FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Morris, MJ Schwartz, DS Nohrenberg, JL Dooley, SN AF Morris, Michael J. Schwartz, Darin S. Nohrenberg, Jana L. Dooley, Sean N. TI Airway Hyperreactivity in asymptomatic military personnel SO MILITARY MEDICINE LA English DT Article ID FOLLOW-UP; BRONCHIAL HYPERRESPONSIVENESS; LONGITUDINAL POPULATION; CHILDHOOD ASTHMA; EXERCISE; UNDERDIAGNOSIS; METHACHOLINE; ADULTHOOD; SYMPTOMS AB Objectives: Asthma is frequently diagnosed in military personnel despite strict guidelines that disqualify persons with active disease or a recent history of asthma. It is generally considered incompatible with military service, because of the regular physical training, outdoor training exercises, and deployments to remote locations. The objective of this study was to determine the prevalence of airway hyperreactivity in asymptomatic military personnel, as an estimate of subclinical reactive airway disease. Methods: A prospective study of healthy, asymptomatic, military personnel with no previous history of asthma and < 1 year on active duty status was conducted. After completion of a screening questionnaire, personnel underwent baseline spirometry with a portable spirometer. Personnel with obstructive indices (based on published guidelines) and matched control subjects participated in an exercise test (1.5-mile run), with pre- and postexercise spirometry. Results: A total of 222 asymptomatic military personnel completed baseline spirometry, and 31 (14%) were found have airway obstruction. A normal matched control group of 31 military personnel and 26 personnel with obstruction performed exercise spirometry. Twenty-three percent of the participants with obstruction demonstrated increased airway hyper-reactivity after exercise, based on a reduction in forced expiratory volume at 1 second, compared with 19% of control subjects. Conclusions: Asymptomatic airway obstruction has a prevalence of 14% in young military personnel. A significant percentage of individuals also have evidence of worsening obstruction during exercise. These data suggest that screening spirometry may identify early reactive airway disease in asymptomatic individuals and should be considered as a method to identify persons predisposed to developing symptomatic asthma. C1 Brooke Army Med Ctr, Dept Med, Pulm Dis Crit Care Med Serv, Ft Sam Houston, TX 78234 USA. Army Med Dept Ctr & Sch, Dept Combat Med Training, Ft Sam Houston, TX 78234 USA. RP Morris, MJ (reprint author), Brooke Army Med Ctr, Dept Med, Pulm Dis Crit Care Med Serv, Ft Sam Houston, TX 78234 USA. NR 23 TC 8 Z9 8 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2007 VL 172 IS 11 BP 1194 EP 1197 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 232FS UT WOS:000251004300013 PM 18062396 ER PT J AU Sivan, AV Lee, T Binn, LN Gaydos, JC AF Sivan, Arijali V. Lee, Terrence Binn, Leonard N. Gaydos, Joel C. TI Adenovirus-associated acute respiratory disease in healthy adolescents and adults: A literature review SO MILITARY MEDICINE LA English DT Review ID MILITARY RECRUITS; MOLECULAR EPIDEMIOLOGY; ANTIBODY RESPONSE; VIRUS INFECTIONS; TRACT INFECTIONS; US MILITARY; PERSONNEL; INFLUENZA; OUTBREAK; ILLNESS AB Adenovirus-associated acute respiratory disease (AARD) is well documented in the U.S. military, but little information is readily available on its occurrence in other healthy populations that might also benefit from adenovirus vaccines. We reviewed publications on AARD in non-U.S. military, immunocompetent, young adults in group-living settings. Since adenovirus disease can be severe in immunocompromised and pediatric patients, we also considered AARD in health care workers. We evaluated 83 publications, published between 1950 and 2005, concerning 22 countries. Most described outbreaks in foreign military recruits and were published before 1970. More recent reports documented outbreaks in student dormitories and medical facilities. The 83 reports did not provide evidence for AARD being a serious, persistent, contemporary concern in the populations studied, nor did they identify strong interest in adenovirus vaccines. Currently availability, sensitive, molecular diagnostic teats may better define the importance of AARD in populations outside the U.S. military. C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Dept Def Global Emerging Infect Surv & Response S, Silver Spring, MD 20910 USA. RP Sivan, AV (reprint author), USA, Ctr Hlth Promot & Prevent Med, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. RI Valle, Ruben/A-7512-2013 NR 92 TC 12 Z9 12 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2007 VL 172 IS 11 BP 1198 EP 1203 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 232FS UT WOS:000251004300014 PM 18062397 ER PT J AU Morey, AF Tausch, TJ Evans, A AF Morey, Allen F. Tausch, Timothy J. Evans, Andrew TI Immediate insertion of a semirigid penile prosthesis for refractory ischemic priapism SO MILITARY MEDICINE LA English DT Article ID LOW-FLOW PRIAPISM; MANAGEMENT AB The insertion of a penile prosthesis for reduction of ischemic priapism has previously been described for cases of sickle cell disease, delayed presentation, or failure of previous shunt surgery. We report the first case of immediate insertion of a malleable prosthesis as primary surgical therapy for refractory ischemic priapism in a patient with known preexisting erectile dysfunction. We propose a novel management algorithm incorporating the acute insertion of a penile prosthesis as an effective option in the management of refractory ischemic priapism. C1 Brooke Army Med Ctr, Urol Serv, Ft Sam Houston, TX 78234 USA. RP Morey, AF (reprint author), Brooke Army Med Ctr, Urol Serv, Ft Sam Houston, TX 78234 USA. NR 3 TC 2 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2007 VL 172 IS 11 BP 1211 EP 1212 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 232FS UT WOS:000251004300016 ER PT J AU Babikian, S Emerson, L Wynn, GH AF Babikian, Sarkis Emerson, Lyndal Wynn, Gary H. TI Significance of cultural beliefs in presentation of psychiatric illness: A case report of selective mutism in a man from Nepal SO MILITARY MEDICINE LA English DT Article ID MILITARY; DISORDER; ANXIETY; SCHIZOPHRENIA; CATATONIA; FEATURES AB A 22-year-old active duty E1 Nepalese male who recently emigrated from Nepal suddenly exhibited strange behaviors and mutism during Advanced Individual Training. After receiving care from a hospital near his unit, he was transferred to Walter Reed Army Medical Center Inpatient Psychiatry for further evaluation and treatment. Although he was admitted with a diagnosis of psychosis not otherwise specified (NOS), after consideration of cultural factors and by ruling out concurrent thought disorder, a diagnosis of selective mutism was made. To our knowledge this is the first reported case of selective mutism in a soldier. This case serves as a reminder of the need for cultural awareness during psychological evaluation, diagnosis, and treatment of patients. C1 Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Babikian, S (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, 6900 Georgia Ave NW, Washington, DC 20307 USA. RI Wynn, Gary/B-3618-2011 NR 22 TC 1 Z9 1 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2007 VL 172 IS 11 BP 1213 EP 1216 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 232FS UT WOS:000251004300017 PM 18062400 ER PT J AU Myint, KSA Duripunt, P Mammen, MP Sirisopana, N Rodkvaintook, W Gibbons, RV AF Myint, Khin Saw Aye Duripunt, Pocharnan Mammen, Mammen P., Jr. Sirisopana, Narongrid Rodkvaintook, Wuttikon Gibbons, Robert V. TI Hepatitis e virus infection in Thai troops deployed with UN peacekeeping forces SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 55th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 11-16, 2006 CL Atlanta, GA SP Amer Soc Trop Med & Hyg ID OUTBREAK; EPIDEMIC; PAKISTAN; DISEASE AB The hepatitis E virus (HEV) is thought to be endemic throughout much of the world, particularly where sanitary infrastructure remains inadequate. HEV has been considered a military health threat and has been reported in several military environments. This study determined HEV seroconversion (defined by a 4-fold increase in antibody titers) occurring in Thai soldiers deployed to the HEV-endemic areas of East Timor, Afghanistan, and Iraq, as part of the U. N. multinational forces. With an average deployment of 6.4 months, the annualized seroconversion rates after deployments to East Timor, Afghanistan, Burundi, and Iraq were 1.9%, 4.6%, 4.6%, and 3.9%, respectively. C1 Armed Forces Res Inst Med Sci, US Army Med Component, Dept Virol, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, Div Res, Bangkok 10400, Thailand. RP Myint, KSA (reprint author), Armed Forces Res Inst Med Sci, US Army Med Component, Dept Virol, Bangkok 10400, Thailand. NR 17 TC 4 Z9 4 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2007 VL 172 IS 11 BP 1217 EP 1219 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 232FS UT WOS:000251004300018 PM 18062401 ER PT J AU Bellin, DA Devine, PJ AF Bellin, Daniel A. Devine, Patrick J. TI Constrictive pericarditis: A cause of exertion-induced Dyspnea in a soldier with a prior sternotomy SO MILITARY MEDICINE LA English DT Article ID RESTRICTIVE CARDIOMYOPATHY; DIAGNOSIS; SURGERY AB Diagnosing the underlying etiology of dyspnea on exertion in adults can be challenging, often requiring the clinician to distinguish cardiac or pulmonary pathological conditions from metabolic, neurological, or hematological conditions or from chest wall abnormalities. We report such a case involving a 29-year-old, male, active duty Army soldier. With a history of " median sternotomy, symptoms of right- and left-side heart failure, and examination findings suggesting elevated right atrial pressure, pericardial disease was pursued. Echocardiography and cardiac catheterization revealed constrictive physiological features, namely, elevation and near-equalization of right- and left-side pressures and ventricular interdependence, whereas computed tomography illustrated pericardial thickening, ultimately leading to the diagnosis of constrictive pericarditis. The patient was treated with a complete pericardiectomy, leading to symptom resolution and improved exercise capacity. This case report of a rare condition offers a concise etiological and physiological overview of constrictive pericarditis and demonstrates an effective multimodal diagnostic approach. The scientific evidence provided may assist general practitioners in making decisions to differentiate this clinical condition from similar cardiac or cardiopulmonary conditions. C1 Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Internal Med, Serv Cardiol, Washington, DC 20307 USA. RP Bellin, DA (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. NR 18 TC 1 Z9 1 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2007 VL 172 IS 11 BP 1220 EP 1223 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 232FS UT WOS:000251004300019 PM 18062402 ER PT J AU Barr, KR Dharmarajan, G Rhodes, OE Lance, RL Leberg, PL AF Barr, Kelly R. Dharmarajan, Guha Rhodes, Olin E., Jr. Lance, Richard L. Leberg, Paul L. TI Novel microsatellite loci for the study of the black-capped vireo (Vireo atricapillus) SO MOLECULAR ECOLOGY NOTES LA English DT Article DE black-capped vireos; endangered species; microsatellites; population genetics; songbirds; vireos AB We identified 14 novel polymorphic microsatellite loci in the black-capped vireo (Vireo atricapillus). We also attempted to amplify and genotype these loci in other Vireo species, including the white-eyed vireo (Vireo griseus), red-eyed vireo (Vireo olivaceus), and blueheaded vireo (Vireo solitarius). In 33 genotyped black-capped vireos from two locations, total alleles ranged from six to 20, with observed heterozygosity ranging from 0.58 to 0.91 and expected heterozygosity from 0.65 to 0.93. Two loci had detectable levels of null alleles. Many of the loci were able to be amplified in the related Vireo species. C1 Univ Louisiana, Dept Biol, Lafayette, LA 70504 USA. Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47907 USA. USA, Ctr Res Dev & Engn, Environm Lab, Vicksburg, MS 39180 USA. RP Barr, KR (reprint author), Univ Louisiana, Dept Biol, Lafayette, LA 70504 USA. EM krb0814@louisiana.edu RI Dharmarajan, Guha/E-7648-2012 NR 11 TC 6 Z9 6 U1 1 U2 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1471-8278 J9 MOL ECOL NOTES JI Mol. Ecol. Notes PD NOV PY 2007 VL 7 IS 6 BP 1067 EP 1069 DI 10.1111/j.1471-8286.2007.01779.x PG 3 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA 227HL UT WOS:000250647700039 ER PT J AU Romero, NA Kim, J Martin, RM AF Romero, Nichols A. Kim, Jeongnim Martin, Richard M. TI Electronic structures and superconductivity of endohedrally doped C-28 solids from first principles SO PHYSICAL REVIEW B LA English DT Article ID SMALLEST FULLERENE; GROUND-STATE; PHONON; CARBON; C-36; GAS; C28; STABILIZATION; HYPERDIAMOND; POTENTIALS AB We present ab initio calculations of the crystalline phases of C-28: hyperdiamond and hyperlonsdaleite, in their pristine and endohedrally doped forms. These are hard materials with strong covalent bonds between the C-28 molecules, and yet their electronic properties have remarkable similarities to the weakly bonded C28H4 molecular solids previously investigated [Phys. Rev. B 70, 140504(R) (2004)]. Our calculations show that they exhibit very narrow bands near the Fermi energy with an electron-phonon coupling that is well described by a molecular model and is larger than in C-60. Our study focuses on C-28 solids endohedrally doped with Zr, a group-IVB tetravalent atom. Solid Zr@C-28 is a small-gap insulator with Jahn-Teller distortions. Since the two structures considered are degenerate in energy, the actual material is expected to have disorder affecting the states at the Fermi energy and leading to a nonvanishing density of states. We conclude that the small density of states at the Fermi energy for Zr@C-28 will lead to a superconducting transition temperature T-c lower than that found in K3C60; however, our results suggest that a higher T-c may be obtained using group-IIIB trivalent atoms. C1 USA Res Lab, Aberdeen Proving Ground, MD 21005 USA. Univ Illinois, Mat Comp Ctr, Dept Phys, Mat Res Lab, Urbana, IL 61801 USA. Univ Illinois, Mat Comp Ctr, Dept Phys, Mat Res Lab,NCSA, Urbana, IL 61801 USA. RP Romero, NA (reprint author), USA Res Lab, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. NR 36 TC 9 Z9 9 U1 0 U2 6 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD NOV PY 2007 VL 76 IS 20 AR 205405 DI 10.1103/PhysRevB.76.205405 PG 6 WC Physics, Condensed Matter SC Physics GA 236TS UT WOS:000251326900078 ER PT J AU Childs, JD AF Childs, John D. TI On "a survey of therapeutic ultrasound..." Wong et al. Phys Ther. 2007;87 : 986-994 SO PHYSICAL THERAPY LA English DT Letter C1 USA, Baylor Doctoral Program Phys Therapy, San Antonio, TX USA. RP Childs, JD (reprint author), USA, Baylor Doctoral Program Phys Therapy, San Antonio, TX USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD NOV PY 2007 VL 87 IS 11 BP 1558 EP 1558 DI 10.2522/ptj.2007.87.11.1558.1 PG 1 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 229LA UT WOS:000250803300016 PM 17974575 ER PT J AU Naumann, JC Young, DR Anderson, JE AF Naumann, Julie C. Young, Donald R. Anderson, John E. TI Linking leaf chlorophyll fluorescence properties to physiological responses for detection of salt and drought stress in coastal plant species SO PHYSIOLOGIA PLANTARUM LA English DT Article ID XANTHOPHYLL CYCLE; BARRIER-ISLAND; WATER-STRESS; PHRAGMITES-AUSTRALIS; STOMATAL CONDUCTANCE; GAS-EXCHANGE; PHOTOSYNTHETIC CHARACTERISTICS; OSMOTIC ADJUSTMENT; ENERGY-DISSIPATION; A FLUORESCENCE AB Effects of salinity and drought on physiology and chlorophyll fluorescence were used to evaluate stress in two coastal plants, Myrica cerifera (L.) and Phragmites australis (Cav.) Trin. ex Steud. Drought and salinity stress were induced and measurements of stomatal conductance, photosynthesis, xylem pressure potential (psi) and fluorescence were conducted following treatment. The onset of stress began at 2 g l(-1) for M. cerifera, and 5 g l(-1) for P. australis, as seen by significant decreases in physiological measurements. Despite the physiological effects of salinity, there was no significant difference in dark-adapted fluorescence (F-v/F-m, where F-m is the maximal fluorescence in dark-adapted leaves) for either species at any salinity level. Significant decreases in the light-adapted measurement Delta F/F'(m) (F'(m) is maximal fluorescence in light-adapted leaves) occurred at 10 g l(-1) in M. cerifera and P. australis, days before visible stress was evident. The quantum yield of xanthophyll-regulated thermal energy dissipation (Phi(NPQ), where NPQ is non-photochemical quenching of chlorophyll fluorescence) increased with decreasing Delta F/F'(m). Drought studies showed similar results, with significant decreases in physiological measurements occurring by day 2 in M. cerifera and day 4 in P. australis. Differences in Delta F/F'(m) were seen by day 5 for both species, whereas F-v/F-m showed no indication of stress, despite apparent visible signs. Xanthophyll-cycle-dependent energy dissipation may be the underlying mechanism in protecting photosystem II from excess energy in salinity- and drought-treated plants. C1 Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. US Army ERDC, Fluorescence Spectroscopy Lab, Alexandria, VA 22315 USA. RP Young, DR (reprint author), Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. EM dryoung@vcu.edu NR 43 TC 54 Z9 61 U1 5 U2 23 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0031-9317 J9 PHYSIOL PLANTARUM JI Physiol. Plant. PD NOV PY 2007 VL 131 IS 3 BP 422 EP 433 DI 10.1111/j.1399-3054.2007.00973.x PG 12 WC Plant Sciences SC Plant Sciences GA 215RQ UT WOS:000249827100007 PM 18251881 ER PT J AU Williams, S Wynn, G Cozza, K Sandson, NB AF Williams, Scott Wynn, Gary Cozza, Kelly Sandson, Neil B. TI Cardiovascular medications SO PSYCHOSOMATICS LA English DT Article ID CONVERTING ENZYME-INHIBITORS; DRUG-DRUG INTERACTIONS; HUMAN LIVER-MICROSOMES; CARBAMAZEPINE INTERACTION; MYOCARDIAL-INFARCTION; LITHIUM CLEARANCE; CARDIAC DRUG; WARFARIN; PHARMACOKINETICS; METOPROLOL C1 Walter Reed Army Med Ctr, Dept Psychiat, Inpatient Psychiat Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA. RP Williams, S (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, Inpatient Psychiat Serv, Washington, DC 20307 USA. RI Wynn, Gary/B-3618-2011 NR 79 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD NOV-DEC PY 2007 VL 48 IS 6 BP 537 EP 547 DI 10.1176/appi.psy.48.6.537 PG 11 WC Psychiatry; Psychology SC Psychiatry; Psychology GA 228OK UT WOS:000250739100014 PM 18071104 ER PT J AU Chung, EM Smirniotopoulos, AG Specht, CS Schroeder, JW Cube, R AF Chung, Ellen M. Smirniotopoulos, Ames G. Specht, Charles S. Schroeder, Jason W. Cube, Regino TI From the archives of the AFIP - Pediatric orbit tumors and tumorlike lesions: Nonosseous lesions of the extraocular orbit SO RADIOGRAPHICS LA English DT Article ID INTRACRANIAL VASCULAR ANOMALIES; INFANTILE MYOFIBROMATOSIS; INTERGROUP RHABDOMYOSARCOMA; CAPILLARY HEMANGIOMA; SIMULATING LESIONS; AGE-GROUP; MALFORMATIONS; MR; FIBROMATOSIS; CHILDREN AB The histologic spectrum of nonosseous tumors and tumorlike lesions of the extraocular orbit in children differs from that in adults, and the appearance of these lesions at imaging reflects their pathologic features. Rhabdomyosarcoma is the most common extraocular orbital tumor in children. This neoplasm usually manifests in young children, grows quite rapidly, and is fairly vascular. Vasculogenic lesions are common orbital lesions in newborns and young infants. The most prevalent of these are infantile hemangioma, a true neoplasm, and venous-lymphatic malformation, a developmental anomaly. Hemangioma is quite vascular, has a predictable course of proliferation followed by slow involution, and is distinguished on magnetic resonance images by the finding of flow voids within the mass and at its periphery. Venous-lymphatic malformation in the orbit is an anomaly of venous and lymphatic development that is characterized by unenhancing, cystic lymphatic and enhancing, solid venous components. Intralesional hemorrhage is common and frequently produces distinctive fluid-fluid levels within the cystic portions. Unlike hemangiomas, venous-lymphatic malformations grow with the patient and never involute spontaneously. Infantile fibromatosis is one of the fibromatoses and affects newborns and young infants. The tumor is nodular and composed of a zonal architecture, with frequent hemorrhage or necrosis in the central portion, characteristics that confer a target appearance at imaging. These lesions usually stop growing or spontaneously regress. All of these extraocular masses typically manifest with proptosis, and imaging differentiation is desirable because the treatments and prognoses vary greatly. C1 Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. Armed Forces Inst Pathol, Dept Neuropathol, Ophthalm Pathol Sect, Washington, DC 20306 USA. Uniformed Univ Hlth Sci, F Edward Hebert Sch Med, Dept Radiol & Radiol Sci, Bethesda, MD USA. Natl Naval Med Ctr, Natl Capitol Radiol Consortium, Bethesda, MD USA. Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Chung, EM (reprint author), Armed Forces Inst Pathol, Dept Radiol Pathol, 6825 16th St NW, Washington, DC 20306 USA. EM chunge@afip.osd.mil NR 57 TC 25 Z9 30 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD NOV-DEC PY 2007 VL 27 IS 6 BP 1777 EP 1799 DI 10.1148/rg.276065138 PG 23 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 230QO UT WOS:000250891200019 PM 18025517 ER PT J AU Cohen, SP Bajwa, ZH Kraemer, JJ Dragovich, A Williams, KA Stream, J Sireci, A McKnight, G Hurley, RW AF Cohen, Steven P. Bajwa, Zahid H. Kraemer, Jan J. Dragovich, Anthony Williams, Kayode A. Stream, Joshua Sireci, Anthony McKnight, Giselle Hurley, Robert W. TI Factors predicting success and failure for cervical facet radiofrequency denervation: A multi-center analysis SO REGIONAL ANESTHESIA AND PAIN MEDICINE LA English DT Article DE cervical facet joint; medial branch block; neck pain; predictive value; Radiofrequency; Zy-gapophyseal joint ID LOW-BACK-PAIN; ZYGAPOPHYSEAL-JOINT PAIN; CHRONIC NECK PAIN; DOUBLE-BLIND; CERVICOGENIC HEADACHE; CLINICAL-EVALUATION; PREVALENCE; NEUROTOMY; WHIPLASH; BLOCKS AB Background and Objectives: The concept of radiofrequency denervation has recently conic under question in light of several studies showing minimal to no benefit. One possibility proposed for these negative outcomes is poor selection criteria. Unlike virtually all other spine interventions, the factors associated with success and failure for cervical facet denervation have yet to be determined. The purpose of this study is to determine which demographic, clinical and treatment factors are associated with cervical facet radiofrequency denervation outcomes. Methods: Data were garnered from 3 academic medical centers on 92 patients with chronic neck pain who underwent radiofrequency denervation after a positive response to diagnostic local anesthetic blocks. Success was defined as at least 50% pain relief lasting at least 6 months. Variables evaluated for their association with outcome included age, sex, duration of pain, opioid use, pain referral pattern, paraspinal tenderness, pain exacerbated by extension/rotation, magnetic resonance image abnormalities, diabetes, smoking, scoliosis, obesity, prior surgery, and levels treated. Results: The only clinical variable associated with success was paraspinal tenderness. Factors associated with treatment failure included radiation to the head, opioid use, and pain exacerbated by neck extension and/or rotation. Conclusions: Selecting patients based on key clinical variables may increase the chance of treatment success for cervical facet radiofrequency denervation. C1 Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Anesthesiol & Crit Care,Pain Management Div, Boston, MA USA. Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA. Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Pain Management Div, Baltimore, MD 21205 USA. RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu NR 57 TC 45 Z9 46 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1098-7339 J9 REGION ANESTH PAIN M JI Region. Anesth. Pain Med. PD NOV-DEC PY 2007 VL 32 IS 6 BP 495 EP 503 DI 10.1016/i.rapm.2007.05.009 PG 9 WC Anesthesiology SC Anesthesiology GA 238DZ UT WOS:000251428800007 PM 18035295 ER PT J AU Abbott, KC Oliver, DK Hurst, FP Das, NP Gao, SW Perkins, RM AF Abbott, Kevin C. Oliver, David K. Hurst, Frank P. Das, Neal P. Gao, Sam W. Perkins, Robert M. TI Body mass index and peritoneal dialysis: "Exceptions to the exception" in reverse epidemiology? SO SEMINARS IN DIALYSIS LA English DT Article ID STAGE RENAL-DISEASE; SHORT-TERM SURVIVAL; UNITED-STATES; PATIENT CHARACTERISTICS; ESRD PATIENTS; MORTALITY; HEMODIALYSIS; OBESITY; ASSOCIATION; CREATININE AB Until recently, it was not apparent whether apparent paradoxical associations of body mass index (BMI), lipids, and blood pressure with survival observed in hemodialysis (HD) patients, which contradict observations from the general population, also applied to peritoneal dialysis (PD) patients. Studies of survival in PD patients must account for differences in adjusted survival relative to HD patients, namely, early equivalent to superior survival, but after about 1-2 years, inferior survival. Several recent observational studies have analyzed the association between BMI and survival in PD patients from different perspectives and using different patient populations. In general, these studies found that any survival advantage associated with obesity is significantly less likely in PD than HD patients. Among PD patients, those who are obese can be said to have equivalent survival to PD patients with normal BMI. Studies of lipids and blood pressure in PD patients also yield conflicting associations with survival. Obese patients, especially if diabetic, may have increased risk of death after starting on PD compared to HD, although firm conclusions are premature given the limitations of current evidence. At present, the levels of lipids and blood pressure which are best associated with survival in PD patients are not well-defined. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM kevin.abbott@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 28 TC 13 Z9 13 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0894-0959 J9 SEMIN DIALYSIS JI Semin. Dial. PD NOV-DEC PY 2007 VL 20 IS 6 BP 561 EP 565 DI 10.1111/j.1525-139X.2007.00347.x PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 228WV UT WOS:000250764200015 PM 17991205 ER PT J AU Walick, KS Kragh, JE Ward, JA Crawford, JJ AF Walick, Kristina S. Kragh, John E., Jr. Ward, John A. Crawford, John J. TI Changes in Intraocular pressure due to surgical positioning - Studying potential risk for postoperative vision loss SO SPINE LA English DT Article DE intraocular pressure; prone Trendelenburg; postoperative vision loss ID ISCHEMIC OPTIC NEUROPATHY; LUMBAR SPINE SURGERY; RETINAL ARTERY-OCCLUSION; HEAD-DOWN TILT; VISUAL-LOSS; UNILATERAL BLINDNESS; COMPLICATION; HYPOTENSION; CIRCULATION; ANESTHESIA AB Study Design. Parallel group design. Objective. Compare the intraocular pressure responses in the prone flat versus prone Trendelenburg's position. Summary of Background Data. Postoperative vision loss (PVL) complicates approximately 0.05% of spine surgeries. Prone positioning is considered a risk factor because it increases intraocular pressure, which may decrease perfusion pressure to the optic nerve (perfusion pressure=mean arterial pressure - intraocular pressure [ IOP]). The prone Trendelenburg's position is often used during spine surgery; however, its effect on optic nerve perfusion is unknown. The purpose of this study is to compare the IOP responses in the prone flat versus prone Trendelenburg's positions to determine if prone Trendelenburg's position also risks PVL. Methods. Twenty subjects randomized into 2 groups. Group 1 lay in the prone flat position (0 degrees). Group 2 lay in the prone Trendelenburg's position (-7 degrees). IOPs were measured with a hand-held applanation tonometer while seated, 1 minute after assuming the group's position (Time 0), and at 10-minute intervals for 60 minutes. Results. The differences in mean IOPs with respect to positions and time were significant (P=0.0001, P=0.000). There was a significant difference between sitting and all other times for both groups. In Group 1, there was a significant difference in IOP between Time 0 and all other times prone flat (P < 0.05). In Group 2, there was a significant difference in IOP between Time 0 all other times prone Trendelenburg (P < 0.05). Conclusion. IOP increases in the prone Trendelenburg's position, and when combined with other factors, may be a risk factor for PVL. The pathophysiology is discussed and suggestions for clinicians are made. C1 Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Dept Clin Invest, Ft Sam Houston, TX USA. RP Walick, KS (reprint author), 134 Lamont Ave, San Antonio, TX 78209 USA. EM Kristina.walick@amedd.army.mil NR 51 TC 19 Z9 21 U1 0 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD NOV 1 PY 2007 VL 32 IS 23 BP 2591 EP 2595 PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 229UV UT WOS:000250832300012 PM 17978659 ER PT J AU Smith, R Sharif, N AF Smith, Roger Sharif, Nawaz TI Understanding and acquiring technology assets for global competition SO TECHNOVATION LA English DT Article DE technology assets; global competition; capabilities; competencies; technology strategy ID CAPABILITIES AB Technology assets play a crucial role in enabling the competitiveness of companies in most industries. Several authors have proposed models that illustrate the role of these assets during different phases of a company's development. In this paper, we develop a model that shows the important role of technology, human expertise, organizational structure, and information assets in positioning a company for global competition. This model integrates earlier work by Christensen and Overdorf [2000. Meeting the challenge of disruptive change. Harvard Business Review], Leonard-Barton [1992. Core capabilities and core rigidities: A Paradox in new product development. Strategic Management Journal, 13, 111-126], Sharif [1995. The Evolution of technology management studies: Technoeconomics to technometrics. Technology management: Strategies and applications for practitioners, 2(3), 113-148], and Subramaniam, Youndt, [2005. The Influence of intellectual capital on the types of innovative capabilities. Academy of Management Journal, 48(3), 450-463] to show the similarities that hide behind the unique terminology presented in these earlier works. In this paper, we attempt to clearly identify the types of technology assets that a company must acquire and apply in order to be successful in the marketplace. Numerous authors have talked about the importance of managing technologies and "weaving streams of technology" without explicitly defining these technologies. We suggest that managers must consider much more than just traditional R&D and the acquisition of new equipment that represent "hard technology". Rather, a manager must leverage the power of humanware, technoware, inforware, and orgaware. Further, we suggest that each of these plays a dominant role during a different phase of a company's lifecycle. As an asset moves from a dominant position to a supporting position, it moves from a differentiating competency, to an operational capability. (C) 2007 Elsevier Ltd. All rights reserved. C1 USA, PEO Simulat Training & Instrumentat, Orlando, FL 32826 USA. Univ Maryland, Univ Coll, Adelphi, MD USA. RP Smith, R (reprint author), USA, PEO Simulat Training & Instrumentat, 12350 Res Pkwy, Orlando, FL 32826 USA. EM roger.smith@peostri.army.mil; nsliarif@umuc.edu NR 19 TC 16 Z9 17 U1 2 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-4972 J9 TECHNOVATION JI Technovation PD NOV PY 2007 VL 27 IS 11 BP 643 EP 649 DI 10.1016/j.technovation.2007.04.001 PG 7 WC Engineering, Industrial; Management; Operations Research & Management Science SC Engineering; Business & Economics; Operations Research & Management Science GA 230NQ UT WOS:000250883600001 ER PT J AU Dabisch, PA Horsmon, MS Muse, WT Mioduszewski, RJ Thomson, S AF Dabisch, Paul A. Horsmon, Michael S. Muse, William T. Mioduszewski, Robert J. Thomson, Sandra TI Muscarinic receptor dysfunction induced by exposure to low levels of soman vapor SO TOXICOLOGICAL SCIENCES LA English DT Article DE miosis; soman; organophosphates; muscarinic receptors; pupillary light reflex ID TERM DESENSITIZATION; PUPILLARY DILATION; LIGHT REFLEX; ACETYLCHOLINE; RATS; IRIS; DIAGNOSIS; RELEASE; INVIVO; KINASE AB In the eye, it has been previously reported that exposure to a cholinesterase inhibitor results in a reduced miotic response following prolonged exposure and a decreased miotic response to the cholinergic agonists. However, no studies exist that characterize the effect of a single low-level vapor exposure to a nerve agent on parasympathetic function in the eye or determine the threshold dose for such an effect. The present study investigated the hypotheses that a single low-level exposure to soman vapor would result in dysfunction of the parasympathetic pathway mediating the pupillary light reflex resulting from a loss of muscarinic receptor function on the pupillary sphincter muscle. Adult male rats were exposed to soman vapor in a whole-body dynamic airflow exposure chamber. Rats exposed to low levels of soman vapor dose-dependently developed miosis (threshold dose between 4.1 and 6.1 mg-min/m(3)). Pupil size returned to preexposure levels within 48 h due to desensitization of pupillary muscarinic receptors, as assessed by the pupillary response to the muscarinic agonist oxotremorine. An attenuated pupillary light reflex was also present in miotic animals (threshold dose near 6.1 mg-min/m(3)). While pupil size recovers within 48 h, other measures of pupillary function, including the light reflex, acetylcholinesterase activity, and muscarinic receptor responsiveness, did not return to normal for up to 10 days postexposure. Recovery of the light reflex coincided with the recovery of pupillary muscarinic receptor function, suggesting that the attenuation of the light reflex was due to receptor desensitization. C1 USA, Edgewood Chem Biol Ctr, Operat Toxicol Team, ATTN AMSRD ECB RT TT, Aberdeen Proving Ground, MD 21010 USA. RP Dabisch, PA (reprint author), USA, Edgewood Chem Biol Ctr, Operat Toxicol Team, ATTN AMSRD ECB RT TT, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM paul.a.dabisch@us.army.mil NR 32 TC 10 Z9 10 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 J9 TOXICOL SCI JI Toxicol. Sci. PD NOV PY 2007 VL 100 IS 1 BP 281 EP 289 DI 10.1093/toxsci/kfm213 PG 9 WC Toxicology SC Toxicology GA 227VT UT WOS:000250686600030 PM 17693423 ER PT J AU Hughes, JD Macdonald, VW Hess, JR AF Hughes, J. D. Macdonald, V. W. Hess, J. R. TI Warm storage of whole blood for 72 hours SO TRANSFUSION LA English DT Article ID PLATELET-RICH PLASMA; RED-CELL STORAGE; PRESERVATION; COAGULATION; EXERCISE; 2,3-DIPHOSPHOGLYCERATE; 25-DEGREES-C; TRANSFUSION; ACTIVATION AB Background: In field emergency medicine, fresh whole-blood units are stored at room temperature up to 24 hours or occasionally longer. Few data exist on the integrity and in vitro functional properties of whole blood stored warm beyond 24 hours. Study Design and Methods: Ten citrate phosphate dextrose solution whole-blood units were collected and divided into two equal volumes. One-half of each unit was stored at 19 degrees C and the other half was stored at 25 degrees C, encompassing the accepted range for room temperature storage. At 6, 24, 48, and 72 hours, aliquots were collected from each unit and whole blood analyzed for cell counts, gases, and clotting function with thromboelastography, red cells for intracellular analytes, platelet (PLT)-rich plasma for aggregometry, and the supernatant for hemoglobin, potassium, glucose, lactate, and plasma clotting studies. Results: Whole-blood units stored at room temperature maintained cellular counts and coagulation activity for up to 72 hours. Units stored at 19 degrees C demonstrated greater RBC adenosine triphosphate and 2,3-diphosphoglycerate (DPG) content and stronger responses in PLT aggregation studies when compared with 25 degrees C storage. No significant hemolysis was observed, and no bacterial growth was detected. Conclusion: Storage of whole blood at room temperature for 72 hours leads to marked reductions in pH and DPG, but the observed reduction in PLT function and plasma coagulation factor activity was surprisingly modest compared to literature values. These findings should prompt additional investigation, given their potential importance for whole blood processing and field-expedient transfusion. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Walter Reed Army Inst Res, Blood Res Detachment, Silver Spring, MD USA. Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA. RP Hess, JR (reprint author), Univ Maryland, Med Ctr, 22 S Green St, Baltimore, MD 21201 USA. EM jhess@umm.edu NR 30 TC 39 Z9 40 U1 2 U2 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD NOV PY 2007 VL 47 IS 11 BP 2050 EP 2056 DI 10.1111/j.1537-2995.2007.01429.x PG 7 WC Hematology SC Hematology GA 223IS UT WOS:000250364100015 PM 17958534 ER PT J AU Arnaud, F Fasipe, D Philbin, N Rice, J Flournoy, WS Ahlers, S McCarron, R Freilich, D AF Arnaud, Francoise Fasipe, Daniel Philbin, Nora Rice, Jennifer Flournoy, W. Shannon Ahlers, Stephen McCarron, Richard Freilich, Daniel TI Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care SO TRANSFUSION LA English DT Article ID BOVINE POLYMERIZED HEMOGLOBIN; MULTIPLE ORGAN FAILURE; SHOCK SWINE MODEL; LIVER-INJURY; BLOOD-TRANSFUSION; CELL TRANSFUSION; TRAUMA PATIENTS; HETASTARCH HEX; HBOC-201; COAGULOPATHY AB Background: The hemoglobin-based oxygen carrier (HBOC-201) resuscitation fluid improves outcome in hemorrhagic shock swine models with minimal coagulopathy. Herein, coagulation parameters were evaluated after resuscitation with HBOC-201 after severe bleeding and prolonged delay to definitive care. Study Design and Methods: After 55 percent estimated blood volume-controlled hemorrhage by catheter withdrawal, swine (n = 48) were resuscitated with HBOC-201 or Hextend (HEX) infused in four doses over 4 hours or not resuscitated (NON). Animals were randomly assigned in two cohorts of 4- or 24-hour simulated delay to hospital arrival (access to blood and saline infusions up to 72 hr). In vitro hematologic monitoring was assessed with complete blood count, hemostasis (thromboelastography [TEG], in vitro bleeding time [PFA]), and coagulation (prothrombin time [PT], thrombin-antithrombin, fibrinogen) indices. Results: Within groups, survival was unaffected by extending delay from 4 to 24 hours. Combined survival was similar for HBOC-201 and HEX but lower for NON animals (93.5, 81.5, and 25 percent, respectively; p < 0.01). Blood transfusion requirements were lower with HBOC-201 than HEX. Elevated TEG and PFA parameters in resuscitated animals reflected fluid and blood transfusion regimens. TEG reaction time and PFA were transiently higher with HBOC-201 than with HEX during the early hospital phase. PT was increased in HEX animals. Conclusion: In this severe model, survival was equivalent with HBOC-201 and HEX resuscitation. HBOC-201 or HEX allowed delayed hospital arrival to 24 hours without worsening coagulation parameters, but dilutional mild coagulopathy in the hospital phase persisted with HBOC-201 due to blood transfusion avoidance. Low hematocrit suggests that blood administration after HBOC-201 resuscitation could be beneficial to replete blood cellular mass. C1 Naval Med Res Ctr, Trauma & Resuscitativ Med Dept, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Vet Med, Silver Spring, MD USA. RP Arnaud, F (reprint author), Naval Med Res Ctr, Trauma & Resuscitativ Med Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM arnaudf@nmrc.navy.mil NR 39 TC 7 Z9 7 U1 1 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD NOV PY 2007 VL 47 IS 11 BP 2098 EP 2109 DI 10.1111/j.1537-2995.2007.01435.x PG 12 WC Hematology SC Hematology GA 223IS UT WOS:000250364100021 PM 17958540 ER PT J AU Cygan, RT Stevens, CT Puls, RW Yabusaki, SB Wauchope, RD McGrath, CJ Curtis, GP Siegel, MD Veblen, LA Turner, DR AF Cygan, Randall T. Stevens, Caroline T. Puls, Robert W. Yabusaki, Steven B. Wauchope, Robert D. McGrath, Christian J. Curtis, Gary P. Siegel, Malcolm D. Veblen, Linda A. Turner, David R. TI Research activities at US government agencies in subsurface reactive transport modeling SO VADOSE ZONE JOURNAL LA English DT Review ID URANYL(VI) ADSORPTION EQUILIBRIA; MOLECULAR-DYNAMICS SIMULATION; CATION-EXCHANGE MODEL; SAVANNA RIVER SITE; OIL SPILL SITE; HANFORD SITE; CRUDE-OIL; HYDROCARBON BIODEGRADATION; CONTAMINATED GROUNDWATER; GEOCHEMICAL TRANSPORT AB The fate of contaminants in the environment is controlled by both chemical reactions and transport phenomena in the subsurface. Our ability to understand the significance of these processes over time requires an accurate conceptual model that incorporates the various mechanisms of coupled chemical and physical processes. Adsorption, desorption, ion exchange, precipitation, dissolution, growth, solid solution, redox, microbial activity, and other processes are often incorporated into reactive transport models for the prediction of contaminant fate and transport. U. S. federal agencies use such models to evaluate contaminant transport and provide guidance to decision makers and regulators for treatment issues. We provide summaries of selected research projects and programs to demonstrate the level of activity in various applications and to present examples of recent advances in subsurface reactive transport modeling. C1 [Cygan, Randall T.; Siegel, Malcolm D.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Puls, Robert W.] US EPA, Athens, GA 30605 USA. [Puls, Robert W.] US EPA, Ada, OK 74820 USA. [Yabusaki, Steven B.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Wauchope, Robert D.] USDA, Tifton, GA 31793 USA. [McGrath, Christian J.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Curtis, Gary P.] US Geol Survey, Menlo Pk, CA 94025 USA. [Veblen, Linda A.] US Nucl Regulatory Commiss, Washington, DC 20555 USA. [Turner, David R.] SW Res Inst, Ctr Nucl Waste Regulatory Anal, San Antonio, TX 78228 USA. RP Cygan, RT (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. EM rtcygan@sandia.gov NR 121 TC 6 Z9 6 U1 1 U2 8 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA SN 1539-1663 J9 VADOSE ZONE J JI Vadose Zone J. PD NOV PY 2007 VL 6 IS 4 BP 805 EP 822 DI 10.2136/vzj2006.0091 PG 18 WC Environmental Sciences; Soil Science; Water Resources SC Environmental Sciences & Ecology; Agriculture; Water Resources GA 254OO UT WOS:000252596100013 ER PT J AU Batchinsky, AI Cooke, WH Kuusela, TA Jordan, BS Wang, JJ Cancio, LC AF Batchinsky, Andriy I. Cooke, William H. Kuusela, Tom A. Jordan, Bryan S. Wang, Jing Jing Cancio, Leopoldo C. TI Sympathetic nerve activity and heart rate variability during severe hemorrhagic shock in sheep SO AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL LA English DT Article DE autonomic nervous system; renal sympathetic nerve activity; hemorrhagic shock; heart rate variability; spectrum analysis; non-linear analysis; complexity; entropy ID BODY NEGATIVE-PRESSURE; POWER SPECTRAL-ANALYSIS; CRITICAL-APPRAISAL; ARTERIAL-PRESSURE; HYPOVOLEMIC SHOCK; CONSCIOUS DOGS; BLOOD-PRESSURE; RATE RESPONSE; COMPLEXITY; ENTROPY AB Introduction: In this study we explored direct and indirect measures of autonomic nervous system function, as well as changes in cardiovascular complexity, during hemorrhagic shock (HS). Methods: HS was induced in anesthetized sheep (n = 8) by removing 40 ml/kg of blood in four 10 ml/kg steps over 40 min. Resuscitation was perfortried with lactated Ringer's and re-infusion of shed blood. Renal sympathetic nerve activity (RSNA) was measured by microneurography. Spectral analysis of heart rate variability (HRV) employed fast-Fourier transformation of the R-to-R interval (RRI) of the EKG. This generated the normalized high-frequency (HFnu) and low-frequency (LFnu) powers of the RRI, and their ratio (LFna/HFnu, a proposed index of sympatho-vagal balance). Additionally, non-linear methods were applied: RRI complexity was measured by approximate (ApEn) and sample (SampEn) entropy methods; RRI fractal dimension was measured by curve lengths (FDCL). Plasma catecholamines were determined by HPLC. Results: The model caused profound HS; 2/8 animals survived till the end of resuscitation. RSNA increased in 7/8 sheep and, as HS progressed, multiple burst complexes were identified followed by sympathetic withdrawal. Concomitant decreases in HFnu and increases in LFnu/HFnu occurred after 20 ml/kg blood loss. ApEn and FDCL decreased after withdrawal of 40 ml/kg of blood. Catecholamine concentrations increased throughout HS. LFnu/HFnu and RSNA were not linearly correlated. Conclusions: HS led to an increase in RSNA with subsequent withdrawal. LFnu/HFnu increased during HS in association with vagal withdrawal and loss of RRI complexity. RRI complexity may in part reflect vagal modulation of the heart rate. Changes in directly measured tonic sympathetic traffic do not correlate with non-invasive measures of autonomic modulation of the heart. (c) 2007 Elsevier B.V. All rights reserved. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas, Dept Kinesiol & Hlth Educ, Lab Appl Autonom Neurophysiol, San Antonio, TX 78249 USA. Univ Turku, Dept Phys, SF-20500 Turku, Finland. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM andriy.batchinsky@amed.army.mil NR 46 TC 21 Z9 21 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1566-0702 J9 AUTON NEUROSCI-BASIC JI Auton. Neurosci-Basic Clin. PD OCT 30 PY 2007 VL 136 IS 1-2 BP 43 EP 51 DI 10.1016/j.autneu.2007.03.004 PG 9 WC Neurosciences SC Neurosciences & Neurology GA 222AX UT WOS:000250269600004 PM 17482525 ER PT J AU Eckart, RE Hruczkowski, TW Tedrow, UB Koplan, BA Epstein, LM Stevenson, WG AF Eckart, Robert E. Hruczkowski, Tomasz W. Tedrow, Usha B. Koplan, Bruce A. Epstein, Laurence M. Stevenson, William G. TI Sustained ventricular tachycardia associated with corrective valve surgery SO CIRCULATION LA English DT Article DE ablation; arrhythmia; catheter ablation; valves; tachycardia, ventricular ID CATHETER ABLATION; REENTRANT TACHYCARDIA; CARDIAC-SURGERY; HEART-DISEASE; IDENTIFICATION; ISTHMUS; PATIENT; TERM AB Background - The causes of sustained monomorphic ventricular tachycardia (VT) after cardiac valve surgeries have not been studied extensively, although bundle- branch reentry has been reported. Methods and Results - Records of 496 patients referred for electrophysiology study and catheter ablation of recurrent VT were reviewed. Twenty patients (4%) had VT after aortic or mitral valve surgery in the absence of known myocardial infarction. The median age was 53 years, and the median ejection fraction was 45%. In 4 patients, VT occurred early after surgery, and electrophysiology study was performed 3 to 10 days later. In the remaining patients, electrophysiology study was performed a median of 12 years (interquartile range 5 to 15 years) after surgery. Sustained VT was inducible in 17 patients. VT was attributed to scar-related reentry in 14 patients (70%) and to bundle-branch reentry in 2 (10%). Multiple VTs were present in 9 of 14 patients with scar- related reentry. A total of 42 induced VTs were targeted for ablation. Of the 14 patients with scar- related reentry, 9 (64%) had periannular scar, and 10 (71%) had an identifiable endocardial circuit isthmus. Ablation abolished 41 (98%) of the 42 targeted VTs. At a median follow-up of 2.1 years, 3 deaths occurred 8 to 14 months after ablation. One patient with incessant VT early after valve surgery suffered a stroke with residual hemianopsia. Of the 20 patients, 3 required repeat ablation after recurrence, and 2 of these who were not inducible during electrophysiology study had clinical recurrence that necessitated ablation. Conclusions - Sustained VT after valve surgery appears to be bimodal in presentation, occurring either early after surgery or years later. In this referral population, reentry in a region of scar is more common than bundle- branch reentry. Catheter ablation can be successful. C1 USA, Arrhythmia Serv Cardiol, Brooke Army Med Ctr, MCHE,MDC, San Antonio, TX 78234 USA. Brigham & Womens Hosp, Boston, MA 02115 USA. Harvard Univ, Sch Med, Boston, MA USA. RP Eckart, RE (reprint author), USA, Arrhythmia Serv Cardiol, Brooke Army Med Ctr, MCHE,MDC, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM robert.eckart@us.army.mil NR 17 TC 30 Z9 30 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 30 PY 2007 VL 116 IS 18 BP 2005 EP 2011 DI 10.1161/CIRCULATIONAHA.107.703157 PG 7 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 225KY UT WOS:000250518000003 PM 17923574 ER PT J AU Mosurkal, R Samuelson, LA Parmar, VS Kumar, J Watterson, AC AF Mosurkal, Ravi Samuelson, Lynne A. Parmar, Virinder S. Kumar, Jayant Watterson, Arthur C. TI Biocatalytic synthesis of organosiloxane copolyimide SO MACROMOLECULES LA English DT Article C1 USA, Natick Soldier RDEC, Natick, MA 01760 USA. Univ Delhi, Dept Chem, Delhi 10007, India. Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. Univ Massachusetts, Inst Nanosci & Engn Technol, Lowell, MA 01854 USA. RP Watterson, AC (reprint author), USA, Natick Soldier RDEC, Natick, MA 01760 USA. EM Lynne.Samuelson@us.army.mil; Arthur_Watterson@uml.edu RI MOSURKAL, RAVI/P-6981-2015 NR 10 TC 16 Z9 16 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD OCT 30 PY 2007 VL 40 IS 22 BP 7742 EP 7744 DI 10.1021/ma0714924 PG 3 WC Polymer Science SC Polymer Science GA 223NQ UT WOS:000250377900004 ER PT J AU Kholod, Y Okovytyy, S Kuramshina, G Qasim, M Gorb, L Leszczynski, J AF Kholod, Yana Okovytyy, Sergiy Kuramshina, Gulnara Qasim, Mohammad Gorb, Leonid Leszczynski, Jerzy TI An analysis of stable forms of CL-20: A DFT study of conformational transitions, infrared and Raman spectra SO JOURNAL OF MOLECULAR STRUCTURE LA English DT Article DE CL-20 conformations; infrared and Raman spectra; density functional theory ID THERMAL-STABILITY; HEXANITROHEXAAZAISOWURTZITANE; POLYMORPHS AB The most stable forms of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) were analyzed at the B3LYP/6-31 G+(d,p) level of theory. The mechanism of conformational transformations was clarified. The activation energies of those transitions were found to be quite low and lie in the range 1.2-4.0kcalmol(-1). IR and Raman spectra of the studied CL-20 forms were simulated. The predicted vibrational modes were used for comparison with the experimental values. The unique peaks for each of the conformers in IR and Raman spectra were found. These peaks can be used as the "signatures" of the studied conformers and for identification of different polymorphs of CL-20 in mixtures. (c) 2007 Elsevier B.V. All rights reserved. C1 Jackson State Univ, Computat Ctr Mol Struct Interactions, Jackson, MS 39217 USA. Dnepropetrovsk Nat Univ, UA-49050 Dnepropetrovsk, Ukraine. Moscow MV Lomonosov State Univ, Moscow 119899, Russia. US Army ERDC, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Computat Ctr Mol Struct Interactions, Jackson, MS 39217 USA. EM jerzy@ccmsi.us RI Okovytyy, Sergiy/F-9838-2010; Kuramshina, Gulnara/G-8974-2011 OI Okovytyy, Sergiy/0000-0003-4367-1309; Kuramshina, Gulnara/0000-0002-4044-471X NR 22 TC 37 Z9 39 U1 6 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2860 J9 J MOL STRUCT JI J. Mol. Struct. PD OCT 29 PY 2007 VL 843 IS 1-3 BP 14 EP 25 DI 10.1016/j.molstruc.2006.12.031 PG 12 WC Chemistry, Physical SC Chemistry GA 222EL UT WOS:000250278800002 ER PT J AU Duby, JM DiFurio, MJ AF Duby, Jeanne M. DiFurio, Megan J. TI Imager detected cases versus historical manual screening SO CANCER CYTOPATHOLOGY LA English DT Meeting Abstract C1 [Duby, Jeanne M.; DiFurio, Megan J.] Brooke Army Med Ctr, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER CYTOPATHOL JI Cancer Cytopathol. PD OCT 25 PY 2007 VL 111 IS 5 SU S MA 34 BP 374 EP 375 PG 2 WC Oncology; Pathology SC Oncology; Pathology GA 222YV UT WOS:000250335700049 ER PT J AU Rice, BM Hare, JJ Byrd, EFC AF Rice, Betsy M. Hare, Jennifer J. Byrd, Edward F. C. TI Accurate predictions of crystal densities using quantum mechanical molecular volumes SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID IONIC LIQUIDS; SURFACE-AREA; NITRAMINES; SALTS; CHEMISTRY; FORMULA AB A quantum mechanically based procedure for estimation of crystal densities of neutral and ionic crystals is presented. In this method, volumes within 0.001 electrons/bohr(3) isosurfaces of electron density for the constituent isolated neutral and ionic molecules are calculated to define the molecular volume or formula unit volumes used in predicting the crystal density. The B3LYP density functional theory in conjunction with the 6-31G** basis set were employed to generate the electron densities. The suitability of this method of crystal density prediction was assessed by subjecting a large number (289) of molecular and ionic crystals to the procedure and comparing results with experimental information. The results indicate that, for neutral molecular crystals, the root-mean-square (rms) deviation from experiment is within 4%, whereas the rms deviation is somewhat larger for the 71 ionic crystals evaluated (within 5%). C1 [Rice, Betsy M.; Hare, Jennifer J.; Byrd, Edward F. C.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Rice, BM (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM betsyr@arl.army.mil NR 45 TC 75 Z9 81 U1 3 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD OCT 25 PY 2007 VL 111 IS 42 BP 10874 EP 10879 DI 10.1021/jp073117j PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 245PP UT WOS:000251947900054 PM 17914760 ER PT J AU Warfield, KL Alves, DA Bradfute, SB Reed, DK VanTongeren, S Kalina, WV Olinger, GG Bavari, S AF Warfield, Kelly L. Alves, Derron A. Bradfute, Steven B. Reed, Daniel K. VanTongeren, Sean Kalina, Warren V. Olinger, Gene G. Bavari, Sina TI Development of a model for marburgvirus based on severe-combined immunodeficiency mice SO VIROLOGY JOURNAL LA English DT Article ID EBOLA HEMORRHAGIC-FEVER; VIRUS-INFECTION; VP35 PROTEIN; BIOLOGICAL WEAPONS; RHESUS-MONKEYS; GUINEA-PIGS; PATHOGENESIS; TRANSMISSION; PROPHYLAXIS; FILOVIRUSES AB The filoviruses, Ebola (EBOV) and Marburg (MARV), cause a lethal hemorrhagic fever. Human isolates of MARV are not lethal to immmunocompetent adult mice and, to date, there are no reports of a mouse-adapted MARV model. Previously, a uniformly lethal EBOV-Zaire mouse-adapted virus was developed by performing 9 sequential passages in progressively older mice (suckling to adult). Evaluation of this model identified many similarities between infection in mice and nonhuman primates, including viral tropism for antigen-presenting cells, high viral titers in the spleen and liver, and an equivalent mean time to death. Existence of the EBOV mouse model has increased our understanding of host responses to filovirus infections and likely has accelerated the development of countermeasures, as it is one of the only hemorrhagic fever viruses that has multiple candidate vaccines and therapeutics. Here, we demonstrate that serially passaging liver homogenates from MARV-infected severe combined immunodeficient ( scid) mice was highly successful in reducing the time to death in scid mice from 50-70 days to 7-10 days after MARV-Ci67, -Musoke, or -Ravn challenge. We performed serial sampling studies to characterize the pathology of these scid mouse-adapted MARV strains. These scid mouse-adapted MARV models appear to have many similar properties as the MARV models previously developed in guinea pigs and nonhuman primates. Also, as shown here, the scid-adapted MARV mouse models can be used to evaluate the efficacy of candidate antiviral therapeutic molecules, such as phosphorodiamidate morpholino oligomers or antibodies. C1 [Warfield, Kelly L.; Alves, Derron A.; Bradfute, Steven B.; Reed, Daniel K.; VanTongeren, Sean; Kalina, Warren V.; Olinger, Gene G.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Warfield, KL (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM kelly.warfield@us.army.mil; derron.alves@us.army.mil; steven.bradfute@us.army.mil; daniel.kenyon.reed@us.army.mil; sean.vantongeren@us.army.mil; warren.kalina@us.army.mil; gene.olinger@amedd.army.mil; sina.bavari@us.army.mil OI Olinger, Gene/0000-0001-7338-0292 NR 41 TC 36 Z9 37 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD OCT 25 PY 2007 VL 4 AR 108 DI 10.1186/1743-422X-4-108 PG 13 WC Virology SC Virology GA 250AI UT WOS:000252272000002 PM 17961252 ER PT J AU Morozov, VN Groves, S Turell, MJ Bailey, C AF Morozov, Victor N. Groves, Stephanie Turell, Michael J. Bailey, Charles TI Three minutes-long electrophoretically assisted zeptornolar microfluidic immunoassay with magnetic-beads detection SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID ELECTROSPRAY DEPOSITION; PROTEIN MICROARRAYS AB An ultrasensitive, two-step immunoassay method was developed for rapid assay of proteins and viruses. In the first step, electrophoresis was used to quickly bring soluble analytes from a flowing solution to a microarray of probe molecules immobilized on a semipermeable membrane. In the second step, the captured analyte was detected by scanning the microarray with functionalized magnetic beads passed over the array surface by shear flow and pressed to the array surface by a magnetic field. We demonstrated that this method routinely detected analytes in concentrations as low as 20 aM (500-1000 molecules, or 1-2 zeptamoles) within 2-3 min in the presence of a similar to 10(11)-fold excess of other protein molecules in the sample. C1 George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA 20110 USA. Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Morozov, VN (reprint author), George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA 20110 USA. EM vmorozov@gmu.edu NR 15 TC 59 Z9 60 U1 7 U2 27 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD OCT 24 PY 2007 VL 129 IS 42 BP 12628 EP + DI 10.1021/ja075069m PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 222VY UT WOS:000250327000021 PM 17902669 ER PT J AU Weiss, WR Kumar, A Jiang, G Williams, J Bostick, A Conteh, S Fryauff, D Aguiar, J Singh, M O'Hagan, DT Ulmer, JB Richie, TL AF Weiss, Walter R. Kumar, Anita Jiang, George Williams, Jackie Bostick, Anthony Conteh, Solomon Fryauff, David Aguiar, Joao Singh, Manmohan O'Hagan, Derek T. Ulmer, Jeffery B. Richie, Thomas L. TI Protection of Rhesus Monkeys by a DNA Prime/Poxvirus Boost Malaria Vaccine Depends on Optimal DNA Priming and Inclusion of Blood Stage Antigens SO PLOS ONE LA English DT Article AB Background. We have previously described a four antigen malaria vaccine consisting of DNA plasmids boosted by recombinant poxviruses which protects a high percentage of rhesus monkeys against Plasmodium knowlesi (Pk) malaria. This is a multi-stage vaccine that includes two pre-erythrocytic antigens, PkCSP and PkSSP2(TRAP), and two erythrocytic antigens, PkAMA-1 and PkMSP-1(42kD). The present study reports three further experiments where we investigate the effects of DNA dose, timing, and formulation. We also compare vaccines utilizing only the pre-erythrocytic antigens with the four antigen vaccine. Methodology. In three experiments, rhesus monkeys were immunized with malaria vaccines using DNA plasmid injections followed by boosting with poxvirus vaccine. A variety of parameters were tested, including formulation of DNA on poly-lactic co-glycolide (PLG) particles, varying the number of DNA injections and the amount of DNA, varying the interval between the last DNA injection to the poxvirus boost from 7 to 21 weeks, and using vaccines with from one to four malaria antigens. Monkeys were challenged with Pk sporozoites given iv 2 to 4 weeks after the poxvirus injection, and parasitemia was measured by daily Giemsa stained blood films. Immune responses in venous blood samples taken after each vaccine injection were measured by ELIspot production of interferon-gamma, and by ELISA. Conclusions. 1) the number of DNA injections, the formulation of the DNA plasmids, and the interval between the last DNA injection and the poxvirus injection are critical to vaccine efficacy. However, the total dose used for DNA priming is not as important; 2) the blood stage antigens PkAMA-1 and PkMSP-1 were able to protect against high parasitemias as part of a genetic vaccine where antigen folding is not well defined; 3) immunization with PkSSP2 DNA inhibited immune responses to PkCSP DNA even when vaccinations were given into separate legs; and 4) in a counter-intuitive result, higher interferon-gamma ELIspot responses to the PkCSP antigen correlated with earlier appearance of parasites in the blood, despite the fact that PkCSP vaccines had a protective effect. C1 [Weiss, Walter R.; Kumar, Anita; Jiang, George; Conteh, Solomon; Fryauff, David; Aguiar, Joao; Richie, Thomas L.] USN, Med Res Ctr, Silver Spring, MD USA. [Williams, Jackie; Bostick, Anthony] Walter Reed Army Inst Res, Silver Spring, MD USA. [Singh, Manmohan; O'Hagan, Derek T.; Ulmer, Jeffery B.] Chiron Corp, Emeryville, CA 94608 USA. RP Weiss, WR (reprint author), USN, Med Res Ctr, Silver Spring, MD USA. EM weissw@nmrc.navy.mil OI Richie, Thomas/0000-0002-2946-5456 FU DOD funds allocated to the Naval Medical Research Center [6000.RAD1.F.A0309] FX This work was supported by DOD funds allocated to the Naval Medical Research Center (work unit number 6000.RAD1.F.A0309). NR 66 TC 26 Z9 27 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 24 PY 2007 VL 2 IS 10 AR e1063 DI 10.1371/journal.pone.0001063 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA V10IU UT WOS:000207458500010 PM 17957247 ER PT J AU Luo, CY Tong, M Chilukuri, N Brecht, K Maxwell, DM Saxena, A AF Luo, Chunyuan Tong, Min Chilukuri, Nageswararao Brecht, Karen Maxwell, Donald M. Saxena, Ashima TI An in vitro comparative study on the reactivation of nerve agent-inhibited guinea pig and human acetylcholinesterases by oximes SO BIOCHEMISTRY LA English DT Article ID DIFFERENT ORGANOPHOSPHORUS COMPOUNDS; BRAIN ACETYLCHOLINESTERASE; STEREOSPECIFIC REACTIVATION; CRYSTAL-STRUCTURES; PYRIDINIUM SALTS; AGING KINETICS; SOMAN; TABUN; HI-6; PROTECTION AB The reactivation of nerve agent-inhibited acetylcholinesterase (AChE) by oxime is the most important step in the treatment of nerve agent poisoning. Since the evaluation of nerve agent antidotes cannot be conducted in humans, results from animal experiments are extrapolated to humans. Guinea pig is one of the animal models that is frequently used for conducting nerve agent antidote evaluations. Several investigations have demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate nerve agent-inhibited AChE. If the in vitro oxime reactivation of nerve agent-inhibited animal AChE is similar to that of human AChE, it is likely that the results of an in vivo animal study will reliably extrapolate to humans. Therefore, the goal of this study was to compare the reactivation of guinea pig and human AChEs inhibited by six different G and V type nerve agents. Reactivation kinetic studies with five mono- and bis-pyridinium oximes showed that oxime reactivation of nerve agent-inhibited human AChE in most cases was faster than guinea pig AChE. The most significant enhancement was observed in the reactivation of human AChE inhibited by nerve agents containing bulky side chains GF, GD, and VR, by H-series oximes HLo-7, HI-6, and ICD-585. In these cases, species-related differences observed between the two AChEs, based on the second-order reactivation rate constants, were 90- to over 400-fold. On the other hand, less than 3-fold differences were observed in the rates of aging of nerve agent-inhibited guinea pig and human AChEs. These results suggest that the remarkable species-related differences observed in the reactivation of nerve agent-inhibited guinea pig and human AChEs were not due to differences in the rates of aging. These results also suggest that guinea pig may not be an appropriate animal model for the in vivo evaluation of oxime therapy. C1 Walter Reed Army Inst Res, Dept Mol Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. US Army Med Res, Inst Chem Defense, Edgewood, MD 21010 USA. RP Luo, CY (reprint author), Walter Reed Army Inst Res, Dept Mol Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. NR 46 TC 47 Z9 48 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD OCT 23 PY 2007 VL 46 IS 42 BP 11771 EP 11779 DI 10.1021/bi701002f PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 221LI UT WOS:000250228400011 PM 17900152 ER PT J AU Zeng, MT Xu, QF Elias, M Pichichero, ME Simpson, LL Smith, LA AF Zeng, Mingtao Xu, Qingfu Elias, Md. Pichichero, Michael E. Simpson, Lance L. Smith, Leonard A. TI Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine SO VACCINE LA English DT Article DE botulism vaccine; protective immunity; replication-incompetent adenovirus ID EQUINE ENCEPHALITIS-VIRUS; NEUROTOXIN SEROTYPE-A; ANTHRAX LETHAL TOXIN; CLOSTRIDIUM-BOTULINUM; H-C; ESCHERICHIA-COLI; BINDING DOMAIN; GENE SYNTHESIS; TETANUS TOXIN; T-CELLS AB Botulinum neurotoxins cause botulism, a neuroparalytic disease in humans and animals. We constructed a replication-incompetent adenovirus encoding a synthesized codon-optimized gene for expression of the heavy chain C-fragment (H(C)50) of botulinum neurotoxin type C (BoNT/C). This recombinant human serotype 5 adenoviral vector (Ad5) was evaluated as a genetic vaccine candidate against botulism caused by BoNT/C in a mouse model. A one-time intramuscular injection with 10(5) to 2 x 10(7) pfu of adenoviral vectors elicited robust serum antibody responses against Hc50 of BoNT/C as assessed by ELISA. Immune sera showed high potency in neutralizing the active BoNT/C in vitro. After a single dose of 2 x 10(7) pfu adenoviral vectors, the animals were completely protected against intraperitoneal challenge with 100 x MLD50 of active BoNT/C. The protective immunity appeared to be vaccine dose-dependent. The anti-toxin protective immunity could last for at least 7 months without a booster injection. In addition, we observed that pre-existing immunity to the wild-type Ad5 in the host had no significant influence on the protective efficacy of vaccination. The data suggest that an adenovirus-vectored genetic vaccine is a highly efficient prophylaxis candidate against botulism. (c) 2007 Elsevier Ltd. All rights reserved. C1 Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA. Thomas Jefferson Univ, Jefferson Med Coll, Dept Med, Philadelphia, PA 19107 USA. Thomas Jefferson Univ, Jefferson Med Coll, Dept Biochem & Mol Biol, Philadelphia, PA 19107 USA. USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Zeng, MT (reprint author), Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Box 672,601 Elmwood Ave, Rochester, NY 14642 USA. EM Mingtao_Zeng@urmc.rochester.edu RI Xu, Qingfu/A-1597-2011 OI Xu, Qingfu/0000-0002-1957-8502 FU NIAID NIH HHS [R21 AI055946-01, R21 AI055946, N01AI30028, AI055946, R21 AI055946-02]; NIGMS NIH HHS [GM57345]; NINDS NIH HHS [R01 NS022153-23, NS022153, R01 NS022153-22, R01 NS022153] NR 47 TC 22 Z9 22 U1 2 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 23 PY 2007 VL 25 IS 43 BP 7540 EP 7548 DI 10.1016/j.vaccine.2007.08.035 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 230QV UT WOS:000250891900008 PM 17897756 ER PT J AU Krapels, K Driggers, RG Deaver, D Moyer, SK Palmer, J AF Krapels, Keith Driggers, Ronald G. Deaver, Dawne Moyer, Steven K. Palmer, John TI Midwave infrared and visible sensor performance modeling: small craft identification discrimination criteria for maritime security SO APPLIED OPTICS LA English DT Article ID TARGET ACQUISITION PERFORMANCE; CYCLE CRITERIA AB The new emphasis on Anti-Terrorism and Force Protection (AT/FP), for both shore and sea platform protection, has resulted in a need for infrared imager design and evaluation tools that demonstrate field performance against U.S. Navy AT/FP requirements. In the design of infrared imaging systems for target acquisition, a discrimination criterion is required for successful sensor realization. It characterizes the difficulty of the task being performed by the observer and varies for different target sets. This criterion is used in both assessment of existing infrared sensor and in the design of new conceptual sensors. We collected 12 small craft signatures (military and civilian) in the visible band during the day and the long-wave and midwave infrared spectra in both the day and the night environments. These signatures were processed to determine the targets' characteristic dimension and contrast. They were also processed to band limit the signature's spatial information content (simulating longer range), and a perception experiment was performed to determine the task difficulty (N-50 and V-50). The results are presented and can be used for Navy and Coast Guard imaging infrared sensor design and evaluation. (c) 2007 Optical Society of America C1 Off Naval Res, One Liberty Ctr, Arlington, VA 22203 USA. USA, Army Night Vis & Electron Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Krapels, K (reprint author), Off Naval Res, One Liberty Ctr, 875 N Randolf St, Arlington, VA 22203 USA. EM krapelk@onr.navy.mil NR 8 TC 15 Z9 16 U1 0 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 2007 VL 46 IS 30 BP 7345 EP 7353 DI 10.1364/AO.46.007345 PG 9 WC Optics SC Optics GA 232VC UT WOS:000251047200001 PM 17952168 ER PT J AU Zakharov, VE Korotkevich, AO Pushkarev, A Resio, D AF Zakharov, V. E. Korotkevich, A. O. Pushkarev, A. Resio, D. TI Coexistence of weak and strong wave turbulence in a swell propagation SO PHYSICAL REVIEW LETTERS LA English DT Article ID CAPILLARY WAVES; ENERGY-TRANSFER; GRAVITY-WAVES; SURFACE AB By performing two parallel numerical experiments - solving the dynamical Hamiltonian equations and solving the Hasselmann kinetic equation - we examined the applicability of the theory of weak turbulence to the description of the time evolution of an ensemble of free surface waves (a swell) on deep water. We observed qualitative coincidence of the results. To achieve quantitative coincidence, we augmented the kinetic equation by an empirical dissipation term modeling the strongly nonlinear process of white capping. Fitting the two experiments, we determined the dissipation function due to wave breaking and found that it depends very sharply on the parameter of nonlinearity (the surface steepness). The onset of white capping can be compared to a second-order phase transition. The results corroborate the experimental observations of Banner, Babanin, and Young [J. Phys. Oceanogr. 