU - Obermeier, Stephen F Y1 - 1989 PY - 1989 DA - 1989 SP - 289 EP - 313 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - United States KW - P-waves KW - South Carolina KW - seismic intensity KW - Ashley Formation KW - elastic waves KW - liquefaction KW - Cenozoic KW - seismicity KW - faults KW - Atlantic Coastal Plain KW - body waves KW - middle Eocene KW - seismology KW - Eocene KW - Charleston earthquake 1886 KW - Santee Limestone KW - basement KW - effects KW - Paleogene KW - Tertiary KW - seismic waves KW - earthquakes KW - Oligocene KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50537478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=The+1886+Charleston+earthquake%3B+an+overview+of+geological+studies&rft.au=Weems%2C+Robert+E%3BObermeier%2C+Stephen+F&rft.aulast=Weems&rft.aufirst=Robert&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Seventeenth Water reactor safety information meeting; Volume 2 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1991-01-01 N1 - Number of references - 41 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Ashley Formation; Atlantic Coastal Plain; basement; body waves; Cenozoic; Charleston earthquake 1886; earthquakes; effects; elastic waves; Eocene; faults; liquefaction; middle Eocene; Oligocene; P-waves; Paleogene; Santee Limestone; seismic intensity; seismic waves; seismicity; seismology; South Carolina; Tertiary; United States ER - TY - JOUR T1 - Overview of NRC earth science research AN - 50537274; 1991-054004 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - McMullen, R AU - Zurflueh, E G AU - Murphy, A Y1 - 1989 PY - 1989 DA - 1989 SP - 283 EP - 288 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - United States KW - U. S. Nuclear Regulatory Commission KW - seismology KW - ground motion KW - government agencies KW - research KW - earthquakes KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50537274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Overview+of+NRC+earth+science+research&rft.au=McMullen%2C+R%3BZurflueh%2C+E+G%3BMurphy%2C+A&rft.aulast=McMullen&rft.aufirst=R&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Seventeenth Water reactor safety information meeting; Volume 2 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1991-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - earthquakes; government agencies; ground motion; research; seismology; U. S. Nuclear Regulatory Commission; United States ER - TY - JOUR T1 - Seventeenth Water reactor safety information meeting; Volume 2 AN - 50535731; 1991-054003 JF - NUREG/CP (United States, Nuclear Regulatory Commission) Y1 - 1989 PY - 1989 DA - 1989 SP - 515 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - seismology KW - symposia KW - earthquakes KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50535731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Seventeenth+Water+reactor+safety+information+meeting%3B+Volume+2&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Seventeenth Water reactor safety information meeting; Volume 2 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1991-01-01 N1 - PubXState - DC N1 - SuppNotes - Individual papers within scope are cited separately N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - earthquakes; seismology; symposia ER - TY - JOUR T1 - The November 25, 1988 Saguenay earthquake in Quebec Province and its implications for seismic hazard AN - 50534742; 1991-054009 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Seeber, Leonardo AU - Tuttle, Martitia AU - Hough, Sue AU - Armbruster, John Y1 - 1989 PY - 1989 DA - 1989 SP - 393 EP - 406 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - seismology KW - Quebec KW - magnitude KW - liquefaction KW - observations KW - attenuation KW - rupture KW - Canada KW - seismicity KW - Saguenay earthquake 1988 KW - Eastern Canada KW - earthquakes KW - anisotropy KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50534742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=The+November+25%2C+1988+Saguenay+earthquake+in+Quebec+Province+and+its+implications+for+seismic+hazard&rft.au=Seeber%2C+Leonardo%3BTuttle%2C+Martitia%3BHough%2C+Sue%3BArmbruster%2C+John&rft.aulast=Seeber&rft.aufirst=Leonardo&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Seventeenth Water reactor safety information meeting; Volume 2 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1991-01-01 N1 - Number of references - 10 N1 - PubXState - DC N1 - Document feature - illus. incl. geol. sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - anisotropy; attenuation; Canada; earthquakes; Eastern Canada; liquefaction; magnitude; observations; Quebec; rupture; Saguenay earthquake 1988; seismicity; seismology ER - TY - JOUR T1 - Paleoseismic history of the Meers Fault, southwestern Oklahoma and implications for evaluations of earthquake hazards in the Central and Eastern United States AN - 50534711; 1991-054007 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Kelson, Keith I AU - Swan, F H Y1 - 1989 PY - 1989 DA - 1989 SP - 341 EP - 365 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - United States KW - history KW - Oklahoma KW - seismicity KW - structural geology KW - aulacogens KW - Meers Fault KW - distribution KW - faults KW - southwestern Oklahoma KW - 16:Structural geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50534711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Paleoseismic+history+of+the+Meers+Fault%2C+southwestern+Oklahoma+and+implications+for+evaluations+of+earthquake+hazards+in+the+Central+and+Eastern+United+States&rft.au=Kelson%2C+Keith+I%3BSwan%2C+F+H&rft.aulast=Kelson&rft.aufirst=Keith&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Seventeenth Water reactor safety information meeting; Volume 2 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1991-01-01 N1 - Number of references - 52 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables, geol. sketch maps N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aulacogens; distribution; faults; history; Meers Fault; Oklahoma; seismicity; southwestern Oklahoma; structural geology; United States ER - TY - JOUR T1 - Trace element analyses of clay minerals in anthracite coal from eastern Pennsylvania using the synchrotron X-ray fluorescence microprobe AN - 50408614; 1992-059040 JF - Abstracts with Programs - Geological Society of America AU - Daniels, Eric Joseph AU - Altaner, Stephen P AU - Sutton, Stephen R AU - Anonymous Y1 - 1989 PY - 1989 DA - 1989 SP - 163 PB - Geological Society of America (GSA), Boulder, CO VL - 21 IS - 6 SN - 0016-7592, 0016-7592 KW - United States KW - silicates KW - rectorite KW - organic residues KW - silica minerals KW - authigenic minerals KW - anthracite KW - temperature KW - synchrotron radiation KW - sedimentary rocks KW - coal KW - X-ray fluorescence spectra KW - sudoite KW - framework silicates KW - eastern Pennsylvania KW - spectra KW - mineral assemblages KW - trace elements KW - chlorite group KW - geochemistry KW - coalification KW - tosudite KW - kaolinite KW - clay minerals KW - quartz KW - sheet silicates KW - chalcophile elements KW - Pennsylvania KW - 06B:Petrology of coal KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50408614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Trace+element+analyses+of+clay+minerals+in+anthracite+coal+from+eastern+Pennsylvania+using+the+synchrotron+X-ray+fluorescence+microprobe&rft.au=Daniels%2C+Eric+Joseph%3BAltaner%2C+Stephen+P%3BSutton%2C+Stephen+R%3BAnonymous&rft.aulast=Daniels&rft.aufirst=Eric&rft.date=1989-01-01&rft.volume=21&rft.issue=6&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1989 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1992-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - anthracite; authigenic minerals; chalcophile elements; chlorite group; clay minerals; coal; coalification; eastern Pennsylvania; framework silicates; geochemistry; kaolinite; mineral assemblages; organic residues; Pennsylvania; quartz; rectorite; sedimentary rocks; sheet silicates; silica minerals; silicates; spectra; sudoite; synchrotron radiation; temperature; tosudite; trace elements; United States; X-ray fluorescence spectra ER - TY - JOUR T1 - In-situ trace-element microanalysis of inertinite and vitrinite macerals in New Mexico coals using synchrotron radiation AN - 50406051; 1992-059039 JF - Abstracts with Programs - Geological Society of America AU - Kolker, Allan AU - Sutton, S R AU - Jones, Keith W AU - Kuellmer, F J AU - Araya, Abraham AU - Anonymous Y1 - 1989 PY - 1989 DA - 1989 SP - 162 EP - 163 PB - Geological Society of America (GSA), Boulder, CO VL - 21 IS - 6 SN - 0016-7592, 0016-7592 KW - United States KW - organic residues KW - vitrinite KW - oxidation KW - inertinite KW - New Mexico KW - bituminous coal KW - York Canyon Mine KW - synchrotron radiation KW - sedimentary rocks KW - Raton Basin KW - Lee Ranch Mine KW - diagenesis KW - coal KW - macerals KW - San Juan Basin KW - trace elements KW - geochemistry KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50406051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=In-situ+trace-element+microanalysis+of+inertinite+and+vitrinite+macerals+in+New+Mexico+coals+using+synchrotron+radiation&rft.au=Kolker%2C+Allan%3BSutton%2C+S+R%3BJones%2C+Keith+W%3BKuellmer%2C+F+J%3BAraya%2C+Abraham%3BAnonymous&rft.aulast=Kolker&rft.aufirst=Allan&rft.date=1989-01-01&rft.volume=21&rft.issue=6&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1989 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1992-01-01 N1 - PubXState - CO N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - bituminous coal; coal; diagenesis; geochemistry; inertinite; Lee Ranch Mine; macerals; New Mexico; organic residues; oxidation; Raton Basin; San Juan Basin; sedimentary rocks; synchrotron radiation; trace elements; United States; vitrinite; York Canyon Mine ER - TY - JOUR T1 - Trace element microprobe analyses using charged particle reactions AN - 50405605; 1992-059087 JF - Abstracts with Programs - Geological Society of America AU - Sutton, Stephen R AU - Rivers, Mark L AU - Jones, Keith W AU - Anonymous Y1 - 1989 PY - 1989 DA - 1989 SP - 172 PB - Geological Society of America (GSA), Boulder, CO VL - 21 IS - 6 SN - 0016-7592, 0016-7592 KW - methods KW - partitioning KW - meteorites KW - chemical analysis KW - applications KW - trace-element analyses KW - sulfides KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50405605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Trace+element+microprobe+analyses+using+charged+particle+reactions&rft.au=Sutton%2C+Stephen+R%3BRivers%2C+Mark+L%3BJones%2C+Keith+W%3BAnonymous&rft.aulast=Sutton&rft.aufirst=Stephen&rft.date=1989-01-01&rft.volume=21&rft.issue=6&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 1989 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1992-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - applications; chemical analysis; meteorites; methods; partitioning; sulfides; trace-element analyses ER - TY - JOUR T1 - Structure determination from high resolution synchrotron X-ray powder diffraction data AN - 50207235; 1995-000382 JF - International Geological Congress, Abstracts--Congres Geologique Internationale, Resumes AU - Cox, D E AU - Anonymous Y1 - 1989 PY - 1989 DA - 1989 SP - 336 PB - [International Geological Congress], [location varies] VL - 28, vol. 1 KW - silicates KW - X-ray diffraction data KW - zeolite group KW - synchrotrons KW - framework silicates KW - crystal structure KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50207235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Geological+Congress%2C+Abstracts--Congres+Geologique+Internationale%2C+Resumes&rft.atitle=Structure+determination+from+high+resolution+synchrotron+X-ray+powder+diffraction+data&rft.au=Cox%2C+D+E%3BAnonymous&rft.aulast=Cox&rft.aufirst=D&rft.date=1989-01-01&rft.volume=28%2C+vol.+1&rft.issue=&rft.spage=336&rft.isbn=&rft.btitle=&rft.title=International+Geological+Congress%2C+Abstracts--Congres+Geologique+Internationale%2C+Resumes&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-eighth international geological congress N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - Number of references - 1 N1 - Last updated - 2012-06-07 N1 - CODEN - IGABBY N1 - SubjectsTermNotLitGenreText - crystal structure; framework silicates; silicates; synchrotrons; X-ray diffraction data; zeolite group ER - TY - JOUR T1 - A dynamic model for the P1 to I1 phase transition in anorthite, CaAl (sub 2) Si (sub ) O (sub 8) ; evidence from electron microscopy, X-ray and neutron diffraction, and a Landau theory AN - 50140284; 2009-092841 JF - International Geological Congress, Abstracts = Congres Geologique International, Resumes AU - Ghose, S AU - Tsukimura, K AU - van Tendeloo, G AU - Amelinckx, S AU - Hatch, D M AU - Weber, H P AU - McMullan, R K AU - Anonymous Y1 - 1989 PY - 1989 DA - 1989 SP - 1.549 EP - 1.550 PB - [International Geological Congress], [location varies] VL - 28, Vol. 1 KW - silicates KW - plagioclase KW - refinement KW - X-ray diffraction data KW - mechanism KW - phase transitions KW - electron microscopy data KW - crystal structure KW - indicators KW - order-disorder KW - anorthite KW - models KW - Landau theory KW - phase equilibria KW - neutron diffraction data KW - framework silicates KW - feldspar group KW - 17B:Geophysics of minerals and rocks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50140284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Geological+Congress%2C+Abstracts+%3D+Congres+Geologique+International%2C+Resumes&rft.atitle=A+dynamic+model+for+the+P1+to+I1+phase+transition+in+anorthite%2C+CaAl+%28sub+2%29+Si+%28sub+%29+O+%28sub+8%29+%3B+evidence+from+electron+microscopy%2C+X-ray+and+neutron+diffraction%2C+and+a+Landau+theory&rft.au=Ghose%2C+S%3BTsukimura%2C+K%3Bvan+Tendeloo%2C+G%3BAmelinckx%2C+S%3BHatch%2C+D+M%3BWeber%2C+H+P%3BMcMullan%2C+R+K%3BAnonymous&rft.aulast=Ghose&rft.aufirst=S&rft.date=1989-01-01&rft.volume=28%2C+Vol.+1&rft.issue=&rft.spage=1.549&rft.isbn=&rft.btitle=&rft.title=International+Geological+Congress%2C+Abstracts+%3D+Congres+Geologique+International%2C+Resumes&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Twenty-eighth international geological congress; abstracts N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - IGABBY N1 - SubjectsTermNotLitGenreText - anorthite; crystal structure; electron microscopy data; feldspar group; framework silicates; indicators; Landau theory; mechanism; models; neutron diffraction data; order-disorder; phase equilibria; phase transitions; plagioclase; refinement; silicates; X-ray diffraction data ER - TY - JOUR T1 - A Process for Solidifying Sodium Nitrate Waste in Polyethylene AN - 19123242; 9106130 AB - A laboratory-scale process has been developed for the solidification of nitrate salt wastes in polyethylene. The process uses a commercially available single-screw extruder which continuously discharges prescribed polyethylene-waste mixtures from the hoppers to the output die, where it is extruded into a container while still in the molten form. The molten mixture (about 110 to 120 C) conforms to the shape of the container and solidifies upon cooling. Proportional feeders maintain waste-to-binder ratio and homogeneity of the waste form. Present studies use dry wastes, although wet solid wastes can be processed using vented extruders of the type used for the bitumen solidification process. Tests were performed to determine leachability and mechanical stability. Emphasis is placed upon leaching of nitrates from the waste forms. Leach tests were performed according to American Nuclear Society (ANS) 16.1 as well as the EPA extraction procedure (EP). For polyethylene waste forms containing 30 to 40 weight percent sodium nitrate, ANS 16.1 leach indices range from 11 to 7.8, respectively. Compressive yield strengths range from 18 to 5 MPa (after 90 days' water immersion). The results of the EP indicate that the nitrate release levels for waste forms containing as much as 70 weight % sodium nitrate are not defined as characteristically hazardous waste. Differential scanning calorimetry (DSC) was used to confirm the compatibility of polyethylene and simulated salt wastes at elevated temperatures. Components of the polyethylene/sodium nitrate system, alone and in combination, were tested by DSC at temperatures to 400 C. At these temperatures, no chemical interactions were observed between polyethylene and nitrate waste compositions. (See also W91-06124) (Author's abstract) JF - IN: Environmental Aspects of Stabilization and Solidification of Hazardous and Radioactive Wastes. STP 1033. ASTM, Philadelphia, PA, 1989. p 53-62, 6 fig, 4 tab, 14 ref. AU - Heiser, J H AU - Franz, E-M AU - Colombo, P AD - Nuclear Waste Research Group, Fuel Cycle Analysis Division, Brookhaven National Laboratory, Associated University, Inc., Upton NY 11973 Y1 - 1989 PY - 1989 DA - 1989 KW - Water Resources Abstracts KW - Hazardous waste disposal KW - Polyethylene KW - Sodium nitrate KW - Waste disposal KW - Waste solidification KW - Waste stabilization KW - Calorimetry KW - Extrusion KW - Hazardous wastes KW - Leaching KW - Organic compounds KW - Waste containment KW - SW 3050:Ultimate disposal of wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19123242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=A+Process+for+Solidifying+Sodium+Nitrate+Waste+in+Polyethylene&rft.au=Heiser%2C+J+H%3BFranz%2C+E-M%3BColombo%2C+P&rft.aulast=Heiser&rft.aufirst=J&rft.date=1989-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Acid deposition: unravelling a regional phenomenon AN - 13766121; 198903205 AB - The geographical distributions of emissions and deposition of sulphur and nitrogen oxides are discussed. The scale of transport, the importance of atmospheric processes and regional scale physical simulation modelling are considered. The empirical determination of source receptor relations, linking emissions to deposition, is outlined. Implications for regulatory actions are discussed. There are 144 references. JF - Science AU - Schwartz, SE AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1989 PY - 1989 DA - 1989 SP - 753 EP - 763 VL - 243 IS - 4892 KW - Modelling (-general-) KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13766121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=Acid+deposition%3A+unravelling+a+regional+phenomenon&rft.au=Schwartz%2C+SE&rft.aulast=Schwartz&rft.aufirst=SE&rft.date=1989-01-01&rft.volume=243&rft.issue=4892&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Aerobic and anaerobic microbial dissolution of toxic metals from coal wastes: mechanism of action AN - 13760905; S199032479 AB - Two samples of coal-cleaning residue, one high in trace metals and relatively low in organic carbon (fines fraction) and the other low in trace metals and relatively high in organic carbon (filter cake) were used in a study of the extent and mechanism of the microbial dissolution of toxic metals by the native microflora in the residue in aerobic and anaerobic conditions. In aerobic conditions the dominant mechanism in the solubilization of metals was the bacterial oxidation of pyrite. In anaerobic conditions solubilization of metals was due mainly to the bacterial reduction of iron and manganese oxides and the release of trace metals coprecipitated with the oxides. There are 31 references. JF - Environmental Science & Technology AU - Francis, A J AU - Dodge, C J AU - Rose, A W AU - Ramirez, A J AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1989 PY - 1989 DA - 1989 SP - 435 EP - 441 VL - 23 IS - 4 SN - 0013-936X, 0013-936X KW - Aqualine Abstracts KW - AQ 00007:Industrial Effluents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13760905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Aerobic+and+anaerobic+microbial+dissolution+of+toxic+metals+from+coal+wastes%3A+mechanism+of+action&rft.au=Francis%2C+A+J%3BDodge%2C+C+J%3BRose%2C+A+W%3BRamirez%2C+A+J&rft.aulast=Francis&rft.aufirst=A&rft.date=1989-01-01&rft.volume=23&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - The cytogenetic evaluation of in vivo genotoxic and cytotoxic activity using rodent somatic cells. AN - 78675676; 3228715 AB - With the growing realization that in vitro short-term tests for genotoxicity can never fully mimic in vivo conditions, the evaluation of genotoxic damage in somatic cells of rodents has played an increasingly important role in assessing the carcinogenic potential of suspect compounds. Among the various genotoxic endpoints assessed in in vivo somatic cell assays, cytogenetic endpoints (e.g., chromosomal aberrations, micronuclei, sister chromatid exchanges) continue to be used most frequently. The purpose of this paper is to demonstrate the utility of evaluating different cytogenetic endpoints in the same animal, using as examples studies to evaluate the in vivo genotoxic potential of benzene, of methylisocyanate, and of butadiene, chloroprene and isoprene. JF - Cell biology and toxicology AU - Tice, R R AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1988/12// PY - 1988 DA - December 1988 SP - 475 EP - 486 VL - 4 IS - 4 SN - 0742-2091, 0742-2091 KW - Butadienes KW - 0 KW - Cyanates KW - Hemiterpenes KW - Isocyanates KW - Mutagens KW - Pentanes KW - isoprene KW - 0A62964IBU KW - Chloroprene KW - 126-99-8 KW - methyl isocyanate KW - C588JJ4BV9 KW - Benzene KW - J64922108F KW - Index Medicus KW - Cyanates -- toxicity KW - Animals KW - Mutagenicity Tests KW - Butadienes -- toxicity KW - Carcinogenicity Tests KW - Benzene -- toxicity KW - Mice KW - Chloroprene -- toxicity KW - Male KW - Female KW - Chromosome Aberrations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78675676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+biology+and+toxicology&rft.atitle=The+cytogenetic+evaluation+of+in+vivo+genotoxic+and+cytotoxic+activity+using+rodent+somatic+cells.&rft.au=Tice%2C+R+R&rft.aulast=Tice&rft.aufirst=R&rft.date=1988-12-01&rft.volume=4&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Cell+biology+and+toxicology&rft.issn=07422091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-04-17 N1 - Date created - 1989-04-17 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Pathophysiology of cyanoginosin-LR: in vivo and in vitro studies. AN - 78550227; 3194914 AB - Cyanoginosin-LR, one of the group of virulent cyclic heptapeptide toxins (cyanoginosins) isolated from some strains of the cyanobacterium, Microcystis aeruginosa, kills mice within 1-2 hr after iv or ip injection. Although the liver is a target organ of the toxin, the rapidity of lethality is incompatible with metabolic death from failure of hepatocellular function. However, disintegration of sinusoidal endothelium causes massive intrahepatic hemorrhage. The loss of the structural integrity of hepatic sinusoids provides a previously undescribed mechanism for embolization of disintegrating cells from the liver to the lung. No injury to either cultured bovine pulmonary artery endothelial cells or mouse peritoneal macrophages was observed following prolonged incubation with high concentrations of the toxin, and there was no increase in vascular permeability to 125I-labeled albumin detected before intrahepatic hemorrhage. However, plasma fibronectin increased transiently after toxin injection. Acute, severe thrombocytopenia, a characteristic of cyanoginosin-LR toxicity, remains unexplained since platelets did not concentrate in the lungs, liver, or spleen. There are similarities between the effects of cyanoginosin-LR and of the lipopolysaccharide endotoxins, such as elevations of plasma levels of thromboxane B2 and 6-keto-prostaglandin F1 alpha. JF - Toxicology and applied pharmacology AU - Adams, W H AU - Stone, J P AU - Sylvester, B AU - Stoner, R D AU - Slatkin, D N AU - Tempel, N R AU - Siegelman, H W AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1988/11// PY - 1988 DA - November 1988 SP - 248 EP - 257 VL - 96 IS - 2 SN - 0041-008X, 0041-008X KW - Fibronectins KW - 0 KW - Microcystins KW - Peptides, Cyclic KW - cyanoginosin LR KW - EQ8332842Y KW - Index Medicus KW - Animals KW - Lung -- drug effects KW - Thrombocytopenia -- chemically induced KW - Fibronectins -- metabolism KW - Microscopy, Electron KW - Mice KW - Liver -- pathology KW - Liver -- drug effects KW - Peptides, Cyclic -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78550227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Pathophysiology+of+cyanoginosin-LR%3A+in+vivo+and+in+vitro+studies.&rft.au=Adams%2C+W+H%3BStone%2C+J+P%3BSylvester%2C+B%3BStoner%2C+R+D%3BSlatkin%2C+D+N%3BTempel%2C+N+R%3BSiegelman%2C+H+W&rft.aulast=Adams&rft.aufirst=W&rft.date=1988-11-01&rft.volume=96&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1989-01-09 N1 - Date created - 1989-01-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. AN - 78421621; 3047567 AB - The estimation of the magnitude of a dose of ionizing radiation to which an individual has been exposed (or of the plausibility of an alleged exposure) from chromosomal aberration frequencies determined in peripheral blood lymphocyte cultures is a well-established methodology, having first been employed over 25 years ago. The cytogenetics working group has reviewed the accumulated data and the possible applicability of the technique to the determination of radiation doses to which American veterans might have been exposed as participants in nuclear weapons tests in the continental U.S.A. or the Pacific Atolls during the late 1940s and 1950s or as members of the Occupation Forces entering Hiroshima or Nagasaki shortly after the nuclear detonations there. The working group believes that with prompt peripheral blood sampling, external doses to individuals of the order of about 10 rad (or less if the exposure was to high-LET radiation) can accurately be detected and measured. It also believes that exposures of populations to doses of the order of maximum permissible occupational exposures can also be detected (but only in populations; not in an individual). Large exposures of populations can also be detected even several decades after their exposure, but only in the case of populations, and of large doses (of the order of 100 to several hundred rad). The working group does not believe that cytogenetic measurements can detect internal doses from fallout radionuclides in individuals unless these are very large. The working group has approached the problem of detection of small doses (less than or equal to 10 or so rad) sampled decades after the exposure of individuals by using a Bayesian statistical approach. Only a preliminary evaluation of this approach was possible, but it is clear that it could provide a formal statement of the likelihood that any given observation of a particular number of chromosomal aberrations in a sample of any particular number of lymphocytes actually indicates an exposure to any given dose of radiation. It is also clear that aberration frequencies (and consequently doses) would have to be quite high before much confidence could be given to either exposure or dose estimation by this method, given the approximately 3 decades of elapsed time between the exposures and any future blood sampling.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Mutation research AU - Bender, M A AU - Awa, A A AU - Brooks, A L AU - Evans, H J AU - Groer, P G AU - Littlefield, L G AU - Pereira, C AU - Preston, R J AU - Wachholz, B W AD - Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 103 EP - 159 VL - 196 IS - 2 SN - 0027-5107, 0027-5107 KW - Index Medicus KW - Humans KW - Abnormalities, Radiation-Induced -- diagnosis KW - Environmental Exposure KW - Chromosome Aberrations KW - Abnormalities, Radiation-Induced -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78421621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Current+status+of+cytogenetic+procedures+to+detect+and+quantify+previous+exposures+to+radiation.&rft.au=Bender%2C+M+A%3BAwa%2C+A+A%3BBrooks%2C+A+L%3BEvans%2C+H+J%3BGroer%2C+P+G%3BLittlefield%2C+L+G%3BPereira%2C+C%3BPreston%2C+R+J%3BWachholz%2C+B+W&rft.aulast=Bender&rft.aufirst=M&rft.date=1988-09-01&rft.volume=196&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-24 N1 - Date created - 1988-10-24 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Chromosomal aberrations and sister-chromatid exchanges in lymphocytes from coke oven workers. AN - 78391112; 3412368 AB - To test whether coke oven workers, an occupational group known to be at increased cancer risk, manifest increased peripheral blood chromosomal aberration frequencies, we obtained samples from a group of 30 steelworker volunteers, who had worked several years at coke oven jobs. Exposure estimates were made using measurements of work place atmospheric coal tar pitch volatiles and work histories. No statistically significant positive regression of chromosomal aberrations on exposure estimates was found. The data from the coke oven workers were also compared with the obtained concurrently and employing precisely the same laboratory protocol from a group of male Brookhaven National Laboratory employees. The coke oven workers as a group were found to have statistically significantly elevated frequencies of chromatid aberrations and of sister-chromatid exchanges. JF - Mutation research AU - Bender, M A AU - Leonard, R C AU - White, O AU - Costantino, J P AU - Redmond, C K AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 11 EP - 16 VL - 206 IS - 1 SN - 0027-5107, 0027-5107 KW - Coke KW - 0 KW - Index Medicus KW - Aneuploidy KW - Humans KW - Lymphocytes KW - Male KW - Occupational Diseases -- genetics KW - Sister Chromatid Exchange KW - Chromosome Aberrations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78391112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Chromosomal+aberrations+and+sister-chromatid+exchanges+in+lymphocytes+from+coke+oven+workers.&rft.au=Bender%2C+M+A%3BLeonard%2C+R+C%3BWhite%2C+O%3BCostantino%2C+J+P%3BRedmond%2C+C+K&rft.aulast=Bender&rft.aufirst=M&rft.date=1988-09-01&rft.volume=206&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-07 N1 - Date created - 1988-10-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Characterization of the rec-1 gene of Haemophilus influenzae and behavior of the gene in Escherichia coli. AN - 78389046; 3045079 AB - The rec-1 gene of Haemophilus influenzae was cloned into a shuttle vector that replicates in Escherichia coli as well as in H. influenzae. The plasmid, called pRec1, complemented the defects of a rec-1 mutant in repair of UV damage, transformation, and ability of prophage to be induced by UV radiation. Although UV resistance and recombination were caused by pRec1 in E. coli recA mutants, UV induction of lambda and UV mutagenesis were not. We suggest that the ability of the H. influenzae Rec-1 protein to cause cleavage of repressors but not the recombinase function differs from that of the E. coli RecA protein. JF - Journal of bacteriology AU - Setlow, J K AU - Spikes, D AU - Griffin, K AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 3876 EP - 3881 VL - 170 IS - 9 SN - 0021-9193, 0021-9193 KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - Index Medicus KW - Ultraviolet Rays KW - Genes, Bacterial KW - DNA Repair KW - Genetic Vectors KW - Recombination, Genetic KW - Dose-Response Relationship, Radiation KW - Virus Activation KW - Plasmids KW - Mutation KW - Cloning, Molecular KW - Haemophilus influenzae -- radiation effects KW - Bacterial Proteins -- genetics KW - Haemophilus influenzae -- genetics KW - Escherichia coli -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78389046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Characterization+of+the+rec-1+gene+of+Haemophilus+influenzae+and+behavior+of+the+gene+in+Escherichia+coli.