FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Xu, K Zhang, SS Jow, R AF Xu, K Zhang, SS Jow, R TI Electrochemical impedance study of graphite/electrolyte interface formed in LiBOB/PC electrolyte SO JOURNAL OF POWER SOURCES LA English DT Article DE LiBOB electrolytes; electrochemical impedance; graphite/electrolyte interface ID LITHIUM BIS(OXALATO)BORATE; GRAPHITE-ELECTRODES; INTERCALATION AB Electrochemical impedance measurements were performed on graphitic anodes during their galvanostatic cycling in LiBOB/PC electrolyte, and the variation of each impedance component was studied as the function of the lithiation state. It was found that the charge-transfer component was closely related to the formation of the solid electrolyte interface (SEI), characterized by a sharp drop in the corresponding resistances between OCV and 0.60 V, while the semi-circle in the medium frequency range might arise from contact impedance components within the electrode, because it varies reversibly during the lithiation/delithiation cycle. The irreversible reduction process at 1.70 V, which is characteristic of LiBOB salt, was confirmed to originate from the reductive decomposition of oxalate ester impurities, and this process is believed to be unrelated to the protective SEI formed by LiBOB electrolytes on graphitic anode. When compared with the Corresponding LiPF6-based electrolytes, it was concluded that the alkyl carbonates are not appropriate solvents for LiBOB salt, both in terms of the power and low temperature performances in lithium ion cells. Published by Elsevier B.V. C1 USA, Res Lab, Senson & Electron Device Directorate, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Res Lab, Senson & Electron Device Directorate, Adelphi, MD 20783 USA. EM cxu@arl.army.mil RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 11 TC 59 Z9 69 U1 2 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD APR 27 PY 2005 VL 143 IS 1-2 BP 197 EP 202 DI 10.1016/j.jpowsour.2004.11.026 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 927BE UT WOS:000229166600024 ER PT J AU Swenson, DL Warfield, KL Negley, DL Schmaljohn, A Aman, MJ Bavari, S AF Swenson, DL Warfield, KL Negley, DL Schmaljohn, A Aman, MJ Bavari, S TI Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections SO VACCINE LA English DT Article DE hybrid; immunity; antibody; viremia; adjuvant; guinea pigs ID PROTECT GUINEA-PIGS; EQUINE ENCEPHALITIS-VIRUS; NONHUMAN-PRIMATES; HEMORRHAGIC-FEVER; IMMUNE-RESPONSE; DNA VACCINES; GLYCOPROTEIN; MICE; IDENTIFICATION; IMMUNIZATION AB A safe and effective pan-filovirus vaccine is highly desirable since the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) cause highly lethal disease typified by unimpeded viral replication and severe hemorrhagic fever. Previously, we showed that expression of the homologous glycoprotein (GP) and matrix protein VP40 from a single filovirus, either EBOV or MARV, resulted in formation of wild-type virus-like particles (VLPs) in mammalian cells. When used as a vaccine, the wild-type VLPs protected from homologous filovirus challenge. The aim of this work was to generate a multi-agent vaccine that would simultaneously protect against multiple and diverse members of the Filoviridae family. Our initial approach was to construct hybrid VLPs containing heterologous viral proteins, of EBOV and MARV, and test the efficacy of the hybrid VLPs in a guinea pig model. Our data indicate that vaccination with GP was required and sufficient to protect against a homologous filovirus challenge, as heterologous wild-type VLPs or hybrid VLPs that did not contain the homologous GP failed to protect. Alternately, we vaccinated guinea pigs with a mixture of wild-type Ebola and Marburg VLPs. Vaccination with a single dose of the multivalent VLP vaccine elicited strong immune responses to both viruses and protected animals against EBOV and MARV challenge. This work provides a critical foundation towards the development of a pan-filovirus vaccine that is safe and effective for use in primates and humans. Published by Elsevier Ltd. C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. Clin Res Management, Frederick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM dana.swenson@det.amedd.army.mil; kelly.warfield@det.amedd.army.mil; diane.negley@det.amedd.army.mil; alan.schmaljohn@det.amedd.army.mil; javad.aman@det.amedd.army.mil; sina.bavari@amedd.army.mil NR 39 TC 81 Z9 87 U1 1 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR 27 PY 2005 VL 23 IS 23 BP 3033 EP 3042 DI 10.1016/j.vaccine.2004.11.070 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 920KK UT WOS:000228687600013 PM 15811650 ER PT J AU Wang, A Hsieh, AJ Rutledge, GC AF Wang, A Hsieh, AJ Rutledge, GC TI Electrospinning of poly(MMA-co-MAA) copolymers and their layered silicate nanocomposites for improved thermal properties SO POLYMER LA English DT Article DE electrospinning; nanocomposite; nanofiber ID SITU INTERCALATIVE POLYMERIZATION; ELECTRICALLY FORCED JETS; NYLON 6-CLAY HYBRID; MECHANICAL-PROPERTIES; DIAMETER FIBERS; NANOFIBERS; POLYSTYRENE; MORPHOLOGY; RHEOLOGY; METHACRYLATE) AB Copolymers consisting of methyl methacrylate (MMA) and methacrylic acid (MAA) and their layered silicate nanocomposites were electrospun to form fibers with diameters in the sub-micron range. The presence of MAA increased the T-g and thermal stability of the copolymers through formation of anhydrides upon heating. Fibers of uniform diameters were obtained for the poly(MMA-co-MAA) copolymers and nanocomposites containing montmorillonite (MMT), while protrusions were observed on the electrospun fibers from nanocomposites containing fluorohectorite (FH). The electrospinnability of copolymer solutions and nanocomposite dispersions predicted based on both rheological analyses and conductivity measurements correlates well with the experimental electrospinning observations. Dispersion of clays within the nanocomposites improved the electrospinnability of the nanocomposite dispersions. MMT is predominantly exfoliated and well distributed within the fiber and oriented along the fiber axis. Char formation was observed when the MMT-containing fibers were heated above the decomposition temperature, indicating a potential for reduced flammability and increased self-extinguishing properties, whereas the FH-containing materials disintegrated into either film or powder form. (c) 2005 Elsevier Ltd. All rights reserved. C1 MIT, Dept Chem Engn, Cambridge, MA 02139 USA. USA, Res Lab, AMSRD, ARL,WM,MD, Aberdeen Proving Ground, MD 21005 USA. RP Rutledge, GC (reprint author), MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM rutledge@mit.edu NR 61 TC 75 Z9 77 U1 1 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD APR 25 PY 2005 VL 46 IS 10 BP 3407 EP 3418 DI 10.1016/j.polymer.2005.02.099 PG 12 WC Polymer Science SC Polymer Science GA 919ET UT WOS:000228601800022 ER PT J AU Paranavitana, C Zelazowska, E Izadjoo, M Hoover, D AF Paranavitana, C Zelazowska, E Izadjoo, M Hoover, D TI Interferon-gamma associated cytokines and chemokines produced by spleen cells from Brucella-immune mice SO CYTOKINE LA English DT Article DE chemokine; cytokine; mouse; spleen cells ID LISTERIA-MONOCYTOGENES; INTERLEUKIN-12 IL-12; ABORTUS INFECTION; RESPONSES; MIP-1-ALPHA; VACCINATION; EXPRESSION; RESISTANCE; INDUCTION; SECRETION AB It is known that interferon (IFN)-gamma plays a critical role in protection against brucellosis. In this study we have investigated several cytokines and chemokines that are associated with IFN-gamma for potential in vitro correlates of protection. We cultured spleen cells in vitro from mice immunized orally with a live, attenuated Brucella melitensis vaccine candidate (WR201) and stimulated these cells with a lysate of B. melitensis. Differential gene expression of several cytokines and chemokines in stimulated spleen cells was analysed by real-time PCR, and secreted proteins were determined by ELISA. Immunized mice produced higher levels of both protein and gene transcripts for IFN-gamma, interleukin (IL)-2, IL-18 and MIP1-alpha. Immunized mice also had elevated gene expression levels for IL12-p40, IL23-p19, IP-10, MIG and MCP-1 when compared to normal mice. In this study we have identified new cytokines and cherrtokines as potential immune correlates in responses to protection in Brucella-vaccinated mice. (c) 2005 Elsevier Ltd. All rights reserved. C1 Walter Reed Army Inst Res, Dept Bacterial Dis, Silver Spring, MD 20910 USA. RP Paranavitana, C (reprint author), Walter Reed Army Inst Res, Dept Bacterial Dis, Bldg 503,Room 3E10,Robert Grant Ave, Silver Spring, MD 20910 USA. EM chrysanthi.paranavitana@na.amedd.army.mil NR 22 TC 21 Z9 24 U1 0 U2 2 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1043-4666 J9 CYTOKINE JI Cytokine PD APR 21 PY 2005 VL 30 IS 2 BP 86 EP 92 DI 10.1016/j.cyto.2004.12.009 PG 7 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA 917TJ UT WOS:000228491800006 PM 15804600 ER PT J AU Shearer, TW Kozar, MP O'Neil, MT Smith, PL Schiehser, GA Jacobus, DP Diaz, DS Yang, YS Milhous, WK Skillman, DR AF Shearer, TW Kozar, MP O'Neil, MT Smith, PL Schiehser, GA Jacobus, DP Diaz, DS Yang, YS Milhous, WK Skillman, DR TI In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID N-BENZYL-OXYDIHYDROTRIAZINES; PLASMODIUM-FALCIPARUM; DIHYDROFOLATE-REDUCTASE; ANTIFOLATE RESISTANCE; PYRIMETHAMINE; CYCLOGUANIL; WR99210; DHFR; MALARIA; INVITRO AB Phenoxypropoxybiguanides, such as 1 (PS-15), are prodrugs analogous to the relationship of proguanil and its active metabolite cycloguanil. Unlike cycloguanil, however, 1a (WR99210), the active metabolite of 1, has retained in vitro potency against newly emerging antifolate-resistant malaria parasites. Unfortunately, manufacturing processes and gastrointestinal intolerance have prevented the clinical development of 1. In vitro antimalarial. activity and in vitro metabolism studies have been performed on newly synthesized phenoxypropoxybiguanide analogues. All of the active dihydrotriazine metabolites exhibited potent antimalarial activity with in vitro IC50 values less than 0.04 ng/mL. In vitro metabolism studies in human liver microsomes identified the production of not only the active dihydrotriazine metabolite, but also a desalkylation on the carbonyl chain, and multiple hydroxylated metabolites. The V-max for production of the active metabolites ranged from 10.8 to 27.7 pmol/min/mg protein with the K-m ranging from 44.8 to 221 mu M. The results of these studies will be used to guide the selection of a lead candidate. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Jacobus Pharmaceut Co, Princeton, NJ 08540 USA. RP Shearer, TW (reprint author), Alcon Labs Inc, 6201 S Freeway, Ft Worth, TX 76134 USA. EM todd.shearer@alconlabs.com RI Kozar, Michael/A-9155-2011 NR 32 TC 19 Z9 20 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD APR 21 PY 2005 VL 48 IS 8 BP 2805 EP 2813 DI 10.1021/jm049683+ PG 9 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 917DH UT WOS:000228435700009 PM 15828818 ER PT J AU Stojadinovic, A Nissan, A Gallimidi, Z Lenington, S Logan, W Zuley, M Yeshaya, A Shimonov, M Melloul, M Fields, S Allweis, T Ginor, R Gur, D Shriver, CD AF Stojadinovic, A Nissan, A Gallimidi, Z Lenington, S Logan, W Zuley, M Yeshaya, A Shimonov, M Melloul, M Fields, S Allweis, T Ginor, R Gur, D Shriver, CD TI Electrical impedance scanning for the early detection of breast cancer in young women: Preliminary results of a multicenter prospective clinical trial SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID DETECTION DEMONSTRATION PROJECT; FOLLOW-UP; MAMMOGRAPHY; CARCINOMA; RISK; AGE; SPECTROSCOPY; BIOIMPEDANCE; ULTRASOUND; PROGNOSIS AB Purpose To evaluate the feasibility and patient satisfaction with electrical impedance scanning (EIS) for early detection of breast cancer in young women. Methods Women undergoing screening clinical breast examination, imaging, or biopsy were eligible for EIS examination with T-Scan 2000ED (Mirabel Medical Systems, Austin, TX). Multiple logistic regression analysis evaluated the association between clinical Variables and EIS performance. Patients completed a screening EIS satisfaction questionnaire (1 = least satisfied to 5 = most satisfied). Results Twenty-nine cancers were identified among 1,103 women. Sixty-six percent (19 of 29) of cancers were nonpalpable and 55% (16 of 29) were in women age <= 50 years. EIS sensitivity and specificity in women younger than 40 years was 50% and 90%, respectively. Exogenous estrogen use (P < .001) and menopausal status (P = .007) correlated significantly with EIS performance. False-positive rates were increased in postmenopausal women and those taking exogonous hormones. No correlation was evident between EIS performance and prior breast cancer, breast density, or palpability. EIS-positive women younger family history, than age 40 were 4.5 times more likely to have breast carcinoma than were women randomly selected from the general population. Patients were highly satisfied with the comfort, speed, and reporting of EIS, screening (mean score, 4.8). Conclusion EIS seems promising for early detection of breast cancer, and identification of young women at increased risk for having the disease at time of screening. Positive EIS-associated breast cancer risk compares favorably with relative risks of conditions commonly used to justify early breast cancer screening., Patients are satisfied with a screening paradigm involving breast EIS. C1 Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, Washington, DC 20237 USA. Hadassah Univ Hosp, Dept Surg, IL-91120 Jerusalem, Israel. Hadassah Univ Hosp, Dept Radiol, IL-91120 Jerusalem, Israel. Rambam Med Ctr, Dept Radiol, Haifa, Israel. Meir Hosp, Dept Nucl Med, Kefar Sava, Israel. Mirabel Med Syst, Austin, TX USA. Elizabeth Wende Breast Clin, Rochester, NY USA. Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA. Magee Womens Hosp, Pittsburgh, PA 15213 USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, 6900 Georgia Ave NW, Washington, DC 20237 USA. EM alexander.stojadinovic@na.amedd.army.mil NR 51 TC 54 Z9 59 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD APR 20 PY 2005 VL 23 IS 12 BP 2703 EP 2715 DI 10.1200/JCO.2005.06.155 PG 13 WC Oncology SC Oncology GA 918QV UT WOS:000228563600018 PM 15837985 ER PT J AU Mulhall, BP Veerappan, GR Jackson, JL AF Mulhall, BP Veerappan, GR Jackson, JL TI Meta-analysis: Computed tomographic colonography SO ANNALS OF INTERNAL MEDICINE LA English DT Review ID MULTISLICE CT COLONOGRAPHY; CONTRAST BARIUM ENEMA; COLORECTAL-CANCER; VIRTUAL COLONOSCOPY; CONVENTIONAL COLONOSCOPY; AVERAGE-RISK; DETECTION RATES; POLYPS; COLON; EXPERIENCE AB Background: Computed tomographic (CT) colonography, also called virtual colonoscopy, is an evolving technology under evaluation as a new method of screening for colorectal cancer. However, its performance as a test has varied widely across studies, and the reasons for these discrepancies are poorly defined. Purpose: To systematically review the test performance of CT colonography compared to colonoscopy or surgery and to assess variables that may affect test performance. Data Sources: The PubMed, MEDLINE, and EMBASE databases and the Cochrane Controlled Trials Register were searched for English-language articles published between January 1975 and February 2005. Study Selection: Prospective studies of adults undergoing CT colonography after full bowel preparation, with colonoscopy or surgery as the gold standard, were selected. Studies had to have used state-of-the-art technology, including at least a single-detector CT scanner with supine and prone positioning, insufflation of the colon with air or carbon dioxide, collimation smaller than 5 mm, and both 2-dimensional and 3-dimensional views during scan interpretation. The evaluators of the colonogram had to be unaware of the findings from use of the gold standard test. Data Abstraction: Data on sensitivity and specificity overall and for detection of polyps less than 6 mm, 6 to 9 mm, and greater than 9 mm in size were abstracted. Sensitivities and specificities weighted by sample size were calculated, and heterogeneity was explored by using stratified analyses and meta-regression. Data Synthesis: 33 studies provided data on 6393 patients. The sensitivity of CT colonography was heterogeneous but improved as polyp size increased (48% [95% Cl, 25% to 70%] for detection of polyps < 6 mm, 70% [Cl, 55% to 84%] for polyps 6 to 9 mm, and 85% [Cl, 79% to 91%] for polyps > 9 mm). Characteristics of the CT colonography scanner, including width of collimation, type of detector, and mode of imaging, explained some of this heterogeneity. In contrast, specificity was homogenous (92% [Cl, 89% to 96%] for detection of polyps < 6 mm, 93% [Cl, 91% to 95%] for polyps 6 to 9 mm, and 97% [Cl, 96% to 97%] for polyps > 9 mm). Limitations: The studies differed widely, and the extractable variables explained only a small amount of the heterogeneity. In addition, only a few studies examined the newest CT colonography technology. Conclusions: Computed tomographic colonography is highly specific, but the range of reported sensitivities is wide. Patient or scanner characteristics do not fully account for this variability, but collimation, type of scanner, and mode of imaging explain some of the discrepancy. This heterogeneity raises concerns about consistency of performance and about technical variability. These issues must be resolved before CT colonography can be advocated for generalized screening for colorectal cancer. C1 Walter Reed Army Med Ctr, Serv Gastroenterol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Washington, DC USA. RP Mulhall, BP (reprint author), Walter Reed Army Med Ctr, Serv Gastroenterol, 6900 Georgia Ave NW,Bldg 2,7F18, Washington, DC 20307 USA. EM brian.mulhall@na.amedd.army.mil NR 76 TC 222 Z9 234 U1 2 U2 13 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD APR 19 PY 2005 VL 142 IS 8 BP 635 EP 650 PG 16 WC Medicine, General & Internal SC General & Internal Medicine GA 916TZ UT WOS:000228410400007 PM 15838071 ER PT J AU Taylor, AJ Udelson, JE Reichek, N Fuster, V AF Taylor, AJ Udelson, JE Reichek, N Fuster, V TI Cardiac magnetic resonance imaging training - Reply SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Letter C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, WRAMC Bldg 2,Room 4A,6900 Georgia Ave NW, Washington, DC 20307 USA. EM allen.taylor@na.amedd.army.mil RI Fuster, Valentin/H-4319-2015 OI Fuster, Valentin/0000-0002-9043-9986 NR 1 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD APR 19 PY 2005 VL 45 IS 8 BP 1307 EP 1308 DI 10.1016/j.jacc.2005.01.009 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 916TY UT WOS:000228410300030 ER PT J AU Gregoratos, G AF Gregoratos, G TI Indications and recommendations for pacemaker therapy SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID BUNDLE-BRANCH BLOCK; ACUTE MYOCARDIAL-INFARCTION; CONGESTIVE-HEART-FAILURE; CAROTID-SINUS SYNDROME; LONG QT SYNDROME; TERM FOLLOW-UP; CARDIAC RESYNCHRONIZATION; INTRAVENTRICULAR BLOCK; CLINICAL-SIGNIFICANCE; BIFASCICULAR BLOCK AB Each year, pacemaker therapy is prescribed to approximately 900,000 persons worldwide. Current pacemaker devices treat bradyarrhythmias and tachyarrhythmias and, in some cases, are combined with, implantable defibrillators. In older patients, devices that maintain synchrony between atria and ventricles are preferred because they maintain the increased contribution of atrial contraction to ventricular filling necessary in this age group. In general, rate-responsive devices are preferred because they more closely simulate the physiologic function of the sinus node. Permanent pacemakers are implanted in adults primarily for the treatment of sinus node dysfunction, acquired atrioventricular block, and certain fascicular blocks. They also are effective in the prevention and treatment of certain tachyarrhythmias and forms of neurocardiogenic syncope. Biventricular pacing (resynchronization therapy) recently has been shown to be an effective treatment for advanced heart failure in patients with major intraventricular conduction effects, predominately left bundle branch block. Many studies have documented that pacemaker therapy can reduce symptoms, improve quality of life and, in certain patient populations, improve survival. C1 Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA. New York Med Coll, Valhalla, NY 10595 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Gregoratos, G (reprint author), Univ Calif San Francisco, Sch Med, 505 Parnassus Ave,M314, San Francisco, CA 94143 USA. EM gpoggrego@medicine.ucsf.edu NR 39 TC 7 Z9 9 U1 0 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD APR 15 PY 2005 VL 71 IS 8 BP 1563 EP 1570 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 918WV UT WOS:000228579300010 PM 15864898 ER PT J AU Cody, RB Laramee, JA Durst, HD AF Cody, RB Laramee, JA Durst, HD TI Versatile new ion source for the analysis of materials in open air under ambient conditions SO ANALYTICAL CHEMISTRY LA English DT Article ID IONIZATION MASS-SPECTROMETRY; ORGANIC-COMPOUNDS; ELECTROSPRAY-IONIZATION; PHOTOIONIZATION; NONVOLATILE AB A new ion source has been developed for rapid, noncontact analysis of materials at ambient pressure and at ground potential. The new source, termed DART (for "Direct Analysis in Real Time"), is based on the reactions of electronic or vibronic excited-state species with reagent molecules and polar or nonpolar analytes. DART has been installed on a high-resolution time-of-flight mass spectrometer (TOFMS) that provides improved selectivity and accurate elemental composition assignment through exact mass measurements. Although DART has been applied to the analysis of gases, liquids, and solids, a unique application is the direct detection of chemicals on surfaces without requiring sample preparation, such as wiping or solvent extraction. DART has demonstrated success in sampling hundreds of chemicals, including chemical agents and their signatures, pharmaceutics, metabolites, peptides and oligosaccharides, synthetic organics, organometallics, drugs of abuse, explosives, and toxic industrial chemicals. These species were detected on various surfaces, such as concrete, asphalt, human skin, currency, airline boarding passes, business cards, fruits, vegetables, spices, beverages, body fluids, horticultural leaves, cocktail glasses, and clothing. DART employs no radioactive components and is more versatile than devices using radioisotope-based ionization. Because its response is instantaneous, DART provides real-time information, a critical requirement for screening or high throughput. C1 JEOL USA Inc, Peabody, MA 01960 USA. EAI Corp, Abingdon, MD 21009 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Cody, RB (reprint author), JEOL USA Inc, 11 Dearborn Rd, Peabody, MA 01960 USA. EM cody@jeol.com NR 29 TC 1176 Z9 1231 U1 51 U2 476 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD APR 15 PY 2005 VL 77 IS 8 BP 2297 EP 2302 DI 10.1021/ac050162j PG 6 WC Chemistry, Analytical SC Chemistry GA 919FZ UT WOS:000228605100003 PM 15828760 ER PT J AU Vythilingam, M Scaramozza, M Nelson, EE Hazlett, G Waldeck, T Hadd, K Agarwal, R Drevets, WC Pine, DS Charney, DS Ernst, M AF Vythilingam, M Scaramozza, M Nelson, EE Hazlett, G Waldeck, T Hadd, K Agarwal, R Drevets, WC Pine, DS Charney, DS Ernst, M TI Resilient special forces soldiers have enhanced activation of reward related circuits SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 60th Annual Convention of the Society-of-Biological-Psychiatry CY MAY 19-21, 2005 CL Atlanta, GA SP Soc Biol Psychiat C1 NIMH, Mood & Anxiety Disorders Program, Bethesda, MD 20892 USA. John F Kennedy Special Warfare Training & Sch, Psychol Applicat Directorate, Ft Bragg, NC USA. Mt Sinai Sch Med, Deans Off, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD APR 15 PY 2005 VL 57 IS 8 SU S MA 375 BP 103S EP 104S PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 915VE UT WOS:000228338600366 ER PT J AU Arcari, CM Gaydos, CA Nieto, FJ Krauss, M Nelson, KE AF Arcari, CM Gaydos, CA Nieto, FJ Krauss, M Nelson, KE TI Association between Chlamydia pneumoniae and acute myocardial infarction in young men in the united states military: The importance of timing of exposure measurement SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID CORONARY-HEART-DISEASE; CYTOMEGALOVIRUS-INFECTION; ATHEROSCLEROSIS RISK; RABBIT MODEL; HEALTH; ARTERY; AZITHROMYCIN; METAANALYSIS; COMMUNITIES; TITERS AB Background. Several investigators have found that Chlamydia pneumoniae and cytomegalovirus infections may be risk factors for coronary heart disease. However, the data remain controversial. To address this hypothesis, data and specimens were collected from a well-established prospective cohort of active-duty personnel from the US military. Methods. A nested case-control study was conducted with 300 case patients and 300 matched control subjects. Case patients were men ( age, 30-50 years) with a medically documented, first-time hospitalization for acute myocardial infarction (MI) and from whom a serum specimen had been drawn >= 1 year before the time of the acute MI. Population-based control subjects were chosen from the same cohort and were individually matched by age, race, and time of specimen collection. Evidence of past infections with C. pneumoniae and cytomegalovirus were measured by microimmunofluorescence assay and enzyme-linked immunosorbent assay, respectively. Results. Significant risk was associated with high titer (>= 1: 64) to C. pneumoniae immunoglobulin A (IgA) ( adjusted relative risk [RRadj], 1.67; 95% confidence interval [CI], 1.04-2.70). This increased risk was greatest when specimens were collected 1-5 years before the event (RRadj, 2.11; 95% CI, 1.06-4.21). High titer (>= 1:256) to C. pneumoniae immunoglobulin G (IgG) was also associated with an elevated risk (RRadj, 1.74; 95% CI, 0.90-3.34) after full adjustment for cardiovascular risk factors, whereas no independent risk for acute MI was associated with cytomegalovirus IgG seropositivity. Conclusions. This study demonstrates a significant association between high titers to C. pneumoniae IgG and IgA and acute MI in a cohort of young men and suggests that recent or chronic active infections could be associated with an increased risk for MI. C1 Univ Wisconsin, Sch Med, Madison, WI 53706 USA. Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Arcari, CM (reprint author), 605 WARF,610 Walnut St, Madison, WI 53726 USA. EM carcari@wisc.edu RI Gaydos, Charlotte/E-9937-2010 NR 30 TC 25 Z9 27 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2005 VL 40 IS 8 BP 1123 EP 1130 DI 10.1086/428730 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 908WK UT WOS:000227820700008 PM 15791511 ER PT J AU Wortmann, G AF Wortmann, G TI Boiling the boil SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material ID CUTANEOUS LEISHMANIASIS; VISCERAL LEISHMANIASIS; GUATEMALA C1 Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Wortmann, G (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. EM glenn.wortmann@na.amedd.army.mil NR 14 TC 6 Z9 7 U1 1 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR 15 PY 2005 VL 40 IS 8 BP 1156 EP 1158 DI 10.1086/428738 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 908WK UT WOS:000227820700013 PM 15791516 ER PT J AU Chendorain, MD Stewart, LD Packer, B AF Chendorain, MD Stewart, LD Packer, B TI Corrosion of unexploded ordnance in soil - Field results SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article AB Unexploded ordnance (UXO) are found on 400 000 Ha of land across 1400 different sites in the United States. In many cases, UXO contain high explosives posing a risk to groundwater quality. This paper provides results from a field survey of 14 inactive Army ranges distributed throughout the mainland United States. Metal samples and adjacent soil were collected from 161 UXO. Soil samples were analyzed for a variety of chemical and physical properties. Metal samples were analyzed for pitting corrosion. Climate data were also compiled. Of these analyses, only rainfall correlated with extent of corrosion. Samples had been buried from the Civil War era through the 1990s. Photographs taken in the field illustrate that corrosion occurs more rapidly on the underside of a UXO. Field observations also revealed that low-order detonations and UXO are difficult to distinguish in the field. The deepest individual pit measured on any of the 161 metal samples was 2400 mu m. Low rainfall environments had shallower average pit depths (590 +/- 130 mu m)than moderate and high rainfall environments, which produced deeper average pit depths (940 +/- 90 mu m). The UXO studied in this effort were not a significant source of explosives to the unsaturated soil environment. C1 Praxis Environm Technol Inc, Burlingame, CA 94010 USA. USA, Ctr Environm, Aberdeen Proving Ground, MD 21010 USA. RP Chendorain, MD (reprint author), Praxis Environm Technol Inc, 1440 Rollins Rd, Burlingame, CA 94010 USA. EM chendo@praxis-enviro.com NR 9 TC 6 Z9 7 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 15 PY 2005 VL 39 IS 8 BP 2442 EP 2447 DI 10.1021/es049300x PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 917AT UT WOS:000228428900010 PM 15884333 ER PT J AU Millward, RN Bridges, TS Ghosh, U Zimmerman, JR Luthy, RG AF Millward, RN Bridges, TS Ghosh, U Zimmerman, JR Luthy, RG TI Addition of activated carbon to sediments to reduce PCB bioaccumulation by a polychaete (Neanthes arenaceodentata) and an amphipod (Leptocheirus plumulosus) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID POLYCYCLIC AROMATIC-HYDROCARBONS; DIGESTIVE FLUID EXTRACTION; POLYCHLORINATED-BIPHENYLS; ORGANIC-MATTER; PAH SPECIATION; BLACK CARBON; BIOAVAILABILITY; ADSORPTION; EQUILIBRIUM; SORPTION AB This work examines the effects of adding coke or activated carbon on the bioavailability of polychlorinated biphenyls (PCBs) in contaminated sediment from South Basin at Hunters Point, San Francisco Bay. We show with 28-day sediment exposure tests that PCB bioaccumulation in a polychaete (Neanthes arenaceodentata) is reduced by 82% following 1-month contact of sediment with activated carbon and by 87% following 6-months contact of sediment with activated carbon. PCB bioaccumulation in an amphipod (Leptocheirus plumulosus) is reduced by 70% following 1-month contact of sediment with activated carbon and by 75% after 6-months contact of sediment with activated carbon. Adding coke had a negligible effect on reducing PCB bioaccumulation, probably because of the low specific surface area and the slow kinetics of PCB diffusion into the solid coke particles. Reductions in congener bioaccumulation with activated carbon were inversely related to congener K-ow, suggesting that the efficacy of activated carbon is controlled by the mass-transfer rate of PCBs from sediment and into activated carbon. We find that reductions in aqueous PCB concentrations in equilibrium with the sediment were similar to reductions in PCB bioaccumulation. While no lethality was observed following activated carbon addition, growth rates were reduced by activated carbon for the polychaete, but not for the amphipod, suggesting the need for further study of the potential impacts of activated carbon on exposed communities. The study suggests that treatment of the biologically active layer of contaminated sediments with activated carbon may be a promising insitu technique for reducing the bioavailability of sediment associated PCBs and other hydrophobic organic compounds. C1 Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. Analyt Serv Inc, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. Univ Maryland, Dept Civil & Environm Engn, Baltimore, MD 21250 USA. RP Luthy, RG (reprint author), Stanford Univ, Dept Civil & Environm Engn, Terman M52, Stanford, CA 94305 USA. EM luthy@stanford.edu NR 38 TC 111 Z9 117 U1 3 U2 48 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 15 PY 2005 VL 39 IS 8 BP 2880 EP 2887 DI 10.1021/es048768x PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 917AT UT WOS:000228428900066 PM 15884389 ER PT J AU Doona, CJ Feeherry, FE Ross, EW AF Doona, CJ Feeherry, FE Ross, EW TI A quasi-chemical model for the growth and death of microorganisms in foods by non-thermal and high-pressure processing SO INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY LA English DT Article; Proceedings Paper CT 4th International Conference on Predictive Modelling in Foods CY JUN 15-19, 2003 CL Quimper, FRANCE SP Univ Bretagne Occidentale, LUMAQ, Technopole Quimper Cornouaille, ADRIA, Katholieke Univ Leuven, Dept Chem Engn, BioTeC, Conseil Reg Bretagne, Conseil Gen Finistere, Quimper Communaute, SIGMA PLUS DE quasi-chemical kinetics model; growth-death kinetics; predictive microbial modeling; high-pressure processing; Escherichia coli; Staphyloccocus aureus; Listeria monocytogenes ID STAPHYLOCOCCUS-AUREUS; KINETICS; BREAD AB Predictive microbial models generally rely on the growth of bacteria in laboratory broth to approximate the microbial growth kinetics expected to take place in actual foods under identical environmental conditions. Sigmoidal functions such as the Gompertz or logistics equation accurately model the typical microbial growth curve from the lag to the stationary phase and provide the mathematical 'basis for estimating parameters such as the maximum growth rate (MGR). Stationary phase data can begin to show a decline and make it difficult to discern which data to include in the analysis of the growth curve, a factor that influences the calculated values of the growth parameters. In contradistinction, the quasi-chemical kinetics model provides additional capabilities in microbial modelling and fits growth-death kinetics (all four phases of the microbial lifecycle continuously) for a general set of microorganisms in a variety of actual food substrates. The quasi-chemical model is differential equations (ODEs) that derives from a hypothetical four-step chemical mechanism involving an antagonistic metabolite (quorum sensing) and successfully fits the kinetics of pathogens (Staphylococcus aureus, Escherichia coli and Listeria monocytogenes) in various foods (bread, turkey meat, ham and cheese) as functions of different hurdles (a(w),pH, temperature and anti-microbial lactate). The calculated value of the MGR depends on whether growth-death data or only growth data are used in the fitting procedure. The quasi-chemical kinetics model is also exploited for use with the novel food processing technology of high-pressure processing. The high-pressure inactivation kinetics of E. coli are explored in a model food system over the pressure (P) range of 207-345 MPa (30,000-50,000 psi) and the temperature (T) range of 30-50 degrees C. In relatively low combinations of P and T, the inactivation curves are non-linear and exhibit a shoulder prior to a more rapid rate of microbial destruction. In the higher P, T regime, the inactivation plots tend to be linear. In all cases, the quasichemical model successfully fit the linear and curvi-linear inactivation plots for E. coli in model food systems. The experimental data and the quasi-chemical mathematical model described herein are candidates for inclusion in ComBase, the developing database that combines data and models from the USDA Pathogen Modeling Program and the UK Food MicroModel. Published by Elsevier B.V. C1 USA, RDECOM, Natick Soldier Ctr, Combat Feeding Innovat Sci Team, Natick, MA 01760 USA. RP Doona, CJ (reprint author), USA, RDECOM, Natick Soldier Ctr, Combat Feeding Innovat Sci Team, Kansas St, Natick, MA 01760 USA. EM Christopher.Doona@natick.army.mil NR 9 TC 32 Z9 32 U1 2 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1605 J9 INT J FOOD MICROBIOL JI Int. J. Food Microbiol. PD APR 15 PY 2005 VL 100 IS 1-3 BP 21 EP 32 DI 10.1016/j.ijfoodmicro.2004.10.005 PG 12 WC Food Science & Technology; Microbiology SC Food Science & Technology; Microbiology GA 926XM UT WOS:000229157000004 PM 15854689 ER PT J AU Schantz, PM Steurer, FJ Duprey, ZH Kurpel, KP Barr, SC Jackson, JE Breitschwerdt, EB Levy, MG Fox, JC AF Schantz, PM Steurer, FJ Duprey, ZH Kurpel, KP Barr, SC Jackson, JE Breitschwerdt, EB Levy, MG Fox, JC TI Autochthonous visceral leishmaniasis in dogs in North America SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article ID PHLEBOTOMINE SAND FLIES; CONGENITAL KALA-AZAR; CANINE LEISHMANIASIS; EXPERIMENTAL TRANSMISSION; CUTANEOUS LEISHMANIASIS; UNITED-STATES; TEXAS; PSYCHODIDAE; DIPTERA; EPIDEMIOLOGY C1 Ctr Dis Control, Natl Ctr Infect Dis, Div Parasit Dis, Atlanta, GA 30341 USA. Cornell Univ, Coll Vet Med, Dept Clin Sci, Ithaca, NY 14853 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. N Carolina State Univ, Coll Vet Med, Raleigh, NC 27603 USA. Oklahoma State Univ, Coll Vet Med, Stillwater, OK 74078 USA. RP Schantz, PM (reprint author), Ctr Dis Control, Natl Ctr Infect Dis, Div Parasit Dis, 4770 Buford Hwy, Atlanta, GA 30341 USA. NR 46 TC 41 Z9 41 U1 0 U2 6 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA SN 0003-1488 J9 JAVMA-J AM VET MED A JI JAVMA-J. Am. Vet. Med. Assoc. PD APR 15 PY 2005 VL 226 IS 8 BP 1316 EP 1322 DI 10.2460/javma.2005.226.1316 PG 7 WC Veterinary Sciences SC Veterinary Sciences GA 915XT UT WOS:000228345600023 PM 15844420 ER PT J AU Gourevitch, A Laikhtman, B Westerfeld, D Donetsky, D Belenky, G Trussell, CW Shellenbarger, Z An, H Martinelli, RU AF Gourevitch, A Laikhtman, B Westerfeld, D Donetsky, D Belenky, G Trussell, CW Shellenbarger, Z An, H Martinelli, RU TI Transient thermal analysis of InGaAsP-InP high-power diode laser arrays with different fill factors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MU-M; OPERATION; BEHAVIOR AB The temperature kinetics of InGaAsP/InP high-power laser diode arrays with different fill factors was studied experimentally and theoretically. It was shown that except during a short initial period, the laser array heating is determined by the heat flux propagation through the heat spreader. To characterize this heating, we developed a two-dimensional analytical model. Experimentally, the temperature change in the active region was obtained by measuring the laser spectrum's temporal evolution during a single current pulse. Three distinctive periods in the transient heating process were clearly identified-an initial temperature rise, a square-root-of-time dependence of the active-region temperature increase, and an exponential approach of the active-region temperature to its steady-state value. We demonstrated that in the initial period of time, the heat propagates within the laser bar structure, and the laser bar design (fill factor) strongly affects the active-region temperature rise. In the later periods the temperature kinetics is insensitive to the fill factor. (C) 2005 American Institute of Physics. C1 SUNY Stony Brook, Stony Brook, NY 11794 USA. Power Photon, Stony Brook, NY 11794 USA. USA, Nevada & Environm & Safety Directorate, Ft Belvoir, VA 22060 USA. Sarnoff Corp, Princeton, NJ 08543 USA. Hebrew Univ Jerusalem, Racah Inst Phys, IL-91904 Jerusalem, Israel. RP Gourevitch, A (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA. EM gourevitch@ece.sunysb.edu NR 20 TC 7 Z9 9 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 15 PY 2005 VL 97 IS 8 AR 084503 DI 10.1063/1.1884251 PG 6 WC Physics, Applied SC Physics GA 920XT UT WOS:000228729500109 ER PT J AU Chernetsova, ES Revelsky, AI Durst, D Sobolevsky, TG Revelsky, IA AF Chernetsova, ES Revelsky, AI Durst, D Sobolevsky, TG Revelsky, IA TI Increasing the accuracy of determination of n(C)/n(H) ratios by gas chromatography-atomic emission detection SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article; Proceedings Paper CT 27th International Symposium on Capillary Chromatography CY MAY 31-JUN 04, 2004 CL Riva del Garda, ITALY DE gas chromatography-atomic emission detection; n(C)/n(H) ratios; aliphatic hydrocarbons AB The influence of oxygen content in helium on the accuracy of n(C)/n(H) ratio determination for model mixtures of aliphatic and polyaromatic hydrocarbons and polychlorinated biphenyls was studied. The best accuracy was achieved at the oxygen content ca. 9%, which was the maximal possible oxygen content in helium for this GC-atomic emission detection (helium flow rate was 25 ml min(-1)). Using the maximal oxygen flow in plasma the n(C)/n(H) ratio determination accuracy improvement was accompanied by 10-fold increase in detection limit. (c) 2004 Elsevier B.V. All rights reserved. C1 Moscow MV Lomonosov State Univ, Dept Chem, Div Analyt Chem, Moscow 119992, Russia. USA, Edgewood Labs, Aberdeen Proving Ground, MD USA. RP Chernetsova, ES (reprint author), Moscow MV Lomonosov State Univ, Dept Chem, Div Analyt Chem, Leninskie Gory 1 Bldg 3, Moscow 119992, Russia. EM chernetsova@environment.chem.msu.ru NR 9 TC 1 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD APR 15 PY 2005 VL 1071 IS 1-2 BP 55 EP 58 DI 10.1016/j.chroma.2004.09.021 PG 4 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 916QS UT WOS:000228401300008 PM 15865173 ER PT J AU DaCunha, JJ AF DaCunha, JJ TI Stability for time varying linear dynamic systems on time scales SO JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS LA English DT Article DE stability; time scale; Lyapunov; time varying; linear system; slowly varying; continuous; discrete AB We study conditions under which the solutions of a time varying linear dynamic system of the form x(Delta)(t)=A(t)x(i) are stable on certain time scales. We give sufficient conditions for various types of stability, including Lyapunov-type stability criteria and eigenvalue conditions on "slowly varying" systems that ensure exponential stability. Finally, perturbations of the unforced system are investigated, and an instability criterion is also developed. (C) 2004 Elsevier B.V. All rights reserved. C1 US Mil Acad, Dept Math, W Point, NY 10996 USA. RP DaCunha, JJ (reprint author), US Mil Acad, Dept Math, W Point, NY 10996 USA. EM jeffrey.dacunha@usma.edu NR 27 TC 60 Z9 63 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-0427 J9 J COMPUT APPL MATH JI J. Comput. Appl. Math. PD APR 15 PY 2005 VL 176 IS 2 BP 381 EP 410 DI 10.1016/j.cam.2004.07.026 PG 30 WC Mathematics, Applied SC Mathematics GA 888UF UT WOS:000226399000010 ER PT J AU Wright, S Pellegrino, J Amy, G Ranville, JL AF Wright, S Pellegrino, J Amy, G Ranville, JL TI Towards development of a surrogate aqueous mixture for studying flux decline characteristics of membranes and membrane processes SO JOURNAL OF MEMBRANE SCIENCE LA English DT Article DE characterization; colloids; flux decline; whey proteins; silica sol; ultrafiltration ID COLLOIDS; WATER AB A synthetic mixture of solutes (colloids, macromolecules, small organic molecules, and salts) was evaluated to facilitate consistent bench and small pilot-scale studies of membrane flux decline. In this paper, we present physical, chemical, and filtration resistance properties of inexpensive, commercial, off-the-shelf components -colloidal silica and dried whey protein in pH-buffered aqueous electrolyte solution - that we used to investigate membrane flux decline with ultrafiltration membranes. We also include some comparisons of their properties with those reported in the literature for natural waters. Our data shows that these synthetic components have many comparable physical and chemical properties as the constituents of natural waters. These results suggest that a well-characterized "surrogate" mixture for natural waters can be used for ongoing studies of membrane and membrane process performance and remove ambiguities that can result from seasonal, geographical, and storage-related variations in natural waters. Thus, the use of a surrogate mixture facilitates equitable comparisons among materials, equipment, and processes which would assure better-informed engineering decisions. (c) 2005 Elsevier B.V. All rights reserved. C1 Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. USA, APO, AP USA. Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. NIST, Phys & Chem Properties Div, Boulder, CO 80309 USA. RP Pellegrino, J (reprint author), Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. EM john.pellegrino@colorado.edu RI Ranville, James/H-1428-2011; OI PELLEGRINO, JOHN/0000-0001-7749-5003 NR 16 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0376-7388 J9 J MEMBRANE SCI JI J. Membr. Sci. PD APR 15 PY 2005 VL 252 IS 1-2 BP 205 EP 214 DI 10.1016/j.memsci.2004.12.010 PG 10 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA 922PS UT WOS:000228850700020 ER PT J AU La Scala, JJ Orlicki, JA Winston, C Robinette, EJ Sands, JM Palmese, GR AF La Scala, JJ Orlicki, JA Winston, C Robinette, EJ Sands, JM Palmese, GR TI The use of bimodal blends of vinyl ester monomers to improve resin processing and toughen polymer properties SO POLYMER LA English DT Article DE low VOC vinyl esters; viscosity; toughness ID CURE KINETICS; EPOXY-RESINS AB Vinyl ester (VE) monomers with bimodal molecular weight distributions were prepared by reacting methacrylic acid with blends of monodisperse epoxy resins ranging in molecular weight from 350-7000 g/mol. Monodisperse vinyl ester monomers were prepared from epoxy resins of a single molecular weight. The extent of vinyl ester formation was found to be near complete and side reactions, such as etherification, did not occur to a significant extent. The viscosities of these vinyl ester resins were measured as a function of styrene content. It was found that resin viscosity, eta, increased exponentially and predictably as both the styrene content (S) decreased and as the number average molecular weight (M-n) of the vinyl ester monomers increased: eta similar to exp(M-n)/exp(S). Cure kinetics studies showed that the vinyl ester reactivity ratio decreased to 0.1 from 0.6 for bimodal blends relative to monodisperse resins while the styrene reactivity ratio increased from 0.4 to 0.6. Thus, the microgels in bimodal blends were smaller than in monodisperse resins. Emissions studies proved that decreasing the styrene content reduced the VOC emission rate and total emissions. Higher VE molecular weights decreased the overall emissions due to a reduction in monomer mobility. T-g decreased from 143 to 125 degrees C as M-n of the VE monomers increased from 540 to 920 g/mol; yet, T-g of these bimodal blends were still equal to or greater than that of commercial VE resins (similar to 125 degrees C). The fracture toughness of bimodal blends increased from similar to 100 to similar to 330 J/m(2) as VE M-n increased from 540 to 920 g/mol because of matrix toughening. The fracture properties did not improve as the styrene content increased from 35 to 45 wt% because of corresponding changes in the morphology. Yet, there were numerous low VOC bimodal formulations with fracture properties in excess of the low VOC Dow Derakane 441-400 (110 J/m(2)) and even the industry standard Derakane 411-350 (240 J/m(2)). (c) 2005 Elsevier Ltd. All rights reserved. C1 Drexel Univ, Dept Chem Engn, Philadelphia, PA 19104 USA. USA, Res Labs, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem Engn, Philadelphia, PA 19104 USA. EM palmese@coe.drexel.edu NR 39 TC 34 Z9 34 U1 0 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD APR 15 PY 2005 VL 46 IS 9 BP 2908 EP 2921 DI 10.1016/j.polymer.2005.02.011 PG 14 WC Polymer Science SC Polymer Science GA 915PA UT WOS:000228315100011 ER PT J AU Li, C Lee, JS Groebner, JL Kim, HC Klein, TA O'Guinn, ML Wilkerson, RC AF Li, C Lee, JS Groebner, JL Kim, HC Klein, TA O'Guinn, ML Wilkerson, RC TI A newly recognized species in the Anopheles Hyrcanus Group and molecular identification of related species from the Republic of South Korea (Diptera : Culicidae) SO ZOOTAXA LA English DT Article DE malaria; Anopheles; PCR identification; Hyrcanus Group; South Korea AB We report here a previously unrecognized mosquito species from the Republic of South Korea that is closely related to Anopheles (Anopheles) sinensis. We also present an rDNA ITS2-based method for identification of this and the other morphologically similar Anopheles from the country. The PCR assay is a multiplex of seven primers in a single reaction that unambiguously identifies all included species. The other species include An. sinensis, An. lesteri, An. pullus, and a previously reported unknown Anopheles. Based on the ITS2 sequence, the two unnamed species have genetic distances from An. sinensis of 9.1% (unknown 1) and 10.7% (unknown 2), and are 10.6% different from each other. Adult females of An. sinensis and unknown 2 are morphologically indistinguishable, while unknown 1, An. lesteri and An. pullus can usually be separated from each other and from An. sinensis using available keys and descriptions. This PCR identification tool offers vector biologists and malaria epidemiologists a means to identify the potential vectors of malaria parasites in South Korea. C1 Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. USA, APO, AP 96205 USA. 18th MEDCOM, Unit 15281, APO, AP 96205 USA. RP Li, C (reprint author), Walter Reed Army Inst Res, Dept Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM wilkersonr@msc.si.edu RI Valle, Ruben/A-7512-2013; OI Groebner, Jennifer/0000-0003-1503-5030 NR 9 TC 51 Z9 54 U1 1 U2 1 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD APR 15 PY 2005 IS 939 BP 1 EP 8 PG 8 WC Zoology SC Zoology GA 918DA UT WOS:000228518400001 ER PT J AU Rueda, LM AF Rueda, LM TI Two new species of Anopheles (Anopheles) Hyrcanus Group (Diptera : Culicidae) from the Republic of South Korea SO ZOOTAXA LA English DT Article DE Anopheles belenrae; kleini; Culicidae; taxonomy; description; mosquitoes; Hyrcanus Group ID GENUS ANOPHELES AB Two new mosquito species belonging to the Hyrcanus Group, Anopheles (Anopheles) belenrae Rueda and An. (Ano.) kleini Rueda, are described from the Republic of South Korea, with illustrations of the larvae, pupae, adults, and male genitalia. C1 Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. RP Rueda, LM (reprint author), Smithsonian Inst, Museum Support Ctr, Walter Reed Biosystemat Unit, 4210 Silver Hill Rd, Suitland, MD 20746 USA. EM ruedapol@si.edu NR 15 TC 42 Z9 52 U1 1 U2 1 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD APR 15 PY 2005 IS 941 BP 1 EP 26 PG 26 WC Zoology SC Zoology GA 918DC UT WOS:000228518600001 ER PT J AU Rupprecht, CE Gibbons, RV AF Rupprecht, CE Gibbons, RV TI Prophylaxis against rabies - Reply SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Rupprecht, CE (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM cyr5@cdc.gov NR 3 TC 0 Z9 0 U1 0 U2 1 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 14 PY 2005 VL 352 IS 15 BP 1609 EP 1610 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 915SH UT WOS:000228324200033 ER PT J AU Hepburn, MJ Vos, JA Fillman, EP Lawitz, EJ AF Hepburn, MJ Vos, JA Fillman, EP Lawitz, EJ TI The accuracy of the report of hepatic steatosis on ultrasonography in patients infected with hepatitis C in a clinical setting: A retrospective observational study SO BMC GASTROENTEROLOGY LA English DT Article ID FATTY LIVER-DISEASE; VIRUS-INFECTION; CORE PROTEIN; FIBROSIS; HISTOLOGY; BIOPSY AB Background: Steatosis is occasionally reported during screening ultrasonography in patients with hepatitis C virus (HCV). We conducted a retrospective observational study to assess the factors associated with steatosis on ultrasonography and the relationship between steatosis on ultrasound versus biopsy in patients infected with HCV in a clinical setting. Our hypothesis was ultrasonography would perform poorly for the detection of steatosis outside of the context of a controlled study, primarily due to false-positive results caused by hepatic fibrosis and inflammation. Methods: A retrospective review of ultrasound reports was conducted on patients infected with HCV in a tertiary care gastroenterology clinic. Reports were reviewed for the specific documentation of the presence of steatosis. Baseline clinical and histologic parameters were recorded, and compared for patients with vs. without steatosis. Multiple logistic regression analysis was performed on these baseline variables. Liver biopsies were reviewed by two pathologists, and graded for steatosis. Steatosis on biopsy was compared to steatosis on ultrasound report, and the performance characteristics of ultrasonography were calculated, using biopsy as the gold standard. Results: Ultrasound reports were available on 164 patients. Patients with steatosis on ultrasound had a higher incidence of the following parameters compared to patients without steatosis: diabetes (12/49 [24%] vs. 7/115 [6%], p < 0.001), fibrosis stage > 2 (15/48 [31%] vs. 16/110 [15%], p = 0.02), histologic grade > 2 (19/48 [40%] vs. 17/103 [17%], p = 0.002), and ALT (129.5 +/- 89.0 IU/L vs. 94.3 +/- 87.0 IU/L, p = 0.01). Histologic grade was the only factor independently associated with steatosis with multivariate analysis. When compared to the histologic diagnosis of steatosis (n = 122), ultrasonography had a substantial number of false-positive and false-negative results. In patients with a normal ultrasound, 8/82 (10%) had > 30% steatosis on biopsy. Among patients with steatosis reported on ultrasound, only 12/40 (30%) had > 30% steatosis on biopsy review. Conclusion: Steatosis on ultrasound is associated with markers of inflammation and fibrosis in HCV-infected patients, but does not consistently correlate with steatosis on biopsy outside of the context of a controlled study. Clinicians should be skeptical of the definitive diagnosis of steatosis on hepatic ultrasonography. C1 Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. RP Hepburn, MJ (reprint author), Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. EM matthew.hepburn@us.army.mil; jeffrey.vos@amedd.army.mil; eric.fillman@amedd.army.mil; lawitz@alamomedicalresearch.com NR 24 TC 40 Z9 41 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-230X J9 BMC GASTROENTEROL JI BMC Gastroenterol. PD APR 13 PY 2005 VL 5 AR 14 DI 10.1186/1471-230X-5-14 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 922FF UT WOS:000228821200001 PM 15829009 ER PT J AU Marshall, D Walizer, E Jackson, HM Vernalis, M AF Marshall, D Walizer, E Jackson, HM Vernalis, M TI Therapeutic lifestyle change: An alternative to high-dose statins for achieving new low density lipoprotein cholesterol goals SO CIRCULATION LA English DT Meeting Abstract CT 45th Annual Conference on Cardiovascular Disease Epidemiology and Prevention CY APR 29-MAY 02, 2005 CL Washington, DC SP Amer Heart Assoc, Council Epidemiol & Prevent & Nutr Phys Activity & Met, Natl Heart Lung & Blood Inst C1 Henry M Jackson Fdn, Rockville, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD APR 12 PY 2005 VL 111 IS 14 MA P130 BP E212 EP E212 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 915EO UT WOS:000228280900156 ER PT J AU Karakaya, P Sidhoum, M Christodoulatos, C Nicolich, S Balas, W AF Karakaya, P Sidhoum, M Christodoulatos, C Nicolich, S Balas, W TI Aqueous solubility and alkaline hydrolysis of the novel high explosive hexanitrohexaazaisowurtzitane (CL-20) SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE CL-20; HNIW; solubility; alkaline hydrolysis; kinetics ID PLASTIC-BONDED EXPLOSIVES; BASE HYDROLYSIS; HMX; KINETICS; RDX; 1,3,5,7-TETRAAZA-1,3,5,7-TETRANITROCYCLOOCTANE; 1,3,5-TRIAZA-1,3,5-TRINITROCYCLOHEXANE AB The recently developed polycyclic nitramine CL-20 is considered as a possible replacement for the monocyclic nitramines RDX and HMX. The present study reports aqueous solubility data for CL-20, as well as the kinetic parameters for its alkaline hydrolysis with sodium hydroxide below and above its solubility limits. Aqueous solubility of CL-20 was measured in the temperature range of 4-69 degrees C and the data were fitted to a generalized solubility model. Alkaline hydrolysis experiments were conducted at 15, 20, 30 and 40 degrees C, with hydroxide concentrations ranging from 0.25 to 300 mM. Like RDX and HMX, alkaline hydrolysis of CL-20 follows second-order kinetics. CL-20 alkaline hydrolysis was found to proceed at a significantly faster rate than RDX. The temperature dependency of the second-order rate constants was evaluated using the Arrhenius model. The activation energy for CL-20 was found to be within close range of the activation energies reported for RDX and HMX. (c) 2005 Elsevier B.V. All rights reserved. C1 Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. USA, TACOM, ARDEC, Energet & Warheads Div, Picatinny Arsenal, NJ 07806 USA. RP Sidhoum, M (reprint author), Stevens Inst Technol, Ctr Environm Syst, Castle Point Hudson, Hoboken, NJ 07030 USA. EM msidhoum@stevens.edu NR 25 TC 23 Z9 23 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD APR 11 PY 2005 VL 120 IS 1-3 BP 183 EP 191 DI 10.1016/j.jhazmat.2005.01.001 PG 9 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 920EM UT WOS:000228672200024 PM 15811680 ER PT J AU Sliney, D Aron-Rosa, D DeLori, F Fankhauser, F Landry, R Mainster, M Marshall, J Rassow, B Stuck, B Trokel, S West, TM Wolffe, M AF Sliney, D Aron-Rosa, D DeLori, F Fankhauser, F Landry, R Mainster, M Marshall, J Rassow, B Stuck, B Trokel, S West, TM Wolffe, M TI Adjustment of guidelines for exposure of the eye to optical radiation from ocular instruments: statement from a task group of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT Biomedical Topical Meeting CY APR 01-10, 2005 CL Miami Beach, FL SP Opt Soc Amer ID LIGHT-SOURCES; UV-RADIATION; DAMAGE; HAZARDS; LIMITS; PHOTOTOXICITY; LENS; NM AB A variety of optical and electro-optical instruments are used for both diagnostic and therapeutic applications to the human eye. These generally expose ocular structures to either coherent or incoherent optical radiation (ultraviolet, visible, or infrared radiation) under unique conditions. We convert both laser and incoherent exposure guidelines derived for normal exposure conditions to the application of ophthalmic sources. (c) 2005 Optical Society of America. C1 ICNIRP, D-85764 Oberschleissheim, Germany. USA, Ctr Hlth Promot & Prevent Med, Laser Opt Radiat Program, Aberdeen Proving Ground, MD 21010 USA. RP Sliney, D (reprint author), ICNIRP, Ingolstaedter Landstr 1, D-85764 Oberschleissheim, Germany. EM david.sliney@apg.amedd.army.mil NR 31 TC 50 Z9 53 U1 0 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD APR 10 PY 2005 VL 44 IS 11 BP 2162 EP 2176 DI 10.1364/AO.44.002162 PG 15 WC Optics SC Optics GA 917JT UT WOS:000228457800017 PM 15835362 ER PT J AU Silton, SI Goldstein, DB AF Silton, SI Goldstein, DB TI Use of an axial nose-tip cavity for delaying ablation onset in hypersonic flow SO JOURNAL OF FLUID MECHANICS LA English DT Article ID FORWARD-FACING CAVITY AB A forward-facing cavity is examined as a means of reducing the severe heating and delaying ablation onset at the nose-tip of a hypersonic vehicle. Whereas previous studies have concentrated on the nature of flow-induced Hartmann-whistle oscillations or on heating rates alone, the present study addresses the effect of the cavity on ablation onset times through experiments and coupled flow field/heat conduction simulation. Using our previously developed experimental technique, a parametric study is undertaken to optimize the forward-facing cavity geometry for the most delayed ablation onset. The geometric parameters of cavity length, lip radius and diameter are independently optimized for a given nose-tip diameter. Then using benchmarked linked flow field/heat conduction simulations, numerical simulations are conducted for each parametrically optimized configuration in order to investigate the flow physics. The impact of the forward-facing cavity on aerodynamic drag is also considered. C1 Univ Texas, Dept Aerosp Engn & Engn Mech, Austin, TX 78712 USA. RP Silton, SI (reprint author), USA, Res Lab, AMSRD, ARL,WM,BC, Aberdeen Proving Ground, MD 21005 USA. NR 27 TC 15 Z9 16 U1 1 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD APR 10 PY 2005 VL 528 BP 297 EP 321 DI 10.1017/S0022112004002460 PG 25 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA 921NH UT WOS:000228770800013 ER PT J AU Gladczuk, L Patel, A Demaree, JD Sosnowski, M AF Gladczuk, L Patel, A Demaree, JD Sosnowski, M TI Sputter deposition of bcc tantalum films with TaN underlayers for protection of steel SO THIN SOLID FILMS LA English DT Article DE physical vapor deposition; tantalum; tantalum nitride; magnetron sputtering ID PHASE-TRANSFORMATION; JOSEPHSON-JUNCTIONS; BETA-TANTALUM; THIN-FILMS; MICROSTRUCTURE; BARRIER; GROWTH; METAL; LAYER AB Deposition of tantalum films for protective coatings on steel has been investigated. The desired tough and ductile bcc phase of tantalum, rather than the normally deposited hard and brittle tetragonal phase, has been grown by DC magnetron sputtering on unheated substrates first covered with thin layers of tantalum nitride. The nitride was formed by reactive sputtering with nitrogen gas, with the same DC magnetron source and target as used for deposition of tantalum. The crystal structure and composition of the nitride promoting the growth of bcc Ta, previously undefined, has been identified as the metastable fcc (NaCl like) TaN. Alignment of the (111) crystallographic planes of fec TAN with (110) planes of bcc Ta is discussed as a possible mechanism for this effect. The minimum thickness of TaN underlayer on steel, required to promote the growth of bcc Ta, has been established and found to be dependent on the substrate surface preparation. Scratch tests with a diamond tip showed that the nitride underlayer does not compromise the film adhesion. Stable and well-adhering coatings of bcc Ta with thickness ranging from tens of nanometers to tens of micrometers on steel with a thin TaN underlayer were obtained. The process of deposition of bcc Ta films, including the formation of TAN underlayers is described in detail. (c) 2004 Elsevier B.V. All rights reserved. C1 New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. EM sosnowski@njit.edu NR 26 TC 40 Z9 41 U1 2 U2 26 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD APR 8 PY 2005 VL 476 IS 2 BP 295 EP 302 DI 10.1016/j.tsf.2004.10.020 PG 8 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 905PO UT WOS:000227581600012 ER PT J AU Geiger, CA Drinkwater, MR AF Geiger, CA Drinkwater, MR TI Coincident buoy- and SAR-derived surface fluxes in the western Weddell Sea during Ice Station Weddell 1992 SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID APERTURE RADAR DATA; BOTTOM WATER; COASTAL POLYNYAS; HEAT-FLUX; DEFORMATION; OCEAN; TIDES; DRIFT; ANTARCTICA; MODELS AB We examine sea ice kinematics relevant to surface fluxes using ERS-1 synthetic aperture radar (SAR) images coincident with buoys in the western Weddell Sea in austral autumn of 1992. Careful matching of temporal and spatial scales shows that buoy- and SAR-derived velocities differ in root-mean-square error (RMSE) by 0.6 cm s(-1) and 7.80 degrees in magnitude and direction, respectively. These values represent agreements of 91.3% and 92.7%, respectively, and correspond to instrument uncertainties. Scaling analysis shows that shear matching is best at the smallest scales (<= 5 km), while divergence is better represented at scales of 40 km and larger. Sensitivity to error propagation shows lower agreement for divergence (47.4%; RMSE = 7.46 x 10-(8) s(-1)), but we find these results sufficient for integrated surface flux comparisons. Using a toy model, we test the effects of aliasing in surface flux determination. The results show that variability associated with storms, ocean tides, inertial oscillations, and other high-frequency forcing affects integrated sea ice growth rates along this continental slope location. Integrated salt and new ice production rates computed from buoys are found to be two times larger than those computed from ERS-1 SAR motion products. We show that these differences in salt and ice production rates result primarily from inadequate temporal resolution of heat flux variability and sea ice divergence. Comparison with other studies shows that the problem is widespread, thereby impacting the modeling of sea ice mass balance and variability. The small-scale processes cited here have significant ramifications for larger scales and the global thermohaline circulation. C1 Univ Delaware, Ctr Climat Res, Newark, DE USA. European Space Agcy, European Space Res & Technol Ctr, Sci & Applicat Dept, Earth Observat Programmes,Oceans Ice Unit, NL-2200 AG Noordwijk, Netherlands. RP Geiger, CA (reprint author), Environm Res & Dev Ctr, Cold Reg Res & Engn Lab, Snow & Ice Branch, 72 Lyme Rd, Hanover, NH 03755 USA. EM cathleen.a.geiger@erdc.usace.army.mil; mark.drinkwater@esa.int OI Drinkwater, Mark/0000-0002-9250-3806 NR 56 TC 19 Z9 19 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD APR 7 PY 2005 VL 110 IS C4 AR C04002 DI 10.1029/2003JC002112 PG 17 WC Oceanography SC Oceanography GA 916IS UT WOS:000228379200001 ER PT J AU Taylor, AJ AF Taylor, AJ TI ARBITER 2: A double-blind, placebo-controlled study of long-acting niacin on atherosclerosis progression in secondary prevention patients treated with statins SO CIRCULATION LA English DT Meeting Abstract CT 77th Scientific Meeting of the American-Heart-Association CY NOV 07-10, 2004 CL New Orleans, LA SP Amer Heart Assoc C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD APR 5 PY 2005 VL 111 IS 13 BP 1727 EP 1727 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 913CZ UT WOS:000228129900064 ER PT J AU Day, JW Barras, J Clairain, E Johnston, J Justic, D Kemp, GP Ko, JY Lane, R Mitsch, WJ Steyer, G Templet, P Yanez-Arancibia, A AF Day, JW Barras, J Clairain, E Johnston, J Justic, D Kemp, GP Ko, JY Lane, R Mitsch, WJ Steyer, G Templet, P Yanez-Arancibia, A TI Implications of global climatic change and energy cost and availability for the restoration of the Mississippi delta SO ECOLOGICAL ENGINEERING LA English DT Article; Proceedings Paper CT Wetlands Invitational Workshop CY MAY 15-16, 2003 CL Ohio State Univ, Columbus, OH HO Ohio State Univ DE Mississippi delta; salinity intrusion; climate change; energy ID GULF-OF-MEXICO; SEA-LEVEL RISE; BARRIER-ISLAND; LOUISIANA COAST; WATER-QUALITY; VERTICAL ACCRETION; ATCHAFALAYA RIVER; PLANT COMMUNITY; SALT-MARSH; LAND LOSS AB Over the past several thousand years, inputs from the Mississippi River formed the Mississippi delta, an area of about 25,000 km(2). Over the past century, however, there has been a high loss of coastal wetlands of about 4800 km(2). The main causes of this loss are the near complete isolation of the river from the delta, mostly due to the construction of flood control levees, and pervasive hydrological disruption of the deltaic plain. There is presently a large-scale State-Federal program to restore the delta that includes construction of water control structures in the flood control levees to divert river water into deteriorating wetlands and pumping of dredged sediment, often for long distances, for marsh creation. Global climate change and decreasing availability and increasing cost of energy are likely to have important implications for delta restoration. Coastal restoration efforts will have to be more intensive to offset the impacts of climate change including accelerated sea level rise and changes in precipitation patterns. Future coastal restoration efforts should also focus on less energy-intensive, ecologically engineered management techniques that use the energies of nature as much as possible. Diversions may be as important for controlling salinity as for providing sediments and nutrients for restoring coastal wetlands. Energy-intensive pumping-dredged sediments for coastal restoration will likely become much more expensive in the future. (c) 2005 Elsevier B.V. All rights reserved. C1 Louisiana State Univ, Sch Coast & Environm, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA. Louisiana State Univ, Sch Coast & Environm, Coastal Ecol Inst, Baton Rouge, LA 70803 USA. Louisiana State Univ, Dept Environm Studies, Sch Coast & Environm, Baton Rouge, LA 70803 USA. US Geol Survey, Natl Wetlands Res Ctr, Baton Rouge, LA 70894 USA. USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. Ohio State Univ, Sch Nat Resources, Olentangy River Wetland Res Pk, Columbus, OH 43202 USA. Inst Ecol AC, Coastal Ecosyst Unit, Xalapa, Veracruz, Mexico. RP Louisiana State Univ, Sch Coast & Environm, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA. EM johnday@lsu.edu NR 71 TC 53 Z9 56 U1 8 U2 44 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-8574 EI 1872-6992 J9 ECOL ENG JI Ecol. Eng. PD APR 5 PY 2005 VL 24 IS 4 BP 253 EP 265 DI 10.1016/j.ecoleng.2004.11.015 PG 13 WC Ecology; Engineering, Environmental; Environmental Sciences SC Environmental Sciences & Ecology; Engineering GA 940ZI UT WOS:000230184000002 ER PT J AU Yao, P Schneider, GJ Prather, DW Wetzel, ED O'Brien, DJ AF Yao, P Schneider, GJ Prather, DW Wetzel, ED O'Brien, DJ TI Fabrication of three-dimensional photonic crystals with multilayer photolithography SO OPTICS EXPRESS LA English DT Article ID LITHOGRAPHY AB We have developed a new approach for the fabrication of three-dimensional (3D) photonic crystals based on multilayer 3D photolithography. This method, which uses commercially available photoresist, allows batch fabrication of 3D photonic crystals (PhCs), possesses the flexibility to create a variety of different lattice arrangements, and provides the freedom for arbitrary defect introduction. We describe in this paper how planar lithography is modified to achieve 3D confined exposure and multiple resist application. We demonstrated the fabrication of multilayer "woodpile" structures with and without engineered defects. We further infiltrated the resist template using a higher-index material and obtained the inverse 3D PhC structure. (C) 2005 Optical Society of America. C1 Univ Delaware, Dept Elect Engn, Newark, DE 19716 USA. Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Yao, P (reprint author), Univ Delaware, Dept Elect Engn, Newark, DE 19716 USA. EM yao@ee.udel.edu NR 12 TC 23 Z9 23 U1 1 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 4 PY 2005 VL 13 IS 7 BP 2370 EP 2376 DI 10.1364/OPEX.13.002370 PG 7 WC Optics SC Optics GA 913UX UT WOS:000228180800015 PM 19495127 ER PT J AU Burka, JA Bower, KS Cute, DL Stutzman, RD Subramanian, PS Rabin, JC AF Burka, JA Bower, KS Cute, DL Stutzman, RD Subramanian, PS Rabin, JC TI Comparison of two techniques of marking the horizontal axis during excimer laser keratorefractive surgery for myopic astigmatism SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article AB PURPOSE: To compare two methods of limbal marking used during laser refractive surgery for myopic astigmatism. DESIGN: Retrospective chart review. METHODS: Forty-two eyes of 42 patients who underwent photorefractive keratectomy (PRK) or laser-assisted in, situ keratomileusis (LASIK) for myopic astigmatism were marked preoperatively to identify the horizontal axis. In 18 eyes, marks were placed at the slit lamp (SL) with the slit beam set at 180 degrees as a reference. In 24 eyes, marks were placed in the laser room (LR) immediately before reclining under the laser. All treatments were performed with the Alcon LADARVision excimer laser system. Vector analysis of postoperative cylinder and reduction in cylinder and uncorrected and best, corrected visual acuity were evaluated for both groups. RESULTS: The mean postoperative magnitude of error was -0.19 +/- 0.44 diopters for the LR group and -0.09 +/- 0.42 diopters for the SL group (P = .439, NS). Both groups had a mean angle of error indicating an overall counterclockwise rotation of axis with an angle of error of 6.3 +/- 8.7 degrees for the LR group and 8.0 +/- 10.2 degrees for the SL group (P = .562, NS). CONCLUSIONS: We found no significant difference in outcomes with an overall trend toward undercorrection of cylinder in both groups, leaving room for improvement after refractive surgery for myopic astigmatism (c) 2005 by Elsevier Inc. All rights reserved. C1 Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. Pacific Univ, Sch Optometry, Forest Grove, OR USA. RP Bower, KS (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, Room 2F-205,6900 Georgia Ave NW, Washington, DC 20307 USA. EM kraig.bower@na.amedd.army.mil OI Subramanian, Prem/0000-0001-5824-8322 NR 5 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD APR PY 2005 VL 139 IS 4 BP 735 EP 737 DI 10.1016/j.ajo.2004.09.080 PG 3 WC Ophthalmology SC Ophthalmology GA 914IY UT WOS:000228222300033 PM 15808184 ER PT J AU Weyand, PG Bundle, MW AF Weyand, PG Bundle, MW TI Energetics of high-speed running: integrating classical theory and contemporary observations SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE anaerobic power; aerobic power; locomotion; metabolism; skeletal muscle ID ANAEROBIC ENERGY-PRODUCTION; ACCUMULATED OXYGEN DEFICIT; HIGH-INTENSITY EXERCISE; FIBER COMPOSITION; MIDDLE-DISTANCE; SKELETAL-MUSCLE; O-2 DEFICIT; PERFORMANCE; CAPACITY; METABOLISM AB We hypothesized that the anaerobic power and aerobic power outputs during all-out runs of any common duration between 10 and 150 s would be proportional to the maximum anaerobic (E(over dot)(an-max)) and aerobic powers (E(over dot)(aer-max)) available to the individual runner. Seventeen runners who differed in E(over dot)(an-max) and E(over dot)(aer-max) (5 sprinters, 5 middle-distance runners, and 7 long distance runners) were tested during treadmill running on a 4.6 degrees incline. E(over-dot)(an-max) was estimated from the fastest treadmill speed subjects could attain for eight steps. E(over-dot)(aer-max) was determined from a progressive, discontinuous, treadmill test to failure. Oxygen deficits and rates of uptake were measured to assess the respective anaerobic and aerobic power outputs during 11-16 all-out treadmill runs that elicited failure between 10 and 220 s. We found that, during all-out runs of any common duration, the relative anaerobic and aerobic powers utilized were largely the same for sprint, middle-distance, and long-distance subjects. The similar fractional utilization of the E(over dot)(an-max) and E(over-dot)(aer-max) available during high-speed running 1) provides empirical values that modify and advance classic theory, 2) allows rates of anaerobic and aerobic energy release to be quantified from individual maxima and run durations, and 3) explains why the high-speed running performances of different event specialists can be accurately predicted (R-2 = 0.97; n = 254) from two direct measurements and the same exponential time constant. C1 Rice Univ, Dept Kinesiol, Locomot Lab, Houston, TX 77005 USA. Texas Med Ctr, Ctr Human Performance, Houston, TX USA. Univ Montana, Div Biol Sci, Flight Lab, Missoula, MT 59812 USA. USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. Harvard Univ, Museum Comparat Zool, Concord Field Stn, Bedford, MA USA. RP Bundle, MW (reprint author), Rice Univ, Dept Kinesiol, Locomot Lab, 6100 Main St, Houston, TX 77005 USA. EM mbundle@rice.edu FU NIAMS NIH HHS [R01-AR-18140-20] NR 51 TC 20 Z9 20 U1 0 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD APR PY 2005 VL 288 IS 4 BP R956 EP R965 DI 10.1152/ajpregu.00628.2004 PG 10 WC Physiology SC Physiology GA 908YV UT WOS:000227827000023 PM 15576662 ER PT J AU Lee, T Jordan, NN Sanchez, JL Gaydos, JC AF Lee, T Jordan, NN Sanchez, JL Gaydos, JC TI Selected nonvaccine interventions to prevent infectious acute respiratory disease SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Review ID DAY-CARE-CENTERS; HAND SANITIZER USE; ADENOVIRUS INFECTIONS; MILITARY PERSONNEL; RISK; INFLUENZA; EPIDEMIC; SARS; AIR; DISINFECTION AB Introduction: Infectious acute respiratory disease (ARD) is a significant cause of worldwide morbidity, disproportionately affecting individuals living in crowded conditions, such as found at military training centers, school dormitories, and correctional facilities. Vaccines have been used to protect against ARD; however, these are not always available or effective. Methods: The medical literature (1963-2004) on preventive nonvaccine ARD interventions (NOVARDIs) for infectious diseases, which addressed personal measures, administrative controls, and engineering controls, was studied during 2000 to 2004. Population-based studies in community settings (non-health care) were reviewed in detail to evaluate the effectiveness of NOVARDIs. Budgetary and logistic factors as well as acceptance were considered in formulating recommendations for implementation of NOVARDIs in military training centers. Results: Thirty-eight population-based studies contained in 35 publications were examined. Three studies contained information on multiple NOVARDIs. Nine studies supported the use of personal measures relating to hand hygiene. Ten studies supported administrative controls such as cohorting military training units to reduce contact between units (4 studies), providing adequate personal space to reduce crowding (5), and cloth barriers between beds (I); and 14 studies supported the use of engineering controls such as increased indoor air dilution and ventilation (2), dust suppression (4), and air sterilization (8). Conclusions: Promoting hand hygiene and reducing crowding through the provision of adequate living space and cohorting of training units may offer benefits in respiratory disease control. These interventions, along with UV lights and air dilution/ventilation, deserve further evaluation in controlled studies to assess their efficacy. NOVARDIs could benefit military and other populations living in close contact. (Am J Prev Med 2005;28 (3):305-316) (c) 2005 American Journal of Preventive Medicine. C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. US Dept Def, Global Emerging Infect Surveillance & Response Sy, Silver Spring, MD USA. RP Lee, T (reprint author), 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Terrence.Lee@us.army.mil NR 77 TC 17 Z9 18 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD APR PY 2005 VL 28 IS 3 BP 305 EP 316 DI 10.1016/j.amepre.2004.12.010 PG 12 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 908MA UT WOS:000227789900011 PM 15766621 ER PT J AU Bui-Mansfield, LT Rohini, D Bagg, M AF Bui-Mansfield, LT Rohini, D Bagg, M TI Tenosynovial chondromatosis of the ring finger SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID HAND C1 Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. Wake Forest Univ, Sch Med, Dept Radiol, Winston Salem, NC 27157 USA. Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Surg, Orthoped Serv, Ft Sam Houston, TX 78234 USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM liem_mansfield@hotmail.com NR 3 TC 8 Z9 10 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD APR PY 2005 VL 184 IS 4 BP 1223 EP 1224 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 911VY UT WOS:000228035600030 PM 15788599 ER PT J AU Hartzell, JD Torres, D Kim, P Wortmann, G AF Hartzell, JD Torres, D Kim, P Wortmann, G TI Incidence of bacteremia after routine tooth brushing SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE endocarditis; prevention; bacteremia; teeth ID AMERICAN-HEART-ASSOCIATION; INFECTIVE ENDOCARDITIS; ANTIBIOTIC-PROPHYLAXIS; PREVENTION; RECOMMENDATIONS; DENTISTRY; EFFICACY; TIME AB Background: The American Heart Association first developed recommendations on antibiotic prophylaxis against infective endocarditis during dental procedures more than 50 years ago. These recommendations were partly based on the fact that bacteremia occurs with dental procedures. Previous studies in the 1970s and earlier demonstrated that patients become bacteremic after tooth brushing. Improved culture techniques suggest that these rates could be higher now. The objective of this study was to determine the current incidence of bacteremia after routine tooth brushing. Methods: Thirty military beneficiaries were enrolled in a prospective, institutional review board-approved study after providing informed consent. The incidence of bacteremia after routine tooth brushing for 1 minute using a standardized soft-bristle toothbrush was prospectively measured in 30 healthy adults at three different time points (at baseline and 30 seconds and 20 minutes after brushing). Periodontal Screening and Recording (PSR) scores were recorded for each patient to assess periodontal disease. Results: Three of 180 blood cultures were positive for Propionibacterium acnes (a known contaminant). The remaining blood cultures were all negative. The average PSR score was 9.8 (standard deviation 3.17) for 17 of 30 subjects. Conclusions: The rate of true bacteremia in this study was zero, which is much lower than previous studies. Bacteremia after tooth brushing in a healthy population is a rare occurrence. Data from previous studies may no longer apply to the current Population. Results similar to the ones found in this study during other dental procedures could be an impetus to reevaluate infective endocarditis prophylaxis guidelines. C1 Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Oral & Maxillofacial Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Infect Dis Fellowship Program, Washington, DC 20307 USA. RP Hartzell, JD (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Joshua.hartzell@na.amedd.army.mil NR 19 TC 27 Z9 29 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-9629 J9 AM J MED SCI JI Am. J. Med. Sci. PD APR PY 2005 VL 329 IS 4 BP 178 EP 180 DI 10.1097/00000441-200504000-00003 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 916TT UT WOS:000228409800003 PM 15832100 ER PT J AU Thaisomboonsuk, BK Clayson, ET Pantuwatana, S Vaughn, DW Endy, TP AF Thaisomboonsuk, BK Clayson, ET Pantuwatana, S Vaughn, DW Endy, TP TI Characterization of dengue-2 virus binding to surfaces of mammalian and insect cells SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ENVELOPE PROTEIN; MONOCLONAL-ANTIBODIES; SIMIAN VIRUS-40; MOSQUITO CELLS; VERO CELLS; RECEPTOR; INFECTION; ENTRY; IDENTIFICATION; MACROPHAGES AB The binding of dengue type 2 (DEN-2) virus to mammalian (LLC-MK2 and Vero) and mosquito (C6/36 and AP61) cell surfaces was investigated by a virus-binding assay using purified H-3-labeled DEN-2 virus. The DEN-2 virus binding to all four cell types was specific and saturable, indicating the presence of a single class of receptors (ranging from 3.7 x 10(3) to 3.5 x 10(4) receptors/cell) with a high affinity for DEN-2 virus (K-d ranging from 98 to 171. pM). Treatment of cell surfaces with certain glycosidases significantly reduced virus binding to mammalian cell lines, but not to the insect cell lines examined. Furthermore, heparin was found to compete with mammalian cell receptors for binding to DEN-2 virus and to inhibit viral infection of mammalian cells, but heparin had no effect on viral binding to or infection of insect cells. These results confirm previous reports suggesting that DEN-2 virus receptors on mammalian cell lines are different from those on insect cell lines. C1 USA, Med Component, Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand. Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand. RP Thaisomboonsuk, BK (reprint author), USA, Med Component, Armed Forces Res Inst Med Sci, Dept Virol, APO AP 96546, Bangkok, Thailand. EM ButsayaT@afrims.org; Edward.Clayson@det.amedd.army.edu; pantuwan@bucc4.buu.ac.th; David.Vaughn@amedd.army.mil; Timothy.Endy@na.amedd.army.mil NR 38 TC 33 Z9 34 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2005 VL 72 IS 4 BP 375 EP 383 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 915KP UT WOS:000228303400005 PM 15827273 ER PT J AU Bosio, CF Harrington, LC Jones, JW Sithiprasasna, R Norris, DE Scott, TW AF Bosio, CF Harrington, LC Jones, JW Sithiprasasna, R Norris, DE Scott, TW TI Genetic structure of Aedes aegypti populations in Thailand using mitochondrial DNA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID YELLOW-FEVER MOSQUITO; MICROSATELLITE MARKERS; OVIPOSITION SITES; PUERTO-RICO; DIFFERENTIATION; DENGUE; FLOW; GENEALOGIES; CULICIDAE; DISTANCE AB A hierarchical population genetic study was conducted among 19 Aedes aegypti populations in Thailand from Chiang Mai in the north to Songkhla province in the south. Single-strand conformation polymorphism analysis was used to examine variation in a 359-basepair region of the NADH dehydrogenase subunit 4 mitochondrial DNA gene (ND4). Seven haplotypes were detected in two lineages previously identified in ND4 haplotypes from North America. Gene flow estimates and highly significant variation among populations within 25 kilometers implicated genetic drift and vector control efforts as major factors in genetic structure. Mantel regression analysis demonstrated no isolation by distance. Urban areas were relatively parmaictic, while suburban/rural sites exhibited more restricted gene flow. Significant genetic structure among groups of collections > 100 kilometers apart is consistent with recent (similar to 50 year) expansion of Ae. aegypti from highly populated areas accompanied by founder effects, but could also reflect the overall low genetic diversity in ND4 in Thailand. C1 Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. Cornell Univ, Dept Entomol, Ithaca, NY 14853 USA. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Baltimore, MD USA. RP Bosio, CF (reprint author), Dept Microbiol, 1682 Campus Delivery, Ft Collins, CO 80523 USA. EM Christopher.Bosio@colostate.edu; lch27@cornell.edu; jonesjw2@afrims.org; ratanas@afrims.org; dnorris@jfisph.edu; twscott@ucdavis.edu FU NIAID NIH HHS [AI-22119] NR 45 TC 55 Z9 56 U1 2 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2005 VL 72 IS 4 BP 434 EP 442 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 915KP UT WOS:000228303400014 PM 15827282 ER PT J AU Vinoles, J Serra, M Russi, JC Ruchansky, D Sosa-Estani, S Montano, SM Carrion, G Eyzaguirre, LM Carr, JK Olson, JG Bautista, CT Sanchez, JL Weissenbacher, M AF Vinoles, J Serra, M Russi, JC Ruchansky, D Sosa-Estani, S Montano, SM Carrion, G Eyzaguirre, LM Carr, JK Olson, JG Bautista, CT Sanchez, JL Weissenbacher, M TI Seroincidence and phylogeny of human immunodeficiency virus infections in a cohort of commercial sex workers in Montevideo, Uruguay SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID BF RECOMBINANTS; SOUTH-AMERICA; HIV TYPE-1; RISK; PREVALENCE; ARGENTINA; SUBTYPES; TRANSMISSION; PROSTITUTES; SEQUENCES AB A cohort study involving 60 human immunodeficiency virus (HIV)-negative male transvestite commercial sex workers (CSWs) was conducted in Montevideo, Uruguay in 1999-2001. Serum samples were tested for HIV by an enzyme-linked immunosorbent assay screening with immunoblot confirmation. Six participants seroconverted for an incidence-density rate of 6.03 (95% confidence interval = 2.21-13.12) per 100 person-years. Inconsistent condom use during client sex (adjusted hazard ratio [AHR] = 6.7), during oral sex (AHR = 5.6), and at the last sexual encounter (AHR = 7.8), and use of marihuana (AHR = 5.4) were marginally associated with HIV seroconversion. Five samples were genotyped in the protease and reverse transcriptase regions; three were subtypes B and two were BF recombinants. Full genome analysis of four samples confirmed all three subtype B samples and one of the two BF recombinants. Male transvestite CSWs sustained a high rate of HIV infection. Larger prospective studies are required to better define subtypes and associated sexual and drug-related risk factors. C1 Walter Reed Army Med Ctr, US Mil HIV Res Program, Rockville, MD 20850 USA. Minist Hlth, Dept Labs Publ Hlth, Montevideo 11200, Uruguay. Minist Hlth, Dept Labs Publ Hlth, Montevideo 11200, Uruguay. Henry M Jackson Fdn, Rockville, MD 20850 USA. Univ Buenos Aires, Sch Med, Dept Microbiol, RA-1121 Buenos Aires, DF, Argentina. USN, Med Res Ctr Detachment, Lima, Peru. RP Vinoles, J (reprint author), Walter Reed Army Med Ctr, US Mil HIV Res Program, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. RI Bautista, Christian/B-2812-2011 NR 28 TC 13 Z9 13 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 2005 VL 72 IS 4 BP 495 EP 500 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 915KP UT WOS:000228303400026 PM 15827294 ER PT J AU Sun, WB Loeb, NG Tanev, S Videen, G AF Sun, WB Loeb, NG Tanev, S Videen, G TI Finite-difference time-domain solution of light scattering by an infinite dielectric column immersed in an absorbing medium SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT Biomedical Topical Meeting CY APR, 2004 CL Miami Beach, FL SP Opt Soc Amer ID PERFECTLY MATCHED LAYER; MIE-SCATTERING; SPHERICAL-PARTICLES; MAXWELLS EQUATIONS; NUMERICAL-SOLUTION; EXTINCTION; SPHERES AB The two-dimensional (2-D) finite-difference time-domain (FDTD) method is applied to calculate light scattering and absorption by an arbitrarily shaped infinite column embedded in an absorbing dielectric medium. A uniaxial perfectly matched layer (UPML) absorbing boundary condition is used to truncate the computational domain. The single-scattering properties of the infinite column embedded in the absorbing medium, including scattering phase functions and extinction and absorption efficiencies, are derived by use of an area integration of the internal field. An exact solution for light scattering and absorption by a circular cylinder in an absorbing medium is used to examine the accuracy of the 2-D UPML FDTD code. With use of a cell size of 1/120 incident wavelength in the FDTD calculations, the errors in the extinction and absorption efficiencies and asymmetry factors from the 2-D UPML FDTD are generally smaller than similar to 0.1%. The errors in the scattering phase functions are typically smaller than similar to 4%. With the 2-D UPML FDTD technique, light scattering and absorption by long noncircular columns embedded in absorbing media can be accurately solved. (c) 2005 Optical Society of America. C1 Hampton Univ, Ctr Atmospher Sci, Hampton, VA 23668 USA. NASA, Langley Res Ctr, Hampton, VA 23681 USA. Vitesse Reskilling Canada, Ottawa, ON K1A 0R6, Canada. USA, Res Lab, Adelphi, MD 20783 USA. RP Hampton Univ, Ctr Atmospher Sci, Hampton, VA 23668 USA. EM w.sun@larc.nasa.gov NR 25 TC 10 Z9 10 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD APR 1 PY 2005 VL 44 IS 10 BP 1977 EP 1983 DI 10.1364/AO.44.001977 PG 7 WC Optics SC Optics GA 911WG UT WOS:000228036600025 PM 15813534 ER PT J AU Kuncicky, DM Christesen, SD Velev, OD AF Kuncicky, DM Christesen, SD Velev, OD TI Role of the micro- and nanostructure in the performance of surface-enhanced Raman scattering substrates assembled from gold nanoparticles SO APPLIED SPECTROSCOPY LA English DT Article DE surface-enhanced Raman spectroscopy; colloidal crystal templating; structured gold films; cyanide detection; nanoparticles ID SILVER-ISLAND FILMS; MELTING TEMPERATURE; COLLOID MONOLAYERS; NANOSPHERE LITHOGRAPHY; METALLIC CLUSTERS; POROUS MATERIALS; SPECTROSCOPY; PARTICLES; RESONANCE; AG AB Highly active and stable substrates for surface-enhanced Raman scattering (SERS) can be fabricated by using colloidal crystals to template gold nanoparticles into structured porous films. The structure-dependent performance of these SERS substrates was systematically characterized with cyanide in continuous flow microfluidic chambers. A matrix of experiments was designed to isolate the SERS contributions arising from nano- and microscale porosity, long-range ordering of the micropores, and the thickness of the nanoparticle layer. The SERS results were compared to the substrate structure observed by scanning electron microscopy (SEM) and optical microscopy to correlate substrate structure to SERS performance. The Raman peak intensity was consistently highest for nanoporous substrates with three-dimensionally ordered micropores, and decreases if the micropores are not ordered or not templated. Removing the nanoseale porosity by fusion of the nanoparticles (without removing the large micropores) leads to a drastic plunge in substrate performance. The peak intensity does not strongly correlate to the thickness of the nanoparticle films. The results make possible the efficient controlled fabrication of stable, reproducible, and highly active substrates for SERS based chemical sensors with continuous sampling. C1 N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. USA, RDECOM, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM odvelev@unity.ncsu.edu RI Velev, Orlin/A-2853-2008 NR 44 TC 43 Z9 43 U1 4 U2 37 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-7028 EI 1943-3530 J9 APPL SPECTROSC JI Appl. Spectrosc. PD APR PY 2005 VL 59 IS 4 BP 401 EP 409 PG 9 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 914NP UT WOS:000228234900002 PM 15901324 ER PT J AU Kaplan, KJ AF Kaplan, KJ TI Nebulous corpora amylacea SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. RP Kaplan, KJ (reprint author), Walter Reed Army Med Ctr, Dept Pathol, 6900 Georgia Ave NW,Ward 47,Off 4705, Washington, DC 20307 USA. EM keith.kaplan@na.amedd.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD APR PY 2005 VL 129 IS 4 BP 543 EP 543 PG 1 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA 912NJ UT WOS:000228085400023 PM 15794686 ER PT J AU Callahan, CW Malone, F Estroff, D Person, DA AF Callahan, CW Malone, F Estroff, D Person, DA TI Effectiveness of an internet-based store-and-forward telemedicine system for pediatric subspecialty consultation SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE LA English DT Article ID INTRAOBSERVER DIAGNOSTIC CORRELATION; HEALTH-CARE NEEDS; TELEDERMATOLOGY; CHILDREN; PACIFIC AB Background: Pediatric subspecialists are often separated from the children who need them by distance, time, Or socioeconomic factors. The Electronic Children's Hospital of the Pacific is an Internet-based store-and-forward pediatric consultation system established to overcome these barriers. Objective: To characterize the use of the Electronic Children's Hospital of the Pacific and its impact on access to specialty care, the quality of the care provided, and cost savings. Design: Prospective trial Setting: Twenty-two military treatment facilities in the Pacific. Participants: Primary care providers, pediatric consultants, and 5 reviewers. Main Outcome Measures: Consult response time, physician panel review, and evacuation cost avoidance. Results: There were 267 cases from 16 sites. The mean +/- SD response time by a consultant was 32 8 hours. The panel review deemed that the initial diagnosis was changed or modified in 15% (39/267) of the cases, the diagnostic plan. was changed or modified in 21% (57/267), and the treatment plan was changed or modified in 24% (64/267) (P <.01 for all). Routine air evacuations to,a tertiary care medical center were avoided in 32 cases (12%), with an estimated cost savings of, $185408. Conclusions: The Electronic Children's Hospital of the Pacific improved the quality of patient care by providing expeditious specialty consultation. Significant cost avoidance in this military pediatric population was documented. Store-and-forward Internet-based teleconsultation is an effective means of providing pediatric subspecialty consultation to a population of underserved children. C1 Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Callahan, CW (reprint author), Tripler Army Med Ctr, Dept Pediat, MCHK PE,1 Jarrett White Rd, Honolulu, HI 96859 USA. EM charles.callahan@us.army.mil NR 14 TC 24 Z9 24 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 1072-4710 J9 ARCH PEDIAT ADOL MED JI Arch. Pediatr. Adolesc. Med. PD APR PY 2005 VL 159 IS 4 BP 389 EP 393 DI 10.1001/archpedi.159.4.389 PG 5 WC Pediatrics SC Pediatrics GA 912WU UT WOS:000228111400019 PM 15809396 ER PT J AU Wainner, RS Fritz, JM Irrgang, JJ Delitto, A Allison, S Boninger, ML AF Wainner, RS Fritz, JM Irrgang, JJ Delitto, A Allison, S Boninger, ML TI Development of a clinical prediction rule for the diagnosis of carpal tunnel syndrome SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article; Proceedings Paper CT Meeting of the American-Physical-Therapy-Association CY FEB 13-18, 2001 CL SAN ANTONIO, TX SP Amer Phys Therapy Assoc DE carpal tunnel syndrome; physical examination; projections and predictions; rehabilitation ID BODY-MASS INDEX; PHYSICAL-EXAMINATION; MEDICAL LITERATURE; LIKELIHOOD RATIOS; USERS GUIDES; PROSPECTIVE VALIDATION; PRACTICE PARAMETER; NERVE-CONDUCTION; DECISION RULES; MEDIAN NERVE AB Objectives: To develop a clinical prediction rule (CPR) and to assess the reliability and diagnostic accuracy of individual clinical examination items for the diagnosis of carpal tunnel syndrome (CTS). Design: Prospective diagnostic test study with blind comparison to a reference criterion of a compatible clinical presentation and abnormal electrophysiologic findings. Setting: Multicenter medical center and community hospital with patient referrals from ambulatory primary care and specialty practice settings. Participants: Eight-two consecutively referred patients (50% men; mean age. 45 +/- 12y) with Suspected cervical radiculopathy or CTS referred for electrophysiologic examination. Interventions: Not applicable. Main Outcome Measures: Sensitivity, specificity, and likelihood ratios. Results: The CPR identified in this study consisted of 1 question (shaking hands for symptom relief), wrist-ratio index greater than .67, Symptom Severity Scale score greater than 1.9, reduced median sensory field of digit I, and age greater than 45 years. The likelihood ratio for the CPR was 18.3 when all 5 tests were positive. Interrater reliability was acceptable for all but 2 clinical examination items. Conclusions: The CPR identified was more useful for the diagnosis of CTS than any sin-le test item and resulted in posttest probability changes of up to 56%. Further investigation is required both to validate the test-item cluster and to improve point-estimate precision. C1 USA, Baylor Grad Program Phys Therapy, Ft Sam Houston, TX 78234 USA. Univ Utah, Salt Lake City, UT USA. Univ Pittsburgh, Dept Phys Therapy, Pittsburgh, PA USA. Rocky Mt Univ Hlth Profess, Provo, UT USA. Univ Pittsburgh, Med Ctr, Dept Phys Med & Rehabil, Pittsburgh, PA USA. RP Wainner, RS (reprint author), 3151 Scott Rd,Ste 1303, Ft Sam Houston, TX 78234 USA. EM robert.wainner@cen.amedd.army.mil OI Boninger, Michael/0000-0001-6966-919X NR 69 TC 46 Z9 49 U1 2 U2 6 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD APR PY 2005 VL 86 IS 4 BP 609 EP 618 DI 10.1016/j.apmr.2004.11.008 PG 10 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 914ON UT WOS:000228237300001 PM 15827908 ER PT J AU Convertino, VA Cooke, WH Lurie, KG AF Convertino, VA Cooke, WH Lurie, KG TI Inspiratory resistance as a potential treatment for orthostatic intolerance and hemorrhagic shock SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE arterial pressure regulation; autonomic function; baroreflex; cardiac arrest; heat stroke; orthostatic hypotension ID BODY NEGATIVE-PRESSURE; IMPEDANCE THRESHOLD; CARDIOPULMONARY-RESUSCITATION; PULSATILE PRESSURE; SPACEFLIGHT; RESPONSES; EXERCISE; HUMANS; VOLUME; HEART AB Loss of consciousness due to central hypovolemia can occur clue to sudden cardiovascular decompensation in normal individuals or hypovolemic shock in Wounded patients. A variety of devices have been developed to sustain perfusion to the brain including anti-G suits worn by pilots and returning astronauts and applied to patients as "shock trousers." However, all countermeasures developed to date suffer from problems that limit their utility in the field. An "impedance threshold device" (ITD) has recently been developed that acutely increases central blood volume by forcing the thoracic muscles to develop increased negative pressure, thus drawing venous blood from extrathoracic cavities into the heart and lungs. We review here a series of experiments that demonstrate the application of the ITD to a variety of experimental conditions, including its use to: 1) increase heart rate, stroke volume, and arterial BP in normovolemia and hypovolemia; 2) increase cerebral blood flow velocity; 3) reset cardiac baroreflex function to a higher operating range for BP; 4) lower intracranial pressure; and 5) reduce orthostatic symptoms. In this brief review, we present evidence which supports further consideration of using inspiratory resistance as a countermeasure against circulatory collapse associated with orthostatic instability and hemorrhagic shock. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Minnesota, Minneapolis, MN USA. Adv Circulatory Syst Inc, Minneapolis, MN USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil NR 47 TC 29 Z9 30 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 2005 VL 76 IS 4 BP 319 EP 325 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 912VT UT WOS:000228108700001 PM 15828629 ER PT J AU Dwarakanath, S Bruno, JG Shastry, A Phillips, T John, AA Kumar, A Stephenson, LD AF Dwarakanath, S Bruno, JG Shastry, A Phillips, T John, AA Kumar, A Stephenson, LD TI Quantum dot-antibody and aptamer conjugates shift fluorescence upon binding bacteria (vol 325, pg 739, 2004) SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Correction C1 Nanosci Diagnost Inc, Austin, TX 78726 USA. Operat Technol Corp, San Antonio, TX 78229 USA. USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Dwarakanath, S (reprint author), Nanosci Diagnost Inc, 10520 Canyon Vista Way, Austin, TX 78726 USA. EM su@nanosciencediagnostics.com NR 1 TC 1 Z9 1 U1 1 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD APR 1 PY 2005 VL 329 IS 1 BP 416 EP 416 DI 10.1016/j.bbrc.2005.02.001 PG 1 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 903HE UT WOS:000227415700059 ER PT J AU Haynes, RK Chan, HW Ho, WY Ko, CKF Gerena, L Kyle, DE Peters, W Robinson, BL AF Haynes, RK Chan, HW Ho, WY Ko, CKF Gerena, L Kyle, DE Peters, W Robinson, BL TI Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate SO CHEMBIOCHEM LA English DT Review DE antimalarial; artemisinin; glycosylamine; phase-transfer catalysis; synthesis ID QINGHAO ARTEMISINIC ACID; SOLUBLE DIHYDROARTEMISININ DERIVATIVES; SUBSEQUENT CONVERSION; BIOLOGICAL-ACTIVITY; CONJUGATE ADDITION; PLASMODIUM-FALCIPARUM; MEDICINAL CHEMISTRY; HEPATIC-METABOLISM; TRICYCLIC ANALOGS; AGENT ARTEMISININ AB An economical phase-transfer method is used to prepare 10-arylaminoartemisinins from DHA and arylamines, and artemether, arteether, and artelinate from the corresponding alcohols. In vivo sc screens against Plasmodium berghei and R yoelii in mice reveal that the p-fluorophenylamino derivative 5g is some 13 and 70 times, respectively, more active than artesunate; this reflects the very high sc activity of 10-alkylaminoartemisinins. However, through the po route, the compounds are less active than the alkylaminoartemisinins, but still approximately equipotent with artesunate. C1 Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Northwick Pk Inst Med Res, Ctr Trop Antiprotozoal Chemotherapy, Harrow HA1 3UJ, Middx, England. RP Haynes, RK (reprint author), Hong Kong Univ Sci & Technol, Dept Chem, Clear Water Bay, Kowloon, Hong Kong, Peoples R China. EM haynes@ust.hk NR 102 TC 18 Z9 18 U1 0 U2 8 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1439-4227 J9 CHEMBIOCHEM JI Chembiochem PD APR PY 2005 VL 6 IS 4 BP 659 EP 667 DI 10.1002/cbic.200400366 PG 9 WC Biochemistry & Molecular Biology; Chemistry, Medicinal SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 916VD UT WOS:000228413500013 PM 15812783 ER PT J AU Harmon, SM King, JK Gladden, JB Chandler, GT Newman, LA AF Harmon, SM King, JK Gladden, JB Chandler, GT Newman, LA TI Mercury body burdens in Gambusia holbrooki and Erimyzon sucetta in a wetland mesocosm amended with sulfate SO CHEMOSPHERE LA English DT Article DE mercury; methylmercury; Gambusia holbrooki; Erimyzon sucetta; sulfate ID DESULFOVIBRIO-DESULFURICANS LS; ATOMIC FLUORESCENCE DETECTION; NORTHERN FLORIDA EVERGLADES; AQUEOUS-PHASE ETHYLATION; METHYL MERCURY; GAS-CHROMATOGRAPHY; ESTUARINE SEDIMENT; METHYLMERCURY; FISH; ECOSYSTEMS AB This study used an experimental model of a constructed wetland to evaluate the risk of mercury methylation when the soil is amended with sulfate. The model was planted with Schoenoplectus californicus and designed to reduce copper, mercury, and metal-related toxicity in a wastestream. The sediments of the model were varied during construction to provide a control and two levels of sulfate treatment, thus allowing characterization of sulfate's effect on mercury methylation and bioaccumulation in periphyton and two species of fish-eastern mosquitofish (Gambusia holbrooki) and lake chubsucker (Erimyzon sucetta). After one year in the experimental model, mean dry-weight normalized total mercury concentrations in mosquitofish from the non-sulfate treated controls (374 +/- 77 ng/g) and the reference location (233 +/- 17 ng/g) were significantly lower than those from the low and high sulfate treatments (520 +/- 73 and 613 +/- 80 ng/g, respectively). For lake chubsucker, mean total mercury concentration in fish from the high sulfate treatment (276 +/- 63 ng/g) was significantly elevated over that observed in the control (109 +/- 47 ng/g), the low sulfate treatment (122 +/- 42 ng/g), and the reference population (41 +/- 2 ng/g). Mercury in periphyton was mostly inorganic as methylmercury ranged from 6.6 ng/g (dry weight) in the control to 9.8 ng/g in the high sulfate treatment, while total mercury concentrations ranged from 1147 ng/g in the control to a high of 1297 ng/g in the low sulfate treatment. Fish methylmercury bioaccumulation factors from sediment ranged from 52 to 390 and from 495 to 3059 for water. These results suggest that sulfate treatments add a factor of risk due to elevated production of methylmercury in sediment and porewater which biomagnified into small fish, and may potentially increase through the food web. (c) 2005 Elsevier Ltd. All rights reserved. C1 Univ S Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA. USA Corps Engineers, Savannah, GA 31402 USA. Westinghouse Savannah River Co, Aiken, SC 29808 USA. Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29808 USA. RP Newman, LA (reprint author), Univ S Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA. EM lnewman@sph.sc.edu NR 50 TC 6 Z9 7 U1 2 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD APR PY 2005 VL 59 IS 2 BP 227 EP 233 DI 10.1016/j.chemosphere.2004.11.088 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 908WZ UT WOS:000227822200009 PM 15722094 ER PT J AU Jezior, MR Kent, SM Atwood, JE AF Jezior, MR Kent, SM Atwood, JE TI Exercise testing in Wolff-Parkinson-White syndrome - Case report with ECG and literature review SO CHEST LA English DT Article DE exercise test; preexcitation syndromes; Wolff-Parkinson-White syndrome ID SUDDEN-DEATH; RISK; CONDUCTION AB ECG changes during exercise stress testing, such as false-positive ST-segment depression and disappearance of the delta wave, are reported in patients with the Wolff-Parkinson-White (WPW) pattern. We present a case of exercise testing in a 53-year-old man with WPW syndrome with ischemic-appearing ECG changes and normal nuclear stress perfusion study findings who was thought to be at clinically low risk for having significant coronary disease. A literature review is discussed. Although ST-segment depression typical for ischemia occurs in half of the patients in whom WPW syndrome is reported, exercise testing is still an important tool in their evaluation. Data other than ECG response can be interpreted in the context of clinical history and physical examination findings to stratify the risk of coronary disease. Complete and sudden disappearance of the delta wave has been seen during exercise in 20% of patients with WPW syndrome and can identify those who are at low risk for sudden arrhythmic death. C1 Walter Reed Army Med Ctr, USA, Med Corps, Serv Cardiol, Washington, DC 20307 USA. RP Jezior, MR (reprint author), Walter Reed Army Med Ctr, USA, Med Corps, Serv Cardiol, Washington, DC 20307 USA. EM matthew.jezior@na.amedd.army.mil NR 19 TC 20 Z9 22 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD APR PY 2005 VL 127 IS 4 BP 1454 EP 1457 DI 10.1378/chest.127.4.1454 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 915ZG UT WOS:000228349900060 PM 15821231 ER PT J AU Kuklo, TR Lehman, RA Gajewski, DA Schaefer, RA AF Kuklo, TR Lehman, RA Gajewski, DA Schaefer, RA TI Enlarging knee mass in a 13-year-old girl SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID SOFT-TISSUE; MYXOID LIPOSARCOMA; LIPOMA; TUMORS C1 Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Washington, DC USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Kuklo, TR (reprint author), 15619 Thistlebridge Rd, Rockville, MD 20853 USA. EM teresa.schroeder@na.amedd.army.mil NR 14 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD APR PY 2005 IS 433 BP 271 EP 276 DI 10.1097/01.blo.0000160002.63049.5d PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 913RF UT WOS:000228170000041 PM 15805968 ER PT J AU Young, RSK Eccles, TG Giangiulio, L Taylor, CE AF Young, RSK Eccles, TG Giangiulio, L Taylor, CE TI Army pediatricians in Iraq SO CLINICAL PEDIATRICS LA English DT Editorial Material C1 Hosp St Raphael, Dept Pediat, New Haven, CT 06511 USA. USA, CT Natl Guard, Area Support Med Battal, Med Corps, New Haven, CT USA. Yale Univ, Sch Med, New Haven, CT USA. Mil Intelligence Battal 1st, HHSC, Med Corps, MAJ, APO, AE 09096 USA. USA, Keller Community Hosp, Med Corps, CPT, W Point, NY USA. RP Young, RSK (reprint author), Hosp St Raphael, Dept Pediat, 1450 Chapel St, New Haven, CT 06511 USA. NR 12 TC 0 Z9 0 U1 0 U2 1 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD APR PY 2005 VL 44 IS 3 BP 189 EP 192 DI 10.1177/000992280504400301 PG 4 WC Pediatrics SC Pediatrics GA 919CH UT WOS:000228595400001 PM 15821842 ER PT J AU Shields, CH Styadi-Park, G McCown, MY Creamer, KM AF Shields, CH Styadi-Park, G McCown, MY Creamer, KM TI Clinical utility of the bispectral index score when compared to the university of Michigan sedation scale in assessing the depth of outpatient pediatric sedation SO CLINICAL PEDIATRICS LA English DT Article ID NON-ANESTHESIOLOGISTS; PROCEDURAL SEDATION; PRACTICE GUIDELINES; DEEP SEDATION; CHILDREN; SEVOFLURANE; ANALGESIA; MONITOR; RELIABILITY; MIDAZOLAM AB This single blinded observational study compared the bispectral index (BIS) monitor with a validated pediatric sedation scale, the University of Michigan Sedation Scale (UMSS), to evaluate whether the BIS score can be used to judge the depth of sedation in pediatric outpatients. Thirty-eight children, with a mean age of 5.8 years, undergoing routine sedation for both noninvasive and gastrointestinal procedures, had simultaneous BIS and UMSS scores recorded. Sedation categories were defined as light, moderate, and deep for both UMSS and BIS. There was a moderate correlation between BIS and the UMSS, Spearman's r < -0.499. The correlation was poor for children receiving chloral hydrate, r < -0.213. The BIS score was not predictive of any specific UMSS score. The UMSS and BIS categories of sedation matched only 36% of the time. BIS underestimated the clinical level of sedation. C1 Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. RP Shields, CH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 29 TC 12 Z9 16 U1 0 U2 0 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD APR PY 2005 VL 44 IS 3 BP 229 EP 236 DI 10.1177/000992280504400306 PG 8 WC Pediatrics SC Pediatrics GA 919CH UT WOS:000228595400006 PM 15821847 ER PT J AU Buxton, TB Travis, MT O'Shea, KJ McPherson, JC Harvey, SB Plowman, KM Walsh, DS AF Buxton, TB Travis, MT O'Shea, KJ McPherson, JC Harvey, SB Plowman, KM Walsh, DS TI Low-dose infectivity of Staphylococcus aureus (SMH strain) in traumatized rat tibiae provides a model for studying early events in contaminated bone injuries SO COMPARATIVE MEDICINE LA English DT Article ID EXPERIMENTAL CHRONIC OSTEOMYELITIS; IMPLANT-RELATED OSTEOMYELITIS; OPEN FRACTURES; COLLAGEN; BINDING; LAVAGE AB Animal models of post-traumatic acute osteomyelitis (OM) that closely mimic human scenarios, including infection prophylactic procedures such as debridement and lavage, may provide a better understanding of OM. We contaminated mechanically traumatized rat tibiae (n = 69) with various doses of a Staphylococcus aureus strain (SMH) known to cause human OM and then performed curettage and lavage. Tibiae were harvested 24 h after lavage for assessment of bacterial load and determination of minimal infective doses for 50% (ID50) and 95% (ID95) of rats. Some experiments varied tibial harvest time after lavage (n = 10); for progressive infection, tibiae were evaluated at 7 and 15 days after contamination (n = 17 for each time point). At 24 h after contamination, the ID50 was 1.8 x 10(3) CFU, and the ID95 was 9.2 x 10(3) CFU. Tibial bacterial loads did not increase with inocula greater than the ID95 Lavage removed many bacteria from bone, but it did not prevent subsequent infection or disease. At 15 days after contamination, most tibiae (14 of 17) were infected, with macroscopic and radiological signs of established OM. This newly described rat OM model, with a low ID95 despite prophylactic curettage and lavage, closely mimics events in contaminated human bone injuries. This situation will allow study of early factors in contaminated bone injuries, including clinical interventions that may reduce infection and prevent disease. C1 Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. Dwight D Eisenhower Army Med Ctr, Dept Orthoped Surg, Ft Gordon, GA 30905 USA. Dwight D Eisenhower Army Med Ctr, Dept Med, Ft Gordon, GA 30905 USA. RP Walsh, DS (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. NR 28 TC 10 Z9 10 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD APR PY 2005 VL 55 IS 2 BP 123 EP 128 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 947GF UT WOS:000230630700002 PM 15884772 ER PT J AU Haskins, S Pascoe, PJ Ilkiw, JE Fudge, J Hopper, K Aldrich, J AF Haskins, S Pascoe, PJ Ilkiw, JE Fudge, J Hopper, K Aldrich, J TI Reference cardiopulmonary values in normal dogs SO COMPARATIVE MEDICINE LA English DT Article ID PATHOLOGICAL SUPPLY DEPENDENCE; BODY OXYGEN-CONSUMPTION; ARTERIAL BLOOD-GASES; ACID-BASE STATUS; ANESTHETIZED DOGS; HYPOVOLEMIC DOGS; UNANESTHETIZED DOGS; CONSCIOUS DOGS; ENERGY-EXPENDITURE; O-2 UPTAKE AB The purpose of this project was to collate canine cardiopulmonary measurements from published and unpublished studies in our laboratory in 97 instrumented, unsedated, normovolemic dogs. Body weight; arterial and mixed-venous pH and blood gases; mean arterial, pulmonary arterial, pulmonary artery occlusion, and central venous blood pressures; cardiac output; heart rate; hemoglobin; and core temperature were measured. Body surface area; bicarbonate concentration; base deficit; cardiac index; stroke volume index, systemic and pulmonary vascular resistance indices; left and right cardiac work indices; alveolar partial pressure of oxygen (pO(2)); alveolar-arterial pO(2) gradient (A-a pO(2)); arterial, mixed-venous, and pulmonary capillary oxygen content; oxygen delivery; oxygen consumption; oxygen extraction; venous admixture; arterial and mixed-venous blood CO2 contents; and CO2 production were calculated. In the 97 normal, resting dogs, mean arterial and mixed-venous pH were 7.38 and 7.36, respectively; partial pressure of carbon dioxide (pCO(2)), 40.2 and 44.1 mm Hg, respectively; base-deficit, -2.1 and -1.9 mEq/liter, respectively; pO(2,) 99.5 and 49.3 mm Hg, respectively; oxygen content, 17.8 and 14.2 ml/dI, respectively; A-a pO(2) was 6.3 mm Hg; and venous admixture was 3.6%. The mean arterial blood pressure (ABPm), mean pulmonary arterial blood pressure (PAPm), pulmonary artery occlusion pressure (PAOP) were 103, 14, and 5.5 mm Hg, respectively; heart rate was 87 beats/min; cardiac index (CI) was 4.42 liters/min/m(2); systemic and pulmonary vascular resistances were 1931 and 194 dynes(.)sec(.)cm(.5), respectively; oxygen delivery, consumption and extraction were 790 and 164 ml/min/m(2) and 20.5%, respectively. This study represents a collation of cardiopulmonary values obtained from a large number of dogs (97) from a single laboratory using the same measurement techniques. C1 Univ Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, Davis, CA 95616 USA. USA, Inst Surg Res, Div Res, Vet Support Branch, Ft Sam Houston, TX 78234 USA. Univ Calif Davis, Vet Teaching Hosp, Sch Vet Med, Davis, CA 95616 USA. RP Haskins, S (reprint author), Univ Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, Davis, CA 95616 USA. NR 56 TC 63 Z9 64 U1 1 U2 11 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD APR PY 2005 VL 55 IS 2 BP 156 EP 161 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 947GF UT WOS:000230630700008 PM 15884778 ER PT J AU Rishniw, M Schiavetta, AM Johnson, TO Erb, HN AF Rishniw, M Schiavetta, AM Johnson, TO Erb, HN TI Cardiomyopathy in captive owl monkeys (Aotus nancymae) SO COMPARATIVE MEDICINE LA English DT Article ID HEART-DISEASE; VALUES AB Dilated cardiomyopathy (DCM) was identified histopathologically in a colony of owl monkeys (Aotus nancymae) over a 15-year period. We characterized the incidence of cardiac disease echocardiographically in the colony over a 14-month period. Of 77 monkeys, 21 had systolic myocardial failure, and postmortem examination confirmed the antemortem diagnosis of DCM in eight animals. Monkeys with a questionable diagnosis at the first examination demonstrated progression of disease with time. Left ventricular end-systolic cross-sectional area and left ventricular fractional area change were the indices that most reliably discriminated between normal and diseased animals. Serum cardiac troponin I concentrations were below detectable limits in normal and diseased monkeys. The apparent high prevalence of disease in this colony precluded establishment of reference intervals for Aotus nancymae. Our study provides the first comprehensive echocardiographic evaluation of owl monkeys with cardiomyopathy. C1 Cornell Univ, Coll Vet Med, Dept Biomed Sci, Ithaca, NY 14853 USA. Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD 20910 USA. USN, Med Res Ctr, Dept Pathol, Silver Spring, MD 20910 USA. Cornell Univ, Coll Vet Med, Dept Epidemiol & Diagnost Sci, Ithaca, NY 14853 USA. RP Rishniw, M (reprint author), Cornell Univ, Coll Vet Med, Dept Biomed Sci, Ithaca, NY 14853 USA. NR 12 TC 7 Z9 7 U1 0 U2 2 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD APR PY 2005 VL 55 IS 2 BP 162 EP 168 PG 7 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 947GF UT WOS:000230630700009 PM 15884779 ER PT J AU Pelham, BW Carvallo, A Jones, JT AF Pelham, BW Carvallo, A Jones, JT TI Implicit egotism SO CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE LA English DT Article DE implicit; egotism; self-esteem ID EXPLICIT SELF-ESTEEM; SOCIAL COGNITION AB People gravitate toward people, places, and things that resemble the self. We refer to this tendency as implicit egotism, and we suggest that it reflects an unconscious process that is grounded in people's favorable self-associations. We review recent archival and experimental research that supports this position, highlighting evidence that rules out alternate explanations and distinguishes implicit egotism from closely related ideas such as mere exposure. Taken together, the evidence suggests that implicit egotism is an implicit judgmental consequence of people's positive self-associations. We conclude by identifying promising areas for future research. C1 SUNY Buffalo, Dept Psychol, Buffalo, NY 14260 USA. US Mil Acad, W Point, NY 10996 USA. RP Pelham, BW (reprint author), SUNY Buffalo, Dept Psychol, Buffalo, NY 14260 USA. EM brettpel@buffalo.edu NR 17 TC 64 Z9 64 U1 3 U2 13 PU BLACKWELL PUBLISHERS PI MALDEN PA 350 MAIN STREET, STE 6, MALDEN, MA 02148 USA SN 0963-7214 J9 CURR DIR PSYCHOL SCI JI Curr. Dir. Psychol. PD APR PY 2005 VL 14 IS 2 BP 106 EP 110 DI 10.1111/j.0963-7214.2005.00344.x PG 5 WC Psychology, Multidisciplinary SC Psychology GA 939LG UT WOS:000230073600011 ER PT J AU Sjogren, MH Sjogren, R Holtzmuller, K Winston, B Butterfield, B Drake, S Watts, A Howard, R Smith, M AF Sjogren, MH Sjogren, R Holtzmuller, K Winston, B Butterfield, B Drake, S Watts, A Howard, R Smith, M TI Interferon alfacon-1 and ribavirin versus interferon alpha-2b and ribavirin in the treatment of chronic hepatitis C SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE consensus interferon; interferon alpha-2b; hepatitis C; HCV RNA; genotype 1; ribavarin; antiviral theraphy ID CONSENSUS INTERFERON; PLUS RIBAVIRIN; VIRUS-RNA; TRIAL AB Despite advances in the therapy of chronic hepatitis C, a large number of patients do not respond to current therapies. The study objective was to assess whether a combination of interferon (IFN) alfacon-1 and ribavirin improves the response rate compared with a combination of INF alpha-2b and ribavirin in chronic hepatitis C subjects. The study was designed as an open-label, prospective, randomized, controlled study; 128 subjects with chronic hepatitis C were randomized to INF alfacon-1, 15 mu g three times per week, plus ribavirin, 1 g/day, or IFN-alpha 2b, 3 million units three times per week, plus ribavirin, 1 g/day for 48 weeks. The end point of the study was a sustained viral response, defined as undetectable HCV RNA at 24 weeks post 48 weeks of treatment. Overall, 57% of subjects in the INF alfacon-1/ribavirin group achieved a sustained antiviral response, compared with 40% of subjects in the IFN-alpha 2b/ribavirin group ( P = 0.052). In the subset of subjects with a high viral load, HCV RNA was successfully eradicated in more individuals who received INF alfacon-1/ribavirin than subjects who received IFN-alpha 2b/ribavirin ( 57 versus 31%; P = 0.025). Among individuals with genotype 1 and a high viral load, the sustained antiviral response was significantly higher with INF alfacon-1/ribavirin than with IFN-alpha 2b/ribavirin ( 46 versus 14%; P = 0.019). Adverse events were similar in both treatment groups. In conclusion, this study demonstrated that the combination of INF alfacon-1 and ribavirin provides a significantly better treatment response compared with the combination of IFN-alpha 2b and ribavirin in chronic HCV subjects infected with genotype 1 and a high viral RNA load. C1 Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Kaiser Permanente Mid Atlantic, Falls Church, VA 22406 USA. RP Sjogren, MH (reprint author), Walter Reed Army Med Ctr, Dept Clin Invest, Room 4018,Bldg 6,6900 Georgia Ave NW, Washington, DC 20307 USA. EM maria.sjogren@na.amedd.army.mil OI Watts, Amber/0000-0002-8385-1091 NR 14 TC 30 Z9 32 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD APR PY 2005 VL 50 IS 4 BP 727 EP 732 DI 10.1007/s10620-005-2564-2 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 914DM UT WOS:000228205200021 PM 15844709 ER PT J AU Yershov, AL Jordan, BS Guymon, CH Dubick, MA AF Yershov, AL Jordan, BS Guymon, CH Dubick, MA TI Relationship between the inoculum dose of Streptococcus pneumoniae and pneumonia onset in a rabbit model SO EUROPEAN RESPIRATORY JOURNAL LA English DT Article DE experimental pneumonia; inoculum dose; rabbits; Streptococcus pneumoniae ID VENTILATOR-ASSOCIATED PNEUMONIA; COMMUNITY-ACQUIRED PNEUMONIA; PNEUMOCOCCAL PNEUMONIA; GOLD-STANDARD; DIAGNOSIS; POSTMORTEM; RESISTANCE; RESOLUTION; INFECTION; RATS AB It is generally assumed that the development of bacterial pneumonia becomes possible when the dose of inhaled or aspirated pathogens overwhelms the respiratory tract host defence system, but this hypothesis has not yet been tested either clinically or experimentally. This study evaluated inoculum dose in relation to onset of experimental pneumococcal pneumonia, and estimated the median effective dose resulting in pneumonia in healthy New Zealand White rabbits (mean +/- SD 4.75 +/- 0.25 kg (n=27)). Rabbits were endobronchially inoculated with increasing doses of Streptococcus pneumoniae and pneumonia onset was observed over the following 96 h. The diagnostic approach was based on the Clinical Pulmonary Infection Score, modified for use in rabbits. Inoculation of S. pneumoniae at doses of > 4.60 log(10) cfu made the development of pneumonia in rabbits more predictable (up to 90 %). Lower doses of bacteria failed to cause pneumonia in 80 % of inoculated animals. The median effective dose was estimated by means of logistical regression, probit analyses and the Reed-Muench method, and corresponded to 4.32, 4.38 and 4.67 log(10) cfu, respectively. It is speculated that development of pneumococcal pneumonia becomes more likely when the inoculum dose exceeds a threshold of antibacterial protection, making inoculum dose a risk factor for disease onset. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Yershov, AL (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM andrey.yershov@cen.amedd.army.mil RI Lee, H/E-7918-2010 NR 32 TC 9 Z9 12 U1 0 U2 1 PU EUROPEAN RESPIRATORY SOC JOURNALS LTD PI SHEFFIELD PA 146 WEST ST, STE 2.4, HUTTONS BLDG, SHEFFIELD S1 4ES, ENGLAND SN 0903-1936 J9 EUR RESPIR J JI Eur. Resp. J. PD APR PY 2005 VL 25 IS 4 BP 693 EP 700 DI 10.1183/09031936.05.00091904 PG 8 WC Respiratory System SC Respiratory System GA 914YE UT WOS:000228263200020 PM 15802345 ER PT J AU Delgado, AV McManus, AT Chambers, JP AF Delgado, AV McManus, AT Chambers, JP TI Exogenous administration of Substance P enhances wound healing in a novel skin-injury model SO EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article DE Substance P; CO2 laser; wound healing; neurite outgrowth ID NERVE GROWTH-FACTOR; GENE-RELATED PEPTIDE; NEUROKININ-1 RECEPTOR; CELL-PROLIFERATION; UP-REGULATION; EXPRESSION; REGENERATION; RATS; NEUROPEPTIDES; OUTGROWTH AB Soft tissue injury accounts for approximately 44% of all wounds in both the military and civilian populations. Following injury to soft tissue, Substance P (SP) and other neuropeptides are released by cutaneous neurons and modulate the function of immunocompetent and inflammatory cells, as well as epithelial and endothelial cells. The interaction between these components of the nervous system and multiple target cells affecting cutaneous repair is of increasing interest. In this report, we describe the effects of SP on wound repair in a novel, laser-induced, skin-wound model. Gross and histologic examination of laser-induced injury revealed that exogenously administered SP affects wound healing via neurite outgrowth, in addition to adhesion molecule and neurokinin-1 receptor involvement in vivo. All SP effects were decreased by pretreatment with Spantide II, an SP antagonist. The elucidation of SP-mediating mechanisms is crucial to firmly establishing the involvement and interaction of the peripheral nervous system and the immune system in cutaneous repair. Findings presented here suggest that SP participates in the complex network of mediators involved in cutaneous inflammation and wound healing. C1 Univ Texas, Dept Biol, San Antonio, TX 78249 USA. USA, Inst Surg Res, Combat Casualty Care Branch, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Div Res, Ft Sam Houston, TX 78234 USA. RP Chambers, JP (reprint author), Univ Texas, Dept Biol, San Antonio, TX 78249 USA. EM jchamber@utsa.edu FU NIGMS NIH HHS [GM08194] NR 51 TC 65 Z9 67 U1 3 U2 10 PU SOC EXPERIMENTAL BIOLOGY MEDICINE PI MAYWOOD PA 195 WEST SPRING VALLEY AVE, MAYWOOD, NJ 07607-1727 USA SN 1535-3702 J9 EXP BIOL MED JI Exp. Biol. Med. PD APR PY 2005 VL 230 IS 4 BP 271 EP 280 PG 10 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 912TE UT WOS:000228101900007 PM 15792949 ER PT J AU Yeung, KJA Smith, A Zhao, AP Madden, KB Elfrey, J Sullivan, C Levander, O Urban, JF Shea-Donohue, T AF Yeung, KJA Smith, A Zhao, AP Madden, KB Elfrey, J Sullivan, C Levander, O Urban, JF Shea-Donohue, T TI Impact of vitamin E or selenium deficiency on nematode-induced alterations in murine intestinal function SO EXPERIMENTAL PARASITOLOGY LA English DT Article ID EPITHELIAL-CELL FUNCTION; NIPPOSTRONGYLUS-BRASILIENSIS; PROTECTIVE IMMUNITY; COXSACKIEVIRUS B3; INFECTION; MICE; IL-4; PARASITE; STAT6; PROTEIN AB The effects of deficiencies in the antioxidant nutrients, vitamin E and selenium, on the host response to gastrointestinal nematode infection are unknown. The aim of the study was to determine the effect of antioxidant deficiencies on nematode-induced alterations in intestinal function in mice. BALB/c mice were fed control diets or diets deficient in selenium or vitamin E and the response to a secondary challenge inoculation with Heligmosomoides polygyrus was determined. Egg and worm counts were assessed to determine host resistance. Sections of jejunum were mounted in Ussing chambers to measure changes in permeability, absorption, and secretion, or suspended in organ baths to determine smooth muscle contraction. Both selenium and vitamin E deficient diets reduced resistance to helminth infection. Vitamin E, but not selenium, deficiency prevented nematode-induced decreases in glucose absorption and hyper-contractility of smooth muscle. Thus, vitamin E status is an important factor in the physiological response to intestinal nematode infection and may contribute to antioxidant-dependent protective mechanisms in the small intestine. (c) 2005 Elsevier Inc. All rights reserved. C1 Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. USDA, Agr Res Serv, Beltsville Human Nutr Res Ctr, Nutr Requirements & Funct Lab, Beltsville, MD 20705 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. RP Shea-Donohue, T (reprint author), Univ Maryland, Sch Med, Mucosal Biol Res Ctr, 20 Penn St,HSF 2,351, Baltimore, MD 21201 USA. EM tdonohue@medicine.umaryland.edu OI Urban, Joseph/0000-0002-1590-8869 FU NIAID NIH HHS [R01 AI049316, R01AI/DK49316] NR 40 TC 13 Z9 15 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD APR PY 2005 VL 109 IS 4 BP 201 EP 208 DI 10.1016/j.exppara.2004.12.015 PG 8 WC Parasitology SC Parasitology GA 909RW UT WOS:000227879400001 PM 15755417 ER PT J AU Harvey, SP Minter, JM AF Harvey, SP Minter, JM TI Ribotyping of Burkholderia mallei isolates SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY LA English DT Article DE Burkholderia mallei; ribotyping; genotyping; DNA polymorphisms; ribosomal; subspecies identification ID PSEUDOMONAS-PSEUDOMALLEI; GLANDERS; MELIOIDOSIS; SEQUENCE; MODEL AB In this study, the subspecies differentiation of 25 isolates of Burkholderia mallei was attempted based on their ribotype polymorphisms. The isolates were from human and equine infections that occurred at various times around the world. DNA samples from each isolate were digested separately with PstI and EcoRI enzymes and probed with an Escherichia coli-derived 18-mer rDNA sequence to identify diagnostic fragments. Seventeen distinct ribotypes were identified from the combined data obtained with the two restriction enzymes. The results demonstrate the general utility of ribotyping for the subspecies identification of B. mallei isolates. (c) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. Battelle Eastern Sci & Technol Ctr, Aberdeen, MD 21001 USA. RP Harvey, SP (reprint author), USA, Edgewood Chem Biol Ctr, 5138 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM steve.harvey@us.army.mil NR 20 TC 8 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0928-8244 J9 FEMS IMMUNOL MED MIC JI FEMS Immunol. Med. Microbiol. PD APR 1 PY 2005 VL 44 IS 1 BP 91 EP 97 DI 10.1016/j.femsim.2004.12.002 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 912ZV UT WOS:000228120200010 PM 15780581 ER PT J AU Cardello, AV AF Cardello, AV TI Terminology, reliability, validity, and subjectivity in the search for the "voice of the consumer" SO FOOD QUALITY AND PREFERENCE LA English DT Article C1 USA, Natick Res Dev & Engn Ctr, Supporting Sci & Technol Directorate, Natick, MA 01760 USA. RP Cardello, AV (reprint author), USA, Natick Res Dev & Engn Ctr, Supporting Sci & Technol Directorate, Natick, MA 01760 USA. EM armand.cardello@natick.army.mil NR 5 TC 8 Z9 8 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD APR PY 2005 VL 16 IS 3 BP 203 EP 205 DI 10.1016/j.foodqual.2004.08.005 PG 3 WC Food Science & Technology SC Food Science & Technology GA 889MC UT WOS:000226446100002 ER PT J AU Hecker, W AF Hecker, W TI Finding Wilfred Owen's forwarding address: Moving beyond the World War One paradigm SO FORUM FOR MODERN LANGUAGE STUDIES LA English DT Article C1 US Mil Acad, Dept English, West Point, NY 10996 USA. RP Hecker, W (reprint author), US Mil Acad, Dept English, West Point, NY 10996 USA. NR 12 TC 1 Z9 1 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0015-8518 J9 FORUM MOD LANG STUD JI Forum Mod. Lang. Stud. PD APR PY 2005 VL 41 IS 2 BP 136 EP 148 DI 10.1093/fmls/cqi007 PG 13 WC Language & Linguistics; Literature SC Linguistics; Literature GA 919MY UT WOS:000228623400002 ER PT J AU Kubli, LR Leek, MR Dreisbach, LE AF Kubli, LR Leek, MR Dreisbach, LE TI Acoustic reflexes to Schroeder-phase harmonic complexes in normal-hearing and hearing-impaired individuals SO HEARING RESEARCH LA English DT Article; Proceedings Paper CT 23rd Midwinter Research Meeting of the Association-for-Research-in-Otolaryngology CY FEB 20-24, 2000 CL ST PETERSBURG BEACH, FL SP Assoc Res Otolaryngol DE acoustic reflex; cochlear excitation; harmonic complexes; Schroeder phase ID STAPEDIUS REFLEX; INNER-EAR; DISPERSION; STIMULI; MASKING; LISTENERS; RESPONSES; SIGNALS; GROWTH; MODEL AB Harmonic complexes generated with positive or negative Schroeder-phases may result in differences in cochlear excitation, even though their long-term spectra and amplitudes are equal. As a measure of possible differences in cochlear excitation resulting from these harmonic complexes, thresholds and growth of the acoustic reflex were assessed in normal-hearing and hearing-impaired subjects. Harmonic complexes with fundamental frequencies of 50, 100, and 200 Hz were constructed with positive and negative-Schroeder phases. In normal-hearing subjects, acoustic reflex thresholds for the 50- and 100-Hz fundamental waveforms were typically lower for negative Schroeder-phase complexes than for positive Schroeder phase stimuli. At the highest fundamental frequency of 200 Hz. there were no significant threshold differences due to phase. Hearing-impaired subjects showed a similar pattern for thresholds between the two phase selections, but with smaller differences than those observed in normal-hearing subjects. At levels above reflex threshold, the magnitude of the acoustic reflex was greater for the negative-phase than the positive-phase stimuli for the lowest fundamental frequency, but no significant differences were observed at fundamental frequencies of 100 and 200 Hz. These results are consistent with generally greater cochlear excitation in response to negative than to positive Schroeder-phase stimuli when the fundamental frequency is sufficiently low. Increased excitation may reflect a synchronization of response across a wide band of frequencies in the cochlea when the rate of frequency sweep within periods of these harmonic complexes is appropriately matched to timing characteristics of the traveling wave. (c) 2004 Elsevier B.V. All rights reserved. C1 Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. RP Kubli, LR (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM lina.kubli@na.amedd.army.mil FU NIDCD NIH HHS [DC 00626] NR 26 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-5955 J9 HEARING RES JI Hear. Res. PD APR PY 2005 VL 202 IS 1-2 BP 1 EP 12 DI 10.1016/j.heares.2004.08.012 PG 12 WC Audiology & Speech-Language Pathology; Neurosciences; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Neurosciences & Neurology; Otorhinolaryngology GA 919JM UT WOS:000228614300001 PM 15811693 ER PT J AU Watson, MD Ashley, PR Guenthner, AJ Abushagur, MAG AF Watson, MD Ashley, PR Guenthner, AJ Abushagur, MAG TI Modeling of electrooptic polymer electrical characteristics in a three-layer optical waveguide modulator SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE electrooptic polymer; frequency response; Mach-Zehnder (MZ) modulator; waveguide; waveguide layer adhesion; waveguide reactance AB The electrical characteristics of electrooptic polymer waveguide modulators are often described by the bulk reactance of the individual layers. However, the resistance and capacitance between the layers can significantly alter the electrical performance of a waveguide modulator. These interface characteristics are related to the boundary charge density and are strongly affected by the adhesion of the layers in the waveguide stack. An electrical reactance model has been derived to investigate this phenomenon at low frequencies. The model shows the waveguide stack frequency response has no limiting effects below the microwave range and that a true dc response requires a stable voltage for over 1000 h. Thus, reactance of the layers is the key characteristic of optimizing the voltage across the core layer, even at very low frequencies (> 10(-6) Hz). The results of the model are compared with experimental data for two polymer systems and show quite good correlation. C1 NASA, George C Marshall Space Flight Ctr, Huntsville, AL 35812 USA. USA, Aviat & Missile Res Dev & Engn Ctr, Huntsville, AL 35749 USA. USN, Air Warfare Ctr, China Lake, CA 93555 USA. Rochester Inst Technol, Kate Gleason Coll Engn, Rochester, NY 14623 USA. RP Watson, MD (reprint author), NASA, George C Marshall Space Flight Ctr, Huntsville, AL 35812 USA. EM Michael.D.Watson@nasa.gov; P.R.Ashley@redstone.rdec.army.mil; andrew.guenthner@navy.mil; maaeen@rit.edu NR 16 TC 1 Z9 1 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD APR PY 2005 VL 41 IS 4 BP 589 EP 595 DI 10.1109/JQE.2005.843607 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 909PB UT WOS:000227870800016 ER PT J AU Hillier, CJ Ware, LA Barbosa, A Angov, E Lyon, JA Heppner, DG Lanar, DE AF Hillier, CJ Ware, LA Barbosa, A Angov, E Lyon, JA Heppner, DG Lanar, DE TI Process development and analysis of liver-stage antigen 1, a preerythrocyte-stage protein-based vaccine for Plasmodium falciparum SO INFECTION AND IMMUNITY LA English DT Article ID SEVERE MALARIA; RESPONSES; EPITOPES; CELL; INTERLEUKIN-10; IDENTIFICATION; PROTECTION; RESISTANCE; CANDIDATE; IMMUNITY AB Plasmodium falciparum liver-stage antigen 1(LSA-1) is expressed solely in infected hepatocytes and is thought to have a role in liver schizogony and merozoite release. Specific Immoral, cellular, and cytokine immune responses to LSA-1 are well documented, with epitopes identified that correlate with antibody production, proliferative T-cell responses, or cytokine induction. With the goal of developing a vaccine against this preerythrocyte-stage protein, we undertook the good manufacturing practices (GMP) manufacture of a recombinant LSA-1 construct, LSA-NRC, incorporating the N- and C-terminal regions of the protein and two of the centrally placed 17-amino-acid repeats. To improve the protein yield, a method of codon harmonization was employed to reengineer the gene sequence for expression in Escherichia coli. A 300-liter GMP fermentation produced 8 kg of bacterial cell paste, and a three-step column chromatographic method yielded 8 mg of purified antigen per g of paste. The final bulk protein was > 98% pure, demonstrated long-term stability, and contained < 0.005 endotoxin units per 50 jig of protein. To accomplish the initial stages of evaluation of this protein as a human-use vaccine against malaria, we immunized rabbits and mice with LSA-NRC in Montanide ISA 720. New Zealand White rabbits and A/J (H-2(K)) mice produced high-titer antibodies that recognized liver-stage parasites in infected cultured human hepatocytes. Gamma interferon-producing cells, which have been associated with LSA-1-mediated protection, were detected in splenocytes harvested from immunized mice. Finally, sera taken from people living in a region where malaria is holoendemic recognized LSA-NRC by Western blotting. C1 Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. RP Lanar, DE (reprint author), Walter Reed Army Inst Res, Dept Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM david.lanar@na.amedd.army.mil RI Lanar, David/B-3560-2011; OI Barbosa, Arnoldo/0000-0001-8652-7396 NR 22 TC 45 Z9 46 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2005 VL 73 IS 4 BP 2109 EP 2115 DI 10.1128/IAI.73.4.2109-2115.2005 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 911BB UT WOS:000227975000023 PM 15784552 ER PT J AU Dutta, S Haynes, JD Barbosa, A Ware, LA Snavely, JD Moch, JK Thomas, AW Lanar, DE AF Dutta, S Haynes, JD Barbosa, A Ware, LA Snavely, JD Moch, JK Thomas, AW Lanar, DE TI Mode of action of invasion-inhibitory antibodies directed against apical membrane antigen 1 of Plasmodium falciparum SO INFECTION AND IMMUNITY LA English DT Article ID ERYTHROCYTE INVASION; VACCINE CANDIDATE; MALARIA; MEROZOITES; SURFACE; PROTEIN; LOCALIZATION; EXPRESSION; ECTODOMAIN; PARASITES AB Antibodies against apical membrane antigen 1 (AMA-1) of Plasmodiumfalciparum inhibit merozoite invasion into erythrocytes. Invasion-inhibitory polyclonal AMA-1 antibodies inhibit secondary proteolytic processing and surface redistribution of AMA-1 on merozoites. We present evidence supporting inhibition of processing and redistribution as probable causes of inhibition of invasion by polyclonal antibodies. Polyclonal anti-AMA-1 was much more inhibitory than monoclonal antibody (MAb) 4G2dc1 in an invasion assay. Although both polyclonal and monoclonal immunoglobulin G (IgG) inhibited secondary processing of the 66-kDa form of AMA-1, only polyclonal IgG caused its anomalous processing, inhibited its redistribution, and cross-linked soluble forms of AMA-1 on merozoites. Moreover, Fab fragments of polyclonal IgG that fail to cross-link did not show the enhancement of inhibitory effect over intact IgG, as observed in the case of Fab fragments of MAb 4G2dc1. We propose that although blocking of biologically important sites is a common direct mode of action of anti-AMA-1 antibodies, blocking of AMA-1 secondary processing and redistribution are additional indirect inhibitory mechanisms by which polyclonal IgG inhibits invasion. We also report a processing inhibition assay that uses a C-terminal AMA-1-specific MAb, 28G2dc1, to detect merozoite-bound remnants of processing (similar to 20 kDa from normal processing to 48 and 44 kDa and similar to 10 kDa from anomalous processing to a 52-kDa soluble form of AMA-1). The ratio of intensity of 10-kDa bands to the sum of 10- and 20-kDa bands was positively correlated with inhibition of invasion by polyclonal antibodies. This assay may serve as an important immunochemical correlate for inhibition of invasion. C1 Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. Biomed Primate Res Ctr, Dept Parasitol, Rijswijk, Netherlands. RP Dutta, S (reprint author), Walter Reed Army Inst Res, Dept Immunol, Rm 3W53,503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Sheetij.dutta@na.amedd.army.mil RI Lanar, David/B-3560-2011; OI Barbosa, Arnoldo/0000-0001-8652-7396 NR 27 TC 39 Z9 41 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2005 VL 73 IS 4 BP 2116 EP 2122 DI 10.1128/IAI.73.4.2116-2122.2005 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 911BB UT WOS:000227975000024 PM 15784553 ER PT J AU Parent, MA Berggren, KN Mullarky, IK Szaba, FM Kummer, LW Adamovicz, JJ Smiley, ST AF Parent, MA Berggren, KN Mullarky, IK Szaba, FM Kummer, LW Adamovicz, JJ Smiley, ST TI Yersinia pestis V protein epitopes recognized by CD4 T cells SO INFECTION AND IMMUNITY LA English DT Article ID ANTIGEN FUSION PEPTIDE; MONOCLONAL-ANTIBODIES; ACTIVE IMMUNIZATION; GAMMA-INTERFERON; PASSIVE-IMMUNITY; PLAGUE VACCINES; PROTECTION; MICE; ENTEROCOLITICA; MOUSE AB Pneumonic plague, an often-fatal disease for which no vaccine is presently available, results from pulmonary infection by the bacterium Yersinia pestis. The Y. pestis V protein is a promising vaccine candidate, as V protein immunizations confer to mice significant protection against aerosolized Y. pestis. CD4 T cells play central roles during vaccine-primed immune responses, but their functional contributions to Y. pestis vaccines have yet to be evaluated and optimized. Toward that end, we report here the identification of three distinct epitopes within the Y. pestis V protein that activate CD4 T cells in C57BL/6 mice. To our knowledge, these are the first identified CD4 T-cell epitopes in any Y. pestis protein. The epitopes are restricted by the I-A(b) class II major histocompatibility complex molecule and are fully conserved between Y. pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica. Immunizing mice with a V protein-containing vaccine or with short peptides containing the identified epitopes primes antigen-specific production of interleukin 2 and gamma interferon by CD4 T cells upon their restimulation in vitro. Consistent with prior studies documenting protective roles for CD4 T cells during Y. enterocolitica infection, vaccinating mice with a 16-amino-acid peptide encoding one of the epitopes suffices to protect against an otherwise lethal Y. enterocolitica challenge. The identification of these epitopes will permit quantitative assessments of V-specific CD4 T cells, thereby enabling researchers to evaluate and optimize the contribution of these cells to vaccine-primed protection against pneumonic plague. C1 Trudeau Inst, Saranac Lake, NY 12983 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Smiley, ST (reprint author), Trudeau Inst, 154 Algonquin Ave, Saranac Lake, NY 12983 USA. EM ssmiley@trudeauinstitute.org RI Mullarky, Isis/A-4007-2009 FU NIAID NIH HHS [U54 AI057158, R56 AI061577, R21 AI054595-02, AI054595, R21 AI054595, R21 AI054595-01, AI061577, AI057158, R01 AI061577] NR 34 TC 24 Z9 27 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2005 VL 73 IS 4 BP 2197 EP 2204 DI 10.1128/IAI.73.4.2197-2204.2005 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 911BB UT WOS:000227975000034 PM 15784563 ER PT J AU Roy, CJ Warfield, KL Welcher, BC Gonzales, RF Larsen, T Hanson, J David, CS Krakauer, T Bavari, S AF Roy, CJ Warfield, KL Welcher, BC Gonzales, RF Larsen, T Hanson, J David, CS Krakauer, T Bavari, S TI Human leukocyte antigen-DQ8 transgenic mice: a model to examine the toxicity of aerosolized staphylococcal enterotoxin B SO INFECTION AND IMMUNITY LA English DT Article ID BIOLOGICAL WARFARE AGENTS; PYROGENIC EXOTOXIN-A; CLASS-II MOLECULE; LETHAL SHOCK; BACTERIAL SUPERANTIGENS; CLINICAL RECOGNITION; BODY-TEMPERATURE; IMMUNE-RESPONSE; VACCINES; LIPOPOLYSACCHARIDE AB Staphylococcal enterotoxins (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especially when delivered as an aerosol. SEs elicit the release of lethal amounts of cytokines by binding to major histocompatibility complex (MHC) class II and cross-linking susceptible T-cell receptors. Efforts to develop effective therapeutic strategies to protect against SEs delivered as an aerosol have been hampered by the lack of small animal models that consistently emulate human responses to these toxins. Here, we report that human leukocyte antigen-DQ8 (HLA-DQ8) transgenic (Tg) mice, but not littermate controls, succumbed to lethal shock induced by SEB aerosols without potentiation. Substantial amounts of perivascular edema and inflammatory infiltrates were noted in the lungs of Tg mice, similar to the pathology observed in nonhuman primates exposed by aerosol to SEB. Furthermore, the observed pathologies and lethal shock correlated with an upsurge in proinflammatory cytokine mRNA gene expression in the lungs and spleens, as well as with marked increases in the levels of proinflammatory circulating cytokines in the Tg mice. Unlike the case for littermate controls, telemetric evaluation showed significant hypothermia in Tg mice exposed to lethal doses of SEB. Taken together, these results show that this murine model will allow for the examination of therapeutics and vaccines developed specifically against SEB aerosol exposure and possibly other bacterial superantigens in the context of human MHC class II receptors. C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. Mayo Clin, Dept Immunol, Rochester, MN USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM bavaris@ncifcrf.gov FU NIAID NIH HHS [AI14764, R01 AI014764, R37 AI014764] NR 39 TC 28 Z9 28 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2005 VL 73 IS 4 BP 2452 EP 2460 DI 10.1128/IAI.73.4.2452-2460.2005 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 911BB UT WOS:000227975000062 PM 15784591 ER PT J AU Kiker, GA Bridges, TS Varghese, A Seager, TP Linkov, I AF Kiker, Gregory A. Bridges, Todd S. Varghese, Arun Seager, Thomas P. Linkov, Igor TI Application of Multicriteria Decision Analysis in Environmental Decision Making SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Review DE Decision criteria; Environmental risk assessment; Site remediation AB Decision making in environmental projects can be complex and seemingly intractable, principally because of the inherent trade-offs between sociopolitical, environmental, ecological, and economic factors. The selection of appropriate remedial and abatement strategies for contaminated sites, land use planning, and regulatory processes often involves multiple additional criteria such as the distribution of costs and benefits, environmental impacts for different populations, safety, ecological risk, or human values. Some of these criteria cannot be easily condensed into a monetary value, partly because environmental concerns often involve ethical and moral principles that may not be related to any economic use or value. Furthermore, even if it were possible to aggregate multiple criteria rankings into a common unit, this approach would not always be desirable because the ability to track conflicting stakeholder preferences may be lost in the process. Consequently, selecting from among many different alternatives often involves making trade-offs that fail to satisfy 1 or more stakeholder groups. Nevertheless, considerable research in the area of multicriteria decision analysis (MCDA) has made available practical methods for applying scientific decision theoretical approaches to complex multicriteria problems. This paper presents a review of the available literature and provides recommendations for applying MCDA techniques in environmental projects. A generalized framework for decision analysis is proposed to highlight the fundamental ingredients for more structured and tractable environmental decision making. C1 [Kiker, Gregory A.; Bridges, Todd S.] US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Varghese, Arun] ICF Consulting, Lexington, MA 02421 USA. [Seager, Thomas P.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47905 USA. [Linkov, Igor] Cambridge Environm, Cambridge, MA 02141 USA. RP Kiker, GA (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM gregory.a.kiker@erdc.usace.army.mil FU USACE Hazard/Risk Focus Area of the Environmental Quality Technology Program; Center for Contaminated Sediments; National Oceanic and Atmospheric Administration through the Cooperative Institute for Coastal and Estuarine Environmental Technology FX The authors are grateful to Cooke, Small, Valverde, Gloria, Yoe, Florig, Sullivan, Dortch, Dyer, and Gardner for their review and suggestions. Special thanks to Stahl for making her dissertation available. Support for this study was provided by the USACE Hazard/Risk Focus Area of the Environmental Quality Technology Program and the Center for Contaminated Sediments. Additional support was provided by the National Oceanic and Atmospheric Administration through the Cooperative Institute for Coastal and Estuarine Environmental Technology. Permission was granted by the USACE Chief of Engineers to publish this material. NR 89 TC 206 Z9 221 U1 7 U2 46 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD APR PY 2005 VL 1 IS 2 BP 95 EP 108 DI 10.1897/IEAM_2004a-015.1 PG 14 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA V43WN UT WOS:000209711600001 PM 16639891 ER PT J AU Steevens, JA Reiss, MR Pawlisz, AV AF Steevens, Jeffery A. Reiss, Mark R. Pawlisz, Andrew V. TI A Methodology for Deriving Tissue Residue Benchmarks for Aquatic Biota: A Case Study for Fish Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Equivalents SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Tissue residue benchmarks; 2,3,7,8-TCDD; Toxicity equivalent quotient; Species sensitivity distributions AB Tissue residue-based toxicity benchmarks (TRBs) have typically been developed using the results of individual studies selected from the literature. In the past, TRBs have been developed using a point estimate (e.g., LC50 value) reported in a study on a single species deemed to be most closely related to the receptor of interest. Despite attempts to maximize the protectiveness and relevance of TRBs, their relationship to specific receptors remains uncertain, and their general applicability for use in broader ecological risk assessment contexts is limited. This article proposes a novel framework that establishes benchmarks as distributions rather than single-point estimates. Benchmark distributions allow the user to select a tissue concentration that is associated with the protection of a specific percentage of organisms, rather than linked to a specific receptor. A methodology is proposed for searching, reviewing, and analyzing linked, tissue residue effect data to derive benchmark distributions. The approach is demonstrated for contaminants having a dioxin-like mechanism of toxic action and is based on residue effects data for 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and equivalents in early life stage fish. The calculated tissue residue benchmarks for 2,3,7,8-TCDD toxic equivalency (TEQ) derived from the resulting distribution could range from 0.057- to 0.699-ng TCDD/g lipid depending on the level of protection needed; the lower estimate is protective of 99% of fish species whereas the higher end is protective of 90% of fish species. C1 [Steevens, Jeffery A.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Waterways Expt Stn,CEERD EP R, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Reiss, Mark R.] US EPA, New York, NY 10007 USA. [Pawlisz, Andrew V.] Cadmus Grp, Watertown, MA 02472 USA. RP Steevens, JA (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Waterways Expt Stn,CEERD EP R, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jeffery.a.steevens@erdc.usace.army.mil FU USEPA, Region 2; U.S. Army Corps of Engineers; U.S. Army Corps of Engineers, New York district FX The authors would like to thank Tala Henry and Phil Cook for their technical advice in the development of technical concepts and review of an early draft of the manuscript. Funding for this work was provided, in part, by USEPA, Region 2, the U.S. Army Corps of Engineers, Dredging Operations Technical Support (program manager, Doug Clarke), and the U.S. Army Corps of Engineers, New York district. NR 46 TC 17 Z9 24 U1 2 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD APR PY 2005 VL 1 IS 2 BP 142 EP 151 DI 10.1897/IEAM_2004a-014.1 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA V43WN UT WOS:000209711600006 PM 16639896 ER PT J AU Meyerle, JH Krivda, SJ Hawkes, CA Norton, SA AF Meyerle, JH Krivda, SJ Hawkes, CA Norton, SA TI An outbreak of urticaria among soldiers deploying for combat SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Letter C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Meyerle, JH (reprint author), Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD APR PY 2005 VL 44 IS 4 BP 347 EP 347 DI 10.1111/j.1365-4632.2004.02107.x PG 1 WC Dermatology SC Dermatology GA 916MF UT WOS:000228389100023 PM 15811098 ER PT J AU O'Brien, C AF O'Brien, C TI Reproducibility of the cold-induced vasodilation response in the human finger SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE vasoconstriction; blood flow; laser-Doppler ID SKIN TEMPERATURE; ARTERIOVENOUS ANASTOMOSES; SYMPATHETIC-STIMULATION; RAYNAUDS-PHENOMENON; BLOOD-FLOW; EXPOSURE; WATER; ACCLIMATION; PERCEPTION; IMMERSION AB Cold-induced vasodilation (CIVD) is a cyclic oscillation in blood flow that occurs in the extremities on cold exposure and that is likely associated with reduced risk of cold injury ( e. g., frostbite) as well as improved manual dexterity and less pain while working in the cold. The CIVD response varies between individuals, but the within-subject reproducibility has not been adequately described. The purpose of this study was to quantify the within-subject variability in the CIVD response under standardized conditions. Twenty-one volunteers resting in a controlled environment ( 27 degrees C) immersed the middle finger in warm water ( 42 degrees C) for 15 min to standardize initial finger temperature and then in cold water ( 4 degrees C; CWI) for 30 min, on five separate occasions. Skin temperature (T-f) and blood flow (laser-Doppler; expressed as percent change from warm-water peak) responses that describe CIVD were identified, including initial nadir reached during CWI, onset time of CIVD, initial apex during CIVD, time of that apex, and overall mean during CWI. Within-subject coefficient of variation for Tf across the five tests for the nail bed and pad, respectively, were as follows: nadir, 9 and 21%; onset, 18 and 19%; apex, 12 and 17%; apex time, 23 and 24%; mean 10 and 15%. For blood flow, these values were as follows: nadir 52 and 64%; onset, 6 and 5%; apex, 33 and 31%; apex time 9 and 8%; and mean 43 and 34%. Greater variability was found in the temperature response of the finger pad than the nail bed, but for blood flow the variability was similar between locations. Variability in onset and apex time between sites was similar for both temperature and blood flow responses. The reproducibility of the time course of CIVD suggests this methodology may be of value for further studies examining the mechanism of the response. C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP O'Brien, C (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. EM kate.obrien@us.army.mil NR 32 TC 35 Z9 35 U1 2 U2 8 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD APR PY 2005 VL 98 IS 4 BP 1334 EP 1340 DI 10.1152/japplphysiol.00859.2004 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 906TE UT WOS:000227665400026 PM 15579576 ER PT J AU Medina, VF Larson, SL Extine, B Bednar, A AF Medina, VF Larson, SL Extine, B Bednar, A TI Perchlorate analysis using solid-phase extraction cartridges SO JOURNAL OF CHROMATOGRAPHIC SCIENCE LA English DT Article ID ION CHROMATOGRAPHY; MASS-SPECTROMETRY; WATERS C1 USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS USA. Appl Res Associates Inc, So Div, Vicksburg, MS 39180 USA. RP Medina, VF (reprint author), USA, Environm Lab, Engn Res & Dev Ctr, 3909 Hall Ferry Rd, Vicksburg, MS USA. NR 23 TC 3 Z9 3 U1 2 U2 6 PU PRESTON PUBLICATIONS INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0021-9665 J9 J CHROMATOGR SCI JI J. Chromatogr. Sci. PD APR PY 2005 VL 43 IS 4 BP 195 EP 200 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 921TL UT WOS:000228787800006 PM 15975235 ER PT J AU Zhou, K Guo, JR You, C Mayega, J Kraft, RP Zhang, T McDonald, JF Goda, BS AF Zhou, K Guo, JR You, C Mayega, J Kraft, RP Zhang, T McDonald, JF Goda, BS TI Multi-GHz sige BiCMOS FPGAs with new architecture and novel power management techniques SO JOURNAL OF CIRCUITS SYSTEMS AND COMPUTERS LA English DT Article DE FPGA; SiGe; CML; power management; X-pattern decoding ID TECHNOLOGY AB The availability of Silicon Germanium (SiGe) Heterojunction Bipolar Transistor (HBT) devices has opened a door for GHz Field Programmable Gate Arrays (FPGAs).(1,2) The integration of high-speed Site HBTs and low-power CMOS gives a significant speed advantage to SiGe FPGAs over CMOS FPGAs. In the past, high static power consumption discouraged the pursuit of bipolar FPGAs from being scaled up significantly. This paper details new ideas to reduce power in designing high-speed SiGe BiCMOS FPGAs. The paper explains new methods to reduce circuitry and utilize a novel power management scheme to achieve a flexible trade-off between power consumption and circuit speed. In addition, new decoding logic is developed with shared address and data lines. A SiGe FPGA test chip based on the Xilinx 6200 architecture has been fabricated for demonstration. C1 Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Zhou, K (reprint author), Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. EM zhouk@rpi.edu NR 15 TC 1 Z9 1 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-1266 J9 J CIRCUIT SYST COMP JI J. Circuits Syst. Comput. PD APR PY 2005 VL 14 IS 2 BP 179 EP 193 DI 10.1142/S0218126605002234 PG 15 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 951NL UT WOS:000230937300001 ER PT J AU Juang, YT Wang, Y Solomou, EE Li, YS Mawrin, C Tenbrock, K Kyttaris, VC Tsokos, C AF Juang, YT Wang, Y Solomou, EE Li, YS Mawrin, C Tenbrock, K Kyttaris, VC Tsokos, C TI Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article ID DEPENDENT PROTEIN-KINASE; P70 S6 KINASE; T-CELLS; ACTIVATOR CREM; CD40 LIGAND; SIGNAL-TRANSDUCTION; POSITIVE REGULATION; GENE-EXPRESSION; CROSS-TALK; IV AB Systemic lupus erythematosus (SLE) T cells express high levels of cAMP response element modulator (CREM) that binds to the IL-2 promoter and represses the transcription of the IL-2 gene. This study was designed to identify pathways that lead to increased binding of CREM to the IL-2 promoter in SLE T cells. Ca2+/calmodulin-dependent kinase IV (CaMKIV) was found to be increased in the nucleus of SLE T cells and to be involved in the overexpression of CREM and its binding to the IL-2 promoter. Treatment of normal T cells with SLE serum resulted in increased expression of CREM protein, increased binding of CREM to the IL-2 promoter, and decreased IL-2 promoter activity and IL-2 production. This process was abolished when a dominant inactive form of CaMKIV was expressed in normal T cells. The effect of SLE serum resided within the IgG fraction and was specifically attributed to anti-TCR/CD3 autoandbodies. This study identifies CaMKIV as being responsible for the increased expression of CREM and the decreased production of IL-2 in SLE T cells and demonstrates that anti-TCR/CD3 antibodies present in SLE sera can account for the increased expression of CREM and the suppression of IL-2 production. C1 Walter Reed Army Inst Res, Dept Cellulat Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Washington Hosp Ctr, Dept Med, Rheumatol Sect, Washington, DC 20010 USA. RP Tsokos, C (reprint author), Walter Reed Army Inst Res, Dept Cellulat Injury, Bldg 503,Room 1A32, Silver Spring, MD 20910 USA. EM gtsokos@usuhs.mil FU NIAID NIH HHS [R01 AI042269, R01 AI049954, R01 AI42269, R01 AI49954] NR 45 TC 120 Z9 128 U1 1 U2 3 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD APR PY 2005 VL 115 IS 4 BP 996 EP 1005 DI 10.1172/JCI22854 PG 10 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 913IU UT WOS:000228145700031 PM 15841182 ER PT J AU Krafft, AE Russell, KL Hawksworth, AW McCall, S Irvine, M Daum, LT Connoly, JL Reid, AH Gaydos, JC Taubenberger, JK AF Krafft, AE Russell, KL Hawksworth, AW McCall, S Irvine, M Daum, LT Connoly, JL Reid, AH Gaydos, JC Taubenberger, JK TI Evaluation of PCR testing of ethanol-fixed nasal swab specimens as augmented surveillance strategy for influenza virus and adenovirus identification SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID REVERSE TRANSCRIPTION-PCR; ACUTE RESPIRATORY-DISEASE; POLYMERASE-CHAIN-REACTION; RT-PCR; RAPID DETECTION; US MILITARY; B VIRUSES; TIME; SAMPLES; ASSAY AB Viral culture isolation has been widely accepted as the "gold standard" for laboratory confirmation of viral infection; however, it requires ultralow temperature specimen storage. Storage of specimens in ethanol at room temperature could expand our ability to conduct active surveillance and retrospective screenings of viruses with rapid and inexpensive real-time PCR tests, including isolates from remote regions where freezing specimens for culture is not feasible. Molecular methods allow for rapid identification of viral pathogens without the need to maintain viability. We hypothesized that ethanol, while inactivating viruses, can preserve DNA and RNA for PCR-based methods. To evaluate the use of ethanol-stored specimens for augmenting surveillance for detection of influenza viruses A and B and adenoviruses (AdV), paired nasal swab specimens were collected from 384 recruits with febrile respiratory illness at Fort Jackson, S.C., in a 2-year study. One swab was stored at ambient temperature in 100% ethanol for up to 6 months, and the other swab was stored at -70 degrees C in viral medium. For viral detection, frozen specimens were cultured for a variety of respiratory viruses, and ethanol-fixed specimens were tested with TaqMan (TM) probe and LightCycler SYBR green (SG) melting curve assays with at least two different PCR targets for each virus. The sensitivities of the TM and SG assays on specimens stored in ethanol for 1 month were 75% and 58% for influenza A, 89% and 67% for influenza B, and 93 to 98% and 57% for AdV, respectively. Lower specificities of the real-time assays corresponded to the increased detection of PCR-positive but culture-negative specimens. Influenza virus RNA was detected as well or better after 6 months of storage in ethanol. C1 Armed Forces Inst Pathol, Dept Mol Pathol, Rockville, MD 20850 USA. USN, Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, San Diego, CA 92152 USA. Mol Virol Branch, Brooks City Base, TX USA. Moncrief Army Hosp, Ft Jackson, SC USA. Walter Reed Army Inst Res, DoD Global Emerging Infect Surveillance & Respons, Silver Spring, MD USA. RP Krafft, AE (reprint author), Armed Forces Inst Pathol, Dept Mol Pathol, 1413 Res Blvd, Rockville, MD 20850 USA. EM A.Krafft@afip.osd.mil NR 50 TC 39 Z9 39 U1 1 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2005 VL 43 IS 4 BP 1768 EP 1775 DI 10.1128/JCM.43.4.1768-1775.2005 PG 8 WC Microbiology SC Microbiology GA 916RS UT WOS:000228404100040 PM 15814997 ER PT J AU Frazier, RM Thaler, GT Gila, BP Stapleton, J Overberg, ME Abernathy, OR Pearton, SJ Ren, F Zavada, JM AF Frazier, RM Thaler, GT Gila, BP Stapleton, J Overberg, ME Abernathy, OR Pearton, SJ Ren, F Zavada, JM TI AlN-based dilute magnetic semiconductors SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE AlMnN; AlCrN; magnetic semiconductors ID MOLECULAR-BEAM-EPITAXY; MN-IMPLANTED GAN; ROOM-TEMPERATURE; THIN-FILMS; FERROMAGNETISM; MAGNETOTRANSPORT; BEHAVIOR AB AIMnN and AlCrN have been synthesized by gas-source molecular beam epitaxy (GSMBE). Using optimized growth conditions and compositions, sccm films as determined by x-ray diffraction (XRD) and transmission electron microscopy, which also show room-temperature magnetic behavior were obtained for both materials. Chromium was found to produce greater magnetic ordering as evidenced by a higher technical saturation. The AlCrN also exhibited a higher remanent magnetization and a M versus T behavior more typical of ferromagnetism than that observed for AIMnN. These results suggest that Cr is a superior dopant for formation of AIN-based, dilute magnetic semiconductors. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Frazier, RM (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.ulf.edu NR 27 TC 8 Z9 8 U1 0 U2 6 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD APR PY 2005 VL 34 IS 4 BP 365 EP 369 DI 10.1007/s11664-005-0112-7 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 919QP UT WOS:000228633000011 ER PT J AU Wiegand, DA Reddingius, B AF Wiegand, DA Reddingius, B TI Mechanical properties of confined explosives SO JOURNAL OF ENERGETIC MATERIALS LA English DT Article DE confinement; pressure; flow stress; modulus; work hardening; work softening; plastic bonded explosive; crack; fracture; plastic deformation; mechanical properties ID POROSITY AB The mechanical properties of composite explosives are being studied as a function of mechanical confinement. Although other techniques for confinement were used, most of the results presented here were obtained by the use of a constant confining pressure obtained by oil immersion. While many energetic materials fail by crack processes when unconfined, with all of the forms of confinement used here they appear to fail by plastic flow. For crystalline explosives, for example, TNT and composition B, the yield strength and the modulus are independent of confining pressure. However, for materials containing polymer binders such as plastic-bonded explosives, these properties are found to significantly increase with pressure. C1 USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Wiegand, DA (reprint author), USA, Armament Res Dev & Engn Ctr, Bldg 3022, Picatinny Arsenal, NJ 07806 USA. EM dwiegland@pica.army.mil NR 34 TC 7 Z9 9 U1 1 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0737-0652 J9 J ENERG MATER JI J. Energ. Mater. PD APR-JUN PY 2005 VL 23 IS 2 BP 75 EP 98 DI 10.1080/07370650590936415 PG 24 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical; Materials Science, Multidisciplinary SC Chemistry; Engineering; Materials Science GA 962FI UT WOS:000231716000002 ER PT J AU Simon, D Simon, DL AF Simon, D Simon, DL TI Aircraft turbofan engine health estimation using constrained Kalman filtering SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 49th Gas Turbine Conference (TURBO EXPO 04) CY JUN 14-17, 2004 CL Vienna, AUSTRIA AB Kalman filters are often used to estimate the state variables of a dynamic system. However in the application of Kalman filters some known signal information is often either ignored or dealt with heuristically. For instance, state-variable constraints (which may be based on physical considerations) are often neglected because they do not fit easily into the structure of the Kalman filter This paper develops an analytic method of incorporating state-variable inequality constraints in the Kalman filter. The resultant filter is a combination of a standard Kalman filter and a quadratic programming problem. The incorporation of state-variable constraints increases the computational effort of the filter but significantly improves its estimation accuracy. The improvement is proven theoretically and shown via simulation results obtained from application to a turbofan engine model. This model contains 16 state variables, 12 measurements, and 8 component health parameters. It is shown that the new algorithms provide improved performance in this example over unconstrained Kalman filtering. C1 Cleveland State Univ, Dept Elect Engn, Cleveland, OH 44115 USA. NASA, Glenn Res Ctr, USA, Res Lab, Cleveland, OH 44138 USA. RP Simon, D (reprint author), Cleveland State Univ, Dept Elect Engn, 1960 E 24th St, Cleveland, OH 44115 USA. EM d.j.simon@csuohio.edu; donald.l.simon@grc.nasa.gov NR 20 TC 27 Z9 27 U1 1 U2 3 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD APR PY 2005 VL 127 IS 2 BP 323 EP 328 DI 10.1115/1.1789153 PG 6 WC Engineering, Mechanical SC Engineering GA 926YZ UT WOS:000229160900013 ER PT J AU Provenza, AJ Montague, GT Jansen, MJ Palazzolo, AB Jansen, RH AF Provenza, AJ Montague, GT Jansen, MJ Palazzolo, AB Jansen, RH TI High temperature characterization of a radial magnetic bearing for turbomachinery SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 49th Gas Turbine Conference (TURBO EXPO 04) CY JUN 14-17, 2004 CL Vienna, AUSTRIA AB Open loop, experimental force and power measurements of a radial, redundant-axis, magnetic bearing at temperatures to 1000&DEG; F (538&DEG; C) and rotor speeds to 15,000 rpm along with theoretical temperature and force models are presented in this paper The experimentally measured force produced by a single C-core circuit using 22A was 600 lb (2.67 kN) at room temperature and 380 lb (1.69 kN) at 538&DEG; C. These values were compared withforce predictions based on a one-dimensional magnetic circuit analysis and a thermal analysis of gap growth as a function of temperature. The analysis showed that the reduction of force at high temperature is mostly due to an increase in radial gap due to test conditions, rather than to reduced core permeability. Tests under rotating conditions showed that rotor speed has a negligible effect on the bearing's static force capacity. One C-core required approximately 340 W of power to generate 190 lb (845 N) of magnetic force at 538&DEG; C, however the magnetic air gap was much larger than at room temperature. The data presented are after bearing operation for eleven total hours at 538&DEG; C and six thermal cycles. C1 USA, Res Lab, NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. Univ Toledo, Toledo, OH 43606 USA. Texas A&M Univ, Dept Mech Engn, College Stn, TX USA. RP Provenza, AJ (reprint author), USA, Res Lab, NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. EM andrew.j.provenza@nasa.gov; gerald.t.montague@nasa.gov; mark.j.jansen@nasa.gov; a-palazzolo@tamu.edu; ralph.h.jansen@nasa.gov NR 13 TC 5 Z9 6 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD APR PY 2005 VL 127 IS 2 BP 437 EP 444 DI 10.1115/1.1807413 PG 8 WC Engineering, Mechanical SC Engineering GA 926YZ UT WOS:000229160900027 ER PT J AU Cheng, M Chen, WN Weerasooriya, T AF Cheng, M Chen, WN Weerasooriya, T TI Mechanical properties of Kevlar (R) KM2 single fiber SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID ANISOTROPIC FIBRE MONOFILAMENTS; COMPRESSION AB Kevlar(R) KM2 fiber is a transversely isotropic material. Its tensile stress-strain response in the axial direction is linear and elastic until failure. However, the overall deformation in the transverse directions is nonlinear and nonelastic, although it can be treated linearly and elastically in infinitesimal strain range. For a linear, elastic, and transversely isotropic material, five material constants are needed to describe its stress-strain response. In this paper, stress-strain behavior obtained from experiments on a single Kevlar KM2 fiber are presented and discussed. The effects of loading rate and the influence of axial loading on transverse and transverse loading on axial stress-strain responses are also discussed. C1 Univ Arizona, Dept Aerosp & Mech Engn, Tucson, AZ 85721 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Cheng, M (reprint author), Univ Arizona, Dept Aerosp & Mech Engn, Tucson, AZ 85721 USA. EM weinong@u.arizona.edu NR 19 TC 104 Z9 107 U1 5 U2 49 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD APR PY 2005 VL 127 IS 2 BP 197 EP 203 DI 10.1115/1.1857937 PG 7 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 923YS UT WOS:000228946100006 ER PT J AU Dezee, KJ Shimeall, WT Douglas, K Shumway, N O'Malley, PG AF Dezee, KJ Shimeall, WT Douglas, K Shumway, N O'Malley, PG TI Treatment of excessive anticoagulation with vitamin K: A meta-analysis. SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 28th Annual Meeting of the Society-of-General-Internal-Medicine CY MAY 11-14, 2005 CL New Orleans, LA SP Soc General Internal Med C1 Walter Reed Army Med Ctr, Bethesda, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Chevy Chase, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2005 VL 20 SU 1 BP 74 EP 74 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 922IQ UT WOS:000228831000171 ER PT J AU Dezee, K O'Malley, PG Taylor, AJ Jackson, JL Reed, W AF Dezee, K O'Malley, PG Taylor, AJ Jackson, JL Reed, W TI Determinants of subclinical atherosclerosis using structural equation modeling. SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 28th Annual Meeting of the Society-of-General-Internal-Medicine CY MAY 11-14, 2005 CL New Orleans, LA SP Soc General Internal Med C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2005 VL 20 SU 1 BP 95 EP 95 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 922IQ UT WOS:000228831000244 ER PT J AU Johnson, EN Truesdell, A Villines, T AF Johnson, EN Truesdell, A Villines, T TI Are fad diets for everyone? Symptomatic hyponatremia with a lowcarbohydrate diet SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 28th Annual Meeting of the Society-of-General-Internal-Medicine CY MAY 11-14, 2005 CL New Orleans, LA SP Soc General Internal Med C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2005 VL 20 SU 1 BP 232 EP 232 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 922IQ UT WOS:000228831001335 ER PT J AU Hayden, PJ Petrali, JP Hamilton, TA Kubilus, J Smith, WJ Klausner, M AF Hayden, PJ Petrali, JP Hamilton, TA Kubilus, J Smith, WJ Klausner, M TI Development of a full thickness in vitro human skin equivalent (EpiDerm-FT) for sulfur mustard research SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT 66th Annual Meeting of the Society-for-Investigative-Dermatology CY MAY 04-07, 2005 CL St Louis, MO SP Soc Investigat Dermatol C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. MatTek Corp, Ashland, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2005 VL 124 IS 4 SU S MA 174 BP A29 EP A29 PG 1 WC Dermatology SC Dermatology GA 913UT UT WOS:000228179900174 ER PT J AU Grujicic, M Cao, G Roy, WN AF Grujicic, M Cao, G Roy, WN TI Computational analysis of the lattice contribution to thermal conductivity of single-walled carbon nanotubes SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID MOLECULAR-DYNAMICS; SIMULATION; TRANSPORT; HEAT AB Molecular dynamics based heat-flux auto-correlation functions are combined with a Green-Kubo relation from the linear response theory to quantify the lattice contribution to thermal conductivity of single-walled carbon nanotubes with three different chiralities (screw symmetries). The interactions between carbon atoms within a nanotube are analyzed using the Adaptive Intermolecular Reactive Empirical Bond Order (AIREBO) potential. The results obtained show that, due to a long-term exponential-decay character of the heat-flux auto-correlation functions, converging values of the lattice thermal conductivities can be obtained using computational cells considerably smaller than the phonon mean free path. However, to obtain accurate values of the thermal conductivity, a spectral Green-Kubo relation and a phonon-based extrapolation function are found to be instrumental for quantifying the thermal conductivity contribution of the long-wavelength phonons not allowed in the computational cells of a finite size. The results further show that chirality of the carbon nanotubes can affect the lattice contribution to the thermal conductivity by as much as 20%. Also, the simulation results of the effect of temperature on the thermal conductivity clearly show a competition between an increase in the number of phonons and an increased probability for phonon scattering at higher temperatures. (C) 2005 Springer Science + Business Media, Inc. C1 Clemson Univ, Dept Mech Engn, Program Mat Sci & Engn, Clemson, SC 29634 USA. USA, Res Lab, WMRD AMSRL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Program Mat Sci & Engn, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu RI Cao, guoxin/A-9790-2012 OI Cao, guoxin/0000-0002-6598-2899 NR 29 TC 37 Z9 39 U1 0 U2 6 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD APR PY 2005 VL 40 IS 8 BP 1943 EP 1952 DI 10.1007/s10853-005-1215-5 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA 923QG UT WOS:000228923800013 ER PT J AU Correa-Cerro, LS Wassif, CA Waye, JS Krakowiak, PA Cozma, D Dobson, NR Levin, SW Anadiotis, G Steiner, RD Krajewska-Walasek, M Nowaczyk, MJM Porter, FD AF Correa-Cerro, LS Wassif, CA Waye, JS Krakowiak, PA Cozma, D Dobson, NR Levin, SW Anadiotis, G Steiner, RD Krajewska-Walasek, M Nowaczyk, MJM Porter, FD TI DHCR7 nonsense mutations and characterisation of mRNA nonsense mediated decay in Smith-Lemli-Opitz syndrome SO JOURNAL OF MEDICAL GENETICS LA English DT Article ID PREMATURE STOP MUTATIONS; 7-DEHYDROCHOLESTEROL REDUCTASE GENE; CHOLESTEROL-BIOSYNTHESIS; CARRIER FREQUENCY; CYSTIC-FIBROSIS; CFTR FUNCTION; PHENOTYPE; DIAGNOSIS; DISEASE; PLASMA C1 NICHD, Heritable Disorders Branch, NIH, DHHS,Unit Mol Dysmorphol, Bethesda, MD 20892 USA. McMaster Univ, Dept Pathol & Mol Med & Pediat, Hamilton, ON, Canada. Natl Naval Med Res Inst, Dept Pediat, Bethesda, MD USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Legacy Childrens Hosp, Portland, OR USA. Oregon Hlth & Sci Univ, Doernbecher Childrens Hosp, Child Dev Rehabil Ctr, Dept Pediat, Portland, OR USA. Oregon Hlth & Sci Univ, Doernbecher Childrens Hosp, Child Dev Rehabil Ctr, Dept Mol & Med Genet, Portland, OR USA. Childrens Mem Hlth Inst, Dept Med Genet, Warsaw, Poland. RP Porter, FD (reprint author), NICHD, Heritable Disorders Branch, NIH, DHHS,Unit Mol Dysmorphol, Bld 10,Rm 9S241,10 Ctr Dr, Bethesda, MD 20892 USA. EM fdporter@mail.nih.gov OI Steiner, Robert/0000-0003-4177-4590; Wassif, Christopher/0000-0002-2524-1420 NR 37 TC 21 Z9 22 U1 0 U2 5 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0022-2593 J9 J MED GENET JI J. Med. Genet. PD APR PY 2005 VL 42 IS 4 BP 350 EP 357 DI 10.1136/jmg.2004.022749 PG 8 WC Genetics & Heredity SC Genetics & Heredity GA 912JV UT WOS:000228074900010 PM 15805162 ER PT J AU Doughty, RA AF Doughty, RA TI "Who will be master of the world, must be master of the air": The creation of French military aviation. SO JOURNAL OF MILITARY HISTORY LA French DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Doughty, RA (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2005 VL 69 IS 2 BP 576 EP 577 DI 10.1353/jmh.2005.0086 PG 2 WC History SC History GA 912ME UT WOS:000228081800042 ER PT J AU Swain, IM AF Swain, IM TI Winning modern wars: Iraq, terrorism, and the American empire. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Swain, IM (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2005 VL 69 IS 2 BP 611 EP 612 PG 2 WC History SC History GA 912ME UT WOS:000228081800068 ER PT J AU Smith, A Madden, KB Yeung, KJA Zhao, AP Elfrey, J Finkelman, F Levander, O Shea-Donohue, T Urban, JF AF Smith, A Madden, KB Yeung, KJA Zhao, AP Elfrey, J Finkelman, F Levander, O Shea-Donohue, T Urban, JF TI Deficiencies in selenium and/or vitamin E lower the resistance of mice to Heligmosomoides polygyrus infections SO JOURNAL OF NUTRITION LA English DT Article DE selenium; vitamin E; parasite; immunity; gastrointestinal ID NF-KAPPA-B; NEMATODE-INDUCED ALTERATIONS; T-CELLS; PROTECTIVE IMMUNITY; GLUTATHIONE-PEROXIDASE; TRANSCRIPTION FACTOR; LIPID-PEROXIDATION; COXSACKIEVIRUS B3; GENE-EXPRESSION; IN-VITRO AB Previous studies have shown that deficiencies in selenium (Se) and/or vitamin E(VE) can exacerbate the infectivity and pathogenesis of coxsackievirus B3 and influenza. Both Se and VE play a role in immune function and antioxidant defense. To determine whether these deficiencies would affect the normal course of infection with a metazoan parasite, mice were made deficient in Se and/or VE and inoculated with the gastrointestinal nematode parasite Heligmosomoides polygyrus. Both primary and secondary infections were assessed. Although the course of a primary infection with H. polygyrus was unaffected by diet, diets deficient in Se, VE, and both Se and VE (Se/VE double-deficiency) all caused delayed adult worm expulsion and increased fecundity during a secondary infection; suggesting an impaired intestinal response. H. polygyrus-induced IL-4 levels were diet-independent; but Se/VE double-deficiency blocked the H. polygyrus-induced IL-4 receptor-associated decrease in sodium-dependent glucose absorption in the jejunum that contributes to worm expulsion. In contrast, Se/VE double-deficiency had no effect on the infection-induced, IL-4R-associated increase in epithelial cell permeability that accompanies the infection. These results suggest that both Se and VE are required for specific IL-4-related changes in intestinal physiology that promote host protection against H. polygyrus. C1 USDA, ARS, Beltsville Human Nutr Res Ctr, Nutrient Requirements & Funct Lab, Beltsville, MD 20705 USA. Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Univ Cincinnati, Cincinnati Childrens Hosp, Coll Med, Ctr Med, Cincinnati, OH USA. Cincinnati Vet Adm Med Ctr, Cincinnati, OH USA. RP Urban, JF (reprint author), USDA, ARS, Beltsville Human Nutr Res Ctr, Nutrient Requirements & Funct Lab, Beltsville, MD 20705 USA. EM urbanj@ba.ars.usda.gov OI Urban, Joseph/0000-0002-1590-8869 NR 49 TC 22 Z9 25 U1 0 U2 1 PU AMER INST NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 J9 J NUTR JI J. Nutr. PD APR PY 2005 VL 135 IS 4 BP 830 EP 836 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 913KD UT WOS:000228149500028 PM 15795443 ER PT J AU Adler, AB Huffman, AH Bliese, PD Castro, CA AF Adler, Amy B. Huffman, Ann H. Bliese, Paul D. Castro, Carl Andrew TI The impact of deployment length and experience on the well-being of male and female soldiers SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY LA English DT Article; Proceedings Paper CT 108th Annual Convention of the American-Psychological-Association CY AUG 04-08, 2000 CL WASHINGTON, DC SP Amer Psychol Assoc ID POSTTRAUMATIC-STRESS-DISORDER; WORK-FAMILY CONFLICT; PERSIAN-GULF-WAR; US ARMY SOLDIERS; GENDER-DIFFERENCES; RISK-FACTORS; OCCUPATIONAL STRESS; COPING STYLES; VETERANS; ROLES AB This study examined the effects of stressor duration (deployment length) and stressor novelty (no prior deployment experience) on the psychological health of male and female military personnel returning from a peacekeeping deployment. The sample consisted of men (n = 2,114) and women (n = 1,225) surveyed for symptoms of depression and posttraumatic stress. The results confirmed the hypotheses. Longer deployments and 1st-time deployments were associated with an increase in distress scores. However, the relationship between deployment length and increased distress was found only for male soldiers. The findings demonstrate the importance of considering the impact of exposure to long-term occupational stressors and confirm, in part, previous research that has demonstrated a different stress response pattern for men and women. C1 USA, Med Res Unit, APO, AE 09042 USA. Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA. RP Adler, AB (reprint author), USA, Med Res Unit, APO, AE 09042 USA. EM amy.adler@us.army.mil NR 63 TC 71 Z9 71 U1 3 U2 17 PU AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1076-8998 J9 J OCCUP HEALTH PSYCH JI J. Occup. Health Psychol. PD APR PY 2005 VL 10 IS 2 BP 121 EP 137 DI 10.1037/1076-8998.10.2.121 PG 17 WC Public, Environmental & Occupational Health; Psychology, Applied SC Public, Environmental & Occupational Health; Psychology GA 098PQ UT WOS:000241535700004 PM 15826223 ER PT J AU Sullivan, JS Bounngaseng, A Stewart, A Sullivan, JJ Galland, GG Henry, F Collins, WE AF Sullivan, JS Bounngaseng, A Stewart, A Sullivan, JJ Galland, GG Henry, F Collins, WE TI Infection of Saimiri boliviensis monkeys with Plasmodium coatneyi SO JOURNAL OF PARASITOLOGY LA English DT Article ID HUMAN CEREBRAL MALARIA; RHESUS-MONKEYS; MACACA-MULATTA; PRIMATE MODEL; EXOERYTHROCYTIC STAGES; SIMIAN MALARIA; AOTUS; TRANSMISSION; INUI; SCIUREUS AB Abundant, apparently normally developing, liver-stage parasites of Plasmodium coatneyi were demonstrated following injection of sporozoites dissected from the salivary glands of Anopheles dirus mosquitoes. Erythrocytic development was not demonstrated. C1 Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA USA. Ctr Dis Control & Prevent, Sci Resources Program, Natl Ctr Infect Dis, Atlanta, GA USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. Atlanta Res & Educ Fdn, Atlanta, GA USA. RP Collins, WE (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA USA. EM wec1@cdc.gov NR 24 TC 4 Z9 4 U1 0 U2 1 PU AMER SOC PARASITOLOGISTS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0022-3395 J9 J PARASITOL JI J. Parasitol. PD APR PY 2005 VL 91 IS 2 BP 479 EP 481 DI 10.1645/GE-3461RN PG 3 WC Parasitology SC Parasitology GA 931OH UT WOS:000229494100043 PM 15986634 ER PT J AU Peacock, ME Park, DS Swiec, GD Erley, KJ AF Peacock, ME Park, DS Swiec, GD Erley, KJ TI Perioral angioedema associated with angiotensin-converting enzyme inhibitor SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE angioneurotic edema/etiology; angiotensin-converting enzyme inhibitors; angiotensin receptor blocker; blacks ID RECEPTOR ANTAGONISTS; ANGIONEUROTIC-EDEMA; AMERICANS AB Background: Angioedema is a non-pruritic swelling usually limited to the skin and mucous membranes of the face and perioral soft tissues. It can be life threatening but usually is not, and can be managed with conservative medical treatment unless the airway is endangered. Recent reports suggest that angiotensin-converting enzyme (ACE) inhibitors can predispose and/or precipitate angioedema, with a predilection toward patients of African American ancestry. Methods: This case report involved a 65-year-old African American female who was being treated surgically for localized chronic periodontitis. The procedure was performed without incident, and the patient was alert and stable when released. The next day, the patient called and reported that her lips were swollen. She stated that this had happened a number of times over the past several years, sometimes related to eating shellfish and other times without any known precipitating factor. All previous episodes of perioral swelling occurred after ACE inhibitor therapy had been initiated. Results: The patient was in no distress, with no other site involvement. She was prescribed oral hydroxyzine and her appearance returned to normal after 5 days. Although the patient had experienced previous episodes of angioedema, none had been in response to any dental procedure. She was referred to the Allergy and Immunology Clinic for skin testing, the results of which were negative to shellflsh with good controls. Other potentiating etiologies were also ruled out by the allergist. Conclusions: Angioedema is a recognized possible side effect of ACE inhibitor therapy. The exact mechanism by which ACE inhibitors induce angioedema is not known, although the risk of occurrence is much greater in African Americans. Practitioners should be alert to this potentially fatal condition in patients who take ACE inhibitors or the newer angiotensin II receptor blockers (ARBs). C1 USA, Landstuhl, Germany. USA, Wurzburg, Germany. USA, Fort Gordon, GA USA. RP Peacock, ME (reprint author), Landstuhl Reg Med Ctr, CMR 402,Box 67, APO, AE 09180 USA. EM mark.peacock@lnd.amedd.army.mil NR 27 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 USA SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD APR PY 2005 VL 76 IS 4 BP 651 EP 654 DI 10.1902/jop.2005.76.4.651 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 923AA UT WOS:000228879800022 PM 15857108 ER PT J AU Schaaf, RV Klosky, JL AF Schaaf, RV Klosky, JL TI Classroom demonstrations in introductory mechanics SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article C1 USA, Acquisit Corps, Huntsville, AL USA. US Mil Acad, Dept Civil Engn & Mech, W Point, NY 10996 USA. RP Schaaf, RV (reprint author), USA, Acquisit Corps, Huntsville, AL USA. EM Reid.Vanderschaaf@us.army.mil; Ledlie.Klosky@usina.edu NR 5 TC 2 Z9 2 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1052-3928 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD APR PY 2005 VL 131 IS 2 BP 83 EP 89 PG 7 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA 908KK UT WOS:000227785700001 ER PT J AU Quadrato, C Welch, RW Albert, BC AF Quadrato, C Welch, RW Albert, BC TI Training faculty to teach civil engineering SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article AB Adoption of ASCE's Policy Statement 465 and subsequent discussion of the what, how, and who of teaching the body of knowledge (BOK) that will be required for professional civil engineering practice has heightened the need for continued improvement in civil engineering education. ASCE has explicitly said the role of educators and practitioners in teaching the body of knowledge is critical and has listed faculty-related success factors for teaching the BOK. A key success factor is statement 465's call for faculty and practitioners to properly prepare to "effectively engage Students in the learning process." This paper considers this challenge and discusses an instructor training program that effectively prepares faculty and practitioners to actively engage students in the learning process as envisioned by Policy Statement 465. We will show quantifiable evidence of the positive results gained by using this instructor training program through student and instructor feedback. Additionally, alternative shorter courses based on this program of preparation are highlighted that may be attended by the faculty of multiple engineering programs and by practitioners. C1 US Mil Acad, Dept Civil & Mech Engn, W Point, NY 10996 USA. RP Quadrato, C (reprint author), US Mil Acad, Dept Civil & Mech Engn, W Point, NY 10996 USA. NR 6 TC 2 Z9 2 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1052-3928 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD APR PY 2005 VL 131 IS 2 BP 111 EP 117 DI 10.1061/(ASCE)1052-3928(2005)131:2(111) PG 7 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA 908KK UT WOS:000227785700007 ER PT J AU Yauger, BJ Dunlow, SG Lockrow, EG AF Yauger, BJ Dunlow, SG Lockrow, EG TI Laparoscopic appendectomy SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE appendectomy; laparoscopic surgery; laparosonic coagulating shears ID ULTRASONICALLY ACTIVATED SCALPEL; LAPAROSONIC COAGULATING SHEARS; CHOLECYSTECTOMY; HYSTERECTOMY; EFFICACY AB OBJECTIVE: To report a series of laparoscopic appendectomies utilizing laparosonic coagulating shears (LCS) (harmonic scalpel). STUDY DESIGN: We conducted a retrospective chart review of all patients who underwent laparoscopic appendectomy at Walter Reed Army Medical Center between January 1, 1996, and December 31, 2001. Procedures were included if only 1 instrument was utilized for transection of the appendix: endoshears, endo-GIA (Tyco U.S. Surgical, Norwalk, Connecticut) or LCS. Procedures on ruptured appendixes and emergency procedures were excluded. Outcome variables of interest included operative time, estimated blood loss, length of hospital stay and complications. RESULTS: Mean estimated blood loss, mean operative times and hospital stay were consistent with those of other techniques of laparoscopic appendectomy. LCS was used more frequently for appendectomy performed at the time of another procedure than were endo-GIA and endoshears. There were no complications in the harmonic scalpel laparoscopic appendectomy series. CONCLUSION: This series demonstrates that laparoscopic appendectomy with LCS has low morbidity and is as efficacious as other methods of laparoscopic appendectomy. C1 Walter Reed Army Med Ctr, Uniformed Serv Residency Obstet & Gynecol, Washington, DC 20307 USA. RP Lockrow, EG (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM Elockrow@usuhs.mil NR 10 TC 4 Z9 4 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD APR PY 2005 VL 50 IS 4 BP 231 EP 234 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 918FT UT WOS:000228528400001 PM 15916204 ER PT J AU Kuklo, TR Potter, BK Lenke, LG AF Kuklo, TR Potter, BK Lenke, LG TI Vertebral rotation and thoracic torsion in adolescent idiopathic scoliosis - What is the best radiographic correlate? SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES LA English DT Article DE adolescent idiopathic scoliosis; vertebral rotation; thoracic torsion; thoracic asymmetry; measurement ID PEDICLE SCREW FIXATION; LONGITUDINAL AXIS ROTATION; RIB CAGE DEFORMITY; COMPUTER-TOMOGRAPHY; APICAL VERTEBRA; LUMBAR SPINE; CT SCANS; INSTRUMENTATION; FUSION; INTRAOBSERVER AB Background: As a result of the increased appreciation of the three-dimensional nature of scoliosis and modem spinal instrumentation's improved corrective capabilities, there has been renewed interest in the correction and measurement of vertebral rotation. Computed tomography (CT), the gold standard for accuracy, is limited in its clinical utility owing to cost, radiation exposure, and the effects of postural changes on scoliosis curves and vertebral rotation. Consequently, the Perdriolle and Nash-Moe techniques remain the standard measurements for providing a reasonable estimate of pre- and postoperative vertebral rotation because of their simplicity. However, these techniques have considerable interobserver variability, and pedicle screw instrumentation obscures the landmarks necessary for utilizing these techniques for postoperative vertebral rotation assessment. The purpose of the present study was to assess the utility of alternate radiographic measures to assess vertebral rotation and thoracic torsion when compared with conventional measures on preand postoperative radiographs and CT evaluation. Methods: We reviewed the preoperative, immediate postoperative, and final follow-up radiographs, as well as the pre- and postoperative CT scans, of 19 patients (average age 15 years, 6 months) with Lenke 1 curves (average 55 degrees, range 47-66 degrees), all treated with anterior spinal fusion. Coronal and sagittal Cobb angles as well as vertebral rotation (Perdriolle and Nash-Moe) at the superior uninstrumented, superior instrumented, apical, inferior instrumented, and inferior uninstrumented vertebrae were measured on all films, and vertebral rotation was assessed on the CT scans by a previously described method. Additionally, several measures of thoracic torsion (as a proxy for vertebral rotation and overall deformity improvement) were assessed. These included the rib-vertebral angle difference (RVAD), apical rib hump prominence (RH), apical vertebral body-rib ratio (AVB-R), and apical rib spread difference (ARSD). Results: The postoperative main thoracic curve averaged 26 degrees (range 16-39 degrees, 52% correction) and 29' (range 22-40 degrees, 47% correction) at final follow-up. For apical derotation, the postoperative CT improved from -11.5 degrees to - 6.6 degrees and correlated significantly with the Cobb main thoracic curves (42% correction, r = 0.48, P = 0.003). There was weakly positive, but statistically significant, correlation between the pre- and postoperative CT scans and the corresponding Perdriolle and Nash-Moe measures of segmental rotation (r = 0.32-0.40, all P < 0.0001). The RVAD demonstrated poor correlation with the main thoracic curve values and correction, Perdriolle rotation and correction, and CT rotation and correction (r= -0.22-0.37,all P > 0.20). The apical RH demonstrated good correlation with the main thoracic curve (r = 0.65, P < 0.0001), apical Perdriolle rotation (r = 0.57, P < 0.0001), and CT apical rotation (r = 0.53, P = 0.002). We also found moderate correlation between the AVB-R and the main thoracic Cobb, apical Perdriolle, and CT (r = 0.57, 0.59, and 0.49, respectively; all P < 0.005). Similar relationships were found with the ARSD (r = 0.51, 0.47, and 0.43, respectively; all P < 0.02). Conclusions: The RH, AVB-R, and the ARSD measures of thoracic torsion-demonstrated moderate to good overall correlation with the main thoracic curve Cobb angles, apical Perdriolle rotation, and apical CT rotation. These should be useful as clinical measures for assessing three-dimensional deformity correction on plane radiographs, especially for the intraoperative evaluation of vertebral derotation and thoracic symmetry restoration. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. St Louis Shriners Hosp Children, St Louis, MO USA. Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA. RP Kuklo, TR (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave NW,Bldg 2,5A, Washington, DC 20307 USA. EM Timothy.Kuklo@na.amedd.army.mil NR 62 TC 61 Z9 68 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1536-0652 J9 J SPINAL DISORD TECH JI J. Spinal Disord. Tech. PD APR PY 2005 VL 18 IS 2 BP 139 EP 147 DI 10.1097/01.bsd.0000159033.89623.bc PG 9 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 914CJ UT WOS:000228202000005 PM 15800431 ER PT J AU Kuklo, TR Potter, BK O'Brien, MF Schroeder, TM Lenke, LG Polly, DW AF Kuklo, TR Potter, BK O'Brien, MF Schroeder, TM Lenke, LG Polly, DW CA Spinal Deformity Study Grp TI Reliability analysis for digital adolescent idiopathic scoliosis measurements SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES LA English DT Article DE adolescent idiopathic scoliosis; radiographic parameter; digital measurement; intraobserver reliability; interobserver reliability ID INTEROBSERVER RELIABILITY; TECHNIQUE VARIABILITY; LUMBAR LORDOSIS; AXIAL ROTATION; INTRAOBSERVER; RADIOGRAPHS; CLASSIFICATION; PARAMETERS; AGREEMENT; KYPHOSIS AB Objective: Analysis of adolescent idiopathic scoliosis (AIS) requires a thorough clinical and radiographic evaluation to completely assess the three-dimensional deformity. Recently, these radiographic parameters have been analyzed for reliability and reproducibility following manual measurements; however, most of these parameters have not been analyzed with regard to digital measurements. The purpose of this study is to determine the intra- and interobserver reliability of common scoliosis radiographic parameters using a digital software measurement program. Methods: Thirty sets of preoperative (posteroanterior [PA], lateral, and side-bending [SB]) and postoperative (PA and lateral) radiographs were analyzed by three independent observers on two separate occasions using a software measurement program (PhDx, Albuquerque, NM). Coronal measures included main thoracic (MT) and thoracolumbar-lumbar (TL/L) Cobb, SB MT Cobb, MT and TL/L apical vertical translation (AVT), C7 to center sacral vertical line (CSVL), T1 tilt, LIV tilt, disk below lowest instrumented vertebra (LIV), coronal balance, and Risser, whereas sagittal measures included T2-T5, T5-TI2, T2-TI2, T10-L2, T12-S1, and sagittal balance. Analysis of variance for repeated measures or Cohen threeway kappa correlation coefficient analysis was performed as appropriate to calculate the intra- and interobserver reliability for each parameter. Results: The majority of the radiographic parameters assessed demonstrated good or excellent intra- and interobserver reliability. The relationship of the LIV to the CSVL (intraobserver kappa(a) = 0.480.78, fair to excellent; interobserver kappa(a) 0.34-0.41, fair to poor), interobserver measurement of AVT (p = 0.49-0.73, low to good), Risser grade (intraobserver p = 0.41-0.97, low to excellent; interobserver p = 0.60-0.70, fair to good), intraobserver measurement of the angulation of the disk inferior to the LIV (p = 0.53-0.88, fair to good), apical Nash-Moe vertebral rotation (intraobserver p = 0.500.85, fair to good; interobserver p = 0.53-0.59, fair), and especially regional thoracic kyphosis from T2 to T5 (intraobserver p = 0.220.65, poor to fair; interobserver p = 0.33-0.47, low) demonstrated lesser reliability. In general, preoperative measures demonstrated greater reliability than postoperative measures, and coronal angular measures were more reliable than sagittal measures. Conclusions: Most common radiographic parameters for AIS assessment demonstrated good or excellent reliability for digital measurement and can be recommended for routine clinical and academic use. Preoperative assessments and coronal measures may be more reliable than postoperative and sagittal measurements. The reliability of digital measurements will be increasingly important as digital radiographic viewing becomes commonplace. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Miami Childrens Hosp, Dept Orthopaed Surg, Miami, FL USA. St Louis Shriners Hosp Children, Dept Spinal Surg, St Louis, MO USA. Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA. Univ Minnesota, Dept Orthopaed Surg, Spine Serv, Minneapolis, MN 55455 USA. RP Kuklo, TR (reprint author), 15619 Thistlebridge Dr, Rockville, MD 20853 USA. EM Timothy.Kuklo@na.amedd.army.mil NR 32 TC 40 Z9 43 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1536-0652 J9 J SPINAL DISORD TECH JI J. Spinal Disord. Tech. PD APR PY 2005 VL 18 IS 2 BP 152 EP 159 DI 10.1097/01.bsd.0000148094.75219.b0 PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 914CJ UT WOS:000228202000007 PM 15800433 ER PT J AU Fasanella, EL Jackson, KE Sparks, CE Sareen, AK AF Fasanella, EL Jackson, KE Sparks, CE Sareen, AK TI Water impact test and simulation of a composite energy absorbing fuselage section SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 59th Annual Forum of the American-Helicopter-Society CY MAY 06-08, 2003 CL Phoenix, AZ SP Amer Helicopter Soc AB A 25-ft/s vertical drop test of a composite fuselage section was conducted onto water. The purpose of the test was to obtain experimental data characterizing the structural response of the fuselage section during water impact for comparison with two previous drop tests that were performed onto a rigid surface and soft soil. For the drop test, the fuselage section was configured with ten 100 lb. lead masses, five per side, that were attached to seat rails mounted to the floor. The fuselage section was raised to a height of 10 ft. and dropped vertically into a 15 ft. diameter pool filled to a depth of 3.5 ft. with water. Approximately 70 channels of data were collected during the drop test at a 10 kHz sampling rate. The test data were used to validate crash simulations of the water impact that were developed using the nonlinear, explicit transient dynamic codes, MSC.Dytran and LS-DYNA. The fuselage structure was modeled using shell and solid elements with a Lagrangian mesh, and the water was modeled with both Eulerian and Lagrangian techniques. The fluid-structure interactions were executed using the "fast" general coupling in NISC.Dytran and the Arbitrary Lagrange-Euler (ALE) coupling in LS-DYNA. Additionally, the smooth particle hydrodynamics (SPH) meshless Lagrangian technique was used. in LS-DYNA to represent the fluid. The simulation results were correlated with the test data to validate the modeling approach. Additional simulation studies were performed to determine how changes in mesh density, mesh uniformity, fluid viscosity, and failure strain influence the test-analysis correlation. C1 USA, Res Lab, Vehicle Technol Directorate, Hampton, VA USA. Bell Helicopter Textron Inc, Ft Worth, TX USA. RP Fasanella, EL (reprint author), USA, Res Lab, Vehicle Technol Directorate, Hampton, VA USA. NR 20 TC 11 Z9 12 U1 0 U2 7 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2005 VL 50 IS 2 BP 150 EP 164 PG 15 WC Engineering, Aerospace SC Engineering GA 928CW UT WOS:000229249700003 ER PT J AU Kufeld, RM Bousman, WG AF Kufeld, RM Bousman, WG TI Technical note - UH-60A airloads program azimuth reference correction SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID DYNAMIC STALL; FLIGHT AB Recent investigation of airloads data from the Army/NASA UH-60A Airloads Program has revealed an important error in the azimuthal reference used for comparison with rotorcraft analyses. A 7 degrees difference exists between flight test and analysis reference systems because of the offset of the elastomeric bearing from the hub axis. Most previously published data applied this 7 degrees shift in the wrong direction. Correction to published data, therefore, requires a 14 degrees shift to the left for azimuthally referenced data. The correction of the reference error has significantly improved correlation of comprehensive and especially coupled CFD analyses with the UH-60A Airloads Program data. Most publications prior to January 2005 utilize data with the incorrect azimuth reference. A list of affected Army/NASA publications is included in this paper. C1 NASA, Ames Res Ctr, Flight Vehicle Res & Technol Div, Moffett Field, CA 94035 USA. USA, Res Dev & Engn Command, Aeroflightdynam Directorate, Moffett Field, CA USA. RP Kufeld, RM (reprint author), NASA, Ames Res Ctr, Flight Vehicle Res & Technol Div, Moffett Field, CA 94035 USA. NR 18 TC 14 Z9 14 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2005 VL 50 IS 2 BP 211 EP 213 PG 3 WC Engineering, Aerospace SC Engineering GA 928CW UT WOS:000229249700008 ER PT J AU Cooke, WH Convertino, VA AF Cooke, WH Convertino, VA TI Heart rate variability and spontaneous baroreflex sequences: Implications for autonomic monitoring during hemorrhage SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE arterial pressure oscillations; autonomic; power spectral analysis; blood pressure control; lower body negative pressure; hemorrhagic shock ID SPECTRAL-ANALYSIS; BLOOD-VOLUME; BARORECEPTOR REFLEX; CONSCIOUS RABBITS; RESPONSES; MODULATION; PRESSURE; HUMANS; INJURY; DEATH AB Background. Noninvasive procedures for predicting progression to hemodynamic instability during induced central hypovolemia in humans were evaluated. The purpose of this study was twofold: (1) to track changes in autonomic function induced by a model of hemorrhage, and (2) to determine whether measures of autonomic function are reliable without strict control of breathing. Methods. Electrocardiogram, respiratory frequency, and arterial pressure during progressive lower body negative pressure were recorded for 10 subjects, and for a separate sample of 20 subjects during 5-minute periods of spontaneous breathing or controlled-frequency breathing at 15 breaths per minute.. Heart rate variability was calculated in both time and frequency domains. Up and down baroreflex sequences were calculated with linear regression analysis between sequential changes in systolic pressures and accompanying parallel changes in R-R intervals. Results. Heart rate variability (r(2) = 0.92) and up (r(2) = 0.90) and down (r(2) = 0.96) sequences changed in direct inverse relation to decreased central volume as produced by progressive increases in lower body negative pressure, whereas mean arterial pressures remained constant (r(2) = 0.26). Neither heart rate variability nor up and down baroreflex sequences were affected by the mode of breathing. Conclusions. Analysis of heart rate variability and baroreflex sequences in hemorrhaging patients may provide advance recognition of those at risk for progression to shock. In conjunction with more traditional modes of assessing volume status, tracking early changes in autonomic function may improve resuscitation efforts for the hemodynamic compromised patient. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cooke, WH (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave Blvd 3611, Ft Sam Houston, TX 78234 USA. EM william.cooke@amedd.army.mil FU NHLBI NIH HHS [HL-67787-01] NR 32 TC 36 Z9 36 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2005 VL 58 IS 4 BP 798 EP 805 DI 10.1097/01.TA.0000151345.16338.FD PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 919VS UT WOS:000228646300036 PM 15824659 ER PT J AU Iyer, K AF Iyer, K TI Analysis of the size effect in partial-slip contact fatigue SO JOURNAL OF TRIBOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID CYCLIC STRESS AMPLITUDES; FRETTING FATIGUE; SEMI-WIDTH; PRESSURE; LIFE AB A size effect has been observed in cylinder-on-flat partial slip contact fatigue experiments (Hills et al., 1988 and 1990). The size effect in this case is defined as a discontinuous drop in the fatigue life beyond some critical value of the width of the contact region. New analysis that directly accounts for the finite substrate thickness used in the original experiments shows that both the maximum local bulk stress and maximun local bulk cyclic stress range increased systematically with contact width in the original cylinder-on-flat experiments, rather than remaining approximately constant as intended in the original experimental design. C1 USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. RP Iyer, K (reprint author), USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. EM kiyer@arl.army.mil RI Iyer, Kaushik/H-1411-2016 NR 8 TC 2 Z9 2 U1 0 U2 3 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4787 J9 J TRIBOL-T ASME JI J. Tribol.