30, 3145 (2000)]. C1 Univ Arizona, Dept Math, Tucson, AZ 85721 USA. PN Lebedev Phys Inst, Moscow 119991, Russia. Waves & Solitons LLC, Phoenix 85045, AZ USA. Russian Acad Sci, LD Landau Inst Theoret Phys, Moscow 119334, Russia. US Army Engr Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Zakharov, VE (reprint author), Univ Arizona, Dept Math, 617 N Santa Rita Ave,PO Box 210089, Tucson, AZ 85721 USA. RI Zakharov, Vladimir/F-1461-2016; Zakharov, Vladimir/G-7276-2016; Pushkarev, Andrei/I-8290-2016; OI Pushkarev, Andrei/0000-0001-9310-5888; zakharov, vladimir/0000-0001-8855-7185 NR 21 TC 18 Z9 19 U1 0 U2 1 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD OCT 19 PY 2007 VL 99 IS 16 AR 164501 DI 10.1103/PhysRevLett.99.164501 PG 4 WC Physics, Multidisciplinary SC Physics GA 222KT UT WOS:000250296000034 PM 17995256 ER PT J AU Lindsay, GA Guenthner, AJ Wright, ME Sanhadasa, M Ashley, PR AF Lindsay, Geoffrey A. Guenthner, Andrew J. Wright, Michael E. Sanhadasa, Mohan Ashley, Paul R. TI Multi-month thermal aging of electro-optic polymer waveguides: Synthesis, fabrication, and relaxation modeling SO POLYMER LA English DT Article DE aging; chromophore; nonlinear optic ID NONLINEAR-OPTICAL POLYMERS; TEMPERATURE-DEPENDENCE; CHROMOPHORE; GLASSES; STABILITY; DYNAMICS; FILMS; MOLECULES; DECAY AB The preparation of polyimides containing side-chain chromophores and the long-term aging performance of poled films are described. These materials were compared to guest-host polycarbonate films. Mach-Zehnder optical interferometers were fabricated from these polymers that contained CLD- and FTC-type chromophores. Changes in optical properties were monitored for months at four temperatures ranging from ambient to 110 degrees C. The isothermal relaxation data were modeled using both a stretched exponential equation and a power law in time equation. The temperature dependency of the time constants of these equations was modeled using a new activation-energy equation: In(tau/tau(p)) = E(R)(1 + tanh[(T(c) - T)/D])/2RT + E(p)/RT where T(c) is the central temperature of the transition zone, D is the breadth of the zone, and Es are the activation energies of rigid and pliable materials. Multi-year high-temperature stability of the poled guest-host and side-chain materials was predicted. (C) 2007 Elsevier Ltd. All rights reserved. C1 USN, NAVAIR, Div Chem, China Lake, CA 93555 USA. AEgis Technol Grp Inc, Huntsville, AL 35806 USA. USA, AMRDEC, RD&E Command, Redstone Arsenal, AL 35898 USA. RP Lindsay, GA (reprint author), USN, NAVAIR, Div Chem, China Lake, CA 93555 USA. EM geoffrey.lindsay@navy.mil NR 47 TC 12 Z9 12 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD OCT 19 PY 2007 VL 48 IS 22 BP 6605 EP 6616 DI 10.1016/j.polymer.2007.08.057 PG 12 WC Polymer Science SC Polymer Science GA 230TU UT WOS:000250899600015 ER PT J AU Terzic, N Opsenica, D Milic, D Tinant, B Smith, KS Milhous, WK Solaja, BA AF Terzic, Natasa Opsenica, Dejan Milic, Dragana Tinant, Bernard Smith, Kirsten S. Milhous, Wilbur K. Solaja, Bogdan A. TI Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID ARTEMISININ DERIVATIVES; TRIOXANE DIMERS; IN-VITRO; 1,2,4,5-TETRAOXANES; ANTIMYCOBACTERIAL; ANTICANCER; MECHANISMS; RESISTANCE; EFFICACY; GROWTH AB The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively. C1 Inst Chem Technol & Met, Belgrade, Serbia. Catholic Univ Louvain, Lab Chim Phys Cristallograh, B-3000 Louvain, Belgium. Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA. Univ Belgrade, Fac Chem, Belgrade, Serbia. RP Solaja, BA (reprint author), Inst Chem Technol & Met, Belgrade, Serbia. EM bsolaja@chem.bg.ac.yu RI Milic, Dragana/G-7083-2012; OI Milic, Dragana/0000-0002-5713-8815; Solaja, Bogdan/0000-0002-9975-2725 NR 32 TC 57 Z9 58 U1 2 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD OCT 18 PY 2007 VL 50 IS 21 BP 5118 EP 5127 DI 10.1021/jm070684m PG 10 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 219TI UT WOS:000250110700009 PM 17887664 ER PT J AU Schill, AW Heaps, DA Stratis-Cullum, DN Arnold, BR Pellegrino, PM AF Schill, Alexander W. Heaps, David A. Stratis-Cullum, Dimitra N. Arnold, Bradley R. Pellegrino, Paul M. TI Characterization of near-infrared low energy ultra-short laser pulses for portable applications of laser induced breakdown spectroscopy SO OPTICS EXPRESS LA English DT Article ID MICROCHIP-LASER; FEMTOSECOND LASER; QUANTITATIVE-ANALYSIS; LIBS; NANOSECOND; ABLATION; PICOSECOND; EMISSION; SENSOR; SPECTROMETRY AB We report on the delivery of low energy ultra-short (< 1 ps) laser pulses for laser induced breakdown spectroscopy ( LIBS). Ultra-short pulses have the advantage of high peak irradiance even at very low pulse energies. This opens the possibility to use compact, rare-earth doped fiber lasers in a portable platform for point detection applications using LIBS for elemental analysis. The use of low energy ultra-short pulses minimizes the generation of a broad continuum background in the emission spectrum, which permits the use of non-gated detection schemes using very simple and compact spectrometers. The pulse energies used to produce high-quality LIBS spectra in this investigation are some of the lowest reported and we investigate the threshold pulse requirements for a number of near IR pulse wavelengths ( 785-1500 nm) and observe that the pulse wavelength has no effects on the threshold for observation of plasma emission or the quality of the emission spectra obtained. (c) 2007 Optical Society of America. C1 USA, Res Lab, Adelphi, MD 20783 USA. Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA. RP Pellegrino, PM (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ppellegr@arl.army.mil NR 50 TC 6 Z9 6 U1 1 U2 10 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD OCT 17 PY 2007 VL 15 IS 21 BP 14044 EP 14056 DI 10.1364/OE.15.014044 PG 13 WC Optics SC Optics GA 235HA UT WOS:000251223100062 PM 19550677 ER PT J AU Tunick, A AF Tunick, Arnold TI Statistical analysis of measured free-space laser signal intensity over a 2.33 km optical path SO OPTICS EXPRESS LA English DT Article ID NON-KOLMOGOROV TURBULENCE; WAVE-FRONT SENSOR; ATMOSPHERIC-TURBULENCE; A-LOT; BEAM; PROPAGATION; COMMUNICATION; SCINTILLATION; FLUCTUATIONS; SPECTRA AB Experimental research is conducted to determine the characteristic behavior of high frequency laser signal intensity data collected over a 2.33 km optical path. Results focus mainly on calculated power spectra and frequency distributions. In addition, a model is developed to calculate optical turbulence intensity (C-n(2)) as a function of receiving and transmitting aperture diameter, log-amplitude variance, and path length. Initial comparisons of calculated to measured C-n(2) data are favorable. It is anticipated that this kind of signal data analysis will benefit laser communication systems development and testing at the U. S. Army Research Laboratory (ARL) and elsewhere. (c) 2007 Optical Society of America. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Tunick, A (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM atunick@arl.army.mil NR 26 TC 13 Z9 13 U1 1 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD OCT 17 PY 2007 VL 15 IS 21 BP 14115 EP 14122 DI 10.1364/OE.15.014115 PG 8 WC Optics SC Optics GA 235HA UT WOS:000251223100069 PM 19550684 ER PT J AU Gurusamy, N Gorbunov, N Das, DK AF Gurusamy, Narasimman Gorbunov, Nikolai Das, Dipalk K. TI Ischemic preconditioning of the myocardium augments autophagy in association with BAG-1 protein SO CIRCULATION LA English DT Meeting Abstract CT 80th Annual Scientific Session of the American-Heart-Association CY NOV 04-07, 2007 CL Orlando, FL SP Amer Heart Assoc C1 [Gurusamy, Narasimman; Das, Dipalk K.] Univ Connecticut, Ctr Hlth, Farmington, CT USA. [Gorbunov, Nikolai] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 16 PY 2007 VL 116 IS 16 SU S MA 1259 BP 256 EP 256 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 223TD UT WOS:000250394301186 ER PT J AU Wang, TY Roe, MT Dai, D Peterson, ED Dixon, WC AF Wang, Tracy Y. Roe, Matthew T. Dai, David Peterson, Eric D. Dixon, William C. CA Natl Cardiovascular Data Registry TI Anatomic distribution of culprit lesions in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention SO CIRCULATION LA English DT Meeting Abstract CT 80th Annual Scientific Session of the American-Heart-Association CY NOV 04-07, 2007 CL Orlando, FL SP Amer Heart Assoc C1 [Wang, Tracy Y.; Roe, Matthew T.; Dai, David; Peterson, Eric D.] Duke Univ, Durham, NC 27706 USA. [Dixon, William C.] Dwight D Eissenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 16 PY 2007 VL 116 IS 16 MA 1802 BP 383 EP 384 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 223TD UT WOS:000250394301722 ER PT J AU Taylor, AJ Feuerstein, IM Bindeman, J Wu, H Bauer, K Byrd, C O'Malley, PG AF Taylor, Allen J. Feuerstein, Irwin M. Bindeman, Jody Wu, Holly Bauer, Kelly Byrd, Carole O'Malley, Patrick G. TI Coronary calcium screening for CHD risk assessment: For intermediate risk only? Findings in low-risk men and women SO CIRCULATION LA English DT Meeting Abstract CT 80th Annual Scientific Session of the American-Heart-Association CY NOV 04-07, 2007 CL Orlando, FL SP Amer Heart Assoc C1 [Taylor, Allen J.; Feuerstein, Irwin M.; Bindeman, Jody; Wu, Holly; Bauer, Kelly; Byrd, Carole; O'Malley, Patrick G.] Walter Reed Army Med Ctr, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 16 PY 2007 VL 116 IS 16 SU S MA 3410 BP 770 EP 770 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 223TD UT WOS:000250394303505 ER PT J AU Taylor, AJ Feuerstein, IM Wu, H Bindeman, J Bauer, K Byrd, C O'Malley, PG AF Taylor, Allen J. Feuerstein, Irwin M. Wu, Holly Bindeman, Jody Bauer, Kelly Byrd, Carole O'Malley, Patrick G. TI Using the Framingham risk score to select low-risk men for CAC screening SO CIRCULATION LA English DT Meeting Abstract CT 80th Annual Scientific Session of the American-Heart-Association CY NOV 04-07, 2007 CL Orlando, FL SP Amer Heart Assoc C1 [Taylor, Allen J.; Feuerstein, Irwin M.; Wu, Holly; Bindeman, Jody; Bauer, Kelly; Byrd, Carole; O'Malley, Patrick G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 16 PY 2007 VL 116 IS 16 MA 3719 BP 845 EP 845 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 223TD UT WOS:000250394303810 ER PT J AU Batchinsky, A Freeman, J Panasyuk, S Jordan, B Martini, D Neverov, M Schomacker, K Cancio, L AF Batchinsky, Andriy Freeman, Jenny Panasyuk, Svetlana Jordan, Bryon Martini, David Neverov, Marie Schomacker, Kevin Cancio, Leopoldo TI Use of medical hyperspectral imaging in the evaluation of blunt chest trauma and hemorrhagic shock in a porcine model SO CIRCULATION LA English DT Meeting Abstract CT 80th Annual Scientific Session of the American-Heart-Association CY NOV 04-07, 2007 CL Orlando, FL SP Amer Heart Assoc C1 [Batchinsky, Andriy; Jordan, Bryon; Martini, David; Cancio, Leopoldo] Brooke Army Med Ctr, Inst Surg Res, San Antonio, TX USA. [Freeman, Jenny; Panasyuk, Svetlana; Neverov, Marie; Schomacker, Kevin] HyperMed Inc, Waltham, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 16 PY 2007 VL 116 IS 16 SU S MA 114 BP 947 EP 947 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 223TD UT WOS:000250394303998 ER PT J AU Choudhury, ND Wilhelm, WE Rao, B Gott, J Khotekar, N AF Choudhury, Nilanjan D. Wilhelm, Wilbert E. Rao, Brijesh Gott, Jonathan Khotekar, Nikhilesh TI Process planning for circuit card assembly on a series of dual head placement machines SO EUROPEAN JOURNAL OF OPERATIONAL RESEARCH LA English DT Article DE heuristics; integer programming; assembly line balancing; circuit card assembly; process planning ID SEQUENCE-DEPENDENT SETUP; COMPONENT ALLOCATION; OPERATIONS; STRATEGIES; CELL AB This paper proposes an approach for prescribing the inter-related decisions that prescribe a process plan for a series of dual head placement machines. The goal is to provide a means of rapidly prescribing a process plan that seeks to minimize cycle time (equivalently, maximize throughput rate) by balancing workloads assigned to heads when assembling a given type of circuit card. Our approach decomposes process planning decisions into four related problems. This paper explores list-processing heuristics for the first of these problems and adapts an optimizing method for the fourth. It also integrates these two methods with others to optimize the second and third of these problems, reporting computational tests that evaluate the overall approach to all four problems and assessing the degree to which the decomposition approach is able to balance workloads assigned and the run time required to do so. Resulting cycle times are also analyzed. These test results demonstrate that the overall approach provides a means of prescribing effective process plans within a run time acceptable to process planners. (C) 2006 Elsevier B.V. All rights reserved. C1 Texas A&M Univ, Dept Ind Engn, College Stn, TX 77843 USA. USA, Atlanta, GA USA. Dash Optimizat, Englewood Cliffs, NJ 07632 USA. HSBC, Chicago, IL USA. RP Wilhelm, WE (reprint author), Texas A&M Univ, Dept Ind Engn, TAMUS 3131, College Stn, TX 77843 USA. EM nilanjan.d.chowdhury@us.hsbc.com; wilhelm@tamu.edu NR 35 TC 5 Z9 6 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-2217 J9 EUR J OPER RES JI Eur. J. Oper. Res. PD OCT 16 PY 2007 VL 182 IS 2 BP 626 EP 639 DI 10.1016/j.ejor.2006.08.059 PG 14 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA 174XG UT WOS:000246975600010 ER PT J AU Waag, DM AF Waag, David M. TI Coxiella burnetii: Host and bacterial responses to infection SO VACCINE LA English DT Review DE Q fever; vaccine; Coxiella; immune response; infection; immunomodulation ID Q-FEVER ENDOCARDITIS; METHANOL RESIDUE VACCINE; PHASE-I; FOLLOW-UP; Q-VAX; SUPEROXIDE-DISMUTASE; COMPARATIVE EFFICACY; CELLULAR-IMMUNITY; FATIGUE SYNDROME; SCN MICE AB Designation as a Category B biothreat agent has propelled Coxiella burnetii from a relatively obscure, underappreciated, "niche" microor-Ganism on the periphery of bacteriology, to one of possibly great consequence if actually used in acts of bioterrorism. Advances in the study of this microorganism proceeded slowly, primarily because of the difficulty in studying this obligate intracellular pathogen that must be manipulated under biosafety level-3 conditions. The dogged determination of past and current C. burnetii researchers and the application of modem immunological and molecular techniques have more clearly defined the host and bacterial response to infection. This review is intended to provide a basic introduction to C. burnetii and Q fever, while emphasizing immunomodulatory properties, both positive and negative, of Q fever vaccines and C. burnetii infections. Published by Elsevier Ltd. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Waag, DM (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. EM david.waag@amedd.army.mil NR 99 TC 24 Z9 27 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 16 PY 2007 VL 25 IS 42 BP 7288 EP 7295 DI 10.1016/j.vaccine.2007.08.002 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 227JV UT WOS:000250653900003 PM 17825460 ER PT J AU Watson, HE Davis, JM Synovec, RE AF Watson, Hathanial E. Davis, Joe M. Synovec, Robert E. TI Observations on "orthogonality" in comprehensive two-dimensional separations SO ANALYTICAL CHEMISTRY LA English DT Article ID LIQUID-CHROMATOGRAPHY; RATIO AB The concept and definition of orthogonality in the context of comprehensive two-dimensional (2D) separations are interesting topics of active discussion. Over the years, several approaches have been taken to quantify the degree of orthogonality, primarily to serve as a metric to optimize (and compare) comprehensive 2D separations. Recently, a mathematical function was reported that is qualitatively instructive for the purpose of providing such a metric. However, the mathematical function has some quantitative shortcomings. Herein, we both explore and partially correct this function. The orthogonality metric, referred to previously and herein as the orthogonality, 0, was mathematically related to the fraction of the 2D separation space occupied by compounds (i.e., fractional coverage) and the peak capacity, P, for one dimension of the 2D separation. The fractional coverage, f, is simply related to the percentage coverage, which is equal to 100%(f). Our main finding was that the values for O as a function of P for a given percentage coverage achieve a constant value at large P but deviate severely to lower O values at small P. For comprehensive 2D separations operated such that the second dimension is at small P, the findings we report have consequences for those who consider applying the O metric. Finally, it is discussed that the percentage coverage may be a better metric to gauge the extent to which the compounds in a given sample mixture have been disseminated in the 2D separation space. C1 Univ Washington, Dept Chem, Seattle, WA 98195 USA. US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. So Illinois Univ, Dept Chem & Biochem, Carbondale, IL 62901 USA. RP Synovec, RE (reprint author), Univ Washington, Dept Chem, Box 351700, Seattle, WA 98195 USA. EM synovec@chem.washington.edu NR 14 TC 20 Z9 20 U1 0 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD OCT 15 PY 2007 VL 79 IS 20 BP 7924 EP 7927 DI 10.1021/ac0710578 PG 4 WC Chemistry, Analytical SC Chemistry GA 220QW UT WOS:000250173200045 ER PT J AU Kim, EJ Kramer, SF Hebert, CG Valdes, JJ Bentley, WE AF Kim, Eun Jeong Kramer, Shannon F. Hebert, Colin G. Valdes, James J. Bentley, William E. TI Metabolic engineering of the baculovirus-expression system via inverse "Shotgun" genomic analysis and RNA interference (dsRNA) increases product yield and cell longevity SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article DE RNA interference; dsRNA; caspase; apoptosis; cathepsin; baculovirus expression vector systems; Trichoplusia ni larvae; Spodoptera frugiperda cells; metabolic engineering ID GREEN FLUORESCENT PROTEIN; TRICHOPLUSIA-NI LARVAE; HAMSTER OVARY CELLS; DOUBLE-STRANDED-RNA; DOWN-REGULATION; INSECT CELLS; CHO-CELLS; IN-VIVO; INDUCED APOPTOSIS; MAMMALIAN-CELLS AB RNA interference (RNAi) is as powerful tool for characterizing gene function in eukaryotic organisms and cultured cell lines. Its use in metabolic engineering has been limited and few reports have targeted protein expression systems to increase yield. In this work, we examine the use of in vitro synthesized double stranded RNA (dsRNA) in the baculovirus expression vector system (BEVS), using commercially relevant cultured cells (Spodoptera frugiperda, Sf-9) and larvae (Trichoplusia ni) as hosts. First, we employed an inverse "shotgun" genomic analysis to "find" an array of 16 putative insect gene targets. We then synthesized dsRNA in vitro targeting these genes and investigated the effects of injected dsRNA on larval growth, development, and product yield. Growth and development was at times stunted and in several cases, the effects were lethal. However, dsRNA targeting an acidic juvenile hormone-suppressible protein (AJHSP1), and translational elongation factor 2 (Ef-2) resulted in significantly increased yield of model product, GFP. Next, we targeted known genes, v-cath and apoptosis inducer, sf-caspase 1, in cultured Sf-9 cells. We confirm RNAi-mediated sf-caspase 1 suppression in Sf-9 cells, but not in baculovirus-infected cells, likely due to the overriding effects of inhibitor of apoptosis protein, p35. We also demonstrate suppression of v-cath in infected cells, which leads to a similar to 3-fold increase in product yield. Overall, our results support the application of RNAi in metabolic engineering, specifically for enhancing protein productivity in the baculovirus expression vector system. C1 Univ Maryland, Ctr Biosyst Res, Inst Biotechnol, College Pk, MD 20742 USA. Texas A&M Univ, Hlth Sci Ctr, Baylor Coll Dent, Dept Biomed Sci, Dallas, TX USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. RP Bentley, WE (reprint author), Univ Maryland, Ctr Biosyst Res, Inst Biotechnol, 5115 Plant Sci Bldg, College Pk, MD 20742 USA. EM bentley@eng.umd.edu FU NIGMS NIH HHS [GM70851-01] NR 45 TC 14 Z9 15 U1 1 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0006-3592 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD OCT 15 PY 2007 VL 98 IS 3 BP 645 EP 654 DI 10.1002/bit.21353 PG 10 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 214ZB UT WOS:000249775800014 PM 17274062 ER PT J AU Mittenclorf, EA Peoples, GE Singletary, SE AF Mittenclorf, Elizabeth A. Peoples, George E. Singletary, S. Eva TI Breast cancer vaccines - Promise for the future or pipe dream? SO CANCER LA English DT Article DE breast cancer; vaccine; therapeutic; prophylactic; DNA vaccines; induced lymphopenia; regulatory T-cells ID ACTIVE SPECIFIC IMMUNOTHERAPY; HER2/NEU E75 VACCINE; MAMMARY-TUMOR VIRUS; REGULATORY T-CELLS; METASTATIC MELANOMA; PERIPHERAL-BLOOD; IMMUNE-RESPONSE; CTLA-4 BLOCKADE; MOUSE; CYCLOPHOSPHAMIDE AB The objective of this study was to review issues involved in the search for a breast cancer vaccine. A review of the recent literature (2004-2007) was undertaken, with earlier literature included as appropriate for background, to assess 1) current approaches being used to create a therapeutic breast cancer vaccine, and 2) potential strategies for a preventive vaccine targeting either an infectious agent or tumor-associated antigen. Several approaches to the development of a therapeutic vaccine show promise, including tumor cell/dendritic cell fusion and DNA vaccines based on single purified antigens or DNA fragments from whole cells. Most of these experimental vaccines have either not moved beyond preclinical. testing or have not shown a significant clinical response. Strategies involving host factors that mitigate immune response against tumors also show promise. Interest has increased in developing a preventive vaccine that can be administered to immunocompetent patients with minimal or no evidence of disease. Prophylactic vaccines typically target infectious agents, but the evidence for an infectious etiology for breast cancer is largely descriptive and difficult to interpret. A second strategy for a preventive breast cancer vaccine is to target tumor-associated antigens. Ongoing clinical trials are utilizing this approach, with preliminary results that are encouraging. C1 Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. Brooke Army Med Ctr, Dept Surg, Houston, TX USA. RP Singletary, SE (reprint author), Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol, 1515 Holcombe Blvd,Box 444, Houston, TX 77030 USA. EM esinglet@mdanderson.org NR 57 TC 30 Z9 30 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD OCT 15 PY 2007 VL 110 IS 8 BP 1677 EP 1686 DI 10.1002/cncr.22978 PG 10 WC Oncology SC Oncology GA 218RT UT WOS:000250033300007 PM 17763371 ER PT J AU Thitithanyanont, A Engering, A Ekchariyawat, P Wiboon-Ut, S Limsalakpetch, A Yongvanitchit, K Kum-Arb, U Kanchongkittiphon, W Utaisincharoen, P Sirisinha, S Puthavathana, P Fukuda, MM Pichyangkul, S AF Thitithanyanont, Arunee Engering, Anneke Ekchariyawat, Peeraya Wiboon-ut, Suwimon Limsalakpetch, Amporn Yongvanitchit, Kosol Kum-Arb, Utaiwan Kanchongkittiphon, Watcharoot Utaisincharoen, Pongsak Sirisinha, Stitaya Puthavathana, Pilaipan Fukuda, Mark M. Pichyangkul, Sathit TI High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-alpha and TLR Ligands SO JOURNAL OF IMMUNOLOGY LA English DT Article ID A H5N1; T-CELLS; CYTOKINE RESPONSES; ADAPTIVE IMMUNITY; HUMAN-DISEASE; RECOGNITION; THAILAND AB There is worldwide concern that the avian influenza H5N1 virus, with a mortality rate of >50%, might cause the next influenza pandemic. Unlike most other influenza infections, H5N1 infection causes a systemic disease. The underlying mechanisms for this effect are still unclear. In this study, we investigate the interplay between avian influenza H5N1 and human dendritic cells (I)Q. We showed that H5N1 virus can infect and replicate in monocyte-derived and blood myeloid DC, leading to cell death. These results suggest that H5N1 escapes viral-specific immunity, and could disseminate via DC. In contrast, blood pDC were resistant to infection and produced high amounts of IFN-alpha. Addition of this cytokine to monocyte-derived DC or pretreatment with TLR ligands protected against infection and the cytopathic effects of H5N1 virus. C1 Armed Forces Res Inst Med Sci, Dept Immunol & Med, USA Med Component, Bangkok 10400, Thailand. Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, USA Army Med Component, Dept Enter Dis, Bangkok 10400, Thailand. Mahidol Univ, Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok 10700, Thailand. RP Pichyangkul, S (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, USA Med Component, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM sathitp@afrims.org FU NIAID NIH HHS [Y1-AI-5026-01] NR 29 TC 67 Z9 71 U1 0 U2 3 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD OCT 15 PY 2007 VL 179 IS 8 BP 5220 EP 5227 PG 8 WC Immunology SC Immunology GA 219QJ UT WOS:000250099400029 PM 17911607 ER PT J AU Hoff, RH Hengge, AC AF Hoff, Richard H. Hengge, Alvan C. TI The use of isotopes in the study of reactions of acyl, phosphoryl, and sulfuryl esters SO JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS LA English DT Review DE kinetic isotope effect; solvent isotope effect; ester; amide; phosphate ester; sulfate ester ID TRANSITION-STATE STRUCTURES; P-NITROPHENYL ACETATE; STRUCTURE REACTIVITY CORRELATIONS; PROTEIN-TYROSINE-PHOSPHATASE; PHENOLATE ION NUCLEOPHILES; BASE-CATALYZED-HYDROLYSIS; ACETYL GROUP TRANSFER; ALKALINE-HYDROLYSIS; STEREOCHEMICAL COURSE; MECHANISTIC IMPLICATIONS AB Acyl, phosphoryl, and sulfuryl transfer reactions involving esters and amides are ubiquitous in the biochemical world, and these reactions are found throughout the biochemical pathways involving proteins, nucleic acids, and other compounds essential for life. Such compounds are also common in commercial chemical processes. The use of isotopes has contributed greatly to our understanding of the chemistry of these compounds. There is an enormous body of literature on the use of isotopes in such studies, and this review does not do justice to this great body of knowledge. We cover a selection of reactions for which multiple experimental applications using isotopes have been used in the advancement of mechanistic studies. Copyright (c) 2007 John Wiley & Sons, Ltd. C1 [Hengge, Alvan C.] Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA. [Hoff, Richard H.] US Mil Acad, Dept Chem, West Point, NY 10996 USA. RP Hengge, AC (reprint author), Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA. EM hengge@cc.usu.edu RI Hengge, Alvan/C-8667-2011 OI Hengge, Alvan/0000-0002-5696-2087 NR 98 TC 2 Z9 3 U1 1 U2 8 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0362-4803 J9 J LABELLED COMPD RAD JI J. Label. Compd. Radiopharm. PD OCT 15 PY 2007 VL 50 IS 11-12 BP 1026 EP 1038 DI 10.1002/jlcr.1433 PG 13 WC Biochemical Research Methods; Chemistry, Medicinal; Chemistry, Analytical SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 249LI UT WOS:000252229400009 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI A shattered peace: Versailles 1919 and the price we pay today SO LIBRARY JOURNAL LA English DT Book Review C1 USA Combined Arms Res Lib, Ft Leavenworth, KS 67801 USA. RP Burgess, EB (reprint author), USA Combined Arms Res Lib, Ft Leavenworth, KS 67801 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2007 VL 132 IS 17 BP 75 EP 75 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 225UG UT WOS:000250542900153 ER PT J AU Kecskes, LJ Cho, KC Dowding, RJ Schuster, BE Valiev, RZ Wei, Q AF Kecskes, L. J. Cho, K. C. Dowding, R. J. Schuster, B. E. Valiev, R. Z. Wei, Q. TI Grain size engineering of bcc refractory metals: Top-down and bottom-up - Application to tungsten SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE grain size effect; ultrafine grain; nanocrystalline; severe plastic deformation; powder metallurgy; dynamic behavior ID SEVERE PLASTIC-DEFORMATION; HIGH-PRESSURE TORSION; BONDING ARB PROCESS; NANOCRYSTALLINE MATERIALS; MECHANICAL-PROPERTIES; NANOSTRUCTURED MATERIALS; ULTRAFINE GRAIN; SINGLE-CRYSTALS; SHEAR BANDS; STRAIN-RATE AB We have used two general methodologies for the production of ultrafine grained (UFG) and nanocrystalline (NC) tungsten (W) metal samples: top-down and bottom-up. In the first, Equal channel angular extrusion (ECAE), coupled with warm rolling has been used to fabricate UFG W, and high pressure torsion (HPT) was used to fabricate NC W. We demonstrate an abrupt shift in the deformation mechanism, particularly under dynamic compressive loading, in UFG and NC W. This novel deformation mechanism, a dramatic transition from a uniform deformation mode to that of localized shearing, is shared by other UFG and NC body-centerd cubic (BCC) metals. We have also conducted a series of bottom-up experiments to consolidate powdered UFG W precursors into solid bodies. The bottom-up approach relies on rapid, high-temperature consolidation, specifically designed for UFG and NC W powders. The mechanical property results from the top-down UFG and NC W were used as minimum property benchmarks to guide and design the experimental protocols and parameters for use in the bottom-up procedures. Preliminary results, showing rapid grain growth during the consolidation cycle, did not achieve full density in the W samples. Further development of high-purity W nanopowders and appropriate grain-growth inhibitors (e.g., Zener pinning) will be required to successfully produce bulk-sized UFG and NC W samples. Published by Elsevier B.V. C1 USA, Res Lab, Weapons & Mat Res Directorate, AMSRD,ARL,WM,MB, Aberdeen Proving Ground, MD 21005 USA. Ufa State Aviat Tech Univ, Inst Phys Adv Mat, Ufa 450000, Russia. Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. RP Kecskes, LJ (reprint author), USA, Res Lab, Weapons & Mat Res Directorate, AMSRD,ARL,WM,MB, Aberdeen Proving Ground, MD 21005 USA. EM kecskes@arl.army.mil RI Wei, Qiuming/B-7579-2008; Kecskes, Laszlo/F-6880-2014; Dowding, Robert/F-1469-2015 OI Kecskes, Laszlo/0000-0002-1342-3729; Dowding, Robert/0000-0002-4763-2131 NR 63 TC 44 Z9 49 U1 2 U2 36 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD OCT 15 PY 2007 VL 467 IS 1-2 BP 33 EP 43 DI 10.1016/j.msea.2007.02.099 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 205WX UT WOS:000249146400005 ER PT J AU Perovich, DK Light, B Eicken, H Jones, KF Runciman, K Nghiem, SV AF Perovich, Donald K. Light, Bonnie Eicken, Hajo Jones, Kathleen F. Runciman, Kay Nghiem, Son V. TI Increasing solar heating of the Arctic Ocean and adjacent seas, 1979-2005: Attribution and role in the ice-albedo feedback SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID CLIMATE; SUMMER; ALGORITHM AB [1] Over the past few decades the Arctic sea ice cover has decreased in areal extent. This has altered the solar radiation forcing on the Arctic atmosphere-ice-ocean system by decreasing the surface albedo and allowing more solar heating of the upper ocean. This study addresses how the amount of solar energy absorbed in areas of open water in the Arctic Basin has varied spatially and temporally over the past few decades. A synthetic approach was taken, combining satellite-derived ice concentrations, incident irradiances determined from reanalysis products, and field observations of ocean albedo over the Arctic Ocean and the adjacent seas. Results indicate an increase in the solar energy deposited in the upper ocean over the past few decades in 89% of the region studied. The largest increases in total yearly solar heat input, as much as 4% per year, occurred in the Chukchi Sea and adjacent areas. C1 US Army Engn Res & Dev Ctr, Cold Regions Res & Engn Lab, Hanover, NH USA. Polar Sci Ctr, Appl Phys Lab, Seattle, WA USA. Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK USA. CALTECH, Jet Propuls Lab, Pasadena, CA USA. RP Perovich, DK (reprint author), US Army Engn Res & Dev Ctr, Cold Regions Res & Engn Lab, Hanover, NH USA. EM donald.k.perovich@erdc.usace.army.mil RI Eicken, Hajo/M-6901-2016 NR 26 TC 164 Z9 176 U1 3 U2 24 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD OCT 11 PY 2007 VL 34 IS 19 AR L19505 DI 10.1029/2007GL031480 PG 5 WC Geosciences, Multidisciplinary SC Geology GA 221HL UT WOS:000250217900005 ER PT J AU Buda-Okreglak, EM Walden, MJ Brissette, MD AF Buda-Okreglak, Edwarda M. Walden, Michael J. Brissette, Mark D. TI Perineural CNS invasion in primary cutaneous follicular center lymphoma SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID B-CELL LYMPHOMA; PROGNOSTIC-FACTORS; CLASSIFICATION; EXPRESSION; FREQUENCY C1 Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, Washington, DC 20307 USA. RP Buda-Okreglak, EM (reprint author), Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, Washington, DC 20307 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD OCT 10 PY 2007 VL 25 IS 29 BP 4684 EP 4686 DI 10.1200/JCO.2007.12.8397 PG 3 WC Oncology SC Oncology GA 233EQ UT WOS:000251073600030 PM 17925565 ER PT J AU Kitchen, LW Vaughn, DW AF Kitchen, Lynn W. Vaughn, David W. TI Role of US military research programs in the development of US-licensed vaccines for naturally occurring infectious diseases SO VACCINE LA English DT Review DE vaccines; US military; USFDA ID MENINGOCOCCAL POLYSACCHARIDE VACCINE; JAPANESE ENCEPHALITIS VACCINE; GUILLAIN-BARRE-SYNDROME; JANUARY-FEBRUARY 1976; SWINE INFLUENZA-A; UNCOMPLICATED TYPHOID-FEVER; TYPE-4 ADENOVIRUS VACCINES; ACUTE RESPIRATORY DISEASE; ENTERIC-COATED CAPSULES; DIPLOID TISSUE CULTURE AB U.S. military physicians and researchers have collaborated in the development of eight U.S-licensed vaccines since 1934, when product efficacy requirements were added to product safety requirements mandated in 1902. These vaccines include influenza (1945), rubella (1969), adenovirus types 4 and 7 (1980), meningococcus A, C, Y, W-135 (1981), hepatitis B (1981), oral typhoid (1989), Japanese encephalitis (1992), and hepatitis A (1995). Current efforts include new adenovirus and Japanese encephalitis vaccines, and vaccines to prevent dengue, diarrhea due to enterotoxigenic E coli, Campylobacter, and Shigella, malaria, hemorrhagic fever with renal syndrome, scrub typhus, meningococcus type B, and HIV infection. All vaccines currently administered to U.S. military forces must be licensed by the U.S. Food and Drug Administration (FDA). Published by Elsevier Ltd. C1 US Army Med Res & Mat Command, Mil Infect Dis Res Program, Ft Detrick, MD 21702 USA. RP Kitchen, LW (reprint author), US Army Med Res & Mat Command, Mil Infect Dis Res Program, Ft Detrick, MD 21702 USA. EM Lynn.Kitchen@us.army.mil NR 118 TC 19 Z9 19 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 10 PY 2007 VL 25 IS 41 BP 7017 EP 7030 DI 10.1016/j.vaccine.2007.07.030 PG 14 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 224NY UT WOS:000250454900003 PM 17728025 ER PT J AU Jiang, G Charoenvit, Y Moreno, A Baraceros, MF Banania, G Richie, N Abot, S Ganeshan, H Fallarme, V Patterson, NB Geall, A Weiss, WR Strobert, E Caro-Aquilar, I Lanar, DE Saul, A Martin, LB Gowda, K Morrissette, CR Kaslow, DC Carucci, DJ Galinski, MR Doolan, DL AF Jiang, George Charoenvit, Yupin Moreno, Alberto Baraceros, Maria F. Banania, Glenna Richie, Nancy Abot, Steve Ganeshan, Harini Fallarme, Victoria Patterson, Noelle B. Geall, Andrew Weiss, Walter R. Strobert, Elizabeth Caro-Aquilar, Ivette Lanar, David E. Saul, Allan Martin, Laura B. Gowda, Kalpana Morrissette, Craig R. Kaslow, David C. Carucci, Daniel J. Galinski, Mary R. Doolan, Denise L. TI Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization SO MALARIA JOURNAL LA English DT Article ID MALARIA VACCINE DEVELOPMENT; APICAL MEMBRANE ANTIGEN-1; NONIONIC BLOCK-COPOLYMER; CYTOTOXIC T-LYMPHOCYTES; GENE-BASED VACCINES; PROTECTIVE IMMUNITY; PLASMID DNA; CIRCUMSPOROZOITE PROTEIN; ANTIBODY-RESPONSES; NONHUMAN-PRIMATES AB The present study has evaluated the immunogenicity of single or multiple Plasmodium falciparum (Pf) antigens administered in a DNA prime/poxvirus boost regimen with or without the poloxamer CRLI005 in rhesus monkeys. Animals were primed with PfCSP plasmid DNA or a mixture of PfCSP, PfSSP2/TRAP, PfLSAI, PfAMAI and PfMSPI-42 (CSLAM) DNA vaccines in PBS or formulated with CRLI005, and subsequently boosted with ALVAC-Pf7, a canarypox virus expressing the CSLAM antigens. Cell-mediated immune responses were evaluated by IFN-gamma ELIspot and intracellular cytokine staining, using recombinant proteins and overlapping synthetic peptides. Antigen- specific and parasite-specific antibody responses were evaluated by ELISA and IFAT, respectively. Immune responses to all components of the multi-antigen mixture were demonstrated following immunization with either DNA/PBS or DNA/CRL1005, and no antigen interference was observed in animals receiving CSLAM as compared to PfCSP alone. These data support the down-selection of the CSLAM antigen combination. CRLI005 formulation had no apparent effect on vaccine-induced T cell or antibody responses, either before or after viral boost. In high responder monkeys, CD4+IL-2+ responses were more predominant than CD8+ T cell responses. Furthermore, CD8+ IFN-responses were detected only in the presence of detectable CD4+ T cell responses. Overall, this study demonstrates the potential for multivalent Pf vaccines based on rational antigen selection and combination, and suggests that further formulation development to increase the immunogenicity of DNA encoded antigens is warranted. C1 [Jiang, George; Charoenvit, Yupin; Baraceros, Maria F.; Banania, Glenna; Richie, Nancy; Abot, Steve; Ganeshan, Harini; Fallarme, Victoria; Patterson, Noelle B.; Geall, Andrew; Weiss, Walter R.; Gowda, Kalpana; Carucci, Daniel J.; Doolan, Denise L.] Naval Med Res Ctr, Malaria Program, Silver Spring, MD 20910 USA. [Jiang, George; Baraceros, Maria F.; Banania, Glenna; Richie, Nancy; Abot, Steve; Ganeshan, Harini; Fallarme, Victoria; Patterson, Noelle B.] Henry M Jackson Fdn, Rockville, MD 20852 USA. [Moreno, Alberto; Galinski, Mary R.] Emory Univ, Yerkes Natl Primate Res Ctr, Emory Vaccine Ctr, Atlanta, GA 30329 USA. [Moreno, Alberto; Strobert, Elizabeth; Caro-Aquilar, Ivette; Galinski, Mary R.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30329 USA. [Geall, Andrew; Kaslow, David C.] Vical Inc, San Diego, CA 92121 USA. [Lanar, David E.; Morrissette, Craig R.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Saul, Allan; Martin, Laura B.] NIAID, Malaria Vaccine Dev Branch, NIH, Rockville, MD 20852 USA. [Doolan, Denise L.] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. [Doolan, Denise L.] Bancroft Ctr, Queensland Inst Med Res, Brisbane, Qld 4029, Australia. RP Doolan, DL (reprint author), Naval Med Res Ctr, Malaria Program, Silver Spring, MD 20910 USA. EM jiang_george@bah.com; charoenvity@nmrc.navy.mil; amoreno@rmy.emory.edu; sjs1973maria@yahoo.com; bananiag@nmrc.navy.mil; Nancy.Richie@amedd.army.mil; abots@nmrc.navy.mil; ganeshanh@nmrc.navy.mil; fallarmev@nmrc.navy.mil; pattersonn@nmrc.navy.mil; andrew.geall@novartis.com; weissw@nmrc.navy.mil; estrobert@rmy.emory.edu; icaroaquilar@rmy.emory.edu; david.lanar@us.army.mil; asaul@niaid.nih.gov; lmartin@niaid.nih.gov; gowdak@nmrc.navy.mil; craig.morrissette@us.army.mil; David_Kaslow@merck.com; dcarucci@fnih.org; Galinski@rmy.emory.edu; Denise.Doolan@qimr.edu.au RI Lanar, David/B-3560-2011; Saul, Allan/I-6968-2013; Martin, Laura/N-1789-2013; Doolan, Denise/F-1969-2015 OI Saul, Allan/0000-0003-0665-4091; Martin, Laura/0000-0002-4431-4381; NR 81 TC 21 Z9 22 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD OCT 9 PY 2007 VL 6 AR 135 DI 10.1186/1475-2875-6-135 PG 17 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 243SN UT WOS:000251817700001 PM 17925026 ER PT J AU Semenov, YG Kim, KW Zavada, JM AF Semenov, Y. G. Kim, K. W. Zavada, J. M. TI Spin field effect transistor with a graphene channel SO APPLIED PHYSICS LETTERS LA English DT Article AB A spin field effect transistor (FET) is proposed by utilizing a graphene layer as the channel. Similar to the conventional spin FETs, the device involves spin injection and spin detection by ferromagnetic source and drain. Due to the negligible spin-orbit coupling in the carbon based materials, spin manipulation in the channel is achieved via electrical control of the electron exchange interaction with a ferromagnetic gate dielectric. Numerical estimates indicate the feasibility of the concept if the bias can induce a change in the exchange interaction energy of the order of meV. When nanoribbons are used for a finite channel width, those with armchair-type edges can maintain the device stability against the thermal dispersion. (C) 2007 American Institute of Physics. C1 N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Semenov, YG (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM kwk@ncsu.edu NR 21 TC 102 Z9 104 U1 12 U2 68 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 8 PY 2007 VL 91 IS 15 AR 153105 DI 10.1063/1.2798596 PG 3 WC Physics, Applied SC Physics GA 220EW UT WOS:000250140700050 ER PT J AU Nghiem, SV Rigor, IG Perovich, DK Clemente-Colon, P Weatherly, JW Neumann, G AF Nghiem, S. V. Rigor, I. G. Perovich, D. K. Clemente-Colon, P. Weatherly, J. W. Neumann, G. TI Rapid reduction of Arctic perennial sea ice SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID EXTENT; VARIABILITY; OSCILLATION AB [1] The extent of Arctic perennial sea ice, the year-round ice cover, was significantly reduced between March 2005 and March 2007 by 1.08 X 10(6) km(2), a 23% loss from 4.69 X 10(6) km(2) to 3.61 X 10(6) km(2), as observed by the QuikSCAT/ SeaWinds satellite scatterometer ( QSCAT). Moreover, the buoy-based Drift-Age Model (DM) provided long-term trends in Arctic sea-ice age since the 1950s. Perennial-ice extent loss in March within the DM domain was noticeable after the 1960s, and the loss became more rapid in the 2000s when QSCAT observations were available to verify the model results. QSCAT data also revealed mechanisms contributing to the perennial-ice extent loss: ice compression toward the western Arctic, ice loading into the Transpolar Drift (TD) together with an acceleration of the TD carrying excessive ice out of Fram Strait, and ice export to Baffin Bay. Dynamic and thermodynamic effects appear to be combining to expedite the loss of perennial sea ice. C1 CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA. Univ Washington, Polar Sci Ctr, Appl Phys Lab, Seattle, WA 98195 USA. Cold Reg Res & Engn Lab, Hanover, NH USA. Natl Ice Ctr, Suitland, MA USA. RP Nghiem, SV (reprint author), CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA. EM Son.V.Nghiem@jpl.nasa RI Clemente-Colon, Pablo/F-5581-2010 NR 20 TC 200 Z9 213 U1 4 U2 38 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD OCT 4 PY 2007 VL 34 IS 19 AR L19504 DI 10.1029/2007GL031138 PG 6 WC Geosciences, Multidisciplinary SC Geology GA 218VZ UT WOS:000250045400002 ER PT J AU Hargrave, ML Britt, T Reynolds, MD AF Hargrave, Michael L. Britt, Tad Reynolds, Matthew D. TI Magnetic evidence of ridge constructon and use at poverty point SO AMERICAN ANTIQUITY LA English DT Article ID NORTHEAST LOUISIANA; SITE; ARCHAEOLOGY; EXAMPLE AB A magnetic field gradient survey was conducted at Poverty Point to determine if that technique could detect discrete subsurface features and differentiate the ridges and swales in an area that today exhibits very little topographic relief. The survey area (280 m long by 20 to 60 in wide) crossed Ridges 1 through 5 in the southwest portion of the site. The ridges were revealed as variegated bands of positive and negative magnetic anomalies whereas the swales appeared to be relatively homogeneous. Ridge 1, nearest the plaza, is wider and higher but has less of a flank midden than the other ridges. Two roughly circular arrangements of anomalies on Ridge 1 are potentially important but cannot be reliably interpreted without ground truthing excavations. Future large-area, high-resolution magnetic gradient surveys could dramatically enhance our understanding of this enigmatic site. C1 USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. Tierra Right Way Serv, Tucson, AZ 85718 USA. RP Hargrave, ML (reprint author), USA, Engn Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM Michael.L.Hargrave@erdc.usace.army.mil; John.T.Britt@erdc.usace.army.mil; mreynolds@tierra-row.com NR 49 TC 5 Z9 5 U1 1 U2 7 PU SOC AMER ARCHAEOLOGY PI WASHINGTON PA 900 SECOND ST., NE STE 12, WASHINGTON, DC 20002-3557 USA SN 0002-7316 J9 AM ANTIQUITY JI Am. Antiq. PD OCT PY 2007 VL 72 IS 4 BP 757 EP 769 PG 13 WC Anthropology; Archaeology SC Anthropology; Archaeology GA 227OZ UT WOS:000250668900009 ER PT J AU Xia, Y Bray, DW AF Xia, Yang Bray, David W. TI Pregnancy-related pruritic rash SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Xia, Y (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM yang.xia@na.amedd.army.mil NR 5 TC 2 Z9 2 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD OCT 1 PY 2007 VL 76 IS 7 BP 1019 EP 1020 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 217SG UT WOS:000249967000014 PM 17956074 ER PT J AU Piesman, M Hwang, I Maydonovitch, C Wong, RKH AF Piesman, Michael Hwang, Inku Maydonovitch, Corinne Wong, Roy K. H. TI Nocturnal reflux episodes following the administration of a standardized meal. Does timing matter ? SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID SYMPTOMATIC GASTROESOPHAGEAL-REFLUX; BODY-MASS INDEX; EROSIVE ESOPHAGITIS; RISK-FACTOR; DISEASE; ASSOCIATION; VOLUNTEERS; HEARTBURN; OBESITY; SLEEP AB OBJECTIVES: Prospective evidence supporting lifestyle modifications, including avoidance of late evening meals, for gastroesophageal reflux disease (GERD) sufferers is lacking. The aim of this study was to determine the difference of supine esophageal acid exposure in patients consuming an early or late standard meal relative to bedtime. METHODS: This is a prospective, randomized unblinded crossover trial. Thirty-two patients with typical reflux symptoms were enrolled and randomized to consume a standard meal either at 6 h or 2 h prior to going to bed for 2 consecutive nights. Acid exposure was measured for 48-h using a Bravo wireless pH system. Reflux symptom frequency and severity were recorded. RESULTS: Thirty patients successfully completed the study (63% male, 70% white, mean age 46 [24-74], mean body mass index [BMI] 28 kg/m(2) 18-40]). EGD revealed esophagitis in 37% and hiatal hernia (HH) in 47% of patients. Following the late evening meal, there was significantly more supine reflux (P = 0.002) when compared to the early meal. Significantly more supine reflux was also noted following the late evening meal in patients with HH, in overweight individuals (25 <= BMI <= 29.9), and those reporting heartburn as their chief complaint. Patients with esophagitis had more supine reflux following both the late and early evening meals. There was no significant difference in total symptom score between the 2 days. CONCLUSIONS: GERD patients consuming a late-evening meal had significantly greater supine acid reflux compared to when they consumed an early meal, especially in overweight patients, and in patients with esophagitis or HH. These findings support the recommendations to our GERD patients to eat dinner early and to lose weight. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Wong, RKH (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 28 TC 35 Z9 42 U1 0 U2 3 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2007 VL 102 IS 10 BP 2128 EP 2134 DI 10.1111/j.1572-0241.2007.01348.x PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 215QN UT WOS:000249824200004 PM 17573791 ER PT J AU Harrison, SA AF Harrison, Stephen A. TI Small molecule and novel treatments for chronic hepatitis C virus infection SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID ANTIVIRAL ACTIVITY; HCV INFECTION; PROTEASE; INHIBITOR; PHARMACOKINETICS; REPLICATION; INTERFERON; VIRAMIDINE; RIBAVIRIN; PRODRUG AB The development of molecular-based therapies for the treatment of chronic hepatitis C virus (HCV) infection is an area of intense clinical research, driven by the inability of the current standard of care, combination therapy with pegylated interferon alfa (PEG-IFN alpha) and ribavirin (RBV), to achieve a sustained virologic response (SVR) in a large proportion of patients and by the lack of approved alternative therapies for PEG-IFN alpha/RBV nonresponders and relapsers. Agents being developed against specific HCV viral proteins have recently been termed Specifically Targeted Antiviral Therapy for HCV (STAT-C). Preliminary data for several agents show they have high antiviral activity, especially when used in combination with PEG-IFN alpha, and are tolerable, but resistance mutations have been identified. Further study is needed to clarify the safety, tolerability, and efficacy of these compounds. Once established, the potential for shorter treatment strategies could then be evaluated. Other novel therapies in development that may improve both outcomes and tolerability include a prodrug of RBV and an albumin-modified IFN alpha. In conclusion, small molecule and novel therapies for HCV infection are showing promise in clinical trials, and research to develop new agents and optimize treatment regimens is ongoing. C1 Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Dept Med, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 40 TC 7 Z9 7 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2007 VL 102 IS 10 BP 2332 EP 2338 DI 10.1111/j.1572-0241.2007.01397.x PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 215QN UT WOS:000249824200032 PM 17617208 ER PT J AU Jones, FJ Andrews, AH AF Jones, Frances J. Andrews, Allan H. TI Acute liver injury associated with the herbal supplement hydroxycut in a soldier deployed to Iraq SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Letter ID GREEN TEA C1 Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Jones, FJ (reprint author), Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 5 TC 24 Z9 24 U1 1 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 2007 VL 102 IS 10 BP 2357 EP 2358 DI 10.1111/j.1572-0241.2007.01353_10.x PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 215QN UT WOS:000249824200043 PM 17897352 ER PT J AU Sonek, J AF Sonek, Jiri TI Nasal bone in screening for trisomy 21: defining hypoplasia SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Editorial Material C1 Wright State Univ, Dept Obstet & Gynecol, Dayton, OH 45435 USA. USA, Fetal Med Fdn, Dayton, OH USA. RP Sonek, J (reprint author), Wright State Univ, Dept Obstet & Gynecol, Dayton, OH 45435 USA. NR 7 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD OCT PY 2007 VL 197 IS 4 BP 335 EP 336 DI 10.1016/j.ajog.2007.08.032 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 219PO UT WOS:000250097300001 PM 17904954 ER PT J AU Mountcastle, SB Posner, M Kragh, JF Taylor, DC AF Mountcastle, Sally B. Posner, Matthew Kragh, John F. Taylor, Dean C. TI Gender differences in anterior cruciate ligament injury vary with activity - Epidemiology of anterior cruciate ligament injuries in a young, athletic population SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE ACL; epidemiology; military; gender ID SPORTS; KNEE; WOMEN; BASKETBALL; PLAYERS; SOCCER; RISKS; ARMY; MEN AB [Background: Previous studies have shown that women involved in similar activities as men are at increased risk for anterior cruciate ligament injuries. Hypothesis: The incidence rate of complete anterior cruciate ligament tears for men and women in our athletic, college-aged population is similar. Study Design: Descriptive epidemiology study. Methods: Students graduating in class years 1994 to 2003 at our institution who sustained complete anterior cruciate ligament tears were assessed for mechanism of injury and type of sport played at time of injury. We calculated the incidence proportion, an estimation of risk, by gender and class year, and the incidence proportion ratio comparing men and women by class year. We also calculated incidence rates by gender and type of sport played and incidence rate ratios comparing men and women. Results: There were 353 anterior cruciate ligament injuries in the 10 classes studied. We found an overall, 4-year incidence proportion of 3.24 per 100 (95% confidence interval, 2.89-3.63) for men and 3.51 (95% confidence interval, 2.65-4.65) for women (incidence proportion ratio, 1.09 [95% confidence interval, 0.80-1.47]). The overall anterior cruciate ligament injury rate, excluding male-only sports, was significantly greater in women (incidence rate ratio, 1.51 [95% confidence interval, 1.03-2.21]). We found significantly greater injury rates among women in a gymnastics course (incidence rate ratio, 5.67 [95% confidence interval, 1.99-16.16]), indoor obstacle course test (incidence rate ratio, 3.72 [95% confidence interval, 1.25-11.10]), and basketball (incidence rate ratio, 2.42 [95% confidence interval, 1.05-5.59)). Conclusion: We found little gender difference in the overall risk of an anterior cruciate ligament tear; however, there were gender differences in injury rates when specific sports and activities were compared and when male-only sports were removed from the overall rate assessment. C1 Duke Univ, Med Ctr, Dept Surg, Div Orthopaed Surg, Durham, NC 27710 USA. William Beaumont Army Med Ctr, Keller Army Hosp, Dept Orthopaed Surg, Div Orthopaed Surg, West Point, NY USA. William Beaumont Army Med Ctr, Dept Orthopaed Surg, Ft Billins, TX USA. RP Taylor, DC (reprint author), Duke Univ, Med Ctr, Dept Surg, Div Orthopaed Surg, Box 3615, Durham, NC 27710 USA. EM dean.taylor@duke.edu NR 16 TC 70 Z9 72 U1 1 U2 15 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD OCT PY 2007 VL 35 IS 10 BP 1635 EP 1642 DI 10.1177/0363546507302917 PG 8 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 218XR UT WOS:000250049800004 PM 17519438 ER PT J AU Arora, R Newton, TC Nelson, MR AF Arora, Rajiv Newton, Thomas C. Nelson, Michael R. TI Subcutaneous immunoglobulin therapy in an 11-year-old patient with common variable immunodeficiency and von Willebrand disease SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID PRIMARY ANTIBODY DEFICIENCIES; GAMMA-GLOBULIN; REPLACEMENT; INFUSIONS; HOME; MANAGEMENT; CHILDREN; SAFETY; LIFE AB Background: Subcutaneous immunoglobulin (SCIG) is an option for replacement therapy in patients with humoral immune deficiencies. Objective: To describe a patient with common variable immunodeficiency (CVID) and von Willebrand disease who tolerated immunoglobulin replacement via the subcutaneous route. Methods: An 11-year-old boy receiving monthly intravenous immunoglobulin (IVIG) since 5 years of age presented to an academic medical center after moving to the area. The patient also had a history of von Willebrand disease. He had started receiving IVIG because of recurrent infections and an absent IgG subclass 3. Further immunologic assessment revealed a normal B-cell count, decreased IgM level, and an abnormal response to bacteriophage Phi X174. Given these findings and the lack of another cause, the patient was diagnosed as having CVID. Because of difficult intravenous access, a port was placed for IVIG administration in 1999. The initial port was removed because of infectious complications, and a second port was found to be distally displaced in the right atrium, requiring removal. Results: Continued difficulties with intravenous access and the potential complications with maintaining a long-term indwelling catheter prompted consideration of alternative methods for immunoglobulin administration. After removal of the port, the patient was prescribed weekly SCIG infusions. He tolerated the infusions well without bleeding complications related to the von Willebrand disease and was able to transition to home infusions. Conclusions: SCIG was well tolerated by a pediatric patient with CVID and von Willebrand disease without any significant bleeding complications. C1 Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pediat Hematol Oncol, Washington, DC 20307 USA. RP Arora, R (reprint author), Walter Reed Army Med Ctr, Dept Allergy Immunol, 6900 Georgia Ave, Washington, DC 20307 USA. EM rajiv.arora@us.army.mil NR 14 TC 6 Z9 6 U1 0 U2 1 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD OCT PY 2007 VL 99 IS 4 BP 367 EP 370 PG 4 WC Allergy; Immunology SC Allergy; Immunology GA 220OS UT WOS:000250166600013 PM 17941286 ER PT J AU Harshbarger, RJ AF Harshbarger, Raymond J. TI Invited discussion: The management of maxillofacial trauma in the renaissance - A mini-case series-review SO ANNALS OF PLASTIC SURGERY LA English DT Editorial Material ID RECONSTRUCTION C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Harshbarger, RJ (reprint author), Plast Surg Clin, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM raymond.harshbargerl@na.amedd NR 3 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-7043 J9 ANN PLAS SURG JI Ann. Plast. Surg. PD OCT PY 2007 VL 59 IS 4 BP 375 EP 377 DI 10.1097/SAP.0b013e31812e4ba9 PG 3 WC Surgery SC Surgery GA 213YD UT WOS:000249702300004 PM 17901726 ER PT J AU Ellis, MW Griffith, ME Dooley, DP McLean, JC Jorgensen, JH Patterson, JE Davis, KA Hawley, JS Regules, JA Rivard, RG Gray, PJ Ceremuga, JM DeJoseph, MA Hospenthal, DR AF Ellis, Michael W. Griffith, Matthew E. Dooley, David P. McLean, Joseph C. Jorgensen, James H. Patterson, Jan E. Davis, Kepler A. Hawley, Joshua S. Regules, Jason A. Rivard, Robert G. Gray, Paula J. Ceremuga, Julia M. DeJoseph, Mary A. Hospenthal, Duane R. TI Targeted intranasal mupirocin to prevent colonization and infection by community-associated methicillin-resistant Staphylococcus aureus strains in soldiers: A cluster randomized controlled trial SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID FIELD GEL-ELECTROPHORESIS; PANTON-VALENTINE LEUKOCIDIN; NASAL CARRIAGE; ANTERIOR NARES; HEALTHY-ADULTS; UNITED-STATES; PROPHYLAXIS; EMERGENCE; PREVALENCE; OINTMENT AB Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen that primarily manifests as uncomplicated skin and soft tissue infections. We conducted a cluster randomized, double-blind, placebo-controlled trial to determine whether targeted intranasal mupirocin therapy in CAMRSA-colonized soldiers could prevent infection in the treated individual and prevent new colonization and infection within their study groups. We screened 3,447 soldiers comprising 14 training classes for CA-MRSA colonization from January to December 2005. Each training class was randomized to either the mupirocin or placebo study group, and the participants identified as CA-MRSA colonized were treated with either mupirocin or placebo. All participants underwent repeat screening after 8 to 10 weeks and were monitored for 16 weeks for development of infection. Of 3,447 participants screened, 134 (3.9%) were initially colonized with CAMRSA. Five of 65 (7.7%; 95% confidence interval [95% CI], 4.0% to 11.4%) placebo-treated participants and 7 of 66 (10.6%; 95% CI, 7.9% to 13.3%) mupirocin-treated participants developed infections; the difference in the infection rate of the placebo- and mupirocin -treated groups was -2.9% (95% CI, -7.5% to 1.7%). Of those not initially colonized with CA-MRSA, 63 of 1,459 (4.3%; 95% CI, 2.7% to 5.9%) of the placebo group and 56 of 1,607 (3.5%; 95% CI, 2.6% to 5.2%) of the mupirocin group developed infections; the difference in the infection rate of the placebo and mupirocin groups was 0.8% (95% CI, -1.0% to 2.7%). Of 3,447 participants, 3,066 (89%) were available for the second sampling and completed follow-up. New CA-MRSA colonization occurred in 24 of 1,459 (1.6%; 95% CI, 0.05% to 2.8%) of the placebo group participants and 23 of 1,607 (1.4%; 95% CI, 0.05% to 2.3%) of the mupirocin group participants; the difference in the infection rate of the placebo and mupirocin groups was 0.2% (95% CI, -1.3% to 1.7%). Despite CA-MRSA eradication in colonized participants, this study showed no decrease in infections in either the mupirocin -treated individuals or within their study group. Furthermore, CA-MRSA eradication did not prevent new colonization within the study group. C1 Audie L Murphy Mem Vet Adm Med Ctr, San Antonio, TX USA. DD Eisenhower Army Med Ctr, Dept Med Infect Dis, Ft Gordon, GA USA. Brooke Army Med Ctr, Dept Med Infect Dis, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Prevent Med, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Pathol & Area Lab Serv, Ft Sam Houston, TX 78234 USA. Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX USA. Univ Texas, Hlth Sci Ctr, Dept Med Infect Dis, San Antonio, TX USA. RP Ellis, MW (reprint author), Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, 3581 Roger Brooke, Ft Sam Houston, TX 78234 USA. EM michael.w.ellis@us.army.mil NR 53 TC 79 Z9 81 U1 1 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2007 VL 51 IS 10 BP 3591 EP 3598 DI 10.1128/AAC.01086-06 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 215FX UT WOS:000249794800017 PM 17682105 ER PT J AU Moran, ML Greenfield, RJ Wilson, DK AF Moran, Mark L. Greenfield, Roy J. Wilson, D. Keith TI Acoustic array tracking performance under moderately complex environmental conditions SO APPLIED ACOUSTICS LA English DT Article DE array; direction-of-arrival; beamforming; performance; wavefront distortion; complex environment; array aperture; phase error; topography; acoustic shadow ID SOUND FIELD; TURBULENCE; ATMOSPHERE; COHERENCE; BOUNDS AB The direction-of-arrival (DOA) tracking performance of microphone arrays having aperture sizes ranging from 0.3 to 34 m is examined for an experiment involving a vehicle traversing a moderately complex terrain. A segment of the vehicle's path was obscured behind a small, 6.7-m high, vegetated hill. The combination of the hill and upwind propagation created an acoustic shadow during this segment. DOA tracks were estimated with a minimum-variance distortionless response (MVDR) beamformer operating in two frequency bands: 25-60 Hz and 60-105 Hz. In the lower frequency band, array sizes between 1 and 8 m gave the best results, with DOA errors between 2 degrees and 5 degrees. Furthermore, in this band shadowing from the hill and wind refraction had a minimal affect on DOA error. In the higher frequency band, the acoustic shadow zone produced a distinct interval of high DOA error, with the 8-m array giving the best overall performance. Modeling of the beamforming process shows that high DOA errors corresponded to MVDR wavenumber patterns that are degraded by distortions to the propagating wavefronts. Our experimental results indicate that small acoustic arrays with apertures less than 0.3 m, operating at frequencies above 100 Hz, should be considered line of sight sensors. Given the moderate complexity of the test conditions, it is anticipated that the observed effects are likely to be present in most attempts to localize outdoor sound sources. Published by Elsevier Ltd. C1 US Army Corps Engn, Engn Res & Dev Ctr, Hanover, NH 03755 USA. RP Moran, ML (reprint author), US Army Corps Engn, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM mark.1.moran@erdc.usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 24 TC 11 Z9 14 U1 1 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-682X J9 APPL ACOUST JI Appl. Acoust. PD OCT PY 2007 VL 68 IS 10 BP 1241 EP 1262 DI 10.1016/j.apacoust.2006.08.008 PG 22 WC Acoustics SC Acoustics GA 214RX UT WOS:000249756900011 ER PT J AU Magnes, J Schwarz, G Hartke, J Burt, D Melikechi, N AF Magnes, Jenny Schwarz, Gregory Hartke, John Burt, Derek Melikechi, Noureddine TI Optomechanical integration method for finite integrals SO APPLIED OPTICS LA English DT Article ID KNIFE-EDGE AB We present, for the first time to our knowledge, an optomechanical integration method for finite functions. This technique allows for the integration of any finite function by combining optical and mechanical principals. The integrated function can then be determined using curve fitting methods. Furthermore, the original function can be reproduced through numerical or analytical integration. (c) 2007 Optical Society of America. C1 Vassar Coll, Dept Phys & Astron, New York, NY 12604 USA. US Mil Acad, Dept Phys, West Point, NY 10996 USA. US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. Delaware State Univ, Dept Phys & Preengn, Delaware, OH 19901 USA. Delaware State Univ, Ctr Res & Educ Opt Sci & Applicat, Dover, DE 19901 USA. RP Magnes, J (reprint author), Vassar Coll, Dept Phys & Astron, 124 Raymond Ave, New York, NY 12604 USA. EM jemagnes@vassar.edu NR 17 TC 1 Z9 1 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 1 PY 2007 VL 46 IS 28 BP 6918 EP 6922 DI 10.1364/AO.46.006918 PG 5 WC Optics SC Optics GA 226DA UT WOS:000250566200011 PM 17906719 ER PT J AU Tannenbaum, LV Thran, BH Williams, KJ AF Tannenbaum, Lawrence V. Thran, Brandolyn H. Williams, Keith J. TI Demonstrating ecological receptor health at contaminated sites with wild rodent sperm parameters SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID RISK; MICE AB Consistently at Superfund and other contaminated terrestrial sites, ecological receptors have been chemically exposed for multiple decades by the time risk assessments are conducted. Given that numerous generations of the receptors have lived through the contaminated site condition by the present day, a paradigm shift from risk assessment, where the potential for health effects are forecasted, to a direct, health status assessment scheme for the site-exposed receptor, would seem to be most appropriate. We applied the only such existing direct health status assessment method, Rodent Sperm Analysis (RSA), with small rodents trapped at contaminated sites and at matched noncontaminated reference locations. Reproductive health, ecological risk assessment's endpoint of greatest concern, is targeted with RSA by comparing the sperm parameters of count, motility, and morphology, for each of which it is known how much of a change from a control condition signifies compromised reproductive capability. Given that sperm parameter thresholds were not exceeded in maximally exposed receptors, the data suggest that in the general case, contaminated terrestrial sites do not need cleanups to afford health protection to ecological species, and particularly the larger, wider-ranging, higher trophic level species. Our findings suggest that RSA has the ability to consistently discriminate between clean and contaminated sites, and that the method can allow for as definitive determinations of terrestrial ecological receptor health as are possible, thereby facilitating early site clean-up decisions. C1 US Army Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. North Bay Fdn, North East, MD USA. RP Tannenbaum, LV (reprint author), US Army Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. EM larry.tannenbaum@us.army.mil NR 16 TC 6 Z9 6 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0090-4341 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD OCT PY 2007 VL 53 IS 3 BP 459 EP 465 DI 10.1007/s00244-006-0169-1 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 205RL UT WOS:000249132200020 PM 17612787 ER PT J AU Brietzke, SE Katz, ES Roberson, DW AF Brietzke, Scott E. Katz, Eliot S. Roberson, David W. TI Pulse transit time as a screening test for pediatric steep-related breathing disorders SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article; Proceedings Paper CT 21st Annual Meeting of the American-Society-of-Pediatric-Otolaryngology CY MAY 20-22, 2006 CL Chicago, IL SP Amer Soc Pediat Otolaryngol ID OBSTRUCTIVE SLEEP-APNEA; BLOOD-PRESSURE; APNEA/HYPOPNEA SYNDROME; RESPIRATORY EVENTS; CHILDREN; APNOEA/HYPOPNOEA; HISTORY AB Objectives: To evaluate a noninvasive measure of arousal, the pulse transit time (PTT), as a screening tool for obstructive sleep apnea/hypopnea syndrome (OSAHS) in an unselected population of symptomatic children, compared with overnight polysomnography (PSG). A secondary objective included comparing the diagnostic performance of PTT with continuous pulse oximetry recorded during PSG. Design: Prospective, blinded diagnostic comparison study using the gold standard of overnight PSG. Setting: Tertiary-care children's hospital sleep laboratory. Patients: An unselected, volunteer sample of 59 patients (mean age, 7.8 years) with and without adenotonsillar tissue undergoing PSG and simultaneous PTT, including patients with obesity and cramofacial syndromes. Main Outcome Measures: The relationship between the PTT and polysomnographic measures of OSAHS to include pulse oximetry using correlation coefficients and receiver operating characteristic curve analysis. Results: The correlation coefficient between the PTT arousal index and PSG apnea-hypopnea index (AHI) was 0.70 (P < .001). Linear regression resulted in a good fit (R-2 = 0.73) between PTT arousal index and AHI. With the use of an AHI of 1 or greater (35.6% prevalence of OSAHS) as a criteria for OSAHS, the area under the receiver operating characteristic curve was 0.86 (95% confidence interval, 0.76-0.96). The optimal PTT arousal index threshold was 5.4 events per hour, which translated into a sensitivity of 81% and a specificity of 76%. Conclusions: The PTT arousal index is highly correlated with the PSG-derived AHI and demonstrated excellent diagnostic utility for moderate and severe OSAHS. However, for mild OSAHS, PTT was barely adequate and did not significantly outperform pulse oximetry. Pulse transit time may be a useful tool to evaluate moderate to severe sleep-related breathing disorders in children. C1 Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. Childrens Hosp, Dept Pediat Pulmunol, Boston, MA USA. Childrens Hosp, Dept Otolaryngol, Boston, MA USA. Childrens Hosp, Dept Commun Disorders, Boston, MA USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. EM SEBrietzke@msn.com FU NHLBI NIH HHS [HL 073238] NR 20 TC 24 Z9 26 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD OCT PY 2007 VL 133 IS 10 BP 980 EP 984 DI 10.1001/archotol.133.10.980 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 218XN UT WOS:000250049400003 PM 17938320 ER PT J AU Acevedo, J Wallin, J Vezina, G Shah, RK AF Acevedo, Jason Wallin, Jordan Vezina, Gilbert Shah, Rahul K. TI Radiology quiz case 1 - Sclerosing osteomyelitis of Garre, or sclerosing nonsuppurative osteomyelitis SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material ID PERIOSTITIS OSSIFICANS C1 George Washington Univ, Walter Reed Army Med Ctr, Childrens Natl Med Ctr, Sch Med, Washington, DC 20052 USA. RP Acevedo, J (reprint author), George Washington Univ, Walter Reed Army Med Ctr, Childrens Natl Med Ctr, Sch Med, Washington, DC 20052 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD OCT PY 2007 VL 133 IS 10 BP 1058 EP + DI 10.1001/archotol.133.10.1058 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 218XN UT WOS:000250049400016 PM 17938333 ER PT J AU Kiesling, EEC AF Kiesling, Eugenia E. C. TI Dunkirk: Fight to the Last Man. SO ARMED FORCES & SOCIETY LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Kiesling, EEC (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2007 VL 34 IS 1 BP 151 EP 153 DI 10.1177/0095327X07303703 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA 209TX UT WOS:000249412000010 ER PT J AU DeBerardino, TM Branstetter, JG Owens, BD AF DeBerardino, Thomas M. Branstetter, Joanna G. Owens, Brett D. TI Arthroscopic treatment of unresolved Osgood-Schlatter lesions SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY LA English DT Article DE arthroscopy; Osgood-Schlatter disease; debridement; mobile ossicles; tibial tuberosity ID DISEASE; HISTORY AB Osgood-Schlatter disease is a self-limiting condition in most cases. Those with unresolved pain after conservative treatment can obtain relief with surgical debridement of the mobile ossicles and tibial tuberosity. We present an arthroscopic technique for debridement. The location of the inferomedial and lateral parapatella tendon portals can be raised slightly to allow improved instrumentation and visualization in the anterior interval. An anterior interval release is performed with the mechanical shaver and radiofrequency ablation device. Care is taken to visualize the meniscal anterior horns and intermeniscal ligament. By staying anterior to these structures, debridement can be performed aggressively onto the anterior tibial slope. The bony lesions are shelled out from their soft-tissue attachments. Small and loose fragments are removed with a pituitary ronguer, whereas larger lesions are removed with an arthroscopic burr. Working deep along the anterior tibial slope is facilitated by extending the knee and taking tension off the patellar tendon. Postoperatively, patients are allowed full weight bearing and unrestricted range of motion. The advantages of this technique include the avoidance of the patellar tendon longitudinal split required for open procedures and the ability to address concomitant intra-articular pathology. C1 US Mil Acad, Keller Army Hosp, Orthoped Surg Serv, West Point, NY 10996 USA. RP Owens, BD (reprint author), US Mil Acad, Keller Army Hosp, Orthoped Surg Serv, West Point, NY 10996 USA. EM b.owens@us.anny.mil OI DeBerardino, Thomas/0000-0002-7110-8743 NR 8 TC 1 Z9 1 U1 1 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD OCT PY 2007 VL 23 IS 10 AR 1127.e1 DI 10.1016/j.arthro.2006.12.004 PG 3 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 225DY UT WOS:000250498500016 PM 17916481 ER PT J AU Wesensten, NJ Reichardt, RM Balkin, TJ AF Wesensten, Nancy J. Reichardt, Rebecca M. Balkin, Thomas J. TI Ampakine (CX717) effects on performance and alertness during simulated night shift work SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE vigilance; stimulants; sleep ID SLEEP-DEPRIVATION; MODAFINIL; CAFFEINE; TASK; ENHANCEMENT; TRIAZOLAM AB Introduction: Round-the-clock operations in both military and civilian sectors have increased the need for alertness- and performance-maintaining strategies. The potential performance and objective alertness-enhancing effects of CX717 (a novel cognitive enhancer currently being tested in Phase 11 clinical trials) were evaluated using a simulated night shift work paradigm. Methods: In this randomized, double-blind, placebo-controlled, parallel groups design, 48 volunteers underwent 4 consecutive nights of simulated shift work. Each "shift" consisted of the following: at approximately 2145 (just prior to the start of each simulated night shift), volunteers ingested a single oral dose of CX717 200 mg, CX717 400 mg, CX717 1000 mg, or placebo (N = 12 per drug dosage). Performance, alertness, mood, and symptoms were then assessed from 2300 to 0700, followed by a polysomnographically monitored daytime sleep period from 0800 to 1200. Results: Performance and alertness significantly degraded across the simulated night shifts (P < 0.05). None of the dosages of CX717 reversed these effects (P > 0.05). CX717 exerted some effects on daytime sleep, most notably reduction of slow-wave sleep time (P < 0.05). CX717 caused very few side effects and none of those were serious or unexpected. Discussion and Conclusions: At the doses tested, CX717 was not effective for reversing performance and alertness deficits associated with night shift work. Further work evaluating higher doses of CX717 may be warranted, as are studies in which CX717 effects are explored under other conditions (e.g., Alzheimer's dementia, attention deficit disorder). C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Wesensten, NJ (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM nancy.wesensten@na.amedd.army.mil NR 20 TC 23 Z9 24 U1 2 U2 7 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 2007 VL 78 IS 10 BP 937 EP 943 DI 10.3357/ASEM.2055.2007 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 215UJ UT WOS:000249834200004 PM 17955941 ER PT J AU Killgore, WDS Lipizzi, EL Kamimori, GH Balkin, TJ AF Killgore, William D. S. Lipizzi, Erica L. Kamimori, Gary H. Balkin, Thomas J. TI Caffeine effects on risky decision making after 75 hours of sleep deprivation SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE Iowa Gambling Task; risk-taking; executive function; prefrontal cortex; wakefulness; sleep loss; somatic marker hypothesis ID PSYCHOMOTOR VIGILANCE PERFORMANCE; FUTURE CONSEQUENCES; 24 H; DAMAGE; DECREMENTS; MODAFINIL; ATTENTION; JUDGMENT; DISEASE; BRAIN AB Introduction: Recent research indicates that sleep deprivation impairs decision making. However, it is unknown to what extent such deficits are exacerbated in a dose-response manner by increasing levels of sleepiness, and the extent to which such sleep-loss-induced deficits can be reversed by caffeine. Methods: At three time points, 26 healthy subjects completed alternate forms of the Iowa Gambling Task (IGT): rested baseline, 51 h awake, and 75 h awake. Every 2 h each night, 12 volunteers also received 4 200-mg doses of caffeine, with the last dose occurring 3 h prior to the IGT. Results: At baseline, volunteers readily learned to avoid disadvantageous high-risk card decks while progressively choosing more frequently from advantageous low-risk card decks. When sleep deprived, however, these same subjects showed impaired performance, choosing more frequently from the disadvantageous high-risk card decks, particularly during the latter half of the game. Contrary to expectations, the severity of performance impairment did not increase significantly from 51 to 75 h of wakefulness, and caffeine had no significant effects on IGT performance during sleep deprivation. Discussion and Conclusions: As a provisional extension of our previous study, these preliminary findings further suggest that the ability to integrate emotion with cognition to guide decision making, a capacity believed to be mediated by the ventromedial prefrontal cortex, may be particularly vulnerable to sleep loss. Moreover, these capacities may not be significantly improved by moderate doses of caffeine, suggesting that they may function separately from simple arousal and alertness systems. C1 Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM d.killgore@us.army.mil OI Killgore, William/0000-0002-5328-0208 NR 41 TC 43 Z9 45 U1 1 U2 7 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 2007 VL 78 IS 10 BP 957 EP 962 DI 10.3357/ASEM.2106.2007 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 215UJ UT WOS:000249834200007 PM 17955944 ER PT J AU Postman-Caucheteux, WA Hoffman, S Picchiom, D McArdle, J Birn, R Braun, A AF Postman-Caucheteux, W. A. Hoffman, S. Picchiom, D. McArdle, J. Birn, R. Braun, A. TI Distinct activation patterns for accurate vs. inaccurate naming of actions and objects: An fMRI study with stroke patients with chronic aphasia SO BRAIN AND LANGUAGE LA English DT Meeting Abstract C1 [Postman-Caucheteux, W. A.; Hoffman, S.; McArdle, J.; Braun, A.] Natl Inst Deafness & Commun Disorders, NIH, Bethesda, MD 20892 USA. [Picchiom, D.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. [Birn, R.] NIMH, NIH, Bethesda, MD 20892 USA. EM postmanw@nided.nih.gov NR 6 TC 1 Z9 1 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0093-934X J9 BRAIN LANG JI Brain Lang. PD OCT-NOV PY 2007 VL 103 IS 1-2 BP 150 EP 151 DI 10.1016/j.bandl.2007.07.090 PG 2 WC Audiology & Speech-Language Pathology; Linguistics; Neurosciences; Psychology, Experimental SC Audiology & Speech-Language Pathology; Linguistics; Neurosciences & Neurology; Psychology GA 227MF UT WOS:000250660100072 ER PT J AU Parekh, DJ Ankerst, DP Baillargeon, J Higgins, B Platz, EA Troyer, D Hernandez, J Leach, RJ Lokshin, A Thompson, IM AF Parekh, Dipen J. Ankerst, Donna Pauler Baillargeon, Jacques Higgins, Betsy Platz, Elizabeth A. Troyer, Dean Hernandez, Javier Leach, Robin J. Lokshin, Anna Thompson, Ian M. TI Assessment of 54 biomarkers for biopsy-detectable prostate cancer SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID PREOPERATIVE PLASMA-LEVELS; PREVENTION TRIAL; OVARIAN-CANCER; GROWTH-FACTORS; EXPRESSION; PROGRESSION; RISK; METALLOPROTEINASES; ASSOCIATION; METASTASIS AB Objective: We analyzed the association of 54 biomarkers from seven classes including adipokines, immune response metalloproteinases, adhesion molecules, and growth factors with prostate cancer risk adjusting for the Prostate Cancer Prevention Trial (PCPT) risk score. Methods: A total of 123 incident prostate cancer cases and 127 age-matched controls were selected from subjects in the San Antonio Center for Biomarkers of Risk of Prostate Cancer cohort study. Prediagnostic serum concentrations were measured in the sample collected at baseline using LabMAP technology. The odds ratios (OR) of prostate cancer risk associated with serum concentrations of 54 markers were estimated using univariate conditional logistic regression before and after adjustment for the PCPT risk score. Two-way hierarchical unsupervised clustering techniques were used to evaluate whether the 54-marker panel distinguished cases from controls. Results: Vascular endothelial growth factor, resistin, interleukin 1Ra (IL-1Ra), granulocyte colony-stimulating factor, matrix metalloproteinase-3, plasminogen activator inhibitor, and kallikrein-8 were statistically significantly (P < 0.05) underexpressed in prostate cancer cases, and alpha-fetoprotein was statistically significantly overexpressed in prostate cancer cases, but all had area underneath the receiver-operating characteristic curve <60%; none were statistically significant adjusting for multiple comparisons (P < 0.0008) or after adjustment for the PCPT risk score. Statistical clustering of patients by the marker panel did not distinguish a separate group of cases from controls. Conclusions: This age-matched case-control study did not support findings of increased diagnostic potential from a 54-marker panel when compared with the conventional risk factors incorporated in the PCPT risk calculator. Future discovery of new biomarkers should always be tested and compared against conventional risk factors before applying them in clinical practice. C1 Univ Texas, Hlth Sci Ctr, Dept Urol, San Antonio, TX 78284 USA. Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78284 USA. Univ Texas, Hlth Sci Ctr, Dept Cell & Struct Biol, San Antonio, TX 78284 USA. Brooke Army Med Ctr, San Antonio, TX USA. Univ Texas, Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX 77550 USA. Johns Hopkins Bloomberg, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. Univ Pittsburgh Canc Ctr, Pittsburgh, PA USA. RP Parekh, DJ (reprint author), Univ Texas, Hlth Sci Ctr, Dept Urol, 7703 Floyd Curl Dr, San Antonio, TX 78284 USA. EM parekhd@uthscsa.edu FU NCI NIH HHS [U01CA086402] NR 23 TC 14 Z9 15 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD OCT PY 2007 VL 16 IS 10 BP 1966 EP 1972 DI 10.1158/1055-9965.EPI-07-0302 PG 7 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 222HC UT WOS:000250285900009 PM 17932343 ER PT J AU Allegrini, P Grigolini, P AF Allegrini, P. Grigolini, P. TI Dedicated to Professor Radu Balescu In search of a theory of complexity - Preface SO CHAOS SOLITONS & FRACTALS LA English DT Editorial Material ID RANDOM-WALKS; DYNAMICS C1 Duke Univ, Dept Phys, Durham, NC 27708 USA. Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. Univ Pisa, Dipartimento Fis E Fermi, I-56127 Pisa, Italy. CNR, Ist Proc Chim Fis, I-56124 Pisa, Italy. RP Allegrini, P (reprint author), Duke Univ, Dept Phys, Durham, NC 27708 USA. EM allegrip@df.unipi.it RI Allegrini, Paolo/C-1876-2012 OI Allegrini, Paolo/0000-0002-5476-9005 NR 5 TC 1 Z9 1 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-0779 J9 CHAOS SOLITON FRACT JI Chaos Solitons Fractals PD OCT PY 2007 VL 34 IS 1 BP 1 EP 2 DI 10.1016/j.chaos.2007.01.043 PG 2 WC Mathematics, Interdisciplinary Applications; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA 171RI UT WOS:000246752700001 ER PT J AU Grigolini, P Allegrini, P West, BJ AF Grigolini, Paolo Allegrini, Paolo West, Bruce J. TI In search of a theory of complexity: An overview on the Denton workshop SO CHAOS SOLITONS & FRACTALS LA English DT Article; Proceedings Paper CT Denton Workshop on In Search of a Theory of Complexity held in Honor of Radu Balescu CY AUG, 2005 CL Denton, TX ID BLINKING QUANTUM DOTS; 1/F NOISE; INTERMITTENCY; SEQUENCES; SPECTRUM; ENTROPY; MODEL AB This paper is an outgrowth of the discussions held during the 2005 Denton Workshop, In Search of a Theory of Complexity. The workshop title captures the intent of the scientists who had come from Europe, the middle east and the United States to discuss the possibility that recent advances in statistical physics might provide a perspective that could guide us in constructing a theory of complexity. In this first paper of the proceedings we attempt to summarize the concepts introduced in the various debates and to draw some conclusions. But we caution the reader that these conclusions are our own and are not necessarily shared by the other participants of the workshop. (c) 2007 Elsevier Ltd. All rights reserved. C1 Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. Duke Univ, Dept Phys, Durham, NC 27708 USA. Univ Pisa, Dipartimento Fis, I-56127 Pisa, Italy. CNR, IPFC, I-56124 Pisa, Italy. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Grigolini, P (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. EM grigo@unt.edu RI Allegrini, Paolo/C-1876-2012 OI Allegrini, Paolo/0000-0002-5476-9005 NR 30 TC 3 Z9 3 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-0779 EI 1873-2887 J9 CHAOS SOLITON FRACT JI Chaos Solitons Fractals PD OCT PY 2007 VL 34 IS 1 BP 3 EP 10 DI 10.1016/j.chaos.2007.01.044 PG 8 WC Mathematics, Interdisciplinary Applications; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA 171RI UT WOS:000246752700002 ER PT J AU Qasim, M Kholod, Y Gorb, L Magers, D Honea, P Leszczynski, J AF Qasim, Mohammad Kholod, Yana Gorb, Leonid Magers, David Honea, Patricia Leszczynski, Jerzy TI Application of quantum-chemical approximations to environmental problems: Prediction of physical and chemical properties of TNT and related species SO CHEMOSPHERE LA English DT Article DE COSMO-RS; density functional theory; ecologically important properties; trinitrotoluene ID COSMO-RS; AQUEOUS SOLUBILITY; SCREENING MODEL; REAL SOLVENTS; 2,4,6-TRINITROTOLUENE; DENSITY; ENERGY; WATER; SOIL; THERMOCHEMISTRY AB This paper presents accurate predictions of ecologically important properties of nitroaromatic compounds and their derivatives, including vapor pressure, Henry's law constants, water solubility, octanol/water partition coefficients, heats of formation and ionization potentials. The proposed technique of calculations was based on quantum-chemical methods. The relationship between the chemical structure and mentioned physico-chemical parameters of such widespread military produced contaminants as trinitrotoluene and its derivatives was considered. We revealed that the DFT level of theory combined with the COSMO-RS technique is able to predict the studied parameters with an accuracy that results in error bars of less then one logarithmic unit. (C) 2007 Elsevier Ltd. All rights reserved. C1 Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. USA, Erdc, Vicksburg, MS 39180 USA. Mississippi Coll, Dept Chem & Biochem, Clinton, MS 39058 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, POB 17910,1325 Lynch St, Jackson, MS 39217 USA. EM jerzy@ccmsi.us NR 40 TC 14 Z9 14 U1 2 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD OCT PY 2007 VL 69 IS 7 BP 1144 EP 1150 DI 10.1016/j.chemosphere.2007.03.067 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 229CL UT WOS:000250778800018 PM 17512030 ER PT J AU Sterner, JB Sill, JM Morris, MJ AF Sterner, James B. Sill, Joshua M. Morris, Michael J. TI Diagnostic evaluation of abnormal inspiratory flow volume loops SO CHEST LA English DT Meeting Abstract CT CHEST 2007 Conference CY OCT 20-25, 2007 CL Chicago, IL SP Amer Coll Chest Phys C1 [Sterner, James B.; Sill, Joshua M.; Morris, Michael J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2007 VL 132 IS 4 SU S BP 485S EP 485S PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 222FY UT WOS:000250282700209 ER PT J AU Bell, DG AF Bell, David G. TI Severe lung injury following exposure to chlorine gas: A case series SO CHEST LA English DT Meeting Abstract CT CHEST 2007 Conference CY OCT 20-25, 2007 CL Chicago, IL SP Amer Coll Chest Phys C1 Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 2 Z9 2 U1 1 U2 3 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2007 VL 132 IS 4 SU S BP 566S EP 566S PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 222FY UT WOS:000250282700488 ER PT J AU Watson, MA Holley, AB King, CS Greenburg, D Parker, J AF Watson, Maura A. Holley, Aaron B. King, Christopher S. Greenburg, David Parker, Joseph TI Association of spirometric and clinical variables with vocal cord dysfunction SO CHEST LA English DT Meeting Abstract CT CHEST 2007 Conference CY OCT 20-25, 2007 CL Chicago, IL SP Amer Coll Chest Phys C1 [Watson, Maura A.; Holley, Aaron B.; King, Christopher S.; Greenburg, David; Parker, Joseph] Walter Reed Army Med Ctr, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2007 VL 132 IS 4 SU S BP 612S EP 612S PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 222FY UT WOS:000250282700651 ER PT J AU Shah, A Holley, AB Moores, LK AF Shah, Anita Holley, Aaron B. Moores, Lisa K. TI Pulmonary embolism risk stratification by non-radiologists using measurements on CT angiogram SO CHEST LA English DT Meeting Abstract CT CHEST 2007 Conference CY OCT 20-25, 2007 CL Chicago, IL SP Amer Coll Chest Phys C1 [Shah, Anita; Holley, Aaron B.; Moores, Lisa K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2007 VL 132 IS 4 SU S BP 627S EP 628S PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 222FY UT WOS:000250282700706 ER PT J AU Collen, J Shorr, AF Moores, LK AF Collen, Jacob Shorr, Andrew F. Moores, Lisa K. TI Prevention of venous thromboembolism in neurosurgery: A systematic review SO CHEST LA English DT Meeting Abstract CT CHEST 2007 Conference CY OCT 20-25, 2007 CL Chicago, IL SP Amer Coll Chest Phys C1 [Collen, Jacob; Shorr, Andrew F.; Moores, Lisa K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2007 VL 132 IS 4 SU S BP 630S EP 630S PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 222FY UT WOS:000250282700714 ER PT J AU King, CS Holley, AB AF King, Christopher S. Holley, Aaron B. TI Severe bullous lung disease and multiple pulmonary nodules SO CHEST LA English DT Meeting Abstract CT CHEST 2007 Conference CY OCT 20-25, 2007 CL Chicago, IL SP Amer Coll Chest Phys ID LYMPHOMA C1 [King, Christopher S.; Holley, Aaron B.] Walter Reed Army Med Ctr, Washington, DC USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2007 VL 132 IS 4 SU S BP 669S EP 670S PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 222FY UT WOS:000250282700849 ER PT J AU Shah, A Osborn, EC Browning, R AF Shah, Anita Osborn, Erik C. Browning, Robert TI Use of intermittent heliox in intubated asthmatics: Are we there yet? SO CHEST LA English DT Meeting Abstract CT CHEST 2007 Conference CY OCT 20-25, 2007 CL Chicago, IL SP Amer Coll Chest Phys ID OXYGEN MIXTURES C1 [Shah, Anita; Osborn, Erik C.; Browning, Robert] Walter Reed Army Med Ctr, Washington, DC USA. NR 2 TC 0 Z9 0 U1 1 U2 2 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2007 VL 132 IS 4 SU S BP 693S EP 694S PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 222FY UT WOS:000250282700901 ER PT J AU Shah, A Osborn, EC Browning, R AF Shah, Anita Osborn, Erik C. Browning, Robert TI Longest reported use of independent lung ventilation in a patient with multifactorial respiratory failure SO CHEST LA English DT Meeting Abstract CT CHEST 2007 Conference CY OCT 20-25, 2007 CL Chicago, IL SP Amer Coll Chest Phys C1 [Shah, Anita; Osborn, Erik C.; Browning, Robert] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2007 VL 132 IS 4 SU S BP 693S EP 693S PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 222FY UT WOS:000250282700900 ER PT J AU Willis, SL Welch, TS Scally, JP Bartoszek, MW Sullenberger, LE Pamplin, JC Hnatiuk, OW AF Willis, Scott L. Welch, Tinrothy S. Scally, John P. Bartoszek, Michael W. Sullenberger, Lance E. Pamplin, Jeremy C. Hnatiuk, Oleh W. TI Impending paradoxical embolism presenting as a pulmonary embolism, transint ischemic attack, and myocardial infarction SO CHEST LA English DT Article DE anticoagulation; pulmonary embolism; thrombosis ID PATENT FORAMEN OVALE AB A 25-year-old man presented with complaints of nonpleuritic, substernal chest pain, dyspnea, and decreasing exercise tolerance. His vital signs were normal, with the exception of an oxygen saturation level of 93% while breathing room air. During his assessment, he developed transient left facial droop, left arm and leg weakness, and an ataxic gait, which lasted 15 min then resolved spontaneously. Cardiac enzyme levels were elevated, and an ECG revealed T-wave inversion in leads 111, aVF, V1, and V2 with evolving ST-segment elevation in leads V3 through V5. The findings of a CT scan and MRI of the head were negative; a Doppler ultrasound of the right lower extremity revealed a thrombus extending from the common femoral vein to the popliteal vein. Cardiac catheterization revealed no evidence of epicardial coronary artery disease. CT pulmonary angiography revealed bilateral pulmonary emboli. Transesophageal echocardiography (TEE) showed a 4-cm, dumbbell-shaped mass lodged in a patent foramen ovale, confirming the diagnosis of an impending paradoxical embolism. The patient was started on therapy with unfractionated heparin, and his thrombus resolved spontaneously by hospital day 5. An impending paradoxical embolism is rare but should be suspected in anyone presenting with evidence of both venous and arterial emboli. The therapeutic options include anticoagulation, thrombolysis, and surgical embolectomy. We would propose that initial treatment with anticoagulation therapy and following with serial TEEs may be appropriate therapy in an otherwise stable patient, with surgical embolectomy or thrombolysis reserved for the treatment of thrombi that do not resolve with anticoagulation therapy or for patients with clinical deterioration. C1 Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Pulm & Crit Care Serv, Washington, DC 20307 USA. RP Willis, SL (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. EM scott.willis2@na.amedd.army.mil NR 4 TC 9 Z9 9 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD OCT PY 2007 VL 132 IS 4 BP 1358 EP 1360 DI 10.1378/chest.07-0100 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 221UY UT WOS:000250254000039 PM 17934122 ER PT J AU Okoye, FI Krishnan, S Chandok, MR George, CT Farber, DL AF Okoye, Francesca I. Krishnan, Sandeep Chandok, Meena R. George, C. Tsokos Farber, Donna L. TI Proximal signaling control of human effector CD4 T cell function SO CLINICAL IMMUNOLOGY LA English DT Article DE signal transduction; tyrosine kinase; T cell differentiation; Cytokines; T cell receptor ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; TCR-ZETA-CHAIN; RECEPTOR-GAMMA-CHAIN; SPLICED 3'-UNTRANSLATED REGION; EPSILON-RI-GAMMA; DOWN-REGULATION; EXPRESSION; ANTIGEN; DIFFERENTIATION; INTERLEUKIN-2 AB The functional coupling of T cell receptor (TCR)-mediated signaling events in primary human T cells remains undefined. We demonstrate here that alterations in the expression of proximal TCR-coupted signaling subunits are associated with distinct effector capacities in differentiated human CD4 T cells. Analysis of proximal signaling profiles using biochemical and single cell approaches reveals decreased 03 and ZAP-70 expression correlating with functional anergy, with increased CD3 zeta/ ZAP-70 expression and phosphorylation connoting acquisition of effector capacity. By contrast, the FcR gamma signaling subunit known to be expressed in human effector cells and in T cells from the autoimmune disease SLE is up-regutated upon activation, yet does not correlate with functional capacity in effector cells, and does not alter signaling or function in primary FcR gamma transfectants. Our results have implications for targeting signaling molecules in immunotherapy and evaluating the functional consequence of signaling alterations associated with autoimmunity and chronic diseases. (c) 2007 Elsevier Inc. All rights reserved. C1 Univ Maryland, Sch Med, Dept Surg, Div Transplantat, Baltimore, MD 21201 USA. Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA. RP Farber, DL (reprint author), Univ Maryland, Sch Med, Dept Surg, Div Transplantat, MSTF Bldg,Room 400,685 W Baltimore St, Baltimore, MD 21201 USA. EM dfarber@smail.umaryland.edu FU NIAID NIH HHS [R01 AI042092, F31 AI058924, R01 AI042092-07, R01 AI042092-09, R01 AI042092-10, R01 AI042269, R29 AI042092, R01 AI042092-08, R01 AI042092-06A1, AI42092, AI042269] NR 32 TC 6 Z9 6 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD OCT PY 2007 VL 125 IS 1 BP 5 EP 15 DI 10.1016/j.clim.2007.07.002 PG 11 WC Immunology SC Immunology GA 212XH UT WOS:000249629800002 PM 17692570 ER PT J AU Mazurek, GH Zajdowicz, MJ Hankinson, AL Costigan, DJ Toney, SR Rothel, JS Daniels, LJ Pascual, FB Shang, N Keep, LW LoBue, PA AF Mazurek, Gerald H. Zajdowicz, Margan J. Hankinson, Arlene L. Costigan, Daniel J. Toney, Sean R. Rothel, James S. Daniels, Laura J. Pascual, F. Brian Shang, Nong Keep, Lisa W. LoBue, Philip A. TI Detection of Mycobacterium tuberculosis infection in united states navy recruits using the tuberculin skin test or whole-blood interferon-gamma release assays SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID T-CELL RESPONSES; CALMETTE-GUERIN VACCINATION; FILTRATE PROTEIN 10; ACTIVE TUBERCULOSIS; ANTIGENS ESAT-6; CLOSED ENVIRONMENT; DIAGNOSIS; OUTBREAK; DISEASE; CFP-10 AB Background. Military personnel are at risk for acquiring Mycobacterium tuberculosis infection because of activities in close quarters and in regions with a high prevalence of tuberculosis (TB). Accurate tests are needed to avoid unnecessary treatment because of false-positive results and to avoid TB because of false-negative results and failure to diagnose and treat M. tuberculosis infection. We sought to estimate the specificity of the tuberculin skin test (TST) and 2 whole-blood interferon-gamma release assays (QuantiFERON-TB assay [QFT] and QuantiFERON-TB Gold assay [QFT-G]) and to identify factors associated with test discordance. Methods. A cross-sectional comparison study was performed in which 856 US Navy recruits were tested for M. tuberculosis infection using the TST, QFT, and QFT-G. Results. Among the study subjects, 5.1% of TSTs resulted in an induration >= 10 mm, and 2.9% of TSTs resulted in an induration >= 15 mm. Eleven percent of QFT results and 0.6% of QFT-G results were positive. Assuming recruits at low risk for M. tuberculosis exposure were not infected, estimates of TST specificity were 99.1% ( 95% confidence interval [CI], 98.3%-99.9%) when a 15-mm cutoff value was used and 98.4% ( 95% CI, 97.3%-99.4%) when a 10-mm cutoff value was used. The estimated QFT specificity was 92.3% ( 95% CI, 90.0%-94.5%), and the estimated QFT-G specificity was 99.8% ( 95% CI, 99.5%-100%). Recruits who were born in countries with a high prevalence of TB were 26-40 times more likely to have discordant results involving a positive TST result and a negative QFT-G result than were recruits born in countries with a low prevalence of TB. Nineteen (50%) of 38 recruits with this type of discordant results had a TST induration >= 15 mm. Conclusions. The QFT-G and TST are more specific than the QFT. No statistically significant difference in specificity between the QFT-G and TST was found using a 15-mm induration cutoff value. The discordant results observed among recruits with increased risk of M. tuberculosis infection may have been because of lower TST specificity or lower QFT- G sensitivity. Negative QFT- G results for recruits born in countries where TB is highly prevalent and whose TST induration was >= 15 mm suggest that the QFT- G may be less sensitive than the TST. Additional studies are needed to determine the risk of TB when TST and QFT- G results are discordant. C1 Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. Emory Univ, Sch Med, Dept Med, Div Pulm & Crit Care, Atlanta, GA USA. Naval Hosp Great Lakes, Great Lakes, IL USA. Walter Reed Army Inst Res, Silver Spring, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Mazurek, GH (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, MS E10,1600 Clifton Rd, Atlanta, GA 30333 USA. EM gym6@cdc.gov NR 42 TC 51 Z9 52 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 1 PY 2007 VL 45 IS 7 BP 826 EP 836 DI 10.1086/521106 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 207FV UT WOS:000249237900002 PM 17806046 ER PT J AU Ergut, A Levendis, YA Richter, H Howard, JB Carlson, J AF Ergut, Ali Levendis, Yiannis A. Richter, Henning Howard, Jack B. Carlson, Joel TI The effect of equivalence ratio on the soot onset chemistry in one-dimensional, atmospheric-pressure, premixed ethylbenzene flames SO COMBUSTION AND FLAME LA English DT Article DE equivalence ratio; PAH; ethylbenzene; premixed flames; soot onset ID POLYCYCLIC AROMATIC-HYDROCARBONS; MUNICIPAL WASTE PLASTICS; PARTICULATE-EMISSIONS; DIFFUSION FLAMES; MOLECULAR-STRUCTURE; 2-STAGE COMBUSTION; POLYMERS PLASTICS; BENZENE FLAMES; TEMPERATURE; POLYSTYRENE AB An investigation was conducted on the evolution of products of incomplete combustion (PIC) emitted from one-dimensional, laminar, atmospheric-pressure ethylbenzene flames in the vicinity of the soot onset threshold. The objective of this study was to identify the role of the fuel-to-air equivalence ratio in the evolution of polycyclic aromatic hydrocarbons (PAH) and other PIC as soot precursors, just prior to and subsequent to soot onset in premixed flames. Liquid ethylbenzene was prevaporized in nitrogen and blended with an oxygen-nitrogen mixture. Upon ignition, premixed flat flames were stabilized over a burner at atmospheric pressure. Temperature measurements and product sampling were conducted at various heights above the burner. Collected samples were analyzed for soot, PAH, oxygenated species, fixed gases, and light hydrocarbons. Three flames were investigated in the vicinity of the observed soot onset threshold, at equivalence ratios of phi(1) = 1.68, phi(2) = 1.74, and phi(3) = 1.83. By adjusting the amounts of oxygen, nitrogen, and fuel, both the maximum measured flame temperature and the spatial profile of the temperature were kept nearly constant as the equivalence ratio was varied. The cold gas velocity through the burner was also kept nearly constant. Changes in species concentration profiles prior to, at and beyond the sooting limit were evaluated. The results indicated that the soot onset limit is not a function of flame temperature alone; i.e., while the maximum measured flame temperatures was kept fairly constant, the flame could be either sooting, at the sooting limit or nonsooting depending on the equivalence ratio. A detailed chemical kinetic model, previously tested against sooting premixed benzene and ethylbenzene flames, was used to gain insight in chemical processes involved in soot formation. A reaction flux analysis was conducted to determine the pathways for ethylbenzene consumption, as well as for benzene and naphthalene formation. Examination of experimental measurements of species along the axis of the flame, in view of the theoretical predictions, showed a rather direct correlation of acetylene to soot formation. Moreover, a correlation between the consumption of ethylbenzene pyrolyzates, such as styrene, and soot formation at the soot onset was also apparent. Whereas the model's results were very encouraging, additional development is deemed necessary to improve its predictive capability in the challenging regime of soot inception. (c) 2007 The Combustion Institute. Published by Elsevier Inc. All rights reserved. C1 Northeastern Univ, Mech & Ind Engn, Boston, MA 02115 USA. MIT, Cambridge, MA 02139 USA. USA, SBCCOM Nat Soldier Ctr, Natick, MA 01760 USA. RP Levendis, YA (reprint author), Northeastern Univ, Mech & Ind Engn, Boston, MA 02115 USA. EM y.levendis@neu.edu NR 65 TC 28 Z9 29 U1 0 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD OCT PY 2007 VL 151 IS 1-2 BP 173 EP 195 DI 10.1016/j.combustflame.2007.04.009 PG 23 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 213AY UT WOS:000249639500013 ER PT J AU Boudali, LK AF Boudali, Lianne Kennedy TI Religious violence in Indonesia SO COMPARATIVE POLITICAL STUDIES LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Boudali, LK (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0010-4140 J9 COMP POLIT STUD JI Comp. Polit. Stud. PD OCT PY 2007 VL 40 IS 10 BP 1263 EP 1266 DI 10.1177/0010414007305068 PG 4 WC Political Science SC Government & Law GA 213WH UT WOS:000249697500005 ER PT J AU Schmidt, DP Shaw, BA Sikora, E Shaw, WW Laliberte, LH AF Schmidt, D. P. Shaw, B. A. Sikora, E. Shaw, W. W. Laliberte, L. H. TI Comparison of testing techniques used to analyze the corrosion resistance of sacrificial coating systems SO CORROSION LA English DT Article DE cabinet tests; constant immersion; electrochemical impedance spectroscopy; galvanized steel; marine atmospheric exposure; organic topcoats; sacrificial coatings; thermal spray ID ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; ATMOSPHERIC CORROSION; ORGANIC COATINGS; PROTECTION ASSESSMENT; COATED STEELS; PART II; ZINC; ALUMINUM; EIS; PERFORMANCE AB The present investigation assessed the corrosion performance of 14 different Zn and At sacrificial coating system configurations based on several different accelerated corrosion testing techniques. The coatings systems tested, which incorporated conversion coating layers, primers, and topcoats, were exposed in a marine atmosphere, two different accelerated cabinet tests (SAE J2334 and ASTM B1 17), and a constant immersion exposure to artificial seawater. Visual observations and electrochemical measurements (including electrochemical impedance spectroscopy [EIS]) were made as a function of exposure time. Me results of these tests were used to compare the corrosion protection abilities of the coating systems based on barrier protection and defect protection. Impedance results were found to be useful for assessing barrier protection while scribe damage allowed for defect protection comparisons. In addition, the testing techniques were compared to correlate results and provide an overall ranking of corrosion protection performance for each coating system. C1 USA, ARDEC, Army Corros Off, Picatinny Arsenal, NJ 07806 USA. Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA. Concurrent Technologies Corp, Largo, FL USA. RP Schmidt, DP (reprint author), USA, ARDEC, Army Corros Off, Picatinny Arsenal, NJ 07806 USA. EM daniel.p.schmidt@us.army.mil NR 54 TC 3 Z9 3 U1 4 U2 13 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0010-9312 J9 CORROSION JI Corrosion PD OCT PY 2007 VL 63 IS 10 BP 958 EP 974 PG 17 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 220MY UT WOS:000250162000007 ER PT J AU Paul, AY Aldrich, S Scott, RS Ellis, MW AF Paul, Amy Y. Aldrich, Shelley Scott, Rolf Sjuve Ellis, Michael W. TI Disseminated histoplasmosis in a patient with AIDS: Case report and review of the literature SO CUTIS LA English DT Article ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CUTANEOUS HISTOPLASMOSIS AB Disseminated histoplasmosis was uncommon prior to the AIDS epidemic, and cutaneous eruption rarely was seen. Since the onset of the worldwide AIDS epidemic, histoplasmosis has become a more common opportunistic fungal infection and should be considered in the differential diagnosis of mucocutaneous lesions in patients with AIDS in endemic areas. We report a case of classic disseminated histoplasmosis in a patient with AIDS and discuss the epidemiology, clinical presentation, pathogenesis, laboratory and histopathologic findings, and treatment options for disseminated histoplasmosis. C1 Evans Army Community Hosp, Dept Dermatol, Ft Carson, CO 80913 USA. Travis AFB, Fairfield, CA USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX 78285 USA. Brooke Army Med Ctr, San Antonio, TX USA. RP Paul, AY (reprint author), Evans Army Community Hosp, Dept Dermatol, Ft Carson, CO 80913 USA. EM amy.paul@amedd.army.mil NR 10 TC 5 Z9 5 U1 0 U2 1 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD OCT PY 2007 VL 80 IS 4 BP 309 EP 312 PG 4 WC Dermatology SC Dermatology GA 223VS UT WOS:000250401200011 PM 18038693 ER PT J AU Amemiya, K Meyers, JL DeShazer, D Riggins, RN Halasohoris, S England, M Ribot, W Norris, SL Waag, DM AF Amemiya, Kei Meyers, Jennifer L. DeShazer, David Riggins, Renaldo N. Halasohoris, Stephanie England, Marilyn Ribot, Wilson Norris, Sarah L. Waag, David M. TI Detection of the host immune response to Burkholderia mallei heat-shock proteins GroEL and DnaK in a glanders patient and infected mice SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article; Proceedings Paper CT Scientific Conference on Chemical and Biological Defense Research CY OCT 14-16, 2005 CL Timonium, MD DE Burkholderia mallei; heat shock proteins; host response ID T-CELLS; HISTOPLASMA-CAPSULATUM; LEGIONELLA-PNEUMOPHILA; PROTECTIVE IMMUNITY; HSP60; PSEUDOMALLEI; SURFACE; HEAT-SHOCK-PROTEIN-60; IDENTIFICATION; LOCALIZATION AB We examined, by enzyme-linked immunosorbent assay and Western blot analysis, the host immune response to 2 heat-shock proteins (hsps) in a patient and mice previously infected with Burkholderia mallei. The patient was the first reported human glanders case in 50 years in the United States. The expression of the groEL and dnaK operons appeared to be dependent upon a sigma(32) RNA polymerase as suggested by conserved heat-shock promoter sequences, and the groESL operon may be negatively regulated by a controlling invert repeat of chaperone expression (CIRCE) site. In the antisera, the GroEL protein was found to be more immunoreactive than the DnaK protein in both a human patient and mice previously infected with B. mallei. Examination of the supernatant of a growing culture of B. mallei showed that more GroEL protein than DnaK protein was released from the cell. This may occur similarly within an infected host causing an elevated host immune response to the B. mallei hsps. Published by Elsevier Inc. C1 USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. RP Amemiya, K (reprint author), USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. EM kei.amemiya@det.amedd.army.mil NR 42 TC 11 Z9 11 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD OCT PY 2007 VL 59 IS 2 BP 137 EP 147 DI 10.1016/j.diagmicrobio.2007.04.017 PG 11 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 220OX UT WOS:000250167100005 PM 17908615 ER PT J AU Fincher, RK Myers, J McNear, S Liveringhouse, JD Topolski, RL McNear, J AF Fincher, R. Keith Myers, Jonathan McNear, Scott Liveringhouse, John D. Topolski, Richard L. McNear, Jennifer TI Comfort and efficacy of a longer and thinner endoscope for average risk colon cancer screening SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article; Proceedings Paper CT Army Regional Meeting of the American-College-of-Physicians CY NOV 11-13, 2004 CL Crystal City, VA SP Amer Coll Physicians DE sigmoidoscopy; comfort; screening; endoscopy ID COLORECTAL-CANCER; FLEXIBLE SIGMOIDOSCOPY; PEDIATRIC COLONOSCOPE; ISSUES; EXTENT; WOMEN AB The aim of this prospective study was to assess patient comfort during nonsedated screening sigmoidoscopy with the use of a standard 60-cm sigmoidoscope compared with a thinner 100-cm upper endoscope. Patients undergoing routine colon cancer screening with sigmoidoscopy were randomly assigned to either a 60-cm sigmoidoscope or a 100-cm upper endoscope. The procedure time, depth of insertion, anatomic landmarks, and presence of polyps were documented. Likert 7-point scales and visual analog scales ( VAS) were performed to measure comfort and symptoms immediately after the procedure and again in 1 week. These scales, procedure time, insertion depth, percent reaching transverse colon, and percent with polyps were analyzed. Eighty-one patients were enrolled with 38 in the 100-cm group and 43 in the 60-cm group. Patients in the 100-cm group reported greater comfort on the VAS compared with the 60-cm group (P = .035) as well as less cramping on the initial Likert scale (P = .017). One week later, the 100-cm group reported higher comfort (P = .015) and less bloating (P = .040). Procedure time was longer for the 100-cm group (8.8 versus 5.9 minutes; P = .001). Insertion depth was 74 versus 56 cm (P = .001), and percent reaching splenic flexure was 76% versus 35% (P = .001) in the 100 and 60 cm groups, respectively. More adenomas were found with the 100-cm scope (P = .035). The use of a thinner and longer endoscope is more comfortable than a standard sigmoidoscope. Although a 100-cm endoscope procedure takes longer to perform, it allows better evaluation of the colon and misses fewer adenomas. C1 DD Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. Med Coll Georgia, Augusta, GA 30912 USA. Gastroenterol Clin, Ft Sam Houston, TX 78234 USA. CentraCare Hlth Ctr, St Cloud, MN 56303 USA. Augusta State Univ, Dept Psychol, Augusta, GA 30904 USA. RP Fincher, RK (reprint author), DD Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. NR 22 TC 2 Z9 2 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD OCT PY 2007 VL 52 IS 10 BP 2892 EP 2896 DI 10.1007/s10620-006-9642-y PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 208DN UT WOS:000249300100066 PM 17394073 ER PT J AU Rosen, G Lotufo, GR AF Rosen, Gunther Lotufo, Guilherme R. TI Toxicity of explosive compounds to the marine mussel, Mytilus galloprovincialis, in aqueous exposures SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE explosives; acute toxicity; embryo-larval development; critical body residue; bivalve; mytilus galloprovincialis ID HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; 2,4,6-TRINITROTOLUENE TNT; DEGRADATION-PRODUCTS; CRASSOSTREA-GIGAS; FATHEAD MINNOW; EDULIS; FATE; SEDIMENT; TRINITROTOLUENE; HYDROCARBONS AB Lethal and sublethal effects of the explosive compounds, 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) were assessed in separate water only exposures to the Mediterranean mussel (Mytilus galloprovincialis). Toxicity endpoints included survival and byssal thread formation in adults, and larval development success of embryos, in 96- and 48-h exposures, respectively. The larval development endpoint was over an order of magnitude more sensitive to TNT compared to adult survival, with median effective concentration (EC50) values of 0.75 and 19.5 mg L-1 (3.30 and 74.1 tmol L-1), respectively. Byssal thread formation (48 h EC50 = 6.57 mg L-1; 29.3 mu mol L-1) was also impaired at sublethal concentrations. The highest RDX and HMX concentrations tested (28.4 and 1.9mgL(-1) [124 and 6.43 mu mol L-1], respectively) failed to promote any significant toxicological effect in exposed mussels. Median lethal residues (LR50) of 14.0 mu g g(-1) (51.0 nmol g(-1)) ww for TNT in the adults were similar to those measured for other marine invertebrates in previous studies, while body residues as high as 19.6 and 0.92 mu g g(86 and 3.1 nmol g(-1)) ww were not associated with any toxicity for RDX and HMX, respectively. Published by Elsevier Inc. C1 Environm Sci & Appl Syst Branch, Space & Naval Warfare Syst Ctr, San Diego, CA 92152 USA. USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Rosen, G (reprint author), Environm Sci & Appl Syst Branch, Space & Naval Warfare Syst Ctr, 53475 Strothe Rd, San Diego, CA 92152 USA. EM gunther.rosen@navy.mil NR 55 TC 15 Z9 15 U1 1 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD OCT PY 2007 VL 68 IS 2 BP 228 EP 236 DI 10.1016/j.ecoenv.2007.03.006 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 222TV UT WOS:000250321100002 PM 17475328 ER PT J AU Rosen, G Lotufo, GR AF Rosen, Gunther Lotufo, Guilherme R. TI Bioaccumulation of explosive compounds in the marine mussel, Mytilus galloprovincialis SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE explosives; toxicokinetics; bioconcentration factor; bivalve; Mytilus galloprovincialis ID CATFISH ICTALURUS-PUNCTATUS; PARTITION-COEFFICIENT; ORGANIC CONTAMINANTS; HYALELLA-AZTECA; 2,4,6-TRINITROTOLUENE; TOXICITY; EDULIS; SEDIMENT; FATE; TOXICOKINETICS AB The bioaccumulative potential of the explosive compounds, 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) were assessed in water only exposures with the Mediterranean mussel (Mytilus galloprovincialis). Toxicokinetics experiments provided uptake rates, elimination rates, biological half-lives, and bioconcentration factors (BCFs). Kinetic BCFs were 1.61, 0.87, and 0.44, for TNT, RDX, and HMX, respectively, and confirmed the expected low bioaccumulative potential of these weakly hydrophobic compounds based on logK(ow). Because apparent steady-state conditions were observed within the 4h uptake period, steady-state BCFs were also calculated, and were within 20% of kinetic BCFs. TNT was rapidly biotransformed to aminodinitrotoluenes within minutes, while no transformation products were measured for RDX or HMX Uptake clearance rates varied among the compounds, while elimination rates and associated half-lives were extremely fast (0. 15-0.49 h). It is unlikely, based on these data, that exposure conditions for these explosive compounds in the marine environment pose unacceptable risks to mussels, and it appears that potential for trophic transfer is quite low. Published by Elsevier Inc. C1 Environm Sci & Appl Syst Branch, Space & Naval Warfare Syst Ctr, San Diego, CA 92152 USA. USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Rosen, G (reprint author), Environm Sci & Appl Syst Branch, Space & Naval Warfare Syst Ctr, 53475 Strothe Rd,Code 2375, San Diego, CA 92152 USA. EM gunther.rosen@navy.mil NR 47 TC 16 Z9 16 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD OCT PY 2007 VL 68 IS 2 BP 237 EP 245 DI 10.1016/j.ecoenv.2007.03.009 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 222TV UT WOS:000250321100003 PM 17629944 ER PT J AU Quinn, MJ Bazar, MA McFarland, CA Perkins, EJ Gust, KA Gogal, RM Johnson, MS AF Quinn, Michael J., Jr. Bazar, Matthew A. McFarland, Craig A. Perkins, Edward J. Gust, Kurt A. Gogal, Robert M., Jr. Johnson, Mark S. TI Effects of subchronic exposure to 2,6-dinitrotoluene in the northern bobwhite (Colinus virginianus) SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE dinitrotoluene; explosives; birds; gavage ID SGOT ACTIVITY; TOXICITY; SERUM AB Explosives and their breakdown products are commonly found in soils at U.S. military instal lations. Many areas where these compounds are found represent useful habitat for ground-foraging birds. Because these birds likely are exposed to such compounds, we evaluated the oral toxicity of 2,6-dinitrotoluene (DNT) in a representative ground-foraging species of management concern. Adult male and female northern bobwhite (Colinus virginianus) were exposed to either 0, 5. 10. 40, or 60 mg/kg/d via gavage for 60 d (subehronic) following determination of the median acute lethal dose (320 mg/kg), Circulating levels of red blood cells and hemoglobin were significantly decreased in a dose-dependent manner: however, levels remained within normal ranges, Plasma concentrations of total protein, albumin, globulin, aspartate aminotransferase, and potassium, sodium, and chlorine ions were significantly decreased, and circulating levels of uric acid were significantly increased, Decreased body weight, enlarged gallbladders. edematous gastrointestinal tracts, pale kidneys. pale and fibrous livers, and loose stools were consistent observations. The effects found in the clinical chemistries taken together with histopathological abnormalities observed in sections of hepatic and renal tissue suggest that the liver and kidneys are major targets for 2,6-DNT Oral exposures to 2,6-DNT appear to affect northern bobwhite in a manner similar to that of the other main DNT isomer. 2,4-DNT, but in more subtle ways, adversely affecting the gastrointestinal system and leading to diarrhea and, ultimately, emaciation. The lowest-observed-adverse-effect level is 40 mg/ kg/d based on hematological measures, and the no-observed-adverse-effect level is 10 mg/kg/d based on the absence of results indicative of adverse effects. C1 USA, Army Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, Aberdeen Proving Ground, MD 21010 USA. USA, Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA. RP Quinn, MJ (reprint author), USA, Army Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, Aberdeen Proving Ground, MD 21010 USA. EM michael.james.quinn@us.army.mil NR 17 TC 9 Z9 9 U1 0 U2 0 PU SOC ENVIRONMENTAL TOXICOLOGY & CHEMISTRY-SETAC PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 2007 VL 26 IS 10 BP 2202 EP 2207 DI 10.1897/07-123R.1 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 211MN UT WOS:000249528000024 PM 17867889 ER PT J AU Johnson, MS Wickwire, WT Quinn, MJ Ziolkowski, DJ Burmistrov, D Menzie, CA Geraghty, C Minnich, M Parsons, PJ AF Johnson, Mark S. Wickwire, Ward Theodore Quinn, Michael J., Jr. Ziolkowski, David J., Jr. Burmistrov, Dima Menzie, Charles A. Geraghty, Ciaran Minnich, Michael Parsons, Patrick J. TI Are songbirds at risk from lead at small arms ranges? An application of the spatially explicit exposure model SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE lead; small arms ranges; spatial analysis; birds; soil ingestion ID DALENE RIVER-BASIN; ECOLOGICAL RISK; CONTAMINATED SEDIMENT; SHOOTING-RANGE; TISSUE-LEVELS; BLOOD LEAD; FEATHERS; MALLARDS; BIRDS; SHOT AB Use of small arms during training is an important activity associated with the development and proficiency of soldiers. These weapons traditionally have used copper-jacketed lead projectiles; the copper facilitates the oxidation of the metallic lead resulting in more mobile oxides and carbonates. Consequently, many ranges at installations have high soil concentrations of lead. Many of these ranges are no longer used and have become habitat for wildlife. To address the potential for adverse effects from lead exposure in songbirds, we compared the outputs of traditional deterministic exposure models with a spatial model and compared the results of both with blood-lead levels from songbird species at two small arms range complexes. An integrative data collection procedure was used and incorporated into the spatially explicit exposure model (SEEM) for two small arms range sites. Site-specific data were used to refine model input parameters. These data included lead soil concentrations, analysis of lead concentrations in nestling food items, acid-insoluble ash content of feces (to estimate soil ingestion), location and mapping of singing males, and nest site location and characteristics. Territorial males also were spot-mapped to determine likelihood of breeding activity. Modeled estimates of risk were compared with blood and feather lead levels of adults and nestlings. Overall, edge species had higher blood-lead concentrations; however, most had concentrations below subclinical effect levels. Conventional deterministic methods produced risk estimates exceeding 10-fold the highest SEEM estimates. The spatially explicit exposure model provided good agreement with field observations and therefore produced more accurate risk estimates. The present study provides support for the application of spatial methods over conventional deterministic methods. C1 USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, Aberdeen Proving Ground, MD 21010 USA. Menzie Cura Assoc, Winchester, MA 01824 USA. New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA. RP Johnson, MS (reprint author), USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, Aberdeen Proving Ground, MD 21010 USA. EM mark.s.johnson@us.army.mil OI Ziolkowski Jr., David/0000-0002-2500-4417; Parsons, Patrick/0000-0001-9133-875X NR 67 TC 9 Z9 12 U1 1 U2 6 PU SOC ENVIRONMENTAL TOXICOLOGY & CHEMISTRY-SETAC PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD OCT PY 2007 VL 26 IS 10 BP 2215 EP 2225 DI 10.1897/07-068R.1 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 211MN UT WOS:000249528000026 PM 17867887 ER PT J AU Fabricius, M Fuhr, S Willumsen, L Strong, A Bhatia, R Boutelle, M Dreier, J Hartings, J Bullock, R Lauritzen, M AF Fabricius, Martin Fuhr, S. Willumsen, L. Strong, A. Bhatia, R. Boutelle, M. Dreier, J. Hartings, J. Bullock, R. Lauritzen, M. TI Cortical spreading depression and seizures co-occur after acute brain injury SO EPILEPSIA LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Epilepsy-Society CY NOV 13-DEC 04, 2007 CL Philadelphia, PA SP Amer Epilepsy Soc C1 [Fabricius, Martin; Fuhr, S.; Lauritzen, M.] Glostrup Cty Hosp, Dept Clin Neurophysiol, Glostrup, Denmark. [Fuhr, S.; Dreier, J.] Univ Med Berlin, Charite, Dept Expt Neurol, Berlin, Germany. [Willumsen, L.] Glostrup Cty Hosp, Dept Neurosurg, Glostrup, Denmark. [Strong, A.; Bhatia, R.] Kings Coll London, Dept Clin Neurosci, London WC2R 2LS, England. [Boutelle, M.] Univ London Imperial Coll Sci & Technol, Dept Bioengn, London, England. [Hartings, J.] Walter Reed Army Inst Res, Bethesda, MD USA. [Bullock, R.] Virginia Commonwealth Univ Med Coll Virginia, Div Neurosurg, Richmond, VA USA. RI Boutelle, Martyn/C-6051-2008 NR 0 TC 0 Z9 0 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0013-9580 J9 EPILEPSIA JI Epilepsia PD OCT PY 2007 VL 48 SU 6 BP 249 EP 249 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA 259CY UT WOS:000252917900670 ER PT J AU Johannes, B Wittels, P Enne, R Eisinger, G Castro, CA Thomas, JL Adler, AB Gerzer, R AF Johannes, Bernd Wittels, Peter Enne, Robert Eisinger, Guenter Castro, Carl A. Thomas, Jeffrey L. Adler, Amy B. Gerzer, Rupert TI Non-linear function model of voice pitch dependency on physical and mental load SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE modeling voice pitch dynamics; heart rate; blood pressure; physical versus mental load ID EMOTIONAL-STRESS; FUNDAMENTAL-FREQUENCY; INDICATORS AB The present work describes that under increasing physical load the voice fundamental frequency (voice pitch) remains on a given level as long as the physical load is well tolerated by the subject, whereas heart rate and blood pressure continuously increase during increasing physical load. This voice pitch level was compared to voice pitch levels under mental load. Using a word recognition system, 11 well trained, young male subjects had to solve 2 moderate mental load tasks. Before, during and after each task, there were structured relaxation phases. The physical load protocol was a standard bicycle stress test. In each protocol phase the subjects had to count from 1 to 10 in order to provide a standardized speech sample. Heart rate and blood pressure were recorded in all phases. Voice frequency was at average 106 +/- 5.2 Hz in the relaxation phases ('rest level') and was increased under mental load (115.9 +/- 5.7 Hz, Pillais-P = 0.037). During physical stress testing, voice pitch remained unchanged ('tolerated load level') between 100 and 200 W (117.4 +/- 4.8 Hz) and increased shortly before physical exhaustion ('Cyexhaustion level', 275-350 W, 142.9 +/- 5.6 Hz, Pillais-P = 0.007). In contrast, heart rate and blood pressure increased continuously with the physical load. Three voice pitch levels could be verified also individually for each subject. For the practical monitoring of emotional stress the individual anchor frequencies for these levels must be assessed. These data indicate that the relationship between both types of load and voice pitch is non-linear with multiple plateaus and transition functions between them. C1 German Aerosp Ctr DLR, Div Aerosp Phychol, Inst Aerosp Med, D-22335 Hamburg, Germany. Forschungsgruppe Leistungsmed Heeresspital, A-1210 Vienna, Austria. Walter Reed Army Inst Res, Div Neuropsychiat, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, US Army Med Res Unit Europe, D-69126 Heidelberg, Germany. German Aerosp Ctr DLR, Inst Aerosp Med, D-51147 Cologne, Germany. RP Johannes, B (reprint author), German Aerosp Ctr DLR, Div Aerosp Phychol, Inst Aerosp Med, Sportallee 54a, D-22335 Hamburg, Germany. EM bernd.johannes@dlr.de; rupert.gerzer@dlr.de NR 26 TC 15 Z9 15 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD OCT PY 2007 VL 101 IS 3 BP 267 EP 276 DI 10.1007/s00421-007-0496-6 PG 10 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 208DX UT WOS:000249301100001 PM 17554549 ER PT J AU Shorr, AF Wainright, JL Cors, CS Lettieri, CJ Nathan, SD AF Shorr, A. F. Wainright, J. L. Cors, C. S. Lettieri, C. J. Nathan, S. D. TI Pulmonary hypertension in patients with pulmonary fibrosis awaiting lung transplant SO EUROPEAN RESPIRATORY JOURNAL LA English DT Article DE epidemiology; haemodynamics; idiopathic pulmonary fibrosis; pulmonary hypertension ID SURVIVAL; DISEASE; SARCOIDOSIS AB Pulmonary hypertension (PH) may complicate idiopathic pulmonary fibrosis (IPF) but the prevalence of PH in iPF remains undefined. The present authors sought to describe the prevalence of PH in IPF. The lung transplant registry for the USA (January 1995 to June 2004) was analysed and IPF patients who had undergone right heart catheterisation (RHC) were identified. PH was defined as a mean pulmonary arterial pressure (Ppa) >25 mmHg and severe PH as a Ppa >40 mmHg. Independent factors associated with PH were determined. Of the 3,457 persons listed, 2,525 (73.0%) had undergone RHC. PH affected 46.1% of subjects; -9% had severe PH. Variables independently associated with mild-to-moderate PH were as follows: need for oxygen, pulmonary capillary wedge pressure (P_pcw) and forced expiratory volume in one second (FEV1). Independent factors related to severe PH included the following: carbon dioxide tension, age, FEV1, P_pcw, need for oxygen and ethnicity. A sensitivity analysis in subjects with P_pcw <15 mmHg did not appreciably alter the present findings. Pulmonary hypertension is common in idiopathic pulmonary fibrosis patients awaiting lung transplant, but the elevations in mean pulmonary arterial pressure are moderate. Lung volumes alone do not explain the pulmonary hypertension. Given the prevalence of pulmonary hypertension and its relationship with surrogate markers for quality of life (e.g. activities of daily living), future trials of therapies for this may be warranted. C1 Washington Hosp Ctr, Pulm & Crit Care Med Sect, Washington, DC 20010 USA. Walter Reed Army Med Ctr, Dept Pulm & Crit Care Med, Washington, DC 20307 USA. Fairfax Inova Hosp, INOVA Transplant Ctr, Falls Church, VA USA. RP Shorr, AF (reprint author), Washington Hosp Ctr, Pulm & Crit Care Med Sect, Room 2A-38D,110 Irving St,NW, Washington, DC 20010 USA. EM afshorr@dnamail.com NR 17 TC 128 Z9 134 U1 0 U2 1 PU EUROPEAN RESPIRATORY SOC JOURNALS LTD PI SHEFFIELD PA 146 WEST ST, STE 2.4, HUTTONS BLDG, SHEFFIELD S1 4ES, ENGLAND SN 0903-1936 J9 EUR RESPIR J JI Eur. Resp. J. PD OCT PY 2007 VL 30 IS 4 BP 715 EP 721 DI 10.1183/09031936.00107206 PG 7 WC Respiratory System SC Respiratory System GA 220CV UT WOS:000250135400018 PM 17626111 ER PT J AU Chatterjee, S Neill, R Shupp, JW Hammamieh, R Ionin, B Jett, M AF Chatterjee, Subroto Neill, Roger Shupp, Jeffrey W. Hammamieh, Rasha Ionin, Boris Jett, Marti TI Identification of staphylococcal enterotoxin B domains involved in binding to cultured human kidney proximal tubular cells: Imparting proliferation and death SO EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article DE enterotoxin; SEB; renal proximal tubule cells; sphingolipids ID FAMILIAL HYPERCHOLESTEROLEMIA; IN-VITRO; GLYCOSPHINGOLIPIDS; LOCALIZATION; SUPERANTIGEN; HYDROLYSIS; RECEPTOR; TOXIN; VIVO AB Studies suggest that staphylococcal enterotoxin B (SEB) is initially harbored in the kidney by binding to digalactosylceramide molecules in the proximal tubular cells. However, little is known in regard to the peptide motif within SEB that binds to these cells and imparts toxic effects. Herein, using human kidney proximal tubular cells (PTs) we have performed a systematic study on the binding of various peptides and peptide analogs of SEB and demonstrate a structure-functional relationship. Using [1251]labeled SEB peptides, we show a high affinity and displaceable binding of SEB 191-220 to human PT cells. Binding was mitigated by the use of antibody against SEB, by digalactosylceramide (the putative receptor), and by the use of endoglycoceramidase, which selectively removes the oligosaccharide backbones from glycosphingolipids. Our structure/ functional studies revealed that peptide 130-160 induces a concentration-dependent increase in programmed cell death/ apoptosis in human proximal tubular cells. Mechanistic studies further suggest that SEB/SEB peptide (130-160) impart apoptosis via the activation of neutral sphingomyelinase, which hydrolizes sphingomyelin to ceramide and phosphocholine. SEB 130-160 mediated apoptosis was mitigated by preincubation of cells with antibody against SEB and an SEB 130-160 antibody. C1 Johns Hopkins Univ, Dept Pediat, Baltimore, MD 21205 USA. Walter Reed Army Inst Res, Dept Mol Pathol, Div Pathol, Silver Spring, MD 20910 USA. RP Chatterjee, S (reprint author), Johns Hopkins Univ, Dept Pediat, 550 N Broadway,Suite 312, Baltimore, MD 21205 USA. EM schatte2@jhmi.edu NR 27 TC 1 Z9 1 U1 0 U2 2 PU SOC EXPERIMENTAL BIOLOGY MEDICINE PI MAYWOOD PA 195 WEST SPRING VALLEY AVE, MAYWOOD, NJ 07607-1727 USA SN 1535-3702 J9 EXP BIOL MED JI Exp. Biol. Med. PD OCT PY 2007 VL 232 IS 9 BP 1140 EP 1151 DI 10.3181/0609-RM-245 PG 12 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 216OL UT WOS:000249887500003 ER PT J AU Sharpe, WN Pulskamp, J Gianola, DS Eberl, C Polcawich, RG Thompson, RJ AF Sharpe, W. N., Jr. Pulskamp, J. Gianola, D. S. Eberl, C. Polcawich, R. G. Thompson, R. J. TI Strain measurements of silicon dioxide microspecimens by digital imaging processing SO EXPERIMENTAL MECHANICS LA English DT Article DE thin films; tensile testing; strain measurement; Young's modulus; silicon dioxide; fracture strength ID THIN-FILMS; MECHANICAL-PROPERTIES; FRACTURE STRENGTH; TENSILE-STRENGTH; YOUNGS MODULUS; SPECIMEN SIZE; POLYSILICON; TESTS; MEMS AB Silicon dioxide thin film is a common component in electronic devices and in MEMS, but its mechanical properties have rarely been studied. Techniques have been adapted and developed to conduct tensile tests on 1.0 mu m thick silicon dioxide specimens that are 100, 150, and 200 mu m wide and either 1 or 2 mm long. One end of the specimen remains fastened to the substrate, and the other is glued to a silicon carbide fiber attached to a 30 g load cell mounted on a piezoelectric translation stage. Strain is measured by digital imaging of two gold lines applied to the gage section of the transparent specimen. Twenty-five tests yield a Young's modulus of 60.1 +/- 3.4 GPa and a fracture strength of 364 +/- 57 MPa. C1 Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. USA, Res Lab, Sensors & Elect Dev Directorate, Adelphi, MD 20783 USA. RP Sharpe, WN (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. EM sharpe@jhu.edu RI Eberl, Christoph/F-3175-2010 OI Eberl, Christoph/0000-0003-4271-1380 NR 30 TC 63 Z9 65 U1 0 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD OCT PY 2007 VL 47 IS 5 BP 649 EP 658 DI 10.1007/s11340-006-9010-z PG 10 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA 212VC UT WOS:000249623900007 ER PT J AU Song, B Ge, Y Chen, WW Weerasooriya, T AF Song, B. Ge, Y. Chen, W. W. Weerasooriya, T. TI adial inertia effects in Kolsky bar testing of extra-soft specimens SO EXPERIMENTAL MECHANICS LA English DT Article DE Kolsky bar; impact testing; radial inertia effect; extra-soft material ID HOPKINSON PRESSURE BAR; STRAIN-RATE COMPRESSION; WAVE-PROPAGATION; STRESS; BEHAVIOR; RUBBER AB Impact responses of extra-soft materials, such as ballistic gelatins and biological tissues, are increasingly in demand. The Kolsky bar is a widely used device to characterize high-rate behavior of materials. When a Kolsky bar is used to determine the dynamic compressive response of an extra-soft specimen, a spike-like feature often appears in the initial portion of the measured stress history. It is important to distinguish whether this spike is an experimental artifact or an intrinsic material response. In this research, we examined this phenomenon using experimental, numerical and analytical methods. The results indicate that the spike is the extra stress from specimen radial inertia during the acceleration stage of the axial deformation. Based on this understanding, remedies in both specimen geometry and loading pulse to minimize the artifact are proposed and verified, and thus capture the intrinsic dynamic behavior of the specimen material. C1 Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. RP Chen, WW (reprint author), Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. EM wchen@purdue.edu RI Ge, Yun/B-7661-2012; Song, Bo/D-3945-2011 NR 32 TC 31 Z9 33 U1 0 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD OCT PY 2007 VL 47 IS 5 BP 659 EP 670 DI 10.1007/s11340-006-9017-5 PG 12 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA 212VC UT WOS:000249623900008 ER PT J AU Panzica, GC Viglietti-Panzica, C Mura, E Quinn, MJ Lavoie, E Palanza, P Ottinger, MA AF Panzica, G. C. Viglietti-Panzica, C. Mura, E. Quinn, M. J., Jr. Lavoie, E. Palanza, P. Ottinger, M. A. TI Effects of xenoestrogens on the differentiation of behaviorally-relevant neural circuits SO FRONTIERS IN NEUROENDOCRINOLOGY LA English DT Review DE bisphenol A; DES; DDE; genistein; phytoestrogens; mouse; Japanese quail; endocrine disrupting chemicals; brain sexual differentiation; vasotocin ID ENDOCRINE-DISRUPTING CHEMICALS; MEDIAL PREOPTIC NUCLEUS; ESTROGEN-RECEPTOR-ALPHA; MALE JAPANESE-QUAIL; AROMATASE-IMMUNOREACTIVE CELLS; SEXUALLY DIMORPHIC NUCLEUS; BISPHENOL-A ALTERS; COTURNIX-COTURNIX-JAPONICA; DEPENDENT GENE-EXPRESSION; CENTRAL-NERVOUS-SYSTEM AB It has become increasingly clear that environmental chemicals have the capability of impacting endocrine function. Moreover, these endocrine disrupting chemicals (EDCs) have long term consequences on adult reproductive function, especially if exposure occurs during embryonic development thereby affecting sexual differentiation. Of the EDCs, most of the research has been conducted on the effects of estrogen active compounds. Although androgen active compounds are also present in the environment, much less information is available about their action. However, in the case of xenoestrogens, there is mounting evidence for long-term consequences of early exposure at a range of doses. In this review, we present data relative to two widely used animal models: the mouse and the Japanese quail. These two species long have been used to understand neural, neuroendocrine, and behavioral components of reproduction and are therefore optimal models to understand how these components are altered by precocious exposure to EDCs. In particular we discuss effects of bisphenol A and methoxychlor on the dopaminergic and noradrenergic systems in rodents and the impact of these alterations. In addition, the effects of embryonic exposure to diethylstilbestrol, genistein or ethylene, 1,1-dichloro-2,2-bis(p-chlorophenyl) is reviewed relative to behavioral impairment and associated alterations in the sexually dimorphic parvocellular vasotocin system in quail. We point out how sexually dimorphic behaviors are particularly useful to verify adverse developmental consequences produced by chemicals with endocrine disrupting properties, by examining either reproductive or non-reproductive behaviors. (C) 2007 Elsevier Inc. All rights reserved. C1 Univ Turin, Inst Neurosci, I-10124 Turin, Italy. Univ Turin, Rita Levi Montalcini Ctr, Dept Anat, Neuroendocrinol Lab, I-10124 Turin, Italy. USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, Directorate Toxicol, Aberdeen Proving Ground, MD 21020 USA. Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA. Univ Parma, Dept Evolut & Funct Biol, I-43100 Parma, Italy. RP Panzica, GC (reprint author), Dept Anat Pharmacol & Forens Med, Neuroendocrinol Lab, C so MD Azeglio 52, I-10126 Turin, Italy. EM giancarlo.panzica@unito.it RI Panzica, Giancarlo/C-2685-2008 OI Panzica, Giancarlo/0000-0002-9302-4647 NR 244 TC 40 Z9 45 U1 2 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-3022 J9 FRONT NEUROENDOCRIN JI Front. Neuroendocrinol. PD OCT PY 2007 VL 28 IS 4 BP 179 EP 200 DI 10.1016/j.yfrne.2007.07.001 PG 22 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA 220YK UT WOS:000250193000003 PM 17868795 ER PT J AU van den Broek, JW Jones, DR Godino, J AF van den Broek, Jeffery W. Jones, David R. Godino, John TI Hemodynamically significant upper-GI bleeding after hemoclip application SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID UPPER GASTROINTESTINAL HEMORRHAGE; HEATER PROBE THERMOCOAGULATION; MALLORY-WEISS-SYNDROME; ENDOSCOPIC HEMOCLIP; RANDOMIZED-TRIAL; PEPTIC-ULCER; EPINEPHRINE INJECTION; ESOPHAGEAL DILATION; HEMOSTATIC EFFICACY; ETHANOL INJECTION C1 Brooke Army Med Ctr, Div Gastroenterol, Dept Med, Ft Sam Houston, TX 78234 USA. RP van den Broek, JW (reprint author), Brooke Army Med Ctr, Div Gastroenterol, Dept Med, Ft Sam Houston, TX 78234 USA. NR 32 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD OCT PY 2007 VL 66 IS 4 BP 843 EP 845 DI 10.1016/j.gie.2007.03.007 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 220OO UT WOS:000250166200047 PM 17905033 ER PT J AU Henry, KS Durell, GR AF Henry, K. S. Durell, G. R. TI Cold temperature testing of geotextiles: new, and containing soil fines and moisture SO GEOSYNTHETICS INTERNATIONAL LA English DT Article DE geosynthetics; wide-width strip tensile tests; static puncture; nonwoven polypropylene geotextiles; sub-freezing temperatures AB A test program examined the behavior of geotextiles at very low temperatures, and tested the hypothesis that the presence of soil fines and moisture would result in decreased strength values compared with geotextiles at cold temperatures. Wide-width strip tensile and static puncture tests were performed on needle-punched nonwoven polypropylene geotextiles at 20 degrees, 0 degrees, -20 degrees, -40 degrees and -54 degrees C for the wide- width strip tests and at -51 degrees C for the puncture tests on new specimens and specimens that contained soil and moisture. At all sub-freezing temperatures, the specimens that contained ice and soil were much stronger and more brittle in tension than the new specimens. Soil and moisture did not significantly influence puncture strength. C1 US Army Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Res Civil Engn, Hanover, NH 03755 USA. RP Henry, KS (reprint author), US Army Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Res Civil Engn, Hanover, NH 03755 USA. EM Karen.S.Henry@erdc.usace.army.mil; Glenn.D.Durell@erdc.usace.army.mil NR 16 TC 1 Z9 2 U1 0 U2 1 PU THOMAS TELFORD PUBLISHING PI LONDON PA THOMAS TELFORD HOUSE, 1 HERON QUAY, LONDON E14 4JD, ENGLAND SN 1072-6349 J9 GEOSYNTH INT JI Geosynth. Int. PD OCT PY 2007 VL 14 IS 5 BP 320 EP 329 DI 10.1680/gein.2007.14.5.320 PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Geology; Materials Science GA 214AC UT WOS:000249707400007 ER PT J AU Allard, JE Risinger, JI Morrison, C Young, G Rose, GS Fowler, J Berchuck, A Maxwell, GL AF Allard, Jay E. Risinger, John I. Morrison, Carl Young, Gregory Rose, G. Scott Fowler, Jeff Berchuck, Andrew Maxwell, G. Larry TI Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas SO GYNECOLOGIC ONCOLOGY LA English DT Article DE folate binding protein; papillary serous; gynecologic tumors ID GYNECOLOGIC-ONCOLOGY-GROUP; DIFFERENT HISTOLOGIC TYPES; GENE-EXPRESSION PROFILES; PHASE-III TRIAL; ENDOMETRIAL CANCER; OVARIAN-CARCINOMA; MICROARRAY ANALYSIS; PROGNOSTIC-FACTOR; SEROUS CARCINOMA; DNA METHYLATION AB Objectives. Oligonucleotide array and tissue microarray analysis (TMA) by our group has revealed that folate binding protein (FOLR1) is overexpressed in some types of uterine cancer, particularly tumors with serous histology. Since FOLR1 overexpression is a frequent event in some types of endometrial carcinoma, we examined the relationship between FOLR1 overexpression and clinical and pathologic features to determine its prognostic relevance. Methods. A tissue microarray (TMA) comprised of primary tumor specimens from 485 patients diagnosed with endometrial adenocarcinoma was used to identify cases characterized by FOLR1 overexpression. A proportional hazards model was used to evaluate the association of FOLR1 overexpression with progression-free survival while accounting for confounding influences. Results. Overexpression of FOLR1 was observed in 50/292 (17%) cases and was seen more often in poorly differentiated cancers (22/90 [24%], p=0.051) and tumors with serous histology (16/32 [50%], p<0.001). A shorter progress ion-free survival was noted in patients with FOLR1 overexpression (log-rank p=0.016) that persisted when the data were limited to patients with stage III/IV disease (log-rank p=0.021) or serous tumors (log-rank p=0.020). Multivariate Cox regression analysis revealed that patients with FOLR1 overexpression had a shorter progression-free survival (H.R. 2.14; 95% CI 1.07-4.28) even when controlling for stage, grade, myometrial invasion and adjuvant chemotherapy. Conclusions. Our data show that FOLR1 overexpression is not only a biomarker associated with endometrial cancer, but it also appears to be a prognostic factor associated with adverse outcome. These findings suggest that FOLR1 may be an appealing target for biological therapies in some types of endometrial carcinomas. (C) 2007 Published by Elsevier Inc. C1 Walter Reed Army Med Ctr, US Mil Canc Inst, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. Ohio State Univ, Curtis & Elizabeth Anderson Canc Ctr, Dept Oncol, Res Lab, Columbus, OH 43210 USA. Ohio State Univ, Arthur James Canc Ctr, Dept Pathol, Div Gynecol Oncol, Columbus, OH 43210 USA. Duke Univ, Med Ctr, Durham, NC USA. RP Maxwell, GL (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM george.maxwell@us.army.mil NR 34 TC 31 Z9 34 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD OCT PY 2007 VL 107 IS 1 BP 52 EP 57 DI 10.1016/j.ygyno.2007.05.018 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 220YG UT WOS:000250192600009 PM 17582475 ER PT J AU Yurkovetsky, Z Ta'asan, S Skates, S Rand, A Lomakin, A Linkov, F Marrangoni, A Velikokhatnaya, L Winans, M Gorelik, E Maxwell, GL Lu, K Lokshin, A AF Yurkovetsky, Zoya Ta'asan, Shlomo Skates, Steve Rand, Alex Lomakin, Aleksey Linkov, Faina Marrangoni, Adele Velikokhatnaya, Lyudmila Winans, Matthew Gorelik, Elieser Maxwell, G. Larry Lu, Karen Lokshin, Anna TI Development of multimarker panel for early detection of endometrial cancer. High diagnostic power of prolactin SO GYNECOLOGIC ONCOLOGY LA English DT Article DE endometrial cancer; cancer markers; early detection; multiplex profiling; prolactin ID STAGE OVARIAN-CANCER; SERUM CA-125 LEVELS; GYNECOLOGIC CANCER; PERIPHERAL-BLOOD; TUMOR-MARKERS; AMYLOID-A; CARCINOMA; IMMUNE; RESPONSES; CELLS AB Objective. Endometrial carcinoma is the most common gynecologic cancer. Although the prognosis for endometrial cancer is generally good, cancers identified at late stages are associated with high levels of morbidity and mortality. Therefore, prevention and early detection may further reduce the burden of this challenging disease. Methods. A panel of 64 serum biomarkers was analyzed in sera of patients with stages I-III endometrial cancer and age-matched healthy women, utilizing a multiplex xMAP(TM) bead-based immunoassay. For multivariate analysis, four different statistical classification methods were used: logistic regression (LR), separating hyperplane (SHP), k nearest neighbors (KNN), and classification tree (CART). For each of these classifiers, a diagnostic model was created based on the cross-validation set consisting of sera from 115 patients with endometrial cancer and 135 healthy women. Results. Our data have demonstrated that patients with endometrial cancer have significantly different expression patterns of several serum biomarkers as compared to healthy controls. Prolactin was the strongest discriminative biomarker for endometrial cancer providing 98.3% sensitivity and 98.0% specificity alone. Our results have revealed that serum concentration of cancer antigens, including CA 125, CA 15-3, and CEA are higher in patients will Stage III endometrial cancer as compared to those with Stage I. In addition, we have shown that the expression of CA 125, AFP, and ACTH is elevated in women with tumor grade 3 vs. grade 1. Furthermore, five-biomarker panel (prolactin, GH, Eotaxin, E-selectin, and TSH) identified in this study was able to discriminate endometrial cancer from ovarian and breast cancers with high sensitivity and specificity. Conclusions. The ability of prolactin to accurately discriminate between cancer and control groups indicates that this biomarker could potentially be used for development of btood-based test for the early detection of endometrial cancer in high-risk populations. Combining the information on multiple serum markers using flexible statistical methods allows for achieving high cancer selectivity. (C) 2007 Elsevier Inc. All rights reserved. C1 Univ Pittsburgh, Hillman Canc Ctr, Inst Canc, Pittsburgh, PA 15213 USA. Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA USA. Carnegie Mellon Univ, Dept Math Sci, Pittsburgh, PA 15213 USA. Massachusetts Gen Hosp, Ctr Biostat, Boston, MA 02114 USA. MIT, Dept Phys, Cambridge, MA 02139 USA. Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA. Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA USA. Walter Reed Army Med Ctr, US Mil Canc Inst, Gynecol Dis Ctr, Washington, DC 20307 USA. Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA. RP Lokshin, A (reprint author), Univ Pittsburgh, Hillman Canc Ctr, Inst Canc, 5117 Ctr Ave, Pittsburgh, PA 15213 USA. EM lokshina@pitt.edu RI Ta'asan, Shlomo/B-8366-2017 OI Ta'asan, Shlomo/0000-0002-6085-7124 FU NCATS NIH HHS [UL1 TR000005]; NCI NIH HHS [R03 CA136019, R01 CA098642, R01 CA098642-03, R01 CA098642-01A1, R01 CA098642-04, U01 CA117452, U01 CA117452-01, R01 CA108990, R01 CA108990-02, R01 CA108990-01A1, R03 CA136019-01, R01 CA108990-04, U01 CA117452-03, R01 CA098642-02, U01 CA117452-04S1, U01 CA117452-02, U01 CA117452-04, R01 CA108990-03] NR 50 TC 53 Z9 55 U1 0 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD OCT PY 2007 VL 107 IS 1 BP 58 EP 65 DI 10.1016/j.ygyno.2007.05.041 PG 8 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 220YG UT WOS:000250192600010 PM 17659325 ER PT J AU Pockros, PJ Nelson, D Godofsky, E Rodriguez-Torres, M Everson, G Fried, MW Ghalib, RH Harrison, SA Nyberg, LM Shiffman, ML Hill, GZ Chan, A AF Pockros, Paul J. Nelson, David Godofsky, Eliot Rodriguez-Torres, Maribel Everson, Greg Fried, Michael W. Ghalib, Reem H. Harrison, Stephen A. Nyberg, Lisa M. Shiffman, Mitchell L. Hill, George Z. Chan, Anna TI Robust synergistic antiviral effect of R1626 in combination with peginterferon alfa-2a (400), with or without ribavirin - Interim analysis results of Phase 2a study SO HEPATOLOGY LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 02-06, 2007 CL Boston, MA SP Amer Assoc Study Liver Dis C1 Scripps Clin, La Jolla, CA 32611 USA. Univ Florida, Gainesville, FL USA. Univ Hepatitis Ctr, Bradenton, FL USA. Fdn Invest Diego, Santurce, PR 80309 USA. Univ Colorado, Hlth Sci Ctr, Boulder, CO USA. Liver Inst Dallas Methodist Hosp, Dallas, TX USA. Brooke Army Med Ctr, Houston, TX USA. Kaiser Permanente Med Ctr, San Diego, CA USA. McGuire Va Med Ctr, Richmond, VA USA. Roche, Palo Alto, CA USA. Roche, Nutley, NJ USA. NR 0 TC 19 Z9 21 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2007 VL 46 IS 4 SU S MA 167 BP 311A EP 311A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 216WT UT WOS:000249910400173 ER PT J AU Cusi, K Belfort, R Harrison, S Balas, B Schenker, S Darland, C Gastaldelli, A Brown, K Hardies, J AF Cusi, Kenneth Belfort, Renata Harrison, Steve Balas, Bogdan Schenker, Stephen Darland, Celia Gastaldelli, Amalia Brown, Kenneth Hardies, Jean TI Pioglitazone enhances hepatic, muscle and adipose tissue insulin sensitivity and amelioraties systemic inflammation in patients with IGT or T2DM and NASH SO HEPATOLOGY LA English DT Meeting Abstract CT 58th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY NOV 02-06, 2007 CL Boston, MA SP Amer Assoc Study Liver Dis C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. RI Hardies, Lou /F-2102-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2007 VL 46 IS 4 SU S MA 1122 BP 736A EP 736A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 216WT UT WOS:000249910401385 ER PT J AU Wahren, B Brave, A Ljungberg, K Gudmundsdotter, L Boberg, A Cox, J Robb, M Marovich, M Earl, P Moss, B Nilsson, C Biberfeld, G Sandstrom, E AF Wahren, Britta Brave, Andreas Ljungberg, Karl Gudmundsdotter, Lindvi Boberg, Andreas Cox, Josephine Robb, Merlin Marovich, Mary Earl, Patricia Moss, Bernard Nilsson, Charlotta Biberfeld, Gunnel Sandstrom, Eric TI Potent cellular and humoral immunity against HIV-1 elicited preclinically and clinically by a DNA-prime/MVA-boost vaccine regimen SO HUMAN GENE THERAPY LA English DT Meeting Abstract CT 15th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy CY OCT 27-30, 2007 CL Rotterdam, NETHERLANDS SP European Soc Gene & Cell Therapy C1 [Wahren, Britta; Brave, Andreas; Ljungberg, Karl; Gudmundsdotter, Lindvi; Boberg, Andreas; Nilsson, Charlotta; Biberfeld, Gunnel] Karolinska Inst, Stockholm, Sweden. [Cox, Josephine; Robb, Merlin; Marovich, Mary] Walter Reed Army Inst Res, Rockville, MD USA. [Earl, Patricia; Moss, Bernard] NIH, NIAID, Lab Viral Dis, Bethesda, MD USA. [Sandstrom, Eric] Karolinska Univ Hosp, Stockholm, Sweden. EM Britta.Wahren@smi.ki.se NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD OCT PY 2007 VL 18 IS 10 BP 962 EP 962 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 222ZU UT WOS:000250339500055 ER PT J AU Goldberg, H Kwon, H Nasrabadi, NM AF Goldberg, H. Kwon, H. Nasrabadi, N. M. TI Kernel eigenspace separation transform for subspace anomaly detection in hypprspectral imagery SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE anomaly detection; eigenspace separation transform (EST); hyperspectral imagery; kernel-based machine learning; kernels ID HYPERSPECTRAL IMAGERY; NEURAL-NETWORK AB This letter proposes a nonlinear version of the eigenspace separation transform (EST) for subspace anomaly detection in hyperspectral imaging. The EST is defined in terms of the eigenvectors of the difference correlation matrix (DCOR) obtained using the data from the two classes. Using ideas found in the machine learning literature (i.e., the kernel trick), a nonlinear version-kernel EST (KEST)-is achieved by expressing the DCOR in terms of dot products in feature space and replacing all dot products with a Mercer kernel function that is defined in terms of input data space. Experimental results indicate that KEST outperforms many other commonly used subspace anomaly detection algorithms. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Goldberg, H (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM hirsh.goldberg@arl.army.mil; nnasraba@arl.army.mil NR 15 TC 18 Z9 20 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1545-598X J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD OCT PY 2007 VL 4 IS 4 BP 581 EP 585 DI 10.1109/LGRS.2007.905083 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 223RL UT WOS:000250389900017 ER PT J AU Sadler, BM Goeckel, D Honig, ML van der Veen, AJ Xu, ZY AF Sadler, Brian M. Goeckel, Dennis Honig, Michael L. Van der Veen, Alle-Jan Xu, Zhengyuan TI Introduction to the Issue on Performance Limits of Ultra-Wideband Systems SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING LA English DT Editorial Material C1 [Sadler, Brian M.] AMSRD ARL CI CN, Army Res Lab, Adelphi, MD 20783 USA. [Goeckel, Dennis] Univ Massachusetts, Dept Elect & Comp Engn, Amherst, MA 01003 USA. [Honig, Michael L.] Northwestern Univ, Dept Elect Engn & Comp Sci, Evanston, IL 60201 USA. [Van der Veen, Alle-Jan] Delft Univ Technol, DIMES, Delft, Netherlands. [Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. RP Sadler, BM (reprint author), AMSRD ARL CI CN, Army Res Lab, Adelphi, MD 20783 USA. RI Honig, Michael/B-7173-2009; van der Veen, Alle-Jan/K-3910-2012 NR 0 TC 1 Z9 1 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1932-4553 J9 IEEE J-STSP JI IEEE J. Sel. Top. Signal Process. PD OCT PY 2007 VL 1 IS 3 BP 337 EP 339 DI 10.1109/JSTSP.2007.907414 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA V04IY UT WOS:000207053300001 ER PT J AU Xu, ZY Sadler, BM AF Xu, Zhengyuan Sadler, Brian M. TI Time Delay Estimation Bounds in Convolutive Random Channels SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING LA English DT Article DE Convolutive channel; performance analysis; time delay estimation; ultra-wideband; Ziv-Zakai bound AB We develop bounds on time delay estimation (TDE) in wideband convolutive random channels. The improved Ziv-Zakai bound (ZZB) is adapted to this case, resulting in mean-square error (MSE) bounds that are independent of estimator bias, and avoid regularity conditions. We assume a known transmitted signal, a tapped delay line random channel model, and a uniform prior on the delay. The taps are modeled as Gaussian, including non-zero mean and possible correlation between taps. The channel model may be tuned to a variety of environments through the choice of mean and covariance, and models wideband and ultra-wideband line of sight (LOS) and non-LOS (NLOS) cases. Flat fading is a simple special case with one tap. The channel power delay profile is incorporated through the tap covariance matrix, and results for an exponential power delay profile are given. We derive the ZZB for a given channel realization, and then average over the random channel model. The resulting bound reflects the impact of the random channel, providing an average MSE performance bound, that assumes perfect channel estimates are available to the receiver. Specific cases and examples illustrate the impact of the key system, channel, and signal parameters. C1 [Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] AMSRD ARL CI CN, Army Res Lab, Adelphi, MD 20783 USA. RP Xu, ZY (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu; bsadler@arl.army.mil NR 42 TC 17 Z9 17 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1932-4553 J9 IEEE J-STSP JI IEEE J. Sel. Top. Signal Process. PD OCT PY 2007 VL 1 IS 3 BP 418 EP 430 DI 10.1109/JSTSP.2007.906581 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA V04IY UT WOS:000207053300008 ER PT J AU Lai, HQ Siriwongpairat, WP Liu, KJR AF Lai, Hung-Qluoc Siriwongpairat, W. Pam Liu, K. J. Ray TI Performance Analysis of Multiband OFDM UWB Systems With Imperfect Synchronization and Intersymbol Interference SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING LA English DT Article DE Bit-error rate; carrier-frequency offset; frequency synchronization; intercarrier interference; intersymbol interference; MB-OFDM; multipath fading channel; timing synchronization; ultra-wideband (UWB) AB This paper provides performance analysis of MB-OFDM UWB systems that not only captures the characteristics or realistic ultra-wideband (UWB) channels, but also takes into consideration of the imperfection of the frequency and timing synchronizations and the effect of intersymbol interference. The systems are considered in multipath fading channels, the IEEE 802.15.3a channel Standard, with four channel models: CM1, CM2, CM3, and CM4. These channel models are characterized by cluster arrival rate, ray arrival rate within clusters, and cluster and ray decay factors. First, an average signal-to-noise ratio with imperfect synchronizations and intersymbol interference is derived. Then a closed-form bit error rate performance formulation that provides insightful understanding of the system performance in various synchronization conditions is obtained under Rayleigh fading assumption. This analytical performance formulation serves as an upper bound on the bit error rate performance of UWB systems. Finally, simulation results under various channel and synchronization conditions are provided to validate the theoretical analysis. C1 [Lai, Hung-Qluoc] USA, RDECOM CERDEC, Ft Monmouth, NJ 07703 USA. [Siriwongpairat, W. Pam] Meteor Commun Corp, Kent, WA 98032 USA. [Liu, K. J. Ray] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Liu, K. J. Ray] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA. RP Lai, HQ (reprint author), USA, RDECOM CERDEC, Ft Monmouth, NJ 07703 USA. EM hungquoc.lai@us.army.mil; PSiriwongpairat@meteorcomm.com; kjrliu@eng.umd.edu RI Liu, K. J. Ray/C-2798-2009 FU U.S. Army RDECOM CERDEC FX This work was supported in part by the U.S. Army RDECOM CERDEC. The associate editor coordinating the review of this manuscript and approving it for publication was Prof. Dennis L. Goeckel. NR 17 TC 12 Z9 13 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1932-4553 J9 IEEE J-STSP JI IEEE J. Sel. Top. Signal Process. PD OCT PY 2007 VL 1 IS 3 BP 521 EP 534 DI 10.1109/JSTSP.2007.906650 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA V04IY UT WOS:000207053300016 ER PT J AU Zhang, HF Turner, JA Yang, J Kosinski, JA AF Zhang, Haifeng Turner, Joseph A. Yang, Jiashi Kosinski, John A. TI Electroelastic effect of thickness mode langasite resonators SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID DC-BIAS; FREQUENCY; QUARTZ; LA3GA5SIO14; LANGATATE; LANGANITE; EQUATIONS; FIELDS AB Langasite is a very promising material for resonators due to its good temperature behavior and high piezoelectric coupling, low acoustic loss, and high Q factor. The biasing effect for langasite resonators is crucial for resonator design. In this article, the resonant frequency shift of a thickness-mode langasite resonator is analyzed with respect to a direct current (DC) electric field applied in the thickness direction. The vibration modes of a thin langasite plate fully coated with an electrode are analyzed. The analysis is based on the theory for small fields superposed on a bias in electroelastic bodies and the first-order perturbation integral theory. The electroelastic effect of the resonator is analyzed by both analytical and finite-element methods. The complete set of nonlinear elastic, piezoelectric, dielectric permeability, and electrostrictive constants of langasite is used in the theoretical and numerical analysis. The sensitivity of electroelastic effect to nonlinear material constants is analyzed. C1 Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA. USA, RDECOM, CERDEC, Ft Monmouth, NJ 07703 USA. RP Zhang, HF (reprint author), Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA. EM hfzhang@bigred.unl.edu RI Turner, Joseph/F-5165-2010 NR 21 TC 8 Z9 8 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD OCT PY 2007 VL 54 IS 10 BP 2120 EP 2128 DI 10.1109/TUFFC.2007.507 PG 9 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 222EH UT WOS:000250278400025 PM 18019250 ER PT J AU Mahoney, PF Steinbruner, D Mazur, R Dodson, C Mehta, SG AF Mahoney, Peter F. Steinbruner, David Mazur, Robert Dodson, Charles Mehta, Sumeru G. TI Cervical spine protection in a combat zone SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Letter ID NECK; TRAUMA C1 Royal Ctr Def Med, Birmingham, W Midlands, England. Ibn Sina Hosp, Combat Support Hosp 10, Dept Emergency Med, Baghdad, Iraq. Evans Army Community Hosp, Ft Carson, CO USA. Winn Army Community Hosp, Ft Stewart, GA USA. Reynolds Army Community Hosp, Ft Sill, OK USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Ibn Sina Hosp, Combat Support Hosp 10, Dept Anesthesiol, Baghdad, Iraq. RP Mahoney, PF (reprint author), Royal Ctr Def Med, Birmingham, W Midlands, England. EM peterfmahoney@aot.com NR 8 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD OCT PY 2007 VL 38 IS 10 BP 1220 EP 1222 DI 10.1016/j.injury.2007.05.012 PG 3 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 229GS UT WOS:000250791900020 PM 17884051 ER PT J AU Tannenbaum, LV AF Tannenbaum, Lawrence V. TI And So We Model: The Ineffective Use of Mathematical Models in Ecological Risk Assessments SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Letter C1 [Tannenbaum, Lawrence V.] US Army, Ctr Hlth Promot & Prevent Med, MCHB TS REH, Bldg 1675, Aberdeen Proving Ground, MD 21010 USA. RP Tannenbaum, LV (reprint author), US Army, Ctr Hlth Promot & Prevent Med, MCHB TS REH, Bldg 1675, Aberdeen Proving Ground, MD 21010 USA. EM larry.tannenbaum@us.army.mil NR 6 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD OCT PY 2007 VL 3 IS 4 BP 473 EP 475 DI 10.1002/ieam.5630030401 PG 3 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA V43XC UT WOS:000209713100002 PM 18046795 ER PT J AU Perkins, EJ Gust, KA Steevens, J AF Perkins, Edward J. Gust, Kurt A. Steevens, Jeffery TI TOXICOGENOMIC ASSESSMENT OF THE POPULATION LEVEL IMPACTS OF CONTAMINANTS SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Editorial Material C1 [Perkins, Edward J.; Gust, Kurt A.; Steevens, Jeffery] US Army, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Perkins, EJ (reprint author), US Army, Engineer Res & Dev Ctr, Vicksburg, MS USA. EM edward.j.perkins@erdc.usace.army.mil NR 6 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD OCT PY 2007 VL 3 IS 4 BP 562 EP 564 DI 10.1002/ieam.5630030414 PG 4 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA V43XC UT WOS:000209713100014 PM 18046807 ER PT J AU Huestis, MA Darwin, WD Shimomura, E Lalani, SA Trinidad, DV Jenkins, AJ Cone, EJ Jacobs, AJ Smith, ML Paul, BD AF Huestis, Marilyn A. Darwin, W. David Shimomura, Eric Lalani, Shairose A. Trinidad, Daniel V. Jenkins, Amanda J. Cone, Edward J. Jacobs, Aaron J. Smith, Michael L. Paul, Buddha D. TI Cocaine and metabolites urinary excretion after controlled smoked administration SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID DIFFERENT ROUTES; BENZOYLECGONINE; ELIMINATION; STABILITY; ECGONINE; HUMANS; PLASMA C1 Natl Inst Drug Abuse, Natl Inst Hlth, Chem & Drug Metabol Intramural Res Program, Baltimore, MD 21224 USA. Armed Forces Inst Pathol, Off armed Forces Med Examiner, Div Forensic Toxicol, Rockville, MD USA. Off Cuyahoga Country Coroner, Cleveland, OH USA. Johns Hopkins Sch Med, Baltimore, MD USA. US Army Med Dept Board, Houston, TX USA. RP Huestis, MA (reprint author), Natl Inst Drug Abuse, Natl Inst Hlth, Chem & Drug Metabol Intramural Res Program, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA. EM mhuestis@intra.nida.nih.gov FU Intramural NIH HHS [Z01 DA000413-10] NR 16 TC 16 Z9 18 U1 0 U2 10 PU PRESTON PUBL INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD OCT PY 2007 VL 31 IS 8 BP 462 EP 468 PG 7 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 222SX UT WOS:000250318600006 PM 17988460 ER PT J AU Levine, B Cox, D Jufer-Phipps, RA Li, L Jacobs, A Fowler, D AF Levine, Barry Cox, Dawn Jufer-Phipps, Rebecca A. Li, Ling Jacobs, Aaron Fowler, David TI A fatality from sevoflurane abuse SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID ISOFLURANE ABUSE; ENFLURANE; PHARMACOKINETICS C1 Off Chief Med Examiner State Maryland, Baltimore, MD 21201 USA. Off Armed Forces Med Examiner, Rockville, MD 20850 USA. USA, San Antonio, TX 78258 USA. RP Levine, B (reprint author), Off Chief Med Examiner State Maryland, 111 Penn St, Baltimore, MD 21201 USA. EM blevi001@umaryland.edu NR 12 TC 3 Z9 3 U1 0 U2 0 PU PRESTON PUBL INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD OCT PY 2007 VL 31 IS 8 BP 534 EP 536 PG 3 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 222SX UT WOS:000250318600015 PM 17988469 ER PT J AU Cox, D Phipps, RAJ Levinel, B Jacobs, A Fowler, D AF Cox, Dawn Phipps, Rebecca A. Jufer Levinel, Barry Jacobs, Aaron Fowler, David TI Distribution of phencyclidine into vitreous humor SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article C1 Off Armed Forces Med Examiner, Div Forens Toxicol, Rockville, MD 20850 USA. Off Chief Med Examiner, Baltimore, MD 21201 USA. USA, San Antonio, TX USA. RP Levinel, B (reprint author), Off Armed Forces Med Examiner, Div Forens Toxicol, 1413 Res Blvd,Bldg 102, Rockville, MD 20850 USA. EM blevi001@umaryland.edu NR 7 TC 12 Z9 12 U1 2 U2 3 PU PRESTON PUBL INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD OCT PY 2007 VL 31 IS 8 BP 537 EP 539 PG 3 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 222SX UT WOS:000250318600016 PM 17988470 ER PT J AU Edstein, MD Kotecka, BM Ager, AL Smith, KS DiTusa, CA Diaz, DS Kyle, DE Schiehser, GA Jacobus, DP Rieckmann, KH O'Neil, MT AF Edstein, Michael D. Kotecka, Barbara M. Ager, Arba L. Smith, Kirsten S. DiTusa, Charles A. Diaz, Damaris S. Kyle, Dennis E. Schiehser, Guy A. Jacobus, David P. Rieckmann, Karl H. O'Neil, Michael T. TI Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate JPC2056 in cynomolgus monkeys using an in vivo in vitro model SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY LA English DT Article DE malaria; antifolates; WR99210; JPC2056; DHFR inhibitors ID REDUCTASE-THYMIDYLATE SYNTHASE; PLASMODIUM-FALCIPARUM MALARIA; PAPUA-NEW-GUINEA; DIHYDROFOLATE-REDUCTASE; SULFADOXINE-PYRIMETHAMINE; EXPRESSION SYSTEM; DRUG-RESISTANCE; DHFR ALLELES; MUTATIONS; GENE AB Objectives: To assess the antimalarial pharmacodynamics and pharmacokinetics of the novel dihydrofolate reductase ( DHFR) inhibitor, JPC2056 and its principal active metabolite JPC2067 in cynomolgus monkeys using an in vivo-in vitro model. Methods: In a two-phase crossover design, five cynomolgus monkeys were administered a single dose ( 20 mg/kg) and multiple doses ( 20 mg/kg daily for 3 days) of JPC2056. Plasma samples collected from treated monkeys were assessed for in vitro antimalarial activity against Plasmodium falciparum lines having wild-type ( D6), double-mutant ( K1) and quadruple-mutant ( TM90-C2A) DHFR-thymidylate synthase ( TS) and a P. falciparum line transformed with a Plasmodium vivax dhfr-ts quadruple-mutant allele ( D6-PvDHFR). Plasma JPC2056 and JPC2067 concentrations were measured by LC-mass spectrometry. Results: The mean inhibitory dilution ( ID90) of monkey plasma at 3 h after drug administration against D6, K1 and TM90-C2A was, respectively, 1253, 585 and 869 after the single-dose regimen and 1613, 1120 and 1396 following the multiple-dose regimen. Less activity was observed with the same monkey plasma samples against the D6-PvDHFR line, with a mean ID90 of 53 after multiple dosing. Geometric mean plasma concentrations of JPC2056 and JPC2067 at 3 h after drug administration were, respectively, 113 and 12 ng/mL after the single dose and 150 and 17 ng/mL after multiple dosing. The mean elimination half-life of JPC2056 was shorter than its metabolite after both regimens ( single dose, 7.3 versus 11.8 h; multiple doses, 6.6 versus 11.1 h). Conclusions: The high potency of JPC2056 against P. falciparum DHFR-TS quadruple-mutant lines provides optimism for the future development of JPC2056 for the treatment of malaria infections. C1 Australian Army Malaria Inst, Enoggera, Qld 4051, Australia. Univ Miami, Sch Med, Miami, FL USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. Jacobus Pharmaceut Co, Princeton, NJ USA. RP Edstein, MD (reprint author), Australian Army Malaria Inst, Enoggera, Qld 4051, Australia. EM mike.edstein@defence.gov.au RI DiTusa, Charles/A-9143-2011 NR 49 TC 9 Z9 9 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-7453 J9 J ANTIMICROB CHEMOTH JI J. Antimicrob. Chemother. PD OCT PY 2007 VL 60 IS 4 BP 811 EP 818 DI 10.1093/jac/dkm280 PG 8 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA 216NI UT WOS:000249884400015 PM 17646199 ER PT J AU Bourne, NK Millett, JCF Chen, MW McCauley, JW Dandekar, DP AF Bourne, N. K. Millett, J. C. F. Chen, Mingwei McCauley, J. W. Dandekar, D. P. TI On the Hugoniot elastic limit in polycrystalline alumina SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HIGH-STRAIN RATES; LATERAL STRESS; SHOCK-WAVE; BRITTLE SOLIDS; HIGH-PRESSURES; STRENGTH; SAPPHIRE; CERAMICS; FAILURE; PROPAGATION AB The use of polycrystalline ceramics in engineering applications requires a better knowledge of microstructural response than exists at present. The continuum response of the alumina AD995 to shock loading has been extensively investigated. This work aims to connect microstructural response with continuum observations. Over recent years, workers have reported failure in various polycrystalline ceramics occurring behind a propagating front running behind the shock. These phenomena have been investigated using embedded stress sensors and a recovery technique that has allowed the observation of the microstructure above and below the Hugoniot elastic limit (HEL). These results are brought together here to explain the observed behavior. The failure front velocity is found to change with the applied stress, in particular, it slows markedly as the HEL is exceeded. Further, the curvature of histories recorded by sensors may be related to the observed response. The evidence in the microstructure shows that the response below HEL is dominated by the intergranular failure, while above it by plasticity in grains (including twinning), which alters the deformation and failure characteristics. These microstructural features are combined with the continuum observations to review the response of the alumina. (C) 2007 American Institute of Physics. C1 AWE, Reading RG7 4PR, Berks, England. Tohoku Univ, Mat Res Inst, Sendai, Miyagi 9808577, Japan. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Bourne, NK (reprint author), AWE, Reading RG7 4PR, Berks, England. EM neil.bourne@mac.com RI Bourne, Neil/A-7544-2008; Chen, Mingwei/A-4855-2010 OI Chen, Mingwei/0000-0002-2850-8872 NR 49 TC 16 Z9 16 U1 1 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 2007 VL 102 IS 7 AR 073514 DI 10.1063/1.2787154 PG 9 WC Physics, Applied SC Physics GA 220HL UT WOS:000250147700034 ER PT J AU Cappeddu, MG Savalli, N Baglio, S Scalora, M Davenport, W Bloemer, MJ Larciprete, MC AF Cappeddu, M. G. Savalli, N. Baglio, S. Scalora, M. Davenport, W. Bloemer, M. J. Larciprete, M. C. TI Tunable absorption resonance in electromechanical one-dimensional metallodielectric photonic band gap structures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID TRANSPARENT; FINITE AB We present the results of an experimental study of an electromechanical, one-dimensional, metallodielectric photonic band gap structure. We monitor the reflectance as a function of the thickness of an air gap located inside the stack. The results suggest that, by changing the thickness of the air gap by approximately 20 nm, a large contrast can be achieved between high- and low-reflectance states, as reflectance switches from a fraction of a percent to about 70%. Using this approach, we are able to selectively remove a relatively narrow but tunable wavelength range from the reflected spectrum, thus making possible applications to accelerometers, linear optical switches, modulators, and other specialized filters in the visible range. The characteristic absorption spectrum can be controlled by varying air gap and dielectric layer thicknesses. (C) 2007 American Institute of Physics. C1 Univ Catania, Sensors & Instrumentat Grp DIEES, I-95125 Catania, Italy. USA, RDECOM, Charles M Bowden Res Facil, AMSRD AMR WS ST, Redstone Arsenal, AL 35898 USA. Univ Roma La Sapienza, INFM, I-00161 Rome, Italy. RP Cappeddu, MG (reprint author), Univ Catania, Sensors & Instrumentat Grp DIEES, Vle A Doria 6, I-95125 Catania, Italy. EM mirko.cappeddu@gmail.com RI Baglio, Salvatore/I-3174-2012; OI Baglio, Salvatore/0000-0002-6068-2846; Larciprete, Maria Cristina/0000-0002-7876-628X NR 12 TC 4 Z9 4 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 2007 VL 102 IS 7 AR 073531 DI 10.1063/1.2771073 PG 5 WC Physics, Applied SC Physics GA 220HL UT WOS:000250147700051 ER PT J AU Johnson, ON Fox, CJ White, P Adams, E Cox, M Rich, N Gillespie, DL AF Johnson, O. N., III Fox, C. J. White, P. Adams, E. Cox, M. Rich, N. Gillespie, D. L. TI Physical exam and occult post-traumatic vascular lesions: implications for the evaluation and management of arterial injuries in modem warfare in the endovascular era SO JOURNAL OF CARDIOVASCULAR SURGERY LA English DT Article; Proceedings Paper CT 34th Annual Meeting of the Society-for-Military-Vascular-Surgery CY 2006 CL Bethesda, MD SP Soc Mil Vasc Surg DE angiography; aneurysm, false; arteriovenous fistula; physical examination; trauma; extremities; endovascular surgical procedures; angioplasty, balloon; Iraq; Afghanistan ID ARTERIOVENOUS-FISTULA; TRAUMA; EXTREMITIES; PSEUDOANEURYSM; ARTERIOGRAPHY; PLACEMENT; STENT AB Based on complexity of extremity wounds sustained in recent combat, arteriography had been used routinely in evaluations for delayed or occult arterial injuries. This report aims to quantitatively analyze the sensitivity and specificity of physical exam (PE) in predicting the presence of these injuries. United States servicemembers sustaining extremity trauma in the Global War on Terrorism were evacuated to our medical center and evaluated by a senior vascular surgeon. Those with an abnormal PE, at risk based on wounding patterns, or previously treated for vascular injury underwent arteriography. Data from each patient were prospectively entered into a Vascular injury registry. Comprehensive information about the injuries, interventions, arteriogram results, and any periprocedural complications were analyzed. Twenty-five endovascular or open surgical interventions were performed in forty-six of 99 patients that had lesions on arteriography. Seventy-three patients had a normal PE, of which 36 had lesions that prompted 6 subsequent interventions. Twenty-two of 26 patients with an abnormal PE had lesions that prompted 19 interventions. For PE, sensitivity was 38%, specificity was 90%, and positive predictive value (PPV) and negative predictive value (NPV) were 85% and 51%, respectively. In proximity injuries, PPV improved to 100%, but was only 15% sensitive with a NPV of 60%. In conclusion normal PE did not reliably predict post-traumatic arterial lesions in these military extremity injuries. These lesions are amenable to endovascular therapies, and should be considered in cases of complex trauma involving high amounts of energy, penetrating mechanisms, or wounding patterns in proximity to named vessels. C1 Walter Reed Army Med Ctr, Dept Gen Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Vasc Surg Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Div Vasc Surg, Bethesda, MD USA. RP Johnson, ON (reprint author), Walter Reed Army Med Ctr, Dept Gen Surg, 6900 Georgia Ave,NW, Bldg 2,Ward 5, Washington, DC 20307 USA. EM Owen.Johnson@na.amedd.army.mil NR 15 TC 7 Z9 7 U1 0 U2 2 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0021-9509 J9 J CARDIOVASC SURG JI J. Cardiovasc. Surg. PD OCT PY 2007 VL 48 IS 5 BP 581 EP 586 PG 6 WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Surgery GA 231XV UT WOS:000250983400006 PM 17989627 ER PT J AU Eller, LA Eller, MA Ouma, BJ Kataaha, P Bagaya, BS Olemukan, RL Erima, S Kawala, L de Souza, MS Kibuuka, H Wabwire-Mangen, F Peel, SA O'Connell, RJ Robb, ML Michael, NL AF Eller, Leigh A. Eller, Michael A. Ouma, Benson J. Kataaha, Peter Bagaya, Bernard S. Olemukan, Robert L. Erima, Simon Kawala, Lilian de Souza, Mark S. Kibuuka, Hannah Wabwire-Mangen, Fred Peel, Sheila A. O'Connell, Robert J. Robb, Merlin L. Michael, Nelson L. TI Large-scale human immunodeficiency virus rapid test evaluation in a low-prevalence Ugandan blood bank population SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID DIAGNOSTIC-TEST; HIV; TYPE-1; ANTIBODIES AB The use of rapid tests for human immunodeficiency virus (HIV) has become standard in HIV testing algorithms employed in resource-limited settings. We report an extensive HIV rapid test validation study conducted among Ugandan blood bank donors at low risk for HIV infection. The operational characteristics of four readily available commercial HIV rapid test kits were first determined with 940 donor samples and were used to select a serial testing algorithm. Uni-Gold Recombigen HIV was used as the screening test, followed by HIV-1/2 STAT-PAK for reactive samples. OraQuick HIV-1 testing was performed if the first two test results were discordant. This algorithm was then tested with 5,252 blood donor samples, and the results were compared to those of enzyme immunoassays (ElAs) and Western blotting. The unadjusted algorithm sensitivity and specificity were 98.6 and 99.9%, respectively. The adjusted sensitivity and specificity were 100 and 99.96%, respectively. This HIV testing algorithm is a suitable alternative to ElAs and Western blotting for Ugandan blood donors. C1 Makerere Univ, Walter Reed Project, Kampala, Uganda. US Military Human Immunodeficiency Virus Res Prog, Rockville, MD USA. Uganda Natl Blood Transfus Serv, Kampala, Uganda. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. Henry M Jackson Fdn, Rockville, MD USA. RP Eller, LA (reprint author), Makerere Univ, Fac Med, Pathol Bldg,A-10,Old Mulago Hill Rd,PO Box 16524, Kampala, Uganda. EM leller@muwrp.org NR 18 TC 17 Z9 18 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD OCT PY 2007 VL 45 IS 10 BP 3281 EP 3285 DI 10.1128/JCM.00894-07 PG 5 WC Microbiology SC Microbiology GA 220KS UT WOS:000250156200020 PM 17699650 ER PT J AU De Lorenzo, RA Abbott, CA AF De Lorenzo, Robert A. Abbott, Cynthia A. TI Effect of a focused and directed continuing education program on prehospital skill maintenance in key resuscitation areas SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT 12th Annual Meeting of the Society-for-Academic-Emergency-Medicine CY MAY 19-22, 2002 CL Altanta, GA SP Soc Acad Emergency Med DE emergency medical services; education; continuing; competency-based education ID RETENTION; CARE AB US Army Medics (formerly MOS 91B) received training similar to EMT-B level but were not required to be certified. Medics additionally received training in such skills as intravenous (i.v.) line insertion and fluid resuscitation. Continuing education, although encouraged, was not required. The objective of this study was to determine the effectiveness of a focused and directed psychomotor skills continuing education program in maintaining skills performance over a 6-month period in four key resuscitation areas. The education effect was the focus of the analysis. The study population was a convenience sample of medics with 1-4 years experience assigned to field units at Ft. Hood, TX. Subjects received a pretest evaluation of skills performance in four key areas using standard NREMT skill sheets. Scores on skill evaluations represent the percentage of steps correctly performed. After pretest evaluations, subjects were required to complete a comprehensive and focused continuing education program that emphasized skill practice. After the 6-month pretest, a post-test was conducted. Pre- and post-test scores for each student were matched. A one-tailed Student's t-test was used to compare results before and after the intervention, with statistical significance set at p < 0.05. The total sample of subjects available for the post-test (n =107) was compared to the initial pretest sample (n = 127) and shown to be accurately representative. The pretest performance for the skills of i.v. insertion, airway management, patient assessment, and bleeding control was 79 :L 11, 73 +/- 14, 44 +/- 22, and 57 +/- 13, respectively. The post-test performance for these same skills increased (p < 0.05) in all cases when compared to pretest scores: 87 +/- 9, 76 +/- 15, 73 +/- 19, and 62 +/- 14, respectively. A focused and directed continuing education program that emphasizes skill practice in key resuscitation areas can improve skills performance. (c) 2007 Elsevier Inc. C1 USA, Med Dept Ctr & Sch, Dept Emergency Med, Ft Sam Houston, TX USA. USA, Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, Ft Sam Houston, TX USA. RP De Lorenzo, RA (reprint author), Brooke Army Med Ctr, Dept Emergency Med, MCHE EMR, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 20 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD OCT PY 2007 VL 33 IS 3 BP 293 EP 297 DI 10.1016/j.jemermed.2007.02.060 PG 5 WC Emergency Medicine SC Emergency Medicine GA 230OY UT WOS:000250887000015 PM 17976562 ER PT J AU Kobayashi, T Simon, DL AF Kobayashi, Takahisa Simon, Donald L. TI Integration of on-line and off-line diagnostic algorithms for aircraft engine health management SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 52nd ASME Turbo Expo CY MAY 14-17, 2007 CL Montreal, CANADA SP Amer Soc Mech Engineers, Int Gas Turbine Inst DE in-flight fault detection; trend monitoring; on-board engine model; Kalman filter ID GAS-PATH-ANALYSIS AB This paper investigates the integration of on-line and off-line diagnostic algorithms for aircraft gas turbine engines. The on-line diagnostic algorithm is designed for in-flight fault detection. It continuously monitors engine outputs for anomalous signatures induced by faults. The off-line diagnostic algorithm is designed to track engine health degradation over the lifetime of an engine. It estimates engine health degradation periodically over the course of the engine's life. The estimate generated by the off-line algorithm is used to "update" the on-line algorithm. Through this integration, the on-line algorithm becomes aware of engine health degradation, and its effectiveness to detect faults can be maintained while the engine continues to degrade. The benefit of this integration is investigated in a simulation environment using a nonlinear engine model. C1 ASRC Aerosp Corp, Cleveland, OH 44135 USA. Glenn Res Ctr, US Army Res Lab, Cleveland, OH 44135 USA. RP Kobayashi, T (reprint author), ASRC Aerosp Corp, 21000 Brookpk Rd, Cleveland, OH 44135 USA. NR 20 TC 3 Z9 5 U1 2 U2 9 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD OCT PY 2007 VL 129 IS 4 BP 986 EP 993 DI 10.1115/1.2747640 PG 8 WC Engineering, Mechanical SC Engineering GA 223EP UT WOS:000250352700013 ER PT J AU Fang, S Gertner, GZ Anderson, AB AF Fang, Shoufan Gertner, George Z. Anderson, Alan B. TI The effect of model structure and data in modeling land conditions in disturbed complex ecosystems SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE ANOVA; disturbance to ecosystems; interaction; logistic model; soil erosion ID FORT HOOD; VEGETATION AB Off-road vehicles increase soil erosion by reducing vegetation cover and other types of ground cover, and by changing the structure of soil. The investigation of the relationship between disturbance from off-road vehicles and the intensity of the activities that involve use of vehicles is essential for water and soil conservation and facility management. Models have been developed in a previous study to predict disturbance caused by off-road vehicles. However, the effect of data on model quality and model performance, and the appropriate structure of models have not been previously investigated. In order to improve the quality and performance of disturbance models, this study was designed to investigate the effects of model structure and data. The experiment considered and tested: (1) two measures of disturbance based on the Vegetation Cover Factor (C Factor) of the Revised Universal Soil Loss Equation (RUSLE) and Disturbance Intensity; (2) model structure using two modeling approaches; and (3) three subsets of data. The adjusted R-square and residuals from validation data are used to represent model quality and performance, respectively. Analysis of variance (ANOVA) is used to identify factors which have significant effects on model quality and performance. The results of the ANOVA show that subsets of data have significant effects on both model quality and performance for both measures of disturbance. The ANOVA also detected that the C Factor models have higher quality and performance than the Disturbance models. Although modeling approaches are not a significant factor based on the ANOVA tests, models containing interaction terms can increase the adjusted R-squares for nearly all tested conditions and the maximum improvement can reach 31%). (c) 2006 Elsevier Ltd. All rights reserved. C1 Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. Univ Alberta, Dept Renewable Resources, Edmonton, AB T6G 2H1, Canada. USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61822 USA. RP Gertner, GZ (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, W503 Turner Hall 1102 S Goodwin Ave, Urbana, IL 61801 USA. EM gertner@uiuc.edu NR 23 TC 2 Z9 2 U1 0 U2 1 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD OCT PY 2007 VL 85 IS 1 BP 69 EP 77 DI 10.1016/j.jenvman.2006.08.002 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 205UF UT WOS:000249139400007 PM 17030403 ER PT J AU Balas, B Belfort, R Harrison, SA Darland, C Finch, J Schenker, S Gastaldelli, A Cusi, K AF Balas, Bogdan Belfort, Renata Harrison, Stephen A. Darland, Celia Finch, Joan Schenker, Steven Gastaldelli, Amalia Cusi, Kenneth TI Pioglitazone treatment increases whole body fat but not total body water in patients with non-alcoholic steatohepatitis SO JOURNAL OF HEPATOLOGY LA English DT Article DE non-alcoholic steatohepatitis (NASH); pioglitazone; total body fat; total body water ID RANDOMIZED CONTROLLED-TRIAL; CONGESTIVE-HEART-FAILURE; PLACEBO-CONTROLLED TRIAL; TYPE-2 DIABETIC-PATIENTS; INSULIN SENSITIVITY; BIOELECTRICAL-IMPEDANCE; GLYCEMIC CONTROL; ENERGY-EXPENDITURE; METFORMIN; THIAZOLIDINEDIONES AB Background/Aims: Non-Alcoholic Steatohepatitis (NASH) is a chronic liver disease frequently associated with insulin resistance and type 2 diabetes mellitus (T2DM). Pioglitazone reverses the metabolic and histological abnormalities of patients with impaired glucose tolerance or T2DM and NASH, but also leads to weight gain. To understand the nature of weight gain associated with pioglitazone treatment in NASH we analyzed 35 patients who completed tests for determination of whole body fat (WBF) and total body water (TBW). Methods: Twenty-one patients received pioglitazone and 14 placebo in a double-blind, randomized fashion for a period of 6 months. WBF and TBW were measured before and after treatment using DXA, a water dilution technique and bioimpedance. Results: Pioglitazone increased body weight (from 93.6 +/- 4.2 to 96.1 +/- 4.5 kg, p < 0.003) and WBF measured with DXA (from 32.9 +/- 2.1 to 35.4 +/- 2.5 kg, p < 0.002) while no changes were seen with placebo. Total body water was not altered significantly either after pioglitazone (from 45.4 +/- 2.3 to 45.6 +/- 2.7 1, p = NS) or placebo. Muscle hydration and extracellular water were unchanged both by pioglitazone and placebo treatments. Conclusions: Six months of pioglitazone treatment in patients with NASH is associated with weight gain that is attributable to an increase in adipose tissue mass and not to water retention. (C) 2007 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. C1 Univ Texas, Hlth Sci Ctr, Dept Med, Diabet Div, San Antonio, TX 78284 USA. Univ Texas, Hlth Sci Ctr, Dept Med, Div Gastroenterol, San Antonio, TX USA. Audie L Murphy Mem Vet Adm Med Ctr, Diabet Div, San Antonio, TX USA. Audie L Murphy Mem Vet Adm Med Ctr, Div Nutr, San Antonio, TX USA. Brooke Army Med Ctr, Div Gastroenterol, Houston, TX USA. CNR, Inst Clin Physiol, Pisa, Italy. RP Cusi, K (reprint author), Univ Texas, Hlth Sci Ctr, Dept Med, Diabet Div, Room 3 308S,7703 Floyd Curl Dr, San Antonio, TX 78284 USA. EM cusi@uthscsa.edu RI Gastaldelli, Amalia/H-3319-2014 OI Gastaldelli, Amalia/0000-0003-2594-1651 FU NCRR NIH HHS [M01-RR-01346] NR 50 TC 41 Z9 41 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-8278 J9 J HEPATOL JI J. Hepatol. PD OCT PY 2007 VL 47 IS 4 BP 565 EP 570 DI 10.1016/j.jhep.2007.04.013 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 218OQ UT WOS:000250025200020 PM 17560678 ER PT J AU Juang, YT Sumibcay, L Tolnay, M Wang, Y Kyttaris, VC Tsokos, GC AF Juang, Yuang-Taung Sumibcay, Laarni Tolnay, Mate Wang, Ying Kyttaris, Vasileios C. Tsokos, George C. TI Elf-1 binds to GGAA elements on the FcR gamma promoter and represses its expression SO JOURNAL OF IMMUNOLOGY LA English DT Article ID RECEPTOR ZETA-CHAIN; T-CELL-RECEPTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; AFFINITY IGE RECEPTOR; GENE; TRANSCRIPTION; ETS; SYK; STIMULATION; SUBUNIT AB The Fe receptor (FcR) gamma-chain has been shown to be up-regulated in T cells when the TCR zeta-chain is decreased. We demonstrate that Elf-1, but not other Ets family transcription factors, bind to a cluster of GGAA sites located within the 200 bp upstream from the transcription initiation site of the FcR gamma promoter. Forced expression of Elf-1 results in the suppression of FcR gamma expression, whereas silencing its expression with small interfering RNA Elf-1 results in increased FcR gamma expression. Elf-1 represents the first transcription factor identified to be involved in the transcriptional regulation of FcR gamma, and cells that fail to express Elf-1, as is the case with human systemic lupus erythematosus T cells, will express FcR gamma-chain. C1 Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA. Ctr Drug Evaluat & Res, Food & Drug Adm, Div Monoclonal Antibodies, Rockville, MD 20857 USA. RP Tsokos, GC (reprint author), Beth Israel Deaconess Med Ctr, 4 Blackfan Circle,HIM-244, Boston, MA 02115 USA. EM gtsokos@bidmc.harvard.edu FU NIAID NIH HHS [R01 AI42269, R01 AI49954] NR 19 TC 9 Z9 12 U1 2 U2 3 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD OCT 1 PY 2007 VL 179 IS 7 BP 4884 EP 4889 PG 6 WC Immunology SC Immunology GA 214QB UT WOS:000249752100067 PM 17878388 ER PT J AU Niu, L Samuelson, LA Kumar, J AF Niu, Langang Samuelson, Lynne A. Kumar, Jayant TI Biosynthesis of liquid crystalline azo-polyesters SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT 7th Technical Symposium in Honor of Sukant K Tripathy CY DEC, 2006 CL Univ Massachusetts Lowell, Lowell, MA HO Univ Massachusetts Lowell DE liquid-crystalline polymers; azobenzene; enzymes ID POLYMERS; STORAGE AB Main-chain thermotropic liquid-crystalline aromatic azobenzene polyesters containing rigid 4,4'-dihydroxyazobenzene mesogens and flexible spacers with varying lengths were synthesized using a chemo-enzymatic method. The enzyme-catalyzed approach is based on immobilized candida antarctica lipase B. The resulting polyesters were characterized by H-1-NMR, C-13-NMR, differential scanning calorimetry (DSC), and polarized light optical microscopy (POM). C1 Univ Massachusetts Lowell, Dept Phys, Ctr Adv Mat, Lowell, MA 01854 USA. Univ Massachusetts Lowell, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. USA, RDECOM, Natick Soldier Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts Lowell, Dept Phys, Ctr Adv Mat, Lowell, MA 01854 USA. EM jayant_kumar@uml.edu NR 14 TC 2 Z9 2 U1 2 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1060-1325 J9 J MACROMOL SCI A JI J. Macromol. Sci. Part A-Pure Appl. Chem. PD OCT-DEC PY 2007 VL 44 IS 10-12 BP 1245 EP 1248 DI 10.1080/10601320701606679 PG 4 WC Polymer Science SC Polymer Science GA 228NU UT WOS:000250737400025 ER PT J AU Cazeca, MJ Li, L Yan, FD Samuelson, LA Kumar, J AF Cazeca, Mario J. Li, Lian Yan, Fadong Samuelson, Lynne A. Kumar, Jayant TI Fabrication of TiO2 grating with composites of azobenzene polymer and TiO2 nanoparticlest SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT 7th Technical Symposium in Honor of Sukant K Tripathy CY DEC, 2006 CL Univ Massachusetts Lowell, Lowell, MA HO Univ Massachusetts Lowell DE SRG structure; azobenzene polymer; TiO2 nanoparticles ID SURFACE-RELIEF GRATINGS; SENSITIZED SOLAR-CELLS; FILMS AB We have used the formation of surface relief gratings (SRG) on azobenzene polymers to manipulate TiO2 nanoparticles and to fabricate TiO2 nanoparticle gratings. Suspensions of an azobenzene polymer (PDO3) and TiO2 were used to spin coat thin films on glass slide substrates. By interfering coherent light from an Argon laser on the surface of the PDO3-TiO2 composite films, SRGs were fabricated. Atomic force microscopic images of the SRGs show TiO2 nanoparticles dispersed throughout the sample, and in particular, at the peaks of the SRG after oxygen plasma treatment. The lateral forces acting on the azobenzene polymer during the SRG fabrication drag the TiO2 nanoparticles. These results indicated that it is feasible to create TiO2 nanoparticle gratings with the composites. C1 Univ Massachusetts Lowell, Ctr Adv Mat, Dept Phys, Lowell, MA 01854 USA. USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA USA. RP Cazeca, MJ (reprint author), Univ Massachusetts Lowell, Ctr Adv Mat, Dept Phys, Lowell, MA 01854 USA. EM mario_cazeca@student.uml.edu NR 13 TC 2 Z9 2 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1060-1325 J9 J MACROMOL SCI A JI J. Macromol. Sci. Part A-Pure Appl. Chem. PD OCT-DEC PY 2007 VL 44 IS 10-12 BP 1329 EP 1332 DI 10.1080/10601320701610762 PG 4 WC Polymer Science SC Polymer Science GA 228NU UT WOS:000250737400039 ER PT J AU Wilantewicz, TE Varner, JR AF Wilantewicz, Trevor E. Varner, James R. TI A recording microindentation instrument for in situ study of crack initiation in glass SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID SODA-LIME GLASS; INDENTATION; HARDNESS AB A recording microindentation instrument equipped with optical observation and acoustic emission detection was built and used to examine, in situ, the crack initiation behavior of a commercial soda-lime-silica based float glass from contact with a Vickers diamond indenter. Indenter motion was provided by a piezoelectric actuator, while a strain gage load cell and capacitance displacement gages simultaneously monitored the indenter load and displacement, respectively, on the glass. It was found that both the maximum load and total indenter contact time influence the initiation behavior. Crack initiation occurred more readily when the total contact time and maximum load were increased. Increasing the maximum load from 0.2 kgf to 4 kgf resulted in the initiation of median-radial cracks on unloading at 6% Fmax up to 50% Fmax, respectively. In contrast, the initiation of lateral cracks was not significantly affected by the total contact time or the maximum load. Examination of the indentation cross-sections beneath 1 and 4 kgf indentation sites revealed well-developed median-radial and lateral crack systems. C1 USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. RP Wilantewicz, TE (reprint author), USA, Res Lab, Impact Phys Branch, ATTN Amsrd Arl WM TD, Aberdeen Proving Ground, MD 21005 USA. EM twilantewicz@comcast.net NR 15 TC 1 Z9 1 U1 2 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD OCT PY 2007 VL 42 IS 20 BP 8529 EP 8536 DI 10.1007/s10853-007-1740-5 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 200LI UT WOS:000248764500022 ER PT J AU Landon, PB Gilleland, CL Synowczynski, J Hirsch, SG Glosser, R AF Landon, Preston B. Gilleland, Cody L. Synowczynski, Jennifer Hirsch, Samuel G. Glosser, R. TI Synthesis of gold nano-wire and nano-dumbbell shaped colloids and AuC60 nano-clusters SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS LA English DT Article; Proceedings Paper CT International Conference on Optical and Optelectronic Properties of Materials and Applications CY JUL 16-21, 2006 CL Darwin, AUSTRALIA SP Charles Darwin Univ, Australian Res Council Nanotechnol Network, Springer, Wiley, OzOpt, Perkin Elmer ID C-60; PARTICLES; CARBON; FILMS AB A technique for the fabrication of colloidal gold nano-wire and nano-dumbbell shaped particles using rod shaped viruses as templates is described. The gold (Au) encapsulation process was accomplished by the precipitation of gold chloride from aqueous solutions. When this process was conducted in the presence Of C-60, small nanocluster composites of AUC(60) formed. C1 Univ Texas, Dept Phys, Richardson, TX 75083 USA. Army Res lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD USA. RP Landon, PB (reprint author), Univ Texas, Dept Phys, Richardson, TX 75083 USA. EM PrestonBLandon@yahoo.com NR 16 TC 2 Z9 2 U1 1 U2 11 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4522 J9 J MATER SCI-MATER EL JI J. Mater. Sci.-Mater. Electron. PD OCT PY 2007 VL 18 SU 1 BP S415 EP S418 DI 10.1007/s10854-007-9228-2 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA 201AG UT WOS:000248803300084 ER PT J AU Lucovsky, G Luning, J Fleming, LB Ulrich, MD Rowe, JE Seo, H Lee, S Lysaght, P Bersuker, G AF Lucovsky, G. Luening, J. Fleming, L. B. Ulrich, M. D. Rowe, J. E. Seo, H. Lee, S. Lysaght, P. Bersuker, G. TI Spectroscopic studies of O-vacancy defects in transition metal oxides SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS LA English DT Article; Proceedings Paper CT International Conference on Optical and Optelectronic Properties of Materials and Applications CY JUL 16-21, 2006 CL Darwin, AUSTRALIA SP Charles Darwin Univ, Australian Res Council Nanotechnol Network, Springer, Wiley, OzOpt, Perkin Elmer AB Dielectrics comprised of nano-crystalline HfO2 in gate stacks with thin SiO2/SiON interfacial transition regions display significant asymmetries with respect to trapping of Si substrate injected holes and electrons. Based on spectroscopic studies, and guided by ab initio theory, electron and hole traps in HfO2 and other transition metal elemental oxides are assigned to O-atom divacancies clustered at internal grain boundaries of nano-crystalline films. Engineering solutions in which grain boundary defects are suppressed include: (i) ultra-thin, < 2 nm, HfO2 fims, 00 chemically phase separated high HfO2 content silicate films, and (iii) non-crystalline Zr/Hf Si oxynitride films. C1 N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. Stanford Synchrotron Res Lab, Stanford, CA USA. Army Res Off, Res Triangle Pk, NC USA. Univ N Carolina, Chapel Hill, NC USA. Sematech, Austin, TX USA. RP Lucovsky, G (reprint author), N Carolina State Univ, Dept Phys, Box 8202, Raleigh, NC 27695 USA. EM lucovsky@ncsu.edu NR 9 TC 0 Z9 0 U1 1 U2 15 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4522 J9 J MATER SCI-MATER EL JI J. Mater. Sci.