&rft.au=Setlow%2C+J+K%3BSpikes%2C+D%3BGriffin%2C+K&rft.aulast=Setlow&rft.aufirst=J&rft.date=1988-09-01&rft.volume=170&rft.issue=9&rft.spage=3876&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-06 N1 - Date created - 1988-10-06 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: J Bacteriol. 1969 Oct;100(1):231-9 [4898990] Z Vererbungsl. 1963 Dec 30;94:336-48 [14123302] J Mol Biol. 1972 Feb 14;63(3):349-62 [4536898] J Bacteriol. 1972 Jun;110(3):930-4 [4537422] J Mol Biol. 1972 Jul 21;68(2):361-78 [4560756] J Mol Biol. 1972 Jul 21;68(2):379-81 [4538404] J Bacteriol. 1973 Jul;115(1):153-61 [4541535] Annu Rev Genet. 1973;7:67-86 [4205905] J Bacteriol. 1974 Sep;119(3):705-17 [4546806] J Bacteriol. 1975 Oct;124(1):176-81 [1080760] J Bacteriol. 1976 Feb;125(2):643-54 [173712] J Bacteriol. 1976 Jul;127(1):327-33 [1084339] Radiat Res. 1966;:Suppl 6:156+ [5334390] J Bacteriol. 1968 Feb;95(2):546-58 [5300300] J Bacteriol. 1968 Jul;96(1):280-2 [5302006] Annu Rev Biochem. 1968;37:175-200 [4875714] J Bacteriol. 1968 Nov;96(5):1718-24 [5303721] Mutat Res. 1969 Jul-Aug;8(1):9-14 [4894425] Mutat Res. 1977 Aug;44(2):183-96 [302410] Proc Natl Acad Sci U S A. 1978 Oct;75(10):4714-8 [368796] J Bacteriol. 1979 Feb;137(2):830-8 [370103] Mol Gen Genet. 1979 Apr 17;172(1):17-24 [377021] Proc Natl Acad Sci U S A. 1980 Jan;77(1):313-7 [6244554] Proc Natl Acad Sci U S A. 1980 May;77(5):2611-5 [6930655] J Bacteriol. 1981 Dec;148(3):804-11 [6975774] J Bacteriol. 1981 Dec;148(3):812-6 [6975775] J Bacteriol. 1982 Sep;151(3):1605-7 [6286603] Nature. 1982 Nov 18;300(5889):278-81 [6755263] J Bacteriol. 1983 Jul;155(1):311-6 [6305915] Proc Natl Acad Sci U S A. 1984 Mar;81(5):1375-9 [6231641] J Bacteriol. 1984 Oct;160(1):153-60 [6090408] J Bacteriol. 1985 Jan;161(1):141-6 [3871435] J Biol Chem. 1985 Mar 25;260(6):3305-13 [3156134] J Bacteriol. 1985 Aug;163(2):568-72 [2991195] Proc Natl Acad Sci U S A. 1985 Nov;82(22):7753-6 [3877933] J Bacteriol. 1986 Jan;165(1):308-11 [3484477] J Bacteriol. 1986 Oct;168(1):458-9 [3489710] J Bacteriol. 1986 Dec;168(3):1159-64 [2946663] J Bacteriol. 1987 Jun;169(6):2739-47 [3108239] J Bacteriol. 1987 Jun;169(6):2906-10 [3584077] Proc Natl Acad Sci U S A. 1987 Jun;84(12):3987-91 [3108885] Gene. 1987;58(2-3):265-71 [3322946] J Bacteriol. 1988 Apr;170(4):1637-50 [2450868] J Biol Chem. 1956 Jan;218(1):97-106 [13278318] J Mol Biol. 1970 Oct 14;53(1):159-62 [4922220] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Low-level radioactive waste source term model development and testing; topical report AN - 51138157; 2005-008732 JF - NUREG/CR (United States. Nuclear Regulatory Commission) AU - Sullivan, T M AU - Kempf, C R AU - Suen, C J AU - Mughabghab, S M Y1 - 1988/09// PY - 1988 DA - September 1988 SP - 198 PB - U. S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, Washington, DC SN - 0278-1670, 0278-1670 KW - FEMWATER KW - computer programs KW - laboratory studies KW - experimental studies KW - movement KW - data processing KW - pollution KW - low-level waste KW - radioactive waste KW - ground water KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51138157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Sullivan%2C+T+M%3BKempf%2C+C+R%3BSuen%2C+C+J%3BMughabghab%2C+S+M&rft.aulast=Sullivan&rft.aufirst=T&rft.date=1988-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Low-level+radioactive+waste+source+term+model+development+and+testing%3B+topical+report&rft.title=Low-level+radioactive+waste+source+term+model+development+and+testing%3B+topical+report&rft.issn=02781670&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 79 N1 - PubXState - DC N1 - Document feature - illus. incl. 13 tables N1 - SuppNotes - Includes 6 appendices N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - computer programs; data processing; experimental studies; FEMWATER; ground water; laboratory studies; low-level waste; movement; pollution; radioactive waste ER - TY - JOUR T1 - The impact of the probability of causation on the radiation protection program. AN - 78397275; 3410706 AB - Although the probability of causation approach is the only scientific basis on which a given cancer can be judged to be causally related to a given exposure, the impact of this concept on the radiation safety program could be counter-productive. As health physicists, the practices and the concepts we employ have been developed to protect the worker. Effective dose equivalent and committed dose equivalent are protective concepts but useless for probability of causation analysis. Perhaps extensive records will be the only way that good radiation protection and probability of causation analysis can coexist. JF - Health physics AU - Meinhold, C B AD - Radiological Sciences Division, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 375 EP - 377 VL - 55 IS - 2 SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Humans KW - Neoplasms, Radiation-Induced KW - Radiation Protection KW - Jurisprudence KW - Radiation Monitoring UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78397275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=The+impact+of+the+probability+of+causation+on+the+radiation+protection+program.&rft.au=Meinhold%2C+C+B&rft.aulast=Meinhold&rft.aufirst=C&rft.date=1988-08-01&rft.volume=55&rft.issue=2&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-10-07 N1 - Date created - 1988-10-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - The effect of exposure regimen and duration on benzene-induced bone-marrow damage in mice. I. Sex comparison in DBA/2 mice. AN - 78353670; 3405235 AB - In the mouse, the concurrent evaluation of micronuclei frequencies in peripheral blood polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) permits an assessment of both recently-induced and chronically-accumulated bone-marrow damage. This assay system was used to evaluate on a weekly basis the effect of exposure duration (1-13 weeks, 6 h per day) and exposure regimen (Regimen 1:5 exposure days per week; Regimen 2:3 exposure days per week) on the ability of 300 ppm benzene to induce genotoxic damage in the bone marrow of male and female DBA/2 mice. In addition, an analysis of the percentage of PCE in peripheral blood was used to evaluate benzene-induced alterations in the rate of erythropoiesis. Exposure to benzene induced a marked increase in the frequency of micronucleated PCE (MN-PCE), an effect which was considerably greater in male mice than in female mice. In both sexes, the induction of MN-PCE was independent of exposure regiment and of exposure duration. Exposure to benzene also resulted in an exposure duration-dependent increase in the frequency of MN-NCE. The frequency of MN-NCE increased more slowly in female than in male mice and, within each sex, more slowly in Regimen 2 animals. Apparent steady-state conditions for MN-NCE frequencies were attained by about the fifth week of exposure in female mice exposed by either regimen and in male mice exposed by Regimen 2. Steady-state conditions for MN-NCE frequencies in male mice exposed to benzene by Regimen 1 did not occur during the duration of the study. An analysis of %PCE data revealed an initial severe depression in the rate of erythropoiesis in both sexes, with the return in the production of PCE to control levels being dependent on both sex and exposure regimen. Suppression of PCE production occurred throughout the course of the study in Regimen 2 males, while the percentage of PCE returned to control levels sporadically after 5 weeks in Regimen 1 males and within 5 weeks in females, regardless of regimen. Thus, while the sex-dependent induction of genotoxic damage by multiple exposures to benzene over a 13-week period was independent of exposure regimen and duration, the induction of cytotoxic damage was both sex- and regimen-dependent. The most severe depression of erythropoiesis occurred in male DBA/2 mice exposed to benzene by the more intermittent regimen (i.e., 3 days/week versus 5 days/week).(ABSTRACT TRUNCATED AT 400 WORDS) JF - Mutation research AU - Luke, C A AU - Tice, R R AU - Drew, R T AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 251 EP - 271 VL - 203 IS - 4 SN - 0027-5107, 0027-5107 KW - Benzene KW - J64922108F KW - Index Medicus KW - Erythropoiesis -- drug effects KW - Erythrocytes -- drug effects KW - Animals KW - Cell Nucleus -- pathology KW - Erythrocyte Count -- drug effects KW - Kinetics KW - Mice KW - Cell Nucleus -- drug effects KW - Time Factors KW - Male KW - Female KW - Erythrocytes -- pathology KW - Mice, Inbred DBA KW - Bone Marrow -- pathology KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Environmental Exposure KW - Benzene -- toxicity KW - Bone Marrow -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78353670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+effect+of+exposure+regimen+and+duration+on+benzene-induced+bone-marrow+damage+in+mice.+I.+Sex+comparison+in+DBA%2F2+mice.&rft.au=Luke%2C+C+A%3BTice%2C+R+R%3BDrew%2C+R+T&rft.aulast=Luke&rft.aufirst=C&rft.date=1988-08-01&rft.volume=203&rft.issue=4&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-20 N1 - Date created - 1988-09-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - The effect of exposure regimen and duration on benzene-induced bone marrow damage in mice. II. Strain comparisons involving B6C3F1, C57B1/6 and DBA/2 male mice. AN - 78353347; 3405236 AB - In a companion paper (Luke et al., 1988), the effect of exposure duration and regimen on benzene induced-bone marrow damage was evaluated in male and female DBA/2 mice using the peripheral blood micronucleus assay. To assess the general applicability of the findings obtained for DBA/2 mice to other strains, similar studies were conducted using B6C3F1 and C57B1/6 male mice. An analysis of peripheral blood smears taken weekly from these mice exposed to 300 ppm benzene for 13 weeks (6 h per day) for either 5 days per week (Regimen 1) or for 3 days per week (Regimen 2) revealed: (i) a highly significant increase in the frequency of micronucleated polychromatic erythrocytes (MN-PCE), the magnitude of which was strain specific (DBA/2 greater than C57B1/6 = B6C3F1), but independent of exposure regimen and, except for Regimen 2 B6C3F1 mice, of exposure duration. In male B6C3F1 mice, MN-PCE frequencies increased slightly with increasing exposure duration; (ii) a strain- (C57B1/6 = B6C3F1 greater than DBA/2) and regimen- (Regimen 1 greater than Regimen 2) dependent increase across time in the frequency of micronucleated normochromatic erythrocytes (MN-NCE). Apparent steady-state conditions for MN-NCE frequencies were attained by about 5 weeks of exposure in male mice of all three strains exposed to benzene by Regimen 2. Steady-state conditions for MN-NCE frequencies in male mice exposed to benzene by Regimen 1 did not occur during the duration of the study, with strain-dependent differences in the kinetics of MN-NCE accumulation being present; and (iii) in all 3 strains, an initial severe depression in the rate of erythropoiesis, the return of which to normal levels was both strain- (C57B1/6 = B6C3F1 greater than DBA/2) and regimen- (Regimen 1 greater than Regimen 2) dependent. These data indicate that the induction of genotoxic and cytotoxic damage in the bone marrow of male mice exposed to benzene for 13 weeks can be highly dependent on strain, exposure regimen and exposure duration but that under no circumstance did the level of genotoxic damage induced by benzene decrease under multiple exposure conditions. JF - Mutation research AU - Luke, C A AU - Tice, R R AU - Drew, R T AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/08// PY - 1988 DA - August 1988 SP - 273 EP - 295 VL - 203 IS - 4 SN - 0027-5107, 0027-5107 KW - Benzene KW - J64922108F KW - Index Medicus KW - Erythropoiesis -- drug effects KW - Erythrocytes -- drug effects KW - Animals KW - Cell Nucleus -- pathology KW - Erythrocyte Count -- drug effects KW - Mice, Inbred C57BL KW - Mice KW - Cell Nucleus -- drug effects KW - Time Factors KW - Male KW - Erythrocytes -- pathology KW - Mice, Inbred DBA KW - Bone Marrow -- pathology KW - Dose-Response Relationship, Drug KW - Environmental Exposure KW - Benzene -- toxicity KW - Species Specificity KW - Bone Marrow -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78353347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+effect+of+exposure+regimen+and+duration+on+benzene-induced+bone+marrow+damage+in+mice.+II.+Strain+comparisons+involving+B6C3F1%2C+C57B1%2F6+and+DBA%2F2+male+mice.&rft.au=Luke%2C+C+A%3BTice%2C+R+R%3BDrew%2C+R+T&rft.aulast=Luke&rft.aufirst=C&rft.date=1988-08-01&rft.volume=203&rft.issue=4&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-20 N1 - Date created - 1988-09-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Cellular Ca2+ homeostasis and Ca2+-mediated cell processes as critical targets for toxicant action: conceptual and methodological pitfalls. AN - 78329840; 3041648 AB - Because of the central role of the calcium messenger system in diverse functions of tissues, organs, and cells, Ca2+ homeostasis and function may prove to be critical cellular and molecular targets for a diverse range of toxicants. Experimental proof of these targets as a specific site of toxicant action is challenging and technically difficult as a result of the complexity of Ca2+ homeostatic and Ca2+-mediated processes. However, as the investigation of normal physiological control of Ca2+ and function will continue to be an active and productive area of basic research for several years to come, it is anticipated that these insights will be increasingly applied to the understanding of the mechanisms of action of toxic agents. JF - Toxicology and applied pharmacology AU - Pounds, J G AU - Rosen, J F AD - Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1988/07// PY - 1988 DA - July 1988 SP - 331 EP - 341 VL - 94 IS - 3 SN - 0041-008X, 0041-008X KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Humans KW - Biological Transport KW - Calcium -- metabolism KW - Homeostasis -- drug effects KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78329840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Cellular+Ca2%2B+homeostasis+and+Ca2%2B-mediated+cell+processes+as+critical+targets+for+toxicant+action%3A+conceptual+and+methodological+pitfalls.&rft.au=Pounds%2C+J+G%3BRosen%2C+J+F&rft.aulast=Pounds&rft.aufirst=J&rft.date=1988-07-01&rft.volume=94&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-09-02 N1 - Date created - 1988-09-02 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Central nervous system radiation syndrome in mice from preferential 10B(n, alpha)7Li irradiation of brain vasculature. AN - 78259741; 3375251 AB - Ionizing radiations were directed at the heads of anesthetized mice in doses that evoked the acute central nervous system (CNS) radiation syndrome. Irradiations were done using either a predominantly thermal neutron field at a nuclear reactor after intraperitoneal injection of 10B-enriched boric acid or 250-kilovolt-peak x-rays with and without previous intraperitoneal injection of equivalent unenriched boric acid. Since 10B concentrations were approximately equal to 3-fold higher in blood than in cerebral parenchyma during the reactor irradiations, more radiation from alpha and 7Li particles was absorbed by brain endothelial cells than by brain parenchymal cells. Comparison of the LD50 dose for CNS radiation lethality from the reactor experiments with the LD50 dose from the x-ray experiments gives results compatible with morphologic evidence that endothelial cell damage is a major determinant of acute lethality from the CNS radiation syndrome. It was also observed that boric acid is a low linear energy transfer radiation-enhancement agent in vivo. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Slatkin, D N AU - Stoner, R D AU - Rosander, K M AU - Kalef-Ezra, J A AU - Laissue, J A AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 4020 EP - 4024 VL - 85 IS - 11 SN - 0027-8424, 0027-8424 KW - Lithium KW - 9FN79X2M3F KW - Boron KW - N9E3X5056Q KW - Index Medicus KW - Space life sciences KW - Animals KW - X-Rays KW - Mice KW - Dose-Response Relationship, Radiation KW - Radiation, Ionizing KW - Endothelium, Vascular -- radiation effects KW - Radiation Injuries, Experimental -- pathology KW - Brain -- radiation effects KW - Radiation Injuries, Experimental -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78259741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Central+nervous+system+radiation+syndrome+in+mice+from+preferential+10B%28n%2C+alpha%297Li+irradiation+of+brain+vasculature.&rft.au=Slatkin%2C+D+N%3BStoner%2C+R+D%3BRosander%2C+K+M%3BKalef-Ezra%2C+J+A%3BLaissue%2C+J+A&rft.aulast=Slatkin&rft.aufirst=D&rft.date=1988-06-01&rft.volume=85&rft.issue=11&rft.spage=4020&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-08 N1 - Date created - 1988-07-08 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Radiat Res. 1970 Sep;43(3):534-53 [5460394] Radiat Res. 1975 Feb;61(2):304-15 [803317] Phys Med Biol. 1976 Jan;21(1):134-8 [1257291] Radiat Res. 1982 Jul;91(1):77-94 [7100396] Am Heart J. 1982 Nov;104(5 Pt 1):1076-85 [7137000] Proc Natl Acad Sci U S A. 1983 Jun;80(11):3480-4 [6344086] Radiology. 1956 Nov;67(5):650-64 [13370877] Med Phys. 1986 Jan-Feb;13(1):50-6 [3951409] Biochem Pharmacol. 1986 May 15;35(10):1771-6 [3707608] Fed Proc. 1986 Jun;45(7):2047-9 [3519288] Sci Am. 1986 Sep;255(3):74-83 [3749857] Am J Physiol. 1951 Feb;164(2):546-56 [14810963] Radiat Res. 1984 May;98(2):307-16 [6729040] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Human cell transformation in the study of sunlight-induced cancers in the skin of man. AN - 78238807; 3374510 AB - Human cell transformation provides a powerful approach to understanding--at the cellular and molecular levels--induction of cancers in the skin of man. A principal approach to this problem is the direct transformation of human skin cells by exposure to ultraviolet and/or near-UV radiation. The frequency of human cells transformed to anchorage independence increases with radiation exposure; the relative transforming efficiencies of different wavelengths implies that direct absorption by nucleic acids is a primary initial event. Partial reversal of potential transforming lesions by photoreactivation suggests that pyrimidine dimers, as well as other lesions, are important in UV transformation of human cells. Human cells can also be transformed by transfection with cloned oncogenes, or with DNAs from tumors or tumor cell lines. Cells treated by the transfection procedure (but without DNA) or cells transfected with DNAs from normal mammalian cells or tissues show only background levels of transformation. Human cells can be transformed to anchorage-independent growth by DNAs ineffective in transformation of NIH 3T3 cells (including most human skin cancers), permitting the analysis of oncogenic molecular changes even in tumor DNAs difficult or impossible to analyze in rodent cell systems. JF - Mutation research AU - Sutherland, B M AU - Freeman, A G AU - Bennett, P V AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/06// PY - 1988 DA - June 1988 SP - 425 EP - 436 VL - 199 IS - 2 SN - 0027-5107, 0027-5107 KW - Culture Media KW - 0 KW - Index Medicus KW - Cells, Cultured KW - Humans KW - Cell Division -- radiation effects KW - Ultraviolet Rays KW - Neoplasms, Radiation-Induced -- pathology KW - Sunlight -- adverse effects KW - Skin Neoplasms -- etiology KW - Skin Neoplasms -- pathology KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78238807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Human+cell+transformation+in+the+study+of+sunlight-induced+cancers+in+the+skin+of+man.&rft.au=Sutherland%2C+B+M%3BFreeman%2C+A+G%3BBennett%2C+P+V&rft.aulast=Sutherland&rft.aufirst=B&rft.date=1988-06-01&rft.volume=199&rft.issue=2&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-05 N1 - Date created - 1988-07-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Normal G2 chromosomal radiosensitivity and cell survival in the cancer family syndrome. AN - 78162362; 3356018 AB - Recent reports have suggested that elevated chromosomal aberration yields following X-irradiation of skin fibroblasts in the G2 phase of the cell cycle are characteristic of affected members of cancer-prone families. These studies propose that this phenomenon is a consequence of impaired DNA repair and might be a useful predictor of genetic susceptibility to cancer. We have tested G2 chromosomal X-ray sensitivity in skin fibroblasts and peripheral blood lymphocytes from members of a kindred with the cancer family syndrome, a disorder in which susceptibility to colon cancer and other epithelial cancers is inherited in an autosomal dominant pattern. Further, using a cell survival assay, we tested cancer family syndrome skin fibroblasts for sensitivity to four classes of mutagens, including X-rays. In the assays used, skin fibroblasts and lymphocytes from both affected and unaffected family members exhibited responses indistinguishable from normal controls. Karyotypic analysis of lymphocytes and fibroblasts revealed no consistent constitutional cytogenetic abnormality. Thus, affected patients with the cancer family syndrome do not have increased sensitivity to irradiation and chemical mutagens and lack a germ-line chromosomal defect. JF - Cancer research AU - Bender, M A AU - Viola, M V AU - Fiore, J AU - Thompson, M H AU - Leonard, R C AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1988/05/01/ PY - 1988 DA - 1988 May 01 SP - 2579 EP - 2584 VL - 48 IS - 9 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - DNA Repair KW - Syndrome KW - Humans KW - Chromosome Aberrations KW - Fibroblasts -- radiation effects KW - Lymphocytes -- ultrastructure KW - Cell Survival KW - Colonic Neoplasms -- genetics KW - Neoplastic Syndromes, Hereditary -- pathology KW - Radiation Tolerance KW - Interphase KW - Colonic Neoplasms -- pathology KW - Chromosomes -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78162362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Normal+G2+chromosomal+radiosensitivity+and+cell+survival+in+the+cancer+family+syndrome.&rft.au=Bender%2C+M+A%3BViola%2C+M+V%3BFiore%2C+J%3BThompson%2C+M+H%3BLeonard%2C+R+C&rft.aulast=Bender&rft.aufirst=M&rft.date=1988-05-01&rft.volume=48&rft.issue=9&rft.spage=2579&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-05-18 N1 - Date created - 1988-05-18 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: Cancer Res. 1989 Aug 15;49(16):4671-3 [2635879] N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Heterogeneous ventilation and perfusion: a sensitive indicator of lung impairment in nonsmoking coal miners. AN - 78269655; 3384076 AB - Twenty life-long nonsmoking West Virginia coal-miners participated in a study to amplify the role of focal irregularities on regional ventilation (V) and perfusion (Q) and to develop an improved method for the early detection of coal-workers' pneumoconiosis. Their mean age was 59.3 yr and they averaged 35.2 years' exposure to coal dust. Conventional pulmonary function tests were supplemented by measurement of V, Q and lung volume (V), using radioactive Kr-81m, Tc-99m MAA and Xe-127, respectively, to determine regional abnormalities in lung function. A computer analysis of the regional distributions of V/V, Q/V and V/Q was performed, and their topographical distributions and indices of heterogeneity (HI) computed. V/V and Q/V were significantly reduced in the lower third, and increased in the upper two-thirds of the miners' lungs; V/Q was reduced in the upper half. The miners' V/V and Q/V were more heterogeneous (p less than 0.001) than that of eleven age-matched controls, with mean ventilation HI values of 0.190 +/- 0.027 and 0.133 +/- 0.011, respectively, and mean perfusion HI values of 0.206 +/- 0.022 and 0.164 +/- 0.041, respectively. P(A-a)O2 correlated positively (r = 0.72; p less than 0.001) with ventilation HI. Gas exchange was the most significant functional measurement, being abnormal in 19/20 subjects. In contrast, conventional spirometric measurements were within the predicted normal limits in all but four miners. JF - The European respiratory journal AU - Susskind, H AU - Acevedo, J C AU - Iwai, J AU - Rasmussen, D L AU - Heydinger, D K AU - Pate, H R AU - Harold, W H AU - Brill, A B AD - Medical Research Center, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 232 EP - 241 VL - 1 IS - 3 SN - 0903-1936, 0903-1936 KW - Index Medicus KW - Smoking -- physiopathology KW - Respiratory Function Tests KW - Spirometry KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Radionuclide Imaging KW - Pneumoconiosis -- diagnostic imaging KW - Ventilation-Perfusion Ratio KW - Coal Mining KW - Pneumoconiosis -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78269655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+respiratory+journal&rft.atitle=Heterogeneous+ventilation+and+perfusion%3A+a+sensitive+indicator+of+lung+impairment+in+nonsmoking+coal+miners.&rft.au=Susskind%2C+H%3BAcevedo%2C+J+C%3BIwai%2C+J%3BRasmussen%2C+D+L%3BHeydinger%2C+D+K%3BPate%2C+H+R%3BHarold%2C+W+H%3BBrill%2C+A+B&rft.aulast=Susskind&rft.aufirst=H&rft.date=1988-03-01&rft.volume=1&rft.issue=3&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=The+European+respiratory+journal&rft.issn=09031936&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-08-08 N1 - Date created - 1988-08-08 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Chloroprene and isoprene: cytogenetic studies in mice. AN - 78258368; 3288837 AB - Groups of male B6C3F1 mice (n = 15) were exposed for 6 h per day to ambient air, to chloroprene (12, 32, 80, 200 p.p.m.) or to isoprene (438, 1750 and 7000 p.p.m.) on 12 days. These compounds are the 2-chloro and the 2-methyl analogues, respectively, of 1,3-butadiene, a genotoxic and carcinogenic chemical in B6C3F1 mice. Exposure to chloroprene resulted in a 100% incidence of mortality among the mice exposed to 200 p.p.m. At concentrations of 80 p.p.m. and below, chloroprene neither induced a significant increase in chromosomal aberrations (CA), sister chromatid exchanges (SCE) or micronucleated erythrocytes, nor significantly altered the rate of erythropoiesis or of bone marrow cellular proliferation kinetics. However, the mitotic index (MI) in the bone marrow of chloroprene-exposed mice was significantly increased. Under similar conditions, exposure to isoprene induced significant increases at all concentrations in the frequency of SCE in bone marrow cells and in the levels of micronucleated polychromatic erythrocytes (PCE) and of micronucleated normochromatic erythrocytes in peripheral blood. In addition, a significant lengthening of the bone marrow average generation time and a significant decrease in the percentage of circulating PCE was detected. However, exposure to isoprene did not induce in bone marrow a significant increase in the frequency of CA nor did the exposure significantly alter the MI. The dose-response curves for SCE and micronuclei induction were non-linear, appearing to saturate at 438 and 1750 p.p.m., respectively. These results suggest that, similarly to butadiene, inhaled isoprene can be expected to induce tumors at multiple sites in B6C3F1 mice.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Mutagenesis AU - Tice, R R AU - Boucher, R AU - Luke, C A AU - Paquette, D E AU - Melnick, R L AU - Shelby, M D AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 141 EP - 146 VL - 3 IS - 2 SN - 0267-8357, 0267-8357 KW - Butadienes KW - 0 KW - Hemiterpenes KW - Mutagens KW - Pentanes KW - isoprene KW - 0A62964IBU KW - Chloroprene KW - 126-99-8 KW - Index Medicus KW - Mice, Inbred Strains KW - Erythrocytes -- drug effects KW - Bone Marrow -- pathology KW - Animals KW - Dose-Response Relationship, Drug KW - Erythrocytes -- cytology KW - Mice KW - Bone Marrow -- drug effects KW - Male KW - Butadienes -- toxicity KW - Sister Chromatid Exchange -- drug effects KW - Chromosome Aberrations KW - Chloroprene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78258368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Chloroprene+and+isoprene%3A+cytogenetic+studies+in+mice.&rft.au=Tice%2C+R+R%3BBoucher%2C+R%3BLuke%2C+C+A%3BPaquette%2C+D+E%3BMelnick%2C+R+L%3BShelby%2C+M+D&rft.aulast=Tice&rft.aufirst=R&rft.date=1988-03-01&rft.volume=3&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=02678357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-15 N1 - Date created - 1988-07-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. AN - 78127406; 3347214 AB - In order to assess the potential of cytogenetic determinations on peripheral blood lymphocytes as a means of monitoring human populations subject to low level occupational and environmental exposures to chemical mutagens and carcinogens, accurate baseline data are required. Accordingly, we have determined mean frequencies of chromosomal aberrations and of sister-chromatid exchanges, their variances, and the sources of this variance in a cohort of 353 healthy employees of the Brookhaven National Laboratory. A detailed protocol was adopted for blood sampling, lymphocyte culture, cytogenetic preparation and scoring in order to minimize variation from these potential sources. Scoring was divided between the Oak Ridge and the Brookhaven groups with duplicate scoring sufficient to evaluate and minimize the effect of any differences between laboratories or between individual scorers. In all, the data include 71,950 cells scored for chromosomal aberrations and 16,898 cells scored for sister-chromatid exchanges. The mean unadjusted frequency of sister-chromatid exchanges was 8.29 +/- 0.08/cell. As reported in other studies, cigarette smoking very significantly influenced sister-chromatid exchange frequencies; in our study the mean for smokers was 9.0 +/- 0.2, while that for non-smokers was 8.1 +/- 0.1/cell. The mean frequency was statistically higher in females than in males, regardless of smoking status. On the other hand, age of the subject did not significantly influence sister-chromatid exchange frequencies. Curiously, the subject's total white cell count did influence sister-chromatid exchange frequency. No other source of variation was found. The frequencies of chromosomal aberrations of all types were determined. The frequency of the most common unequivocal chromatid type, the chromatid deletion, was 0.81 +/- 0.05%, that of the most common unequivocal chromosome type, the dicentric, was 0.16 +/- 0.02%. No statistically significant influence was found of age or sex, nor of any other parameter tested, on the frequency of any chromosomal aberration type, with the single exception of long acentric fragments, often "supernumerary", believed to represent X chromosomes precociously separated at the centromere. Such fragments were significantly more frequent in samples from females than those from males, and showed a significant positive regression on age. JF - Mutation research AU - Bender, M A AU - Preston, R J AU - Leonard, R C AU - Pyatt, B E AU - Gooch, P C AU - Shelby, M D AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/03// PY - 1988 DA - March 1988 SP - 421 EP - 433 VL - 204 IS - 3 SN - 0027-5107, 0027-5107 KW - Solvents KW - 0 KW - Index Medicus KW - Mass Screening KW - Aneuploidy KW - Chromatids -- ultrastructure KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Solvents -- adverse effects KW - Smoking -- adverse effects KW - Chromosomes -- ultrastructure KW - Radiation Genetics KW - Male KW - Female KW - Sister Chromatid Exchange KW - Chromosome Aberrations KW - Lymphocytes -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78127406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Chromosomal+aberration+and+sister-chromatid+exchange+frequencies+in+peripheral+blood+lymphocytes+of+a+large+human+population+sample.