-Trans. ASME PD APR PY 2005 VL 127 IS 2 BP 443 EP 446 DI 10.1115/1.1739411 PG 4 WC Engineering, Mechanical SC Engineering GA 922GD UT WOS:000228823700022 ER PT J AU McLeod, DG See, WA Klimberg, I Gleason, D Chodak, GW Morris, T Armstrong, J AF McLeod, DG See, WA Klimberg, I Gleason, D Chodak, GW Morris, T Armstrong, J TI The bicalutamide Early Prostate Cancer program: Findings of the north American trial at median 5.7 years' follow-up SO JOURNAL OF UROLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Urological-Association CY MAY 21-26, 2005 CL San Antonio, TX SP Amer Urol Assoc C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Med Coll Wisconsin, Milwaukee, WI 53226 USA. Urol Ctr Florida, Ocala, FL USA. Adv Clin Therapeut Inc, Tucson, AZ USA. Prostate & Urol Hlth Ctr, Chicago, IL USA. AstraZeneca, Macclesfield, Cheshire, England. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD APR PY 2005 VL 173 IS 4 SU S MA 674 BP 184 EP 184 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 907AU UT WOS:000227687901109 ER PT J AU Chodak, GW Iversen, P McLeod, DG See, WA Wirth, MP Morris, C Armstrong, J AF Chodak, GW Iversen, P McLeod, DG See, WA Wirth, MP Morris, C Armstrong, J TI Prostate-specific antigen levels as a predictor of positive bone scans during follow-up after standard care for prostate cancer: data from the bicalutamide early prostate cancer program SO JOURNAL OF UROLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Urological-Association CY MAY 21-26, 2005 CL San Antonio, TX SP Amer Urol Assoc C1 Prostate & Urol Hlth Ctr, Chicago, IL USA. Dept Urol, Copenhagen, Denmark. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Med Coll Wisconsin, Milwaukee, WI 53226 USA. Tech Univ Dresden, D-8027 Dresden, Germany. AstraZeneca, Macclesfield, Cheshire, England. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD APR PY 2005 VL 173 IS 4 SU S MA 1013 BP 275 EP 275 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 907AU UT WOS:000227687901448 ER PT J AU Fox, CJ Gillespie, DL O'Donnell, SD Rasmussen, TE Goff, JM Johnson, CA Galgon, RE Sarac, TP Rich, NM AF Fox, CJ Gillespie, DL O'Donnell, SD Rasmussen, TE Goff, JM Johnson, CA Galgon, RE Sarac, TP Rich, NM TI Contemporary management of wartime vascular trauma SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT Joint Annual Meeting of the Society-for-Vascular-Surgery/American-Association-for-Vascular-Surgery CY JUN 03-06, 2004 CL Anaheim, CA SP Soc Vasc Surg, Amer Assoc Vasc Surg ID INJURY MANAGEMENT; WOUNDS; VIETNAM; COMPLICATIONS; BATTLEFIELD; CASUALTIES; ARTERIES; LESSONS; REPAIR AB Objective: The treatment of wartime injuries has led to advances in the diagnosis and treatment of vascular trauma. Recent experience has stimulated a reappraisal of the management of such injuries, specifically assessing the effect of explosive devices on injury patterns and treatment strategies. The objective of this report is to provide a single-institution analysis of injury patterns and management strategies in the care of modern wartime vascular injuries. Methods: From December 2001 through March 2004, all wartime evacuees evaluated at a single institution were prospectively entered into a database and retrospectively reviewed. Data collected included site, type, and mechanism of vascular injury; associated trauma; type of vascular repair; initial outcome; occult injury; amputation rate; and complication. Liberal application of arteriography was used to assess these injuries. The results of that diagnostic and therapeutic approach, particularly as it related to the care of the blast-injured patient, are reviewed. Results: Of 3057 soldiers evacuated for medical evaluation, 1524 (50%) sustained battle injuries. Known or suspected vascular injuries occurred in 107 (7%) patients, and these patients comprised the study group. Sixty-eight (64%) patients were wounded by explosive devices, 27 (25%) were wounded by gunshots, and 12 (11%) experienced blunt traumatic injury. The majority of injuries (59/66 (88%)) occurred in the extremities. Nearly half (48/107) of the patients underwent vascular repair in a forward hospital in Iraq or Afghanistan. Twenty-eight (26%) required additional operative intervention on arrival in the United States. Vascular injuries were associated with bony fracture in 37% of soldiers. Twenty-one of the 107 had a primary amputation performed before evacuation. Amputation after vascular repair occurred in 8 patients. Of those, 5 had mangled extremities associated with contaminated wounds and infected grafts. Sixty-seven (63%) patients underwent diagnostic angiography. The most common indication was mechanism of injury (42%), followed by abnormal examination (33%), operative planning (18%), or evaluation of a repair (7%). Conclusions: This interim report represents the largest analysis of US military vascular injuries in more than 30 years. Wounding patterns reflect past experience with a high percentage of extremity injuries. Management of arterial repair with autologous vein graft remains the treatment of choice. Repairs in contaminated wound beds should be avoided. An increase in injuries from improvised explosive devices in modern conflict warrants the more liberal application of contrast arteriography. Endovascular techniques have advanced the contemporary management and proved valuable in the treatment of select wartime vascular injuries. C1 Walter Reed Army Med Ctr, Dept Surg, Peripheral Vasc Surg Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Fox, CJ (reprint author), Walter Reed Army Med Ctr, Dept Surg, Peripheral Vasc Surg Serv, Bldg 2,Ward 64,6900 Georgia Ave, Washington, DC 20307 USA. EM Charles.Fox@na.amedd.army.mil OI Gillespie, David/0000-0002-4378-9465 NR 21 TC 92 Z9 104 U1 1 U2 2 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD APR PY 2005 VL 41 IS 4 BP 638 EP 643 DI 10.1016/j.jvs.2005.01.010 PG 6 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 920PI UT WOS:000228702200013 PM 15874928 ER PT J AU Gamble, S AF Gamble, S TI A bridge too far SO LAB ANIMAL LA English DT Editorial Material C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Gamble, S (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA SN 0093-7355 J9 LAB ANIMAL JI Lab Anim. PD APR PY 2005 VL 34 IS 4 BP 25 EP 25 DI 10.1038/laban0405-25 PG 1 WC Veterinary Sciences SC Veterinary Sciences GA 914DB UT WOS:000228204000008 PM 15806086 ER PT J AU D'Aguanno, G Mattiucci, N Scalora, M Bloemer, MJ AF D'Aguanno, G Mattiucci, N Scalora, M Bloemer, MJ TI Transmission properties and field localization in a negative index Fabry-Perot etalon SO LASER PHYSICS LA English DT Article; Proceedings Paper CT 13th International Laser Physics Workshop CY JUL 12-16, 2004 CL Trieste, ITALY ID REFRACTION AB We study a single slab of negative-index material of finite thickness at normal and angular incidence. The slab is characterized by a band gap in the transmission spectrum with superluminal group velocities and small group velocities at the band edges. The spectral width of the gap is proportional to the difference between the electric and magnetic plasma frequencies. The spectral position and the spectral width of the gap are independent of the length of the slab at normal incidence, while the band gap increases its width at angular incidence for a fixed length. Moreover, the structure admits the formation of highly localized electromagnetic modes that may be used to enhance nonlinear optical phenomena. C1 Time Domain Corp, Huntsville, AL 35806 USA. USA, Missile Command, Weapons Sci Directorate, Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. Univ RomaTre, Dipartimento Fis E Amaldi, I-00146 Rome, Italy. RP D'Aguanno, G (reprint author), Time Domain Corp, Cummings Res Pk,7057 Old Madison Pike, Huntsville, AL 35806 USA. EM giuseppe.daguanno@timedomain.com OI D'Aguanno, Giuseppe/0000-0002-7132-0103 NR 9 TC 12 Z9 12 U1 0 U2 0 PU INTERPERIODICA PI BIRMINGHAM PA PO BOX 1831, BIRMINGHAM, AL 35201-1831 USA SN 1054-660X J9 LASER PHYS JI Laser Phys. PD APR PY 2005 VL 15 IS 4 BP 590 EP 593 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA 921SY UT WOS:000228786400018 ER PT J AU Burgess, EB AF Burgess, EB TI D-Days in the Pacific. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2005 VL 130 IS 6 BP 110 EP 110 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 913CK UT WOS:000228127800191 ER PT J AU Kan, RK Pleva, CM Hamilton, TA Petrali, JP AF Kan, RK Pleva, CM Hamilton, TA Petrali, JP TI Immunolocalization of MAP-2 in routinely formalin-fixed, paraffin-embedded guinea pig brain sections using microwave irradiation: A comparison of different combinations of antibody clones and antigen retrieval buffer solutions SO MICROSCOPY AND MICROANALYSIS LA English DT Article DE antigen retrieval; immunohistochemistry; cytoskeletal protein; formaldehyde; fixation; pretreatment; nerve agent; soman ID MICROTUBULE-ASSOCIATED PROTEIN-2; TISSUES; IMMUNOHISTOCHEMISTRY; INJURY; PH AB The present study was designed to evaluate the efficacy of different microwave pretreatment methods to retrieve microtubule-associated protein 2 (MAP-2) immunoreactivity in formalin-fixed, paraffin-embedded guinea pig brain sections. Brain sections, microwave pretreated in boiling sodium citrate, citric acid, Tris hydrochloride, and EDTA buffers of pH 4, 6, and 8, were labeled with four different clones of MAP-2 monoclonal antibodies. No MAP-2 immunoreactivity was observed in control sections processed without microwave pretreatment. Optimal MAP-2 immunoreactivity was observed only when MAP-2 antibody clone AP18 was used in conjunction with citric acid buffer of pH 6.0. Using this combination, brain sections from nerve agent soman-exposed guinea pigs were found to exhibit marked reduction in MAP-2 immunostaining in the hippocampus. These observations suggest that the clone of the antibody in addition to the type and pH of antigen retrieval (AR) solution are important variables to be considered for establishing an optimal AR technique. When studying counterpart antigens of species other than that to which the antibodies were originally raised, different antibody clones must be tested in combination with different microwave-assisted AR (MAR) methods. This MAR method makes it possible to conduct retrospective studies on archival guinea pig brain paraffin blocks to evaluate changes in neuronal MAP-2 expression as a consequence of chemical warfare nerve agent toxicity. C1 USA, Med Res Inst Chem Def, Comparat Pathol Branch, Div Comparat Med, Aberdeen Proving Ground, MD 21010 USA. RP Kan, RK (reprint author), USA, Med Res Inst Chem Def, Comparat Pathol Branch, Div Comparat Med, Aberdeen Proving Ground, MD 21010 USA. EM Robert.Kan@amedd.army.mil NR 17 TC 5 Z9 5 U1 2 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA SN 1431-9276 J9 MICROSC MICROANAL JI Microsc. microanal. PD APR PY 2005 VL 11 IS 2 BP 175 EP 180 DI 10.1017/S1431927605050191 PG 6 WC Materials Science, Multidisciplinary; Microscopy SC Materials Science; Microscopy GA 912GZ UT WOS:000228066900010 PM 15817147 ER PT J AU Wilson, RL Truesdell, AG Rinaldo, JE AF Wilson, RL Truesdell, AG Rinaldo, JE TI Why the military needs humanitarian medicine specialists SO MILITARY MEDICINE LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Wilson, RL (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2005 VL 170 IS 4 BP XI EP XIII PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 019JK UT WOS:000235831200001 PM 15916289 ER PT J AU Cho, JM Jatoi, I Alarcon, AS Morton, TM King, BT Hermann, JM AF Cho, JM Jatoi, I Alarcon, AS Morton, TM King, BT Hermann, JM TI Operation Iraqi freedom: Surgical experience of the 212th Mobile Army Surgical Hospital SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 89th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 19-23, 2003 CL CHICAGO, IL SP Amer Coll Surg ID DESERT-STORM; WAR; LESSONS; TRAUMA; HOSPITALS; INJURIES; SUPPORT; SHIELD AB Seven hundred one patients were treated at and 394 were admitted to the 212th Mobile Army Surgical Hospital in Central Iraq during the combat phase of Operation Iraqi Freedom. Ninety of those patients underwent 100 operations, with 187 procedures in 19 days. At the peak of hostilities, 48 patients were admitted, 15 operations were performed, and 56 patients were medically evacuated during different 24-hour periods. Thirty-three patients required the surgical expertise of a general or thoracic surgeon. Although 82% of injuries and 70% of the procedures were orthopedic in nature, orthopedic operating room utilization was only 60% of total operating room time (156 hours). The general and thoracic injuries were labor-intensive, frequently requiring two surgeons. Although orthopedic injury remains the predominant reason for surgical intervention on the battlefield, there remains a need to forward-deploy general and thoracic surgeons, because of the presence and complexity of nonorthopedic trauma. C1 Mobile Army Surg Hosp 212th, Dept Surg, APO, AE 09059 USA. RP Cho, JM (reprint author), Womack Army Med Ctr, Clin Serv, Ft Bragg, NC 28310 USA. NR 18 TC 22 Z9 22 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2005 VL 170 IS 4 BP 268 EP 272 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 019JK UT WOS:000235831200003 PM 15916291 ER PT J AU Ridderhoff, K Remund, D AF Ridderhoff, K Remund, D TI Department of Defense pharmacy benefit management program SO MILITARY MEDICINE LA English DT Article ID SECTOR AB Prescription drug prices are frequently both politically and personally salient issues. The Department of Defense (DoD) offers a robust prescription benefit to 8.8 million beneficiaries. This benefit has evolved to meet changes in technology and patient requirements. The PharmacoEconomic Center (PEC) was established as the first pharmacy benefit manager entity in 1992, primarily in response to rapidly rising DoD pharmacy program expenditures. In its short history, the PEC has dramatically improved patient safety and decreased costs. To accelerate the efficiency and effectiveness the enterprise-wide pharmacy benefit manager has already achieved, DoD should increase the funding, staff, and authority of the PEC. C1 Baylor Univ, USA, Grad Program Hlth Care Adm, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. RP Ridderhoff, K (reprint author), Baylor Univ, USA, Grad Program Hlth Care Adm, Med Dept Ctr & Sch, 3151 Scott Rd, Ft Sam Houston, TX 78234 USA. NR 22 TC 1 Z9 1 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2005 VL 170 IS 4 BP 302 EP 304 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 019JK UT WOS:000235831200011 PM 15916299 ER PT J AU Mangelsdorff, AD Finstuen, K Larsen, SD Weinberg, EJ AF Mangelsdorff, AD Finstuen, K Larsen, SD Weinberg, EJ TI Patient satisfaction in military medicine: Model refinement and assessment of Department of Defense effects SO MILITARY MEDICINE LA English DT Article AB A sample of 154,893 patient responses from the Customer Satisfaction Survey database was drawn for 1999 to 2000. Average patient satisfaction levels consistently appeared to be high (between 6, very satisfied, and 7, completely satisfied, on the 7-point rating scale). Hierarchical regression results essentially replicated all three major constructs of an earlier theoretical attitude model. Refinements included adjustment and addition of categorical age and military beneficiary status for individual patient variables, addition of two beliefs about the care itself, substitution of waiting time variables, and addition of reason for visit situation variables. Hypothesis test results indicated that patient satisfaction constructs were homogeneous across the uniformed services for patients from all service branches, both enrolled and not enrolled within TRICARE regions, and among branch of service medical center, hospital, and clinic facilities. The final attitude model coefficient of multiple determinations obtained was R-2 = 0.701 [F(25,154,867) = 14,539.33, p < 0.0001]. C1 Baylor Univ, USA, Program Hlth Care Adm, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. RP Mangelsdorff, AD (reprint author), Baylor Univ, USA, Program Hlth Care Adm, Med Dept Ctr & Sch, 3151 Scott Rd, Ft Sam Houston, TX 78234 USA. NR 10 TC 6 Z9 6 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2005 VL 170 IS 4 BP 309 EP 314 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 019JK UT WOS:000235831200013 PM 15916301 ER PT J AU Burnett, JC Henchal, EA Schmaljohn, AL Bavari, S AF Burnett, JC Henchal, EA Schmaljohn, AL Bavari, S TI The evolving field of biodefence: Therapeutic developments and diagnostics SO NATURE REVIEWS DRUG DISCOVERY LA English DT Review ID ANTHRAX LETHAL FACTOR; RICIN A-CHAIN; BOTULINUM NEUROTOXIN-B; PUBLIC-HEALTH MANAGEMENT; EBOLA-VIRUS GLYCOPROTEIN; T-CELL ACTIVATION; STAPHYLOCOCCAL-ENTEROTOXIN-B; SMALL-MOLECULE INHIBITORS; N-GLYCOSIDASE ACTIVITY; ACTIVITY IN-VITRO AB The threat of bioterrorism and the potential use of biological weapons against both military and civilian populations has become a major concern for governments around the world. For example, in 2001 anthrax-tainted letters resulted in several deaths, caused widespread public panic and exerted a heavy economic toll. If such a small-scale act of bioterrorism could have such a huge impact, then the effects of a large-scale attack would be catastrophic. This review covers recent progress in developing therapeutic countermeasures against, and diagnostics for, such agents. C1 NCI, Dev Therapeut Program, Based Drug Discovery Grp, SAIC, Frederick, MD 21702 USA. USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Bavari, S (reprint author), NCI, Dev Therapeut Program, Based Drug Discovery Grp, SAIC, Frederick, MD 21702 USA. EM sina.bavari@amedd.army NR 204 TC 100 Z9 101 U1 4 U2 17 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1474-1776 J9 NAT REV DRUG DISCOV JI Nat. Rev. Drug Discov. PD APR PY 2005 VL 4 IS 4 BP 281 EP 297 DI 10.1038/nrd1694 PG 17 WC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy SC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy GA 912PV UT WOS:000228092600016 PM 15803193 ER PT J AU Janiec, DJ Jacobson, ER Freeth, A Spaulding, L Blaszyk, H AF Janiec, DJ Jacobson, ER Freeth, A Spaulding, L Blaszyk, H TI Histologic variation of grade and stage of nonalcoholic fatty liver disease in liver biopsies SO OBESITY SURGERY LA English DT Article DE non-alcoholic fatty liver disease (NAFLD); Roux-en-Y gastric bypass; morbid obesity; liver biopsy; grade; stage; sampling error ID STEATOHEPATITIS; HEPATITIS; SIZE AB Background: Sampling error regarding disease grade and stage has been ascribed to needle liver biopsies in patients with chronic liver disease. Although several studies evaluating sampling error in liver biopsies exist, none have investigated this phenomenon in patients with non-alcoholic fatty liver disease (NAFLD). This study alms to determine the rate and extent of sampling error in liver biopsies obtained from patients undergoing Roux-en-Y gastric bypass (RYGBP) surgery for morbid obesity. Methods: 10 morbidly obese patients underwent simultaneous liver biopsies from the right and left hepatic lobes during an open examination preceding the RYGBP procedure. The biopsies were subsequently randomly evaluated and then blindly re-evaluated by a liver pathologist. Degrees of inflammatory activity and fibrosis were determined and scored for each sample using a semi-quantitative system with 3 grades and 4 stages. Results: No grading differences were observed, and 3 patients (30%) had a difference of at least 1 stage between the right and left lobes. One patient had a 2-stage difference in paired samples, with significantly different biopsy sizes and number of portal tracts. Blinded histologic re-evaluation did not result in grading or staging scores that differed from the original evaluation. Conclusions: Liver biopsy samples taken from the right and left hepatic lobes showed similar grades of disease activity, but differed in histopathologic staging in 30% of the NAFLD patients. Obtaining an adequately sized biopsy (> 1.0 cm in length with > 10 portal tracts) greatly reduces sampling error. C1 Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA. Univ Vermont, Coll Med, Dept Endocrinol, Burlington, VT 05405 USA. Univ Vermont, Coll Med, Dept Surg, Burlington, VT 05405 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Blaszyk, H (reprint author), Univ Vermont, Coll Med, Dept Pathol, 89 Beaumont Ave, Burlington, VT 05405 USA. EM hagen.blaszyk@vtmednet.org NR 9 TC 58 Z9 60 U1 0 U2 1 PU F D-COMMUNICATIONS INC PI TORONTO PA 3100 BAYVIEW AVE, UNIT 4, TORONTO, ONTARIO M2N 5L3, CANADA SN 0960-8923 J9 OBES SURG JI Obes. Surg. PD APR PY 2005 VL 15 IS 4 BP 497 EP 501 DI 10.1381/0960892053723268 PG 5 WC Surgery SC Surgery GA 923LI UT WOS:000228911000007 PM 15946428 ER PT J AU Stojadinovic, A Margolin, M Singh, M Akin, M Pulliam, R Platt, L AF Stojadinovic, A Margolin, M Singh, M Akin, M Pulliam, R Platt, L TI A novel technique for primary breast cancer screening in young women SO OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 53rd Annual Clinical Meeting of the American-College-of-Obstetricians-and-Gynecologists CY MAY 07-11, 2005 CL San Francisco, CA SP Amer Coll Obstetricans & Gynecol, Organon Pharmaceut US Inc, Novo Nordisk Pharmaceut C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD APR PY 2005 VL 105 IS 4 SU S BP 4S EP 4S PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 912GP UT WOS:000228065900011 ER PT J AU Yauger, BJ Parker, MF Rodriguez, M AF Yauger, BJ Parker, MF Rodriguez, M TI Comparison of default in a military colposcopy clinic SO OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 53rd Annual Clinical Meeting of the American-College-of-Obstetricians-and-Gynecologists CY MAY 07-11, 2005 CL San Francisco, CA SP Amer Coll Obstetricans & Gynecol, Organon Pharmaceut US Inc, Novo Nordisk Pharmaceut C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD APR PY 2005 VL 105 IS 4 SU S BP 44S EP 44S PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 912GP UT WOS:000228065900102 ER PT J AU Snook, JH Samuelson, LA Kumar, J Kim, YG Whitten, JE AF Snook, JH Samuelson, LA Kumar, J Kim, YG Whitten, JE TI Ultraviolet photoelectron spectroscopy of nanocrystalline TiO2 films sensitized with (2,2 '-bipyridyl)ruthenium(II) dyes for photovoltaic applications SO ORGANIC ELECTRONICS LA English DT Article DE electronic structure; photoemission; photovoltaics ID (2,2'-BIPYRIDYL-4,4'-DICARBOXYLIC ACID)RUTHENIUM(II) COMPLEXES; SOLAR-CELLS; TITANIUM-DIOXIDE; SURFACE; LIGHT; INTERFACE; ABSORPTION; ELECTRODES; CONVERSION; POLYMERS AB Ultraviolet photoelectron spectroscopy (UPS) has been used to determine the highest occupied molecular orbital (HOMO) energy levels of a series of related 2,2'-bipyridyl-substituted ruthenium dyes utilized in the fabrication of photovoltaic devices. UPS analysis of nanocrystalline TiO2 thin films sensitized with a monolayer of cis-dithiocyanato-N,N-bis-(2,2'-bipyridyl-4,4'-dicarboxylic acid)-ruthenium(II), commonly referred to as "N3", indicates that the HOMO is located 5.47 eV below the vacuum level. Combination of the UPS results with measurement of the bandgap of the dye by UV-Vis absorbance spectroscopy yields an estimated lowest unoccupied molecular orbital (LUMO) energy of 3.93 eV below the vacuum level. Similar analyses have been performed for the related dyes, (5-amino-1,10-phenanthroline)bis-(2,2'-bipyridyl-4,4'-dicarboxylic acid)-ruthenium(II), (1,10-phenanthroline)bis-(2,2'-bipyridyl-4,4'-dicarboxylic acid)-ruthenium(II), and (5-amino-1,10-phenanthroline)bis-(2,2'-bipyridine)-ruthenium(II); giving values of 3.35, 3.08, and 3.43 eV, respectively, for the positions of the LUMOs below the vacuum level. These results indicate that the LUMO of N3 has better overlap with the conduction band of TiO2 located 3.70 eV below the vacuum level, and this may at least partially be responsible for its outstanding photovoltaic performance. (c) 2005 Elsevier B.V. All rights reserved. C1 Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA. USA, Res Dev & Engn Command, Natick Soldier Ctr, Natick, MA 01760 USA. RP Whitten, JE (reprint author), Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA. EM james_whitten@uml.edu NR 40 TC 17 Z9 17 U1 0 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1566-1199 J9 ORG ELECTRON JI Org. Electron. PD APR PY 2005 VL 6 IS 2 BP 55 EP 64 DI 10.1016/j.orgel.2005.03.001 PG 10 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 935XH UT WOS:000229816200001 ER PT J AU Lee, JW Weiner, RS Sailstad, JM Bowsher, RR Knuth, DW O'Brien, PJ Fourcroy, JL Dixit, R Pandite, L Pietrusko, RG Soares, HD Quarmby, V Vesterqvist, OL Potter, DM Witliff, JL Fritche, HA O'Leary, T Perlee, L Kadam, S Wagner, JA AF Lee, JW Weiner, RS Sailstad, JM Bowsher, RR Knuth, DW O'Brien, PJ Fourcroy, JL Dixit, R Pandite, L Pietrusko, RG Soares, HD Quarmby, V Vesterqvist, OL Potter, DM Witliff, JL Fritche, HA O'Leary, T Perlee, L Kadam, S Wagner, JA TI Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: A conference report SO PHARMACEUTICAL RESEARCH LA English DT Article DE biomarkers; nonclinical and clinical drug development; quantitative method development and validation ID ROLLING-CIRCLE AMPLIFICATION; SURROGATE END-POINTS; DIABETES-MELLITUS; MICROARRAYS; RECOMMENDATIONS; MACROMOLECULES; IMMUNOASSAYS; OPTIMIZATION; MARKERS; ASSAYS AB Biomarkers are increasingly used in drug development to aid scientific and clinical decisions regarding the progress of candidate and marketed therapeutics. Biomarkers can improve the understanding of diseases as well as therapeutic and off-target effects of drugs. Early implementation of biomarker strategies thus promises to reduce costs and time-to-market as drugs proceed through increasingly costly and complex clinical development programs. The 2003 American Association of Pharmaceutical Sciences/Clinical Ligand Assay Society Biomarkers Workshop (Salt Lake City, UT, USA, October 24-25, 2003) addressed key issues in biomarker research, with an emphasis on the validation and implementation of biochemical biomarker assays, covering from preclinical discovery of efficacy and toxicity biomarkers through clinical and postmarketing implementation. This summary report of the workshop focuses on the major issues discussed during presentations and open forums and noted consensus achieved among the participants on topics from nomenclature to best practices. For example, it was agreed that because reliable and accurate data provide the basis for sound decision making, biomarker assays must be validated in a manner that enables the creation of such data. The nature of biomarker measurements often precludes direct application of regulatory guidelines established for clinical diagnostics or drug bioanalysis, and future guidance on biomarker assay validation should therefore be adaptable enough that validation criteria do not stifle creative biomarker solutions. C1 MDS Pharma Serv, Lincoln, NE USA. Bristol Myers Squibb Co, Princeton, NJ USA. Trimeris Inc, Durham, NC USA. LINCO Diagnost Serv, St Charles, MO USA. Jasper Clin, Kalamazoo, MI USA. Eli Lilly & Co, Indianapolis, IN 46285 USA. Walter Reed Army Med Ctr, Bethesda, MD USA. Merck & Co Inc, W Point, PA USA. GlaxoSmithKline, Res Triangle Pk, NC USA. Millenium Pharmaceut, Cambridge, MA USA. Pfizer Global Res, Groton, CT USA. Genetech Inc, San Francisco, CA USA. Univ Louisville, Louisville, KY 40292 USA. Univ Texas, MD Anderson Hosp, Austin, TX 78712 USA. US FDA, Rockville, MD 20857 USA. Mol Staging Inc, New Haven, CT USA. RP Lee, JW (reprint author), MDS Pharma Serv, Lincoln, NE USA. EM jean.lee@mdsinc.com NR 37 TC 92 Z9 96 U1 0 U2 6 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0724-8741 J9 PHARM RES JI Pharm. Res. PD APR PY 2005 VL 22 IS 4 BP 499 EP 511 DI 10.1007/s11095-005-2484-z PG 13 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA 919TV UT WOS:000228641400021 PM 15846456 ER PT J AU Scremin, OU Shih, TM Huynh, L Roch, M Sun, W Chialvo, DR Jenden, DJ AF Scremin, OU Shih, TM Huynh, L Roch, M Sun, W Chialvo, DR Jenden, DJ TI Low-dose cholinesterase inhibitors do not induce delayed effects on cerebral blood flow and metabolism SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE nerve agents; sarin; pyridostigmine bromide; cerebral glucose utilization; cerebrovascular circulation; low dose cholinesterase toxicity ID PYRIDOSTIGMINE BROMIDE; GLUCOSE-UTILIZATION; NERVE AGENT; SOMAN; RATS; PHYSOSTIGMINE; CIRCULATION; PRESSURE; EXPOSURE; SARIN AB The acetylcholinesterase (ACK) inhibitors sarin and pyridostigmine bromide (PB) have been proposed as causes of neurobehavioral dysfunction in Persian Gulf War veterans. To test possible delayed effects of these agents, we exposed rats to low (subsymptomatic) levels of sarin (0.5 LD50 s.c. 3 times weekly) and/or PB (80 mg/L in drinking water) for 3 weeks. Controls received saline s.c. and tap water. At 2, 4 and 16 weeks after exposure, regional cerebral blood flow (rCBF) and glucose utilization (rCGU) were measured in conscious animals with the Iodo-C-14-antipyrine and C-14-2 deoxyglucose methods, respectively. Two weeks after exposure, PB+sarin caused significant rCBF elevations, but no changes in rCGU, in neocortex, with lesser effects on allocortex. Four weeks after exposure, the same general pattern was found with sarin. Only a few changes were found at 16 weeks post-treatment. The predominant effects of sarin or PB+sarin on rCBF at earlier times after treatment are consistent with the well known direct cerebral vascular effect of cholinergic agonists. The lack of changes in rCBF and rCGU observed at 16 weeks after treatment does not support the hypothesis that repeat exposure to low-dose cholinesterase inhibitors can generate permanent alterations in cerebral activity. (c) 2004 Elsevier Inc. All rights reserved. C1 VA GLA Healthcare Syst, Dept Res, Los Angeles, CA 90073 USA. USA, Med Res Inst Chem Def, Div Pharmacol, Aberdeen Proving Ground, MD 21010 USA. Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA. Univ Calif Los Angeles, David Geffen Sch Med, Dept Med & Mol Pharmacol, Los Angeles, CA 90095 USA. RP Scremin, OU (reprint author), VA GLA Healthcare Syst, Dept Res, 11301 Wilshire Blvd,Bldg 115,Rm 319, Los Angeles, CA 90073 USA. EM oscremin@ucla.edu RI Chialvo, Dante/A-4658-2009 OI Chialvo, Dante/0000-0002-1038-3637 NR 49 TC 2 Z9 3 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD APR PY 2005 VL 80 IS 4 BP 529 EP 540 DI 10.1016/j.pb.2004.12.013 PG 12 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA 920GT UT WOS:000228678100001 PM 15820522 ER PT J AU Wraback, M Shen, H Sampath, AV Collins, CJ Garrett, GA Sarney, WL AF Wraback, M Shen, H Sampath, AV Collins, CJ Garrett, GA Sarney, WL TI Time-resolved reflectivity studies of coherent longitudinal acoustic phonon pulses in bulk III-nitride semiconductors SO PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT International Workshop on Nitrides Semiconductors (IWN 2004) CY JUL 19-23, 2004 CL Pittsburgh, PA ID PIEZOELECTRIC FIELDS; QUANTUM-WELLS; SPECTROSCOPY; OSCILLATIONS; GENERATION; VELOCITY; GAN AB An interferometric technique employing femtosecond pump-probe reflectivity measurements has been used to study the direct generation, propagation, and detection of coherent longitudinal acoustic (LA) phonon pulses in bulk GaN and AlGaN thin films at frequencies in the 100 to 200 GHz range. Photoreflectance and resonant Raman studies suggest that the dominant mechanism in the generation of the LA phonon pulse is photoexcited carrier transport-induced screening of the near-surface electric field associated with residual strain in the incompletely relaxed GaN or AlGaN epilayers. This field screening component in the strain pulse generation can be as much as two orders of magnitude larger than the deformation potential component, in contrast to theoretical calculations for the multiple quantum well (MQW) case, for which the two components are of comparable magnitude. The technique has been used to directly measure the sound velocity in GaN and AlGaN of various Al contents. The results are in good agreement with those calculated from elastic moduli. (c) 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Wembeim. C1 USA, Res Lab, Sensors & Electron Devices Direct, AMSRL SE EM, Adelphi, MD 20783 USA. RP Wraback, M (reprint author), USA, Res Lab, Sensors & Electron Devices Direct, AMSRL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mwraback@arl.army.mil NR 14 TC 3 Z9 3 U1 0 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0031-8965 J9 PHYS STATUS SOLIDI A JI Phys. Status Solidi A-Appl. Mat. PD APR PY 2005 VL 202 IS 5 BP 790 EP 794 DI 10.1002/pssa.200461506 PG 5 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 920HE UT WOS:000228679200021 ER PT J AU Garrett, GA Shen, H Wraback, M Imer, B Haskell, B Speck, JS Keller, S Nakamura, S DenBaars, SP AF Garrett, GA Shen, H Wraback, M Imer, B Haskell, B Speck, JS Keller, S Nakamura, S DenBaars, SP TI Intensity dependent time-resolved photoluminescence studies of GaN/AlGaN multiple quantum wells of varying well width on laterally overgrown a-plane and planar c-plane GaN SO PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT International Workshop on Nitrides Semiconductors (IWN 2004) CY JUL 19-23, 2004 CL Pittsburgh, PA ID EPITAXIAL OVERGROWTH; EMISSION; NITRIDE AB GaN/AlGaN multiple quantum wells (MQWs) of varying well width grown on planar c-plane GaN and a-plane GaN templates fabricated by lateral epitaxial overgrowth (LEO) have been studied by subpicosecond photoluminescence (PL) downconversion and time-correlated single photon counting as a function of pump intensity. Although slower room temperature decays at higher carrier density are observed in both a-plane LEO and c-plane MQWs with 3 nm well width, this behavior is attributed to suppression of electric field-enhanced recombination through the barriers and interfaces at higher carrier density in the c-plane MQW, while in the a-plane LEO MQW the sublinear dependence of the PL signal at t = 0 on pump intensity implies that the radiative lifetime in this high quality sample increases due to a reduction in excitonic oscillator strength associated with phase space filling. The combination of more intense time-integrated PL spectra and shorter PL lifetimes with decreasing well width in the a-plane LEO MQWs for low pump intensity suggests that the radiative lifetime becomes shorter due to the accompanying increase in exciton binding energy and oscillator strength at smaller well width. (c) 2005 WILEY-VCH Verlag GmbH & Co. C1 USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, Adelphi, MD 20783 USA. Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. Univ Calif Santa Barbara, JST ERATO Grp, Santa Barbara, CA 93106 USA. Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA. RP Garrett, GA (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ggarrett@arl.army.mil RI Speck, James/H-5646-2011 NR 12 TC 10 Z9 10 U1 0 U2 6 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0031-8965 J9 PHYS STATUS SOLIDI A JI Phys. Status Solidi A-Appl. Mat. PD APR PY 2005 VL 202 IS 5 BP 846 EP 849 DI 10.1002/pssa.200461599 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 920HE UT WOS:000228679200033 ER PT J AU Brandt, HE AF Brandt, HE TI Quantum-cryptographic entangling probe SO PHYSICAL REVIEW A LA English DT Article AB For a general entangling probe attacking the Bennett-Brassard 1984 protocol in quantum key distribution, I calculate three classes of optimized unitary transformations, all yielding the same maximum information to the probe. The simplest one corresponds to a probe having a two-dimensional Hilbert space of states, and is uniquely determined by the error rate induced by the probe in the legitimate receiver. The second class corresponds to a probe having a four-dimensional Hilbert space of states, and is determined by the error rate and two continuous angle parameters which are mutually constrained by the error rate. The third class corresponds to a probe having a four-dimensional Hilbert space, and is determined by the error rate and two continuous angle parameters, one of which is constrained by the error rate. Furthermore, I show that the simplest quantum circuit representing the optimal entangling probe consists of a single controlled-NOT gate in which the control qubit consists of two polarization-basis states of the signal, the target qubit consists of two probe-basis states, and the initial state of the probe is set by the error rate. A method is determined for measuring the appropriate correlated state of the probe. Finally, a possible implementation of the entangling probe is described. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM hbrandt@arl.army.mil NR 13 TC 17 Z9 17 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD APR PY 2005 VL 71 IS 4 AR 042312 DI 10.1103/PhysRevA.71.042312 PG 14 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 921GR UT WOS:000228752700032 ER PT J AU D'Aguanno, G Mattiucci, N Scalora, M Bloemer, MJ AF D'Aguanno, G Mattiucci, N Scalora, M Bloemer, MJ TI TE and TM guided modes in an air waveguide with negative-index-material cladding SO PHYSICAL REVIEW E LA English DT Article ID REFRACTION; METAMATERIALS; DELIVERY; PERMITTIVITY; PERMEABILITY; GUIDANCE; FIBERS; LIGHT AB We numerically demonstrate that a planar waveguide in which the inner layer is a gas with refractive index n(0)=1, sandwiched between two identical semi-infinite layers of a negative index material, can support both transverse electric and transverse magnetic guided modes with low losses. Recent developments in the design of metamaterials with an effective negative index suggest that this waveguide could operate in the infrared region of the spectrum. C1 Time Domain Corp, Huntsville, AL 35806 USA. USA, Ctr Res Dev & Engn, Aviat & Missile Command, Redstone Arsenal, AL 35898 USA. Univ RomaTre, Dipartimento Fis E Amaldi, I-00146 Rome, Italy. RP D'Aguanno, G (reprint author), Time Domain Corp, Cummings Res Pk,7057 Old Madison Pike, Huntsville, AL 35806 USA. EM giuseppe.daguanno@timedomain.com OI D'Aguanno, Giuseppe/0000-0002-7132-0103 NR 30 TC 26 Z9 26 U1 1 U2 4 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1063-651X J9 PHYS REV E JI Phys. Rev. E PD APR PY 2005 VL 71 IS 4 AR 046603 DI 10.1103/PhysRevE.71.046603 PN 2 PG 7 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 921GP UT WOS:000228752500091 PM 15903802 ER PT J AU Bodo, M Pearce, FJ Baranyi, L Armonda, RA AF Bodo, M Pearce, FJ Baranyi, L Armonda, RA TI Changes in the intracranial rheoencephalogram at lower limit of cerebral blood flow autoregulation SO PHYSIOLOGICAL MEASUREMENT LA English DT Article; Proceedings Paper CT 12th International Conference on Electrical Bio-Impedance/5th Electrical Impedance Tomography Conference CY JUN 20-24, 2004 CL Gdansk, POLAND ID TRAUMATIC BRAIN-INJURY; ELECTRICAL-IMPEDANCE; PRESSURE AUTOREGULATION; HEMORRHAGIC HYPOTENSION; CLINICAL-APPLICATIONS; PERFUSION-PRESSURE; BIOPHYSICAL BASIS; ELECTRODE SIZE; HEAD-INJURY; TISSUE AB Cerebral blood flow (CBF) reactivity monitoring is an appropriate primary parameter to evaluate cerebral resuscitation due to a systemic or regional cerebral injury leading to possible irreversible brain injury. Use of the electrical impedance method to estimate CBF is rare, as the method's anatomical background is not well understood. Use of intracranial rheoencephalography (iREG) during hemorrhage and comparison of iREG to other CBF measurements have not been previously reported. Our hypothesis was that iREG would reflect early cerebrovascular alteration (CBF autoregulation). Studies comparing iREG, laser Doppler flowmetry and ultrasound were undertaken on anesthetized rats to define CBF changes during hemorrhage. Blood was removed at a rate required to achieve a mean arterial blood pressure (MABP) of 40 mm Hg over 15 min. Estimation of CBF was taken with intracranial, bipolar REG (REG I; n = 14), laser Doppler flowmetry (LDF; n = 3) and carotid flow by ultrasound (n = 11). Data were processed off-line. During the initial phase of hemorrhage, when MABP was close to 40 mm Hg, intracranial REG amplitude transiently increased (80.94%); LDF (77.92%) and carotid flow (52.04%) decreased and changed with systemic arterial pressure. Intracranial REG amplitude change suggests classical CBF autoregulation, demonstrating its close relationship to arteriolar changes. The studies indicate that iREG might reflect cerebrovascular responses more accurately than changes in local CBF measured by LDF and carotid flow. REG may indicate promise as a continuous, non-invasive life-sign monitoring tool with potential advantages over ultrasound, the CBF measurement technique normally applied in clinical practice. REG has particular advantages in non-hospital settings such as military and emergency medicine. C1 Walter Reed Army Inst Res, Dept Resuscitat Med, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Membrane Biochem, Silver Spring, MD 20910 USA. Walter Reed Army Med Ctr, Div Neurosurg, Natl Capital Consortium, Sect Cerebrovasc Surg & Intervent Neuroradiol, Washington, DC 20307 USA. RP Bodo, M (reprint author), Walter Reed Army Inst Res, Dept Resuscitat Med, Silver Spring, MD 20910 USA. EM michael.bodo@us.army.mil NR 112 TC 9 Z9 10 U1 0 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0967-3334 J9 PHYSIOL MEAS JI Physiol. Meas. PD APR PY 2005 VL 26 IS 2 SI SI BP S1 EP S17 DI 10.1088/0967-3334/26/2/001 PG 17 WC Biophysics; Engineering, Biomedical; Physiology SC Biophysics; Engineering; Physiology GA 918QW UT WOS:000228563700002 PM 15798222 ER PT J AU Lennox, WJ AF Lennox, WJ TI Romance and reality SO POETRY LA English DT Editorial Material C1 US Mil Acad, W Point, NY 10996 USA. RP Lennox, WJ (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU POETRY PI CHICAGO PA 60 W WALTON ST, CHICAGO, IL 60610 USA SN 0032-2032 J9 POETRY JI Poetry PD APR PY 2005 VL 186 IS 1 BP 58 EP 59 PG 2 WC Poetry SC Literature GA 908LC UT WOS:000227787500043 ER PT J AU Robbins, RG AF Robbins, RG TI 'The ticks (Acari : Ixodida : Argasidae, Ixodidae) of Taiwan: A synonymic checklist SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article DE ticks; Ixodida; checklist; synonymy; Taiwan ID IXODOIDEA-IXODIDAE; SP-N; LYME-DISEASE; HOSTS; JAPAN; IDENTITY; VIETNAM; SUPINO; CHINA; REDESCRIPTION AB Eleven checklists of Taiwanese ticks, published or privately circulated between 1935 and 1984, are compared with specimen records, chiefly in the U.S. National Tick Collection, yielding a list of 32 tick species thought to definitely occur in Taiwan and its adjacent islets: Argas pusillus Kohls, A. robertsi Hoogstraal, Kaiser & Kohls, Ornitbodoros capensis Neumann, Amblyomma cordiferum Neumann, A. geoemydae (Cantor). A. helvolum Koch, A. testudinarium Koch, Aponomma varanense (Supino), Boophilus microplus (Canestrini), Dermacentor taiwanensis Sugimoto, Haemaphysalis bandicota Hoogstraal & Kohls, H. canestrinii (Supino), H. doenitzi Warburton & Nuttall, H. flava Neumann. H. formosensis Neumann, H. hystricis Supino, H. kitaokai Hoogstraal, H. mageshintaensis Saito & Hoogstraal, H. ornithophila Hoogstraal & Kohls, H. phasiana Saito, Hoogstraal & Wassef, H. taiwana Sugimoto, H. yens Toumanoff, Ixodes acutitarsus (Karsch), I. granulatus Supino, I. kuntzi Hoogstraal & Kohls, I. nipponensis Kitaoka & Saito, I. ovatus Neumann, I. persulcatus Schulze, I. simplex Neumann, I. vespertilionis Koch. Rhipicephalus haemaphysaloides (Supino), and R. sanguineus (Latreille). An additional 13 tick species previously believed to occur in Taiwan are excluded from this list. C1 Walter Reed Army Med Ctr, Armed Forces Pest Management Board, Def Pest Managment Informat Anal Ctr, Washington, DC 20307 USA. RP Robbins, RG (reprint author), Walter Reed Army Med Ctr, Armed Forces Pest Management Board, Def Pest Managment Informat Anal Ctr, Washington, DC 20307 USA. NR 50 TC 18 Z9 30 U1 1 U2 5 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD APR PY 2005 VL 107 IS 2 BP 245 EP 253 PG 9 WC Entomology SC Entomology GA 915CL UT WOS:000228275100001 ER PT J AU Shkolnikov, IA Shtessel, YB Lianos, DP AF Shkolnikov, IA Shtessel, YB Lianos, DP TI Effect of sliding mode observers in the homing guidance loop SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART G-JOURNAL OF AEROSPACE ENGINEERING LA English DT Article DE homing guidance; sliding mode observers AB Application of a second-order sliding mode observer, which is based on the nonlinear dynamic sliding manifold, as a nonlinear uncertain system estimator in the homing (terminal guidance) loop with augmented proportional navigation guidance is demonstrated. It is shown that sliding mode observers have an advantage over traditional Kalman filters in the homing loop upon target maneuvering at a short time-to-go. C1 Univ Alabama, Dept Elect & Comp Engn, Huntsville, AL 35899 USA. USA, Space & Missile Def Command, Adv Technol Directorate, Huntsville, AL USA. RP Shtessel, YB (reprint author), Univ Alabama, Dept Elect & Comp Engn, Huntsville, AL 35899 USA. NR 10 TC 8 Z9 8 U1 0 U2 1 PU PROFESSIONAL ENGINEERING PUBLISHING LTD PI BURY ST EDMUNDS PA NORTHGATE AVENUE, BURY ST EDMUNDS IP32 6BW, SUFFOLK, ENGLAND SN 0954-4100 J9 P I MECH ENG G-J AER JI Proc. Inst. Mech. Eng. Part G-J. Aerosp. Eng. PD APR PY 2005 VL 219 IS G2 BP 103 EP 111 DI 10.1243/095441005X30199 PG 9 WC Engineering, Aerospace; Engineering, Mechanical SC Engineering GA 945ZI UT WOS:000230541100004 ER PT J AU Patterson, HS Sponaugle, DN AF Patterson, HS Sponaugle, DN TI Is infiltrate a useful term in the interpretation of chest radiographs? Physician survey results SO RADIOLOGY LA English DT Article ID FLEISCHNER-SOCIETY; NOMENCLATURE COMMITTEE; GLOSSARY; RECOMMENDATIONS; RADIOLOGY AB PURPOSE: To determine how physicians interpret the word infiltrate when it is used in a chest radiography report and if the word is helpful in the clinical management of patients. MATERIALS AND METHODS: Informed consent from participants was not required, and the study protocol was granted exempt status. One hundred sixty-five questionnaires were distributed, in conjunction with various physician meetings, at three separate nonaffiliated training hospitals. In the three-question survey, respondents were asked the definition of infiltrate, whether the term is helpful in guiding patient therapy, and whether it implies an etiology. The respondent demographic data obtained included date of graduation from medical school, amount of postgraduate training completed, primary or training specialty, and board or sub-board qualification. RESULTS: There were 151 physician respondents, 94 (62.3%) of whom were house staff members. One hundred fifteen (76%) responders chose bacterial pneumonia as a condition consistent with infiltrate. One hundred thirty (86.1%) respondents replied that infiltrate implied more than one pathophysiologic condition. Eighty-two (54.3%) of those surveyed thought infiltrate could mean any of six or more different pathophysiologic conditions, including nonspecific pneumonia, interstitial pneumonia, viral pneumonia, consolidation, or nonspecific interstitial process. The number of terms selected did not vary according to level of residency training (P=.23); however, there was a significant specialty-related difference in the number of terms selected (P=.018). Internists selected a median of 10 terms, while others selected a median of six. Only 54 (36%) respondents thought that the term infiltrate was helpful in patient care, and only five (3%) thought that the term implied an etiology. CONCLUSION: Infiltrate is a nonspecific and imprecise term when it is used as a radiograph descriptor, and use of this term does not usually enhance patient care. C1 Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Patterson, HS (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 16000 Georgia Ave, Washington, DC 20307 USA. EM harlan.patterson@na.amedd.army.mil NR 8 TC 13 Z9 13 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0033-8419 J9 RADIOLOGY JI Radiology PD APR PY 2005 VL 235 IS 1 BP 5 EP 8 DI 10.1148/radiol.2351020759 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 910SN UT WOS:000227952600003 PM 15798161 ER PT J AU Wilson, RL Lettieri, CJ Fitzpatrick, TM Shorr, AF AF Wilson, RL Lettieri, CJ Fitzpatrick, TM Shorr, AF TI Intralobular bronchopulmonary sequestrations associated with bronchogenic cysts SO RESPIRATORY MEDICINE LA English DT Editorial Material DE intralobular; extralobular; bronchopulmonary sequestration; congenital; cysts; foregut ID EXPERIENCE; DIAGNOSIS; CHILDREN; DISEASE AB We present three cases of intralobar bronchopulmonary sequestrations with associated congenital bronchogenic cysts. As congenital abnormalities tend to be found together, these cases question the notion that intralobar sequestrations only occur secondary to chronic inflammation or infection, and suggest they can be congenital Lesions. Published by Elsevier Ltd. C1 Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pulm & Crit Care Med, Washington, DC 20307 USA. RP Wilson, RL (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, 6900 Georgia Ave, Washington, DC 20307 USA. EM ramey.wilson@us.army.mil NR 14 TC 7 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0954-6111 J9 RESP MED JI Respir. Med. PD APR PY 2005 VL 99 IS 4 BP 508 EP 510 DI 10.1016/j.rmed.2004.08.014 PG 3 WC Cardiac & Cardiovascular Systems; Respiratory System SC Cardiovascular System & Cardiology; Respiratory System GA 915LH UT WOS:000228305200018 PM 15763459 ER PT J AU Kipp, JW AF Kipp, JW TI 'Storm of steel': The development of armor doctrine in Germany and the Soviet Union, 1919-1939. SO RUSSIAN REVIEW LA English DT Book Review C1 Foreign Mil Studies Off, Ft Leavenworth, KS USA. RP Kipp, JW (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD APR PY 2005 VL 64 IS 2 BP 352 EP 353 PG 2 WC History SC History GA 909KP UT WOS:000227859100029 ER PT J AU Niebuhr, DW Yolken, RH Millikan, AM Cowan, DN Li, Y AF Niebuhr, DW Yolken, RH Millikan, AM Cowan, DN Li, Y TI The military new-onset psychosis project - A resource for the study of gene-environment interactions among persons with severe mental illness SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 20th International Congress on Schizophernia Research CY APR 02-06, 2005 CL Savannah, GA C1 Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD APR PY 2005 VL 31 IS 2 BP 233 EP 233 PG 1 WC Psychiatry SC Psychiatry GA 914PY UT WOS:000228241200140 ER PT J AU Handrigan, MT Bentley, TB Oliver, JD Tabaku, LS Burge, JR Atkins, JL AF Handrigan, MT Bentley, TB Oliver, JD Tabaku, LS Burge, JR Atkins, JL TI Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake rats SO SHOCK LA English DT Article DE shock; hemorrhage; resuscitation; hypotensive resuscitation; intravenous fluid; hydroxyethyl starch; lactated Ringer's solution; hemoglobin-based oxygen carrier ID HUMAN POLYMERIZED HEMOGLOBIN; BLOOD SUBSTITUTE; COMBAT CASUALTIES; TRAUMA; INJURY; SHOCK; MODEL; BATTLEFIELD; PRESSURE; SURVIVAL AB Hypotensive resuscitation (Hypo) has been considered an alternate resuscitation strategy in clinical settings that prevent the application of standard Advanced Trauma Life Support care. However, validation of this approach when used for prolonged periods of time remains to be demonstrated. The purpose of this study was to evaluate prolonged Hypo as an alternative to standard resuscitation using various currently available resuscitative fluids. Unanesthetized, male Sprague-Dawley rats underwent computer-controlled hemorrhagic shock and resuscitation. There were six experimental groups; nonhemorrhage (NH), nonresuscitated control (C), Hypo with lactated Ringer's (Hypol-R), Hypo with Hextend (R), 6% hydroxyethyl starch in a balanced salt solution (HEX), Hypo with PolyHeme (R), a polymerized hemoglobin solution (HBOC), or standard resuscitation with LR (StandLR). Animals were bled over 15 min to a mean arterial blood pressure (MAP) of 40 mmHg where the blood pressure (BP) was held for 30 min. Hypo groups were resuscitated to 60 mmHg for 4 h followed by further resuscitation to 80 mmHg. StandLR rats were resuscitated to 80 mmHg immediately after the hemorrhage period. Animals were monitored until death or they were sacrifice at 24 h. Prolonged Hypo with HEX or LR resulted in a trend toward improved 24-h survival compared with C (71%, 65%, and 48%, respectively), and performed at least as well as StandLR (58% survival). HEX required significantly less intravenous fluid (0.7 x total estimated blood volume [EBV]) compared with HypoLR (1.9 x EBV) and StandLR (3.2 x EBV) (P < 0.05). Although HBOC required the smallest fluid volume (0.4 x EBV), survival was no better than C and it resulted in the most significant acidosis. These results support the decision to use Hextend for Hypo, a strategy currently being applied on the battlefield. C1 Walter Reed Army Inst Res, Div Mil Casualty Res, Med Corp, Silver Spring, MD 20910 USA. RP Handrigan, MT (reprint author), Walter Reed Army Inst Res, Div Mil Casualty Res, Med Corp, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM michael.handrigan@na.amedd.army.mil RI Atkins, James/B-3577-2011 NR 36 TC 55 Z9 61 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD APR PY 2005 VL 23 IS 4 BP 337 EP 343 DI 10.1097/01.shk.0000156667.04628.1f PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 913AU UT WOS:000228123100008 PM 15803057 ER PT J AU Rossman, EJ AF Rossman, EJ TI Natural assets: Democratizing environmental ownership SO SOCIETY & NATURAL RESOURCES LA English DT Book Review C1 USA, Corps Engineers, Tulsa Dist, Tulsa, OK USA. RP Rossman, EJ (reprint author), USA, Corps Engineers, Tulsa Dist, Tulsa, OK USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0894-1920 J9 SOC NATUR RESOUR JI Soc. Nat. Resour. PD APR PY 2005 VL 18 IS 4 BP 395 EP 398 PG 4 WC Environmental Studies; Planning & Development; Sociology SC Environmental Sciences & Ecology; Public Administration; Sociology GA 912ET UT WOS:000228061100009 ER PT J AU Taylor, SF Patel, PR Herold, TJ AF Taylor, SF Patel, PR Herold, TJ TI Recurrent Arthralgias in a patient with previous mayaro fever infection SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE arthropathy; Mayaro; military medicine; mosquitoborne; tropical medicine ID VIRUS-DISEASE; OUTBREAK; BELTERRA; BRAZIL; ARTHROPATHY AB Mayaro fever is an acute, self-limited, febrile, mosquito-borne viral disease manifested by fever, chills, headache, myalgias, and arthralgias. The virus belongs to the family Togaviridae and the genus Alphavirus. Five other mosquito-borne viruses have been described as causing a similar dengue-like illness. The virus was first isolated in 1954, and the first epidemics were described in 1955 in Brazil and Bolivia. Other cases have been reported in Suriname, Brazil, Peru, French Guiana, and Trinidad. Up to 10 to 15% of febrile illnesses in endemic areas have been attributed to Mayaro virus. The exact pathogenesis and pathophysiology among humans is unknown. Animal models have demonstrated necrosis of skeletal muscle, periosteum, perichondrial tissues, and evidence of meningitis and encephalitis. All previous cases of Mayaro fever describe a self-limited illness. No reports of recurrent symptoms exist in the literature. This report describes a case of recurrent arthralgias in a military service member presenting to the emergency department. C1 Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. Darnall Army Community Hosp, Dept Emergency Med, Ft Hood, TX USA. RP Taylor, SF (reprint author), 11 Lakeview Dr, Whispering Pines, NC 28327 USA. EM shawnft@aol.com NR 11 TC 15 Z9 17 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD APR PY 2005 VL 98 IS 4 BP 484 EP 485 DI 10.1097/01.SMJ.0000145879.14102.F4 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 918RY UT WOS:000228566500022 PM 15898531 ER PT J AU Ellzy, MW Christesen, SD Jensen, JO Kay, JG AF Ellzy, MW Christesen, SD Jensen, JO Kay, JG TI Vibrational frequencies and structural determinations of divinyl sulfoxide SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY LA English DT Article DE infrared spectroscopy; computational chemistry; vibrational frequencies; vinyl sulfoxide; structural transformation; optimized geometry; divinyl sulfoxide; Moller-Plesset; Becke(3)-Lee-Yang-Parr ID SPECTROMETRY; SULFONE AB We present a detailed analysis of the structure and infrared spectra of divinyl sulfoxide. The vibrational frequencies of the divinyl sulfoxide molecule were analyzed using standard quantum chemical techniques. Frequencies were calculated at the MP2 and DFT levels of theory using the standard 6-311 G* basis set. The molecule exists normally in a C-s configuration. High-energy forms of divinyl sulfoxide with Cs and C, symmetries also exist. (c) 2004 Elsevier B.V. All rights reserved. C1 USA, Edgewood Chem & Biol Command, Aberdeen Proving Ground, MD 21010 USA. Drexel Univ, Dept Chem, Philadelphia, PA 19104 USA. RP Ellzy, MW (reprint author), USA, Edgewood Chem & Biol Command, Aberdeen Proving Ground, MD 21010 USA. EM mwellzy@sbccom.apgea.army.mil NR 20 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1386-1425 J9 SPECTROCHIM ACTA A JI Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. PD APR PY 2005 VL 61 IS 6 BP 1075 EP 1087 DI 10.1016/j.saa.2004.06.024 PG 13 WC Spectroscopy SC Spectroscopy GA 909HY UT WOS:000227852200009 PM 15741105 ER PT J AU Donovan, DJ AF Donovan, DJ TI Simple depressed skull fracture causing sagittal sinus stenosis and increased intracranial pressure: case report and review of the literature SO SURGICAL NEUROLOGY LA English DT Review DE head trauma; depressed skull fracture; sagittal sinus stenosis ID HYPERTENSION; MANAGEMENT; OCCLUSION AB The surgical management of depressed skull fractures is determined in part by whether a fracture is open or closed. Open fractures are usually elevated surgically, but closed fractures are most often treated nonoperatively, and the only 2 indications commonly described for operative treatment of closed fractures are hematoma evacuation and correction of cosmetic deformity. There is another indication, however, that is occasionally encountered when a depressed skull fracture injures a venous sinus. This injury can result in venous sinus stenosis, leading to venous hypertension and elevated intracranial pressure (ICP). A case is presented of closed depressed fracture of the midline skull, causing compressive stenosis of the superior sagittal sinus (SSS), venous hypertension, and encephalopathy. The fracture was surgically elevated to relieve the compression of the SSS and the encephalopathy resolved. The clinical identification, the imaging, and the risks and benefits of operative repair of this condition are reviewed. Increased ICP secondary to venous sinus injury is not commonly described in association with closed depressed skull fractures, but should always be considered in patients with the appropriate clinical findings when a fracture overlies a venous sinus, even in the absence of a hematoma. Published by Elsevier Inc. C1 Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Donovan, DJ (reprint author), Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. EM daniel.donovan@amedd.army.mil NR 19 TC 7 Z9 8 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-3019 J9 SURG NEUROL JI Surg. Neurol. PD APR PY 2005 VL 63 IS 4 BP 380 EP 383 DI 10.1016/j.surneu.2004.06.020 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 916EY UT WOS:000228369400032 PM 15808730 ER PT J AU Penko, K Livezey, J Fenton, C Patel, A Nicholson, D Flora, M Oakley, K Tuttle, RM Francis, G AF Penko, K Livezey, J Fenton, C Patel, A Nicholson, D Flora, M Oakley, K Tuttle, RM Francis, G TI BRAF mutations are uncommon in papillary thyroid cancer of young patients SO THYROID LA English DT Article ID TYROSINE KINASE; RET PROTOONCOGENE; CLINICAL-COURSE; HIGH PREVALENCE; CARCINOMAS; CHILDREN; RET/PTC; EXPRESSION; GENE; REARRANGEMENTS AB Mortality is low for young patients (younger than 21 years) with papillary thyroid cancer (PTC), and different mutations might contribute to this. Previous studies detected ret/PTC rearrangements more frequently in PTC from children than adults, and recent reports describe a high incidence of BRAF T1796A transversion in adult PTC. However, BRAF mutations have not been adequately studied in PTC from young patients. We amplified and sequenced segments of the BRAF gene spanning the T1796A transversion site in 14 PTC from patients 10-21 years of age (mean, 17.5 &PLUSMN; 3.5 years). The PTC (7 = class 1; 5 = class 2; 1 = class 3) ranged from 0.7-2.9 cm in diameter (mean, 1.4 &PLUSMN; 0.75 cm). None of them (0/14) contained BRAF T1796A and none recurred (mean follow-up, 66 40 months). This incidence of BRAF T1796A is significantly less than that reported for adult PTC (270/699, 38.6%, p = 0.0015) in several series. None of our PTC (0/10) contained ras mutations, but 7/12 (58%) contained ret/PTC rearrangements. We conclude that BRAF mutations are less common in PTC from young patients, and ret/PTC rearrangements were the most common mutation found in these childhood PTC. C1 Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Biomed Instrumentat Ctr, Bethesda, MD USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Mem Sloan Kettering Canc Ctr, Dept Endocrinol, New York, NY USA. RP Francis, G (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM gfrancis@usuhs.mil RI Vogt, Karen/D-6771-2017 OI Vogt, Karen/0000-0001-7676-0581 NR 34 TC 53 Z9 57 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1050-7256 J9 THYROID JI Thyroid PD APR PY 2005 VL 15 IS 4 BP 320 EP 325 DI 10.1089/thy.2005.15.320 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 926SQ UT WOS:000229143400005 PM 15876153 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of Ge3O3 SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; germanium monoxide trimer; germanium oxide ID MOLECULES; OXIDES AB The normal mode frequencies and corresponding vibrational assignments of the germanium monoxide trimer (Ge3O3) in D-3h symmetry are examined theoretically using the GAUSSIAN03 set of quantum chemistry codes. All normal modes were successfully assigned to one of three types of motion (Ge-O stretch, Ge-O-Ge bend, and out-of-plane bending) predicted by a group theoretical analysis. Comparing the vibrational frequencies with IR and Raman spectra available in the literature, scaling factors are derived. Molecular orbitals and bonding are examined. (c) 2005 Elsevier B.V. All rights reserved. C1 USA, Edgewood Chem & Biol Ctr, AMSRD, ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD, ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 14 TC 2 Z9 2 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD MAR 31 PY 2005 VL 718 IS 1-3 BP 203 EP 207 DI 10.1016/j.theochem.2004.11.035 PG 5 WC Chemistry, Physical SC Chemistry GA 914XW UT WOS:000228262400023 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of tellurophene SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; tellurophene; telluracyclopentadiene ID HETEROCYCLIC ORGANOTELLURIUM COMPOUNDS; 5-MEMBERED RING-SYSTEMS; FORCE-FIELD CALCULATION; 2ND HYPERPOLARIZABILITY; FURAN HOMOLOGS; TE ANALOGS; C4H4X X; SELENOPHENE; SE; DERIVATIVES AB The normal mode frequencies and corresponding vibrational assignments of tellurophene are examined theoretically using the GAUSSIAN 98 set of quantum chemistry codes. All normal modes were successfully assigned to one of eight types of motion (C-H stretch, C=C stretch, C-C stretch, Te-C stretch, in-plane C-H bend, out-of-plane C-H bend, C=C-C bend, and ring torsion) utilizing the C-2v symmetry of the molecule. Calculations were performed at the Hartree-Fock, DFT (B3LYP), and MP2 levels of theory using the standard SDD core potential and basis set. Theoretical results were successfully compared against available experimental data. Molecular orbitals and bonding were examined. (c) 2005 Elsevier B.V. All rights reserved. C1 USA, Edgewood Chem & Biol Ctr, AMSRD, ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD, ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 48 TC 1 Z9 1 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD MAR 31 PY 2005 VL 718 IS 1-3 BP 209 EP 218 DI 10.1016/j.theochem.2004.11.036 PG 10 WC Chemistry, Physical SC Chemistry GA 914XW UT WOS:000228262400024 ER PT J AU Okovytyy, S Kholod, Y Qasim, M Fredrickson, H Leszczynski, J AF Okovytyy, S Kholod, Y Qasim, M Fredrickson, H Leszczynski, J TI The mechanism of unimolecular decomposition of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane. A computational DFT study SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID PHASE ALPHA-HMX; AB-INITIO DYNAMICS; GAS-PHASE; ORGANIC-MOLECULES; RATE CONSTANTS; RDX; HNIW; CL-20; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; CONFORMATIONS AB By using the B3LYP level of density functional theory, possible decomposition reaction pathways of 2,4,6,8,10, 12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) in the gas phase have been investigated. We have found several types of reactions for this process: homolytic cleavage of an N-N bond to form the NO2center dot group; HONO elimination; C-C and C-N bonds breaking leading to ring opening; and H-migration. On the basis of the results of computation scanning of the potential energy surface, the most favorite pathway of CL-20 unimolecular decomposition that results in the formation of the stable aromatic compound 1,5-dihydrodiimidazo[4,5-b:4',5'-e]pyrazine has been proposed. C1 Jackson State Univ, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. Dnepropetrovsk Natl Univ, UA-49050 Dnepropetrovsk, Ukraine. USA, ERDC, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. EM jerzy@ccmsi.us RI Okovytyy, Sergiy/F-9838-2010 OI Okovytyy, Sergiy/0000-0003-4367-1309 NR 42 TC 31 Z9 35 U1 3 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD MAR 31 PY 2005 VL 109 IS 12 BP 2964 EP 2970 DI 10.1021/jp045292v PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 911HQ UT WOS:000227993600036 PM 16833616 ER PT J AU Karnasuta, C Paris, RM Cox, JH Nitayaphan, S Pitisuttithum, P Thongcharoen, P Brown, AE Gurunathan, S Tartaglia, J Heyward, WL McNeil, JG Birx, DL de Souza, MS AF Karnasuta, C Paris, RM Cox, JH Nitayaphan, S Pitisuttithum, P Thongcharoen, P Brown, AE Gurunathan, S Tartaglia, J Heyward, WL McNeil, JG Birx, DL de Souza, MS CA TAVEGThai AIDS Vaccine Evaluation TI Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in a phase I/II ALVAC-HIV/AIDSVAX((R)) B/E prime-boost HIV-1 vaccine trial in Thailand SO VACCINE LA English DT Article DE ADCC; HIV-1; prime-boost vaccine ID HUMORAL IMMUNE-RESPONSES; SIMPLEX-VIRUS TYPE-2; DISEASE PROGRESSION; SEROPOSITIVE INDIVIDUALS; LYMPHOCYTE COUNTS; HOST FACTORS; ADCC; INFECTION; MOTHERS; PATHOGENESIS AB Antibody-dependent cell-mediated cytotoxicity (ADCC) was assessed in volunteers participating in an ALVAC-HIV (vCP1521)/-AIDSVAX (R) B/E gp120 prime-boost vaccine trial in Thailand. ADCC activity was measured using chromium release from gp120 subtype B- and CRF01_AE-coated targets in 95 vaccinces and 28 placebo recipients. There was a significant difference in the magnitude of the ADCC response to both targets between vaccinees and placebo recipients. The frequency of responders to subtype B and to CRF01_AE was 96% and 84% in the vaccine group versus 11% and 7% in the placebo group. The results demonstrate that this HIV vaccine is a potent inducer of ADCC activity and may be an additional protection of this prime-boost vaccine in preventing HIV disease. Published by Elsevier Ltd. C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. US Mil HIV Res Programme, Rockville, MD USA. Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand. Mahidol Univ, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand. Aventis Pasteur, Swiftwater, PA USA. Aventis Pasteur, Toronto, ON, Canada. VaxGen, Brisbane, CA USA. RP Karnasuta, C (reprint author), Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. EM chitrapornk@afrims.org NR 46 TC 76 Z9 80 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAR 31 PY 2005 VL 23 IS 19 BP 2522 EP 2529 DI 10.1016/j.vaccine.2004.10.028 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 909ZI UT WOS:000227898800014 PM 15752839 ER PT J AU Garbuzov, D Kudryashov, I Dubinskii, M AF Garbuzov, D Kudryashov, I Dubinskii, M TI Resonantly diode laser pumped 1.6-mu m-erbium-doped yttrium aluminum garnet solid-state laser SO APPLIED PHYSICS LETTERS LA English DT Article AB We report direct resonant diode pumping of a 1.6-mu m-Er3+-doped bulk solid-state laser. Using a 1470-nm-single-mode diode laser module to pump the Er:YAG rod, an absorbed photon conversion efficiency of 26% has been obtained in this initial experiment. Analysis of the diode-pumped solid-state laser input-output characteristics suggests that the obtained slope efficiency can be doubled through the reduction of intracavity losses and pumping efficiency improvement. (C) 2005 American Institute of Physics. C1 Princeton Lightwave Inc, Cranbury, NJ 08512 USA. USA, Res Lab, UMSRD ARL SE EO, Adelphi, MD 20783 USA. RP Garbuzov, D (reprint author), Princeton Lightwave Inc, 2555 US Route 130, Cranbury, NJ 08512 USA. EM dgarbuzov@princetonlightwave.com NR 12 TC 40 Z9 40 U1 2 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 28 PY 2005 VL 86 IS 13 AR 131115 DI 10.1063/1.1898427 PG 3 WC Physics, Applied SC Physics GA 916YL UT WOS:000228422600015 ER PT J AU Campiani, G Fattorusso, C Butini, S Gaeta, A Agnusdei, M Gemma, S Persico, M Catalanotti, B Savini, L Nacci, V Novellino, E Holloway, HW Greig, NH Belinskaya, T Fedorko, JM Saxena, A AF Campiani, G Fattorusso, C Butini, S Gaeta, A Agnusdei, M Gemma, S Persico, M Catalanotti, B Savini, L Nacci, V Novellino, E Holloway, HW Greig, NH Belinskaya, T Fedorko, JM Saxena, A TI Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE; CHOLINESTERASES; SIMULATIONS; BINDING AB Tacrine heterobivalent ligands were designed as novel and reversible inhibitors of cholinesterases. On the basis of the investigation of the active site gorge topology of butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE) and by using flexible docking procedures, molecular modeling studies formulated the hypothesis of extra interaction sites in the active gorge of hBuChE, namely, a mid-gorge interaction site and a peripheral interaction site. The design strategy led to novel BuChE inhibitors, balancing potency and selectivity. Among the compounds identified, the heterobivalent ligand 4m, containing an amide nitrogen and a sulfur atom at the 8-membered tether level, is one of the most potent and selective BuChE inhibitors described to date. The novel inhibitors, bearing postulated key features, validated the hypothesis of the presence of extra interaction sites within the hBuChE active site gorge. C1 Univ Siena, Dipartimento Farmacochim Tecnol, I-53100 Siena, Italy. Univ Siena, European Res Ctr Drug Discovery & Dev NatSynDrugs, I-53100 Siena, Italy. Univ Naples Federico II, Dipartimento Chim Sostanze Nat, Naples, Italy. Univ Naples Federico II, Dipartimento Chim Farmaceut & Tossicol, I-80131 Naples, Italy. NIA, Drug Design & Dev Sect, Intramural Res Program, Baltimore, MD 21224 USA. Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Campiani, G (reprint author), Univ Siena, Dipartimento Farmacochim Tecnol, Via Aldo Moro, I-53100 Siena, Italy. EM campiani@unisi.it RI Gemma, Sandra/D-3568-2009; Persico, Marco/L-8448-2014; butini, stefania/D-9954-2015; fattorusso, caterina/F-7113-2015; Catalanotti, Bruno/D-4025-2016 OI Gemma, Sandra/0000-0002-8313-2417; Persico, Marco/0000-0003-0010-0338; fattorusso, caterina/0000-0003-3330-4281; Catalanotti, Bruno/0000-0002-7532-6959 NR 21 TC 60 Z9 60 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD MAR 24 PY 2005 VL 48 IS 6 BP 1919 EP 1929 DI 10.1021/jm049510k PG 11 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 907WR UT WOS:000227749300029 PM 15771436 ER PT J AU Lee, MS Olson, MA AF Lee, MS Olson, MA TI Evaluation of poisson solvation models using a hybrid explicit/implicit solvent method SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; GENERALIZED BORN MODEL; CONTINUUM ELECTROSTATICS MODELS; CHARGING FREE-ENERGIES; COMPUTER-SIMULATIONS; BOUNDARY-CONDITIONS; PROTEIN STABILITY; EXPLICIT SOLVENT; REACTION FIELD; BETA-HAIRPIN AB Implicit solvent methods have become popular tools in the field of protein dynamics simulations, yet evaluation of their validity has been primarily limited to comparisons with experimental and theoretical data for small molecules. In this paper, we use a recently developed hybrid explicit/implicit solvent methodology to evaluate the accuracy of several Poisson-based implicit solvent models. Specifically, we focus on the calculation of electrostatic solvation free energies of various fixed conformations for two proteins. We show that, among various dielectric boundary definitions, the Lee-Richards molecular surface has the best agreement with hybrid solvent results. Furthermore, certain modifications of the molecular surface Poisson protocol provide varied results. For instance, simple modifications of atomic radii on charged residues generally improve absolute errors but do not significantly reduce relative errors among conformations. On the other hand, using a waterprobe radius of 1.0 angstrom, as opposed to the standard value of 1.4 angstrom, to generate the molecular surface, moderately improves both absolute and relative results. C1 USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Lee, MS (reprint author), USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, 1425 Porter St, Ft Detrick, MD 21702 USA. EM michael.lee@amedd.army.mil NR 87 TC 52 Z9 52 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD MAR 24 PY 2005 VL 109 IS 11 BP 5223 EP 5236 DI 10.1021/jp046377z PG 14 WC Chemistry, Physical SC Chemistry GA 907RB UT WOS:000227734500058 PM 16863188 ER PT J AU Wolfenstine, J Allen, J AF Wolfenstine, J Allen, J TI Ni3+/Ni2+ redox potential in LiNiPO4 SO JOURNAL OF POWER SOURCES LA English DT Letter DE cathode; Li-ion batteries; redox potential; olivine; LiNiPO4 ID LITHIUM SECONDARY BATTERIES; CATHODES; PHOSPHATES; LICOPO4; LIMPO4 C1 AMSRD ARL SE DC, Army Res Lab, Adelphi, MD 20783 USA. RP Wolfenstine, J (reprint author), AMSRD ARL SE DC, Army Res Lab, Adelphi, MD 20783 USA. EM jwolfenstine@arl.army.mil NR 18 TC 142 Z9 147 U1 7 U2 113 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD MAR 24 PY 2005 VL 142 IS 1-2 BP 389 EP 390 DI 10.1016/j.jpowsour.2004.11.024 PG 2 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 916YK UT WOS:000228422500045 ER PT J AU Seo, DW Chang, GY AF Seo, DW Chang, GY TI Missing nail for 22 years SO NEUROLOGY LA English DT Editorial Material C1 USA, Gen Hosp, HHC 121st, APO, AP 96205 USA. RP Chang, GY (reprint author), USA, Gen Hosp, HHC 121st, Box 277, APO, AP 96205 USA. EM gychang@operamail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAR 22 PY 2005 VL 64 IS 6 BP 1066 EP 1066 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA 908RH UT WOS:000227806600028 PM 15781830 ER PT J AU Cook, BP Everitt, HO Avrutsky, I Osinsky, A Cai, A Muth, JF AF Cook, BP Everitt, HO Avrutsky, I Osinsky, A Cai, A Muth, JF TI Refractive indices of ZnSiN2 on r-plane sapphire SO APPLIED PHYSICS LETTERS LA English DT Article AB II-IV-N-2 wide band gap semiconductors such as ZnSiN2, ZnGeN2, and ZnSiGeN2 have potential uses for nonlinear materials and as lattice matching compounds for the growth of SiC and GaN devices. In this study, the dispersion of the TE and TM indices of refraction has been measured systematically using the prism coupling technique for an orthorhombic ZnSiN2 epitaxial layer grown on r-plane sapphire. The resulting index dispersion is extracted from the measured optical modes using a layered biaxial waveguide analysis, which shows that although the ZnSiN2 crystal is orthorhombic, for practical purposes it can be treated as a uniaxial material. (C) 2005 American Institute of Physics. C1 Univ Calif Los Angeles, Dept Math, Los Angeles, CA 90095 USA. Duke Univ, Dept Phys, Durham, NC 27708 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. Wayne State Univ, Dept Elect & Comp Engn, Detroit, MI 48202 USA. Corning Inc, Sci & Technol Grp, Corning, NY 14831 USA. N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. RP Cook, BP (reprint author), Univ Calif Los Angeles, Dept Math, Los Angeles, CA 90095 USA. EM muth@unity.ncsu.edu RI Everitt, Henry/L-7118-2013; Muth, John/E-9027-2012 OI Everitt, Henry/0000-0002-8141-3768; Muth, John/0000-0002-2488-7721 NR 14 TC 6 Z9 6 U1 2 U2 10 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 21 PY 2005 VL 86 IS 12 AR 121906 DI 10.1063/1.1865325 PG 3 WC Physics, Applied SC Physics GA 912BA UT WOS:000228050900022 ER PT J AU Baskaran, D Dunlap, JR Mays, JW Bratcher, MS AF Baskaran, D Dunlap, JR Mays, JW Bratcher, MS TI Grafting efficiency of hydroxy-terminated poly(methyl methacrylate) with multiwalled carbon nanotubes SO MACROMOLECULAR RAPID COMMUNICATIONS LA English DT Article DE carbon nanotubes; graft copolymers; nanotechnology; poly(methyl methacrylate); thermogravimetric analysis (TGA) ID TRANSFER RADICAL POLYMERIZATION; FUNCTIONALIZATION; SOLUBILIZATION AB Poly(methyl methacrylate)s (PMMAs) containing a terminal hydroxy group or multiple hydroxy groups as pendants were grafted to multiwalled carbon nanotubes (MWNTSs) by esterification in toluene at 100 degrees C. The recovered polymer with a low level of MWNTs and the PMMA-g-MWNTs with up to 12 wt.-% grafted polymer were characterized using spectroscopic, microscopic, and thermogravimetric analyses. The percentage of polymer present in the PMMA-g-MWNT samples is very low based upon the concentration of the acid groups in the tubes. C1 Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA. Univ Tennessee, Program Microscopy, Knoxville, TN 37996 USA. Oak Ridge Natl Lab, Div Chem Sci, Oak Ridge, TN 37831 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Baskaran, D (reprint author), Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA. EM baskaran@utk.edu RI Durairaj, Baskaran/C-3692-2009 OI Durairaj, Baskaran/0000-0002-6886-5604 NR 17 TC 51 Z9 51 U1 1 U2 14 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1022-1336 J9 MACROMOL RAPID COMM JI Macromol. Rapid Commun. PD MAR 18 PY 2005 VL 26 IS 6 BP 481 EP 486 DI 10.1002/marc.200400564 PG 6 WC Polymer Science SC Polymer Science GA 914LS UT WOS:000228229800011 ER PT J AU Poland, GA Grabenstein, JD Neff, JM AF Poland, GA Grabenstein, JD Neff, JM TI The US smallpox vaccination program: a review of a large modern era smallpox vaccination implementation program SO VACCINE LA English DT Article; Proceedings Paper CT 4th World Congress on Vaccines and Immunisation (WCVI) CY SEP 30-OCT 03, 2004 CL Tokyo, JAPAN SP Infect Control World Org, Minist Hlth, Labour Welfare, Minist Educ, Sci & Technol DE smallpox vaccine; smallpox; smallpox vaccine side effects ID COMPLICATIONS AB We describe the US experience with a large-scale smallpox vaccination program in the modem era and quantify the anticipated and unanticipated local and systemic side-effects of smallpox vaccination. In addition, we review unexpected issues, such as the development of myopericarditis discovered during the implementation of this program. These results constitute the largest dataset of a vaccinia vaccination program utilizing calf-lymph derived New York City Board of Health strain vaccine (Dryvax, Wyeth) since the 1970s. These results should inform current and future vaccinia vaccination programs and provide a historical rate of complications against which candidate vaccine side-effects can be compared in future clinical trials. (c) 2005 Elsevier Ltd. All rights reserved. C1 Mayo Clin & Mayo Fdn, Mayo Vaccine Res Grp, Minneapolis, MN USA. Mayo Clin & Mayo Fdn, Dept Med, Program Translat Immunovirol & Biodef, Minneapolis, MN USA. USA, Surg Gen Off, Mil Vaccine Agcy, Falls Church, VA USA. Childrens Hosp & Reg Med Ctr, Ctr Children Special Needs, Seattle, WA USA. RP Poland, GA (reprint author), Mayo Clin & Mayo Fdn, Mayo Vaccine Res Grp, 611 C Guggenheim Bldg,200 1st St SW, Minneapolis, MN USA. EM poland.gregory@mayo.edu NR 12 TC 80 Z9 83 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 18 PY 2005 VL 23 IS 17-18 BP 2078 EP 2081 DI 10.1016/j.vaccine.2005.01.012 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 909ZH UT WOS:000227898700012 PM 15755574 ER PT J AU Duffy, PE Krzych, U Francis, S Fried, M AF Duffy, PE Krzych, U Francis, S Fried, M TI Malaria vaccines: using models of immunity and functional genomics tools to accelerate the development of vaccines against Plasmodium falciparum SO VACCINE LA English DT Article; Proceedings Paper CT 4th World Congress on Vaccines and Immunisation (WCVI) CY SEP 30-OCT 03, 2004 CL Tokyo, JAPAN SP Infect Control World Org, Minist Hlth, Labour Welfare, Minist Educ, Sci & Technol DE Plasmodium falciparum; malaria; vaccine; functional genomics ID DIFFERENTIALLY EXPRESSED GENES; SUPPRESSION SUBTRACTIVE HYBRIDIZATION; CHONDROITIN SULFATE-A; IRRADIATED SPOROZOITES; PROTECTIVE IMMUNITY; PROTEOMICS APPROACH; MASS-SPECTROMETRY; CDNA MICROARRAY; LIVER STAGES; LIFE-CYCLE AB Naturally acquired immunity and immunity acquired after immunization with attenuated parasites indicate that a vaccine against malaria is feasible. Several obstacles have stymied malaria vaccine development, among them our poor understanding of protective immunity and technical difficulties for studying gene and protein expression in the Plasmodium falciparum parasite. Pregnancy malaria offers a model approach for vaccine development: recent findings have elucidated the basis for disease pathogenesis and protective immunity in this syndrome, and this understanding has focused the effort to identify the optimal antigens for a pregnancy malaria vaccine. In parallel, functional genomics tools are overcoming several of the obstacles for studying protein expression in the malaria parasite, vastly accelerating the pace for antigen discovery. Together, these conceptual and technological advances allow a rational approach to vaccine antigen selection, in which a finite number of antigens are selected from the entire genome by merit of the expression patterns and specific features. These candidate antigens are then subjected to detailed studies according to criteria established by the understanding of pathogenesis and protective immunity, to identify the optimal antigens for inclusion in subunit vaccines. Published by Elsevier Ltd. C1 Seattle Biomed Res Inst, Seattle, WA 98109 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, 307 Westlake Ave N,Suite 500, Seattle, WA 98109 USA. EM Patrick.duffy@sbri.org FU NIAID NIH HHS [R01 AI46438]; PHS HHS [R0152059] NR 49 TC 8 Z9 9 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 18 PY 2005 VL 23 IS 17-18 BP 2235 EP 2242 DI 10.1016/j.vaccine.2005.01.046 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 909ZH UT WOS:000227898700041 PM 15755603 ER PT J AU Heppner, DG Kester, KE Ockenhouse, CF Tornieporth, N Ofori, O Lyon, JA Stewart, VA Dubois, P Lanar, DE Krzych, U Moris, P Angov, E Cummings, JF Leach, A Hall, BT Dutta, S Schwenk, R Hillier, C Barbosa, A Ware, LA Nair, L Darko, CA Withers, MR Ogutu, B Polhemus, ME Fukuda, M Pichyangkul, A Gettyacamin, M Garcon, N Tucker, K Wittes, J Plowe, CV Thera, MA Duombo, OK Pau, MG Goudsmit, J Ballou, WR Cohen, J AF Heppner, DG Kester, KE Ockenhouse, CF Tornieporth, N Ofori, O Lyon, JA Stewart, VA Dubois, P Lanar, DE Krzych, U Moris, P Angov, E Cummings, JF Leach, A Hall, BT Dutta, S Schwenk, R Hillier, C Barbosa, A Ware, LA Nair, L Darko, CA Withers, MR Ogutu, B Polhemus, ME Fukuda, M Pichyangkul, A Gettyacamin, M Garcon, N Tucker, K Wittes, J Plowe, CV Thera, MA Duombo, OK Pau, MG Goudsmit, J Ballou, WR Cohen, J TI Towards an RTS,S-based, multi-stage, multi-antigen falciparum malaria: progress at the Walter Reed Army Institute of Research SO VACCINE LA English DT Article; Proceedings Paper CT 4th World Congress on Vaccines and Immunisation (WCVI) CY SEP 30-OCT 03, 2004 CL Tokyo, JAPAN SP Infect Control World Org, Minist Hlth, Labour Welfare, Minist Educ, Sci & Technol ID APICAL MEMBRANE ANTIGEN-1; B SURFACE-ANTIGEN; CIRCUMSPOROZOITE PROTEIN VACCINE; BLOOD-STAGE MALARIA; C-TERMINAL FRAGMENT; PLASMODIUM-FALCIPARUM; RECOMBINANT ADENOVIRUS; SPOROZOITE VACCINE; ESCHERICHIA-COLI; T-CELLS AB The goal of the Malaria Vaccine Program at the Walter Reed Army Institute of Research (WRAIR) is to develop a licensed multi-antigen, multi-stage vaccine against Plasmodium falciparum able to prevent all symptomatic manifestations of malaria by preventing parasitemia. A secondary goal is to limit disease in vaccinees that do develop malaria. Malaria prevention will be achieved by inducing humoral and cellular immunity against the pre-erythrocytic circumsporozoite protein (CSP) and the liver stage antigen-1 (LSA-1). The strategy to limit disease will target immune responses against one or more blood stage antigens, merozoite surface protein-1 (MSP-1) and apical merozoite antigen-1 (AMA-1). The induction of T- and B-cell memory to achieve a sustained vaccine response may additionally require immunization with an adenovirus vector such as adenovirus serotype 35. RTS,S, a CSP-derived antigen developed by GlaxoSmithKIine Biologicals in collaboration with the Walter Reed Army Institute of Research over the past 17 years, is the cornerstone of our program. RTS,S formulated in AS02A (a GSK proprietary formulation) is the only vaccine candidate shown in field trials to prevent malaria and, in one instance, to limit disease severity. Our vaccine development plan requires proof of an individual antigen's efficacy in a Phase 2 laboratory challenge or field trial prior to its integration into an RTS,S-based, multi-antigen vaccine. Progress has been accelerated through extensive partnerships with industrial, academic, governmental, and non-governmental organizations. Recent safety, immunogenicity, and efficacy trials in the US and Africa are presented, as well as plans for the development of a multi-antigen vaccine. (c) 2005 Published by Elsevier Ltd. C1 Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. GlaxoSmithKline Biol SA, Rixensart, Belgium. USA, Med Res Unit Kenya, Kenya Med Res Inst, Nairobi, Kenya. USA, Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. US Agcy Int Dev, Washington, DC 20523 USA. PATH, Malaria Vaccine Initiat, Bethesda, MD USA. Stat Collaborat Inc, Washington, DC USA. Univ Maryland, Ctr Vaccine Dev, Baltimore, MD 21201 USA. Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali. Crucell Holland BV, Leiden, Netherlands. RP Heppner, DG (reprint author), Walter Reed Army Inst Res, Dept Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM donald.heppner@na.amedd.army.mil RI Kester, Kent/A-2114-2011; Lanar, David/B-3560-2011; OI Kester, Kent/0000-0002-5056-0802; Barbosa, Arnoldo/0000-0001-8652-7396 NR 61 TC 115 Z9 117 U1 2 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 18 PY 2005 VL 23 IS 17-18 BP 2243 EP 2250 DI 10.1016/j.vaccine.2005.01.042 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 909ZH UT WOS:000227898700042 PM 15755604 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of cyanogen fluoride hydrofluoride SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; cyanogen fluoride hydrofluoride ID GAS-PHASE; INFRARED-SPECTRA; SPECTROSCOPY; COMPLEXES; HF; MATRIX; HCN AB The vibrational frequencies and corresponding normal mode assignments of cyanogen fluoride hydrofluoride are examined theoretically using the GAUSSIAN 03 set of quantum chemistry codes. All normal modes were successfully assigned (H-F stretch, F-C&3bond; N symmetric stretch, F-C&3bond; N asymmetric stretch, F-C&3bond; N bend, F-H wag, (NH)-H-... stretch, and (NH)-H-...-F bend) utilizing the C-infinity nu symmetry of the molecule. Calculated infrared intensities and Raman activities are reported. The molecular orbitals and bonding of cyanogen fluoride hydrofluoride are examined. (c) 2004 Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSRD,ECB, RT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD,ECB, RT,DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 15 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD MAR 17 PY 2005 VL 717 IS 1-3 BP 157 EP 161 DI 10.1016/j.theochem.2004.10.076 PG 5 WC Chemistry, Physical SC Chemistry GA 911SL UT WOS:000228024900022 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of trimethylsilylcyanide SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; trimethylsilylcyanide; cyanotrimethylsilane; trimethylcyanosilane; trimethylsilyl nitrile; trimethylsilylcarbonitrile ID CYANIDE; (CH3)3SICN; ISOCYANIDE; SPECTRA AB The normal mode frequencies and corresponding vibrational assignments of trimethylsilylcyanide are examined theoretically using the GAUSSIAN 98 set of quantum chemistry codes. All normal modes were successfully assigned to one of eight types of motion (Si-C stretch, C&3bond; N stretch, C-H stretch, C-Si-C bend, Si-C&3bond; N bend, H-C-H bend, CH3 rock, and CH3 twist) utilizing the C-3 nu symmetry of the molecule. Calculations were performed at the Hartree-Fock, DFT (B3LYP), and MP2 levels of theory using the standard 6-311G** basis. Theoretical results were successfully compared against available experimental data. (c) Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSRD,ECB, RT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD,ECB, RT,DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 27 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD MAR 17 PY 2005 VL 717 IS 1-3 BP 163 EP 169 DI 10.1016/j.theochem.2004.10.078 PG 7 WC Chemistry, Physical SC Chemistry GA 911SL UT WOS:000228024900023 ER PT J AU Bansal, D Cassel, F Croce, F Hendrickson, M Plichta, E Salomon, M AF Bansal, D Cassel, F Croce, F Hendrickson, M Plichta, E Salomon, M TI Conductivities and transport properties of gelled electrolytes with and without an ionic liquid for Li and Li-ion batteries SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID POLYMER ELECTROLYTES; CELLS AB Conductivity and transport properties have been determined for gelled polymer electrolytes of three compositions: a base PVdF-polymer gel with organic carbonate solvents as plasticizers and LiN(SO2C2F5)(2) electrolyte, a second polymer electrolyte with 5 mass % 1-ethyl-3-methylimidazolium bisperfluoroethylsulfonyl imide (EMI-BETI) added to the base polymer electrolyte, and a third PVdF polymer electrolyte using only EMI-BETI as the plasticizer. Conductivities were studied over the temperature range +25 to -40 degrees C, and for all three gels, the temperature dependence of the conductivities was found to follow the VTF equation, which is consistent with the free volume model for ion transport. For the gel containing 5 mass % EMI-BETI, transport numbers were determined from +50 to -20 degrees C and were found to decrease as the temperature decreased. Although there are no theoretical models to treat and interpret the temperature dependence of transport numbers, we found that a modified VTF equation resulted in an excellent fit to the temperature dependence of the transport number, which is another confirmation of a free volume model for transport in these gelled polymer electrolytes. C1 MaxPower Inc, Harleysville, PA 19483 USA. Univ G DAnnunzio, Dip Sci Farmaco, I-66013 Chieti, Italy. USA, Army Power Div, CERDEC, Ft Monmouth, NJ 07703 USA. RP Salomon, M (reprint author), MaxPower Inc, 141 Christopher Lane, Harleysville, PA 19483 USA. RI Croce, Fausto/J-8193-2012 NR 18 TC 68 Z9 70 U1 4 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD MAR 17 PY 2005 VL 109 IS 10 BP 4492 EP 4496 DI 10.1021/jp0443963 PG 5 WC Chemistry, Physical SC Chemistry GA 906GV UT WOS:000227629700031 PM 16851523 ER PT J AU Wosnick, JH Mello, CM Swager, TM AF Wosnick, JH Mello, CM Swager, TM TI Synthesis and application of poly(phenylene ethynylene)s for bioconjugation: A conjugated polymer-based fluorogenic probe for proteases SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID MOLECULAR WIRE APPROACH; DNA HYBRIDIZATION; CHEMICAL SENSORS; IONIC STRENGTH; NUCLEIC-ACIDS; POLYELECTROLYTES; PHOTOPHYSICS; PEPTIDES; DESIGN; FILMS AB A set of carboxylate-functionalized poly(phenylene ethynylene)s (PPEs) has been synthesized in which the carboxylic acid groups are separated from the polymer backbone by oligo(ethylene glycol) spacer units. These polymers are soluble in water and organic solvents and have photophysical properties that are sensitive to solvent conditions, with high salt content and the absence of surfactant promoting the formation of aggregates of relatively low quantum yield and long fluorescence lifetime. Quenching of these materials by the dinitrophenyl (DNP) chromophore (K-SV similar to 10(4)) is also highly solvent-dependent. The presence of carboxylate groups far from the polymer backbone appended to each repeating unit allows for the postpolymerization modification of these PPEs with peptides by methods analogous to those described for carboxylate-functionalized small-molecule dyes. Covalent attachment of the fluorescence-quenching 14-mer Lys(DNP)-GPLGMRGLGGGGK to the PPE results in a nonemissive substrate whose fluorescence is restored upon treatment with trypsin. The rate of fluorescence turn-on in this case is increased 3-fold by the presence of surfactant, though the actual rate of peptide hydrolysis remains the same. A small-molecule mimic of the polymer-peptide system shows a smaller fluorescence enhancement upon treatment with trypsin, illustrating the value of polymer-based amplification in this sensory scheme. C1 MIT, Dept Chem, Cambridge, MA 02139 USA. MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. USA, Dev & Engn Command, Natick Soldier Ctr, Natick, MA 01760 USA. RP Swager, TM (reprint author), MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM tswager@mit.edu RI Swager, Timothy/H-7459-2012 OI Swager, Timothy/0000-0002-3577-0510 NR 41 TC 210 Z9 211 U1 7 U2 81 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD MAR 16 PY 2005 VL 127 IS 10 BP 3400 EP 3405 DI 10.1021/ja043134b PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA 906GD UT WOS:000227627800045 PM 15755158 ER PT J AU Lilly, CM Tateno, H Oguma, T Israel, E Sonna, LA AF Lilly, CM Tateno, H Oguma, T Israel, E Sonna, LA TI Effects of allergen challenge on airway epithelial cell gene expression SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE asthma; genomics; lung disease; segmental allergen challenge ID DNA MICROARRAY ANALYSIS; ATOPIC ASTHMA; RECEPTOR; HEAT; HYPERREACTIVITY; INTERLEUKIN-13; PROGRAMS; HYPOXIA; RELEASE; INJURY AB Allergen exposure induces the airway epithelium to produce chemo-attractants, proallergic interieukins, matrix-modifying proteins, and proteins that influence the growth and activation state of airway structural cells. These proteins, in turn, contribute to the influx of inflammatory cells and changes in structure that characterize the asthmatic airway. To use the response of the airway epithelium to allergen to identify genes not previously associated with allergic responses, we compared gene expression in cytokeratin-positive cells before and after segmental allergen challenge. After challenge with concentrations of allergen in the clinically relevant range, 755 (6%) of the detectable sequences had geometric mean fold-changes in expression, with 95% confidence intervals that excluded unity. Using a prospectively defined conservative filtering algorithm, we identified 141 sequences as upregulated and eight as downregulated, with confirmation by conventional polymerase chain reaction in all 10 sequences studied. Using this approach, we identified asthma-associated sequences including interieukin (IL-)-3, IL-4, and IL-5 receptor subunits, the p65 component of nuclear factor-kappa B, and lipocortin. The genomic response of the human airway to concentrations of allergen in the clinically relevant range involves a greater number of genes than previously recognized, including many not previously associated with asthma that are differentially expressed after airway allergen exposure. C1 Brigham & Womens Hosp, Div Pulm & Crit Care, Combined Program Pulm & Crit Care Med, Boston, MA 02115 USA. Harvard Univ, Sch Med, Boston, MA USA. USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. Keio Univ, Sch Med, Dept Med, Cardiopulm Div, Tokyo 160, Japan. RP Lilly, CM (reprint author), Brigham & Womens Hosp, Div Pulm & Crit Care, Combined Program Pulm & Crit Care Med, 75 Francis St,Thorn 826C, Boston, MA 02115 USA. EM clilly@partners.org FU NHLBI NIH HHS [HL 63222] NR 40 TC 35 Z9 38 U1 0 U2 1 PU AMER THORACIC SOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD MAR 15 PY 2005 VL 171 IS 6 BP 579 EP 586 DI 10.1164/rccm.200404-532C PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 905HV UT WOS:000227560100007 PM 15618462 ER PT J AU Chiroux, RC Foster, WA Johnson, CE Shoop, SA Raper, RL AF Chiroux, RC Foster, WA Johnson, CE Shoop, SA Raper, RL TI Three-dimensional finite element analysis of soil interaction with a rigid wheel SO APPLIED MATHEMATICS AND COMPUTATION LA English DT Article ID COMPACTION C1 Auburn Univ, Dept Aerosp Engn, Auburn, AL 36849 USA. Auburn Univ, Dept Agr Engn, Auburn, AL 36849 USA. Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Natl Soils Dynam Lab, Auburn, AL 36830 USA. RP Foster, WA (reprint author), Auburn Univ, Dept Aerosp Engn, Auburn, AL 36849 USA. EM wfoster@eng.auburn.edu NR 8 TC 20 Z9 25 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0096-3003 J9 APPL MATH COMPUT JI Appl. Math. Comput. PD MAR 15 PY 2005 VL 162 IS 2 BP 707 EP 722 DI 10.1016/j.amc.2004.01.013 PG 16 WC Mathematics, Applied SC Mathematics GA 895KK UT WOS:000226860000015 ER PT J AU Schmidt, JJ Stafford, RG AF Schmidt, JJ Stafford, RG TI Botulinum neurotoxin serotype F: Identification of substrate recognition requirements and development of inhibitors with low nanomolar affinity SO BIOCHEMISTRY LA English DT Article ID PROTEOLYTIC ACTIVITY; CRYSTAL-STRUCTURE; MEMBRANE-PROTEIN; TETANUS TOXIN; B NEUROTOXIN; LIGHT-CHAIN; IN-VITRO; METALLOPROTEASE; CLEAVAGE; BINDING AB Botulinum neurotoxins (BoNTs A-G) are zinc metalloendoproteases that exhibit extraordinary specificities for proteins involved in neurotransmitter release. In view of the extreme toxicities of these molecules, their applications in human medicine, and potential for misuse, it is of considerable importance to elucidate the mechanisms underlying substrate recognition and to develop inhibitors, with the ultimate goal of obtaining anti-botulinum drugs. We synthesized peptides based on vesicle-associated membrane protein (VAMP) to investigate the substrate requirements of BoNT F, which cleaves VAMP between residues Q58 and K59. The minimum substrate was a peptide containing VAMP residues 32-65, which includes only one of the two VAMP structural motifs thought to be required for botulinum substrate recognition. BoNT F exhibited a strict requirement for residues D57 (P-2), K59 (P-1'), and L60 (P-2'), but peptides containing substitutions for R56 (P-3) Q58 (P-1), and S61 (P-3') were cleaved. Therefore, the P2, P-1', and P-2' residues of VAMP are of paramount importance for BoNT F substrate recognition near the scissile bond. K-i values of uncleavable analogues were similar to K,,, values of the substrate, suggesting that substrate discrimination occurs at the cleavage step, not at the initial binding step. We then synthesized inhibitors of BoNT F that incorporated D-cysteine in place of glutamine 58, exhibited Ki values of 1-2 nM, and required binding groups on the N-terminal but not the C-terminal side of the zinc ligand. The latter characteristic distinguishes BoNT F from other zinc metalloendoproteases, including BoNTs A and B. C1 USA, Med Res Inst Infect Dis, Div Toxicol, Ft Detrick, MD 21702 USA. RP Schmidt, JJ (reprint author), USA, Med Res Inst Infect Dis, Div Toxicol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM james.schmidt@det.amedd.army.mil NR 55 TC 41 Z9 41 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD MAR 15 PY 2005 VL 44 IS 10 BP 4067 EP 4073 DI 10.1021/bi0477642 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 906GR UT WOS:000227629300042 PM 15751983 ER PT J AU Ross, EW Taub, IA Doona, CJ Feeherry, FE Kustin, K AF Ross, EW Taub, IA Doona, CJ Feeherry, FE Kustin, K TI The mathematical properties of the quasi-chemical model for microorganism growth-death kinetics in foods SO INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY LA English DT Article DE predictive food microbiology; quasi-chemical model; chemical kinetics; differential equation system; staphylococcus aureus; Escherichia coli; hurdles; high pressure processing ID BACTERIAL-GROWTH; YERSINIA-ENTEROCOLITICA; STAPHYLOCOCCUS-AUREUS; MICROBIAL-GROWTH; SURVIVAL; SYSTEM; BREAD; YEAST AB Knowledge of the mathematical properties of the quasi-chemical model [Taub, Feeherry, Ross, Kustin, Doona, 2003. A quasi-chemical kinetics model for the growth and death of Staphylococcus aureus in intermediate moisture bread. J. Food Sci. 68 (8), 2530-2537], which is used to characterize and predict microbial growth-death kinetics in foods, is important for its applications in predictive microbiology. The model consists of a system of four ordinary differential equations (ODEs), which govern the temporal dependence of the bacterial life cycle (the lag, exponential growth, stationary, and death phases, respectively). The ODE system derives from a hypothetical four-step reaction scheme that postulates the activity of a critical intermediate as an antagonist to growth (perhaps through a quorum sensing biomechanism). The general behavior of the solutions to the ODEs is illustrated by several examples. In instances when explicit mathematical solutions to these ODEs are not obtainable, mathematical approximations are used to find solutions that are helpful in evaluating growth in the early stages and again near the end of the process. Useful solutions for the ODE system are also obtained in the case where the rate of antagonist formation is small. The examples and the approximate solutions provide guidance in the parameter estimation that must be done when fitting the model to data. The general behavior of the solutions is illustrated by examples, and the MATLAB programs with worked examples are included in the appendices for use by predictive microbiologists for data collected independently. (C) 2004 Elsevier B.V. All rights reserved. C1 USA, RDECOM, Natick Soldier Ctr, Combat Feeding Directorate, Natick, MA 01760 USA. RP Doona, CJ (reprint author), USA, RDECOM, Natick Soldier Ctr, Combat Feeding Directorate, Kansas St, Natick, MA 01760 USA. EM christopher.doona@natick.army.mil NR 32 TC 32 Z9 33 U1 3 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1605 J9 INT J FOOD MICROBIOL JI Int. J. Food Microbiol. PD MAR 15 PY 2005 VL 99 IS 2 BP 157 EP 171 DI 10.1016/j.ijfoodmicro.2004.07.019 PG 15 WC Food Science & Technology; Microbiology SC Food Science & Technology; Microbiology GA 904ZD UT WOS:000227536200005 PM 15734564 ER PT J AU Gruber, JB Nijjar, AS Sardar, DK Yow, RM Russell, CC Allik, TH Zandi, B AF Gruber, JB Nijjar, AS Sardar, DK Yow, RM Russell, CC Allik, TH Zandi, B TI Spectral analysis and energy-level structure of Er3+(4f(11)) in polycrystalline ceramic garnet Y3Al5O12 SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ND-YAG CERAMICS; LASER-EMISSION; OPTICAL-PROPERTIES; CRYSTALS; PUMP AB Absorption spectra obtained between 1550 and 440 nm and fluorescence spectra obtained between 1700 and 1500 nm are reported in a comparative spectroscopic study of polycrystalline ceramic Y3Al5O12 (YAG) and single-crystal laser rod YAG, both containing 50 at.