-Mater. Electron. PD OCT PY 2007 VL 18 SU 1 BP S263 EP S266 DI 10.1007/s10854-007-9192-x PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA 201AG UT WOS:000248803300053 ER PT J AU Keller, CB AF Keller, Christian B. TI The harp and the eagle: Irish-American volunteers and the Union Army, 1861-1865 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Keller, CB (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2007 VL 71 IS 4 BP 1211 EP 1212 PG 2 WC History SC History GA 218MQ UT WOS:000250020000008 ER PT J AU Watson, S AF Watson, Samuel TI Manifest ambition: James K. Polk and civil-military relations during the Mexican war SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2007 VL 71 IS 4 BP 1237 EP 1239 PG 3 WC History SC History GA 218MQ UT WOS:000250020000027 ER PT J AU House, JM AF House, Jonathan M. TI Stalin's keys to victory: The rebirth of the Red Army SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP House, JM (reprint author), USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2007 VL 71 IS 4 BP 1275 EP 1276 PG 2 WC History SC History GA 218MQ UT WOS:000250020000060 ER PT J AU Bourque, SA AF Bourque, Stephen A. TI Pacification in Algeria, 1956-1958 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Bourque, SA (reprint author), USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2007 VL 71 IS 4 BP 1307 EP 1309 PG 3 WC History SC History GA 218MQ UT WOS:000250020000085 ER PT J AU Bourque, SA AF Bourque, Stephen A. TI On "Other War": Lessons from five decades of RAND counterinsurgency research SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Bourque, SA (reprint author), USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2007 VL 71 IS 4 BP 1307 EP 1309 PG 3 WC History SC History GA 218MQ UT WOS:000250020000084 ER PT J AU Kidwell, D AF Kidwell, Deborah TI The A to Z of the Vietnam War SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Kidwell, D (reprint author), USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2007 VL 71 IS 4 BP 1314 EP 1315 PG 2 WC History SC History GA 218MQ UT WOS:000250020000090 ER PT J AU Kautt, W AF Kautt, William TI Defending America: Mililitary culture and the Cold War court-martial SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Kautt, W (reprint author), USA Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2007 VL 71 IS 4 BP 1318 EP 1319 PG 2 WC History SC History GA 218MQ UT WOS:000250020000092 ER PT J AU Hammond, WM AF Hammond, William M. TI Misfortunes of war: Press and public reactions to civilian deaths in wartime SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA, Ctr Mil Hist, Washington, DC 20310 USA. RP Hammond, WM (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2007 VL 71 IS 4 BP 1322 EP 1323 PG 2 WC History SC History GA 218MQ UT WOS:000250020000095 ER PT J AU Somponpun, SJ AF Somponpun, S. J. TI Neuroendocrine regulation of fluid and electrolyte balance by ovarian steroids: Contributions from central oestrogen receptors SO JOURNAL OF NEUROENDOCRINOLOGY LA English DT Article DE subfornical organs; vasopressin; dipsogenic; osmotic; gender; angiotensin ID ANGIOTENSIN-INDUCED DRINKING; HYPOTHALAMO-NEUROHYPOPHYSEAL SYSTEM; VASOPRESSIN GENE-EXPRESSION; MESSENGER-RIBONUCLEIC-ACID; RAT SUPRAOPTIC NUCLEUS; HUMAN OXYTOCIN GENE; FEMALE RATS; SUBFORNICAL ORGAN; SALT APPETITE; MAGNOCELLULAR NEURONS AB Like other hormonally mediated mechanisms, maintenance of body fluid osmolality requires integrated responses from multiple signals at various tissue locales, a large number of which are open to modulation by circulating endocrine factors including the ovarian steroid, oestrogens (E-2). However, the precise mechanism and the site of action of E-2 in regulating fluid osmolality are not properly understood. More importantly, the biological significance of this action is not clear and the physiological circumstances in which this modulation is engaged remain incomplete. The demonstration of oestrogen receptors (ER) in neural tissues that bear no direct relation to reproduction led us to examine and characterise the expression of ER in brain nuclei that are critical for the maintenance of fluid osmolality. In the rat, ER beta is prominently expressed in the vasopressin magnocellular neuroendocrine cells of the hypothalamus, whereas ER alpha is localised extensively in the sensory circumventricular organ neurones in the basal forebrain. These nuclei are the primary brain sites that are engaged in defense of fluid perturbation, thus providing a neuroendocrine basis for oestrogenic influence on body fluid regulation. Plasticity in receptor expression that accompanies fluid disturbances at these central loci suggests the functional importance of the receptors and implicates E-2 as one of the fluid regulating hormones in water homeostasis. C1 Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Somponpun, SJ (reprint author), Tripler Army Med Ctr, Dept Clin Invest, Bldg 40,Rm 216, MCHK-CI CDR,1 Jarrett White Rd, Honolulu, HI 96859 USA. EM suwit.somponpun@amedd.army.mil FU NINDS NIH HHS [R01 NS27975] NR 89 TC 11 Z9 11 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0953-8194 J9 J NEUROENDOCRINOL JI J. Neuroendocrinol. PD OCT PY 2007 VL 19 IS 10 BP 809 EP 818 DI 10.1111/j.1365-2826.2007.01587.x PG 10 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA 210AU UT WOS:000249429900008 PM 17850463 ER PT J AU Neal, CJ Lee, EY Gyorgy, A Ecklund, JM Agoston, DV Ling, GSF AF Neal, Chris J. Lee, Eleanor Y. Gyorgy, Andrea Ecklund, James M. Agoston, Denes V. Ling, Geoffrey S. F. TI Effect of penetrating brain injury on aquaporin-4 expression using a rat model SO JOURNAL OF NEUROTRAUMA LA English DT Article DE brain; edema; injury; water channel ID CENTRAL-NERVOUS-SYSTEM; MOLECULAR-MECHANISMS; REACTIVE ASTROCYTES; ENDOTHELIAL-CELLS; WATER TRANSPORT; UP-REGULATION; HEAD-INJURY; IN-VITRO; EDEMA; HETEROGENEITY AB Cerebral edema (CE) is a frequent and potentially lethal consequence of various neurotraumas, including penetrating brain injury (PBI). Aquaporin-4 (AQP4) water channel is predominantly expressed by astrocytes and plays an important role in regulating water balance in the normal and injured brain. Using a rat model of PBI, we show that AQP4 immunoreactivity was substantially increased in the peri-injury area at both 24 and 72 h after PBI. The increase in AQP4 expression was paralleled by increased GFAP expression. The two proteins were co-expressed by peri-vascular astrocytes, whereas reactive astroglia identified by their stellar morphology did not express AQP4 at either time points after injury. Western analysis confirmed the increase in AQP4 immunoreactivity observed in the injured tissue. The apparent increase in AQP4 immunoreactivity was likely due to de novo AQP4 protein synthesis, as most of the increased AQP4 immunoreactivity was found in the soluble (cytosolic) fraction. Our results demonstrate dynamic spatial and temporal changes in AQP4 expression that contribute to the molecular pathophysiology of PBI. C1 APG, USUHS, Bethesda, MD 20814 USA. Natl Naval Med Ctr, Bethesda, MD USA. Uniformed Serv Univ Hlth Sci, Neurotrauma Lab, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. RP Agoston, DV (reprint author), APG, USUHS, B2036, Bethesda, MD 20814 USA. EM vagoston@usuhs.mil NR 45 TC 20 Z9 24 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD OCT PY 2007 VL 24 IS 10 BP 1609 EP 1617 DI 10.1089/neu.2007.0301 PG 9 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 227HZ UT WOS:000250649100007 PM 17970624 ER PT J AU Downing, J Greig, TW Quattlebaum, MD Valentin, M Heeren, TC Grabenstein, JD AF Downing, Jill Greig, Thomas W. Quattlebaum, Martin D. Valentin, Manuel Heeren, Timothy C. Grabenstein, John D. TI Assessing the safety of anthrax immunization in US Army aircrew members via physical examination SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID REPORTING-SYSTEM VAERS; ADVERSE EVENTS; OPTIC NEURITIS; VACCINE; MILITARY; PERSONNEL; FORCES; HEALTH; SURVEILLANCE; PREGNANCY AB Objective: Anthrax in weaponized form is the bioterrorism agent of most concern. Questions raised about the safety of the anthrax vaccine can be addressed by comparing immunized and unimmunized people in population-based studies. Methods: A retrospective evaluation of data from periodic physical examinations collected on anthrax-immunized and -unimmunized US Army aircrew members between 1998 and 2005 was performed to evaluate the safety of anthrax immunization. Mean changes in variables found on physical examination and laboratory analysis were compared by use of t tests. Multiple linear regression predicted change in outcome from baseline characteristics. Results: We compared 6820 immunized subjects and 4145 unimmunized controls based on US Army aircrew physical examination and screening laboratory tests.'No association between anthrax immunization and a clinically relevant change in a tested physiologic parameter was detected. Conclusions: No attributable risk of anthrax immunization was observed in this group of Army aircrew members. C1 Boston Univ, Sch Publ Hlth, Boston, MA USA. USA, Aeromed Ctr, Ft Rucker, AL USA. USA Med Command, Mil Vaccine Agcy, Falls Church, VA USA. RP Downing, J (reprint author), Boston Univ, Med Ctr, USA Reserve, Cardiovasc Med Sect, 88 E Newton St, Boston, MA 02118 USA. EM jill.downing@bmc.org OI Heeren, Timothy/0000-0001-5643-3559 NR 32 TC 5 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD OCT PY 2007 VL 49 IS 10 BP 1079 EP 1085 DI 10.1097/JOM.0b013e318157d305 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 221ET UT WOS:000250210900007 PM 18000413 ER PT J AU Teyhen, DS Childs, JD Flynn, TW AF Teyhen, Deydre S. Childs, John D. Flynn, Timothy W. TI Rehabilitative ultrasound imaging: When is a picture necessary.? SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material ID LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; 2-YEAR FOLLOW-UP; EXERCISE; PROGRAM; EFFICACY; OUTCOMES C1 Baylor Univ, USA, Doctoral Program Phys Theraphy, San Antonio, TX 76798 USA. Walter Reed Army Med Ctr, Spine Res Ctr, Defense Spinal Cord & Column Injury Ctr, Washington, DC 20307 USA. Regis Univ, Dept Phys Theraphy, Denver, CO USA. RP Teyhen, DS (reprint author), Baylor Univ, USA, Doctoral Program Phys Theraphy, San Antonio, TX 76798 USA. NR 15 TC 6 Z9 6 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD OCT PY 2007 VL 37 IS 10 BP 579 EP 580 PG 2 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 222QJ UT WOS:000250311700001 PM 17970404 ER PT J AU Brenner, AK Gill, NW Buscema, CJ Kiesel, K AF Brenner, Alexander K. Gill, Norman W. Buscema, Christopher J. Kiesel, Kyle TI Improved activation of lumbar multifidus following spinal manipulation: A case report applying rehabilitative ultrasound imaging SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE motor control; reflexogenic; sonography ID LOW-BACK-PAIN; CLINICAL-PREDICTION RULE; SACROILIAC JOINT MANIPULATION; VELOCITY THRUST MANIPULATION; ELECTROMYOGRAPHIC RESPONSES; TRANSVERSUS ABDOMINIS; MUSCLE-CONTRACTION; AUDIBLE POP; RELIABILITY; INDIVIDUALS AB circle dot BACKGROUND: The use of spinal manipulation as a treatment to facilitate neuromuscular control of the paraspinal musculature is not well described in the literature. The use of rehabilitative ultrasound imaging (RUSI) may offer a convenient way to investigate and document possible changes occurring in the lumbar multifidus associated with manipulation intervention. circle dot CASE DESCRIPTION: The patient was a 33-year-old male with a 21-year history of low back pain and left posterior thigh pain who presented with lumbar hypomobility and met a previously published clinical prediction rule for spinal manipulation. During examination, the patient was asked to perform a prone upper extremity lifting task to assess activation in the lumbar multifidus during an automatic task. Through palpation the examiner noted a decreased contraction of the left multifidus between L4-Sl compared to the right. To explore this further, a decision was made to assess the multifidus with RUST, which confirmed the activation deficit noted during palpation. A lumbar regional manipulation was performed with the intention of reducing spinal hypomobility and of assessing changes in multifidus activation. Imaging of the multifidus muscles at the L4-5 and L5-S1 levels were obtained premanipulation, immediately postmanipulation, and 1 day after manipulation. circle dot OUTCOMES: An increased ability to thicken the multifidus during a prone upper extremity lifting task was noted immediately and 1 day after manipulation. Average percent change in thickness at the L4-5 and L5-S1 levels with the prone arm lift was 3.6% premanipulation, 17.2% immediately postmanipulation, and 20.6% approximately 24 hours postmanipulation. Improvements in the thickening of the multifidus muscle during the upper extremity lifting task were greater than 3 standard errors of the measurement. Other changes included immediate palpable improvement in the contraction of the multifidus during the upper extremity lifting task, along with the patient report of increased ease of lifting. circle dot DISCUSSION: In this case report we quantified the short-term influence of spinal manipulation on multifidus muscular activation using RUSI. No cause-and-effect claims can be made; however, the results provide preliminary evidence to suggest that spinal manipulation may influence multifidus muscle function. RUST offers a convenient way to investigate and document these changes. C1 46th Adjutant Gen Battalion, Phys Training & Rehabil Program, Ft Knox, KY USA. Walter Reed Army Med Ctr, Spine Res Ctr, Dept Orthopaed & Rehabil, Washington, DC USA. Baylor Univ, Postprofess Doctoral Program, Orthopaed Manual Phys Therapy, Houston, TX USA. USA, Ctr Hlth, Vicenza, Italy. Univ Evansville, Evansville, IN USA. RP Brenner, AK (reprint author), 403 Chestnut St, Elizabethtown, KY 42701 USA. EM Alexander.brenner@us.army.mil NR 49 TC 12 Z9 12 U1 1 U2 7 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD OCT PY 2007 VL 37 IS 10 BP 613 EP 619 DI 10.2519/jospt.2007.2470 PG 7 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 222QJ UT WOS:000250311700005 PM 17970408 ER PT J AU Henry, SM Teyhen, DS AF Henry, Sharon M. Teyhen, Deydre S. TI Ultrasound imaging as a feedback tool in the rehabilitation of trunk muscle dysfunction for people with low back pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE motor control; multifidus; therapeutic exercise; transverses abdominis ID AUGMENTED INFORMATION; SKILL ACQUISITION; HEALTHY-SUBJECTS; KNOWLEDGE; BIOFEEDBACK; CONTRACTION; EXERCISE; EMG; RETENTION; RECOVERY AB circle dot SYNOPSIS: This commentary provides an overview of the current concepts and the emerging evidence related to rehabilitative ultrasound imaging (RUSI) for biofeedback purposes. Specifically, the role of RUSI to assess improvements in trunk muscle performance and motor learning will be discussed, highlighting the importance of retention and transfer testing to assess motor learning. The use of RUSI as an extrinsic (augmented) feedback tool and its ability to provide both knowledge of performance and knowledge of results information will be defined. An analysis of the limited available literature related to the role of RUST as an augmented feedback tool to enhance motor skill acquisition related to the deep trunk muscles will be provided. Future research directions and priorities are recommended. C1 Univ Vermont, Dept Rehabil & Movement Sci, Burlington, VT 05405 USA. Baylor Univ, USA, Doctoral Program Phys Therapy, Ctr Phys Therapy Res, San Antonio, TX USA. Walter Reed Army Med Ctr, Spine Res Ctr, Defense Spinal Cord Column & Injury Ctr, Washington, DC USA. RP Henry, SM (reprint author), Univ Vermont, Dept Rehabil & Movement Sci, 305 Rowell Bldg,106 Carrigan Dr, Burlington, VT 05405 USA. EM Sharon.Henry@uvm.edu FU NICHD NIH HHS [R01 HD040909] NR 55 TC 28 Z9 33 U1 3 U2 13 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD OCT PY 2007 VL 37 IS 10 BP 627 EP 634 DI 10.2519/jospt.2007.2555 PG 8 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 222QJ UT WOS:000250311700007 PM 17970410 ER PT J AU Springer, BA Gill, NW AF Springer, Barbara A. Gill, Norman W. TI Characterization of lateral abdominal muscle thickness in persons with lower extremity amputations SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE rehabilitative ultrasound imaging; sonography; transtibial; transfemoral; transversus abdominis ID LOW-BACK-PAIN; TRANSVERSUS ABDOMINIS; DRAWING-IN; LIMB; CONTRACTION; STABILIZATION; INDIVIDUALS; EXERCISES; AMPUTEES AB circle dot OBJECTIVES: To describe bilateral thickness of the lateral abdominal muscles at baseline and during an abdominal drawing-in maneuver (ADIM) in individuals with unilateral transtibial (TTA) or transfemoral (TFA) amputations. circle dot BACKGROUND: Although side-to-side symmetry of lateral abdominal muscle thickness has been established in healthy individuals, the degree of symmetry in those with unilateral lower extremity amputations remains unknown. Differences in lateral abdominal muscle thickness may exist based on prior findings of asymmetry and differences measured based on level of amputation in both the size and function of the iliopsoas and back extensor muscles. circle dot METHODS AND MEASURES: Seventy patients (69 males, 1 female) with traumatic unilateral lower extremity amputations (TTA, n = 39; TFA, n = 31) received a rehabilitative ultrasound imaging examination. Absolute thickness of the transversus abdominis (TrA) and the external and internal oblique muscles combined (EO+IO) were assessed bilaterally at baseline and during the ADIM. Symmetry was assessed using relative muscle thickness values at baseline. Percent increase in muscle thickness during the ADIM was used to investigate muscle function. Separate 2-by-2 mixed-model ANOVAs were used to compare both within-group (side of amputation versus nonamputated side) and between-group (TTA versus TFA) differences for thickness and function of the TrA and the EO+IO muscles. circle dot RESULTS: On the side of the amputation, the relative baseline thickness of the EO+IO measurement was greater (P<.05), while the relative baseline thickness of the TrA muscle was smaller (P<.05). But the mean differences side to side were small (1.3%) and unlikely to be clinically significant. Further, there were no differences in baseline muscle thickness between groups for the TrA (P =.95) or the EO+IO (P =.94) muscles. For thickness measurements during the ADIM, the TrA showed no side-to-side (P =.74) or group (P =.07) differences. Similarly, no side-to-side (P=.60) or group (P =.09) differences were found in the EO+IO thickness during the ADIM. circle dot CONCLUSIONS: Despite the limitations of retrospective review, these findings provide an initial reference data set for future studies. Bilateral symmetry of the lateral abdominal wall muscle thicknesses at baseline and during the ADIM for those with unilateral lower extremity amputations is comparable to healthy individuals. Future studies should consider the potential influences of low back pain and gait training on symmetry of muscle thickness and muscle function based on level of amputation. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC USA. USA, Baylor Univ, Postprofess Doctoral Program, Orthopaed Manual Phys Therapy, Houston, TX USA. RP Springer, BA (reprint author), 2 Greenlane Court, Potomac, MD 20854 USA. EM Barbara.Springer@na.amedd.army.mil NR 23 TC 10 Z9 10 U1 0 U2 4 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD OCT PY 2007 VL 37 IS 10 BP 635 EP 643 DI 10.2519/jospt.2007.2532 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 222QJ UT WOS:000250311700008 PM 17970411 ER PT J AU Petersen, MS Belnap, LC Larsen, CWI Farley, LJ AF Petersen, Maj Scott Belnap, LtCol Christina Larsen, Col Wilma I. Farley, LtCol John TI Grading of squamous dysplasia in endocervical curettage specimens - The case for conservative management of mild endocervical dysplasia SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE cervical intraepithelial neoplasia; cervix cancer; cervix dysplasia; curettage; LEEP ID ABNORMAL CERVICAL CYTOLOGY; ELECTROSURGICAL EXCISION PROCEDURE; INTRAEPITHELIAL NEOPLASIA; WOMEN; CONIZATION; PART AB OBJECTIVE: To determine if the severity of dysplasia in a loop electrical excision procedure (LEEP) specimen is different for women with a preoperative endocervical curettage (ECC) positive for mild dysplasia. STUDY DESIGN: Records from a colposcopy clinicfor a 5-year period were reviewed. The subjects were divided into 3 groups: group I, ECC positive for mild dysplasia; group II, mild ectocervical dysplasia; and group III, ECC positive for dysplasia not identified as mild. Outcome variables were a histologic diagnosis on the LEEP specimen and recurrence of dysplasia. Raw data were analyzed. RESULTS: A total of 753 patients underwent a LEEP procedure. One hundred seventy-three (23%) met the inclusion criteria: 37 in group 1, 66 group II and 70 group Ill. Group III had an increased risk of severe dysplasia on LEEP, 68% vs. 25%, over groups I and 11. Patients in group III who had minimally abnormal entry cervical cytology had an increased relative risk of 2.13 for severe dysplasia on LEEP as compared to group I. CONCLUSION: Patients with mild dysplasia on ECC appear to have no greater risk of severe dysplasia on subsequent LEEP specimens than have counterparts with isolated ectocervical mild dysplasia. These patients can be offered conservative follow-up with colposcopy rather than initial definitive therapy. C1 Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. RP Farley, LJ (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd,TAMC, Honolulu, HI 96859 USA. EM john.farley@amedd.army.mil NR 19 TC 0 Z9 0 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD OCT PY 2007 VL 52 IS 10 BP 917 EP 921 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 221RI UT WOS:000250244600010 ER PT J AU Roberts, JR Finger, DR AF Roberts, Jefferson R. Finger, David R. TI Progressive multifocal leukoencephalopathy mimicking central nervous system lupus SO JOURNAL OF RHEUMATOLOGY LA English DT Editorial Material ID ERYTHEMATOSUS C1 Tripler Army Med Ctr, Dept Rheumatol, Honolulu, HI 96701 USA. RP Roberts, JR (reprint author), Tripler Army Med Ctr, Dept Rheumatol, 1 Jarrett White Rd, Honolulu, HI 96701 USA. EM leslieroberts2001@hotmail.com NR 3 TC 7 Z9 7 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD OCT PY 2007 VL 34 IS 10 BP 2119 EP 2120 PG 2 WC Rheumatology SC Rheumatology GA 217OB UT WOS:000249956100030 PM 17924609 ER PT J AU Coutermarsh, B AF Coutermarsh, Barry TI Velocity effect of vehicle rolling resistance in sand SO JOURNAL OF TERRAMECHANICS LA English DT Article DE rolling resistance; vehicle rolling resistance; aircraft rolling resistance; vehicle mobility in sand AB Vehicle rolling resistance is important to vehicle and aircraft ground movement in loose soil and sand conditions, especially in military operations. Off-road rolling resistance measurements have been taken at relatively low velocities, 2.1-4.6 m/s (meters per second) (715 ft/s) (4-9 knots), which has precluded studying any potential velocity effect on rolling resistance. With the emergence of aircraft designed to be used on unimproved soil runways and the military's proposed new vehicles, especially the lighter-weight, 23-500-kg (50-1 100-lbs) robotics, capable of high-velocity off-road movement, it is important that the rolling resistance be measured at velocities closer to the expected operating conditions. This paper presents data from rubber tire rolling resistance measurements in three depths of uniform-density dry sand at velocities from 2.1 up to 18 m/s (7-58 ft/s) (4-34 knots) and three load ranges from 4534 to 10,266 N (10202308 lbs). In dry sand the rolling resistance increases with velocity until the tire starts to "plane," where it levels off or decreases and it is modified by load. Limited past work in this area is presented along with some existing analytical descriptions of rolling resistance versus velocity. Limited agreement between the published equations and the test data, along with contradictory published results, indicate that additional work on this topic is needed. (c) 2007 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 US Army Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Coutermarsh, B (reprint author), US Army Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Barry.A.Coutermarsh@erdc.usace.army.mil NR 12 TC 15 Z9 15 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD OCT PY 2007 VL 44 IS 4 BP 275 EP 291 DI 10.1016/j.jterra.2007.03.001 PG 17 WC Engineering, Environmental SC Engineering GA 236WF UT WOS:000251333400001 ER PT J AU Ficke, JR Pollak, AN AF Ficke, James R. Pollak, Andrew N. TI Introduction - Extremity war injuries: Development of clinical treatment principles SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Editorial Material C1 Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. Univ Maryland, Sch Med, RAC Shock Trauma Ctr, Baltimore, MD 21201 USA. RP Ficke, JR (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1067-151X EI 1940-5480 J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD OCT PY 2007 VL 15 IS 10 BP 588 EP 589 PG 2 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 238BP UT WOS:000251422600002 PM 17916781 ER PT J AU Ficke, JR Pollak, AN AF Ficke, James R. Pollak, Andrew N. TI Extremity war injuries: Development of clinical treatment principles SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Editorial Material ID HEMORRHAGE CONTROL; EXTERNAL FIXATION; TOURNIQUET USE; BATTLEFIELD AB The AAOS/OTA Extremity War Injuries: Development of Clinical Treatment Principles symposium, held in January 2007, was a follow-up to the first Extremity War Injuries symposium held a year earlier. Discussion focused on four specific areas: prehospital management of extremity wounds, initial debridement, early stabilization, and postoperative wound management during air evacuation. Liberal emergency use of field tourniquets likely is contributing to lower overall mortality and is associated with very low rates of complications. Additional tools for extremity hemorrhage control, such as chitosan-based patches and granular zeolite hemostat, were postulated to be effective. Consensus opinion was that necrotic, devitalized, and contaminated tissue must be removed although objective assessment of completeness of initial debridement is difficult. Definitive open reduction and internal fixation for US and Coalition forces in the theater of operations should be limited to fracture patterns associated with significant perceived risk of delay in treatment. Finally, primary skin closure should be avoided in theater. In addition, because of the time and complications involved in transporting patients to level 4 care facilities, surgeons should consider release of compartments prior to patient transport whenever significant perceived potential for compartment syndrome is present. C1 Univ Maryland, Sch Med, Div Orthopaed Traumatol, Baltimore, MD 21201 USA. R Adams Cowley Shock Trauma Ctr, Baltimore, MD USA. Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Pollak, AN (reprint author), Univ Maryland, Sch Med, Div Orthopaed Traumatol, Suite T3R54,22 S Greene St, Baltimore, MD 21201 USA. NR 14 TC 20 Z9 22 U1 0 U2 4 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD OCT PY 2007 VL 15 IS 10 BP 590 EP 595 PG 6 WC Orthopedics SC Orthopedics GA 238BP UT WOS:000251422600003 PM 17916782 ER PT J AU Armstrong, LE AF Armstrong, Lawrence E. TI Scientific consensus statement regarding the importance of hydration and total water intake for health and disease 29 November 2006 Washington, DC USA SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Editorial Material AB Water is the largest constituent of the human body. Body water is lost continuously; the amount lost is variable and is influenced by age, body size, level of physical activity, health status, and environmental conditions. Water losses must be replaced via dietary sources of water, which include beverages and foods. For example, in the U.S. and Canada, the Institute of Medicine's reference values for water are based on data showing that approximately 80% of total water intake is derived from drinking water and other beverages. For individuals aged 19 years and older, this equates to an average daily fluid intake (drinking water and other beverages) of 3.0 L for males and 2.2 L for females. Other regions and countries may have different intakes. C1 Univ Connecticut, Storrs, CT 06269 USA. Beverage Inst Hlth & Wellness, Atlanta, GA USA. Nutr Impact LLC, Battle Creek, MI USA. Healthcare Creat, Columbus, OH USA. Ctr Human Nutr, Omaha, NE USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. E Carolina Univ, Greenville, NC USA. Univ Tubingen, Tubingen, Germany. US ARIEM, Natick, MA USA. Res Inst Child Nutr, Dortmund, Germany. Univ Loughborough, Loughborough, Leics, England. Gatorade Sports Sci Inst, Barrington, IL USA. Tufts Univ, Boston, MA 02111 USA. Iowa State Univ, Ames, IA USA. RP Armstrong, LE (reprint author), Univ Connecticut, Storrs, CT 06269 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER COLLEGE NUTRITION PI CLEARWATER PA 300 SOUTH DUNCAN AVENUE, STE 225, CLEARWATER, FL 33755 USA SN 0731-5724 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD OCT PY 2007 VL 26 IS 5 SU S BP 531S EP 532S PG 2 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 225GY UT WOS:000250506300003 ER PT J AU Lieberman, HR AF Lieberman, Harris R. TI Hydration and cognition: A critical review and recommendations for future research SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Article; Proceedings Paper CT ILSI North American Conference on Hydration and Health Promotion CY NOV 29-30, 2006 CL Washington, DC SP Int Life Sci Inst, N Amer Tech Comm Hydrat DE cognitive performance; mood; fatigue; dehydration; environment; heat; exercise ID HEAT-STRESS; MENTAL PERFORMANCE; MILD DEHYDRATION; CAFFEINE; SLEEP; MOOD AB The limited literature on the effects of dehydration on human cognitive function is contradictory and inconsistent. Although it has been suggested that decrementsin cognitive performance are present in the range of a 2 to 3% reduction in body weight, several dose-response studies indicate dehydration levels of 1% may adversely affect cognitive performance. When a 2% or more reduction in body weight is induced by heat and exercise exposure, decrements in visual-motor tracking, short-term memory and attention are reported, but not all studies find behavioral effects in this range. Future research should be conducted using dose-response designs and state-of-the-art behavioral methods to determine the lowest levels of dehydration that produce substantive effects on cognitive performance and mood. Confounding factors, such as caffeine intake and the methods used to produce dehydration, need to be considered in the design and conduct of such studies. Inclusion of a positive control condition, such as alcohol intake, a hypnotic drug, or other treatments known to produce adverse changes in cognitive performance should be included in such studies. To the extent possible, efforts to blind both volunteers and investigators should be an important consideration in study design. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil NR 23 TC 64 Z9 69 U1 2 U2 26 PU AMER COLLEGE NUTRITION PI CLEARWATER PA 300 SOUTH DUNCAN AVENUE, STE 225, CLEARWATER, FL 33755 USA SN 0731-5724 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD OCT PY 2007 VL 26 IS 5 SU S BP 555S EP 561S PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 225GY UT WOS:000250506300008 PM 17921465 ER PT J AU Kenefick, RW Sawka, MN AF Kenefick, Robert W. Sawka, Michael N. TI Hydration at the work site SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Article; Proceedings Paper CT ILSI North American Conference on Hydration and Health Promotion CY NOV 29-30, 2006 CL Washington, DC SP Int Life Sci Inst, N Amer Tech Comm Hydrat DE hydration; health; occupational safety; fluid replacement ID EXERCISE-HEAT STRESS; INDUCED DEHYDRATION; BLOOD-VOLUME; FLUID REPLACEMENT; BODY-FLUIDS; WATER; PERFORMANCE; HYPOHYDRATION; THERMOREGULATION; HUMANS AB When performing physical work, sweat output often exceeds water intake, producing a body water deficit or dehydration. Specific to the work place, dehydration can adversely affect worker productivity, safety, and morale. Legislative bodies in North America such as the Occupational Safety and Health Administration (OSHA) and the American Conference of Governmental Industrial Hygienists (ACGIH) recommend replacing fluids frequently when exposed to heat stress, such as one cup (250 ml) every 20 minutes when working in warm environments. However, the majority of legislative guidelines provide vague guidance and none take into account the effects of work intensity, specific environments, or protective clothing. Improved occupational guidelines for fluid and electrolyte replacement during hot weather occupational activities should be developed to include recommendations for fluid consumption before, during, and after work. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, 42 Kansas St, Natick, MA 01760 USA. EM Robert.Kenefick@us.army.mil NR 49 TC 22 Z9 23 U1 1 U2 10 PU AMER COLLEGE NUTRITION PI CLEARWATER PA 300 SOUTH DUNCAN AVENUE, STE 225, CLEARWATER, FL 33755 USA SN 0731-5724 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD OCT PY 2007 VL 26 IS 5 SU S BP 597S EP 603S PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 225GY UT WOS:000250506300015 PM 17921472 ER PT J AU Schreiber, MA Perkins, J Kiraly, L Underwood, S Wade, C Holcomb, JB AF Schreiber, Martin A. Perkins, Jeremy Kiraly, Laszlo Underwood, Samantha Wade, Charles Holcomb, John B. TI Early predictors of massive transfusion in combat casualties SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID TRAUMA PATIENTS; BLOOD-TRANSFUSION; BASE DEFICIT; HEAD-INJURY; COAGULOPATHY; RESUSCITATION; COAGULATION; MORTALITY; PATIENT; HYPOTHERMIA AB Background: An early predictive model for massive transfusion (MT) is critical for management of combat casualties because of limited blood product availability, component preparation, and the time necessary to mobilize fresh whole blood donors. The purpose of this study was to determine which variables, available early after injury, are associated with MT We hypothesized that International Normalized Ratio and penetrating mechanism would be predictive. Study Design: We performed a retrospective cohort analysis in two combat support hospitals in Iraq. Patients who required MT were compared with patients who did not. Eight potentially predictive variables were subjected to univariate analysis. Variables associated with need for MT were then subjected to stepwise logistic regression. Results: Two hundred forty-seven patients required MT and 311 did not. Mean Injury Severity Score was 22 in the MT group and 5 in the non-MT group (p < 0.001). Patients in the MT group received 17.9 U stored RBCs and 2.0 U fresh whole blood, versus 1.1 U RBCs and 0.2 U whole blood in the non-MT group (p < 0.001). Mortality was 39% in the MT group and 1% in the non-MT group (p < 0.001). Variables that independently predicted the need for MT were: hemoglobin <= 11 g/dL, International Normalized Ratio > 1.5, and a penetrating mechanism. The area under the receiver operator characteristic curve was 0.804 and Hosmer-Lemeshow goodness-of-fit test was 0.98. Conclusion: MT after combat injury is associated with high mortality. Simple variables available early after admission allow accurate prediction of MT. C1 Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97239 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Schreiber, MA (reprint author), Oregon Hlth & Sci Univ, Dept Surg, 3181 SW Sam Jackson Pk Rd,L611, Portland, OR 97239 USA. EM schreibm@ohsu.edu NR 25 TC 128 Z9 130 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2007 VL 205 IS 4 BP 541 EP 545 DI 10.1016/j.jamcollsurg.2007.05.007 PG 5 WC Surgery SC Surgery GA 222QP UT WOS:000250312300003 PM 17903727 ER PT J AU Datta, A Nixon, M Chopra, I AF Datta, Anubhav Nixon, Mark Chopra, Inderjit TI Review of rotor loads prediction with the emergence of rotorcraft CFD SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 31st European Rotorcraft Forum CY SEP 13-15, 2005 CL Florence, ITALY ID ESSENTIALLY NONOSCILLATORY SCHEMES; ROTARY-WING AEROELASTICITY; GEOMETRIC CONSERVATION LAW; COMPRESSIBLE DYNAMIC STALL; FINITE-DIFFERENCE SCHEMES; TRANSONIC POTENTIAL FLOW; LARGE-EDDY SIMULATIONS; TIME-DEPENDENT RANS; FREE-WAKE ANALYSIS; HELICOPTER ROTOR AB This paper reviews the state of the art in helicopter rotor loads prediction with the emergence of computational fluid dynamics (CFD) and computational structural dynamics (CSD) coupling. The focus is on steady level flight, where most of the current CFD/CSD analyses are being applied. The application of CFD to rotorcraft problems has evolved, over the period 1990-2005, as a viable means to improve the aerodynamic modeling used in rotorcraft comprehensive analyses (CA). It has the potential to meet the ultimate objective of a coupled rotor-fuselage analysis that can predict loads and vibration accurately at all critical flight conditions without semi-empirical inputs. The paper begins by identifying three critical level flight conditions. These are useful to isolate the key aerodynamic and structural dynamic mechanisms. It is followed by a review of the capabilities and limitations of current CFD analyses in representing the key aerodynamic mechanisms: three-dimensional airloads and wake, dynamic stall, unsteady transonic effects near the tip, and fuselage aerodynamic effects. The structural dynamic methods are then briefly reviewed. Finally, the recent rotorcraft CFD/CSD coupling methods are described and evaluated on the basis of their loads prediction capability. The emphasis is on the fundamental aeroelastic mechanisms which determine the critical rotor loads, and with which the accuracy and efficiency of all CFD/CSD coupled analyses should be assessed. C1 Univ Maryland, Alfred Gessow Rotorcraft Ctr, Dept Aerosp Engn, College Pk, MD 20742 USA. USA, Res Lab, Langley Res Ctr, Hampton, VA USA. RP Datta, A (reprint author), Univ Maryland, Alfred Gessow Rotorcraft Ctr, Dept Aerosp Engn, College Pk, MD 20742 USA. EM datta@umd.edu NR 238 TC 26 Z9 28 U1 0 U2 8 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 2007 VL 52 IS 4 BP 287 EP 317 PG 31 WC Engineering, Aerospace SC Engineering GA 227GS UT WOS:000250645800001 ER PT J AU Taylor, LW Wilborn, CD Harvey, T Wismann, J Willoughby, DS AF Taylor, Lemuel W. Wilborn, Colin D. Harvey, Travis Wismann, Jennifer Willoughby, Darryn S. TI Acute effects of ingesting Java Fit (TM) energy extreme functional coffee on resting energy expenditure and hemodynamic responses in male and female coffee drinkers SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Article AB Background: The purpose of this study was to examine the effects of a functional coffee beverage containing additional caffeine, green tea extracts, niacin and garcinia cambogia to regular coffee to determine the effects on resting energy expenditure (REE) and hemodynamic variables. Methods: Subjects included five male (26 +/- 2.1 y, 97.16 +/- 10.05 kg, 183.89 +/- 6.60 cm) and five female (28.8 +/- 5.3 y, 142.2 +/- 12.6 lbs) regular coffee drinkers. Subjects fasted for 10 hours and were assessed for 1 hour prior (PRE) and 3 hours following 1.5 cups of coffee ingestion [JavaFit (TM) Energy Extreme (JF) similar to 400 mg total caffeine; Folgers (F) similar to 200 mg total caffeine] in a double-blind, crossover design. REE, resting heart rate (RHR), and systolic (SBP) and diastolic (DBP) blood pressure was assessed at PRE and 1, 2, and 3-hours post coffee ingestion. Data were analyzed by three-factor repeated measures ANOVA (p < 0.05). Results: JF trial resulted in a significant main effect for REE (p < 0.01), SBP (p < 0.01), RER (p < 0.01), and VO(2) (p < 0.01) compared to F, with no difference between trials on the RHR and DBP variables. A significant interaction for trial and time point (p < 0.05) was observed for the variable REE. The JF trial resulted in a significant overall mean increase in REE of 14.4% (males = 12.1%, females = 17.9%) over the observation period (p < 0.05), while the F trial produced an overall decrease in REE of 5.7%. SBP was significantly higher in the JF trial; however, there was no significant increase from PRE to 3-hours post. Conclusion: Results from this study suggest that JavaFit (TM) Energy Extreme coffee is more effective than Folgers regular caffeinated coffee at increasing REE in regular coffee drinkers for up to 3 hours following ingestion without any adverse hemodynamic effects. C1 [Wismann, Jennifer; Willoughby, Darryn S.] Baylor Univ, Exercise & Biochem Nutr Lab, Ctr Exercise Nutr & Prevent Hlth Res, Dept Hlth Human Performance & Recreat, Waco, TX 76798 USA. [Taylor, Lemuel W.] Univ W Florida, Exercise Biochem Lab, Dept Hlth Leisure & Exercise Sci, Pensacola, FL 32514 USA. [Wilborn, Colin D.] Univ Mary Hardin Baylor, Dept Exercise & Sport Sci, Belton, TX USA. [Harvey, Travis] US Mil Acad, Dept Phys Educ, Ctr Phys Dev Excellence, West Point, NY 10996 USA. RP Willoughby, DS (reprint author), Baylor Univ, Exercise & Biochem Nutr Lab, Ctr Exercise Nutr & Prevent Hlth Res, Dept Hlth Human Performance & Recreat, Waco, TX 76798 USA. EM ltayloriv@uwf.edu; cwilborn@umhb.edu; Travis.Harvey@usma.edu; Jen_Wismann@baylor.edu; Darryn_Willoughby@baylor.edu FU Javalution Coffee Company (Fort Lauderdale, FL) FX We would like to thank the subjects that participated in this study as well as all laboratory assistants who assisted with data collection and analysis. We would also like to thank Dr. Richard Kreider and the Exercise and Sport Nutrition Laboratory at Baylor University for use of the metabolic carts. This study was funded by Javalution Coffee Company (Fort Lauderdale, FL) through an unrestricted research grant to Baylor University. Written consent for publication was obtained from all subjects. All researchers involved independently collected, analyzed, and interpreted the results from this study and have no financial interests concerning the outcome of this investigation. NR 37 TC 10 Z9 11 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD OCT PY 2007 VL 4 AR 10 DI 10.1186/1550-2783-4-10 PG 9 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA V17ZE UT WOS:000207974300002 PM 17919327 ER PT J AU Borgman, MA Spinella, PC Perkins, JG Grathwohl, KW Repine, T Beekley, AC Sebesta, J Jenkins, D Wade, CE Holcomb, JB AF Borgman, Matthew A. Spinella, Philip C. Perkins, Jeremy G. Grathwohl, Kurt W. Repine, Thomas Beekley, Alec C. Sebesta, James Jenkins, Donald Wade, Charles E. Holcomb, John B. TI The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE blood components; fresh frozen plasma; trauma; coagulopathy ID FRESH-FROZEN PLASMA; ACUTE TRAUMATIC COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; INDEPENDENT RISK-FACTOR; CRITICALLY-ILL PATIENTS; MULTIPLE ORGAN FAILURE; FLUID RESUSCITATION; CELL TRANSFUSION; WHOLE-BLOOD; COAGULATION AB Background: Patients with severe traumatic injuries often present with coagulopathy and require massive transfusion. The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units. Methods: We performed a retrospective chart review of 246 patients at a US Army combat support hospital, each of who received a massive transfusion ( >= 10 units of RBCs in 24 hours). Three groups of patients were constructed according to the plasma to RBC ratio transfused during massive transfusion. Mortality rates and the cause of death were compared among groups. Results: For the low ratio group the plasma to RBC median ratio was 1:8 (interquartile range, 0:12-1:5),. for the medium ratio group, 1:2.5 (interquartile range, 1:3.0-1:2.3), and for the high ratio group, 1:1.4 (interquartile range, 1:1.7-1:1.2) (p < 0.001). Median Injury Severity Score (ISS) was 18 for all groups (interquartile range, 14-25). For low, medium, and high plasma to RBC ratios, overall mortality rates were 65%, 34%, and 19%, (p < 0.001); and hemorrhage mortality rates were 92.5%, 78%, and 37%, respectively, (p < 0.001). Upon logistic regression, plasma to RBC ratio was independently associated with survival (odds ratio 8.6, 95% confidence interval 2.1-35.2). Conclusions: in patients with combat-related trauma requiring massive transfusion, a high 1:1.4 plasma to RBC ratio is independently associated with improved survival to hospital discharge, primarily by decreasing death from hemorrhage. For practical purposes, massive transfusion protocols should utilize a 1:1 ratio of plasma to RBCs for all patients who are hypocoagulable with traumatic injuries. C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Borgman, MA (reprint author), 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM mattborgman@hotmail.com RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 67 TC 700 Z9 739 U1 2 U2 33 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2007 VL 63 IS 4 BP 805 EP 813 DI 10.1097/TA.0b013e3181271ba3 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 219XL UT WOS:000250121400014 PM 18090009 ER PT J AU Stansbury, LG Branstetter, JG Lalliss, SJ AF Stansbury, Lynn G. Branstetter, Joanna G. Lalliss, Steven J. TI Amputation in military trauma surgery SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE amputation; military history; battlefield trauma ID INJURIES; REPAIR; CARE; WAR AB Background: Major limb amputations are among the most debilitating wounds sustained by those who survive a combat injury and these injuries leave a lasting impression with the public. This article will review the history of major limb amputation in military trauma surgery. Methods: Review of published historic and modern battle casualty information was undertaken in the collections of the medical library of the National Naval Medical Center and the National Library of Medicine, both in Bethesda, Maryland, and the University of Maryland Health Sciences Center in Baltimore, Maryland. Results: The potential utility of major limb amputation as a life-saving surgical intervention for compound fractures and other devastating limb injuries has been recognized through much of written human history. However, the advent of gunpowder onto the battlefields of Europe in the 14th century forced surgeons to solve the problems of, first, hemorrhage and then, as casualties survived the initial surgery, sepsis for amputation to actually improve outcomes. In the latter half of the 20th century, rapid evacuation from the battlefield and successful neurovascular repair has reduced the need for major limb amputations essentially for those required by insurmountable tissue loss. Conclusions: Major limb amputation remains a fearsome outcome of limb injury. However, during the last 500 years, military trauma surgeons have solved the problems of bleeding, infection, and neurovascular repair after major limb injury such that amputation rates even during times of active military conflict are at historic lows. C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Extrem Soft Tissue, Ft Sam Houston, TX USA. Dept Orthopaed & Rehabil, Ft Sam Houston, TX USA. RP Branstetter, JG (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM branstetterj@gmail.com NR 48 TC 21 Z9 22 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2007 VL 63 IS 4 BP 940 EP 944 DI 10.1097/TA.0b013e31814934d8 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 219XL UT WOS:000250121400039 PM 18090027 ER PT J AU Tausch, TJ Cavalcanti, AG Soderdahl, DW Favorito, L Rabelo, P Morey, AF AF Tausch, Timothy J. Cavalcanti, Andre G. Soderdahl, Douglas W. Favorito, Luciano Rabelo, Paulo Morey, Allen F. TI Gunshot wound injuries of the prostate and posterior urethra: Reconstructive armamentarium SO JOURNAL OF UROLOGY LA English DT Article DE wounds; penetrating; prostate; urethra ID PRIMARY REALIGNMENT AB Purpose: Descriptions of posterior urethral penetrating injuries are rare in the literature and their management is poorly described. We reviewed the medical records of 19 men who sustained posterior urethral gunshot wounds and report our experience with various treatment options. Materials and Methods: We retrospectively reviewed the records of 19 men (mean age 27 years) who sustained posterior urethral gunshot wound injuries confirmed by retrograde urethrography and/or exploratory laparotomy. Treatment options included immediate primary repair in 2 patients, delayed reconstruction in 15 and complete prostatectomy in 2. Outcomes were described by flow rates and lower urinary tract symptoms. Results: Of 15 patients who underwent delayed repair 13 (86.6%) demonstrated normal flow rates and lack of lower urinary tract symptoms. The 2 remaining patients experienced obliterative stricture recurrences and were treated with open surgery. Both patients who underwent immediate primary repair had normal flow rates. Of the 2 men who underwent immediate prostatectomy 1 had moderate incontinence requiring absorbent pad use and the other was lost to followup after he was discharged home with a suprapubic catheter in place. Conclusions: An initial management strategy based on the principles of maximizing urinary catheter drainage, with direct retropubic repair/urethral realignment when possible and definitive perineal reconstruction when necessary, appears to provide acceptable outcomes while minimizing the number of subsequent interventions required. C1 Brooke Army Med Ctr, Urol Serv, Ft Sam Houston, TX 78234 USA. Hosp Municipal Souza Aguiar, Dept Urol, Rio De Janeiro, Brazil. RP Morey, AF (reprint author), Brooke Army Med Ctr, Urol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM allen.morey@amedd.army.mil RI favorito, luciano/L-6628-2014 NR 9 TC 6 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 2007 VL 178 IS 4 BP 1346 EP 1348 DI 10.1016/j.juro.2007.05.141 PN 1 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 212BI UT WOS:000249568200055 PM 17706720 ER PT J AU Bartone, PT Snook, SA Forsythe, GB Lewis, P Bullis, RC AF Bartone, Paul T. Snook, Scott A. Forsythe, George B. Lewis, Philip Bullis, Richard C. TI Psychosocial development and leader performance of military officer cadets SO LEADERSHIP QUARTERLY LA English DT Article DE psychosocial development; leader development; kegan; military AB Efforts to educate and develop future military officers aim to produce highly competent, ethical and effective leaders to serve the nation. But while there is general agreement about desired outcomes, the underlying developmental processes associated with these outcomes are not well understood. How do we grow such leaders? This paper reports on a longitudinal study of West Point college students over four years, addressing three questions: (1) do military officer-cadets grow or change in their basic level of psychosocial development [Kegan, R. (1982). The Evolving Self- Problem and Process in Human Development. Cambridge, MA: Harvard University Press.], (2) is the level of psychosocial development related to performance as leaders, and (3) do activities in high school predict later psychosocial development? Two groups of cadets were studied from their freshman or sophomore year to their senior year at the academy. Results show significant positive developmental growth over time for 47% of study participants, with most of this growth occurring from sophomore to senior year. Furthermore, psychosocial development predicts several peer, subordinate and supervisor ratings of cadet performance as leaders during the upperclass junior and senior) years, a time when cadets take on substantial leadership roles. In addition, early performance ratings by high school teachers, as well as active participation in high school extracurricular activities both predict psychosocial development levels for freshman and sophomores. These findings lend support to Kegan's theoretical model, and suggest that greater attention be paid to these basic processes of human psychosocial development that can influence leader performance in important ways. (C) 2007 Elsevier Inc. All rights reserved. C1 Natl Def Univ, Ind Coll Armed Forces, Dept Leadership & Informat Strategy, Washington, DC 20319 USA. Harvard Univ, Sch Business, Boston, MA 02163 USA. Westminster Coll, Fulton, MI USA. Auburn Univ, Auburn, AL 36849 USA. USA, War Coll, Carlisle, PA USA. RP Bartone, PT (reprint author), Natl Def Univ, Ind Coll Armed Forces, Dept Leadership & Informat Strategy, Washington, DC 20319 USA. EM bartonep@ndu.edu OI Bartone, Paul/0000-0002-5767-0086 NR 41 TC 23 Z9 23 U1 4 U2 14 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 J9 LEADERSHIP QUART JI Leadersh. Q. PD OCT PY 2007 VL 18 IS 5 BP 490 EP 504 DI 10.1016/j.leaqua.2007.07.008 PG 15 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 219JE UT WOS:000250079900005 ER PT J AU Ashley, PR Temmen, MG Diffey, WM Sanghadasa, M Bramson, MD AF Ashley, P. R. Temmen, M. G. Diffey, W. M. Sanghadasa, M. Bramson, M. D. TI Development of components for IFOG-based inertial measurement units using polymer waveguide fabrication technologies SO MEASUREMENT SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 18th International Conference on Optical Fibre Sensors CY OCT, 2006 CL Cancun, MEXICO DE gyroscopes; electro-optic polymers; polymer waveguides; nonlinear optics; integrated optics; optical devices AB Active and passive polymer materials have been successfully used in the development of highly accurate, compact and low cost guided- wave components: an optical transceiver and a phase modulator, for inertial measurement units ( IMUs) based on the interferometric fibre optic gyroscope ( IFOG) technology for precision guidance in navigation systems. High performance and low noise transceivers with high optical power and good spectral quality were fabricated using a silicon- bench architecture. Low loss phase modulators with low halfwave drive voltage ( V-pi) have been fabricated with a backscatter compensated design using polarizing waveguides consisting of CLD- and FTC- type high performance electro-optic (E-O) chromophores. Gyro bias stability of less than 0.02 degrees h(-1) has been demonstrated with these guided- wave components. C1 US Army RDECOM, Redstone Arsenal, AL 35898 USA. AEgis Technol Grp, Huntsville, AL 35806 USA. US Navy NAWCWD, China Lake, CA 93555 USA. RP Ashley, PR (reprint author), US Army RDECOM, Redstone Arsenal, AL 35898 USA. EM Mohan.Sanghadasa@us.army.mil NR 15 TC 4 Z9 5 U1 0 U2 7 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-0233 EI 1361-6501 J9 MEAS SCI TECHNOL JI Meas. Sci. Technol. PD OCT PY 2007 VL 18 IS 10 BP 3165 EP 3170 DI 10.1088/0957-0233/18/10/S18 PG 6 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 217YB UT WOS:000249982100019 ER PT J AU Martin, PJ Russell, K Sodhi, RS AF Martin, Peter J. Russell, Kevin Sodhi, Raj S. TI On mechanism design optimization for motion generation SO MECHANISM AND MACHINE THEORY LA English DT Article ID RIGID-BODY GUIDANCE; PLANAR MECHANISMS; DIMENSIONAL SYNTHESIS; LINKAGES AB A set of Burmester curves can represent an infinite number of planar four-bar motion generator solutions for a given series of prescribed rigid-body poses. Unfortunately, given such a vast number of possible mechanical solutions, it is dif ficult for designers to arbitrarily select a Burmester curve solution that ensures full link rotatability, produces feasible transmission angles and is as compact as possible. This work presents an algorithm for selecting planar four-bar motion generators with respect to Grashof conditions, transmission angle conditions and having the minimal perimeter value. This algorithm has been codified into MathCAD for enhanced analysis capabilities and ease of use. The example in this work demonstrates the synthesis of a compact planar, four-bar crank rocker motion generator with feasible transmission angles. (c) 2006 Elsevier Ltd. All rights reserved. C1 [Martin, Peter J.; Russell, Kevin] US Army Res Dev & Engn Ctr, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. [Sodhi, Raj S.] New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. RP Russell, K (reprint author), US Army Res Dev & Engn Ctr, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. EM kevruss@pica.army.mil NR 20 TC 10 Z9 14 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0094-114X J9 MECH MACH THEORY JI Mech. Mach. Theory PD OCT PY 2007 VL 42 IS 10 BP 1251 EP 1263 DI 10.1016/j.mechmachtheory.2006.11.009 PG 13 WC Engineering, Mechanical SC Engineering GA 267DJ UT WOS:000253489400001 ER PT J AU Stojadinovic, A Henry, LR Peoples, GE Mittendorf, EA Lenington, S Nissan, A Shriver, CD AF Stojadinovic, Alexander Henry, Leonard R. Peoples, George E. Mittendorf, Elizabeth A. Lenington, Sarah Nissan, Avirarn Shriver, Craig D. TI Satisfaction with breast cancer screening and future screening participation SO MEDICAL SCIENCE MONITOR LA English DT Article DE breast cancer screening; cancer screening compliance ID YOUNG-WOMEN; FAMILY-HISTORY; MAMMOGRAPHY; RISK; GUIDELINES; ADHERENCE; EXPERIENCES; BELIEFS; ACCESS; HEALTH AB Background: To measure satisfaction with an investigational breast cancer risk screening technique, [ empidance scanning (EIS) ] and to investigate the relationship between satisfaction and willingness to return for follow-up examination one year later. Material/Methods: 2727 women volunteers (age 18-15 years, miliatry healthcare beneficiaries) underwent an EIS exam (reported as "negative" (average risk) or "positive" (high risk)); then they filled out a questionnaire assessing satisfaction with the procedure. One year later, woman were invited for the following screening. Results: Satisfaction score was significantly related to EIS exam result (higher for women with negative exams), importance assigned to breast cancer screening, and family history of breast cancer. However, satisfaction was not related to scheduling a visit the following year for the follow-up examination. The only satisfaction component predicting return was satisfaction with exam reporting for participants with positive exam results. Return was related positively to age and race/ethnicity; older women and Hispanic women more likely, while African American women were less likely, to return for follow-up. Conclusions: Factors affecting breast cancer screening participation among younger women are diverse and complex. Further study and delineation of such factors is necessary to understand how best tailor breast cancer education program in young women. C1 Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Natl Naval Med Ctr, Bethesda, MD USA. Brooke Army Med Ctr, Surg Oncol, Ft Sam Houston, TX USA. MD Anderson Canc Ctr, Houston, TX USA. SGL Biomed Consulting LLC, Ringwood, NJ USA. Hadassah Univ Hosp, Jerusalem, Israel. Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave,Suite 5C27A,NW, Washington, DC 20307 USA. EM alexander.stojadinovic@na.amedd.army.mil NR 33 TC 4 Z9 5 U1 1 U2 3 PU INT SCIENTIFIC LITERATURE, INC PI ALBERTSON PA 1125 WILLIS AVE, ALBERTSON, NY 11507 USA SN 1234-1010 J9 MED SCI MONITOR JI Med. Sci. Monitor PD OCT PY 2007 VL 13 IS 10 BP CR422 EP CR429 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 222XP UT WOS:000250332000008 PM 17901848 ER PT J AU Cheuvront, SN Kenefick, RW Montain, SJ AF Cheuvront, Samuel N. Kenefick, Robert W. Montain, Scott J. TI Important insight from the 2003 Singapore half-marathon SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Letter ID HYPERTHERMIA; EXERCISE C1 US Army Res Inst Environm Med, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA. NR 8 TC 3 Z9 3 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD OCT PY 2007 VL 39 IS 10 BP 1883 EP 1883 DI 10.1249/mss.0b013e318148bbc5 PG 1 WC Sport Sciences SC Sport Sciences GA 217RD UT WOS:000249964100027 PM 17909418 ER PT J AU Jull, AJT Lal, D Taylor, S Wieler, R Grimberg, A Vacher, L McHargue, LR Freeman, SPHT Maden, C Schnabel, C Xu, S Finkel, RC Kim, KJ Marti, K AF Jull, A. J. T. Lal, D. Taylor, S. Wieler, R. Grimberg, A. Vacher, L. McHargue, L. R. Freeman, S. P. H. T. Maden, C. Schnabel, C. Xu, S. Finkel, R. C. Kim, K. J. Marti, K. TI He-3, Ne-20,Ne-21,Ne-22, C-14, Be-10, (26)AI, and (CI)-C-36 in magnetic fractions of cosmic dust from Greenland and Antarctica SO METEORITICS & PLANETARY SCIENCE LA English DT Article ID SOLAR ENERGETIC PARTICLES; INTERPLANETARY DUST; NOBLE-GASES; EXTRATERRESTRIAL ORIGIN; STRATOSPHERIC PARTICLES; EXPOSURE HISTORY; ACCRETION RATE; EXCESS HE-3; SOUTH-POLE; SPHERULES AB We report on studies of the concentrations of cosmogenic nuclides in the magnetic fraction of cosmic dust particles recovered from the South Pole Water Well (SPWW) and from Greenland. Our results confirm that cosmic dust material from these locations contains measurable amounts of cosmogenic nuclides. The Antarctic particles (and possibly those from Greenland as well) also contain minor amounts of solar Ne. Concentrations of cosmogenic nuclides are consistent with irradiation of this material as small objects in space, with exposure ages similar to the expected Poynting-Robertson (P-R) lifetimes of 50-200 kyr for particles 25-100 mu m in size. C1 [Jull, A. J. T.; McHargue, L. R.] Univ Arizona, NSF Arizona AMS Lab, Tucson, AZ 85721 USA. [Lal, D.; Vacher, L.] Univ Calif San Diego, Scripps Inst Oceanog, Div Geol Res, La Jolla, CA 92093 USA. [Taylor, S.] Cold Reg Res Lab, Hanover, NH 03755 USA. [Wieler, R.; Grimberg, A.] ETH, NW C84, CH-8092 Zurich, Switzerland. [McHargue, L. R.; Freeman, S. P. H. T.; Maden, C.; Schnabel, C.; Xu, S.] Scottish Univ Environm Res Ctr, E Kilbride G75 0QF, Lanark, Scotland. [Finkel, R. C.] Lawrence Livermore Natl Lab, Ctr Accelerator Mass Spectrometry, Livermore, CA 94550 USA. [Marti, K.] Univ Calif San Diego, Dept Chem, La Jolla, CA 92093 USA. [Kim, K. J.] Korea Inst Geosci & Mineral Resources, Taejon 305350, South Korea. RP Jull, AJT (reprint author), Univ Arizona, NSF Arizona AMS Lab, Phys Bldg,1118 E 4th St, Tucson, AZ 85721 USA. EM jull@email.arizona.edu RI Wieler, Rainer/A-1355-2010; Freeman, Stewart/C-3290-2012 OI Wieler, Rainer/0000-0001-5666-7494; Freeman, Stewart/0000-0001-6148-3171 NR 59 TC 2 Z9 2 U1 0 U2 7 PU METEORITICAL SOC PI FAYETTEVILLE PA DEPT CHEMISTRY/BIOCHEMISTRY, UNIV ARKANSAS, FAYETTEVILLE, AR 72701 USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD OCT PY 2007 VL 42 IS 10 BP 1831 EP 1840 PG 10 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 253PI UT WOS:000252529700011 ER PT J AU Scoville, SL Gubata, ME Potter, RN White, MJ Pearse, LA AF Scoville, Stephanie L. Gubata, Marlene E. Potter, Robert N. White, Michelle J. Pearse, Lisa A. TI Deaths attributed to suicide among enlisted US Armed Forces recruits, 1980-2004 SO MILITARY MEDICINE LA English DT Article ID MARINE CORPS; MILITARY; PERSONNEL; NAVY AB Objective: The purpose of this study was to describe the epidemiology of suicides among U.S. Air Force, Army, Marine Corps, and Navy recruits from 1980 through 2004. Methods: Recruit suicides were identified through the Department of Defense Recruit Mortality Registry. We calculated crude, category-specific, and age-adjusted mortality rates as deaths per 100,000 recruit-years. Results: There were 46 onsite suicides by gunshot (39%), hanging (35%), fall/jump (22%), and drug overdose (4%). An additional 20 recruits committed suicide from 1980 through 2004 after leaving the military training site. Methods included gunshot (70%), hanging (20%), fall/jump (5%), and poisoning (5%). Therefore, the overall recruit suicide rate was 6.9 (95% confidence interval = 5.4-8.8) deaths per 100,000 recruit-years. Only three (5%) suicides occurred among females resulting in a 3.5 times higher risk for males compared to females (95% confidence interval = 1.1-11.2). Conclusions: Suicide rates among military recruits were lower than those of comparably aged U.S. civilians. However, the occurrence of any suicide during basic military training emphasizes the importance of routine evaluation of the effectiveness of each military service's suicide prevention program as it applies to this population. C1 USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Silver Spring, MD 20910 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Armed Forces Inst Pathol, Mortal Surveillance Div, Off Armed Forces Med Examiner, Rockville, MD 20850 USA. RP Scoville, SL (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Silver Spring, MD 20910 USA. NR 22 TC 16 Z9 17 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2007 VL 172 IS 10 BP 1024 EP 1031 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 221UE UT WOS:000250252000002 PM 17985760 ER PT J AU Millikan, AM Weber, NS Niebuhr, DW Torrey, EF Cowan, DN Li, YZ Kaminski, B AF Millikan, Amy M. Weber, Natalya S. Niebuhr, David W. Torrey, E. Fuller Cowan, David N. Li, Yuanzhang Kaminski, Brenda TI Evaluation of data obtained from military disability medical administrative databases for service members with schizophrenia or bipolar disorder SO MILITARY MEDICINE LA English DT Article ID II DISORDER; SCHIZOAFFECTIVE DISORDER; PSYCHIATRIC RESEARCH; RELIABILITY; DIAGNOSIS; VALIDITY; INTERVIEWS AB Objective: We are studying associations between selected biomarkers and schizophrenia or bipolar disorder among military personnel. To assess potential diagnostic misclassification and to estimate the date of illness onset, we reviewed medical records for a subset of cases. Methods: Two psychiatrists independently reviewed 182 service medical records retrieved from the Department of Veterans Affairs. Data were evaluated for diagnostic concordance between database diagnoses and reviewers. Interreviewer variability was measured by using proportion of agreement and the K statistic. Data were abstracted to estimate date of onset. Results: High levels of agreement existed between database diagnoses and reviewers (proportion, 94.7%; K = 0.88) and between reviewers (proportion, 92.3%; K = 0.87). The median time between illness onset and initiation of medical discharge was 1.6 and 1.1 years for schizophrenia and bipolar disorder, respectively. Conclusions: High levels of agreement between investigators and database diagnoses indicate that diagnostic misclassification is unlikely. Discharge procedure initiation date provides a suitable surrogate for disease onset. C1 Walter Reed Army Inst Res, Div Prevent Med, Dept Epidemiol, Silver Spring, MD 20910 USA. Stanley Med Res Inst, Chevy Chase, MD 20815 USA. Shenandoah Univ, Div Phys Assistant Studies, Lucknow 226014, Uttar Pradesh, India. RP Millikan, AM (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Niebuhr, David/B-7865-2011; OI Li, Yuanzhang/0000-0001-8872-4430 NR 24 TC 10 Z9 10 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2007 VL 172 IS 10 BP 1032 EP 1038 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 221UE UT WOS:000250252000003 PM 17985761 ER PT J AU Zahn, CM Dunlow, SG Alvero, R Parker, JD Nace, MC Armstrong, AY AF Zahn, Christopher M. Dunlow, Susan G. Alvero, Ruben Parker, Jason D. Nace, M. Catherine Armstrong, Alicia Y. TI Too little time to teach? Medical student education and the resident work-hour restriction SO MILITARY MEDICINE LA English DT Article ID SLEEP-DEPRIVATION; TRAINING-PROGRAM; PERFORMANCE; SATISFACTION; LIMITATIONS; EXPERIENCE; OBSTETRICS; ATTITUDES; FATIGUE; SKILLS AB Objective: The purpose of this study was to examine the impact of the resident duty-hour restriction on medical student education through a survey of faculty, residents, and interns, with interns providing experience as students relative to implementation of work-hour restrictions. Methods: A survey was performed at two (one military and one civilian) obstetrics and gynecology residency programs, Additional surveys were obtained from an Association of Professors of Gynecology and Obstetrics workshop, which included military and nonmilitary attendees. Results: The majority of faculty reported spending 5 to 10 hours per week in medical education before and after implementation of the work-hour restriction. Residents reported less time teaching students after work-hour restrictions were instituted. Nearly all interns, responding about their clinical clerkship experience as students, believed their educational experience would have been improved if residents were more involved in teaching. Conclusion: This pilot study suggests residents are less involved in medical student education following implementation of the duty-hour restrictions. C1 Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. Univ Colorado, Hlth Sci Ctr, Dept Obstet & Gynecol, Aurora, CO 80045 USA. NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20814 USA. RP Zahn, CM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. EM czahn@usuhs.mil FU Intramural NIH HHS NR 24 TC 9 Z9 9 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2007 VL 172 IS 10 BP 1053 EP 1057 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 221UE UT WOS:000250252000009 PM 17985765 ER PT J AU DeFraites, RF Chambers, WC AF DeFraites, Robert F. Chambers, William C. TI Gaining experience with military medical Situational awareness and geographic information systems in a simulated influenza epidemic SO MILITARY MEDICINE LA English DT Article ID A H5N1; TRANSMISSION AB The purpose of medical situational awareness is to provide useful and actionable information for preparing and employing medical assets in support of a wide variety of operational missions around the world, and monitoring and protecting the health of the force in the face of rapidly changing health threats. Since 2005, the Medical Situational Awareness in the Theater Advanced Concept Technology Demonstration has exploited advances in information technology, geographic information systems, and open systems architecture to produce a functioning prototype of a medical situational enhancement capability. In May 2006, this prototype supported the medical staff of a combined/joint task force in a realistic command postexercise featuring a simulated outbreak of influenza during Exercise COBRA GOLD in Thailand. The proliferation and maturation of geographic information systems present many opportunities for the military medical community to improve the health of the populations for which it is responsible. C1 USA, MSAT ACTD, Med Res & Mat Command, MCMR ZB AMS, Ft Detrick, MD 21702 USA. RP DeFraites, RF (reprint author), USA, MSAT ACTD, Med Res & Mat Command, MCMR ZB AMS, 504 Scott St, Ft Detrick, MD 21702 USA. NR 23 TC 3 Z9 4 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2007 VL 172 IS 10 BP 1071 EP 1076 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 221UE UT WOS:000250252000013 PM 17985768 ER PT J AU Johnson, EK Paquette, EL AF Johnson, Eric K. Paquette, Edmond L. TI Use of surgisis for abdominal wall Reconstruction/Closure in battlefield casualties during operation Iraqi freedom SO MILITARY MEDICINE LA English DT Article ID SMALL-INTESTINAL SUBMUCOSA; DEFECTS; REPAIR AB A case series and discussion based on experiences gained during Operation Iraqi Freedom are presented. The Army previously published an article on the use of Gore-Tex mesh in the staged closure of open abdominal wounds. We thought that use of a biomaterial could shorten the overall course of abdominal closure and improve outcomes. This is mainly a "proof of concept" type of study. Although class I data are not presented, a useful concept is discussed. To our knowledge, no other report of the use of biomaterials for battle casualties has been published. Several issues that are faced by the military medical system are presented. The use of Surgisis (lyophilized porcine small intestinal submucosa; Cook Biotech, West Lafayette, Indiana) in the described setting is presented as one possible solution. C1 Eisenhower Army Med Ctr, Dept Colorectal Surg & Surg Endoscopy, Ft Gordon, GA 30905 USA. Womack Army Med Ctr, Dept Urol, Ft Bragg, NC 28310 USA. RP Johnson, EK (reprint author), Eisenhower Army Med Ctr, Dept Colorectal Surg & Surg Endoscopy, Ft Gordon, GA 30905 USA. NR 12 TC 8 Z9 8 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2007 VL 172 IS 10 BP 1119 EP 1124 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 221UE UT WOS:000250252000024 PM 17985779 ER PT J AU Lundy, JB Gallo, DR Eastman, DP Perkins, JH AF Lundy, Jonathan B. Gallo, Dominic R. Eastman, Dennis P. Perkins, Jennifer H. TI The use of rigid sternal fixation for complex poststernotomy wounds and a military-unique fracture at an army medical center SO MILITARY MEDICINE LA English DT Article ID OPEN-HEART-SURGERY; CONSECUTIVE OPERATIVE PROCEDURES; INTERNAL-FIXATION; MANDIBLE FRACTURES; STERNOTOMY WOUNDS; PLATE FIXATION; COMPLICATIONS; MANAGEMENT; CLOSURE; INCISION AB Sternal wound complications after sternotomy carry significant morbidity and mortality rates. Sternal fractures attributable to blunt trauma may cause incapacitating pain or may be plagued by symptoms resulting from chronic nonunion. A sternal fixation system has been developed and used successfully for the management of poststernotomy complications, as well as for symptomatic fractures and fracture nonunion. This article reports the successful use of this technique for three patients at our institution. The use of rigid sternal fixation could potentially be extended to include primary sternotomy closure in patients at high risk for sternal dehiscence and nonunion. This technique may also substitute for sternal rewiring in the initial management of poststernotomy complications. C1 Dwight D Eisenhower Army Med Ctr, Gen Surg Serv, Ft Gordon, GA 30905 USA. Dwight D Eisenhower Army Med Ctr, Cardiothorac Surg Serv, Ft Gordon, GA 30905 USA. RP Lundy, JB (reprint author), Dwight D Eisenhower Army Med Ctr, Gen Surg Serv, Ft Gordon, GA 30905 USA. NR 29 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2007 VL 172 IS 10 BP 1125 EP 1128 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 221UE UT WOS:000250252000025 PM 17985780 ER PT J AU Rynearson, A Giannini, C Rodriguez, F Passe, S Blanchard, T McElwain, T Marler, R Jenkins, R AF Rynearson, Amanda Giannini, Caterina Rodriguez, Fausto Passe, Sandra Blanchard, Terrell McElwain, Terry Marler, Ronald Jenkins, Robert TI A subset of spontaneous canine oligodendroglial tumors share genetic similarities with human oligodendrogliomas SO NEURO-ONCOLOGY LA English DT Meeting Abstract CT 12th Annual Meeting of the Society-for-Neuro-Oncology CY NOV 15-18, 2007 CL Dallas, TX SP Soc Neuro Oncol C1 [Rynearson, Amanda; Giannini, Caterina; Rodriguez, Fausto; Passe, Sandra; Jenkins, Robert] Mayo Clin, Coll Med, Lab Med & Pathol, Rochester, MN USA. [Blanchard, Terrell] AFIP, Walter Reed Army Med Ctr, Washington, DC 20306 USA. [McElwain, Terry] Washington State Univ, Coll Vet Sci, Pullman, WA 99164 USA. [Marler, Ronald] Mayo Clin, Scottsdale, AZ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU DUKE UNIV PRESS PI DURHAM PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA SN 1522-8517 J9 NEURO-ONCOLOGY JI Neuro-Oncology PD OCT PY 2007 VL 9 IS 4 BP 536 EP 536 PG 1 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA 218EP UT WOS:000249999100267 ER PT J AU Gehrich, A Stany, MP Fischer, JR Buller, J Zahn, CM AF Gehrich, Alan Stany, Michael P. Fischer, John R. Buller, Jerome Zahn, Christopher M. TI Establishing a mean postvoid residual volume in asymptomatic perimenopausal and postmenopausal women SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID LOWER URINARY-TRACT; PELVIC ORGAN PROLAPSE; INCONTINENT WOMEN; FEMALE BLADDER; OLD AGE; ULTRASOUND; CYSTOMETROGRAMS; UROFLOWMETRY; POPULATION; PREVALENCE AB OBJECTIVE: To estimate mean postvoid residual (PVR) volumes among perimenopausal and postmenopausal women without significant lower urinary tract or pelvic organ prolapse symptoms. METHODS: Patients presenting for well-women encounters were offered study participation. Women with a history of urinary incontinence greater than twice per week, urinary retention, symptomatic pelvic organ prolapse, or neurologic disorders were excluded. Pelvic relaxation, if present, was characterized according to the pelvic organ prolapse quantification system. Within 10 minutes of spontaneously voiding, PVR volume was assessed with bladder ultrasonography. RESULTS: A total of 96 patients were enrolled; mean age was 60 11 years. The majority (80%) were postmenopausal; 30% had a previous hysterectomy. Most women (92%) had some degree of prolapse; the median stage was one, most commonly involving the anterior compartment (70%). The median PVR volume was 19 mL (range 0-145 mL); the mean PVR volume was 24 29 mL. Only 15% of patients had a PVR volume greater than 50 mL, and 95% had a PVR volume 100 mL or less. Only age 65 years or older was associated with a higher mean PVR volume; hormone therapy, vaginal atrophy, parity, and stage of asymptomatic prolapse did not affect PVR volumes. CONCLUSION: Most asymptomatic perimenopausal and postmenopausal women had a PVR volume less than 50 mL, which was unaffected by multiple factors that were thought to potentially affect bladder function. Establishing "normal" volumes in this population may aid in developing recommendations regarding appropriate bladder function and retention criteria for women who are symptomatic or those who have had pelvic floor surgery. C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. RP Gehrich, A (reprint author), Tripler Army Med Ctr, Chief Urogynecol & RPS Serv, Honolulu, HI 96859 USA. EM alan.gehrich@amedd.army.mil NR 24 TC 18 Z9 19 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD OCT PY 2007 VL 110 IS 4 BP 827 EP 832 DI 10.1097/01.AOG.0000284445.68789.ee PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 217VA UT WOS:000249974200015 PM 17906016 ER PT J AU Levens, ED DeCherney, AH AF Levens, Eric D. DeCherney, Alan H. TI Severe menorrhagia associated with thrombocytopenia SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID BLEEDING DISORDERS; ENDOMETRIAL ABLATION; WOMEN; TRANSPLANTATION; PLATELET C1 NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. Natl Inst Hlth, Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NHLBI, NIH, Hematol Branch, Bethesda, MD 20892 USA. RP Levens, ED (reprint author), NICHHD, Reprod Biol & Med