&rft.au=Bender%2C+M+A%3BPreston%2C+R+J%3BLeonard%2C+R+C%3BPyatt%2C+B+E%3BGooch%2C+P+C%3BShelby%2C+M+D&rft.aulast=Bender&rft.aufirst=M&rft.date=1988-03-01&rft.volume=204&rft.issue=3&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-21 N1 - Date created - 1988-04-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Complete nucleotide sequence and deduced amino acid sequence of the ompT gene of Escherichia coli K-12. AN - 20188758; 8737003 JF - Nucleic Acids Research AU - Grodberg, J AU - Lundrigan, M D AU - Toledo, D L AU - Mangel, W F AU - Dunn, J J AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/02/11/ PY - 1988 DA - 1988 Feb 11 SP - 1209 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 16 IS - 3 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Nucleotide sequence KW - Escherichia coli KW - OmpT protein KW - Amino acid sequence KW - J 02310:Genetics & Taxonomy KW - N 14815:Nucleotide Sequence KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20188758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Complete+nucleotide+sequence+and+deduced+amino+acid+sequence+of+the+ompT+gene+of+Escherichia+coli+K-12.&rft.au=Grodberg%2C+J%3BLundrigan%2C+M+D%3BToledo%2C+D+L%3BMangel%2C+W+F%3BDunn%2C+J+J&rft.aulast=Grodberg&rft.aufirst=J&rft.date=1988-02-11&rft.volume=16&rft.issue=3&rft.spage=1209&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nucleotide sequence; OmpT protein; Amino acid sequence; Escherichia coli ER - TY - JOUR T1 - Effects of deuteration on hematopoiesis in the mouse. AN - 78117693; 2831349 AB - Mice ingesting 30 to 50% D2O (heavy water, deuterium oxide) developed a dose-dependent depression of formed peripheral blood elements in 4 to 9 days. The principal mechanism of anemia and thrombocytopenia is impaired hematopoiesis. Despite pancytopenia in the peripheral blood, bone marrow cellularity and morphology remained normal. Upon replacement of D2O with tap water, platelet and neutrophil concentrations returned to normal within 48 to 72 hr. In contrast, blood lymphocyte concentrations remained low for several weeks. B-lymphocytes may be more affected by deuteration than other lymphocyte subsets. In vivo reticuloendothelial cell function, as assessed by 51Cr-labeled sheep erythrocyte clearance, was unaffected by D2O. Although a dose-dependent decrease in fluid intake occurred during deuteration, hematocytopenia was not a consequence of dehydration. In view of the known kinetics of D2O in biological systems, the rapid response of myeloid elements to deuteration must be due primarily to the solvent (nonmetabolic) isotope effect. Prolonged deuteration has proven toxic when included in regimens for treatment of neoplasia, including leukemia, in animal models. The present study shows that modulation of hematopoiesis by D2O is possible without invoking the toxicities associated with prolonged deuteration. JF - The Journal of pharmacology and experimental therapeutics AU - Adams, W H AU - Adams, D G AD - Medical Department, Brookhaven National Laboratory, Upton, New York. Y1 - 1988/02// PY - 1988 DA - February 1988 SP - 633 EP - 639 VL - 244 IS - 2 SN - 0022-3565, 0022-3565 KW - Deuterium KW - AR09D82C7G KW - Deuterium Oxide KW - J65BV539M3 KW - Index Medicus KW - Erythrocytes -- drug effects KW - Bone Marrow -- pathology KW - Animals KW - Dose-Response Relationship, Drug KW - Blood Platelets -- drug effects KW - Mice KW - Lymphocytes -- drug effects KW - Bone Marrow -- drug effects KW - Leukocyte Count KW - Female KW - Dehydration -- chemically induced KW - Platelet Count KW - Water Intoxication KW - Deuterium -- toxicity KW - Hematopoiesis -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78117693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Effects+of+deuteration+on+hematopoiesis+in+the+mouse.&rft.au=Adams%2C+W+H%3BAdams%2C+D+G&rft.aulast=Adams&rft.aufirst=W&rft.date=1988-02-01&rft.volume=244&rft.issue=2&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-04-12 N1 - Date created - 1988-04-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Activation of silent transposable elements. AN - 78484774; 2845915 AB - It is well known among maize geneticists that agents that cause chromosome breakage can activate quiescent transposable elements. However, other than temporarily relieving position effect, it is difficult to understand how these events can lead directly to activation. One possibility is that chromosome breakage can initiate a process in the cell resulting in a higher rate of spontaneous mutation. Such a system could be analogous to the SOS response of Escherichia coli in which an error-prone repair system is induced. Chemical mutagens that cause little chromosome breakage but add bulky adducts to the DNA can induce the SOS response. In seed homozygous for a1-m2(8004), wx-m8, no active Spm, that had been treated with ethyl methanesulfonate, we observed activation of Spm at the rate of 1.1 x 10(-4). The spontaneous rate of activation in this material was 1.2 x 10(-5). Most of the activation events occurred as single kernels. This result contrasts with sectors covering at least one-eighth of the ear that would have been expected if activation had occurred as a direct result of mutagenesis in the mature kernel. The late timing of these events suggests that the activation, in most instances, may not be the direct result of chemical mutagenesis. JF - Basic life sciences AU - Burr, B AU - Burr, F A AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1988 PY - 1988 DA - 1988 SP - 317 EP - 323 VL - 47 SN - 0090-5542, 0090-5542 KW - DNA Transposable Elements KW - 0 KW - DNA KW - 9007-49-2 KW - Ethyl Methanesulfonate KW - 9H154DI0UP KW - Index Medicus KW - DNA Repair KW - Ethyl Methanesulfonate -- pharmacology KW - DNA Damage KW - Suppression, Genetic KW - Crosses, Genetic KW - Mutation KW - Methylation KW - Female KW - DNA -- drug effects KW - Gene Expression Regulation KW - Zea mays -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78484774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Activation+of+silent+transposable+elements.&rft.au=Burr%2C+B%3BBurr%2C+F+A&rft.aulast=Burr&rft.aufirst=B&rft.date=1988-01-01&rft.volume=47&rft.issue=&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-11-23 N1 - Date created - 1988-11-23 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Relevance of phenotypic variation in risk assessment: the scientific viewpoint. AN - 78198310; 3365212 JF - Basic life sciences AU - Setlow, R B AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988 PY - 1988 DA - 1988 SP - 1 EP - 5 VL - 43 SN - 0090-5542, 0090-5542 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Humans KW - Dose-Response Relationship, Radiation KW - Skin Neoplasms -- genetics KW - Phenotype KW - Genetic Variation KW - Ataxia Telangiectasia -- genetics KW - DNA Repair KW - Sunlight -- adverse effects KW - Environmental Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78198310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+life+sciences&rft.atitle=Relevance+of+phenotypic+variation+in+risk+assessment%3A+the+scientific+viewpoint.&rft.au=Setlow%2C+R+B&rft.aulast=Setlow&rft.aufirst=R&rft.date=1988-01-01&rft.volume=43&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Basic+life+sciences&rft.issn=00905542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-06-03 N1 - Date created - 1988-06-03 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - What is a 'low dose' of radiation? AN - 78090690; 3257468 AB - Although the expression of radiation-induced biological effects and responses may be at either the cell, organ or organism level, induction of some of these phenomena (e.g. cancer of clastogenic and genetic effects) can have their origin in the interaction of a single charged particle with the target-containing volume (TCV) of the cell, e.g. the cell nucleus. However, the independent variable now used in both organ and cell population studies, the absorbed dose to the organ, provides no information directly on particle-TCV interactions. Even if calculated as a mean to an organized population of cells, the absorbed dose becomes a composite and confounded quantity, (FzN), in which F is the fraction of TCVs 'hit' by a particle during a given exposure, z is the mean value of z1, the energy absorbed in the TCV in a single hit, and N is the mean number of hits per affected TCV. Scientific precepts demand the avoidance of such confounded variables by achieving their isolation. The needed separation can be effected by the use of microdosimetric techniques, which make it possible to hold one component quantity constant while the others are varied. As an example, low-level radiation exposure (LLE) can be used to hold F at a constant value of 0.2 where, on average, there is but one hit per TCV. The probability of a cellular quantal response, as a function of z1 only, can then be determined by use of LLE to radiations covering a wide span of LETs. Conversely, the effect of varying only the fraction of cells hit can be studied by holding z constant. This can be accomplished by working within a narrow band of LET, but only in the LLE range. The effectiveness of preirradiation altering cell sensitivity as a function of the number of hits per TCV can be determined by working within, and somewhat above, the LLE range. In either risk assessment or the application of radiation as a pretreatment, minimal consequences can be assured only if very low-level exposure is employed in order that F will be small, and if the exposure is in a field of radiation of very low LET so that z1 will be as small as possible. That is to say, exposure conditions with low consequences cannot be specified in terms of any single quantity. JF - International journal of radiation biology and related studies in physics, chemistry, and medicine AU - Bond, V P AU - Feinendegen, L E AU - Booz, J AD - Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1988/01// PY - 1988 DA - January 1988 SP - 1 EP - 12 VL - 53 IS - 1 SN - 0020-7616, 0020-7616 KW - Index Medicus KW - Space life sciences KW - Energy Transfer KW - Dose-Response Relationship, Radiation KW - Radiation Effects KW - Radiation Dosage -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78090690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+biology+and+related+studies+in+physics%2C+chemistry%2C+and+medicine&rft.atitle=What+is+a+%27low+dose%27+of+radiation%3F&rft.au=Bond%2C+V+P%3BFeinendegen%2C+L+E%3BBooz%2C+J&rft.aulast=Bond&rft.aufirst=V&rft.date=1988-01-01&rft.volume=53&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+biology+and+related+studies+in+physics%2C+chemistry%2C+and+medicine&rft.issn=00207616&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-03-17 N1 - Date created - 1988-03-17 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Transposon tagging and molecular analysis of the maize regulatory locus opaque-2. AN - 81087197; 2823388 AB - Genetic analyses suggested that the opaque-2 (o2) locus in maize acts as a positive, transacting, transcriptional activator of the zein seed storage-protein genes. Because isolation of the gene is requisite to understanding the molecular details of this regulation, transposon mutagenesis with the transposable element suppressor-mutator (Spm) was carried out, and three mutable o2 alleles were obtained. One of these alleles contained an 8.3-kilobase autonomous Spm, another a 6.8-kilobase nonautonomous Spm, and the third an unidentified transposon that is unrelated to Spm. A DNA sequence flanking the autonomous Spm insertion was verified to be o2-specific and provided a probe to clone a wild-type allele. Northern blots indicated that the gene is expressed in wild-type endosperm but not in leaf tissues or in endosperms homozygous for a mutant allele of the O2 gene. A transcript was detected in endosperms homozygous for mutations at opaque-7 and floury-2, an indication that O2 expression is independent of these two other putative regulators of zein synthesis. JF - Science (New York, N.Y.) AU - Schmidt, R J AU - Burr, F A AU - Burr, B AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1987/11/13/ PY - 1987 DA - 1987 Nov 13 SP - 960 EP - 963 VL - 238 IS - 4829 SN - 0036-8075, 0036-8075 KW - DNA Transposable Elements KW - 0 KW - DNA Restriction Enzymes KW - EC 3.1.21.- KW - Index Medicus KW - Alleles KW - Homozygote KW - Nucleic Acid Hybridization KW - Mutation KW - Zea mays -- genetics KW - Cloning, Molecular KW - Plants -- genetics KW - Genes, Regulator UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/81087197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Transposon+tagging+and+molecular+analysis+of+the+maize+regulatory+locus+opaque-2.&rft.au=Schmidt%2C+R+J%3BBurr%2C+F+A%3BBurr%2C+B&rft.aulast=Schmidt&rft.aufirst=R&rft.date=1987-11-13&rft.volume=238&rft.issue=4829&rft.spage=960&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-09 N1 - Date created - 1987-12-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Waves in a partially saturated layered half-space; analytic formulation AN - 51509506; 2007-007706 JF - Bulletin of the Seismological Society of America AU - Philippacopoulos, A J Y1 - 1987/10/01/ PY - 1987 DA - 1987 Oct 01 SP - 1838 EP - 1853 PB - Seismological Society of America, Berkeley, CA VL - 77 IS - 5 SN - 0037-1106, 0037-1106 KW - P-waves KW - body waves KW - guided waves KW - numerical analysis KW - unsaturated zone KW - porous materials KW - mathematical models KW - elastic waves KW - Rayleigh waves KW - layered materials KW - boundary element analysis KW - saturated zone KW - surface waves KW - phase velocity KW - half-space KW - propagation KW - seismic waves KW - wave dispersion KW - S-waves KW - amplitude KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51509506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+the+Seismological+Society+of+America&rft.atitle=Waves+in+a+partially+saturated+layered+half-space%3B+analytic+formulation&rft.au=Philippacopoulos%2C+A+J&rft.aulast=Philippacopoulos&rft.aufirst=A&rft.date=1987-10-01&rft.volume=77&rft.issue=5&rft.spage=1838&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+the+Seismological+Society+of+America&rft.issn=00371106&rft_id=info:doi/ L2 - http://bssa.geoscienceworld.org/cgi/reprint/77/5/1838 http://bssa.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 40 N1 - PubXState - CA N1 - Document feature - illus. N1 - Last updated - 2016-10-25 N1 - CODEN - BSSAAP N1 - SubjectsTermNotLitGenreText - amplitude; body waves; boundary element analysis; elastic waves; guided waves; half-space; layered materials; mathematical models; numerical analysis; P-waves; phase velocity; porous materials; propagation; Rayleigh waves; S-waves; saturated zone; seismic waves; surface waves; unsaturated zone; wave dispersion ER - TY - JOUR T1 - Measurement of lung volume with 81Krm in a dynamic scintigram. AN - 77844037; 3684105 AB - The meaning of 81Krm counts obtained in a dynamic series of gated lung ventilation scans was evaluated in terms of flow rate, lung volume, or the flow/volume ratio. Flow and volume signals were recorded together with scintigraphic events in 29 subjects breathing 81Krm and after its decay, 127Xe as a tracer of lung volume. Gated ventilation scans and respiratory signals were reconstructed. Statistical analyses were carried out for linear regressions between total normalized counts detected by the gamma camera and (1) flow rate, (2) lung volume and (3) flow/volume ratio. Inspiration and expiration were analysed separately. For both isotopes, the best correlation was obtained between counts and lung volume (r greater than 0.93). No correlation was obtained between counts and flow rate or flow/volume ratio. Thus, we conclude that 81Krm count variations in gated scans correlate well with tidal volume. JF - Nuclear medicine communications AU - Cinotti, L AU - Susskind, H AU - Zubal, I G AU - Meignan, M AU - Bennett, G W AU - Slosman, D AU - Brill, A B AD - Brookhaven National Laboratory, Upton, New York. Y1 - 1987/07// PY - 1987 DA - July 1987 SP - 479 EP - 488 VL - 8 IS - 7 SN - 0143-3636, 0143-3636 KW - Krypton Radioisotopes KW - 0 KW - Index Medicus KW - Lung Volume Measurements -- methods KW - Pulmonary Ventilation KW - Pneumoconiosis -- diagnostic imaging KW - Ventilation-Perfusion Ratio KW - Humans KW - Radionuclide Imaging KW - Lung -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77844037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+medicine+communications&rft.atitle=Measurement+of+lung+volume+with+81Krm+in+a+dynamic+scintigram.&rft.au=Cinotti%2C+L%3BSusskind%2C+H%3BZubal%2C+I+G%3BMeignan%2C+M%3BBennett%2C+G+W%3BSlosman%2C+D%3BBrill%2C+A+B&rft.aulast=Cinotti&rft.aufirst=L&rft.date=1987-07-01&rft.volume=8&rft.issue=7&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Nuclear+medicine+communications&rft.issn=01433636&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-21 N1 - Date created - 1987-12-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Common misinterpretations of the "linear, no-threshold" relationship used in radiation protection. AN - 77841993; 3685248 AB - Absorbed dose D is shown to be a composite variable, the product of the fraction of cells hit (IH) and the mean "dose" (hit size) z to those cells. D is suitable for use with high level exposure (HLE) to radiation and its resulting acute organ effects because, since IH = 1.0, it approximates closely enough the mean energy density in the cell as well as in the organ. However, with low level exposure (LLE) to radiation and its consequent probability of cancer induction from a single cell, stochastic delivery of energy to cells results in a wide distribution of hit sizes z, and the expected mean value, z, is constant with exposure. Thus, with LLE, only IH varies with D so that the apparent proportionality between "dose" and the fraction of cells transformed is misleading. This proportionality therefore does not mean that any (cell) dose, no matter how small, can be lethal. Rather, it means that, in the exposure of a population of individual organisms consisting of the constituent relevant cells, there is a small probability of particle-cell interactions which transfer energy. The probability of a cell transforming and initiating a cancer can only be greater than zero if the hit size ("dose") to the cell is large enough. Otherwise stated, if the "dose" is defined at the proper level of biological organization, namely, the cell and not the organ, only a large dose z to that cell is effective. JF - Radiation and environmental biophysics AU - Bond, V P AU - Sondhaus, C A AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973. Y1 - 1987 PY - 1987 DA - 1987 SP - 253 EP - 261 VL - 26 IS - 4 SN - 0301-634X, 0301-634X KW - Index Medicus KW - Risk Factors KW - Cells -- radiation effects KW - Models, Theoretical KW - Radiation Protection KW - Dose-Response Relationship, Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77841993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+and+environmental+biophysics&rft.atitle=Common+misinterpretations+of+the+%22linear%2C+no-threshold%22+relationship+used+in+radiation+protection.&rft.au=Bond%2C+V+P%3BSondhaus%2C+C+A&rft.aulast=Bond&rft.aufirst=V&rft.date=1987-01-01&rft.volume=26&rft.issue=4&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Radiation+and+environmental+biophysics&rft.issn=0301634X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1987-12-31 N1 - Date created - 1987-12-31 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - BOOK T1 - The impacts of CERCLA, RCRA and state programs on site remediation; a case study AN - 52367126; 2000-033577 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Siet, Kenneth AU - Davies, Kathryn L A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - aquifer vulnerability KW - water quality KW - Resource Conservation and Recovery Act KW - programs KW - contaminant plumes KW - Superfund KW - regulations KW - reclamation KW - public policy KW - impact statements KW - government agencies KW - pollution KW - decision-making KW - remediation KW - potability KW - ground water KW - aquifers KW - case studies KW - planning KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52367126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Siet%2C+Kenneth%3BDavies%2C+Kathryn+L&rft.aulast=Siet&rft.aufirst=Kenneth&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=The+impacts+of+CERCLA%2C+RCRA+and+state+programs+on+site+remediation%3B+a+case+study&rft.title=The+impacts+of+CERCLA%2C+RCRA+and+state+programs+on+site+remediation%3B+a+case+study&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - PubXState - NY N1 - Document feature - illus. N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - When to renovate?; remediation or reparations AN - 52367096; 2000-033574 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Bishop, K C, III A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - protection KW - hazardous waste KW - aquifer vulnerability KW - water quality KW - toxic materials KW - Superfund KW - pollution KW - decision-making KW - chemical waste KW - petroleum products KW - drinking water KW - remediation KW - ground water KW - aquifers KW - organic compounds KW - wellhead protection KW - water treatment KW - hydrocarbons KW - risk assessment KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52367096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Bishop%2C+K+C%2C+III&rft.aulast=Bishop&rft.aufirst=K&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=When+to+renovate%3F%3B+remediation+or+reparations&rft.title=When+to+renovate%3F%3B+remediation+or+reparations&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 22 N1 - PubXState - NY N1 - Document feature - 2 tables N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Engineering aspects of point vs non-point sources of groundwater pollution AN - 52367073; 2000-033561 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Dean, J David AU - Gaboury, David R A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - soils KW - septic systems KW - hazardous waste KW - leaking underground storage tanks KW - water supply KW - agricultural waste KW - contaminant plumes KW - engineering properties KW - pollutants KW - landfills KW - pollution KW - chemical waste KW - nonpoint sources KW - seepage KW - potability KW - ground water KW - aquifers KW - waste management KW - liquid waste KW - leachate KW - waste disposal KW - point sources KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52367073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Dean%2C+J+David%3BGaboury%2C+David+R&rft.aulast=Dean&rft.aufirst=J&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Engineering+aspects+of+point+vs+non-point+sources+of+groundwater+pollution&rft.title=Engineering+aspects+of+point+vs+non-point+sources+of+groundwater+pollution&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 15 N1 - PubXState - NY N1 - Document feature - 1 table N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Some problems in the engineering of groundwater cleanup AN - 52366019; 2000-033569 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Armstrong, John M A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - water quality KW - biodegradation KW - monitoring KW - contaminant plumes KW - pollutants KW - regulations KW - reclamation KW - pollution KW - techniques KW - bioremediation KW - remediation KW - ground water KW - aquifers KW - pump tests KW - sampling KW - decontamination KW - bacteria KW - risk assessment KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52366019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Armstrong%2C+John+M&rft.aulast=Armstrong&rft.aufirst=John&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Some+problems+in+the+engineering+of+groundwater+cleanup&rft.title=Some+problems+in+the+engineering+of+groundwater+cleanup&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - PubXState - NY N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Techniques for delineating subsurface organic contamination; a case study AN - 52365993; 2000-033568 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Pitchford, Ann M AU - Mazzella, Aldo T AU - Heyse, Edward A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - aquifer vulnerability KW - water quality KW - concentration KW - monitoring KW - contaminant plumes KW - spatial data KW - cartography KW - pollutants KW - pollution KW - techniques KW - resistivity KW - environmental analysis KW - ground water KW - aquifers KW - case studies KW - water table KW - fluctuations KW - organic compounds KW - detection KW - hydrocarbons KW - xylene KW - aromatic hydrocarbons KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52365993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Pitchford%2C+Ann+M%3BMazzella%2C+Aldo+T%3BHeyse%2C+Edward&rft.aulast=Pitchford&rft.aufirst=Ann&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Techniques+for+delineating+subsurface+organic+contamination%3B+a+case+study&rft.title=Techniques+for+delineating+subsurface+organic+contamination%3B+a+case+study&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 4 N1 - PubXState - NY N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Synthetic organic contaminants and pesticides in groundwater; an emerging health problem AN - 52365789; 2000-033563 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Zaki, Mahfouz H A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - United States KW - chlorinated hydrocarbons KW - aquifer vulnerability KW - water quality KW - contaminant plumes KW - environmental analysis KW - ground water KW - Suffolk County New York KW - halogenated hydrocarbons KW - chemical composition KW - concentration KW - monitoring KW - pollutants KW - pollution KW - petroleum products KW - aquifers KW - organic compounds KW - New York KW - detection KW - hydrocarbons KW - risk assessment KW - trichloroethylene KW - pesticides KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52365789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Zaki%2C+Mahfouz+H&rft.aulast=Zaki&rft.aufirst=Mahfouz&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Synthetic+organic+contaminants+and+pesticides+in+groundwater%3B+an+emerging+health+problem&rft.title=Synthetic+organic+contaminants+and+pesticides+in+groundwater%3B+an+emerging+health+problem&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 3 N1 - PubXState - NY N1 - Document feature - 1 table N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Extent of groundwater contamination in the U.S; an overview AN - 52365755; 2000-033560 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Mlay, Marian AU - Dee, Norbert A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - water use KW - United States KW - water quality KW - water supply KW - pollutants KW - regulations KW - public policy KW - water management KW - pollution KW - techniques KW - Safe Drinking Water Act KW - nonpoint sources KW - drinking water KW - ground water KW - aquifers KW - water treatment KW - risk assessment KW - water pollution KW - point sources KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52365755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Mlay%2C+Marian%3BDee%2C+Norbert&rft.aulast=Mlay&rft.aufirst=Marian&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Extent+of+groundwater+contamination+in+the+U.S%3B+an+overview&rft.title=Extent+of+groundwater+contamination+in+the+U.S%3B+an+overview&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 5 N1 - PubXState - NY N1 - Document feature - 2 tables N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Physical and chemical treatment of contaminated groundwater at hazardous waste sites AN - 52365158; 2000-033576 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Higgins, Thomas E AU - Romanow, Stephen A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - United States KW - hazardous waste KW - aquifer vulnerability KW - Chisman Creek KW - Chesapeake Bay KW - air stripping KW - soil vapor extraction KW - reclamation KW - environmental analysis KW - remediation KW - ground water KW - York County Virginia KW - decontamination KW - water treatment KW - Indiana KW - chemical properties KW - discharge KW - water supply KW - Virginia KW - Marion County Indiana KW - pollutants KW - injection KW - pollution KW - Indianapolis Indiana KW - adsorption KW - aquifers KW - case studies KW - physical properties KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52365158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Higgins%2C+Thomas+E%3BRomanow%2C+Stephen&rft.aulast=Higgins&rft.aufirst=Thomas&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Physical+and+chemical+treatment+of+contaminated+groundwater+at+hazardous+waste+sites&rft.title=Physical+and+chemical+treatment+of+contaminated+groundwater+at+hazardous+waste+sites&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 4 N1 - PubXState - NY N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Managing groundwater data AN - 52365123; 2000-033567 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Kaplan, Edward AU - Meinhold, Anne F A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - aquifer vulnerability KW - water quality KW - spatial data KW - data acquisition KW - landfills KW - data processing KW - water management KW - ground water KW - interactive techniques KW - data bases KW - construction KW - demand KW - water use KW - protection KW - pollution KW - standardization KW - decision-making KW - information management KW - aquifers KW - detection KW - runoff KW - waste disposal KW - water wells KW - point sources KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52365123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Kaplan%2C+Edward%3BMeinhold%2C+Anne+F&rft.aulast=Kaplan&rft.aufirst=Edward&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Managing+groundwater+data&rft.title=Managing+groundwater+data&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 7 N1 - PubXState - NY N1 - Document feature - 3 tables N1 - SuppNotes - Includes appendices N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Survey of groundwater contamination in Massachusetts AN - 52365085; 2000-033562 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Roy, Steven P A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - water use KW - United States KW - protection KW - aquifer vulnerability KW - programs KW - concentration KW - water supply KW - monitoring KW - pollutants KW - pollution KW - environmental analysis KW - drinking water KW - ground water KW - aquifers KW - Massachusetts KW - surveys KW - water wells KW - water resources KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52365085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Roy%2C+Steven+P&rft.aulast=Roy&rft.aufirst=Steven&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Survey+of+groundwater+contamination+in+Massachusetts&rft.title=Survey+of+groundwater+contamination+in+Massachusetts&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 3 N1 - PubXState - NY N1 - Document feature - 2 tables N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Control of groundwater contamination; case studies AN - 52363895; 2000-033570 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Mercer, Jean W AU - Faust, Charles R AU - Truschel, Anthony D AU - Cohen, Robert M A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - United States KW - aquifer vulnerability KW - water quality KW - agricultural waste KW - Love Canal KW - contaminant plumes KW - reclamation KW - water management KW - power plants KW - chemical waste KW - environmental analysis KW - Rocky Mountain Arsenal KW - remediation KW - ground water KW - waste management KW - controls KW - decontamination KW - leachate KW - Lipari landfill KW - water use KW - protection KW - toxic materials KW - Niagara County New York KW - pollution KW - migration of elements KW - hydroelectric energy KW - preventive measures KW - Adams County Colorado KW - aquifers KW - case studies KW - New York KW - runoff KW - industrial waste KW - New Jersey KW - waste disposal KW - Colorado KW - land use KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52363895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Mercer%2C+Jean+W%3BFaust%2C+Charles+R%3BTruschel%2C+Anthony+D%3BCohen%2C+Robert+M&rft.aulast=Mercer&rft.aufirst=Jean&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Control+of+groundwater+contamination%3B+case+studies&rft.title=Control+of+groundwater+contamination%3B+case+studies&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 17 N1 - PubXState - NY N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Best management practices for point and nonpoint sources of groundwater contamination AN - 52363728; 2000-033571 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Jaffe, Martin A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - United States KW - aquifer vulnerability KW - water quality KW - contaminant plumes KW - regulations KW - reclamation KW - water management KW - chemical waste KW - nonpoint sources KW - remediation KW - ground water KW - waste management KW - controls KW - protection KW - best management practices KW - pollution KW - preventive measures KW - aquifers KW - runoff KW - industrial waste KW - policy KW - waste disposal KW - point sources KW - land use KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52363728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Jaffe%2C+Martin&rft.aulast=Jaffe&rft.aufirst=Martin&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Best+management+practices+for+point+and+nonpoint+sources+of+groundwater+contamination&rft.title=Best+management+practices+for+point+and+nonpoint+sources+of+groundwater+contamination&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - PubXState - NY N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Technical issues of groundwater data AN - 52363690; 2000-033565 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Braids, Olin C AU - Spreizer, Gisella M AU - Shkuda, Gregory K A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - water quality KW - monitoring KW - data acquisition KW - effluents KW - statistical analysis KW - pollution KW - decision-making KW - remediation KW - ground water KW - aquifers KW - waste management KW - trend-surface analysis KW - discharge KW - accuracy KW - point sources KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52363690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Braids%2C+Olin+C%3BSpreizer%2C+Gisella+M%3BShkuda%2C+Gregory+K&rft.aulast=Braids&rft.aufirst=Olin&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Technical+issues+of+groundwater+data&rft.title=Technical+issues+of+groundwater+data&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 4 N1 - PubXState - NY N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Overview of groundwater monitoring techniques AN - 52363050; 2000-033564 JF - Symposium on Detection, control, and renovation of contaminated ground water AU - Schowengerdt, Richard W A2 - Dee, Norbert A2 - McTernan, William F. A2 - Kaplan, Edward Y1 - 1987 PY - 1987 DA - 1987 PB - American Society of Civil Engineers, New York, NY SN - 0872625958 KW - hazardous waste KW - aquifer vulnerability KW - water quality KW - toxic materials KW - monitoring KW - contaminant plumes KW - data acquisition KW - landfills KW - pollution KW - observation wells KW - techniques KW - decision-making KW - remediation KW - ground water KW - aquifers KW - detection KW - waste disposal KW - construction KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52363050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Schowengerdt%2C+Richard+W&rft.aulast=Schowengerdt&rft.aufirst=Richard&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0872625958&rft.btitle=Overview+of+groundwater+monitoring+techniques&rft.title=Overview+of+groundwater+monitoring+techniques&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Symposium on Detection, control, and renovation of contaminated ground water N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2000-01-01 N1 - Number of references - 7 N1 - PubXState - NY N1 - Document feature - 2 tables N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Acidification and anadromous fish of Atlantic estuaries AN - 13795611; 198800537 AB - In October 1985, a conference was convened by the Hudson River Foundation to discuss possible explanations for the severe declines in populations of anadromous fish (Atlantic salmon, American shad, hickory shad, alewives, blueback herring, striped bass), and some species resident in coastal streams (yellow perch, white perch), which had occurred along sections of the North American east coast since 1970. Available data indicated that stream and river acidification, toxic metals and organic compounds, eutrophication and over fishing had all contributed to the decline. The conference agreed that acid deposition was a major factor in this context, and that future research should investigate episodic decreases in stream and river pH, review the water chemistry records for streams and rivers where fish populations have declined, evaluate the contributions of wet and dry deposition of sulphur and nitrogen to surface water acidity in the coastal plain, evaluate the role of nitrification, and define the susceptibility of fish to acidity and evaluate aluminium concentrations. JF - Water, Air, & Soil Pollution AU - Hendrey, G R AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1987 PY - 1987 DA - 1987 SP - 1 EP - 6 VL - 35 IS - 1/2 SN - 0049-6979, 0049-6979 KW - Surface water (s/a lakes,ponds,reservoirs,streams) KW - Reduction KW - Fish (see also individual groups listed below) KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13795611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Acidification+and+anadromous+fish+of+Atlantic+estuaries&rft.au=Hendrey%2C+G+R&rft.aulast=Hendrey&rft.aufirst=G&rft.date=1987-01-01&rft.volume=35&rft.issue=1%2F2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Case Study. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Inactivation of human and simian rotaviruses by ozone AN - 13794071; 198800491 AB - The ability of ozone to inactivate simian rotavirus SA-11 and human rotavirus type 2 was studied at 4C using single-particle virus stocks. Concentrations of 0.25 mg per litre or greater rapidly inactivated both virus types at all pH levels tested, though the human strain was more sensitive. Identical experiments with chlorine indicated little difference in virucidal activity with respect to rotavirus inactivation. Concentrations were again 0.25 mg per litre or greater. JF - Applied and Environmental Microbiology AU - Vaughn, J M AU - Chen, Y S AU - Lindburg, K AU - Morales, D AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1987 PY - 1987 DA - 1987 SP - 2218 EP - 2221 VL - 53 IS - 9 SN - 0099-2240, 0099-2240 KW - Viruses (-general-) (see also individ grps below) KW - Aqualine Abstracts KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13794071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Inactivation+of+human+and+simian+rotaviruses+by+ozone&rft.au=Vaughn%2C+J+M%3BChen%2C+Y+S%3BLindburg%2C+K%3BMorales%2C+D&rft.aulast=Vaughn&rft.aufirst=J&rft.date=1987-01-01&rft.volume=53&rft.issue=9&rft.spage=2218&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Soil-structure interaction; Vol. 1, Influence of layering AN - 51030833; 1999-027664 JF - NUREG/CR (United States. Nuclear Regulatory Commission) AU - Philippacopoulos, A J Y1 - 1986/04// PY - 1986 DA - April 1986 SP - 81 PB - U. S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, Washington, DC SN - 0278-1670, 0278-1670 KW - computer programs KW - soil mechanics KW - laboratory studies KW - foundations KW - experimental studies KW - soil-structure interface KW - data processing KW - seismic response KW - layered materials KW - structures KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51030833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Philippacopoulos%2C+A+J&rft.aulast=Philippacopoulos&rft.aufirst=A&rft.date=1986-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Soil-structure+interaction%3B+Vol.+1%2C+Influence+of+layering&rft.title=Soil-structure+interaction%3B+Vol.+1%2C+Influence+of+layering&rft.issn=02781670&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1999-01-01 N1 - Number of references - 52 N1 - Availability - National Technical Information Service, Springfield, VA, United States (USA) N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - computer programs; data processing; experimental studies; foundations; laboratory studies; layered materials; seismic response; soil mechanics; soil-structure interface; structures ER - TY - JOUR T1 - Regional distribution of ventilation assessed by Kr-81m scintigraphy employing temporal Fourier transform. AN - 77359235; 3451755 AB - Temporal Fourier analysis was applied to Kr-81m ventilation scintigraphy to determine the amplitude (AMP1) and phase (PHA1) of the first harmonic of a single composite respiratory cycle and to compare regional patterns in subjects with obstructive pulmonary disease (COPD) and nonobstructed subjects. Six nonobstructed subjects, three subjects with small airway disease, six subjects with COPD, and one subject with restrictive disease were investigated. The mean value of the functional PHA1 image (PHA1m) correlated negatively with 1-second forced expiratory volume (FEV1) (r = -0.801, P less than .001), with %FEV1/FVC (r = -0.636, P less than .01) and maximum midexpiratory flow rate (FEF25-75%) (r = -0.723, P less than .002), and correlated positively with residual volume (r = 0.640, P less than .01). PHA1m values for the six subjects with COPD were significantly higher (t = 2.359, P less than .05) than for the ten nonobstructed subjects. Display of phase and amplitude functional images permits a visual evaluation of the regional distribution of ventilation to be made. Regional abnormalities of air flow were detected in obstructed subjects, and the presence of airway obstruction could be predicted. Dynamic ventilation imaging, therefore, appears to be a potentially useful noninvasive technique to assess lung impairment on a localized level. JF - American journal of physiologic imaging AU - Slosman, D AU - Susskind, H AU - Cinotti, L AU - van Giessen, J W AU - Brill, A B AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1986 PY - 1986 DA - 1986 SP - 5 EP - 11 VL - 1 IS - 1 SN - 0885-8276, 0885-8276 KW - Krypton Radioisotopes KW - 0 KW - Index Medicus KW - Pneumoconiosis -- diagnostic imaging KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Coal Mining KW - Pneumoconiosis -- physiopathology KW - Fourier Analysis KW - Male KW - Radionuclide Imaging KW - Lung -- diagnostic imaging KW - Respiration KW - Lung -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77359235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiologic+imaging&rft.atitle=Regional+distribution+of+ventilation+assessed+by+Kr-81m+scintigraphy+employing+temporal+Fourier+transform.&rft.au=Slosman%2C+D%3BSusskind%2C+H%3BCinotti%2C+L%3Bvan+Giessen%2C+J+W%3BBrill%2C+A+B&rft.aulast=Slosman&rft.aufirst=D&rft.date=1986-01-01&rft.volume=1&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiologic+imaging&rft.issn=08858276&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-25 N1 - Date created - 1988-07-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Quantitative comparison of regional distributions of inhaled Tc-99m DTPA aerosol and Kr-81m gas in coal miners' lungs. AN - 77359182; 3330442 AB - Regional distributions of deposited Tc-99m diethylenetriamine pentaacetate aerosol (DPTA) and of Kr-81m were compared in the upright lungs of 22 coal miners with nonembolic pulmonary disease. Pixel-by-pixel distributions of Kr-81m and DPTA corrected for lung volume, as well as DTPA/Kr-81m ratios, were determined by computer analysis in each lung and plotted against lung position. DTPA was preferentially deposited in the basal regions of 36/44 lungs. In the same lungs, Kr-81m was preferentially distributed in the apical regions of 18 lungs, bilaterally in six subjects. Similar DTPA and Kr-81m regional distributions throughout both lungs were obtained in only 11 (50%) subjects. No significant correlations were found between regional particle deposition and pulmonary function measurements. The effects of gravity-related lung pressure gradients and ventilation-related particle residence time on the deposition of DTPA may limit its usefulness when quantitative information is required to evaluate subtle changes in ventilation in nonembolic pulmonary patients and for basic studies of ventilation and perfusion. JF - American journal of physiologic imaging AU - Susskind, H AU - Brill, A B AU - Harold, W H AD - Medical Research Center, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1986 PY - 1986 DA - 1986 SP - 67 EP - 76 VL - 1 IS - 2 SN - 0885-8276, 0885-8276 KW - Aerosols KW - 0 KW - Gases KW - Krypton Radioisotopes KW - Organometallic Compounds KW - Pentetic Acid KW - 7A314HQM0I KW - Technetium Tc 99m Pentetate KW - VW78417PU1 KW - Index Medicus KW - Humans KW - Aged KW - Middle Aged KW - Administration, Inhalation KW - Male KW - Radionuclide Imaging KW - Organometallic Compounds -- pharmacokinetics KW - Organometallic Compounds -- administration & dosage KW - Pneumoconiosis -- diagnostic imaging KW - Lung -- diagnostic imaging KW - Krypton Radioisotopes -- pharmacokinetics KW - Pneumoconiosis -- metabolism KW - Pentetic Acid -- administration & dosage KW - Coal Mining KW - Lung -- metabolism KW - Pentetic Acid -- pharmacokinetics KW - Krypton Radioisotopes -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77359182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiologic+imaging&rft.atitle=Quantitative+comparison+of+regional+distributions+of+inhaled+Tc-99m+DTPA+aerosol+and+Kr-81m+gas+in+coal+miners%27+lungs.&rft.au=Susskind%2C+H%3BBrill%2C+A+B%3BHarold%2C+W+H&rft.aulast=Susskind&rft.aufirst=H&rft.date=1986-01-01&rft.volume=1&rft.issue=2&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiologic+imaging&rft.issn=08858276&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1988-07-25 N1 - Date created - 1988-07-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-21 ER - TY - JOUR T1 - Ground motion considerations for nuclear power plant design with emphasis on soil-structure interaction aspects AN - 52839639; 1996-041678 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Kennedy, R P AU - Power, M S AU - Chang, C Y A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 101 EP - 138 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - United States KW - soil profiles KW - stiffness KW - acceleration KW - frequency KW - models KW - accelerograms KW - spatial variations KW - strong motion KW - soil-structure interface KW - Ferndale earthquake 1975 KW - ground motion KW - propagation KW - nuclear facilities KW - earthquakes KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52839639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Ground+motion+considerations+for+nuclear+power+plant+design+with+emphasis+on+soil-structure+interaction+aspects&rft.au=Kennedy%2C+R+P%3BPower%2C+M+S%3BChang%2C+C+Y&rft.aulast=Kennedy&rft.aufirst=R&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 23 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acceleration; accelerograms; design; earthquakes; Ferndale earthquake 1975; frequency; ground motion; models; nuclear facilities; propagation; soil profiles; soil-structure interface; spatial variations; stiffness; strong motion; United States ER - TY - JOUR T1 - Workshop on Soil-structure interaction AN - 52839591; 1996-041672 JF - NUREG/CP (United States, Nuclear Regulatory Commission) A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 404 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - soil mechanics KW - soil-structure interface KW - symposia KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52839591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Workshop+on+Soil-structure+interaction&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - SuppNotes - Individual papers are cited separately N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - soil mechanics; soil-structure interface; symposia ER - TY - JOUR T1 - Introduction and overview of SSI issues AN - 52839340; 1996-041673 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Chokshi, Nilesh AU - Bagchi, Goutam A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 2 EP - 10 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - models KW - soil mechanics KW - finite element analysis KW - attenuation KW - soil-structure interface KW - statistical analysis KW - analysis KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52839340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Introduction+and+overview+of+SSI+issues&rft.au=Chokshi%2C+Nilesh%3BBagchi%2C+Goutam&rft.aulast=Chokshi&rft.aufirst=Nilesh&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - analysis; attenuation; finite element analysis; models; soil mechanics; soil-structure interface; statistical analysis ER - TY - JOUR T1 - Stochastic response of rigid foundations AN - 52838926; 1996-041684 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Pais, Artur Luna AU - Kausel, Eduardo A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 251 EP - 259 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - body waves KW - numerical analysis KW - stiffness KW - elastic waves KW - frequency KW - structures KW - models KW - kinematics KW - foundations KW - rigidity KW - stochastic processes KW - SH-waves KW - seismic waves KW - S-waves KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52838926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Stochastic+response+of+rigid+foundations&rft.au=Pais%2C+Artur+Luna%3BKausel%2C+Eduardo&rft.aulast=Pais&rft.aufirst=Artur&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 9 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - body waves; elastic waves; foundations; frequency; kinematics; models; numerical analysis; rigidity; S-waves; seismic waves; SH-waves; stiffness; stochastic processes; structures ER - TY - JOUR T1 - Some comments on ground-motion aspects of the proposed revised standard review plan AN - 52838856; 1996-041677 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - King, Jerry L A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 92 EP - 99 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - soil mechanics KW - soil-structure interface KW - Fourier analysis KW - ground motion KW - data processing KW - focus KW - elastic waves KW - seismic waves KW - earthquakes KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52838856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Some+comments+on+ground-motion+aspects+of+the+proposed+revised+standard+review+plan&rft.au=King%2C+Jerry+L&rft.aulast=King&rft.aufirst=Jerry&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 12 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - data processing; earthquakes; elastic waves; focus; Fourier analysis; ground motion; seismic waves; soil mechanics; soil-structure interface ER - TY - JOUR T1 - Uncertainties in the estimates of seismic ground motion at a site made using the site specific spectra approach AN - 52838825; 1996-041675 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Bernreuter, D L AU - Chen, J C A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 42 EP - 77 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - United States KW - numerical models KW - Imperial County California KW - statistical analysis KW - acceleration KW - Eastern U.S. KW - Oroville California KW - El Centro California KW - California KW - Ferndale California KW - seismicity KW - Butte County California KW - ground motion KW - earthquakes KW - regression analysis KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52838825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Uncertainties+in+the+estimates+of+seismic+ground+motion+at+a+site+made+using+the+site+specific+spectra+approach&rft.au=Bernreuter%2C+D+L%3BChen%2C+J+C&rft.aulast=Bernreuter&rft.aufirst=D&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 16 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acceleration; Butte County California; California; earthquakes; Eastern U.S.; El Centro California; Ferndale California; ground motion; Imperial County California; numerical models; Oroville California; regression analysis; seismicity; statistical analysis; United States ER - TY - JOUR T1 - Summary and conclusions AN - 52838520; 1996-041690 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Chokshi, N C AU - Graves, H L AU - Philippacopoulos, A J A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 396 EP - 404 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - soil mechanics KW - soil-structure interface KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52838520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Summary+and+conclusions&rft.au=Chokshi%2C+N+C%3BGraves%2C+H+L%3BPhilippacopoulos%2C+A+J&rft.aulast=Chokshi&rft.aufirst=N&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=396&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - soil mechanics; soil-structure interface ER - TY - JOUR T1 - Site response; a critical problem in soil-structure interaction analyses for embedded structures AN - 52838484; 1996-041683 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Seed, H Bolton AU - Lysmer, John A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 233 EP - 250 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - body waves KW - soil profiles KW - guided waves KW - site exploration KW - stiffness KW - acceleration KW - elastic waves KW - frequency KW - analysis KW - Rayleigh waves KW - boundary conditions KW - structures KW - observations KW - attenuation KW - spatial variations KW - surface waves KW - soil-structure interface KW - Love waves KW - ground motion KW - half-space KW - seismic waves KW - earthquakes KW - S-waves KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52838484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Site+response%3B+a+critical+problem+in+soil-structure+interaction+analyses+for+embedded+structures&rft.au=Seed%2C+H+Bolton%3BLysmer%2C+John&rft.aulast=Seed&rft.aufirst=H&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 55 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acceleration; analysis; attenuation; body waves; boundary conditions; earthquakes; elastic waves; frequency; ground motion; guided waves; half-space; Love waves; observations; Rayleigh waves; S-waves; seismic waves; site exploration; soil profiles; soil-structure interface; spatial variations; stiffness; structures; surface waves ER - TY - JOUR T1 - Earthquake simulation experience and experimental observations AN - 52838424; 1996-041686 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Higgins, Cornelius J AU - Dass, William C A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 284 EP - 330 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - experimental studies KW - accelerometers KW - elastic waves KW - frequency KW - simulation KW - uniaxial tests KW - structures KW - observations KW - models KW - attenuation KW - soil-structure interface KW - ground motion KW - nuclear facilities KW - seismic waves KW - earthquakes KW - instruments KW - arrays KW - amplitude KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52838424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Earthquake+simulation+experience+and+experimental+observations&rft.au=Higgins%2C+Cornelius+J%3BDass%2C+William+C&rft.aulast=Higgins&rft.aufirst=Cornelius&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 8 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - accelerometers; amplitude; arrays; attenuation; earthquakes; elastic waves; experimental studies; frequency; ground motion; instruments; models; nuclear facilities; observations; seismic waves; simulation; soil-structure interface; structures; uniaxial tests ER - TY - JOUR T1 - Experimental verification of soil/structure interaction methods AN - 52837807; 1996-041688 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Miller, C A AU - Costantino, C J AU - Philippacopoulos, A J A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 341 EP - 365 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - methods KW - Fukushima Japan KW - experimental studies KW - Far East KW - statistical analysis KW - frequency KW - structures KW - models KW - finite element analysis KW - soil-structure interface KW - nuclear facilities KW - Miyagi earthquake 1978 KW - Honshu KW - Asia KW - earthquakes KW - Japan KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52837807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Experimental+verification+of+soil%2Fstructure+interaction+methods&rft.au=Miller%2C+C+A%3BCostantino%2C+C+J%3BPhilippacopoulos%2C+A+J&rft.aulast=Miller&rft.aufirst=C&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 5 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; earthquakes; experimental studies; Far East; finite element analysis; frequency; Fukushima Japan; Honshu; Japan; methods; Miyagi earthquake 1978; models; nuclear facilities; soil-structure interface; statistical analysis; structures ER - TY - JOUR T1 - Some perspectives on dynamics of soil-structure interaction AN - 52837755; 1996-041682 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Veletsos, A S A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 213 EP - 232 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - strain KW - footings KW - stiffness KW - data processing KW - acceleration KW - elastic waves KW - elastic constants KW - seismic response KW - computers KW - attenuation KW - dynamics KW - buildings KW - velocity KW - body waves KW - stress KW - research KW - structures KW - physical properties KW - soil-structure interface KW - ground motion KW - half-space KW - seismic waves KW - shear modulus KW - earthquakes KW - S-waves KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52837755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Some+perspectives+on+dynamics+of+soil-structure+interaction&rft.au=Veletsos%2C+A+S&rft.aulast=Veletsos&rft.aufirst=A&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 17 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acceleration; attenuation; body waves; buildings; computers; data processing; dynamics; earthquakes; elastic constants; elastic waves; footings; ground motion; half-space; physical properties; research; S-waves; seismic response; seismic waves; shear modulus; soil-structure interface; stiffness; strain; stress; structures; velocity ER - TY - JOUR T1 - EPRI research on soil-structure interaction AN - 52836999; 1996-041685 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Tang, H T A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 262 EP - 283 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - statistical analysis KW - elastic waves KW - frequency KW - research KW - variations KW - structures KW - models KW - finite element analysis KW - soil-structure interface KW - ground motion KW - vibration KW - Electric Power Research Institute KW - nuclear facilities KW - seismic waves KW - earthquakes KW - instruments KW - design KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52836999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=EPRI+research+on+soil-structure+interaction&rft.au=Tang%2C+H+T&rft.aulast=Tang&rft.aufirst=H&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 5 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - design; earthquakes; elastic waves; Electric Power Research Institute; finite element analysis; frequency; ground motion; instruments; models; nuclear facilities; research; seismic waves; soil-structure interface; statistical analysis; structures; variations; vibration ER - TY - JOUR T1 - Random-vibration models of free-field seismic ground motion for soil-structure interaction AN - 52836934; 1996-041676 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - McGuire, Robin K A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 78 EP - 90 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - United States KW - body waves KW - data processing KW - elastic waves KW - Eastern U.S. KW - observations KW - models KW - California KW - attenuation KW - strong motion KW - soil-structure interface KW - Fourier analysis KW - earthquake prediction KW - ground motion KW - vibration KW - seismic waves KW - earthquakes KW - S-waves KW - amplitude KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52836934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Random-vibration+models+of+free-field+seismic+ground+motion+for+soil-structure+interaction&rft.au=McGuire%2C+Robin+K&rft.aulast=McGuire&rft.aufirst=Robin&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 9 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - amplitude; attenuation; body waves; California; data processing; earthquake prediction; earthquakes; Eastern U.S.; elastic waves; Fourier analysis; ground motion; models; observations; S-waves; seismic waves; soil-structure interface; strong motion; United States; vibration ER - TY - JOUR T1 - Empirical prediction of free-field ground motion using statistical regression models AN - 52836511; 1996-041674 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Campbell, Kenneth W A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 12 EP - 41 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - statistical analysis KW - magnitude KW - acceleration KW - models KW - attenuation KW - strong motion KW - soil-structure interface KW - earthquake prediction KW - ground motion KW - earthquakes KW - regression analysis KW - arrays KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52836511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Empirical+prediction+of+free-field+ground+motion+using+statistical+regression+models&rft.au=Campbell%2C+Kenneth+W&rft.aulast=Campbell&rft.aufirst=Kenneth&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 22 N1 - Availability - U.S. Nuclear Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acceleration; arrays; attenuation; earthquake prediction; earthquakes; ground motion; magnitude; models; regression analysis; soil-structure interface; statistical analysis; strong motion ER - TY - JOUR T1 - Role of experiments in soil-structure interaction methodology verification AN - 52835798; 1996-041687 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Srinivasan, M G AU - Kot, C A AU - Hsieh, B J A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 331 EP - 340 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - soils KW - methods KW - experimental studies KW - site exploration KW - models KW - attenuation KW - soil-structure interface KW - ground motion KW - buildings KW - vibration KW - nuclear facilities KW - earthquakes KW - arrays KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52835798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Role+of+experiments+in+soil-structure+interaction+methodology+verification&rft.au=Srinivasan%2C+M+G%3BKot%2C+C+A%3BHsieh%2C+B+J&rft.aulast=Srinivasan&rft.aufirst=M&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 10 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - arrays; attenuation; buildings; earthquakes; experimental studies; ground motion; methods; models; nuclear facilities; site exploration; soil-structure interface; soils; vibration ER - TY - JOUR T1 - Uncertainties in soil-structure interaction analyses AN - 52835764; 1996-041680 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Costantino, C J AU - Kuo, P T AU - Miller, C A AU - Philippacopoulos, A J A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 163 EP - 193 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - body waves KW - numerical analysis KW - statistical analysis KW - elastic waves KW - analysis KW - models KW - history KW - finite element analysis KW - strong motion KW - soil-structure interface KW - ground motion KW - velocity KW - nuclear facilities KW - seismic waves KW - S-waves KW - design KW - arrays KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52835764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Uncertainties+in+soil-structure+interaction+analyses&rft.au=Costantino%2C+C+J%3BKuo%2C+P+T%3BMiller%2C+C+A%3BPhilippacopoulos%2C+A+J&rft.aulast=Costantino&rft.aufirst=C&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 26 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - analysis; arrays; body waves; design; elastic waves; finite element analysis; ground motion; history; models; nuclear facilities; numerical analysis; S-waves; seismic waves; soil-structure interface; statistical analysis; strong motion; velocity ER - TY - JOUR T1 - Numerical-experimental approach to the S.S.I. analysis AN - 52834779; 1996-041689 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Castoldi, A AU - Muzzi, F AU - Panzeri, P AU - Pezzoli, P AU - Ruggeri, G AU - Martelli, A AU - Masoni, P A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 366 EP - 394 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - in situ KW - three-dimensional models KW - numerical analysis KW - stiffness KW - frequency KW - seismic response KW - structures KW - soil-structure interface KW - boreholes KW - blasting KW - buildings KW - testing KW - nuclear facilities KW - instruments KW - arrays KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52834779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Numerical-experimental+approach+to+the+S.S.I.