% Er3+ as a dopant in the garnet host. The spectra are observed in both samples at temperatures between 8 K and room temperature. The detailed splitting of individual multiplet manifolds, L-2S+1(J), Er3+(4f(11)), by the crystalline electric field is similar in both the ceramic sample and the single-crystal laser rod. With few exceptions, there is little shift in energy (few wave numbers) of individual Stark levels within a manifold, between dilute and concentrated Er3+ samples. This is not too surprising since Y3Al5O12 and Er3Al5O12 form a solid solution with the majority of Er3+ ions occupying cation sites having D-2 symmetry in the garnet lattice over the entire solid solution range. As a check on the observed manifold splittings of Er3+ in ceramic YAG, we compared the present results to the calculated splitting that several of us reported earlier for Er3+ in single-crystal YAG. To within the standard deviation reported earlier, the present results agree with that calculation. Thus, one set of atomic and crystal-field parameters describes the splitting of the Er3+ energy levels in either the ceramic or single-crystal host for Er3+ in D-2 sites. (C) 2005 American Institute of Physics. C1 San Jose State Univ, Dept Phys, San Jose, CA 95192 USA. Univ Texas, Dept Phys & Astron, San Antonio, TX 78249 USA. Sci Applicat Int Corp, Ft Belvoir, VA 22060 USA. Adelphi Lab Ctr, Army Res Labs ARL, Adelphi, MD 20783 USA. RP Gruber, JB (reprint author), San Jose State Univ, Dept Phys, San Jose, CA 95192 USA. EM jbgruber@email.sjsu.edu NR 22 TC 17 Z9 17 U1 1 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 15 PY 2005 VL 97 IS 6 AR 063519 DI 10.1063/1.1861148 PG 8 WC Physics, Applied SC Physics GA 908DO UT WOS:000227767700029 ER PT J AU Burgess, EB AF Burgess, EB TI Lightning strike: The secret mission to kill admiral Yamamoto and avenge Pearl Harbor SO LIBRARY JOURNAL LA English DT Book Review C1 Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 15 PY 2005 VL 130 IS 5 BP 95 EP 96 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 905OL UT WOS:000227578300142 ER PT J AU Grujicic, M Chittajallu, KM Cao, G Roy, WN AF Grujicic, M Chittajallu, KM Cao, G Roy, WN TI An atomic level analysis of conductivity and strength in poly(ethylene oxide) sulfonic acid-based solid polymer electrolytes SO MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY LA English DT Article DE solid polymer electrolytes; ionic conductivity ID MOLECULAR-DYNAMICS SIMULATION; POLYELECTROLYTE SYSTEM; ION-CONDUCTIVITY; WATER; MEMBRANES; PROTON AB The structure, ionic conductivity and strength of poly(ethylene oxide) (PEO) sulfonic acid-based solid polymer electrolytes with various contents of the PEO polymer are analyzed using molecular dynamics simulations. To quantify the electrolyte structure, comprehensive coordination and dimensional analyses are carried out. Ionic conductivity is determined by computing,the Einstein-diffusion based conductivity for all ionic particles in the system. The strength of the electrolyte is quantified by carrying out a set of molecular simulations of the uniaxial deformation process under constant stress-rate conditions. The results obtained indicate that increased hydration improves the ionic conductivity, but degrades the strength in solid polymer electrolytes at hand. In addition, it appears that there is an optimal level of the PEO polymer content in these materials, which at the same hydration level, yields the best combination of ionic conductivity and strength. (C) 2004 Elsevier B.V. All rights reserved. C1 Clemson Univ, Dept Mech Engn, Program Mat Sci & Engn, Clemson, SC 29634 USA. USA, Res Lab, Proc & Properties Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Program Mat Sci & Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu RI Cao, guoxin/A-9790-2012 OI Cao, guoxin/0000-0002-6598-2899 NR 25 TC 7 Z9 7 U1 0 U2 7 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5107 J9 MAT SCI ENG B-SOLID JI Mater. Sci. Eng. B-Solid State Mater. Adv. Technol. PD MAR 15 PY 2005 VL 117 IS 2 BP 187 EP 197 DI 10.1016/j.mseb.2004.11.024 PG 11 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA 903TF UT WOS:000227447800015 ER PT J AU Ulrich, RL Amemiya, K Waag, DM Roy, CJ DeShazer, D AF Ulrich, RL Amemiya, K Waag, DM Roy, CJ DeShazer, D TI Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice SO VACCINE LA English DT Article DE glanders; vaccine; allelic exchange ID GRAM-NEGATIVE BACTERIA; MURINE MODEL; BALB/C MICE; MOUSE; IMMUNIZATION; IDENTIFICATION; PSEUDOMALLEI; MELIOIDOSIS; MUTAGENESIS; TULAREMIA AB Burkholderia mallei is an obligate mammalian pathogen that causes the zoonotic disease glanders. Two live attenuated B. mallei strains, a capsule mutant and a branched-chain amino acid auxotroph, were evaluated for use as vaccines against aerosol-initiated glanders in mice. Animals were aerogenically vaccinated and serum samples were obtained before aerosol challenge with a high-dose (> 300 times the LD50) of B. mallei ATCC 23344. Mice vaccinated with the capsule mutant developed a Th2-like Ig subclass antibody response and none survived beyond 5 days. In comparison, the auxotrophic mutant elicited a Th1-like Ig subclass antibody response and 25% of the animals survived for I month postchallenge. After a low-dose (5 times the LD50) aerosol challenge, the survival rates of auxotroph-vaccinated and unvaccinated animals were 50 and 0%, respectively. Thus, live attenuated strains that promote a Th1-like Ig response may serve as promising vaccine candidates against aerosol infection with B. mallei. (c) 2004 Elsevier Ltd. All rights reserved. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. RP DeShazer, D (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM david.deshazer@amedd.army.mil NR 36 TC 36 Z9 36 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 14 PY 2005 VL 23 IS 16 BP 1986 EP 1992 DI 10.1016/j.vaccine.2004.10.017 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 908EI UT WOS:000227769800013 PM 15734072 ER PT J AU Bare, EA Watts, RE Bays, JT Butkus, MA Labare, MP AF Bare, EA Watts, RE Bays, JT Butkus, MA Labare, MP TI Effects of elevated carbon dioxide levels on a marine bacterium. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 229th National Meeting of the American-Chemical-Society CY MAR 13-17, 2005 CL San Diego, CA SP Amer Chem Soc C1 US Mil Acad, Dept Chem & Life Sci, W Point, NY 10996 USA. US Mil Acad, Dept Geog & Environm Engn, W Point, NY 10996 USA. EM mm7983@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 13 PY 2005 VL 229 MA 962-CHED BP U505 EP U505 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 913TZ UT WOS:000228177703381 ER PT J AU Bays, JT Andresen, DW April, MD Daula, JW Topper, ME Petteys, R AF Bays, JT Andresen, DW April, MD Daula, JW Topper, ME Petteys, R TI Quaternary ionic liquids for matrix isolation photochemistry. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 229th National Meeting of the American-Chemical-Society CY MAR 13-17, 2005 CL San Diego, CA SP Amer Chem Soc C1 US Mil Acad, Dept Chem & Life Sci, W Point, NY 10996 USA. Univ S Florida, Dept Chem, Tampa, FL 33620 USA. EM tim-bays@usma.edu; Michael.April@usma.edu; John.Daula@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 13 PY 2005 VL 229 MA 208-INOR BP U992 EP U992 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 913TZ UT WOS:000228177707207 ER PT J AU Bjerke, AE Cody, JR Sasso, AR AF Bjerke, AE Cody, JR Sasso, AR TI Multicomponent analysis of photodecomposition products of chemical sunscreen agent/antioxidant mixtures SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 229th National Meeting of the American-Chemical-Society CY MAR 13-17, 2005 CL San Diego, CA SP Amer Chem Soc C1 US Mil Acad, Dept Chem & Life Sci, W Point, NY 10996 USA. EM ma4906@usma.edu; John.Cody@exmail.usma.edu; adam.sasso@exmail.usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 13 PY 2005 VL 229 MA 344-CHED BP U392 EP U392 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 913TZ UT WOS:000228177702370 ER PT J AU Dengler, BA Labare, MP AF Dengler, BA Labare, MP TI Amine release from sulfonic acids: Degradation of VX by taurine-utilizing bacteria SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 229th National Meeting of the American-Chemical-Society CY MAR 13-17, 2005 CL San Diego, CA SP Amer Chem Soc C1 US Mil Acad, Dept Chem & Life Sci, W Point, NY 10996 USA. EM mm7983@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 13 PY 2005 VL 229 MA 753-CHED BP U473 EP U473 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 913TZ UT WOS:000228177703176 ER PT J AU Gu, ZF Januszkiewicz, AJ AF Gu, ZF Januszkiewicz, AJ TI Acute pulmonary ventilation injury caused by brief exposure to nitrogen dioxide in awake rats. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 229th National Meeting of the American-Chemical-Society CY MAR 13-17, 2005 CL San Diego, CA SP Amer Chem Soc C1 Walter Reed Army Inst Res, Dept Resp Res, Silver Spring, MD 20910 USA. EM zengfa.gu@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 13 PY 2005 VL 229 MA 291-INOR BP U1006 EP U1006 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 913TZ UT WOS:000228177707290 ER PT J AU Hsu, FL Winemiller, MD Berg, FJ Rastogi, NK Cheng, TC AF Hsu, FL Winemiller, MD Berg, FJ Rastogi, NK Cheng, TC TI 3-indolyl methylphosphonate and methylphosphonothioate as indicators for enzyme-based decontamination of organophosphonate agents. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 229th National Meeting of the American-Chemical-Society CY MAR 13-17, 2005 CL San Diego, CA SP Amer Chem Soc C1 USA, Edgewood Chem Biol Ctr, Dept Phys & Chem Sci, Aberdeen Proving Ground, MD 21010 USA. USA, Edgewood Chem Biol Ctr, Dept Toxicol, Aberdeen Proving Ground, MD 21010 USA. EM fulian.hsu@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 13 PY 2005 VL 229 MA 140-ORGN BP U347 EP U347 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 008UQ UT WOS:000235066601245 ER PT J AU Miroshnikova, OV Zhu, S Hudson, TH Gerena, L Lin, AJ AF Miroshnikova, OV Zhu, S Hudson, TH Gerena, L Lin, AJ TI Design, synthesis and antimalarial activity of novel peptidomimetics based on Michael acceptor core. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 229th National Meeting of the American-Chemical-Society CY MAR 13-17, 2005 CL San Diego, CA SP Amer Chem Soc C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM olga.miroshnikova@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 13 PY 2005 VL 229 MA 379-MEDI BP U176 EP U176 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 008UQ UT WOS:000235066600378 ER PT J AU Rawlett, AM Orlicki, JA Karikari, AS AF Rawlett, AM Orlicki, JA Karikari, AS TI Self assembled, ultra-hydrophobic micro/nano-textured surfaces. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 229th National Meeting of the American-Chemical-Society CY MAR 13-17, 2005 CL San Diego, CA SP Amer Chem Soc C1 USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA. EM arawlett@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 13 PY 2005 VL 229 MA 534-POLY BP U985 EP U985 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 008UQ UT WOS:000235066604531 ER PT J AU Zhang, Q Guan, J Montipa, G Ellis, WY Ager, A Milhlous, WK Skillman, DR Lin, AJ AF Zhang, Q Guan, J Montipa, G Ellis, WY Ager, A Milhlous, WK Skillman, DR Lin, AJ TI Synthesis and prophylactic antimalarial activities of 2-guanidinylimidazolidinedione derivatives. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 229th National Meeting of the American-Chemical-Society CY MAR 13-17, 2005 CL San Diego, CA SP Amer Chem Soc C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Univ Miami, Ctr Trop Parasit Dis, Coral Gables, FL USA. EM quan.zhang@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 13 PY 2005 VL 229 MA 384-MEDI BP U177 EP U177 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 008UQ UT WOS:000235066600383 ER PT J AU Ji, XJ Zheng, JY Xu, JM Rastogi, VK Cheng, TC DeFrank, JJ Leblanc, RM AF Ji, XJ Zheng, JY Xu, JM Rastogi, VK Cheng, TC DeFrank, JJ Leblanc, RM TI (CdSe)ZnS quantum dots and organophosphorus hydrolase bioconjugate as biosensors for detection of paraoxon SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID PROTEIN SECONDARY STRUCTURE; RESONANCE ENERGY-TRANSFER; PSEUDOMONAS-DIMINUTA; CIRCULAR-DICHROISM; NERVE AGENTS; GLOBULAR-PROTEINS; CDS NANOCRYSTALS; PHOSPHOTRIESTERASE; TEMPERATURE; CDTE AB In this paper, we first report a novel biosensor for the detection of paraoxon based on (CdSe)ZnS core-shell quantum dots (QDs) and an organophosphorus hydrolase (OPH) bioconjugate. The OPH was coupled to (CdSe)ZnS core-shell QDs through electrostatic interaction between negatively charged QDs surfaces and the positively charged protein side chain and ending groups (-NH2). Circular dichroism (CD) spectroscopy showed no significant change in the secondary structure of OPH after the bioconjugation, which indicates that the activity of OPH was preserved. Detectable secondary structure changes were observed by CD spectroscopy when the OPH/QDs bioconjugate was exposed to organophosphorus compounds such as paraoxon. Photoluminescence (PL) spectroscopic study showed that the PL intensity of the OPH/QDs bioconjugate was quenched in the presence of paraoxon. The overall quenching percentage as a function of paraoxon concentration matched very well with the Michaelis -Menten equation. This result indicated that the quenching of PL intensity was caused by the conformational change in the enzyme, which is confirmed by CD measurements. The detection limit of paraoxon concentration using OPH/QDs bioconjugate was about 10(-8) M. Although increasing the OPH molar ratio in the bioconjugates will slightly increase the sensitivity of biosensor, no further increase of sensitivity was achieved when the molar ratio of OPH to QDs was greater than 20 because the surface of QDs was saturated by OPH. These properties make the OPH/QDs bioconjugate a promising biosensor for the detection of organ opho sphorus compounds. C1 Univ Miami, Dept Chem, Coral Gables, FL 33124 USA. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. Geocenters Inc, Gunpowder Club, Aberdeen Proving Ground, MD 21010 USA. RP Leblanc, RM (reprint author), Univ Miami, Dept Chem, Coral Gables, FL 33124 USA. EM rm1@miami.edu NR 57 TC 170 Z9 188 U1 3 U2 40 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD MAR 10 PY 2005 VL 109 IS 9 BP 3793 EP 3799 DI 10.1021/jp044928f PG 7 WC Chemistry, Physical SC Chemistry GA 904ER UT WOS:000227479400018 PM 16851427 ER PT J AU Kim, M Nagarajan, R Snook, JH Samuelson, LA Kumar, J AF Kim, M Nagarajan, R Snook, JH Samuelson, LA Kumar, J TI Nanostructured assembly of homopolymers for a flexible Bragg grating SO ADVANCED MATERIALS LA English DT Article ID POLYELECTROLYTE MULTILAYERS AB Fabrication of homogeneous, flexible, polymeric, dielectric Bragg gratings is demonstrated. The Bragg grating is assembled on a poly(ethylene terephthalate) film using polymeric colloidal microspheres of polystyrene (PS) and poly(methyl methacrylate) (PMMA) (see Figure). The microspheres are stacked successively with precise control at the nanometer scale and the gratings, free of metal and inorganic materials, cover a relatively large area. C1 Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. USA, RDECOM, Natick Soldier Ctr, Natick, MA 01760 USA. RP Kim, M (reprint author), Univ Massachusetts, Ctr Adv Mat, 1 Univ Ave, Lowell, MA 01854 USA. EM M_Kim@uml.edu; jayant_Kumar@uml.edu NR 10 TC 6 Z9 6 U1 0 U2 6 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0935-9648 J9 ADV MATER JI Adv. Mater. PD MAR 8 PY 2005 VL 17 IS 5 BP 631 EP + DI 10.1002/adma.200400693 PG 4 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 907ZK UT WOS:000227756600030 ER PT J AU Reed, MJ Arkun, FE Berkman, EA Elmasry, NA Zavada, J Luen, MO Reed, ML Bedair, SM AF Reed, MJ Arkun, FE Berkman, EA Elmasry, NA Zavada, J Luen, MO Reed, ML Bedair, SM TI Effect of doping on the magnetic properties of GaMnN: Fermi level engineering SO APPLIED PHYSICS LETTERS LA English DT Article ID FERROMAGNETIC PROPERTIES AB GaMnN dilute magnetic semiconductor samples, prepared by metalorganic chemical vapor deposition, are shown to exhibit ferromagnetism or even paramagnetism depending upon the type and concentration of extrinsic impurity present in the film. In addition, GaMnN deposited using growth parameters. normally yielding a nonferromagnetic film becomes strongly ferromagnetic with the addition of magnesium, an acceptor dopant. Based upon these observations, it seems that ferromagnetism in this material system depends on the relative position of the Mn energy band and the Fermi level within the GaMnN band gap. Only when the Fermi level closely coincides with the Mn-energy level is ferromagnetism achieved. By actively engineering the Fermi energy to be within or near the Mn energy band, room temperature ferromagnetism is realized. 0 2005 American Institute of Physics. C1 N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. USA, Res Off, Durham, NC 27709 USA. N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. RP Bedair, SM (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM bedair@eos.ncsu.edu RI ELMASRY, NADIA/F-9928-2012 NR 10 TC 60 Z9 65 U1 1 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 7 PY 2005 VL 86 IS 10 AR 102504 DI 10.1063/1.1881786 PG 3 WC Physics, Applied SC Physics GA 911YQ UT WOS:000228044700038 ER PT J AU Wei, Q Ramesh, KT Ma, E Kesckes, LJ Dowding, RJ Kazykhanov, VU Valiev, RZ AF Wei, Q Ramesh, KT Ma, E Kesckes, LJ Dowding, RJ Kazykhanov, VU Valiev, RZ TI Plastic flow localization in bulk-tungsten with ultrafine microstructure SO APPLIED PHYSICS LETTERS LA English DT Article ID ENERGY PENETRATOR MATERIALS; POLYCRYSTALLINE TUNGSTEN; GRAIN SIZES; SHEAR BANDS; STRAIN-RATE; DEFORMATION; NANOCRYSTALLINE; COMPRESSION; TRANSITION; BEHAVIOR AB Shear localization is demonstrated in bulk tungsten (W) of commercial purity under dynamic uniaxial compression. Microstructure refinement via severe plastic deformation was the strategy used to induce this unusual deformation mode for W. The ultrafine microstructure achieved in bcc materials leads to elevated strength and ductility, as well as reduced strain hardening and strain. rate hardening, thus enhancing the propensity for adiabatic plastic flow localization. (c) 2005 American Institute of Physics. C1 Johns Hopkins Univ, CAMCS, Baltimore, MD 21218 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Ufa State Aviat Tech Univ, Ufa 450000, Russia. RP Ma, E (reprint author), Johns Hopkins Univ, CAMCS, Baltimore, MD 21218 USA. EM ema@jhu.edu RI Wei, Qiuming/B-7579-2008; Ma, En/A-3232-2010; Dowding, Robert/F-1469-2015 OI Dowding, Robert/0000-0002-4763-2131 NR 27 TC 65 Z9 70 U1 5 U2 46 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 7 PY 2005 VL 86 IS 10 AR 101907 DI 10.1063/1.1875754 PG 3 WC Physics, Applied SC Physics GA 911YQ UT WOS:000228044700017 ER PT J AU Angelo, G Lamon-Fava, S Paulson, KE Rosenberg, I Sonna, LA Wood, RJ AF Angelo, G Lamon-Fava, S Paulson, KE Rosenberg, I Sonna, LA Wood, RJ TI RNAi-mediated knockdown of heat shock protein 90 beta (Hsp90 beta) impairs responsiveness to vitamin D in Caco-2 cells SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 Tufts Univ, USDA, Jean Mayer Human Nutr Res Ctr Aging, Boston, MA 02111 USA. USA, Environm Med Res Inst, TMD, Natick, MA 01760 USA. Tufts Univ New England Med Ctr, Dept Radiat Oncol, Boston, MA 02111 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1452 EP A1452 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610903242 ER PT J AU Bustamante, M Sjogren, MH Rojkind, M AF Bustamante, M Sjogren, MH Rojkind, M TI Development of a functional long-term co-culture of human hepatocytes and rat hepatic stellate cells SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 George Washington Univ, Med Ctr, Washington, DC 20037 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1049 EP A1049 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610900357 ER PT J AU Carter, R Cheuvront, SN Vernieuw, CR Sawka, MN AF Carter, R Cheuvront, SN Vernieuw, CR Sawka, MN TI Cerebral blood flow velocity and blood pressure responses to standing after passive dehydration heat stress SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1192 EP A1192 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610901350 ER PT J AU Chambers, C Liu, WY Lu, CY Naik, R Doctor, BP Saxena, A AF Chambers, C Liu, WY Lu, CY Naik, R Doctor, BP Saxena, A TI Epitope mapping of monoclonal antibodies to fetal bovine serum acetylcholinesterase SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1400 EP A1400 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610902666 ER PT J AU Dubick, MA Cameron, DG Prince, MD Sondeen, JL AF Dubick, MA Cameron, DG Prince, MD Sondeen, JL TI Indices of tissue injury and oxidative stress in conscious, sedated swine subjected to severe hemorrhage and hypotensive resuscitation SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1221 EP A1221 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610901486 ER PT J AU Haigh, JR Gordon, RK Johnston, SR Garcia, GE Doctor, BP Riel, MA Lenz, DE Aisen, PS AF Haigh, JR Gordon, RK Johnston, SR Garcia, GE Doctor, BP Riel, MA Lenz, DE Aisen, PS TI Inhibition of cholinesterases (ChE) by pyridostigmine bromide (PB) and (-) huperzine A (HUP) in whole human blood and protection of organophosphate poisoning SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. Georgetown Univ, Med Ctr, Washington, DC 20007 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1079 EP A1079 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610900497 ER PT J AU Jennings, AM Merritt, E Walters, T Farrar, R AF Jennings, AM Merritt, E Walters, T Farrar, R TI Functional and histological assessment of skeletal muscle after 2, 2.5, 3, and 4 hours of tourniquet SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 Univ Texas, Austin, TX 78712 USA. USA, Inst Surg Res, Soft Tissue Injury Lab, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1124 EP A1124 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610901038 ER PT J AU Jett, M Anderson, M Yourick, DL AF Jett, M Anderson, M Yourick, DL TI Near peer mentoring: A step-wise means of engaging young students in science SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1396 EP A1396 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610902647 ER PT J AU Leon, LR Blaha, M AF Leon, LR Blaha, M TI Plasma cytokine response during heat strain recovery in mice SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1192 EP A1192 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610901349 ER PT J AU Mani, S Coleman, GD Bi, SG Das, R Jett, M AF Mani, S Coleman, GD Bi, SG Das, R Jett, M TI Stage appropriate therapies for Staphylococcal Enterotoxin B (SEB) induced lethal shock SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1226 EP A1226 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610901506 ER PT J AU Martini, WZ Chinkes, DL Pusateri, AE Holcomb, JB Yu, YM Wolfe, RR AF Martini, WZ Chinkes, DL Pusateri, AE Holcomb, JB Yu, YM Wolfe, RR TI Acute changes in fibrinogen metabolism and coagulation after hemorrhage in pigs SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas, Med Branch, Galveston, TX 77550 USA. Harvard Univ, Sch Med, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1470 EP A1470 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610903325 ER PT J AU Ryan, KL Cortez, DS Dick, EJ AF Ryan, KL Cortez, DS Dick, EJ TI Do FDA-approved intravenous hemostatic agents, when used in combination, reduce blood loss in rat models of uncontrolled hemorrhage? SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1221 EP A1221 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610901485 ER PT J AU Stephenson, LA Leammukda, W Cadarette, B Kolka, MA AF Stephenson, LA Leammukda, W Cadarette, B Kolka, MA TI Liquid cooling garment (LCG) pulsatile cooling improves regional skin cooling efficiency SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1193 EP A1193 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610901354 ER PT J AU Vernieuw, CR Stephenson, LA Kolka, MA AF Vernieuw, CR Stephenson, LA Kolka, MA TI Thermal comfort (TC) and sensation (TS) in exercising men wearing a liquid cooling garment (LCG): comparison of constant cooling (CC) vs. intermittent cooling (IC) SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1194 EP A1194 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610901358 ER PT J AU Wang, XY Bynum, J Stavchansky, S Bowman, P AF Wang, XY Bynum, J Stavchansky, S Bowman, P TI Comparison of the transcriptional activities of cytoprotective doses of caffeic acid phenethyl ester (CAPE), curcumin (CUC), and resveratrol (RES) against menadione toxicity in human umbilical vein endothelial cells (HUVEC) SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 Univ Texas, Austin, TX 78712 USA. USA, Inst Surg Res, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1558 EP A1558 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610904054 ER PT J AU Wang, XY Zhao, BT Bynum, J Stavchansky, S Bowman, P AF Wang, XY Zhao, BT Bynum, J Stavchansky, S Bowman, P TI Cytoprotection of human umbilical vein cells (HUVEC) against menadione toxicity by caffeic acid phenethyl ester (CAPE): role for heme oxygenase-1 (HMOX1) SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 Univ Texas, Austin, TX 78712 USA. USA, Inst Surg Res, San Antonio, TX 78234 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1554 EP A1555 PN 2 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610904038 ER PT J AU Wu, JC Coviello, LC Hashiro, GM Hernendez, CA Uyehara, CFT AF Wu, JC Coviello, LC Hashiro, GM Hernendez, CA Uyehara, CFT TI Vasopressin prevents renal shutdown via pressure diuresis in endotoxin-induced septic shock SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 3 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1582 EP A1582 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610904163 ER PT J AU Yeung, DT Josse, D Lenz, DE Cerasoli, DM AF Yeung, DT Josse, D Lenz, DE Cerasoli, DM TI Structure/function analyses of rationally designed human serum paraoxonase (HuPON1) mutants SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunologists, Amer Physiol Soc, Amer Soc Biochem & Mol Biol, Amer Soc Invest Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut, Int Union Physiol Sci C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. Univ Maryland, Baltimore, MD 21201 USA. Ctr Rech Serv Sante Armees, Dept Toxicol, F-38702 La Tronche, France. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 7 PY 2005 VL 19 IS 5 SU S BP A1079 EP A1079 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZS UT WOS:000227610900498 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of fluorine nitrate SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; fluorine nitrate; nitroxy fluoride; fluoronitrate; nitrogen oxyfluoride; nitrogen trioxyfluoride; nitryl hypofluorite ID HALOGEN NITRATES; RECOMBINATION REACTIONS; THERMAL-DISSOCIATION; MOLECULAR-STRUCTURE; INFRARED-SPECTRA; XONO2 X; CL; BR; STABILITY; AZIDE AB The vibrational frequencies and corresponding normal mode assignments of fluorine nitrate are examined theoretically using the GAUSSIAN98 set of quantum chemistry codes. All normal modes were successfully assigned to one of six types of motion (N=O stretch, N-O stretch, F-O stretch, O-F-O bend, F-O-N bend, and F-O-N-O torsion) utilizing the C, symmetry of the molecule. Uniform scaling factors were derived for each type of motion. Predicted infrared and Raman intensities are reported. Molecular orbitals and bonding are examined. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSRD,ECB, RT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD,ECB, RT,DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 41 TC 2 Z9 3 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD MAR 7 PY 2005 VL 716 IS 1-3 BP 11 EP 17 DI 10.1016/j.theochem.2004.10.041 PG 7 WC Chemistry, Physical SC Chemistry GA 910XT UT WOS:000227966200002 ER PT J AU Crenshaw, ME AF Crenshaw, ME TI Quantum electrodynamic foundations of continuum electrodynamics SO PHYSICS LETTERS A LA English DT Article AB A microscopic quantum electrodynamic model of a linear medium consisting of discrete quantized electric and magnetic dipoles is used to derive Maxwell equations of motion for macroscopic fields. It is found that the material properties of a linear medium are carried in the sum of the vacuum, electric, and magnetic susceptibilities. (C) 2005 Elsevier B.V. All rights reserved. C1 USA, RDECOM, AMSRD AMR WS ST, Redstone Arsenal, AL 35898 USA. RP Crenshaw, ME (reprint author), USA, RDECOM, AMSRD AMR WS ST, Redstone Arsenal, AL 35898 USA. EM michael.crenshaw@us.army.mil NR 10 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9601 J9 PHYS LETT A JI Phys. Lett. A PD MAR 7 PY 2005 VL 336 IS 2-3 BP 106 EP 111 DI 10.1016/j.physleta.2004.12.081 PG 6 WC Physics, Multidisciplinary SC Physics GA 900GW UT WOS:000227204400003 ER PT J AU Anderson, DR Holmes, WW AF Anderson, DR Holmes, WW TI Evaluation of Trolox as a treatment for sulfur mustard (HD)-induced lung injury in rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Med Res Inst Chem Def, Div Pharmacol, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A114 EP A114 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610700527 ER PT J AU Bhat, KR Benton, BJ Ray, R AF Bhat, KR Benton, BJ Ray, R TI Poly (ADP-ribose) polymerase (PARP) is essential for sulfur mustard-induced DNA damage repair, but has no role in DNA ligase activation SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Med Res Inst Chem Def, Dept Biochem Pharmacol, Aberdeen Proving Ground, MD 21010 USA. Lincoln Univ, Dept Chem, Lincoln, PA 19352 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A506 EP A506 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610703414 ER PT J AU Blaha, MD Leon, LR AF Blaha, MD Leon, LR TI Surgical recovery in mice is dependent on analgesic choice: Buprenorphine vs. indomethacin SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A183 EP A183 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610701208 ER PT J AU Bovill, ME Wang, MC Block, G Sabry, Z Kemmer, TM AF Bovill, ME Wang, MC Block, G Sabry, Z Kemmer, TM TI Performance of simple anthropometrics to detect cardiovascular disease (CVD) risk in children using receiver operating characteristics (ROC) curves SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. USA, Dept Med, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Ctr Disaster & Humanitar Assistance Med, Bethesda, MD 20814 USA. RI Block, Gladys/E-3304-2010 NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A65 EP A65 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610700300 ER PT J AU Bowman, P Bynum, J du Bois, M AF Bowman, P Bynum, J du Bois, M TI Lyophilized tissue embedded in polyester wax is suitable for histological evaluation and isolation of RNA SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A264 EP A264 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610701591 ER PT J AU Claybaugh, JR Lim, JM Sato, AK Bird, DN Knee, DS Uyehara, CFT AF Claybaugh, JR Lim, JM Sato, AK Bird, DN Knee, DS Uyehara, CFT TI Temporal effects of prenatal ethanol exposure on drinking behavior, vasopressin, and oxytocin in the rat SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. Univ Hawaii, Honolulu, HI 96822 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A737 EP A737 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610705231 ER PT J AU Gordon, RK Owens, RR Baker, K Askins, LY Doctor, BP Clarkson, ED Mitcheltree, LW Schutz, S Kelleher, C Washington, N Railer, R AF Gordon, RK Owens, RR Baker, K Askins, LY Doctor, BP Clarkson, ED Mitcheltree, LW Schutz, S Kelleher, C Washington, N Railer, R TI Personal decontamination and detoxification of chemical warfare agents (CWA) SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. USA, Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A489 EP A489 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610703331 ER PT J AU Gordon, RK Feaster, SR Haigh, JR Doctor, BP AF Gordon, RK Feaster, SR Haigh, JR Doctor, BP TI Robotic whole blood acetyl- and butyryl-cholinesterase assay SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A264 EP A264 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610701592 ER PT J AU Hammamieh, R Jett, M AF Hammamieh, R Jett, M TI Use of bioinformatics approaches to unambiguously identify host gene responses characteristic of exposure to biothreat agents SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A853 EP A853 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610706107 ER PT J AU Hammamieh, R Chakraborty, N Barmada, M Das, R Jett, M AF Hammamieh, R Chakraborty, N Barmada, M Das, R Jett, M TI Global gene expression analysis to study differential effects of omega-3 and omega-6 fatty acids on in MDA-MB-231 breast cancer cell line SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A284 EP A284 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702025 ER PT J AU Heinlen, LD Kim-Howard, XR McClain, MT Dennis, GJ Harley, JB James, JA AF Heinlen, LD Kim-Howard, XR McClain, MT Dennis, GJ Harley, JB James, JA TI Autoantibody concentrations increase leading up to SLE diagnosis SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK 73104 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A885 EP A885 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610706261 ER PT J AU Holmes, WW Anderson, DR AF Holmes, WW Anderson, DR TI Protective properties of Trasylol((R)) in sulfur mustard (SM)-induced lung injury SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Med Res Inst Chem Def, Div Pharmacol, Edgewood, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A114 EP A114 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610700526 ER PT J AU Ishida, H Ray, P AF Ishida, H Ray, P TI Knockdown of RhoB expression caused a total inhibition of actin reorganization and acetylcholine exocytosis in NGF-differentiated PC12 cells SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A316 EP A316 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702179 ER PT J AU Jin, XN Ray, R Ray, P AF Jin, XN Ray, R Ray, P TI Studies on mustard-stimulated proteases and inhibitors in human epidermal keratinocytes (HEK): Development of antivesicant drugs SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Dept Biol, Div Expt Therapeut, Silver Spring, MD 20910 USA. USA, Med Res Inst Chem Def, Biochem Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A863 EP A864 PN 1 PG 2 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610706159 ER PT J AU Juang, YT Wang, Y Solomou, EE Li, YS Mawrin, C Tenbrock, K Kyttaris, VC Tsokos, GC AF Juang, YT Wang, Y Solomou, EE Li, YS Mawrin, C Tenbrock, K Kyttaris, VC Tsokos, GC TI SLE serum IgG increases CREM binding to the IL-2 promoter and suppress IL-2 production through CaMKIV SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Washington Hosp Ctr, Rheumatol Sect, Washington, DC 20010 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A387 EP A387 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702506 ER PT J AU Kulik, L Fleming, SD Tsokos, GC Holers, MV AF Kulik, L Fleming, SD Tsokos, GC Holers, MV TI Differences in the diversity of murine natural antibodies to autoantigens caused by an absence of complement receptors CR1 and CR2 SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Univ Colorado, Hlth Sci Ctr, Denver, CO 80262 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A323 EP A323 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702210 ER PT J AU Mayda, ME Palmer, D Hammamieh, R Gunter, V Bisbing, J Jett, M Das, R AF Mayda, ME Palmer, D Hammamieh, R Gunter, V Bisbing, J Jett, M Das, R TI The four dengue serotypes: Similarities and differences in gene expression pattern SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A483 EP A483 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610703306 ER PT J AU McClung, JP Scrimgeour, AG Morales-Martinez, N Young, MA Leon, LR Young, AJ AF McClung, JP Scrimgeour, AG Morales-Martinez, N Young, MA Leon, LR Young, AJ TI Differential regulation of downstream targets of mTOR in response to acute heat strain in mouse skeletal muscle SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. USA, Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A625 EP A625 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610704348 ER PT J AU Merritt, E Jennings, AM Walters, T Farrar, R AF Merritt, E Jennings, AM Walters, T Farrar, R TI Effect of exercise training on recovery of skeletal muscle function following ischemia/reperfusion injury SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Univ Texas, Austin, TX 78712 USA. USA, Inst Surg Res, Soft Tissue Injury Lab, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A484 EP A484 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610703310 ER PT J AU Naik, RS Belinskaya, T Purohit, D Bansal, R Doctor, BP Saxena, A AF Naik, RS Belinskaya, T Purohit, D Bansal, R Doctor, BP Saxena, A TI Monoclonal antibodies to fetal bovine serum acetylcholinesterase distinguish cholinesterases from various animal species SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A293 EP A293 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702068 ER PT J AU Okoye, FI Tsokos, GC Farber, DL AF Okoye, FI Tsokos, GC Farber, DL TI Upregulation of the signaling subunit, FCR-f(x), uncouples T cell receptor signaling from effector function in human T cells SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Univ Maryland, Baltimore, MD 21201 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A383 EP A383 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702487 ER PT J AU Patel, P Clark, C Brecht, K Maxwell, D Lenz, D Cerasoli, D AF Patel, P Clark, C Brecht, K Maxwell, D Lenz, D Cerasoli, D TI Binding of organophosphorus compounds to sera from rats, guinea pigs, monkeys and humans SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A861 EP A861 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610706148 ER PT J AU Peachman, KK Palmer, DR Bisbing, J Sun, W Alving, CR Rao, M AF Peachman, KK Palmer, DR Bisbing, J Sun, W Alving, CR Rao, M TI Characterization of dendritic cell reactivity to dengue virus and dengue antigens SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Dept Vaccine Prod & Delivery, Rockville, MD 20850 USA. Walter Reed Army Inst Res, Dept Virus Dis, Rockville, MD 20850 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A411 EP A411 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702620 ER PT J AU Ray, P Jin, XN Ray, R AF Ray, P Jin, XN Ray, R TI Medical diagnosis of mustard gas exposure SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Walter Reed Army Inst Res, Dept Biol, Div Expt Therapeut, Silver Spring, MD 20910 USA. USA, Med Res Inst Chem Def, Div Pharmacol, Biochem Pharmacol Branch, Aberdeen Proving Ground, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A864 EP A864 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610706160 ER PT J AU Ray, R Hauck, S Kramer, R Benton, B AF Ray, R Hauck, S Kramer, R Benton, B TI A streamlined assay of apoptosis due to sulfur mustard (SM) using human epidermal keratinocytes (HEK) monolayer microplate cultures and fluorogenic caspase-3 substrates SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Med Res Inst Chem Def, Biochem Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A494 EP A494 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610703357 ER PT J AU Ronca, AE Baer, LA Wade, CE AF Ronca, AE Baer, LA Wade, CE TI Prenatal hypergravity exposure: Evidence for developmental programming SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Wake Forest Univ, Sch Med, Winston Salem, NC 27101 USA. NASA, Ames Res Ctr, Div Life Sci, Moffett Field, CA 94035 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A665 EP A665 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610704538 ER PT J AU Saikh, KU Kissner, TL Sultana, A Ruthel, G Ulrich, RG Kissner, TL AF Saikh, KU Kissner, TL Sultana, A Ruthel, G Ulrich, RG Kissner, TL TI Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A411 EP A411 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702619 ER PT J AU Scrimgeour, AG McClung, JP Condlin, ML Leon, LR Young, AJ AF Scrimgeour, AG McClung, JP Condlin, ML Leon, LR Young, AJ TI Heat strain inhibits translation initiation and elongation in the mouse SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A625 EP A625 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610704350 ER PT J AU Subudhi, AW Jacobs, KA Hagobian, TA Fattor, JA Cymerman, A Friedlander, AL AF Subudhi, AW Jacobs, KA Hagobian, TA Fattor, JA Cymerman, A Friedlander, AL TI Antioxidants affect power output at ventilatory threshold during high altitude training SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Colorado Ctr Altitude Med & Physiol, Aurora, CO 80010 USA. Orthoped Special Hosp, Salt Lake City, UT 84107 USA. VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A133 EP A133 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610700617 ER PT J AU Swietnicki, W O'Brien, S Nystrom, S Dyas, B Ruthel, G Tropea, J Waugh, D Ulrich, R AF Swietnicki, W O'Brien, S Nystrom, S Dyas, B Ruthel, G Tropea, J Waugh, D Ulrich, R TI Intra- and inter-domain interactions between Yersinia pestis virulence proteins YopB, YopD, and the chaperone SycD SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. SAIC Frederick, Frederick, MD 21702 USA. NCI Frederick, Macromol Crystallog Lab, Frederick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A314 EP A314 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702168 ER PT J AU Tenbrock, K Ahlmann, M Ehrchen, JM Viemann, D Scholzen, T Roth, J Tsokos, GC AF Tenbrock, K Ahlmann, M Ehrchen, JM Viemann, D Scholzen, T Roth, J Tsokos, GC TI CREM regulates CD86 expression SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Univ Munster, D-48149 Munster, Germany. IZKF Munster, D-48149 Munster, Germany. Walter Reed Army Inst Res, MCR, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A18 EP A18 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610700084 ER PT J AU Tou, J Brown, M Foley, A Yuan, Y Buff, P Wade, C Arnaud, S AF Tou, J Brown, M Foley, A Yuan, Y Buff, P Wade, C Arnaud, S TI Hindlimb unloading and reloading on long bones in intact versus ovariectomized rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. Univ Missouri, Ctr Gen Physiol, Columbia, MO 65211 USA. Ryerson Univ, Toronto, ON M5B 2K3, Canada. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A197 EP A197 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610701271 ER PT J AU Ulrich, RG Kissner, T Sultana, A Nystrom, S Ruthel, G Saikh, KU AF Ulrich, RG Kissner, T Sultana, A Nystrom, S Ruthel, G Saikh, KU TI Human monocyte response to intracellular infection by Yersinia pestis involves TLR9 and type I interferons but not TLR4 SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Med Res Inst Infect Dis, Lab Mol Immunol, Frederick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A369 EP A369 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610702424 ER PT J AU Uyehara, CFT Wu, JC Marean, AJ Hashiro, GM Hernandez, CA AF Uyehara, CFT Wu, JC Marean, AJ Hashiro, GM Hernandez, CA TI Enhanced vasopressin secretion is not evident in rats chronically exposed to alcohol SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A592 EP A592 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610704200 ER PT J AU Uyehara, CFT Marean, AJ Wu, J Hernandez, CA Hashiro, GM Claybaugh, JR AF Uyehara, CFT Marean, AJ Wu, J Hernandez, CA Hashiro, GM Claybaugh, JR TI Gender difference in water excretion is associated with estrous cycle phase and lower resting blood pressure in female rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Tripler Army Med Ctr, Dept Clin Invest, MCHK, CI CDR, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A579 EP A579 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610704142 ER PT J AU Wade, C Baer, L Hsu, O McCue, R AF Wade, C Baer, L Hsu, O McCue, R TI Responses to hemorrhagic hypovolemia in hindlimb suspended (HLS) rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 USA, Inst Surg Res, San Antonio, TX 78234 USA. NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A667 EP A667 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610704545 ER PT J AU Zakrzewska, EI Lintault, L Maple, R Baer, L Ronca, A Wade, C Plaut, K AF Zakrzewska, EI Lintault, L Maple, R Baer, L Ronca, A Wade, C Plaut, K TI Effects of 2 x gravity (2-g) on prolactin receptor expression in adipose tissue of periparturient rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences CY MAR 31-APR 06, 2005 CL San Diego, CA SP Amer Assoc Anatomists, Amer Assoc Immunol, Amer Phtsiol Soc & Int Union Physiol Sci, Amer Soc Biochem & Mole Biol, Amer Soc Investigat Pathol, Amer Soc Nutr Sci, Amer Soc Pharmacol & Exptl Therapeut C1 Univ Vermont, Burlington, VT 05405 USA. NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. Wake Forest Univ, Sch Med, Winston Salem, NC 27101 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78123 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 4 PY 2005 VL 19 IS 4 SU S BP A669 EP A669 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 905ZQ UT WOS:000227610704554 ER PT J AU Arndt, JW Gu, J Jaroszewski, L Schwarzenbacher, R Hanson, MA Lebeda, FJ Stevens, RC AF Arndt, JW Gu, J Jaroszewski, L Schwarzenbacher, R Hanson, MA Lebeda, FJ Stevens, RC TI The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex SO JOURNAL OF MOLECULAR BIOLOGY LA English DT Article DE neurotoxin; hemagglutinin; beta-trefoil; progenitor toxin; sugar-binding ID GANGLIOSIDE BINDING-SITE; RICIN B-CHAIN; NONTOXIC COMPONENT; CRYSTAL-STRUCTURE; MOLECULAR CHARACTERIZATION; HEMAGGLUTININ COMPONENT; SEQUENCE ALIGNMENT; EPITHELIAL-CELLS; ONE SUBCOMPONENT; IDENTIFICATION AB The hemagglutinating protein HA33 from Clostridium botulinum is associated with the large botulinum neurotoxin secreted complexes and is critical in toxin protection, internalization, and possibly activation. We report the crystal structure of serotype A HA33 (HA33/A) at 1.5 Angstrom resolution that contains a unique domain organization and a carbohydrate recognition site. In addition, sequence alignments of the other toxin complex components, including the neurotoxin BoNT/A, hemagglutinating protein HA17/A, and non-toxic non-hemagglutinating protein NTNHA/A, suggests that most of the toxin complex consists of a reoccurring beta-trefoil fold. (C) 2004 Elsevier Ltd. All rights reserved. C1 Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA. Univ Calif San Diego, Joint Ctr Struct Genomics, La Jolla, CA 92093 USA. USA, Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Toxinol Div, Frederick, MD 21702 USA. RP Stevens, RC (reprint author), Scripps Res Inst, Dept Biol Mol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA. EM stevens@scripps.edu RI Stevens, Raymond/K-7272-2015 OI Stevens, Raymond/0000-0002-4522-8725 FU NIGMS NIH HHS [GM62411] NR 51 TC 42 Z9 43 U1 0 U2 3 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-2836 J9 J MOL BIOL JI J. Mol. Biol. PD MAR 4 PY 2005 VL 346 IS 4 BP 1083 EP 1093 DI 10.1016/j.jmb.2004.12.039 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 900AM UT WOS:000227187800012 PM 15701519 ER PT J CA Minist Publ Hlth World Hlth Org Thai Minist Hlth US CDC Collaborat Armed Forces Res Inst Med Sci TI Rapid health response, assessment, and surveillance after a tsunami - Thailand, 2004-2005 (Reprinted from MMWR, vol 54, pg 61-64, 2005) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 Minist Publ Hlth, Bangkok, Thailand. Thai Minist Hlth US CDC Collaborat, Nonthaburi, Thailand. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Minist Publ Hlth, Bangkok, Thailand. NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 2 PY 2005 VL 293 IS 9 BP 1052 EP 1054 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 901LY UT WOS:000227285200005 ER PT J AU Dove, RC Matheu, EE AF Dove, RC Matheu, EE TI Ultimate deflection capacity of lightly reinforced concrete intake towers SO ACI STRUCTURAL JOURNAL LA English DT Article DE deflection; ductility; reinforced concrete ID INTAKE-OUTLET TOWERS; DYNAMICS; DESIGN AB This paper describes a series of experimental research efforts focused on characterizing the ultimate flexural behavior of lightly reinforced concrete intake towers. The main objective of this research was to provide empirical data to be used in the development of a simplified analysis procedure for seismic evaluation of this type of structures. The studies included an experimental investigation of the flexural behavior of 1/8-scale model rectangular concrete intake towers under monotonic and cyclic lateral loads. Further experimentation was conducted to quantify the influence of the parameters governing the deflection capacity of these structures. An empirical expression is presented for the ultimate deflection capacity of lightly reinforced towers with rectangular sections. C1 US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Dove, RC (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. NR 19 TC 1 Z9 1 U1 0 U2 2 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 USA SN 0889-3241 J9 ACI STRUCT J JI ACI Struct. J. PD MAR-APR PY 2005 VL 102 IS 2 BP 214 EP 223 PG 10 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 901IV UT WOS:000227277100004 ER PT J AU Cheng, S Ma, E Wang, YM Kecskes, LJ Youssef, KM Koch, CC Trociewitz, UP Han, K AF Cheng, S Ma, E Wang, YM Kecskes, LJ Youssef, KM Koch, CC Trociewitz, UP Han, K TI Tensile properties of in situ consolidated nanocrystalline Cu SO ACTA MATERIALIA LA English DT Article DE nanocrystalline; copper; mechanical property; consolidation; deformation mechanism ID SEVERE PLASTIC-DEFORMATION; ULTRAFINE-GRAINED METALS; STRAIN-RATE SENSITIVITY; MECHANICAL-BEHAVIOR; NANOSTRUCTURED METALS; SINGLE-CRYSTALS; SHEAR BANDS; THIN-FILMS; COPPER; DUCTILITY AB We have prepared Cu powders with nanocrystalline grain sizes via ball milling at liquid nitrogen temperature. An in situ consolidation technique was used to produce fully dense nanocrystalline Cu samples centimeters in lateral dimensions and about one millimeter in thickness. We report a much improved combination of tensile strength and ductility, over the tensile properties of other nanocrystalline Cu materials documented in the literature. We also demonstrate the elvated strain rate sensitivity and strong temperature dependence of the flow stress and explain the results in terms of the thermally activated deformation mechanisms operative in the nanocrystalline grains. The nearly perfectly plastic behavior and shear localization observed are discussed and compared with the strain hardening behavior and deformation modes known for other nanocrystalline metals. (C) 2004 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA. Lawrence Livermore Natl Lab, Chem & Mat Sci Directorate, Livermore, CA 94550 USA. US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. RP Ma, E (reprint author), Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA. EM ema@jhu.edu RI Ma, En/A-3232-2010; Youssef, Khaled/F-4629-2010; Koch, Carl/B-9101-2008; Cheng, Sheng/D-9153-2013; Kecskes, Laszlo/F-6880-2014; Wang, Yinmin (Morris)/F-2249-2010 OI Youssef, Khaled/0000-0001-9850-5223; Cheng, Sheng/0000-0003-1137-1926; Kecskes, Laszlo/0000-0002-1342-3729; Wang, Yinmin (Morris)/0000-0002-7161-2034 NR 67 TC 327 Z9 334 U1 16 U2 132 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD MAR PY 2005 VL 53 IS 5 BP 1521 EP 1533 DI 10.1016/j.actamat.2004.12.005 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 901EF UT WOS:000227265100026 ER PT J AU Carr, WW AF Carr, WW TI Clinical pearls and pitfalls: Peanut allergy SO ALLERGY AND ASTHMA PROCEEDINGS LA English DT Article ID FOOD ALLERGY; ANAPHYLACTIC REACTIONS; IGE CONCENTRATIONS; CHILDREN; ADOLESCENTS; POPULATION; RECURRENCE AB A case of pediatric peanut allergy is presented. Pathophysiology, clinical characteristics, diagnostic test, case management, and natural history are reviewed. Clinical Pearls and Pitfalls include: (1) About 20% of young infants will outgrow peanut allergy, especially if IgE levels measured by ImmunoCAP RAST are less than 5kU/L. (2) Cases of resensitization have been documented after negative peanut oral challenges. (3) Only a negative food challenge can provide convincing evidence that the patient has outgrown his or her peanut allergy. C1 Walter Reed Army Med Ctr, Dept Allergy & Immunol, Baltimore, MD USA. RP Carr, WW (reprint author), 14588 Mustang Path, Glenwood, MD 21738 USA. NR 17 TC 5 Z9 5 U1 0 U2 0 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1088-5412 J9 ALLERGY ASTHMA PROC JI Allergy Asthma Proc. PD MAR-APR PY 2005 VL 26 IS 2 BP 145 EP 147 PG 3 WC Allergy SC Allergy GA 923ZS UT WOS:000228948700013 PM 15971474 ER PT J AU Kalantar-Zadeh, K Abbott, KC Salahudeen, AK Kilpatrick, RD Horwich, TB AF Kalantar-Zadeh, K Abbott, KC Salahudeen, AK Kilpatrick, RD Horwich, TB TI Survival advantages of obesity in dialysis patients SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Review DE dialysis; obesity; reverse epidemiology; dialysis-risk-paradox; malnutrition-inflammation complex syndrome ID BODY-MASS INDEX; CHRONIC HEART-FAILURE; STAGE RENAL-DISEASE; MAINTENANCE HEMODIALYSIS-PATIENTS; INFLAMMATION COMPLEX SYNDROME; CARDIOVASCULAR RISK-FACTORS; TUMOR-NECROSIS-FACTOR; SHORT-TERM SURVIVAL; PERITONEAL-DIALYSIS; NUTRITIONAL-STATUS AB In the general population, a high body mass index (BMI; in kg/m(2)) is associated with increased cardiovascular disease and all-cause mortality. However, the effect of overweight (BMI: 25-30) or obesity (BMI: > 30) in patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis (MHD) is paradoxically in the opposite direction; ie, a high BMI is associated with improved survival. Although this "reverse epidemiology" of obesity or dialysis-risk-paradox is relatively consistent in MHD patients, studies in CKD patients undergoing peritonea] dialysis have yielded mixed results. Growing confusion has developed among physicians, some of whom are no longer confident about whether to treat obesity in CKD patients. A similar reverse epidemiology of obesity has been described in geriatric populations and in patients with chronic heart failure (CHF). Possible causes of the reverse epidemiology of obesity include a more stable hemodynamic status, alterations in circulating cytokines, unique neurohormonal constellations, endotoxin-lipoprotein interaction, reverse causation, survival bias, time discrepancies among competitive risk factors, and malnutrition-inflammation complex syndrome. Reverse epidemiology may have significant clinical implications in the management of dialysis, CHF, and geriatric patients, ie, populations with extraordinarily high mortality. Exploring the causes and consequences of the reverse epidemiology of obesity in dialysis patients can enhance our insights into similar paradoxes observed for other conventional risk factors, such as blood pressure and serum cholesterol and homocysteine concentrations, and in other populations Such as those with CHF, advanced age, cancer, or AIDS. Weight-gaining interventional studies in dialysis patients are urgently needed to ascertain whether they can improve survival and quality of life. C1 Harbor UCLA Med Ctr, Div Nephrol & Hypertens, Los Angeles Biomed Inst, Torrance, CA 90509 USA. Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Univ Mississippi, Dept Med, Med Ctr, Jackson, MS 39216 USA. Univ Calif Los Angeles, David Geffen Sch Med, Div Cardiol, Los Angeles, CA USA. RP Kalantar-Zadeh, K (reprint author), Harbor UCLA Med Ctr, Div Nephrol & Hypertens, Los Angeles Biomed Inst, Harbor Mailbox 406,1000 W Carson St, Torrance, CA 90509 USA. EM kamkal@ucla.edu OI Abbott, Kevin/0000-0003-2111-7112 FU NIDDK NIH HHS [DK61162] NR 119 TC 341 Z9 350 U1 1 U2 7 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAR PY 2005 VL 81 IS 3 BP 543 EP 554 PG 12 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 905KD UT WOS:000227566100003 PM 15755821 ER PT J AU Yokota, M Berglund, LG Santee, WR Buller, BJ Hoyt, RW AF Yokota, M Berglund, LG Santee, WR Buller, BJ Hoyt, RW TI Energy expenditure estimates of military field activities utilizing a pedometer. SO AMERICAN JOURNAL OF HUMAN BIOLOGY LA English DT Meeting Abstract C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1042-0533 J9 AM J HUM BIOL JI Am. J. Hum. Biol. PD MAR-APR PY 2005 VL 17 IS 2 MA 66 BP 263 EP 263 PG 1 WC Anthropology; Biology SC Anthropology; Life Sciences & Biomedicine - Other Topics GA 903BF UT WOS:000227399700074 ER PT J AU Hoge, CW Toboni, HE Messer, SC Bell, N Amoroso, P Orman, DT AF Hoge, CW Toboni, HE Messer, SC Bell, N Amoroso, P Orman, DT TI The occupational burden of mental disorders in the US Military: Psychiatric hospitalizations, involuntary separations, and disability SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article ID HEALTH-CARE; EPIDEMIOLOGY; DEPRESSION; OUTCOMES AB Objective: A recent study showed that among U. S. military personnel, mental disorders were the leading medical correlate of separation from military service. The reasons for this association have not been determined. The purpose of this study was to characterize the risk and reasons for service separation for soldiers hospitalized with mental disorders compared with those hospitalized for other illnesses. Method: Population-based electronic health care data were linked with data on separations and disability. The authors constructed a cohort of 13,971 U. S. Army soldiers first hospitalized in 1998 and followed them for up to 2 years following this first hospitalization. Results: The rate of service separation 6 months after first hospitalization was 45% among personnel whose primary hospital discharge diagnosis was a mental disorder, 27% among those with a secondary mental disorder discharge diagnosis, and 11% among those hospitalized for all other medical conditions. Separation from military service due to medical disability, misconduct and other legal problems, unauthorized work absences, behavior related to personality disorders, and alcohol rehabilitation failure was significantly more common following hospitalization for a mental disorder than for other medical conditions. Mental disorders were also significantly associated with medical separations in which there was evidence that the condition existed prior to service. Conclusions: In the military, the occupational impact of mental disorders compared with other medical conditions appears to be mediated not only by greater disease chronicity and severity but also by a variety of behavioral problems including misconduct, legal problems, unauthorized absences, and alcohol/drug-related problems. The study also points to the difficulties inherent in screening for mental disorders prior to entry into military service. C1 Walter Reed Army Inst Res, Dept Psychiat & Biobehav Sci, Div Neuropsychiat, Silver Spring, MD 20910 USA. USA, Environm Med Res Inst, Total Army Injury & Hlth Outcomes Database Projec, Natick, MA 01760 USA. Social Sectors Dev Strategies Inc, Natick, MA USA. USA, Hlth Policy & Serv Directorate Headquarters, Med Command, Ft Sam Houston, TX USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Dept Psychiat & Biobehav Sci, Div Neuropsychiat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM charles.hoge@na.amedd.army.mil NR 21 TC 90 Z9 91 U1 0 U2 3 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD MAR PY 2005 VL 162 IS 3 BP 585 EP 591 DI 10.1176/appi.ajp.162.3.585 PG 7 WC Psychiatry SC Psychiatry GA 904UP UT WOS:000227523500023 PM 15741477 ER PT J AU Pearl, JP Parris, J Hale, DA Hoffmann, SC Bernstein, WB McCoy, KL Swanson, SJ Mannon, RB Roederer, M Kirk, AD AF Pearl, JP Parris, J Hale, DA Hoffmann, SC Bernstein, WB McCoy, KL Swanson, SJ Mannon, RB Roederer, M Kirk, AD TI Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article DE depletion; immunosuppression; T cell; transplantation ID DOSE CYCLOSPORINE MONOTHERAPY; RENAL-ALLOGRAFT RECIPIENTS; TRANSPLANTATION TOLERANCE; HOMEOSTATIC PROLIFERATION; HEMATOPOIETIC CHIMERISM; HUMAN NAIVE; CAMPATH 1H; INDUCTION; IMMUNOTOXIN; REJECTION AB cell depletion facilitates reduced immunosuppression following organ transplantation and has been suggested to be pro-tolerant. However, the characteristics of post-depletional T cells have not been evaluated as they relate to tolerance induction. We therefore studied patients undergoing profound T-cell depletion with alemtuzumab or rabbit anti-thymocyte globulin following renal transplantation, evaluating the phenotype and functional characteristics of their residual cells. Naive T cells and T cells with potential regulatory function (CD4+CD25+) were not prevalent following aggressive depletion. Rather, post-depletion T cells were of a single phenotype (CD3+CD4+CD45RA-CD62L- CCR7-) consistent with depletion-resistant effector memory T cells that expanded in the first month and were uniquely prevalent at the time of rejection. These cells were resistant to steroids, deoxyspergualin or sirolimus in vitro, but were calcineurin-inhibitor sensitive. These data demonstrate that therapeutic depletion begets a limited population of functional memory-like T cells that are easily suppressed with certain immunosuppressants, but cannot be considered uniquely pro-tolerant. C1 NIDDKD, Transplant Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. Natl Naval Med Res Inst, Dept Surg, Bethesda, MD USA. Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. NIAID, Immunotechnol Sect, Vaccine Res Ctr, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. RP Kirk, AD (reprint author), NIDDKD, Transplant Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. EM AllanK@intra.niddk.nih.gov RI Kirk, Allan/B-6905-2012; Roederer, Mario/G-1887-2011 NR 47 TC 307 Z9 314 U1 0 U2 4 PU BLACKWELL MUNKSGAARD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD MAR PY 2005 VL 5 IS 3 BP 465 EP 474 DI 10.1111/j.1600-6143.2005.00759.x PG 10 WC Surgery; Transplantation SC Surgery; Transplantation GA 896UB UT WOS:000226958200009 PM 15707400 ER PT J AU Hoffmann, SC Hale, DA Kleiner, DE Mannon, RB Kampen, RL Jacobson, LM Cendales, LC Swanson, SJ Becker, BN Kirk, AD AF Hoffmann, SC Hale, DA Kleiner, DE Mannon, RB Kampen, RL Jacobson, LM Cendales, LC Swanson, SJ Becker, BN Kirk, AD TI Functionally significant renal allograft rejection is defined by transcriptional criteria SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article DE acute rejection; real-time PCR; renal allotransplantation; sub-clinical rejection ID KIDNEY-TRANSPLANT RECIPIENTS; QUANTITATIVE RT-PCR; PROTOCOL BIOPSIES; COSTIMULATORY PATHWAY; MEDICAL PROGRESS; GENE-EXPRESSION; MESSENGER-RNA; GRANZYME-B; T-BET; ACTIVATION AB Renal allograft acute cellular rejection (ACR) is a T-cell mediated disease that is diagnosed histologically. However, many normally functioning allografts have T-cell infiltrates and histological ACR, and many nonimmune processes cause allograft dysfunction. Thus, neither histological nor functional criteria are sufficient to establish a significant rejection, and the fundamental features of clinical rejection remain undefined. To differentiate allograft lymphocyte infiltration from clinically significant ACR, we compared renal biopsies from patients with ACR to patients with: sub-clinical rejection (SCR, stable function with histological rejection); no rejection; and nontransplanted kidneys. Biopsies were compared histologically and transcriptionally by RT-PCR for 72 relevant immune function genes. Neither the degree nor the composition of the infiltrate defined ACR. However, transcripts up-regulated during effector T(H)1T-cell activation, most significantly the transcription factor T-bet, the effector receptor Fas ligand and the costimulation molecule CD152 clearly (p = 0.001) distinguished the patient categories. Transcripts from other genes were equivalently elevated in SCR and ACR, indicating their association with infiltration, not dysfunction. Clinically significant ACR is not defined solely by the magnitude nor composition of the infiltrate, but rather by the transcriptional activity of the infiltrating cells. Quantitative analysis of selected gene transcripts may enhance the clinical assessment of allografts. C1 NIDDK, Transplantat Branch, DHHS, NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC USA. NCI, Pathol Lab, DHHS, NIH, Bethesda, MD 20892 USA. Univ Wisconsin, Dept Med, Madison, WI 53706 USA. RP Kirk, AD (reprint author), NIDDK, Transplantat Branch, DHHS, NIH, Bethesda, MD 20892 USA. EM Allank@intra.niddk.nih.gov RI Kirk, Allan/B-6905-2012; OI Kleiner, David/0000-0003-3442-4453 FU NIAID NIH HHS [R01 AI49285-04]; NIDDK NIH HHS [1K24 DK616962-02] NR 38 TC 88 Z9 90 U1 0 U2 0 PU BLACKWELL MUNKSGAARD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD MAR PY 2005 VL 5 IS 3 BP 573 EP 581 DI 10.1111/j.1600-6143.2005.00719.x PG 9 WC Surgery; Transplantation SC Surgery; Transplantation GA 896UB UT WOS:000226958200022 PM 15707413 ER PT J AU Jiang, SP Zeng, Q Gettayacamin, M Tungtaeng, A Wannaying, S Lim, A Hansukjariya, P Okunji, CO Zhu, SR Fang, DH AF Jiang, SP Zeng, Q Gettayacamin, M Tungtaeng, A Wannaying, S Lim, A Hansukjariya, P Okunji, CO Zhu, SR Fang, DH TI Antimalarial activities and therapeutic properties of febrifugine analogs SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM MALARIA PARASITE; I SYNTHESIS; HALOFUGINONE; DRUGS; INHIBITOR; INVITRO; VITRO; ASSAY AB Febrifugine is the active principal isolated 50 years ago from the Chinese herb chang shan (Dichroa febrifuga Lour), which has been used as an antimalarial in Chinese traditional medicine for more than 2,000 years. However, intensive study of the properties of febrifugine has been hindered for decades due to its side effects. We report new findings on the effects of febrifugine analogs compared with those of febrifugine extracted from the dry roots of D. febrifuga. The properties of the extracted febrifugine were comparable to those obtained from the standard febrifugine provided by our collaborators. A febrifugine structure-based computer search of the Walter Reed Chemical Information System identified 10 analogs that inhibited parasite growth in vitro, with 50% inhibitory concentrations ranging from 0.141 to 290 ng/ml. The host macrophages (J744 cells) were 50 to 100 times less sensitive to the febrifugine analogs than the parasites. Neuronal (NG108) cells were even more insensitive to these drugs (selectivity indices, >1,000), indicating that a feasible therapeutic index for humans could be established. The analogs, particularly halofuginone, notably reduced parasitemias to undetectable levels and displayed curative effects in Plasmodium berghei-infected mice. Recrudescence of the parasites after treatment with the febrifugine analogs was the key factor that caused the death of most of the mice in groups receiving an effective dose. Subcutaneous treatments with the analogs did not cause irritation of the gastrointestinal tract when the animals were treated with doses within the antimalarial dose range. In summary, these analogs appear to be promising lead antimalarial compounds that require intensive study for optimization for further down-selection and development. C1 Walter Reed Army Inst Res, Dept Parasitol, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Med Chem, Silver Spring, MD 20910 USA. USAMC, Dept Immunol & Med, Dept Vet Med, Armed Forces Res Inst Med Sci, Bangkok, Thailand. Washington Nat Core Inc, Annapolis, MD USA. RP Jiang, SP (reprint author), Walter Reed Army Inst Res, Dept Parasitol, Silver Spring, MD 20910 USA. EM suping.jiang@na.amedd.army.mil NR 35 TC 45 Z9 50 U1 0 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2005 VL 49 IS 3 BP 1169 EP 1176 DI 10.1128/AAC.49.3.1169-1176.2005 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 902FJ UT WOS:000227339500043 PM 15728920 ER PT J AU Roy, CJ Paragas, J Mucker, E Shamblin, J Huggins, J Nichols, D AF Roy, CJ Paragas, J Mucker, E Shamblin, J Huggins, J Nichols, D TI Development of an aerosol model of rabbitpox: Experimental infection and comparative pathogenesis SO ANTIVIRAL RESEARCH LA English DT Meeting Abstract CT 18th International Conference on Antiviral Research CY APR 11-14, 2005 CL Barcelona, SPAIN SP Int Soc Antiviral Res C1 USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD MAR PY 2005 VL 65 IS 3 BP A36 EP A36 PG 1 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 911GF UT WOS:000227989900019 ER PT J AU Gregory, K Mello, CM AF Gregory, K Mello, CM TI Immobilization of Escherichia coli cells by use of the antimicrobial peptide cecropin P1 SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID PHOSPHOLIPID-MEMBRANES; OUTER-MEMBRANE; ANTIBACTERIAL; BINDING; ANALOGS; DERMASEPTIN; DOMAIN AB An immobilization scheme for bacterial cells is described, in which the antimicrobial peptide cecropin P1 was used to trap Escherichia coli K-12 and O157:H7 cells on microtiter plate well surfaces. Cecropin P1 was covalently attached to the well surfaces, and E. coli cells were allowed to bind to the peptide-coated surface. The immobilized cells were detected colorimetrically with an anti-E. coli antibody-horseradish peroxidase conjugate. Binding curves were obtained in which the signal intensities were dependent upon the cell concentration and upon the amount of peptide attached to the well surface. After normalization for the amount of peptide coupled to the surface and the relative binding affinity of the antibody for each strain, the binding data were compared, which indicated that there was a strong preference for E. coli O157:H7 over E. coli K-12. The cells could be immobilized reproducibly at pH values ranging from 5 to 10 and at ionic strengths up to 0.50 M. C1 USA, Dev & Engn Command, Natik Soldier Ctr, Macromol Sci Team, Natick, MA 01760 USA. Univ Kentucky, Dept Chem, Lexington, KY 40506 USA. RP Mello, CM (reprint author), USA, Dev & Engn Command, Natik Soldier Ctr, Macromol Sci Team, Kansas St, Natick, MA 01760 USA. EM Charlene.mello@us.army.mil NR 29 TC 34 Z9 34 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAR PY 2005 VL 71 IS 3 BP 1130 EP 1134 DI 10.1128/AEM.71.3.1130-1134.2005 PG 5 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 907GC UT WOS:000227702900002 PM 15746309 ER PT J AU Dragon, DC Bader, DE Mitchell, J Woollen, N AF Dragon, DC Bader, DE Mitchell, J Woollen, N TI Natural dissemination of Bacillus anthracis spores in northern Canada SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article AB Soil samples were collected from around fresh and year-old bison carcasses and areas not associated with known carcasses in Wood Buffalo National Park during an active anthrax outbreak in the summer of 2001. Sample selection with a grid provided the most complete coverage of a site. Soil samples were screened for viable Bacillus anthracis spores via selective culture, phenotypic analysis, and PCR. Bacillus anthracis spores were isolated from 28.4% of the samples. The highest concentrations of B. anthracis spores were found directly adjacent to fresh carcasses and invariably corresponded to locations where the soil had been saturated with body fluids escaping the carcass through either natural body orifices or holes torn by scavengers. The majority of positive samples were found within 2 m of both year-old and fresh carcasses and probably originated from scavengers churning up and spreading the body fluid-saturated soil as they fed. Trails of lesser contamination radiating from the carcasses probably resulted from spore dissemination through adhesion to scavengers and through larger scavengers dragging away disarticulated limbs. Comparison of samples from minimally scavenged and fully necropsied carcass sites revealed no statistically significant difference in the level of B. anthracis spore contamination. Therefore, the immediate area around a suspected anthrax carcass should be considered substantially contaminated regardless of the condition of the carcass. C1 Def R&D Canada, Medicine Hat, AB T1A 8K6, Canada. Wood Buffalo Natl Pk, Ft Smith, NT, Canada. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Dragon, DC (reprint author), Def R&D Canada, POB 4000, Medicine Hat, AB T1A 8K6, Canada. EM Dan.Dragon@drdc-rddc.gc.ca NR 6 TC 32 Z9 34 U1 2 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAR PY 2005 VL 71 IS 3 BP 1610 EP 1615 DI 10.1128/AEM.71.3.1610-1615.2005 PG 6 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 907GC UT WOS:000227702900059 PM 15746366 ER PT J AU Sarasanandarajah, S Kunnil, J Bronk, BV Reinisch, L AF Sarasanandarajah, S Kunnil, J Bronk, BV Reinisch, L TI Two-dimensional multiwavelength fluorescence spectra of dipicolinic acid and calcium dipicolinate SO APPLIED OPTICS LA English DT Article ID BACTERIAL-SPORES; BACILLUS-CEREUS; RADIATION RESISTANCE; HEAT-RESISTANCE; ULTRAVIOLET; SPECTROSCOPY; ENDOSPORES AB Dipicolinic acid (DPA) and the Ca2+ complex of DPA (CaDPA) are major chemical components of bacterial spores. With fluorescence being considered for the detection and identification of spores, it is important to understand the optical properties of the major components of the spores. We report in some detail on the room-temperature fluorescence excitation and emission spectra of DPA and its calcium ion complex and provide a comparison of the excitation-emission spectrum in a dry, wet paste and aqueous form. DPA solutions have weak, if any, fluorescence, with increased fluorescence when the DPA is dry. After exposure to a broad source UV light of the DPA, wet or dry, we observe a large increase in fluorescence with a maximum intensity emission peak at around 440 run for excitation light with a wavelength of around 360 nm. There is a slight blueshift in the absorption spectra of UV-exposed DPA from the unexposed DPA solution. CaDPA in solution shows a slight fluorescence with increased fluorescence in the dry form, and a substantial increase of fluorescence was observed after UV exposure with an emission peak of around 410 run for excitation around 305 nm. The detailed excitation-emission spectra are necessary for better interpretation of the fluorescence spectra of bacterial spores where DPA is a major chemical component. (C) 2005 Optical Society of America. C1 Univ Canterbury, Dept Phys & Astron, Christchurch 1, New Zealand. USA, Res Lab, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Sarasanandarajah, S (reprint author), Univ Canterbury, Dept Phys & Astron, Christchurch 1, New Zealand. EM lou.reinisch@canterbury.ac.nz NR 26 TC 13 Z9 13 U1 1 U2 20 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAR 1 PY 2005 VL 44 IS 7 BP 1182 EP 1187 DI 10.1364/AO.44.001182 PG 6 WC Optics SC Optics GA 903XT UT WOS:000227459600009 PM 15765697 ER PT J AU O'Shea, P Akturk, S Kimmel, M Trebino, R AF O'Shea, P Akturk, S Kimmel, M Trebino, R TI Practical issues in ultra-short-pulse measurements with 'GRENOUILLE' (vol B 79, pg 683, 2004) SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Correction C1 Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA. RP O'Shea, P (reprint author), USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM poshea@nvl.army.mil RI Akturk, Selcuk/C-1291-2009 NR 1 TC 0 Z9 0 U1 2 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD MAR PY 2005 VL 80 IS 3 BP 397 EP 398 DI 10.1007/s00340-004-1724-y PG 2 WC Optics; Physics, Applied SC Optics; Physics GA 908IH UT WOS:000227780200021 ER PT J AU Massengill, PL Goco, PE Norlund, LL Muir-Padilla, J AF Massengill, PL Goco, PE Norlund, LL Muir-Padilla, J TI Enzymatic recontouring of auricular cartilage in a rabbit model SO ARCHIVES OF FACIAL PLASTIC SURGERY LA English DT Article ID NONSURGICAL CORRECTION; DEFORMITIES AB Objective: To evaluate the effectiveness of contouring auricular cartilage in a rabbit model using biologically, active enzymes injected subcutaneously. Methods: The first phase determined the most effective volume and concentration required to affect the cartilage. To accomplish this task, we used ex vivo rabbit ears from a slaughterhouse. In the second phase, we injected 1 mL of hyaluronidase (150 U per milliliter of isotonic sodium chloride solution [saline]), elastase (1 mg per milliliter of saline), or saline into the ears of live rabbits. The study took place at the Madigan Army Medical Center (Tacoma, Wash), and included 10 animals. In each rabbit, we injected the test compound in one ear and saline in the other ear (control). We injected hyaluronidase in 5 ears and elastase in 5 ears. After injection, the ears were contoured and splinted for 4 weeks. In the third phase, we changed the injection pathway in 5 animals. Results: At 4 weeks, 4 (80%) of the 5 ears injected with hyaluronidase showed full response and 1 (20%) had a partial response. Of the 5 ears injected with elastase, 4 (80%) showed a full response while 1 (20%) demonstrated a partial response. There was a response in all 10 of the ears injected with a test compound. Of the 10 control ears, 3 (30%) showed a partial response. At 6 weeks, approximately 6 (30%) of the ears had maintained contour demonstrating a full response. The difference between the test ears and the control ears was statistically significant (P = .006). Compared with the control ears, the results were statistically significant for elastase (P = .004) and hyaluronidase (P = .02). Overall, both agents demonstrated a subjective and objective response compared with control ears. Conclusion: This study demonstrates-that bioactive enzymes and splinting can be effective in correcting ear deformities in a rabbit model. C1 Womack Army Med Serv, Otolaryngol Serv, Ft Bragg, NC 28310 USA. Madigan Army Med Ctr, Otolaryngol Serv, Dept Surg, Tacoma, WA 98431 USA. Madigan Army Med Ctr, Dept Clin Invest, Tacoma, WA 98431 USA. Madigan Army Med Ctr, Dept Pathol, Tacoma, WA 98431 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. RP Massengill, PL (reprint author), Womack Army Med Serv, Otolaryngol Serv, Ft Bragg, NC 28310 USA. EM phillip.massengill@na.amedd.army.mil NR 7 TC 1 Z9 1 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 1521-2491 J9 ARCH FACIAL PLAST S JI Arch. Facial Plast. Surg. PD MAR-APR PY 2005 VL 7 IS 2 BP 104 EP 110 DI 10.1001/archfaci.7.2.104 PG 7 WC Surgery SC Surgery GA 983HE UT WOS:000233221300006 PM 15781721 ER PT J AU Sowers, TS AF Sowers, TS TI Beyond the soldier and the state: Contemporary operations and variance in principal-agent relationships SO ARMED FORCES & SOCIETY LA English DT Article ID CIVIL-MILITARY RELATIONS; CENTRAL BANK INDEPENDENCE; FEAVER; CRISIS; DAUBER; DESCH AB Starting from Clausewitz and continuing through Samuel Huntington's landmark study The Soldier and the State, civil-military studies have largely focused on the interplay between two actors: a nation's political masters and its military.(1) While much of civil-military theory still rests on Huntington's seminal work, numerous criticisms of his theory have emerged. By stating that Huntington's approach largely ignores the day-to-day, strategic interactions between soldiers and civilians, Peter Feaver first proposed in this journal that these interactions are best understood through an institutional lens: the application of principal-agent theory.(2) This journal has also seen criticism of Feaver&PRIME; s institutional approach. James Burk and Andrew Bacevich claim that Feaver&PRIME; s focus on the strategic interactions of only two actors-the soldier and the civilian leaders of the state-limits his theory&PRIME; s ability to explain contemporary civil-military relations. Modern military operations include more actors than just soldiers and states. Relationships between soldiers and authorities beyond the state, what Burk defines as "transnational actors" such as coalitions or the United Nations (UN), increasingly determine the actions of the soldier.(4) Feaver recognizes these limits, that focusing on a monolithic soldier and state "abstracts from the reality that... civilian principals and military agents are in fact numerous and diverse."(5) The shackles of a two-actor model need to be broken. As a contribution to theory, this article applies Feaver&PRIME; s theoretical framework to look beyond the soldier and the state. Can Feaver's approach be applied to situations when actors outside of the civilians commonly referred to as "the state" attempt to influence the military ?(6) Is the soldier's relationship with the state primary, or might other relationships with transnational actors (e.g., UN, North Atlantic Treaty Organisation (NATO), coalitions) take precedence? In an environment of multiple relationships, how might relationships beyond the soldier and the state vary? In expanding Feaver&PRIME; s framework, this article explores this variation and identifies a need for a more nuanced terminology to describe these relationships. While introducing terminology that more accurately describes the relationships found in contemporary military operations is important, this article also begins to explore why. Why might this variance be observed? Might factors outside of Feaver&PRIME; s institutional model explain this variance? In her earlier application of institutional theory to civil-military relations, Deborah Avant makes a powerful argument that nationality, a factor exogenous to Feaver&PRIME; s framework, explains why soldiers from different nations may perceive their relationship with the state differently.(7) We accept this contention, that the domestic civilmilitary environment conditions how soldiers consider their relationship to the state. It follows that nationality may also condition a soldier&PRIME; s perception of relationships with higher authorities beyond the state. The idea that different nationalities may condition the various relationships found in contemporary military operations raises a number of questions pertinent to both civil-military relations and institutional theory. Are soldiers from certain nations more responsive to coalition goals and objectives as opposed to national objectives? Can soldiers conditioned to follow instructions only from a state be responsive to demands from beyond the state? In short, are all militaries created equal to deal with the multiple actors found in contemporary military operations? As a contribution to practice, this article seeks to clarify the plethora of relationships found in contemporary operational environments. If it can be determined that the soldier considers relationships with higher authorities quite differently, this holds broad implications as to just who controls soldiers in contemporary military operations. This article employs a case study approach, examining the multiple command relationships found in Kosovo, to expand Feaver&PRIME; s theoretical framework beyond the state. C1 USA, Special Forces, Washington, DC USA. RP Sowers, TS (reprint author), USA, Special Forces, Washington, DC USA. EM thomas.sowers@us.army.mil NR 28 TC 5 Z9 5 U1 1 U2 5 PU TRANSACTION PUBLISHERS PI PISCATAWAY PA RUTGERS UNIV, DEPT 8010, 35 BERRUE CIRCLE, PISCATAWAY, NJ 08854-8042 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 2005 VL 31 IS 3 BP 385 EP + DI 10.1177/0095327X0503100304 PG 26 WC Political Science; Sociology SC Government & Law; Sociology GA 925AU UT WOS:000229024700003 ER PT J AU Abbruzzese, PM AF Abbruzzese, PM TI Grave new world: Security challenges in the twenty-first century. SO ARMED FORCES & SOCIETY LA English DT Book Review C1 US Mil Acad, W Point, NY USA. RP Abbruzzese, PM (reprint author), US Mil Acad, W Point, NY USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PUBLISHERS PI PISCATAWAY PA RUTGERS UNIV, DEPT 8010, 35 BERRUE CIRCLE, PISCATAWAY, NJ 08854-8042 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 2005 VL 31 IS 3 BP 468 EP 470 DI 10.1177/0095327X0503100309 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA 925AU UT WOS:000229024700008 ER PT J AU Zhang, W Sinha, J Smith, LA Inan, M Meagher, MM AF Zhang, W Sinha, J Smith, LA Inan, M Meagher, MM TI Maximization of production of secreted recombinant proteins in Pichia pastoris fed-batch fermentation SO BIOTECHNOLOGY PROGRESS LA English DT Article ID GROWTH-RATE; METHANOL; CULTURE; YEAST; OPTIMIZATION; STRATEGY; SYSTEM AB Pontryagin's Maximum Principle has been applied for optimization of secreted proteins from Pichia pastoris fed-batch fermentation. The objective of this work is to maximize the total accumulated product per unit operation time under different given conditions and system constraints. To obtain optimal solutions, an automated curve-fitting software, Table Curve 2D, was employed to construct the necessary mathematical models and solve the complicated functions. In the solution processes, the end of the glycerol batch phase was defined as the initial state of the system, the end of the methanol fed-batch phase as the final state, the cell mass produced along with product accumulated as state variables, and the specific growth rate (U) as the control variable. Initially, a relationship between the specific production rate (p) and mu was established. Then, according to Pontryagin's Maximum Principle, the admissible range of mu and its trajectories for the optimal operations were determined. Four representative cases with different combinations of the operation time along with the initial and final states were evaluated. A close correlation was obtained between the predicted values of the model equation with the experimental results from the Pichia pastoris fed-batch fermentations producing secreted a-galactosidase. The approaches proposed here greatly simplify the computational processes and validate the optimization strategy as a generalized approach to maximize the yield from fed-batch fermentations. C1 Univ Nebraska, Dept Chem Engn, Lincoln, NE 68588 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Meagher, MM (reprint author), Univ Nebraska, Dept Chem Engn, Lincoln, NE 68588 USA. EM mmeagher1@unl.edu RI Inan, Mehmet/D-9890-2012; OI Inan, Mehmet/0000-0003-1806-7927 NR 22 TC 38 Z9 42 U1 4 U2 18 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 8756-7938 J9 BIOTECHNOL PROGR JI Biotechnol. Prog. PD MAR-APR PY 2005 VL 21 IS 2 BP 386 EP 393 DI 10.1021/bp049811n PG 8 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA 913CF UT WOS:000228127200010 PM 15801775 ER PT J AU Cassidy, RA Natarajan, S Vaughan, GM AF Cassidy, RA Natarajan, S Vaughan, GM TI The link between the insecticide heptachlor epoxide, estradiol, and breast cancer SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Article; Proceedings Paper CT Expedition Inspiration Symposium on Breast Cancer - The Development and Validation of New Therapeutics CY 2004 CL Sun Valley, ID DE breast cancer; DDE; DNA damage; estradiol; heptachlor epoxide; nitric oxide; oxidant; oxychlordane; tamoxifen ID NITRIC-OXIDE SYNTHASE; INTRACELLULAR CALCIUM TRANSIENTS; ESTROGEN-RECEPTOR-ALPHA; HUMAN-MILK; ORGANOCHLORINE COMPOUNDS; ENDOTHELIAL-CELLS; SERUM ESTRADIOL; IN-VITRO; RISK; RESIDUES AB Given the suspected effects of estrogens on breast cancer, xenoestrogenic insecticides may be a risk factor. Studies of the weak xenoestrogen, 1,1-dichloro-2,2- bis( p-chlorophenyl) ethylene (DDE), have failed to demonstrate a causal relationship, though another estrogenic organochlorine insecticide, dieldrin, belonging to the cyclodiene family, has recently been linked to breast cancer. Other cyclodienes such as heptachlor epoxide ( HE) and oxychlordane (OC) present in breast tissue have not been evaluated as rigorously, presumably due to their lower concentration and lower recovery using solvent extraction procedures. We used sparging extraction coupled with gas chromatography to determine the levels of HE, OC, and DDE in adipose tissue within breast biopsies in a series of 34 women evaluated for breast abnormality. Of the three insecticides tested, only HE ( p = 0.007) was positively associated with prevalence of breast cancer in the biopsies. In rapid, non-genomic studies using isolated human leukocytes, flow cytometric methods were used to measure HE-induced oxidants and DNA damage. These studies indicated that HE, at concentrations similar to those in breast biopsies, induced an inverted-U increase in intracellular oxidants and DNA strand breaks [ both blocked by specific nitric oxide-(NO-) synthesis blockade with L-NMMA] in human polymorphonuclear leukocytes (PMNs). HE-treated PMNs also induced damage to surrounding lymphocytes in mixed-leukocyte incubations ( also inhibited by NO blockade). The HE-induced changes in NO were inhibited by 17 beta-estradiol-(17 beta-E-2) receptor antagonists and were mimicked by similar concentrations of 17 beta-E-2. The addition of tumor necrosis factor-alpha (TNF-alpha) increased intracellular oxidants and DNA damage and shifted the responses to lower HE concentrations. This study, along with others, suggests that HE-induced NO production may contribute to initiation, promotion, and progression of cancer. C1 ToxFree Inc, Tell City, IN USA. Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79430 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cassidy, RA (reprint author), 6160 St Joe Cemetery Rd, Tell City, IN 47586 USA. EM rcassidy@dcci.com NR 62 TC 25 Z9 27 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD MAR PY 2005 VL 90 IS 1 BP 55 EP 64 DI 10.1007/s10549-004-2755-0 PG 10 WC Oncology SC Oncology GA 907FU UT WOS:000227702000008 PM 15770527 ER PT J AU Baillargeon, J Pollock, BH Kristal, AR Bradshaw, P Hernandez, J Basler, J Higgins, B Lynch, S Rozanski, T Troyer, D Thompson, I AF Baillargeon, J Pollock, BH Kristal, AR Bradshaw, P Hernandez, J Basler, J Higgins, B Lynch, S Rozanski, T Troyer, D Thompson, I TI The association of body mass index and prostate-specific antigen in a population-based study SO CANCER LA English DT Article DE prostate carcinoma; body mass index; cancer risk; prostate-specific antigen ID RADICAL PROSTATECTOMY; PATHOLOGICAL VARIABLES; UNITED-STATES; CANCER RISK; MEN; OBESITY; ANTHROPOMETRY; BLACKS; WHITES; COHORT AB BACKGROUND. Recent studies of men with prostate carcinoma suggest that obesity may be associated with more advanced-stage disease and lower overall Survival rates. One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate-specific antigen (PSA) is widely used to screen for prostate carcinoma. METHODS. The authors examined the association between BMI and PSA in a population-based study of 2779 men without prostate carcinoma. Between 2001 and 2004, these men were enrolled in a study sponsored by the San Antonio Center of Biomarkers of Risk, a clinical and epidemiologic center of the Early Detection Research Network of the National Cancer Institute. RESULTS. The mean PSA value decreased in a linear fashion with all increase in BMI category, from 1.01 ng/mL in normal weight men to 0.69 ng/mL in obese (Class III) men, after adjusting for race/ethnicity and age. CONCLUSIONS. Lower levels of PSA in obese and overweight men Could mask biologically consequential prostate carcinoma. (C) 2005 American Cancer Society. C1 Univ Texas, Hlth Sci Ctr, Ctr Biostat & Epidemiol, San Antonio, TX 78284 USA. Univ Texas, Hlth Sci Ctr, Dept Pediat, San Antonio, TX 78285 USA. Fred Hutchinson Canc Res Ctr, Canc Prevent Res Program, Seattle, WA 98104 USA. Univ Texas, Hlth Sci Ctr, Dept Surg, San Antonio, TX 78285 USA. Wilford Hall USAF Med Ctr, Dept Surg, San Antonio, TX 78236 USA. Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA. Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78285 USA. RP Baillargeon, J (reprint author), Univ Texas, Hlth Sci Ctr, Ctr Biostat & Epidemiol, 7703 Floyd Curl Dr, San Antonio, TX 78284 USA. EM baillargeon@uthscsa.edu OI Kristal, Alan/0000-0002-7329-1617 FU NCI NIH HHS [U01 CA86402] NR 18 TC 142 Z9 150 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD MAR 1 PY 2005 VL 103 IS 5 BP 1092 EP 1095 DI 10.1002/cncr.20856 PG 4 WC Oncology SC Oncology GA 898ZH UT WOS:000227114200027 PM 15668913 ER PT J AU Barrett, AH Marando, G Leung, H Kaletunc, G AF Barrett, AH Marando, G Leung, H Kaletunc, G TI Effect of different enzymes on the textural stability of shelf-stable bread SO CEREAL CHEMISTRY LA English DT Article ID ALPHA-AMYLASE; WHITE BREAD; STARCH; GLYCEROL; STORAGE; DOUGH; TEMPERATURE; BREADMAKING; SYSTEMS AB Three enzyme systems (2 amylase-based and 1 protease-based) were tested in shelf-stable bread to determine effectiveness in preserving texture during storage for eight weeks. Each enzyme was tested in formulations without glycerol or with 6% glycerol. Bread samples were analyzed to determine physical properties (crumb density, crust-to-crumb ratio, rate of moisture distribution from crumb to crust), mechanical properties (modulus, and a parameter [Cl] describing resistance to high levels of deformation obtained by fitting stress-strain data to a three-parameter function), and thermal properties (thermal stability and enthalpy of transitions) as a function of storage time. Mechanical properties were further analyzed to predict asymptotic firmness. Bread firmness after storage as evaluated in terms of modulus and Cl were lower in all enzyme-added systems, the effect of protease being the most significant. Enzymes had less effect on glycerol-containing systems with no apparent trend. The breads had complex thermal behavior and exhibited multiple transitions. Both amylase preparations in the presence of glycerol reduced the amount of starch recrystallization. C1 Ohio State Univ, Dept Food Agr & Biol Engn, Columbus, OH 43210 USA. USA, Natick Soldier Ctr, Combat Feeding Directorate, Performance Enhancement & Food Safety Team, Natick, MA 01760 USA. Frito Lay Inc, Plano, TX USA. RP Kaletunc, G (reprint author), Ohio State Univ, Dept Food Agr & Biol Engn, Columbus, OH 43210 USA. EM kaletunc.1@osu.edu RI Kaletunc, Gonul/B-8806-2012 NR 26 TC 13 Z9 13 U1 2 U2 15 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 USA SN 0009-0352 J9 CEREAL CHEM JI Cereal Chem. PD MAR-APR PY 2005 VL 82 IS 2 BP 152 EP 157 DI 10.1094/CC-82-0152 PG 6 WC Chemistry, Applied; Food Science & Technology SC Chemistry; Food Science & Technology GA 910NF UT WOS:000227937500007 ER PT J AU Ownby, DR Belden, JB Lotufo, GR Lydy, MJ AF Ownby, DR Belden, JB Lotufo, GR Lydy, MJ TI Accumulation of trinitrotoluene (TNT) in aquatic organisms: Part 1 - Bioconcentration and distribution in channel catfish (Ictalurus punctatus) SO CHEMOSPHERE LA English DT Article DE Ictalurus punctatus; trinitrotoluene; biotransformation; organ distribution; toxicokinetics ID 2,4,6-TRINITROTOLUENE; TOXICITY; TRANSFORMATION; CYTOTOXICITY; SEDIMENT AB Little is currently known regarding the toxicokinetics of TNT in fish. In the present study, the bioconcentration and distribution of trinitrotoluene (TNT) and TNT biotransformation products was investigated in juvenile channel catfish by exposing catfish to 14 C-labeled TNT in water. Uptake experiments showed relatively fast rates (k(u) = 10.1 mlg(-1) h(-1)) for TNT from the water; however, bioconcentration factors for TNT were low (0.79mlg(-1)) due to rapid biotransformation and potential elimination of TNT. Accumulation of extractable radioactivity (TNT and all extractable biotransformation products) was much greater (BCF = 10. 5 mlg(-1)) than that for parent compound. TNT (parent compound) bioconcentrated to the greatest extent in the gills of the fish, while total radioactivity bioconcentrated to the greatest extent in the viscera. Residual portions of the fish that contained muscle and skin had lower concentrations of TNT than the whole fish, indicating that ingestion of fish filets would result in decreased exposure to human consumers. Although the bioconcentration potential of TNT is very low, future research needs to be conducted to identify the biotransformation products that make up most of the radioactivity in exposed fish and evaluate their potential to promote toxicity. (C) 2004 Elsevier Ltd. All rights reserved. C1 So Illinois Univ, Fisheries & Illinois Aquaculture Ctr, Carbondale, IL 62901 USA. So Illinois Univ, Dept Zool, Carbondale, IL 62901 USA. US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Lydy, MJ (reprint author), So Illinois Univ, Fisheries & Illinois Aquaculture Ctr, Carbondale, IL 62901 USA. EM mlydy@siu.edu RI Ownby, David/B-7688-2008; Belden, Jason/H-1764-2014 OI Ownby, David/0000-0001-8517-2044; Belden, Jason/0000-0002-0432-7700 NR 23 TC 51 Z9 52 U1 3 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2005 VL 58 IS 9 BP 1153 EP 1159 DI 10.1016/j.chemosphere.2004.09.059 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 902RZ UT WOS:000227375500001 PM 15667836 ER PT J AU Belden, JB Ownby, DR Lotufo, GR Lydy, MJ AF Belden, JB Ownby, DR Lotufo, GR Lydy, MJ TI Accumulation of trinitrotoluene (TNT) in aquatic organisms: Part 2 - Bioconcentration in aquatic invertebrates and potential for trophic transfer to channel catfish (Ictalurus punctatus) SO CHEMOSPHERE LA English DT Article DE Ictalurus punctatus; trinitrotoluene; benthic invertebrates; bioaccumulation; bioconcentration ID CHIRONOMUS-TENTANS; HYALELLA-AZTECA; 2,4,6-TRINITROTOLUENE; TOXICITY; TRANSFORMATION; SEDIMENT AB The potential of TNT to accumulate in aquatic organisms was assessed by determining bioconcentration factors for TNT and TNT biotransformation products using two benthic invertebrates (Chironomus tentans and Lumbriculus variegatus), and by determining the bioaccumulation factor of TNT and TNT biotransformation products due to TNT exposure via feeding for channel catfish (Ictalurus punctatus). In all three species, TNT was rapidly biotransformed resulting in minimal accumulation. The bioconcentration factors for parent TNT ranged from 3 to 4mlg(-1) for the invertebrates studied, while the TNT bioaccumulation factor for catfish via oral exposure of food pellets was 2.4 x 10(-5)gg(-1) based on the concentration of TNT in the food pellet. As indicated by this small bioaccumulation factor, TNT accumulation in channel catfish through trophic transfer would be negligible compared to aqueous exposure (previously reported BCF of 0.79 ml g(-1)). TNT extractable biotransformation products accumulated to a greater degree than parent TNT for all three species. In addition, a large fraction of the radioactivity within all three species resisted solvent extraction. The highest bioconcentration factors occurred in L. variegatus with extractable radioactivity measuring 76mlg(-1) and total radioactivity measuring 216mlg(-1). Because the bioaccumulation of TNT is very low compared to the bioaccumulation of its biotransformation products, further research including identifying and determining the relative toxicities of these biotransformation products is necessary to fully evaluate the environmental risk posed by exposure to TNT. (C) 2004 Elsevier Ltd. All rights reserved. C1 So Illinois Univ, Fisheries & Illinois Aquaculture Ctr, Carbondale, IL 62901 USA. So Illinois Univ, Dept Zool, Carbondale, IL 62901 USA. US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Lydy, MJ (reprint author), So Illinois Univ, Fisheries & Illinois Aquaculture Ctr, Carbondale, IL 62901 USA. EM mlydy@siu.cdu RI Ownby, David/B-7688-2008; Belden, Jason/H-1764-2014 OI Ownby, David/0000-0001-8517-2044; Belden, Jason/0000-0002-0432-7700 NR 17 TC 48 Z9 48 U1 2 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2005 VL 58 IS 9 BP 1161 EP 1168 DI 10.1016/j.chemosphere.2004.09.058 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 902RZ UT WOS:000227375500002 PM 15667837 ER PT J AU Shorr, AF Jackson, WL AF Shorr, AF Jackson, WL TI Transfusion practice in the ICU - When will we apply the evidence? SO CHEST LA English DT Editorial Material ID CRITICALLY-ILL PATIENTS; BLOOD-CELL TRANSFUSION; ANEMIA; ERYTHROPOIETIN; PATIENT; TRIAL; CARE C1 Walter Reed Army Med Ctr, Pulmonary Crit Care & Sleep Med Serv, Dept Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Crit Care Med Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Shorr, AF (reprint author), Walter Reed Army Med Ctr, Pulmonary Crit Care & Sleep Med Serv, Dept Med, Washington, DC 20307 USA. EM afshorr@dnamail.com NR 22 TC 5 Z9 9 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD MAR PY 2005 VL 127 IS 3 BP 702 EP 705 DI 10.1378/chest.127.3.702 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 908HG UT WOS:000227777500007 PM 15764745 ER PT J AU Jackson, WL AF Jackson, WL TI Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock? SO CHEST LA English DT Review DE adrenal insufficiency; endotracheal intubation; etomidate; sepsis; septic shock ID CRITICALLY-ILL PATIENTS; SEVERELY STRESSED PATIENTS; RAPID-SEQUENCE INTUBATION; MULTIPLE TRAUMA PATIENTS; LOW-DOSE HYDROCORTISONE; ADRENOCORTICAL FUNCTION; ADRENAL INSUFFICIENCY; CORTISOL RESPONSE; SURGICAL PATIENTS; CRITICAL ILLNESS AB Etomidate is commonly used for the facilitation of endotracheal intubation. While etomidate possesses multiple qualities that are beneficial in hemodynamically unstable patients who require a sedative or amnestic, its potential to negatively impact corticosteroid production is well-documented. Given the frequency of relative adrenal insufficiency observed in the critically ill and the increasing use of corticosteroids in patients with septic shock, an appraisal of the status of etomidate as an induction agent in patients with evolving or established septic shock is indicated. A review of the relevant literature suggests that its use in this setting may be harmful. It is proposed that, pending the performance of a randomized, controlled clinical trial, considerable caution should accompany its administration in patients with evolving or established septic shock. The potential role for concomitant empiric steroid replacement and the comparability of alternative induction regimens are also discussed. C1 Walter Reed Army Med Ctr, Dept Surg, Crit Care Med Serv, Washington, DC 20307 USA. RP Jackson, WL (reprint author), Walter Reed Army Med Ctr, Dept Surg, Crit Care Med Serv, Bldg 2,Room 3M12,6900 Georgia Ave NW, Washington, DC 20307 USA. EM William.jackson1@NA.AMEDD.ARMY.MIL NR 108 TC 104 Z9 105 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD MAR PY 2005 VL 127 IS 3 BP 1031 EP 1038 DI 10.1378/chest.127.3.1031 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 908HG UT WOS:000227777500052 PM 15764790 ER PT J AU Davis, KA Hospenthal, DR AF Davis, KA Hospenthal, DR TI Effect of colonization with methicillin-resistant Staphylococcus aureus on subsequent infection - Reply SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID NOSOCOMIAL TRANSMISSION; CARRIAGE; RATES C1 Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Dept Med, Ft Sam Houston, TX 78234 USA. RP Davis, KA (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Dept Med, Ft Sam Houston, TX 78234 USA. EM kepler.davis@amedd.army.mil NR 9 TC 1 Z9 1 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR 1 PY 2005 VL 40 IS 5 BP 768 EP 769 DI 10.1086/427761 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 904JO UT WOS:000227492700023 ER PT J AU Crothers, BA AF Crothers, BA TI The Bethesda System 2001: Update on terminology and application SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID ATYPICAL SQUAMOUS-CELLS; NORMAL ENDOMETRIAL CELLS; UNDETERMINED SIGNIFICANCE; INTRAEPITHELIAL LESION; PAPANICOLAOU SMEARS; CERVICAL CYTOLOGY; FOLLOW-UP; ENDOCERVICAL STATUS; SIGNIFICANCE ASCUS; CANNOT EXCLUDE C1 Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. RP Crothers, BA (reprint author), Walter Reed Army Med Ctr, Dept Pathol, Ward 47,Bldg 2,6900 Georgia Ave NW, Washington, DC 20307 USA. EM barbara.crothers@na.amedd.army.mil NR 34 TC 12 Z9 14 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 98 EP 107 DI 10.1097/01.grf.0000151572.99437.a5 PG 10 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200011 PM 15725862 ER PT J AU Russell, J Crothers, BA Kaplan, KJ Zahn, CM AF Russell, J Crothers, BA Kaplan, KJ Zahn, CM TI Current cervical screening technology considerations: Liquid-based cytology and automated screening SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID CONVENTIONAL PAPANICOLAOU SMEARS; MULTICENTER CLINICAL-TRIALS; THIN-LAYER PREPARATIONS; QUALITY-CONTROL; QC SYSTEM; THINPREP(TM) PROCESSOR; COST-EFFECTIVENESS; AUTOPAP SYSTEM; PAPNET-SYSTEM; INTENDED-USE C1 Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Univ Hlth Sci, Uniformed Serv, Dept Obstet & Gynecol, Bethesda, MD USA. RP Kaplan, KJ (reprint author), Walter Reed Army Med Ctr, Dept Pathol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM keith.kaplan@na.amedd.army.mil NR 57 TC 0 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 108 EP 119 DI 10.1097/01.grf.0000151587.62709.f3 PG 12 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200012 PM 15725863 ER PT J AU Uribe, PS Kaplan, KJ Zahn, CM AF Uribe, PS Kaplan, KJ Zahn, CM TI Evidence for the role of human papillomavirus DNA testing in primary screening fog cervical dysplasia SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID LOW-RESOURCE SETTINGS; HYBRID CAPTURE-II; HIGH-RISK; CANCER; HPV; WOMEN; DETECT; SENSITIVITY; PROVINCE C1 Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Univ Hlth Sci, Uniformed Serv, Dept Obstet & Gynecol, Bethesda, MD USA. RP Kaplan, KJ (reprint author), Walter Reed Army Med Ctr, Dept Pathol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM keith.kaplan@na.amedd.army.mil NR 21 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 120 EP 126 DI 10.1097/01.grf.0000151589.00827.65 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200013 PM 15725864 ER PT J AU Bidus, MA Zahn, CM Maxwell, GL Rodriguez, M Elkas, JC Rose, GS AF Bidus, MA Zahn, CM Maxwell, GL Rodriguez, M Elkas, JC Rose, GS TI The role of self-collection devices fog cytology and human papillomavirus DNA testing in cervical cancer screening SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID POLYMERASE-CHAIN-REACTION; CERVICOVAGINAL LAVAGE; SAMPLES; HPV; TAMPON C1 Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Washington, DC 20307 USA. Univ Hlth Sci, Uniformed Serv, Dept Obstet & Gynecol, Bethesda, MD USA. RP Bidus, MA (reprint author), Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Bldg 2,2nd Floor,Room 2J06,6900 Georgia Ave NW, Washington, DC 20307 USA. EM michael.bidus@na.amedd.army.mil NR 21 TC 7 Z9 7 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 127 EP 132 DI 10.1097/01.grf.0000151569.46072.34 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200014 PM 15725865 ER PT J AU Farley, J McBroom, JW Zahn, CM AF Farley, J McBroom, JW Zahn, CM TI Current techniques for the evaluation of abnormal cervical cytology SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID SQUAMOUS INTRAEPITHELIAL LESIONS; ELECTROSURGICAL EXCISION PROCEDURE; DIGITAL IMAGING COLPOSCOPY; COLD-KNIFE CONIZATION; LARGE LOOP EXCISION; VISUAL INSPECTION; ACETIC-ACID; PAPILLOMAVIRAL INFECTION; SCREENING TECHNIQUES; TRANSFORMATION ZONE C1 Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Honolulu, HI 96859 USA. Univ Hlth Sci, Uniformed Serv, Dept Obstet & Gynecol, Bethesda, MD USA. RP Farley, J (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM john.farley@us.army.mil NR 59 TC 1 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 133 EP 146 DI 10.1097/01.grf.0000151583.78239.47 PG 14 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200015 PM 15725866 ER PT J AU Brown, D Berran, P Kaplan, KJ Winter, WE Zahn, CM AF Brown, D Berran, P Kaplan, KJ Winter, WE Zahn, CM TI Special situations: Abnormal cervical cytology during pregnancy SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID 2001 CONSENSUS GUIDELINES; INTRAEPITHELIAL NEOPLASIA; CONE CERCLAGE; MANAGEMENT; POSTPARTUM; CANCER; WOMEN; REGRESSION; DYSPLASIA; EXPERIENCE C1 Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC USA. Univ Hlth Sci, Uniformed Serv, Dept Obstet & Gynecol, Bethesda, MD USA. RP Winter, WE (reprint author), Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM william.winter@amedd.army.mil NR 37 TC 5 Z9 8 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 178 EP 185 DI 10.1097/01.grf.0000151570.53696.04 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200018 PM 15725869 ER PT J AU Stany, M Rose, GS Zahn, CM AF Stany, M Rose, GS Zahn, CM TI Special situations: Abnormal cervical cytology in Immunocompromised patients SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; SQUAMOUS INTRAEPITHELIAL LESIONS; HUMAN-PAPILLOMAVIRUS INFECTION; ACTIVE ANTIRETROVIRAL THERAPY; RENAL-TRANSPLANT PATIENTS; SEROPOSITIVE WOMEN; RISK-FACTORS; NEOPLASIA; HIV; PREVALENCE C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. Univ Hlth Sci, Uniformed Serv, Dept Obstet & Gynecol, Bethesda, MD USA. RP Stany, M (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM michael.stany@na.amedd.army.mil NR 29 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 186 EP 192 DI 10.1097/01.grf.0000151588.62709.17 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200019 PM 15725870 ER PT J AU Dainty, LA Elkas, JC Rose, GS Zahn, CM AF Dainty, LA Elkas, JC Rose, GS Zahn, CM TI Controversial topics in abnormal cervical cytology: "See and treat" SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID SQUAMOUS INTRAEPITHELIAL LESIONS; LOOP ELECTROSURGICAL EXCISION; TRANSFORMATION ZONE LLETZ; RANDOMIZED TRIAL; PAPANICOLAOU SMEAR; DIATHERMY LOOP; NEOPLASIA; MANAGEMENT; DIAGNOSIS; WOMEN C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. Univ Hlth Sci, Uniformed Serv, Dept Obstet & Gynecol, Bethesda, MD USA. RP Dainty, LA (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Bldg 2,2nd Floor,6900 Georgia Ave NW, Washington, DC 20307 USA. EM louis.dainty@na.amedd.army.mil NR 33 TC 5 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 193 EP 201 DI 10.1097/01.grf.0000151582.70615.06 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200020 PM 15725871 ER PT J AU Bidus, MA Elkas, JC Rodriguez, M Maxwell, GL Rose, GS AF Bidus, MA Elkas, JC Rodriguez, M Maxwell, GL Rose, GS TI The clinical utility of the diagnostic endocervical curettage SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID ABNORMAL CERVICAL CYTOLOGY; 2001 CONSENSUS GUIDELINES; ATYPICAL GLANDULAR CELLS; ADENOCARCINOMA IN-SITU; MANAGEMENT; BRUSH; CYTOBRUSH; COLPOSCOPY; CONTRIBUTE; SAFETY C1 Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. RP Bidus, MA (reprint author), Walter Reed Army Med Ctr, Div Gynecol Oncol, Bldg 2,2nd Floor,Room 2J06,6900 Georgia Ave NW, Washington, DC 20307 USA. EM michael.bidus@na.amedd.army.mil NR 30 TC 1 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 202 EP 208 DI 10.1097/01.grf.0000151568.68943.dc PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200021 PM 15725872 ER PT J AU Parker, MF AF Parker, MF TI Emerging technology in cervical cancer screening: Spectroscopy SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID IN-VIVO DETECTION; SQUAMOUS INTRAEPITHELIAL LESIONS; INFRARED RAMAN-SPECTROSCOPY; FLUORESCENCE; NEOPLASIA; DIAGNOSIS; DYSPLASIA; PRECANCER C1 USA, Med Res & Mat Command Telemed & Adv Technol Res C, Ft Detrick, MD 21702 USA. RP Parker, MF (reprint author), USA, Med Res & Mat Command Telemed & Adv Technol Res C, Ft Detrick, MD 21702 USA. EM parker@tatrc.org NR 25 TC 11 Z9 11 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD MAR PY 2005 VL 48 IS 1 BP 209 EP 217 DI 10.1097/01.grf.0000151586.23981.74 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 959PW UT WOS:000231531200022 PM 15725873 ER PT J AU Shorr, AF AF Shorr, AF TI Preventing pneumonia: The role for pneurnococcal and influenza vaccines SO CLINICS IN CHEST MEDICINE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; PNEUMOCOCCAL POLYSACCHARIDE VACCINE; OBSTRUCTIVE PULMONARY-DISEASE; GUILLAIN-BARRE-SYNDROME; PLACEBO-CONTROLLED TRIAL; HIV-INFECTED PATIENTS; HIGH-RISK; STREPTOCOCCUS-PNEUMONIAE; UNITED-STATES; CAPSULAR POLYSACCHARIDES AB Streptococcus pneumoniae and influenza cause a wide spectrum of illness and result in substantial morbidity and mortality. They are significant public health concerns, and vaccines against both organisms exist. The pneumococcal polysaccharide vaccine has been available in its current form for over 20 years. Nonetheless, definitive evidence from prospective trials of its efficacy is lacking. Experts recommend that patients at high risk for pneumococcal infection and complications from this process be vaccinated. The role for revaccination remains controversial. Traditional influenza vaccine is composed of three virus types and decreases rates of serologically confirmed cases of influenza, hospital admissions for respiratory infection, and mortality. The pneumococcal and influenza vaccines are considered cost-effective options for pneumonia prevention. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20817 USA. RP Shorr, AF (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM afshorr@dnamail.com NR 88 TC 7 Z9 9 U1 1 U2 5 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0272-5231 J9 CLIN CHEST MED JI Clin. Chest Med. PD MAR PY 2005 VL 26 IS 1 BP 123 EP + DI 10.1016/j.ccm.2004.10.003 PG 13 WC Respiratory System SC Respiratory System GA 913RD UT WOS:000228169800016 PM 15802174 ER PT J AU Conti, G AF Conti, G TI Why computer scientists should attend hacker conferences SO COMMUNICATIONS OF THE ACM LA English DT Editorial Material C1 US Mil Acad, W Point, NY 10996 USA. RP Conti, G (reprint author), US Mil Acad, W Point, NY 10996 USA. EM conti@acm.org NR 1 TC 8 Z9 8 U1 0 U2 0 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 1515 BROADWAY, NEW YORK, NY 10036 USA SN 0001-0782 J9 COMMUN ACM JI Commun. ACM PD MAR PY 2005 VL 48 IS 3 BP 23 EP 24 DI 10.1145/1047671.1047694 PG 2 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA 908NI UT WOS:000227793300009 ER PT J AU Scafetta, N West, BJ AF Scafetta, N West, BJ TI Multiscaling compapative analysis of time seples and geophysical phenomena SO COMPLEXITY LA English DT Article DE scaling exponents; geophysical systems; scaling coefficient; Levy-walk time series; fractal Gaussian time series AB Different methods are used to determine the scaling exponents associated with a time series describing a complex dynamical process, such as those observed in geophysical systems. Many of these methods are based on the numerical evaluation of the variance of a diffusion process whose step increments are generated by the data. An alternative method focuses on the direct evaluation of the scaling coefficient of the Shannon entropy of the same diffusion distribution. The combined use of these methods can efficiently distinguish between fractal Gaussian and Levy-walk time series and help to discern between alternative underling complex dynamics. (c) 2005 Wiley Periodicals, Inc. C1 Duke Univ, Dept Phys, Durham, NC 27708 USA. USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. RP Scafetta, N (reprint author), Duke Univ, Dept Phys, Durham, NC 27708 USA. EM nicola.scafetta@duke.edu RI West, Bruce/E-3944-2017; OI Scafetta, Nicola/0000-0003-0967-1911 NR 27 TC 20 Z9 20 U1 0 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1076-2787 J9 COMPLEXITY JI Complexity PD MAR-APR PY 2005 VL 10 IS 4 BP 51 EP 56 DI 10.1002/cplx.20076 PG 6 WC Mathematics, Interdisciplinary Applications; Multidisciplinary Sciences SC Mathematics; Science & Technology - Other Topics GA 917NJ UT WOS:000228469000005 ER PT J AU Zhao, Y Karypis, G AF Zhao, Y Karypis, G TI Hierarchical clustering algorithms for document datasets SO DATA MINING AND KNOWLEDGE DISCOVERY LA English DT Article DE hierarchical clustering; criterion function; constrained agglomerative clustering; data mining AB Fast and high-quality document clustering algorithms play an important role in providing intuitive navigation and browsing mechanisms by organizing large amounts of information into a small number of meaningful clusters. In particular, clustering algorithms that build meaningful hierarchies out of large document collections are ideal tools for their interactive visualization and exploration as they provide data-views that are consistent, predictable, and at different levels of granularity. This paper focuses on document clustering algorithms that build such hierarchical solutions and (i) presents a comprehensive study of partitional and agglomerative algorithms that use different criterion functions and merging schemes, and (ii) presents a new class of clustering algorithms called constrained agglomerative algorithms, which combine features from both partitional and agglomerative approaches that allows them to reduce the early-stage errors made by agglomerative methods and hence improve the quality of clustering solutions. The experimental evaluation shows that, contrary to the common belief, partitional algorithms always lead to better solutions than agglomerative algorithms; making them ideal for clustering large document collections due to not only their relatively low computational requirements, but also higher clustering quality. Furthermore, the constrained agglomerative methods consistently lead to better solutions than agglomerative methods alone and for many cases they outperform partitional methods, as well. C1 Univ Minnesota, Dept Comp Sci & Engn, Minneapolis, MN 55455 USA. Digital Technol Ctr, Minneapolis, MN 55455 USA. Army HPC Res Ctr, Minneapolis, MN 55455 USA. RP Univ Minnesota, Dept Comp Sci & Engn, Minneapolis, MN 55455 USA. EM yzhao@cs.umn.edu; karypis@cs.umn.edu NR 46 TC 168 Z9 181 U1 2 U2 15 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1384-5810 EI 1573-756X J9 DATA MIN KNOWL DISC JI Data Min. Knowl. Discov. PD MAR PY 2005 VL 10 IS 2 BP 141 EP 168 DI 10.1007/s10618-005-0361-3 PG 28 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems SC Computer Science GA 924HV UT WOS:000228970700003 ER PT J AU Polonsky, WH Fisher, L Earles, J Dudl, RJ Lees, J Mullan, J Jackson, RA AF Polonsky, WH Fisher, L Earles, J Dudl, RJ Lees, J Mullan, J Jackson, RA TI Assessing psychosocial distress in diabetes - Development of the Diabetes Distress Scale SO DIABETES CARE LA English DT Article ID QUALITY-OF-LIFE; PROBLEM AREAS; MARITAL RELATIONSHIP; INTENSIVE TREATMENT; GLYCEMIC CONTROL; QUESTIONNAIRE; INDIVIDUALS; VALIDITY AB OBJECTIVE - The purpose of this Study was to describe the development of the Diabetes Distress Scale (DDS), a new instrument for the assessment of diabetes-related emotional distress, based on four independent patient samples. RESEARCH DESIGN AND METHODS - in consultation with patients and professionals from multiple disciplines, a preliminary scale of 28 items was developed, based a priori on four distress-related domains: emotional burden subscale, physician-related distress subscale, regimen-related distress subscale, and diabetes-related interpersonal distress. The new instrument was included in a larger battery of questionnaires used in diabetes studies at four diverse Sites: waiting room at a primary care clinic (n = 200), waiting room at a diabetes specialty clinic (n = 179), a diabetes management Study program (n = 167), and an ongoing diabetes management progam (n = 158). RESULTS - Exploratory factor analyses revealed four factors consistent across sites (involving 17 of the 28 items) that matched the critical content domains identified earlier. The correlation between the 28-item and 17-item scales was very high (r = 0.99). The mean correlation between the 17-item total score (DDS) and the four subscales was high (r = 0.82), but the pattern of interscale correlations suggested that the subscales, although not totally independent, tapped into relatively different areas of diabetes-related distress. Internal reliability of the DDS and the four subscales was adequate (alpha > 0.87), and validity coefficients yielded significant linkages with the Center for Epidemiological Studies Depression Scale, meal planning, exercise, and total cholesterol. Insulin users evidenced the highest mean DDS total scores, whereas diet-controlled subjects displayed the lowest scores (P < 0.001). CONCLUSIONS - The DDS has a consistent, generalizable factor structure and good internal reliability and validity across four different clinical sites. The new instrument may serve as a valuable measure of diabetes-related emotional distress for use in research and clinical practice. C1 Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA. Univ Calif San Francisco, Dept Family & Community Med, San Francisco, CA 94143 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. Kaiser Permanente, San Diego, CA USA. USN, Med Ctr, San Diego, CA 92152 USA. Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02115 USA. RP Polonsky, WH (reprint author), CDE,POB 2148, Del Mar, CA 92014 USA. EM whpolonsky@aol.com NR 19 TC 272 Z9 283 U1 4 U2 36 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD MAR PY 2005 VL 28 IS 3 BP 626 EP 631 DI 10.2337/diacare.28.3.626 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 903ME UT WOS:000227429200021 PM 15735199 ER PT J AU Aleksov, A Li, X Govindaraju, N Gobien, JM Wolter, SD Prater, JT Sitar, Z AF Aleksov, A Li, X Govindaraju, N Gobien, JM Wolter, SD Prater, JT Sitar, Z TI Silicon-on-diamond: An advanced silicon-on-insulator technology SO DIAMOND AND RELATED MATERIALS LA English DT Article; Proceedings Paper CT 15th European Conference on Diamond, Diamond-Like Materials, Carbon Nanotubes, Nitrides, and Silicon Carbide CY SEP 12-17, 2004 CL Riva del Garda, ITALY SP Aixtron AG, Diamond Business-Magazine, Elsevier Ltd, Iplas Innovat Plasma Syst GmbH, Roth & Rau AG, Seki Technotron Corp DE silicon-on-diamond (SOD); heaters; IR-imaging; 3D-FE ID HIGHLY ORIENTED DIAMOND; MICROSTRUCTURE; NUCLEATION; DEVICES; BIAS AB Silicon-on-diamond (SOD) technology is proposed as an advanced alternative to conventional silicon-on-insulator (SOI) technology. In SOD, the electrical insulator is diamond, the best thermal conductor in nature. In our SOD concept, the diamond film is highly oriented (HOD), 75-100 mu m thick and serves as an electrical insulator, heat spreader and substrate. In this paper, we focus on the thermal evaluation of SOD with a Si device layer on the nucleation side of the diamond film. The obtained results indicated that SOD can sustain up to 10-times higher power loads than SOL The results were experimentally obtained by R(T) measurements of micro-heaters deposited on the Si device layer and by thermal imaging. 3D finite element thermal simulations using ANSYS confirmed that these numbers are in good agreement with expectations. (c) 2005 Elsevier B.V. All rights reserved. C1 N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. Army Res Off, Res Triangle Pk, NC 27709 USA. RP Aleksov, A (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, 1001 Capability Dr,Rb 1,Rm 215, Raleigh, NC 27695 USA. EM aaleksov@unity.ncsu.edu NR 20 TC 23 Z9 23 U1 1 U2 4 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-9635 J9 DIAM RELAT MATER JI Diam. Relat. Mat. PD MAR-JUL PY 2005 VL 14 IS 3-7 SI SI BP 308 EP 313 DI 10.1016/j.diamond.2005.01.019 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA 935AP UT WOS:000229751400013 ER PT J AU Jenkins, TE Hewitt, AD Walsh, ME Ranney, TA Ramsey, CA Grant, CL Bjella, KL AF Jenkins, TE Hewitt, AD Walsh, ME Ranney, TA Ramsey, CA Grant, CL Bjella, KL TI Representative sampling for energetic compounds at military training ranges SO ENVIRONMENTAL FORENSICS LA English DT Article DE representativeness; representative sampling; energetic compounds; explosives; propellants; sampling ID EXPLOSIVES RESIDUES; SOIL AB Field sampling experiments were conducted at various locations on training ranges at three military installations within North America. The areas investigated included ail anti-tank range firing point, an anti-tank range impact area, all artillery-range firing point, and an artillery-range impact area. The Purpose of this study was to develop practical sampling strategies to reliably estimate mean concentrations of residues from munitions found in surface soil at various types of live-fire training ranges. The ranges studied differ in the types of energetic residues deposited and the mode of deposition. In most cases, the major source zones for these residues are the top two or three centimeters of soil. Multi-increment sampling was used to reduce the variance between field sample replicates and to enhance sample representativeness. Based on these criteria the results indicate that a single or a few discrete samples do not provide representative data for these types of sites. However, samples built from at least 25 increments provided data that was sufficiently representative to allow for the estimation of energetic residue mass loading in surface soils and to characterize the training activity at a given location. thereby addressing two objectives that frequently are common to both environmental and forensic investigations. C1 USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Sci & Technol Corp, Hanover, NH USA. EnviroStat, Ft Collins, CO USA. Univ New Hampshire, Dept Chem, Durham, NH 03824 USA. RP Jenkins, TE (reprint author), USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. EM thomas.F.Jenkins@cr102.usace.army.mil NR 25 TC 24 Z9 24 U1 1 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1527-5922 J9 ENVIRON FORENSICS JI Environ. Forensics PD MAR PY 2005 VL 6 IS 1 BP 45 EP 55 DI 10.1080/15275920590913912 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA 910SL UT WOS:000227952400010 ER PT J AU Ramsey, CA Hewitt, AD AF Ramsey, CA Hewitt, AD TI A methodology for assessing sample representativeness SO ENVIRONMENTAL FORENSICS LA English DT Article DE representativeness; quality control; data quality objectives; sample plan design ID SOIL AB Assessing sample representativeness is a critical component of any environmental investigation and should be performed before any conclusions are reached. If the samples are not representative, any conclusions or decisions will be incorrect. A complete understanding of the data quality objective process, sample plan design, sample plan implementation, and quality control is required to assess sample representativeness. This article presents a methodology for the evaluation of sample representativeness. C1 EnviroStat Inc, Ft Collins, CO 80522 USA. USA, Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA. RP Ramsey, CA (reprint author), EnviroStat Inc, POB 636, Ft Collins, CO 80522 USA. EM chuck@envirostat.org NR 15 TC 17 Z9 17 U1 2 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1527-5922 J9 ENVIRON FORENSICS JI Environ. Forensics PD MAR PY 2005 VL 6 IS 1 BP 71 EP 75 DI 10.1080/15275920590913877 PG 5 WC Environmental Sciences SC Environmental Sciences & Ecology GA 910SL UT WOS:000227952400013 ER PT J AU Cooke, WH Carter, JR AF Cooke, WH Carter, JR TI Strength training does not affect vagal-cardiac control or cardiovagal baroreflex sensitivity in young healthy subjects SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE weight training; arterial baroreflex; heart rate variability; frequency domain analysis ID BLOOD-PRESSURE REGULATION; ENDURANCE EXERCISE; CARDIOVASCULAR REGULATION; GENDER-DIFFERENCES; AUTONOMIC CONTROL; HEART-RATE; TOLERANCE; RESPONSES; MECHANISMS; LBNP AB The purpose of this study was to test the hypothesis that high-intensity strength training increases vagal-cardiac control and cardiovagal baroreflex sensitivity. Twenty-two subjects [age 22 (0.8) years] were assigned to either strength training (ST, n = 12) or control (CON, n = 10) groups. Subjects in the ST group trained each major muscle group 3 days per week for 8 weeks with three sets of 10 repetitions and 2-min rest periods. Resistance was increased progressively when possible. Subjects in the CON group were active recreationally but did not lift weights. Before and after training, resting arterial pressure was measured with an automated sphygmomanometer, and ECG, respiratory rate, and finger photoplethysmographic arterial pressures were recorded with subjects supine and breathing at a set rate (0.25 Hz) for 5 min. Data were analyzed in both time and frequency domains. Arterial baroreflex sensitivity was estimated with the sequence method and cross-spectral transfer function analysis of systolic pressures and R-R intervals. Training increased whole-body muscular strength and decreased arterial blood pressure at rest (the exercise and pressure data have been published elsewhere). R-R intervals and standard deviations, and R-R interval spectral power at the respiratory frequency were unaffected by training. Similarly, training did not affect respiratory or low-frequency systolic pressure spectral power or cardiovagal baroreflex sensitivity. Although evidence supports beneficial cardiovascular adaptations to resistance training, our results demonstrate that resistance training does not affect vagal-cardiac control or cardiovagal baroreflex sensitivity in young healthy subjects. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA. RP Cooke, WH (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave Bld 3611, Ft Sam Houston, TX 78234 USA. EM william.cooke@amedd.army.mil NR 34 TC 33 Z9 36 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD MAR PY 2005 VL 93 IS 5-6 BP 719 EP 725 DI 10.1007/s00421-004-1243-x PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 918EM UT WOS:000228525100029 PM 15517338 ER PT J AU Deem, SL Maisels, F Robbins, RG AF Deem, SL Maisels, F Robbins, RG TI Necropsy and parasitic findings from an adult forest buffalo (Syncerus caffer nanus) found dead in the Republic of Congo SO EUROPEAN JOURNAL OF WILDLIFE RESEARCH LA English DT Article DE endoparasites; ectoparasites; forest buffalo; Nouabale-Ndoki National Park; Republic of Congo; Syncerus caffer nanus ID LEOPARD AB A field necropsy was performed on a recently dead adult forest buffalo, Syncerus caffer nanus, found in the Nouabale-Ndoki National Park, Republic of Congo. Based on the gross and histological lesions, the cause of death was determined to be conspecific fighting. Ectoparasites collected from this forest buffalo were Amblyomma sp. (larvae) and Rhipicephalus ziemanni Neumann. Endoparasites collected included a paramphistomid trematode, Carmyerius gregarius, and oocysts of Eimeria spp., paramphistomid eggs (presumably from C. gregarius), metastrongylid lungworm larvae, and strongylid eggs. Parasitic findings from this forest buffalo were compared to previous reports from savanna and forest buffalo. C1 Wildlife Conservat Soc, Field Vet Program, Bronx, NY 10460 USA. Wildlife Conservat Soc, Int Program, Bronx, NY 10460 USA. Walter Reed Army Med Ctr, AFPMB, Washington, DC 20307 USA. RP Deem, SL (reprint author), Smithsonians Natl Zool Pk, 3001 Connecticut Ave, Washington, DC 20008 USA. EM deems@si.edu RI Maisels, Fiona/E-7382-2015 OI Maisels, Fiona/0000-0002-0778-0615 NR 18 TC 3 Z9 3 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1612-4642 J9 EUR J WILDLIFE RES JI Eur. J. Wildl. Res. PD MAR PY 2005 VL 51 IS 1 BP 60 EP 62 DI 10.1007/s10344-004-0072-x PG 3 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 907GG UT WOS:000227703300009 ER PT J AU Neithardt, AB Segars, JH Hennessy, S James, AN McKeeby, JL AF Neithardt, AB Segars, JH Hennessy, S James, AN McKeeby, JL TI Embryo afterloading: a refinement in embryo transfer technique that may increase clinical pregnancy SO FERTILITY AND STERILITY LA English DT Article; Proceedings Paper CT 59th Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 11-15, 2003 CL SAN ANTONIO, TX SP Amer Soc Reprod Med DE embryo transfer; technique; IVF-ET; pregnancy rate ID IN-VITRO FERTILIZATION; INVITRO FERTILIZATION; OVARIAN STIMULATION; TRANSFER CATHETER; LUTEAL-PHASE; RATES; IMPACT; RECOMBINANT; IMPROVES; CYCLE AB Objective: Given the importance of ET technique during assisted reproductive technology cycles, we evaluated the effect of embryo afterloading subsequent to placement of the ET catheter on pregnancy rates vs. a standard direct Et. Design: Retrospective cohort analysis. Setting: University-based assisted reproductive technology program. Patient(s): Patients undergoing a fresh nondonor day 3 ET by a single provider over a 1-year period. Intervention(s): None. Main Outcome Measure(s): Clinical pregnancy. Result(s): One hundred twenty-seven patients met inclusion criteria, and the overall pregnancy rate was 46.5%. There was no difference between the two groups with respect to age, basal FSH, or number of embryos transferred. The ET method used was at the discretion of the provider. There was no difference between the two groups in the presence of blood on the transfer catheter. However, there were significantly more transfer catheters with mucus contamination in the direct transfer group (25.58% vs. 5.95%). The clinical pregnancy rate in the group with ET using the afterloading technique was higher than in the direct ET group (52.4% vs. 34.9%). Conclusion(s): There was a trend toward an increase in pregnancy rate when an embryo afterloading technique was used. A prospective randomized trial is needed to examine this issue. (c) 2005 by American Society for Reproductive Medicine. C1 NICHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. ATR Inst Washington, Washington, DC USA. Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. Shady Grove Fertil Reprod Sci Ctr, Rockville, MD USA. RP Neithardt, AB (reprint author), NICHD, Pediat & Reprod Endocrinol Branch, NIH, Blgd 10,Room 9D-42,9000 Rockville Pike, Bethesda, MD 20892 USA. EM neithara@mail.nih.gov FU Intramural NIH HHS [Z99 HD999999] NR 26 TC 30 Z9 30 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD MAR PY 2005 VL 83 IS 3 BP 710 EP 714 DI 10.1016/j.fertnstert.2004.08.022 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 906JS UT WOS:000227637600029 PM 15749502 ER PT J AU Mendis, C Das, R Hammamieh, R Royaee, A Yang, D Peel, S Jett, M AF Mendis, C Das, R Hammamieh, R Royaee, A Yang, D Peel, S Jett, M TI Transcriptional response signature of human lymphoid cells to staphylococcal enterotoxin B SO GENES AND IMMUNITY LA English DT Article DE gene expression profile; genomic markers; shock-inducing toxins; differential gene expression; human peripheral blood mononuclear cells ID SEVERE SEPSIS; PROLIFERATION; SUPERANTIGEN; HYPOXIA; AUREUS; SYSTEM; O-2 AB Two shock-inducing toxins that result in similar eventual outcome of disease were studied to determine host gene expression responses, for correlation of both similar and unique gene patterns. We initially used differential display (DD)-PCR and identified 859 cDNA fragments that were differentially expressed after 16 h of in vitro exposure of human peripheral blood mononuclear cells (PBMC) to staphylococcal enterotoxin B (SEB). Upon further examination using custom cDNA microarrays and RT-PCR analysis, we found unique set of genes to each toxin (SEB or lipopolysaccharide (LPS)), especially at early time periods. By 16 h, there was a convergence of some gene expression responses and many of those genes code for proteins such as proteinases, transcription factors, vascular tone regulators, and respiratory distress. In an attempt to replicate the findings in vivo, monkeys were challenged with SEB and the resultant gene expression responses indicated a pattern typical of SEB exposure when compared to LPS, with a similar outcome. We provide evidence that vastly diverse global gene analysis techniques used in unison can not only effectively identify pathogen-specific genomic markers and provide a solid foundation to mechanistic insights but also explain some of the toxin-related symptoms through gene functions. C1 Univ Wisconsin, Dept Chem & Engn Phys, Platteville, WI 53818 USA. Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. Georgetown Univ, Dept Chem, Washington, DC 20057 USA. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. RP Mendis, C (reprint author), Univ Wisconsin, Dept Chem & Engn Phys, Platteville, WI 53818 USA. EM mendisc@uwplatt.edu RI Yang, David/A-7294-2009 NR 29 TC 9 Z9 10 U1 0 U2 5 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1466-4879 J9 GENES IMMUN JI Genes Immun. PD MAR PY 2005 VL 6 IS 2 BP 84 EP 94 DI 10.1038/sj.gene.6364160 PG 11 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA 902CQ UT WOS:000227329400002 PM 15674373 ER PT J AU Okuno, T Kojima, M Hata, I Sliney, DH AF Okuno, T Kojima, M Hata, I Sliney, DH TI Temperature rises in the crystalline lens from focal irradiation SO HEALTH PHYSICS LA English DT Article DE optics; health effects; radiation; nonionizing; lasers ID INFRARED RADIATION; RABBIT EYES; MODEL AB Many types of ophthalmic instruments produce a concentrated focal irradiance in the lens. Instruments that illuminate large areas of the retina-known as "Maxwellian-view," are but one example, and there are concerns about the potential hazards associated with this optical system. The transfer of the heat generated in the human eye in Maxwellian-view illumination or similar focal-beam situations was simulated using a mathematical model to determine the temperature elevations induced in the human eye. The maximum temperature rise in the lens region was examined to quantitatively assess the potential thermal hazard to the lens. It was shown that Maxwellian-view illumination or similar focal-beam situations can cause thermal injury to the lens under certain conditions, and that this hazard is greater for incident wavelengths of about 320-420 nm than for longer wavelengths. The risk of thermal injury increases as exposure duration increases, and the risk tends to increase as the beam waist diameter or Maxwellian-view angle decreases. C1 Natl Inst Ind Hlth, Tama Ku, Kawasaki, Kanagawa 2148585, Japan. Kanazawa Med Univ, Dept Ophthalmol, Uchinada, Ishikawa 9200293, Japan. USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Okuno, T (reprint author), Natl Inst Ind Hlth, Tama Ku, 6-21-1 Nagao, Kawasaki, Kanagawa 2148585, Japan. EM okuno@niih.go.jp NR 14 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAR PY 2005 VL 88 IS 3 BP 214 EP 222 DI 10.1097/01.HP.0000146581.72675.aa PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 898CR UT WOS:000227054100002 PM 15706141 ER PT J AU Vann, RD Pollock, NW Pieper, CF Murdoch, DR Muza, SR Natoli, MJ Wang, LY AF Vann, RD Pollock, NW Pieper, CF Murdoch, DR Muza, SR Natoli, MJ Wang, LY TI Statistical models of acute mountain sickness SO HIGH ALTITUDE MEDICINE & BIOLOGY LA English DT Article; Proceedings Paper CT 14th International Hypoxia Symposium CY FEB 23-27, 2005 CL Lake Louise, CANADA DE altitude; probability; acclimatization; acetazolamide; Lake Louise ID HIGH-ALTITUDE ILLNESS; SYMPTOMS; ASCENT; ACETAZOLAMIDE; EXPOSURE; HYPOXIA; EVEREST; NEPAL AB Acute mountain sickness (AMS) is caused by exposure to altitudes exceeding 2500 m and often resolves by acclimatization without further ascent. Statistical models of AMS score and the probability of an AMS diagnosis were developed to allow the combination of dissimilar exposures for simultaneous analysis. The study population was 302 trekkers from a previous investigation who provided self-reported symptoms upon arrival at 3840 m during hikes through altitudes of 1500 to 6200 m. AMS score (Hackett scale) was estimated by linear regression and the probability of an AMS diagnosis (Lake Louise criteria) by logistic regression. AMS score or probability was significantly associated with exposure day and altitude. Increased altitude over the prior 3 days resulted in higher estimated AMS score or probability and decreased altitude in lower score or probability. The odds ratio (OR) of AMS was 3.6 if not on acetazolamide. Females appeared slightly more susceptible than males (1.5 OR). The approach offers the advantages of (1) improved statistical power by combining exposures, (2) insight into the dose-response relationship of altitude exposure and AMS risk, (3) quantitative tests for the significance of factors that might affect AMS susceptibility, and (4) practical tools to track individual climbers and plan operational ascents. C1 Duke Univ, Med Ctr, Dept Anesthesiol, Ctr Hyperbar Med & Evolut Physiol, Durham, NC 27710 USA. Duke Univ, Med Ctr, Ctr Aging, Dept Biostat & Bioinformat, Durham, NC 27710 USA. Univ Otago, Dept Pathol, Christchurch Sch Med & Hlth Sci, Christchurch, New Zealand. USA, Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. Duke Univ, Med Ctr, Sch Med, Durham, NC 27710 USA. RP Vann, RD (reprint author), Duke Univ, Med Ctr, Dept Anesthesiol, Ctr Hyperbar Med & Evolut Physiol, POB 3823, Durham, NC 27710 USA. EM rvann@dan.duke.edu NR 30 TC 7 Z9 7 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1527-0297 J9 HIGH ALT MED BIOL JI High Alt. Med. Biol. PD SPR PY 2005 VL 6 IS 1 BP 32 EP 42 DI 10.1089/ham.2005.6.32 PG 11 WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences GA 909LZ UT WOS:000227862700004 PM 15772498 ER PT J AU Krishnaswami, S Agarwal, A Ryu, SH Capell, C Richmond, J Palmour, J Balachandran, S Chow, TP Bayne, S Geil, B Jones, K Scozzie, C AF Krishnaswami, S Agarwal, A Ryu, SH Capell, C Richmond, J Palmour, J Balachandran, S Chow, TP Bayne, S Geil, B Jones, K Scozzie, C TI 1000-V, 30-A 4H-SiC BJTs with high current gain SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE 4H-SiC; current gain; high-speed switching; power BJT ID BIPOLAR JUNCTION TRANSISTORS; POWER AB This paper presents the development of 1000 V, 30 A bipolar junction transistor (BJT) with high dc current gain in 4H-SiC. BJT devices with an active area of 3 x 3 mm(2) showed a forward on-current of 30 A, which corresponds to a current density of 333 A/cm(2), at a forward voltage drop of 2 V. A common-emitter current gain of 40, along with a low specific on-resistance of 6.0 mOmega.cm(2) as observed at room temperature. These results show significant improvement over state-of-the-art. High temperature current-voltage characteristics were also performed on the large-area bipolar junction transistor device. A collector current of 10 A is observed at V-CE, = 2 V and I-B = 600 mA at 225 degreesC. The on-resistance increases to 22.5 mOmega.cm(2) at higher temperatures, while the de current gain decreases to 30 at 275 degreesC. A sharp avalanche behavior was observed at a collector voltage of 1000 V. Inductive switching measurements at room temperature with a power supply voltage of 500 V show fast switching with a turn-off time of about 60 ns and a turn-on time of 32 ns, which is a result of the low resistance in the base. C1 Cree Inc, Durham, NC 27703 USA. Rensselaer Polytech Inst, Troy, NY 12180 USA. Army Res Lab, Adelphi, MD 20783 USA. RP Cree Inc, Durham, NC 27703 USA. NR 11 TC 49 Z9 52 U1 2 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD MAR PY 2005 VL 26 IS 3 BP 175 EP 177 DI 10.1109/LED.2004.842731 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 901DF UT WOS:000227262500017 ER PT J AU Zhang, JH Alexandrov, P Zhao, JH Burke, T AF Zhang, JH Alexandrov, P Zhao, JH Burke, T TI 1677 V, 5.7 m Omega center dot cm(2) 4H-SiC BJTs SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE biliolar junction transistors (BJTs); power transistors; silicon carbide ID BIPOLAR JUNCTION TRANSISTORS AB This letter reports the development of a high-performance power 4H-SiC bipolar junction transistor (BJT) with, simultaneously, a high blocking voltage and a low specific on-resistance (RSP-ON). A single BJT cell with an active area of 0.61 mm(2) achieves an open base collector-to-emitter blocking voltage (V-ceo) of 1677 V and conducts up to 3.2 A at a forward voltage drop of V-CE = 3.0 V, corresponding to a low RSP-ON of 5.7 mOmega . cm(2) up to Jc= 525 A/cm(2) and a record high value of V-B(2)/RSP-ON of 493 MW/cm(2). C1 Rutgers State Univ, SiCLAB, Elect & Comp Engn Dept, Piscataway, NJ 08854 USA. United Silicon Carbide Inc, New Brunswick Techonol Ctr, New Brunswick, NJ 08901 USA. US Army TACOM, Warren, MI 48397 USA. RP Rutgers State Univ, SiCLAB, Elect & Comp Engn Dept, Piscataway, NJ 08854 USA. NR 11 TC 8 Z9 8 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD MAR PY 2005 VL 26 IS 3 BP 188 EP 190 DI 10.1109/LED.2005.843928 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 901DF UT WOS:000227262500021 ER PT J AU Power, EM Trope, RL AF Power, EM Trope, RL TI Averting security missteps in outsourcing SO IEEE SECURITY & PRIVACY LA English DT Article C1 US Mil Acad, Dept Law, W Point, NY USA. EM michael.power@gowlings.com; roland.trope@verizon.net RI Sawhney, Davinder/A-5736-2010 NR 5 TC 2 Z9 2 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD MAR-APR PY 2005 VL 3 IS 2 BP 70 EP 73 DI 10.1109/MSP.2005.36 PG 4 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 912PR UT WOS:000228092100013 ER PT J AU Ghogho, M McLernon, D Alameda-Hernandez, E Swami, A AF Ghogho, M McLernon, D Alameda-Hernandez, E Swami, A TI Channel estimation and symbol detection for block transmission using data-dependent superimposed training SO IEEE SIGNAL PROCESSING LETTERS LA English DT Article DE block transmission; estimation; multipath channels; superimposed training AB We address the problem of frequency-selective channel estimation and symbol detection using superimposed training. The superimposed training consists of the sum of a known sequence and a data-dependent sequence that is unknown to the receiver. The data-dependent sequence cancels the effects of the unknown data on channel estimation. The performance of the proposed approach is shown to significantly outperform existing methods based on superimposed training (ST). C1 Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. USA, Res Lab, Adelphi, MD 20783 USA. RP Ghogho, M (reprint author), Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. RI Alameda-Hernandez, Enrique/L-9171-2014 OI Alameda-Hernandez, Enrique/0000-0001-7759-129X NR 8 TC 101 Z9 108 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1070-9908 J9 IEEE SIGNAL PROC LET JI IEEE Signal Process. Lett. PD MAR PY 2005 VL 12 IS 3 BP 226 EP 229 DI 10.1109/LSP.2004.842283 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA 899FO UT WOS:000227130500015 ER PT J AU Xu, FL Liu, X Fujimura, K AF Xu, FL Liu, X Fujimura, K TI Pedestrian detection and tracking with night vision SO IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS LA English DT Article; Proceedings Paper CT 6th IEEE International Conference on Intelligent Transportation Systems CY OCT 12-15, 2003 CL SHANGHAI, PEOPLES R CHINA SP IEEE Council Intelligent Transportat Syst, Chinese Acad Sci, Key Lab Complex Syst & Intelligence Sci DE blob matching; infrared video; Kalman filter; mean shift tracking; motion estimation; pedestrian detection; support vector machine (SVM); tracking ID MOTION DETECTION; SYSTEM AB This paper presents a method for pedestrian detection and tracking using a single night-vision video camera installed on the vehicle. To deal with the nonrigid nature of human appearance on the road, a two-step detection/tracking method is proposed. The detection phase is performed by a support vector machine (SVM) with size-normalized pedestrian candidates and the tracking phase is a combination of Kalman filter prediction and mean shift tracking. The detection phase is further strengthened by information obtained by a road-detection module that provides key information for pedestrian validation. Experimental comparisons (e.g., grayscale SVM recognition versus binary SVM recognition and entire-body detection versus upper-body detection) have been carried out to illustrate the feasibility of our approach. C1 Leica Geosyst, Atlanta, GA 30329 USA. Ohio State Univ, Geodet Sci Dept, Columbus, OH 43210 USA. USA, Honda Res Inst, Mountain View, CA 94041 USA. RP Xu, FL (reprint author), Leica Geosyst, Atlanta, GA 30329 USA. EM Fengliang.Xu@gis.leica-geosystems.com; xliu.427@osu.edu; kfujimura@hra.com NR 38 TC 134 Z9 156 U1 3 U2 29 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1524-9050 J9 IEEE T INTELL TRANSP JI IEEE Trans. Intell. Transp. Syst. PD MAR PY 2005 VL 6 IS 1 BP 63 EP 71 DI 10.1109/TITS.2004.838222 PG 9 WC Engineering, Civil; Engineering, Electrical & Electronic; Transportation Science & Technology SC Engineering; Transportation GA 903CA UT WOS:000227401800008 ER PT J AU Zhou, WM Blasche, G AF Zhou, WM Blasche, G TI Injection-locked dual opto-electronic oscillator with ultra-low phase noise and ultra-low spurious level SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE injection locked; opto-electronic oscillator (OEO); phase noise; spurious level ID MICROWAVE AB We report a new injection-locked dual opto-electronic oscillator (OEO) that uses a long optical fiber loop master oscillator to injection lock into a short-loop signal-mode slave oscillator, which showed substantial improvements in reducing the phase noise and spurs compared to current state-of-the-art multiloop OEOs operating at 10 GHz. Preliminary phase-noise measurement indicated approximately 140-dB reduction of the spurious level. C1 USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. Boston Univ, Dept Phys, Boston, MA 02215 USA. RP Zhou, WM (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM wzhou@arl.army.mil; gblasche@alum.bu.edu NR 11 TC 89 Z9 97 U1 2 U2 16 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD MAR PY 2005 VL 53 IS 3 BP 929 EP 933 DI 10.1109/TMTT.2004.842489 PN 1 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA 904GV UT WOS:000227485000016 ER PT J AU Adler, ED Calcatera, MC Luy, JF Palmer, WD Purdy, DS AF Adler, ED Calcatera, MC Luy, JF Palmer, WD Purdy, DS TI Special issue on multifunctional RF systems - Guest editorial SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Editorial Material C1 USA, Res Lab, Millimeter Wave Branch, Adelphi, MD 20783 USA. USAF, Res Lab, Wright Patterson AFB, Wright Patterson AFB, OH 45433 USA. DaimlerChrysler Res Ctr, Inline Inspect Dept, D-89081 Ulm, Germany. USA, Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27709 USA. US Off Naval Res, Div Elect, Arlington, VA 22217 USA. RP Adler, ED (reprint author), USA, Res Lab, Millimeter Wave Branch, Adelphi, MD 20783 USA. RI Palmer, William/E-2296-2012 NR 0 TC 1 Z9 1 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD MAR PY 2005 VL 53 IS 3 BP 1005 EP 1008 DI 10.1109/TMTT.2005.843470 PN 2 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA 904GX UT WOS:000227485200001 ER PT J AU Van der Schalie, WH Gargan, TP Shedd, TR Widder, MW AF Van der Schalie, W. H. Gargan, T. P., II Shedd, T. R. Widder, M. W. TI The use of animal cell-based toxicity sensors for water testing SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. Geocenters Inc, USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. EM william.vanderschalie@det.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2005 VL 41 BP 3A EP 3A PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA V44IC UT WOS:000202995400009 ER PT J AU Rastogi, VK Cheng, TC AF Rastogi, Vipin K. Cheng, Tu-chen TI Approaches for developing novel Probes/Loci for PCR-based detection of pathogens SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 USA, Edgewood Chem & Biol Ctr, MAP Team, R&T Directorate, Aberdeen Proving Ground, MD 21010 USA. Geocenters Inc, Gunpower Club, Aberdeen Proving Ground, MD 21010 USA. EM vipin.rastogi@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2005 VL 41 BP 9A EP 9A PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA V44IC UT WOS:000202995400031 ER PT J AU Magill, AJ AF Magill, AJ TI Cutaneous leishmaniasis in the returning traveler SO INFECTIOUS DISEASE CLINICS OF NORTH AMERICA LA English DT Review ID SODIUM STIBOGLUCONATE PENTOSTAM; IMPORTED MUCOCUTANEOUS LEISHMANIASIS; METHYLBENZETHONIUM CHLORIDE OINTMENT; CONTROLLED CLINICAL-TRIAL; UNITED-STATES MILITARY; DOUBLE-BLIND TRIAL; MUCOSAL LEISHMANIASIS; TOPICAL TREATMENT; MEGLUMINE ANTIMONIATE; OLD-WORLD AB Infection with protozoan parasites of the genus Leishmania leads to a wide variety of clinical disease syndromes called leishmaniasis, or more appropriately the leishmaniases. The three major clinical syndromes are cutaneous leishmaniasis, mucosal leishmaniasis, and visceral leishmaniasis. All three of these syndromes have been documented in returning travelers. This article focuses on cutaneous leishmaniasis with some comment on mucosal leishmaniasis. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Magill, AJ (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM alan.magill@na.amedd.army.mil NR 128 TC 28 Z9 28 U1 0 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0891-5520 J9 INFECT DIS CLIN N AM JI Infect. Dis. Clin. North Am. PD MAR PY 2005 VL 19 IS 1 BP 241 EP + DI 10.1016/j.idc.2004.11.005 PG 28 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 903TO UT WOS:000227448700015 PM 15701556 ER PT J AU Tis, JE Reiter, FO Saleh, M AF Tis, JE Reiter, FO Saleh, M TI Treatment of a supracondylar femoral nonunion in a patient with osteoporosis by square osteotomy and acute shortening SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article ID INTERNAL-FIXATION; FRACTURES; FEMUR C1 Univ Sheffield, No Gen Hosp, Orthopaed & Trauma Surg Res Grp, Sheffield S5 7AU, S Yorkshire, England. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Hannover Med Sch, D-3000 Hannover, Germany. RP Tis, JE (reprint author), 4216 Gelding Lane, Olney, MD 20832 USA. EM jtis1@aol.com NR 10 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD MAR PY 2005 VL 36 IS 3 BP 454 EP 457 DI 10.1016/j.injury.2004.11.009 PG 4 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 905XP UT WOS:000227605000017 PM 15710166 ER PT J AU Bergmann-Leitner, ES Scheiblhofer, S Duncan, EH Leitner, WW Chen, D Angov, E Khan, F Williams, JL Winter, DB Thalhamer, J Lyon, JA Tsokos, GC AF Bergmann-Leitner, ES Scheiblhofer, S Duncan, EH Leitner, WW Chen, D Angov, E Khan, F Williams, JL Winter, DB Thalhamer, J Lyon, JA Tsokos, GC TI C3d binding to the circumsporozoite protein carboxy-terminus deviates immunity against malaria SO INTERNATIONAL IMMUNOLOGY LA English DT Article DE complement; host defense; malaria; T lymphocytes ID B-CELL RESPONSE; PLASMODIUM-BERGHEI; MOLECULAR ADJUVANT; PROTECTIVE IMMUNITY; FUSION PROTEINS; COMPLEMENT; ANTIBODY; DNA; SPOROZOITES; EXPRESSION AB The immunogenicity of recombinant protein or anti-viral DNA vaccines can be significantly improved by the addition of tandem copies of the complement fragment C3d. We sought to determine if the efficacy of a circumsporozoite protein (CSP)-based DNA vaccine delivered to mouse skin by gene gun was improved by using this strategy. Instead, we found that C3d suppressed the protective immunity against Plasmodium berghei malaria infection and deviated immunity, most notably by suppressing the induction of antibodies specific for the CSP C-terminal flanking sequence and by suppressing the induction of CSP-specific IL-4-producing spleen cells. We further showed that C3d bound to the C-terminal flanking sequence of the CSP, which may explain the immune deviation observed in CS/C3d chimeric antigen. We have thus identified C3d-mediated epitope masking and shifting of both the humoral and cellular immune responses as a potential novel escape mechanism, which plasmodia may use to divert the induction of protective immunity. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. Salzburg Univ, Inst Chem & Biochem, Immunol Grp, A-5020 Salzburg, Austria. NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA. RP Tsokos, GC (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. EM gtsokos@usuhs.mil RI Bergmann-Leitner, Elke/B-3548-2011; Leitner, Wolfgang/F-5741-2011; Weiss, Richard/N-7279-2013; Thalhamer, Josef/E-5787-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Leitner, Wolfgang/0000-0003-3125-5922; Weiss, Richard/0000-0003-3185-7253; Thalhamer, Josef/0000-0003-2285-6400 FU NIAID NIH HHS [R03 AI053463] NR 42 TC 27 Z9 28 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0953-8178 J9 INT IMMUNOL JI Int. Immunol. PD MAR PY 2005 VL 17 IS 3 BP 245 EP 255 DI 10.1093/intimm/dxh205 PG 11 WC Immunology SC Immunology GA 900WB UT WOS:000227243900004 PM 15710912 ER PT J AU Frances, SP AF Frances, SP TI Potential for horizontal transmission of Orientia tsutsugamushi by chigger mites (Acari : Trombiculidae) SO INTERNATIONAL JOURNAL OF ACAROLOGY LA English DT Article DE Acari; Trombiculidae; rickettsia; scrub typhus; Orientia tsutsugamushi (Hayashi); Mus musculus L; Rattus rattus L; trombiculid mites; transmission ID INFECTED LEPTOTROMBIDIUM-DELIENSE; RICKETTSIA-TSUTSUGAMUSHI; VERTICAL TRANSMISSION; SCRUB TYPHUS; TRANSOVARIAL TRANSMISSION; BORNE RICKETTSIOSIS; THAILAND; ECOLOGY; ORCHARD; BANGKOK AB Experiments to study the potential for horizontal transmission of the rickettsia, Orientia tsutsugamushi (Hayashi) (Rickettsiaceae: Rickettsiales) using laboratory rats and mice are reported. Uninfected larvae of Leptotrombidium deliense Walch (Acari: Trombiculidae) were allowed to engorge on mice that had been infected with O. tsutsugamushi either by inoculation of cultured rickettsiae or from the bite of naturally infected L. deliense larvae. When mice were infected by inoculation with cultured rickettsiae it was shown that uninfected larvae acquired O. tsutsugamushi and transtadial transmission of rickettsiae to tritonymphs occurred, but none of the resultant adults passed infection to their progeny. When uninfected L. deliense larvae were placed on mice ten days after infection by larvae, it was not possible to detect O. tsutsugamushi in uninfected larvae, showing that rickettsiae were not acquired during feeding. The progeny of 37 adults, who as larvae fed on these mice, did not transmit rickettsiae to their progeny. In a subsequent experiment, Rattus rattus L. were infected by attachment of a single infected L. deliense. Batches of uninfected L. deliense and Blankaartia acuscutellaris Walch (Acari: Trombiculidae) were placed on infected rats two and six weeks after infection. O. tsutsugamushi was not detected in engorged larvae of either species, suggesting that rickettsiae were not acquired during feeding. The progeny of one of ten B. acuscutellaris were found to be infected with O. tsutsugamushi, but it was not possible to determine if these mites could transmit rickettsiae vertically. It is possible that rickettsiae persisted at an undetectable level in this batch of mites when they developed to adults. These data support previous studies that show horizontal transmission rarely occurs, and would not be epidemiologically important. However the occurrence of horizontal transmission in B. acuscutellaris is noteworthy, and further studies concerning its role as a vector of O. tsutsugamushi are warranted. C1 Armed Forces Res Inst Med Sci, Dept Med Entomol, Bangkok 10400, Thailand. RP Frances, SP (reprint author), Australian Army Malaria Knife, Gallipoli Barracks, Enoggera, Qld 4051, Australia. EM steve.frances@defence.gov.au NR 26 TC 2 Z9 2 U1 0 U2 2 PU INDIRA PUBLISHING HOUSE PI WEST BLOOMFIELD PA P O BOX 250456, WEST BLOOMFIELD, MI 48325-0456 USA SN 0164-7954 J9 INT J ACAROL JI Int. J. Acarol. PD MAR PY 2005 VL 31 IS 1 BP 75 EP 82 PG 8 WC Entomology SC Entomology GA 901FH UT WOS:000227267900009 ER PT J AU Kellogg, KG Patil, R Kallmeyer, AR Dutta, PK AF Kellogg, KG Patil, R Kallmeyer, AR Dutta, PK TI Effect of load rate on notch toughness of glass FRP subjected to moisture and low temperature SO INTERNATIONAL JOURNAL OF OFFSHORE AND POLAR ENGINEERING LA English DT Article DE composite; moisture; low temperature; Izod; Hopkinson bar; notched impact; load rate; fracture ID IMPACT BEHAVIOR AB An investigation was conducted into the effects of moisture, low temperatures and load rate on the parallel-to-the-fiber notched impact toughness of a pultruded glass-fiber reinforced polymer composite. Tests were performed at 2 load rate levels using Izod (low load rate) and Split Hopkinson Pressure Bar (high load rate) impact devices. For each load rate, specimens were tested at 2 moisture levels and 4 temperature levels (25, -5, -25 and -50degreesC). The results reveal that load rate has the greatest influence on fracture sensitivity for a notched specimen; increasing the rate of loading results in increased mean notch toughness values regardless of moisture content or temperature. It was also determined that, as temperatures are reduced below -25degreesC, the mean notch toughness increases for all test groups. At room temperature the effect of moisture is dependent upon the rate of loading. At low load rates, absorbed moisture is beneficial to fracture sensitivity, but at high load rates the absorbed moisture tends to reduce the notch toughness of the composite. A discussion is also provided on the effects of high load rate on the composite strength and stiffness. C1 N Dakota State Univ, Dept Civil Engn & Construct, Fargo, ND 58105 USA. N Dakota State Univ, Dept Mech Engn & Appl Mech, Fargo, ND 58105 USA. USACE Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA. RP Kellogg, KG (reprint author), N Dakota State Univ, Dept Civil Engn & Construct, Fargo, ND 58105 USA. NR 9 TC 2 Z9 2 U1 0 U2 5 PU INT SOC OFFSHORE POLAR ENGINEERS PI CUPERTINO PA PO BOX 189, CUPERTINO, CA 95015-0189 USA SN 1053-5381 J9 INT J OFFSHORE POLAR JI Int. J. Offshore Polar Eng. PD MAR PY 2005 VL 15 IS 1 BP 54 EP 61 PG 8 WC Engineering, Civil; Engineering, Ocean; Engineering, Mechanical SC Engineering GA 904GL UT WOS:000227484000009 ER PT J AU Scobell, A AF Scobell, A TI An orderly, pacific Asia - Or Asia-Pacific powder keg? SO ISSUES & STUDIES LA English DT Article C1 USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. RP Scobell, A (reprint author), USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. EM andrew.scobell@carlisle.army.mil NR 8 TC 0 Z9 0 U1 0 U2 0 PU INST INTERNAT RELATIONS PI MUCHA PA 64 WAN SHOU ROAD, MUCHA, TAIPEI, TAIWAN SN 1013-2511 J9 ISSUES STUD JI Issues Stud. PD MAR PY 2005 VL 41 IS 1 BP 244 EP 250 PG 7 WC Area Studies; International Relations; Political Science SC Area Studies; International Relations; Government & Law GA 910ZF UT WOS:000227970000012 ER PT J AU Kindsvatter, PS AF Kindsvatter, Peter S. TI The "casualty issue" in American military practice: The impact of World War I. SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 USA, Ordnance Ctr & Sch, Aberdeen Proving Ground, MD USA. RP Kindsvatter, PS (reprint author), USA, Ordnance Ctr & Sch, Aberdeen Proving Ground, MD USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD MAR PY 2005 VL 91 IS 4 BP 1507 EP 1508 PG 2 WC History SC History GA 082JB UT WOS:000240381500113 ER PT J AU Dworzanski, JP Tripathi, A Snyder, AP Maswdeh, WM Wick, CH AF Dworzanski, JP Tripathi, A Snyder, AP Maswdeh, WM Wick, CH TI Novel biomarkers for Gram-type differentiation of bacteria by pyrolysis-gas chromatography-mass spectrometry SO JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS LA English DT Article DE pyrolys : s-gas chromatography-mass spectrometry; gram-positive bacteria; gram-negative bacteria; peptidoglycan; lipopolysaccharide ID ION MOBILITY SPECTROMETRY; CURIE-POINT PYROLYSIS; AMINO-ACIDS; LIQUID CHROMATOGRAPHY; CELL-WALL; LIPOPOLYSACCHARIDE; AEROSOLS; PEPTIDOGLYCAN; SYSTEM; GROWTH AB The pyrolysis-gas chromatography (Py-GC) module of a fielded, briefcase Py-GC-ion mobility spectrometry (Py-GC-IMS) biodetector is shown to generate a set of specific products that reflect the biochemical composition of bacterial cell envelopes. A prominent pyrolysis biomarker derived from the cell walls of Gram-positive bacteria has been identified as pyridine-2-carboxamide (2-picolinamide). Experiments performed using model polymers strongly suggest its origin from the thermal rearrangements of the meso-diaminopimelic acid and/or L-lysine peptide residue cross-linker species in peptidoglycan. Biomarkers produced by pyrolysis from Gram-negative organisms were found to originate from de lipid A portion of the lipopolysaccharide (LPS) cell surface. These biomarkers include pyrolysis products of the 3-hydroxymyristate fatty acid residues such as 1-tridecene, dodecanal and methylundecylketone. A nitrile derivative from amide bound fatty acids and free fatty acids originally present as ester bound moieties in lipid A are also observed upon bacterial pyrolysis. The presence of these biomarkers directly reflect similar information content provided by a classical Gram staining procedure and make them suitable for direct Gram-type differentiation of micro-organisms. Crown Copyright © 2004 Published by Elsevier B.V. All rights reserved. C1 Geocenters Inc, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Dworzanski, JP (reprint author), Geocenters Inc, Gunpowder Branch, POB 68, Aberdeen Proving Ground, MD 21010 USA. EM jdworzanski@geo-centers.com NR 34 TC 18 Z9 19 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2370 J9 J ANAL APPL PYROL JI J. Anal. Appl. Pyrolysis PD MAR PY 2005 VL 73 IS 1 BP 29 EP 38 DI 10.1016/j.jaap.2004.09.003 PG 10 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA 925KT UT WOS:000229052700003 ER PT J AU Wang, L Hashimoto, Y Tsao, CY Valdes, JJ Bentley, WE AF Wang, L Hashimoto, Y Tsao, CY Valdes, JJ Bentley, WE TI Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli SO JOURNAL OF BACTERIOLOGY LA English DT Article ID QUORUM-SENSING SIGNAL; GRAM-POSITIVE BACTERIA; TO-CELL COMMUNICATION; SALMONELLA-TYPHIMURIUM; VIBRIO-HARVEYI; BINDING-SITES; EXPRESSION; GENES; LUXS; AL-2 AB Bacterial autoinducer 2 (AI-2) is proposed to be an interspecies mediator of cell-cell communication that enables cells to operate at the multicellullar level. Many environmental stimuli have been shown to affect the extracellular AI-2 levels, carbon sources being among the most important. In this report, we show that both AI-2 synthesis and uptake in Escherichia coli are subject to catabolite repression through the cyclic AMP (cAMP)-CRP complex, which directly stimulates transcription of the Isr (for "luxS regulated") operon and indirectly represses luxS expression. Specifically, cAMP-CRP is shown to bind to a CRP binding site located in the upstream region of the Isr promoter and works with the LsrR repressor to regulate AI-2 uptake. The functions of the Isr operon and its regulators, LsrR and LsrK, previously reported in Salmonella enterica serovar Typhimurium, are confirmed here for E. coli. The elucidation of cAMP-CRP involvement in E. coli autoinduction impacts many areas, including the growth of E. coli in fermentation processes. C1 Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA. Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA. Univ Maryland, Dept Chem Engn, College Pk, MD 20742 USA. US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Bentley, WE (reprint author), Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA. EM bentley@eng.umd.edu NR 61 TC 98 Z9 110 U1 3 U2 19 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD MAR PY 2005 VL 187 IS 6 BP 2066 EP 2076 DI 10.1128/JB.187.6.2066-2076.2005 PG 11 WC Microbiology SC Microbiology GA 905NJ UT WOS:000227575100023 PM 15743955 ER PT J AU Mozingo, DW Barillo, DJ Holcomb, JB AF Mozingo, DW Barillo, DJ Holcomb, JB TI The Pope Air Force Base aircraft crash and burn disaster SO JOURNAL OF BURN CARE & REHABILITATION LA English DT Article AB This report describes the initial hospital and burn center management of a mass casualty incident resulting from an aircraft crash and fire. One hundred thirty soldiers were injured, including 10 immediate fatalities. Womack Army Medical Center at Fort Bragg, North Carolina, managed the casualties and began receiving patients 15 minutes after the crash. As a result of repetitive training that included at least two mass casualty drills each year, the triage area and emergency department were cleared of all patients within 2 hours. Fifty patients were transferred to burn centers, including 43 patients to the US Army Institute of Surgical Research. This constitutes the largest single mass casualty incident experienced in the 57-year history of the Institute. All patients of the US Army Institute of Surgical Research survived to hospital discharge, and 34 returned to duty 3 months after the crash. The scenario of an on-ground aircraft explosion and fire approximates what might be seen as a result of an aircraft hijacking, bombing, or intentional crash. Lessons learned from this incident have utility in the planning of future response to such disasters. C1 Univ Florida, Dept Surg, Div Trauma Burn & Emergency Surg, Gainesville, FL 32610 USA. USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Mozingo, DW (reprint author), Univ Florida, Dept Surg, Div Trauma Burn & Emergency Surg, POB 100286, Gainesville, FL 32610 USA. NR 13 TC 7 Z9 7 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0273-8481 J9 J BURN CARE REHABIL JI J. Burn Care Rehabil. PD MAR-APR PY 2005 VL 26 IS 2 BP 132 EP 140 DI 10.1097/01.BCR.0000155536.98314.D8 PG 9 WC Emergency Medicine; Rehabilitation; Surgery SC Emergency Medicine; Rehabilitation; Surgery GA 905ND UT WOS:000227574500007 PM 15756114 ER PT J AU Cancio, LC Horvath, EE Barillo, DJ Kopchinski, BJ Charter, KR Montalvo, AE Buescher, TM Brengman, ML Brandt, MM Holcomb, JB AF Cancio, LC Horvath, EE Barillo, DJ Kopchinski, BJ Charter, KR Montalvo, AE Buescher, TM Brengman, ML Brandt, MM Holcomb, JB TI Burn support for operation Iraqi freedom and related operations, 2003 to 2004 SO JOURNAL OF BURN CARE & REHABILITATION LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the American-Burn-Association CY MAR 24-26, 2004 CL Vancouver, CANADA SP Amer Burn Assoc AB Thermal injury historically constitutes approximately 5% to 20% of conventional warfare casualties. This article reviews medical planning for burn care during war in Iraq and experience with burns during the war at the US Army Burn Center; aboard the USNS Comfort hospital ship; and at Combat Support Hospitals in Iraq and in Afghanistan. Two burn surgeons were deployed to the military hospital in Landstuhl, Germany, and to the Gulf Region to assist with triage and patient care. During March 2003 to May 2004, 109 burn casualties from the war have been hospitalized at the US Army Burn Center in San Antonio, Texas, and US Army Burn Flight Teams have moved 51 critically ill burn casualties to the Burn Center. Ten Iraqi burn patients underwent surgery and were hospitalized for up to 1 month aboard the Comfort, including six with massive wounds. Eighty-six burn casualties were hospitalized at the 28th Combat Support Hospital for up to 53 days. This experience highlights the importance of anticipating the burn care needs of both combatants and the local civilian population during war. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Natl Naval Med Res Inst, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Michigan Hlth Syst, Trauma Burn Ctr, Ann Arbor, MI USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. OI Brandt, Mary-Margaret/0000-0002-8667-350X NR 21 TC 43 Z9 45 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0273-8481 J9 J BURN CARE REHABIL JI J. Burn Care Rehabil. PD MAR-APR PY 2005 VL 26 IS 2 BP 151 EP 161 DI 10.1097/01.BCR.0000155540.31879.FB PG 11 WC Emergency Medicine; Rehabilitation; Surgery SC Emergency Medicine; Rehabilitation; Surgery GA 905ND UT WOS:000227574500010 PM 15756117 ER PT J AU Barillo, DJ Cancio, LC Hutton, BG Mittelsteadt, PJ Gueller, GE Holcomb, JB AF Barillo, DJ Cancio, LC Hutton, BG Mittelsteadt, PJ Gueller, GE Holcomb, JB TI Combat burn life support: A military burn-education program SO JOURNAL OF BURN CARE & REHABILITATION LA English DT Article AB The Advanced Burn Life Support Course has been used to train military physicians and nurses for more than 16 years. Although it useful for teaching the fundamentals of burn care, the course is designed for a civilian audience, covers only the first 24 hours of burn care, and presumes the availability of a burn center for patient transfer. In preparation for hostilities in Iraq, we developed several add-on modules to the standard Advanced Burn Life Support course to meet specific needs of military audiences. These modules cover the treatment of white phosphorus burns; the treatment of mustard gas exposure; the long-range aeromedical transfer of burn patients; the management of burn patients beyond the first 24 hours; and the delivery of burn care in austere environments. These add-on modules are termed Combat Burn Life Support. Between January 22, 2003, and May 12, 2003, Advanced Burn Life Support and/or Combat Burn Life Support courses were provided to a total of 1035 military health care providers in the United States, Germany, and the Middle East. Student feedback was largely positive and is being used for further course refinement. The Combat Burn Life Support Course is designed to augment, rather than replace, the Advanced Burn Life Support Course. Although intended for a military audience, the course material is equally applicable to civilian terrorist or mass casualty situations. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Barillo, DJ (reprint author), 719 Angus Ct, Mt Pleasant, SC 29464 USA. NR 3 TC 6 Z9 8 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0273-8481 J9 J BURN CARE REHABIL JI J. Burn Care Rehabil. PD MAR-APR PY 2005 VL 26 IS 2 BP 162 EP 165 DI 10.1097/01.BCR.0000155541.31016.92 PG 4 WC Emergency Medicine; Rehabilitation; Surgery SC Emergency Medicine; Rehabilitation; Surgery GA 905ND UT WOS:000227574500011 PM 15756118 ER PT J AU Greenfield, E Winfree, J AF Greenfield, E Winfree, J TI Nursing's role in the planning, preparation, and response to burn disaster or mass casualty events SO JOURNAL OF BURN CARE & REHABILITATION LA English DT Editorial Material C1 Army Nurse Corps, San Antonio, TX USA. USA, Inst Surg Res, Army Nurse Corps, Ft Sam Houston, TX 78234 USA. RP Greenfield, E (reprint author), 2172 US Hwy 181 S, Floresville, TX 78114 USA. NR 5 TC 2 Z9 2 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0273-8481 J9 J BURN CARE REHABIL JI J. Burn Care Rehabil. PD MAR-APR PY 2005 VL 26 IS 2 BP 166 EP 169 DI 10.1097/01.BCR.0000155542.40176.30 PG 4 WC Emergency Medicine; Rehabilitation; Surgery SC Emergency Medicine; Rehabilitation; Surgery GA 905ND UT WOS:000227574500012 PM 15756119 ER PT J AU Barillo, DJ Jordan, MH Jocz, RJ Nye, D Cancio, LC Holcomb, JB AF Barillo, DJ Jordan, MH Jocz, RJ Nye, D Cancio, LC Holcomb, JB TI Tracking the daily availability of burn beds for national emergencies SO JOURNAL OF BURN CARE & REHABILITATION LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the American-Burn-Association CY MAR 24-26, 2004 CL Vancouver, CANADA SP Amer Burn Assoc AB Medical planning for Operation Iraqi Freedom included predictive models of expected number of burn casualties. In all but the best-case scenario, casualty estimates exceeded the capacity of the only Department of Defense burn center. Examination of existing federal-civilian disaster plans for military hospital augmentation revealed that bed availability data were neither timely nor accurate. Recognizing the need for accurate knowledge of burn bed availability, the Department of Defense requested assistance from the American Burn Association (ABA). Directors of burn centers in the United States were queried for interest in participation in a mass casualty plan to provide overflow burn bed capacity. A list of 70 participating burn centers was devised based upon proximity to planned military embarkation points. A computer tracking program was developed. Daily automated e-mail messages requesting bed status were sent to burn center directors at 6 Am Central time with responses requested before I I Am. The collated list of national overflow burn bed capacity was e-mailed each day to the ABA Central Office and to federal and military agencies involved with burn patient triage and transportation. Once automated, this task required only 1-2 hours a day. Available burn-bed lists were generated daily between March 17 and May 2, 2003 and then every other day until May 9, 2003. A total of 2151 responses were received (mean, 43 burn centers per day). A system to track daily nationwide burn bed availability was successfully implemented. Although intended for military conflict, this system is equally applicable to civilian mass casualty situations. We advocate adoption of this or a similar bed tracking system by the ABA for use during burn mass casualty incidents. C1 USA, Inst Surg Res, USA Burn Ctr, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Washington Hosp Ctr, Washington, DC 20010 USA. RP Barillo, DJ (reprint author), 719 Angus Ct, Mt Pleasant, SC 29464 USA. NR 6 TC 22 Z9 22 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0273-8481 J9 J BURN CARE REHABIL JI J. Burn Care Rehabil. PD MAR-APR PY 2005 VL 26 IS 2 BP 174 EP 182 DI 10.1097/01.BCR.0000155545.24253.45 PG 9 WC Emergency Medicine; Rehabilitation; Surgery SC Emergency Medicine; Rehabilitation; Surgery GA 905ND UT WOS:000227574500014 PM 15756121 ER PT J AU Andrews, AH Lake, JM Shorr, AE AF Andrews, AH Lake, JM Shorr, AE TI Ineffectiveness of routine abdominal radiography in patients with gastrointestinal hemorrhage admitted to an intensive care unit SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE gastrointestinal bleeding; plain abdominal radiography ID ACUTE ABDOMEN; PAIN; EMERGENCY; EFFICACY AB Goals: To determine the utility of plain abdominal radiography in the initial evaluation of acute gastrointestinal (GI) hemorrhage in a medical intensive care unit. Background: Plain abdominal radiographs are frequently used in the routine evaluation of patients with GI bleeding. The utility of these studies in the intensive care unit setting is unclear. Study: The study was a retrospective chart review of 71 adult subjects admitted to a medical intensive care unit with the diagnosis of GI bleeding. Subjects were excluded if they presented with peritoneal signs, received an abdominal CT scan in the 24 hours prior to admission, or were chronically treated with immunosuppressive medication. Subjects were divided into two cohorts based on whether or not they underwent plain abdominal radiography during the first hospital day. The primary study endpoints were hospital mortality, intensive care unit length of stay, and whether or not radiographic findings altered clinical management. Results: Of the 71 patients admitted with a diagnosis of GI bleeding (mean age 65.8 +/- 14.5 years, 73.2% male), 56 (79%) had a plain abdominal radiograph performed. Subjects who had a plain film did not differ significantly from those who did not in age, gender, degree of anemia, degree of coagulopathy, or in severity of illness as measured by Acute Physiology and Chronic Health Evaluation (APACHE II) score. There was no statistically significant difference in hospital mortality or intensive care unit length of stay between patients who received plain films and those who did not. In no subject (0%; 95% confidence interval, 0%-5.4%) did abdominal radiography reveal an abnormality that altered clinical management. Conclusions: Based on our observations, plain films of the abdomen do not appear to alter clinical outcomes or management decisions for patients with GI bleeding and normal abdominal examinations who are admitted to the intensive care unit. C1 Walter Reed Army Med Ctr, Dept Gastroenterol, Washington, DC 20307 USA. RP Andrews, AH (reprint author), Walter Reed Army Med Ctr, Dept Gastroenterol, 6900 Georgia Ave,Bldg 2,7th Floor, Washington, DC 20307 USA. EM hiroshi@post.harvard.edu NR 16 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD MAR PY 2005 VL 39 IS 3 BP 228 EP 231 DI 10.1097/01.mcg.0000152781.14642.d7 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 901FF UT WOS:000227267700008 PM 15718865 ER PT J AU Rosati, JD AF Rosati, JD TI Concepts in sediment budgets SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE uncertainty; sensitivity testing; Long Island; New York; Ocean City Inlet; Maryland; regional scale; computer program; beaches AB The sediment budget is fundamental in coastal science and engineering. Budgets allow estimates to be made of the volume or volume rate of sediment entering and exiting a defined region of the coast and the surplus or deficit 01 remaining in that region. Sediment budgets have been regularly employed with variations in approaches to determine the sources and sinks through application of the primary conservation of mass equation. Historically, sediment budgets have been constructed and displayed on paper or maps. Challenges in constructing a sediment budget include determining the appropriate boundaries of the budget and interior cells; defining the possible range of sediment transport pathways, and the relative magnitude of each; representing the uncertainty associated with values and assumptions in the budget; and testing the sensitivity of the series of budgets to variations in the unknown and temporally-changing values. These challenges are usually addressed by representing a series of budget alternatives that are ultimately drawn on paper, maps, or graphs. Applications of the methodology include detailed local-scale sediment budgets, such as for an inlet or beach fill project, and large-scale sediment budgets for the region surrounding the study area. The local-scale budget has calculation cells representing features on the order of 10s to 100s of meters, and it must be shown separately from the regional sediment budget, with cells ranging from 100s of meters to kilometers. This paper reviews commonly applied sediment budget concepts and introduces new considerations intended to make the sediment budget process more reliable, streamlined, and understandable. The need for both local and regional sediment budgets is discussed, and the utility of combining, or collapsing, cells is shown to be beneficial for local budgets within a regional system. Collapsing all cells within the budget creates a "macrobudget," which can be applied to check for overall balance of values. An automated means of changing the magnitude of terms, while maintaining the same dependency on other values within the sediment budget, is presented. Finally, the need for and method of tracking uncertainty within the sediment budget, and a means for conducting sensitivity analyses, are discussed. These new concepts are demonstrated within the Sediment Budget Analysis System with an application for Long Island, New York, and Ocean City Inlet, Maryland. C1 USA, Corps Engineers, Engineer Res Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Rosati, JD (reprint author), USA, Corps Engineers, Engineer Res Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. NR 43 TC 40 Z9 40 U1 1 U2 21 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD MAR PY 2005 VL 21 IS 2 BP 307 EP 322 DI 10.2112/02-475A.1 PG 16 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 922MU UT WOS:000228842800009 ER PT J AU Jiang, RZ Rong, C Chu, D AF Jiang, RZ Rong, C Chu, D TI Combinatorial approach toward high-throughput analysis of direct methanol fuel cells SO JOURNAL OF COMBINATORIAL CHEMISTRY LA English DT Article ID CHEMISTRY METHODS; ELECTROCHEMICAL ANALYSIS; COATINGS LIBRARIES; MEMBRANE; DISCOVERY; OXIDATION; ELECTROCATALYSTS; PERFORMANCE; DESIGN; ARRAYS AB A 40-member array of direct methanol fuel cells (with stationary fuel and convective air supplies) was generated by electrically connecting the fuel cells in series. High-throughput analysis of these fuel cells was realized by fast screening of voltages between the two terminals of a fuel cell at constant current discharge. A large number of voltage-current curves (200) were obtained by screening the voltages through multiple small-current steps. Gaussian distribution was used to statistically analyze the large number of experimental data. The standard deviation (a) of voltages of these fuel cells increased linearly with discharge current. The voltage-current curves at various fuel concentrations were simulated with an empirical equation of voltage versus current and a linear equation of a versus current. The simulated voltage-current curves fitted the experimental data well. With increasing methanol concentration from 0.5 to 4.0 M, the Tafel slope of the voltage-current curves (at sigma = 0.0), changed from 28 to 91 mV(.)dec(-1), the cell resistance from 2.91 to 0.18 Omega, and the power output from 3 to 18 mW(.)cm(-2). C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Jiang, RZ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM RJiang@Arl.Army.mil NR 37 TC 15 Z9 15 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-4766 J9 J COMB CHEM JI J. Comb. Chem. PD MAR-APR PY 2005 VL 7 IS 2 BP 272 EP 278 DI 10.1021/cc0498581 PG 7 WC Chemistry, Applied; Chemistry, Medicinal; Chemistry, Multidisciplinary SC Chemistry; Pharmacology & Pharmacy GA 907HV UT WOS:000227708100016 PM 15762756 ER PT J AU Evans, G Staudenmeier, JJ AF Evans, G Staudenmeier, JJ TI Family member presence during electroconvulsive therapy: Patient rights versus medical culture SO JOURNAL OF ECT LA English DT Letter ID WATCH RESUSCITATION; INVASIVE PROCEDURES; RELATIVES; EXPERIENCE C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Evans, G (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 19 TC 2 Z9 2 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1095-0680 J9 J ECT JI J. ECT PD MAR PY 2005 VL 21 IS 1 BP 48 EP 50 DI 10.1097/01.yct.0000155848.30290.3b PG 3 WC Behavioral Sciences; Psychiatry SC Behavioral Sciences; Psychiatry GA 912WK UT WOS:000228110400016 PM 15791179 ER PT J AU Flory, IL Kauffmann, P Holt, M Lewis, VW AF Flory, Isaac L. Kauffmann, Paul Holt, Michael Lewis, Vernon W., Jr. TI Writing Performance: A Comparison Between Engineering and Engineering Technology Students SO JOURNAL OF ENGINEERING TECHNOLOGY LA English DT Article AB Writing performance is a critical workplace skill for engineering and engineering technology students. To examine how well students develop this critical skill, this paper statistically analyzes the performance of these two groups of students on an exit writing examination. It compares the pass rates within engineering and engineering technology majors including civil, electrical, mechanical, and computer (engineering only). Secondly, it evaluates factors that may influence pass rates such as skills in English as a second language (ESL) and transfer status. The study shows that while there is an empirical difference in the performance between engineering and engineering technology students on an undergraduate Exit Examination of Writing Proficiency, this difference is not statistically significant. Concerning factors that may influence pass rates. ESL status had a highly negative influence and transfer students status had a positive influence. The paper identifies areas for additional study and proposes approaches to address these research questions. C1 [Flory, Isaac L.; Kauffmann, Paul] Old Dominion Univ, Dept Engn Technol, Norfolk, VA 23529 USA. [Holt, Michael] USA, Washington, DC USA. RP Flory, IL (reprint author), Old Dominion Univ, Dept Engn Technol, Norfolk, VA 23529 USA. NR 8 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N ST, N W, STE 600, WASHINGTON, DC 20036 USA SN 0747-9964 J9 J ENG TECHNOL JI J. Eng. Technol. PD SPR PY 2005 VL 22 IS 1 BP 38 EP 43 PG 6 WC Engineering, Multidisciplinary SC Engineering GA V83IU UT WOS:000205633600005 ER PT J AU Sheehan, JR Doll, WE Mandell, WA AF Sheehan, JR Doll, WE Mandell, WA TI An evaluation of methods and available software for seismic refraction tomography analysis SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Article AB Seismic refraction tomography is an alternative to conventional seismic refraction analysis methods. While the limitations and potential pitfalls of conventional refraction methods are well-known the same is not true for refraction tomography. As refraction tomography becomes more widely used, the need to know and understand its capabilities as well as its limitations becomes more critical. In this study we created eight representative models for use in evaluating three commercially available codes as well as refraction tomography in general. These models range from simple two-layer or dipping-layer problems to more complicated models designed to represent features of karst terrains. We demonstrate quantitatively and qualitatively that all three codes perform at a similar level, although each has strengths and weaknesses. Refraction tomography performs well in many situations where conventional methods fail, e.g., where lateral or vertical gradients compose a significant component of the velocity structure. C1 Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. USA, Ctr Environm, Aberdeen Proving Ground, MD 21010 USA. RP Sheehan, JR (reprint author), Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. NR 12 TC 45 Z9 46 U1 0 U2 6 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOCIETY PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD MAR PY 2005 VL 10 IS 1 BP 21 EP 34 DI 10.2113/JEEG10.1.21 PG 14 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA 913XE UT WOS:000228188100002 ER PT J AU Perovich, DK AF Perovich, DK TI On the aggregate-scale partitioning of solar radiation in Arctic sea ice during the Surface Heat Budget of the Arctic Ocean (SHEBA) field experiment SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID OPTICAL-PROPERTIES; ENERGY BUDGET; SNOW COVER; VARIABILITY; ALBEDO; MODEL; FLUX; EVOLUTION; SUMMER; EXTENT AB [1] The partitioning of the incident solar irradiance among reflection to the atmosphere, absorption in the snow and ice, and transmission to the ocean is a critical component of the summer melt cycle of Arctic sea ice. Observations from a year-long field experiment ( Surface Heat Budget of the Arctic Ocean (SHEBA)) showed that of the solar radiation incident between 1 April and 5 October 1998, 68% was reflected to the atmosphere, 24% was absorbed in the snow and ice, and 8% was transmitted to the ocean. The amount of energy reflected to the atmosphere was greatest in May, when the surface albedo and the incident irradiance were large. The energy absorbed in the snow and ice increased slowly in April and May in conjunction with the increase in incident solar irradiance, followed by a sharp increase in June associated with the onset of melt. In spring, virtually none of the solar energy incident on snow-covered sea ice is transmitted to the ocean compared to over 90% of that incident on leads. The energy transmitted to the ocean reached a maximum near the end of the melt season in mid-August when the albedo and ice thickness were at minima and lead and pond fractions were at maxima. While much of the solar energy transmitted to the ocean was through leads, substantial portions were also transmitted through bare ice ( 23%) and ponded ice (16%). During the melt season, the combined energy transmitted through bare ice and ponds was equivalent to that through leads. This marked a significant change in the interaction of solar energy with the sea ice cover, with substantial amounts of solar energy transmitted to the ocean through the thin summer ice cover of SHEBA compared to the thicker ice studied in 1975 ( Arctic Ice Dynamics Joint Experiment (AIDJEX)). C1 Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Perovich, DK (reprint author), Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM donald.k.perovich@erdc.usace.army.mil NR 47 TC 43 Z9 43 U1 0 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAR 1 PY 2005 VL 110 IS C3 AR C03002 DI 10.1029/2004JC002512 PG 12 WC Oceanography SC Oceanography GA 905ES UT WOS:000227551400002 ER PT J AU Alshawabkeh, AN Bricka, RM Gent, DB AF Alshawabkeh, AN Bricka, RM Gent, DB TI Pilot-scale electrokinetic cleanup of lead-contaminated soils SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article ID HEAVY-METALS; REMEDIATION; REMOVAL; KAOLINITE; ELECTROMIGRATION; ELECTROOSMOSIS; EXTRACTION AB The results of two pilot-scale experiments on enhanced electrokinetic extraction of lead from contaminated soil samples collected from a military Small Arms Training Facility are presented. The tests were conducted using two boxes with electrode spacing of 87 cm (Box 1) and 174 cut (Box 2). The soil was formed of a sandy layer on top of a clayey sand layer. The soil contained bullet fragments and the mean initial lead concentration in the minus 2.00 mm soil fraction was 3041 mg/kg and 1187 mg/kg in the sand and clayey sand layers, respectively. A Current density of 1.3A/m(2) was used in both tests and was doubled after 112 days of processing. organic acid was used to maintain the catholyte pH between 4 and 5. Box 1 and Box 2 were processed for 9 months and 11 months, respectively. The results showed that organic acid amendment at the cathode reduced the voltage and energy requirement by 70% and enhanced lead extraction. Lead transport showed a delay of about 14 days in the initial transport front development. For the conditions described in this study. the reactive rate of lead transport by ion migration and electroosmosis was 0.4 cm/day under 1 V/cm, which is less than 10% of the theoretical nonreactive value. There was a minimum limit for lead extraction from the soil by electrokinetics. Final lead concentrations in the treated sections were around 500 mg/kg in the sand and 400 mg/kg in the clayey sand. The results represent a reduced lead concentration by 85% in the sand and by 70% in the clayey sand. Complete breakthrough of lead did not occur due to accumulation near the cathode. even though catholyte pH was 4 to 5. A transverse upward transport and accumulation of lead at the soil surface was observed in both tests. Treatment duration of 9 months was adequate for Box 1, while 11 months of processing was not enough for Box 2 to bring the total lead concentration to below 500 mg/kg across the soil. Electrical energy cost for the process was between $14 and $18 per cubic meter per month. C1 Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA. Mississippi State Univ, Dave C Swalm Sch Chem Engn, Mississippi State, MS 39762 USA. USA, Ctr Res Dev & Engn, ERDC, EL EPE, Vicksburg, MS 39180 USA. RP Alshawabkeh, AN (reprint author), Northeastern Univ, Dept Civil & Environm Engn, 400 Snell Engn,360 Huntington Ave, Boston, MA 02115 USA. EM aalsha@coe.neu.edu; bricka@che.msstate.edu; gentd@wes.army.mil NR 31 TC 13 Z9 17 U1 3 U2 13 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD MAR PY 2005 VL 131 IS 3 BP 283 EP 291 DI 10.1061/(ASCE)1090-0241(2005)131:3(283) PG 9 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 899NH UT WOS:000227150700002 ER PT J AU Phuphuakrat, A Paris, RM Nittayaphan, S Louisirirotchanakul, S Auewarakul, P AF Phuphuakrat, A Paris, RM Nittayaphan, S Louisirirotchanakul, S Auewarakul, P TI Functional variation of HIV-1 Rev response element in a longitudinally studied cohort SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE RRE; disease progression; CD4(+) count ID VIRUS TYPE-1 INFECTION; VIRAL MESSENGER-RNA; LONG-TERM SURVIVORS; POLYMERASE CHAIN-REACTION; DISEASE PROGRESSION; EXPRESSION; SEQUENCES; ABSENCE; GENES; HETEROGENEITY AB We showed previously that HIV-1 Rev Response Element (RRE) contains a certain degree of structural variation, and in a set of limited samples, RRE from HIV-1 natural isolates were found to have functional variability. The significance of the RRE heterogeneity is addressed further by analyzing the functional variation of RREs in a longitudinal cohort. While the RRE activity at early time points was not a good predictor of disease outcome, the RRE activity at late time points was correlated with rates of CD4(+) count decline. These data suggest that RRE heterogeneity may be important in viral pathogenesis and disease progression. (C) 2005 Wiley-Liss, Inc. C1 Mahidol Univ, Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok 10700, Thailand. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Auewarakul, P (reprint author), Mahidol Univ, Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok 10700, Thailand. EM sipaw@mahidol.ac.th RI Auewarakul, Prasert /D-6015-2011; OI Auewarakul, Prasert/0000-0002-4745-4291 NR 32 TC 7 Z9 7 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD MAR PY 2005 VL 75 IS 3 BP 367 EP 373 DI 10.1002/jmv.20279 PG 7 WC Virology SC Virology GA 893EA UT WOS:000226700900001 PM 15648073 ER PT J AU Clark, CL Thompson, SH Brown, SA Fielding, C Baur, DA Helman, JI AF Clark, CL Thompson, SH Brown, SA Fielding, C Baur, DA Helman, JI TI Asymptomatic radiolucent lesion of the posterior mandible SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID CENTRAL MUCOEPIDERMOID CARCINOMA; SALIVARY-GLAND TUMORS; MAXILLA; JAWS C1 USA, Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. Univ Michigan, Hosp Dent, Sch Dent, Dept Oral & Maxillofacial Surg, Ann Arbor, MI 48109 USA. Univ Michigan, Ctr Med, Dept Surg, Sect Head Oral & Maxillofacial Surg, Ann Arbor, MI 48109 USA. RP Baur, DA (reprint author), USA, Eisenhower Army Med Ctr, 300 E Hosp Rd,Bldg 300,1st Floor, Ft Gordon, GA 30905 USA. EM dale.baur@se.amedd.army.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD MAR PY 2005 VL 63 IS 3 BP 377 EP 381 DI 10.1016/j.joms.2004.11.012 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 901EY UT WOS:000227267000016 PM 15742290 ER PT J AU Hsu, S Yamamoto, T Borke, J Walsh, DS Singh, B Rao, S Takaaki, K Nah-Do, N Lapp, C Lapp, D Foster, E Bollag, WB Lewis, J Wataha, J Osaki, T Schuster, G AF Hsu, S Yamamoto, T Borke, J Walsh, DS Singh, B Rao, S Takaaki, K Nah-Do, N Lapp, C Lapp, D Foster, E Bollag, WB Lewis, J Wataha, J Osaki, T Schuster, G TI Green tea polyphenol-induced epidermal keratinocyte differentiation is associated with coordinated expression of p57/KIP2 and caspase 14 SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID DEPENDENT KINASE INHIBITOR; TERMINAL DIFFERENTIATION; MESSENGER-RNA; P57(KIP2); CANCER; CELLS; INDUCTION; CARCINOMA; PROTEIN; SKIN AB Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, exerts chemopreventive effects by selectively inducing apoptosis in tumor cells. In contrast, EGCG accelerates terminal differentiation in normal human epidermal keratinocytes (NHEK) mediated partially by up-regulation of p57/KIP2, a cyclin-dependent kinase inhibitor that confers growth arrest and differentiation. However, it is unclear if EGCG modulates caspase 14, a unique regulator of epithelial cell terminal differentiation associated with cornification. Here, we examined the effect of EGCG on caspase 14 expression in NHEK and correlated the protein and mRNA expression of p57/KIP2 with those of caspase 14 in either normal keratinocytes or p57/KIP2-expressing tumor cells (OSC2, an oral squamous cell carcinoma cell line). Additionally, paraffin-embedded normal and untreated psoriatic (aberrant keratinization) skin sections from humans were assessed for caspase 14 by immunohistochemistry. In NHEK, EGCG induced the expression of caspase 14 mRNA and protein levels within a 24-h period. The expression of p57/KIP2 in OSC2 cells was adequate to induce caspase 14 in the absence of EGCG; this induction of caspase 14 was down-regulated by transforming growth factor-beta1. In human psoriatic skin samples, caspase 14 staining in the upper epidermis was reduced, especially in nuclear areas. These results suggest that, in addition to p57/KIP2, EGCG-induced terminal differentiation of epidermal keratinocytes involves up-regulation of caspase 14. Further understanding of how EGCG modulates cellular differentiation may be useful in developing green tea preparations for selected clinical applications. C1 Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, Augusta, GA 30912 USA. Med Coll Georgia, Sch Dent, Dept Biochem & Mol Biol, Augusta, GA 30912 USA. Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA. Kochi Med Sch, Dept Oral Surg, Kochi, Japan. Eisenhower Army Med Ctr, Dermatol Serv, Ft Gordon, GA USA. RP Hsu, S (reprint author), Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, AD1443, Augusta, GA 30912 USA. EM shsu@mail.mcg.edu FU NCI NIH HHS [R21 CA097258-01A1] NR 39 TC 28 Z9 29 U1 0 U2 3 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD MAR PY 2005 VL 312 IS 3 BP 884 EP 890 DI 10.1124/jpet.104.076075 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 897MR UT WOS:000227008800002 PM 15537824 ER PT J AU Blonder, J Hale, ML Chan, KC Yu, LR Lucas, DA Conrads, TP Zhou, M Popoff, MR Issaq, HJ Stiles, BG Veenstra, TD AF Blonder, J Hale, ML Chan, KC Yu, LR Lucas, DA Conrads, TP Zhou, M Popoff, MR Issaq, HJ Stiles, BG Veenstra, TD TI Quantitative profiling of the detergent-resistant membrane proteome of Iota-b toxin induced Vero cells SO JOURNAL OF PROTEOME RESEARCH LA English DT Article DE membrane proteins; quantitation; O-18/O-16 labeling; iota-b toxin ID CHROMATOGRAPHY-TANDEM MASS; LIPID RAFTS; BIOLOGICAL-ACTIVITY; PROTEINS; SPECTROMETRY; BINDING; RECEPTOR; CALNEXIN; O-18; IDENTIFICATION AB Enzyme-mediated O-18/O-16 differential labeling of proteome samples often suffers from incomplete exchange of the carboxy-terminus oxygen atoms, resulting in ambiguity in the measurable abundance differences. In this study, an O-18/O-16 labeling strategy was optimized for and applied to the solution-based cornparative analysis of the detergent-resistant membrane proteome (DRMP) of untreated and lota-b (lb)-induced Vero cells. Solubilization and tryptic digestion of the DRMP was conducted in a buffer containing 60% methanol. Unfortunately, the activity of trypsin is attenuated at this methanol concentration hampering the ability to obtain complete oxygen atom turnover. Therefore, the incorporation of the 110 atoms was decoupled from the protein digestion step by carrying out the trypsin-mediated heavy atom incorporation in a buffer containing 20% methanol; a concentration at which trypsin activity is enhanced compared to purely aqueous conditions. After isotopic labeling, the samples were combined, fractionated by strong cation exchange and analyzed by microcapillary reversed-phase liquid chromatography coupled on-line with electrospray ionization tandem mass spectrometry. In total, over 1400 unique peptides, corresponding to almost 600 proteins, were identified and quantitated, including all known caveolar and lipid raft marker proteins. The quantitative profiling of lb-induced DRMP from Vero cells revealed several proteins with altered expression levels suggesting their possible role in lb binding/uptake. C1 NCI, Lab Proteom & Analyt Technol, SAIC Frederick, Frederick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Toxicol, Dept Immunol & Mol Biol, Frederick, MD 21702 USA. Inst Pasteur, Anaerob Bacteria & Toxins Unit, F-75724 Paris, France. RP Veenstra, TD (reprint author), NCI, Lab Proteom & Analyt Technol, SAIC Frederick, PO Box B, Frederick, MD 21702 USA. EM veenstra@ncifcrf.gov FU NCI NIH HHS [N01-CO-12400] NR 48 TC 49 Z9 53 U1 1 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1535-3893 J9 J PROTEOME RES JI J. Proteome Res. PD MAR-APR PY 2005 VL 4 IS 2 BP 523 EP 531 DI 10.1021/pr049790s PG 9 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 916YE UT WOS:000228421900037 PM 15822930 ER PT J AU Ding, MS AF Ding, MS TI Excess Gibbs energy of mixing for organic carbonates from fitting of their binary phase diagrams with nonideal solution models SO JOURNAL OF SOLUTION CHEMISTRY LA English DT Article DE excess Gibbs energy; organic carbonate; phase diagram; solid-liquid equilibria; nonideal solution model; activity coefficient ID PLUS DIETHYL CARBONATE; LITHIUM BATTERIES; THERMODYNAMIC ANALYSIS; PROPYLENE CARBONATE; PC-DEC; EQUILIBRIA; CONDUCTIVITY; VISCOSITY; SYSTEM; LIPF6 AB The excess Gibbs energies of mixing in the liquid state were evaluated for all the ten binary combinations of these five organic carbonates: ethylene carbonate (EC), propylene carbonate, dimethyl carbonate (DMC), ethyl methyl carbonate, and diethyl carbonate by fitting their measured binary phase diagrams with thermodynamic nonideal solution models based on the regular solution model. Using the results of these model fits, activity coefficients of the components in the solvent mixtures were calculated for the binary series containing EC and DMC as the common component, and the composition-averaged excess Gibbs energies of mixing were calculated by integrating the energy in the whole composition range for all the binaries. The results showed the excess Gibbs energy of mixing, and therefore the intermolecular forces, to be responsible for the changes in the phase diagrams, in the activity coefficients, and in the composition-averaged excess energy for the different binary solution combinations. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Ding, MS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM mding@arl.army.mil NR 20 TC 1 Z9 1 U1 1 U2 9 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0095-9782 J9 J SOLUTION CHEM JI J. Solut. Chem. PD MAR PY 2005 VL 34 IS 3 BP 343 EP 359 DI 10.1007/s10953-005-3054-z PG 17 WC Chemistry, Physical SC Chemistry GA 931RX UT WOS:000229504000006 ER PT J AU Silton, SI AF Silton, SI TI Navier-Stokes computation's for a spinning projectile from subsonic to supersonic speeds SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article AB A computational study has been undertaken to predict the static-aerodynamic, Magnus-moment, and roll-damping coefficients of a standard spinning projectile using a single, modern, unstructured Navier-Stokes flow solver. Numerical results without engraving and semi-empirical results have been obtained for a wide range of Mach numbers to include subsonic, transonic, and supersonic flight regimes. Effects of 0-, 2-, and 5-deg angles of attack have been investigated. Flowfield characteristics of each flight regime are briefly explored. A comparison of coefficients calculated from the computational fluid dynamics results are made to both experimental range data as well as semi-empirical aeroprediction code results with some success. Good predictive capabilities are found for the static aerodynamic coefficients throughout all of the flight regimes. Discrepancies arise between the computational results and the experimental results for the Magnus moment and roll-damping coefficients due in part to the lack of engraving on the computational model. C1 USA, Res Lab, Weapons & Mat Res Directorate, Ballist & Weapons Concepts Div,Aerodynam Branch, Aberdeen Proving Ground, MD 21005 USA. RP Silton, SI (reprint author), USA, Res Lab, Weapons & Mat Res Directorate, Ballist & Weapons Concepts Div,Aerodynam Branch, Aberdeen Proving Ground, MD 21005 USA. EM ssilton@arl.army.mil NR 19 TC 13 Z9 14 U1 0 U2 4 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAR-APR PY 2005 VL 42 IS 2 BP 223 EP 231 DI 10.2514/1.4175 PG 9 WC Engineering, Aerospace SC Engineering GA 916VL UT WOS:000228414400005 ER PT J AU Seehusen, DA Baldwin, LM Runkle, GP Clark, G AF Seehusen, DA Baldwin, LM Runkle, GP Clark, G TI Are family physicians appropriately screening for postpartum depression? SO JOURNAL OF THE AMERICAN BOARD OF FAMILY PRACTICE LA English DT Article; Proceedings Paper CT Annual Meeting of the North-American-Primary-Care-Research-Group CY OCT 10-13, 2004 CL Orlando, FL SP N Amer Primary Care Res Grp ID POSTNATAL DEPRESSION; PRIMARY-CARE; CANCER; RECOGNITION; CHILDREN; MOTHERS; HEALTH; IMPACT AB Purpose: Despite the availability of screening tools for postpartum depression (PPD), there is a general consensus that the condition is underdiagnosed. This study was conducted to determine how frequently family physicians screen for PPD, what methods they use to screen, and what influences their screening frequency. Methods: A survey of members of the Washington Academy of Family Physicians was conducted. Three hundred sixty-two (60.9%) mailed surveys were returned. The 298 physicians who saw postpartum women and children younger than 1 year of age were included in the study. Results: Of the study population, 70.2% always or often screened for PPD at postpartum gynecologic examinations, and 46% always or often screened mothers at well-child visits. Of those who screened, 30.6% reported using a validated screening tool. Of those, only 18% used a tool specifically designed to screen for PPD. Logistic regression modeling showed that female sex [odds ratio (OR) = 2.2], training in PPD during residency (OR = 8.1), training in PPD through medical literature (OR = 2.1), and agreement that postpartum depression is common enough to warrant screening (OR = 1.9) were all significantly associated with more frequent screening at postpartum gynecologic visits. Agreement that screening takes too much effort was associated with less frequent screening (OR = 0.8). Conclusions: Although family physicians believe that PPD is serious, identifiable, and treatable; screening is not universal and use of screening tools designed for PPD is uncommon. Training in postpartum depression and female sex are the variables most strongly associated with frequent screening. C1 USA, Dept Family & Community Med, Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. Univ Washington, Dept Family Med, Seattle, WA 98195 USA. Madigan Army Med Ctr, Dept Family Med, Tacoma, WA 98431 USA. RP Seehusen, DA (reprint author), USA, Dept Family & Community Med, Eisenhower Army Med Ctr, Bldg 300, Ft Gordon, GA 30905 USA. EM dseehusen@msn.com NR 39 TC 37 Z9 38 U1 0 U2 3 PU AMER BOARD FAMILY PRACTICE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 0893-8652 J9 J AM BOARD FAM PRACT JI J. Am. Board Fam. Pract. PD MAR-APR PY 2005 VL 18 IS 2 BP 104 EP 112 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 911MT UT WOS:000228007900004 PM 15798139 ER PT J AU Klun, JA Kramer, M Debboun, M AF Klun, JA Kramer, M Debboun, M TI A new in vitro bioassay system for discovery of novel human-use mosquito repellents SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes aegypti; Anopheles stephensi; N,N-diethyl-3-methylbenzamide; (1S, 2 ' S)-methylpiperi-dinyl-3-cyclohexen-1-carboxamide; 2-(2-hydroxyethyl)-1-piperidine carboxylic acid 1-methylpropyl ester; yellow fever mosquito; Deet; Bayrepel((R)); SS-220; mosquito biting ID AEDES-AEGYPTI; EFFICACY; DEET; ASSAYS; TESTS; BLOOD; MODEL AB A Klun A Debboun (KAD) test module, previously developed and used for quantitative measurement of the efficacy of mosquito repellents on human volunteers, was adapted for in vitro evaluation of repellents by coupling the module with a membrane-blood reservoir. Performance of Deet, Bayrepel (R), and SS-220 insect repellents in the new in vitro system was compared with their performance on humans against mosquitoes using our standard in vivo system. For each compound, in vitro dose-response assays were conducted with compounds applied to cloth positioned over blood reservoirs covered with Baudruche membrane against Aedes aegypti. The repellents were also tested in vitro against Anopheles stephensi and Ae. aegypti at a fixed dose of 24 nmol compound/cm(2) cloth over the Baudruche and Edicol collagen membranes. Concurrently, the repellents were tested at the fixed dose using the KAD module on human volunteers. The observed proportions of both mosquito species deterred from biting in the fixed doses in the in vitro assays were similar to those obtained using humans, being clearly able to distinguish controls from repellents, and differing only in the ranking of the effectiveness of some of the repellents. Dose-response, relationships of the in vitro and in vivo systems were also very similar, although not directly comparable because the data were not collected concurrently. This new in vitro assay system can be used in high throughput screening of compounds to identify new repellents having potential for use as topical mosquito repellents on humans. C1 USDA ARS, Biometr Consulting Serv, Beltsville, MD 20705 USA. USA, Ctr Hlth Promot & Prevent Med S, Ft McPherson, GA 30330 USA. RP Klun, JA (reprint author), USDA ARS, PSI, Chem Affecting Insect Behav Lab, Beltsville, MD 20705 USA. NR 18 TC 55 Z9 56 U1 2 U2 12 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2005 VL 21 IS 1 BP 64 EP 70 DI 10.2987/8756-971X(2005)21[64:ANIVBS]2.0.CO;2 PG 7 WC Entomology SC Entomology GA 906GB UT WOS:000227627500012 PM 15825764 ER PT J AU Bilyk, SR Ramesh, KT Wright, TW AF Bilyk, SR Ramesh, KT Wright, TW TI Finite deformations of metal cylinders subjected to electromagnetic fields and mechanical forces SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Article DE electromechanical processes; strengthening and mechanisms; thermomechanical; finite deformation; viscoplastic materials; numerical algorithms ID STRAIN-RATE; DISLOCATION MOBILITY; ELECTRIC-CURRENT; ALPHA-TITANIUM; TEMPERATURE; CRYSTALS; ALUMINUM; FRICTION; COPPER AB Strong electromagnetic (EM) fields coupled with mechanical loads may have a profound effect on deforming bodies. The continuum description of the plastic deformation of solids under electric fields and mechanical loads essentially involves the coupling of the field equations of continuum mechanics with Maxwell's equations. This analysis considers the effects of large EM fields on solid metal cylinders undergoing plastic deformations. Other researchers have used an electroplastic effect to explain previous EM and mechanically loaded experimental results. We examine whether it is 'necessary to invoke this controversial mechanism. First, we consider only EM loading and solve the transient EM distribution in a solid metal cylinder. This determines the EM time scales as compared to thermal diffusion time scales. Next, at the continuum level, we present the mechanical problem of quasi-static finite compressive deformations incorporating thermal expansion, strain hardening, strain rate sensitivity, thermal softening, and heat conduction. A viscoplastic model that is applicable over a wide range of strain rates (10(-4)-10(6) S-1) Characterizes the material response. Finally, we consider a metal cylinder subjected to uni-axial mechanical loading as well as high axial current pulses. The material is assumed, to be isotropic with. the plastic incompressibility constraint. The deformations are assumed to remain axisymmetric and no instabilities in the cylinder are considered. Coupled effects of Joule heating and the Lorentz force on the quasi-static deformations are examined. (C) 2004 Elsevier Ltd. All rights reserved. C1 USA, Res Lab,TD, Weapons & Mat Res Directorate,WM, AMSRD,AR, Aberdeen Proving Ground, MD 21005 USA. Johns Hopkins Univ, Dept Engn Mech, Baltimore, MD 21218 USA. RP Bilyk, SR (reprint author), USA, Res Lab,TD, Weapons & Mat Res Directorate,WM, AMSRD,AR, Aberdeen Proving Ground, MD 21005 USA. EM bilyk@arl.army.mil NR 43 TC 13 Z9 14 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-5096 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD MAR PY 2005 VL 53 IS 3 BP 525 EP 544 DI 10.1016/j.jmps.2004.10.002 PG 20 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA 897QD UT WOS:000227018800002 ER PT J AU Yang, K He, JA Kumar, J Samuelson, LA Oshikiri, T Katagi, H Kasai, H Okada, S Oikawa, H Nakanishi, H Tripathy, SK AF Yang, K He, JA Kumar, J Samuelson, LA Oshikiri, T Katagi, H Kasai, H Okada, S Oikawa, H Nakanishi, H Tripathy, SK TI Study of a poly-1,6-dicarbazolyl-2,4-hexadiyne nanocrystal film by the fifth-order electroabsorption spectroscopy SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID DOPED POLYMER-FILMS; NONLINEAR-OPTICAL-PROPERTIES; MACH-ZEHNDER INTERFEROMETER; QUADRATIC ELECTROABSORPTION; ELECTROOPTIC COEFFICIENT; POLYDIACETYLENE FILMS; MODULATION TECHNIQUE; PHASE-MODULATION; SINGLE-CRYSTALS; SUSCEPTIBILITIES AB Electroabsorption spectroscopy is used to investigate the fifth-order nonlinear optical property of a polydiacetylene poly-1,6-dicarbazolyl-2,4-hexadiyne [poly(DCHD)] nanocrystal film assembled by sequential ionic adsorption. The fifth-order susceptibility spectrum clearly identifies the vibrational states, i.e., the double bond and triple bond stretching, which are not resolved in the linear absorption spectrum. These vibrational energies are consistent with those obtained from poly(DCHD) bulk crystal through Raman and electroreflectance spectroscopy at low temperatures. The contributions from the vibrational states are also included in the expressions of hyperpolarizabilities for the electro-optical process. The fit of the experimental data shows excellent agreement between the model and the experiment. (C) 2005 Optical-Society of America. C1 Univ Massachusetts, Ctr Adv Mat, Dept Phys & Appl Phys, Lowell, MA 01854 USA. Univ Massachusetts, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. USA, Dev & Engn Command, Natick Soldier Ctr, Natick, MA 01760 USA. Tohoku Univ, Inst Chem React Sci, Sendai, Miyagi 98077, Japan. RP Yang, K (reprint author), Univ Massachusetts, Ctr Adv Mat, Dept Phys & Appl Phys, Lowell, MA 01854 USA. NR 38 TC 3 Z9 3 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD MAR PY 2005 VL 22 IS 3 BP 623 EP 632 DI 10.1364/JOSAB.22.000623 PG 10 WC Optics SC Optics GA 905AC UT WOS:000227538800014 ER PT J AU Rhodes, AB O'Donnell, SD Gillespie, DL Rasmussen, TE Johnson, CA Fox, CJ Burklow, TR Hagler, DJ AF Rhodes, AB O'Donnell, SD Gillespie, DL Rasmussen, TE Johnson, CA Fox, CJ Burklow, TR Hagler, DJ TI The endovascular management of recurrent aortic hypoplasia and coarctation in a 15-year-old male SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 18th Annual Meeting of the Eastern-Vascular-Society CY APR 29-MAY 01, 2004 CL Philadelphia, PA SP Eastern Vasc Soc ID TO-END ANASTOMOSIS; ARCH AB A 15-year-old male complained of easy fatigability, leg weakness, and pain on exertion with episodes of syncope while playing baseball. His past medical history was significant for aortic coarctation associated with a congenital bovine hypoplastic aortic arch. A recent arteriogram revealed innominate and left common carotid artery stenosis as well as recurrent coarctation. He had previously undergone three Dacron patch aortoplasties. At the age of 7, he underwent a fourth operation for recurrent coarctation and because of extensive sear tissue in the region of his prior procedures, a left subdavian artery-to-descending aortic bypass was performed. An endovascular repair to deal with the recent recurrence was performed because of prior surgical difficulties. Percutaneous balloon-expandable stents were placed in the aortic coarctation, innominate, and the left common carotid arteries. Postprocedure, ankle brachial indices were > 1 and the patient remains asymptomatic after 1 year. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Mayo Clin, Coll Med, Div Pediat Cardiol, Rochester, MN USA. RP O'Donnell, SD (reprint author), Walter Reed Army Med Ctr, Vasc Surg Clin Ward 64,6900 Georgia Ave NW, Washington, DC 20307 USA. EM scan.odonnell@NA.AMEDD.ARMY.MIL OI Gillespie, David/0000-0002-4378-9465 NR 11 TC 3 Z9 3 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD MAR PY 2005 VL 41 IS 3 BP 531 EP 534 DI 10.1016/j.jvs.2004.09.035 PG 4 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 913SA UT WOS:000228172100027 PM 15838490 ER PT J AU Aitichou, M Saleh, SS McElroy, AK Schmaljohn, C Ibrahima, MS AF Aitichou, M Saleh, SS McElroy, AK Schmaljohn, C Ibrahima, MS TI Identification of Dobrava, Hantaan, Seoul, and Puumala viruses by one-step real-time RT-PCR SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Dobrava; Hantaan; Hantavirus; Puumala; Seoul; real-time; TaqMan; RT-PCR ID HANTAVIRUS PULMONARY SYNDROME; RIFT-VALLEY FEVER; POLYMERASE CHAIN-REACTION; HEMORRHAGIC-FEVER; RENAL SYNDROME; NEPHROPATHIA-EPIDEMICA; GENETIC IDENTIFICATION; FAMILY BUNYAVIRIDAE; UNITED-STATES; ANDES-VIRUS AB We developed four assays for specifically identifying Dobrava (DOB), Hantaan (HTN), Puumala (PUU), and Seoul (SEO) viruses. The assays are based on the real-time one-step reverse transcriptase polymerase chain reaction (RT-PCR) with the small segment used as the target sequence. The detection limits of DOB, HTN, PUU, and SEO assays were 25, 25, 25, and 12.5 plaque-forming units, respectively. The assays were evaluated in blinded experiments, each with 100 sample's that contained Andes, Black Creek Canal, Crimean-Congo hemorrhagic fever, Rift Valley fever and Sin Nombre viruses in addition to DOB, HTN, PUU and SEO viruses. The sensitivity levels of the DOB, HTN, PUU, and SEO assays were 98%, 96%, 92% and 94%, respectively. The specificity of DOB, HTN and SEO assays was 100% and the specificity of the PUU assay was 98%. Because of the high levels of sensitivity, specificity, and reproducibility, we believe that these assays can be useful for diagnosing and differentiating these four Old-World hantaviruses. (C) 2004 Elsevier B.V. All rights reserved. C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. Clin Res Management, Ft Detrick, MD 21702 USA. RP Ibrahima, MS (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM sofi.ibrahim@det.amedd.army.mil NR 42 TC 35 Z9 36 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD MAR PY 2005 VL 124 IS 1-2 BP 21 EP 26 DI 10.1016/j.viromet.2004.10.004 PG 6 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 895SH UT WOS:000226883100003 PM 15664046 ER PT J AU Nestler, JM Goodwin, RA Loucks, DP AF Nestler, JM Goodwin, RA Loucks, DP TI Coupling of engineering and biological models for ecosystem analysis SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article ID SIMULATION; POPULATIONS; DYNAMICS; PATTERNS; SCALES AB Robust ecosystem analysis of water resource systems remains elusive. A principle reason is the difficulty in linking engineering models used to simulate physicochemical processes associated with project design or operation with biological models used to simulate biological population attributes. A retrospective shows that each modeling tradition can be generally assigned (with exceptions) into either an Eulerian or Lagrangian reference framework. Eulerian and Lagrangian reference frameworks can be coupled to create a new synthesis, the Coupled Eulerian-Lagrangian Hybrid Ecological Modeling Concept (CEL Hybrid Concept), capable of simulating different ecosystem processes that range widely in spatial and temporal scale. The foundation of the CEL Hybrid Concept is the coupler, a collection of algorithms based on conservation principles that transform and conserve data in a way that allows the two frameworks to share a common information base. The coupling algorithm allows the simulation to aggregate, disaggregate, and translate information, as required by each framework-, so that processes that differ substantially in scale can each be adequately simulated. The coupled system is illustrated by linking a fish swim path selection model with a hydrodynamic and water quality model. C1 USA Engineer, Environm Lab, CERD EP W, Ctr Res & Dev, Vicksburg, MS 39180 USA. Cornell Univ, Environm Lab, US Army Engineer Res & Dev Ctr, CENWP EC HD, Portland, OR 97208 USA. Cornell Univ, Ithaca, NY 14853 USA. RP Nestler, JM (reprint author), USA Engineer, Environm Lab, CERD EP W, Ctr Res & Dev, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM john.m.nestler@erdc.usace.army.mil; ragl2@cornell.edu; DPL3@cornell.edu NR 40 TC 6 Z9 6 U1 1 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD MAR-APR PY 2005 VL 131 IS 2 BP 101 EP 109 DI 10.1061/(ASCE)0733-9496(2005)131:2(101) PG 9 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 898VH UT WOS:000227103800004 ER PT J AU Stark, TD Choi, H Schroeder, PR AF Stark, TD Choi, H Schroeder, PR TI Settlement of dredged and contaminated material placement areas. I: Theory and use of Primary Consolidation, Secondary Compession, and Desiccation of Dredged Fill SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB A 1D nonlinear numerical model, Primary Consolidation, Secondary Compression, and Desiccation of Dredged Fill (PSDDF), is presented to predict the settlement of fine-grained dredged material and/or underlying compressible foundation materials that may be over-. under-. or normally consolidated. The three most important natural processes affecting the long-term settlement and thus service life of dredged material placement areas are primary consolidation, secondary compression, and desiccation. Nonlinear finite-strain consolidation theory is used to predict the settlement due to self-weight and surcharge-induced consolidation. The C-alpha/C-c concept is used to predict the settlement from secondary compression, and an empirical desiccation model is used to describe the settlement from removal of water from confined dredged material by surface drying. This paper describes the modifications and improvements of PSDDF that present new functions and enhanced numerical efficiency. A companion paper describes the input parameters of PSDDF. C1 Univ Illinois, Urbana, IL 61801 USA. Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Stark, TD (reprint author), Univ Illinois, 205 N Mathews Ave, Urbana, IL 61801 USA. EM tstark@uiuc.edu; hchoi@uakron.edu; Paul.R.Schroeder@erdc.usace.army.mil NR 12 TC 8 Z9 8 U1 2 U2 9 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAR-APR PY 2005 VL 131 IS 2 BP 43 EP 51 DI 10.1061/(ASCE)0733-950X(2005)131:2(43) PG 9 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 898SY UT WOS:000227097700001 ER PT J AU Stark, TD Choi, H Schroeder, PR AF Stark, TD Choi, H Schroeder, PR TI Settlement of dredged and contaminated material placement areas. II: Primary Consolidation, Secondary Compression, and Desiccation of Dredged Fill input parameters SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB This paper presents practical applications of PSDDF (Primary Consolidation, Secondary Compression, and Desiccation of Dredged Fill), which is described in a companion paper by the writers. In addition, consolidation and desiccation parameters for 27 dredged materials are presented from 20 U.S. Army Corps of Engineers placement areas to facilitate usage of PSDDF. The consolidation parameters of three cohesionless soils for sand capping and drainage and three compressible foundation materials are included to provide a PSDDF user with suitable parameters for these material types. To reduce the difficulty of obtaining the consolidation and desiccation parameters for dredged material, empirical correlations between the required parameters and soil index properties are presented. C1 Univ Illinois, Urbana, IL 61801 USA. Univ Akron, Akron, OH 44325 USA. USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Stark, TD (reprint author), Univ Illinois, 205 N Mathews Ave, Urbana, IL 61801 USA. EM tstark@uiuc.edu; hchoi@uakron.edu; Paul.R.Schroeder@erdc.usace.army.mil NR 13 TC 11 Z9 11 U1 0 U2 12 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAR-APR PY 2005 VL 131 IS 2 BP 52 EP 61 DI 10.1061/(ASCE)0733-950X(2005)131:2(52) PG 10 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 898SY UT WOS:000227097700002 ER PT J AU Gilcreast, DM Warren, JB Yoder, LH Clark, JJ Wilson, JA Mays, MZ AF Gilcreast, DM Warren, JB Yoder, LH Clark, JJ Wilson, JA Mays, MZ TI Research comparing three heel ulcer-prevention devices SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING LA English DT Article ID PRESSURE SORE RISK; BRADEN SCALE AB OBJECTIVE: To compare 3 pressure-reduction devices for effectiveness in prevention of heel ulcers in moderate-risk to high-risk patients. DESIGN: A prospective quasi-experimental 3-group design was used. SETTING AND SUBJECTS: A sample of 338 "moderate-risk to high-risk" adult inpatients, ages 18 to 97, at 2 medical centers in South Texas were studied. INSTRUMENTS: The Braden Scale for Pressure Ulcer Risk and investigator-developed history and skin assessment tools were used. METHODS: Subjects were randomly assigned to the High-Cushion Kodel Heel Protector (bunny boot), Egg Crate Heel Lift Positioner (egg crate), or EHOB Foot Waffle Air Cushion (foot waffle). Data are demographics, Braden scores, comorbidities, skin assessments, lengths of stay, and costs of devices. Analyses were Chi-square, analysis of variance, and regression. RESULTS: Of 240 subjects with complete data, 77 (32%) were assigned to the bunny boot group, 87 (36.3%) to the egg crate, and 76 (31.7%) to the foot waffle. Twelve ulcers developed in 240 subjects (5% incidence). Six subjects had only 1 foot. Eleven ulcers were Stage I (nonblanchable erythema), and 1 was Stage II (partial thickness). Overall incidence was 3.9% for the bunny boot, 4.6% for the egg crate, and 6.6% for the foot waffle (not significantly different among groups). The bunny boot with pillows was most cost effective ((F[3], N 240) = 1.342, p <= .001). CONCLUSIONS: In this study, the bunny boot was as effective as higher-tech devices. The results, however, were confounded by nurses adding pillows to the bunny boot group. C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX 78229 USA. Brooke Army Med Ctr, Wound & Ostomy Serv, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. Wilford Hall USAF Med Ctr, Wound Ostomy & Continence Serv, Lackland AFB, TX 78236 USA. Univ Arizona, Sch Med, Tucson, AZ 85721 USA. RP Gilcreast, DM (reprint author), 5647 Wood Climb St, San Antonio, TX 78233 USA. EM gilcreast@uthscsa.edu NR 25 TC 16 Z9 17 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1071-5754 J9 J WOUND OSTOMY CONT JI J. Wound Ostomy Cont. Nurs. PD MAR-APR PY 2005 VL 32 IS 2 BP 112 EP 120 PG 9 WC Nursing SC Nursing GA 020DJ UT WOS:000235888300008 PM 15867701 ER PT J AU Sliney, D AF Sliney, D TI Do laser pointers present an aviation hazard? SO LASER FOCUS WORLD LA English DT Editorial Material C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Sliney, D (reprint author), USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. EM David.Sliney@apg.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU PENNWELL PUBL CO PI NASHUA PA 98 SPIT BROOK RD, NASHUA, NH 03062-2801 USA SN 0740-2511 J9 LASER FOCUS WORLD JI Laser Focus World PD MAR PY 2005 VL 41 IS 3 BP 54 EP 55 PG 2 WC Optics SC Optics GA 913CO UT WOS:000228128300025 ER PT J AU Sliney, DH Franks, JK Lyon, TL AF Sliney, DH Franks, JK Lyon, TL TI Reflections from 193 nm argon-fluoride ophthalmic lasers are not hazardous SO LASERS IN SURGERY AND MEDICINE LA English DT Meeting Abstract CT 25th Annual Meeting of the American-Society-for-Laser-Medicine-and-Surgery CY MAR 30-APR 03, 2005 CL Buena Vista, FL SP Amer Soc Laser Med & Surg C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0196-8092 J9 LASER SURG MED JI Lasers Surg. Med. PD MAR PY 2005 SU 17 MA 147 BP 46 EP 46 PG 1 WC Dermatology; Surgery SC Dermatology; Surgery GA 912GQ UT WOS:000228066000139 ER PT J AU Bhattacharya, G Gerena, L Jiang, SP Werbovetz, KA AF Bhattacharya, G Gerena, L Jiang, SP Werbovetz, KA TI Activity of amidine-containing diphenylureas against P-falciparum SO LETTERS IN DRUG DESIGN & DISCOVERY LA English DT Article DE diamidine; antimalarial; Plasmodium falciparum; plasmepsin; heme assembly ID MALARIA; INHIBITION; PROTEASES; PARASITES; MECHANISM AB Amidine-containing derivatives of the diphenylurea antimalarial lead compound WR268961, a putative plasmepsin inhibitor, were prepared and tested against erythtocyte-stage P. falciparum. Diamidine 8 was the most active compound, displaying IC50 Values of 54 nM and 41 nM versus chloroquine sensitive (D6) and chloroquine resistant (W2) parasites, respectively. C1 Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Werbovetz, KA (reprint author), Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, 500 W 12th Ave, Columbus, OH 43210 USA. EM werbovetz.l@osu.edu RI Werbovetz, Karl/E-4290-2011 NR 17 TC 5 Z9 5 U1 0 U2 0 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1570-1808 J9 LETT DRUG DES DISCOV JI Lett. Drug Des. Discov. PD MAR PY 2005 VL 2 IS 2 BP 162 EP 164 DI 10.2174/1570180053175061 PG 3 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 008ZR UT WOS:000235081400013 ER PT J AU Burgess, EB AF Burgess, EB TI 58 degrees North: The mysterious sinking of the Arctic Rose. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 1 PY 2005 VL 130 IS 4 BP 98 EP 98 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 900VP UT WOS:000227242700131 ER PT J AU Brannon, JM Price, CB Yost, SL Hayes, C Porter, B AF Brannon, JM Price, CB Yost, SL Hayes, C Porter, B TI Comparison of environmental fate and transport process descriptors of explosives in saline and freshwater systems SO MARINE POLLUTION BULLETIN LA English DT Article DE environmental assessment; environmental management; chemical pollution; TNT; RDX; HMX ID DISSOLUTION RATES; TNT; RDX AB Environmental process descriptors are necessary to evaluate the fate and transport of munitions constituents that have been introduced into the environment. An extensive database exists for freshwater environments; however, explosives fate and transport parameters such as dissolution rates, transformation rates, and adsorption of explosives have not been evaluated under both freshwater and saline conditions to determine the applicability of the freshwater data to saline environments. The objective of this study was to determine if freshwater fate and transport processes were similar to those determined under saline water conditions. We evaluated TNT, RDX, and HMX dissolution rates, transformation rates, and adsorption under freshwater and saline conditions in batch tests. Results showed a generally close agreement. Therefore, the existing freshwater database for explosives fate and transport process descriptors can be used in marine environments. Published by Elsevier Ltd. C1 USA, Ctr Res Dev & Engn, Environm Lab, Vicksburg, MS 39180 USA. CSC Corp, Vicksburg, MS 39180 USA. ASI Inc, Huntsville, AL USA. RP USA, Ctr Res Dev & Engn, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Cynthia.L.Price@erdc.usace.army.mil NR 6 TC 22 Z9 22 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0025-326X EI 1879-3363 J9 MAR POLLUT BULL JI Mar. Pollut. Bull. PD MAR PY 2005 VL 50 IS 3 BP 247 EP 251 DI 10.1016/j.marpolbul.2004.10.008 PG 5 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 910FD UT WOS:000227915000012 PM 15757688 ER PT J AU Russell, K Sodhi, RS AF Russell, K Sodhi, RS TI On the design of slider-crank mechanisms. Part I: Multi-phase motion generation SO MECHANISM AND MACHINE THEORY LA English DT Article ID KINEMATIC SYNTHESIS; 4-BAR MECHANISMS; RRSS MECHANISMS AB A method for designing slider-crank mechanisms to achieve multi-phase motion generation applications typically accomplished by adjustable planar four-bar motion generators is presented. The benefit of this method is twofold. First, multiple phases of prescribed rigid body positions are achievable using a mechanism with fewer moving parts than the planar four-bar mechanism. Second, the slider-crank motion generator can achieve phases of prescribed rigid body positions without any physical or automated adjustments of its moving pivots between phases. A slider path that enables the slider-crank motion generator to achieve two phases of prescribed rigid body positions is designed by using 7th order polynomials to connect the moving pivot paths of the follower link of the adjustable planar four-bar motion generator. This polynomial generates smooth radial displacement, velocity, acceleration and jerk profiles with boundary conditions that can be prescribed. The example problem in this work considers a two-phase moving pivot adjustment of a planar four-bar mechanism. (c) 2004 Elsevier Ltd. All rights reserved. C1 New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. USA, Ctr Dev & Engn, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. RP Sodhi, RS (reprint author), New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. EM sodhi@adm.njit.edu NR 24 TC 15 Z9 16 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0094-114X J9 MECH MACH THEORY JI Mech. Mach. Theory PD MAR PY 2005 VL 40 IS 3 BP 285 EP 299 DI 10.1016/j.mechmachtheory.2004.07.009 PG 15 WC Engineering, Mechanical SC Engineering GA 905US UT WOS:000227596600003 ER PT J AU Russell, K Sodhi, RS AF Russell, K Sodhi, RS TI On the design of slider-crank mechanisms. Part II: Multi-phase path and function generation SO MECHANISM AND MACHINE THEORY LA English DT Article AB A method to design slider-crank mechanisms to achieve multi-phase path and function generation applications typically accomplished by adjustable planar four-bar mechanisms is presented. The benefit of this method is twofold. First, multiple phases of prescribed coupler curve points or crank and follower displacement angles are achievable using a mechanism with fewer moving parts than the planar four-bar mechanism. Second, the slider-crank mechanism can achieve these phases of prescribed values without any physical or automated adjustments of its moving pivots between phases. A slider path that enables the slider-crank to achieve two phases of prescribed coupler curve points or crank and follower displacement angles is designed by using seventh order polynomials to connect the moving pivot paths of the follower link of the adjustable planar four-bar mechanism. This polynomial generates smooth radial displacement, velocity, acceleration and jerk profiles with boundary conditions that can be prescribed. The example problems in this work considers a two-phase moving pivot adjustment of a planar four-bar mechanism. (c) 2004 Elsevier Ltd. All rights reserved. C1 New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. USA, Ctr Dev & Engn, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. RP Sodhi, RS (reprint author), New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. EM sodhi@adm.njit.edu NR 11 TC 18 Z9 18 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0094-114X J9 MECH MACH THEORY JI Mech. Mach. Theory PD MAR PY 2005 VL 40 IS 3 BP 301 EP 317 DI 10.1016/j.mechmachtheory.2004.07.010 PG 17 WC Engineering, Mechanical SC Engineering GA 905US UT WOS:000227596600004 ER PT J AU Carroll, JF Klun, JA Debboun, M AF Carroll, JF Klun, JA Debboun, M TI Repellency of deet and SS220 applied to skin involves olfactory sensing by two species of ticks SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article DE Amblyomma americanum; Ixodes scapularis; blacklegged tick; deet; fingertip bioassay; lone star tick; N, N-diethyl-3-methylbenzamide; SS220,(1S, 2 ' S)-2-methylpiperidinyl-3-cyclohexene-1-carboxamide ID AMBLYOMMA-AMERICANUM ACARI; LONE STAR TICK; PERSONAL PROTECTION; PRESSURIZED SPRAYS; IXODES-SCAPULARIS; FIELD-EVALUATION; IXODIDAE; PERMETHRIN; EFFICACY; AI3-37220 AB Responses of host-seeking nymphs of the blacklegged tick, Ixodes scapularis Say and lone star tick, Amblyomma americanum (Linnaeus) (Acari: Ixodidae) to the repellents N,N-diethyl-3-methylbenzamide (deet) and (1S, 2'S)-2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) were studied using fingertip laboratory bioassays. Ethanol solutions of both compounds applied to the skin strongly repelled both species of ticks at 0.8 and 1.6 mumole of compound/cm(2) skin. The ticks were also repelled when two layers of organdie cloth covered the portion of a finger treated with either deet or SS220. Gas chromatographic analyses of the outer layer of cloth that had covered skin treated with 1.6 mumole compound/cm(2) skin revealed only 0.1 nmole SS220/cm(2) cloth and 2.8 nmole deet/cm(2) cloth. However, in bioassays in which a single layer of cloth was treated with a dose of deet or SS220 equivalent to the amount found in the outer layer of cloth, ticks were not repelled. Results unequivocally demonstrated that these ticks responded to the repellents in the vapour phase when repellent treated skin was covered with cloth to obviate tactile contact with them, and made it clear that the ticks detect the repellents by olfactory sensing. Heretofore, the mode of action of deet and SS220 was unclear. C1 ARS, USDA, APDL, Chem Affecting Insect Behav Lab,Beltsville Agr Re, Beltsville, MD 20705 USA. USA, Ctr Hlth Promot & Prevent Med S, Ft McPherson, GA USA. RP Carroll, JF (reprint author), ARS, USDA, APDL, Chem Affecting Insect Behav Lab,Beltsville Agr Re, BARC-E,Bldg 1040, Beltsville, MD 20705 USA. EM jcarroll@anri.barc.usda.gov NR 20 TC 34 Z9 36 U1 4 U2 11 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD MAR PY 2005 VL 19 IS 1 BP 101 EP 106 DI 10.1111/j.0269-283X.2005.00559.x PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 902XN UT WOS:000227390100014 PM 15752184 ER PT J AU Harrison, SA Bacon, BR AF Harrison, SA Bacon, BR TI Relation of hemochromatosis with hepatocellular carcinoma: epidemiology, natural history, pathophysiology, screening, treatment, and prevention SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Review ID HEREDITARY HEMOCHROMATOSIS; GENETIC HEMOCHROMATOSIS; TRANSFERRIN RECEPTOR; IRON-ABSORPTION; IDIOPATHIC HEMOCHROMATOSIS; CANCER-RISK; DNA-DAMAGE; DUODENAL EXPRESSION; CLINICAL EXPRESSION; NONCIRRHOTIC LIVER AB Hereditary hemochromatosis is a common inherited disorder of iron metabolism affecting about I out of 250 individuals of Northern European descent. Some patients develop progressive iron overload and cirrhosis. These individuals are at risk of developing hepatocellular carcinoma. With increasing clinical recognition, hemochromatosis should be diagnosed earlier and progression to cirrhosis and hepatocellular carcinoma should be minimized. This article includes an overview of hereditary hemochromatosis with a focus on the relationship to hepatocellular carcinoma in reference to epidemiology, natural history, pathophysiology, screening, treatment, and prevention. C1 St Louis Univ, Sch Med, Ctr Liver, Div Gastroenterol & Hepatol, St Louis, MO 63110 USA. Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. RP Bacon, BR (reprint author), St Louis Univ, Sch Med, Ctr Liver, Div Gastroenterol & Hepatol, 3635 Vista Ave, St Louis, MO 63110 USA. EM baconbr@slu.edu NR 119 TC 25 Z9 26 U1 0 U2 8 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD MAR PY 2005 VL 89 IS 2 BP 391 EP + DI 10.1016/j.mcna.2004.08.005 PG 20 WC Medicine, General & Internal SC General & Internal Medicine GA 894VD UT WOS:000226818800008 PM 15656932 ER PT J AU Best, RW AF Best, RW TI Peremptory challenges in military criminal justice practice: It is time to challenge them off SO MILITARY LAW REVIEW LA English DT Article ID SELECTION; COURT; JURY; MEMBERS C1 USA, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. RP Best, RW (reprint author), USA, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. NR 31 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2005 VL 183 BP 1 EP 65 PG 65 WC Law SC Government & Law GA 920NF UT WOS:000228696700001 ER PT J AU Ball, MJA AF Ball, MJA TI Imperial hubris: Why the West is losing the war on terror SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Legal Ctr & Sch, Judge Advoacte Officer Grad Course 53, Charlottesville, VA USA. RP Ball, MJA (reprint author), USA, Judge Advocate Gen Legal Ctr & Sch, Judge Advoacte Officer Grad Course 53, Charlottesville, VA USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2005 VL 183 BP 187 EP 198 PG 12 WC Law SC Government & Law GA 920NF UT WOS:000228696700006 ER PT J AU Cheney, MJE AF Cheney, MJE TI Washington's crossing SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Officer Grad Course 53, Charlottesville, VA USA. RP Cheney, MJE (reprint author), USA, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Officer Grad Course 53, Charlottesville, VA USA. NR 22 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2005 VL 183 BP 199 EP 207 PG 9 WC Law SC Government & Law GA 920NF UT WOS:000228696700007 ER PT J AU Pittman, PR Norris, SL Coonan, KM McKee, KT AF Pittman, PR Norris, SL Coonan, KM McKee, KT TI An assessment of health status among medical research volunteers who served in the project whitecoat program at Fort Detrick, Maryland SO MILITARY MEDICINE LA English DT Article AB Between 1954 and 1973, more than 2,000 men entering military service as conscientious objectors participated in Project Whitecoat as medical research volunteers for the Army's biological warfare defense program. An assessment of self-reported, current health status among 358 "exposed" individuals and 164 unexposed control subjects found no conclusive evidence that receipt of investigational agents was related to adverse health outcomes. No differences in current overall health, current exercise levels, self-reported symptoms, and self-reported medical conditions were seen between the study groups. Possible associations were seen between exposure to antibiotics or other biological agents and self-reported asthma (13.0% vs. 2.4%, relative risk [RR] = 6.00, 95% confidence interval [CI] = 1.03-34.90, p = 0.050), as well as between receipt of tularemia vaccine(s) and self-reported asthma (13.3% vs. 2.4%, RR = 6.15, 95% CI = 1.03-36.70, p = 0.049) and increased frequency/severity of headaches (35.6% vs. 18.3%, RR = 2.46, 95% CI = 0.99-6.15, p = 0.074). However, the size of the population under study was insufficient to assert with confidence that these statistical associations are real. C1 USA, Med Res Inst Infect Dis, Sci Applicat Int Corp, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Camber Corp, Ft Detrick, MD 21702 USA. RP Pittman, PR (reprint author), USA, Med Res Inst Infect Dis, Sci Applicat Int Corp, 1425 Porter St, Ft Detrick, MD 21702 USA. EM phillip.pittman@amedd.army.mil NR 8 TC 7 Z9 7 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2005 VL 170 IS 3 BP 183 EP 187 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 019JI UT WOS:000235831000002 PM 15828690 ER PT J AU Buckingham, RS Whitwell, KJ Lee, RB AF Buckingham, RS Whitwell, KJ Lee, RB TI Cost analysis of military eye injuries in fiscal years 1988-1998 SO MILITARY MEDICINE LA English DT Article AB Army, Navy, and Air Force safety center ground eye injuries were evaluated from fiscal year 1988 through fiscal year 1998. The U.S. Army Safety Center data revealed that the average Army military eye injury mishap caused a loss of 6.1 days from work, at a cost averaging $9,724. The U.S. Navy Safety Center data showed that the average Navy military eye injury mishap caused a loss of 5.9 days from work, at a cost averaging $4,222. The Air Force Safety Center data revealed that the average Air Force eye injury mishap caused a loss of 4.7 days from work, at a cost averaging $3,196. Comparing safety center data with Defense Medical Surveillance System data exposed an under-reporting of safety center data by at least 250%. To improve accurate meaningful data collection, an automated eye injury collection system should be initiated. C1 Ferris State Univ, Coll Optometry, Big Rapids, MI 49307 USA. Naval Aerosp Med Inst, Pensacola, FL 32508 USA. USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21020 USA. RP Buckingham, RS (reprint author), Ferris State Univ, Coll Optometry, Big Rapids, MI 49307 USA. NR 7 TC 5 Z9 6 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2005 VL 170 IS 3 BP 196 EP 200 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 019JI UT WOS:000235831000005 PM 15828693 ER PT J AU Erickson, JC Ellenbogen, RG Khajevi, K Mulligan, L Ford, GC Jabbari, B AF Erickson, JC Ellenbogen, RG Khajevi, K Mulligan, L Ford, GC Jabbari, B TI Temporal lobectomy for refractory epilepsy in the US military SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 56th Annual Meeting of the American-Epilepsy-Society CY DEC 06-11, 2002 CL SEATTLE, WA SP Amer Epilepsy Soc ID QUALITY-OF-LIFE; LOBE EPILEPSY; FOLLOW-UP; SURGERY; SEIZURES AB Objectives: To determine the characteristics, seizure outcomes, and quality-of-life outcomes for military beneficiaries undergoing partial temporal lobectomy for refractory epilepsy at the only U.S. military medical center with a comprehensive epilepsy surgery program. Methods: The records of all 84 patients treated with partial temporal lobectomy between 1986 and 2000 at Walter Reed Army Medical Center were retrospectively reviewed. Outcome measures included seizure frequency according to the Engel classification system, driving, employment, anticonvulsant use, and military service. Results: The study cohort consisted of 72 military dependents, 10 active duty military members, and 2 military retirees. Two years after surgery, 65 (92%) of 71 patients had seizure improvement (Engel classes I-III) and 46 (66%) of 71 had seizure remission (Engel class I). Driving and employment rates increased after surgery, whereas anticonvulsant use decreased. Five (50%) of 10 active duty patients achieved seizure remission postoperatively and continued to serve in the Armed Forces. Active duty patients had a later age of seizure onset, shorter duration of epilepsy, and greater proportion of lesional epilepsy, compared with nonactive duty patients. Conclusions: Epilepsy surgery outcomes in the U.S. military are similar to those reported from nonmilitary centers, with the majority of patients experiencing seizure remission and improvements in quality-of-life measures. Complete seizure remission after successful anterior temporal lobectomy enables some active duty military members to continue service in the U.S. Armed Forces. C1 Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. RP Erickson, JC (reprint author), Madigan Army Med Ctr, Neurol Serv, Tacoma, WA 98431 USA. NR 16 TC 7 Z9 8 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2005 VL 170 IS 3 BP 201 EP 205 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 019JI UT WOS:000235831000006 PM 15828694 ER PT J AU Statler, JD Tempel, CG Harcke, HT AF Statler, JD Tempel, CG Harcke, HT TI Computed tomography of craniofacial trauma at a combat support hospital in Afghanistan SO MILITARY MEDICINE LA English DT Article ID OPERATION DESERT-STORM; FEBRUARY 20; WOUNDS; CORPS; CT AB Complex craniofacial injuries are encountered among both soldiers and civilians in combat zones. Computed tomography is a necessary and effective tool for the evaluation and treatment of these injuries in the forward-deployed combat support hospital. C1 Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Surg, Oral & Maxillofacial Surg Serv, Washington, DC 20307 USA. RP Statler, JD (reprint author), Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. NR 5 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2005 VL 170 IS 3 BP 206 EP 210 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 019JI UT WOS:000235831000007 PM 15828695 ER PT J AU Hensel, KS Person, DA Schaefer, RA Burkhalter, WE AF Hensel, KS Person, DA Schaefer, RA Burkhalter, WE TI An internet-based referral/consultation system for the US-associated Pacific Islands: Its contribution to orthopedic graduate medical education at Tripler Army Medical Center SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 44th Annual Meeting of the Society-of-Military-Orthopedic-Surgeons CY DEC 09-14, 2002 CL San Diego, CA SP Soc Mil Orthoped Surg AB To evaluate the benefit of the Pacific Island Health Care Project (PIHCP) to our orthopedic graduate medical education program, we performed a retrospective review of our 8-year operative experience with patients referred through this program. Between July 1994 and June 2002, 69 patients underwent 79 orthopedic operative procedures. Patients were categorized by primary diagnosis, anatomic site involved, and surgical treatment rendered. Because many of the patients referred from the PIHCP with tumors were noted to have either unusually large lesions or advanced-stage disease, further analyses of tumor stage and pathologic grade were made. Seven of the 14 oncologic cases surgically treated in our department in the past 8 years were referrals from the PIHCP. Unique operative procedures performed for these tumor patients included one forequarter amputation, one hip disarticulation, one hemipelvectomy, two partial scapulectomies, and one distal ulna excision. We conclude that the PIHCP referrals provide an important and relatively unique contribution to the clinical and operative experience of our orthopedic residents. These patients from the Pacific basin also enhance our orthopedic graduate medical education program by exposing our residents to the special socioeconomic and cultural issues related to caring for people from developing insular countries. C1 Tripler Army Med Ctr, Dept Surg, Orthopaed Serv, Honolulu, HI 96859 USA. RP Hensel, KS (reprint author), Tripler Army Med Ctr, Dept Surg, Orthopaed Serv, Honolulu, HI 96859 USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2005 VL 170 IS 3 BP 214 EP 218 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 019JI UT WOS:000235831000009 PM 15828697 ER PT J AU Niederhauser, VP Maddock, J LeDoux, F Arnold, M AF Niederhauser, VP Maddock, J LeDoux, F Arnold, M TI Building strong and ready army families: A multirisk reduction health promotion pilot study SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT DoD Population Health and Health Promotion Conference CY AUG 13, 2002 CL BALTIMORE, MD ID MULTIETHNIC POPULATIONS; CANCER PREVENTION; UNITED-STATES; WORKING-CLASS; MILITARY; STRESS; SYSTEM; DEATH; MODEL AB A quasi-experimental prospective study was conducted to assess the stage of change progression and elimination of unhealthy behaviors among active duty Army soldiers and their spouses (N = 245) before and after attending a community-based wellness program. Significant differences in stage progression between the intervention group and a comparison group was seen in the fitness (p = 0.05) and communication risk categories (p = 0.03) immediately after the intervention; significant differences in stage progression in fitness (p = 0.05) and spirituality (p = 0.005) risk categories 6 months after baseline. There was a significant increase in seat belt use (p = 0.008), a decrease in reported tobacco use (p < 0.05), and a reduction in family stress (p = 0.06) and personal stress (p < 0.02) in the intervention group. Targeting multiple behavior changes and risk reduction in a single intervention program presents several challenges. In this pilot study, there were many positive nonsignificant trends in risk reduction that might translate into significant changes with a larger sample. C1 Univ Hawaii, Sch Nursing & Dent Hyg, Honolulu, HI 96822 USA. Univ Hawaii, Sch Med, Dept Publ Hlth, Honolulu, HI 96822 USA. Tripler Army Med Ctr, Tripler, HI 96859 USA. RP Niederhauser, VP (reprint author), Univ Hawaii, Sch Nursing & Dent Hyg, 2528 McCarthy Mall, Honolulu, HI 96822 USA. RI Maddock, Jason/A-9226-2008 OI Maddock, Jason/0000-0002-1119-0300 NR 20 TC 6 Z9 6 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2005 VL 170 IS 3 BP 227 EP 233 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 019JI UT WOS:000235831000012 PM 15828700 ER PT J AU Kiang, JG Ives, JA Jonas, WB AF Kiang, JG Ives, JA Jonas, WB TI External bioenergy-induced increases in intracellular free calcium concentrations are mediated by Na+/Ca2+ exchanger and L-type calcium channel SO MOLECULAR AND CELLULAR BIOCHEMISTRY LA English DT Article DE lymphoid cells; intracellular calcium; intracellular signal; calcium channel; Na+/Ca2+ exchanger; bioenergy ID NA+-CA2+ EXCHANGE; CELLS; KDA AB External bioenergy (EBE, energy emitted from a human body) has been shown to increase intracellular calcium concentration ([Ca2+](i), an important factor in signal transduction) and regulate the cellular response to heat stress in cultured human lymphoid Jurkat T cells. In this study, we wanted to elucidate the underlying mechanisms. A bioenergy specialist emitted bioenergy sequentially toward tubes of cultured Jurkat T cells for one 15-minute period in buffers containing different ion compositions or different concentrations of inhibitors. [Ca2+](i) was measured spectrofluorometrically using the fluorescent probe fura-2. The resting [Ca2+](i) in Jurkat T cells was 70 +/- 3 nM (n = 130) in the normal buffer. Removal of external calcium decreased the resting [Ca2+](i) to 52 +/- 2 nM (n = 23), indicating that [Ca2+] entry from the external source is important for maintaining the basal level of [Ca2+](i). Treatment of Jurkat T cells with EBE for 15 min increased [Ca2+](i) by 30 +/- 5% (P < 0.05, Student t-test). The distance between the bioenergy specialist and Jurkat T cells and repetitive treatments of EBE did not attenuate [Ca2+](i) responsiveness to EBE. Removal of external Ca2+ or Na+, but not Mg2+, inhibited the EBE-induced increase in [Ca2+](i). Dichlorobenzamil, an inhibitor of Na+/Ca2+ exchangers, also inhibited the EBE-induced increase in [Ca2+](i) in a concentration-dependent manner with an IC50 of 0.11 +/- 0.02 nM. When external [K+] was increased from 4.5 mM to 25 mM, EBE decreased [Ca2+](i). The EBE-induced increase was also blocked by verapamil, an L-type voltage-gated Ca2+ channel blocker. These results suggest that the EBE-induced [Ca2+](i) increase may serve as an objective means for assessing and validating bioenergy effects and those specialists claiming bioenergy capability. The increase in [Ca2+](i) is mediated by activation of Na+/Ca2+ exchangers and opening of L-type voltage-gated Ca2+ channels. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA. Samueli Inst Informat Biol, Alexandria, VA USA. RP Kiang, JG (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, 503 Robert Grant Ave,Room 1N07, Silver Spring, MD 20910 USA. EM Juliann.Kiang@na.amedd.army.mil NR 46 TC 12 Z9 13 U1 2 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0300-8177 J9 MOL CELL BIOCHEM JI Mol. Cell. Biochem. PD MAR PY 2005 VL 271 IS 1-2 BP 51 EP 59 DI 10.1007/s11010-005-3615-x PG 9 WC Cell Biology SC Cell Biology GA 914OJ UT WOS:000228236900006 PM 15881655 ER PT J AU Li, C Wilkerson, RC Fonseca, DM AF Li, C Wilkerson, RC Fonseca, DM TI Isolation of polymorphic microsatellite markers from the malaria vector Anopheles marajoara (Diptera : Culicidae) SO MOLECULAR ECOLOGY NOTES LA English DT Article DE Nyssorhynchus; neotropical; sex linked ID POLYMERASE CHAIN-REACTION; NYSSORHYNCHUS ALBITARSIS AB Microsatellite-containing regions were isolated and characterized in Anopheles (Nyssorhynchus) marajoara, a primary vector of malaria parasites in northeastern Amazonia, Brazil. An enrichment protocol yielded 500 positive clones. We designed primers to amplify 40 unique microsatellites, 11 of which amplified cleanly and were polymorphic. A survey of 323 individuals showed that these loci are highly variable with the number of alleles ranging from 11 to 52, and expected heterozygosity ranging from 0.64 to 0.95. These markers will be useful for studies of population structure and intraspecific variation in A. marajoara. C1 Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. Acad Nat Sci, Philadelphia, PA 19103 USA. RP Wilkerson, RC (reprint author), Walter Reed Biosyst Unit, Museum Supporting Ctr, 4210 Silver Hill Rd, Suitland, MD 20746 USA. EM wilkersonr@si.edu RI Fonseca, Dina/B-9951-2011 OI Fonseca, Dina/0000-0003-4726-7100 NR 10 TC 3 Z9 3 U1 0 U2 0 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 1471-8278 J9 MOL ECOL NOTES JI Mol. Ecol. Notes PD MAR PY 2005 VL 5 IS 1 BP 65 EP 67 DI 10.1111/j.1471-8286.2004.00835.x PG 3 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA 905VJ UT WOS:000227598500022 ER PT J AU Krupin, T Liebmann, JM Greenfield, DS Rosenberg, LF Ritch, R Yang, JW AF Krupin, T Liebmann, JM Greenfield, DS Rosenberg, LF Ritch, R Yang, JW CA Low Pressure Glaucoma Study Grp TI The Low-Pressure Glaucoma Treatment Study (LoGTS) SO OPHTHALMOLOGY LA English DT Article ID LOW-TENSION GLAUCOMA; OPEN-ANGLE GLAUCOMA; BRIMONIDINE TARTRATE 0.2-PERCENT; OCULAR HYPERTENSION TREATMENT; VISUAL-FIELD DEFECTS; REDUCED INTRAOCULAR-PRESSURES; CENTRAL CORNEAL THICKNESS; BEAVER-DAM EYE; TIMOLOL 0.5-PERCENT; UNTREATED PATIENTS AB Objective: The Low-Pressure Glaucoma Treatment Study (LoGTS) seeks to evaluate visual field stability in low-pressure glaucoma patients randomized to intraocular pressure reduction in both eyes with topical twice daily brimonidine tartrate 0.2% versus twice daily timolol maleate 0.5%. This article describes the LoGTS design and presents baseline characteristics of the subjects. Design: Randomized, multicenter, double-masked clinical trial. Participants: Low-pressure glaucoma patients 30 years of age or older were identified. Exclusion criteria included an untreated pressure of more than 21 mmHg, advanced visual field loss, and contraindications to study medications. Interventions: Randomization of both eyes to double-masked monotherapy with brimonidine or timolol. Follow-up visits included Humphrey 24-2 full-threshold perimetry, tonometry every 4 months, and annual optic disc photography. Main Outcome Measure: Progression of visual field loss. Results: One hundred ninety patients were randomized between 1998 and 2000. Mean age (+/-standard deviation) was 64.9+/-10.7 years. Women comprised 59.5% of the patients. Fifty-three patients (27.9%) had unilateral field loss. The 137 patients with bilateral field loss were older than those with unilateral field loss: 65.7 versus 62.3 years of age (P<0.05). Mean untreated diurnal intraocular pressures were similar between the eyes of the bilateral patients (mean, 15.5 mmHg in both eyes) and unilateral patients (mean, 16.0 mmHg in field loss vs. 15.6 mmHg in fellow eyes). Visual field mean deviation for all eyes was -5.4+/-4.7 decibels. Central corneal thickness in 168 phakic patients was 543+/-35 mum (range, 435-655 mum); thickness was less than 500 mum in 15 eyes and was more than 600 mum in 11 eyes. Mean vertical cup-to-disc ratio for all eyes was 0.67+/-0.15. Unilateral field loss patients had a larger cup-to-disc ratio in the field loss eye (0.75+/-0.12) than the fellow eye with a normal field (0.60+/-0.17, P<0.0001). Disc hemorrhage was present at baseline in 29 patients (32 eyes). Conclusions: The LoGTS; was successfully able to recruit and enroll patients with open-angle glaucoma and statistically normal intraocular pressure into a longitudinal, prospective clinical trial comparing 2 different glaucoma medications. Baseline characteristics of note were a preponderance of females, unilateral field loss in 27.9% of participants, and frequent optic disc hemorrhage. Central corneal thickness had a normal distribution and did not account for false low-pressure measurements in LoGTS patients. (C) 2005 by the American Academy of Ophthalmology. C1 Univ Eye Specialists, Chicago, IL 60611 USA. Northwestern Univ, Feinberg Sch Med, Dept Ophthalmol, Chicago, IL 60611 USA. Manhattan Eye Ear & Throat Hosp, New York, NY 10021 USA. NYU, Sch Med, New York, NY 10021 USA. Univ Miami, Sch Med, Bascom Palmer Eye Inst, Palm Beach Gardens, FL USA. New York Eye & Ear Infirm, New York, NY 10003 USA. New York Med Coll, Valhalla, NY 10595 USA. Wills Eye Hosp & Res Inst, Philadelphia, PA USA. Indiana Univ, Indianapolis, IN 47405 USA. Baylor Coll Med, Cullen Eye Inst, Houston, TX 77030 USA. Brooke Army Med Ctr, San Antonio, TX USA. Univ Florida, Gainesville, FL USA. Univ Chicago, Chicago, IL 60637 USA. Little Rock Eye Clin, Little Rock, AR USA. Wheaton Eye Clin, Wheaton, IL USA. Univ Penn, Scheie Eye Inst, Philadelphia, PA 19104 USA. RP Krupin, T (reprint author), Univ Eye Specialists, 676 N St Clair,Suite 320, Chicago, IL 60611 USA. NR 61 TC 58 Z9 60 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD MAR PY 2005 VL 112 IS 3 BP 376 EP 385 DI 10.1016/j.ophtha.2004.10.034 PG 10 WC Ophthalmology SC Ophthalmology GA 900IY UT WOS:000227209800003 PM 15745762 ER PT J AU Ding, X Cloud, GL Raju, BB AF Ding, X Cloud, GL Raju, BB TI Noise tolerance of the improved max-min scanning method for phase determination SO OPTICAL ENGINEERING LA English DT Article DE phase shifting algorithm; noise tolerance; interferometry; digital speckle pattern interferometry; calibration of phase shifting AB In general, inherent susceptibility to environmental noise has tended to retard adoption of interference methods by industry. Phase shifting is a key step in optical interference techniques of measurement. An improved max-min scanning (IMMS) method for phase determination was reported in 2004, but the environmental noise tolerance of this approach relative to other methods has been an open question. We discuss the noise tolerance of the IMMS method. Numerical simulations and simple experiments show that the method has good tolerance to some specific environmental vibration inputs, including high-frequency noise and small-amplitude low-frequency noise. The simplified data acquisition and improved noise tolerance of IMMS broadens potential applications of interferometry, particularly digital speckle pattern interferometry in the factory and the field. Another benefit of the IMMS method is an online technique to calibrate and test the phase shifter in real time. This idea is described and demonstrated. (c) 2005 Society of Photo-Optical Instrumentation Engineers. C1 Michigan State Univ, Dept Mech Engn, E Lansing, MI 48824 USA. USA, Tank Automot Command, Warren, MI 48397 USA. RP Ding, X (reprint author), Michigan State Univ, Dept Mech Engn, E Lansing, MI 48824 USA. EM dingxu@msu.edu NR 0 TC 2 Z9 2 U1 0 U2 1 PU SPIE-INT SOCIETY OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAR PY 2005 VL 44 IS 3 AR 035605 DI 10.1117/1.1873412 PG 5 WC Optics SC Optics GA 974KK UT WOS:000232590100032 ER PT J AU Richardson, WH Barry, JD Tong, TC Williams, SR Clark, RF AF Richardson, WH Barry, JD Tong, TC Williams, SR Clark, RF TI Rattlesnake envenomation to the face of an infant SO PEDIATRIC EMERGENCY CARE LA English DT Article DE crotaline; envenomation; infant; air-way; edema ID BITE AB Background: Mortality from rattlesnake envenomation in the United States is rare. Despite approximately 8000 crotaline (pit vipers) bites annually, it is estimated that only 10 to 15 deaths occur. Besides direct intravascular envenomation and anaphylaxis, bites to the head and neck may account for some of these rare fatalities. We report a pediatric case of severe facial envenomation requiring emergent intubation and antivenom administration. Case Report: A 14-month-old female toddler was envenomated by a Southern Pacific rattlesnake (Crotalus viridis helleri) above the right upper lip while playing in her backyard. Rapid swelling and ecchymosis developed, and the patient was airlifted to a pediatric tertiary care hospital. Within 3 hours, stridorous respirations complicated by significant facial and oropharyngeal edema necessitated emergent orotracheal intubation. A total of 16 vials of FabAV [Crotalidae Polyvalent Immune Fab (ovine) antivenom] were administered over the next 24 hours. The child gradually improved and was successfully extubated 5 days later. A 3-month follow-up demonstrated no significant cosmetic facial abnormalities. Conclusion: Crotaline bites to the head and neck have the potential for significant swelling and airway compromise. Facial bites, anaphylaxis, and rare intravascular envenomation may account for many of the fatalities from rattlesnake envenomation. Early intubation may be required to maintain airway patency. C1 Univ S Carolina, Coll Pharm, Palmetto Poison Ctr, Columbia, SC 29208 USA. Palmetto Richland Mem Hosp, Dept Emergency Med, Columbia, SC 29208 USA. Brooke Army Med Ctr, San Antonio, TX USA. Univ Calif San Diego, San Diego Med Ctr, Dept Emergency Med, Div Med Toxicol, San Diego, CA 92103 USA. RP Richardson, WH (reprint author), Univ S Carolina, Coll Pharm, Palmetto Poison Ctr, Columbia, SC 29208 USA. EM whrichardson@sc.rr.com NR 14 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0749-5161 J9 PEDIATR EMERG CARE JI Pediatr. Emerg. Care PD MAR PY 2005 VL 21 IS 3 BP 173 EP 176 PG 4 WC Emergency Medicine; Pediatrics SC Emergency Medicine; Pediatrics GA 906PB UT WOS:000227653100006 PM 15744196 ER PT J AU Arias, RS Netherland, MD Scheffler, BE Puri, A Dayan, FE AF Arias, RS Netherland, MD Scheffler, BE Puri, A Dayan, FE TI Molecular evolution of herbicide resistance to phytoene desaturase inhibitors in Hydrilia verticillata and its potential use to generate herbicide-resistant crops SO PEST MANAGEMENT SCIENCE LA English DT Article; Proceedings Paper CT Symposium on Herbicide-Resistant Crops from Biotechnology held at the ACS 227th National Meeting CY MAR 29-30, 2004 CL Anaheim, CA SP Amer Chem Soc, Agrochem Div DE non-indigenous species; invasive species; somatic mutations; herbicide resistance; aquatic weed; molecular adaptation ID POLYMORPHIC DNA ANALYSIS; DIOECIOUS HYDRILLA; CAROTENOID BIOSYNTHESIS; LF ROYLE; MONOECIOUS HYDRILLA; ISOENZYME PATTERNS; FUNGAL PATHOGEN; UNITED-STATES; PHENETIC RELATIONSHIPS; ACETOLACTATE SYNTHASE AB Hydrilla [Hydrilla verticillata (Lf) Royle] is one of the most serious invasive aquatic weed problems in the USA. This plant possesses numerous mechanisms of vegetative reproduction that enable it to spread very rapidly. Management of this weed has been achieved by the systemic treatment of water bodies with the herbicide fluridone. At least three dioecious fluridone-resistant biotypes of hydrilla with two- to fivefold higher resistance to the herbicide than the wild-type have been identified. Resistance is the result of one of three independent somatic mutations at the arginine 304 codon of the gene encoding phytoene desaturase, the molecular target site of fluridone. The specific activities of the three purified phytoene desaturase variants are similar to the wild-type enzyme. The appearance of these herbicide-resistant biotypes may jeopardize the ability to control the spread of this non-indigenous species to other water bodies in the southern USA. The objective of this paper is to provide general information about the biology and physiology of this aquatic weed in relation to its recent development of resistance to the herbicide fluridone, and to discuss how this discovery might lead to a new generation of herbicide-resistant crops. (C) 2005 Society of Chemical Industry. C1 Univ Mississippi, USDA, ARS, Nat Prod Utilizat Res Unit, University, MS 38677 USA. USACE ERDC Env Lab, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. Univ Florida, Dept Agron, Gainesville, FL 32611 USA. RP Dayan, FE (reprint author), Univ Mississippi, USDA, ARS, Nat Prod Utilizat Res Unit, POB 8048, University, MS 38677 USA. EM fdayan@msa-oxford.ars.usda.gov RI Dayan, Franck/A-7592-2009 OI Dayan, Franck/0000-0001-6964-2499 NR 102 TC 34 Z9 36 U1 3 U2 11 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1526-498X J9 PEST MANAG SCI JI Pest Manag. Sci. PD MAR PY 2005 VL 61 IS 3 BP 258 EP 268 DI 10.1002/ps.1022 PG 11 WC Agronomy; Entomology SC Agriculture; Entomology GA 902GH UT WOS:000227342100008 PM 15668922 ER PT J AU Allegrini, P Grigolini, P Palatella, L Rosa, A West, BJ AF Allegrini, P Grigolini, P Palatella, L Rosa, A West, BJ TI Non-Poisson processes: regression to equilibrium versus equilibrium correlation functions SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Article DE stochastic processes; non-Poisson processes; liouville and liouville-like equations; correlation function; regression to equilibrium ID ANOMALOUS LOCAL VISCOELASTICITY; RANDOM-WALKS; REGULAR TRANSPORT; EXTERNAL FIELDS; CHAOTIC SYSTEMS; ACTIN NETWORKS; BIASED MAPS; DIFFUSION; SUBDIFFUSION; CROSSOVER AB We study the response to perturbation of non-Poisson dichotomous fluctuations that generate super-diffusion. We adopt the Liouville perspective and with it a quantum-like approach based on splitting the density distribution into a symmetric and an anti-symmetric component. To accomodate the equilibrium condition behind the stationary correlation function, we study the time evolution of the anti-symmetric component, while keeping the symmetric component at equilibrium. For any realistic form of the perturbed distribution density we expect a breakdown of the Onsager principle, namely, of the property that the subsequent regression of the perturbation to equilibrium is identical to the corresponding equilibrium correlation function. We find the directions to follow for the calculation of higher-order correlation functions, an unsettled problem, which has been addressed in the past by means of approximations yielding quite different physical effects. (C) 2004 Elsevier B.V. All rights reserved. C1 Ecole Polytech Fed Lausanne, Inst Math B, Fac Sci Base, CH-1015 Lausanne, Switzerland. INFM, Unita Como, I-22100 Como, Italy. Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. Univ Pisa, Dipartimento Fis, I-56127 Pisa, Italy. INFM, I-56127 Pisa, Italy. CNR, Ist Proc Chim Fis, Area Ric Pisa, I-56124 Pisa, Italy. Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy. Univ Roma La Sapienza, INFM, Ctr Stat Mech & Complex, I-00185 Rome, Italy. USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. RP Ecole Polytech Fed Lausanne, Inst Math B, Fac Sci Base, CH-1015 Lausanne, Switzerland. EM angelo.rosa@epfl.ch RI Allegrini, Paolo/C-1876-2012; Rosa, Angelo/C-2056-2015; OI Allegrini, Paolo/0000-0002-5476-9005; Rosa, Angelo/0000-0002-9627-2486; Palatella, Luigi Nicola/0000-0003-0075-8287 NR 28 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 EI 1873-2119 J9 PHYSICA A JI Physica A PD MAR 1 PY 2005 VL 347 BP 268 EP 288 DI 10.1016/j.physa.2004.08.004 PG 21 WC Physics, Multidisciplinary SC Physics GA 890XG UT WOS:000226543900017 ER PT J AU Ballato, J Ballato, A Figotin, A Vitebskiy, I AF Ballato, J Ballato, A Figotin, A Vitebskiy, I TI Frozen light in periodic stacks of anisotropic layers SO PHYSICAL REVIEW E LA English DT Article ID PROPAGATION MATRIX-METHOD; MEDIA; OPTICS AB We consider a plane electromagnetic wave incident on a periodic stack of dielectric layers. One of the alternating layers has an anisotropic refractive index with an oblique orientation of the principal axis relative to the normal to the layers. It was shown recently that an obliquely incident light, upon entering such a periodic stack, can be converted into an abnormal axially frozen mode with drastically enhanced amplitude and zero normal component of the group velocity. The stack reflectivity at this point can be very low, implying nearly total conversion of the incident light into the frozen mode with huge energy density, compared to that of the incident light. Supposedly, the frozen mode regime requires strong birefringence in the anisotropic layers-by an order of magnitude stronger than that available in common anisotropic dielectric materials. In this paper we show how to overcome the above problem by exploiting higher frequency bands of the photonic spectrum. We prove that a robust frozen mode regime at optical wavelengths can be realized in stacks composed of common anisotropic materials, such as YVO4, LiNbO3, CaCO3, and the like. C1 Clemson Univ, Sch Mat Sci & Engn, COMSET, Clemson, SC 29634 USA. USA, CERDEC, Ft Monmouth, NJ 07703 USA. Univ Calif Irvine, Dept Math, Irvine, CA 92697 USA. RP Ballato, J (reprint author), Clemson Univ, Sch Mat Sci & Engn, COMSET, Clemson, SC 29634 USA. NR 11 TC 22 Z9 22 U1 1 U2 5 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 EI 1550-2376 J9 PHYS REV E JI Phys. Rev. E PD MAR PY 2005 VL 71 IS 3 AR 036612 DI 10.1103/PhysRevE.71.036612 PN 2 PG 12 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 922EC UT WOS:000228818200134 PM 15903610 ER PT J AU Weon, JI Creasy, TS Sue, HJ Hsieh, AJ AF Weon, JI Creasy, TS Sue, HJ Hsieh, AJ TI Mechanical behavior of polymethylmethacrylate with molecules oriented via simple shear SO POLYMER ENGINEERING AND SCIENCE LA English DT Article ID CHANNEL ANGULAR EXTRUSION; PLASTIC-DEFORMATION BEHAVIOR; POLYCARBONATE PLATE; POLY(ETHYLENE-TEREPHTHALATE) AB Equal-channel angular-extrusion (ECAE) may greatly alter polymer properties because it creates anisotropy in the microstructure. Tensile, fracture toughness, flexure, and ballistic impact tests were performed to quantify ECAE effects on polymethylmethacrylate (PMMA). Young's modulus increased by 5% for one process condition, while strength and elongation to failure remained the same or decreased. Fracture toughness improved by 178% under a one-pass condition. Ballistic impact resistance changes after molecular orientation by ECAE; the failure mode is along the weak planes formed by the first process. The process that subjects the specimen to a second extrusion with 180 degrees rotation produces more isotropic and ductile ballistic impact properties. (c) 2005 Society of Plastics Engineers. C1 Texas A&M Univ, Dept Mech Engn, Polymer Technol Ctr, College Stn, TX 77843 USA. USA, Res Lab, Polymer Res Branch, AMSRL,WM,MA,Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Creasy, TS (reprint author), Texas A&M Univ, Dept Mech Engn, Polymer Technol Ctr, College Stn, TX 77843 USA. EM Tereasy@mengr.tamu.edu RI Sue, HJ/A-4051-2008 OI Sue, HJ/0000-0002-3898-4469 NR 20 TC 30 Z9 31 U1 1 U2 10 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0032-3888 J9 POLYM ENG SCI JI Polym. Eng. Sci. PD MAR PY 2005 VL 45 IS 3 BP 314 EP 324 DI 10.1002/pen.20269 PG 11 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA 907IF UT WOS:000227709400008 ER PT J AU Ding, XZ Bhattacharjee, A Nikolich, MP Paulsen, IT Myers, G Seshadri, R Hoover, DL AF Ding, XZ Bhattacharjee, A Nikolich, MP Paulsen, IT Myers, G Seshadri, R Hoover, DL TI Cloning, expression, and purification of Brucella suis outer membrane proteins SO PROTEIN EXPRESSION AND PURIFICATION LA English DT Article DE Brucella suis; recombinant membrane proteins; antiserum; IFN-gamma; vaccine; diagnostic reagents ID NUCLEOTIDE-SEQUENCE; GENE; MELITENSIS; ABORTUS; PROTECTION; ANTIGEN; PLANT AB Brucella, an aerobic, nonsporeforming, nonmotile Gram-negative coccobacillus. is a NIH/CDC category B bioterror threat agent that causes incapacitating human illness. Medical defense against the bioterror threat posed by Brucella would be strengthened by development of a human vaccine and improved diagnostic tests. Central to advancement of these goals is discovery of bacterial constituents that are immunogenic or antigenic for humans. Outer membrane proteins (OMPs) are particularly attractive for this put-pose. In this study, we cloned, expressed, and purified seven predicted OMPs of Brucella suis. The recombinant proteins were fused with 6-His and V5 epitope tags at their C termini to facilitate detection and purification. The B. suis surface genes were PCR synthesized based on their ORF sequences and directly cloned into an entry vector. The recombinant entry constructs were propagated in TOP 10 cells, recombined into a destination vector, pET-DEST42, then transformed into Escherichia coli BL21 cells for IPTG-induced protein expression. The expressed recombinant proteins were confirmed with Western blot analysis using anti-6-His antibody conjugated with alkaline phosphatase. These B. suis OMPs were captured and purified using a HisGrab plate. The purified recombinant proteins were examined for their binding activity with antiserum. Serum derived front a rabbit immunized intramuscularly with dialyzed cell lysate of Brucella rough mutant WRR51. The OMPs were screened using the rabbit antiserum and purified IgG. The results suggested that recombinant B. suis OMPs were successfully cloned, expressed and purified. Some of the expressed OMPs showed high binding activity with immunized rabbit antiserum. (c) 2005 Elsevier Inc. All rights reserved. C1 Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div CD&I, Dept Bacterial Dis, Washington, DC 20307 USA. RP Bhattacharjee, A (reprint author), Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div CD&I, Dept Bacterial Dis, Washington, DC 20307 USA. EM tom.ding@na.amedd.army.mil RI Nikolich, Mikeljon/B-2868-2011; Paulsen, Ian/K-3832-2012; Myers, Garry/E-7708-2011 OI Paulsen, Ian/0000-0001-9015-9418; Myers, Garry/0000-0002-4756-4810 NR 20 TC 7 Z9 7 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1046-5928 J9 PROTEIN EXPRES PURIF JI Protein Expr. Purif. PD MAR PY 2005 VL 40 IS 1 BP 134 EP 141 DI 10.1016/j.pep.2004.12.017 PG 8 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 904SB UT WOS:000227516900015 PM 15721781 ER PT J AU Goodin, JL Raab, RW McKown, RL Coffman, GL Powell, BS Enama, JT Ligon, JA Andrews, GP AF Goodin, JL Raab, RW McKown, RL Coffman, GL Powell, BS Enama, JT Ligon, JA Andrews, GP TI Yersinia pestis outer membrane type III secretion protein YscC: expression, purification, characterization, and induction of specific antiserum SO PROTEIN EXPRESSION AND PURIFICATION LA English DT Article DE Yersinia pestis; yscC type III secretion; intein; His-tag ID ESCHERICHIA-COLI; PNEUMONIC PLAGUE; PLASMID PFRA; V-ANTIGEN; ENTEROCOLITICA; VIRULENCE; MUTAGENESIS; EFFICACY; SYSTEMS; OPERON AB The type III secretion system (YscC) protein of Yersinia Pestis plays an essential role in the translocation of Yersinia outer proteins (Yops) into eukaryotic target cells through a type III secretion mechanism. To assess the immunogenicity and potential protective efficacy of YscC against lethal plague challenge, we cloned, overexpressed, and purified YscC using two different bacterial expression and purification systems. The resulting expression plasmids for YscC, pETBlue-2-YscC and pTYB11-YscC, were regulated by robust T7 promoters that were induced with isopropyl-beta-D-thiogalactopyranoside. The intein-fusion pTYB11-YscC system and the six-histidine-tagging pETBlue-2-YscC system were both successful for producing and purifying YscC. The intein-mediated purification system produced about 1 mg of soluble YscC per liter of bacterial culture while the YscC-HiS(6)-tag method resulted in 16 mg of insoluble YscC per liter of bacterial culture. Protein identity for purified YscC-His(6) was confirmed by ion trap mass spectrometry. Antisera were produced against both YscC and YscC-His(6). The specific immune response generated in YscC-vaccinated mice was relative to the particular purified protein, YscC or YscC-His(6), which was used for vaccination as determined by Western blot analysis and ELISA. Regardless of the purification method, either form of the YscC protein failed to elicit a protective immune response against lethal plague challenge with either F1 capsule forming Y. pestis CO92 or the isogenic F1(-) Y. pestis C12. Published by Elsevier Inc. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. James Madison Univ, Dept Integrated Sci & Technol, Harrisonburg, VA 22807 USA. Univ Wyoming, Dept Vet Sci, Laramie, WY 82070 USA. RP Goodin, JL (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. EM Jeremy.Goodin@det.amedd.army.mil NR 31 TC 10 Z9 11 U1 1 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1046-5928 J9 PROTEIN EXPRES PURIF JI Protein Expr. Purif. PD MAR PY 2005 VL 40 IS 1 BP 152 EP 163 DI 10.1016/j.pep.2004.11.001 PG 12 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 904SB UT WOS:000227516900017 PM 15721783 ER PT J AU Banks, KP AF Banks, KP TI The target sign: Extremity SO RADIOLOGY LA English DT Article ID NERVE SHEATH TUMORS; LARGE REFERRAL POPULATION; SOFT-TISSUE TUMORS; DIAGNOSES; LOCATION; BENIGN; SEX; AGE C1 Brooke Army Med Ctr, MCHE DR, Dept Radiol, Ft Sam Houston, TX 78234 USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, MCHE DR, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM kevin.banks@cen.amedd.army.mil NR 13 TC 24 Z9 25 U1 0 U2 1 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0033-8419 J9 RADIOLOGY JI Radiology PD MAR PY 2005 VL 234 IS 3 BP 899 EP 900 DI 10.1148/radiol.2343030946 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 899LM UT WOS:000227145900031 PM 15734940 ER PT J AU Cohen, SP Larkin, TM Barna, SA Palmer, WE Hecht, AC Stojanovic, MP AF Cohen, SP Larkin, TM Barna, SA Palmer, WE Hecht, AC Stojanovic, MP TI Lumbar discography: A comprehensive review of outcome studies, diagnostic accuracy, and principles SO REGIONAL ANESTHESIA AND PAIN MEDICINE LA English DT Review DE degenerative disc disease; discogenic pain; discography; internal disc disruption; intervertebral disc; lumbar spine ID LOW-BACK-PAIN; ARTIFICIAL DISC REPLACEMENT; INTRADISCAL ELECTROTHERMAL TREATMENT; PREVIOUSLY ASYMPTOMATIC SUBJECTS; HIGH-INTENSITY ZONE; MINIMUM FOLLOW-UP; INTERVERTEBRAL DISCS; NUCLEUS PULPOSUS; PROVOCATIVE DISCOGRAPHY; PROPHYLACTIC ANTIBIOTICS AB Background and Objectives: Since its advent more than 50 years ago, the use of discography has been mired in controversy. The purpose of this review is to provide a clinical overview of lumbar discography and discogenic back pain, with special emphasis on determining the accuracy of discography and whether or not the procedure improves outcomes for surgery. Methods: Material for this review was obtained from a MEDLINE search conducted from 1951 thru September 2004, bibliographic references, book chapters, and conference proceedings. Results: Based on a large number of comparative studies, plain discography is less accurate than magnetic resonance imaging in diagnosing lumbar herniated nucleus pulposus and comparable or slightly more sensitive in detecting degenerative disc disease. For disc degeneration, CT discography remains the gold standard for diagnosis. There are very few studies comparing surgical outcomes between patients who have undergone preoperative provocative discography and those who have not. What little evidence exists is conflicting. Before disc replacement surgery, approximately half the studies have used preoperative discography. A comparison of outcomes did not reveal any significant difference between the 2 groups but none of the studies was controlled, and they used different outcome measures, follow-up periods, and surgical techniques. Because all intradiscal electrothermal therapy (IDET) studies have used discography before surgery, no conclusions can be drawn regarding its effects on outcome. Conclusions: Although discography, especially combined with CT scanning, may be more accurate than other radiologic studies in detecting degenerative disc disease, its ability to improve surgical outcomes has yet to be proven. In the United States and Europe, there are inconsistencies in the use of lumbar discography such that it is routinely used before IDET, yet only occasionally used before spinal fusion. C1 Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Pain Management Ctr, Baltimore, MD 21205 USA. Walter Reed Army Med Ctr, Pain Management Ctr, Washington, DC 20307 USA. Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Anesthesia & Crit Care,MGH Pain Ctr, Boston, MA 02115 USA. Walter Reed Army Med Ctr, Dept Anesthesiol, Washington, DC 20307 USA. Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02115 USA. Mt Sinai Sch Med, Dept Orthoped Surg, New York, NY USA. RP Cohen, SP (reprint author), Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Pain Management Ctr, 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu NR 150 TC 49 Z9 52 U1 0 U2 8 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 1098-7339 J9 REGION ANESTH PAIN M JI Region. Anesth. Pain Med. PD MAR-APR PY 2005 VL 30 IS 2 BP 163 EP 183 DI 10.1016/j.rapm.2004.10.006 PG 21 WC Anesthesiology SC Anesthesiology GA 908OJ UT WOS:000227796100008 PM 15765459 ER PT J AU Buckenmaier, CC McKnight, GM Winkley, JV Bleckner, LL Shannon, C Klein, SM Lyons, RC Chiles, JH AF Buckenmaier, CC McKnight, GM Winkley, JV Bleckner, LL Shannon, C Klein, SM Lyons, RC Chiles, JH TI Continuous peripheral nerve block for battlefield anesthesia and evacuation SO REGIONAL ANESTHESIA AND PAIN MEDICINE LA English DT Article; Proceedings Paper CT 29th Annual Spring Meeting of the American-Society-of-Regional-Anesthesia-and-Pain-Medicine CY MAR 11-14, 2004 CL Orlando, FL SP Amer Soc Reg Anesthesia & Pain Med DE regional anesthesia; battlefield anesthesia; military anesthesia; continuous peripheral nerve block ID SURGERY; ANALGESIA; CATHETER; HOME AB Peripheral nerve and continuous peripheral nerve block (CPNB) have the potential to be valuable techniques in combat anesthesia. We describe the first successful application of CPNB in the pain management and surgical management of a combat casualty as he was evacuated from the Iraqi battlefield to the United States. C1 Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Walter Reed Hlth Care Syst, Washington, DC 20307 USA. Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA. 21st Combat Support Hosp, Clin Serv, Vth Corps, Balad, Iraq. Walter Reed Army Med Ctr, Anesthesia & Operat Serv, Walter Reed Hlth Care Syst, Washington, DC 20307 USA. RP Buckenmaier, CC (reprint author), Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Walter Reed Hlth Care Syst, Washington, DC 20307 USA. EM chester.buckenmaier@na.amedd.army NR 14 TC 32 Z9 34 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 1098-7339 J9 REGION ANESTH PAIN M JI Region. Anesth. Pain Med. PD MAR-APR PY 2005 VL 30 IS 2 BP 202 EP 205 DI 10.1016/j.rapm.2004.10.005 PG 4 WC Anesthesiology SC Anesthesiology GA 908OJ UT WOS:000227796100012 PM 15765463 ER PT J AU Rogers, CJ AF Rogers, CJ TI The chivalric ethos and the development of military professionalism. SO SIXTEENTH CENTURY JOURNAL LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Rogers, CJ (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SIXTEENTH CENTURY JOURNAL PUBL PI KIRKSVILLE PA MC111-L, TRUMAN STATE UNIV, 100 E NORMAL ST, KIRKSVILLE, MO 63501-4211 USA SN 0361-0160 J9 SIXTEENTH CENT J JI Sixt. Century J. PD SPR PY 2005 VL 36 IS 1 BP 184 EP 185 PG 2 WC History SC History GA 917OM UT WOS:000228472100030 ER PT J AU Frizzi, JD Ray, PD Raff, JB AF Frizzi, JD Ray, PD Raff, JB TI Enteral nutrition by a forward surgical team in Afghanistan SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE enteral feeding; forward surgical team; injury; military facility AB Objectives: The modern practice of trauma surgery is a global physiologic approach to caring for the injured patient. Included in that approach is consideration of the traumatized patient's nutritional needs and implementing early enteral feeding. This is routine practice in the United States but logistically impractical when using commercial enteral feeding formulas in the austere environment of a Forward Operating Base in Afghanistan. Methods: At a Forward Operating Base in southern Afghanistan, injured patients who were not expected to be taking a regular diet by 72 hours after injury are started on early enteral feedings. This is through nasogastric, gastrostomy, or jejunostomy tube, using formulas of pureed food available in the theater from local sources and supplemented with ingredients from US Army Meals-Ready-to-Eat. Preparation, nutritional calculation, and delivery are discussed. Results: The injured soldiers and Afghan nationals tolerated early enteral feedings with no complications encountered related to the feeding portal, infusion, or ingredients. Conclusions: Early enteral feeding of traumatized patients in the far forward environment of southeastern Afghanistan is practical with the use of ingredients found locally in-theater. C1 USA, Dwight D Eisenhower Med Ctr, Gen Surg Serv, Ft Gordon, GA 30905 USA. RP Frizzi, JD (reprint author), USA, Dwight D Eisenhower Med Ctr, Gen Surg Serv, Ft Gordon, GA 30905 USA. EM james.frizzi@se.amedd.army.mil NR 6 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2005 VL 98 IS 3 BP 273 EP 278 DI 10.1097/01.SMJ.0000154310.53647.ED PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 908HZ UT WOS:000227779400004 PM 15813153 ER PT J AU Wilson, RL Ritter, JB Roy, MJ AF Wilson, RL Ritter, JB Roy, MJ TI March madness-associated deep vein thrombosis SO SOUTHERN MEDICAL JOURNAL LA English DT Letter C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Wilson, RL (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2005 VL 98 IS 3 BP 396 EP 396 DI 10.1097/01.SMJ.0000154320.92207.40 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 908HZ UT WOS:000227779400024 PM 15813172 ER PT J AU Schutz, HG Cardello, AV Winterhalter, C AF Schutz, HG Cardello, AV Winterhalter, C TI Perceptions of fiber and fabric uses and the factors contributing to military clothing comfort and satisfaction SO TEXTILE RESEARCH JOURNAL LA English DT Article ID CONJOINT-ANALYSIS AB Attitudes of military consumers toward commercial and military fibers, fabrics, and military battle dress uniforms (BDU) are assessed using item-by-use appropriateness scaling and conjoint analysis. The item-by use appropriateness ratings uncover strong stereotypes about the tactile and functional characteristics of the fibers/fabrics and their appropriateness for use in specific situations and/or environmental circumstances. Both the fibers and fabrics and their uses and characteristics are reduced to a minimum number of factors using principle components analyses. A multiple regression model shows that the discomfort of the fibers/fabrics can be predicted from a combination of "tactile" and "functional" characteristics. Results of the conjoint analyses reveal that the thermal properties of the hot weather BDu and the "abrasiveness" of the temperate BDu are the most important factors contributing to their (dis)comfort. Although fit is the most important factor contributing to overall consumer satisfaction with the BDU, tactile and appearance factors are equivalently important to such functional factors as protection and durability. The data, methodologies, and approach can be used to better understand consumer attitudes toward both military and commercial fibers, fabrics, and utility uniforms. C1 USA, Natrick Soldier Ctr, Sci & Technol Directorate, Natick, MA 01760 USA. Univ Calif Davis, Dept Text & Clothing, Davis, CA 95616 USA. USA, Natrick Soldier Ctr, Individual Protect Directorate, Natick, MA 01760 USA. RP Cardello, AV (reprint author), USA, Natrick Soldier Ctr, Sci & Technol Directorate, Natick, MA 01760 USA. EM armand.cardello@natick.army.mil NR 36 TC 30 Z9 30 U1 0 U2 6 PU TEXTILE RESEARCH INST PI PRINCETON PA PO BOX 625, PRINCETON, NJ 08540 USA SN 0040-5175 J9 TEXT RES J JI Text. Res. J. PD MAR PY 2005 VL 75 IS 3 BP 223 EP 232 DI 10.1177/004051750507500307 PG 10 WC Materials Science, Textiles SC Materials Science GA 912QB UT WOS:000228093200007 ER PT J AU Sheridan, RE Smith, TJ Adler, M AF Sheridan, RE Smith, TJ Adler, M TI Primary cell culture for evaluation of botulinum neurotoxin antagonists SO TOXICON LA English DT Article DE botulinum neurotoxin; mouse; antitoxin; spinal cord; diaphragm; muscle tension; transmitter release ID MOUSE SPINAL-CORD; TETANUS TOXIN; NEURONS; INHIBITOR; SNAP-25; RELEASE; PROTEIN; INTACT AB The actions of botulinum neurotoxin (BoNT) were studied on evoked release of the neurotransmitter glycine in primary mouse spinal cord cells. (3)[H]-glycine was taken up by cells in physiological solution and released by depolarization with 56 mM K+ in the presence of 2 mM Ca2+. Release of (3)[H]-glycine was found to be inhibited by BoNT serotypes A, B and E with similar potency ratios to those observed in the acutely isolated mouse diaphragm muscle. When spinal cord cultures were exposed to BoNT/A for 24 h, inhibition of (3)[H]-glycine release was detected at toxin concentrations as low as 10(-14) M, and complete inhibition was observed at concentration greater than or equal to10(-12) M. Preincubation of BoNT/A with polyclonal equine antiserum led to antagonism of toxin-induced inhibition of (3)[H]-glycine release in spinal cord cells and to protection of mice from the lethal effects of BoNT/A. It is concluded that spinal cord neurons are a useful model for studying botulinum intoxication and for evaluating BoNT antagonists. Published by Elsevier Ltd. C1 USA, Med Res Inst Chem Def, Div Pharmacol, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA. USA, Med Res Inst Infect Dis, Div Toxinol, Ft Detrick, MD 21702 USA. RP Adler, M (reprint author), USA, Med Res Inst Chem Def, Div Pharmacol, Neurotoxicol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM michael.adler@amedd.army.mil NR 25 TC 16 Z9 19 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD MAR 1 PY 2005 VL 45 IS 3 BP 377 EP 382 DI 10.1016/j.toxicon.2004.11.009 PG 6 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 897UB UT WOS:000227029800016 PM 15683877 ER PT J AU Hanley, KA Goddard, LB Gilmore, LE Scott, TW Speicher, J Murphy, BR Pletnev, AG AF Hanley, KA Goddard, LB Gilmore, LE Scott, TW Speicher, J Murphy, BR Pletnev, AG TI Infectivity of west Nile/Dengue chimeric viruses for West Nile and dengue mosquito vectors SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Dengue virus; West Nile virus; mosquito ID SIZED RNA SEGMENT; AEDES-AEGYPTI; VACCINE CANDIDATE; MOLECULAR-BASIS; RHESUS-MONKEYS; OS INFECTION; TYPE-4; COMPETENCE; LIVE; SUSCEPTIBILITY AB West Nile virus (WN), an agent of significant human and veterinary disease, is endemic in the Old World and rapidly spreading throughout the Americas. Vaccines are needed to halt the geographic expansion of this virus and prevent disease where it is established. However, to preclude introduction of a vaccine virus into the environment, a live attenuated WN vaccine should have low potential for transmission by mosquitoes. A chimeric WN vaccine candidate was previously generated by replacing the membrane and envelope structural protein genes of recombinant dengue type 4 virus (rDEN4) with those of WN; a derivative of this virus, WN/DEN4-3'Delta 30, contains a 30-nucleotide deletion in the 3' untranslated region. To assess the potential for transmission by mosquitoes of these vaccine candidates, the ability of each chimeric virus to infect the mosquito midgut, disseminate to the head, and pass into the saliva was compared to that of their wild-type parental WN and DEN4 viruses in three vector species. The WN/DEN4 chimeric viruses were significantly attenuated in both Culex tarsalis, a vector able to transmit WN but not dengue, and in Ae. aegypti, a vector able to transmit dengue but not WN. However, the chimeric viruses were as infectious as either wild-type virus for Ae. albopictus, a vector able to transmit both dengue and WN. These results indicate that chimerization caused a contraction in vector host range rather than universal attenuation for mosquitoes per se. This restriction in potential vectors renders it less likely that WN/DEN4 and WN/DEN4-3'Delta 30 would be transmitted from vaccinees to mosquitoes. C1 New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA. NIAID, Infect Dis Lab, NIH, Bethesda, MD USA. Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. RP Hanley, KA (reprint author), New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA. EM khanley@nmsu.edu NR 38 TC 24 Z9 24 U1 1 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD SPR PY 2005 VL 5 IS 1 BP 1 EP 10 DI 10.1089/vbz.2005.5.1 PG 10 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 916KY UT WOS:000228385000001 PM 15815144 ER PT J AU Jorgeson, J Julien, P AF Jorgeson, J Julien, P TI Peak flow forecasting with radar precipitation and the distruibuted model CASC2D SO WATER INTERNATIONAL LA English DT Article DE distributed modeling; flow forecasting; lead time; radar precipitation; weather radar; watershed model ID SURFACE RUNOFF; RAINFALL; PREDICTION AB The processing speed of computers and availability of spatial hydrologic data make distributed watershed models a viable approach for many applications, including peak flow forecasting. This study demonstrates the feasibility of using radar precipitation data with a distributed watershed model to obtain increased lead-time for peak flow forecasting. The CASC2D watershed model is applied to the Hassyampa River watershed in central Arizona using radar-based rainfall estimatesfrom the National Weather Service WSR-88D weather radar An application of radar rainfall data as input to the CASC2D model is then presented by which precipitation forecasts are generated by extrapolation of precipitation patterns from radar images. The calibrated model is run for two rainfall events: with and without linear precipitation forecasts. Results of this study confirm that the precipitation forecasts based on extrapolation of rainfall patterns from radar can produce increases in the forecast lead-time. For the two events presented, the forecast lead-time was increased by four to five hours, which can be significant when issuing flood warnings. C1 USA, Corps Engineers, Ctr Res & Dev, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. Colorado State Univ, Ft Collins, CO 80523 USA. RP Jorgeson, J (reprint author), USA, Corps Engineers, Ctr Res & Dev, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. NR 22 TC 4 Z9 4 U1 0 U2 4 PU INT WATER RESOURCES ASSOC PI CARBONDALE PA SOUTHERN ILLINOIS UNIV, 4535 FANER HALL, MC 4516, CARBONDALE, IL 62901-4516 USA SN 0250-8060 J9 WATER INT JI Water Int. PD MAR PY 2005 VL 30 IS 1 BP 40 EP 49 PG 10 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 002NR UT WOS:000234618700006 ER PT J AU D'Angelo, EM Karathanasis, AD Sparks, EJ Ritchey, SA Wehr-McChesney, SA AF D'Angelo, EM Karathanasis, AD Sparks, EJ Ritchey, SA Wehr-McChesney, SA TI Soil carbon and microbial communities at mitigated and late successional bottomland forest wetlands SO WETLANDS LA English DT Article DE wetland succession; carbon quality; phospholipid fatty acids; microbial respiration; soil water-holding capacity; wetland functions ID FATTY-ACID PATTERNS; MARINE-SEDIMENTS; PROFILES; NITROGEN; MINERALIZATION; BACTERIA; ISO AB The practice of wetland mitigation has come into question during the past decade because the relative capacity of the mitigated wetlands to perform normal wetland functions is mostly unknown. In this study, we wanted to determine whether soil microbial communities were significantly different in early successional mitigated wetlands (< 10 years) (ES) compared to late successional bottomland hardwood forest wetlands (LS) due to differences in soil properties, such as carbon quality and storage and water-holding capacity. Carbon storage in litter and soil was 1.5 times greater in LS wetlands than ES wetlands. Soil water-holding capacity was significantly greater in LS wetlands and was related to soil organic C content (r(2)=0.87, p-value=0.0007). Gravimetric water content was a moderately strong predictor of microbial respiration (r(2)=0.55-0.61, p-value=0.001-0.0004) and microbial biomass (r(2)=0.70, p-value=0.0019). Anaerobic microbial groups were enriched in soils from LS wetlands in both the dry and wet seasons, which suggested that LS soils were wetter for longer periods of the year than ES soils. The capacity of these wetlands to support anaerobic microbial processes depends on soil water retention characteristics, which were dictated by organic matter content. As an integrator of microbial growth conditions in soils, determination of microbial community composition by phospholipid fatty acid (PLFA) analysis may be an important new tool for monitoring successional development of compensatory mitigation wetlands. C1 Univ Kentucky, Soil & Water Biogeochem Lab, Lexington, KY 40546 USA. Univ Kentucky, Dept Plant & Soil Sci, Lexington, KY 40546 USA. USA, Eastern Kentucky Regulatory Off, Sassafras, KY 41759 USA. RP D'Angelo, EM (reprint author), Univ Kentucky, Soil & Water Biogeochem Lab, N 122 Agr Sci Bldg, Lexington, KY 40546 USA. EM edangelo@uky.edu NR 39 TC 24 Z9 24 U1 0 U2 13 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 J9 WETLANDS JI Wetlands PD MAR PY 2005 VL 25 IS 1 BP 162 EP 175 DI 10.1672/0277-5212(2005)025[0162:SCAMCA]2.0.CO;2 PG 14 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 918KZ UT WOS:000228542000015 ER PT J AU Best, EPH Kvesitadze, G Khatisashvili, G Sadunishvili, T AF Best, EPH Kvesitadze, G Khatisashvili, G Sadunishvili, T TI Plant processes important for the transformation and degradation of explosives contaminants SO ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES LA English DT Article; Proceedings Paper CT International Workshop on Phytoremediation - Environmental and Molecular Biological Aspects CY SEP 09-12, 2004 CL Matrahaza, HUNGARY SP Hungarian Acad Sci, OECD, Minist Environm Hungary DE explosives; transformation; phytoremediation ID ARMY AMMUNITION PLANT; HYBRID POPLAR TREES; ENVIRONMENTAL BEHAVIOR; TNT; 2,4,6-TRINITROTOLUENE; FATE; RDX; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; BIOTRANSFORMATION; GROUNDWATER AB Environmental contamination by explosives is a worldwide problem. Of the 20 energetic compounds, 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) are the most powerful and commonly used. Nitroamines are toxic and considered as possible carcinogens. The toxicity and persistence of nitroamines requires that their fate in the environment be understood and that contaminated soil and groundwater be remediated. This study, written as a minireview, provides further insights for plant processes important for the transformation and degradation of explosives. Plants metabolize TNT and the distribution of the transformation products, conjugates, and bound residues appears to be consistent with the green liver model concept. Metabolism of TNT in plants occurs by reduction as well as by oxidation. Reduction probably plays an important role in the tolerance of plants towards TNT, and, therefore a high nitroreductase capacity may serve as a biochemical criterion for the selection of plant species to remediate TNT. Because the activities and the inducibilities of the oxidative enzymes are far lower than of nitroreductase, reducing processes may predominate. However, oxidation may initiate the route to conjugation and sequestration leading ultimately to detoxification of TNT, and, therefore, particularly the oxidative pathway deserves more study. It is possible that plants metabolize RDX also according to the green liver concept. In the case of plant metabolism of HMX, a conclusion regarding compliance with the green liver concept was not reached due to the limited number of available data. C1 USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. Georgian Acad Sci, Durmishidze Inst Plant Biochem, GE-0159 Tbilisi, Rep of Georgia. RP Best, EPH (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM beste@wes.army.mil NR 47 TC 14 Z9 15 U1 0 U2 4 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0939-5075 EI 1865-7125 J9 Z NATURFORSCH C JI Z.Naturforsch.(C) PD MAR-APR PY 2005 VL 60 IS 3-4 BP 340 EP 348 PG 9 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 940NX UT WOS:000230152300028 PM 15948604 ER PT J AU Stein, K Tezduyar, TE Sathe, S Benney, R Charles, R AF Stein, K Tezduyar, TE Sathe, S Benney, R Charles, R TI Fluid-structure interaction modelling of parachute soft-landing dynamics SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS LA English DT Article; Proceedings Paper CT 5th World Congress on Computational Mechanics CY JUL 07-12, 2002 CL Vienna, AUSTRIA DE flow simulation; parachute aerodynamics; soft landing; fluid-structure interactions ID FINITE-ELEMENT METHODS; FLOW PROBLEMS; FORMULATIONS; COMPUTATION; SIMULATION; INFLATION AB Soft landing of a payload with the aid of a retraction device is an important aspect in cargo parachute operations. Accurate simulation of this class of parachute operations with a computer model that takes into account the fluid-structure interactions involved would complement drop tests and support the design of cargo parachute systems. We describe the computational methods developed for this purpose, demonstrate how the computational model works in investigation of different soft-landing conditions, and show a good correlation between the data from our simulations and drop tests. Copyright (C) 2004 John Wiley Sons, Ltd. C1 Bethel Univ, Dept Phys, St Paul, MN 55112 USA. Rice Univ, Houston, TX 77005 USA. USA, Natl Soldier Ctr, Natick, MA 01760 USA. RP Stein, K (reprint author), Bethel Univ, Dept Phys, St Paul, MN 55112 USA. EM k-stein@bethel.edu RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 23 TC 5 Z9 5 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-2091 J9 INT J NUMER METH FL JI Int. J. Numer. Methods Fluids PD FEB 28 PY 2005 VL 47 IS 6-7 BP 619 EP 631 DI 10.1002/fld.835 PG 13 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas SC Computer Science; Mathematics; Mechanics; Physics GA 901CE UT WOS:000227259800011 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of cyanogen isocyanate SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; cyanogen isocyanate ID MICROWAVE-SPECTRUM; NCNCO; MOLECULES; ISOMERS; SPECTROSCOPY; OXIDE AB The vibrational frequencies and corresponding normal mode assignments of cyanogen isocyanate (NCNCO) are examined theoretically using the GAUSSIAN 98 set of quantum chemistry codes. All normal-modes were. successfully assigned to one of seven types of motion predicted by a group theoretical analysis (C equivalent to O stretch, C-N stretch, C = N stretch, C equivalent to N stretch, N = C = O bend, N equivalent to C-N bend, and N-C = N bend). Theoretical infrared and Raman intensities are reported. The molecular orbitals and bonding of cyanogen isocyanate are examined. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSRD ECB RT DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD ECB RT DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 29 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD FEB 28 PY 2005 VL 715 IS 1-3 BP 1 EP 5 DI 10.1016/j.theochem.2004.09.040 PG 5 WC Chemistry, Physical SC Chemistry GA 905SN UT WOS:000227590100001 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of norbornadiene SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; norbornadiene; norborna-2,5-diene; bicyclo[2.2.1]hepta-2,5-diene ID MICROWAVE FOURIER-TRANSFORM; GAS ELECTRON DIFFRACTION; MOLECULAR-STRUCTURE; OLEFIN COMPLEXES; PI-COMPLEXES; SPECTROSCOPY; CARBONYL; SPECTRA; REARRANGEMENTS; CYCLOADDITION AB The vibrational frequencies and corresponding normal mode assignments of norbornadiene are examined theoretically using the GAUSSIAN98 set of quantum chemistry codes. All normal modes were successfully assigned to one five types of motion predicted by a group theoretical Analysis (C=C stretch, C-C stretch, C-H stretch, C-H bend, and C-C-C bend) utilizing the C-2v symmetry of the molecule. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSRD ECB RT DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD ECB RT DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 62 TC 3 Z9 3 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD FEB 28 PY 2005 VL 715 IS 1-3 BP 7 EP 13 DI 10.1016/j.theochem.2004.09.056 PG 7 WC Chemistry, Physical SC Chemistry GA 905SN UT WOS:000227590100002 ER PT J AU Simpson, WR Alvarez-Aviles, L Douglas, TA Sturm, M Domine, F AF Simpson, WR Alvarez-Aviles, L Douglas, TA Sturm, M Domine, F TI Halogens in the coastal snow pack near Barrow, Alaska: Evidence for active bromine air-snow chemistry during springtime SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID SURFACE OZONE DEPLETION; POLAR SUNRISE; CHEMICAL-COMPOSITION; FROST FLOWERS; SEA-SALT; AEROSOL; ICE; DESTRUCTION; MERCURY; HOBR AB We measured halide concentrations of snow and frost flowers in the vicinity of Barrow, Alaska. We find that the ratio of bromide to sodium in frost flowers is slightly enhanced ( approximate to 10%) as compared to sea water. In contrast, the ratio of bromide to sodium in some snow samples is more than an order of magnitude enhanced, and in other samples is more than an order of magnitude depleted. We interpret the bromide depleted snow as having been processed by heterogeneous chemistry and providing reactive halogen compounds to the atmosphere. The eventual end product of reactive bromine chemistry is HBr that is then deposited over a wide region, enhancing bromide in inland snow samples. Although frost flowers or open leads are likely to be the original source of halides that become reactive halogen gases, we find that the bromide release often occurs subsequent to production of aerosol from marine sources. Citation: Simpson, W. R., L. Alvarez- Aviles, T. A. Douglas, M. Sturm, and F. Domine ( 2005), Halogens in the coastal snow pack near Barrow, Alaska: Evidence for active bromine air- snow chemistry during springtime. C1 Univ Alaska, Inst Geophys, Fairbanks, AK 99775 USA. Univ Alaska, Dept Chem & Biochem, Fairbanks, AK 99775 USA. USA, Cold Reg Res & Engn Lab, Ft Wainwright, OR 97031 USA. CNRS, Lab Glaciol & Geophys Environm, F-38402 St Martin Dheres, France. RP Simpson, WR (reprint author), Univ Alaska, Inst Geophys, Fairbanks, AK 99775 USA. EM ffwrs@uaf.edu RI Domine, Florent/E-8699-2011; Simpson, William/I-2859-2014 OI Simpson, William/0000-0002-8596-7290 NR 23 TC 56 Z9 57 U1 48 U2 71 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD FEB 26 PY 2005 VL 32 IS 4 AR L04811 DI 10.1029/2004GL021748 PG 4 WC Geosciences, Multidisciplinary SC Geology GA 904VG UT WOS:000227525600002 ER PT J AU Ciezak, JA Trevino, SF AF Ciezak, JA Trevino, SF TI The inelastic neutron scattering spectra of alpha-3-amino-5-nitro-1,2,4-2H-triazole: Experiment and DFT calculations SO CHEMICAL PHYSICS LETTERS LA English DT Article ID HOT-SPOT FORMATION; POLYATOMIC-MOLECULES; AB-INITIO; SOLIDS AB The inelastic neutron scattering (INS) spectrum of alpha-3-amino-5-nitro-1,2,4-triazole is presented through 1200 cm(-1). A comparison of the INS spectrum with an isolated molecule B3LYP/6-311G** calculation reveals generally good frequency and intensity agreement with two notable differences in intensity. Periodic density functional theory (DFT) calculations are employed to determine whether the intermolecular hydrogen bonding is the origin of these differences between the B3LYP/6-311G** and INS spectrum. (C) 2005 Elsevier B.V. All rights reserved. C1 USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA. RP Ciezak, JA (reprint author), USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM jciezak@arl.army.mil NR 21 TC 22 Z9 23 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD FEB 25 PY 2005 VL 403 IS 4-6 BP 329 EP 333 DI 10.1016/j.cplett.2006.01.033 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 901PM UT WOS:000227294400019 ER PT J AU Douglas, TA Sturm, M Simpson, WR Brooks, S Lindberg, SE Perovich, DK AF Douglas, TA Sturm, M Simpson, WR Brooks, S Lindberg, SE Perovich, DK TI Elevated mercury measured in snow and frost flowers near Arctic sea ice leads SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID POLAR SUNRISE; TROPOSPHERIC CHEMISTRY; ATMOSPHERIC MERCURY; GASEOUS MERCURY; SURFACE; OZONE; DEPLETION; SPRINGTIME; GROWTH; AREA AB Elevated mercury concentrations have been reported in arctic coastal snow far from emission sources. The mercury is deposited during mercury depletion events (MDEs), a set of photochemical atmospheric reactions involving reactive halogens. The highest mercury concentrations are clustered near the coast, leading to speculation that sea ice or sea ice leads play a role in MDEs. The nature of this connection is not fully understood. We report mercury concentrations up to 820 ng/L in snow and frost flowers along sea ice leads near Barrow, Alaska. These concentrations are nine times higher than values from nearby coastal snow and are almost half of the mercury maximum contaminant level in United States drinking water. The high values were found only near leads that had convective plumes above open water suggesting that the same processes that produce a supersaturated environment for water vapor near sea ice leads may be instrumental in mercury deposition. C1 USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. Univ Alaska, Dept Chem, Fairbanks, AK 99701 USA. Univ Alaska, Inst Geophys, Fairbanks, AK 99701 USA. Natl Ocean & Atmospher Adm, Atmospher Turbulence & Diffus Div, Oak Ridge, TN USA. Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Douglas, TA (reprint author), USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. EM thomas.a.douglas@erdc.usace.army.mil RI Simpson, William/I-2859-2014 OI Simpson, William/0000-0002-8596-7290 NR 22 TC 46 Z9 48 U1 0 U2 9 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD FEB 25 PY 2005 VL 32 IS 4 AR L04502 DI 10.1029/2004GL022132 PG 4 WC Geosciences, Multidisciplinary SC Geology GA 904VE UT WOS:000227525400008 ER PT J AU Grujicic, M Cao, G Pandurangan, B Roy, WN AF Grujicic, M Cao, G Pandurangan, B Roy, WN TI Finite element analysis-based design of a fluid-flow control nano-valve SO MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY LA English DT Article DE single-walled carbon nano-tubes; nano-devices; nano-technology ID CARBON NANOTUBES; FORCE-FIELD; MECHANICS; COMPASS AB A finite element method-based procedure is developed for the design of molecularly functionalized nano-size devices. The procedure is aimed at the single-walled carbon nano-tubes (SWCNTs) used in the construction of such nano-devices and utilizes spatially varying nodal forces to represent electrostatic interactions between the charged groups of the functionalizing molecules. The procedure is next applied to the design of a fluid-flow control nano-valve. The results obtained suggest that the finite element-based procedure yields the results, which are very similar to their molecular modeling counterparts for small-size nano-valves, for which both types of analyses are feasible. The procedure is finally applied to optimize the design of a larger-size nano-valve, for which the molecular modeling approach is not practical. (C) 2004 Elsevier B.V. All rights reserved. C1 Clemson Univ, Dept Mech Engn, Program Mat Sci & Engn, Clemson, SC 29634 USA. USA, Res Lab, Proc & Properties Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Program Mat Sci & Engn, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu RI Cao, guoxin/A-9790-2012 OI Cao, guoxin/0000-0002-6598-2899 NR 10 TC 15 Z9 15 U1 0 U2 4 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5107 J9 MAT SCI ENG B-SOLID JI Mater. Sci. Eng. B-Solid State Mater. Adv. Technol. PD FEB 25 PY 2005 VL 117 IS 1 BP 53 EP 61 DI 10.1016/j.mseb.2004.10.020 PG 9 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA 899RW UT WOS:000227163500009 ER PT J AU Mohamadzadeh, M Olson, S Kalina, WV Ruthel, G Demmin, GL Warfield, KL Bavari, S Klaenhammer, TR AF Mohamadzadeh, M Olson, S Kalina, WV Ruthel, G Demmin, GL Warfield, KL Bavari, S Klaenhammer, TR TI Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID LACTIC-ACID BACTERIA; IMMUNE-SYSTEM; PROBIOTICS; MATURATION; RESPONSES; ANTIGEN; EXPRESSION; RHAMNOSUS; INDUCTION; CYTOKINES AB Professional antigen-presenting dendritic cells (DCs) are critical in regulating T cell immune responses at both systemic and mucosal sites. Many Lactobacillus species are normal members of the human gut microflora and most are regarded as safe when administered as probiotics. Because DCs can naturally or therapeutically encounter lactobacilli, we investigated the effects of several well defined strains, representing three species of Lactobacillus on human myeloid DCs (MDCs) and found that they modulated the phenotype and functions of human MDCs. Lactobacillus-ex posed MDCs up-regulated HLA-DR, CD83, CD40, CD80, and CD86 and secreted high levels of IL-12 and IL-18, but not IL-10. IL-12 was sustained in MDCs exposed to all three Lactobacillus species in the presence of LPS from Escherichia coli, whereas LPS-induced IL-10 was greatly inhibited. MDCs activated with lactobacilli clearly skewed CD4(+) and CID8(+) T cells to T helper 1 and Tc1 polarization, as evidenced by secretion of IFN-gamma, but not IL-4 or IL-13. These results emphasize a potentially important role for lactobacilli in modulating immunological functions of DCs and suggest that certain strains could be particularly advantageous as vaccine adjuvants, by promoting DCs to regulate T cell responses toward T helper 1 and Tc1 pathways. C1 NCI, Frederick, MD 21702 USA. Louisiana State Univ, Dept Microbiol, New Orleans, LA 70112 USA. Tulane Univ, Ctr Gene Therapy, New Orleans, LA 70112 USA. USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. N Carolina State Univ, Dept Food Sci, Raleigh, NC 27695 USA. RP Mohamadzadeh, M (reprint author), NCI, Frederick, MD 21702 USA. EM mzadeh@ncifcrf.gov FU NCRR NIH HHS [P51 RR000164, RR00164]; NIAID NIH HHS [AI 59590-01, R21 AI059590] NR 40 TC 264 Z9 282 U1 0 U2 10 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD FEB 22 PY 2005 VL 102 IS 8 BP 2880 EP 2885 DI 10.1073/pnas.0500098102 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 900RQ UT WOS:000227232400039 PM 15710900 ER PT J AU Cabalo, J Sausa, R AF Cabalo, J Sausa, R TI Trace detection of explosives with low vapor emissions by laser surface photofragmentation-fragment detection spectroscopy with an improved ionization probe SO APPLIED OPTICS LA English DT Article ID THERMAL-DECOMPOSITION; ENERGETIC MATERIALS; AB-INITIO; RDX; MECHANISM; THERMOLYSIS; PRESSURE; PRODUCTS; HMX AB Trace explosive residues are measured in real time by surface laser photafragmentation-fragment detection (SPF-FD) spectroscopy at ambient conditions. A 248-nm laser photofragments the target residue on a substrate, and a 226-nm laser ionizes the resulting NO fragment by resonance-enhanced multiphoton ionization by means of its A-X (0, 0) transitions near 226 nm. We tested two probes on selected explosives and modeled their electric field in the presence of a substrate with an ion optics simulation program. The limits of detection range from 1 to 15 ng/cm(2) (signal-to-noise ratio of 3) at 1 atm and 298 K and depend on the electrode orientation and mechanism for NO formation. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21010 USA. RP Cabalo, J (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM sausa@arl.army.mil NR 27 TC 23 Z9 23 U1 1 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 20 PY 2005 VL 44 IS 6 BP 1084 EP 1091 DI 10.1364/AO.44.001084 PG 8 WC Optics SC Optics GA 900GN UT WOS:000227203500029 PM 15751700 ER PT J AU Hartzell, JD Aronson, N AF Hartzell, JD Aronson, N TI Resources for management of cutaneous leishmaniasis SO AMERICAN FAMILY PHYSICIAN LA English DT Letter C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Hartzell, JD (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 15 PY 2005 VL 71 IS 4 BP 663 EP 663 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 899OJ UT WOS:000227153700002 PM 15742905 ER PT J AU Lieberman, HR Bathalon, GP Falco, CM Kramer, FM Morgan, CA Niro, P AF Lieberman, HR Bathalon, GP Falco, CM Kramer, FM Morgan, CA Niro, P TI Severe decrements in cognition function and mood induced by sleep loss, heat, dehydration, and undernutrition during simulated combat SO BIOLOGICAL PSYCHIATRY LA English DT Article DE vigilance; cortisol; nutrition; fatigue; stress; performance ID SALIVARY CORTISOL; VISUAL VIGILANCE; D-AMPHETAMINE; PERFORMANCE; STRESS; DEPRIVATION; CAFFEINE; HUMANS; MEN; MELATONIN AB Background: Military exercises generate high levels of stress to simulate combat, providing a unique opportunity to examine cognitive and physiologic responses of normal humans to acute stress. Methods: Cognitive and physiologic markers of stress were evaluated before, during, and after an intense training exercise conducted for 53 hours in the heat. Cognitive performance, mood, physical activity, sleep, body composition, hydration, and saliva cortisol, testosterone, and melatonin were assessed. Volunteers were 31 male US. Army officers from an elite unit, aged 37.6 +/- 4 years. Results: Wrist activity monitors documented that soldiers slept only 3.0 +/- 3 hours during the exercise and were active throughout. Volunteers lost 4.1.2 kg (p < .001) of weight, predominately water (3.1 +/- 3 L) (p < .001). Substantial degradation in cognitive function, assessed with computerized tests, occurred. Vigilance, reaction time, attention, memory, and reasoning were impaired (p < .001). Mood, including vigor (p < .001),fatigue (p < .001), coiffitision (p < .001), depression (p < .001), and tension (p < .002), assessed by questionnaire, deteriorated. The highest cortisol and testosterone levels were observed before the exercise. Conclusions: This study quantifies the overwhelmingly adverse impact of multiple stressors on cognitive performance, mood, and physiologic parameters, during a continuous but brief military exercise conducted by highly motivated, well-trained officers. C1 USA, Environm Med Res Inst, Milit Nutr Div, Natick, MA 01760 USA. USA, Natick Res Dev & Engn Ctr, Sci & Technol Directorate, Natick, MA 01760 USA. Yale Univ, Sch Med, New Haven, CT USA. Yale Univ, Natl Ctr PTSD, New Haven, CT USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Milit Nutr Div, Natick, MA 01760 USA. EM harris.lieberman@na.amedd.army.mil NR 37 TC 110 Z9 118 U1 6 U2 37 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD FEB 15 PY 2005 VL 57 IS 4 BP 422 EP 429 DI 10.1016/j.biopsych.2004.11.014 PG 8 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 898KJ UT WOS:000227075400014 PM 15705359 ER PT J AU Lewis, MD Serichantalergs, O Pitarangsi, C Chuanak, N Mason, CJ Regmi, LR Pandey, P Laskar, R Shrestha, CD Malla, S AF Lewis, MD Serichantalergs, O Pitarangsi, C Chuanak, N Mason, CJ Regmi, LR Pandey, P Laskar, R Shrestha, CD Malla, S TI Typhoid fever: A massive, single-point source, multidrug-resistant outbreak in Nepal SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID ENTERICA SEROTYPE TYPHI; SEROVAR-PARATYPHI-A; FLUOROQUINOLONE BREAKPOINTS; SALMONELLA-TYPHIMURIUM; UNITED-KINGDOM; BONE-MARROW; BLOOD; TAJIKISTAN; EPIDEMIC; SUSCEPTIBILITY AB Background. In the summer of 2002, a total of 5963 cases of typhoid fever were recorded in Bharatpur, Nepal (population, 92,214) during a 7-week period. A team from the Armed Forces Research Institute of Medical Sciences in Bangkok, Thailand, and the CIWEC Travel Medicine Clinic (Kathmandu, Nepal) assisted the Nepal National Public Health Laboratory (Kathmandu, Nepal) in the further investigation of this large, explosive febrile disease outbreak. Methods. Investigators conducted a thorough epidemiologic and laboratory investigation to assess the size and scope of the outbreak. In addition to subculturing of previously collected samples, blood samples were obtained from 100 febrile patients, and culture and susceptibility testing were done by standard laboratory methods. Pulsed field gel electrophoresis (PFGE) and plasmid analysis were done. Results. The majority of the isolates, including 1 from the municipal water supply, were multidrug resistant. The minimum inhibitory concentrations (MICs) of ciprofloxacin ranged from 0.19 mug/mL to 0.125 mug/mL. With use of PFGE, all isolates, including isolates from the water supply, showed an analytical similarity of 96% - 100%. Multidrug-resistant isolates had a plasmid encoding for resistance, and those with resistance to nalidixic acid had a single-point mutation. Conclusions. To the best of our knowledge, this outbreak is the largest single - point source outbreak of multidrug-resistant typhoid fever yet reported, and it was molecularly traced to the city's single municipal water supply. Isolates were uniformly resistant to nalidixic acid, there was a decrease in their susceptibility as measured by MIC of fluoroquinolones, and 90% of isolates obtained were resistant to 11 antibiotic. C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Bharatpur Zonal Hosp, Kathmandu, Nepal. CIWEC Travel Clin, Kathmandu, Nepal. Bharatpur Coll Med Sci, Kathmandu, Nepal. Nepal Natl Publ Hlth Lab, Kathmandu, Nepal. RP Lewis, MD (reprint author), 11723 Devilwood Dr, Potomoc, MD 20854 USA. EM Michael.Lewis14@us.army.mil OI MASON, CARL/0000-0002-3676-2811 NR 22 TC 37 Z9 41 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 15 PY 2005 VL 40 IS 4 BP 554 EP 561 DI 10.1086/427503 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 904JN UT WOS:000227492600009 PM 15712078 ER PT J AU Shorr, AF Zadeikis, N Jackson, WL Ramage, AS Wu, SC Tennenberg, AM Kollef, MH AF Shorr, AF Zadeikis, N Jackson, WL Ramage, AS Wu, SC Tennenberg, AM Kollef, MH TI Levofloxacin for treatment of ventilator-associated pneumonia: A subgroup analysis from a randomized trial SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID INTENSIVE-CARE UNITS; GRAM-NEGATIVE BACILLI; NOSOCOMIAL PNEUMONIA; INTRAVENOUS CIPROFLOXACIN; HOSPITALIZED-PATIENTS; IMIPENEM/CILASTATIN; SUSCEPTIBILITY; MULTICENTER; RESISTANCE; THERAPY AB Ventilator-associated pneumonia (VAP) remains a significant challenge in critical care. We conducted a secondary analysis of a multicenter, prospective, randomized trial comparing levofloxacin (750 mg iv q24h) with imipenem-cilastatin (500-1000 mg iv q6-8h) for treatment of nosocomial pneumonia and focused on the subgroup of patients with VAP. The study cohort included 222 patients, with half (I 11) of the patients assigned to each treatment group. The patients in both groups were similar with respect to age, severity of illness, and duration of mechanical ventilation before the onset of VAP. Among the intention-to-treat population, clinical success was achieved in 58.6% of patients receiving levofloxacin, compared with 63.1% of patients receiving imipenem-cilastatin (P =.49; 95% confidence interval for the difference, -8.77% to 17.79%). Microbiological success and 28-day mortality rates were also comparable. Multivariate analysis demonstrated that assignment to antibiotic treatment (i.e., levofloxacin vs. imipenem-cilastatin) was not predictive of outcomes, thus suggesting that the treatment regimens were equivalent. Both levofloxacin and imipenem-cilastatin regimens were well tolerated and had similar adverse event profiles. C1 Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Crit Care Med Serv, Washington, DC 20307 USA. OrthoMcNeil Pharmaceut, Raritan, NJ USA. Dwight D Eisenhower Army Med Ctr, Crit Care Med Serv, Augusta, GA USA. Tibotec, Yardley, PA USA. Washington Univ, Barnes Jewish Hosp, Med Intens Care Unit, Sch Med, St Louis, MO USA. RP Shorr, AF (reprint author), Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM afshorr@dnamail.com; nzadeiki@ompus.jnj.com NR 19 TC 14 Z9 18 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 15 PY 2005 VL 40 SU 2 BP S123 EP S129 DI 10.1086/426192 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 898EV UT WOS:000227059900006 PM 15712100 ER PT J AU Shorr, AF Susla, GB Kollef, MH AF Shorr, AF Susla, GB Kollef, MH TI Quinolones for treatment of nosocomial pneumonia: A meta-analysis SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID VENTILATOR-ASSOCIATED PNEUMONIA; INTENSIVE-CARE UNITS; HOSPITAL-ACQUIRED PNEUMONIA; GRAM-NEGATIVE BACILLI; INTRAVENOUS CIPROFLOXACIN; ANTIMICROBIAL THERAPY; ANTIBIOTIC-TREATMENT; PHARMACOKINETICS; LEVOFLOXACIN; IMIPENEM/CILASTATIN AB Although quinolones are often used to treat nosocomial pneumonia (NP), there have been few trials documenting their efficacy in treating NP. Given the growing use of quinolones and issues regarding resistance, we conducted a meta-analysis of all trials of quinolones for treatment of NP. We identified 5 randomized trials comparing quinolones with other agents used to treat NP. The studies varied in both quality and sample size and included a total of nearly 1200 subjects. Four of the 5 trials used ciprofloxacin, administered every 8 h, whereas the fifth used levofloxacin administered daily. In 3 trials, the comparator agent was imipenem-cilistatin, whereas, in 2 trials, ceftazadime was the comparator agent. The efficacy of quinolones and comparator antibiotics was similar, with a pooled odds ratio for clinical cure of 1.12 (95% confidence interval, 0.80-1.55). Neither microbiological eradication rates nor mortality rates varied on the basis of antimicrobial selection. C1 Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. Voluntary Hosp Assoc Amer, N Potomac, MD USA. Washington Univ, Barnes Jewish Hosp, Med Intens Care Unit, St Louis, MO USA. RP Shorr, AF (reprint author), Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM afshorr@dnamail.com; mkollef@im.wustl.edu NR 33 TC 7 Z9 10 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 15 PY 2005 VL 40 SU 2 BP S115 EP S122 DI 10.1086/426191 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 898EV UT WOS:000227059900005 PM 15712099 ER PT J AU Zimmerman, JR Luthy, RG Ghosh, U Millward, RN Bridges, TS AF Zimmerman, JR Luthy, RG Ghosh, U Millward, RN Bridges, TS TI Response to comment on "Addition of carbon sorbents to reduce PCB and PAH: Bioavailability in marine sediments: Physicochemical tests" SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Letter C1 Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. Univ Maryland Baltimore Cty, Dept Civil & Environm Engn, Baltimore, MD 21250 USA. USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Luthy, RG (reprint author), Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. NR 10 TC 2 Z9 3 U1 1 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 15 PY 2005 VL 39 IS 4 BP 1199 EP 1200 DI 10.1021/es047983a PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 897KB UT WOS:000227001700039 ER PT J AU Powell, SK Goldsman, N Lelis, A McGarrity, JM McLean, FB AF Powell, SK Goldsman, N Lelis, A McGarrity, JM McLean, FB TI High-temperature modeling and characterization of 6H silicon carbide metal-oxide-semiconductor field-effect transistors SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB We expand upon previous work [S. K. Powell, N. Goldsman, J. M. McGarrity, J. Bernstein, C. J. Scozzie, and A. Lelis, J. Appl. Phys. 92, 4053 (2002)] by applying the device model to 6H silicon carbide metal-oxide-semiconductor field-effect transistors operating at high temperatures. We compare the model predictions with the device measurements from room temperature to 200 degreesC and find agreement. (C) 2005 American Institute of Physics. C1 Univ Maryland, Dept Elect Engn, College Pk, MD 20742 USA. USA, Res Lab, Adelphi, MD 20783 USA. USA, Res Lab Consultants, Adelphi, MD 20783 USA. RP Powell, SK (reprint author), Univ Maryland, Dept Elect Engn, College Pk, MD 20742 USA. EM neil@glue.umd.edu NR 7 TC 2 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 15 PY 2005 VL 97 IS 4 AR 046106 DI 10.1063/1.1849424 PG 3 WC Physics, Applied SC Physics GA 895DU UT WOS:000226841900107 ER PT J AU Cheng, H Fang, SC Lavery, JE AF Cheng, H Fang, SC Lavery, JE TI Shape-preserving properties of univariate cubic L-1 splines SO JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS LA English DT Article DE convexity; cubic L-1 spline; geometric programming; interpolation; linearity; shape preservation ID MULTISCALE INTERPOLATION AB The results in this paper quantify the ability of cubic L-1 splines to preserve the shape of nonparametric data. The data under consideration include multiscale data, that is, data with abrupt changes in spacing and magnitude. A simplified dual-to-primal transformation for a geometric programming model for cubic L-1 splines is developed. This transformation allows one to establish in a transparent manner relationships between the shape-preserving properties of a cubic L-1 spline and the solution of the dual geometric-programming problem. Properties that have often been associated with shape preservation in the past include preservation of linearity and convexity/concavity. Under various circumstances, cubic L-1 splines preserve linearity and convexity/concavity of data. When four consecutive data points lie on a straight line, the cubic L-1 spline is linear in the interval between the second and third data points. Cubic L-1 splines of convex/concave data preserve convexity/concavity if the first divided differences of the data do not increase/decrease too rapidly. When cubic L-1 splines do not preserve convexity/concavity, they still do not cross the piecewise linear interpolant and, therefore, they do not have extraneous oscillation. (C) 2004 Elsevier B.V. All rights reserved. C1 N Carolina State Univ, Raleigh, NC 27695 USA. USA, Res Off, Res Lab, Div Math, Res Triangle Pk, NC 27709 USA. RP Cheng, H (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA. EM hao.cheng@sas.com; fang@eos.ncsu.edu; john.lavery2@us.army.mil NR 22 TC 15 Z9 15 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-0427 J9 J COMPUT APPL MATH JI J. Comput. Appl. Math. PD FEB 15 PY 2005 VL 174 IS 2 BP 361 EP 382 DI 10.1016/j.cam.2004.05.003 PG 22 WC Mathematics, Applied SC Mathematics GA 876WV UT WOS:000225530300010 ER PT J AU Burgess, EB AF Burgess, EB TI Mimi and Toutou's big adventure: The bizarre battle of Lake Tanganyika. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD FEB 15 PY 2005 VL 130 IS 3 BP 143 EP 144 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 896RZ UT WOS:000226952500162 ER PT J AU West, BJ Griffin, LA Frederick, HJ Moon, RE AF West, BJ Griffin, LA Frederick, HJ Moon, RE TI The independently fractal nature of respiration and heart rate during exercise under normobaric and hyperbaric conditions SO RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY LA English DT Article DE heart rate; R-R interval; fractal character; mammals; humans; pattern of breathing; fractal character; pressure; hyperbaric chamber ID RATE-VARIABILITY; TIME-SERIES; HUMAN GAIT; DYNAMICS; INTERVAL; WALKING; SLEEP; CHAOS AB To test the hypothesis that the fractal character of breathing and heart rate are independent, inter-breath intervals (IBI) and R-R intervals (RRI) were measured during rest and two levels of exercise at 2 and 2.8 ATA in a hyperbaric chamber in 18 male and female subjects (ages 19-74 years). Both RRI and IBI showed fractal properties. Fractal dimensions (D) for IBI were (mean +/- S.D.) 1.33 +/- 0.11, 1.29 +/- 0.12, 1.19 +/- 0.16 (rest, light and heavy exercise at 1 ATA); 1.33 +/- 0.13, 1.25 +/- 0.13, 1.18 +/- 0.14 (same conditions at 2.8 ATA). Corresponding D for RRI were 1.19 +/- 0.11, 1.05 +/- 0.07 and 1.02 +/- 0.05 (1 ATA); 1.20 +/- 0.10, 1.03 +/- 0.04 and 1.01 +/- 0.02 (2.8 ATA). The fractal dimension of each variable decreased with exercise and was unaffected by hyperbaric exposure. These two systems were not cross-correlated under any of the six conditions. During rest and light and moderate exercise at 1 and 2.8 ATA the results are consistent with heart rate variability and breathing rate variability being mutually independent of one another. (C) 2004 Elsevier B.V. All rights reserved. C1 Duke Univ, Dept Anesthesiol, Durham, NC USA. Duke Univ, Dept Med, Durham, NC USA. Duke Univ, Ctr Hyperbar Med & Environm Physiol, Durham, NC USA. Univ Texas, Med Branch, Sch Allied Hlth Sci, Galveston, TX 77550 USA. Duke Univ, Dept Phys, Durham, NC 27706 USA. USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. RP Moon, RE (reprint author), Duke Univ, Dept Anesthesiol, Durham, NC USA. EM richard.moon@duke.edu RI West, Bruce/E-3944-2017 NR 36 TC 20 Z9 20 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1569-9048 J9 RESP PHYSIOL NEUROBI JI Respir. Physiol. Neuro. PD FEB 15 PY 2005 VL 145 IS 2-3 BP 219 EP 233 DI 10.1016/j.resp.2004.07.010 PG 15 WC Physiology; Respiratory System SC Physiology; Respiratory System GA 901ZD UT WOS:000227319900011 PM 15705537 ER PT J AU Kuklo, TR Potter, BK Polly, DW O'Brien, MF Schroeder, TM Lenke, LG AF Kuklo, TR Potter, BK Polly, DW O'Brien, MF Schroeder, TM Lenke, LG TI Reliability analysis for manual adolescent idiopathic scoliosis measurements SO SPINE LA English DT Article DE intraobserver reliability; interobserver reliability; manual measurement; radiographic process measure; adolescent idiopathic scoliosis ID PROXIMAL THORACIC CURVE; TERM FOLLOW-UP; COTREL-DUBOUSSET INSTRUMENTATION; MEASURE VERTEBRAL ROTATION; SAGITTAL SPINAL ALIGNMENT; PEDICLE SCREW FIXATION; LOW-BACK-PAIN; SURGICAL-MANAGEMENT; LUMBAR LORDOSIS; TECHNIQUE VARIABILITY AB Study Design. Manual radiographic measurement analysis. Objectives. To determine the intraobserver and interobserver reliability of numerous radiographic process measures used in the assessment of adolescent idiopathic scoliosis. Summary of Background Data. Analysis of scoliosis requires a thorough radiographic evaluation to completely assess the deformity. Numerous radiographic process measures have been studied extensively and used for outcomes assessment and thus become the de facto standard of care. However, many of these measures have not been evaluated to determine the reliability and reproducibility. Validation of radiographic process measures is necessary to compare these measures with patient-focused outcome measures, as well as to permit valid comparison of different surgical techniques. Methods. Thirty complete sets of long-cassette scoliosis radiographs (anteroposterior [AP], lateral and side-bending preoperative and AP, and lateral postoperative) were analyzed by three independent experienced observers on two separate occasions. Coronal image measures included the coronal Cobb angles, side-bending Cobb, apical vertebral translation, coronal balance, T1 tilt, lowest instrumented vertebrae (LIV) tilt, angulation of the disc below the LIV, apical vertebral rotation (Nash-Moe), and Risser sign; sagittal measures included T2-T5, T5-T12, T2-T12, T10-L2, T12-S1, and sagittal balance. Intraobserver and interobserver reliability for each measure was then assessed. Results. The vast majority of the radiographic process measures assessed demonstrated good to excellent or excellent intraobserver and interobserver reliability. However, the angulation of the disc below the LIV demonstrated only fair interobserver reliability for postoperative measurements (rho = 0.59). Likewise, Risser grade measurements reflected good intraobserver (0.81-0.99) but only fair interobserver reliability (0.60-0.70). Apical vertebral rotation assessed by the technique of Nash and Moe produced good intraobserver reliability before surgery (0.74-0.85) but only fair reliability after surgery (0.50-0.85). The interobserver reliability for apical Nash-Moe rotation was fair to poor (0.53-0.59). For T2-T5 regional kyphosis, intraobserver (0.22-0.83) and interobserver (0.33-0.47) reliability was generally poor. Overall, the reliability of postoperative measurements tended to be decreased relative to preoperative values, likely due to instrumentation overlying radiographic landmarks. Conclusions. Most of the radiographic process measures evaluated in this study demonstrated good or excellent reliability. The reliability of measuring the angulation of the disc below the LIV, the apical Nash-Moe rotation, and Risser grading was decreased relative to other measures. The reliability of measuring T2-T5 regional kyphosis was disappointing and poor. With regards to the other 13 measures assessed, our findings support the use of these process measures obtained by experienced deformity surgeons via manual measurement for routine clinical and academic purposes. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Univ Minnesota, Dept Orthopaed Surg, Minneapolis, MN 55455 USA. Miami Childrens Hosp, Dept Orthopaed Surg, Miami, FL USA. Washington Univ, Sch Med, Dept Spinal Surg, St Louis Shriners Hosp Children, St Louis, MO USA. Washington Univ, Dept Orthopaed Surg, St Louis, MO USA. RP Kuklo, TR (reprint author), 15619 Thistlebridge Dr, Rockville, MD 20853 USA. EM Timothy.Kuklo@na.amedd.army.mil NR 80 TC 44 Z9 51 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD FEB 15 PY 2005 VL 30 IS 4 BP 444 EP 454 DI 10.1097/01.brs.0000153702.99342.9c PG 11 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 898PK UT WOS:000227088500012 PM 15706343 ER PT J AU Abbott, KC Koff, J Bohen, EM Oglesby, RJ Agodoa, LYC Lentine, KL Schnitzler, MA AF Abbott, KC Koff, J Bohen, EM Oglesby, RJ Agodoa, LYC Lentine, KL Schnitzler, MA TI Maintenance immunosuppression use and the associated risk of avascular necrosis after kidney transplantation in the United States SO TRANSPLANTATION LA English DT Article DE avascular necrosis; medicare claim; renal transplant; female; peritoneal dialysis; cyclosporine A; tacrolimus; US renal database system ID BONE-MARROW EDEMA; RENAL-TRANSPLANTATION; FEMORAL-HEAD; THROMBOTIC MICROANGIOPATHY; MYCOPHENOLATE-MOFETIL; DIABETES-MELLITUS; GRAFT-SURVIVAL; PAIN SYNDROME; SINGLE-CENTER; OSTEONECROSIS AB Background. Avascular necrosis (AVN) after renal transplantation has been largely attributed to the use of corticosteroids. However, other risk factors such as microvascular thrombosis and hyperlipidemia have been well described and may be of increased importance in the era of early steroid cessation and avoidance. We hypothesized that maintenance immunosuppressive medications known to be associated with these risk factors for AVN would also be associated with a higher risk of AVN. Methods. By using the U.S. Renal Data System database, we studied 27,772 primary patients on Medicare who received a solitary kidney transplant between January 1, 1996, and July 31, 2000. Cox proportional hazards regression models were used to calculate adjusted hazard ratios (AHRs) for patient- and transplant-related factors (including allograft rejection) with Medicare claims for AVN. The intensity and duration of corticosteroid use could not be assessed. Results. Among patients who were prescribed sirolimus at discharge, 3.5% of patients who received the combination of sirolimus-cyclosporine A (CsA) demonstrated AVN, compared with 1.4% of patients who received the combination of siroli-mus-tacrolimus (P=0.06 by chi(2)). In Cox regression, CsA use (vs. tacrolimus) (AHR 1.36, 95% confidence interval, 1.09-1.71) was independently associated with an increased risk of AVN. Sirolimus use showed a trend toward significance (AHR 1.59, 95% confidence interval, 0.99-2.56), with no significant interaction with CsA. Conclusions. Compared with other maintenance immunosuppression, AVN was significantly more common after use of CsA prescribed at the time of discharge for renal transplantation. Whether this increased risk of AVN was directly attributable to hyperlipidemia, microvascular thrombosis, or differences in corticosteroid dosing could not be determined. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Serv Gastroenterol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Rheumatol Serv, Washington, DC 20307 USA. NIDDK, NIH, Bethesda, MD USA. St Louis Univ, Sch Med, Ctr Outcomes Res, St Louis, MO USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM kevin.abbott@na.amedd.army.mil RI ieong, bee/C-5840-2012; OI Abbott, Kevin/0000-0003-2111-7112 NR 46 TC 12 Z9 13 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD FEB 15 PY 2005 VL 79 IS 3 BP 330 EP 336 DI 10.1097/01.TP.0000149894.95435.7F PG 7 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 898NH UT WOS:000227083000011 PM 15699764 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of methylthiogermane SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; methylthiogermane; germylmethylsulfide ID HIGH-YIELD SYNTHESIS; DERIVATIVES; SPECTRA; SULPHIDE; GERMANE; SILANE; GERMYL; DIMETHYL; SULFIDE AB The vibrational frequencies and the corresponding normal mode assignments of methylthiogermane (CH3SGeH3) are examined theoretically using the GAUSSIAN98 set of quantum chemistry codes. All normal modes were successfully assigned to one of the I I types of motion predicted by a group theoretical analysis (C-H stretch, Ge-H stretch, C-S stretch, Ge-S stretch, H-C-H bend, H-Ge-H bend, Ge-S-C bend, CH3 rock, CH3 twist. GeH3 rock, and GeH3 twist). Theoretical infrared and Raman intensities are reported. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSRD,ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD,ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 18 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD FEB 14 PY 2005 VL 714 IS 2-3 BP 117 EP 121 DI 10.1016/j.theochem.2004.08.059 PG 5 WC Chemistry, Physical SC Chemistry GA 898WC UT WOS:000227105900005 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of thiocyanogen SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; thiocyanogen ID NORMAL-COORDINATE ANALYSIS; CRYSTAL-STRUCTURE; SPECTRA; SPECTROSCOPY; MOLECULES; (SCN)2; SULFUR AB The vibrational frequencies and corresponding normal mode assignments of thiocyanogen are examined theoretically using the Gaussian03 set of quantum chemistry codes. All normal modes were successfully assigned to one of six types of motion (CdropN stretch, C-S stretch, S-S stretch. S-CdropN bend, C-S-S bend, C-S-S-C torsion) utilizing the C-2 symmetry of the molecule. Molecular orbitals and bonding are examined. Published by Elsevier B.V.. C1 USA, Edgewood Chem & Biol Ctr, AMSRD, ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD, ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 35 TC 5 Z9 5 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD FEB 14 PY 2005 VL 714 IS 2-3 BP 137 EP 141 DI 10.1016/j.theochem.2004.09.046 PG 5 WC Chemistry, Physical SC Chemistry GA 898WC UT WOS:000227105900008 ER PT J AU Cao, XH Mabrouki, M Mello, SV Leblanc, RM Rastogi, VK Cheng, TC DeFrank, JJ AF Cao, XH Mabrouki, M Mello, SV Leblanc, RM Rastogi, VK Cheng, TC DeFrank, JJ TI The interaction between OPH and paraoxon at the air-water interface studied by AFM and epifluorescence microscopies SO COLLOIDS AND SURFACES B-BIOINTERFACES LA English DT Article DE organophosphorus hydrolase; atomic force microscopy; paraoxon ID PARATHION HYDROLASE GENE; LANGMUIR-BLODGETT-FILMS; ATOMIC-FORCE MICROSCOPY; BINUCLEAR METAL CENTER; PSEUDOMONAS-DIMINUTA; BACTERIAL PHOSPHOTRIESTERASE; ORGANOPHOSPHORUS HYDROLASE; 3-DIMENSIONAL STRUCTURE; ACTIVE-SITE; ENZYME AB The paraoxon hydrolysis reaction catalyzed by organophosphorus hydrolase (OPH) monolayer at the air-water interface was studied. OPH-paraoxon interactions, occurring at the two-dimensional interface, by close-packed, highly orientated OPH monolayer, were investigated by several different surface chemistry techniques; e.g. surface pressure area isotherms, atomic force microscopy (AFM), and in situ epifluorescence microscopy. The characterization of OPH Langmuir and Langmuir-Blodgett films prepared in both the presence and absence of paraoxon, demonstrated significantly distinctive feature when compared with one another. Continuous growth of the OPH aggregates is a distinct phenomenon associated with hydrolysis, in addition to the pH changes in the local environment of the enzyme macromolecules. (C) 2004 Elsevier B.V. All rights reserved. C1 Univ Miami, Dept Chem, Coral Gables, FL 33124 USA. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Leblanc, RM (reprint author), Univ Miami, Dept Chem, Coral Gables, FL 33124 USA. EM rml@miami.edu RI MABROUKI, Mustapha/B-2421-2012 OI MABROUKI, Mustapha/0000-0001-8975-9803 NR 27 TC 5 Z9 5 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-7765 J9 COLLOID SURFACE B JI Colloid Surf. B-Biointerfaces PD FEB 10 PY 2005 VL 40 IS 2 BP 75 EP 81 DI 10.1016/j.colsurfb.2004.05.009 PG 7 WC Biophysics; Chemistry, Physical; Materials Science, Biomaterials SC Biophysics; Chemistry; Materials Science GA 893KE UT WOS:000226717000002 PM 15642457 ER PT J AU Noy, A Scadden, DT Lee, J Dezube, BJ Aboulafia, D Tulpule, A Walmsley, S Gill, P AF Noy, A Scadden, DT Lee, J Dezube, BJ Aboulafia, D Tulpule, A Walmsley, S Gill, P TI Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: From the AIDS malignancy consortium and IM862 study team SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article; Proceedings Paper CT 6th International Conference on Malignancies in AIDS and Other Immuneodeficiencies CY APR 22-24, 2002 CL Bethesda, MD ID CLINICAL-TRIALS; PROTEASE INHIBITORS; IN-VIVO; HERPESVIRUS; LYMPHOMA; CELLS AB Purpose IM862 is a synthetic dipeptide (L-glutamine L-tryptophan) with in vitro and in vivo antiangiogenic properties. Phase I/II studies showed minimal toxicity and a response rate of 36% in AIDS-Kaposi's sarcoma. We report a 24-week, randomized, double-blinded, placebo-controlled phase III trial with the phase II dose, 5 mg intranasally every other day. Patients and Methods Two hundred two HIV-positive patients were enrolled, 104 on IM862 and 98 on placebo. Results Baseline characteristics were comparable except current antiretroviral therapy: 88% versus 96% (IM862 v placebo group; P =.042). The median treatment durations were 19.5 versus 24 weeks (IM862 v placebo). No significant difference was detected in response rate (IM862, 23%; 95% Cl, 15% to 32% v placebo, 21%; 95% Cl, 14% to 31%; P =.46), time to response (8.5 weeks v 14 weeks; P =.024), or duration of response. However, IM862 was associated with both a shorter time to response (8.5 weeks v 14 weeks; P =.024) and shorter median time to progression (16 weeks, 95% Cl, 13 to 27 weeks v 35 weeks, 95% Cl, 26 to 114 weeks; P =.012). Conclusion Despite promising phase I and phase 11 studies, IM862 5 mg every other day was not superior to placebo and may accelerate time to progression. Highly active antiretroviral therapy alone was associated with a substantial rate of sustained tumor response and may have contributed to prior estimates of IM862 response. Therapeutic trials for AIDS-Kaposi's sarcoma must account for ongoing immune reconstitution in the setting of concurrent highly active antiretroviral therapy that may confound estimates of therapeutic activity. (C) 2005 by American Society of Clinical Oncology. C1 Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. USC, Keck Sch Med, Norris Canc Inst, Los Angeles, CA USA. Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cambridge, MA 02138 USA. Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. Univ Birmingham, AMC Operat & Stat Ctr, Birmingham, AL USA. Univ Washington, Virginia Mason Clin, Seattle, WA USA. Univ Toronto, Toronto Hosp, Toronto, ON, Canada. RP Noy, A (reprint author), Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA. EM noya@mskcc.org OI Noy, Ariela/0000-0002-3001-4898 FU NCI NIH HHS [U01CA70062, U01CA070081, U01CA071375, U01CA070054, U01CA083038, U01CA070072, U01CA070068, U01CA070075, U01CA070079, U01CA83035, U01CA070047, U01CA070080, U01CA083118, U01CA070019] NR 35 TC 27 Z9 30 U1 0 U2 1 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD FEB 10 PY 2005 VL 23 IS 5 BP 990 EP 998 DI 10.1200/JCO.2005.11.043 PG 9 WC Oncology SC Oncology GA 896ZC UT WOS:000226972300007 PM 15598977 ER PT J AU Somiari, RI Somiari, S Russell, S Shriver, CD AF Somiari, RI Somiari, S Russell, S Shriver, CD TI Proteomics of breast carcinoma SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE reviews; proteomics ID LASER CAPTURE MICRODISSECTION; PROTEIN IDENTIFICATION TECHNOLOGY; DIFFERENTIAL GEL-ELECTROPHORESIS; CODED AFFINITY TAGS; DUCTAL CARCINOMA; IN-SITU; 2-DIMENSIONAL ELECTROPHORESIS; CANCER; DISCOVERY; MARKERS AB Beast cancer is the most diagnosed cancer in women, accounting for approximately 40,000 deaths annually in the USA. Significant advances have been made in the areas of detection and treatment, but a significant number of breast cancers are detected late. The advent of proteomics provides the hope of discovering novel biological markers that can be used for early detection, disease diagnosis, prognostication and prediction of response to therapy. Several proteomics technologies including 2D-PAGE, 2D-DIGE, ICAT, SELDI-TOF, MudPIT and protein arrays have been used to uncover molecular mechanisms associated with breast carcinoma at the global level, and a number of these technologies, particularly the SELDI-TOF hold promise as a proteomic approach that can be applied at the bedside for discovering protein patterns that distinguish disease and disease-free states with high sensitivity and specificity. Laser microdissection, a method for selection of homogenous cell populations, coupled to 2D-DIGE or MudPIT constitute a new proteomics-based paradigm for detecting disease in pathology specimens and monitoring disease response to therapy. This review describes proteomics technologies, and their application in the proteomic analysis of breast carcinoma. (C) 2004 Elsevier B.V. All rights reserved. C1 ITSI Biosci, Funct Genom & Proteom, Johnstown, PA 15904 USA. Windber Res Inst, Clin Breast Care Project, Windber, PA USA. Walter Reed Army Med Ctr, Gen Surg Serv, Clin Breast Care Project, Washington, DC 20307 USA. RP Somiari, RI (reprint author), ITSI Biosci, Funct Genom & Proteom, 938 Mt Airy Dr, Johnstown, PA 15904 USA. EM richard@itsi.us NR 67 TC 76 Z9 90 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD FEB 5 PY 2005 VL 815 IS 1-2 BP 215 EP 225 DI 10.1016/j.jchromb.2004.11.012 PG 11 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 895RC UT WOS:000226879700019 PM 15652811 ER PT J AU Towner, JS Paragas, J Dover, JE Gupta, M Goldsmith, CS Huggins, JW Nichol, ST AF Towner, JS Paragas, J Dover, JE Gupta, M Goldsmith, CS Huggins, JW Nichol, ST TI Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening SO VIROLOGY LA English DT Article DE Zaire ebolavirus; hemorrhagic disease; cGFP; recombinant virus ID VIRUS INFECTION; FILOVIRUS INFECTIONS; HEMORRHAGIC-FEVER; RHESUS-MONKEYS; MOUSE MODEL; IN-VITRO; GLYCOPROTEIN; REPLICATION; ALPHA; CELLS AB Zaire ebolavirus causes large outbreaks of severe and usually fatal hemorrhagic disease in humans for which there is no effective treatment or cure. To facilitate examination of early critical events in viral pathogenesis and to identify antiviral compounds, a recombinant Zaire ebolavirus was engineered to express a foreign protein, eGFP, to provide a rapid and sensitive means to monitor virus replication in infected cells. This genetically engineered virus represents the first insertion of a foreign gene into ebolavirus. We show that Ebola-eGFP virus (EboZ-eGFP) infects known early targets of human infections and serves as an ideal model to screen antiviral compounds in less time than any previously published assay. Published by Elsevier Inc. C1 Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Special Pathogens Branch, NCID, Atlanta, GA 30333 USA. USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Infect Dis Pathol Activ, NCID, Atlanta, GA 30333 USA. RP Nichol, ST (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Special Pathogens Branch, NCID, Mailstop G14,1600 Clifton Rd, Atlanta, GA 30333 USA. EM stn1@cdc.gov NR 20 TC 85 Z9 90 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD FEB 5 PY 2005 VL 332 IS 1 BP 20 EP 27 DI 10.1016/j.virol.2004.10.048 PG 8 WC Virology SC Virology GA 892ZM UT WOS:000226688500004 PM 15661137 ER PT J AU Zhang, SS Xu, K Jow, TR AF Zhang, SS Xu, K Jow, TR TI An inorganic composite membrane as the separator of Li-ion batteries SO JOURNAL OF POWER SOURCES LA English DT Article DE composite membrane; separator; ionic conductivity; high-rate performance; Li-ion battery ID NATURAL GRAPHITE; ELECTRIC VEHICLES; ANODE MATERIALS; CELLS AB We studied an inorganic composite membrane as the separator for Li-ion batteries. Being made of mainly CaCO3 powder and a small amount of polymer binder, the composite membrane has excellent wettability with liquid electrolytes due to its high porosity, and good capillarity. Ionic conductivity of the membrane can be easily achieved by absorbing a liquid electrolyte. Additional benefit of such a membrane is that the alkali CaCO3 can scavenge acidic HE which is inevitably present in the LiPF6-based electrolytes used currently in the Li-ion batteries. In this work, we typically evaluated a membrane with the composition of 92:8 (wt.) CaCO3/Telfon by using a 1.0 in LiPF6 dissolved in a 3:1 mixture of ethylene carbonate (EC) and ethylmethyl carbonate (EMC) as the liquid electrolyte. Ionic conductivity of the electrolyte-wetted membrane was measured to be 2.4 mS cm(-1) at 20degreesC versus 8.0 mS cm(-1) of the liquid electrolyte. With the said membrane as a separator. both Li/graphite and Li/cathode half-cells exhibited good capacity retention. We also found that the Li-ion cell fabricated in this manner am only had stable capacity retention. but also showed good high-rate performance. (C) 2004 Elsevier B.V. All rights reserved. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 16 TC 85 Z9 94 U1 6 U2 49 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD FEB 2 PY 2005 VL 140 IS 2 BP 361 EP 364 DI 10.1016/j.jpowsour.2004.07.034 PG 4 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 893GO UT WOS:000226707500020 ER PT J AU Klote, MM Smith, LJ AF Klote, MM Smith, LJ TI A case of anaphylaxis to naproxen SO ALLERGY LA English DT Editorial Material DE anaphylaxis; aspirin; cyclooxygenase-1 inhibitor; drug allergy; naproxen; non steroidal anti-inflammatory ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS C1 Walter Reed Army Med Ctr, Dept Allergy, Washington, DC 20307 USA. RP Klote, MM (reprint author), Walter Reed Army Med Ctr, Dept Allergy, Room IJ,6900 Georgia Ave NW, Washington, DC 20307 USA. EM mary-klote@na.amedd.army.mil NR 4 TC 9 Z9 9 U1 0 U2 0 PU BLACKWELL MUNKSGAARD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0105-4538 J9 ALLERGY JI Allergy PD FEB PY 2005 VL 60 IS 2 BP 260 EP 261 DI 10.1111/j.1398-9995.2004.00630.x PG 3 WC Allergy; Immunology SC Allergy; Immunology GA 887VF UT WOS:000226332900022 PM 15647052 ER PT J AU Happe, MR Weiner, HE West, NY AF Happe, MR Weiner, HE West, NY TI Hemorrhagic pustules, tenosynovitis, and arthritis SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material ID GONOCOCCAL ARTHRITIS C1 121st US Army Evacuat Hosp, Seoul, South Korea. RP Happe, MR (reprint author), 121st US Army Evacuat Hosp, Seoul, South Korea. NR 12 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 1 PY 2005 VL 71 IS 3 BP 534 EP 536 PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 897FR UT WOS:000226989900014 PM 15712627 ER PT J AU Taylor, AJ AF Taylor, AJ TI ARBITER-2: ARterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: A double-blind, placebo-controlled study of long-acting niacin on atherosclerosis Progression in secondary prevention patients treated with statins SO AMERICAN HEART JOURNAL LA English DT Meeting Abstract CT 77th Scientific Meeting of the American-Heart-Association CY NOV 07-10, 2004 CL New Orleans, LA SP Amer Heart Assoc ID CONGESTIVE-HEART-FAILURE; LEFT-VENTRICULAR DYSFUNCTION; IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS; CONVERTING-ENZYME INHIBITOR; CRITICALLY ILL PATIENTS; QUALITY-OF-LIFE; MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; FONTAN OPERATION; CLINICAL-TRIAL C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 39 TC 0 Z9 0 U1 0 U2 1 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD FEB PY 2005 VL 149 IS 2 BP 251 EP 253 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 906MD UT WOS:000227645400023 ER PT J AU Kolasa, MW Lee, JC Atwood, JE Marcus, RR Eckart, RE AF Kolasa, MW Lee, JC Atwood, JE Marcus, RR Eckart, RE TI Rotation of QT(c) duration heterogeneity to mortality following orthotopic heart transplantation SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID ALLOGRAFT-REJECTION; QT DISPERSION; INTERVAL AB Studies of heart failure patients have demonstrated that serial QT prolongation and abnormally prolonged QT intervals are associated with greater mortality. Serial QT interval measurements in patients who undergo orthrotopic heart transplantation (OHT) may quantify the degree of myocardial repolarization heterogeneity and serve as a marker of arrhythmogenic substrate. In this study, the mean survival for those with "stable" QT(c) intervals (a change of -10 to 10 ms/year) was 124 +/- 8 months versus 63 +/- 25 months in those with annual QT(c) changes of >10 ms (p = 0.009). Ventricular repolarization heterogeneity may serve as a marker of identifying high-risk patients after OHT. (C) 2005 by Excerpta Medica Inc. C1 Wilford Hall USAF Med Ctr, Dept Cardiol, Serv Cardiol, Lackland AFB, TX 78236 USA. Walter Reed Army Med Ctr, Ctr Med, Serv Cardiol, Washington, DC 20307 USA. Washington Hosp Ctr, Washington, DC 20010 USA. Brooke Army Med Ctr, San Antonio, TX USA. RP Kolasa, MW (reprint author), Wilford Hall USAF Med Ctr, Dept Cardiol, Serv Cardiol, 220 Bergquist Dr,Suite 1, Lackland AFB, TX 78236 USA. EM maik.kolosa@lackland.af.mil NR 7 TC 3 Z9 3 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD FEB 1 PY 2005 VL 95 IS 3 BP 431 EP 432 DI 10.1016/j.amjcard.2004.09.053 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 892WD UT WOS:000226679800029 PM 15670564 ER PT J AU Carter, JR Cooke, WH Ray, CA AF Carter, JR Cooke, WH Ray, CA TI Forearm neurovascular responses during mental stress and vestibular activation SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY LA English DT Article DE otolith stimulation; vestibulosympathetic reflex; arterial pressure control; mental arithmetic ID EMOTIONAL STRESS; HUMANS; VASODILATATION; MUSCLE; OXIDE AB Autonomic responses may underlie associations among anxiety, vestibular dysfunction, and unexplained syncope. Mental stress (MS), an anxiety-inducing stimulus, causes forearm vasodilation, whereas the vestibulosympathetic reflex (VSR) causes forearm vasoconstriction. The purpose of this study was to examine the combined effects of mental and vestibular stimulation on neurovascular control in the forearm. Heart rate, arterial pressure (Finapres), and forearm blood flow (Doppler) were measured in 10 healthy volunteers in the prone position during 1) head-down rotation (HDR), 2) MS ( mental arithmetic), and 3) HDR + MS. Forearm vascular resistance (FVR) increased during HDR ( from 232 +/- 40 to 319 +/- 53 units) and decreased during MS ( from 260 +/- 57 to 154 +/- 22 units). During HDR + MS, FVR did not change [ change (Delta) = - 31 +/- 50 units] and was not significantly different from the algebraic sum of each trial performed alone (Delta = - 20 +/- 42 units). Arm muscle sympathetic nerve activity (MSNA; microneurography) was measured in seven additional subjects. MSNA increased during HDR ( from 13 +/- 2 to 17 +/- 2 bursts/min) and HDR + MS ( from 11 +/- 2 to 16 +/- 2 bursts/min). Increases in MSNA during HDR + MS ( Delta = 5 +/- 2 bursts/min) were not different from the algebraic sum of each trial performed alone ( Delta = 6 +/- 2 bursts/min). We conclude that an additive neurovascular interaction exists between MS and the VSR in the forearm. Activation of the VSR prevented forearm vasodilation during MS, suggesting that activation of the VSR may help protect against stress-induced syncope. C1 Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA. Penn State Univ, Coll Med, Dept Med, Hershey, PA USA. Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Carter, JR (reprint author), Michigan Technol Univ, Dept Biol Sci, 1400 Townsend Dr, Houghton, MI 49931 USA. EM jcarter@mtu.edu FU NCI NIH HHS [CA-00207]; NHLBI NIH HHS [HL-58503]; NIDCD NIH HHS [DC-006459] NR 16 TC 19 Z9 19 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6135 J9 AM J PHYSIOL-HEART C JI Am. J. Physiol.-Heart Circul. Physiol. PD FEB PY 2005 VL 288 IS 2 BP H904 EP H907 DI 10.1152/ajpheart.00569.2004 PG 4 WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Physiology GA 888FE UT WOS:000226358800054 PM 15486035 ER PT J AU Belmusto-Worn, VE Sanchez, JL McCarthy, K Nichols, R Bautista, CT Magill, AJ Pastor-Cauna, G Echevarria, C Laguna-Torres, VA Samame, BK Baldeon, ME Burans, JP Olson, JG Bedford, P Kitchener, S Monath, TP AF Belmusto-Worn, VE Sanchez, JL McCarthy, K Nichols, R Bautista, CT Magill, AJ Pastor-Cauna, G Echevarria, C Laguna-Torres, VA Samame, BK Baldeon, ME Burans, JP Olson, JG Bedford, P Kitchener, S Monath, TP TI Randomized, double-blind, phase III, pivotal field trial of the comparative immunogenicity, safety, and tolerability of two yellow fever 17D vaccines (ARILVAX (TM) and YF-VAX (R)) in healthy infants and children in Peru SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VIRUS; VACCINATION; STRAIN; MONKEYS; DENGUE AB We conducted a randomized, double-blind, phase III yellow fever (YF) vaccine trial among 1,107 healthy children in Sullana in northern Peru. The safety and efficacy (by measurement of geometric mean neutralizing antibody titer responses) were determined for two YF vaccines, ARILVAX(TM) (n = 738) and YF-VAX(R) (n = 369). Seroconversion rates were higher (94.9%) in ARILVAX(TM) than in YF-VAX(R) (90.6%) recipients. The two-sided 95% confidence interval (YF-VAX(R)-ARILVAX(TM),1) was (-12.8% to -2.5%), indicating that the higher seroconversion rate for Arilvax(TM) was significant. Post-vaccination (30-day) mean log,(, neutralization indices were found to be similar for both products: 1.32 for ARILVAX(TM), and 1.26 for YF-VAX(R)(P = 0.1404, by analysis of variance). A similar number of subjects in each group reported at least one adverse event (AE); 441 (59.8%) for ARILVAX(TM) versus 211 (59.9%) for YF-VAX((R)). Most (591- 96.7%) of these were of a mild nature and resolved without treatment. There were no treatment-related serious AEs. This is the first randomized, double-blind comparison of two YF vaccines in a pediatric population-, both vaccines were shown to be highly immunogenic and well-tolerated. C1 USN, Med Res Ctr Detachment, Lima, Peru. Sutter Inst Med Res, Sacramento, CA USA. Walter Reed Army Inst Res, Div Retrovirol & Commun Dis, Washington, DC USA. Walter Reed Army Inst Res, Div Immunol, Washington, DC USA. Acambis Res Ltd, Cambridge, England. Minist Hlth, Sullana, Peru. Acambis Inc, Cambridge, MA USA. RP Belmusto-Worn, VE (reprint author), USN, Med Res Ctr Detachment, Amer Embassy Lima Unit 3800,APO AA 34031-3800, Lima, Peru. EM worn@nmrcd.med.navy.mil; jsanchez@hivresearch.org; karen.mccarthy@acambis.com; rick.nichols@acambis.com; cbautista@nmrcd.med.navy.mil; Alan.Magill@na.amedd.army.mil; 14742@upch.edu.pe; 06082@upch.edu.pe; alaguna@nmrcd.med.navv.mil; bikusa@hotmail.com; mebe4@latinmail.com; james.burans@det.amedd.armv.mil; olson@nmrcd.med.navy.mil; philip.bedford@acambis.com; scott.kitchener@tropmed.org; monath@acambis.com RI Bautista, Christian/B-2812-2011; Kitchener, Scott/M-1885-2013 OI Kitchener, Scott/0000-0002-2656-7588 NR 27 TC 33 Z9 33 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2005 VL 72 IS 2 BP 189 EP 197 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 903CE UT WOS:000227402200014 PM 15741556 ER PT J AU Harrington, LC Scott, TW Lerdthusnee, K Coleman, RC Costero, A Clark, GG Jones, JJ Kitthawee, S Kittayapong, P Sithiprasasna, R Edman, JD AF Harrington, LC Scott, TW Lerdthusnee, K Coleman, RC Costero, A Clark, GG Jones, JJ Kitthawee, S Kittayapong, P Sithiprasasna, R Edman, JD TI Dispersal of the dengue vector Aedes aegypti within and between rural communities SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MARK-RELEASE-RECAPTURE; PUERTO-RICO; DIPTERA-CULICIDAE; STICKY OVITRAPS; POPULATION-SIZE; VILLAGE; MOVEMENT; SURVIVAL; THAILAND; BLOOD AB Knowledge of mosquito dispersal is critical for vector-borne disease control and prevention strategies and for understanding population structure and pathogen dissemination. We determined Aedes aegypti flight range and dispersal patterns from 21 mark-release-recapture experiments conducted over 11 years (1991-2002) in Puerto Rico and Thailand. Dispersal was compared by release location, sex, age, season, and village. For all experiments, the majority of mosquitoes were collected from their release house or adjacent house. Inter-village movement was detected rarely, with a few mosquitoes moving a maximum of 512 meters from one Thai village to the next. Average dispersal distances were similar for males and females and females released indoors versus outdoors. The movement of Ae. aegypti was not influenced by season or age, but differed by village. Results demonstrate that adult Ae. aegypti disperse relatively short distances. suggesting that people rather than mosquitoes are the primary mode of dengue virus dissemination within and among communities. C1 Cornell Univ, Dept Entomol, Ithaca, NY 14850 USA. Univ Calif Davis, Dept Entomol, Davis, CA USA. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand. NIAID, Entomol Sect, Parasit Dis Lab, NIH, Bethesda, MD USA. Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR USA. Mahidol Univ, Fac Sci, Dept Biol, Bangkok, Thailand. Mahidol Univ, Ctr Vectors & Vector Borne Dis, Bangkok, Thailand. RP Harrington, LC (reprint author), Cornell Univ, Dept Entomol, Ithaca, NY 14850 USA. EM lch27@cornell.edu; twscott@ucdqavis.edu; Colemanre@amedd.army.mil; acostero@niaid.hih.gov; ggc1@cdc.gov; james.jones@afrims.org; grskt@mucc.mahidol.ac.th; grpkt@mucc.mahidol.ac.th; ratanas@afrims.org; jdedman@ucdavis.edu FU NIAID NIH HHS [AI-22119] NR 36 TC 241 Z9 246 U1 3 U2 37 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2005 VL 72 IS 2 BP 209 EP 220 PG 12 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 903CE UT WOS:000227402200017 PM 15741559 ER PT J AU Klote, MM Nelson, MR Engler, RJM AF Klote, MM Nelson, MR Engler, RJM TI Autoimmune urticaria response to highdose intravenous immunoglobulin SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Letter C1 Walter Reed Army Med Ctr, Allergy Immunol Dept, Washington, DC 20307 USA. RP Klote, MM (reprint author), Walter Reed Army Med Ctr, Allergy Immunol Dept, Washington, DC 20307 USA. NR 6 TC 14 Z9 15 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD FEB PY 2005 VL 94 IS 2 BP 307 EP 308 PG 2 WC Allergy; Immunology SC Allergy; Immunology GA 900OH UT WOS:000227223700019 PM 15765750 ER PT J AU Zhu, KM Caulfield, J Hunter, S Roland, CL Payne-Wilks, K Texter, L AF Zhu, KM Caulfield, J Hunter, S Roland, CL Payne-Wilks, K Texter, L TI Body mass index and breast cancer risk in African American women SO ANNALS OF EPIDEMIOLOGY LA English DT Article DE African American; breast cancer; case-control study; epidemiology ID NUTRITION EXAMINATION SURVEY; SELF-REPORTED HEIGHT; 3RD NATIONAL-HEALTH; UNITED-STATES; US ADULTS; WEIGHT CHANGE; WHITE WOMEN; BLACK-WOMEN; OBESITY; SIZE AB PURPOSE: Studies of the relationship between body mass index (BMI) and breast cancer in African American women have been few. We conducted a case-control study to examine whether BMI is associated with risk of breast cancer in this population. METHODS: Cases were 304 women diagnosed with breast cancer at the ages of 20 to 64 years. Controls were 305 women without a history of breast cancer. Telephone interviews were conducted to collect data on history of exposure to various factors at or before the date of diagnosis in cases or equivalent date in controls (reference date). Using logistic regression, we compared cases and controls in BMI at age 18, BMI at the reference date, and change in BMI between the two dates. RESULTS: Using BMI at reference date, we found an odds ratio (OR) of 1.75 (95% confidence interval [CI], 1.02-3.02) and 2.32 (95% CI, 1.33-4.03) for women with BMI of 25 to 29.9 and 30 or higher, respectively, compared with women having BMI lower than 25. The corresponding OR estimates for BMI at age 18 were not significantly different from the unity. The average annual change in BMI between age 18 and date of diagnosis or reference date was associated with breast cancer risk, as shown that more BMI change tended to increase breast cancer risk compared with the baseline quartile of change. When data were analyzed by menopausal status, the association was found for both post-menopausal and premenopausal tumors for BMI at reference date but not for BMI at age 18. There was a higher risk for more annual BMI change compared with the baseline for both pre-menopausal and post-menopausal women. CONCLUSION: Our results suggest that BMI at reference date and change in BMI were associated with increased risk of breast cancer in African American women, and the association might be found for both post-menopausal and pre-menopausal tumors. (C) 2004 Elsevier Inc. All rights reserved. C1 Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Hlth Evaluat Sci, Hershey, PA 17033 USA. Meharry Med Coll, Dept Occupat & Prevent Med, Nashville, TN 37208 USA. RP Zhu, KM (reprint author), Walter Reed Army Med Ctr, US Mil Canc Inst, Bldg 1,Suite A109,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM kangmin.zhu@na.amedd.army.mil NR 44 TC 34 Z9 35 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD FEB PY 2005 VL 15 IS 2 BP 123 EP 128 DI 10.1016/j.annepidem.2004.05.011 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 894IR UT WOS:000226785100006 PM 15652717 ER PT J AU Battiata, AP Casler, J AF Battiata, AP Casler, J TI Sclerosing epithelioid fibrosarcoma: A case report SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE head and neck sarcoma; sclerosing epithelioid fibrosarcoma AB Sclerosing epithelioid fibrosarcoma (SEF) is a rare variant of fibrosarcoma. It is a mesenchymal neoplasm composed of round to oval cells dispersed in a nestlike or cordlike distribution on a highly collagenous tissue background and is now recognized as a distinct clinical entity. In this report we discuss the presentation, diagnosis, and treatment of SEE We focus on the unique histologic and immunohistochemical properties of this lesion. It is essential for both the surgeon and the pathologist to be aware of SEF and include it in the differential diagnosis for atypical head and neck neoplasms. Sclerosing epithelioid fibrosarcoma is a rare neoplasm that is now listed among the low-grade neoplasms that may occur in the head and neck. However, its behavior tends to be typical of more aggressive lesions. An awareness of this characteristic of SEF is essential for clinicians and pathologists alike. C1 Walter Reed Army Med Ctr, Dept Surg, Otolaryngol Head & Neck Surg Serv, Washington, DC 20307 USA. RP Battiata, AP (reprint author), Walter Reed Army Med Ctr, Dept Surg, Otolaryngol Head & Neck Surg Serv, Washington, DC 20307 USA. NR 4 TC 5 Z9 10 U1 0 U2 1 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD FEB PY 2005 VL 114 IS 2 BP 87 EP 89 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 897HB UT WOS:000226993500001 PM 15757185 ER PT J AU Kassebaum, PJ Shaw, DL Tomich, DJ AF Kassebaum, PJ Shaw, DL Tomich, DJ TI Possible warfarin interaction with menthol cough drops SO ANNALS OF PHARMACOTHERAPY LA English DT Article DE cough drop; menthol; warfarin ID PEPPERMINT OIL; IN-VITRO; LIVER; RATS AB OBJECTIVE: To report a case of possible interaction of menthol cough drops (Halls) with warfarin in a patient awaiting cardioversion. CASE SUMMARY: A 57-year-old white male awaiting cardioversion for atrial fibrillation was prescribed warfarin. His dosage was adjusted to 7 mg daily to provide stable international normalized ratio (INR) values of 2.28-2.68. Approximately one week later, his INR fell to 1.45. During a follow-up interview, the patient reported that he experienced a flu-like illness during the previous week and had been using menthol cough drops. No other potential causes for the decreased INR were found. Illness will most often elevate the INR; we therefore concluded that the cough drops were the likely cause of this reaction, and the warfarin dose was increased to 53 mg/wk. After discontinuing use of menthol cough drops, the warfarin dose was returned to the previous amount and the INR remained stabilized. DISCUSSION: An objective causality assessment suggests that the decreased INR was possibly related to the use of menthol cough drops during warfarin therapy. The active ingredient in these cough drops is menthol. Menthol has been shown to affect the pharmacokinetics of other drugs by inducing or inhibiting cytochrome P450 isoenzymes and slowing drug absorption. It is not clear whether these mechanisms played a role in this case. As of January 5, 2005 this is the first case report documenting an interaction between warfarin and cough drops containing menthol. CONCLUSIONS: This case documents a significant decrease in the INR following the use of menthol cough drops. Patients who are ill have several factors that can potentially affect their INR and should be monitored closely. C1 Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Kassebaum, PJ (reprint author), Eisenhower Army Med Ctr, Bldg 300, Ft Gordon, GA 30905 USA. EM paul.kassebaum@us.army.mil NR 9 TC 7 Z9 7 U1 1 U2 1 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 USA SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD FEB PY 2005 VL 39 IS 2 BP 365 EP 367 DI 10.1345/aph.1E537 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 891BN UT WOS:000226556400022 PM 15644472 ER PT J AU Stojadinovic, A Fields, SI Shriver, CD Lenington, S Ginor, R Peoples, GE Burch, HB Peretz, T Freund, HR Nissan, A AF Stojadinovic, A Fields, SI Shriver, CD Lenington, S Ginor, R Peoples, GE Burch, HB Peretz, T Freund, HR Nissan, A TI Electrical impedance scanning of thyroid nodules before thyroid surgery: A prospective study SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article DE electrical impedance scanning; thyroid nodule; conductivity; impedance ID FINE-NEEDLE-ASPIRATION; FROZEN-SECTION ANALYSIS; BREAST-CANCER DETECTION; FOLLICULAR NEOPLASMS; BIOPSY; MALIGNANCY; MANAGEMENT; CYTOLOGY; LESIONS; ULTRASOUND AB Background: Electrical impedance scanning (EIS) is a novel imaging technique based on differential electrical conductivity and capacitance of malignant and normal human tissues. The aim of this study was to evaluate the accuracy of EIS in the detection of thyroid malignancies. Methods: Patients with thyroid nodules scheduled for thyroid surgery were eligible for the study. Enrolled patients underwent EIS with a T-Scan 2000ED. Nodule location, size, and type (cystic vs. solid) measured by ultrasound, cytology results, thyroid conductivity, and capacitance calculated by EIS were recorded. EIS results were interpreted as positive or negative for malignancy and compared with final histopathology results. Study end points included EIS accuracy, sensitivity, specificity, negative and positive predictive values, and false-positive and false-negative rates. Results: Sixty-four patients were enrolled onto the study, and all underwent either lobectomy-isthmusectomy (20%) or total thyroidectomy (80%). The mean tumor diameter was 2.64 +/- 14.8 mm. Thyroid cancers were identified by histology in 30 patients (46.9%). There were I I false-positive and four false-negative cases. The overall diagnostic accuracy of EIS was 76.6% (49 of 64 correct diagnoses). The sensitivity and specificity of EIS were 86.7% (26 of 30 true positive) and 67.6% (23 of 34 true negative), respectively. The corresponding positive and negative predictive values were 70.3% and 85.2%. Conclusions: EIS is a potentially useful imaging modality for differentiating thyroid neoplasms. If these results are confirmed in large-scale trials, EIS may be an important part of the evaluation of thyroid nodules. C1 Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, Washington, DC 20307 USA. Hadassah Univ Hosp, Dept Radiol, IL-91240 Jerusalem, Israel. Mirabel Med, Austin, TX 78759 USA. Hadassah Univ Hosp, Dept Oncol, IL-91240 Jerusalem, Israel. Hadassah Univ Hosp, Dept Surg, IL-91240 Jerusalem, Israel. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM alexander.stojadinovic@na.amedd.army.mil NR 34 TC 8 Z9 8 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2005 VL 12 IS 2 BP 152 EP 160 DI 10.1245/ASO.2005.03.062 PG 9 WC Oncology; Surgery SC Oncology; Surgery GA 898TJ UT WOS:000227098800013 PM 15827796 ER PT J AU Berger, AC Le Voyer, T Hanlon, A Sigurdson, E AF Berger, AC Le Voyer, T Hanlon, A Sigurdson, E TI Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes (LN ratio) SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 58th Annual Cancer Symposium CY MAR 03-06, 2005 CL Atlanta, GA SP Soc Surg Oncol C1 Thomas Jefferson Univ, Philadelphia, PA 19107 USA. Fox Chase Canc Ctr, Philadelphia, PA 19111 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2005 VL 12 IS 2 SU S BP S31 EP S31 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 895FU UT WOS:000226847100076 ER PT J AU Dehqanzada, ZA Storrer, CE Hueman, MT Foley, R Harris, K Jama, Y Shriver, CD Ponniah, S Peoples, GE AF Dehqanzada, ZA Storrer, CE Hueman, MT Foley, R Harris, K Jama, Y Shriver, CD Ponniah, S Peoples, GE TI Assessing serum cytokine profiles in breast cancer patients receiving a HER2/neu vaccine using Luminex (R) technology SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 58th Annual Cancer Symposium CY MAR 03-06, 2005 CL Atlanta, GA SP Soc Surg Oncol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Clin Breast Care Project, Immunol Res Ctr, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2005 VL 12 IS 2 SU S BP S47 EP S48 PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 895FU UT WOS:000226847100123 ER PT J AU Ellsworth, R Ellsworth, DL Deyarmin, B Hoffman, LR Hooke, JA Shriver, CD AF Ellsworth, R Ellsworth, DL Deyarmin, B Hoffman, LR Hooke, JA Shriver, CD TI Timing of critical genetic changes in human breast disease SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 58th Annual Cancer Symposium CY MAR 03-06, 2005 CL Atlanta, GA SP Soc Surg Oncol C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2005 VL 12 IS 2 SU S BP S16 EP S16 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 895FU UT WOS:000226847100027 ER PT J AU Hueman, MT Stojadinovic, A Gurney, JM Dehqanzada, Z Storrer, CE Shriver, CD Ponniah, S Peoples, GF AF Hueman, MT Stojadinovic, A Gurney, JM Dehqanzada, Z Storrer, CE Shriver, CD Ponniah, S Peoples, GF TI Levels of circulating regulatory CD4+CD25+T cells decreased in breast cancer patients after vaccination with a HER2/neu (E75) peptide SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 58th Annual Cancer Symposium CY MAR 03-06, 2005 CL Atlanta, GA SP Soc Surg Oncol C1 Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Clin Breast Care Project, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2005 VL 12 IS 2 SU S BP S52 EP S53 PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 895FU UT WOS:000226847100137 ER PT J AU Mittendorf, EA Storrer, CE Shriver, CD Ponniah, S Peoples, GE AF Mittendorf, EA Storrer, CE Shriver, CD Ponniah, S Peoples, GE TI Investigation of a combination of trastuzumab and HER2 peptide vaccines for the treatment of breast cancer SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 58th Annual Cancer Symposium CY MAR 03-06, 2005 CL Atlanta, GA SP Soc Surg Oncol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Clin Breast Care Project, Immunol Res Ctr, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2005 VL 12 IS 2 SU S BP S34 EP S34 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 895FU UT WOS:000226847100087 ER PT J AU Cardello, AV Schutz, HG Lesher, LL Merrill, E AF Cardello, AV Schutz, HG Lesher, LL Merrill, E TI Development and testing of a labeled magnitude scale of perceived satiety SO APPETITE LA English DT Review DE satiety; hunger; fullness; scaling; labeled magnitude scales ID FOOD-INTAKE; GENETIC-VARIATION; APPETITE RATINGS; ENERGY-INTAKE; FAT-CONTENT; TASTE; SENSATIONS; PRELOADS; VALIDITY; PSYCHOPHYSICS AB Satiety ratings are often made using VAS or simple category scales. In order to establish a simple, more quantitative technique to index perceived hunger and/or fullness, research was undertaken to develop and test a labeled magnitude scale of satiety. Thirty-seven subjects rated the semantic meaning of 47 phrases describing different levels of hunger/fullness using magnitude estimation. Eleven phrases were then selected using criteria of response consistency, symmetry, bipolarity, and inclusion of the end-point anchors of 'greatest imaginable hunger (fullness)'. These phrases were placed along a vertical line scale at positions corresponding to their geometric mean magnitude estimates to create a labeled magnitude scale of satiety. This Satiety Labeled Intensity Magnitude (SLIM) scale was compared to VAS scales for sensitivity and reliability in two studies. In one image-based study, ANOVA with post-hoc tests showed the SLIM scale to have greater sensitivity and to have an average reliability coefficient of 0.90. In a second study using three different foods replicated on two consecutive weeks, reliability was found to be highest for the SLIM scale. It is concluded that the SLIM scale is a sensitive, reliable, and easy-to-use scale for measuring perceived satiety that has several advantages over other, more commonly used satiety scales. (C) 2004 Elsevier Ltd. All rights reserved. C1 US Army Natick Soldier Ctr, Sci & Technol Directorate, Natick, MA 01760 USA. Univ Calif Davis, Consumer Sci Dept, Davis, CA 95616 USA. Geocenters Inc, Natick, MA 01760 USA. RP Cardello, AV (reprint author), US Army Natick Soldier Ctr, Sci & Technol Directorate, Natick, MA 01760 USA. EM armand.cardello@natick.arrny.mil NR 57 TC 55 Z9 57 U1 4 U2 14 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 J9 APPETITE JI Appetite PD FEB PY 2005 VL 44 IS 1 BP 1 EP 13 DI 10.1016/j.appet.2004.05.007 PG 13 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA 893YZ UT WOS:000226758300001 PM 15604029 ER PT J AU de Graaf, C Cardello, AV Kramer, FM Lesher, LL Meiselman, HL Schutz, HG AF de Graaf, C Cardello, AV Kramer, FM Lesher, LL Meiselman, HL Schutz, HG TI A comparison between liking ratings obtained under laboratory and field conditions: the role of choice SO APPETITE LA English DT Review DE sensory; preference; hedonic ratings; validity; laboratory setting; real life setting ID FOOD ACCEPTANCE; VARIETY AB The relationship between laboratory and field data was investigated for nine different groupings of 5-7 foods: two main dish groupings, four snack item groupings, and three specific meals. Liking ratings on the nine-point hedonic scale were obtained in an US Army field study and for the same foods in a sensory laboratory. In a subsequent choice simulation laboratory with two food groupings, we offered subjects some choice (three out of six or seven items) among to which foods they would evaluate. The results showed high correlations between lab and field ratings for the snack food groupings (0.58-0.94), but low correlations for the main dishes (-0.05-0.26) and meal components (- 0.07-0.41). Correlations between mean field and mean laboratory data improved when laboratory subjects were offered a choice of foods. The ability of laboratory ratings to predict acceptability of foods consumed under realistic conditions appears to depend on the type of food, and may be better for foods used as snacks than for main dishes. Laboratory conditions in which subjects had some degree of choice among foods improved the relationship with the field data. It is important to pay more attention to experimental variables that may improve the validity of sensory laboratory tests. (C) 2004 Elsevier Ltd. All rights reserved. C1 Wageningen Univ, Dept Human Nutr, NL-6700 EV Wageningen, Netherlands. US Army Natick Res Dev & Engn Ctr, Behav Sci Div, Sci & Technol Directorate, Natick, MA USA. RP de Graaf, C (reprint author), Wageningen Univ, Dept Human Nutr, NL-6700 EV Wageningen, Netherlands. EM Kees.deGraaf@wur.nl NR 16 TC 42 Z9 42 U1 0 U2 9 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 J9 APPETITE JI Appetite PD FEB PY 2005 VL 44 IS 1 BP 15 EP 22 DI 10.1016/j.appet.2003.06.002 PG 8 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA 893YZ UT WOS:000226758300002 PM 15604030 ER PT J AU de Graaf, C Kramer, FM Meiselman, HL Lesher, LL Baker-Fulco, C Hirsch, ES Warber, J AF de Graaf, C Kramer, FM Meiselman, HL Lesher, LL Baker-Fulco, C Hirsch, ES Warber, J TI Food acceptability in field studies with US army men and women: relationship with food intake and food choice after repeated exposures SO APPETITE LA English DT Review DE sensory; preference; hedonic ratings; intake; choice; reliability; validity ID PALATABILITY; CONSUMPTION; PREFERENCES; HUMANS; MEAL; ACCEPTANCE; RESPONSES; RATINGS; PLEASANTNESS; DEPRIVATION AB Laboratory data with single exposures showed that palatability has a positive relationship with food intake. The question addressed in this study is whether this relationship also holds over repeated exposures in non-laboratory contexts in more natural environments. The data were collected in four field studies, lasting 4-11 days with 307 US Army men and 119 Army women, and comprised 5791 main meals and 8831 snacks in total. Acceptability was rated on the nine point hedonic scale, and intake was registered in units of 1/4, 1/2, 3/4, or I or more times of the provided portion size. Correlation coefficients between individual acceptability ratings and intakes varied from 0.22 to 0.62 for the main meals (n = 193-2267), and between 0.13 and 0.56 for the snacks (it = 304-2967). The likelihood of choosing a meal for the second time was positively related to the acceptability rating of the meal when it was consumed for the first time. The results reinforce the importance of liking in food choice and food intake/choice behavior. However, the magnitude of the correlation coefficients between acceptability ratings and food intake suggest that environmental factors also have an important role in determining intake and choice. (C) 2004 Elsevier Ltd. All rights reserved. C1 Wageningen Univ, Div Human Nutr, NL-6700 EV Wageningen, Netherlands. USA, Natrick Res Dev & Engn Ctr, Behav Sci Div, Sci & Technol Directorate, Natick, MA 01760 USA. Geocenters Inc, Natick, MA 01760 USA. USA, Inst Environm Med, Natick, MA 01760 USA. Texas So Univ, Dept Human Serv & Consumer Sci, Houston, TX 77004 USA. RP de Graaf, C (reprint author), Wageningen Univ, Div Human Nutr, POB 8129, NL-6700 EV Wageningen, Netherlands. EM kees.degaaf@wur.nl NR 33 TC 37 Z9 37 U1 0 U2 3 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 J9 APPETITE JI Appetite PD FEB PY 2005 VL 44 IS 1 BP 23 EP 31 DI 10.1016/j.appet.2004.08.008 PG 9 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA 893YZ UT WOS:000226758300003 PM 15604031 ER PT J AU Hirsch, ES Kramer, FM Meiselman, HL AF Hirsch, ES Kramer, FM Meiselman, HL TI Effects of food attributes and feeding environment on acceptance, consumption and body weight: lessons learned in a twenty-year program of military ration research US Army Research (Part 2) SO APPETITE LA English DT Review DE military rations; food intake; food acceptance; monotony; novelty; portion size; feeding environment ID OPERATIONAL RATIONS; DIETARY VARIETY; MONOTONY; ACCEPTABILITY; SOLDIERS; TEMPERATURE; OVERWEIGHT; BEVERAGES; OBESITY; ENERGY AB Twenty years of testing in the field has consistently revealed that food intake is inadequate when packaged military rations are fed as the sole source of food. Food intake is much lower and there is a loss of body weight. Conversely when these rations are fed to students or military personnel for periods ranging from 3 to 42 days in a cafeteria-like setting, food intake is comparable to levels of a control group provided with freshly prepared food. Under these conditions, body weight is maintained. In this review, the consumption pattern is considered in terms of characteristics of the food (acceptability, variety, portion size, beverages, serving temperature, appropriateness for time of day, monotony, and novelty) and the eating milieu (social interactions, time, ease of preparing and consuming a meal). The twenty-year program of military ration research has led us to conclude that both the food and the context must be considered in understanding and controlling food intake. Published by Elsevier Ltd. C1 USA, Natick Soldier Ctr, Natick, MA 01760 USA. RP Hirsch, ES (reprint author), USA, Natick Soldier Ctr, Natick, MA 01760 USA. EM edward.hirsch@natick.army.mil NR 46 TC 20 Z9 22 U1 3 U2 12 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 J9 APPETITE JI Appetite PD FEB PY 2005 VL 44 IS 1 BP 33 EP 45 DI 10.1016/j.appet.2004.04.010 PG 13 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA 893YZ UT WOS:000226758300004 PM 15604032 ER PT J AU Tharion, WJ Lieberman, HR Montain, SJ Young, AJ Baker-Fulco, CJ DeLany, JP Hoyt, RW AF Tharion, WJ Lieberman, HR Montain, SJ Young, AJ Baker-Fulco, CJ DeLany, JP Hoyt, RW TI Energy requirements of military personnel SO APPETITE LA English DT Review DE doubly labeled water; environment; exercise; military feeding; military training; nutrition; soldiers ID DOUBLY-LABELED WATER; SPECIAL-FORCES SOLDIERS; EXPENDITURES TDEES; FOOD RATIONS; BODY WATER; FIELD; EXERCISE; BALANCE; ADEQUACY; HUMANS AB Energy requirements of military personnel (Soldiers, Sailors, Airmen, and Marines) have been measured in garrison and in field training under a variety of climatic conditions. Group mean total energy expenditures for 424 male military personnel from various units engaged in diverse missions ranged from 13.0 to 29.8 MJ (3109-7131 kcal) per day. The overall mean was 19.3 +/- 2.7 MJ (mean +/- SD) (4610 +/- 650 kcal) per day measured over an average of 12.2 days (range 2.25-69 days). For the 77 female military personnel studied, mean total energy expenditures for individual experimental groups ranged from 9.8 to 23.4 MJ (2332-5597 kcal) per day, with an overall mean of 11.9 +/- 2.6 MJ (2850 +/- 620 kcal) per day, measured over an average of 8.8 days (range 2.25-14 days). Women, presumably due to their lower lean body mass, resting metabolic rate, and absolute work rates, had lower total energy expenditures. Combat training produced higher energy requirements than non-combat training or support activities. Compared to temperate conditions, total energy expenditures did not appear to be influenced by hot weather, but tended to be higher in the cold or high altitude conditions. (C) 2004 Elsevier Ltd. All rights reserved. C1 USA, Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. RP Tharion, WJ (reprint author), USA, Res Inst Environm Med, Mil Nutr Div, Kansas St, Natick, MA 01760 USA. EM william.tharion@na.amedd.army.mil NR 82 TC 55 Z9 57 U1 1 U2 14 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 J9 APPETITE JI Appetite PD FEB PY 2005 VL 44 IS 1 BP 47 EP 65 DI 10.1016/j.appet.2003.11.010 PG 19 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA 893YZ UT WOS:000226758300005 PM 15604033 ER PT J AU Kandidov, VP Akozbek, N Scalora, M Kosareva, OG Nyakk, AV Luo, Q Hosseini, SA Chin, SL AF Kandidov, VP Akozbek, N Scalora, M Kosareva, OG Nyakk, AV Luo, Q Hosseini, SA Chin, SL TI Towards a control of multiple filamentation by spatial regularization of a high-power femtosecond laser pulse SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID WHITE-LIGHT CONTINUUM; CONDENSED MEDIA; AIR; PROPAGATION; SIMULATIONS; GASES AB We propose a new method for controlling randomly generated multiple filaments during the propagation of femtosecond laser pulses in optical media. The method is based on introducing a periodic amplitude modulation of the transverse beam profile. It is shown both experimentally and numerically that the introduction of a periodic mesh into a propagation path of a femtosecond near-infrared laser pulse leads to a deterministic spatial distribution of multiple filaments in the presence of initial random fluctuations. As a result, the number of filaments is increased as compared to the random case. C1 Moscow MV Lomonosov State Univ, Dept Phys, Ctr Int Laser, Moscow 119992, Russia. Time Domain Corp, Huntsville, AL 35806 USA. USA, Aviat & Missile Command, AMSAM WS RD ST, Redstone Arsenal, AL 35898 USA. Univ Laval, Dept Phys Genie Phys & Opt, Quebec City, PQ G1K 7P4, Canada. Univ Laval, Ctr Opt Photon & Laser, Quebec City, PQ G1K 7P4, Canada. RP Kosareva, OG (reprint author), Moscow MV Lomonosov State Univ, Dept Phys, Ctr Int Laser, Moscow 119992, Russia. EM kosareva@msuilc.phys.msu.su NR 24 TC 60 Z9 60 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD FEB PY 2005 VL 80 IS 2 BP 267 EP 275 DI 10.1007/s00340-004-1677-1 PG 9 WC Optics; Physics, Applied SC Optics; Physics GA 887QN UT WOS:000226320700022 ER PT J AU Bojescul, JA Wilson, G Taylor, DC AF Bojescul, JA Wilson, G Taylor, DC TI Idiopathic chondrolysis of the ankle SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY LA English DT Article DE chondrolysis; ankle; arthroscopy; idiopathic ID HIP AB A 21-year-old West Point cadet presented to our institution with a history of chronic left lateral ankle instability. The initial injury occurred 5 years earlier. Physical examination results and stress radiographs were consistent with lateral instability. The patient underwent an ankle arthroscopy and lateral ankle ligament reconstruction. Arthroscopic findings included moderate synovitis, grade II anterolateral chondrosis, and an anterior talar osteophyte. The patient had an uneventful postoperative course and returned to activity. Eleven months after surgery he presented with increased left ankle pain. On physical examination he had a stable ankle, but radiographs revealed marked loss of ankle joint space. Significant diffuse fraying and thinning of the articular cartilage noted on repeat arthroscopy were consistent with chondrolysis. C1 Keller Army Community Hosp, Orthopaed Surg Serv, W Point, NY USA. RP Taylor, DC (reprint author), Keller Army Community Hosp, Orthopaed Surg Serv, Bldg 900,Washington Rd, W Point, NY USA. EM dean.taylor@na.amedd.army.mil NR 9 TC 25 Z9 25 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD FEB PY 2005 VL 21 IS 2 BP 224 EP 227 DI 10.1016/j.arthro.2004.10.006 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 902KE UT WOS:000227353700014 PM 15689873 ER PT J AU LaJambe, CM Kamimori, GH Belenky, G Balkin, TJ AF LaJambe, CM Kamimori, GH Belenky, G Balkin, TJ TI Caffeine effects on recovery sleep following 27 h total sleep deprivation SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE psychomotor vigilance; habitual use; polysomnography; slow wave sleep ID PERFORMANCE; COFFEE; EEG; DISTURBANCES; AMPHETAMINE; INSOMNIA; MODEL AB Caffeine is widely used to reverse alertness and performance decrements. However, caffeine's effects on subsequent recovery sleep and post-recovery performance are not well documented and, therefore, were evaluated. Methods: Six habitually low (LC: less than or equal to 100 mg. d(-1)) and three habitually high (HC: greater than or equal to 400 mg (.) d(-1)) caffeine users completed a randomized crossover design. After 20 h of wakefulness, repeated doses of caffeine gum [0 (placebo) mg, 100 (low dose) mg, or 300 (high dose) mg] were administered at 03:00, 05:00, and 07:00. At 70:00 (27 h sleep deprivation) subjects slept for 8 h, followed by Psychomotor Vigilance Task (PVT) administration at 33 and 65 min post-awakening. Results: Low dose caffeine increased stage I minutes only. However, high dose caffeine impaired sleep maintenance (reduced total sleep time/increased wake) and reduced sleep depth (increased stage 1 minutes/percentage and slow-wave sleep (SWS) latency, and reduced SWS minutes during the first third of the sleep period). With high dose caffeine, LC users had less SWS percentage as compared with HC users. The HC users had reduced stage 2 percentage with high dose caffeine as compared with placebo and low dose caffeine. Caffeine dose and habitual caffeine use did not influence post-recovery sleep PVT performance. Discussion: Caffeine exerts mild deleterious dose-response effects on recovery sleep following total sleep deprivation, primarily early in the sleep period, with potential recovery from these effects after sufficient sleep as suggested by lack of post-recovery sleep performance deficits. Habitual caffeine use appears to minimally reduce caffeine effects. C1 Walter Reed Army Inst Res, Dept Behav Biol, Div Neurosci, Silver Spring, MD USA. RP LaJambe, CM (reprint author), Penn State Univ, Penn Transportat Inst, 201 Transportat Res Bldg, University Pk, PA 16802 USA. EM CML149@psu.edu NR 25 TC 22 Z9 22 U1 0 U2 11 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 2005 VL 76 IS 2 BP 108 EP 113 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 893FS UT WOS:000226705300005 PM 15742825 ER PT J AU Seaman, RL Phelix, CF AF Seaman, RL Phelix, CF TI Acute effects of pulsed microwaves and 3-nitropropionic acid on neuronal ultrastructure in the rat caudate-putarnen SO BIOELECTROMAGNETICS LA English DT Review DE chemical hypoxia; stereology; endoplasmic reticulum; nuclear envelope; mitochondria; striatum ID BLOOD-BRAIN-BARRIER; INDUCED IN-VIVO; SELECTIVE STRIATAL DEGENERATION; MAGNETIC-RESONANCE-SPECTROSCOPY; CENTRAL-NERVOUS-SYSTEM; HUNTINGTONS-DISEASE; MITOCHONDRIAL TOXIN; ENDOPLASMIC-RETICULUM; METABOLIC COMPROMISE; ENERGY-METABOLISM AB Ultrastructure of the medium sized "spiny" neuron in rat dorsal-lateral caudate-putamen was assessed after administration of 3-nitropropionic acid (3-NP) and exposure to pulsed microwaves. Sprague-Dawley male rats were given two daily intraperitoneal doses of 0 or 10 mg/kg 3-NP and 1.5 h after each dose were exposed to microwave radiation at a whole body averaged specific absorption rate (SAR) of 0 (sham exposure), 0.6, or 6 W/kg for 30 min. Microwave exposure consisted of 1.25 GHz radiation delivered as 5.9 mus pulses with repetition frequency 10 Hz. Tissue samples taken 2-3 h after the second sham or microwave exposure showed no injury with light microscope methods. Blinded qualitative assessment of ultrastructure of randomly selected neurons from the same samples did reveal differences. Subsequent detailed, quantitative measurements showed that, when followed by sham exposure, administration of 3-NP significantly increased endoplasmic reticulum (ER) intracisternal width, ER area density, and nuclear envelope thickness. Microwave exposure at 6 W/kg alone also significantly increased these measures. Exposure of 3-NP treated animals at 6 W/kg significantly increased effects of 3-NP on ultrastructure. Although exposure at 0.6 W/kg alone did not affect ultrastructure measures, exposure of 3-NP treated animals at 0.6 W/kg reduced the effects of 3-NP. We concluded that 3-NP changed neuronal ultrastructure and that the microwave exposures used here changed neuronal ultrastructure in ways that depended on microwave SAR and neuron metabolic status. The apparent cancellation of 3-NP induced changes by exposure to pulsed microwaves at 0.6 W/kg indicated the possibility that such exposure can protect against the effects of mitochondrial toxins on the nervous system. Published 2005 Wiley-Liss, Inc(dagger). C1 USA, Med Res Detachment, McKesson BioServ Corp, Brooks AFB, TX 78235 USA. USA, Med Res Detachment, Microwave Bioeffects Branch, Brooks AFB, TX 78235 USA. Univ Texas, Dept Biol, San Antonio, TX 78285 USA. RP Seaman, RL (reprint author), USA, Med Res Detachment, McKesson BioServ Corp, 8355 Hawks Rd,Bldg 1168, Brooks AFB, TX 78235 USA. EM ronald.seaman@brooks.af.mil RI Phelix, Clyde/L-8048-2015 OI Phelix, Clyde/0000-0002-6703-514X NR 130 TC 4 Z9 4 U1 1 U2 6 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0197-8462 J9 BIOELECTROMAGNETICS JI Bioelectromagnetics PD FEB PY 2005 VL 26 IS 2 BP 82 EP 101 DI 10.1002/bem.20054 PG 20 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA 892UT UT WOS:000226676200004 PM 15672367 ER PT J AU Donohue, T Gorak, E McGettigan, C Morgan, T Fadell, A Srinivasan, R Childs, R AF Donohue, T Gorak, E McGettigan, C Morgan, T Fadell, A Srinivasan, R Childs, R TI Significant decline in pulmonary engraftment syndrome after nonmyeloablative allogeneic hematopoietic cell transplantation associated with less amphotericin use for febrile neutropenia SO BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION LA English DT Meeting Abstract CT Joint Meeting of the American-Society-for-Blood-and-Marrow-Transplantation/Center-for-Interna tional-Blood-and-Marrow-Transplant-Research CY FEB 10-14, 2005 CL Keystone, CO SP Amer Soc Blood Marrow Transplantation, Ctr Int Blood Marrow Transplantation C1 NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CARDEN JENNINGS PUBL CO LTD PI CHARLOTTESVILLE PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903 USA SN 1083-8791 J9 BIOL BLOOD MARROW TR JI Biol. Blood Marrow Transplant. PD FEB PY 2005 VL 11 IS 2 SU 1 MA 115 BP 40 EP 40 DI 10.1016/j.bbmt.2004.12.116 PG 1 WC Hematology; Immunology; Transplantation SC Hematology; Immunology; Transplantation GA 902CM UT WOS:000227329000115 ER PT J AU Guan, J Zhang, Q Montip, G Karle, JM Ditusa, CA Milhous, WK Skillman, DR Lin, AJ AF Guan, J Zhang, Q Montip, G Karle, JM Ditusa, CA Milhous, WK Skillman, DR Lin, AJ TI Structure identification and prophylactic antimalarial efficacy of 2-guanidinoimidazolidinedione derivatives SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE antimalarial; guanidinoimidazolidinediones; carbamates; WR182398 ID TROPHOZOITE-INDUCED INFECTIONS; PRIMAQUINE AB The reported synthetic procedure of WR182393, a 2-guanidinoimidazolidinedione derivative with high prophylactic anti-malarial activity, was found to be a mixture of three closely related products. Poor solubility of WR182393 in both water and organic solvents and its impractical synthetic method have made the purification and structure identification of the reaction mixture a highly challenging task. The problems were circumvented by prodrug approach involving carbamate formation of the mixture. which enhances the solubility of the mixture in common organic solvents and facilitates the separation and structure determination of the two products. The structures of the two components were determined by X-ray crystallography and NMR of their corresponding carbamates 3a and 4a. Additional alkyl carbamates were prepared according to the same approach and two new carbamates 3b and 4d were found to possess higher intramuscular (im) efficacy than the parent compound WR182393 against Plasmodium cynomolgi in Rhesus monkey. (C) 2004 Elsevier Ltd. All rights reserved. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Guan, J (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jian.guan@na.amedd.army.mil RI DiTusa, Charles/A-9143-2011 NR 11 TC 15 Z9 15 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD FEB 1 PY 2005 VL 13 IS 3 BP 699 EP 704 DI 10.1016/j.bmc.2004.10.052 PG 6 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 892UZ UT WOS:000226676800012 PM 15653337 ER PT J AU Andreas, EL Jordan, RE Makshtas, AP AF Andreas, EL Jordan, RE Makshtas, AP TI Parameterizing turbulent exchange over sea ice: The Ice Station Weddell results SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE air-sea-ice interaction; eddy-covariance measurements; Ice Station Weddell; roughness lengths; sea ice; turbulent surface. fluxes ID SCALAR TRANSFER-COEFFICIENTS; WATER-VAPOR TRANSFER; DRAG COEFFICIENTS; SONIC ANEMOMETER; EDDY-CORRELATION; HEAT-FLUX; SURFACE-LAYER; SENSIBLE HEAT; WIND STRESS; SNOW AB A 4-month deployment on Ice Station Weddell (ISW) in the western Weddell Sea yielded over 2000 h of nearly continuous surface-level meteorological data, including eddy-covariance measurements of the turbulent surface fluxes of momentum, and sensible and latent heat. Those data lead to a new parameterization for the roughness length for wind speed, z(0), for snow-covered sea ice that combines three regimes: an aerodynamically smooth regime, a high-wind saltation regime, and an intermediate regime between these two extremes where the macroscale or 'permanent' roughness of the snow and ice determines z(0). Roughness lengths for temperature, z(T), computed from this data set corroborate the theoretical model that Andreas published in 1987. Roughness lengths for humidity, z(Q), do not support this model as conclusively but are all, on average, within an order of magnitude of its predictions. Only rarely are z(T) and z(Q) equal to z(0). These parameterizations have implications for models that treat the atmosphere-ice-ocean system. C1 USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Int Arctic Res Ctr, Fairbanks, AK 99775 USA. Arctic & Antarctic Res Inst, St Petersburg 199397, Russia. RP Andreas, EL (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM eandreas@crrel.usace.army.mil NR 69 TC 47 Z9 48 U1 0 U2 10 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD FEB PY 2005 VL 114 IS 2 BP 439 EP 460 DI 10.1007/s10546-004-1414-7 PG 22 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 875RO UT WOS:000225439600007 ER PT J AU Gerry, AC Zhang, X Walker, T Frederickson, S Metzger, M Hu, R Krieger, RI AF Gerry, AC Zhang, X Walker, T Frederickson, S Metzger, M Hu, R Krieger, RI TI Worker exposure to diazinon during flea control operations in response to a plague epizootic SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article C1 Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA. Univ Calif Riverside, Dept Entomol, Personal Chem Exposure Program, Riverside, CA 92521 USA. USA, Calif Dept Hlth Serv, Dis Sect, Ontario, CA 91764 USA. Inyo Cty Environm Hlth Dept, Vector Control Sect, Bishop, CA 93514 USA. RP Gerry, AC (reprint author), Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA. NR 11 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD FEB PY 2005 VL 74 IS 2 BP 391 EP 398 DI 10.1007/s00128-004-0597-4 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 890ZT UT WOS:000226551800025 PM 15841983 ER PT J AU Ohlweiler, JN AF Ohlweiler, JN TI Disability and the major life activity of work: An Un-"work"-able definition SO BUSINESS LAWYER LA English DT Review ID LEGISLATIVE HISTORY; ACT C1 USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Ohlweiler, JN (reprint author), USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. NR 104 TC 1 Z9 1 U1 1 U2 1 PU AMER BAR ASSOC PI CHICAGO PA 750 N LAKE SHORE DR, ATTN:ORDER FULFILLMENT, CHICAGO, IL 60611 USA SN 0007-6899 J9 BUS LAWYER JI Bus. Lawyer PD FEB PY 2005 VL 60 IS 2 BP 577 EP 610 PG 34 WC Law SC Government & Law GA 925MB UT WOS:000229056100008 ER PT J AU Lu, Z Shieh, LS Chen, GR Coleman, NP AF Lu, Z Shieh, LS Chen, GR Coleman, NP TI Simplex sliding mode control for nonlinear uncertain systems via chaos optimization SO CHAOS SOLITONS & FRACTALS LA English DT Article ID VARIABLE-STRUCTURE CONTROL; ATTRACTOR AB As an emerging effective approach to nonlinear robust control, simplex sliding mode control demonstrates some attractive features not possessed by the conventional sliding mode control method, from both theoretical and practical points of view. However, no systematic approach is currently available for computing the simplex control vectors in nonlinear sliding mode control. In this paper, chaos-based optimization is exploited so as to develop a systematic approach to seeking the simplex control vectors; particularly, the flexibility of simplex control is enhanced by making the simplex control vectors dependent on the Euclidean norm of the sliding vector rather than being constant, which result in both reduction of the chattering and speedup of the convergence. Computer simulation on a nonlinear uncertain system is given to illustrate the effectiveness of the proposed control method. (C) 2004 Elsevier Ltd. All rights reserved. C1 Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA. City Univ Hong Kong, Dept Elect Engn, Kowloon, Hong Kong, Peoples R China. USA, Armament Ctr, Dover, NJ 07801 USA. RP Lu, Z (reprint author), Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA. OI Chen, Guanrong/0000-0003-1381-7418 NR 18 TC 30 Z9 34 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-0779 J9 CHAOS SOLITON FRACT JI Chaos Solitons Fractals PD FEB PY 2005 VL 23 IS 3 BP 747 EP 755 DI 10.1016/j.chaos.2004.03.039 PG 9 WC Mathematics, Interdisciplinary Applications; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA 863YT UT WOS:000224600200007 ER PT J AU Lesho, EP Wortmann, G Neafie, R Aronson, N AF Lesho, EP Wortmann, G Neafie, R Aronson, N TI Nonhealing skin lesions in a sailor and a journalist returning from Iraq SO CLEVELAND CLINIC JOURNAL OF MEDICINE LA English DT Editorial Material ID INTRALESIONAL MEGLUMINE ANTIMONIATE; AMERICAN CUTANEOUS LEISHMANIASIS; CONTROLLED CLINICAL-TRIAL; SODIUM STIBOGLUCONATE; EFFICACY; GUATEMALA; DIAGNOSIS; CRYOTHERAPY; SAFETY C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Lesho, EP (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 45 TC 5 Z9 5 U1 0 U2 0 PU CLEVELAND CLINIC PI CLEVELAND PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA SN 0891-1150 J9 CLEV CLIN J MED JI Clevel. Clin. J. Med. PD FEB PY 2005 VL 72 IS 2 BP 93 EP + PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 899QH UT WOS:000227159100004 PM 15757166 ER PT J AU Anderson, J Fleming, SD Rehrig, S Tsokos, GC Basta, M Shea-Donohue, T AF Anderson, J Fleming, SD Rehrig, S Tsokos, GC Basta, M Shea-Donohue, T TI Intravenous immunoglobulin attenuates mesenteric ischemia-reperfusion injury SO CLINICAL IMMUNOLOGY LA English DT Article DE complement; IVIG; ischemia-reperfusion; neutrophil; inflammation; rat ID INTESTINAL ISCHEMIA; ISCHEMIA/REPERFUSION INJURY; CAPILLARY LEAK; COMPLEMENT; RAT; INFLAMMATION; MODULATION; FRAGMENTS; DAMAGE AB Intravenous immunoglobulin (IVIG) has been found useful in the treatment of various clinical entities and its effect has been associated with inhibition of complement-mediated tissue damage. The aim of this study was to determine the ability of IVIG to protect against mesenteric ischemia-reperfusion (IR)-induced local and remote injury. Rats received vehicle or IVIG (150-600 mg/kg) 5 min prior to sham operation or 30 min of superior mesenteric artery occlusion, followed by 5, 120, or 240 min of reperfusion. IVIG reduced IR-induced mucosal injury without altering IR-induced increases in PMN infiltration or LTB4 generation. At 5 min post IR, the deposition of IgG and C3 in the lamina propria and surface epithelial cells was attenuated by IVIG. The increased capillary leak, evident at 240 min, was inhibited by IVIG and coincided with a reduction in C3 deposition in lung tissue. The beneficial effects of IVIG may be related to the ability to scavenge deleterious products. Published by Elsevier Inc. C1 Univ Maryland, Sch Med, Mucosal Biol Res Ctr, Baltimore, MD 21201 USA. Univ Maryland, Dept Med, Baltimore, MD 21201 USA. USDA ARS, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA. NIAID, Clin Invest Lab, NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Dept Cellular Injury, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. MD Inst Res, Dept Surg, Walter Reed Army Forest Glen, Silver Spring, MD 20910 USA. RP Shea-Donohue, T (reprint author), Univ Maryland, Sch Med, Mucosal Biol Res Ctr, 20 Penn St,HSF 2,Room 349, Baltimore, MD 21201 USA. EM tdonohue@medicine.umaryland.edu OI rehrig, scott/0000-0002-1287-9708; Basta, Milan/0000-0001-5958-9241 NR 29 TC 14 Z9 14 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD FEB PY 2005 VL 114 IS 2 BP 137 EP 146 DI 10.1016/j.clim.2004.08.018 PG 10 WC Immunology SC Immunology GA 889KA UT WOS:000226440700006 PM 15639647 ER PT J AU Barker, TL Gettayacamin, M Hansukjariya, P Van Gessel, Y Melendez, V Teja-Isavadharm, P Vennerstrom, J Miller, RS Ohrt, CK AF Barker, TL Gettayacamin, M Hansukjariya, P Van Gessel, Y Melendez, V Teja-Isavadharm, P Vennerstrom, J Miller, RS Ohrt, CK TI Efficacy of methylene blue and artesunate as combination antimalarial therapy in a rhesus monkey model of uncomplicated blood-stage malaria. SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Meeting Abstract CT 106th Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics CY MAR 02-06, 2005 CL Orlando, FL SP Amer Soc Clin Pharmacol & Therapeut C1 Univ Nebraska, Med Ctr, Walter Reed Army Inst Res, Armed Forces Res Inst Med Sci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD FEB PY 2005 VL 77 IS 2 SU S BP P59 EP P59 DI 10.1016/j.clpt.2004.12.117 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 895GI UT WOS:000226848500222 ER PT J AU Waters, NC AF Waters, NC TI Editorial from guest editor SO COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING LA English DT Editorial Material C1 Walter Reed Army Inst Res, Div Expt Therapeut, Dept Parasitol, Silver Spring, MD 20910 USA. RP Waters, NC (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Dept Parasitol, Silver Spring, MD 20910 USA. EM norman.waters@na.amedd.army.mil NR 0 TC 1 Z9 1 U1 0 U2 0 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1386-2073 J9 COMB CHEM HIGH T SCR JI Comb. Chem. High Throughput Screen PD FEB PY 2005 VL 8 IS 1 BP 3 EP 4 DI 10.2174/1386207053328110 PG 2 WC Biochemical Research Methods; Chemistry, Applied; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA 889IJ UT WOS:000226436400001 ER PT J AU Lu, JZQ Lee, PJ Waters, NC Prigge, ST AF Lu, JZQ Lee, PJ Waters, NC Prigge, ST TI Fatty acid synthesis as a target for antimalarial drug discovery SO COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING LA English DT Article DE malaria; Plasmodium falciparum; apicoplast; fatty acid synthase; type IIFAS; drug discovery; acyl carrier protein; malonyl-coenzyme A; ACP transacylase; beta-ketoacyl-ACP synthase; beta-ketoacyl-ACP reductase; beta-hydroxyacyl-ACP dehydratase; and enoyl-ACP reductase ID ACYL CARRIER PROTEIN; ACETYL-COA CARBOXYLASE; ENOYL-ACP REDUCTASE; PARASITE PLASMODIUM-FALCIPARUM; HYDROXYDECANOYL THIOESTER DEHYDRASE; ESCHERICHIA-COLI; TOXOPLASMA-GONDII; CRYSTAL-STRUCTURE; SYNTHASE-III; ACTIVE-SITE AB In biological systems. fatty acids can be synthesized by two related, but distinct de novo fatty acid synthase (FAS) pathways. Human cells rely on a type I FAS whereas plants, bacteria and other microorganisms contain type II FAS pathways. This difference exposes the type II FAS enzymes as potential targets for antimicrobial drugs that have little to no side effects in the human host. A number of inhibitors of type II FAS enzymes have been discovered - many of which have anti-bacterial activity. Extensive biochemical and structural studies have shed light on how these compounds inhibit their target enzymes, laying the foundation for the design of inhibitors with increased potency. Recent work has shown that malaria parasites do not contain a type I FAS and rely solely oil a type II FAS for the de novo biosynthesis of fatty acids. The malaria FAS enzymes are therefore an exciting Source of new drug targets, and are being actively exploited by several drug discovery efforts. Rapid progress has been made, largely due to the vast body of mechanistic and structural information about type II FAS enzymes from bacteria and the availability of inhibitors. Ongoing antimalarial drug discovery projects wilt be described in this review as well as background information about the well-studied bacterial type II FAS enzymes. C1 Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Prigge, ST (reprint author), Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. EM sprigge@jhsph.edu NR 95 TC 39 Z9 41 U1 2 U2 11 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1386-2073 EI 1875-5402 J9 COMB CHEM HIGH T SCR JI Comb. Chem. High Throughput Screen PD FEB PY 2005 VL 8 IS 1 BP 15 EP 26 DI 10.2174/1386207053328192 PG 12 WC Biochemical Research Methods; Chemistry, Applied; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA 889IJ UT WOS:000226436400003 PM 15720194 ER PT J AU Keenan, SM Geyer, JA Welsh, WJ Prigge, ST Waters, NC AF Keenan, SM Geyer, JA Welsh, WJ Prigge, ST Waters, NC TI Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors SO COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING LA English DT Article DE CDK; Pfmrk; malaria; Plasmodium folciparum; rational drug design; in silico; virtual screening; inhibitors ID ANTIMALARIAL-DRUG-RESISTANCE; HIV-1 PROTEASE INHIBITORS; CHEMICAL INHIBITORS; BINDING AFFINITIES; GENETIC ALGORITHM; FLEXIBLE DOCKING; INK4 INHIBITORS; CDK4 INHIBITORS; LIBRARY DESIGN; CELL-CYCLE AB New chemical classes of compounds Must be introduced into the malaria drug development pipeline in an effort to develop new chemotherapy options for the fight against malaria. In this review we describe an iterative approach designed to identify potent inhibitors of a kinase family that collectively functions as key regulators of the cell cycle. Cyclin-dependent protein kinases (CDKs) are attractive drug targets in numerous diseases and, most recently, they have become the focus of rational drug design programs for the development of new antimalarial agents. Our approach uses experimental and virtual screening methodologies to identify and refine chemical inhibitors and increase the success rate of discovering potent and selective inhibitors. The active pockets of the plasmodial CDKs are unique in terms of size, shape and amino acid composition compared with those of the mammalian orthologues. These differences exemplified through the use of screening assays, molecular modeling, and crystallography can be exploited for inhibitor design. To date, several classes of compounds including quinolines and oxindoles have been identified as selective inhibitors of the plasmodial CDK7 homologue, Pfmrk. From these initial studies and through the iterative rational drug design process, more potent, selective, and most importantly, chemically unique compound classes have been identified as effective inhibitors of the plasmodial CDKs and the malarial parasite. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA. Univ Med & Dent New Jersey, Inst Informat, Piscataway, NJ 08854 USA. Johns Hopkins Univ, Dept Mol Microbiol & Immunol, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. RP Waters, NC (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM norman.waters@na.amedd.army.mil NR 79 TC 34 Z9 36 U1 0 U2 3 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1386-2073 J9 COMB CHEM HIGH T SCR JI Comb. Chem. High Throughput Screen PD FEB PY 2005 VL 8 IS 1 BP 27 EP 38 DI 10.2174/1386207053328183 PG 12 WC Biochemical Research Methods; Chemistry, Applied; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA 889IJ UT WOS:000226436400004 PM 15720195 ER PT J AU Shearer, TW Smith, KS Diaz, D Asher, C Ramirez, J AF Shearer, TW Smith, KS Diaz, D Asher, C Ramirez, J TI The role of in vitro ADME assays in antimalarial drug discovery and development SO COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING LA English DT Article DE ADME; antimalarial drugs; metabolism; mass spectrometry; drug-drug interactions; permeability; modeling ID MEMBRANE PERMEATION ASSAY; TANDEM MASS-SPECTROMETRY; ELIMINATION HALF-LIFE; HIGH-THROUGHPUT; METABOLIC STABILITY; INTESTINAL-MUCOSA; CACO-2 CELLS; HUMAN LIVER; PERMEABILITY CHARACTERISTICS; CYP2C9-MEDIATED METABOLISM AB The high level of attrition of drugs in clinical development has led pharmaceutical companies to increase the efficiency of their lead identification and development through techniques such as combinatorial chemistry and high-throughput (HTP) screening. Since the major reasons for clinical drug candidate failure other than efficacy are pharmacokinetics and toxicity, attention has been focused on assessing properties Such as metabolic stability, drug-drug interactions (DDI), and absorption earlier in the drug discovery process. Animal studies are simply too labor-intensive and expensive to use for evaluating every hit, so it has been necessary to develop and implement higher throughput in vitro ADME screens to manage the large number of compounds of interest. The antimalarial drug development program at the Walter Reed Army Institute of Research, Division of Experimental Therapeutics (WRAIR/ET) has adopted this paradigm in its search for a long-term prophylactic for the prevention of malaria. The overarching goal of this program is to develop new, long half-life, orally bioavailable compounds with potent intrinsic activity against liver- and blood-stage parasites. From the WRAIR HTP antimalarial screen, numerous compounds are regularly identified with potent activity. These hits are now immediately evaluated using a panel of in vitro ADME screens to identify and predict compounds that will meet our specific treatment criteria. In this review, the WRAIR ADME screening program for antimalarial drugs is described as well as how we have implemented it to predict the ADME properties of small molecule for the identification of promising drug candidates. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Shearer, TW (reprint author), Alcon Labs Inc, 6201 S Freeway,M-S R9-13, Ft Worth, TX 76134 USA. EM todd.shearer@na.amedd.army.mil NR 75 TC 8 Z9 9 U1 0 U2 7 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1386-2073 J9 COMB CHEM HIGH T SCR JI Comb. Chem. High Throughput Screen PD FEB PY 2005 VL 8 IS 1 BP 89 EP 98 DI 10.2174/1386207053328129 PG 10 WC Biochemical Research Methods; Chemistry, Applied; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA 889IJ UT WOS:000226436400009 PM 15720200 ER PT J AU Caponero, J Tenorio, JAS Levendis, YA Carlson, JB AF Caponero, J Tenorio, JAS Levendis, YA Carlson, JB TI Emissions of batch combustion of waste tire chips: The pyrolysis effect SO COMBUSTION SCIENCE AND TECHNOLOGY LA English DT Article DE waste tires; tire chips; pyrolysis; combustion; emissions; PAH; soot ID POLYCYCLIC AROMATIC-HYDROCARBON; PULVERIZED COAL; PLASTICS; PAH; PARTICULATE; POLYSTYRENE; EVOLUTION; PRODUCTS; CRUMB; FUEL AB Staged pyrolysis and combustion of waste tire chips was investigated as a technique to minimize emissions of pollutants.. Fixed quantities of chips were introduced to a furnace under pyrolytic conditions (in nitrogen) and devolatilized at furnace temperatures in the range 500-1000degreesC. The pyrolyzate gases were then mixed with additional streams of either nitrogen or oxygen in a venturi mixer, placed in-side the furnace. In the oxygen case, a nominally premixed flame occurred at the exit of the venturi, still inside the furnace. The effluent of either case was channeled to a secondary furnace for further treatment at 1000degreesC for a duration of 0.6s. Sampling for combustion emissions, including products of incomplete combustion (PIC), took place at the exits of both furnaces. Sampled species included CO2, CO, polynuclear aromatic hydrocarbons (PAHs), particulates, as well as nitrogen and sulfur oxides. Results showed that under inert conditions in both furnaces (pyrolysis-pyrolysis case) the emissions of PAHs and particulates from the primary furnace were high and drastically increased by the secondary furnace treatment. To the contrary, in the pyrolysis-oxidation case, when the pyrolyzates ignited and formed a flame at the exit of the venturi, the particulate and PAH emissions were low at the exit of the primary furnace. PIC were further reduced in the secondary furnace as oxidative conditions prevailed therein. As these experiments measured the PAH and soot amounts in the tire pyrolyzates before and after the flame, they illustrated the effectiveness of a nominally premixed flame for oxidizing such species. They also illustrated that a sequential pyrolysis-oxidation approach has the potential for low emissions in waste tire-to-energy plants. C1 Northeastern Univ, Coll Engn, Boston, MA 02115 USA. SENAI, Natl Ind Training Serv, Salvador, BA, Brazil. Univ Sao Paulo, Polytech Sch, Sao Paulo, Brazil. USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Levendis, YA (reprint author), Northeastern Univ, Coll Engn, Boston, MA 02115 USA. EM y.levendis@neu.edu RI Caponero, Jefferson/D-2966-2009 NR 24 TC 10 Z9 10 U1 1 U2 8 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0010-2202 J9 COMBUST SCI TECHNOL JI Combust. Sci. Technol. PD FEB PY 2005 VL 177 IS 2 BP 347 EP 381 DI 10.1080/00102200590900516 PG 35 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical SC Thermodynamics; Energy & Fuels; Engineering GA 895BJ UT WOS:000226835600006 ER PT J AU Wang, Y Fang, SC AF Wang, Y Fang, SC TI A geometric programming approach for bivariate cubic L-1 splines SO COMPUTERS & MATHEMATICS WITH APPLICATIONS LA English DT Article DE Cubic L-1 spline; geometric programming; interpolation; spline function; bivariate ID MULTISCALE INTERPOLATION AB Bivariate cubic L-1 splines provide C-1-smooth, shape-preserving interpolation of arbitrary data, including data with abrupt changes in spacing and magnitude. The minimization principle for bivariate cubic L-1 splines results in a nondifferentiable convex optimization problem. This problem is reformulated as a generalized geometric programming problem. A geometric dual with a linear objective function and convex cubic constraints is derived. A linear system for dual-to-primal conversion is established. The results of computational experiments are presented. (c) 2005 Elsevier Ltd. All rights reserved. C1 N Carolina State Univ, Raleigh, NC 27695 USA. USA, Res Off, Army Res Lab, Res Triangle Pk, NC 27709 USA. SAS Inst Inc, Cary, NC 27513 USA. Tsing Hua Univ, Dept Math Sci, Beijing 100084, Peoples R China. Tsing Hua Univ, Dept Ind Engn, Beijing 100084, Peoples R China. RP Wang, Y (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA. EM ywang16@eos.ncsu.edu; fang@eos.ncsu.edu NR 17 TC 6 Z9 6 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0898-1221 J9 COMPUT MATH APPL JI Comput. Math. Appl. PD FEB PY 2005 VL 49 IS 4 BP 481 EP 514 DI 10.1016/j.camwa.2004.11.003 PG 34 WC Mathematics, Applied SC Mathematics GA 907CV UT WOS:000227693800001 ER PT J AU Dhainaut, JF Shorr, AF Macias, WL Kollef, MJ Levi, M Reinhart, K Nelson, DR AF Dhainaut, JF Shorr, AF Macias, WL Kollef, MJ Levi, M Reinhart, K Nelson, DR TI Dynamic evolution of coagulopathy in the first day of severe sepsis: Relationship with mortality and organ failure SO CRITICAL CARE MEDICINE LA English DT Article DE sepsis; coagulation; prothrombin time; antithrombin; D-dimer; mortality; Sequential Organ Failure Assessment ID DISSEMINATED INTRAVASCULAR COAGULATION; CRITICALLY-ILL PATIENTS; SEPTIC SHOCK; PROTEIN-C; NEUTROPENIC PATIENTS; ANTITHROMBIN-III; CYTOKINE LEVELS; UNITED-STATES; SOFA SCORE; D-DIMER AB Objective: To determine whether changes in coagulation biomarkers during the first day of severe sepsis correlate with progression from single to multiple organ failure and subsequent death. Design: Analysis of secondary endpoints in a prospective, randomized, placebo-controlled, multinational clinical trial (PROWESS). Setting: The study involved 164 medical centers. Patients. A total of 840 patients who met criteria for severe sepsis and were randomized to receive placebo plus supportive care. Interventions. None. Measurements and Main Results. Coagulation biomarkers, prothrombin time, antithrombin activity, and D-dimer and protein C levels were measured, and Sequential Organ Failure Assessment was performed daily. Multiple logistic regression analysis identified baseline antithrombin activity < 54% and changes in prothrombin time, D-dimer, and antithrombin activity during the first calendar day after the onset of the first sepsis-induced organ dysfunction (i.e., the first day of severe sepsis, day 1) as predictive of 28-day mortality (p less than or equal to .01). A composite coagulopathy score was determined using points for predetermined levels of change from baseline to day 1. The composite coagulopathy score correlated with progression from single to multiple organ failure (p = .0007), time to resolution of organ failure (p = .0004), and 28-day mortality (p < .0001). Combining the composite coagulopathy score with the Acute Physiology and Chronic Health Evaluation (APACHE) II score improved ability to identify patients who would progress to multiple organ failure (area under receiver operating characteristic curve 0.61 APACHE II vs. 0.65 APACHE II + composite coagulopathy score) and who would die (area under receiver operating characteristic curve 0.69 APACHE II vs. 0.74 APACHE II + composite coagulopathy score). Conclusions. Continuation or worsening of coagulopathy during the first day of severe sepsis was associated with increased development of new organ failure and 28-day mortality. These results further suggest that coagulation abnormalities contribute to organ failure and death. C1 Univ Paris 05, Cochin Hosp, Cochin Inst, APHP,Cochin Port Royal Med Sch,Dept Intens Care, F-75679 Paris 14, France. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA. Barnes Jewish Hosp, Dept Crit Care Med, St Louis, MO 63110 USA. Univ Amsterdam, Acad Med Ctr, Dept Med, NL-1105 AZ Amsterdam, Netherlands. Clin Anaesthesiol & Intens Care, Jena, Germany. RP Dhainaut, JF (reprint author), Univ Paris 05, Cochin Hosp, Cochin Inst, APHP,Cochin Port Royal Med Sch,Dept Intens Care, Pavillon Cornil,27 Rue Faubourg St Jacques, F-75679 Paris 14, France. EM francois.dhainaut@cch.ap-hop-paris.fr NR 32 TC 125 Z9 143 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD FEB PY 2005 VL 33 IS 2 BP 341 EP 348 DI 10.1097/01.CCM.0000153520.31562.48 PG 8 WC Critical Care Medicine SC General & Internal Medicine GA 898LE UT WOS:000227077500008 PM 15699837 ER PT J AU Burroughs, R Elston, DM AF Burroughs, R Elston, DM TI What's eating you? Fire ants SO CUTIS LA English DT Editorial Material ID VENOM C1 Geisinger Med Ctr, Dept Dermatol, Danville, PA 17821 USA. Geisinger Med Ctr, Dept Lab Med, Danville, PA 17821 USA. Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. RP Elston, DM (reprint author), Geisinger Med Ctr, Dept Dermatol, 100 N Acad Ave, Danville, PA 17821 USA. EM delston@geisinger.edu NR 17 TC 1 Z9 1 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI CHATHAM PA 26 MAIN ST, STE A, CHATHAM, NJ 07928-2402 USA SN 0011-4162 J9 CUTIS JI Cutis PD FEB PY 2005 VL 75 IS 2 BP 85 EP 89 PG 5 WC Dermatology SC Dermatology GA 898CU UT WOS:000227054400002 PM 15773528 ER PT J AU Duncan, MB Horwhat, JD Maydonovitch, CL Ramos, F Colina, R Gaertner, E Yang, H Wong, RKH AF Duncan, MB Horwhat, JD Maydonovitch, CL Ramos, F Colina, R Gaertner, E Yang, H Wong, RKH TI Use of methylene blue for detection of specialized intestinal metaplasia in GERD patients presenting for screening upper endoscopy SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE methylene blue; reflux disease; specialized intestinal metaplasia ID BARRETTS-ESOPHAGUS; ESOPHAGOGASTRIC JUNCTION; DYSPLASIA; CANCER; SURVEILLANCE; TRIAL AB The ability of randomly obtained biopsy specimens to identify intestinal metaplasia in the distal esophagus is low. Use of vital staining has been suggested, as stains are taken up by areas histologically identified as specialized intestinal metaplasia (SIM). This study evaluated the role of methylene blue (MB) staining for identification of SIM in GERD patients undergoing a screening endoscopy. Chromoendoscopy of the distal esophagus using 1% MB was performed on 52 GERD patients presenting for their first endoscopy. Biopsies were obtained from areas that were stained darkly, stained lightly, unstained, or macroscopically abnormal. In patients with no MB staining, four-quadrant biopsy of the distal esophagus was performed. Twenty-seven patients (52%) showed staining with MB, while 25 patients did not. Two hundred sixty-six biopsies were obtained. SIM was detected in 11 (21%) subjects (SIM+) but not in the remaining 41 (SIM-). One hundred sixty-five biopsies were unstained (25 SIM+, 140 SIM-) and 101 were stained (12 SIM+, 89 SIM-). The per-biopsy sensitivity and specificity of MB for detection of SIM were 32.4 and 85%, while the per-patient sensitivity and specificity were 63.3 and 51.2%. MB staining for detection of SIM in GERD patients without a macroscopic appearance suggestive of a columnar-lined esophagus is a poor screening tool for SIM. C1 Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC USA. RP Duncan, MB (reprint author), 5809 Johnson Ct, Bethesda, MD 20817 USA. EM M2duncan@hotmail.com NR 16 TC 7 Z9 8 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD FEB PY 2005 VL 50 IS 2 BP 389 EP 393 DI 10.1007/s10620-005-1616-y PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 896YG UT WOS:000226969900032 PM 15745106 ER PT J AU Liu, H Yang, ZH Gaulke, MS AF Liu, H Yang, ZH Gaulke, MS TI Structural identification and finite element modeling of a 14-story office building using recorded data SO ENGINEERING STRUCTURES LA English DT Article DE recorded seismic data; structural identification; finite element modeling ID SITE RESPONSE; ALASKA; ANCHORAGE AB Presented is a detailed case study on structural identification and Finite Element (FE) modeling of a 14-story office building. Specifically, system identification tools were used to identify the structural dynamic properties based on recorded seismic data. This identified model was compared with a model based on IBC 2000 using the fundamental period, design response spectral acceleration, and base shear. The two models were found to be about 20% different in these parameters. Then, a series of three-dimensional FE models were created to study various approaches for improving the accuracy of FE models quantitatively. Sensitivity study shows that the most effective ways to improve the accuracy of linear FE models are to refine the mass calculation and consider the panel zone rigidity of the beam/column connections for this type of structure. Simulated seismic responses were compared with the observed responses and it is found that a FE model can be calibrated to give a good prediction of earthquake response. (C) 2004 Elsevier Ltd. All rights reserved. C1 Univ Alaska, Sch Engn, Anchorage, AK 99508 USA. USA, Corps Engineers, Elmendorf AFB, AK 99506 USA. RP Yang, ZH (reprint author), Univ Alaska, Sch Engn, 3211 Providence Ave, Anchorage, AK 99508 USA. EM afhl@uaa.alaska.edu; afzy@uaa.alaska.edu; michael.s.gaulke@usace.army.mil NR 25 TC 10 Z9 10 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-0296 J9 ENG STRUCT JI Eng. Struct. PD FEB PY 2005 VL 27 IS 3 BP 463 EP 473 DI 10.1016/j.engstruct.2004.11.012 PG 11 WC Engineering, Civil SC Engineering GA 904AT UT WOS:000227468100015 ER PT J AU Weiss, CA Malone, PG Hock, VF Mcinerney, MK Morefield, SW AF Weiss, CA Malone, PG Hock, VF Mcinerney, MK Morefield, SW TI Use of small-scale electro-osmotic systems in controlling groundwater movement around structures SO ENVIRONMENTAL & ENGINEERING GEOSCIENCE LA English DT Article DE electro-osmosis; electrokinetics; dewatering; moisture control; foundations; structures ID SOILS AB Small-scale electro-osmotic systems for use around commercial and residential structures are becoming increasingly common as a method of controlling the water seeping through concrete foundations or seeping into basements. and other underground structures. These systems are designed for continuous use in moving water out of the soil adjacent to the structures. There is little engineering guidance on the selection and installation of the components for these small-scale systems. Features such as soil conditions, positioning of electrodes, operating voltages, operating patterns for decreasing polarization problems, and selecting the types of electrodes are critical in assuring efficient operation and a long service life. By screening sites to make sure that the geological conditions are appropriate and tailoring the system to fit the site, electro-osmotic dewatering can be applied safely and effectively, giving a property owner a method other than conventional drains for controlling groundwater problems on a building site. C1 USACE, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Weiss, CA (reprint author), USACE, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 18 TC 1 Z9 1 U1 2 U2 4 PU GEOLOGICAL SOC AMERICA, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1078-7275 J9 ENVIRON ENG GEOSCI JI Environ. Eng. Geosci. PD FEB PY 2005 VL 11 IS 1 BP 53 EP 60 DI 10.2113/11.1.53 PG 8 WC Engineering, Environmental; Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 952MX UT WOS:000231009200007 ER PT J AU Martt, DF Shakoor, A Greene, BH AF Martt, DF Shakoor, A Greene, BH TI Austin Dam, Pennsylvania: The sliding failure of a concrete gravity dam SO ENVIRONMENTAL & ENGINEERING GEOSCIENCE LA English DT Article DE concrete dam; foundation failure; sliding failure; uplift pressure; cyclopean concrete AB The Austin Dam, a concrete gravity structure, failed catastrophically on September 30, 1911, less than 2 years after its construction. Several engineering evaluations of the failure have been made since immediately following the disaster. Engineers involved in the construction of the dam recognized early on that the dam failed by sliding on its rock foundation. The dam was constructed on interbedded sedimentary rock, and its foundation was taken to a depth of approximately 4 ft (1.2 m). Although studies of the orientation of the failed blocks of the dam and other site evidence pointed to a sliding failure, no detailed quantitative studies have been done. Recent test pit excavations showed that the critical interface for sliding was a sandstone/shale contact located at a shallow depth below the base of the dam. Stability analyses based on shear-strength tests of the different interfaces of the foundation (concrete/sandstone, sandstone/sandstone, sandstone/ shale, and shale/shale) showed that the dam was safe against a bearing capacity failure, but unsafe with respect to sliding and overturning. The lowest factor of safety of 0.6 corresponded to the sandstone/shale interface, as stated above. The major factors believed to have contributed to the failure include low shear strength of the foundation materials, inadequate provisions for reducing the uplift pressure, and weak concrete. The project stands as the sixth worst dam failure in U.S. history in terms of loss of life, and this case history provides numerous lessons with regard to dam safety. C1 AGES Inc, Canonsburg, PA 15317 USA. Kent State Univ, Dept Geol, Kent, OH 44242 USA. USA, Corps Engineers, Geotech Branch, Pittsburgh, PA 15222 USA. RP Martt, DF (reprint author), AGES Inc, Southpointe Business Pk 4,Grandiew Circle, Canonsburg, PA 15317 USA. NR 29 TC 5 Z9 5 U1 0 U2 17 PU GEOLOGICAL SOC AMERICA, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1078-7275 J9 ENVIRON ENG GEOSCI JI Environ. Eng. Geosci. PD FEB PY 2005 VL 11 IS 1 BP 61 EP 72 DI 10.2113/11.1.61 PG 12 WC Engineering, Environmental; Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 952MX UT WOS:000231009200008 ER PT J AU Koff, JM Napierkowski, JJ Smith, MT AF Koff, JM Napierkowski, JJ Smith, MT TI Retained endoclip SO GASTROINTESTINAL ENDOSCOPY LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. RP Koff, JM (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD FEB PY 2005 VL 61 IS 2 BP 287 EP 287 AR PII S0016-5107(04)02575-6 DI 10.1016/S0016-5107(04)02572-6 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 900SH UT WOS:000227234100018 PM 15729242 ER PT J AU Harmon, RS De Lucia, FC Miziolek, AW McNesby, KL Walters, RA French, PD AF Harmon, RS De Lucia, FC Miziolek, AW McNesby, KL Walters, RA French, PD TI Laser-induced breakdown spectroscopy (LIBS) - an emerging field-portable sensor technology for real-time, in-situ geochemical and environmental analysis SO GEOCHEMISTRY-EXPLORATION ENVIRONMENT ANALYSIS LA English DT Article DE laser-induced breakdown spectroscopy; field-portable elemental analysis; Pb in soil ID INDUCED PLASMA SPECTROSCOPY; HEAVY-METAL AEROSOLS; ELEMENTAL ANALYSIS; SOILS; SPECTROMETRY; SYSTEM; IONS; LEAD; TOOL AB Laser-induced breakdown spectroscopy (LIBS) is a simple spark spectrochemical sensor technology in which a laser beam is directed at a sample to create a high-temperature microplasma. A spectrometer/array detector is used to disperse the light emission and detect its intensity at specific wavelengths. LIBS has many attributes that make it an attractive tool for chemical analysis. A recent breakthrough in component development, the commercial launching of a small, high-resolution spectrometer, has greatly expanded the utility of LIBS and resulted in a new potential for field-portable broadband LIBS because the technique is now sensitive simultaneously to A chemical elements due to detector response in the 200 to 980 nm range with 0.1 nm spectral resolution. Other attributes include: (a) small size and weight; (b) technologically mature, inherently rugged, and affordable components; (c) in-situ analysis with no sample preparation required; (d) inherent high sensitivity; (e) real-time response; and (0 point sensing or standoff detection. LIBS sensor systems can be used to detect and analyse target samples by identifying A constituent elements and by determining either their relative or absolute abundances. C1 USA, Res Off, Res Triangle Pk, NC 27709 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Ocean Opt Inc, Winter Pk, FL 32792 USA. ADA Technol Inc, Littleton, CO 80127 USA. RP Harmon, RS (reprint author), USA, Res Off, POB 12211, Res Triangle Pk, NC 27709 USA. EM russell.harmon@usarmy.mil RI De Lucia, Frank/D-5630-2012 NR 41 TC 93 Z9 98 U1 4 U2 27 PU GEOLOGICAL SOC PUBL HOUSE PI BATH PA UNIT 7, BRASSMILL ENTERPRISE CENTRE, BRASSMILL LANE, BATH BA1 3JN, AVON, ENGLAND SN 1467-7873 J9 GEOCHEM-EXPLOR ENV A JI Geochem.-Explor. Environ. Anal. PD FEB PY 2005 VL 5 BP 21 EP 28 DI 10.1144/1467-7873/03-059 PN 1 PG 8 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 906XA UT WOS:000227676900003 ER PT J AU Ketcham, SA Moran, ML Lacombe, J Greenfield, RJ Anderson, TS AF Ketcham, SA Moran, ML Lacombe, J Greenfield, RJ Anderson, TS TI Seismic source model for moving vehicles SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE finite-difference time-domain (FDTD) methods; modeling; seismic inverse problems; seismic signal processing; seismic waves; vehicles ID EIGENSYSTEM REALIZATION-ALGORITHM; WAVE PROPAGATION; ELASTIC MEDIA AB We develop a method for the loading of ground by moving vehicles in large finite-difference time-domain simulations of seismic wave propagation. The objective is to realistically produce two distinct types of ground loading for either wheeled or tracked vehicles in our propagation models: lower frequency loading associated with suspension dynamics and higher frequency impulsive loading associated with tire treads or wheels rolling over individual track blocks. These loading characteristics are important because field measurements show that vehicle ground forcing in both frequency bands produces seismic surface waves that networked sensors can remotely process for security applications. The method utilizes a vehicle-dynamics model to calculate a response to vehicle acceleration and ground features such as bumps; calculates forces transmitted to the ground; distributes these forces to staggered points of a finite-difference model; and simulates seismic wave propagation away from the vehicle. We demonstrate the method using bounce-and-pitch models of wheeled and tracked vehicles. We show that by carefully preprocessing force inputs, we can accurately simulate wave propagation and seismic signatures in finite-difference analyses of vehicles moving continuously over terrain. C1 US Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Greenfield & Associates, State Coll, PA 16803 USA. RP Ketcham, SA (reprint author), US Army Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. EM Stephen.A.Ketcham@erdc.usace.army.mil NR 18 TC 12 Z9 14 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD FEB PY 2005 VL 43 IS 2 BP 248 EP 256 DI 10.1109/TGRS.2004.842212 PG 9 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 890HK UT WOS:000226502100005 ER PT J AU Kwon, H Nasrabadi, NM AF Kwon, H Nasrabadi, NM TI Kernel RX-algorithm: A nonlinear anomaly detector for hyperspectral imagery SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE anomaly detection; hyperspectral images; kernel-based learning; kernels; target detection ID SUBSPACE PROJECTION APPROACH; CLASSIFICATION; SEGMENTATION; PERFORMANCE; PATTERN; MODELS; SPACE AB In this paper, we present a nonlinear version of the well-known anomaly detection method referred to as the RX-algorithm. Extending this algorithm to a feature space associated with the original input space via a certain nonlinear mapping function can provide a nonlinear version of the RX-algorithm. This nonlinear RX-algorithm, referred to as the kernel RX-algorithm, is basically intractable mainly due to the high dimensionality of the feature space produced by the nonlinear mapping function. However, in this paper it is shown that the kernel RX-algorithm can easily be implemented by kernelizing the RX-algorithm in the feature space in terms of kernels that implicitly compute dot products in the feature space. Improved performance of the kernel RX-algorithm over the conventional RX-algorithm is shown by testing several hyperspectral imagery for military target and mine detection. C1 US Army Res Lab, Adelphi, MD 20783 USA. RP Kwon, H (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM hkwon@arl.army.mil; nnasraba@arl.army.mil NR 29 TC 181 Z9 220 U1 5 U2 24 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD FEB PY 2005 VL 43 IS 2 BP 388 EP 397 DI 10.1109/TGRS.2004.841487 PG 10 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 890HK UT WOS:000226502100020 ER PT J AU Bambha, NK Bhattacharyya, SS AF Bambha, NK Bhattacharyya, SS TI Joint application mapping interconnect synthesis techniques for embedded chip-scale multiprocessors SO IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS LA English DT Article DE embedded multiprocessors; interconnect synthesis; scheduling; task graphs ID SYSTEMS; GRAPHS; ALGORITHM AB As transistor sizes shrink, interconnects represent an increasing bottleneck for chip designers. Several groups are developing new interconnection methods and system architectures to cope with this trend. New architectures require new methods for high-level application mapping and hardware/software codesign. In this paper, we present high-level scheduling and interconnect topology synthesis techniques for embedded multiprocessor systems-on-chip that are streamlined for one or more digital signal processing applications. That is, we seek to synthesize an application-specific interconnect topology. We show that flexible interconnect topologies utilizing low-hop communication between processors offer advantages for reduced power and latency. We show that existing multiprocessor scheduling algorithms can deadlock if the topology graph is not strongly connected, or if a constraint is imposed on the maximum number of hops allowed for communication. We detail an efficient algorithm that can be used in conjunction with existing scheduling algorithms for avoiding this deadlock. We show that it is advantageous to perform application scheduling and interconnect synthesis jointly, and present a probabilistic scheduling/ interconnect algorithm that utilizes graph isomorphism to pare the design space. C1 USA, Res Lab, Adelphi, MD 20783 USA. Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. Univ Maryland, Inst Adv Comp Studies, College Pk, MD 20742 USA. RP USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nbambha@eng.umd.edu; ssb@eng.umd.edu OI Bhattacharyya, Shuvra/0000-0001-7719-1106 NR 30 TC 12 Z9 15 U1 0 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1045-9219 EI 1558-2183 J9 IEEE T PARALL DISTR JI IEEE Trans. Parallel Distrib. Syst. PD FEB PY 2005 VL 16 IS 2 BP 99 EP 112 DI 10.1109/TPDS.2005.20 PG 14 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 881HI UT WOS:000225853600002 ER PT J AU Davis, J Nehab, D Ramamoorthi, R Rusinkiewicz, S AF Davis, J Nehab, D Ramamoorthi, R Rusinkiewicz, S TI Spacetime stereo: A unifying framework for depth from triangulation SO IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE LA English DT Article DE depth from triangulation; stereo; spacetime stereo ID VISION; ACQUISITION AB Depth from triangulation has traditionally been investigated in a number of independent threads of research, with methods such as stereo, laser scanning, and coded structured light considered separately. In this paper, we propose a common framework called spacetime stereo that unifies and generalizes many of these previous methods. To show the practical utility of the framework, we develop two new algorithms for depth estimation: depth from unstructured illumination change and depth estimation in dynamic scenes. Based on our analysis, we show that methods derived from the spacetime stereo framework can be used to recover depth in situations in which existing methods perform poorly. C1 USA, Honda Res Inst, Mountain View, CA 94041 USA. Princeton Univ, Dept Comp Sci, Princeton, NJ 08544 USA. Columbia Univ, Dept Comp Sci, New York, NY 10027 USA. RP USA, Honda Res Inst, 800 Calif St,Suite 300, Mountain View, CA 94041 USA. EM jedavis@ieee.org; diego@cs.princeton.edu; ravir@cs.columbia.edu; smr@cs.princeton.edu NR 33 TC 95 Z9 99 U1 1 U2 14 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0162-8828 EI 1939-3539 J9 IEEE T PATTERN ANAL JI IEEE Trans. Pattern Anal. Mach. Intell. PD FEB PY 2005 VL 27 IS 2 BP 296 EP 302 DI 10.1109/TPAMI.2005.37 PG 7 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 879AR UT WOS:000225689300014 PM 15688568 ER PT J AU Sidiropoulos, ND Swami, A Sadler, BM AF Sidiropoulos, ND Swami, A Sadler, BM TI Quasi-ML period estimation from incomplete timing data SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article ID MISSING OBSERVATIONS; SPECTRAL-ANALYSIS AB Given a noisy sequence of (possibly shifted) integer multiples of a certain period, it is often of interest to accurately estimate the period. With known integer regressors, the problem is classical linear regression. In many applications, however, the regressors are unknown integers, and only loose bounds on the period are available. Examples include hop period and timing estimation, wherein hops may be missed at the output of the frequency discriminator or the emitter may hop out of band; Pulse Repetition Interval (PRI) analysis; and passive rotating-beam radio scanning. We study several pertinent period estimators. Our emphasis is on a Quasi-Maximum Likelihood approach developed herein and an earlier method based on the Fourier Transform of a Dirac delta train representation of the data. Surprisingly, both are capable of attaining the clairvoyant Cramer-Rao Bound at moderate signal-to-noise ratios (SNRs), even for short (e.g., 10) samples. We carefully address parameter identifiability issues and corroborate our findings with extensive simulations. C1 Tech Univ Crete, Dept Elect & Comp Engn, Khania 73100, Crete, Greece. Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Sidiropoulos, ND (reprint author), Tech Univ Crete, Dept Elect & Comp Engn, Khania 73100, Crete, Greece. EM nikos@telecom.tuc.gr; aswami@arl.army.mil; bsadler@arl.army.mil NR 13 TC 14 Z9 15 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD FEB PY 2005 VL 53 IS 2 BP 733 EP 739 DI 10.1109/TSP.2004.840761 PN 1 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 887YI UT WOS:000226341000033 ER PT J AU Xie, H Gursel, I Ivins, BE Singh, M O'Hagan, DT Ulmer, JB Klinman, DM AF Xie, H Gursel, I Ivins, BE Singh, M O'Hagan, DT Ulmer, JB Klinman, DM TI CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine SO INFECTION AND IMMUNITY LA English DT Article ID NECROSIS-FACTOR-ALPHA; HEPATITIS-B-VACCINE; CATIONIC MICROPARTICLES; BACILLUS-ANTHRACIS; BACTERIAL-DNA; INTERFERON-GAMMA; SURFACE-ANTIGEN; RHESUS MACAQUES; MOTIFS; SAFETY AB To reduce the biothreat posed by anthrax, efforts are under way to improve the protection afforded by vaccination. This work examines the ability of inummostimulatory CpG oligodeoxynucleotides (ODN) adsorbed onto cationic polylactide-co-glycolide (PLG) microparticles (CpG ODN-PLG) to accelerate and boost the protective immunity elicited by Anthrax Vaccine Adsorbed (AVA, the licensed human anthrax vaccine). The results indicate that coadministering CpG ODN-PLG with AVA induces a stronger and faster immunoglobulin G response against the protective antigen of anthrax than AVA alone. Immunized mice were protected from lethal anthrax challenge within 1 week of vaccination with CpG ODN-PLG plus AVA, with the level of protection correlating with serum immunoglobulin G anti-protective antigen titers. C1 US FDA, Ctr Biol Evaluat & Res, Sect Retroviral Immunol, Bethesda, MD 20892 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. Maryland & Chiron Vaccines, Emeryville, CA USA. RP Klinman, DM (reprint author), US FDA, Ctr Biol Evaluat & Res, Sect Retroviral Immunol, Bldg 29A,Rm 3D10, Bethesda, MD 20892 USA. EM Klinman@cber.fda.gov OI Gursel, Ihsan/0000-0003-3761-1166 NR 42 TC 76 Z9 80 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD FEB PY 2005 VL 73 IS 2 BP 828 EP 833 DI 10.1028/IAI.73.2.828-833.2005 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 893PM UT WOS:000226731700019 PM 15664922 ER PT J AU Hospenthal, DR AF Hospenthal, DR TI Voriconazole SO INFECTIONS IN MEDICINE LA English DT Editorial Material DE voriconazole; azole; antifungal therapy ID FUNGAL-INFECTIONS; AMPHOTERICIN-B; ASPERGILLOSIS; THERAPY C1 Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU SCP COMMUNICATIONS INC PI NEW YORK PA 134 W 29TH ST, NEW YORK, NY 10001-5304 USA SN 0749-6524 J9 INFECT MED JI Infect. Med. PD FEB PY 2005 VL 22 IS 2 BP 84 EP 87 PG 4 WC Infectious Diseases SC Infectious Diseases GA 893RT UT WOS:000226737600013 ER PT J AU Nguyen, JC Murphy, ME Nutman, TB Neafie, RC Maturo, S Burke, DS Turiansky, GW AF Nguyen, JC Murphy, ME Nutman, TB Neafie, RC Maturo, S Burke, DS Turiansky, GW TI Cutaneous onchocerciasis in an American traveler SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID VOLVULUS; IVERMECTIN; WORMS AB A case report of cutaneous onchocercias acquired during travels to Africa is presented. The salient epidemiologic, clinical, diagnostic, and therapeutic aspects are reviewed. Clinical and laboratory differences between onchocerciasis patients who are inhabitants of endemic areas and those who are occasional visitors to such areas are discussed. Parasitic infections, including onchocerciasis, should be considered in the differential diagnosis of pruritic eruptions in patients with a history of foreign travel to Africa, Central and South America. C1 Stanford Univ, Sch Med, Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. NIH, Helminth Immunol Sect, Bethesda, MD 20892 USA. NIH, Clin Parasitol Unit, Bethesda, MD 20892 USA. Armed Forces Inst Pathol, Parasit Dis Pathol Branch, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Turiansky, GW (reprint author), Stanford Univ, Sch Med, Walter Reed Army Med Ctr, Dermatol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM george.turiansky@na.amedd.army.mil OI /0000-0002-5704-8094 NR 18 TC 5 Z9 5 U1 0 U2 1 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD FEB PY 2005 VL 44 IS 2 BP 125 EP 128 DI 10.1111/j.1365-4632.2004.02203.x PG 4 WC Dermatology SC Dermatology GA 900RZ UT WOS:000227233300009 PM 15689210 ER PT J AU Holmquist, TJ Johnson, GR AF Holmquist, TJ Johnson, GR TI Modeling prestressed ceramic and its effect on ballistic performance SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE ceramic; prestress; damage; penetration ID HIGH-STRAIN RATE; IMPACT; PENETRATION; ALGORITHM; TARGETS AB This article presents computed results for the responses of ceramic targets, with and without prestress, subjected to projectile impact. Also presented is a computational technique to include prestress. Thin and thick ceramic target configurations are used to understand the effect prestressing has on ballistic performance. For both targets two prestress levels (small and large), and two prestress states (radial and hydrostatic) are investigated. The small prestress is similar in magnitude to values obtained experimentally and the large prestress is approximately the maximum prestress the confinement can produce (determined computationally). The targets are subjected to projectile impact and the resulting ballistic responses are evaluated. In all cases prestressing the ceramic enhanced the ballistic performance, although the effect of the different prestress conditions on the ballistic response was not always obvious. (C) 2003 Elsevier Ltd. All rights reserved. C1 Network Comp Serv Inc, Army High Performance Comp Res Ctr, Minneapolis, MN 55458 USA. RP Holmquist, TJ (reprint author), Network Comp Serv Inc, Army High Performance Comp Res Ctr, POB 581459, Minneapolis, MN 55458 USA. EM tjholm@networkcs.com NR 18 TC 40 Z9 52 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD FEB PY 2005 VL 31 IS 2 BP 113 EP 127 DI 10.1016/j.ijimpeng.2003.11.002 PG 15 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 869PP UT WOS:000224996800001 ER PT J AU O'Boyle, AL O'Boyle, JD Calhoun, B Davis, GD AF O'Boyle, AL O'Boyle, JD Calhoun, B Davis, GD TI Pelvic organ support in pregnancy and postpartum SO INTERNATIONAL UROGYNECOLOGY JOURNAL LA English DT Article DE pelvic organ prolapse quantification (POPQ); pregnancy ID GENITAL PROLAPSE; DELIVERY; POPULATION; URINARY; BIRTH; WOMEN AB The purpose of this study was to evaluate pelvic organ support during pregnancy and following delivery. This was a prospective observational study. Pelvic organ prolapse quanti. cation (POPQ) examinations were performed during each trimester of pregnancy and in the postpartum. Statistical comparisons of POPQ stage and of the nine measurements comprising the POPQ between the different time intervals were made using Wilcoxon's signed rank and the paired t-test. Comparison of POPQ stage by mode of delivery was made using Fisher's exact test. One hundred thirty-five nulliparous women underwent 281 pelvic organ support evaluations. During both the third trimester and postpartum, POPQ stage was significantly higher compared to the first trimester (p< 0.001). In the postpartum, POPQ stage was significantly higher in women delivered vaginally compared to women delivered by cesarean ( p= 0.02). In nulliparous pregnant women, POPQ stage appears to increase during pregnancy and does not change significantly following delivery. In the postpartum, POPQ stage may be higher in women delivered vaginally compared to women delivered by cesarean. C1 USN, Med Ctr, Dept Obstet & Gynecol, Portsmouth, VA 23078 USA. Rockford Mem Hosp, Rockford, IL 61103 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP O'Boyle, AL (reprint author), USN, Med Ctr, Dept Obstet & Gynecol, 620 John Paul Jones Circle, Portsmouth, VA 23078 USA. EM amyoboyle@aol.com NR 15 TC 30 Z9 33 U1 1 U2 4 PU SPRINGER LONDON LTD PI GODALMING PA SWEETAPPLE HOUSE CATTESHALL ROAD, GODALMING GU7 3DJ, SURREY, ENGLAND SN 0937-3462 J9 INT UROGYNECOL J JI Int. Urogynecol. J. PD FEB PY 2005 VL 16 IS 1 BP 69 EP 72 DI 10.1007/s00192-004-1210-4 PG 4 WC Obstetrics & Gynecology; Urology & Nephrology SC Obstetrics & Gynecology; Urology & Nephrology GA 887JY UT WOS:000226303600015 PM 15647966 ER PT J AU Kiang, JG Lu, XY Tabaku, LS Bentley, TB Atkins, JL Tsokos, GC AF Kiang, JG Lu, XY Tabaku, LS Bentley, TB Atkins, JL Tsokos, GC TI Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhage SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Kruppel-like factor 6 and 4; inducible nitric oxide synthase; whole blood ID NITRIC-OXIDE SYNTHASE; NEURONAL CELL-DEATH; HEAT-SHOCK PROTEINS; CASPASE ACTIVATION; INTRASTRIATAL HEMORRHAGE; NEUTROPHIL ACTIVATION; INFLAMMATORY RESPONSE; PULMONARY APOPTOSIS; SMALL-INTESTINE; WHOLE-BLOOD AB The aim of this study was to determine whether hemorrhage altered the caspase-3 activity and the ATP levels in rat lung and ileum tissues and determine whether resuscitation with lactated Ringer solution (LR) or whole blood (WB) reversed these changes. Male Sprague-Dawley rats were briefly anesthetized with isoflurane, and their mean arterial blood pressure was reduced from 110 to 40 mmHg by bleeding. The bled rat was then resuscitated with LR or autologous WB to bring mean arterial blood pressure back to 80 mmHg. Lung and ileum tissues were removed at the end of hemorrhage or at the end of the resuscitation period for specified bioassays. Hemorrhage increased cellular caspase-3 activity in the lung and the ileum. After the hemorrhaged rats received LR or WB, caspase-3 activity returned to the basal level in the lung and ileum, respectively. Likewise, hemorrhage decreased cellular ATP levels in lung and ileum. After LR or WB resuscitation, the cellular ATP level returned to the basal level only in the lung resuscitated with LR. The increased caspase-3 activity was associated with the increased expression of caspase-3 mRNA, which also returned to normal levels after either resuscitation. Similarly, hemorrhage increased the expression of inducible nitric oxide synthase and Kruppel-like factor 6 and decreased expression of Kruppel-like factor 4. Subsequent LR resuscitation normalized the expression of these genes in the lung tissue. Our results demonstrate that resuscitation with LR can reverse the expression of genes and their products that are thought to contribute to hemorrhage-induced lung injury. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Div Mil Casualty Res, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA. RP Kiang, JG (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Div Mil Casualty Res, 503 Robert Grant Ave,Rm 1N07, Silver Spring, MD 20910 USA. EM Juliann.Kiang@na.amedd.army.mil RI Atkins, James/B-3577-2011 NR 53 TC 13 Z9 13 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD FEB PY 2005 VL 98 IS 2 BP 550 EP 556 DI 10.1152/japplphysiol.00858.2004 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 887CZ UT WOS:000226282400018 PM 15489261 ER PT J AU Smith, MJ Jeddeloh, JA AF Smith, MJ Jeddeloh, JA TI DNA methylation in lysogens of pathogenic Burkholderia spp. requires prophage induction and is restricted to excised phage DNA SO JOURNAL OF BACTERIOLOGY LA English DT Article ID ESCHERICHIA-COLI; MCRBC; PSEUDOMALLEI; ENDONUCLEASE; RECOGNITION; MUTAGENESIS; VIRULENCE; BACTERIA; THAILAND; SYSTEM AB Burkholderia mallei-specific phage PhiE125 encodes DNA methyltransferases in both the lysogenic and replication modules within its genome. Characterization of DNA methylation in recombinant systems, specifically in PhiE125 lysogenic strains of B. mallei and Burkholderia thailandensis, revealed that, upon induction, cytosine methylation was targeted specifically to the phage episome but not the phage provirus or the host chromosome. C1 Orion Genom, St Louis, MO 63108 USA. USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Jeddeloh, JA (reprint author), Orion Genom, 4041 Forest Pk, St Louis, MO 63108 USA. EM jjeddeloh@oriongenomics.com NR 24 TC 8 Z9 8 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD FEB PY 2005 VL 187 IS 3 BP 1196 EP 1200 DI 10.1128/JB.187.3.1196-1200.2005 PG 5 WC Microbiology SC Microbiology GA 893FR UT WOS:000226705200039 PM 15659696 ER PT J AU Matzkin, E Smith, EL Freccero, D Richardson, AB AF Matzkin, E Smith, EL Freccero, D Richardson, AB TI Adequacy of education in musculoskeletal medicine SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID SCHOOL EDUCATION; STUDENTS; ANATOMY AB Background: Basic musculoskeletal knowledge is essential to the practice of medicine. A validated musculoskeletal cognitive examination was given to medical students, residents, and staff physicians in multiple disciplines of medicine to assess the adequacy of their musculoskeletal medicine training. Methods: The examination was given to 334 volunteers consisting of medical students, residents, and staff physicians. Analysis of the data collected and comparisons across disciplines were performed. Results: The average cognitive examination score was 57%. Sixty-nine participants (21%) obtained a score of greater than or equal to73.1%, the recommended mean passing score. Of the sixty-nine with a passing score, forty (58%) were orthopaedic residents and staff physicians with an overall average score of 94%. Differences in the average scores for the orthopaedic residents compared with all other specialties were significant (p <0.001). The average score was 69% for the 124 participants who stated that they had taken a required or an elective course in orthopaedics during their training compared with an average score of 50% for the 210 who had not taken an orthopaedic course (p < 0.001). When'the scores of those in orthopaedics were excluded, the average score for the participants who had taken an orthopaedic course was 59%; this difference remained significant (p < 0.001). Conclusions: Seventy-nine percent of the participants failed the basic musculoskeletal cognitive examination. This suggests that training in musculoskeletal medicine is inadequate in both medical school and nonorthopaedic residency training programs. Among the nonorthopaedists, scores were significantly better if they had taken a medical school course or residency rotation in orthopaedics, suggesting that a rotation in orthopaedics would improve the general level of musculoskeletal knowledge. C1 Univ Hawaii, Honolulu, HI 96822 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Matzkin, E (reprint author), Duke Univ, Med Ctr, Box 3615, Durham, NC 27710 USA. EM ematzki@aol.com NR 18 TC 65 Z9 65 U1 0 U2 3 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD FEB PY 2005 VL 87A IS 2 BP 310 EP 314 DI 10.2106/JBJS.D.01779 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 896SS UT WOS:000226954400011 PM 15687152 ER PT J AU Joseph, K Avallone, J Difazio, M AF Joseph, K Avallone, J Difazio, M TI Paroxysmal tonic upgaze and partial tetrasomy of chromosome 15: A novel genetic association SO JOURNAL OF CHILD NEUROLOGY LA English DT Article; Proceedings Paper CT 31st Annual Meeting of the Child-Neurology-Society CY OCT 09-12, 2002 CL WASHINGTON, D.C. SP Child Neurol Soc ID PARTIAL TRISOMY; DOWNWARD GAZE; CHILDHOOD; ATAXIA; 15Q AB Paroxysmal tonic upgaze of childhood is an eye movement abnormality characterized by periodic episodes of conjugate upward eye deviation. Although the spectrum of paroxysmal tonic upgaze has broadened considerably, a specific pathophysiology has not been elucidated. We report an infant with paroxysmal tonic upgaze who presented to his pediatrician with associated hypotonia and gross motor delay. High-resolution chromosome analysis demonstrated a supernumerary dicentric bisatellited marker chromosome. Analysis revealed partial tetrasomy of 15q. Given the significant amount of euchromatin demonstrated, it is likely that the chromosomal abnormalities are causative for the constellation of manifestations in this patient. To date, a specific genetic abnormality has not been associated with paroxysmal tonic upgaze. The finding of a genetic association with paroxysmal tonic upgaze might help characterize the substrate for ophthalmologic manifestations. Further study in this chromosomal region in patients with paroxysmal tonic upgaze is warranted. C1 Walter Reed Army Med Ctr, Dept Neurol, Child Neurol Serv, Washington, DC 20307 USA. Natl Naval Med Res Inst, Dept Ophthalmol, Bethesda, MD USA. RP Joseph, K (reprint author), Walter Reed Army Med Ctr, Dept Neurol, Child Neurol Serv, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM krjoseph1@hotmail.com NR 20 TC 7 Z9 7 U1 0 U2 0 PU B C DECKER INC PI HAMILTON PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 0883-0738 J9 J CHILD NEUROL JI J. Child Neurol. PD FEB PY 2005 VL 20 IS 2 BP 165 EP 168 DI 10.1177/08830738050200021601 PG 4 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 907UA UT WOS:000227742300020 PM 15794190 ER PT J AU Breaux, A Cochrane, S Evens, J Martindale, M Pavlik, B Suer, L Benner, D AF Breaux, A Cochrane, S Evens, J Martindale, M Pavlik, B Suer, L Benner, D TI Wetland ecological and compliance assessments in the San Francisco bay region, california, USA SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE wetlands; wetland assessments; compensatory mitigation projects; clean water act; San Francisco; California ID COMPENSATORY MITIGATION AB The San Francisco Bay Region of the California Regional Water Quality Control Board (SFB CRWQCB) and the San Francisco District of the US Army Corps of Engineers (US ACOE) are looking for an expeditious means to determine whether regulated wetland projects produce ecologically valuable systems and remain in compliance with their permits (i.e. fulfill their legal requirements) until project completion. A study was therefore undertaken in which 20 compensatory wetland mitigation projects in the San Francisco Bay Region were reviewed and assessed for both permit compliance and habitat function, and this was done using a rapid assessment method adapted for this purpose. Thus, in addition to determining compliance and function, a further goal of this study was to test the efficacy of the assessment method, which, if useful, could be applied not only to mitigation projects, but also to restoration projects and natural wetland systems. Survey results suggest that most projects permitted 5 or more years ago are in compliance with their permit conditions and are realizing their intended habitat functions. The larger restoration sites or those situated between existing wetland sites tend to be more successful and offer more benefits to wildlife than the smaller isolated ones. These results are consistent with regulatory experience suggesting that economies of scale could be realized both with (1) large scale regional wetland restoration sites, through which efforts are combined to control invasive species and share costs, and (2) coordinated efforts by regulatory agencies to track project information and to monitor the increasing number and size of mitigation and restoration sites. In regard to the assessment methods, we find that their value ties in providing a consistent protocol for evaluations, but that the ultimate assessment will rely heavily on professional judgment, regulatory experience, and the garnering of pre-assessment information. (C) 2004 Elsevier Ltd. All rights reserved. C1 Calif Reg Water Qual Control Board, Watershed Div, Oakland, CA 94612 USA. Frost Cochrane inc, Oakland, CA 94612 USA. Avocet Res Associates, Point Reyes Stn, CA 94956 USA. USA, Army Corps Engn, San Francisco, CA 94105 USA. BMP Ecosci, San Francisco, CA 94014 USA. RP Breaux, A (reprint author), Calif Reg Water Qual Control Board, Watershed Div, 1515 Clay St,Suite 1400, Oakland, CA 94612 USA. EM Abreaux@waterboards.ca.gov NR 20 TC 18 Z9 24 U1 0 U2 18 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD FEB PY 2005 VL 74 IS 3 BP 217 EP 237 DI 10.1016/j.jenvman.2004.08.017 PG 21 WC Environmental Sciences SC Environmental Sciences & Ecology GA 900FU UT WOS:000227201600003 PM 15644262 ER PT J AU Brustoski, K Moller, U Kramer, M Petelski, A Brenner, S Palmer, DR Bongartz, M Kremsner, PG Luty, AJF Krzych, U AF Brustoski, K Moller, U Kramer, M Petelski, A Brenner, S Palmer, DR Bongartz, M Kremsner, PG Luty, AJF Krzych, U TI IFN-gamma and IL-10 mediate parasite-specific immune responses of cord blood cells induced by pregnancy-associated Plasmodium falciparum malaria SO JOURNAL OF IMMUNOLOGY LA English DT Article ID REGULATORY T-CELLS; HUMAN DENDRITIC CELLS; INTERLEUKIN (IL)-10; CYTOKINE PRODUCTION; LEISHMANIA-MAJOR; DOWN-REGULATION; NEWBORN MICE; HELPER-CELL; IN-VITRO; EXPRESSION AB Available evidence suggests that immune cells from neonates born to mothers with placental Plasmodium falciparum (Pf) infection are sensitized to parasite Ag in utero but have reduced ability to generate protective Th1 responses. In this study, we detected Pf Ag-specific IFN-gamma(+) T cells in cord blood from human neonates whose mothers had received treatment for malaria or who had active placental Pf infection at delivery, with responses being significantly reduced in the latter group. Active placental malaria at delivery was also associated with reduced expression of monocyte MHC class I and II in vivo and following short term in vitro coculture with Pf Ag compared with levels seen in neonates whose mothers had received treatment during pregnancy. Given that APC activation and Th1 responses are driven in part by IFN-gamma and down-regulated by IL-10, we examined the role of these cytokines in modulating the Pf Ag-specific immune responses in cord blood samples. Exogenous recombinant human IFN-gamma and neutralizing anti-human IL-10 enhanced T cell IFN-gamma production, whereas recombinant human IFN-gamma,y also restored Mile class I and II expression on monocytes from cord blood mononuclear cells cocultured with Pf Ag. Accordingly, active placental malaria at delivery was associated with increased frequencies of Pf Ag-specific IL-10(+)CD4(+) T cells in cord blood mononuclear cell cultures from these neonates. Generation and maintenance of IL-10(+) T cells in utero may thus contribute to suppression of APC function and Pf Ag-induced Th1 responses in newborns born to mothers with placental malaria at delivery, which may increase susceptibility to infection later in life. C1 Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. Univ Tubingen, Inst Trop Med, Dept Parasitol, Tubingen, Germany. Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon. RP Krzych, U (reprint author), Walter Reed Army Inst Res, Dept Immunol, Bldg 503,Room 3W50,503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Urszula.Krzych@na.amedd.army.mil FU NIAID NIH HHS [R03AI43411-02] NR 55 TC 40 Z9 43 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD FEB 1 PY 2005 VL 174 IS 3 BP 1738 EP 1745 PG 8 WC Immunology SC Immunology GA 891HG UT WOS:000226571300075 PM 15661939 ER PT J AU Edghill-Smith, Y Bray, M Whitehouse, CA Miller, D Mucker, E Manischewitz, J King, LR Robert-Guroff, M Hryniewicz, A Venzon, D Meseda, C Weir, J Nalca, A Livingston, V Wells, J Lewis, MG Huggins, J Zwiers, SH Golding, H Franchini, G AF Edghill-Smith, Y Bray, M Whitehouse, CA Miller, D Mucker, E Manischewitz, J King, LR Robert-Guroff, M Hryniewicz, A Venzon, D Meseda, C Weir, J Nalca, A Livingston, V Wells, J Lewis, MG Huggins, J Zwiers, SH Golding, H Franchini, G TI Smallpox vaccine does not protect Macaques with AIDS from a lethal Monkeypox virus challenge SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Trans-Natl Institutes of Health/United States Food and Drug Administration Intramural Biodefense Symposium CY APR 22-23, 2004 CL Bethesda, MD ID EXPRESSION; MVA AB It is unknown whether smallpox vaccination would protect human immunodeficiency virus type 1 (HIV-1) infected individuals, because helper CD4(+) cells, the targets of HIV-1 infection, are necessary for the induction of both adaptive CD8(+) cell and B cell responses. We have addressed this question in macaques and have demonstrated that, although smallpox vaccination is safe in immunodeficient macaques when it is preceded by immunization with highly attenuated vaccinia strains, the macaques were not protected against lethal monkeypox virus challenge if their CD4(+) cell count was <300 cells/mm(3). The lack of protection appeared to be associated with a defect in vaccinia-specific immunoglobulin (Ig) switching from IgM to IgG. Thus, vaccination strategies that bypass CD4(+) cell help are needed to elicit IgG antibodies with high affinity and adequate tissue distribution and to restore protection against smallpox in severely immunocompromised individuals. C1 NCI, Anim Models & Retroviral Vaccines Sect, Bethesda, MD 20892 USA. NCI, Immune Biol Retroviral Infect Sect, Bethesda, MD 20892 USA. NCI, Biostat & Data Management Sect, Bethesda, MD 20892 USA. NIAID, Biodef Clin Res Branch, Off Clin Res, Bethesda, MD 20892 USA. US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. So Res Inst, Frederick, MD USA. RP Franchini, G (reprint author), NCI, Anim Models & Retroviral Vaccines Sect, 41-D804, Bethesda, MD 20892 USA. EM franchig@mail.nih.gov RI Venzon, David/B-3078-2008 FU NIAID NIH HHS [N01-AI-15451] NR 18 TC 47 Z9 49 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 1 PY 2005 VL 191 IS 3 BP 372 EP 381 DI 10.1086/427265 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 885BH UT WOS:000226130500008 PM 15633096 ER PT J AU Webb, RE Leslie, DM Lochmiller, RL Masters, RE AF Webb, RE Leslie, DM Lochmiller, RL Masters, RE TI Impact of food supplementation and methionine on high densities of cotton rats: Support of the amino-acid-quality hypothesis? SO JOURNAL OF MAMMALOGY LA English DT Article DE amino-acid nutrition; food supplementation; hispid cotton rats; methionine; Oklahoma; population response; Signiodon hispidus ID WILD HOUSE MICE; SIGMODON-HISPIDUS; MICROTUS-TOWNSENDII; POPULATION-DYNAMICS; PEROMYSCUS-LEUCOPUS; FIELD EXPERIMENT; NUTRITIONAL-REQUIREMENTS; TAMIASCIURUS-DOUGLASII; CENTRAL ILLINOIS; PRAIRIE VOLE AB Considerable research supports the tenet that quantity and quality of food limit vertebrate populations. We evaluated predictions that increased availabilities of food and the essential amino acid methionine were related to population limitation of the hispid cotton rat (Sigmodon hispidus). Effects of supplemental food and methionine on density, survival, and reproductive parameters of wild cotton rats were assessed in north-central Oklahoma in 1998-1999. Twelve enclosed groups of 16 adult cotton rats each (8 male, 8 female) were randomly assigned to either no supplementation (control), supplementation with a mixed ration that had methionine at slightly below maintenance levels (0.20%), or a methionine-enhanced mixed ration (1.20%). In general, densities of cotton rats were twice as high and were sustained longer with dietary supplementation, and methionine-supplemented populations maintained the highest densities. Treatment effects on survival depended on time of year, with higher survival in supplemented enclosures in October and November. Per capita recruitment was highest with methionine-enhanced food. Treatment effects on proportions of overall and female cotton rats in reproductive condition depended on sampling date, but males were most reproductively active with methionine supplementation. Methionine supplementation resulted in an earlier and longer reproductive season. Density-dependent and density-independent factors no doubt interplay to determine population dynamics of cotton rats, but our results suggest that methionine plays a role in the population dynamics of wild cotton rats, apparently by enhancing overall density, recruitment, and reproductive activity of males. C1 Oklahoma State Univ, Dept Zool, Stillwater, OK 74078 USA. Oklahoma State Univ, Oklahoma Cooperat Fish & Wildlife Res Unit, US Geol Survey, Stillwater, OK 74078 USA. Oklahoma State Univ, Dept Forestry, Stillwater, OK 74078 USA. Oklahoma State Univ, Oklahoma Cooperat Fish & Wildlife Res Unit, Stillwater, OK 74078 USA. RP Webb, RE (reprint author), ATZR TRL, Land Condit Trend Anal Coordinat, Bldg 2583,Curie Rd, Ft Sill, OK 73503 USA. EM raymond.webb@sill.army.mil NR 75 TC 8 Z9 9 U1 1 U2 1 PU ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0022-2372 J9 J MAMMAL JI J. Mammal. PD FEB PY 2005 VL 86 IS 1 BP 46 EP 55 DI 10.1644/1545-1542(2005)086<0046:IOFSAM>2.0.CO;2 PG 10 WC Zoology SC Zoology GA 898ST UT WOS:000227097200007 ER PT J AU Kang, BW Crosta, GF Stenhouse, PJ Sung, CM AF Kang, BW Crosta, GF Stenhouse, PJ Sung, CM TI Microscopy and quantitative morphology of aluminum silicate nanoparticles grown on organic templates SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article DE biomimetic synthesis; image classification; morphological descriptors AB Biomimetic synthesis of ceramic materials is increasing in popularity because it offers many advantages . In this work, aluminum silicate nanoparticles were obtained on a self-assembled organic multilayer at near room temperature (30 <= T <= 50 degrees C) and at atmospheric pressure. Morphological cc and microanalytical characterization was carried out by means of transmission electron microscopy and subsequent image analysis. The roles of some process parameters such as template type, reactant concentration, [Al]:[Si] molar ratio, number of initiation steps (IS) of mineralization, and reaction time (rt) were assessed by comparing images, diffraction patterns, and EDX spectra. Generally, the Si-rich phase exhibited higher crystallinity, whereas the Al-rich phase was mostly amorphous. Crystal structure resulted with rt >= 4 days for template-grown materials. Images of materials obtained at T = 50 degrees C, rt = 3 days, and 1 <= IS <= 4 were further analyzed by "spectrum enhancement," an algorithm based on the Fourier transform. Morphological indicators were extracted from suitably processed power spectral densities, a correlation matrix was formed, and multivariate statistics was carried out. Visual differences in nanoaggregate morphology were quantitatively translated. Materials were ranked by the spatial uniformity of nanoparticle distribution: the most uniform aggregates were those grown on templates by IS >= 2. Univariate statistics validated the conclusion: the particles of those same materials had a narrower size distribution and sharper edges. This last property has been ascribed to crystalline structure, independently demonstrated by diffraction patterns. C1 Univ Massachusetts, Ctr Adv Mat, Lowell, MA USA. Univ Milan Bicocca, Dept Environm Sci, I-20126 Milan, Italy. USA, Natick Soldier Ctr, Natick, MA USA. RP Crosta, GF (reprint author), Univ Massachusetts, Ctr Adv Mat, Lowell, MA USA. NR 12 TC 4 Z9 4 U1 0 U2 2 PU AMER SCIENTIFIC PUBLISHERS PI STEVENSON RANCH PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA SN 1533-4880 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD FEB PY 2005 VL 5 IS 2 BP 334 EP 345 DI 10.1166/jnn.2005.029 PG 12 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 908KO UT WOS:000227786100025 PM 15853157 ER PT J AU Williams, AJ Hartings, JA Lu, XCM Rolli, ML Dave, JR Tortella, FC AF Williams, AJ Hartings, JA Lu, XCM Rolli, ML Dave, JR Tortella, FC TI Characterization of a new rat model of penetrating ballistic brain injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE ballistic; bullet wound; head injury; penetrating; rat; trauma ID FOCAL CEREBRAL-ISCHEMIA; GUNSHOT WOUNDS; HEAD-INJURY; QUANTITATIVE ELECTROENCEPHALOGRAPHY; INTRACEREBRAL HEMORRHAGE; NEUROBEHAVIORAL OUTCOMES; EPILEPTIFORM DISCHARGES; SUBARACHNOID SPACE; SPREADING ISCHEMIA; MISSILE INJURIES AB Penetrating brain injury (PBI) is a leading cause of mortality and morbidity in modern warfare and accounts for a significant number of traumatic brain injuries worldwide. Here we characterize the pathophysiology of a new rat model of PBI that simulates the large temporary cavity caused by energy dissipation from a penetrating bullet round. Male Sprague-Dawley rats (250-300 g) were subjected to a simulated ballistic wound to the right frontal hemisphere implemented by an inflatable penetrating probe. Three levels of injury severity were compared to control animals. Neurological and physiological outcome was assessed over a 3-day recovery period and brain tissue collected at 72 h for histopathological evaluation. Brain-injured regions included the ipsilateral frontal cortex and striatum with volumetric increases in intracranial hemorrhage (5-18 mm(3)) and lesion size (9-86 mm3) related to severity. Similarly, hemispheric swelling increased (3-14%) following PBI, associated, ated with a significant rise in intracranial pressure. Astrogliosis was present in regions adjacent to the core-injury along with microglial and leukocyte infiltration. Injury remote to the lesion was observed in the cerebral peduncle that may have accounted, in part, for observed neurological deficits. Neurological and balance beam testing revealed sensorimotor deficits that persisted through 72 h. Severe electroencephalographic disturbances included the occurrence of cortical spreading depression, slow-waves, and brain seizure activity. In conclusion, this rat PBI model replicates diverse, salient features of clinical PBI pathology, generates reproducible and quantifiable measures of outcome, and is scalable by injury severity, rendering it an attractive vehicle for experimental brain trauma research. C1 Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. RP Williams, AJ (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, 503 Robert Grant Ave,Rm 2A40, Silver Spring, MD 20910 USA. EM anthony.williams@na.amedd.army.mil NR 65 TC 75 Z9 77 U1 0 U2 4 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD FEB PY 2005 VL 22 IS 2 BP 313 EP 331 DI 10.1089/neu.2005.22.313 PG 19 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 900XU UT WOS:000227248400010 PM 15716636 ER PT J AU Povich, T Xin, J AF Povich, T Xin, J TI A numerical study of the light bullets interaction in the (2+1) sine-Gordon equation SO JOURNAL OF NONLINEAR SCIENCE LA English DT Article ID EVOLUTION AB The propagation and interaction in more than one space dimension of localized pulse solutions (so-called light bullets) to the sine-Gordon [SG] equation is studied both asymptotically and numerically. Similar solutions and their resemblance to solitons in integrable systems were observed numerically before in vector Maxwell systems. The simplicity of SG allows us to perform an asymptotic analysis of counterpropagating pulses, as well as a fully resolved computation over rectangular domains. Numerical experiments are carried out on single pulse propagation and on two pulse collision under different orientations. The particle nature, as known for solitons, persists in these two space dimensional solutions as long as the amplitudes of initial data range in a finite interval, similar to the conditions on the vector Maxwell systems. C1 US Mil Acad, Dept Math Sci, W Point, NY 10996 USA. Univ Texas, Dept Math, Austin, TX 78712 USA. Univ Texas, ICES, Austin, TX 78712 USA. RP Povich, T (reprint author), US Mil Acad, Dept Math Sci, W Point, NY 10996 USA. EM at9970@usma.edu; jxin@math.utexas.edu NR 10 TC 4 Z9 4 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0938-8974 J9 J NONLINEAR SCI JI J. Nonlinear Sci. PD FEB PY 2005 VL 15 IS 1 BP 11 EP 25 DI 10.1007/s00332-003-0588-y PG 15 WC Mathematics, Applied; Mechanics; Physics, Mathematical SC Mathematics; Mechanics; Physics GA 914MV UT WOS:000228232800002 ER PT J AU Mathieu, JE Heffner, TS Goodwin, GF Cannon-Bowers, JA Salas, E AF Mathieu, JE Heffner, TS Goodwin, GF Cannon-Bowers, JA Salas, E TI Scaling the quality of teammates' mental models: equifinality and normative comparisons SO JOURNAL OF ORGANIZATIONAL BEHAVIOR LA English DT Article ID PERFORMANCE; KNOWLEDGE; ENVIRONMENTS; FRAMEWORK; BEHAVIOR; TESTS; WORK AB We tested the impact of teammates' team and task mental model sharedness on team processes and performance using 70 undergraduate teams that completed a series of missions on a PC-based flight simulator. Moreover, we considered how the quality of mental models might moderate such relationships. Team processes were found to partially mediate the relationship between task mental model sharedness and team performance. Although team mental model sharedness failed to exhibit a significant linear relationship with team processes or performance, it did evidence a multiplicative relationship as moderated by the quality of those models. Team processes and performance were better among teams sharing higher-quality team mental models than among teams evidencing less sharedness or who had lower-quality models. Again, team processes partially mediated these relationships. Results are discussed in terms of the equifinality of mental model quality and applications to various team environments. Copyright (C) 2005 John Wiley Sons, Ltd. C1 Univ Connecticut, Storrs, CT 06269 USA. USA, Res Inst Behav & Social Sci, Alexandria, VA USA. Univ Cent Florida, Orlando, FL 32816 USA. RP Mathieu, JE (reprint author), Univ Connecticut, 2100 Hillside Rd, Storrs, CT 06269 USA. EM JMathieu@businesss.uconn.edu OI Cannon-Bowers, Janis/0000-0003-2154-4456 NR 39 TC 133 Z9 140 U1 4 U2 29 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0894-3796 J9 J ORGAN BEHAV JI J. Organ. Behav. PD FEB PY 2005 VL 26 IS 1 BP 37 EP 56 DI 10.1002/job.296 PG 20 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA 896RX UT WOS:000226952300003 ER PT J AU Moore, JH Goss, DL Baxter, RE DeBerardino, TM Mansfield, LT Fellows, DW Taylor, DC AF Moore, JH Goss, DL Baxter, RE DeBerardino, TM Mansfield, LT Fellows, DW Taylor, DC TI Clinical diagnostic accuracy and magnetic resonance imaging of patients referred by physical therapists, orthopaedic surgeons, and nonorthopaedic providers SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE diagnostic agreement; direct access; primary care ID KNEE; PRACTITIONERS AB Study Design: Nonexperimental, retrospective design. Objectives: This study was designed to compare clinical diagnostic accuracy (CDA) between physical therapists (PTs), orthopaedic surgeons (OSs), and nonorthopaedic providers (NOPs) at Keller Army Community Hospital on patients with musculoskeletal injuries (MSI) referred for magnetic resonance imaging (MRI). Background: US Army PTs are frequently the first credentialed providers privileged to examine and diagnose patients with musculoskeletal injuries. Physical therapists assigned at Keller Army Community Hospital have also been credentialed with privileges to order MRI studies for several years. Methods and Measures: To reduce provider bias, a retrospective analysis was performed on 560 patients referred for MRI over an 18-month period. An electronic review of each patient's radiological profile was performed to assess agreement between clinical diagnosis and MRI findings. Data analyses were performed through descriptive statistics and contingency tables. Results: Analysis on agreement between clinical diagnosis and MRI findings produced a CDA of 74.5% (108/145) for PTs, 80.8% (139/172) for OSs, and 35.4% (86/243) for NOPs. There was a significant difference in CDA between PTs and NOPs (P<.001), and between OSs and NOPs (P<.001). There was no difference in CDA between PTs and OSs (P>.05). Conclusions: Clinical diagnostic accuracy by PTs and OSs on patients with musculoskeletal injuries was significantly greater than for NOPs, with no difference noted between PTs and OSs. C1 67th Combat Support Hosp, Sports Med Serv, Tikrit, Iraq. USA, Hlth Clin, Stuttgart, Germany. Irwin Army Community Hosp, Ft Riley, KS USA. Keller Army Community Hosp, Serv Radiol, W Point, NY USA. Brooke Army Med Ctr, Ft Sam Houston, TX USA. RP Moore, JH (reprint author), USA, Baylor Univ Doctoral Program Phys Therapy, Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. EM josef.moore@us.army.mil OI DeBerardino, Thomas/0000-0002-7110-8743 NR 10 TC 49 Z9 50 U1 0 U2 5 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD FEB PY 2005 VL 35 IS 2 BP 67 EP 71 PG 5 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 898UY UT WOS:000227102900006 PM 15773564 ER PT J AU Insko, CA Kirchner, JL Pinter, B Efaw, J Wildschut, T AF Insko, CA Kirchner, JL Pinter, B Efaw, J Wildschut, T TI Interindividual-intergroup discontinuity as a function of trust and categorization: The paradox of expected cooperation SO JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY LA English DT Article ID INDIVIDUAL-GROUP DISCONTINUITY; PRISONERS-DILEMMA GAME; SANCTIONING SYSTEM; SOCIAL DILEMMAS; UNITED-STATES; PUBLIC-GOODS; FEAR; REDUCTION; PROVISION; BEHAVIOR AB Two experiments used a 3-choice variation of the prisoner's dilemma game to explore the paradoxical implications of expected cooperation of other groups and individuals for competitiveness and cooperativeness. Experiment 1 found that an experimental manipulation of opponent trustworthiness influenced the tendency of both groups and individuals to cooperate but had no significant effect on the tendency of groups and individuals to compete-possibly because of the perceived unfairness of competing with a trustworthy other. Experiment 2 found that an experimental manipulation of categorization increased the tendency of same-category groups and individuals to cooperate (as in Experiment 1) and also increased the tendency of same-category groups, but not individuals, to compete (unlike in Experiment 1). It was further found that the tendency of same-category groups to compete more than same-category individuals was relatively stronger for participants high in guilt proneness. C1 Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA. Penn State Univ, Altoona Coll, Dept Psychol, University Pk, PA 16802 USA. US Mil Acad, W Point, NY 10996 USA. Univ Southampton, Dept Psychol, Southampton SO9 5NH, Hants, England. RP Insko, CA (reprint author), Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA. FU NIMH NIH HHS [MH 53258] NR 71 TC 49 Z9 50 U1 0 U2 11 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0022-3514 J9 J PERS SOC PSYCHOL JI J. Pers. Soc. Psychol. PD FEB PY 2005 VL 88 IS 2 BP 365 EP 385 DI 10.1037/0022-3514.88.2.365 PG 21 WC Psychology, Social SC Psychology GA 891MO UT WOS:000226585400009 PM 15841864 ER PT J AU Parker, AP Troiano, E Underwood, JH AF Parker, AP Troiano, E Underwood, JH TI Stresses within compound tubes comprising a steel liner and an external carbon-fiber wrapped laminate SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT ASME Pressure Vessels and Piping Division Conference CY JUL 25-29, 2004 CL San Diego, CA SP ASME AB There is increasing interest in techniques that permit weight reduction of thick cylinders, particularly gun barrels. The method examined within this paper involves the external wrapping of a carbon fiber-based laminate jacket around a steel liner Various design options are examined, e.g., prior autofrettage of a steel liner followed by external tension wrapping and benign wrapping of a stress-free steel liner,followed by autofrettage of the assembly. Outcomes include optimum overstrain and machining of the steel liner, identification of a potential "crushing" failure mode due to radial compressive stresses and techniques for application of tension wrapping which optimize hoop stress within the composite jacket. Finally, possible combinations of fiber orientations are discussed. C1 Cranfield Univ, Royal Mil Coll Sci, Swindon SN6 8LA, Wilts, England. USA, Armament RD&E Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Parker, AP (reprint author), Cranfield Univ, Royal Mil Coll Sci, Swindon SN6 8LA, Wilts, England. EM tony_parker@tesco.net NR 8 TC 2 Z9 2 U1 2 U2 3 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD FEB PY 2005 VL 127 IS 1 BP 26 EP 30 DI 10.1115/1.1845472 PG 5 WC Engineering, Mechanical SC Engineering GA 917JE UT WOS:000228456100005 ER PT J AU Zhang, SS Ervin, MH Foster, DL Xu, K Jow, TR AF Zhang, SS Ervin, MH Foster, DL Xu, K Jow, TR TI Fabrication and evaluation of a polymer Li-ion battery with microporous gel electrolyte SO JOURNAL OF SOLID STATE ELECTROCHEMISTRY LA English DT Article DE microporous gel electrolyte; microporous membrane; gel polymer electrolyte; phase inversion; polymer Li-ion battery ID LITHIUM BATTERIES; CELLS; MEMBRANES; PERFORMANCE AB This paper introduces an easy method for the fabrication of polymer Li-ion batteries with microporous gel electrolyte ( MGE). The MGE is a multiphase electrolyte, which is composed of liquid electrolyte, gel electrolyte, and polymer matrix. The MGE not only has high ionic conductivity and good adhesion to the electrodes at low temperatures, but also retains good mechanical strength at elevated temperatures. Therefore, the MGE batteries are able to operate over a wide temperature range. During battery fabrication, the MGE is formed in situ by introducing liquid electrolyte into a swellable microporous polymer membrane and then heating or cycling the battery. In this work, the chemical compatibility of MGE with metal lithium during 60degreesC storage and with LiMn2O4 cathode during cycling was studied. In addition, graphite/MGE/LiMn2O4 Li-ion batteries were made and evaluated. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 19 TC 13 Z9 15 U1 2 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1432-8488 J9 J SOLID STATE ELECTR JI J. Solid State Electrochem. PD FEB PY 2005 VL 9 IS 2 BP 77 EP 82 DI 10.1007/s10008-004-0569-y PG 6 WC Electrochemistry SC Electrochemistry GA 895WW UT WOS:000226895800002 ER PT J AU Watson, S AF Watson, S TI The other war of 1812: The patriot war and the American invasion of Spanish East Florida. SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSOC PI ATHENS PA UNIV GEORGIA, HISTORY DEPT, ATHENS, GA 30602 USA SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD FEB PY 2005 VL 71 IS 1 BP 147 EP 149 PG 3 WC History SC History GA 894DI UT WOS:000226770200013 ER PT J AU Watson, S AF Watson, S TI Coacoochee's bones: A seminole saga. SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSOC PI ATHENS PA UNIV GEORGIA, HISTORY DEPT, ATHENS, GA 30602 USA SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD FEB PY 2005 VL 71 IS 1 BP 147 EP 149 PG 3 WC History SC History GA 894DI UT WOS:000226770200014 ER PT J AU Cohen, SP Williams, S Kurihara, C Griffith, S Larkin, TM AF Cohen, SP Williams, S Kurihara, C Griffith, S Larkin, TM TI Nucleoplasty with or without intradiscal electrothermal therapy (IDET) as a treatment for lumbar herniated disc SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES LA English DT Article DE intradiscal electrothermal therapy; low back pain; lumbar disc herniation; nucleoplasty; radiculopathy; sciatica ID CHYMOPAPAIN; DISCOGRAPHY; SURGERY; PAIN AB Background and Objective: In industrialized societies, the prevalence of radicular low back pain has exploded in recent years. The growing economic and personal costs of this challenging entity have led to the development of a wide array of new treatments, ranging from pharmacotherapy with neuropathic medications to open surgical treatment. Among the therapeutic options to emerge are a plethora of minimally invasive treatments aimed at removing nuclear material and lowering intradiscal pressure through devices inserted percutaneously into intervertebral discs. Yet there is a compelling lack of clinical evidence to support the use of these procedures. This study was undertaken to determine the treatment outcomes of 16 consecutive patients with lumbar radicular pain secondary to a herniated disc who underwent nucleoplasty as their primary therapy. Methods: Included in this series were nine patients with significant axial back pain, sitting intolerance, and positive discography who also underwent intradiscal electrothermal therapy (IDET). Among the 7 patients who only had nucleoplasty, 4 had 2 discs treated and 3 had 1 disc. In the 9 patients who also had IDET, 6 had I disc treated and 3 had 2 discs treated. Of the 32 total disc treatments, 20 were at L5-S1, 10 were at L4-5 and 2, one each for IDET and nucleoplasty, were at L3-4. Results: In the overall cohort, the average Visual Analogue Scale (VAS) pain score decreased from 6.7 to 5.6 at a mean follow-up of 9 months. In the seven patients who underwent only nucleoplasty, the mean VAS score decreased from 6.0 to 4.8. Only one patient reported a greater than or equal to50% reduction in pain score. Conclusions: We conclude that with use of the present selection criteria, nucleoplasty is not an effective long-term treatment for lumbar radiculopathy, either alone or with IDET. Before conducting future clinical trials, we recommend modifying these criteria to include only those patients with small (<6-mm) contained disc herniations whose annular integrity is documented by computed tomography discography and corresponding radicular symptoms confirmed by either selective nerve root blocks or electromyography and nerve conduction studies. C1 Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Pain Management Ctr, Baltimore, MD 21287 USA. Walter Reed Army Med Ctr, Pain Management Ctr, Dept Anesthesiol, Washington, DC 20307 USA. RP Cohen, SP (reprint author), Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Pain Management Ctr, Blalock 1415,600 N Wolfe St, Baltimore, MD 21287 USA. EM spc5_2000@yahoo.com NR 27 TC 22 Z9 25 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1536-0652 J9 J SPINAL DISORD TECH JI J. Spinal Disord. Tech. PD FEB PY 2005 VL 18 SU 1 BP S119 EP S124 DI 10.1097/01.bsd.0000127823.54485.3f PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 900JU UT WOS:000227212000018 PM 15699797 ER PT J AU Kuklo, TR Lehman, RA Lenke, LG AF Kuklo, TR Lehman, RA Lenke, LG TI Structures at risk following anterior instrumented spinal fusion for thoracic adolescent idiopathic scoliosis SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES LA English DT Article ID PERIOPERATIVE COMPLICATIONS; AORTIC RUPTURE; LUMBAR SPINE; SURGERY; DEVICE; STABILIZATION AB Objectives: With the increasing popularity of anterior instrumented spinal fusion for adolescent idiopathic scoliosis, there has also been a rising concern over the proximity of the descending aorta to the screw tips and the possibility of vessel wall erosion over time. This computed tomography (CT) study attempts to define the relative position of the thoracic aorta and other vital structures to the spine (preoperatively) and to the projected instrumentation (postoperatively) by level and curve magnitude in deformity patients. Methods: Twenty consecutive patients (17 female, 3 male) with an average age of 14.5 years (range 12.4-18.5 years) and a right main thoracic/Lenke 1 curve (average 55.2, range 50-66degrees) underwent preoperative and postoperative CT scanning as part of their planned open anterior spinal fusion with instrumentation. All images were analyzed for proximity (distance from the midvertebral body) and position to (as defined relative to the center of the vertebral body in the axial plane) the spine preoperatively and the projecting screw tip postoperatively. As a control, 10 age-matched nondeformity thoracic CT scans were analyzed to assess the relative position of the thoracic aorta to the vertebral bodies by level. Preoperative and postoperative plain radiographs were also analyzed for curve magnitude, correction, and fusion levels to assess the possible effect of these variables on the various thoracic structures. Results: The postoperative curve magnitude averaged 26.9 (range 17-40degrees; 51 % correction) using 151 screws (7.5 screws/patient) and an average follow-up of 4.1 years (range 3.2-7.0 years). Screw-to-spinal-canal distance averaged 5.3 mm (range 3.5-8.2 mm) at an average of +4.5degrees (range -11degrees to +15degrees) from the coronal axis. Screw tip extrusion (distance beyond the far cortex) averaged 2.8 mm (0-5 mm). The trachea, azygous vein, esophagus, and lungs/pleura were not found to be at risk from screw penetration. The postoperative screw-tip-to-descending-aorta distance varied by vertebra level, with the periapical and distal screws being positioned closer to the aorta (1.6-2.4 mm) (P < 0.05). Additionally, 23 of 151(15%) screws were thought to be adjacent (less than or equal to2 mm) to the aorta. This includes 4 of 60 (7%) of the proximal screws but 6 of 40 (15%) of the periapical screws and 13 of 51 (26%) of the distal screws (P < 0.05). There were no screws compressing the aorta and no perioperative or postoperative complications. Conclusions: The course of the thoracic aorta may vary in individuals; however, in deformity patients, it generally moves from a relatively anterolateral position proximally to a posteromedial position at the apex. Distally, it moves more anteriorly. Consequently, the aorta moves closer to the screw tips both at the apex and distally, whereas the distal screws are more frequently juxtaposed to the descending aorta (P < 0.05). C1 Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA. RP Kuklo, TR (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed Surg, Washington, DC 20307 USA. EM kuklot@AOL.com NR 23 TC 29 Z9 32 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1536-0652 J9 J SPINAL DISORD TECH JI J. Spinal Disord. Tech. PD FEB PY 2005 VL 18 SU 1 BP S58 EP S64 DI 10.1097/01.bsd.0000123424.12852.75 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 900JU UT WOS:000227212000008 PM 15699806 ER PT J AU Alemany, JA Pandorf, CE Montain, SJ Castellani, JW Tuckow, AP Nindl, BC AF Alemany, JA Pandorf, CE Montain, SJ Castellani, JW Tuckow, AP Nindl, BC TI Reliability assessment of ballistic jump squats and bench throws SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE intraclass correlation coefficients; power testing; squat jump; bench throw ID PHYSICAL PERFORMANCE TESTS; INTENSITY; RESPONSES; EXERCISE; OCCURS; LOAD AB The purpose of this investigation was to determine the test-retest reliability and coefficient of variation of 2 novel physical performance tests. Ten healthy men (22.0 +/- 3.0 years, 87.0 +/- 8.0 kg, 20.0 +/- 5.0% body fat) performed 30 continuous and dynamic jump squats (JS) and bench throws (BT) on 4 separate occasions. The movements were performed under loaded conditions utilizing 30% of subject's predetermined 1 repetition maximum in the back squat and bench press. Mean power (MP; W), peak power (PP; W), mean velocity (MV; m(.)s(-1)), peak velocity (PV; m(.)s(-1)), and total work (TW; J) were assessed using a ballistic measurement system (Innervations Inc., Muncie, IN). Data were analyzed using repeated measures analysis of variance with Duncan's post hoe test when mean differences were p less than or equal to 0.05. Intraclass correlation coefficient (ICC) and within-subject coefficient of variation (CV%) were also calculated. All values are presented as mean +/- SE. BT variables were statistically similar across the 4 sessions: MP (350.0 +/- 13.9 W), PP (431.4 +/- 18.5 W) MV (1.6 +/- 0.03 m(.)s(-1)), PV (2.0 +/- 0.03 m(.)s(-1)), and TW (199.1 +/- 7.2 J). For JS, session 3 PP (1,669.8 +/- 111.2 W) was significantly greater vs. sessions 1, 2, and 4 (1,601.2 +/- 58.4 W). Session 4 MP (1,403.2 +/- 88.6 W) and MV (1.9 +/- 0.1 m(.)s(-1)) for JS were significantly lower during sessions 1, 2, and 3 (MP: 1,479.4.5 +/- 44.8 W, MV: 2.0 +/- 0.05 m(.)s(-1)). TW (834.7 +/- 24.3 J) and PV (2.2 +/- 0.04 m(.)s(-1)) were staistically similar during all sessions for JS. The CVs ranged from 3.0 to 7.6% for the BT and 3.2 to 5.7% for the JS. ICCs for MP, PP, MV, PV, and TW were 0.92, 0.95, 0.94, 0.91, and 0.95, respectively, during BT. ICCs during JS for MP, PP, MV, PV, and TW were 0.96, 0.98, 0.94, 0.94, and 0.89, respectively. The results of the current study support the use of a 30 continuous and dynamic BT protocol as a reliable upper-body physical performance test, which can be administered with minimal practice. Slightly greater variability for JS was observed, although the test had high reliability. C1 USA, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. USA, Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Nindl, BC (reprint author), USA, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. EM nindl@na.amedd.army.mil NR 19 TC 38 Z9 38 U1 1 U2 5 PU ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD FEB PY 2005 VL 19 IS 1 BP 33 EP 38 PG 6 WC Sport Sciences SC Sport Sciences GA 899MF UT WOS:000227147800007 PM 15705042 ER PT J AU Kragh, JF Bagg, MR Ward, JA Omer, GE AF Kragh, JF Bagg, MR Ward, JA Omer, GE TI Measuring medical education and curriculum during orthopedic surgical residency SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE graduate medical education measurement; residency; surgery; assessment; curriculum; academic medicine ID IN-TRAINING EXAMINATION; QUALITY AB Background. Evaluating residency programs requires objective assessment tools, but few are readily available. The purpose of this study was to measure education by correlating resident test scores with several measurements of educator performance. Materials and methods. The study group included residents and educators from a single residency program. We performed a retrospective analysis of scores from the Orthopaedic In-Training Examination collected during a 6-year period. Resident examination scores were indexed by dividing program averages by national averages to determine yearly score trends and then were correlated with educator attendance and teaching hours. Subspecialty scores were ranked to gauge residency strengths and weaknesses. Teaching hours devoted to subspecialties were compared with test scores to measure curricular emphases and to appraise teaching efficiency. Results. Yearly average examination scores were proportional to national averages (P < 0.001). However, of 3436 possible educator-score associations, only 15 scores correlated highly (r > 0.9) with educators, and only 26 were significant (P < 0.05). Trend analysis put subspecialty scores in yearly perspective. Ranking was inaccurate until scores were indexed to the national average. In 2002, the distribution of 238 teaching hours ranged from 4 to 48 h for subspecialties, and 9 of 12 subspecialties were emphasized disproportionately to the examination. Teaching efficiency varied more than 10-fold by subspecialty. Conclusions. The creation of a score index helped to identify and address imbalances between teaching hours devoted to subspecialties and resident needs as evidenced by low In-Training examination scores. The present study improved educator accountability by correlating measurements of teaching and learning. C1 Brooke Army Med Ctr, Orthopaed Serv, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. Univ New Mexico, Dept Orthopaed & Rehabil, Albuquerque, NM 87131 USA. RP Kragh, JF (reprint author), USA, Inst Surg Res, Extrem Trauma Study Branch, 3600 Chambers Ave,Bldg 3611Rm 292-1, Ft Sam Houston, TX 78234 USA. EM john.kragh@amedd.army.mil NR 17 TC 7 Z9 7 U1 1 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD FEB PY 2005 VL 123 IS 2 BP 268 EP 274 DI 10.1016/j.jss.2004.08.014 PG 7 WC Surgery SC Surgery GA 902ER UT WOS:000227337500016 PM 15680389 ER PT J AU Wolf, SE Woodside, KJ AF Wolf, SE Woodside, KJ TI Transgenic and gene knock-out techniques and burn research SO JOURNAL OF SURGICAL RESEARCH LA English DT Review DE transgenic; knock-out; burn ID PSEUDOMONAS-AERUGINOSA; LENTIVIRAL VECTORS; INJURY PRIMES; MOUSE GENOME; T-CELLS; IN-VIVO; MICE; EXPRESSION; INFECTION; TRAUMA AB The development of transgenic technology has given researchers a powerful tool to examine biological effects, and the response to injury is no exception. Techniques such as pronuclear injection, targeted homologous recombination, and CrelloxP gene excision are being used to construct animals with specific genetic designs; these are exploited to learn the role of genes in the response to severe burn. We review the construction of transgenic animals, pitfalls and benefits of this relatively new technique, and how this technique has been used in burn research. (C) 2004 Elsevier Inc. All rights reserved. C1 Univ Texas, Hlth Sci Ctr, Dept Surg, San Antonio, TX 78285 USA. Univ Texas, Dept Surg, Med Branch, Galveston, TX 77555 USA. RP Wolf, SE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM steven.wolf@amedd.army.mil OI Woodside, Kenneth/0000-0002-7495-3758; Wolf, Steven/0000-0003-2972-3440 NR 45 TC 4 Z9 4 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD FEB PY 2005 VL 123 IS 2 BP 328 EP 339 DI 10.1016/j.jss.2004.06.001 PG 12 WC Surgery SC Surgery GA 902ER UT WOS:000227337500024 PM 15680397 ER PT J AU Houtsma, AJM AF Houtsma, AJM TI A note on pure-tone masking by broadband noise under free-field and insert-phone conditions (L) SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Letter ID NOTCHED-NOISE; FREQUENCY; LEVEL AB Free-field experiments on masking of low-frequency tones by broadband noise, as reported by Fidell, et al. [J. Acoust. Soc. Am. 73, 628-638 (1983)] should, in principle, yield the same results as the recently reported insert-phone experiment by Houtsma [J. Acoust. Soc. Am. 115, 967-970 (2004)]. Indeed, if Fidell et al.'s data are converted to critical ratios and compared with the recent insert-earphone results, both turn out to be quite similar and significantly different from Hawkins and Stevens' classical critical ratio results. C1 USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Houtsma, AJM (reprint author), USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. NR 12 TC 1 Z9 1 U1 0 U2 1 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 2005 VL 117 IS 2 BP 490 EP 491 DI 10.1121/1.1841611 PG 2 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 897EN UT WOS:000226986900003 PM 15759670 ER PT J AU Ostashev, VE Wilson, DK Liu, LB Aldridge, DF Symons, NP Marlin, D AF Ostashev, VE Wilson, DK Liu, LB Aldridge, DF Symons, NP Marlin, D TI Equations for finite-difference, time-domain simulation of sound propagation in moving inhomogeneous media and numerical implementation SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID FLOW; MODEL AB Finite-difference, time-domain (FDTD) calculations are typically performed with partial differential equations that are first order in time. Equation sets appropriate for FDTD calculations in a moving inhomogeneous medium (with an emphasis on the atmosphere) are derived and discussed in this paper. Two candidate equation sets, both derived from linearized equations of fluid dynamics, are proposed. The first, which contains three coupled equations for the sound pressure, vector acoustic velocity, and acoustic density, is obtained without any approximations. The second, which contains two coupled equations for the sound pressure and vector acoustic velocity, is derived by ignoring terms proportional to the divergence of the medium velocity and the gradient of the ambient pressure. It is shown that the second set has the same or a wider range of applicability than equations for the sound pressure that have been previously used for analytical and numerical studies of sound propagation in a moving atmosphere. Practical FDTD implementation of the second set of equations is discussed. Results show good agreement with theoretical predictions of the sound pressure due to a point monochromatic source in a uniform, high Mach number flow and with Fast Field Program calculations of sound propagation in a stratified moving atmosphere. (C) 2005 Acoustical Society of America. C1 NOAA, Environm Technol Lab, Boulder, CO 80305 USA. New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. Sandia Natl Labs, Dept Geophys Technol, Albuquerque, NM 87185 USA. USA, Res Lab, White Sands Missile Range, NM 88002 USA. RP Ostashev, VE (reprint author), NOAA, Environm Technol Lab, Boulder, CO 80305 USA. RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 36 TC 67 Z9 67 U1 1 U2 17 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 2005 VL 117 IS 2 BP 503 EP 517 DI 10.1121/1.1841531 PG 15 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 897EN UT WOS:000226986900005 PM 15759672 ER PT J AU Taylor, AJ Lee, HY Grace, KA Lee, JK Sullenberger, LE AF Taylor, AJ Lee, HY Grace, KA Lee, JK Sullenberger, LE TI Relationship between diabetic status and progression of carotid atherosclerosis after the addition of extended-release niacin to statin monotherapy SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 54th Annual Scientific Session of the American-College-of-Cardiology CY MAR 06, 2005 CL Orlando, FL SP Amer Coll Cardiol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD FEB 1 PY 2005 VL 45 IS 3 SU A BP 3A EP 3A PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 894RB UT WOS:000226808200012 ER PT J AU Kolasa, MW O'Bryan, C Krasuski, R Roman-Gonzalez, J Hall, W AF Kolasa, MW O'Bryan, C Krasuski, R Roman-Gonzalez, J Hall, W TI Myocardial scar morphology as determined by magnetic resonance imaging identifies substrate for ventricular tachycardia SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 54th Annual Scientific Session of the American-College-of-Cardiology CY MAR 06, 2005 CL Orlando, FL SP Amer Coll Cardiol C1 Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD FEB 1 PY 2005 VL 45 IS 3 SU A BP 109A EP 109A PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 894RB UT WOS:000226808200475 ER PT J AU Javaheri, SP Shry, E Eckart, R Atwood, JE Grabenstein, J AF Javaheri, SP Shry, E Eckart, R Atwood, JE Grabenstein, J TI In-white blood cell scan in the assessment of myocardial inflammation in vaccinia-associated myopericarditis SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 54th Annual Scientific Session of the American-College-of-Cardiology CY MAR 06, 2005 CL Orlando, FL SP Amer Coll Cardiol C1 Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD FEB 1 PY 2005 VL 45 IS 3 SU A BP 142A EP 142A PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 894RB UT WOS:000226808200620 ER PT J AU Javaheri, SR Shry, E Eckert, R Cassimatis, D Atwood, JE Grabenstein, J AF Javaheri, SR Shry, E Eckert, R Cassimatis, D Atwood, JE Grabenstein, J TI Assessment of vaccinia-associated myopericarditis with cardiac magnetic resonance imaging SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 54th Annual Scientific Session of the American-College-of-Cardiology CY MAR 06, 2005 CL Orlando, FL SP Amer Coll Cardiol C1 Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD FEB 1 PY 2005 VL 45 IS 3 SU A BP 142A EP 142A PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 894RB UT WOS:000226808200624 ER PT J AU Lee, JC Lee, HJ Cassimatis, DC Taylor, AJ Atwood, JE AF Lee, JC Lee, HJ Cassimatis, DC Taylor, AJ Atwood, JE TI Pulsus paradoxus in obesity SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 54th Annual Scientific Session of the American-College-of-Cardiology CY MAR 06, 2005 CL Orlando, FL SP Amer Coll Cardiol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD FEB 1 PY 2005 VL 45 IS 3 SU A BP 142A EP 142A PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 894RB UT WOS:000226808200623 ER PT J AU Taylor, AJ Bindeman, J Perron, T Feuerstein, IM Brazaitis, M O'Malley, PG AF Taylor, AJ Bindeman, J Perron, T Feuerstein, IM Brazaitis, M O'Malley, PG TI Coronary calcium is independently predictive of hard CHD outcomes in a young, unselected population: 5 year outcomes from the prospective army coronary calcium SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 54th Annual Scientific Session of the American-College-of-Cardiology CY MAR 06, 2005 CL Orlando, FL SP Amer Coll Cardiol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD FEB 1 PY 2005 VL 45 IS 3 SU A BP 310A EP 310A PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 894RB UT WOS:000226808201345 ER PT J AU Clayton, JD AF Clayton, JD TI Dynamic plasticity and fracture in high density polycrystals: constitutive modeling and numerical simulation SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Article DE microcracking; microstructures; crystal plasticity; finite elements ID TUNGSTEN HEAVY ALLOYS; ADIABATIC SHEAR LOCALIZATION; ENERGY PENETRATOR MATERIALS; CVD TEXTURED TUNGSTEN; GRAIN LEVEL MODEL; STORED ENERGY; CRYSTAL PLASTICITY; BRITTLE MATERIALS; COHESIVE ZONE; STRAIN-RATE AB Presented is a constitutive framework for modeling the dynamic response of polycrystalline microstructures, posed in a thermodynamically consistent manner and accounting for finite deformation, strain rate dependence of flow stress. thermal softening. thermal expansion, heat conduction, and thermoelastic coupling. Assumptions of linear and square-root dependencies. respectively, of the stored energy and flow stresses upon the total dislocation density enable calculation of the time-dependent fraction of plastic work converted to heat energy. Fracture at grain boundary interfaces is represented explicitly by cohesive zone models. Dynamic finite element simulations demonstrate the influences of interfacial separation, random crystallographic orientation, and grain morphology on the high-rate tensile response of a realistic two-phase material system consisting of comparatively brittle pure tungsten (W) grains embedded in a more ductile matrix of tungsten-nickel iron (W-Ni-Fe) alloy. Aspects associated with constitutive modeling of damage and failure in the homogenized material system are discussed in light of the computational results. Published by Elsevier Ltd. C1 USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil RI Clayton, John/C-7760-2009 NR 88 TC 81 Z9 82 U1 4 U2 35 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-5096 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD FEB PY 2005 VL 53 IS 2 BP 261 EP 301 DI 10.1016/j.jmps.2004.06.009 PG 41 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA 891BG UT WOS:000226555700002 ER PT J AU Shah, J Moller, KD Grebel, H Sternberg, O Tobias, JM AF Shah, J Moller, KD Grebel, H Sternberg, O Tobias, JM TI Three-dimensional metallo-dielectric photonic crystals with cubic symmetry as stacks of two-dimensional screens SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID TRANSMISSION; MESHES AB Metallo-dielectric photonic crystals with cubic symmetries have been studied here both experimentally and theoretically in the millimeter wavelength region (15-60 mm). In a direct analogy to linear systems, we considered the three-dimensional lattices as a stack of two-dimensional resonating screens. The overall three-dimensional structure was introduced in the calculation through a structural phase. Such an approach proved useful in understanding the related mode propagation and guided us in a study of the transition between cubic and centered body cubic symmetries. (C) 2005 Optical Society of America. C1 New Jersey Inst Technol, Elect Imaging Ctr, Newark, NJ 07102 USA. New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. USN, Res Lab, NRC, Washington, DC 20375 USA. USA, Commun Elect Command, Ft Monmouth, NJ 07703 USA. RP New Jersey Inst Technol, Elect Imaging Ctr, Newark, NJ 07102 USA. EM grebel@njit.edu NR 20 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD FEB PY 2005 VL 22 IS 2 BP 370 EP 376 DI 10.1364/JOSAA.22.000370 PG 7 WC Optics SC Optics GA 891ND UT WOS:000226586900021 PM 15717569 ER PT J AU Parker, MV O'Donnell, SD Chang, AS Johnson, CA Gillespie, DL Goff, JM Rasmussen, TE Rich, NM AF Parker, MV O'Donnell, SD Chang, AS Johnson, CA Gillespie, DL Goff, JM Rasmussen, TE Rich, NM TI What imaging studies are necessary for abdominal aortic endograft sizing? A prospective blinded study using conventional computed tomography, aortography, and three-dimensional computed tomography SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 18th Annual Meeting of the Eastern-Vascular-Society CY APR 29-MAY 01, 2004 CL Philadelphia, PA SP Eastern Vasc Soc ID PREOPERATIVE ARTERIOGRAPHY; OPEN REPAIR; ANEURYSM; ANGIOGRAPHY; GRAFTS AB Objective: Preoperative imaging modalities for endovascular abdominal aortic aneurysm repair (EVAR) include conventional computed tomography (CT), aortography with a marking catheter, and three-dimensional computed tomography (313 CT). Although each technique has advantages, to date no study has compared in a prospective manner the reproducibility of measurements and impact on graft selection of all three modalities. The objective of this study was to determine the most useful imaging studies in planning EVAR. Methods. Twenty patients being considered for EVAR were enrolled prospectively to undergo a conventional CT scan and aortography. The CT scans were then reconstructed into 3D images using Preview Treatment Planning Software (Medical Media Systems, West Lebanon, NH). Four measurements of diameter and six of length were made from each modality in determining the proper graft for EVAR. Results: Measurements from all three modalities were reproducible with intraobserver correlation coefficients of 0.79 to 1.0 for aortography, 0.87 to 1.0 for CT, and 0.96 to 1.0 for 3D CT. Measurements between observers were also similar from each modality; interobserver correlations were 0.70 to 0.97 for aortography, 0.76 to 0.97 for CT, and 0.73 to 0.99 for 3D CT. Significant differences (P <.01) in diameter measurements were noted at D2 with aortography compared with 3D CT, whereas differences in length measurements were found between CT and 3D CT at L4 (nonaneurysmal right iliac) (P <.01). The correlation between CT and 3D CT for most length measurements was acceptable (0.63 to 1.0). Aortography for diameters correlated poorly (0.35 to 0.67) with 3D CT. When the endograft selected by aortography/CT or 3D CT alone was compared with the actual endograft used, there was agreement in 11 of 11 patients when adjusted for one size in diameter or length. Conclusion: Reproducible and comparable measures of diameter and length can be obtained by each of three imaging modalities available for endograft sizing. As a single imaging modality, 3D CT appears to have the best correlation for both diameters and lengths; however, the difference is not sufficient enough to alter endograft selection. Three-dimensional CT may be reserved for challenging aortic anatomy where small differences in measurements would affect patient or graft selection for EVAR. C1 Walter Reed Army Med Ctr, Peripheral Vasc Surg Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Washington, DC 20307 USA. RP O'Donnell, SD (reprint author), Walter Reed Army Med Ctr, Peripheral Vasc Surg Serv, Vasc Surg Clin Ward 64, Washington, DC 20307 USA. EM sean.odonnell@na.amedd.army.mil OI Gillespie, David/0000-0002-4378-9465 NR 20 TC 34 Z9 34 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD FEB PY 2005 VL 41 IS 2 BP 199 EP 205 DI 10.1016/j.jvs.2004.12.010 PG 7 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 905KK UT WOS:000227566800003 PM 15767998 ER EF