Branch, NIH, Bldg 10,CRC,Room E1-3140,10 Ctr Dr, Bethesda, MD 20892 USA. EM levense@mail.nih.gov OI Scheinberg, Phillip/0000-0002-9047-4538 NR 15 TC 7 Z9 7 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD OCT PY 2007 VL 110 IS 4 BP 913 EP 917 DI 10.1097/01.AOG.0000279138.64895.2b PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 217VA UT WOS:000249974200027 PM 17906028 ER PT J AU Brown, J Hacker, H Schuschereba, ST Zwick, H Lund, DJ Stuck, BE AF Brown, Jeremiah, Jr. Hacker, Henry Schuschereba, Steven T. Zwick, Harry Lund, David J. Stuck, Bruce E. TI Steroidal and nonsteroidal antiinflammatory medications can improve photoreceptor survival after laser retinal photocoagulation SO OPHTHALMOLOGY LA English DT Article ID DIABETIC MACULAR EDEMA; INTRAVITREAL TRIAMCINOLONE ACETONIDE; SPINAL-CORD INJURY; METHYLPREDNISOLONE THERAPY; CONTROLLED TRIAL; RECOVERY; DAMAGE; CORTICOSTEROIDS; ACTIVATION; MECHANISMS AB Objective: To determine whether methylprednisolone or indomethacin can enhance photoreceptor survival after laser retinal injury in an animal model. Design: Experimental study. Participants: Twenty rhesus monkeys. Methods: Twenty rhesus monkeys (Macaca mulatta) received a grid of argon green (514.5 nm, 10 ms) laser lesions in the macula of the right eye and a grid of neodymium:yttrium-aluminum-garnet (Nd:YAG; 1064 nm, 10 ns) lesions in the macula of the left eye, followed by randomization to 2 weeks of treatment in 1 of 4 treatment groups: high-dose methylprednisolone, moderate-dose methylprednisolone, indomethacin, or control. The lesions were assessed at day 1, day 14, 2 months, and 4 months. The authors were masked to the treatment group. This report discusses the histologic results of ocular tissue harvested at 4 months. Main Outcome Measure: The number of surviving photoreceptor cell nuclei within each lesion was compared with the number of photoreceptor nuclei in surrounding unaffected retina. The proportion of surviving photoreceptor nuclei was compared between each treatment group. Results: Argon retinal lesions in the high-dose steroid treatment group and the indomethacin treatment group demonstrated improved photoreceptor survival compared with the control group (P = 0.004). Hemorrhagic Nd:YAG lesions demonstrated improved survivability with indomethacin treatment compared with controls (P = 0.003). In nonhemorrhagic Nd:YAG laser retinal lesions, the lesions treated with moderate-dose steroids demonstrated improved photoreceptor survival compared with the control group (P = 0.004). Conclusions: Based on histologic samples of retinal laser lesions 4 months after injury, treatment with indomethacin resulted in improved photoreceptor survival in argon laser lesions and hemorrhagic Nd:YAG laser lesions. Treatment with systemic methylprednisolone demonstrated improved photoreceptor survival in argon retinal lesions and in nonhemorrhagic Nd:YAG lesions. C1 USA, Med Res Detachment, Walter Reed Army Inst Res, Brooks AFB, TX 78235 USA. Univ Texas, Hlth Sci Ctr, Dept Ophthalmol, San Antonio, TX 78285 USA. Ophthalmol Associates San Antonio, San Antonio, TX USA. Northrup Grumman Informat Technol, San Antonio, TX USA. RP Brown, J (reprint author), USA, Med Res Detachment, Walter Reed Army Inst Res, 7965 Dave Erwin Dr, Brooks AFB, TX 78235 USA. EM jeremiah.brown@brooks.af.mil NR 43 TC 8 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD OCT PY 2007 VL 114 IS 10 BP 1876 EP 1883 DI 10.1016/j.ophtha.2007.04.035 PG 8 WC Ophthalmology SC Ophthalmology GA 214XU UT WOS:000249772500012 PM 17908593 ER PT J AU Kudenov, MW Hagen, NA Dereniak, EL Gerhart, GR AF Kudenov, Michael W. Hagen, Nathan A. Dereniak, Eustace L. Gerhart, Grant R. TI Fourier transform channeled spectropolarimetry in the MWIR SO OPTICS EXPRESS LA English DT Article AB A complete Fourier Transform Spectropolarimeter in the MWIR is demonstrated. The channeled spectral technique, originally developed by K. Oka, is implemented with the use of two Yttrium Vanadate (YVO4) crystal retarders. A basic mathematical model for the system is presented, showing that all the Stokes parameters are directly present in the interferogram. Theoretical results are compared with real data from the system, an improved model is provided to simulate the effects of absorption within the crystal, and a modified calibration technique is introduced to account for this absorption. Lastly, effects due to interferometer instabilities on the reconstructions, including nonuniform sampling and interferogram translations, are investigated and techniques are employed to mitigate them. (c) 2007 Optical Society of America. C1 Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. USA, TACOM, Warren, MI 48397 USA. RP Kudenov, MW (reprint author), Univ Arizona, Coll Opt Sci, 1630 E Univ Blvd, Tucson, AZ 85721 USA. OI Hagen, Nathan/0000-0003-1122-9081 NR 12 TC 40 Z9 40 U1 1 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD OCT 1 PY 2007 VL 15 IS 20 BP 12792 EP 12805 DI 10.1364/OE.15.012792 PG 14 WC Optics SC Optics GA 218HN UT WOS:000250006700026 PM 19550549 ER PT J AU Saul, A Hensmann, M Sattabongkot, J Collins, WE Barnwell, JW Langermans, JAM Wu, Y Long, CA Dubovsky, F Thomas, AW AF Saul, A. Hensmann, M. Sattabongkot, J. Collins, W. E. Barnwell, J. W. Langermans, J. A. M. Wu, Y. Long, C. A. Dubovsky, F. Thomas, A. W. TI Immunogenicity in rhesus of the Plasmodium vivax mosquito stage antigen Pvs25H with Alhydrogel and Montanide ISA 720 SO PARASITE IMMUNOLOGY LA English DT Article DE Alhydrogel; aluminium hydroxide; Montanide ISA 720; Plasmodium vivax; Pvs25H; rhesus ID TRANSMISSION-BLOCKING ACTIVITY; VACCINE CANDIDATES PVS25; PAPUA-NEW-GUINEA; MALARIA VACCINE; ADJUVANT; ISA-720; SAFETY; TRIAL; ICC-1132; EFFICACY AB Pvs25 is an ookinete surface protein from Plasmodium vivax that is the target of transmission-blocking antibodies. Two immunogenicity trials in rhesus monkeys with a recombinant form of the protein, Pvs25H, were undertaken. Monkeys were vaccinated with Pvs25H adsorbed to Alhydrogel or emulsified in Montanide ISA 720 at 0, 4 and 27 weeks (study 1) or in Montanide ISA 720 at 0 and 18 weeks (study 2) with 1.5 or 15 mu g Pvs25H in 0.1 or 0.5 mL of emulsion (four combinations). Immunogenicity was assessed by ELISA and by membrane-feeding experiments using P. vivax-infected blood from human volunteers (studies 1 and 2) or from chimpanzees (study 1). Both vaccine trials generated antibodies that blocked transmission of P. vivax to mosquitoes. Antibody titres and transmission blocking were higher with Montanide ISA 720 than with Alhydrogel in the first trial and with the 15 mu g Pvs25H/0.5 mL ISA 720 combination in the second trial. C1 NIAID, Lab Malaria & Vector Res, Malaria Vaccine Dev Branch, NIH, Rockville, MD 20852 USA. GH Rijswijk, Biomed Primate Res Ctr, Dept Parasitol, Rijswijk, Netherlands. USA Med Component, Dept Entomol, Armed Forces Res Inst Med Sci, Bangkok, Thailand. CDC, Div Parasit Dis, Natl Ctr Infect Dis, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. PATH Malaria Vaccine Initiat, Bethesda, MD USA. RP Saul, A (reprint author), NIAID, Lab Malaria & Vector Res, Malaria Vaccine Dev Branch, NIH, Twinbrook 3,Room 1E-04,12735 Twinbrook Pkwy, Rockville, MD 20852 USA. EM asaul@niaid.nih.gov RI Saul, Allan/I-6968-2013 OI Saul, Allan/0000-0003-0665-4091 FU Intramural NIH HHS NR 21 TC 17 Z9 20 U1 1 U2 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0141-9838 J9 PARASITE IMMUNOL JI Parasite Immunol. PD OCT PY 2007 VL 29 IS 10 BP 525 EP 533 DI 10.1111/j.1365-3024.2007.00971.x PG 9 WC Immunology; Parasitology SC Immunology; Parasitology GA 215RL UT WOS:000249826600004 PM 17883455 ER PT J AU Bauman, RA Widholm, JJ AF Bauman, Richard Alexander Widholm, John J. TI Operant leverpressing and wheelrunning were differentially reduced by PAPP (p-aminopropiophenone)-induced methemoglobinemia SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE cyanide; p-aminopropiophenone; methemoglobin; energy metabolism; operant behaviour ID PARA-AMINOPROPIOPHENONE; CYANIDE; PERFORMANCE; REDUCTION; KINETICS; DEATH; FOOD; CELL AB Cyanide is a potent toxin that binds to cytochrome oxidase blocking electron transfer and the synthesis of adenosine triphosphate (ATP). Many antidotes to cyanide poisoning oxidize hemoglobin to methemoglobin (metHb), which serves as a scavenger of the cyanide anion. However, sufficiently high levels of metHb can be toxic because metHb cannot bind O-2 ntil it is reduced. The purpose of the proposed study was twofold: (1) Characterize the time course of metHb formation for different doses of p-aminopropiophenone (PAPP), a drug that oxidizes hemoglobin and can be used as an antidote to cyanide intoxication; and (2) Determine whether the effort of an operant response affects the behavioral toxicity of metHb, since more effortful responses presumably are more energetically demanding. In Experiment 1, the oral metHb kinetics of p-aminopropiophenone (PAPP) were studied; four doses of PAPP (1, 5, 10, and 20 mg/kg) or the vehicle, polyethylene glycol 200 (PEG200), were delivered via a gavage tube to separate groups of rats. In Experiment 11, rats were trained to press a lever or run in an activity wheel at any time during a 12-hour light/dark cycle for their entire daily food intake; five presses or turns were required for the delivery of each food pellet. The same doses of PAPP were delivered p.o. shortly before the onset of darkness, 2 100 h. Results from Exp I showed that PAPP induced a dose-dependent rapid increase and relatively slower exponential-Re decline in metHb concentration. In Exp. II, the same doses of PAPP induced a dose-dependent reduction in hourly outputs of leverpresses and wheelturns however; wheelturns were reduced significantly more than leverpresses. When the best-fitting metHb curves from Experiment I were superimposed on the time scale for outputs of wbeelturns and leverpresses, reduction of output was inversely related to the kinetics of metHb formation. These findings are consistent with the conclusion that PAPP-induced metHb formation reduced the output of wheelrunning more than leverpressing because the more energetically demanding response of wheelrunning was more affected by metHb induced hypoxemia. Furthermore, these data suggest that although certain longacting metHb formers might be useful prophylactics for warfighters, it will be critical to determine the energetic loads of required battlefield activities because even low (10%) therapeutic metHb levels might impair the performance of those activities. (c) 2007 Published by Elsevier Inc. C1 Walter Reed Army Inst Res, Div Mil Casualty Res, Dept Polytrauma & Resuscitat, Silver Spring, MD 20910 USA. Coll Charleston, Dept Psychol, Charleston, SC 29424 USA. RP Bauman, RA (reprint author), Walter Reed Army Inst Res, Div Mil Casualty Res, Dept Polytrauma & Resuscitat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM richard.a.bauman@us.army.mil NR 18 TC 1 Z9 1 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD OCT PY 2007 VL 87 IS 4 BP 444 EP 452 DI 10.1016/j.pbb.2007.05.021 PG 9 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA 208QD UT WOS:000249333400008 PM 17658589 ER PT J AU Consolo, G Azzerboni, B Gerhart, G Melkov, GA Tiberkevich, V Slavin, AN AF Consolo, Giancarlo Azzerboni, Bruno Gerhart, Grant Melkov, Gennady A. Tiberkevich, Vasil Slavin, Andrei N. TI Excitation of self-localized spin-wave bullets by spin-polarized current in in-plane magnetized magnetic nanocontacts: A micromagnetic study SO PHYSICAL REVIEW B LA English DT Article ID REMAGNETIZATION PROCESSES; ELECTRIC-CURRENT; DRIVEN; SIMULATIONS; MULTILAYER; GENERATION; DYNAMICS; SYSTEMS; FILMS AB It was shown by micromagnetic simulation that a current-driven in-plane magnetized magnetic nanocontact, besides a quasilinear propagating ("Slonczewski") spin-wave mode, can also support a nonlinear self-localized spin-wave "bullet" mode that exists in a much wider range of bias currents. The frequency of the bullet mode lies below the spectrum of linear propagating spin waves, which makes this mode evanescent and determines its spatial localization. The threshold current for the excitation of the self-localized bullet is substantially lower than for the linear propagating mode, but finite-amplitude initial perturbations of magnetization are necessary to generate a bullet in our numerical simulations, where thermal fluctuations are neglected. Consequently, in these simulations the hysteretic switching between the propagating and localized spin-wave modes is found when the bias current is varied. C1 [Consolo, Giancarlo; Azzerboni, Bruno] Univ Messina, Dipartimento Fis Mat Tecnol Fis Avanzate, I-98166 Messina, Italy. [Gerhart, Grant] US Army TARDEC, Warren, MI 48397 USA. [Melkov, Gennady A.] Univ Kiev, Natl Taras Shevchenko, Fac Radiophys, UA-01033 Kiev, Ukraine. [Tiberkevich, Vasil; Slavin, Andrei N.] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. RP Consolo, G (reprint author), Univ Messina, Dipartimento Fis Mat Tecnol Fis Avanzate, Salita Sperone 31, Vill S Agata, I-98166 Messina, Italy. RI Tiberkevich, Vasil/A-8697-2008; OI Tiberkevich, Vasil/0000-0002-8374-2565; AZZERBONI, Bruno/0000-0001-7642-6540; consolo, giancarlo/0000-0002-6368-8733 NR 26 TC 44 Z9 44 U1 3 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD OCT PY 2007 VL 76 IS 14 AR 144410 DI 10.1103/PhysRevB.76.144410 PG 8 WC Physics, Condensed Matter SC Physics GA 226WX UT WOS:000250620300060 ER PT J AU Krakauer, T Stephens, J Buckley, M Tate, M AF Krakauer, Teresa Stephens, Julie Buckley, Marilyn Tate, Mallory TI Superantigen-induced cytokine release from whole-blood cell culture as a functional measure of drug efficacy after oral dosing in nonhuman primates SO RESEARCH IN VETERINARY SCIENCE LA English DT Article DE pentoxifylline; cytokines; whole-blood cell culture ID TOXIC-SHOCK-SYNDROME; TUMOR-NECROSIS-FACTOR; STAPHYLOCOCCAL ENTEROTOXIN-B; BACTERIAL SUPERANTIGENS; LETHAL SHOCK; FACTOR-ALPHA; INHIBITION; ACTIVATION; IL-1-BETA; DISEASE AB Evaluation of drug efficacy for human diseases is routinely performed in animal models for efficiency and in accordance with FDA regulations. Rhesus macaques have been used as models for various lethal diseases and correlates of immunity, as nonhuman primates (NHP) closely resemble humans. We examined the ex vivo cytokine response of superantigen-stimulated whole-blood cells as a first step to therapeutic efficacy testing for bacterial superantigen-induced shock in NHP after oral dosing of pentoxifylline. Doses of 120 mg/kg of pentoxifylline effectively attenuated staphylococcal enterotoxin B-induced tumor necrosis factor alpha (TNF alpha), gamma interferon (IFN gamma) and interleukin 2 (IL-2) in ex vivo culture of NHP whole-blood cells by 88%, 81%, and 76%, respectively, whereas lower doses of 48 or 72 mg/kg had no inhibitory effect. Thus cytokine release of stimulated peripheral blood cells provides a convenient biological measurement of the anti-inflammatory potency of pentoxifylline and has the advantage of assessing functional responses to a specific biotoxin of interest. Published by Elsevier Ltd. C1 USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Vet Med Div, Frederick, MD 21702 USA. Ctr Dis Control & Prevent, Anim Resources Branch, Sci Resources Program, Atlanta, GA 30333 USA. RP Krakauer, T (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. EM teresa.krakauer@amedd.army.mil NR 30 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0034-5288 J9 RES VET SCI JI Res. Vet. Sci. PD OCT PY 2007 VL 83 IS 2 BP 182 EP 187 DI 10.1016/j.rvsc.2006.12.004 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA 195LR UT WOS:000248414200007 PM 17412377 ER PT J AU Sondeen, JL Dubick, MA Holcomb, JB Wade, CE AF Sondeen, Jill L. Dubick, Michael A. Holcomb, John B. Wade, Charles E. TI Uncontrolled hemorrhage differs from volume- or pressure-matched controlled hemorrhage in swine SO SHOCK LA English DT Article DE aortotomy; controlled hemorrhage; hemodynamics; lactate; pigs ID AFFERENT NERVE-STIMULATION; V LIVER-INJURIES; HYPERTONIC SALINE; SHOCK; MODEL; RATS; RESUSCITATION; RECEPTORS; RESPONSES; THROMBIN AB Controversy continues as to whether uncontrolled or controlled hemorrhage is the most appropriate for the study of hemorrhagic shock and resuscitation. To appraise differences between these models, we evaluated the relationship between blood volume loss and blood pressure in controlled versus uncontrolled hemorrhage. Anesthetized, instrumented, immature female pigs (40 kg) were assigned to one of three groups: (1) group U, uncontrolled aortotomy hemorrhage from a 2-mm aortotomy; (2) group P, controlled hemorrhage matched to the blood pressure profile of group U; or (3) group V, controlled hemorrhage matched to the blood volume loss profile of group U. A computer-driven feedback control system duplicated the group U profiles. Pigs were monitored for 3 h after hemorrhage and received no fluid resuscitation. Group U resulted in a blood loss of 17.6 +/- 0.7 mL kg(-1) and a reduction in blood pressure to 28 +/- 3 mmHg at the end of active bleeding. Group P pigs required more blood loss (21.5 +/- 1.2 mL kg(-1)) to match profiles of group U blood pressure, whereas group V pigs resulted in a higher mean arterial pressure (42 +/- 5 mmHg) to match group U blood volume loss profiles. Neither heart rate nor total peripheral resistance differed significantly among the three groups. At the level of blood loss observed in this study, fundamental physiological differences existed between uncontrolled hemorrhage and controlled hemorrhage when matched for pressure or volume. We suggest that the relationship of blood pressure to blood volume loss is modified in the presence of uncontrolled hemorrhage. C1 USA, Inst Surg Res, San Antonio, TX USA. RP Sondeen, JL (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM jill.sondeen@amedd.army.mil NR 27 TC 23 Z9 23 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD OCT PY 2007 VL 28 IS 4 BP 426 EP 433 DI 10.1097/shk.0b013e31804a5791 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 214XL UT WOS:000249771500009 PM 17558347 ER PT J AU Krueger, B Bender, LC Gould, WR Morrow, PC AF Krueger, Bryce Bender, Louis C. Gould, William R. Morrow, Patrick C. TI A fixed-wing sightability model for oryx in desert habitats SO SOUTH AFRICAN JOURNAL OF WILDLIFE RESEARCH LA English DT Article DE census; correction factors; fixed-wing surveys ID ELK; EFFICIENCY; TRANSECT; BIAS AB We investigated factors affecting sightability of oryx (Oryx gazella gazella) during fixed-wing aerial surveys in desert grass-shrubland habitat types to develop a sightability-adjusted population estimator to aid in precise population management. Sightability of oryx was affected by group size, activity, and vegetation type. We used logistic regression to model all possible combinations of the three significant variables, and compared models with a variety of fit and information-theoretic statistics as well as by relative performance. Because no model was superior to the others, we used relative performance among all models and parsimony to select the preferred model. Our preferred model included variables for social group size and three levels of group activity (bedded, standing, moving). This model estimated oryx population size as 3917 (3534-4297) and 3312 (2999-3593) for two annual surveys, and showed a deviance of -0.007 and -0.03 from the grand mean of all models for these surveys, respectively. Full confidence interval widths from complete surveys (100% of area covered) were 19.0% and 17.9% of mean population estimates, allowing for precise estimation and consequently management of the oryx population, although confidence interval widths will vary with group size and behaviour. Oryx surveys should be conducted during periods when group sizes are largest locally, which was the summer in New Mexico, to maximize sightability of oryx and thus minimize variation in population estimates due to sighting error. C1 [Bender, Louis C.] New Mexico Cooperat Fish & Wildlife Res Unit, Las Cruces, NM 88003 USA. [Krueger, Bryce] New Mexico State Univ, Dept Fisheries & Wildlife, Las Cruces, NM 88003 USA. [Gould, William R.] New Mexico State Univ, Dept Econ, Univ Stat Ctr, Las Cruces, NM 88003 USA. [Morrow, Patrick C.] USA, Environm Stewardship Div, White Sands Missile Range, NM 88002 USA. RP Bender, LC (reprint author), New Mexico Cooperat Fish & Wildlife Res Unit, POB 30003 MSC 4901, Las Cruces, NM 88003 USA. EM lbender@nmsu.edu NR 25 TC 2 Z9 2 U1 1 U2 2 PU SOUTHERN AFRICAN WILDLIFE MANAGEMENT ASSOC PI BLOUBERGSTRAND PA P O BOX 217, BLOUBERGSTRAND 7437, SOUTH AFRICA SN 0379-4369 J9 S AFR J WILDL RES JI South Afr. J. Wildl. Res. PD OCT PY 2007 VL 37 IS 2 BP 133 EP 142 DI 10.3957/0379-4369-37.2.133 PG 10 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 249SN UT WOS:000252250100004 ER PT J AU Devine, PJ Sullenberger, LE Bellin, DA Atwood, JE AF Devine, Patrick J. Sullenberger, Lance E. Bellin, Daniel A. Atwood, J. Edwin TI Jugular venous pulse: Window into the right heart SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE jugular venous pulse; right atrial pressure; neck veins ID CONSTRICTIVE PERICARDITIS; HEPATOJUGULAR REFLUX; PRESSURE; FAILURE; HEMODYNAMICS; INFARCTION; DIAGNOSIS; PATIENT; SOUND; VEINS AB Although physicians began associating conspicuous neck veins with heart disease almost three centuries ago, the jugular venous pulse remains an often ignored component of the physical examination. Many physicians have not invested in the necessary understanding of the technique, and there is a misconception that its examination is difficult and of limited clinical value. When performed properly, evaluation of the jugular venous pulse can be extremely useful in distinguishing the cause of dyspnea and edema. The normal jugular venous pulse is reviewed, and pulse wave abnormalities are described, including ways in which they can provide clues to the diagnosis of certain disease states, ranging from pericardial disease to conduction disturbances. The jugular venous pulse provides a window into the right heart and an occasional glimpse of left heart hemodynamics. By peering through this window, clinicians can gain valuable information in the diagnostic evaluation of the cardiovascular patient. C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Devine, PJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave,NW,Bldg 2,Room 3L28, Washington, DC 20307 USA. EM patrick.devine@na.amedd.army.mil NR 36 TC 6 Z9 6 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD OCT PY 2007 VL 100 IS 10 BP 1022 EP 1027 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 222BS UT WOS:000250271700016 PM 17943049 ER PT J AU Vaccaro, AR Hulbert, J Patel, AA Fisher, C Dvorak, M Lehman, RA Anderson, P Harrop, J Oner, FC Arnold, P Fehlings, M Hedlund, R Madrazo, I Rechtine, G Aarabi, B Shainline, M AF Vaccaro, Alexander R. Hulbert, John Patel, Alpesh A. Fisher, Charles Dvorak, Marcel Lehman, Ronald A. Anderson, Paul Harrop, James Oner, F. C. Arnold, Paul Fehlings, Michael Hedlund, Rune Madrazo, Ignacio Rechtine, Glenn Aarabi, Bizhan Shainline, Mike CA Spine Trauma Study Grp TI The subaxial cervical spine injury classification system SO SPINE LA English DT Article DE Sub-axial Injury Classification (SLIC) and; Severity Scale; subaxial cervical spine injury; classification system ID FRACTURES; TRAUMA; DISLOCATIONS; MANAGEMENT AB Study Design. The classification system was derived through a literature review and expert opinion of experienced spine surgeons. In addition, a multicenter reliability and validity study of the system was conducted on a collection of trauma cases. Objectives. To define a novel classification system for subaxial cervical spine trauma that conveys information about injury pattern, severity, treatment considerations, and prognosis. To evaluate reliability and validity of this system. Summary of Background Data. Classification of subaxial cervical spine injuries remains largely descriptive, lacking standardization and prognostic information. Methods. Clinical and radiographic variables encountered in subaxial cervical trauma were identified by a working section of the Spine Trauma Study Group. Significant limitations of existing systems were defined and addressed within the new system. This system, as well as the Harris and Ferguson & Allen systems, was applied by 20 spine surgeons to 11 cervical trauma cases. Six weeks later, the cases were randomly reordered and again scored. Interrater reliability, intrarater reliability, and validity were assessed. Results. Each of 3 main categories ( injury morphology, disco-ligamentous complex, and neurologic status) identified as integrally important to injury classification was assigned a weighted score; the injury severity score was obtained by summing the scores from each category. Treatment options were assigned based on threshold values of the severity score. Interrater agreement as assessed by intraclass correlation coefficient of the DLC, morphology, and neurologic status scores was 0.49, 0.57, and 0.87, respectively. Intrarater agreement as assessed by intraclass correlation coefficient of the DLC, morphology, and neurologic status scores was 0.66, 0.75, and 0.90, respectively. Raters agreed with treatment recommendations of the algorithm in 93.3% of cases, suggesting high construct validity. The reliability compared favorably to the Harris and Ferguson & Allen systems. Conclusion. The Sub-axial Injury Classification and Severity Scale provides a comprehensive classification system for subaxial cervical trauma. Early validity and reliability data are encouraging. C1 Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19107 USA. Univ Calgary, Spine Program, Calgary, AB T2N 1N4, Canada. Univ Utah, Sch Med, Dept Orthopaed Surg, Salt Lake City, UT 84112 USA. Vancouver Gen Hosp, Vancouver, BC, Canada. Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Univ Wisconsin, Madison, WI 53706 USA. Univ Utrecht Hosp, Utrecht, Netherlands. Univ Kansas Hosp, Kansas City, KS USA. Toronto Western Hosp, Toronto, ON M5T 2S8, Canada. Huddinge Univ Hosp, Stockholm, Sweden. Hosp Angeles Pedregal, Dept Neurosci, Mexico City, DF, Mexico. Univ Rochester, Rochester, NY 14627 USA. Univ Maryland, Baltimore, MD 21201 USA. PhDx Syst, Albuquerque, NM USA. RP Vaccaro, AR (reprint author), Rothman Inst, 925 Chestnut St,5th Floor, Philadelphia, PA 19107 USA. EM alexvaccaro3@aol.com RI Oner, FC/L-7769-2013 OI Oner, FC/0000-0003-0858-8243 NR 20 TC 111 Z9 139 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD OCT 1 PY 2007 VL 32 IS 21 BP 2365 EP 2374 PG 10 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 217AY UT WOS:000249922000013 PM 17906580 ER PT J AU Fox, CJ Starnes, BW AF Fox, Charles J. Starnes, Benjamin W. TI Vascular surgery on the modern battlefield SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID REQUIRING MASSIVE TRANSFUSION; DAMAGE CONTROL RESUSCITATION; OPERATION ENDURING FREEDOM; RECOMBINANT FACTOR VIIA; ACTIVATED FACTOR-VII; TRAUMA PATIENTS; ACQUIRED COAGULOPATHY; HEMORRHAGE CONTROL; ARTERY INJURIES; LOWER-EXTREMITY AB Management of traumatic vascular injury can offer special challenges even to experienced surgeons who are functioning in resource-limited situations. Lessons learned from past conflicts have advanced the practice of vascular trauma surgery on the battlefield and in urban trauma centers. Current conflicts provide a fresh opportunity to examine those recent advancements that have improved surgical capability and as a result have changed the practice of vascular surgery on the modern battlefield. This article provides an overview of the contemporary management of vascular injuries in combat casualties during recent United States military operations. C1 [Fox, Charles J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Fox, Charles J.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Starnes, Benjamin W.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Fox, CJ (reprint author), Walter Reed Army Med Ctr, Bldg 2,Ward 64,6900 Georgia Ave NW, Washington, DC 20307 USA. EM charles.fox@us.army.mil NR 84 TC 20 Z9 21 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD OCT PY 2007 VL 87 IS 5 BP 1193 EP + DI 10.1016/j.suc.2007.07.015 PG 20 WC Surgery SC Surgery GA 249ES UT WOS:000252210700014 PM 17936482 ER PT J AU Pak, HS AF Pak, Hon S. TI Telethinking SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Editorial Material C1 US Army Med Res & Materiel Command, American Telemed Assoc, Adv Informat Technol Grp, Ft Detrick, MD 21702 USA. RP Pak, HS (reprint author), US Army Med Res & Materiel Command, American Telemed Assoc, Adv Informat Technol Grp, Ft Detrick, MD 21702 USA. EM Pak@TATRC.org NR 0 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD OCT PY 2007 VL 13 IS 5 BP 483 EP 486 DI 10.1089/tmj.2007.9976 PG 4 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 233JA UT WOS:000251086000017 PM 17999610 ER PT J AU Myint, KSA Gibbons, RV Perng, GC Solomon, T AF Myint, Khin Saw Aye Gibbons, Robert V. Perng, Guey Chuen Solomon, Tom TI Unravelling the neuropathogenesis of Japanese encephalitis SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Review DE Japanese encephalitis; viral encephalitis; flavivirus; blood-brain barrier; apoptosis; autopsy AB Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia. Mortality rates can be as high as 30%, with one-third of survivors suffering severe neurological sequelae. Viral cytopathology is important, but the contribution of blood-brain barrier breakdown, the inflammatory response and bystander cell death are unknown. Studies that address the mechanisms producing neuronal dysfunction and damage are required, including the examination of autopsy tissues. A better understanding of these mechanisms may lead to therapeutic strategies to reduce brain injury and neurological sequelae. (C) 2007 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved. C1 Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. Univ Liverpool, Div Neurol Sci, Liverpool L69 3GA, Merseyside, England. Univ Liverpool, Div Med Microbiol, Liverpool L69 3GA, Merseyside, England. RP Myint, KSA (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM myintk@afrims.org OI Perng, Oscar/0000-0001-7510-4486 FU Medical Research Council [G116/194]; Wellcome Trust NR 5 TC 12 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD OCT PY 2007 VL 101 IS 10 BP 955 EP 956 DI 10.1016/j.trstmh.2007.04.004 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 218PQ UT WOS:000250027800002 PM 17544469 ER PT J AU Cardo, LJ Salata, J Mendez, J Reddy, H Goodrich, R AF Cardo, Lisa J. Salata, Jeanne Mendez, Juan Reddy, Heather Goodrich, Raymond TI Pathogen inactivation of Trypanosoma cruzi in plasma and platelet concentrates using riboflavin and ultraviolet light SO TRANSFUSION AND APHERESIS SCIENCE LA English DT Article ID CHAGAS-DISEASE; REDUCTION TECHNOLOGY; UNITED-STATES; AMERICAN TRYPANOSOMIASIS; BLOOD; LEISHMANIA; PRODUCTS; EFFICACY AB Background: Emigration of people infected with Trypanosoma cruzi to non-endemic areas has resulted in transfusion transmission to inummocompromised recipients. We studied the feasibility of inactivating T cruzi using a new technology which utilizes riboflavin as a photosensitizer in combination with UV light, Mirasol PRT. Methods: One billion T cruzi organisms and 30 mL of 500 mu M riboflavin were added to each of six units of human plasma and six units of platelets. To determine the level of detection of organism, a sample of each unit was cultured in tenfold serial dilutions beginning with 100 billion/250 mL as the starting culture. After 30 min, each unit was illuminated with 5.9 J/cm(2) of UV light (6.24 J/mL). The units were then cultured again in tenfold serial dilutions post-treatment. Results: A 6 log reduction of pathogens was demonstrated in 5 of 6 units of plasma, and a 7 log reduction of pathogens was demonstrated in one unit. A 6 log reduction of pathogens was demonstrated in 3 of 6 units of platelets, a 7 log reduction was demonstrated in 2 of 6 units of platelets, and an 8 log reduction of pathogens was demonstrated in 1 of 6 units. Conclusions: Mirasol PRT treatment demonstrated an ability to inactivate 5-7 logs of T cruzi in plasma and platelets. (C) 2007 Published by Elsevier Ltd. C1 [Cardo, Lisa J.; Salata, Jeanne; Mendez, Juan] Walter Reed Army Inst Res, Dept Blood Res, Transfus Med Branch, Silver Spring, MD 20910 USA. [Reddy, Heather; Goodrich, Raymond] Navigant Biotechnol, Lakewood, CO USA. RP Cardo, LJ (reprint author), Walter Reed Army Inst Res, Dept Blood Res, Transfus Med Branch, Silver Spring, MD 20910 USA. EM Lisa.Cardo@us.army.mil NR 30 TC 50 Z9 50 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1473-0502 J9 TRANSFUS APHER SCI JI Transfus. Apher. Sci. PD OCT PY 2007 VL 37 IS 2 BP 131 EP 137 DI 10.1016/j.transci.2007.07.002 PG 7 WC Hematology SC Hematology GA 247KR UT WOS:000252078300006 PM 17950672 ER PT J AU Zaretsky, EV Lewicki, DG Savage, M Vlcek, BL AF Zaretsky, Erwin V. Lewicki, David G. Savage, Michael Vlcek, Brian L. TI Determination of turboprop reduction gearbox system fatigue life and reliability SO TRIBOLOGY TRANSACTIONS LA English DT Article DE gearbox life prediction; gearing; rolling-element bearings; Monte Carlo analysis; probabilistic life analysis; weibull; analysis AB Two computational models to determine the fatigue life and reliability of a commercial turboprop gearbox are compared with each other and with field data. These models are (1) Monte Carlo simulation of randomly selected lives of individual bearings and gears comprising the system and (2) two-parameter Weibull distribution function for bearings and gears comprising the system using strict-series system reliability to combine the calculated individual component lives in the gearbox. The Monte Carlo simulation included the virtual testing of 744,450 gearboxes. Two sets of field data were obtained from 64 gearboxes that were first-run to removal for cause, were refurbished and placed back in service, and then were second-run until removal for cause. A series of equations were empirically developed from the Monte Carlo simulation to determine the statistical variation in predicted life and Weibull slope as a function of the number of gearboxes failed. The resultant L-10 life from the field data was 5,627 h. From strict-series system reliability, the predicted L-10 life was 774 h. From the Monte Carlo simulation, the median value for the L-10 gearbox lives equaled 757 h. Half of the gearbox L-10 lives will be less than this value and the other half more. The resultant L-10 life of the second-run (refurbished) gearboxes was 1,334h. The apparent load-life exponent p for the roller bearings is 5.2. Were the bearing lives to be recalculated with a load-life exponent p equal to 5.2, the predicted L-10 life of the gearbox would be equal to the actual life obtained in the field. The component failure distribution of the gearbox from the Monte Carlo simulation was nearly identical to that using the strict-series system reliability analysis, proving the compatibility of these methods. C1 NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. USA, Res Lab, Glenn Res Ctr, Cleveland, OH 44135 USA. Univ Akron, Akron, OH 44325 USA. Georgia So Univ, Statesboro, GA 30460 USA. RP Zaretsky, EV (reprint author), NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. NR 29 TC 4 Z9 4 U1 1 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1040-2004 EI 1547-397X J9 TRIBOL T JI Tribol. Trans. PD OCT-DEC PY 2007 VL 50 IS 4 BP 507 EP 516 DI 10.1080/10402000701613799 PG 10 WC Engineering, Mechanical SC Engineering GA 227VA UT WOS:000250684700008 ER PT J AU Canby-Hagino, E Hernandez, J Brand, TC Troyer, DA Higgons, B Ankerst, DP Thompson, IM Leach, RJ Parekh, DJ AF Canby-Hagino, Edith Hernandez, Javier Brand, Timothy C. Troyer, Dean A. Higgons, Betsy Ankerst, Donna Pauler Thompson, Ian M. Leach, Robin J. Parekh, Dipen J. TI Prostate cancer risk with positive family history, normal prostate examination findings, and PSA less than 4.0 ng/mL SO UROLOGY LA English DT Article ID RADICAL PROSTATECTOMY; MEN; ANTIGEN; METAANALYSIS; POLYMORPHISM; CARCINOMA; RELATIVES; SURVIVAL; FINLAND; DISEASE AB OBJECTIVES Family history has been identified as a risk factor for prostate cancer. We assessed the risk of prostate cancer in men with a positive family history (at least one first-degree or second-degree relative), normal digital rectal examination (DRE) and a serum prostate-specific antigen (PSA) level of 4.0 ng/mL. METHODS A total of 87 volunteers from the San Antonio Center of biomarkers of risk for prostate cancer study enrolled in a prospective study to assess the prevalence of prostate cancer in men with a family history of prostate cancer, normal DRE findings, and a serum PSA level of 4.0 ng/mL or less. All subjects underwent transrectal ultrasound-guided prostate biopsy. RESULTS Prostate cancer was diagnosed in 22 (25.3%) of the 87 participants. The PSA values were significantly greater statistically in the men with prostate cancer (median 2.1 ng/mL) than in the men without prostate cancer (median 1.2 ng/mL, P = 0.01), and the odds of prostate cancer nearly doubled for a doubling of the PSA level within this interval (odds ratio 1.97, P = 0.02). No statistically significant difference was found in age, race, or number and type of affected relatives in men with and without prostate cancer. CONCLUSIONS The results of our study have demonstrated a high frequency of prostate cancer in men with a positive family history but normal DRE findings and a PSA level of 4.0 ng/mL or less. These prospectively collected data raise an important consideration regarding lowering the PSA cutoff values for offering biopsy in patients with a positive family history and normal DRE findings. C1 Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA. Univ Texas Hlth Sci Ctr San Antonio, Dept Cell & Struct Biol, San Antonio, TX 78229 USA. Brooke Army Med Ctr, Div Urol, San Antonio, TX USA. RP Parekh, DJ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, C 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM parekhd@uthscsa.edu FU NCI NIH HHS [U01CA086402] NR 31 TC 9 Z9 10 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD OCT PY 2007 VL 70 IS 4 BP 748 EP 752 DI 10.1016/j.urology.2007.06.1105 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 234FF UT WOS:000251145400027 PM 17991549 ER PT J AU Mazumder, R Hu, ZZ Vinayaka, CR Sagripanti, JL Frost, SDW Pond, SLK Wu, CH AF Mazumder, Raja Hu, Zhang-Zhi Vinayaka, C. R. Sagripanti, Jose-Luis Frost, Simon D. W. Pond, Sergei L. Kosakovsky Wu, Cathy H. TI Computational analysis and identification of amino acid sites in dengue E proteins relevant to development of diagnostics and vaccines SO VIRUS GENES LA English DT Article DE dengue; flavivirus; hemorrhagic virus; selection pressure; T-cell epitope; envelope protein ID T-CELL EPITOPES; ENVELOPE PROTEIN; POSITIVE SELECTION; MOLECULAR EVOLUTION; SEQUENCE ALIGNMENT; MEMBRANE-FUSION; VIRUS; GLYCOPROTEIN; BINDING; FLAVIVIRUS AB We have identified 72 completely conserved amino acid residues in the E protein of major groups of the Flavivirus genus by computational analyses. In the dengue species we have identified 12 highly conserved sequence regions, 186 negatively selected sites, and many dengue serotype-specific negatively selected sites. The flavivirus-conserved sites included residues involved in forming six disulfide bonds crucial for the structural integrity of the protein, the fusion motif involved in viral infectivity, and the interface residues of the oligomers. The structural analysis of the E protein showed 19 surface-exposed nonconserved residues, 128 dimer or trimer interface residues, and regions, which undergo major conformational change during trimerization. Eleven consensus T-h-cell epitopes common to all four dengue serotypes were predicted. Most of these corresponded to dengue-conserved regions or negatively selected sites. Of special interest are six singular sites (N-37, Q(211), D-215, P-217, H-244, K-246) in dengue E protein that are conserved, are part of the predicted consensus T-h-cell epitopes and are exposed in the dimer or trimer. We propose these sites and corresponding epitopic regions as potential candidates for prioritization by experimental biologists for development of diagnostics and vaccines that may be difficult to circumvent by natural or man-made alteration of dengue virus. C1 USA, Edgewood Chem Biol Ctr, AMSRD, ECB,RT, Aberdeen Proving Ground, MD 21010 USA. Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, Washington, DC 20007 USA. Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA. RP Sagripanti, JL (reprint author), USA, Edgewood Chem Biol Ctr, AMSRD, ECB,RT, Aberdeen Proving Ground, MD 21010 USA. EM joseluis.sagripanti@us.army.mil RI Crozier, Laura/A-4821-2010; Frost, Simon/F-3648-2010; Pond, Sergei/G-9830-2012 OI Frost, Simon/0000-0002-5207-9879; Pond, Sergei/0000-0003-4817-4029 FU NIAID NIH HHS [AI43638, AI47745, AI57167]; NIGMS NIH HHS [R01-GM66276]; PHS HHS [A136214] NR 58 TC 20 Z9 20 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-8569 J9 VIRUS GENES JI Virus Genes PD OCT PY 2007 VL 35 IS 2 BP 175 EP 186 DI 10.1007/s11262-007-0103-2 PG 12 WC Genetics & Heredity; Virology SC Genetics & Heredity; Virology GA 192AY UT WOS:000248174300007 PM 17508277 ER PT J AU Ishikawa, Y McQuaid, MJ AF Ishikawa, Yasuyuki McQuaid, Michael J. TI Reactions of NO2 with CH3NHNH and CH3NNH2: A direct molecular dynamics study SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE monomethylhydrazine; CH3NNH2; CH3NHNH; NO2; hypergolic propulsion ID ORBITAL METHODS; RADICAL CATIONS; BASIS SETS; HYDROXYMETHYLENE; FORMALDEHYDE AB Reactive collisions between CH3NNH2 + NO2 and CH3NHNH + NO2 were observed via direct molecular dynamics simulations. The simulations, which are classical trajectories whose dynamics were dictated by forces derived from quantum mechanics-based calculations, were conducted: (1) to confirm the importance of reaction paths expected to play a role in the ignition and combustion of mono-methylhydrazine/nitrogen tetroxide (MMH/NTO) and monomethylhydrazine/red fuming nitric acid (MMH/RFNA) systems, and (2) for their potential to identify unexpected mechanisms. A number of different H-atom abstraction paths were observed, with four isomeric (CH4N2) products being formed: CH3N=NH, CH3NHN, H2C=NNH2, and CH2NHNH. All abstractions were barrierless, including those from the methyl group. Reaction exothermicities, which were characterized via QCISD/6-311 +G(d,P)//MPWB 1K/6-31 +G(d,p) calculations, ranged from 2 to 36 kcal/mol. The results suggest that finite rate chemical kinetics mechanisms for MMH/NTO and MMH/RFNA systems should include steps for the production and decomposition of CH3NHNH, H2C=NNH2, CH2NRNH, and CH3NHN in addition to those for CH3NNH2 and CH3N=NH. (c) 2007 Elsevier B.V. All rights reserved. C1 US Army Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. Univ Puerto Rico, Dept Chem, San Juan, PR 00931 USA. RP McQuaid, MJ (reprint author), US Army Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. EM mcquaid@arl.army.mil NR 21 TC 11 Z9 11 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD SEP 30 PY 2007 VL 818 IS 1-3 BP 119 EP 124 DI 10.1016/j.theochem.2007.05.014 PG 6 WC Chemistry, Physical SC Chemistry GA 213ZV UT WOS:000249706700015 ER PT J AU Lodes, MJ Suciu, D Wilmoth, JL Ross, M Munro, S Dix, K Bernards, K Stover, AG Quintana, M Iihoshi, N Lyon, WJ Danley, DL McShea, A AF Lodes, Michael J. Suciu, Dominic Wilmoth, Jodi L. Ross, Marty Munro, Sandra Dix, Kim Bernards, Karen Stoever, Axel G. Quintana, Miguel Iihoshi, Naomi Lyon, Wanda J. Danley, David L. McShea, Andrew TI Identification of Upper Respiratory Tract Pathogens Using Electrochemical Detection on an Oligonucleotide Microarray SO PLOS ONE LA English DT Article AB Bacterial and viral upper respiratory infections (URI) produce highly variable clinical symptoms that cannot be used to identify the etiologic agent. Proper treatment, however, depends on correct identification of the pathogen involved as antibiotics provide little or no benefit with viral infections. Here we describe a rapid and sensitive genotyping assay and microarray for URI identification using standard amplification and hybridization techniques, with electrochemical detection (ECD) on a semiconductor-based oligonucleotide microarray. The assay was developed to detect four bacterial pathogens (Bordetella pertussis, Streptococcus pyogenes, Chlamydia pneumoniae and Mycoplasma pneumoniae) and 9 viral pathogens (adenovirus 4, coronavirus OC43, 229E and HK, influenza A and B, parainfluinza types 1, 2, and 3 and respiratory syncytial virus. This new platform forms the basis for a fully automated diagnostics system that is very flexible and can be customized to suit different or additional pathogens. Multiple probes on a flexible platform allow one to test probes empirically and then select highly reactive probes for further iterative evaluation. Because ECD uses an enzymatic reaction to create electrical signals that can be read directly from the array, there is no need for image analysis or for expensive and delicate optical scanning equipment. We show assay sensitivity and specificity that are excellent for a multiplexed format. C1 [Lodes, Michael J.; Suciu, Dominic; Wilmoth, Jodi L.; Ross, Marty; Munro, Sandra; Dix, Kim; Bernards, Karen; Stoever, Axel G.; Danley, David L.; McShea, Andrew] CombiMatrix Corp, Mukilteo, WA USA. [Quintana, Miguel; Iihoshi, Naomi] USA, Ctr Hlth Promot & Prevent Med W, Ft Lewis, WA USA. [Lyon, Wanda J.] USAF, Res Lab, Human Effectiveness Directorate, Appl Biotechnol Branch, Wright Patterson AFB, OH 45433 USA. RP Lodes, MJ (reprint author), CombiMatrix Corp, Mukilteo, WA USA. EM mlodes@combimatrix.com FU CombiMatrix Corporation FX This is a research and development project funded by CombiMatrix Corporation (MJL, DS, JLW, AGS, MR, SM, KD, KB, DLD, and AM). MQ and NI are employees of CHPPM-West at Fort Lewis, Washington and WJL is an employee of the US Air Force Research Laboratory, Wright-Patterson AFB, OH. NR 44 TC 37 Z9 39 U1 1 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 26 PY 2007 VL 2 IS 9 AR e924 DI 10.1371/journal.pone.0000924 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA V10HT UT WOS:000207455800004 PM 17895966 ER PT J AU Lim, SH Murakami, M Sarney, WL Ren, SQ Varatharajan, A Nagarajan, V Fujino, S Wuttig, M Takeuchi, I Salamanca-Riba, LG AF Lim, Sung Hwan Murakami, Makoto Sarney, Wendy Lynn Ren, Shen Qiang Varatharajan, Anbusathaiah Nagarajan, Valanoor Fujino, Shigehiro Wuttig, Manfred Takeuchi, Ichiro Salamanca-Riba, Lourdes G. TI The effects of multiphase formation on strain relaxation and magnetization in multiferroic BiFeO3 thin films SO ADVANCED FUNCTIONAL MATERIALS LA English DT Article ID WEAK FERROMAGNETISM; ROOM-TEMPERATURE; TRANSFORMATION; POLARIZATION AB Multiferroic epitaxial Bi-Fe-O thin films of different thicknesses (15-500 nm) were grown on SrTiO3 (001) substrates by pulsed laser deposition under various oxygen partial pressures to investigate the microstructural evolution in the Bi-Fe-O system and its effect on misfit strain relaxation and on the magnetic properties of the films. Films grown at low oxygen partial pressure show the canted antiferromagnetic phase alpha-Fe2O3 embedded in a matrix of BiFeO3, ne ferromagnetic phase, gamma-Fe2O3 is found to precipitate inside the alpha-Fe2O3 grains. The formation of these phases changes the magnetic properties of the films and the misfit strain relaxation mechanism. The multiphase films exhibit both highly strained and fully relaxed BiFeO3 regions in the same film. The magnetization in the multiphase Bi-Fe-O films is controlled by the presence of the gamma-Fe2O3 phase rather than heteroepitaxial strain as it is the case in pure single phase BiFeO3. Also, our results show that this unique accommodation of misfit strain by the formation of alpha-Fe2O3 gives rise to significant enhancement of the piezo electric properties of BiFeO3. C1 Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. Univ New S Wales, Sch Mat Sci & Engn, Sydney, NSW 2052, Australia. RP Lim, SH (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. EM shlim@umd.edu; riba@umd.edu RI Ren, Shenqiang/C-2536-2009; Salamanca-Riba, Lourdes/B-3785-2009; valanoor, nagarajan/B-4159-2012 OI Salamanca-Riba, Lourdes/0000-0001-8155-6403; NR 27 TC 26 Z9 26 U1 3 U2 36 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1616-301X J9 ADV FUNCT MATER JI Adv. Funct. Mater. PD SEP 24 PY 2007 VL 17 IS 14 BP 2594 EP 2599 DI 10.1002/adfm.200700055 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 218ME UT WOS:000250018800045 ER PT J AU Myles, O Wortmann, GW Cummings, JF Barthel, RV Patel, S Crum-Cianflone, NF Negin, NS Weina, PJ Ockenhouse, CF Joyce, DJ Magill, AJ Aronson, NE Gasser, RA AF Myles, Otha Wortmann, Glenn W. Cummings, James F. Barthel, R. Vincent Patel, Sugat Crum-Cianflone, Nancy F. Negin, Nathan S. Weina, Peter J. Ockenhouse, Christian F. Joyce, Daniel J. Magill, Alan J. Aronson, Naomi E. Gasser, Robert A., Jr. TI Visceral leishmaniasis: Clinical observations in 4 US army soldiers deployed to Afghanistan or Iraq, 2002-2004 SO ARCHIVES OF INTERNAL MEDICINE LA English DT Letter ID MEDITERRANEAN LEISHMANIASIS; RAPID DIAGNOSIS C1 Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA. RP Myles, O (reprint author), Walter Reed Army Inst Res, Div Retrovirol, 1 Taft Ct,Ste 250, Rockville, MD 20850 USA. EM omyles@hivresearch.org RI Weina, Peter/A-2120-2011 NR 13 TC 14 Z9 15 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD SEP 24 PY 2007 VL 167 IS 17 BP 1899 EP 1901 DI 10.1001/archinte.167.17.1899 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 213UR UT WOS:000249693100012 PM 17893312 ER PT J AU Ogundipe, A Braida, W Christodoulatos, C Koutsospyros, A O'Connor, G Larson, S AF Ogundipe, Adebayo Braida, Washington Christodoulatos, Christos Koutsospyros, Agamemnon O'Connor, Gregory Larson, Steven TI Comments to "Release of copper from sintered tungsten-bronze shot under different pH conditions and its potential toxicity to aquatic organisms" by Vernon Thomas, Robert Santore and Ian McGill (Science of the Total Environment 374 (2007) 71-79) SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Letter ID ALLOYS C1 Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. Univ New Haven, Civil & Environm Engn, Dept Mech, West Haven, CT 06516 USA. USA, Environm Technol Div, Picatinny Arsenal, NJ 07806 USA. USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Braida, W (reprint author), Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. EM Washington.Braida@stevens.edu NR 5 TC 3 Z9 3 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD SEP 20 PY 2007 VL 383 IS 1-3 BP 241 EP 242 DI 10.1016/j.scitotenv.2007.05.020 PG 2 WC Environmental Sciences SC Environmental Sciences & Ecology GA 202DB UT WOS:000248881100022 PM 17574653 ER PT J AU Mather, BD Baker, MB Beyer, FL Berg, MAG Green, MD Long, TE AF Mather, Brian D. Baker, Margaux B. Beyer, Frederick L. Berg, Michael A. G. Green, Matthew D. Long, Timothy E. TI Supramolecular triblock copolymers containing complementary nucleobase molecular recognition SO MACROMOLECULES LA English DT Article ID FREE-RADICAL POLYMERIZATION; HYDROGEN-BONDED COMPLEXES; BLOCK-COPOLYMERS; MICROPHASE SEPARATION; ASSOCIATION CONSTANTS; DIBLOCK COPOLYMERS; URACIL DERIVATIVES; B-C; POLYMERS; ADENINE AB A novel difunctional alkoxyamine initiator, DEPN2, was synthesized and utilized as an efficient initiator in nitroxide-mediated controlled radical polymerization of triblock copolymers. Complementary hydrogen-bonding triblock copolymers containing adenine (A) and thymine (T) nucleobase-functionalized outer blocks were synthesized. These thermoplastic elastomeric block copolymers contained short nucteobase-functionalized outer blocks (M-n similar to 1K-4K) and n-butyl acrylate rubber blocks of variable length (M-n similar to 14K-70K). Hydrogen-bonding interactions were observed for blends of the complementary nucleobase-functionalized block copolymers in terms of increased specific viscosity as well as higher scaling exponents for specific viscosity as a function of solution concentration. In the solid state, the blends exhibited evidence of a complementary A-T hard phase, which formed upon annealing, and dynamic mechanical analysis (DMA) revealed higher softening temperatures. Morphological development of the block copolymers was studied using SAXS and AFM, which revealed intermediate interdomain spacings and surface textures for the blends compared to the individual precursors. Hydrogen-bonding interactions enabled the compatibilization of complementary hydrogen-bonding guest molecules such as 9-octyladenine. C1 Virginia Polytech Inst & State Univ, Dept Chem, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA. Army Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Long, TE (reprint author), Virginia Polytech Inst & State Univ, Dept Chem, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA. EM telong@vt.edu NR 74 TC 78 Z9 78 U1 2 U2 39 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD SEP 18 PY 2007 VL 40 IS 19 BP 6834 EP 6845 DI 10.1021/ma070865y PG 12 WC Polymer Science SC Polymer Science GA 209NO UT WOS:000249395500010 ER PT J AU Brown, TR AF Brown, Theodore R. TI Emergency preparedness plan crucial for physicians and patients SO AMERICAN FAMILY PHYSICIAN LA English DT Letter C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Brown, TR (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ted.r.brown@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 15 PY 2007 VL 76 IS 6 BP 769 EP 769 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 213DD UT WOS:000249645400004 PM 17910289 ER PT J AU Song, A Shimamoto, P AF Song, Adreahna Shimamoto, Paige TI Internet-based evaluation system for a pharmacy practice residency SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Letter C1 Tripler Army Med Ctr, Dept Pharm, Honolulu, HI 96859 USA. RP Song, A (reprint author), Tripler Army Med Ctr, Dept Pharm, 1 Jarett White Rd, Honolulu, HI 96859 USA. EM adreahna.song@amedd.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD SEP 15 PY 2007 VL 64 IS 18 BP 1896 EP + DI 10.2146/ajhp060528 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 214WD UT WOS:000249768000006 PM 17823096 ER PT J AU Tennyson, H Helling, ER Wiseman, J Dick, E Lyons, RC AF Tennyson, Heath Helling, Eric R. Wiseman, Joseph Dick, Edward Lyons, Robert C. TI The effect of topical mitomycin c on full-thickness burns SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID EXPOSURES; SCALE AB Background: Burns result in substantial morbidity because of fibroblast proliferation and contracture. Mitomycin C is a chemotherapeutic agent known to suppress fibroblast proliferation. It is used in ophthalmologic disorders and reduces scarring in upper aerodigestive surgery. No study of the effect of mitomycin C on cutaneous burns has been performed. This study examined burn healing in the presence of topical mitomycin C by evaluation of wound appearance, contraction, and histology in a pig model. Methods: Standardized full-thickness burns were produced on the flanks of three pigs. One animal received no further therapy and was an external control. Two animals under-went placement of topical mitomycin C, 0.4 mg/ml, on selected burn sites for 5 minutes. This was repeated 2 and 4 weeks after injury. Evaluation was performed at 2 and 6 months using a clinical assessment scale and a visual analogue scale. Scar length and histologic analysis were also evaluated. Results: Clinical assessment scale and visual analogue scale scores showed improved appearance in the untreated external control wounds versus the untreated internal control and treated wounds (p < 0.001). Wound contraction was not significantly different between groups. Histologic characteristics between groups were similar except for epidermal hyperplasia, which was decreased in the untreated external control (p < 0.05) at 2 months after treatment. Conclusions: Topical mitomycin C treatment of full-thickness burn wounds at 0.4 mg/cc for three courses does not improve, and may worsen, clinical appearance and scarring during early healing. There is no difference in histology during the long. term healing process. Scar contraction was unchanged. C1 Univ Texas, Hlth Sci Ctr, Plast Surg Serv, San Antonio, TX USA. Ft Sam Houston, Brooke Army Med Ctr, Otolaryngol Serv, San Antonio, TX USA. Landstuhl Reg Med Ctr, Otolaryngol Serv, Landstuhl, Germany. US Army Inst Surg Res, Vet Serv, Ft Sam Houston, San Antonio, TX USA. Audie L Murphy Vet affairs Med Ctr, Plast Surg Serv, San Antonio, TX USA. RP Helling, ER (reprint author), Tripler Army Med Ctr, Plast Surg Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM eric.helling@us.army.mil NR 13 TC 5 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD SEP 15 PY 2007 VL 120 IS 4 BP 879 EP 886 DI 10.1097/01.prs.0000277666.07097.55 PG 8 WC Surgery SC Surgery GA 208XK UT WOS:000249352300008 PM 17805114 ER PT J AU Kuklo, TR Potter, BK Lenke, LG Polly, DW Sides, B Bridwell, KH AF Kuklo, Timothy R. Potter, Benjamin K. Lenke, Lawrence G. Polly, David W., Jr. Sides, Brenda Bridwell, Keith H. TI Surgical revision rates of hooks versus hybrid versus screws versus combined anteroposterior spinal fusion for adolescent idiopathic scoliosis SO SPINE LA English DT Article DE adolescent idiopathic scoliosis; instrumented spinal fusion; reoperation; complication; instrumentation failure; pseudarthrosis; infection ID COTREL-DUBOUSSET INSTRUMENTATION; THORACIC PEDICLE SCREWS; OPERATIVE SITE PAIN; HARRINGTON-INSTRUMENTATION; POSTERIOR INSTRUMENTATION; DELAYED INFECTIONS; FIXATION; MANAGEMENT; BONE; PLACEMENT AB Study Design. Multi-institution retrospective review. Objective. To determine the surgical revision rates of hook, hybrid, anteroposterior, and total pedicle screw constructs for adolescent idiopathic scoliosis (AIS). Summary of Background Data. Much debate continues on the safety, efficacy, and cost of thoracic pedicle screws. Nonetheless, there are no large series that have evaluated the revision rate of various constructs in AIS to determine the need for repeat surgery, and therefore, the added indirect costs and risks of additional procedures. Methods. We retrospectively reviewed the surgical case logs of 1428 patients with AIS at 2 institutions from 1990 to 2004, and the clinical records and radiographs of revision cases. Patients were classified into 1 of 4 groups: hook, hybrid hook and screw, all pedicle screw, and combined anteroposterior fusion constructs. Overall, there were 65 (4.6%) returns to the operating room, or 55 (3.9%) cases after excluding infections without concomitant pseudarthrosis. Results. Of the 65 revision cases, there were 52 females and 13 males, at an average age at first surgery of 13.9 years (range, 9-18 years), and an average age at revision of 14.7 years (range, 12-23 years). For the revision cases, the average initial Cobb was 61.9 degrees (range 44 degrees-100 degrees), and this was not statistically different within the cohorts (P > 0.05). In terms of revision rate, all hook constructs had a higher revision rate secondary to instrumentation failure when compared with screws, while both hook and hybrid constructs had an overall higher surgical revision rate when compared with screw constructs or anteroposterior constructs (all P <= 0.05). The pseudarthrosis rate trended toward, but did not meet, statistical significance between these same groups. Conclusion. All pedicle screw and anteroposterior constructs have a lower surgical revision rate when compared with hook and hybrid constructs. The hidden patient and financial costs of these findings should be considered when evaluating overall instrumentation efficacy. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Shriners Hosp Children, St Louis, MO USA. Washington Univ, Sch Med, Dept Orthopaed Surg & Pediat & Adult Spinal Surg, St Louis, MO USA. Univ Minnesota, Dept Orthopaed Surg, Spine Serv, Minneapolis, MN USA. Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA. Washington Univ, Sch Med, Spine Fellowship Program, Dept Orthopaed Surg, St Louis, MO USA. RP Kuklo, TR (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave NW,Bldg 2,Clin 5A, Washington, DC 20307 USA. EM kuklot@wudosis.wustl.edu NR 52 TC 61 Z9 69 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD SEP 15 PY 2007 VL 32 IS 20 BP 2258 EP 2264 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 212FZ UT WOS:000249580300017 PM 17873820 ER PT J AU Earl, PL Americo, JL Wyatt, LS Eller, LA Montefiori, DC Byrum, R Piatak, M Lifson, JD Amara, RR Robinson, HL Huggins, JW Moss, B AF Earl, Patricia L. Americo, Jeffrey L. Wyatt, Linda S. Eller, Leigh Anne Montefiori, David C. Byrum, Russ Piatak, Michael Lifson, Jeffrey D. Amara, Rama Rao Robinson, Harriet L. Huggins, John W. Moss, Bernard TI Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate SO VIROLOGY LA English DT Article DE SHIV/89.6P; recombinant modified vaccinia virus Ankara; monkeypox virus; smallpox; rhesus macaque ID CYTOTOXIC T-LYMPHOCYTES; RHESUS-MONKEYS; GAG-POL; SMALLPOX VACCINE; IN-VIVO; CYNOMOLGUS MONKEYS; MUCOSAL CHALLENGE; IMMUNOGENICITY; MACAQUES; MVA AB Recombinant and non-recombinant modified vaccinia virus Ankara (MVA) strains are currently in clinical trials as human immunodeficiency virus-1 (HIV) and attenuated smallpox vaccines, respectively. Here we tested the ability of a recombinant MVA delivered by alternative needlefree routes (intramuscular, intradennal, or into the palatine tonsil) to protect against immunodeficiency and orthopoxvirus diseases in a non-human primate model. Rhesus macaques were immunized twice I month apart with MVA expressing 5 genes from a pathogenic simian human immunodeficiency virus (SHIV)/89.6P and challenged intrarectally 9 months later with the pathogenic SHIV/89.6P and intravenously 2.7 years later with monkeypox virus. Irrespective of the route of vaccine delivery, binding and neutralizing antibodies and CD8 responses to SHIV and orthopoxvirus proteins were induced and the monkeys were successively protected against the diseases caused by the challenge viruses in unimmunized controls as determined by viral loads and clinical signs. These non-human primate studies support the clinical testing of recombinant MVA as an HIV vaccine and further demonstrate that MVA can provide long-term poxvirus immunity, essential for use as an alternative smallpox vaccine. (c) 2007 Elsevier Inc. All rights reserved. C1 Natl Inst Hlth, NIAID, Viral Dis Lab, Bethesda, MD 20892 USA. Henry M Jackson Fdn, Rockville, MD 20852 USA. Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. Bioqual, Rockville, MD 20850 USA. Natl Canc Inst, AIDS Vaccine Program, Sci Appl Int Corp, Ft Detrick, MD 21702 USA. Emory Univ, Yerkes Natl Primate Res Ctr, Vaccine Res Ctr, Dept Microbiol Immunol, Atlanta, GA 30329 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Earl, PL (reprint author), Natl Inst Hlth, NIAID, Viral Dis Lab, Bldg 33,Room 1E19,33 N Dr, Bethesda, MD 20892 USA. EM pearl@niaid.nih.gov FU Intramural NIH HHS [Z01 AI000416-24] NR 62 TC 34 Z9 35 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD SEP 15 PY 2007 VL 366 IS 1 BP 84 EP 97 DI 10.1016/j.virol.2007.02.041 PG 14 WC Virology SC Virology GA 209VA UT WOS:000249414900010 PM 17499326 ER PT J AU George, SZ Childs, JD Teyhen, DS Wu, SS Wright, AC Dugan, JL Robinson, ME AF George, Steven Z. Childs, John D. Teyhen, Deydre S. Wu, Samuel S. Wright, Alison C. Dugan, Jessica L. Robinson, Michael E. TI Rationale, design, and protocol for the prevention of low back pain in the military (POLM) trial (NCT00373009) SO BMC MUSCULOSKELETAL DISORDERS LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; BECK DEPRESSION INVENTORY; LUMBAR MULTIFIDUS MUSCLE; FEAR-AVOIDANCE BELIEFS; UPPER-LIMB MOVEMENT; TRANSVERSUS ABDOMINIS; PHYSICAL IMPAIRMENT; SCIENTIFIC EVIDENCE; GENERAL-POPULATION; DISABILITY BEGINS AB Background: There are few effective strategies reported for the primary prevention of low back pain (LBP). Core stabilization exercises targeting the deep abdominal and trunk musculature and psychosocial education programs addressing patient beliefs and coping styles represent the current best evidence for secondary prevention of low back pain. However, these programs have not been widely tested to determine if they are effective at preventing the primary onset and/or severity of LBP. The purpose of this cluster randomized clinical trial is to determine if a combined core stabilization exercise and education program is effective in preventing the onset and/or severity of LBP. The effect of the combined program will be compared to three other standard programs. Methods/Design: Consecutive Soldiers participating in advanced individual training (AIT) will be screened for eligibility requirements and consented to study participation, as appropriate. Companies of Soldiers will be randomly assigned to receive the following standard prevention programs; a core stabilization exercise program (CSEP) alone, a CSEP with a psychosocial education (PSEP), a traditional exercise (TEP), or a TEP with a PSEP. Proximal outcome measures will be assessed at the conclusion of AIT (a 12 week training period) and include imaging of deep lumbar musculature using real-time ultrasound imaging and beliefs about LBP by self-report questionnaire. We are hypothesizing that Soldiers receiving the CSEP will have improved thickness of selected deep lumbar musculature (transversus abdominus, multifidi, and erector spinae muscles). We are also hypothesizing that Soldiers receiving the PSEP will have improved beliefs about the management of LBP. After AIT, Soldiers will be followed monthly to measure the distal outcomes of LBP occurrence and severity. This information will be collected during the subsequent 2 years following completion of AIT using a web-based data entry system. Soldiers will receive a monthly email that queries whether any LBP was experienced in the previous calendar month. Soldiers reporting LBP will enter episode-specific data related to pain intensity, pain-related disability, fear-avoidance beliefs, and pain catastrophizing. We are hypothesizing that Soldiers receiving the CSEP and PSEP will report the longest duration to first episode of LBP, the lowest frequency of LBP, and the lowest severity of LBP episodes. Statistical comparisons will be made between each of the randomly assigned prevention programs to test our hypotheses related to determining which of the 4 programs is most effective. Discussion: We have presented the design and protocol for the POLM trial. Completion of this trial will provide important information on how to effectively train Soldiers for the prevention of LBP. C1 Univ Florida, Brooks Ctr Rehabil Studies, Dept P hys Therapy, Gainesville, FL 32610 USA. Baylor Univ, USA, Doctoral Program Phys Therapy MCCS HMT, Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. Univ Florida, Dept Epidemiol & Hlth Policy Res, Gainesville, FL 32610 USA. Univ Florida, Ctr Pain Res & Behav Hlth, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA. RP George, SZ (reprint author), Univ Florida, Brooks Ctr Rehabil Studies, Dept P hys Therapy, POB 100154, Gainesville, FL 32610 USA. EM sgeorge@phhp.ufl.edu; childsjd@sbcglobal.net; dteyhen@sbcglobal.net; samwu@biostat.ufl.edu; alison.wright@us.army.mil; jessie@evidenceinmotion.com; merobin@ufl.edu NR 86 TC 18 Z9 19 U1 1 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2474 J9 BMC MUSCULOSKEL DIS JI BMC Musculoskelet. Disord. PD SEP 14 PY 2007 VL 8 AR 92 DI 10.1186/1471-2474-8-92 PG 11 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA 225QG UT WOS:000250531800001 PM 17868436 ER PT J AU Santanello, JA Peters-Lidard, CD Garcia, ME Mocko, DM Tischler, MA Moran, MS Thoma, DP AF Santanello, Joseph A., Jr. Peters-Lidard, Christa D. Garcia, Matthew E. Mocko, David M. Tischler, Michael A. Moran, M. Susan Thoma, D. P. TI Using remotely-sensed estimates of soil moisture to infer soil texture and hydraulic properties across a semi-arid watershed SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE parameter estimation; soil moisture; active microwave; passive microwave; PBMR; land surface modeling; model calibration; soil hydraulic; properties; temporal sampling; watershed modeling; soil type; pedotransfer functions ID LAND-SURFACE MODEL; BOUNDARY-LAYER; PEDOTRANSFER FUNCTIONS; DATA ASSIMILATION; ETA-MODEL; CONDUCTIVITY; PARAMETERS; SIMULATION; ENERGY; FLOW AB Near-surface soil moisture is a critical component of land surface energy and water balance studies encompassing a wide range of disciplines. However, the processes of infiltration, runoff, and evapotranspiration in the vadose zone of the soil are not easy to quantify or predict because of the difficulty in accurately representing soil texture and hydraulic properties in land surface models. This study approaches the problem of parameterizing soil properties from a unique perspective based on components originally developed for operational estimation of soil moisture for mobility assessments. Estimates of near-surface soil moisture derived from passive (L-band) microwave remote sensing were acquired on six dates during the Monsoon '90 experiment in southeastern Arizona, and used to calibrate hydraulic properties in an offline land surface model and infer information on the soil conditions of the region. Specifically, a robust parameter estimation tool (PEST) was used to calibrate the Noah land surface model and run at very high spatial resolution across the Walnut Gulch Experimental Watershed. Errors in simulated versus observed soil moisture were minimized by adjusting the soil texture, which in turn controls the hydraulic properties through the use of pedotransfer functions. By estimating within a continuous range of widely applicable soil properties such as sand, silt, and clay percentages rather than applying rigid soil texture classes, lookup tables, or large parameter sets as in previous studies, the physical accuracy and consistency of the resulting soils could then be assessed. In addition, the sensitivity of this calibration method to the number and timing of microwave retrievals is determined in relation to the temporal patterns in precipitation and soil drying. The resultant soil properties were applied to an extended time period demonstrating the improvement in simulated soil moisture over that using default or county-level soil parameters. The methodology is also applied to an independent case at Walnut Gulch using a new soil moisture product from active (C-band) radar imagery with much lower spatial and temporal resolution. Overall, results demonstrate the potential to gain physically meaningful soil information using simple parameter estimation with few but appropriately timed remote sensing retrievals. (c) 2007 Elsevier Inc. All rights reserved. C1 UMCP, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD USA. NASA, Goddard Space Flight Ctr, Hydrol Sci Branch, Greenbelt, MD 20771 USA. Sci Applicat Int Corp, Mclean, VA 22102 USA. USA, Ctr Res Dev & Engn, TEC, Alexandria, VA USA. USDA ARS, SW Watershed Res Ctr, Tucson, AZ USA. UMBC, Goddard Earth Sci & Technol Ctr, Baltimore, MD USA. RP Santanello, JA (reprint author), UMCP, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD USA. EM sntnello@hsb.gsfc.nasa.gov RI Santanello, Joseph/D-4438-2012; Garcia, Matthew/K-9286-2013; Peters-Lidard, Christa/E-1429-2012 OI Santanello, Joseph/0000-0002-0807-6590; Garcia, Matthew/0000-0002-9637-4204; Peters-Lidard, Christa/0000-0003-1255-2876 NR 69 TC 70 Z9 73 U1 2 U2 30 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD SEP 14 PY 2007 VL 110 IS 1 BP 79 EP 97 DI 10.1016/j.rse.2007.02.007 PG 19 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 198PJ UT WOS:000248639700006 ER PT J AU Djie, HS Tan, CL Ooi, BS Hwang, JCM Fang, XM Wu, Y Fastenau, JM Liu, WK Dang, GT Chang, WH AF Djie, H. S. Tan, C. L. Ooi, B. S. Hwang, J. C. M. Fang, X.