+analysis&rft.au=Castoldi%2C+A%3BMuzzi%2C+F%3BPanzeri%2C+P%3BPezzoli%2C+P%3BRuggeri%2C+G%3BMartelli%2C+A%3BMasoni%2C+P&rft.aulast=Castoldi&rft.aufirst=A&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 5 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - arrays; blasting; boreholes; buildings; frequency; in situ; instruments; nuclear facilities; numerical analysis; seismic response; soil-structure interface; stiffness; structures; testing; three-dimensional models ER - TY - JOUR T1 - Specification of ground motion input for SSI analyses AN - 52834706; 1996-041679 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Roesset, Jose M A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 139 EP - 161 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - soil mechanics KW - elastic waves KW - frequency KW - kinematics KW - attenuation KW - soil-structure interface KW - ground motion KW - half-space KW - seismic waves KW - earthquakes KW - design KW - amplitude KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52834706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Specification+of+ground+motion+input+for+SSI+analyses&rft.au=Roesset%2C+Jose+M&rft.aulast=Roesset&rft.aufirst=Jose&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 21 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - amplitude; attenuation; design; earthquakes; elastic waves; frequency; ground motion; half-space; kinematics; seismic waves; soil mechanics; soil-structure interface ER - TY - JOUR T1 - Licensing concerns in SSI methodology AN - 52833156; 1996-041681 JF - NUREG/CP (United States, Nuclear Regulatory Commission) AU - Hadjian, A H A2 - Graves, H. L. A2 - Philippacopoulos, A. J. Y1 - 1986 PY - 1986 DA - 1986 SP - 195 EP - 212 PB - United States Nuclear Regulatory Commission, Washington, DC SN - 0270-6482, 0270-6482 KW - methods KW - body waves KW - statistical analysis KW - elastic waves KW - frequency KW - finite element analysis KW - soil-structure interface KW - ground motion KW - velocity KW - half-space KW - seismic waves KW - compressive strength KW - earthquakes KW - S-waves KW - amplitude KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52833156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.atitle=Licensing+concerns+in+SSI+methodology&rft.au=Hadjian%2C+A+H&rft.aulast=Hadjian&rft.aufirst=A&rft.date=1986-01-01&rft.volume=&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=NUREG%2FCP+%28United+States%2C+Nuclear+Regulatory+Commission%29&rft.issn=02706482&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Workshop on Soil-structure interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - Number of references - 6 N1 - Availability - U.S. Nuclearl Regulatory Commission, Washington, DC, United States N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - amplitude; body waves; compressive strength; earthquakes; elastic waves; finite element analysis; frequency; ground motion; half-space; methods; S-waves; seismic waves; soil-structure interface; statistical analysis; velocity ER - TY - JOUR T1 - Inactivation of human and simian rotaviruses by chlorine AN - 13821848; 198603444 AB - In experiments, conducted at 4C and pH 6, 7 or 8 with single particle virus stocks, complete (5 log) inactivation of simian rotavirus SA-11 and human rotavirus type 2 (Wa) was achieved in 20 seconds at free chlorine concentrations as low as 0.3 mg per litre. Disinfection efficiency decreased with increasing pH but this was only appreciable at free chlorine concentrations below 0.3 mg per litre. Overall, human rotavirus appeared to be slightly more resistant to chlorine treatment than SA-11 but the difference was not considered significant: the authors concluded that the simian rotavirus strain was a satisfactory model for human rotavirus inactivation studies in chlorinated systems. JF - Applied and Environmental Microbiology AU - Vaughn, J M AU - Chen, Y S AU - Thomas, M Z AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1986 PY - 1986 DA - 1986 SP - 391 EP - 394 VL - 51 IS - 2 SN - 0099-2240, 0099-2240 KW - Modelling (-general-) KW - Reduction KW - Viruses (-general-) (see also individ grps below) KW - Water authorities KW - Aqualine Abstracts KW - AQ:00000 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13821848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Inactivation+of+human+and+simian+rotaviruses+by+chlorine&rft.au=Vaughn%2C+J+M%3BChen%2C+Y+S%3BThomas%2C+M+Z&rft.aulast=Vaughn&rft.aufirst=J&rft.date=1986-01-01&rft.volume=51&rft.issue=2&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Identifying human populations at risk from acid deposition mobilized materials in drinking water supplies: a preliminary pilot study AN - 13821394; 198601913 AB - The indirect health risks from acidified drinking water, particularly those due to the mobilization of aluminium, asbestos, cadmium, and lead from catchments or water distribution systems, are discussed. A conceptual model is presented for estimating human exposure to the materials mobilized by acid deposition in catchments and drinking water distribution systems, and an example of its application to the Adirondack Park region in New York State, is given. JF - Water Quality Bulletin AU - Moskowitz, P D AU - Coveney, E A AU - Hamilton, L D AU - Kaplan, E AU - Medeiros, W H AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1986 PY - 1986 DA - 1986 SP - 12 EP - 18,59-60 VL - 11 IS - 1 KW - Hazard KW - Modelling (-general-) KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13821394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Quality+Bulletin&rft.atitle=Identifying+human+populations+at+risk+from+acid+deposition+mobilized+materials+in+drinking+water+supplies%3A+a+preliminary+pilot+study&rft.au=Moskowitz%2C+P+D%3BCoveney%2C+E+A%3BHamilton%2C+L+D%3BKaplan%2C+E%3BMedeiros%2C+W+H&rft.aulast=Moskowitz&rft.aufirst=P&rft.date=1986-01-01&rft.volume=11&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Water+Quality+Bulletin&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Acid rain effects on soil and aquatic microbial processes AN - 13803843; 198702407 AB - The literature is reviewed and the effects of acid rain and acidity on soil and aquatic microbial processes is discussed. There are 101 references. For aquatic systems, microbial population distribution and activity in water and sediments, and the decomposition of organic matter are discussed. Acidification appeared to inhibit decomposition processes. Only limited studies were found which dealt with the effects of acidity on aquatic micro-organisms in sensitive areas receiving acid rain. JF - Experientia AU - Francis, A J AD - Brookhaven National Laboratory, Long Island, N.Y. Y1 - 1986 PY - 1986 DA - 1986 SP - 455 EP - 465 VL - 42 IS - 5 KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13803843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experientia&rft.atitle=Acid+rain+effects+on+soil+and+aquatic+microbial+processes&rft.au=Francis%2C+A+J&rft.aulast=Francis&rft.aufirst=A&rft.date=1986-01-01&rft.volume=42&rft.issue=5&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Experientia&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Chemical composition of precipitation at Long Island, NY AN - 13802260; S198826056 AB - A major issue in acid precipitation research was the identification of aqueous-phase reaction pathways for the oxidation of sulphate and nitrate. Among the aqueous-phase oxidants, hydrogen peroxide was considered the most important. Hydrogen peroxide concentration in collected rainwater samples was determined, together with various other chemical species (ionic hydrogen, nitrate, sulphate, ammonium, calcium, sodium and chloride). Chemical analyses were carried out on 387 sequential precipitation samples (collection time 30 minutes) on 96 days from October 1983 to June 1985. Maximal hydrogen peroxide concentrations occurred in summer (120 uM), being 6 times greater than the winter level. There was also strong diurnal variation, with maximal concentration in the afternoon, and minimal after midnight. Photochemical control of hydrogen peroxide production is suggested by these observations. Nitrate concentration showed a diurnal variation, with maximum at noon, but no seasonal dependence. Sodium and chloride showed high concentrations, with a seasonal dependence opposite to that of the other chemical species, namely, low in summer. The ion concentrations, together with their ratios and possible sources are discussed. JF - Water, Air, & Soil Pollution AU - Lee, Y N AU - Shen, J AU - Klotz, P J AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1986 PY - 1986 DA - 1986 SP - 143 EP - 152 VL - 30 IS - 1/2 SN - 0049-6979, 0049-6979 KW - Night KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13802260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Chemical+composition+of+precipitation+at+Long+Island%2C+NY&rft.au=Lee%2C+Y+N%3BShen%2C+J%3BKlotz%2C+P+J&rft.aulast=Lee&rft.aufirst=Y&rft.date=1986-01-01&rft.volume=30&rft.issue=1%2F2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Case Study. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Do continental shelves export organic matter? AN - 13794782; S198826500 AB - The shelf-edge exchange processes experiment was designed to test the export hypothesis which assumed that: there was an imbalance between primary production and heterotrophic use in coastal marine ecosystems; phytoplankton produced in the spring bloom was exported, with intensified organic carbon deposition being reflected in the sediments on the continental slope. Shelf carbon budget data obtained from the eastern U.S.A. did not support the export hypothesis. The export hypothesis was rejected, and it was concluded that only a small fraction of phytodetritus was exported, the fraction not consumed in spring being used on the continental shelf during the next stratified period. JF - Nature AU - Rowe, G T AU - Smith, S AU - Falkowski, P AU - Whitledge, T AU - Theroux, R AU - Phoel, W AU - Ducklow, H AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1986 PY - 1986 DA - 1986 SP - 559 EP - 561 VL - 324 IS - 6097 SN - 0028-0836, 0028-0836 KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13794782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Do+continental+shelves+export+organic+matter%3F&rft.au=Rowe%2C+G+T%3BSmith%2C+S%3BFalkowski%2C+P%3BWhitledge%2C+T%3BTheroux%2C+R%3BPhoel%2C+W%3BDucklow%2C+H&rft.aulast=Rowe&rft.aufirst=G&rft.date=1986-01-01&rft.volume=324&rft.issue=6097&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Growth-irradiance relationships in phytoplankton 1 AN - 1808720742; PQ0003339328 AB - The steady state growth rates of three species of marine phytoplankton, Thalassiosira weisflogii, Isochrysis galbana, and Prorocentrum micans, were followed in turbidostat culture. At each growth irradiance, photosynthesis and respiration were measured by following changes in oxygen. Together with measurements of optical absorption cross sections, cellular chlorophyll, carbon and nitrogen, and excretion rates as well as knowledge of the quantum flux, the quantum requirement for growth (1/ mu ) and photosynthesis (1/ sub(p)) were calculated. Our results suggest that variations in growth rate caused by changes in irradiance may be related to changes in respiration rates relative to growth as well as changes in optical absorption cross sections for a given species. Interspecific differences in growth rate at a given irradiance are not related to changes in respiration however, but are primarily attributable to differences in optical absorption cross sections normalized to chlorophyll a and differences in chlorophyll: carbon ratios. JF - Limnology and Oceanography AU - Falkowski, Paul G AU - Dubinsky, Zvy AU - Wyman, Kevin AD - Oceanographic Sciences Division, Brookhaven National Laboratory.Upton, New York 11973. Y1 - 1985/03// PY - 1985 DA - March 1985 SP - 311 EP - 321 PB - Association for the Sciences of Limnology and Oceanography VL - 30 IS - 2 SN - 0024-3590, 0024-3590 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Chlorophylls KW - Thalassiosira KW - Chlorophyll KW - Irradiance KW - Photosynthesis KW - Turbidostats KW - Optical properties KW - Respiration KW - Prorocentrum micans KW - Limnology KW - Phytoplankton KW - Cell culture KW - Isochrysis galbana KW - Growth KW - Carbon KW - Absorption KW - Growth rate KW - Marine KW - Plankton surveys KW - Carbon cycle KW - Growth Rates KW - Oxygen KW - Excretion KW - Nitrogen KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q1 08481:Productivity KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808720742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Growth-irradiance+relationships+in+phytoplankton+1&rft.au=Falkowski%2C+Paul+G%3BDubinsky%2C+Zvy%3BWyman%2C+Kevin&rft.aulast=Falkowski&rft.aufirst=Paul&rft.date=1985-03-01&rft.volume=30&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1985.30.2.0311 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Growth rate; Plankton surveys; Chlorophylls; Growth; Carbon; Respiration; Optical properties; Carbon cycle; Phytoplankton; Excretion; Oxygen; Chlorophyll; Turbidostats; Photosynthesis; Irradiance; Cell culture; Nitrogen; Absorption; Limnology; Growth Rates; Thalassiosira; Prorocentrum micans; Isochrysis galbana; Marine DO - http://dx.doi.org/10.4319/lo.1985.30.2.0311 ER - TY - RPRT T1 - Use of geographic information systems in ground water management AN - 51892867; 2004-014097 JF - Geographic information systems workshop AU - Kaplan, E AU - Meinhold, Anne AU - Naidu, J AU - Hauptmann, M AU - Opitz, Bruce K Y1 - 1985 PY - 1985 DA - 1985 SP - 12 KW - United States KW - regulations KW - public policy KW - water management KW - Nassau County New York KW - ground water KW - Suffolk County New York KW - New York KW - geographic information systems KW - information systems KW - Long Island KW - water resources KW - 21:Hydrogeology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51892867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Kaplan%2C+E%3BMeinhold%2C+Anne%3BNaidu%2C+J%3BHauptmann%2C+M%3BOpitz%2C+Bruce+K&rft.aulast=Kaplan&rft.aufirst=E&rft.date=1985-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Use+of+geographic+information+systems+in+ground+water+management&rft.title=Use+of+geographic+information+systems+in+ground+water+management&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geographic information systems workshop N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Availability - U. S. Army Engineering Topographic Laboratories (ETL), Fort Belvoir, VA, United States N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Continuous measurement of the dispersion of sewage sludge AN - 19241997; 5817945 AB - Three controlled sewage-sludge dumping experiments involving moving and stationary dumping in the New York Bight apex were conducted in July 1976; the goal was to obtain results on short-term spatial and temporal variations in sludge components in the water column after dumping events and to determine the length of time needed for the water column to return to the predumping state. Water-column properties measured before and after sludge discharge were temperature, salinity, dissolved oxygen, nutrient, and adenosine triphosphate. After the moving dump, which is associated with a large amount of turbulent mixing from the wake of the barge, sludge components were rapidly mixed within the pycnocline. Except for ammonium concentrations, the water column returned to predump conditions within 3 h after dumping. Horizontal underway (continuous) mapping of the sludge plume at the surface and at 1-, 6-, and 8-m depths showed the presence of several areas of sludge-seawater mixtures that appeared as oscillations in the concentration field. After the stationary dump, concentrations of sludge components (both dissolved and particulate) in the water column were greatest at approximate 5 m deep. Biological decomposition of sludge, as inferred from adenosine triphosphate production in dialysis bag experiments, occurred rapidly within 48 h after a moving dumping event. JF - Environmental Science and Technology AU - Oakley, SA AU - Duedall, I W AU - Parker, J H AU - Proni, J R Y1 - 1985 PY - 1985 DA - 1985 SP - 26 EP - 408 PB - John Willey and Sons, New York (USA) KW - ASFA 3: Aquatic Pollution & Environmental Quality KW - Sewage disposal KW - Ocean dumping KW - Marine KW - Sewage KW - Marine pollution KW - Pollution dispersion KW - Waste disposal KW - Effluents KW - Sludge KW - ANW, USA, New York Bight KW - Q5 08501:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19241997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aquatic+Science+%26+Fisheries+Abstracts+%28ASFA%29+3%3A+Aquatic+Pollution+%26+Environmental+Quality&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Oakley%2C+SA%3BDuedall%2C+I+W%3BParker%2C+J+H%3BProni%2C+J+R&rft.aulast=Oakley&rft.aufirst=SA&rft.date=1985-01-01&rft.volume=&rft.issue=&rft.spage=383&rft.isbn=&rft.btitle=Continuous+measurement+of+the+dispersion+of+sewage+sludge&rft.title=Continuous+measurement+of+the+dispersion+of+sewage+sludge&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Physical medium: Printed matter; Inc. 201 ref N1 - Last updated - 2014-05-07 ER - TY - JOUR T1 - A nodal coarse-mesh method for the efficient numerical solution of laminar flow problems AN - 13810813; S198720423 AB - A method for the efficient numerical solution of laminar flow problems was developed using a transverse integration procedure followed by the introduction of locally-defined Green's tensors of the transverse-integrated in-node Navier-Stokes and mass conservation equations. The nodal method was applied to the numerical solution of three incompressible fluid flow problems: fully developed flow between parallel plates, inlet flow between parallel plates and a modified driven cavity problem. The high accuracy of the method of very coarse meshes led to a high computational efficiency. JF - Journal of Computational Physics AU - Horak, W C AU - Dorning, JJ AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1985 PY - 1985 DA - 1985 SP - 405 EP - 440 VL - 59 IS - 3 KW - Aqualine Abstracts KW - AQ 00005:Underground Services and Water Use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13810813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Physics&rft.atitle=A+nodal+coarse-mesh+method+for+the+efficient+numerical+solution+of+laminar+flow+problems&rft.au=Horak%2C+W+C%3BDorning%2C+JJ&rft.aulast=Horak&rft.aufirst=W&rft.date=1985-01-01&rft.volume=59&rft.issue=3&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Physics&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Growth-irradiance relationships in phytoplankton AN - 13798241; S198824147 AB - The photosynthetic performance and growth-irradiance were compared in 3 marine species, the diatom Thalassiosira weisflogii, the chrysophyte Isochrysis galbana, and the dinoflagellate Prorocentrum micans, grown in turbidostat culture. The quantum requirements for growth and photosynthesis were calculated from measurements of optical absorption cross sections, cellular chlorophyll, carbon and nitrogen, excretion rates and quantum flux. Variations in growth rate caused by changes in irradiance could be related to changes in respiration rates relative to growth as well as changes in optical absorption cross sections for a given species. Interspecific differences in growth rate at a given irradiance were not related to changes in respiration, but were attributable to differences in optical absorption cross sections normalized to chlorophyll-a and differences in chlorophyll:carbon ratios. JF - Limnology and Oceanography AU - Falkowski, P G AU - Dubinsky, Z AU - Wyman, K AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1985 PY - 1985 DA - 1985 SP - 311 EP - 321 VL - 30 IS - 2 SN - 0024-3590, 0024-3590 KW - Quantum KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13798241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Growth-irradiance+relationships+in+phytoplankton&rft.au=Falkowski%2C+P+G%3BDubinsky%2C+Z%3BWyman%2C+K&rft.aulast=Falkowski&rft.aufirst=P&rft.date=1985-01-01&rft.volume=30&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Potential effects of gamma irradiation on the chemistry and alkalinity of brine in high-level nuclear waste repositories in rock salt AN - 50155977; 1995-029082 JF - Nuclear Technology AU - Panno, S V AU - Soo, P Y1 - 1984/11// PY - 1984 DA - November 1984 SP - 268 EP - 281 PB - American Nuclear Society and European Nuclear Society, Hinsdale, IL VL - 67 IS - 2 SN - 0029-5450, 0029-5450 KW - United States KW - aquifer vulnerability KW - irradiation KW - salt domes KW - isotopes KW - Eddy County New Mexico KW - New Mexico KW - radioactive waste KW - radioactive isotopes KW - transport KW - chemical properties KW - alkalinity KW - underground storage KW - porous materials KW - migration of elements KW - porosity KW - boundary conditions KW - aquifers KW - brines KW - underground installations KW - heat transfer KW - Carlsbad New Mexico KW - waste disposal KW - leaching KW - unconfined aquifers KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50155977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Technology&rft.atitle=Potential+effects+of+gamma+irradiation+on+the+chemistry+and+alkalinity+of+brine+in+high-level+nuclear+waste+repositories+in+rock+salt&rft.au=Panno%2C+S+V%3BSoo%2C+P&rft.aulast=Panno&rft.aufirst=S&rft.date=1984-11-01&rft.volume=67&rft.issue=2&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Nuclear+Technology&rft.issn=00295450&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1995-01-01 N1 - Number of references - 34 N1 - PubXState - IL N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - alkalinity; aquifer vulnerability; aquifers; boundary conditions; brines; Carlsbad New Mexico; chemical properties; Eddy County New Mexico; heat transfer; irradiation; isotopes; leaching; migration of elements; New Mexico; porosity; porous materials; radioactive isotopes; radioactive waste; salt domes; transport; unconfined aquifers; underground installations; underground storage; United States; waste disposal ER - TY - JOUR T1 - Review Article: two-phase flow; models and methods AN - 13832379; S198516813 AB - An extensive review article on the variety of two-phase flow models which have been derived, typically those relating to a mixture of water and air or of water and steam, although it is made clear that the models could apply to 'fields' such as mixtures of solids, liquids or gases. The first part of the review considers the models, first the case of the noninteracting fields, second, interacting fields, and then limiting cases. Different modelling methods are reviewed subsequently and several methods in current use are discussed to aid the selection of appropriate techniques for specific problems. JF - Journal of Computational Physics AU - Stewart, H B AU - Wendroff, B AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1984 PY - 1984 DA - 1984 SP - 363 EP - 409 VL - 56 IS - 3 KW - Modelling (-general-) KW - Two phase KW - Aqualine Abstracts KW - AQ 00005:Underground Services and Water Use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13832379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Physics&rft.atitle=Review+Article%3A+two-phase+flow%3B+models+and+methods&rft.au=Stewart%2C+H+B%3BWendroff%2C+B&rft.aulast=Stewart&rft.aufirst=H&rft.date=1984-01-01&rft.volume=56&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Physics&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - RPRT T1 - Northeast monitoring program cruise 83-03, R/V Cape Henlopen, 8-14 April 1983 : data report AN - 21022144; 8077840 JF - National Oceanic and Atmospheric Administration. [np]. May 1983. AU - Whitledge, Terry E. double prime 294233 AU - Bock, Karl von Y1 - 1983/05// PY - 1983 DA - May 1983 PB - National Oceanic and Atmospheric Administration KW - Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Water quality management Mid-Atlantic Bight. double prime 256718 KW - Water quality Mid-Atlantic BightAnalysis. double prime 256714 KW - Marine pollution Mid-Atlantic BightMeasurement. double prime 248535 KW - Data reports KW - USA, Delaware, Cape Henlopen KW - Oceanographic cruise data KW - M2 551.5:General (551.5) KW - Q5 08501:General KW - Q2 09101:General works UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21022144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aquatic+Science+%26+Fisheries+Abstracts+%28ASFA%29+3%3A+Aquatic+Pollution+%26+Environmental+Quality&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Whitledge%2C+Terry+E.+double+prime+294233%3BBock%2C+Karl+von&rft.aulast=Whitledge&rft.aufirst=Terry+E.+double+prime&rft.date=1983-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Northeast+monitoring+program+cruise+83-03%2C+R%2FV+Cape+Henlopen%2C+8-14+April+1983+%3A+data+report&rft.title=Northeast+monitoring+program+cruise+83-03%2C+R%2FV+Cape+Henlopen%2C+8-14+April+1983+%3A+data+report&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2016-12-21 ER - TY - BOOK T1 - Analysis and evaluation of a radioactive waste package retrieved from the Atlantic Ocean AN - 19250266; 5817808 AB - On 31 July 1976, a 300-liter radioactive waste package was retrieved from the Atlantic Ocean 2800-m depth disposal site, 38~'30'N, 72~'06'W. Container corrosion, matrix leach rate, and degradation studies were conducted at Brookhaven National Laboratory. The retrieved waste package comprised a 300-liter mild steel drum with no lid, which contained a cement concrete matrix. Markings on the concrete surface indicated that it had been disposed of in 1961. Within the concrete matrix a sealed steel vessel was found which contained some liquid and three wound filter assemblies. Although this vessel had a major indentation running along its length resulting from the pressure differential during descent in disposal, it had not leaked. The integrity of the concrete matrix had not degraded appreciably during 15 years in the ocean, as evidenced by visual observation, weight loss, and compressive strength measurements. A conservative estimate indicated that it would require a minimum of 300 years in this environment before the waste form would lose its integrity due to cement phase dissolution. Radiochemical analysis indicated the presence of super(137)Cs, super(134)Cs, and super(60)Co in both the concrete and the inner vessel. Based on the measured super(137)Cs distribution in concrete cores, a bulk leach rate of 2.4 x 10 super(-3) g cm super(-1) d super(-1) was calculated. This corresponds to an average fractional activity loss rate of 3.7 x 10 super(-2) y super(-1). Corrosion rates for general attack on the upper portion of the mild steel drum were 0.032 to 0.049 mm y super(-1), assuming a constant rate with no induction period. A lower limit for the rate of local pitting corrosion of 0.067 mm y super(-1) was determined. General thinning attack rates, an 18-guage (nominal 0.121-cm thickness) mild steel drum would require 25 to 37 y in this disposal environment before integrity loss due to corrosion. JF - Environmental Science and Technology AU - Colombo, P AU - Neilson, R M Y1 - 1983 PY - 1983 DA - 1983 SP - 32 EP - 268 PB - John Willey and Sons, New York (USA) SN - 0471097705 KW - ASFA 3: Aquatic Pollution & Environmental Quality KW - Radioactive waste disposal KW - Marine KW - Marine pollution KW - Waste disposal KW - Q5 08522:Protective measures and control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19250266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aquatic+Science+%26+Fisheries+Abstracts+%28ASFA%29+3%3A+Aquatic+Pollution+%26+Environmental+Quality&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Colombo%2C+P%3BNeilson%2C+R+M&rft.aulast=Colombo&rft.aufirst=P&rft.date=1983-01-01&rft.volume=&rft.issue=&rft.spage=237&rft.isbn=0471097705&rft.btitle=Analysis+and+evaluation+of+a+radioactive+waste+package+retrieved+from+the+Atlantic+Ocean&rft.title=Analysis+and+evaluation+of+a+radioactive+waste+package+retrieved+from+the+Atlantic+Ocean&rft.issn=01940287&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Physical medium: Printed matter; Incls. 592 refs N1 - Last updated - 2014-05-07 ER - TY - JOUR T1 - The pattern of distribution of dimethylbenz(a)anthracene in the Amazon molly, Poecilla formosa (Girard), after intraperitoneal injection AN - 13865993; S198410564 AB - Amazon mollies, Poecilla formosa, were injected intraperitoneally with labelled dimethylbenz(a)anthracene (DMBA). At 2 hours after injection, DMBA was present throughout the body, save in the brain and ovary. Enhanced deposition occurred at four sites: atrial macrophages, peritoneum, liver and exocrine pancreas. Little label remained after 400 hours. Label however, accumulated in the ameloblasts which secrete enamel cappings of the teeth and it has been suggested that this may be a mechanism whereby DMBA and its reactive products are sequestered and ultimately eliminated from the body when the teeth are shed. JF - Journal of Fish Biology AU - Woodhead, AD AU - Bornbusch, A AD - Brookhaven National Laboratory, New York Y1 - 1983 PY - 1983 DA - 1983 SP - 241 EP - 248 VL - 22 IS - 2 SN - 0022-1112, 0022-1112 KW - Jn - j. fish biol. KW - Pancreas KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13865993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Fish+Biology&rft.atitle=The+pattern+of+distribution+of+dimethylbenz%28a%29anthracene+in+the+Amazon+molly%2C+Poecilla+formosa+%28Girard%29%2C+after+intraperitoneal+injection&rft.au=Woodhead%2C+AD%3BBornbusch%2C+A&rft.aulast=Woodhead&rft.aufirst=AD&rft.date=1983-01-01&rft.volume=22&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Journal+of+Fish+Biology&rft.issn=00221112&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Accumulation of sediment-associated viruses in shellfish AN - 13865499; 198301570 AB - Studies on the accumulation of human viruses from polluted sediments by shellfish (Crassostrea virginica and Mercenaria mercenaria) are reported. Uptake of viruses was found to be greater when the sediment was disturbed and the sediment particles, with their associated viruses, were resuspended in the water column. The significance of the results in sampling sea water for viruses is discussed. JF - Applied and Environmental Microbiology AU - Landry, E F AU - Vaughn, J M AU - Vicale, T J AU - Mann, R AD - Brookhaven National Laboratory, N.Y. Y1 - 1983 PY - 1983 DA - 1983 SP - 238 EP - 247 VL - 45 IS - 1 SN - 0099-2240, 0099-2240 KW - Pollution (s/a contamination, individ grps below) KW - Sea water (see also marine -----) KW - Viruses (-general-) (see also individ grps below) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13865499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Accumulation+of+sediment-associated+viruses+in+shellfish&rft.au=Landry%2C+E+F%3BVaughn%2C+J+M%3BVicale%2C+T+J%3BMann%2C+R&rft.aulast=Landry&rft.aufirst=E&rft.date=1983-01-01&rft.volume=45&rft.issue=1&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Entrainment of viruses from septic tank leach fields through a shallow, sandy soil aquifer AN - 13859359; 198303557 AB - A study was carried out in Long Island, N.Y. , on the lateral transport of naturally occurring human viruses through a shallow aquifer receiving discharges from a subsurface sewage disposal system in sandy soil. Virus particles were recovered at down-gradient distances of 67 m and at aquifer depths of 18 m. The implications of these results for the siting of such sewage disposal systems and water supply wells are discussed briefly. The occurrence of viruses could not be correlated with either total or faecal coliform bacteria indicating the limitations of such bacterial indicators for virus contamination of groundwater. JF - Applied and Environmental Microbiology AU - Vaughn, J M AU - Landry, E F AU - Thomas, M Z AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1983 PY - 1983 DA - 1983 SP - 1474 EP - 1480 VL - 45 IS - 5 SN - 0099-2240, 0099-2240 KW - Viruses (-general-) (see also individ grps below) KW - Aqualine Abstracts KW - AQ 00001:Water Resources and Supplies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13859359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Entrainment+of+viruses+from+septic+tank+leach+fields+through+a+shallow%2C+sandy+soil+aquifer&rft.au=Vaughn%2C+J+M%3BLandry%2C+E+F%3BThomas%2C+M+Z&rft.aulast=Vaughn&rft.aufirst=J&rft.date=1983-01-01&rft.volume=45&rft.issue=5&rft.spage=1474&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - The effects of chronic exposure to asbestos fibres in the Amazon molly Poecilia formosa AN - 13852452; 198400677 AB - This paper describes the histopathology of lesions observed in Amazon mollies after 6 months exposure to low concentration of fine and coarse asbestos particles suspended in their aquarium water. Lesions were found only in the kidney, the major site of accumulation after entry through the intestinal mucosa, the gills and the heart. No abnormalities were observed in the liver, muscles or other tissues . There was no evidence of entry through the gill epithelium and injury appeared to be the result of physical abrasion by the particles. JF - Environment International AU - Woodhead, AD AU - Setlow, R B AU - Pond, V AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1983 PY - 1983 DA - 1983 SP - 173 EP - 176 VL - 9 IS - 3 SN - 0160-4120, 0160-4120 KW - Suspended KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13852452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+International&rft.atitle=The+effects+of+chronic+exposure+to+asbestos+fibres+in+the+Amazon+molly+Poecilia+formosa&rft.au=Woodhead%2C+AD%3BSetlow%2C+R+B%3BPond%2C+V&rft.aulast=Woodhead&rft.aufirst=AD&rft.date=1983-01-01&rft.volume=9&rft.issue=3&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Environment+International&rft.issn=01604120&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - SuppNotes - Publication focus: Experimental. N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Viruses in soils and groundwaters AN - 13835512; S198517104 AB - A review of reported occurrences, transport mechanisms and survival of viruses in soil and groundwater systems is presented. The possible routes of virus contamination of groundwater are discussed, and a critical assessment of virus infections attributed to the consumption of contaminated groundwater is given. Reports of soil or groundwater associated gastroenteritis outbreaks provided indications of a viral aetiology and were frequently associated with contamination of drinking water supplies by sewage from septic tanks or more primitive sewage disposal methods used on camping sites. Mechanisms controlling the adsorption, desorption and transport of viruses in soil/water systems are discussed. Evidence for virus survival in soils and the possibility of predicting virus movement in soils is also included. Epidemiological evidence was supported by an increasing number of field studies demonstrating the viral contamination of shallow aquifers due to the use of rapid infiltration methods for sewage treatment or disposal. A bibliography of 182 references is included. JF - Viral Pollution of the Environment (edited by G. Berg). CRC Press, Boca Raton AU - Vaughn, J M AU - Landry, E F AD - Brookhaven National Laboratory, Upton, N.Y., U.S.A. Y1 - 1983 PY - 1983 DA - 1983 SP - 163 EP - 210,36662 KW - Viruses (-general-) (see also individ grps below) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13835512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Viral+Pollution+of+the+Environment+%28edited+by+G.+Berg%29.+CRC+Press%2C+Boca+Raton&rft.atitle=Viruses+in+soils+and+groundwaters&rft.au=Vaughn%2C+J+M%3BLandry%2C+E+F&rft.aulast=Vaughn&rft.aufirst=J&rft.date=1983-01-01&rft.volume=&rft.issue=&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Viral+Pollution+of+the+Environment+%28edited+by+G.+Berg%29.+CRC+Press%2C+Boca+Raton&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - A technique for estimating phytoplankton division rates by using a DNA-binding fluorescent dye1 AN - 1808732419; PQ0003338933 AB - Phytoplankton division rates were estimated by following time-course changes in DNA using a DNA-specific fluorescent dye. The method is simple, inexpensive, and rapid. A technique using a light bottle minus dark bottle method is described for estimating division rates of phytoplankton samples in natural waters. JF - Limnology and Oceanography AU - Falkowski, Paul G AU - Owens, Thomas G AD - Oceanographic Sciences Division Department of Energy and Environment Brookhaven National Laboratory Upton, New York 11973. Y1 - 1982/07// PY - 1982 DA - July 1982 SP - 776 EP - 782 PB - Association for the Sciences of Limnology and Oceanography VL - 27 IS - 4 SN - 0024-3590, 0024-3590 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Plankton surveys KW - Estimating KW - Limnology KW - Phytoplankton KW - Oceanography KW - Light effects KW - Methodology KW - Natural Waters KW - DNA KW - Fluorescent indicators KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q1 08481:Productivity KW - N 14810:Methods KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808732419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=A+technique+for+estimating+phytoplankton+division+rates+by+using+a+DNA-binding+fluorescent+dye1&rft.au=Falkowski%2C+Paul+G%3BOwens%2C+Thomas+G&rft.aulast=Falkowski&rft.aufirst=Paul&rft.date=1982-07-01&rft.volume=27&rft.issue=4&rft.spage=776&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1982.27.4.0776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Plankton surveys; DNA; Phytoplankton; Methodology; Fluorescent indicators; Light effects; Natural Waters; Estimating; Limnology; Oceanography; Marine DO - http://dx.doi.org/10.4319/lo.1982.27.4.0776 ER - TY - JOUR T1 - Phytoplankton photosynthesis and carbon-specific growth: Light-saturated rates in a nutrient-rich environment 1 AN - 1827896132; PQ0003642130 AB - Light-saturated photosynthesis from short term (2 h) and daily (24 h) measurements were correlated in phytoplankton of two size fractions, net plankton dominated by diatoms and nanoplankton dominated by chlorophytes. Diurnal variations in short term photosynthesis were characterized by a midday maximum and tended to be of a greater amplitude in net plankton than in nanoplankton populations. Nanoplankton photosynthesis varied on a seasonal scale while net plankton photosynthesis varied on a daily scale-a phenomenon which appeared to be reflected in the relationship between short term photosynthesis and growth. The latter, calculated from daily photosynthesis, increased exponentially with temperature and was more closely coupled to short term photosynthesis in nanoplankton than in net plankton populations. These differences seem to be related to the way in which the two size fractions are distributed in time and space as a consequence of interactions between physical process and time-dependent growth. JF - Limnology and Oceanography AU - Malone, Thomas C AD - Oceanographic Sciences Division, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1982/03// PY - 1982 DA - March 1982 SP - 226 EP - 235 PB - Association for the Sciences of Limnology and Oceanography VL - 27 IS - 2 SN - 0024-3590, 0024-3590 KW - Ecology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Chlorophylls KW - Photosynthesis KW - Bacillariophyceae KW - Limnology KW - Diatoms KW - Phytoplankton KW - Growth KW - Temperature effects KW - Growth rate KW - Marine KW - Plankton surveys KW - Diurnal variations KW - Temperature KW - Dominant species KW - Nutrients (mineral) KW - Plankton KW - AQ 00001:Water Resources and Supplies KW - Q1 08563:Fishing gear and methods KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827896132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Phytoplankton+photosynthesis+and+carbon-specific+growth%3A+Light-saturated+rates+in+a+nutrient-rich+environment+1&rft.au=Malone%2C+Thomas+C&rft.aulast=Malone&rft.aufirst=Thomas&rft.date=1982-03-01&rft.volume=27&rft.issue=2&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1982.27.2.0226 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Growth rate; Diurnal variations; Chlorophylls; Plankton surveys; Dominant species; Growth; Photosynthesis; Phytoplankton; Nutrients (mineral); Temperature effects; Diatoms; Plankton; Temperature; Limnology; Bacillariophyceae; Marine DO - http://dx.doi.org/10.4319/lo.1982.27.2.0226 ER - TY - JOUR T1 - Effects of acid precipitation AN - 1529791265; 2014-035449 JF - Environmental Science & Technology, ES & T AU - Glass, Norman R AU - Arnold, Dean E AU - Galloway, James N AU - Hendrey, George R AU - Lee, Jeffrey J AU - McFee, William W AU - Norton, Stephen A AU - Powers, Charles F AU - Rambo, Danny L AU - Schofield, Carl L Y1 - 1982/03// PY - 1982 DA - March 1982 SP - 162A EP - 169A PB - American Chemical Society, Washington, DC VL - 16 IS - 3 SN - 0013-936X, 0013-936X KW - United States KW - sulfur dioxide KW - North America KW - surface water KW - pollution KW - Appalachians KW - mapping KW - ecosystems KW - Eastern U.S. KW - atmospheric precipitation KW - environmental effects KW - air pollution KW - acid rain KW - New York KW - sedimentary rocks KW - soil pollution KW - sensitivity analysis KW - coal KW - alkalinity KW - leaching KW - water pollution KW - Adirondack Mountains KW - rain KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1529791265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Effects+of+acid+precipitation&rft.au=Glass%2C+Norman+R%3BArnold%2C+Dean+E%3BGalloway%2C+James+N%3BHendrey%2C+George+R%3BLee%2C+Jeffrey+J%3BMcFee%2C+William+W%3BNorton%2C+Stephen+A%3BPowers%2C+Charles+F%3BRambo%2C+Danny+L%3BSchofield%2C+Carl+L&rft.aulast=Glass&rft.aufirst=Norman&rft.date=1982-03-01&rft.volume=16&rft.issue=3&rft.spage=162A&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/ L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2014-01-01 N1 - Number of references - 23 N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2014-05-29 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - acid rain; Adirondack Mountains; air pollution; alkalinity; Appalachians; atmospheric precipitation; coal; Eastern U.S.; ecosystems; environmental effects; leaching; mapping; New York; North America; pollution; rain; sedimentary rocks; sensitivity analysis; soil pollution; sulfur dioxide; surface water; United States; water pollution ER - TY - JOUR T1 - Thermoluminescence and optical bleaching in minerals exhibiting second order kinetics and other charge retrapping characteristics AN - 50898043; 2003-003915 JF - PACT (Strasbourg) AU - Levy, Paul W AU - Hackens, Tony AU - Colyn, Philippe AU - Moucharte, Ghislaine Y1 - 1982 PY - 1982 DA - 1982 SP - 224 EP - 242 PB - Conseil de l'Europe, Strasbourg VL - 6 SN - 0257-8727, 0257-8727 KW - silicates KW - plagioclase KW - irradiation KW - albite KW - thermoluminescence KW - electrical charge KW - glow KW - electron traps KW - temperature KW - measurement KW - emission spectra KW - marine sediments KW - sediments KW - optical bleaching KW - framework silicates KW - spectra KW - kinetics KW - feldspar group KW - minerals KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50898043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PACT+%28Strasbourg%29&rft.atitle=Thermoluminescence+and+optical+bleaching+in+minerals+exhibiting+second+order+kinetics+and+other+charge+retrapping+characteristics&rft.au=Levy%2C+Paul+W%3BHackens%2C+Tony%3BColyn%2C+Philippe%3BMoucharte%2C+Ghislaine&rft.aulast=Levy&rft.aufirst=Paul&rft.date=1982-01-01&rft.volume=6&rft.issue=&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=PACT+%28Strasbourg%29&rft.issn=02578727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Second specialist seminar on Thermoluminescence dating N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 12 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - albite; electrical charge; electron traps; emission spectra; feldspar group; framework silicates; glow; irradiation; kinetics; marine sediments; measurement; minerals; optical bleaching; plagioclase; sediments; silicates; spectra; temperature; thermoluminescence ER - TY - JOUR T1 - Radon and thoron emanation measurements and the effects of ground water AN - 50896194; 2003-003902 JF - PACT (Strasbourg) AU - Carriveau, Gary W AU - Harbottle, Garman AU - Hackens, Tony AU - Colyn, Philippe AU - Moucharte, Ghislaine Y1 - 1982 PY - 1982 DA - 1982 SP - 145 EP - 154 PB - Conseil de l'Europe, Strasbourg VL - 6 SN - 0257-8727, 0257-8727 KW - dosimetry KW - concentration KW - alkaline earth metals KW - radium KW - isotopes KW - Th-234 KW - radon KW - Rn-222 KW - measurement KW - ground water KW - Ra-226 KW - radon emanometry KW - radioactive isotopes KW - gamma rays KW - noble gases KW - metals KW - thorium KW - corrections KW - actinides KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50896194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PACT+%28Strasbourg%29&rft.atitle=Radon+and+thoron+emanation+measurements+and+the+effects+of+ground+water&rft.au=Carriveau%2C+Gary+W%3BHarbottle%2C+Garman%3BHackens%2C+Tony%3BColyn%2C+Philippe%3BMoucharte%2C+Ghislaine&rft.aulast=Carriveau&rft.aufirst=Gary&rft.date=1982-01-01&rft.volume=6&rft.issue=&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=PACT+%28Strasbourg%29&rft.issn=02578727&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Second specialist seminar on Thermoluminescence dating N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 16 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - actinides; alkaline earth metals; concentration; corrections; dosimetry; gamma rays; ground water; isotopes; measurement; metals; noble gases; Ra-226; radioactive isotopes; radium; radon; radon emanometry; Rn-222; Th-234; thorium ER - TY - JOUR T1 - Effects of polycyclic aromatic hydrocarbons on the proliferation of ectopic thyroid tissue in Poecilia formosa, the Amazon molly AN - 13884823; S198206794 AB - Intraperitoneal injection of young Amazon mollies with various polycyclic aromatic hydrocarbons was found to cause massive enlargement of the spleen; this was due to spleen tissue being wholly or partly replaced by proliferating thyroid tissue . JF - Journal of Fish Biology AU - Woodhead, AD AU - Setlow, R B AU - Pond, V AD - Brookhaven National Laboratory, N.Y. Y1 - 1982 PY - 1982 DA - 1982 SP - 455 EP - 463 VL - 20 IS - 4 SN - 0022-1112, 0022-1112 KW - Jn - j. fish biol. KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13884823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Fish+Biology&rft.atitle=Effects+of+polycyclic+aromatic+hydrocarbons+on+the+proliferation+of+ectopic+thyroid+tissue+in+Poecilia+formosa%2C+the+Amazon+molly&rft.au=Woodhead%2C+AD%3BSetlow%2C+R+B%3BPond%2C+V&rft.aulast=Woodhead&rft.aufirst=AD&rft.date=1982-01-01&rft.volume=20&rft.issue=4&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Journal+of+Fish+Biology&rft.issn=00221112&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Concentrations of some ionic species in central Long Island, New York , precipitation in relation to meteorological variables AN - 13882553; S198206713 AB - Data on the concentrations of major anions and cations in atmospheric precipitation over central Long Island, N.Y. , over a 3-year period were analysed to determine the relation between the various ions and their relations to meteorological conditions. Results for sulphate, nitrate plus nitrite, ammonia, chloride, and sodium are discussed. JF - Water, Air, & Soil Pollution AU - Raynor, G S AU - Hayes, J V AD - Brookhaven National Laboratory, N.Y. Y1 - 1982 PY - 1982 DA - 1982 SP - 309 EP - 335 VL - 17 IS - 3 SN - 0049-6979, 0049-6979 KW - Analysis KW - Jn - water, air and soil pollution KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13882553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Concentrations+of+some+ionic+species+in+central+Long+Island%2C+New+York+%2C+precipitation+in+relation+to+meteorological+variables&rft.au=Raynor%2C+G+S%3BHayes%2C+J+V&rft.aulast=Raynor&rft.aufirst=G&rft.date=1982-01-01&rft.volume=17&rft.issue=3&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Phytoplankton photosynthesis and carbon-specific growth: light-saturated rates in a nutrient-rich environment AN - 13881244; 198202114 AB - Tabulated and graphical results are given from studies on photosynthesis in marine phytoplankton of two different size fractions (net plankton dominated by diatoms and nannoplankton dominated by chlorophytes), saturated with light . Differences in photosynthesis and growth rate between the two size fractions are discussed and attributed to the way in which they are distributed in time and space. JF - Limnology and Oceanography AU - Malone, T C AD - Brookhaven National Laboratory, N.Y. Y1 - 1982 PY - 1982 DA - 1982 SP - 226 EP - 235 VL - 27 IS - 2 SN - 0024-3590, 0024-3590 KW - Light KW - Jn - limnol. oceanogr. KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13881244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Phytoplankton+photosynthesis+and+carbon-specific+growth%3A+light-saturated+rates+in+a+nutrient-rich+environment&rft.au=Malone%2C+T+C&rft.aulast=Malone&rft.aufirst=T&rft.date=1982-01-01&rft.volume=27&rft.issue=2&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Laboratory study of sulfuric acid spill characteristics pertaining to maritime accidents AN - 13878800; S198308486 AB - Several marine acid-spill accidents are hypothesized and laboratory experiments are described which simulated two different types, convective mixing of concentrated sulphuric acid with water and instantaneous surface spills of oleum. A mathematical model was developed to describe the first type and it is shown that the buoyancy force arising from changing acid concentration and the heat of dilution are the main factors governing dispersion . In the case of oleum spills dense clouds of acid aerosols have been formed which are well within the respirable particle size range. The fraction of airborne acid, however, decreases rapidly with increasing depth of release below the surface. The difference in scale between these experiments and actual marine spills emphasize the need for field trials. JF - Environmental Science & Technology AU - Tang, IN AU - Wong, W T AU - Munkelwitz, H R AU - Flessner, M F AD - Brookhaven National Laboratory, N.Y. Y1 - 1982 PY - 1982 DA - 1982 SP - 587 EP - 593 VL - 16 IS - 9 SN - 0013-936X, 0013-936X KW - Laboratory studies KW - Modelling (-general-) KW - Reduction KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13878800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Laboratory+study+of+sulfuric+acid+spill+characteristics+pertaining+to+maritime+accidents&rft.au=Tang%2C+IN%3BWong%2C+W+T%3BMunkelwitz%2C+H+R%3BFlessner%2C+M+F&rft.aulast=Tang&rft.aufirst=IN&rft.date=1982-01-01&rft.volume=16&rft.issue=9&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Inefficient accumulation of low levels of monodisposed and faeces-associated poliovirus in oysters AN - 13875884; S198308804 AB - Studies on the uptake of poliovirus by oysters (Crassostrea virginica or Crassostrea gigas) and clams (Mercenaria mercenaria) showed that virus was accumulated by the shellfish only when the virus concentration in the water exceeded 0.01 PFU per ml. At high concentrations of virus, accumulation increased with increasing concentration, for both dispersed and faeces-associated virus. JF - Applied and Environmental Microbiology AU - Landry, E F AU - Vaughn, J M AU - Vicale, T J AU - Mann, R AD - Brookhaven National Laboratory,N.Y. Y1 - 1982 PY - 1982 DA - 1982 SP - 1362 EP - 1369 VL - 44 IS - 6 SN - 0099-2240, 0099-2240 KW - Viruses (-general-) (see also individ grps below) KW - Aqualine Abstracts KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13875884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Inefficient+accumulation+of+low+levels+of+monodisposed+and+faeces-associated+poliovirus+in+oysters&rft.au=Landry%2C+E+F%3BVaughn%2C+J+M%3BVicale%2C+T+J%3BMann%2C+R&rft.aulast=Landry&rft.aufirst=E&rft.date=1982-01-01&rft.volume=44&rft.issue=6&rft.spage=1362&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Structure of magnetite (Fe (sub 3) O (sub 4) ) below the Verwey transition temperature AN - 1124739397; 2012-093860 AB - The structure of Fe (sub 3) O (sub 4) at 10 K, a T below that of the Verwey transition (T (sub V) approx 120 K), has been analysed with three-dimensional neutron diffraction data. The space group is found to be Cc with a monoclinic unit cell which corresponds with sq root 2a X sq root 2a X 2a of the cubic spinel unit cell (space group Fd3m) found above T (sub V) . The monoclinic unit cell contains 32 formula units. In order to facilitate analysis of this complicated structure, primitive orthorhombic space groups with pseudosymmetric elements have been adopted as approximations. The displacements of atoms from the cubic positions have been decomposed into distinct displacement patterns with characteristic symmetries, which suggest that the displacements brought about by the phase transition result from the simultaneous condensation of a few phonons. (Authors' abstract) JF - Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry AU - Iizumi, M AU - Koetzle, T F AU - Shirane, G AU - Chikazumi, S AU - Matsui, M AU - Todo, S Y1 - 1982 PY - 1982 DA - 1982 SP - 2121 EP - 2133 PB - Wiley Interscience for International Union of Crystallography, Copenhagen VL - B38 IS - 8 SN - 0567-7408, 0567-7408 KW - Verwey transition KW - refinement KW - lattice KW - crystal systems KW - space groups KW - unit cell KW - spinel KW - crystal structure KW - temperature KW - phonons KW - neutron diffraction data KW - oxides KW - monoclinic system KW - symmetry KW - transformations KW - magnetite KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1124739397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica%2C+Section+B%3A+Structural+Crystallography+and+Crystal+Chemistry&rft.atitle=Structure+of+magnetite+%28Fe+%28sub+3%29+O+%28sub+4%29+%29+below+the+Verwey+transition+temperature&rft.au=Iizumi%2C+M%3BKoetzle%2C+T+F%3BShirane%2C+G%3BChikazumi%2C+S%3BMatsui%2C+M%3BTodo%2C+S&rft.aulast=Iizumi&rft.aufirst=M&rft.date=1982-01-01&rft.volume=B38&rft.issue=8&rft.spage=2121&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica%2C+Section+B%3A+Structural+Crystallography+and+Crystal+Chemistry&rft.issn=05677408&rft_id=info:doi/10.1107%2FS0567740882008176 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 2012-01-01 N1 - Number of references - 32 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-11-01 N1 - SubjectsTermNotLitGenreText - crystal structure; crystal systems; lattice; magnetite; monoclinic system; neutron diffraction data; oxides; phonons; refinement; space groups; spinel; symmetry; temperature; transformations; unit cell; Verwey transition DO - http://dx.doi.org/10.1107/S0567740882008176 ER - TY - JOUR T1 - Lead in the marine environment; book review AN - 52612711; 1998-029563 JF - Organic Geochemistry AU - Premuzic, Eugene T Y1 - 1981/04// PY - 1981 DA - April 1981 SP - 57 EP - 56 PB - Pergamon, Oxford-New York VL - 3 IS - 1-2 SN - 0146-6380, 0146-6380 KW - sea water KW - metals KW - biochemistry KW - pollution KW - lead KW - geochemistry KW - book reviews KW - bioaccumulation KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52612711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+Geochemistry&rft.atitle=Lead+in+the+marine+environment%3B+book+review&rft.au=Premuzic%2C+Eugene+T&rft.aulast=Premuzic&rft.aufirst=Eugene&rft.date=1981-04-01&rft.volume=3&rft.issue=1-2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Organic+Geochemistry&rft.issn=01466380&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/01466380 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1998-01-01 N1 - SuppNotes - Edited by Branica, Marko and Konrad, Zdenka, Pergamon Press, 1980 N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bioaccumulation; biochemistry; book reviews; geochemistry; lead; metals; pollution; sea water ER - TY - BOOK T1 - Effects of acidic precipitation and acidity on soil microbial processes AN - 13868424; S198309219 AB - The effects of soil acidity on the microbial decomposition of organic matter and transformation of nitrogen in acid forest soils were investigated. Samples of air-dried forest soil were adjusted to pH 3.0 or 7.0 by the addition of sulphuric acid or calcium hydroxide, and incubated in the dark at room temperature in the presence of leaf tissue and specific organic compounds. Rates of carbon dioxide production, ammonification and nitrification were observed and the numbers of nitrogen-fixing bacteria determined. The results suggest that further acidification of acid forest soils will significantly reduce the extent of leaf litter decomposition and nitrogen mineralization processes, thus reducing the extent of nutrient cycling in the forest ecosystem. JF - U.S. National Technical Information Service. Springfield, Va., Report CONF 810493-1, (35164) AU - Francis, A J Y1 - 1981/04// PY - 1981 DA - Apr 1981 SP - 1 EP - 35 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13868424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Francis%2C+A+J&rft.aulast=Francis&rft.aufirst=A&rft.date=1981-04-01&rft.volume=&rft.issue=&rft.spage=35&rft.isbn=&rft.btitle=Effects+of+acidic+precipitation+and+acidity+on+soil+microbial+processes&rft.title=Effects+of+acidic+precipitation+and+acidity+on+soil+microbial+processes&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Acidity and conductivity of precipitation on central Long Island, New York , in relation to meteorological variables AN - 13895873; S198103131 AB - Tabulated data are given on variations in acidity and conductivity of rainwater collected hourly in Long Island, N.Y. , over a three-year period, in relation to variations in meteorological conditions. JF - Water, Air, & Soil Pollution AU - Raynor, G S AU - Hayes, J V AD - BROOKHAVEN NATIONAL LABORATORY Y1 - 1981 PY - 1981 DA - 1981 SP - 229 EP - 245 VL - 15 IS - 2 SN - 0049-6979, 0049-6979 KW - Jn - water, air and soil pollution KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13895873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Acidity+and+conductivity+of+precipitation+on+central+Long+Island%2C+New+York+%2C+in+relation+to+meteorological+variables&rft.au=Raynor%2C+G+S%3BHayes%2C+J+V&rft.aulast=Raynor&rft.aufirst=G&rft.date=1981-01-01&rft.volume=15&rft.issue=2&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Acidic precipitation: Considerations for an air quality standard AN - 13889370; S198205934 AB - The effects of acidic precipitation on agricultural and forest systems in southern Scandinavia, southwestern Scotland, southwestern Canada and northeastern U.S.A. are discussed. Nitrate and sulphate are the principal anions accounting for the hydrogen ion concentration and the nutrition benefits of these ions are considered. It is indicated that a maximum permissible level for the volume weighted annual hydrogen ion concentration of 25 ueq per litre would protect fresh waters from acidification, and, possibly, other systems. JF - Water, Air, & Soil Pollution AU - Evans, L S AU - Hendrey, G R AU - Stensland, G J AU - Johnson, D W AU - Francis, A J AD - Brookhaven National Laboratory Y1 - 1981 PY - 1981 DA - 1981 SP - 469 EP - 509 VL - 16 IS - 4 SN - 0049-6979, 0049-6979 KW - Jn - water, air and soil pollution KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13889370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Acidic+precipitation%3A+Considerations+for+an+air+quality+standard&rft.au=Evans%2C+L+S%3BHendrey%2C+G+R%3BStensland%2C+G+J%3BJohnson%2C+D+W%3BFrancis%2C+A+J&rft.aulast=Evans&rft.aufirst=L&rft.date=1981-01-01&rft.volume=16&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Rapid, quantitative separation of chlorophylls and their degradation products by high-performance liquid chromatography AN - 13887915; 198103466 AB - The authors present a rapid and sensitive high-performance liquid chromatography system which supplements the simple fluorometric method, for determining the major chlorophylls and their degradation products, including chlorophylls a, b, and c, chlorophyllide a, phaeophorbide a, and phaeophytins a and b. JF - Journal of Chromatography AU - Falkowski, P G AU - Sucher, J AD - Brookhaven National Laboratory Y1 - 1981 PY - 1981 DA - 1981 SP - 349 EP - 351 VL - 213 IS - 2 SN - 0021-9673, 0021-9673 KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13887915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography&rft.atitle=Rapid%2C+quantitative+separation+of+chlorophylls+and+their+degradation+products+by+high-performance+liquid+chromatography&rft.au=Falkowski%2C+P+G%3BSucher%2C+J&rft.aulast=Falkowski&rft.aufirst=P&rft.date=1981-01-01&rft.volume=213&rft.issue=2&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography&rft.issn=00219673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Rocks, soils , and water quality. Relationships and implications for effects of acid precipitation on surface water in the northeastern United States AN - 13887433; 198102670 AB - The effect of rocks and soils in the northeastern U.S.A. on the pH value and alkalinity of surface water was investigated, and the results were used to develop two mathematical models to describe the importance of rocks and soils on water quality and on the sensitivity of surface waters to acidification by acid precipitation. JF - Environmental Science & Technology AU - Kaplan, E AU - Thode, H C AU - Protas, A AD - Brookhaven National Laboratory, N.Y. Y1 - 1981 PY - 1981 DA - 1981 SP - 539 EP - 544 VL - 15 IS - 5 SN - 0013-936X, 0013-936X KW - Modelling (-general-) KW - Surface water (s/a lakes,ponds,reservoirs,streams) KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13887433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Rocks%2C+soils+%2C+and+water+quality.+Relationships+and+implications+for+effects+of+acid+precipitation+on+surface+water+in+the+northeastern+United+States&rft.au=Kaplan%2C+E%3BThode%2C+H+C%3BProtas%2C+A&rft.aulast=Kaplan&rft.aufirst=E&rft.date=1981-01-01&rft.volume=15&rft.issue=5&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Effects of acidification on aquatic primary producers and decomposers AN - 13870522; S198310015 AB - The nature of the changes in the aquatic ecosystem consequent on the acidification of nutrient-poor clearwater lakes and streams is discussed. While acidification may eliminate fish, the lake is not killed since some species become very abundant in acidified waters, while the normal balance of the biocoenosis is disturbed. The effects of acidity on macrophytes, algae (including attached and filamentous algae) and phytoplankton are discussed, together with the process of decomposition of plant matter. Since liming accelerates the decomposition of plant debris, the clarity and dissolved oxygen consumption and productivity in the lake water may also increase. JF - Acid Rain/Fisheries: Proceedings of International Symposium. Cornell University, Bethesda, Md, 1982, 125-135. (15Aa HAI) AU - Hendrey, G R AD - Brookhaven National Laboratory, N.Y. Y1 - 1981 PY - 1981 DA - 1981 VL - (edited-by T. A. Haines and R. E. Johnson) KW - Algae (see also individual groups below) KW - Fish (see also individual groups listed below) KW - Lime treatment KW - Plants (see also aquatic macrophytes, grps below) KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13870522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acid+Rain%2FFisheries%3A+Proceedings+of+International+Symposium.+Cornell+University%2C+Bethesda%2C+Md%2C+1982%2C+125-135.+%2815Aa+HAI%29&rft.atitle=Effects+of+acidification+on+aquatic+primary+producers+and+decomposers&rft.au=Hendrey%2C+G+R&rft.aulast=Hendrey&rft.aufirst=G&rft.date=1981-01-01&rft.volume=%28edited-by+T.+A.+Haines+and+R.+E.+Johnson%29&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Acid+Rain%2FFisheries%3A+Proceedings+of+International+Symposium.+Cornell+University%2C+Bethesda%2C+Md%2C+1982%2C+125-135.+%2815Aa+HAI%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Microbial Activity of Trench Leachates from Shallow-Land, Low-Level Radioactive Waste Disposal Sites AN - 19247090; 8203261 AB - The abundance, distribution, and growth of microorganisms in waste leachates containing a variety of radionuclides and organics are described so as to begin to evaluate the role of microorganisms in the transformation of radioactive wastes. Water samples were collected from trenches at the disposal sites of Maxey Flats, Kentucky; West Valley, New York; Sheffield, Illinois; and Barnwell, South Carolina. Among the several aerobic and anaerobic bacteria isolated, only Bacillus sp., Pseudomonas sp., Citrobacter sp., and Clostridium sp. were identified. Mixed bacterial cultures isolated from the trench leachates were able to grow anaerobically in trench leachates, which indicates that the radionuclides and organic chemicals present were not toxic to these bacteria. Changes in concentrations of several of the organic constituents of the waste leachate samples were observed due to anaerobic microbial activity. Growth of a mixed culture of trench-water bacteria in media containing a mixture of radionuclides, Co-60, Sr-85, and Cs-134/137, was not affected at total activity concentrations of 260 and 2700 pCi/ml. The finding of active microflora in the trench leachates strongly suggests that they may play a significant role in the transformation of radionuclides and the organic constituents of the waste and thus affect the long-term storage, mobility, and migration of radionuclides from the waste disposal sites into the biosphere. (Baker-FRC) JF - Applied and Environmental Microbiology Vol 40, No 1, p 108-113, July, 1980. 2 Fig, 5 Tab, 12 Ref. AU - Francis, A J AU - Dobbs, S AU - Nine, B J AD - Brookhaven National Laboratory Upton, NY Y1 - 1980/07// PY - 1980 DA - Jul 1980 KW - Water Resources Abstracts KW - Radioactive wastes KW - Microorganisms KW - Leachates KW - Microbial degradation KW - Degradation KW - Bacteria KW - Methane bacteria KW - Denitrification KW - Anaerobic conditions KW - Aerobic bacteria KW - Bacillus KW - Pseudomonas KW - Citrobacter KW - Clostridium KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19247090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=Microbial+Activity+of+Trench+Leachates+from+Shallow-Land%2C+Low-Level+Radioactive+Waste+Disposal+Sites&rft.au=Francis%2C+A+J%3BDobbs%2C+S%3BNine%2C+B+J&rft.aulast=Francis&rft.aufirst=A&rft.date=1980-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Natural feeding rates of Centropages typicus females in the New York Bight 1 AN - 1808649475; PQ0003338757 AB - Based on measurements of the removal rate of small particles from natural seawater, the ingestion rate of adult females of the copepod Centropages typicus is almost always less than maximal. A survey of particle concentrations in the New York Bight indicated that the concentrations used in our feeding experiments were representative of concentrations encountered by this species. In addition to the particle removal method, a gut fluorescence method was used to calculate natural ingestion rates of phytoplankton particles. Comparable rates resulted from both methods. We believe that for this organism, ingestion rates are closely related to food quality because the range of natural food concentrations is rather narrow. JF - Limnology and Oceanography AU - Dagg, MJ AU - Grill, D W AD - Oceanographic Sciences Division, Department of Energy and Environment, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1980/07// PY - 1980 DA - July 1980 SP - 597 EP - 609 PB - Association for the Sciences of Limnology and Oceanography VL - 25 IS - 4 SN - 0024-3590, 0024-3590 KW - Ecology Abstracts; Animal Behavior Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Limnology KW - Phytoplankton KW - Feeding behaviour KW - Marine environment KW - Copepoda KW - Centropages typicus KW - Feeding Rates KW - Food quality KW - Crustaceans (copepod) KW - Marine KW - Feeding KW - Particle concentration KW - Fluorescence KW - Bights KW - Surveys KW - Oceanography KW - ANW, USA, New York Bight KW - Methodology KW - Foods KW - Sea water KW - Digestive tract KW - Feeding experiments KW - Females KW - AQ 00001:Water Resources and Supplies KW - Y 25150:General/Miscellaneous KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808649475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Natural+feeding+rates+of+Centropages+typicus+females+in+the+New+York+Bight+1&rft.au=Dagg%2C+MJ%3BGrill%2C+D+W&rft.aulast=Dagg&rft.aufirst=MJ&rft.date=1980-07-01&rft.volume=25&rft.issue=4&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1980.25.4.0597 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Sea water; Particle concentration; Feeding behaviour; Feeding experiments; Phytoplankton; Females; Methodology; Feeding; Fluorescence; Digestive tract; Marine environment; Food quality; Crustaceans (copepod); Foods; Bights; Surveys; Limnology; Feeding Rates; Oceanography; Copepoda; Centropages typicus; ANW, USA, New York Bight; Marine DO - http://dx.doi.org/10.4319/lo.1980.25.4.0597 ER - TY - JOUR T1 - An analysis of factors affecting oxygen depletion in the New York Bight AN - 13895400; 198100152 AB - Anoxic conditions have developed in the New York Bight off New Jersey, reflected by a loss to the shellfish industry. The anoxia was attributed to increased anthropogenic carbon loading from urban areas adjacent to the Bight, climatically restricted renewal of oxygen to the bottom waters, and the abundance (and hence respiratory demands) of the dinoflagellate, Ceratium tripos, beneath the pycnocline. Between 1966 and 1976, the causal chain of events leading to the anoxia were as follows: a warm winter in 1976 with large run-off, a low frequency of spring storm events, a deep summer thermocline, persistent southerly winds with few reversals, a large autochthonous carbon load (Ceratium tripos) and low grazing pressure by zooplankton. The anoxia could have occurred in the summer of 1976 without any carbon loading from New York City. Anoxia from this open shelf system may have resulted from natural physical forcing and a biological response. JF - Journal of Marine Research AU - Falkowski, P G AU - Hopkins, T S AU - Walsh, J J AD - Brookhaven National Laboratory, Upton, N.Y. Y1 - 1980 PY - 1980 DA - 1980 SP - 479 EP - 506 VL - 38 IS - 3 SN - 0022-2402, 0022-2402 KW - Wind KW - Aqualine Abstracts KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13895400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Marine+Research&rft.atitle=An+analysis+of+factors+affecting+oxygen+depletion+in+the+New+York+Bight&rft.au=Falkowski%2C+P+G%3BHopkins%2C+T+S%3BWalsh%2C+J+J&rft.aulast=Falkowski&rft.aufirst=P&rft.date=1980-01-01&rft.volume=38&rft.issue=3&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Journal+of+Marine+Research&rft.issn=00222402&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - BOOK T1 - Data report : the fate of human enteric viruses in a natural sewage recirculating system AN - 13890414; 198103814 AB - A two-year study was performed to estimate the virus-removing capabilities of two pilot-scale wetland ecosystems for the treatment of screened, raw, non-settled sewage. One system consisted of two meadows in series with a marsh/pond sequence, while the second system was composed of several marsh/pond units . The systems were operated continuously throughout the year at daily application rates from 420 to 835 m2 per ha. Both systems demonstrated moderate virus removal capability with the marsh/pond system giving the most consistent results, the reduction apparently occurring principally in the marsh component. As an aid to the monitoring of system performance, improved techniques for the concentration and enumeration of human viruses from sewage-contaminated aquatic environments were developed. JF - U.S. Department of Energy and the Environment. Brookhaven National Laboratory Report BNL 51281, (07G VAU) AU - Vaughn, J M AU - Landry, E F Y1 - 1980 PY - 1980 DA - 1980 SP - 1 EP - 52 KW - Viruses (-general-) (see also individ grps below) KW - Aqualine Abstracts KW - AQ 00006:Sewage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13890414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Vaughn%2C+J+M%3BLandry%2C+E+F&rft.aulast=Vaughn&rft.aufirst=J&rft.date=1980-01-01&rft.volume=&rft.issue=&rft.spage=52&rft.isbn=&rft.btitle=Data+report+%3A+the+fate+of+human+enteric+viruses+in+a+natural+sewage+recirculating+system&rft.title=Data+report+%3A+the+fate+of+human+enteric+viruses+in+a+natural+sewage+recirculating+system&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Recent radiation-effect studies on natural and synthetic rock salt for waste-disposal applications AN - 51057625; 1997-006947 JF - ONWI (Battelle Memorial Institute, Office of Nuclear Waste-Isolation) AU - Swyler, K J AU - Klaffky, R W AU - Levy, P W AU - Anonymous Y1 - 1979/10// PY - 1979 DA - October 1979 SP - 52 EP - 53 PB - Battelle Memorial Institute, Office of Nuclear Waste-Isolation, [Columbus, OH] SN - 0730-2800, 0730-2800 KW - halides KW - high-level waste KW - experimental studies KW - chemically precipitated rocks KW - radiation damage KW - evaporites KW - halite KW - radioactive waste KW - laboratory studies KW - sedimentary rocks KW - gamma rays KW - chlorides KW - waste disposal KW - synthetic materials KW - salt KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51057625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ONWI+%28Battelle+Memorial+Institute%2C+Office+of+Nuclear+Waste-Isolation%29&rft.atitle=Recent+radiation-effect+studies+on+natural+and+synthetic+rock+salt+for+waste-disposal+applications&rft.au=Swyler%2C+K+J%3BKlaffky%2C+R+W%3BLevy%2C+P+W%3BAnonymous&rft.aulast=Swyler&rft.aufirst=K&rft.date=1979-10-01&rft.volume=&rft.issue=&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=ONWI+%28Battelle+Memorial+Institute%2C+Office+of+Nuclear+Waste-Isolation%29&rft.issn=07302800&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - National Waste Terminal Storage Program information meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1997-01-01 N1 - Number of references - 4 N1 - PubXState - OH] N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - chemically precipitated rocks; chlorides; evaporites; experimental studies; gamma rays; halides; halite; high-level waste; laboratory studies; radiation damage; radioactive waste; salt; sedimentary rocks; synthetic materials; waste disposal ER - TY - JOUR T1 - Mortality, Migration, Income and Air Pollution: A Comparative Study AN - 61097015; 82M6494 AB - The interrelationships among different demographic factors, specific causes of death, median family income, & estimated air pollution emissions are examined. Using the Medical Data Base (MEDABA) developed at Brookhaven National Laboratory (Long Island, NY), the entire population of the US was cross-tabulated by income & emission levels of air pollutants. Path analysis was used to examine a number of patterns & relationships for each age, race, & sex group containing a minimum of 10,000 persons. Competitive & complementary effects are observed. These effects are frequently age dependent & occasionally sex related. This specialized data base, the application of path analysis, & the development of a dynamic population & mortality model, in combination, proved to be a useful tool for investigating the effects of energy related pollutants on the exposed population. 12 Tables, 11 Figures. HA. JF - Social Science and Medicine AU - Boozo, S R AU - Novak, K M AU - Galdos, F AU - Hakoopian, R AU - Hamilton, L D AD - National Center Analysis Energy Systems Brookhaven National Laboratory, Upton Long Island NY 11973 Y1 - 1979/06// PY - 1979 DA - June 1979 SP - 95 EP - 109 VL - 13D IS - 2 SN - 0277-9536, 0277-9536 KW - mortality, migration KW - income, air pollution KW - Income/Incomes KW - Migration KW - Pollution KW - Mortality (see also Death, Dying) KW - article KW - 1837: demography and human biology; demography (population study) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61097015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=Mortality%2C+Migration%2C+Income+and+Air+Pollution%3A+A+Comparative+Study&rft.au=Boozo%2C+S+R%3BNovak%2C+K+M%3BGaldos%2C+F%3BHakoopian%2C+R%3BHamilton%2C+L+D&rft.aulast=Boozo&rft.aufirst=S&rft.date=1979-06-01&rft.volume=13D&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Mortality (see also Death, Dying); Migration; Income/Incomes; Pollution ER - TY - JOUR T1 - Survey of human enterovirus occurrence in fresh and marine surface waters on Long Island AN - 13927126; 197903973 AB - A year-long survey was made of a variety of surface water systems on Long Island, N.Y. , involving monthly sampling and analyses for indigenous human enteroviruses and coliform bacteria. The results are presented with tables, and discussed in relation to the findings of previous studies. A bibliography of 36 references is appended. JF - Applied and Environmental Microbiology AU - Vaughn, J M AU - Landry, E F AU - Thomas, M Z AU - Vicale, T J AU - Penello, W F AD - BROOKHAVEN NATIONAL LABORATORY, N.Y. Y1 - 1979 PY - 1979 DA - 1979 SP - 290 EP - 296 VL - 38 IS - 2 SN - 0099-2240, 0099-2240 KW - Analysis KW - Surface water (s/a lakes,ponds,reservoirs,streams) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13927126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Survey+of+human+enterovirus+occurrence+in+fresh+and+marine+surface+waters+on+Long+Island&rft.au=Vaughn%2C+J+M%3BLandry%2C+E+F%3BThomas%2C+M+Z%3BVicale%2C+T+J%3BPenello%2C+W+F&rft.aulast=Vaughn&rft.aufirst=J&rft.date=1979-01-01&rft.volume=38&rft.issue=2&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Adsorption of enteroviruses to soil cores and their subsequent elution by artificial rainwater AN - 13906938; 198000418 AB - A study was carried out to determine the virus-binding capacities of Long Island soil, and the extent of virus desorption by rainwater, using cores collected from an operating recharge basin. The results show that a number of polioviruses were efficiently adsorbed to a highly permeable, coarse, sandy soil, while the elution of the viruses by sewage effluent or rainwater rinses appeared to be strain dependent JF - Applied and Environmental Microbiology AU - Landry, E F AU - Vaughn, J M AU - Thomas, M Z AU - Beckwith, CA AD - BROOKHAVEN NATIONAL LABORATORY Y1 - 1979 PY - 1979 DA - 1979 SP - 680 EP - 687 VL - 38 IS - 4 SN - 0099-2240, 0099-2240 KW - Viruses (-general-) (see also individ grps below) KW - Aqualine Abstracts KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13906938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Adsorption+of+enteroviruses+to+soil+cores+and+their+subsequent+elution+by+artificial+rainwater&rft.au=Landry%2C+E+F%3BVaughn%2C+J+M%3BThomas%2C+M+Z%3BBeckwith%2C+CA&rft.aulast=Landry&rft.aufirst=E&rft.date=1979-01-01&rft.volume=38&rft.issue=4&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Wind events and food chain dynamics within the New York Bight 1 , 2 AN - 1808662698; PQ0003338472 AB - Time series of wind, current, nutrients, chlorophyll, and zooplankton are used to examine the effect of storm events on the food chain dynamics of the New York Bight. Storms cause dilution of phytoplankton concentration in the vertical plane, but lead to aggregation of chlorophyll in the horizontal field. Nutrients are made available with onshore flow in response to wind events favorable for upwelling. A series of nutrient budgets suggest that storm-induced mixing and upwelling of nitrate may satisfy at least 33% of the productivity demand of this system. Examples of the biological response to storms are drawn from 20 cruises during January, March, April-May, and August-September 1974, 1975, 1976, and 1977 under mixed and stratified conditions of the water column. The interaction of storms and seasonal stratification suggests predictable structure and frequency of chlorophyll distribution across the shelf which may influence both the survival strategies of herbivores and the loci of energy transfer to the rest of the food chain. JF - Limnology and Oceanography AU - Walsh, John J AU - Whitledge, Terry E AU - Barvenik, Frank W AU - Wirick, Creighton D AU - Howe, Steven O AU - Esaias, Wayne E AU - Scott, Jon T AD - Oceanographic Sciences Division, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1978/07// PY - 1978 DA - July 1978 SP - 659 EP - 683 PB - Association for the Sciences of Limnology and Oceanography VL - 23 IS - 4 SN - 0024-3590, 0024-3590 KW - Animal Behavior Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Nitrate KW - Chlorophylls KW - Chlorophyll KW - Food chains KW - Upwelling KW - Survival KW - Phytoplankton KW - Nutrients KW - Storms KW - Water column KW - Food Chains KW - Wind KW - Marine KW - Plankton surveys KW - Energy Transfer KW - Bights KW - Zooplankton KW - ANW, USA, New York Bight KW - Herbivores KW - Energy transfer KW - AQ 00001:Water Resources and Supplies KW - Y 25150:General/Miscellaneous KW - Q1 08482:Ecosystems and energetics KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808662698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Wind+events+and+food+chain+dynamics+within+the+New+York+Bight+1+%2C+2&rft.au=Walsh%2C+John+J%3BWhitledge%2C+Terry+E%3BBarvenik%2C+Frank+W%3BWirick%2C+Creighton+D%3BHowe%2C+Steven+O%3BEsaias%2C+Wayne+E%3BScott%2C+Jon+T&rft.aulast=Walsh&rft.aufirst=John&rft.date=1978-07-01&rft.volume=23&rft.issue=4&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1978.23.4.0659 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Plankton surveys; Chlorophylls; Herbivores; Food chains; Upwelling; Energy transfer; Phytoplankton; Nitrate; Chlorophyll; Zooplankton; Survival; Nutrients; Water column; Wind; Food Chains; Energy Transfer; Bights; Storms; ANW, USA, New York Bight; Marine DO - http://dx.doi.org/10.4319/lo.1978.23.4.0659 ER - TY - BOOK T1 - Developmen of a glass polymer composite sewer pipe from waste glass. Progress report No.7 AN - 13917692; 197902821 AB - Progress in the evaluation of a polymer concrete sewer pipe incorporating waste glass fragments is reported, based on results of comparative tests with asbestos-cement and vitrified clay pipes. To date no deterioration or other problems have been reported in the course of field tests in progress for up to 6 years, and further tests are to be conducted in a section handling acid waste of pH 24. Increased compressive strengths have been obtained by reduction of the polymer content from 125 to 100 per cent and a comparison of the revised estimates of the energy required for production of this pipe relative to that for vitrified clay pipe indicates savings of between 16 and 40 per cent. JF - U.S. National Technical Information Service. Springfield, Va., Report No. BNL 50835, UC-25, (P 06B KUK) AU - Kukacka, LE AU - Rayfiel, R AU - Fontana, J AU - Arnold, G AU - Galen, B Y1 - 1978/04// PY - 1978 DA - Apr 1978 SP - 1 EP - 17 KW - Pipes (see also conduits, drains, pipelines,sewers) KW - Aqualine Abstracts KW - AQ 00006:Sewage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/13917692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Aqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Kukacka%2C+LE%3BRayfiel%2C+R%3BFontana%2C+J%3BArnold%2C+G%3BGalen%2C+B&rft.aulast=Kukacka&rft.aufirst=LE&rft.date=1978-04-01&rft.volume=&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=Developmen+of+a+glass+polymer+composite+sewer+pipe+from+waste+glass.+Progress+report+No.7&rft.title=Developmen+of+a+glass+polymer+composite+sewer+pipe+from+waste+glass.+Progress+report+No.7&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2000-09-01 N1 - Last updated - 2011-12-12 ER - TY - JOUR T1 - Further transition states of the Baja California upwelling ecosystem 1 , 2 AN - 1808654569; PQ0003338259 AB - Measurements were made of wind, surface circulation, hydrography, nutrients, and phytoplankton and zooplankton rate processes in a time series at 27 degree N during April 1973. A string of current meters and a towed acoustic body were also used to assess the distribution of subsurface currents and red crabs. The seasonal onset of upwelling had already occurred. Diatoms were initially the dominant primary producers. Two perturbations of the upwelling state were observed in response to relaxation of the winds. A comparison of this study with a preceding one in March 1972 indicates that the rate of upwelling, the nutrient content, and the phytoplankton specific growth rate were about the same in both years. The total productivity and biomass of the phytoplankton were less in 1973, implying that greater grazing stress was associated with a switch from smaller dinoflagellates to larger diatoms. Local temporal variability of upwelling off Baja California is postulated to have led to the replacement of clupeids by the red crab, Pleuroncodes planipes, as a facultative herbivore. JF - Limnology and Oceanography AU - Walsh, John J AU - Whitledge, Terry E AU - Kelley, James C AU - Huntsman, Susan A AU - Pillsbury, RDale AD - Oceanographic Sciences Division, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1977/03// PY - 1977 DA - March 1977 SP - 264 EP - 280 PB - Association for the Sciences of Limnology and Oceanography VL - 22 IS - 2 SN - 0024-3590, 0024-3590 KW - Ecology Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Upwelling KW - Bacillariophyceae KW - Phytoplankton KW - Nutrients KW - Hydrography KW - Feeding behaviour KW - Wind KW - Acoustics KW - Grazing KW - Zooplankton KW - Stress KW - Biomass KW - Herbivores KW - Plankton KW - Diatoms KW - Dinoflagellates KW - Crustaceans (decapod) (crabs) KW - Growth rate KW - Marine KW - Plankton surveys KW - Decapoda KW - Temporal variations KW - Ocean circulation KW - Pleuroncodes planipes KW - Nutrient content KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808654569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Further+transition+states+of+the+Baja+California+upwelling+ecosystem+1+%2C+2&rft.au=Walsh%2C+John+J%3BWhitledge%2C+Terry+E%3BKelley%2C+James+C%3BHuntsman%2C+Susan+A%3BPillsbury%2C+RDale&rft.aulast=Walsh&rft.aufirst=John&rft.date=1977-03-01&rft.volume=22&rft.issue=2&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1977.22.2.0264 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Growth rate; Plankton surveys; Herbivores; Feeding behaviour; Hydrography; Temporal variations; Grazing; Upwelling; Zooplankton; Ocean circulation; Phytoplankton; Plankton; Acoustics; Diatoms; Stress; Nutrients; Biomass; Nutrient content; Dinoflagellates; Wind; Crustaceans (decapod) (crabs); Decapoda; Bacillariophyceae; Pleuroncodes planipes; Marine DO - http://dx.doi.org/10.4319/lo.1977.22.2.0264 ER - TY - JOUR T1 - Some effects of patchy food environments on copepods 1 AN - 1808722608; PQ0003338231 AB - Laboratory determinations of the time taken for copepods to starve to death and of the effects of discontinuous food availability on egg production are used to demonstrate that different species are adapted to different scales of patchiness in their food environment. Acartia tonsa and Centropages typicus depend on constant food availability and are therefore sensitive to small scales of patchiness whereas Pseudocalanus minutus and Calanus finmarchicus can physiologically remove themselves from such small-scale variability. The success of these organisms in the natural environment may be related to the length of time that layers of food exist in the water column. JF - Limnology and Oceanography AU - Dagg, Michael AD - Oceanographic Sciences Division, Brookhaven National Laboratory, Upton, New York 11973. Y1 - 1977/01// PY - 1977 DA - January 1977 SP - 99 EP - 107 PB - Association for the Sciences of Limnology and Oceanography VL - 22 IS - 1 SN - 0024-3590, 0024-3590 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Copepods KW - Variability KW - Laboratories KW - Zooplankton KW - Limnology KW - Oceanography KW - Food availability KW - Environmental factors KW - Acartia tonsa KW - Foods KW - Centropages typicus KW - Pseudocalanus minutus KW - Patchiness KW - Calanus finmarchicus KW - AQ 00001:Water Resources and Supplies KW - Q1 08482:Ecosystems and energetics KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808722608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Some+effects+of+patchy+food+environments+on+copepods+1&rft.au=Dagg%2C+Michael&rft.aulast=Dagg&rft.aufirst=Michael&rft.date=1977-01-01&rft.volume=22&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1977.22.1.0099 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Zooplankton; Food availability; Environmental factors; Patchiness; Variability; Copepods; Foods; Laboratories; Limnology; Oceanography; Pseudocalanus minutus; Centropages typicus; Acartia tonsa; Calanus finmarchicus; Marine DO - http://dx.doi.org/10.4319/lo.1977.22.1.0099 ER - TY - JOUR T1 - Steemann Nielsen, E. 1975. Marine photosynthesis with special emphasis on the ecological aspects. Elsevier Sci. Publ. Co., Amsterdam and New York, x + 142 p. $21.75. AN - 1811895533; PQ0003527634 JF - Limnology and Oceanography AU - Walsh, John J AD - Oceanographic Sciences Division Brookhaven National Laboratory Upton, New York 11973. Y1 - 1976/07// PY - 1976 DA - July 1976 SP - 633 PB - Association for the Sciences of Limnology and Oceanography VL - 21 IS - 4 SN - 0024-3590, 0024-3590 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - ANW, USA, New York KW - ANE, Netherlands, Noord-Holland, Amsterdam KW - Photosynthesis KW - Brackish KW - Limnology KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q1 08481:Productivity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811895533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Steemann+Nielsen%2C+E.+1975.+Marine+photosynthesis+with+special+emphasis+on+the+ecological+aspects.+Elsevier+Sci.+Publ.+Co.%2C+Amsterdam+and+New+York%2C+x+%2B+142+p.+%2421.75.&rft.au=Walsh%2C+John+J&rft.aulast=Walsh&rft.aufirst=John&rft.date=1976-07-01&rft.volume=21&rft.issue=4&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1976.21.4.0633b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Photosynthesis; Limnology; ANW, USA, New York; ANE, Netherlands, Noord-Holland, Amsterdam; Marine; Brackish DO - http://dx.doi.org/10.4319/lo.1976.21.4.0633b ER - TY - JOUR T1 - Nitrogen fixation in Flax Pond: A Long Island salt marsh 1 AN - 1827903114; PQ0003641976 AB - Nitrogen fixation was measured by the acetylene reduction technique during summer 1973. Rates of fixation in the top 4 cm of all sediments ranged from 12 to about 800 mu g N fixed m super(-2) h super(-1). Fixation diminished with depth with none at 20 cm or below. Blue-green algal mats fixed at rates that ranged from 260-8,900 mu g N m super(2) h super(-1). No fixation was detected in the tidal water column, but rates of 8.6-4,800 mu g N liter super(-1) h super(-1) occurred in small stagnant pools on the marsh surface. Rates of fixation appeared not to vary between day and night. JF - Limnology and Oceanography AU - Whitney, DE AU - Woodwell, G M AU - Howarth, R W AD - Biology Department Brookhaven National Laboratory Upton, New York 11973. Y1 - 1975/07// PY - 1975 DA - July 1975 SP - 640 EP - 643 PB - Association for the Sciences of Limnology and Oceanography VL - 20 IS - 4 SN - 0024-3590, 0024-3590 KW - Ecology Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Pools KW - Limnology KW - Water column KW - Ponds KW - Islands KW - Nitrogen Fixation KW - Acetylene reduction KW - Marine KW - Tidewater KW - Ethyne KW - Salt Marshes KW - Algal mats KW - Marshes KW - Inland water environment KW - Sediments KW - Nitrogen fixation KW - Salt marshes KW - AQ 00001:Water Resources and Supplies KW - Q1 08463:Habitat community studies KW - SW 0810:General KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827903114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Nitrogen+fixation+in+Flax+Pond%3A+A+Long+Island+salt+marsh+1&rft.au=Whitney%2C+DE%3BWoodwell%2C+G+M%3BHowarth%2C+R+W&rft.aulast=Whitney&rft.aufirst=DE&rft.date=1975-07-01&rft.volume=20&rft.issue=4&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1975.20.4.0640 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Ethyne; Algal mats; Salt marshes; Nitrogen fixation; Marshes; Inland water environment; Sediments; Ponds; Acetylene reduction; Islands; Water column; Tidewater; Salt Marshes; Nitrogen Fixation; Limnology; Pools; Marine DO - http://dx.doi.org/10.4319/lo.1975.20.4.0640 ER - TY - JOUR T1 - Sedimentation rates in a Long Island marsh determined by super(210)Pb dating 1 AN - 1808720980; PQ0003338018 AB - Mean rates of vertical accretion of from 0.47 to 0.63 cm yr super(-1) have been determined for the past century from two widely separated sites at Flax Pond, a Spartina alterniflora marsh on the north shore of Long Island. Sediments were dated from super(210)Pb activity. The rates are equivalent to deposition of 325 to 436 g of dry organic matter m super(-2) yr super(-1) or about 146 to 196 g of carbon m super(-2) yr super(-1) Although the two sites differed in salt peat thickness, the basal layer of the peat was deposited about 100 years ago at both. JF - Limnology and Oceanography AU - Armentano, T V AU - Woodwell, G M AD - Biology Department Brookhaven National Laboratory Upton, New York 11973. Y1 - 1975/05// PY - 1975 DA - May 1975 SP - 452 EP - 456 PB - Association for the Sciences of Limnology and Oceanography VL - 20 IS - 3 SN - 0024-3590, 0024-3590 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Settling rate KW - Limnology KW - Shores KW - Ponds KW - Accretion KW - Carbon KW - Sedimentation KW - Spartina alterniflora KW - Marine KW - Organic matter KW - Aquatic plants KW - Carbon cycle KW - Oceanography KW - Marshes KW - Inland water environment KW - Sediments KW - Peat KW - Salt marshes KW - Dating KW - Chronostratigraphy KW - Deposition KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q1 08422:Environmental effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808720980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=Sedimentation+rates+in+a+Long+Island+marsh+determined+by+super%28210%29Pb+dating+1&rft.au=Armentano%2C+T+V%3BWoodwell%2C+G+M&rft.aulast=Armentano&rft.aufirst=T&rft.date=1975-05-01&rft.volume=20&rft.issue=3&rft.spage=452&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1975.20.3.0452 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Settling rate; Organic matter; Carbon cycle; Aquatic plants; Marshes; Inland water environment; Ponds; Sediments; Peat; Accretion; Carbon; Salt marshes; Chronostratigraphy; Sedimentation; Dating; Shores; Deposition; Limnology; Oceanography; Spartina alterniflora; Marine DO - http://dx.doi.org/10.4319/lo.1975.20.3.0452 ER - TY - JOUR T1 - An inexpensive, recording tide gauge 1 AN - 1808725330; PQ0003337723 AB - An inexpensive, recording tide gauge has been constructed and tested in a small tidal pond on the north shore of Long Island. The instrument costs less than $50 if a 0-1 mA recorder is already available. JF - Limnology and Oceanography AU - Tempel, Neal R AD - Biology Department Brookhaven National Laboratory Upton, New York 11973. Y1 - 1973/01// PY - 1973 DA - January 1973 SP - 178 EP - 180 PB - Association for the Sciences of Limnology and Oceanography VL - 18 IS - 1 SN - 0024-3590, 0024-3590 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Limnology KW - Shores KW - Oceanography KW - Inland water environment KW - Tides KW - Ponds KW - Recording equipment KW - Costs KW - Tide gauges KW - Materials Testing KW - AQ 00001:Water Resources and Supplies KW - Q1 08382:Ecological techniques and apparatus KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808725330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Limnology+and+Oceanography&rft.atitle=An+inexpensive%2C+recording+tide+gauge+1&rft.au=Tempel%2C+Neal+R&rft.aulast=Tempel&rft.aufirst=Neal&rft.date=1973-01-01&rft.volume=18&rft.issue=1&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Limnology+and+Oceanography&rft.issn=00243590&rft_id=info:doi/10.4319%2Flo.1973.18.1.0178 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Tide gauges; Inland water environment; Ponds; Recording equipment; Costs; Shores; Limnology; Oceanography; Materials Testing; Tides; Marine DO - http://dx.doi.org/10.4319/lo.1973.18.1.0178 ER - TY - JOUR T1 - Fallout and Marshallese AN - 1304001560 JF - Bulletin of the Atomic Scientists Y1 - 1970/03/01/ PY - 1970 DA - 1970 Mar 01 SP - 45 CY - Chicago, Ill. PB - Educational Foundation for Nuclear Science VL - 26 IS - 3 SN - 0096-3402 KW - Energy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1304001560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apio&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+the+Atomic+Scientists&rft.atitle=Fallout+and+Marshallese&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1970-03-01&rft.volume=26&rft.issue=3&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+the+Atomic+Scientists&rft.issn=00963402&rft_id=info:doi/ DB - Periodicals Index Online N1 - Last updated - 2013-02-24 ER - TY - JOUR T1 - CONCRETE-POLYMER MATERIALS, FIRST TOPICAL REPORT AN - 18965190; 6905835 AB - THE PREPARATION, TESTING, AND DEVELOPMENT OF COMPOSITE CONCRETE-POLYMER CONSTRUCTION MATERIALS ARE UNDER INVESTIGATION BY A JOINT PROGRAM OF THE BROOKHAVEN NATIONAL LABORATORY AND THE BUREAU OF RECLAMATION, WITH THE ASSISTANCE OF THE ATOMIC ENERGY COMMISSION AND OFFICE OF SALINE WATER. PREFORMED AIR-ENTRAINED CONCRETE AND MORTAR CAN BE FULLY IMPREGNATED WITH A MONOMER POLYMERIZED IN SITU EITHER BY RADIATION OR THERMALCATALYTIC TECHNIQUES. TESTS OF POLYMETHYL-METHACRYLATE AND POLYSTYRENE-IMPREGNATED CONCRETE SHOW IMPROVEMENTS OF: (1) 285% INCREASE IN COMPRESSIVE STRENGTH, (2) 292% INCREASE IN TENSILE STRENGTH, (3) 80% INCREASE IN MODULUS OF ELASTICITY, (4) 256% INCREASE IN MODULUS OF RUPTURE, (5) 44% INCREASE IN FLEXURAL MODULUS, (6) OVER 300% INCREASE IN FREEZE-THAW RESISTANCE, (7) 73% INCREASE IN IMPACT HAMMER TEST VALUES, (8) DECREASE IN WATER PERMEABILITY TO NEGLIGIBLE VALUES, (9) UP TO 95% DECREASE IN WATER ABSORPTION, AND (10) NEGLIGIBLE CORROSION IN DISTILLED WATER AND SULFATE BRINES. POTENTIAL APPLICATIONS OF CONCRETE-POLYMER INCLUDE: SEWER AND PRESSURE PIPE, BUILDING MATERIALS FOR HOUSING AND UNDERWATER STRUCTURES, CORROSION-RESISTANT CONCRETE FOR DESALTING PLANTS, AND ANTIFRAGMENTATION CONCRETE. (USBR) JF - BROOKHAVEN NAT LAB REP BNL 50134 (T-509) AND BUR RECLAM GEN REP 41, DEC 1968. 83 P, 43 FIG, 55 TAB, 14 REF. AVAILABLE FROM CLEARINGHOUSE AS BNL 50 134 AT $3.00 IN PAPER COPY AND $0.65 IN MICROFICHE. AU - Steinberg, M AU - Dikeou, J T AU - KUKACKA, LE AU - Backstrom, Je AU - Colombo, P AD - BROOKHAVEN NATIONAL LABORATORY, UPTON, N. Y.; BUREAU OF RECLAMATION, DENVER, COLO Y1 - 1968/12// PY - 1968 DA - Dec 1968 KW - Water Resources Abstracts KW - *CONCRETE TECHNOLOGY KW - *CONCRETES KW - *COMPOSITE MATERIALS KW - *IMPREGNATION KW - CONCRETE MIXES KW - CONCRETE TESTING KW - CONCRETE STRUCTURES KW - BUILDING MATERIALS KW - MATERIALS KW - MATERIALS ENGINEERING KW - POLYMERS KW - CHEMICAL PROPERTIES KW - PHYSICAL PROPERTIES KW - CONSTRUCTION MATERIALS KW - *POLYMERIZATION KW - *CONCRETE-POLYMER MATERIALS KW - POLYMETHYL METHACRYLATE KW - CONCRETE PROPERTIES KW - CORROSION RESISTANCE KW - POLYSTYRENE KW - SW 6060:Concrete KW - SW 6070:Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18965190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=CONCRETE-POLYMER+MATERIALS%2C+FIRST+TOPICAL+REPORT&rft.au=Steinberg%2C+M%3BDikeou%2C+J+T%3BKUKACKA%2C+LE%3BBackstrom%2C+Je%3BColombo%2C+P&rft.aulast=Steinberg&rft.aufirst=M&rft.date=1968-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - The response of the skin of swine to increasing single exposures of 250-KVP X-rays. AN - 76348849; 17387948 AB - When the skin of the shoulder ("A" field) and lower back ("C" field) is irradiated through 10-cm-diameter fields with 250-kVp x-rays, having a HVL of 0.87 mm copper, a dose range is reached between approximately 1600 rads and 3000 rads in which a moist reaction is or is not formed. If a moist reaction is formed, it either heals completely, partially, or not at all. The evolution, time course, and dose dependence of the moist reaction that occurs following irradiation has been determined. The moist reaction is found at 17.5 +/- 0.6 days in the "A" field, and 20.8 +/-0.8 days in the "C" field. The reaction evolves to involve from 5 % to 100% of the field by 24.9 +/- 0.5 days in the "A" field and by 28.5 +/- 1.0 days in the "C" field. Healing is complete by 36.0 +/-1.0 days in the "A" field and by 38.0 +/- 1.3 days in the "C" field. The area of the field involved with a moist reaction at the time of maximal involvement is dose-dependent. The area of the field involved with a moist reaction at the time of complete healing is also dose-dependent. The dose at which 50 % of the fields were not healed was 2273 +/-103 rads in the "A" field, 2578 +/-141 rads in the "C" fields, and 2437 +/- 89 rads in the "A" and "C" fields. The values in the "C" field are significantly different from those in the "A" field except for the dose at which 50 % of the fields were not healed and the time at which the field was maximally healed. JF - Radiation research AU - Archambeau, J O AU - Mathieu, G R AU - Brenneis, H J AU - Thompson, K H AU - Fairchild, R G AD - Brookhaven National Laboratory, Upton, New York, USA. Y1 - 1968/11// PY - 1968 DA - November 1968 SP - 299 EP - 326 VL - 36 IS - 2 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Swine KW - Radiation Dosage KW - Animals KW - Dose-Response Relationship, Radiation KW - Environmental Exposure -- adverse effects KW - Male KW - Female KW - Erythema -- etiology KW - Radiodermatitis -- etiology KW - Erythema -- pathology KW - Skin -- radiation effects KW - Radiodermatitis -- pathology KW - Skin -- pathology KW - X-Rays -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76348849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=The+response+of+the+skin+of+swine+to+increasing+single+exposures+of+250-KVP+X-rays.&rft.au=Archambeau%2C+J+O%3BMathieu%2C+G+R%3BBrenneis%2C+H+J%3BThompson%2C+K+H%3BFairchild%2C+R+G&rft.aulast=Archambeau&rft.aufirst=J&rft.date=1968-11-01&rft.volume=36&rft.issue=2&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2007-03-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The RBE of 2.2-BeV protons for 30-day lethality in mice. AN - 76346929; 17387943 AB - BNL Swiss Albino mice were exposed (five in tandem) in a 2.5-cm I.D. Lucite tube to a parallel beam of 2.2-BeV protons. The LD5o was 1.81+/-0.03 X 10(10) p/cm(2), or 641 rads. The corresponding LD50 for 250-kVp x-rays was 557 rads, yielding an RBE of 0.87. No difference in time pattern of death was observed between the x-irradiated and proton-irradiated animals. It is concluded that, with the exposure geometry used in these experiments, ionization by primary and high-energy secondary protons was the major dose constituent. A comparison is made with other experiments on the lethal effects of protons in which different geometries were employed. There is evidence that, with exposure in material of larger diameter in which there is a larger contribution to dose from lateral scatter, high-LET components of the beam may play a more dominant role. It was also observed in these experiments that the presence of Pseudomonas aeruginosa may result in a lower LD50 and "early death," following either x-irradiation or proton radiation. This may have accounted for some of the "early deaths" following proton irradiation reported earlier. JF - Radiation research AU - Jesseph, J E AU - Moore, W H AU - Straub, R F AU - Tisljar-Lentulis, G M AU - Bond, V P AD - Medical Research Center and the Accelerator Department, Brookhaven National Laboratory, Upton, New York, USA. Y1 - 1968/11// PY - 1968 DA - November 1968 SP - 242 EP - 253 VL - 36 IS - 2 SN - 0033-7587, 0033-7587 KW - Protons KW - 0 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Animals KW - Body Burden KW - Lethal Dose 50 KW - Mice KW - Dose-Response Relationship, Radiation KW - Male KW - Survival Analysis KW - Protons -- adverse effects KW - Relative Biological Effectiveness KW - Survival Rate KW - Whole-Body Irradiation -- adverse effects KW - Radiometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76346929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=The+RBE+of+2.2-BeV+protons+for+30-day+lethality+in+mice.&rft.au=Jesseph%2C+J+E%3BMoore%2C+W+H%3BStraub%2C+R+F%3BTisljar-Lentulis%2C+G+M%3BBond%2C+V+P&rft.aulast=Jesseph&rft.aufirst=J&rft.date=1968-11-01&rft.volume=36&rft.issue=2&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2007-03-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Neutron autoradiographic determination of boron-10 concentration and distribution in mammalian tissue. AN - 76351887; 17387929 AB - The application of a low-background neutron autoradiographic technique for determining 10B concentration and intracellular distribution in mammalian tissue is described. Knowledge of 10B concentration and distribution on a cellular level is necessary to evaluate the effects of irradiation when using the 10B(n,alpha)7Li reaction in experimental therapeutic procedures. Conventional boron analysis is not capable of extracting this information. The use of freeze-dried tissues, dry-mounted on nuclear emulsion, makes the technique applicable to water-soluble compounds used in previous clinical trials, as well as to water-insoluble proteins. Absolute concentrations of 10B in the form of sodium pentaborate were measured in mouse spleen, liver, kidney, muscle, tumor, and brain, 30 minutes after intraperitoneal injection, and compared to results from three other laboratories using conventional analysis. Boron concentrations similar to those used in previous clinical trials were evaluated to demonstrate the feasibility of the method. No intranuclear or extracellular concentration was observed; evidence is given to demonstrate the absence of leaching of the water-soluble compound. The method described will be useful in evaluating the newer boron compounds attached to proteins. The intracellular distribution of these compounds is of particular interest, since it is not clear that all proteins are capable of penetrating cell walls. JF - Radiation research AU - Fairchild, R G AU - Tonna, E A AU - Seibold, C T AU - Straub, R F AD - Medical Research Center, Brookhaven National Laboratory, Upton, New York, USA. Y1 - 1968/10// PY - 1968 DA - October 1968 SP - 87 EP - 97 VL - 36 IS - 1 SN - 0033-7587, 0033-7587 KW - Isotopes KW - 0 KW - Boron KW - N9E3X5056Q KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Isotopes -- metabolism KW - Metabolic Clearance Rate KW - Organ Specificity KW - Tissue Distribution KW - Isotopes -- analysis KW - Neutrons KW - Boron -- analysis KW - Neutron Activation Analysis -- methods KW - Radiometry -- methods KW - Autoradiography -- methods KW - Boron -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76351887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Neutron+autoradiographic+determination+of+boron-10+concentration+and+distribution+in+mammalian+tissue.&rft.au=Fairchild%2C+R+G%3BTonna%2C+E+A%3BSeibold%2C+C+T%3BStraub%2C+R+F&rft.aulast=Fairchild&rft.aufirst=R&rft.date=1968-10-01&rft.volume=36&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2007-03-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - REMOVAL OF IRON FROM ACID MINE WITH THE AID OF HIGH ENERGY RADIATION, PART III AN - 18950617; 6900237 AB - EXPERIMENTAL DATA ARE PRESENTED ON THE RATE OF OXIDATION AND REMOVAL OF FERROUS IRON FROM FULTON BOREHOLE ACID MINE DRAINAGE, A HIGH IRON (350 PPM) ACID WATER (PH-3.1) BY MECHANICAL AGITATION AND AERATION WITH A LARGE EXCESS OF CRUSHED LIMESTONE AND WITH THE EFFECT OF RADIATION. IT APPEARS THAT UP TO 83.5 PPM/MIN OF FE REMOVAL CAN BE OBTAINED WITH LIMESTONE NEUTRALIZATION ALONE AT A PH LESS THAN 6.5 AT A TEMPERATURE OF 10 DEG C. PARTICLE SIZE, DEGREE OF AGITATION, AND MASS RATIO OF LIMESTONE TO MINE WATER APPEAR TO BE IMPORTANT VARIABLES IN OBTAINING HIGH REMOVAL AND NEUTRALIZATION RATES. WHEREAS CO-60 GAMMA RADIATION CAN YIELD HIGH RATES AND HIGH CHAIN G VALUES FOR FE REMOVAL IN THE ABSENCE OF VIGOROUS AGITATION, THE INCREMENTAL CONTRIBUTION OF RADIATION DECREASES AS THE RATE OF NEUTRALIZATION BY LIMESTONE INCREASES. IT WOULD BE DIFFICULT TO JUSTIFY A RADIATION PROCESS IN VIEW OF THE RATE OF IRON REMOVAL THAT HAS ALREADY BEEN OBSERVED WITH LIMESTONE NEUTRALIZATION. BASED ON THIS STUDY AND STUDIES OF THE U S BUREAU OF MINES IT IS SUGGESTED THAT AN ENGINEERING DEVELOPMENT PROGRAM BE UNDERTAKEN FOR TREATING FULTON BOREHOLE DRAINAGE WITH FIELD LIMESTONE. (KNAPP-USGS) JF - REPRINTS OF PAP 2D SYMP ON COAL MINE DRAINAGE RES, MELLON INST, PP 308-318, MAY 1968. 11 P, 4 TAB, 4 REF. AU - Steinberg, M AU - Pruzansky, J AU - Jefferson, L R AD - BROOKHAVEN NATIONAL LABORATORY, UPTON, NEW YORK Y1 - 1968/05// PY - 1968 DA - May 1968 KW - Water Resources Abstracts KW - *ACID MINE WATER KW - *POLLUTION ABATEMENT KW - *WASTE WATER TREATMENT KW - *AERATION KW - *IRRADIATION KW - COBALT RADIOISOTOPES KW - CALCIUM CARBONATE KW - IRON OXIDES KW - ACIDITY KW - LIMESTONES KW - *IRON REMOVAL KW - FULTON BOREHOLE ACID MINE DRAINAGE KW - SW 3040:Wastewater treatment processes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18950617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=REMOVAL+OF+IRON+FROM+ACID+MINE+WITH+THE+AID+OF+HIGH+ENERGY+RADIATION%2C+PART+III&rft.au=Steinberg%2C+M%3BPruzansky%2C+J%3BJefferson%2C+L+R&rft.aulast=Steinberg&rft.aufirst=M&rft.date=1968-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - USE OF AN ANALOG COMPUTER IN STUDIES OF STRONTIUM AND CALCIUM METABOLISM IN MAN * AN - 1850792121; PQ0003923709 JF - Annals of the New York Academy of Sciences AU - Robertson, J S AU - Cohn, SH AD - Medical Research Center, Brookhaven National Laboratory, Upton, L.I, N.Y. Y1 - 1963/05// PY - 1963 DA - May 1963 SP - 122 EP - 127 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 108 IS - 1 SN - 0077-8923, 0077-8923 KW - Immunology Abstracts; Environment Abstracts KW - Calcium KW - Strontium KW - Metabolism KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850792121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=USE+OF+AN+ANALOG+COMPUTER+IN+STUDIES+OF+STRONTIUM+AND+CALCIUM+METABOLISM+IN+MAN+*&rft.au=Robertson%2C+J+S%3BCohn%2C+SH&rft.aulast=Robertson&rft.aufirst=J&rft.date=1963-05-01&rft.volume=108&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.1963.tb13369.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Calcium; Strontium; Metabolism DO - http://dx.doi.org/10.1111/j.1749-6632.1963.tb13369.x ER - TY - JOUR T1 - The biological effects of heavy cosmic ray particles. AN - 83125411; 12056427 AB - There has been rather extensive biological experience with most of the radiations known to exist in space beyond the earth's atmosphere, with the exception of the very high energy heavy particles which form a small part of the galactic cosmic rays. These particles cannot be reproduced in the laboratory, but from experiments with smaller particles, and from theoretical considerations, there was reason to fear they might be very damaging biologically. A very narrow beam of 22 MeV deuterons has been developed which will have the same biological effect as the track of a very heavily ionizing particle. Using this microbeam the following results have been obtained on mice: (1) brain tissue is very insensitive to this type of radiation, (2) this radiation will cause minute abnormalities in the lens of the eye but in general these do not progress to form cataracts; but if they do, they remain extremely small, (3) if a hair follicle is hit, the hair from that follicle will turn grey. It is concluded that the heavy cosmic ray particles do not pose a serious problem for manned space flight. JF - Life sciences and space research AU - Curtis, H J AD - Biology Department, Brookhaven National Laboratory, Upton, New York, USA. Y1 - 1963 PY - 1963 DA - 1963 SP - 39 EP - 47 VL - 1 SN - 0075-9422, 0075-9422 KW - Deuterium KW - AR09D82C7G KW - Space life sciences KW - Radiation Dosage KW - Animals KW - Relative Biological Effectiveness KW - Heavy Ions KW - Cyclotrons KW - Mice KW - Visual Cortex -- radiation effects KW - Hair Follicle -- radiation effects KW - Cosmic Radiation KW - Deuterium -- adverse effects KW - Lens, Crystalline -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/83125411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences+and+space+research&rft.atitle=The+biological+effects+of+heavy+cosmic+ray+particles.&rft.au=Curtis%2C+H+J&rft.aulast=Curtis&rft.aufirst=H&rft.date=1963-01-01&rft.volume=1&rft.issue=&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Life+sciences+and+space+research&rft.issn=00759422&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-13 N1 - Date created - 2002-06-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - BIOLOGICAL MECHANISMS UNDERLYING THE AGING PROCESS AN - 60589717; 64B3888 AB - The several theories put forward to explain the biological mechanisms underlying the aging process have been examined. The only ones which attack the problem from the point of view of basic biological mechanisms are the 'wear & tear' theory & the 'somatic mutation' theory. The fact that radiation accelerates the aging process gives a potent tool for attacking the problem exp'ly. Exp's with mice specifically designed to verity the former theory showed conclusively that stress per se does not contribute to aging, & no exp'al evidence could be found to support this theory. On the other hand, a great deal of evidence is now available indicating that mutations in somatic cells play a dominant role in aging. It is further shown that the organs having cells which undergo cell division frequently, take part in the aging process very little, if at all. Organs having cells which seldom, if ever, undergo cell division have no opportunity to throw off either spontaneous or induced mutations, & it is these organs which are responsible for the aging of the animal. Spontaneous mutations build up at a rapid rate in these organs. It is shown that a cell may continue to function normally long after it has suffered a deleterious mutation, & this accounts for much of the delay in the expression of radiation damage. It is suggested that the mutation rates of somatic cells are very much higher than those for gametic cells; & this circumstance insures the death of the individual & the survival of the species. AA. JF - Science AU - Curtis, Howard J AD - BROOKHAVEN NATIONAL LABORATORY, UPTON, NY Y1 - 1963///23, PY - 1963 DA - 23, 1963 SP - AUG, 686 EP - 693 VL - 141 IS - 3582 SN - 0036-8075, 0036-8075 KW - BIOLOGICAL : MECHANISMS OF AGING PROCESS, KW - MECHANISMS : BIOLOGICAL, OF AGING PROCESS, KW - AGING : PROCESS, BIOLOGICAL MECHANISMS OF, KW - Mechanism/Mechanisms KW - Aging (see also Aged, Geriatric) KW - Biology/Biological KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60589717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science&rft.atitle=BIOLOGICAL+MECHANISMS+UNDERLYING+THE+AGING+PROCESS&rft.au=Curtis%2C+Howard+J&rft.aulast=Curtis&rft.aufirst=Howard&rft.date=1963-01-01&rft.volume=141&rft.issue=3582&rft.spage=AUG&rft.isbn=&rft.btitle=&rft.title=Science&rft.issn=00368075&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SCIEAS N1 - SubjectsTermNotLitGenreText - Biology/Biological; Mechanism/Mechanisms; Aging (see also Aged, Geriatric) ER - TY - BOOK T1 - U.S.-India-China Cities Collaboration on Energy and Environment AN - 744583728; 12575338 AB - Recent national and international debates on energy, environment and climate change have highlighted the importance of involving rapidly growing developing countries for adopting sustainable energy, environment and development practices. In the absence of a national or state policy on sustainable energy and environmental practices, cities can be at the fore-front of implementing ground breaking policies. As evident from various national and international case-studies, this bottom-up approach is effective in bringing change from within. Brookhaven National Laboratory supports US Department of Energy for the seven countries Asia-Pacific Partnership on Clean Development and Climate - an innovative effort to accelerate the development and deployment of clean energy technologies. The project is promoting dialogues for sharing best practices and technologies between cities of U.S., India and China, involving city agencies, businesses, professionals, citizens, and research and academic institutions. The partnerships focus on mutually agreeable programs, including green buildings, energy efficiency, renewable technologies, alternative fuel vehicles, recycling, water supply and sanitation, green government purchasing and deployable clean technologies. The paper will highlight such case studies.The cities collaboration will equip urban decision makers with fundamental understanding of effective policy measures and tools to identify and respond to a range of barriers that limit implementation and management of sustainable urban development practices, service delivery and plans. JF - Papers from the Annual Meeting of the Association of American Geographers - 2009 AU - Bhatt, Vatsal PB - Association of American Geographers, 1710 16th St, NW Washington, DC 20009 USA KW - Sustainability Science Abstracts KW - Fuel technology KW - Development projects KW - Climatic changes KW - Sustainable development KW - Recycling KW - Water supplies KW - India KW - Waste management KW - Urban planning KW - best practices KW - Sanitation KW - State policies KW - green development KW - Urban areas KW - Energy efficiency KW - Land use KW - USA KW - China, People's Rep. KW - innovations KW - Developing countries KW - Technology KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744583728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Sustainability+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bhatt%2C+Vatsal&rft.aulast=Bhatt&rft.aufirst=Vatsal&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=U.S.-India-China+Cities+Collaboration+on+Energy+and+Environment&rft.title=U.S.-India-China+Cities+Collaboration+on+Energy+and+Environment&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-12-14 ER - TY - BOOK T1 - Adding to the Mercury Speciation Toolbox AN - 20921681; 8328049 AB - Mercury was used to separate lithium-6 isotope for weapons production at the Y-12 Plant in Oak Ridge, TN in the 1950s and 1960s. A large portion of the waste Hg entered the environment and continues to move throughout the sub-surface and surface waters in the area. Environmental management of Hg contamination within this complex hydrologic system, where Hg speciation and the mobile fraction have been found to vary widely, will require ongoing characterization and predictive modeling of Hg speciation. State-of-the-art spectroscopic tools that can directly probe Hg speciation in preserved aqueous and sediment samples with greater sensitivity, however, are required to determine rates and mechanisms of biogeochemical reactions. We will present the first results demonstrating the use of x-ray absorption spectroscopy (XAS) at the Hg M5 edge (2295 eV) to fingerprint Hg species. Heavy-metal M5 absorption edges can have very sharp features due to local electron transitions, and therefore, we are developing this edge as a tool for quantitative measurement of Hg species. In addition, sulfur speciation using the sulfur K absorption edge, which is at a similar energy (2472 eV), can be measured in the same scan as the Hg M5 edge. Potentially important organic and inorganic sulfur species (sulfide, disulfide, elemental sulfur, sulfite and sulfate) are readily differentiated, and thereby, provides an independent method for monitoring the redox state of the system along with changes in S-Hg bonding. We will also present x-ray microprobe 2-D concentration maps of Hg and other elements at the grain and pore scales to identify its microscopic distribution and chemical associations. When used in combination with established sequential extraction and direct spectroscopic methods, the addition of XAS at the Hg M5 edge should provide a significant advancement in the determination of Hg speciation in complex biogeochemical environments. JF - Proceedings of the American Geophysical Union 2007 Fall Meeting AU - Fitts, J P AU - Northrup, P A AU - Chidambaram, D AU - Kalb, P D KW - Water Resources Abstracts KW - B11B-0413 KW - 0409 Bioavailability: chemical speciation and complexation KW - 0452 Instruments and techniques KW - 0461 Metals KW - 0488 Sulfur cycling KW - Sulfur KW - Sulfates KW - Speciation KW - Isotopes KW - Surface water KW - Sulfites KW - Surface Water KW - X-rays KW - Absorption spectroscopy KW - Hydrologic Models KW - Absorption KW - Geophysics KW - heavy metals KW - Sediment pollution KW - Biogeochemistry KW - Sulfides KW - USA, Tennessee, Oak Ridge KW - Weapons KW - Mercury KW - Environment management KW - SW 3010:Identification of pollutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20921681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Water+Resources+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Fitts%2C+J+P%3BNorthrup%2C+P+A%3BChidambaram%2C+D%3BKalb%2C+P+D&rft.aulast=Fitts&rft.aufirst=J&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Adding+to+the+Mercury+Speciation+Toolbox&rft.title=Adding+to+the+Mercury+Speciation+Toolbox&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-12-21 ER - TY - BOOK T1 - Long term non-destructive soil carbon monitoring in tillage and no-tillage systems AN - 19362517; 7087253 AB - Increasing soil carbon content serves as a balancing act attempting to mitigate anthropogenic CO sub(2) emissions into the atmosphere in order to slow down gradual global warming. In addition, it is well recognized that an increase in carbon soil content improves the soil quality and productivity. However, lack of non-invasive tools for soil analysis and our limited understanding of the belowground processes hinders our ability to evaluate carbon sequestration efficacy and assess soil carbon stores. One of the methods, looked upon here, of increasing soil carbon sequestration is switching from till to no-till soil management practices. Carbon has been shown to increase in many continuous no-tillage systems compared to tilled systems. Less is known about the fate of carbon when systems are changed relative to tillage. Carbon will be measured on long-term research plots (established in 1981) comparing three no-tillage soybean-cropping systems to three tilled systems. In the spring of 2002 all plots were randomly split and sampled for soil carbon and nitrogen on each side. After sampling, one side of each of the no-till and tilled plots was converted to the other tillage system. Converted plots were then sampled after the tillage conversion and all plots have been sampled each year since conversion. These data will allow the opportunity to monitor carbon changes in long-term and short-term no-tilled and tilled systems in a controlled randomized replicated experiment. We also will be sampling landscape transects across soil types and positions to evaluate terrestrial carbon spatial variation and storage. This data set, obtained by conventional destructive sampling and wet chemistry, will be compared to results obtained with a novel Soil Carbon ANalysis (SCAN) instrument that measures non-destructively soil carbon content in a continuous scan over large area. The instrument probes the soil to an approximate depth of 20 to 30 cm, depending on the soil conditions, with a footprint of about 150 cm. Such a measurement, besides being non-destructive, provides a mean carbon value for a large volume thus smoothing any possible normal lateral variability in the soil carbon content. The instrument can be used in a stationary mode, or in a mobile mode for an integrated estimate over a large area. This is in contrast to core samples that represent point measurements and for larger field sizes require a large number of cores to reduce the error to an acceptable level. The results will be rank correlated and using in-field calibration will be compared in carbon-estimated values. The predictions of the carbon content for the entire field based on stationary and scanning results will be also evaluated. Discussion of the planned experiments and the analysis will be presented. JF - GREENHOUSE GASES & CARBON SEQUESTRATION IN AGRICULTURE AND FORESTRY. AU - Wielopolski, L AU - Mitra, S AU - Tyler, D AU - Denton, P AU - Eash, N AU - Essington, M PB - Kansas State University KW - Pollution Abstracts; Sustainability Science Abstracts KW - Agriculture KW - soil types KW - No-till cropping KW - Calibration KW - Greenhouse effect KW - Carbon sequestration KW - Soil analysis KW - Efficacy KW - Tillage KW - Emissions KW - Global warming KW - Water springs KW - Sampling KW - Carbon dioxide KW - Greenhouse gases KW - Nitrogen KW - Forestry KW - P 0000:AIR POLLUTION KW - M3 1110:Atmosphere UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19362517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Sustainability+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wielopolski%2C+L%3BMitra%2C+S%3BTyler%2C+D%3BDenton%2C+P%3BEash%2C+N%3BEssington%2C+M&rft.aulast=Wielopolski&rft.aufirst=L&rft.date=&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Long+term+non-destructive+soil+carbon+monitoring+in+tillage+and+no-tillage+systems&rft.title=Long+term+non-destructive+soil+carbon+monitoring+in+tillage+and+no-tillage+systems&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 ER -