-M. Wu, Y. Fastenau, J. M. Liu, W. K. Dang, G. T. Chang, W. H. TI Ultrabroad stimulated emission from quantum-dash laser SO APPLIED PHYSICS LETTERS LA English DT Article AB The authors demonstrate the generation of ultrabroadband stimulated emission in the quasi-zero-dimensional InAs/InAlGaAs quantum-dash laser grown on InP substrate. The laser exhibits lasing wavelength coverage of up to 76 nm at similar to 1.64 mu m from simultaneous multiple confined states lasing at room temperature. Unlike the conventional interband diode laser, the rule changing broadband lasing signature is achieved from the quasicontinuous interband transition formed by the inhomogeneous quantum-dash nanostructure. C1 Lehigh Univ, Ctr Opt Technol, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. IQE Inc, Bethlehem, PA 18015 USA. Army Res Lab, Adelphi, MD USA. JDS Uniphase Corp, San Jose, CA 95134 USA. RP Djie, HS (reprint author), Lehigh Univ, Ctr Opt Technol, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. EM hery@ieee.org; bsooi@lehigh.edu RI Ooi, Boon/D-4370-2011 OI Ooi, Boon/0000-0001-9606-5578 NR 6 TC 35 Z9 35 U1 2 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 10 PY 2007 VL 91 IS 11 AR 111116 DI 10.1063/1.2784969 PG 3 WC Physics, Applied SC Physics GA 210RT UT WOS:000249474000016 ER PT J AU Warrender, JM Mulligan, CP Underwood, JH AF Warrender, J. M. Mulligan, C. P. Underwood, J. H. TI Analysis of thermo-mechanical cracking in refractory coatings using variable pulse-duration laser pulse heating SO WEAR LA English DT Article DE refractory coatings; cannon firing; laser pulse heating; crack formation ID GUN BORE COATINGS AB Large caliber cannon firing represents a unique and demanding environment, characterized by a transient surface temperature spike of about 1500 K over about 2 ms. Design and evaluation of protective coatings that can withstand this intense thermal loading without thermo-mechanical failure and wear is an ongoing process, but live-fire tests to assess coating performance are difficult and expensive. Previous studies demonstrated that Cr and Ta coatings irradiated with a pulsed laser with a 5 ms pulse duration exhibited morphological features comparable to those observed in cannons. including recrystallization and grain growth of Cr, crack formation, a phase transition in the substrate steel, interface degradation, and chemical reactions in the steel [PT Cote, G. Kendall, M.E. Todaro, Laser pulse heating of gun bore coatings, Surf. Coat. Tech. 146-147 (2001) 65-69: P.J. Cote, M.E. Todaro, G. Kendall, M. Witherell, Gun bore erosion mechanisms revisited with laser pulse heating, Surf. Coat. Tech. 163-164 (2003) 478-483]. However, the laser was unable to induce the types of adhesive failures that accelerate wear and erosion in coatings that were subsequently observed to fail in this manner during live fire testing. The recent acquisition of a variable-pulse duration Nd:YAG laser, which allows a pulse duration as low as 0.5 ms, has resulted in initiation of coating adhesive failure in much better agreement with live fire tests. The variable pulse duration enables study of the varied thermal loading and the resulting wear and erosion behavior experienced by the cannon bore at various locations, which improves the fidelity of the laser test. The ability to independently vary the fluence supplied to the coating and the pulse duration affords insight into the processes leading to thermally induced wear and erosion. Finite-difference calculations of the heat flow in the coatings are presented to explain the temporal and depth-resolved temperature profile in the coating, and the implications of this profile for coating wear in thermal transient environments are discussed. (c) 2007 Published by Elsevier B.V. C1 US Army Benet Labs, Launcher Technol Div, Watervliet, NY 12189 USA. US Army Benet Labs, Battelle Sci Serv, Watervliet, NY 12189 USA. RP Warrender, JM (reprint author), US Army Benet Labs, Launcher Technol Div, Watervliet, NY 12189 USA. EM jeffrey.warrender@us.amiy.mil NR 4 TC 6 Z9 7 U1 2 U2 5 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0043-1648 J9 WEAR JI Wear PD SEP 10 PY 2007 VL 263 SI SI BP 1540 EP 1544 DI 10.1016/j.wear.2007.02.017 PN 2 PG 5 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 214QZ UT WOS:000249754500089 ER PT J AU Underwood, JH Vigilante, GN Mulligan, CP AF Underwood, J. H. Vigilante, G. N. Mulligan, C. P. TI Review of thermo-mechanical cracking and wear mechanisms in large caliber guns SO WEAR LA English DT Review DE thermo-mechanical cracks; cannon firings erosion; thermal barrier coatings; ceramics ID THERMAL-DAMAGE; BORE COATINGS; EROSION AB Thermo-mechanical cracking has become a critical wear mechanism in modern large caliber guns, due to operational increases in severity of heating at the gun bore in order to increase gun performance. The chromium coating typically used in guns often cracks after one firing, as do tantalum coatings and ceramic liners being considered for future guns. Once small segments of coating are surrounded by cracks, rapid erosion failure is likely. In prior studies to address this problem, models have described the depth and spacing of thermal cracks that develop in bore coatings and identified the mechanism of final separation of a cracked segment of coating. The models have used finite difference calculations of near-bore temperatures and elevated temperature material properties to calculate the thermal expansion stresses which cause both the initial cracking and the final separation of a cracked segment of bore material. The current work will review prior and recent observed damage and the models developed to describe the damage, and then extend the models to a wider range of gun firing conditions and materials from recent tests. Included will be [i] recent firing damage in tantalum coated steel liners in 120 mm inner diameter guns, [ii] additional recent gun-combustion simulation of firing damage in a SiAlON bulk ceramic, and [iii] extension of thermo-mechanical and fracture models showing effects of transient cannon heating and different coating materials on the near-bore temperatures and stresses that control both initial crack formation and final segment separation. Published by Elsevier B.V. C1 USA, Benet Labs, Battelle Sci Serv, Watervliet, NY 12189 USA. USA, Benet Labs, Launcher Technol Div, Watervliet, NY 12189 USA. RP Underwood, JH (reprint author), USA, Benet Labs, Battelle Sci Serv, Watervliet, NY 12189 USA. EM john.h.underwood@us.army.mil NR 10 TC 13 Z9 17 U1 3 U2 10 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0043-1648 J9 WEAR JI Wear PD SEP 10 PY 2007 VL 263 SI SI BP 1616 EP 1621 DI 10.1016/j.wear.2006.12.005 PN 2 PG 6 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 214QZ UT WOS:000249754500101 ER PT J AU Cable, S Lin, Y Holloway, JL AF Cable, S. Lin, Y. Holloway, J. L. TI Intermediate shocks in three-dimensional magnetohydrodynamic bow-shock flows with multiple interacting shock fronts SO JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS LA English DT Article ID CORONAL MASS EJECTIONS; MHD SIMULATIONS; SLOW SHOCKS AB Previous MHD simulations predict that when switch-on shock conditions obtain in the solar wind, the bow shock produced in front of an ellipsoidal obstacle will produce a unique bow shock configuration that includes a concave intermediate shock region at the nose of the shock. These simulations have been carried out with hard shell inner boundary conditions. We extend these studies by investigating the configuration of the bow shock when the obstacle is a terrestrial magnetic dipole field. It is found that, in contrast to the typical fast shock, reconnection at the magnetosphere affects the structure of the upstream magnetosheath and bow shock considerably. Asymmetry in magnetic reconnection rates between the northern and southern hemispheres changes the bow shock configuration notably. In the hemisphere where the dipole field is largely antiparallel to the interplanetary magnetic field, the intermediate shock is eliminated in favor of a standard fast shock. In the other hemisphere, however, the intermediate shock still forms as an important, stable element of the overall shock configuration. We also launch a solar wind MHD fast shock into the simulation domain and observe how the resulting waves transmit and reflect in the magnetosheath and magnetosphere and how the general morphology of the bow shock changes. C1 USA, Corps Engineers, Ctr Res Dev & Engn, Major Shared Resource Ctr, Vicksburg, MS 39180 USA. Auburn Univ, Dept Phys, Auburn, AL 36849 USA. Mississippi State Univ, Dept Mech Engn, Starkville, MS USA. RP Cable, S (reprint author), USA, Corps Engineers, Ctr Res Dev & Engn, Major Shared Resource Ctr, Vicksburg, MS 39180 USA. EM sam.b.cable@erdc.usace.army.mil; ylin@physics.auaburn.edu; jlh530@msstate.edu NR 18 TC 8 Z9 8 U1 2 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-SPACE JI J. Geophys. Res-Space Phys. PD SEP 8 PY 2007 VL 112 IS A9 AR A09202 DI 10.1029/2007JA012419 PG 8 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 209FE UT WOS:000249373600011 ER PT J AU Bacon, DJ Jambou, R Fandeur, T Le Bras, J Wongsrichanalai, C Fukuda, MM Ringwald, P Sibley, CH Kyle, DE AF Bacon, David J. Jambou, Ronan Fandeur, Thierry Le Bras, Jacques Wongsrichanalai, Chansuda Fukuda, Mark M. Ringwald, Pascal Sibley, Carol Hopkins Kyle, Dennis E. TI World antimalarial resistance network (WARN) II: In vitro antimalarial drug susceptibility SO MALARIA JOURNAL LA English DT Review ID PARASITE PLASMODIUM-FALCIPARUM; LINKED-IMMUNOSORBENT-ASSAY; RICH PROTEIN-II; MOLECULAR EPIDEMIOLOGY; MALARIA PARASITES; ARTEMETHER-LUMEFANTRINE; CHLOROQUINE RESISTANCE; LACTATE-DEHYDROGENASE; SENSITIVITY; CAMEROON AB Intrinsic resistance of Plasmodium falciparum is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ability to define parasite drug resistance in vivo. The in vitro antimalarial drug susceptibility assay determines ex-vivo growth of parasite in the presence of serial drug concentrations and, thus, eliminates host effects, such as drug metabolism and immunity. Although the sensitivity of the parasite to various antimalarials provided by such a test provides an important indicator of intrinsic parasite susceptibility, there are fundamental methodological issues that undermine comparison of in vitro susceptibility both between laboratories and within a single laboratory over time. A network of laboratories is proposed that will agree on the basic parameters of the in vitro test and associated measures of quality control. The aim of the network would be to establish baseline values of sensitivity to commonly used antimalarial agents from key regions of the world, and create a global database, linked to clinical, molecular and pharmacology databases, to support active surveillance to monitor temporal trends in parasite susceptibility. Such a network would facilitate the rapid detection of strains with novel antimalarial resistance profiles and investigate suitable alternative treatments with retained efficacy. C1 Naval Med Res Ctr Detachment, Parasitol Program, Lima, Peru. Inst Pasteur, Lab Immunol Clin & Parasitaire, Dakur, Senegal. Inst Pasteur, Unite Immunol Mol Parasites, Paris, France. Hop Bichat Claude Bernard, F-75877 Paris 18, France. USN, Med Res Unit 2, NAMRU 2, Jakarta, Indonesia. Armed Forces Res Inst Med Sci, USA Med Component, Dept Immunol & Med, Bangkok 10400, Thailand. WHO, Global Malaria Program, CH-1211 Geneva 27, Switzerland. Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. Univ S Florida, Coll Publ Hlth, Dept Global Hlth, Tampa, FL USA. RP Bacon, DJ (reprint author), Naval Med Res Ctr Detachment, Parasitol Program, Lima, Peru. EM bacon@nmrcd.med.navy.mil; rjambou@pasteur.sn; tfandeur@pasteur.fr; jacques.lebras@gmail.com; dr.chansuda@gmail.com; Mark.Fukuda@afrims.org; ringwaldp@who.int; sibley@u.washington.edu; dkyle@health.usf.edu NR 44 TC 34 Z9 34 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD SEP 6 PY 2007 VL 6 AR 120 DI 10.1186/1475-2875-6-120 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 224RH UT WOS:000250463600002 PM 17822533 ER PT J AU Feigin, DS Magid, D Smirniotopoulos, JG Carbognin, SJ AF Feigin, David S. Magid, Donna Smirniotopoulos, James G. Carbognin, Susan Jennifer TI Learning and retaining normal radiographic chest anatomy: Does preclinical exposure improve student performance? SO ACADEMIC RADIOLOGY LA English DT Article DE radiology education; medical student teaching; radiologic anatomy; chest imaging; learning theory ID MEDICAL-STUDENTS; RADIOLOGY; EDUCATION; CURRICULUM; RETENTION AB Rationale and Objectives. Although most would concur that preclinical exposure to radiology is a desirable goal, specific learning objectives have been more difficult to delineate. It is also important to assess what is learned and to determine how well it is retained or "retrievable." This study was developed in an attempt to document the extent to which specific measures of preclinically acquired knowledge may be retained and retrieved for later clinical application. Material and Methods. The Anatomic Structure Identification Quiz (ASIQ, or Quiz), previously described in Feigin et al (Academic Radiology ? 2005) was administered to 236 medical students at the conclusion of the required second-year course. as a 10-item written Quiz based on a projected frontal and lateral chest image. The 10-item Quiz was also administered to 555 senior medical students (194 of which had been included in previous work) on the first day of the Uniformed Services University of the Health Sciences basic radiology elective. Finally, the identical Quiz was completed by 74 of these 555 senior medical students at the conclusion of the academic portion of the elective, approximately 3 weeks after the administration of the first quiz. Results. The second-year students scored a mean of 7.15 points of a possible 10 points with a standard deviation (SD) of 1.42. The senior students completing the quiz at the beginning of the elective scored an average of 4.42 (SD 1.34) compared to a score of 8.65 (SD 1.24) 3 weeks later. Conclusion. Long-term recall of specific radiologic structures learned in the second year of medical school was poor despite evidence documenting good initial (short-term) retention of tested information. However, after a brief review, consisting of the Quiz itself, followed by 3 weeks of general radiology emphasizing abnormal chest imaging, the senior students demonstrated a near doubling of their ability to correctly identify these structures, as well as an improvement compared with scores obtained during the second year. Thus the value of a preclinical course in radiology may be not only to teach principles of radiology and to stimulate interest in the discipline, but also, by repetition and reinforcement, to facilitate and possibly improve later recall and retention of important radiographic material. C1 Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Magid, D (reprint author), Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, 601 N Caroline St, Baltimore, MD 21287 USA. EM dmagid@jhmi.edu RI Smirniotopoulos, James/D-3726-2011 NR 14 TC 19 Z9 19 U1 2 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1076-6332 J9 ACAD RADIOL JI Acad. Radiol. PD SEP PY 2007 VL 14 IS 9 BP 1137 EP 1142 DI 10.1016/j.acra.2007.06.023 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 205RX UT WOS:000249133400018 PM 17707323 ER PT J AU Hammers, DW Matheny, W Adamo, M Walters, T Farrar, RP AF Hammers, David W. Matheny, Wayne Adamo, Martin Walters, Thomas Farrar, Roger P. TI Age-related changes in insulin-like growth factor-I in ischemia/reperfusion injured skeletal muscle SO AGE LA English DT Meeting Abstract C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX 78284 USA. USA, Inst Surg Res, Soft Tissue Injury Lab, Ft Sam Houston, TX 78234 USA. Univ Texas, Austin, TX 78712 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0161-9152 J9 AGE JI Age PD SEP PY 2007 VL 29 IS 2-3 BP 107 EP 108 PG 2 WC Geriatrics & Gerontology SC Geriatrics & Gerontology GA 201KK UT WOS:000248829900016 ER PT J AU Ally, MR Veerappan, GR Pak, JS Maydonovitch, CL Choi, JHR Wong, RKH AF Ally, Mazer R. Veerappan, Ganesh R. Pak, Jennifer S. Maydonovitch, Corinne L. Choi, Jong-Ho R. Wong, Roy K. H. TI CT colonography (CTC) reporting and data system (CRADS): An effective method to manage extracolonic (EC) findings SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 72nd Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 12-17, 2007 CL Philadelphia, PA SP Amer Coll Gastroengerol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2007 VL 102 SU 2 MA 1223 BP S565 EP S565 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 209OL UT WOS:000249397801216 ER PT J AU Bassett, JT Perry, JL Osgard, EM Maydonovitch, CL Sobin, LH Wong, RH AF Bassett, John T. Perry, Joseph L. Osgard, Eric M. Maydonovitch, Corinne L. Sobin, Leslie H. Wong, Ray H. TI Prevalence of esophageal dysmotility in a cohort of patients with biopsy proven eosinophilic esophagitis. A prospective study SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 72nd Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 12-17, 2007 CL Philadelphia, PA SP Amer Coll Gastroengerol C1 Natl Naval Med Ctr, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2007 VL 102 SU 2 BP S121 EP S121 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 209OL UT WOS:000249397800009 ER PT J AU Paredes, AH Nguyen, VNH Maydonovitch, CL AF Paredes, Angelo H. Nguyen, Viet-Nhan H. Maydonovitch, Corrine L. TI Utility of screening coagulation studies in gastrointestinal bleeding patients without risk factors for coagulopathy admitted to the intensive care unit SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 72nd Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 12-17, 2007 CL Philadelphia, PA SP Amer Coll Gastroengerol C1 Walter Reed Army Med Ctr, Dept Gastroenterol, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2007 VL 102 SU 2 MA 888 BP S445 EP S445 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 209OL UT WOS:000249397800886 ER PT J AU Veerappan, GR Koff, JM Smith, MT AF Veerappan, Ganesh R. Koff, Jonathan M. Smith, Milton T. TI Enteryx: Migration into the lymphatics and beyond SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 72nd Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 12-17, 2007 CL Philadelphia, PA SP Amer Coll Gastroengerol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2007 VL 102 SU 2 MA 758 BP S396 EP S397 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 209OL UT WOS:000249397800756 ER PT J AU Veerappan, GR Wakefield, MC Aidnian, G Osgard, EM AF Veerappan, Ganesh R. Wakefield, Matthew C. Aidnian, Gilbert Osgard, Eric M. TI Gallbladder remnant: Rare cause of abdominal pain post cholecystectomy SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 72nd Annual Scientific Meeting of the American-College-of-Gastroenterology CY OCT 12-17, 2007 CL Philadelphia, PA SP Amer Coll Gastroengerol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2007 VL 102 SU 2 MA 472 BP S289 EP S289 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 209OL UT WOS:000249397800470 ER PT J AU Abbott, KC Neff, RT Bohen, EM Narayan, R AF Abbott, Kevin C. Neff, Robert T. Bohen, Erin M. Narayan, Rajeev TI Anticoagulation for chronic atrial fibrillation in hemodialysis patients: Which fruit from the decision tree? SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Editorial Material ID GRAFT THROMBOSIS; CONTROLLED TRIAL; RISK-FACTORS; DOUBLE-BLIND; STROKE; PREVENTION; PREVALENCE; MANAGEMENT; THERAPY; RHYTHM C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. William Beaumont Army Med Ctr, Ft Bliss, TX USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, 6900 Georgia Ave, Washington, DC 20307 USA. EM kevin.abbott@amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 18 TC 9 Z9 9 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD SEP PY 2007 VL 50 IS 3 BP 345 EP 348 DI 10.1053/j.ajkd.2007.07.004 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 206YR UT WOS:000249219300002 PM 17720510 ER PT J AU Gleeson, TD Decker, CF Johnson, MD Hartzell, JD Mascola, JR AF Gleeson, Todd D. Decker, Catherine F. Johnson, Mark D. Hartzell, Joshua D. Mascola, John R. TI Q fever in US military returning from Iraq SO AMERICAN JOURNAL OF MEDICINE LA English DT Letter C1 Natl Naval Med Ctr, Div Infect Dis, Dept Internal Med, Bethesda, MD 20899 USA. Walter Reed Army Med Ctr, Div Infect Dis, Dept Internal Med, Washington, DC 20307 USA. NIAID, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. RP Gleeson, TD (reprint author), Natl Naval Med Ctr, Div Infect Dis, Dept Internal Med, 8901 Wisconsin Ave, Bethesda, MD 20899 USA. EM tdgleeson@bethesda.med.navy.mil NR 4 TC 12 Z9 12 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9343 J9 AM J MED JI Am. J. Med. PD SEP PY 2007 VL 120 IS 9 BP E11 EP E12 DI 10.1016/j.amjmed.2007.03.020 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 205ON UT WOS:000249123800025 PM 17765028 ER PT J AU Sripipatana, T Spensley, A Miller, A McIntyre, J Sangiwa, G Sawe, F Jones, D Wilfert, CM AF Sripipatana, Tabitha Spensley, Allison Miller, Anna McIntyre, James Sangiwa, Gloria Sawe, Frederick Jones, David Wilfert, Catherine M. TI Site-specific interventions to improve prevention of mother-to-child transmission of human immunodeficiency virus programs in less developed settings SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE human immunodeficiency virus; prevention of mother-to-child transmission; resource-constrained settings ID HIV-1 TRANSMISSION; PREGNANT-WOMEN; COUNTRIES; INFANT AB This article reviews the experiences of programs designed to provide access to prevention of mother-to-child transmission services with the goal of improving services in resource-constrained settings. The article reports new data from the Elizabeth Glaser Pediatric AIDS Foundation's prevention of mother-to-child transmission program in sub-Saharan Africa, which has provided human immunodeficiency virus testing to more than 1,300,000 pregnant women and antiretroviral prophylaxis to 134,000 human immunodeficiency virus-infected pregnant women and more than 78,000 human immunodeficiency virus-exposed infants. Review of qualitative program data highlights the practical innovations that sites are implementing to improve the uptake of prevention of mother-to-child transmission services. Recommendations discussed include opt-out counseling and testing, rapid human immunodeficiency virus testing in antenatal care, counseling and testing in maternity, and provision of antiretroviral prophylaxis for mother and infant at the time of human immunodeficiency virus testing. Successful programmatic innovations need to be disseminated widely as more aggressive prevention strategies must be implemented to increase access to more than 10% of pregnant women worldwide. C1 Elizabeth Glaser Pediat AIDS Fdn, Washington, DC USA. Univ Witwatersrand, Johannesburg, South Africa. Family Hlth Int, Arlington, VA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Baylor Coll Med, Houston, TX 77030 USA. RP Sripipatana, T (reprint author), Elizabeth Glaser Pediat AIDS Fdn, Washington, DC USA. NR 26 TC 27 Z9 27 U1 0 U2 7 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD SEP PY 2007 VL 197 IS 3 SU 1 BP S107 EP S112 DI 10.1016/ajog.2007.03.069 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 212GR UT WOS:000249582700015 PM 17825641 ER PT J AU Chew, FS Bui-Mansfield, LT AF Chew, Felix S. Bui-Mansfield, Liem T. TI Imaging popliteal artery disease in young adults with claudication: self-assessment module SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE claudication; cystic adventitial disease; popliteal artery disease; popliteal artery entrapment syndrome ID CYSTIC ADVENTITIAL DISEASE; ENTRAPMENT; DIAGNOSIS AB The educational objectives of this self-assessment module on imaging popliteal artery disease in young adults with intermittent claudication are for the participant to exercise, self-assess, and improve his or her knowledge of the imaging and clinical features of popliteal artery entrapment syndrome, cystic adventitial disease, and masses associated with popliteal artery obstruction. C1 Univ Washington, Dept Radiol, Seattle, WA 98105 USA. Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. RP Chew, FS (reprint author), Univ Washington, Dept Radiol, Box 354755,4245 Roosevelt Way NE, Seattle, WA 98105 USA. EM fchew@u.washington.edu OI Chew, Felix/0000-0003-2711-2013 NR 5 TC 0 Z9 0 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2007 VL 189 IS 3 SU S BP S13 EP S16 DI 10.2214/AJR.07.7020 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 205FQ UT WOS:000249099800003 PM 19642256 ER PT J AU Sutcliffe, JB Bui-Mansfield, LT AF Sutcliffe, Joseph B., III Bui-Mansfield, Liem T. TI AJR teaching file: Intermittent claudication of the lower extremity in a young patient SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE claudication; femur; osteochondroma; peripheral vascular disease ID POPLITEAL ARTERY ENTRAPMENT; FIBROMUSCULAR DYSPLASIA; OSTEOCHONDROMA; DISEASE; ANGIOGRAPHY; DIAGNOSIS C1 Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. RP Sutcliffe, JB (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM joseph.sutcliffe@amodd.army.mil NR 15 TC 3 Z9 3 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2007 VL 189 IS 3 SU S BP S17 EP S20 DI 10.2214/AJR.06.0398 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 205FQ UT WOS:000249099800004 PM 17715070 ER PT J AU Garrison, AR Alakbarova, S Kulesh, DA Shezmukhamedova, D Khodjaev, S Endy, TP Paragas, J AF Garrison, A. R. Alakbarova, S. Kulesh, D. A. Shezmukhamedova, D. Khodjaev, S. Endy, T. P. Paragas, J. TI Development of a TaqMan((R))-Minor groove binding protein assay for the detection and quantification of crimean-congo hemorrhagic fever virus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TIME RT-PCR; EXPERIMENTAL-INFECTION; NOSOCOMIAL OUTBREAK; SEGMENT; AFRICA; BINDER; DIAGNOSIS; RUSSIA; ASIA AB Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus of the genus Nairovirus and the family Bunyaviridae. It is a negative-strand RNA virus comprised of small (S), medium (M), and large (L) genome segments. The S segment encodes for nucleocapsid protein, the M segment codes for envelope glycoproteins (Gn and Gc), and the L segment codes for the RNA-dependent RNA polymerase. Currently, there are a limited number of methods for rapidly diagnosing CCHFV infections. We developed a real-time, reverse transcription-polymerase chain reaction assay for the rapid detection of CCHFV by using the TaqMan((R))-minor groove binding protein probe technology. The primers and probes were designed to amplify and detect a region in the S segment of CCHFV that is conserved across multiple strains. The limit of detection of the assay was 10 genome copies of RNA. This primer and probe set was specific to 18 strains of CCHFV tested and did not cross-react with either a DNA panel of 78 organisms or a panel of 28 diverse RNA viruses. This will rapidly and specifically detect CCHFV, and it has been used to detect CCHFV infection in samples from humans, animals, and ticks. C1 NIAID, NIH, Bethesda, MD 20892 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. Minist Hlth, Inst Virol, Tashkent, Uzbekistan. USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Paragas, J (reprint author), NIAID, NIH, 33 N Dr,Room 2E19A, Bethesda, MD 20892 USA. EM paragasj@niaid.nih.gov NR 27 TC 22 Z9 23 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2007 VL 77 IS 3 BP 514 EP 520 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 208IE UT WOS:000249312200020 PM 17827370 ER PT J AU Kalayanarooj, S Rimal, HS Andjaparidze, A Vatcharasaevee, V Nisalak, A Jarman, RG Chinnawirotpisan, P Marnmen, MP Holmes, EC Gibbons, RV AF Kalayanarooj, Siripen Rimal, Hem Sagar Andjaparidze, Alex Vatcharasaevee, Varunee Nisalak, Ananda Jarman, Richard G. Chinnawirotpisan, Piyawan Marnmen, Marnmen P. Holmes, Edward C. Gibbons, Robert V. TI Short report: Clinical intervention and molecular characteristics of a dengue hemorrhagic fever outbreak in Timor leste, 2005 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB In response to a January 2005 report of dengue hemorrhagic fever (DHF) in Timor Leste, the World Health Organization sent a team to assist the National Hospital Guido Valadares (NHGV) in Dili with clinical case management and diagnostic support. The hospital reported 67 admissions including 8 deaths (case fatality rate approximately 12%) over the previous weeks with case histories clinically compatible with DHF. During the intervention, an additional 44 suspected dengue patients were admitted to the pediatric ward of NHGV. Among 41 patients with clinical diagnoses of dengue fever or DHF, 38 (93%) were laboratory confirmed. Although cause and effect cannot be definitely attributed, the case fatality rate decreased to 3.6% after the intervention with education about dengue management strategies. C1 Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. Queen Sirikit Natl Inst Child Hlth, Bangkok 10400, Thailand. Natl Hosp Guido Valadares, Dili, E Timor, Indonesia. World Hlth Org, Dili, Timor Leste, Indonesia. Penn State Univ, Dept Biol, University Pk, PA 16802 USA. US Army Med Mat Dev Act, Ft Detrick, MD 21702 USA. RP Gibbons, RV (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM Robert.Gibbons@afrims.org OI Holmes, Edward/0000-0001-9596-3552 NR 11 TC 8 Z9 8 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2007 VL 77 IS 3 BP 534 EP 537 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 208IE UT WOS:000249312200024 PM 17827374 ER PT J AU Mehta, SG Koertner, A Malone, RC AF Mehta, S. G. Koertner, A. Malone, R. C. TI A national survey of bedside teaching in emergency medicine residency programs SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 08-09, 2007 CL Seattle, WA SP Amer Coll Emergency Phys C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2007 VL 50 IS 3 SU S MA 371 BP S116 EP S116 DI 10.1016/j.annemergmed.2007.06.310 PG 1 WC Emergency Medicine SC Emergency Medicine GA 211PL UT WOS:000249535600373 ER PT J AU Mehta, SG McNeill, CR Kolkebeck, T AF Mehta, S. G. McNeill, C. R. Kolkebeck, T. TI An observational study of emergency medicine bedside ultrasound in a far-forward deployed military operational environment SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 08-09, 2007 CL Seattle, WA SP Amer Coll Emergency Phys C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2007 VL 50 IS 3 SU S MA 212 BP S67 EP S67 DI 10.1016/j.annemergmed.2007.06.364 PG 1 WC Emergency Medicine SC Emergency Medicine GA 211PL UT WOS:000249535600212 ER PT J AU Mehta, SG Cox, ED Perkins, JG Wade, CE McLaughlin, DF Spinella, PC Holcomb, JB AF Mehta, S. G. Cox, E. D. Perkins, J. G. Wade, C. E. McLaughlin, D. F. Spinella, P. C. Holcomb, J. B. TI Recombinant activated factor VII (rFVIIa) upon arrival in the emergency department in the severely injured trauma patient SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 08-09, 2007 CL Seattle, WA SP Amer Coll Emergency Phys C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. William Beaumont Army Med Ctr, El Paso, TX 79920 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2007 VL 50 IS 3 SU S BP S1 EP S1 DI 10.1016/j.annemergmed.2007.06.029 PG 1 WC Emergency Medicine SC Emergency Medicine GA 211PL UT WOS:000249535600002 ER PT J AU Morton, MJ Williams, JM Piper, JJ Jones, JA McManus, JG AF Morton, M. J. Williams, J. M. Piper, J. J. Jones, J. A. McManus, J. G., Jr. TI Rapid response team intervention for unstable patients in a community hospital system SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 08-09, 2007 CL Seattle, WA SP Amer Coll Emergency Phys C1 USA, Inst Surg Res, San Antonio, TX USA. Methodist Hlth Care Syst, San Antonio, TX USA. Univ Penn, Sch Med, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2007 VL 50 IS 3 SU S MA 266 BP S84 EP S84 DI 10.1016/j.annemergmed.2007.06.252 PG 1 WC Emergency Medicine SC Emergency Medicine GA 211PL UT WOS:000249535600267 ER PT J AU Morton, MJ McManus, JG Ryan, KL Rickards, CA Cooke, WH Convertino, VA AF Morton, M. J. McManus, J. G., Jr. Ryan, K. L. Rickards, C. A. Cooke, W. H. Convertino, V. A. TI End-tidal C02 correlates with, but may not be an early predictor of, central hypovolemia in humans SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Scientific Assembly of the American-College-of-Emergency-Physicians (ACEP) CY OCT 18-19, 2007 CL Seattle, WA SP Amer Coll Emergency Phys (ACEP) C1 Univ Penn, Sch Med, Philadelphia, PA 19104 USA. USA, Inst Surg Res, San Antonio, TX USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas San Antonio, San Antonio, TX 78285 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2007 VL 50 IS 3 SU S MA 200 BP S63 EP S64 DI 10.1016/j.annemergmed.2007.06.352 PG 2 WC Emergency Medicine SC Emergency Medicine GA 211PL UT WOS:000249535600200 ER PT J AU Morton, MJ Holcomb, JB McManus, JG Kerr, ST Pusateri, AE AF Morton, M. J. Holcomb, J. B. McManus, J. G., Jr. Kerr, S. T. Pusateri, A. E. TI Needle versus tube thoracostomy in a swine model of traumatic tension hemopneumothorax SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 08-09, 2007 CL Seattle, WA SP Amer Coll Emergency Phys C1 Univ Penn, Sch Med, Philadelphia, PA 19104 USA. USA, Inst Surg Res, San Antonio, TX USA. USN, Med Ctr, San Diego, CA 92152 USA. Novo Nordisk AS, Princeton, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2007 VL 50 IS 3 SU S MA 171 BP S54 EP S55 DI 10.1016/j.annemergmed.2007.06.204 PG 2 WC Emergency Medicine SC Emergency Medicine GA 211PL UT WOS:000249535600171 ER PT J AU Sund, CJ McMasters, S Crittenden, SR Harrell, LE Sumner, JJ AF Sund, Christian J. McMasters, Sun Crittenden, Scott R. Harrell, Lee E. Sumner, James J. TI Effect of electron mediators on current generation and fermentation in a microbial fuel cell SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Article DE C. cellulolyticum; cellulose; microbial fuel cell ID CLOSTRIDIUM-CELLULOLYTICUM; ELECTRICITY-GENERATION; CELLULOSE DEGRADATION; OXIDATION; RESAZURIN; GLUCOSE; BIOMASS AB Effects of select electron mediators [9,10-anthraquinone-2,6-disulfonic acid disodium salt (AQDS), safranine O, resazurin, methylene blue, and humic acids] on metabolic end-products and current production from cellulose digestion by Clostridium cellulolyticum in microbial fuel cells (MFCs) were studied using capillary electrophoresis and traditional electrochemical techniques. Addition of the mediator resazurin greatly enhanced current production but did not appear to alter the examined fermentation end-products compared to MFCs with no mediator. Assays for lactate, acetate, and ethanol indicate that the presence of safranine O, methylene blue, and humic acids alters metabolite production in the MFC: safranine O decreased the examined metabolites, methylene blue increased lactate formation, and humic acids increased the examined metabolites. Mediator standard redox potentials (E (0)) reported in the literature do not coincide with redox potentials in MFCs due presumably to the electrolytic complexity of media that supports bacterial survival and growth. Current production in MFCs: (1) can be effected by the mediator redox potential while in the media, which may be significantly shifted from E (0), and (2) depended on the ability of the mediator to access the bacterial electron source, which may be cytoplasmic. In addition, some electron mediators had significant effects on metabolic end-products and therefore the metabolism of the organism itself. C1 USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. US Mil Acad, Dept Phys, West Point, NY 10996 USA. RP Sumner, JJ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM jsumner@arl.army.mil RI sund, christian/G-3424-2013 NR 29 TC 66 Z9 68 U1 4 U2 47 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0175-7598 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD SEP PY 2007 VL 76 IS 3 BP 561 EP 568 DI 10.1007/s00253-007-1038-1 PG 8 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 202HX UT WOS:000248893700009 PM 17562040 ER PT J AU Gurton, KP Felton, M Dahmani, R Ligon, D AF Gurton, Kristan P. Felton, Melvin Dahmani, Rachid Ligon, David TI In situ infrared aerosol spectroscopy for a variety of nerve agent simulants using flow-through photoacoustics SO APPLIED OPTICS LA English DT Article ID ABSORPTION; LASER AB We present newly measured results of an ongoing experimental program established to measure optical cross sections in the mid- and long-wave infrared for a variety of chemically and biologically based aerosols. For this study we consider only chemically derived aerosols, and in particular, a group of chemical compounds often used as simulants for the detection of extremely toxic organophosphorus nerve agents. These materials include: diethyl methylphosphonate (DEMP), dimethyl methylphosphonate (DMMP), diisopropyl methylphosphonate (DIMP), and diethyl phthalate (DEP). As reported in a prior study [Appl. Opt. 44, 4001 (2005)], we combine two optical techniques well suited for aerosol spectroscopy [i.e., flow-through photoacoustics and Fourier transform infrared (FTIR) emission spectroscopy], to measure in situ the absolute extinction and absorption cross sections over a variety of wavelengths spanning the IR spectral region from 3 to 13 mu m. Aerosol size distribution(s), particle number density, and dosimetric measurements are recorded simultaneously in order to present optical cross sections that are aerosol mass normalized, i.e., m(2)/gram. Photoacoustic results, conducted at a series of CO2 laser lines, compare well with measured broadband FTIR spectral extinction. Both FTIR and photoacoustic data also compare well with Mie theory calculations based on measured size distributions and previously published complex indices of refraction. (c) 2007 Optical Society of America. C1 USA, Res Lab, Adelphi, MD 20783 USA. New Mexico State Univ, Lab Phys Sci, Las Cruces, NM 88003 USA. RP Gurton, KP (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM kgurton@arl.army.mil NR 24 TC 8 Z9 8 U1 0 U2 10 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD SEP 1 PY 2007 VL 46 IS 25 BP 6323 EP 6329 DI 10.1364/AO.46.006323 PG 7 WC Optics SC Optics GA 221ZP UT WOS:000250266200017 PM 17805369 ER PT J AU Dines, JS DeBerardino, TM Wells, JL Dodson, CC Shindle, M DiCarlo, EF Warren, RF AF Dines, Joshua S. DeBerardino, Thomas M. Wells, Jason L. Dodson, Christopher C. Shindle, Michael DiCarlo, Edward F. Warren, Russell F. TI Long-term follow-up of surgically treated localized pigmented villonodular synovitis of the knee SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY LA English DT Article DE localized; pigmented villonodular synovitis; knee; arthroscopic treatment ID GIANT-CELL TUMOR; ARTHROSCOPIC TREATMENT; TENDON SHEATH; JOINTS; DIAGNOSIS AB Purpose: The purpose of this study was to review a single institution's large consecutive series of localized pigmented villonodular synovitis (PVNS) of the knee. Methods: Cases for review were identified by a search of our institution's pathology records for definitive diagnoses of monoarticular localized PVNS (LPVNS) of the knee between 1970 and 1996. Patients' presenting symptoms and examination were recorded, as were the preoperative diagnosis and documentation of the PVNS nodule's location in the knee at surgery. Eighty-four patients were diagnosed with localized PVNS of the knee during the study period. Twenty-nine of these cases were incidental findings associated with planned total knee replacement and were excluded from the study. Of the remaining 55 patients constituting the study subgroup, 26 have been reviewed in detail. Results: There were 15 males and I I females, and the mean age at presentation was 36.7 years. Patients presented for evaluation at an average of 15 months after the onset of symptoms. Pain was the most common complaint, reported by 24 of the 26. Locking and giving way were reported by 10 and 5 patients, respectively. On examination, 13 patients had an effusion, I I had joint line tenderness, and 10 had a palpable mass. The most common preoperative diagnosis was a meniscus tear (10 of the 26), followed by PVNS (4), "mass" (4), and anterior cruciate ligament injury (3). At surgery, the nodule of PVNS was found most frequently in the suprapatellar pouch (6 cases), followed by the femoral notch (4), lateral synovium/gutter (4), popliteal fossa (3), lateral compartment (3), and medial compartment (2). Fourteen of the procedures performed were open, and 12 were performed by arthroscopy. Ten of the 26 patients participated in a long-term follow-up via the Lysholm Knee Scoring Scale questionnaire (average, 65.8 months postoperatively; average score, 95.4/100). Of these 10, 7 returned for follow-up clinical examinations (6 excellent results and I good). All 10 patients were operated on arthroscopically, and none required repeat surgery. Conclusions: This review represents the largest series of localized PVNS of the knee to date. Echoing the findings of other PVNS studies, patients presented, on average, in their fourth decade. The common preoperative diagnosis of a meniscal tear is not surprising given the frequent presentation of a painful and, typically, locking knee with joint line tenderness and effusion. Interestingly, what is perhaps the most diagnostic finding on examination, a palpable mass, was present in only I of the 6 patients who had PVNS in the most common location, the suprapatellar pouch. With the ease and utility of modern arthroscopy, however, PVNS is an easily treatable condition that can be diagnosed at the time of surgery. Level of Evidence: Level IV, therapeutic case series. C1 Hosp Special Surg, New York, NY 10021 USA. Keller Army Community Hosp, New York, NY USA. RP Dines, JS (reprint author), Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA. EM dinesj@hss.edu OI DeBerardino, Thomas/0000-0002-7110-8743 NR 33 TC 35 Z9 38 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD SEP PY 2007 VL 23 IS 9 BP 930 EP 937 DI 10.1016/j.arthro.2007.03.012 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 218IV UT WOS:000250010100004 PM 17868831 ER PT J AU Durbin, TD Cocker, DR Sawant, AA Johnson, K Miller, JW Holden, BB Helgeson, NL Jack, JA AF Durbin, Thomas D. Cocker, David R., III Sawant, Aniket A. Johnson, Kent Miller, J. Wayne Holden, Bruce B. Helgeson, Norman L. Jack, Jason A. TI Regulated emissions from biodiesel fuels from on/off-road applications SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE emissions; biodiesel; diesel; vehicles ID DUTY DIESEL VEHICLES; BLENDS AB This research is one of the largest studies of biodiesel in both on-road and off-road uses. The testing was conducted for the military and encompassed a wide range of application types including two medium-duty trucks, two Humvees, a heavy heavy-duty diesel truck, a bus, two stationary backup generators (BUGs), a forklift, and an airport tow vehicle. The full range of fuels tested included a California ultra-low sulfur diesel (ULSD) fuel, different blend ratios of two different yellow-grease biodiesels and one soy-based biodiesel, JP-8, and yellow-grease biodiesel blends with two different NO, reduction additives. The B20-YGA, B20-YGB, and B20-Soy did not show trends relative to ULSD that were consistent over all applications tested. Higher biodiesel blends were tested on only one vehicle, but showed a tendency for higher total hydrocarbons (THC) and carbon monoxide (CO) emissions and lower particulate matter (PM) emissions. The JP-8 showed increases in THC and CO relative to the ULSD. (c) 2007 Published by Elsevier Ltd. C1 Univ Calif Riverside, Dept Environm Chem & Engn, Bourns Coll Engn, CE CERT, Riverside, CA 92521 USA. Naval Facilities Engn Serv Ctr, Port Hueneme, CA USA. USA, Aberdeen Test Ctr, Aberdeen Proving Ground, MD USA. RP Durbin, TD (reprint author), Univ Calif Riverside, Dept Environm Chem & Engn, Bourns Coll Engn, CE CERT, Riverside, CA 92521 USA. EM durbin@cert.ucr.edu RI Cocker, David/F-4442-2010 OI Cocker, David/0000-0002-0586-0769 NR 10 TC 41 Z9 41 U1 1 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 J9 ATMOS ENVIRON JI Atmos. Environ. PD SEP PY 2007 VL 41 IS 27 BP 5647 EP 5658 DI 10.1016/j.atmosenv.2007.02.048 PG 12 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 205WH UT WOS:000249144800008 ER PT J AU McLellan, TM Kamimori, GH Voss, DM Tate, C Smith, SJR AF McLellan, Tom M. Kamimori, Gary H. Voss, David M. Tate, Charmaine Smith, Sarah J. R. TI Caffeine effects on physical and cognitive performance during sustained operations SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE continuous night time operations; restricted sleep; ergogenic and cognitive aids; obstacle course ID LEG MUSCLE PAIN; SLEEP-DEPRIVATION; PROLONGED WAKEFULNESS; MAINTAINS VIGILANCE; PERCEIVED EXERTION; MUSCULAR ENDURANCE; CYCLING EXERCISE; 24 H; MOOD; METABOLISM AB Purpose: This study examined caffeine (CAF) effects on physical performance and vigilance during 4 d and 3 nights of sustained operations in Special Forces personnel. Methods: There were 20 soldiers (28.6 +/- 4.7 yr, 177.6 +/- 7.5 cm, 81.2 +/- 8.0 kg) who were divided equally into placebo (PLAC) and CAF groups. A 4-km run that included three obstacles (OBST) was completed each morning with the performance on Day 2 representing control (CON) after familiarization on Day 1 and an 8-h sleep. From 01:30 to 06:15 of Days 3-5, soldiers performed two 2-h vigilance (VIG) sessions in the field. PLAC or 200 mg of CAF was administered at 21:45 of Days 2-4 and at 01:00, 03:45, and approximately 07:00 on Days 3-5. The run commenced within 30 min of the final dose. Soldiers were provided a 4-h sleep period from 13:30-17:30 during Days 3 and 4. Results: VIG during Days 3-5 was greater for CAF vs. PLAC and not different from CON. Total run time was faster for CAF (29.7 +/- 2.0 min) compared with PLAC (30.7 +/- 2.9 min) on Day 3 due to faster completion of OBST (8.7 +/- 0.7 min vs. 9.2 +/- 1.0 min for CAF and PLAC, respectively). Thereafter, run times decreased for both groups on Days 4 and 5 compared with CON due primarily to an increased pace between OBST. Conclusions: It was concluded that CAF maintained both vigilance and physical performance during sustained operations that require periods of overnight wakefulness and restricted opportunities for daytime sleep. C1 DRDC Toronto, Toronto, ON, Canada. Walter Reed Army Inst Res, Dept Neurobiol & Behav, Div Neuropsychiat, Silver Spring, MD USA. New Zealand DEf Force, Auckland, New Zealand. RP McLellan, TM (reprint author), DRDC Toronto, Individual Readiness Sect, 1133 Sheppard Ave W,PO Box 2000, Toronto, ON M3M 3B9, Canada. EM tom.mclellan@drdc-rddc.gc.ca NR 46 TC 18 Z9 19 U1 1 U2 8 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2007 VL 78 IS 9 BP 871 EP 877 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 206HZ UT WOS:000249175800005 PM 17891897 ER PT J AU Woodard, CL Keenan, SM Gerena, L Welsh, WJ Geyer, JA Waters, NC AF Woodard, Cassandra L. Keenan, Susan M. Gerena, Lucia Welsh, William J. Geyer, Jeanne A. Waters, Norman C. TI Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Pfmrk; CDK7; protein kinase A; malaria; Plasmodium falciparum; kinase inhibitors; cyclin dependent protein kinase; Antimalarials; drug target; parasite ID PLASMODIUM-FALCIPARUM; MOLECULAR-DYNAMICS; DRUG DISCOVERY; DESIGN; TARGETS; IDENTIFICATION; THERAPEUTICS; SYSTEM; ENERGY; MODEL AB We tested Pfmrk against several naphthalene and isoquinoline sulfonamides previously reported as protein kinase A (PKA) inhibitors. Pfmrk is a Cyclin Dependent protein Kinase (CDK) from Plasmodium falciparum, the causative parasite of the most lethal form of malaria. We find that the isoquinoline sulfonamides are potent inhibitors of Pfmrk and that substitution on the 5 position of the isoquinoline ring greatly influences the degree of potency. Molecular modeling studies suggest that the nitrogen atom in the isoquinoline ring plays a key role in ligand-receptor interactions. Structural analysis suggests that even subtle differences in amino acid composition within the active sites are responsible for conferring specificity of these inhibitors for Pfmrk over PKA. (C) 2007 Elsevier Ltd. All rights reserved. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Univ No Colorado, Sch Biol Sci, Greeley, CO 80639 USA. Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA. Univ Med & Dent New Jersey, Inst Informat, Piscataway, NJ 08854 USA. RP Waters, NC (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM norman.waters@us.army.mil NR 35 TC 15 Z9 16 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD SEP 1 PY 2007 VL 17 IS 17 BP 4961 EP 4966 DI 10.1016/j.bmcl.2007.06.032 PG 6 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 205YS UT WOS:000249151700047 PM 17588749 ER PT J AU Grachev, AA Andreas, EL Fairall, CW Guest, PS Persson, POG AF Grachev, Andrey A. Andreas, Edgar L. Fairall, Christopher W. Guest, Peter S. Persson, P. Ola G. TI SHEBA flux-profile relationships in the stable atmospheric boundary layer SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE Arctic Ocean; flux-profile relationships; Monin-Obukhov similarity theory; SHEBA experiment; stable boundary layer ID MONIN-OBUKHOV SIMILARITY; FREQUENCY-RESPONSE CORRECTIONS; SURFACE-LAYER; GRADIENT RELATIONSHIPS; TURBULENCE STRUCTURE; STRONG STABILITY; WIND-SPEED; TEMPERATURE; ICE; CONSTANT AB Measurements of atmospheric turbulence made during the Surface Heat Budget of the Arctic Ocean Experiment (SHEBA) are used to examine the profile stability functions of momentum, phi m, and sensible heat, phi h, in the stably stratified boundary layer over the Arctic pack ice. Turbulent fluxes and mean meteorological data that cover different surface conditions and a wide range of stability conditions were continuously measured and reported hourly at five levels on a 20-m main tower for 11 months. The comprehensive dataset collected during SHEBA allows studying phi m and phi h in detail and includes ample data for the very stable case. New parameterizations for phi m(zeta) and phi h(zeta) in stable conditions are proposed to describe the SHEBA data; these cover the entire range of the stability parameter zeta = z/L from neutral to very stable conditions, where L is the Obukhov length and z is the measurement height. In the limit of very strong stability, phi m follows a zeta(1/3) dependence, whereas phi h initially increases with increasing zeta, reaches a maximum at zeta approximate to 10, and then tends to level off with increasing zeta. The effects of self-correlation, which occur in plots of phi m and phi h versus zeta, are reduced by using an independent bin-averaging method instead of conventional averaging. C1 NOAA, Earth Syst Res Lab, Boulder, CO USA. Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH USA. USN, Postgrad Sch, Monterey, CA USA. RP Grachev, AA (reprint author), NOAA, Earth Syst Res Lab, Boulder, CO USA. EM Andrey.Grachev@noaa.gov OI GRACHEV, ANDREY/0000-0002-7143-0820 NR 62 TC 79 Z9 86 U1 2 U2 17 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 EI 1573-1472 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD SEP PY 2007 VL 124 IS 3 BP 315 EP 333 DI 10.1007/s10546-007-9177-6 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 195MX UT WOS:000248417400001 ER PT J AU Cancio, LC Batchinsky, AI Dubick, MA Park, MS Black, IH Gomez, R Faulkner, JA Pfannenstiel, TJ Wolf, SE AF Cancio, Leopoldo C. Batchinsky, Andriy I. Dubick, Michael A. Park, Myunq S. Black, Ian H. Gomez, Ruben Faulkner, Jeffrey A. Pfannenstiel, Travis J. Wolf, Steven E. TI Inhalation injury: Pathophysiology and clinical care proceedings of a symposium conducted at the trauma institute of San Antonio, San Antonio, TX, USA on 28 march 2006 SO BURNS LA English DT Review DE inhalation injury; mechanical ventilation; acute respiratory distress syndrome ID RESPIRATORY-DISTRESS-SYNDROME; FREQUENCY PERCUSSIVE VENTILATION; OPTICAL COHERENCE TOMOGRAPHY; SMOKE-INHALATION; WOOD SMOKE; GAS INSUFFLATION; PERFUSION RATIOS; BURN MORTALITY; OVINE MODEL; SHEEP C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM lee.cancio@us.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 69 TC 14 Z9 15 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD SEP PY 2007 VL 33 IS 6 BP 681 EP 692 DI 10.1016/j.burns.2006.11.009 PG 12 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 213MC UT WOS:000249670700001 PM 17532146 ER PT J AU Alarcon, CAM McAnally, WH Stockstill, RL AF Alarcon, Cristhian A. Mancilla McAnally, William H. Stockstill, Richard L. TI Hydrodynamic loadings on a floating guard wall at a navigation lock SO CANADIAN JOURNAL OF CIVIL ENGINEERING LA English DT Article DE hydrodynamic forces; lock guard walls; navigation locks; numerical modeling AB New float-in technology is being applied to construction of floating guard walls in navigation projects such as Olmsted lock and dam on the Ohio River. Guard wall fluid-structure interaction design can be decoupled if the effects of the structural response on the fluid load pattern are negligible. The assumption that the hydrodynamic pressures acting on a floating guard wall can be decoupled from the structural response of the wall is tested. The effects of the flow and pressure distribution in the presence of a typical guard wall were modeled and used as boundary conditions for structural analysis of the guard wall. The deformation of the guard wall was then used to recompute the fluid loads. Because the fluid loading did not change significantly, decoupling is considered to be valid. C1 Mississippi State Univ, Dept Civil Engn, Mississippi State, MS 39762 USA. USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP McAnally, WH (reprint author), Mississippi State Univ, Dept Civil Engn, Mississippi State, MS 39762 USA. EM mcanally@engr.msstate.edu NR 11 TC 0 Z9 0 U1 0 U2 2 PU NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS PI OTTAWA PA BUILDING M 55, OTTAWA, ON K1A 0R6, CANADA SN 0315-1468 J9 CAN J CIVIL ENG JI Can. J. Civ. Eng. PD SEP PY 2007 VL 34 IS 9 BP 1069 EP 1074 DI 10.1139/L07-040 PG 6 WC Engineering, Civil SC Engineering GA 231KB UT WOS:000250944500005 ER PT J AU Lanza, E Yu, BB Murphy, G Albert, PS Caan, B Marshall, JR Lance, P Paskett, ED Weissfeld, J Slattery, M Burt, R Iber, F Shike, M Kikendall, JW Brewer, BK Schatzkin, A AF Lanza, Elaine Yu, Binbing Murphy, Gwen Albert, Paul S. Caan, Bette Marshall, James R. Lance, Peter Paskett, Electra D. Weissfeld, Joel Slattery, Marty Burt, Randall Iber, Frank Shike, Moshe Kikendall, James W. Brewer, Brenda K. Schatzkin, Arthur CA Polyp Prevention Trial Study Grp TI The polyp prevention trial-continued follow-up study: No effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomization SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID SURROGATE END-POINTS; COLORECTAL-CANCER; CARCINOMA SEQUENCE; LIFE-STYLE; RISK; TUMORIGENESIS; QUESTIONNAIRE; INTERVENTION; POLYPECTOMY; NUTRITION AB The Polyp Prevention Trial (PPT) was a multicenter randomized clinical trial to evaluate the effects of a high-fiber (18 g/1,000 kcal), high-fruit and -vegetable (3.5 servings/1,000 kcal), and low-fat (20% of total energy) diet on the recurrence of adenomatous polyps in the large bowel over a period of 4 years. Although intervention participants reported a significantly reduced intake of dietary fat, and increased fiber, fruit, and vegetable intakes, their risk of recurrent adenomas was not significantly different from that of the controls. Since the PPT intervention lasted only 4 years, it is possible that participants need to be followed for a longer period of time before treatment differences in adenoma recurrence emerge, particularly if diet affects early events in the neoplastic process. The PPT Continued Follow-up Study (PPT-CFS) was a post-intervention observation of PPT participants for an additional 4 years from the completion of the trial. Of the 1,905 PPT participants, 1,192 consented to participate in the PPT-CFS and confirmed colonoscopy reports were obtained on 801 participants. The mean time between the main trial end point colonoscopy and the first colonoscopy in the PPT-CFS was 3.94 years (intervention group) and 3.87 years (control group). The baseline characteristics of 405 intervention participants and 396 control participants in the PPT-CFS were quite similar. Even though the intervention group participants increased their fat intake and decreased their intakes of fiber, fruits, and vegetables during the PPT-CFS, they did not go back to their prerandomization baseline diet (P < 0.001 from paired t tests) and intake for each of the three dietary goals was still significantly different from that in the controls during the PPT-CFS (P < 0.001 from t tests). As the CFS participants are a subset of the people in the PPT study, the nonparticipants might not be missing completely at random. Therefore, a multiple imputation method was used to adjust for potential selection bias. The relative risk (95% confidence intervals) of recurrent adenoma in the intervention group compared with the control group was 0.98 (0.88-1.09). There were no significant intervention-control group differences in the relative risk for recurrence of an advanced adenoma (1.06; 0.81-1.39) or multiple adenomas (0.92; 0.77-1.10). We also used a multiple imputation method to examine the cumulative recurrence of adenomas through the end of the PPT-CFS: the intervention-control relative risk (95% confidence intervals) for any adenoma recurrence was 1.04 (0.98-1.09). This study failed to show any effect of a low-fat, high-fiber, high-fruit and -vegetable eating pattern on adenoma recurrence even with 8 years of follow-up. C1 NCI, Ctr Canc Res, Lab Can Prevent, Bethesda, MD 20892 USA. Informat Management Serv Inc, Rockville, MD USA. NCI, Canc Prevent Fellowship Program, Div Canc Prevent, Bethesda, MD 20892 USA. Kaiser Fdn Res Inst, Oakland, CA USA. Roswell Pk Canc Inst, Buffalo, NY 14263 USA. Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA. Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. Univ Pittsburgh, Pittsburgh, PA USA. Univ Utah, Salt Lake City, UT USA. US Dept Vet Affairs, Vet Affairs Edward Hines Jr Hosp, Vet Affairs Med Ctr, Hines, IL 60141 USA. Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. Westat Corp, Rockville, MD 20850 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Murphy, G (reprint author), NCI, Ctr Canc Res, Lab Can Prevent, 6116 Execut Blvd,Room 7206, Bethesda, MD 20892 USA. EM murphygw@mail.nih.gov RI Murphy, Gwen/G-7443-2015 NR 40 TC 48 Z9 49 U1 4 U2 11 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD SEP PY 2007 VL 16 IS 9 BP 1745 EP 1752 DI 10.1158/1055-9965.EPI-07-0127 PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 213CN UT WOS:000249643600009 PM 17855692 ER PT J AU Willingham, SB Bergstralh, DT O'Connor, W Morrison, AC Taxman, DJ Duncan, JA Barnoy, S Venkatesan, MI Flavell, RA Deshmukh, M Hoffman, HM Ting, JPY AF Willingham, Stephen B. Bergstralh, Daniel T. O'Connor, William Morrison, Amy C. Taxman, Debra J. Duncan, Joseph A. Barnoy, Shoshana Venkatesan, Malabi Im. Flavell, Richard A. Deshmukh, Mohanish Hoffman, Hal M. Ting, Jenny P. -Y. TI Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/Cryopyrin/NLRP3 and ASC SO CELL HOST & MICROBE LA English DT Article ID COLD AUTOINFLAMMATORY SYNDROME; NF-KAPPA-B; MONOCYTE-DERIVED MACROPHAGES; CASPASE RECRUITMENT DOMAIN; MOBILITY GROUP BOX-1; SHIGELLA-FLEXNERI; INFECTED MACROPHAGES; EPITHELIAL-CELLS; INNATE IMMUNITY; CUTTING EDGE AB Cryopyrin (CIAS1, NLRP3) and ASC are components of the inflammasome, a multiprotein complex required for caspase-1 activation and cytokine IL-1 beta production. CIAS1 mutations underlie autoinflammation characterized by excessive IL-1 beta secretion. Disease-associated cryopyrin also causes a program of necrosis-like cell death in macrophages, the mechanistic details of which are unknown. We find that patient monocytes carrying disease-associated CIAS1 mutations exhibit excessive necrosis-like death by a process dependent on ASC and cathepsin B, resulting in spillage of the proinflammatory mediator HMGB1. Shigella flexneri infection also causes cryopyrin-dependent macrophage necrosis with features similar to the death caused by mutant CIAS1. This necrotic death is independent of caspase-1 and IL-1 beta, and thus independent of the inflammasome. Furthermore, necrosis of primary macrophages requires the presence of Shigella virulence genes. While similar proteins mediate pathogen-induced cell death in plants, this report identifies cryopyrin as an important host regulator of programmed pathogen-induced necrosis in animals, a process we term pyronecrosis. C1 Univ N Carolina, Lineberger Comprehens Canc Ctr, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA. Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA. Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC 27599 USA. Univ N Carolina, Ctr Neurosci, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA. Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06519 USA. Univ Calif San Diego, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA. Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA. RP Ting, JPY (reprint author), Univ N Carolina, Lineberger Comprehens Canc Ctr, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA. EM panyun@.med.unc.edu OI Bergstralh, Dan T/0000-0003-1689-3715 FU NCRR NIH HHS [K12 RR023248, K12RR023248]; NIAID NIH HHS [L30 AI057175, AI057175, AI57175, AI63031, R01 AI063031, R01 AI063031-01A1, U54 AI057157, U54 AI057157-010006, U54 AI057157-07]; NIDCR NIH HHS [DE16326, R01 DE016326, R01 DE016326-01A1] NR 64 TC 181 Z9 186 U1 1 U2 15 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1931-3128 J9 CELL HOST MICROBE JI Cell Host Microbe PD SEP PY 2007 VL 2 IS 3 BP 147 EP 159 DI 10.1016/j.chom.2007.07.009 PG 13 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 221BY UT WOS:000250203600003 PM 18005730 ER PT J AU Helman, DL Brown, AW Jackson, JL Shorr, AF AF Helman, Donald L., Jr. Brown, Alexander W. Jackson, Jeffrey L. Shorr, Andrew F. TI Analyzing the short-term effect of placebo therapy in pulmonary arterial hypertension: Potential implications for the design of future clinical trials SO CHEST LA English DT Article DE metaanalysis; mortality; outcome; placebo; pulmonary arterial hypertension; pulmonary hemodynamics; 6-min walk distance ID CONTINUOUS INTRAVENOUS EPOPROSTENOL; RECEPTOR ANTAGONIST BOSENTAN; INDIVIDUAL PATIENT DATA; DOUBLE-BLIND; PRACTICE GUIDELINES; INHALED ILOPROST; END-POINTS; PROSTACYCLIN ANALOG; WALK TEST; METAANALYSIS AB Background: Placebo is commonly used in short-term randomized trials for pulmonary arterial hypertension (PAH). Currently, outcome data regarding placebo are lacking. We conducted a systematic review and performed a metaanalysis to assess its effect. Methods: Articles were identified via a query of MEDLINE and EMBASE using the following terms: "pulmonary hypertension"; "clinical trial"; "six minute walk"; "pulmonary hemodynamic"; and "survival." A manual bibliography search of selected trials, reviews, and guidelines was performed. The inclusion criteria were as follows: randomized, placebo-controlled with data reported at baseline and at 12 to IS weeks. Two reviewers independently abstracted: 6-min walk distance, pulmonary hemodynamic measures and frequency of death, clinical worsening, and change in New York Heart Association/World Health Organization functional class. The data were pooled using a random-effects model. Results: Thirteen of the 688 articles identified met the inclusion criteria (a total of 868 placebo-treated patients). After 12 to IS weeks, the 6-min walk distance decreased by 8.4 in (95% confidence interval [CI], -14.6 to -2.2) and pulmonary vascular resistance increased by 58.9 dyne . s . cm(-5) (95% CI, 27.6 to 90.1). Placebo-treated patients were 1.81 times more likely to experience a clinical worsening (95% CI, 1.30 to 2.53). Placebo treatment was not associated with a difference in mortality. Conclusions: Patients with PAH who receive placebo are more likely to experience clinical deteriorations. Further debate is needed regarding the design of future clinical trials. Research efforts should focus on evaluating existing medications against one another and comparing novel therapies with currently accepted ones. C1 Dwight D Eisenhower Army Med Ctr, Pulm Dis Clin, Ft Gordon, GA 30905 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. Washington Hosp Ctr, Washington, DC USA. RP Helman, DL (reprint author), Dwight D Eisenhower Army Med Ctr, Pulm Dis Clin, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM donald.helman@gmail.com NR 60 TC 8 Z9 8 U1 1 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD SEP PY 2007 VL 132 IS 3 BP 764 EP 772 DI 10.1378/chest.07-0236 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 214MN UT WOS:000249742100011 PM 17505027 ER PT J AU Schultz, H Weiss, JP AF Schultz, Hendrik Weiss, Jerrold P. TI The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease SO CLINICA CHIMICA ACTA LA English DT Review DE innate immunity; inflammation; host defense; bactericidal/permeability increasing protein; autoantibodies; endotoxin ID LIPOPOLYSACCHARIDE-BINDING-PROTEIN; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; AMINO-TERMINAL FRAGMENT; CYSTIC-FIBROSIS PATIENTS; GRAM-NEGATIVE BACTERIA; SEVERE MENINGOCOCCAL SEPSIS; INDUCED CYTOKINE RELEASE; ESCHERICHIA-COLI; BOWEL-DISEASE; NEISSERIA-MENINGITIDIS AB Gram-negative bacteria (GNB) and their endotoxin present a constant environmental challenge. Endotoxins can potently signal mobilization of host defenses against invading GNB but also potentially induce severe pathophysiology, necessitating controlled initiation and resolution of endotoxin-induced inflammation to maintain host integrity. The bactericidal/permeability-increasing protein (BPI) is a pluripotent protein expressed, in humans, mainly neutrophils. BPI exhibits strong antimicrobial activity against GNB and potent endotoxin-neutralizing activity. BPI mobilized with neutrophils in response to invading GNB can promote intracellular and extracefular bacterial killing, endotoxin neutralization and clearance, and delivery of GNB outer membrane antigens to dendritic cells. Tissue expression by dermal fibroblasts and epithelia could further amplify local levels of BPI and local interaction with GNB and endotoxin, helping to constrain local tissue infection and inflammation and prevent systemic infection and systemic inflammation. This review article focuses on the structural and functional properties of BPI with respect to its contribution to host defense during GNB infections and endotoxin-induced inflammation and the genesis of autoantibodies against BPI that can blunt BPI activity and potentially contribute to chronic inflammatory disease. (c) 2007 Elsevier B.V. All rights reserved. C1 Univ Iowa, Div Infect Dis, Iowa City, IA 52242 USA. USA, Iowa City VAMC, Iowa City, IA 52242 USA. Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA. Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA. Univ Iowa, Inflammat Program, Iowa City, IA 52242 USA. RP Schultz, H (reprint author), Univ Iowa Hosp & Clin, Dept Internal Med, Div Infect Dis, 200 Hawkins Dr SW54 GH, Iowa City, IA 52242 USA. EM Hendrik-Schultz@uiowa.edu FU NIAID NIH HHS [R01 AI059372-01, R01 AI059372, P01 AI044642-050002, P01 AI044642, AI59372]; PHS HHS [P0144642] NR 131 TC 50 Z9 57 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-8981 J9 CLIN CHIM ACTA JI Clin. Chim. Acta PD SEP PY 2007 VL 384 IS 1-2 BP 12 EP 23 DI 10.1016/j.cca.2007.07.005 PG 12 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 211UL UT WOS:000249548700002 PM 17678885 ER PT J AU Weeks, C Moratzc, C Zachariac, A Stracener, C Egan, R Peckham, R Moore, FD Tsokos, GC AF Weeks, Christine Moratzc, Chantal Zachariac, Athina Stracener, Catherine Egan, Ryan Peckham, Russell Moore, Francis D., Jr. Tsokos, George C. TI Decay-accelerating factor attenuates remote ischemia-reperfusion-initiated organ damage SO CLINICAL IMMUNOLOGY LA English DT Article DE complement; inflammation; lung; cell surface molecules; ischemia-reperfusion ID PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; COMPLEMENT REGULATORY PROTEINS; MEMBRANE ATTACK COMPLEX; C1 ESTERASE INHIBITOR; ISCHEMIA/REPERFUSION-INDUCED INJURY; C5A RECEPTOR ANTAGONIST; T-CELL IMMUNITY; TISSUE-INJURY; NATURAL ANTIBODY; INTESTINAL ISCHEMIA/REPERFUSION AB Complement activation contributes to the expression of local and remote organ injury in animal models of ischemia-reperfusion (IR). We demonstrate here that a soluble form of decay-accelerating factor (DAF) protects normal C57Bl/6 and autoimmunity-prone B6.MRL/lpr mice subjected to hindlimb IR from remote intestinal and lung injury without affecting the degree of local skeletal muscle injury. In addition, DAF treatment attenuates remote organ injury in mice subjected to mesenteric IR. Soluble DAF allowed the deposition of complement 3 in local and remote injury sites while it limited the presence of terminal membrane attack complex and did not increase animal susceptibility to sepsis. These data provide evidence that soluble DAF might offer clinical benefit to patients suffering remote intestinal or lung damage in response to muscle or other organ injury. (c) 2007 Elsevier Inc. All rights reserved. C1 Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Rheumatol, Boston, MA 02215 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20910 USA. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA. RP Tsokos, GC (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Rheumatol, 4 Blackfan Circle,HIM-244, Boston, MA 02215 USA. EM gtsokos@bidmc.harvard.edu NR 77 TC 21 Z9 21 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD SEP PY 2007 VL 124 IS 3 BP 311 EP 327 DI 10.1016/j.clim.2007.05.010 PG 17 WC Immunology SC Immunology GA 207ME UT WOS:000249254400010 PM 17631050 ER PT J AU Barry, JD Mallia, AK AF Barry, J. D. Mallia, A. K. TI The misuse and abuse of medications prescribed for attention deficit hyperactivity disorder (ADHD) in the state of Texas SO CLINICAL TOXICOLOGY LA English DT Meeting Abstract C1 Brooke Army Med Ctr, San Antonio, TX USA. San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. Cent Texas Poison Ctr, Temple, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0731-3810 J9 CLIN TOXICOL JI Clin. Toxicol. PD SEP PY 2007 VL 45 IS 6 MA 233 BP 646 EP 646 PG 1 WC Toxicology SC Toxicology GA 214UE UT WOS:000249762900233 ER PT J AU Flanagin, M Grenotton, A Ratcliff, J Shaw, KB Sample, J Abdelguerfi, M AF Flanagin, Maik Grenotton, Aurelien Ratcliff, Jay Shaw, Kevin B. Sample, John Abdelguerfi, Mahdi TI Hydraulic splines - A hybrid approach to modeling river channel geometries SO COMPUTING IN SCIENCE & ENGINEERING LA English DT Article AB The hydraulic spline algorithm generates irregular 2D channel grids from highly accurate cross-sectional survey data at any desired resolution, facilitating its integration with high-density light detection and ranging (lidar) data. C1 USA, Corps Engineers, New Orleans, LA USA. Ecole Cent, Nantes, France. Naval Res Lab, Digital Mapping Charting & Geodesy Anal Program, Washington, DC 20375 USA. Stennis Space Ctr, Naval Res Lab, Mississippi State, MS USA. Univ New Orleans, Dept Comp Sci, New Orleans, LA 70148 USA. RP Flanagin, M (reprint author), USA, Corps Engineers, New Orleans, LA USA. EM maik.c.flanagin@mvn02.usace.army.mil; jay.ratcliff@usace.army.mil; shaw@nrlssc.navy.mil; sample@nrlssc.navy.mil; mahdi@cs.uno.edu NR 22 TC 3 Z9 3 U1 1 U2 4 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1521-9615 J9 COMPUT SCI ENG JI Comput. Sci. Eng. PD SEP-OCT PY 2007 VL 9 IS 5 BP 4 EP 15 DI 10.1109/MCSE.2007.99 PG 12 WC Computer Science, Interdisciplinary Applications SC Computer Science GA 200XV UT WOS:000248797000002 ER PT J AU Pidcoke, HF Wade, CE Wolf, SE AF Pidcoke, Heather F. Wade, Charles E. Wolf, Steven E. TI Insulin and the burned patient SO CRITICAL CARE MEDICINE LA English DT Article DE burns; insulin resistance; muscle wasting; glycemic control; muscle metabolism AB Severe burns lead to insulin resistance, which is associated with hyperglycemia and muscle wasting. Investigators showed relatively recently that control of hyperglycemia with intensive insulin treatment is associated with improved outcomes for those in the intensive care unit, including patients with severe burns. In this article, we review the actions of insulin in terms of glycemic control and muscle metabolism, biochemical and clinical effects of insulin treatment in the severely burned, and the vagaries of glucose control. (Crit Care Med 2007; 35[Suppl.]:S524-S530) C1 [Pidcoke, Heather F.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX USA. USA, Burn Ctr, Inst Surg Res, Washington, DC USA. RP Pidcoke, HF (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX USA. EM steven.wolf@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 FU National Institutes of Health, Bethesda, MD [1 R01 GM063120-04] FX Supported, in part, by grant 1 R01 GM063120-04 from the National Institutes of Health, Bethesda, MD. NR 66 TC 14 Z9 14 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD SEP PY 2007 VL 35 IS 9 SU S BP S524 EP S530 DI 10.1097/01.CCM.0000278065.72486.31 PG 7 WC Critical Care Medicine SC General & Internal Medicine GA V24GW UT WOS:000208399900015 PM 17713403 ER PT J AU Xia, Y Marquart, LN Gunning, ST AF Xia, Yang Marquart, Laura N. Gunning, Sean T. TI What is your diagnosis? SO CUTIS LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. RP Xia, Y (reprint author), Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD SEP PY 2007 VL 80 IS 3 BP 184 EP 184 PG 1 WC Dermatology SC Dermatology GA 214NA UT WOS:000249743800004 PM 17956004 ER PT J AU Gastaidelli, A Balas, B Hardies, J Harrison, SA Belfort, R Brown, K Schenker, S Defronzo, R Cusi, K AF Gastaidelli, A. Balas, B. Hardies, J. Harrison, S. A. Belfort, R. Brown, K. Schenker, S. Defronzo, R. Cusi, K. TI Impact of PPAR-gamma agonists on adipose-tissue insulin resistance in patients with IGT or T2DM and non-alcoholic steatohepatitis (NASH) SO DIABETOLOGIA LA English DT Meeting Abstract CT 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes CY SEP 18-21, 2007 CL Amsterdam, NETHERLANDS SP European Assco Study Diabet C1 CNR, Inst Clin Physiol, Metab Unit, I-56100 Pisa, Italy. Univ Texas, Hlth Sci Ctr, Div Diabet, San Antonio, TX USA. Univ Texas, Hlth Sci Ctr, Res Imaging Ctr, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. RI Hardies, Lou /F-2102-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0012-186X J9 DIABETOLOGIA JI Diabetologia PD SEP PY 2007 VL 50 SU 1 MA 0073 BP S36 EP S36 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 209NP UT WOS:000249395600074 ER PT J AU Todd, CS Abed, AMS Strathdee, SA Scott, PT Botros, BA Safi, N Earhart, KC AF Todd, Catherine S. Abed, Abdullah M. S. Strathdee, Steffanie A. Scott, Paul T. Botros, Boulos A. Safi, Naqibullah Earhart, Kenneth C. TI HIV, hepatitis C, and hepatitis B infections and associated risk behavior in injection drug users, Kabul, Afghanistan SO EMERGING INFECTIOUS DISEASES LA English DT Article ID PREVALENCE; TRANSMISSION; INCARCERATION; COMMUNITY; PAKISTAN; TEHRAN; IRAN AB Limited prevalence data for HIV, hepatitis B surface antigen (HBsAg), and hepatitis C virus (HCV) exist for Afghanistan. We studied a cross-sectional sample of adult injection drug users (IDUs) in Kabul, Afghanistan, from June 2005 through June 2006. Study participants completed interviewer-administered questionnaires and underwent testing for HIV, antibody to HCV, and HBsAg. Overall prevalences of HIV, HCV, and HBsAg were 3.0% (95% confidence interval [Cl] 1.7%-5.1%),36.6% (95% Cl 32.2%-41.0%), and 6.5% (95% Cl 4.2%-8.7%), respectively (N = 464). Among male IDUs (n = 463), risky behavior, including sharing syringes (50.4%), paying women for sex (76.2%), and having sex with men or boys (28.3%), were common. Needle sharing, injecting for >= 3 years, and receiving injections from nonmedical providers were independently associated with increased risk for HCV infection. The high prevalence of risky behavior indicate that Kabul is at risk for an HIV epidemic. Scale-up of harm-reducing interventions is urgently needed. C1 United States Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD 20850 USA. United State Naval, Res Unit 3, Cairo, Egypt. Minist Publ Hlth, Kabul, Afghanistan. Univ Calif San Diego, La Jolla, CA 92093 USA. RP Scott, PT (reprint author), United States Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, 1 Taft Ct,Suite 250, Rockville, MD 20850 USA. EM pscott@hivresearch.org RI Strathdee, Steffanie/B-9042-2009; Valle, Ruben/A-7512-2013 FU FIC NIH HHS [K01 TW007408, K01TW007408] NR 26 TC 54 Z9 55 U1 0 U2 0 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD SEP PY 2007 VL 13 IS 9 BP 1327 EP 1331 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 205XM UT WOS:000249148500008 PM 18252103 ER PT J AU Harris, RR Sullivan, K Cafferata, PH Munn, JR Faucher, KM AF Harris, Richard R. Sullivan, Kthleen Cafferata, Peter H. Munn, John R. Faucher, Kevin M. TI Applications of turbidity monitoring to forest management in California SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE turbidity; suspended sediment; monitoring; forest management; California ID SUSPENDED SEDIMENT; WATER-QUALITY; ROAD EROSION; TRANSPORT; RUNOFF; CATCHMENT; AUSTRALIA; STREAMS; IMPACT; RIVER AB Many California strearns have been adversely affected by sedimentation caused by historic and current land uses. including timber harvesting. The impacts of timber harvesting and lo-ing transportation systems on erosion and sediment delivery can be directly measured, modeled. or inferred from water quality measurements. California regulatory agencies, researchers, and land owners have adopted turbidity monitoring to determine effects of forest management practices on suspended sediment loads and water quality at watershed, project, and site scales. Watershed-scale trends in sediment discharge and responses to current forest practices may be estimated from data collected at automated sampling stations that measure tuirbidity. stream flow, suspended sediment concentrations. and other water quality parameters. Future results from these studies will provide a basis for assessing the effectiveness of modern forest practice regulations in protecting water quality. At the project scale, manual sampling of water column turbidity during high stream flow events within and downstream from active timber harvest plans can identify emerging sediment sources. Remedial actions can then be taken by managers to prevent or mitigate water quality impacts. At the site scale, manual turbidity sampling during storms or high stream flow events at sites located upstream and downstream from new, upgraded, or decommissioned stream crossings has proven to be a valuable way to determine whether measures taken to prevent post-construction erosion and sediment production are effective. Turbidity monitoring at the project and site scales is therefore an important tool for adaptive management. Uncertainty regarding the effects of current forest practices must be resolved through watershed-scale experiments. In the short term, this uncertainty will stimulate increased use of project and site-scale monitoring. C1 Univ Calif Berkeley, Berkeley, CA 94720 USA. Pacific Lumber Co, Scotia, CA 95565 USA. Calif Dept Forestry & Fire Protect, Sacramento, CA 94244 USA. Calif Dept Forestry & Fire Protect, Soil Eros Study Project, Sacramento, CA 94244 USA. Campbell Timberland Management, Ft Bragg, CA 95437 USA. RP Harris, RR (reprint author), Univ Calif Berkeley, Berkeley, CA 94720 USA. EM rrharris@nature.berkeley.edu NR 57 TC 6 Z9 6 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD SEP PY 2007 VL 40 IS 3 BP 531 EP 543 DI 10.1007/s00267-006-0195-9 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA 206SI UT WOS:000249202800015 PM 17562100 ER PT J AU Cheuvront, SN Montain, SJ Goodman, DA Blanchard, L Sawka, MN AF Cheuvront, Samuel N. Montain, Scott J. Goodman, Daniel A. Blanchard, Laurie Sawka, Michael N. TI Evaluation of the limits to accurate sweat loss prediction during prolonged exercise SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE fluid balance; hydration; zone of indifference; water requirements; modeling ID HUMAN-SKIN WETTEDNESS; ENDURANCE EXERCISE; TEMPERATURE; PERFORMANCE; HEAT; EFFICIENCY; RESPONSES; WEIGHT; AIR AB Sweat prediction equations are often used outside their boundaries to estimate fluid requirements and generate guidance. The limitations associated with these generalized predictions have not been characterized. The purposes of this study were to: (1) evaluate the accuracy of a widely used sweat prediction equation (SHAP) when widening it's boundaries to include cooler environments (2 h) and very prolonged exercise (8 h), (2) determine the independent impact of holding skin temperature constant (SHAP(36)), and (3) describe how adjustments for non-sweat losses (NSL) and clothing saturation dynamics affect prediction accuracy. Water balance was measured in 39 volunteers during 15 trials that included intermittent treadmill walking for 2 h (300-600 W, 15-30 degrees C; n = 21) or 8 h (300-420 W. 20-40 degrees C; n = 18). Equation accuracy was assessed by comparing actual and predicted sweating rates (211 observations) using least-squares regression. Mean and 95% confidence intervals for group differences were compared against a zone of indifference ( +/- 0.125 l/h). Sweating rate variance accounted for by SHAP and SHAP(36) was always high (r(2) > 0.70), while the standard error of the estimate was small and uniform around the line of best fit. SNAP errors were > 0.125 l/h during 2 and 8 h of exercise. SHAP36 errors were < 0.125 l/h for 2 h conditions but were higher at 8 h in three of the six warmest trials. Adjustments for NSL and clothing saturation dynamics help explain SHAP errors at 2 and 8 h, respectively. These results provide a basis for future development of accurate algorithms with broader utility. C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Samuel.cheuvront@na.amedd.army.mil NR 38 TC 23 Z9 23 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD SEP PY 2007 VL 101 IS 2 BP 215 EP 224 DI 10.1007/s00421-007-0492-x PG 10 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 207GT UT WOS:000249240300004 PM 17534643 ER PT J AU O'Connell, RJ Peel, SA AF O'Connell, Robert J. Peel, Sheila A. TI Multispot((TM)) HIV-1/HIV-2 rapid test SO EXPERT REVIEW OF MOLECULAR DIAGNOSTICS LA English DT Review DE flow-through; HIV-1; HIV-2; HIV subtype differentiation; Multispot((TM)) HIV-1/HIV-2 rapid test; rapid HIV testing ID HUMAN-IMMUNODEFICIENCY-VIRUS; TYPE-1 INFECTION; GENETIC DIVERSITY; FIELD-EVALUATION; DIAGNOSIS; HIV-1; ASSAYS; DIFFERENTIATION; IMMUNOASSAYS; SPECIFICITY AB The Multispot(TM) HIV-1/HIV-2 Rapid Test is sensitive and specific for the detection and differentiation of HIV-1 and HIV-2. These attributes, along with best-in-class specificity among HIV-1 rapid tests, make its use attractive in a confirmatory capacity, especially in settings where HIV-2 is prevalent. Widespread use as a primary screening test is largely thwarted by moderate complexity and high cost. C1 Walter Reed Army Inst Res, Dept Lab Diagnost & Monitoring, Div Retrovirol, Rockville, MD 20850 USA. RP O'Connell, RJ (reprint author), Walter Reed Army Inst Res, Dept Lab Diagnost & Monitoring, Div Retrovirol, Rockville, MD 20850 USA. EM roconnell@hivresearch.org; speel@hivresearch.org NR 29 TC 7 Z9 7 U1 1 U2 4 PU FUTURE DRUGS LTD PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1473-7159 J9 EXPERT REV MOL DIAGN JI Expert Rev. Mol. Diagn. PD SEP PY 2007 VL 7 IS 5 BP 499 EP 505 DI 10.1586/14737159.7.5.499 PG 7 WC Pathology SC Pathology GA 222TY UT WOS:000250321400006 PM 17892358 ER PT J AU Browne, H James, A Hoover, D Payson, M Segars, J AF Browne, H. James, A. Hoover, D. Payson, M. Segars, J. TI Couples' choices when faced with the 'unexpected' failure of surgical retrieval of sperm. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 NICHD, Reprod Biol & Med Branch, NIH, Bethesda, MD USA. Walter Reed Army Med Ctr, Dept OB GYN, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S389 EP S389 DI 10.1016/j.fertnstert.2007.07.496 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889801125 ER PT J AU Browne, H Stegmann, BJ Larsen, FW James, A Payson, M Segars, J AF Browne, H. Stegmann, B. J. Larsen, F. W. James, A. Payson, M. Segars, J. TI A study of 92 patient cycles using the ganirelix salvage protocol in women at risk of OHSS. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 NICHD, NIH, Reprod Biol & Med Branch, Bethesda, MD USA. Walter Reed Army Med Ctr, ART Program, Washington, DC USA. ART Inst Washington Inc, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S34 EP S35 DI 10.1016/j.fertnstert.2007.07.125 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800090 ER PT J AU Frattarelli, JL Hill, MJ McWilliams, GDE Miller, KA Scott, RT AF Frattarelli, J. L. Hill, M. J. McWilliams, G. D. E. Miller, K. A. Scott, R. T. TI A luteal estradiol stimulation protocol improves embryo number and quality for poor-responders undergoing art. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 Reprod Med Associates New Jersey, Morristown, NJ USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RI Hill, Micah/A-6777-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S289 EP S289 DI 10.1016/j.fertnstert.2007.07.975 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800823 ER PT J AU Frattarelli, JL McWilliams, GDE Hill, MJ Miller, KA Scott, RT AF Frattarelli, J. L. McWilliams, G. D. E. Hill, M. J. Miller, K. A. Scott, R. T. TI Low-dose aspirin use does not improve art outcomes in poor responders. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 Reprod Med Associates New Jersey, Morristown, NJ USA. Tripler Army Med Ctr, Honolulu, HI USA. RI Hill, Micah/A-6777-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S126 EP S127 DI 10.1016/j.fertnstert.2007.07.406 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800338 ER PT J AU Levens, ED Wei, Q Nieman, LK AF Levens, E. D. Wei, Q. Nieman, L. K. TI Indian hedgehog and its associated down-stream targets are altered in response to in vivo CDB-2914 administration. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. USN, Med Ctr, Combined Fed Fellowship Reprod Endocrinol & Infer, NIH,Walter Reed Army Med Ctr, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S196 EP S196 DI 10.1016/j.fertnstert.2007.07.673 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800546 ER PT J AU Levens, ED Whitcomb, BW Kort, JD Materia-Hoover, D Feinberg, EC Larsen, FW AF Levens, E. D. Whitcomb, B. W. Kort, J. D. Materia-Hoover, D. Feinberg, E. C. Larsen, F. W. TI A retrospective comparison of microdose follicular phase and luteal phase gonadotropin releasing hormone agonist (GnRH-a) suppression for in vitro fertilization in patients 30 years old and younger. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 Walter Reed Army Med Ctr, ART Program, Washington, DC 20307 USA. USN, Med Ctr, Combined Fed Fellowship Reprod Endocrinol & Infer, NIH,Walter Reed Army Med Ctr, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. NICHHD, Epidemiol Branch, NIH, Bethesda, MD 20892 USA. ART Inst Washington Inc, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S139 EP S140 DI 10.1016/j.fertnstert.2007.07.447 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800377 ER PT J AU Levens, ED Payson, MD Larsen, FW AF Levens, E. D. Payson, M. D. Larsen, F. W. TI A prospective, randomized comparison trial of ovarian follicular re-aspiration at oocyte retrieval among patients with reduced ovarian response undergoing art. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 Walter Reed Army Med Ctr, ART Program, Washington, DC USA. USN, Med Ctr, Combined Fellowship Reprod Endocrinol & Infertil, NIH,Walter Reed Army Med Ctr, Bethesda, MD 20084 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NICHHD, Reprod Biol & Med Branch, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S126 EP S126 DI 10.1016/j.fertnstert.2007.07.404 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800336 ER PT J AU McCarthy-Keith, D Blocker, W Levens, E Nieman, L Armstrong, A AF McCarthy-Keith, D. Blocker, W. Levens, E. Nieman, L. Armstrong, A. TI Recruitment and retention of subjects for clinical leiomyoma trials. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Natl Naval Med Ctr, Walter Reed Army Med Ctr, NIH, Combined Fed Fellowship Reprod Endocrinol & Infer, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S219 EP S219 DI 10.1016/j.fertnstert.2007.07.747 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800615 ER PT J AU Parker, JD AF Parker, J. D. TI The prevalence of endometrial polyps as diagnosed by saline infusion sonohysterography among different body mass indexes. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 Womack AMC, Dept Reprod Endocrinol & Infertil, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S201 EP S202 DI 10.1016/j.fertnstert.2007.07.689 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800561 ER PT J AU Propst, AM Thoppil, JJ Groll, JM Frattarelli, JL Robinson, RD Retzloff, MG AF Propst, A. M. Thoppil, J. J. Groll, J. M. Frattarelli, J. L. Robinson, R. D. Retzloff, M. G. TI Pre-ovulatory vs. ovulatory intrauterine insemination in controlled ovarian hyperstimulation cycles. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 Wilford Hall USAF Med Ctr, San Antonio, TX USA. Wright Patterson Med Ctr, Dayton, OH USA. Tripler Army Med Ctr, Obstet & Gynecol, Honolulu, HI USA. Keesler Med Ctr, Biloxi, MS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S172 EP S173 DI 10.1016/j.fertnstert.2007.07.597 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800477 ER PT J AU Stegmann, BJ Larsen, FW DeCherney, A Segars, J AF Stegmann, B. J. Larsen, F. W. DeCherney, A. Segars, J. TI Presence of blood in the transfer catheter does not affect implantation or clinical pregnancy rates when using the 'afterload' method of ET. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 Walter Reed Army Med Ctr, ART Program, Washington, DC 20307 USA. NICHD, NIH, Reprod Biol & Med Branch, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S117 EP S117 DI 10.1016/j.fertnstert.2007.07.377 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800310 ER PT J AU Stegmann, BJ Payson, M DeCherney, A Segars, J AF Stegmann, B. J. Payson, M. DeCherney, A. Segars, J. TI The 'afterload' method of embryo transfer corrects for provider-dependent effects at et. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 NICHD, Reprod Biol & Med Branch, NIH, Bethesda, MD USA. Walter Reed Army Med Ctr, ART Program, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S103 EP S104 DI 10.1016/j.fertnstert.2007.07.335 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800272 ER PT J AU Wei, Q Levens, ED Nieman, LK AF Wei, Q. Levens, E. D. Nieman, L. K. TI CDB-2914, a novel selective progesterone receptor modulator, differentially regulates endometrial gene expression in the proliferative phase of the menstrual cycle. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. USN, Med Ctr, Combined Fed Fellowship Reprod Endocrinol & Infer, NIH,Walter Reed Army Med Ctr, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S194 EP S194 DI 10.1016/j.fertnstert.2007.07.667 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800540 ER PT J AU Yauger, BJ Chason, RJ Payson, MD AF Yauger, B. J. Chason, R. J. Payson, M. D. TI Cesarean section scars detrimentally affect embryo transfer. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NICHD, Reprod Biol & Med Branch, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S334 EP S334 DI 10.1016/j.fertnstert.2007.07.1115 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800955 ER PT J AU Yauger, BJ Whitcomb, BW Levens, ED Hennessy, S Larsen, EW AF Yauger, B. J. Whitcomb, B. W. Levens, E. D. Hennessy, S. Larsen, E. W. TI The impact of the duration of estradiol supplementation and peak serum estradiol on frozen blastocyst-embryo transfer outcome. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reproduct Med C1 Walter Reed Army Med Ctr, ART Program, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Natl Naval Med Ctr, NIH, Combined Fed Fellowship Reprod Endocrinol & Infer, Bethesda, MD USA. NICHHD, Epidemiol Branch, Bethesda, MD 20892 USA. NICHHD, NIH, Reprod Biol & Med Branch, Bethesda, MD 20892 USA. Inst Washington Inc, ART, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2007 VL 88 SU 1 BP S149 EP S149 DI 10.1016/j.fertnstert.2007.07.475 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 216PC UT WOS:000249889800405 ER PT J AU Forest, J AF Forest, James TI War is a no-win scenario SO FUTURIST LA English DT Editorial Material C1 US Mil Acad, West Point, PA USA. Combating Terrorism Ctr, West Point, PA USA. RP Forest, J (reprint author), US Mil Acad, West Point, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD FUTURE SOC PI BETHESDA PA 7910 WOODMONT AVE, STE 450, BETHESDA, MD 20814 USA SN 0016-3317 J9 FUTURIST JI Futurist PD SEP-OCT PY 2007 VL 41 IS 5 BP 20 EP 20 PG 1 WC Social Issues SC Social Issues GA 199EY UT WOS:000248680200016 ER PT J AU Cole, DM Peters, JF AF Cole, David M. Peters, John F. TI A physically based approach to granular media mechanics: grain-scale experiments, initial results and implications to numerical modeling SO GRANULAR MATTER LA English DT Article; Proceedings Paper CT 1st Workshop on Granular Materials in Lunar and Martian Exploration CY FEB, 2005 CL Cape Canaveral, FL DE micromechanics; contact mechanics; experiments; friction; geologic materials ID FORCE MICROSCOPY; PARTICLE MODEL; SHEAR BANDS; ICE; MICROSTRUCTURE AB It is generally appreciated that the mechanical behavior of granular media depends fundamentally on the interaction of the constituent particles, and that the validity of numerical models of granular media would be greatly improved with knowledge of the grain-scale mechanics. However, most supporting experimental work has been conducted on highly idealized materials, and a limited amount of information exists on grain-scale force-displacement relationships for naturally occurring materials. To address this shortcoming, we are conducting a program that integrates laboratory experiments on grains of naturally occurring aggregate with the discrete element modeling method, with the goal of relating the grain-scale physical and mechanical properties of granular media to bulk behavior. The paper describes the equipment and methods that have been developed to conduct close-loop controlled, grain-scale experiments under monotonic and cyclic loading conditions, and presents results from an initial set of experiments on unbonded grains. The implications of the grain-scale results to the discrete element model are discussed. Discussions center on the applicability of a physically based approach to the mechanics of granular media in general. In light of future exploration missions and the resulting need to predict the mechanical properties of lunar and planetary regoliths, the paper examines the potential usefulness of our physically based approach to the problem of predicting the behavior of the types of materials found in those environments. C1 USA, Corps Engineers, Cold Reg Res & Engn Lab, Ctr Res Dev & Engn, Hanover, NH 03755 USA. USA, Geotech & Struct Lab, Ctr Res Dev & Engn, Vicksburg, MS USA. RP Cole, DM (reprint author), USA, Corps Engineers, Cold Reg Res & Engn Lab, Ctr Res Dev & Engn, 72 Lyme Rd, Hanover, NH 03755 USA. EM David.M.Cole@erdc.usace.army.mil NR 23 TC 23 Z9 23 U1 2 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1434-7636 J9 GRANUL MATTER JI Granul. Matter PD SEP PY 2007 VL 9 IS 5 BP 309 EP 321 DI 10.1007/s10035-007-0046-2 PG 13 WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied SC Materials Science; Mechanics; Physics GA 204BY UT WOS:000249019100003 ER PT J AU Walsh, SDC Tordesillas, A Peters, JF AF Walsh, Stuart D. C. Tordesillas, Antoinette Peters, John F. TI Development of micromechanical models for granular media - The projection problem SO GRANULAR MATTER LA English DT Article; Proceedings Paper CT 1st Workshop on Granular Materials in Lunar and Martian Exploration CY FEB, 2005 CL Cape Canaveral, FL DE micromechanics; micropolar; thermomechanics; mesoscale ID INDEPENDENT DISSIPATIVE MATERIALS; INDUCED ANISOTROPY; THERMOMECHANICAL FRAMEWORK; CONSTITUTIVE MODELS; PLASTICITY THEORY; STRESS; LOCALIZATION; MECHANICS; STRAIN; SOILS AB Micromechanical analysis has the potential to resolve many of the deficiencies of constitutive equations of granular continua by incorporating information obtained from particle-scale measurements. The outstanding problem in applying micromechanics to granular media is the projection scheme to relate continuum variables to particle-scale variables. Within the confines of a projection scheme that assumes affine motion, contact laws based on binary interactions do not fully capture important instabilities. Specifically, these contact laws do not consider mesoscale mechanics related to particle group behaviour such as force chains commonly seen in granular media. The implications of this are discussed in this paper by comparison of two micromechanical constitutive models to particle data observed in computer simulations using the discrete element method (DEM). The first model, in which relative deformations between isolated particle pairs are projected from continuum strain, fails to deliver the observed behaviour. The second model accounts for the contact mechanics at the mesoscale (i.e. particle group behaviour) and, accordingly, involves a nonaffine projection scheme. In contrast with the first, the second model is shown to display strain softening behaviour related to dilatancy and produce realistic shear bands in finite element simulations of a biaxial test. Importantly, the evolution of microscale variables is correctly replicated. C1 Univ Melbourne, Dept Math & Stat, Melbourne, Vic, Australia. USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Tordesillas, A (reprint author), Univ Melbourne, Dept Math & Stat, Melbourne, Vic, Australia. EM atordesi@ms.unimelb.edu.au RI Walsh, Stuart/F-4818-2011; OI Walsh, Stuart/0000-0001-8155-4870 NR 41 TC 32 Z9 35 U1 0 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1434-7636 J9 GRANUL MATTER JI Granul. Matter PD SEP PY 2007 VL 9 IS 5 BP 337 EP 352 DI 10.1007/s10035-007-0043-5 PG 16 WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied SC Materials Science; Mechanics; Physics GA 204BY UT WOS:000249019100006 ER PT J AU Maisonneuve, P Marshall, BC Lowenfels, AB AF Maisonneuve, P. Marshall, B. C. Lowenfels, A. B. TI Risk of pancreatic cancer in patients with cystic fibrosis SO GUT LA English DT Letter ID ADENOCARCINOMA C1 European Inst Oncol, Div Epidemiol & Biostat, I-20141 Milan, Italy. USA, Cyst Fibrosis Fdn, Bethesda, MD USA. New York Med Coll, Valhalla, NY 10595 USA. RP Maisonneuve, P (reprint author), European Inst Oncol, Div Epidemiol & Biostat, Via Ripamonti 435, I-20141 Milan, Italy. EM Patrick.Maisonneuve@ieo.it OI Maisonneuve, Patrick/0000-0002-5309-4704 NR 10 TC 40 Z9 40 U1 0 U2 0 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0017-5749 J9 GUT JI Gut PD SEP PY 2007 VL 56 IS 9 BP 1327 EP 1328 DI 10.1136/gut.2007.125278 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 199WJ UT WOS:000248725600036 PM 17698876 ER PT J AU Martino, MA Williamson, E Rajaram, L Lancaster, JM Hoffman, MS Maxwell, GL Clarke-Pearson, DL AF Martino, M. A. Williamson, E. Rajaram, L. Lancaster, J. M. Hoffman, M. S. Maxwell, G. L. Clarke-Pearson, D. L. TI Defining practice patterns in Gynecologic Oncology to prevent pulmonary embolism and deep venous thrombosis SO GYNECOLOGIC ONCOLOGY LA English DT Article; Proceedings Paper CT 37th Annual Meeting of the Society-of-Gynecologic-Oncologists CY MAR 22-26, 2006 CL Palm Springs, CA SP Soc Gynecol Oncol DE thromboembolism; prophylaxis; heparin; pneumatic; pulmonary embolism; deep venous thrombosis ID MOLECULAR-WEIGHT HEPARIN; PNEUMATIC CALF COMPRESSION; THROMBOEMBOLISM PROPHYLAXIS; COST-EFFECTIVENESS; RANDOMIZED TRIAL; VEIN-THROMBOSIS; OBESE-PATIENTS; SURGERY; MALIGNANCY; RISK AB Objective. The goal of venous thromboembolism (VTE) prophylaxis is to reduce the morbidity and mortality associated with the development of a deep venous thrombosis (DVT) or pulmonary embolism (PE). Because women with gynecologic cancers are at high risk to develop VTE, we sought to determine the present practice patterns of gynecologic oncologists regarding their use of VTE prophylaxis. Methods. 1073 members of the Society of Gynecologic Oncologists (SGO) were mailed surveys that asked about preferred methods to prevent the development of VTE after gynecologic oncology surgery. Data were collected by online member entry and return mail. Frequency distributions were calculated and nonparametric test used for comparisons. Results. 343/1073 (34%) of SGO members and fellows responded. 142/343 (42%) preferred double prophylaxis consisting of external pneumatic compression (EPC) and an anticoagulant while 41% (n=141) preferred EPC with no additional anticoagulation. Of respondents choosing any anticoagulant, 40% preferred Enoxaparin pre- and/or postoperatively. Ovarian cancer patients were perceived by respondents to have the highest risk of developing a postoperative PE. Conclusions. Most respondents agree that women with gynecologic cancers undergoing major surgery should receive VTE prophylaxis, though there is not agreement as to which method is optimal. While 42% of members preferred double prophylaxis, 41% chose no additional measures other than EPC. Randomized studies in gynecologic oncology should be initiated in the United States to determine the optimal practice pattern. (c) 2007 Elsevier hic. All rights reserved. C1 Lehigh Valley Hosp, Ctr Canc, Div Gynecol Oncol, Penn State Canc Inst, Allentown, PA 18104 USA. H Lee Moffitt Canc Ctr & Res Inst, Div Gynecol Oncol, Tampa, FL 33612 USA. Univ S Florida, Dept Epidemiol & Biostat, Tampa, FL 33620 USA. Walter Reed Army Med Ctr, Gynecol Dis Ctr, Washington, DC 20307 USA. US Mil Canc Inst, Washington, DC USA. Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC USA. RP Martino, MA (reprint author), Lehigh Valley Hosp, Ctr Canc, Div Gynecol Oncol, Penn State Canc Inst, 400 N 17th St,Suite 201, Allentown, PA 18104 USA. EM Martin_A.Martino@lvh.com NR 33 TC 19 Z9 21 U1 1 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 EI 1095-6859 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD SEP PY 2007 VL 106 IS 3 BP 439 EP 445 DI 10.1016/j.ygyno.2007.05.001 PG 7 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 209AS UT WOS:000249361100002 PM 17599396 ER PT J AU Mausbach, BT Patterson, TL Rabinowitz, YG Grant, I Schulz, R AF Mausbach, Brent T. Patterson, Thomas L. Rabinowitz, Yaron G. Grant, Igor Schulz, Richard TI Depression and distress predict time to cardiovascular disease in dementia caregivers SO HEALTH PSYCHOLOGY LA English DT Article DE cardiovascular disease; dementia caregiving; depression; distress ID CORONARY-ARTERY-DISEASE; FIBRIN D-DIMER; ALZHEIMERS-DISEASE; PSYCHOLOGICAL STRESSOR; VULNERABLE CAREGIVERS; BEHAVIOR PROBLEMS; PHYSICAL HEALTH; HEART-DISEASE; OLDER-ADULTS; RISK-FACTOR AB Objective: This study assessed the impact of depressive symptoms and distress from patient problem behaviors on time to developing a diagnosis of cardiovascular disease (CVD) in a sample of 643 dementia family caregivers. Design: A longitudinal, prospective design was used. Over an 18-month period, caregivers free from a CVD diagnosis at baseline were assessed at 6, 12, and 18-month follow-ups for the onset of CVD. Main Outcome Measures: Days to the onset of CVD was the primary outcome. Results: Over the length of the study, 32 participants (5%) reported a diagnosis of CVD. After adjusting for sociodemographic and health factors (e.g., high blood pressure, age, smoking history), greater depressive symptoms (p =.040) and distress from patient problem behaviors (p =.034) were significant predictors of time to CVD diagnosis. Conclusion: This study suggests that increased depressive symptoms and reaction to patient problem behaviors (i.e., distress) may increase caregivers' risk for experiencing negative health outcomes, specifically CVD. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA. Univ Pittsburgh, Univ Ctr Social & Urban Res, Pittsburgh, PA 15260 USA. Univ Calif San Diego, Dept Psychiat, Vet Affairs San Diego Hlth Care Syst, La Jolla, CA 92093 USA. RP Mausbach, BT (reprint author), Univ Calif San Diego, Dept Psychiat 0680, 9500 Gilman Dr, La Jolla, CA 92093 USA. EM bmausbach@ucsd.edu OI Mausbach, Brent/0000-0003-2884-8743 FU NIA NIH HHS [AG13265, AG13255, AG13289, AG13297, AG13305, AG13313, AG15301, AG23989]; NINR NIH HHS [NR13269] NR 52 TC 60 Z9 61 U1 3 U2 10 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0278-6133 J9 HEALTH PSYCHOL JI Health Psychol. PD SEP PY 2007 VL 26 IS 5 BP 539 EP 544 DI 10.1037/0278-6133.26.5.539 PG 6 WC Psychology, Clinical; Psychology SC Psychology GA 209AW UT WOS:000249361500007 PM 17845105 ER PT J AU Beidleman, BA Muza, SR Fulco, CS Rock, PB Cymerman, A AF Beidleman, Beth A. Muza, Stephen R. Fulco, Charles S. Rock, Paul B. Cymerman, Allen TI Validation of a shortened electronic version of the environmental symptoms questionnaire SO HIGH ALTITUDE MEDICINE & BIOLOGY LA English DT Article DE altitude; acute mountain sickness; moderate-altitude residents; paper and pencil questionnaire ID ACUTE-MOUNTAIN-SICKNESS; QUALITY-OF-LIFE; SWISS ALPS; ALTITUDE; ASCENT; SUSCEPTIBILITY; AGREEMENT; SEVERITY; TRIAL AB Beidleman, Beth A., Stephen R. Muza, Charles S. Fulco, Paul B. Rock, and Allen Cymerman. Validation of a shortened electronic version of the environmental Symptoms questionnaire. High Alt. Med. Biol. 8:192-199, 2007.-The purpose of this study was to validate a shortened (11-item) electronic version of the 67-item paper and pencil Environmental Symptoms Questionnaire (ESQ-III) to assess acute mountain sickness (AMS). Thirty-three volunteers (means +/- SE; 28 +/- 1 yr; 74 +/- 2 kg) were given both the paper and pencil and electronic versions of the ESQ (IPAQ 5550, Hewlett Packard, Palo Alto, CA) to complete one after the other at residence altitude (RA) and after 24-h (PP24), 48-h (PP48), and 72-h (PP72) exposure to 4300 m on the summit of Pikes Peak (PP). The AMS-Cerebral (AMS-C) weighted factor score was calculated from responses to the same 11 items for each version of the ESQ. If AMS-C was >= 0.7, then the individual was classified as having AMS. There were no differences in the AMS-C scores between the paper and pencil and electronic versions of the ESQ at RA (0.05 +/- 0.01 vs. 0.05 +/- 0.02), PP24 (0.76 +/- 0.16 vs. 0.74 +/- 0.15), PP48 (0.61 +/- 0.15 vs. 0.53 +/- 0.14), and PP72 (0.34 +/- 0.09 vs. 0.34 +/- 0.09). There were no differences in the incidence of AMS between the paper and pencil and electronic versions of the ESQ at RA (0% vs. 0%), PP24 (33% vs. 36%), PP48 (27% vs. 27%), and PP72 (21% vs. 21%). The relationships between AMS-C calculated from the two versions of the ESQ at RA (r = 0.43; p = 0.01), PP24 (r = 0.92; p = 0.0001), PP48 (r = 0.82; p = 0.0005), and PP72 (r = 0.95; p = 0.0001) were significant. The relationships between the incidence of AMS calculated from the two version of the ESQ at RA (k = 0.90; p = 0.01), PP24 (k = 0.90; p = 0.01), PP48 (k = 0.91; p = 0.01), and PP72 (k = 0.92; p = 0.01) were significant. Our findings suggest that the shortened electronic version can be substituted for the paper and pencil version of the ESQ to assess AMS. C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. Oklahoma State Univ, Ctr Aerosp & Hyperbar Med, Tulsa, OK USA. RP Beidleman, BA (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. EM beth.beidleman@na.amedd.army.mil NR 34 TC 21 Z9 22 U1 1 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1527-0297 J9 HIGH ALT MED BIOL JI High Alt. Med. Biol. PD FAL PY 2007 VL 8 IS 3 BP 192 EP 199 DI 10.1089/ham.2007.1016 PG 8 WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences GA 209XF UT WOS:000249420600003 PM 17824819 ER PT J AU Biddle, TD AF Biddle, Tami Davis TI The war complex: World War II in our time SO HISTORIAN LA English DT Book Review C1 USA, War Coll, Carlisle, PA 17013 USA. RP Biddle, TD (reprint author), USA, War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0018-2370 J9 HISTORIAN JI Historian PD FAL PY 2007 VL 69 IS 3 BP 563 EP 564 DI 10.1111/j.1540-6563.2007.00189_39.x PG 2 WC History SC History GA 205KL UT WOS:000249112300043 ER PT J AU Medrano, JD Gonzalez, V Musa, A Quintana, R Shadaram, M AF Medrano, John Daniel Gonzalez, Virgilio Musa, Ahmed Quintana, Rolando Shadaram, Mehdi TI Architecture of a dual-stage optical label switch using out-of-band wavelength and code optical properties SO IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS LA English DT Article DE all-optical switching; optical code-division multiple-access (OCDMA); wavelength-division multiplexing (WDM) ID NETWORKS AB A method of generating circuits in an optical network is optical multiple-protocol lambda switching (OMP lambda S). For ONP lambda KS, the wavelength of the optical carrier is used as an out-of-band label to route data through the network without requiring periodic conversion to the electrical state. A method of adding a second dimension of optical encoding as an out-of-band label used for routing data through a label-switched network is presented. Combining wavelength and code multiplexing techniques generates an O-3 circuit-switched network with a data capacity of up to 5.7 Tb/s on each point-to-point link in the network. The proposed architecture uses two stages to process and map labels for each bit transmitted through the network. The architecture and simulation results for the dual-stage optical label switch (DSOLS) are presented. C1 USA, Data Serv Div, White Sands Missile Range, NM 88002 USA. Univ Texas, Dept Elect & Comp Engn, El Paso, TX 79968 USA. Al Hussein Bin Talal Univ, Dept Comp Engn, Maan 71111, Jordan. Univ Texas, Dept Elect & Comp Engn, San Antonio, TX 78249 USA. Univ Texas, Dept Management Sci & Stat, San Antonio, TX 78249 USA. RP Medrano, JD (reprint author), USA, Data Serv Div, White Sands Missile Range, NM 88002 USA. EM john.d.medrano@wsmr.army.mil; vgonzalez3@utep.edu; shorman@ahu.edu.jo; Rolando.Quintana@utsa.edu; mehdi.shadaram@utsa.edu NR 16 TC 0 Z9 0 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1077-260X J9 IEEE J SEL TOP QUANT JI IEEE J. Sel. Top. Quantum Electron. PD SEP-OCT PY 2007 VL 13 IS 5 BP 1568 EP 1578 DI 10.1109/JSTQE.2007.905504 PN 2 PG 11 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 223MG UT WOS:000250374000026 ER PT J AU Mabry, FJ James, JR Ferguson, AJ AF Mabry, Frank J. James, John R. Ferguson, Aaron J. TI Unicode steganographic exploits - Maintaining enterprise border security SO IEEE SECURITY & PRIVACY LA English DT Article C1 US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. US Mil Acad, Adam Chair Informat Technol, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. US Mil Acad, US Natl Secur Agcy, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Mabry, FJ (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM frank.mabry@usma.edu; john.james@usma.edu; ajferg06@comcost.net NR 6 TC 2 Z9 2 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD SEP-OCT PY 2007 VL 5 IS 5 BP 32 EP 39 DI 10.1109/MSP.2007.128 PG 8 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 217JT UT WOS:000249944900008 ER PT J AU You, C Guo, JR Kraft, RP Chu, M Goda, B McDonald, JF AF You, Chao Guo, Jong-Ru Kraft, Russell P. Chu, Michael Goda, Bryan McDonald, John F. TI A 12-Gb/s DEMUX implemented with SiGe high-speed FPGA circuits SO IEEE TRANSACTIONS ON VERY LARGE SCALE INTEGRATION (VLSI) SYSTEMS LA English DT Article DE current mode logic (CML); field-programmable gate arrays (FPGAs); programmable logic arrays; silicon germanium ID LOGIC BLOCK AB A 7-12-Gb/s demultiplexer implemented with circuits for a high-speed field-programmable gate array (FPGA) is introduced in this paper. Since the first FPGA was released by Xilinx in 1985, FPGAs have become denser and more powerful. The first FPGA that operates in the microwave range was designed in 2000. Various methods, such as a new basic cell structure and multimode routing, are used to make that design faster and less power consuming. Sequential logic functions are analyzed and tested in this paper with a DEMUX implementation using these high-speed FPGA circuits. A chip measurement has shown that the FPGA can operate at a 12-GHz system clock when configured to perform sequential logic. A DEMUX that operates at 12 Gb/s is used here to demonstrate the potential for high-performance and low-power FPGA features. C1 N Dakota State Univ, Dept Elect & Comp Engn, Fargo, ND 58102 USA. IBM Corp, HSS Serial Interface Elect, Hopewell Jct, NY 12533 USA. Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP You, C (reprint author), N Dakota State Univ, Dept Elect & Comp Engn, Fargo, ND 58102 USA. EM chao.you@ndsu.edu; jongru@us.ibm.com; bryan.goda@usma.edu NR 12 TC 2 Z9 2 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1063-8210 J9 IEEE T VLSI SYST JI IEEE Trans. Very Large Scale Integr. (VLSI) Syst. PD SEP PY 2007 VL 15 IS 9 BP 1051 EP 1054 DI 10.1109/TVLSI.2007.902208 PG 4 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 204JA UT WOS:000249038600007 ER PT J AU Cheng, S Valenti, MC Torrieri, D AF Cheng, Shi Valenti, Matthew C. Torrieri, Don TI Robust iterative noncoherent reception of coded FSK over block fading channels SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE EM (expectation maximization) algorithm; ML (maximum likelihood) estimation; NFSK (noncoherent frequency shift keying); turbo code AB An iterative noncoherent receiver is developed for bit-interleaved coded orthogonal multiple frequency-shift keying (FSK) over block fading channels. The receiver uses the Expectation Maximization (EM) algorithm to jointly estimate the received amplitude and noise spectral density of each block. The received symbols and their corresponding channel estimates are passed through a soft-output demapper, deinterleaved, and decoded. Soft-outputs from the decoder are passed back to the channel estimator and demapper to refine estimates of the channel and bit likelihoods, respectively. Several techniques for reducing the estimator's complexity are discussed, and the performance is assessed through simulation. C1 W Virginia Univ, CSEE, Lane Dept, Morgantown, WV 26506 USA. Army Res Lab, Adelphi, MD 20783 USA. RP Cheng, S (reprint author), W Virginia Univ, CSEE, Lane Dept, Morgantown, WV 26506 USA. EM shic@csee.wvu.edu; mvalenti@csee.wvu.edu; dtorr@arl.anny.mil OI Valenti, Matthew/0000-0001-6089-0509 NR 14 TC 7 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD SEP PY 2007 VL 6 IS 9 BP 3142 EP 3147 DI 10.1109/TWC.2007.06020004 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 208GY UT WOS:000249309000002 ER PT J AU Chang, Y Hua, YB Sadler, BM AF Chang, Yu Hua, Yingbo Sadler, Brian M. TI A new design of differential space-time block code allowing symbol-wise decoding SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE coding-gain; differential space-time code; symbol-wise decoding AB For four (or more) transmitters, a new design of differential space-time block code allowing symbol-wise decoding is presented in this letter. The new design not only has the minimum (symbol-wise) decoding complexity as that by Yuen, Guan and Tjhung (YGT) but also yields a lower error rate. While the YGT code uses a specially designed symbol constellation, the new code uses a conventional QAM with a rotation. At a high data rate such as 3bps/Hz, the new design with symbol-wise decoding complexity can even yield a lower error rate than the code by Zhu and Jafarkhani that has the pair-wise decoding complexity. C1 Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. Army Res Lab, Adelphi, MD 20783 USA. RP Chang, Y (reprint author), Rambus Inc, 4440 El Coamino Real, Los Altos, NM 94022 USA. EM yu.ychang@gmail.com; yhua@ee.ucr.edu; bsadler@arl.anny.mil NR 10 TC 3 Z9 3 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1276 EI 1558-2248 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD SEP PY 2007 VL 6 IS 9 BP 3197 EP 3201 DI 10.1109/TWC.2007.06030041 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 208GY UT WOS:000249309000012 ER PT J AU Bozue, J Moody, KL Cote, CK StileS, BG Friedlander, AM Welkos, SL Hale, ML AF Bozue, Joel Moody, Krishna L. Cote, Christopher K. StileS, Bradley G. Friedlander, Arthur M. Welkos, Susan L. Hale, Martha L. TI Bacillus anthracis spores of the bcLA mutant exhibit increased adherence to epithelial cells, fibroblasts, and endothelial cells but not to macrophages SO INFECTION AND IMMUNITY LA English DT Article ID IMMUNODOMINANT PROTEIN; EXOSPORIUM; CEREUS; IDENTIFICATION; PATHOGENESIS; GERMINATION; ANTIBODIES; COAT; MORPHOGENESIS; RESISTANT AB Bacillus anthracis is the causative agent of anthrax, and the spore form of the bacterium represents the infectious particle introduced into a host. The spore is surrounded by an exosporium, a loose-fitting membrane composed of proteins and carbohydrates from which hair-like projections extend. These projections are composed mainly of BcIA (Bacillus-collagen-like protein of B. anthracis). To date, exact roles of the exosporium structure and BcIA protein remain undetermined. We examined differences in spore binding of wild-type Ames and a bcL4 mutant of B. anthracis to bronchial epithelial cells as well as to the following other epithelial cells: A549, CHO, and Caco-2 cells; the IMR-90 fibroblast line; and human umbilical vein vascular endothelium cells. The binding of wild-type Ames spores to bronchial epithelial cells appeared to be a dose-dependent, receptor-ligand-mediated event. There were similar findings for the bcl,4 mutant, with an additional nonspecific binding component likely leading to significantly more adherence to all nonprofessional phagocytic cell types. In contrast, we detected no difference in adherence and uptake of spores by macrophages for either the wild-type Ames or the bcL4 mutant strain. These results suggest that one potential role of the BcIA fibers may be to inhibit nonspecific interactions between B. anthracis spores with nonprofessional phagocytic cells and thus direct the spores towards uptake by macrophages during initiation of infection in mammals. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Bozue, J (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St,Ft Detrick, Ft Detrick, MD 21702 USA. EM joel.a.bozue@us.army.mil NR 44 TC 55 Z9 55 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 2007 VL 75 IS 9 BP 4498 EP 4505 DI 10.1128/IAI.00434-07 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 205RG UT WOS:000249131700036 PM 17606596 ER PT J AU Leath, CA Numnum, TM Straughn, JM Rocconi, RP Huh, WK Kilgore, LC Partridge, EE AF Leath, C. A., III Numnum, T. M. Straughn, J. M., Jr. Rocconi, R. P. Huh, W. K. Kilgore, L. C. Partridge, E. E. TI Outcomes for patients with fallopian tube carcinoma managed with adjuvant chemotherapy following primary surgery: a retrospective university experience SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE chemotherapy; fallopian tube carcinoma; optimal cytoreduction; paclitaxel ID PHASE-II TRIAL; OVARIAN-CANCER; EPITHELIAL OVARIAN; COMBINATION CHEMOTHERAPY; STAGE-III; PACLITAXEL; CISPLATIN; CARBOPLATIN; CYCLOPHOSPHAMIDE; PERITONEUM AB The aim is to evaluate disease-free (DFS) and overall survival (OS) of patients with fallopian tube carcinoma (FTCA) treated with adjuvant chemotherapy. An Institutional Review Board approved retrospective review identified 38 patients with FTCA that received adjuvant chemotherapy following primary surgery from 1975 to 2001. Median age was 56 (range 36-78) and 95% of patients were white. Twenty patients (53%) had FIGO stage III/IV FTCA. Seventeen patients underwent second-look laparotomy, 8 (47%) patients were found to have disease. Adjuvant chemotherapeutic regimens consisted of melphalan in 11 patients, platinum-based chemotherapy without paclitaxel in 17 patients, and the combination of paclitaxel and platinum in 10 patients. Although DFS was similar for the three chemotherapy cohorts (P= 0.19), patients receiving paclitaxel had superior OS compared to patients receiving either melphalan (P = 0.02) or platinum without paclitaxel (P= 0.04). Of the twenty patients with stage III/IV disease, 55% of patients had optimal cytoreduction performed at their initial surgery. Both median DFS, 68 versus 50 months (P = 0.14) and OS, 73 versus 50 months (P = 0.12) were greater in patients with optimal cytoreduction. When compared to historical chemotherapeutic regimens, the combination of paclitaxel and platinum has superior efficacy for the management of patients with FTCA. Although not statistically significant in our study, optimal cytoreduction likely improves both DFS and OS and should be the goal of all patients surgically managed for FTCA. C1 Univ Alabama, Dept Obstet & Gynecol, Div Gynecol Oncol, Birmingham, AL 35294 USA. RP Leath, CA (reprint author), Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM charles.leath@amedd.army.mil OI Leath III, Charles/0000-0002-4034-6845 NR 23 TC 4 Z9 5 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1048-891X J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD SEP-OCT PY 2007 VL 17 IS 5 BP 998 EP 1002 DI 10.1111/j.1525-1438.2007.00903.x PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 210WY UT WOS:000249487500007 PM 17367322 ER PT J AU Fourcroy, JL AF Fourcroy, J. L. TI Regulatory issues in female sexual dysfunction SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH LA English DT Article ID HEALTHY POSTMENOPAUSAL WOMEN; ESTROGEN PLUS PROGESTIN; CLINICAL-TRIALS; DRUG SAFETY; RECOMMENDATIONS; TESTOSTERONE; DEFINITIONS; PREVALENCE; VALIDATION; BEHAVIORS AB Editor's Note: Female sexual dysfunction (FSD) remains an enigmatic area to some, a controversial area to others and the subject of continued, intense debate in the literature. Questions remain regarding the legitimacy of FSD as a bona fide disease; the definition of FSD; the methods of diagnosis; and, the treatment of FSD. In this timely perspective, jean Fourcroy, Consultant in Urology, Endocrinology and Regulatory Issues, discusses the controversies that continue to plague FSD. C1 Walter Reed Army Med Ctr, U SU HS, Bethesda, MD 20817 USA. RP Fourcroy, JL (reprint author), Walter Reed Army Med Ctr, U SU HS, Bethesda, MD 20817 USA. EM sjlfbehr@aol.com NR 32 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0955-9930 J9 INT J IMPOT RES JI Int. J. Impot. Res. PD SEP-OCT PY 2007 VL 19 IS 5 BP 526 EP 529 DI 10.1038/sj.ijir.3901595 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 211AC UT WOS:000249495700018 PM 17786156 ER PT J AU Eyzaguirre, LM Erasilova, IB Nadai, Y Saad, MD Kovtunenko, NG Gomatos, PJ Zeman, VV Botros, BA Sanchez, JL Birx, DL Earhart, KC Carr, JK AF Eyzaguirre, Lindsay M. Erasilova, Isidora B. Nadai, Yuka Saad, Magdi D. Kovtunenko, Natalya G. Gomatos, Peter J. Zeman, Victoria V. Botros, Botdos A. Sanchez, Jose L. Birx, Deborah L. Earhart, Kenneth C. Carr, Jean K. TI Genetic characterization of HIM strains circulating in Kazakhstan SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE former Soviet Union; genetic diversity; HIV-1 molecular epidemiology; injecting drug users ID INJECTING DRUG-USERS; TYPE-1 SUBTYPE-A; DIVERSITY; EPIDEMIC; OUTBREAK; GENOMES; HIV-1 AB To determine the HIV-1 genetic diversity in Kazakhstan, 85 blood samples from HIV-seropositive donors were collected between 2001 and 2003. The study population consisted of 91.8% injecting drug users (IDUs); the remainder was infected sexually or iatrogenically A genomic region that included part of the polymerase gene was sequenced for all 85 samples, and from these, 6 samples were randomly selected for nearly full genome sequencing. Subtype A was the most common genetic form (94.1%), followed by CRF02_AG (4.7%) and subtype C (1.2%). All subtype A sequences clustered closely with samples from countries of the former Soviet Union (FSU). From these sequences, 47 (58.8%) presented the secondary protease inhibitor mutation V77I that has been linked to a genetic lineage in the FSU epidemic. In addition, most had the other 2 mutations that characterize the "V77I haplotype." All 6 nearly full-length sequences were subtype A and clustered with other FSU strains. The CRF02_AG strains from this population clustered with strains from Uzbekistan, reflecting the spread of the CRF02_AG epidemic in Central Asia. The HIV epidemic in Kazakhstan is predominantly in IDUs and is indigenous to the geographic region, and most of the strains are genetically similar to those circulating in the FSU and other parts of Central Asia. C1 Univ Maryland, Inst Human Virol, Dept Epidemiol, Baltimore, MD 21201 USA. Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. Henry M Jackson Fdn Advancement Mil Med, Rockville, MD USA. Natl AIDS Prevent Ctr, Alma Ata, Kazakhstan. USN, Med Res Unit 3, Cairo, Egypt. RP Carr, JK (reprint author), Univ Maryland, Inst Human Virol, Dept Epidemiol, 725 W Lombard St, Baltimore, MD 21201 USA. EM carrj@umbi.umd.edu RI Saad, Magdi/H-5561-2013 OI Saad, Magdi/0000-0003-2111-8115 NR 18 TC 14 Z9 18 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD SEP 1 PY 2007 VL 46 IS 1 BP 19 EP 23 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 206RZ UT WOS:000249201900003 PM 17514018 ER PT J AU Thongcharoen, P Suriyanon, V Paris, RM Khamboonruang, C de Souza, MS Ratto-Kim, S Karnasuta, C Polonis, VR Baglyos, L El Habib, R Gurunathan, S Barnett, S Brown, AE Birx, DL McNeil, JG Kim, JH AF Thongcharoen, Prasert Suriyanon, Vinai Paris, Robert M. Khamboonruang, Chirasak de Souza, Mark S. Ratto-Kim, Silvia Karnasuta, Chitraporn Polonis, Victoria R. Baglyos, Lynn El Habib, Raphaelle Gurunathan, Sanjay Barnett, Susan Brown, Arthur E. Birx, Deborah L. McNeil, John G. Kim, Jerome H. CA Thai AIDS Vaccine Evaluation Grp TI A phase 112 comparative vaccine trial of the safety and immunogenicity of a CRF01_AE (Subtype E) candidate vaccine - ALVAC-HIV (vCP1521) prime with oligomeric gp160 (92TH023/LAI-DID) or bivolent gp120 (CM235/SF2) boost SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article; Proceedings Paper CT 14th International AIDS Conference CY JUL 07-12, 2002 CL BARCELONA, SPAIN SP Univ N Carolina, Gen Clin Res Ctr, UNC Ctr AIDS Res, Natl Inst Hlth, Swiss Natl AIDS Res Program, Bristol-Myers Squibb Co, Boehringer Ingelheim, GlaxoWellcome Res & Dev, HIV Antiviral Res DE HIV-1; phase 1/2; subtype E; CRF01_AE; Thailand; vaccine ID T-LYMPHOCYTE RESPONSES; CANARYPOX VACCINE; TYPE-1 VACCINE; THAI ADULTS; IMMUNODEFICIENCY; COMBINATION; VOLUNTEERS; RGP120; NEUTRALIZATION; IMMUNIZATION AB Background: The development of an effective HIV-1 vaccine is critical to control the pandemic. A prime-boost HIV-1 vaccine trial assessing safety and immunogenicity was conducted in Thailand as part of an evaluation of candidate regimens for a phase 3 efficacy trial. Methods: ALVAC-HIV (vCP1521), expressing circulating recombinant form 01_AE (CRF01_AE) gp120/subtype B LAI and subtype B Gag/Protease boosted with recombinant envelope oligomeric CRF01_AE gp160(ogp160) or bivalent CRF01_AE/subtype B gp120 CM235/SF2, was evaluated in a phase I/II trial of 130 HIV-negative Thai adults. Results: One hundred forty volunteers were enrolled, and 130 completed all safety and immunogenicity visits. Reactogenicity was common but generally mild, and there was no significant difference in the adverse event rate between vaccine and placebo recipients (P = 0.26). There were 7 serious adverse events during the follow-up period, none of which were vaccine related. Cumulative HIV-specific, CD8-mediated, cytotoxic T-lymphocyte responses were observed in 11 (25%) of 44 subjects who received ALVAC boosted by bivalent gp120 and in 5 (11%) of 45 subjects who received ALVAC boosted by ogp160, but these differences were not statistically significant compared with those in placebo recipients (P = 0.62 and P = 0.37, respectively). HIV-specific lymphoproliferative responses were detected in 84% of subunit-boosted vaccine recipients and in 10% of placebo recipients. Neutralizing antibody responses to CRF01_AE and subtype B laboratory strains were seen in 95% of ogp160-boosted and 100% of gp120 B/E-boosted vaccinees, respectively. Conclusions: These 2 different prime-boost regimens seem to be safe and displayed cell-mediated immune responses consistent with those in other trials of canarypox vectors. C1 Mahidol Univ, Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok 10700, Thailand. Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. Armed Forces Res Inst Med Sci, US Army Med Component, Dept Retrovirol, Bangkok 10400, Thailand. Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. Sanofi Pasteur, Swiftwater, PA USA. Sanofi Pasteur, Lyon, France. Novartis Vaccines & Diagnost, Emeryville, CA USA. US Army Med Mat Dev Activ, Ft Detrick, MD USA. US Ctr Dis Control & Prevent, Global Programme AIDS, Atlanta, GA USA. PATH Malaria Vaccine Initiat, Bethesda, MD USA. RP Thongcharoen, P (reprint author), Mahidol Univ, Siriraj Hosp, Fac Med, Dept Microbiol, 2 Pran Nok Rd Bangkok Noi, Bangkok 10700, Thailand. EM siptc@mahidol.ac.th NR 21 TC 58 Z9 61 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD SEP 1 PY 2007 VL 46 IS 1 BP 48 EP 55 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 206RZ UT WOS:000249201900007 PM 17909315 ER PT J AU Duraisamy, K McCroskey, WJ Baeder, JD AF Duraisamy, Karthikeyan McCroskey, William J. Baeder, James D. TI Analysis of wind tunnel wall interference effects on subsonic unsteady airfoil flows SO JOURNAL OF AIRCRAFT LA English DT Article; Proceedings Paper CT AIAA 24th Applied Aerodynamics Conference CY JUN 05-08, 2006 CL San Francisco, CA SP Amer Inst Aeronaut & Astronaut ID DIFFERENCE; SCHEMES AB In this work, the effect of wall interference on steady and oscillating airfoils in a subsonic wind tunnel is studied. A variety of approaches including linear theory, compressible inviscid and viscous computations, and experimental data are considered. Integral transform solutions of the linearized potential equations show an augmentation of the lift magnitude for steady flows when the wall is close to the airfoil surface. For oscillating airfoils, lift augmentation is accompanied by a significant change in the phase of the lift response. Idealized compressible Euler calculations are seen to corroborate the linear theory under conditions that are sufficiently away from acoustic resonance. Further, the theory compares well with compressible Reynolds-averaged Navier-Stokes calculations and experimental measurements over a wide range of attached flows at subsonic Mach numbers. The present methodology can thus be used to predict wall interference effects and also to help extrapolate linear and nonlinear (dynamic stall) wind tunnel data to free-air conditions. C1 Univ Maryland, College Pk, MD 20742 USA. NASA, Ames Res Ctr, USA, Aerofightdynam Directorate, Moffett Field, CA 94035 USA. RP Duraisamy, K (reprint author), Univ Glasgow, Dept Engn, Glasgow G12 8QQ, Lanark, Scotland. RI Duraisamy, Karthikeyan/F-2174-2010 NR 14 TC 6 Z9 6 U1 0 U2 7 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD SEP-OCT PY 2007 VL 44 IS 5 BP 1683 EP 1690 DI 10.2514/1.28143 PG 8 WC Engineering, Aerospace SC Engineering GA 223IK UT WOS:000250363300026 ER PT J AU Lindsey, CY Richardson, JD Brown, JE Hale, ML AF Lindsey, Changhong Y. Richardson, Jenny D. Brown, J. Edward Hale, Martha L. TI Intralaboratory validation of cell-free translation assay for detecting ricin toxin biological activity SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article ID ELISA; MACROMOLECULES; QUANTIFICATION AB A cell-free translation (CFT) assay for determining ricin biological activity was validated. The statistical data from the validation study showed a high level of precision within and between runs of the assay. The assay was specific for determining ricin biological activity in food-based matrixes and discriminated ricin from other ribosome-inactivating proteins. The mean bias (relative error) between measured ricin concentrations of 3 validation samples and their nominal concentrations was 1.1, 6.6, and 20.3%, while the coefficient of variation (CV) was 14.1, 7.7, and 13.5%, respectively, demonstrating good precision, accuracy, and linearity. The CVs of ricin concentrations in 2 ricin-containing samples calculated from a dilution series were <5 and <12%, respectively, demonstrating very good parallelism. The analyte stability of ricin-containing samples stored for 1 month either at 4 or -20 degrees C, the stability of ricin stock solutions, and the results of assays executed by different analysts and using different luminometers were evaluated. The statistical validation data confirmed that the 4-parameter logistic equation, y = (a-d)/[1 + (x/c)(b)] + d, provided an accurate representation of a sigmoidal relationship between the measured response and the observed ricin concentration for the CFT assay. C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Lindsey, CY (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM changhong.lindsey@amedd.army.mil NR 29 TC 8 Z9 8 U1 0 U2 1 PU AOAC INT PI GAITHERSBURG PA 481 N FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 USA SN 1060-3271 EI 1944-7922 J9 J AOAC INT JI J. AOAC Int. PD SEP-OCT PY 2007 VL 90 IS 5 BP 1316 EP 1325 PG 10 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA 214QI UT WOS:000249752800013 PM 17955975 ER PT J AU Ryerson, CC Ramsay, AC AF Ryerson, Charles C. Ramsay, Allan C. TI Quantitative ice accretion information from the automated surface observing system SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article ID FREEZING-RAIN; UNITED-STATES; DRIZZLE; ASOS AB Freezing precipitation is a persistent winter weather problem that costs the United States millions of dollars annually. Costs and infrastructure disruption may be greatly reduced by ice-storm warnings issued by the National Weather Service (NWS), and by the development of climatologies that allow improved design of infrastructure elements. However, neither the NWS nor developers of climatologies have had direct measurements of ice-storm accumulations as a basis for issuing warnings and developing storm design standards. This paper describes the development of an aviation routine/special weather report (METAR/SPECI) remark that will report quantitative ice thickness at over 650 locations during ice storms using new algorithms developed for the Automated Surface Observing System (ASOS). Characteristics of the ASOS icing sensor, a field program to develop the algorithms, tests of accuracy, application of the algorithms, and sources of error are described, as is the implementation of an ice-thickness METAR/SPECI remark. The algorithms will potentially allow freezing precipitation events to be tracked with regard to ice accumulation in near-real time as they progress across the United States. C1 US Army Corps Engn, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, D-03755 Hannover, Germany. RP Ryerson, CC (reprint author), US Army Corps Engn, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, 72, Lyme Rd, D-03755 Hannover, Germany. EM charles.c.ryerson@erdc.usace.army.mil NR 45 TC 9 Z9 9 U1 0 U2 1 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD SEP PY 2007 VL 46 IS 9 BP 1423 EP 1437 DI 10.1175/JAM2535.1 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 218HF UT WOS:000250005900009 ER PT J AU Batchinsky, AI Weiss, WB Jordan, BS Dick, EJ Cancelada, DA Cancio, LC AF Batchinsky, Andriy I. Weiss, William B. Jordan, Bryan S. Dick, Edward J., Jr. Cancelada, David A. Cancio, Leopoldo C. TI Ventilation-perfusion relationships following experimental pulmonary contusion SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ventilation-perfusion mismatch; shunt; multiple inert gas elimination technique; computed tomography ID RESPIRATORY-DISTRESS-SYNDROME; SMOKE-INHALATION INJURY; BLUNT CHEST TRAUMA; END-EXPIRATORY PRESSURE; ACUTE LUNG INJURY; GAS-EXCHANGE; CONTINUOUS DISTRIBUTIONS; COMPUTED-TOMOGRAPHY; OVINE MODEL; DEAD-SPACE AB Ventilation-perfusion changes after right-sided pulmonary contusion (PC) in swine were investigated by means of the multiple inert gas elimination technique (MIGET). Anesthetized swine (injury, n = 8; control, n = 6) sustained a right-chest PC by a captive-bolt apparatus. This was followed by a 12-ml/kg hemorrhage, resuscitation, and reinfusion of shed blood. MIGET and thoracic computed tomography (CT) were performed before and 6 h after injury. Three-dimensional CT scan reconstruction enabled determination of the combined fractional volume of poorly aerated and non-aerated lung tissue (VOL), and the mean gray-scale density (MGSD). Six hours after PC in injured animals, Pa-O2 decreased from 234.9 +/- 5.1 to 113.9 +/- 13.0 mmHg. Shunt (Q(S)) increased (2.7 +/- 0.4 to 12.3 +/- 2.2%) at the expense of blood flow to normal ventilation/perfusion compartments (97.1 +/- 0.4 to 87.4 +/- 2.2%). Dead space ventilation (V-D/V-T) increased (58.7 +/- 1.7% to 67.2 +/- 1.2%). MGSD increased (-696.7 +/- 6.1 to -565.0 +/- 24.3 Hounsfield units), as did VOL (4.3 +/- 0.5 to 33.5 +/- 3.2%). Multivariate linear regression of MGSD, VOL, V-D/V-T, and Q(S) vs. Pa-O2 retained VOL and Q(S) (r(2) = .835) as independent covariates of Pa-O2. An increase in Q(S) characterizes lung failure 6 h after pulmonary contusion; Q(S) and VOL correlate independently with Pa-O2. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Blanchfield Army Community Hosp, Dept Surg, Ft Campbell, KY USA. SW Fdn Biomed Res, San Antonio, TX 78284 USA. William Beaumont Army Med Ctr, Dept Surg, El Paso, TX 79920 USA. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, 3400 Rawley E Chamber Ave, Ft Sam Houston, TX 78234 USA. EM andriy.batchinsky@amedd.army.mil NR 53 TC 14 Z9 14 U1 0 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD SEP PY 2007 VL 103 IS 3 BP 895 EP 902 DI 10.1152/japplphysiol.00563.2006 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 204OU UT WOS:000249054700023 PM 17569766 ER PT J AU Kiang, JG Bowman, PD Lu, XY Li, YS Wu, BW Loh, HH Tsen, KT Tsokos, GC AF Kiang, Juliann G. Bowman, Phillip D. Lu, Xinyue Li, Yansong Wu, Brian W. Loh, Horace H. Tsen, K. T. Tsokos, George C. TI Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article ID ORGAN DYSFUNCTION SYNDROME; GUT-LYMPH HYPOTHESIS; NEURONAL CELL-DEATH; HEAT-SHOCK PROTEINS; INFLAMMATORY RESPONSE; LUNG INJURY; PYRUVATE-DEHYDROGENASE; ENDOTHELIAL APOPTOSIS; TRAUMA-HEMORRHAGE; SMALL-INTESTINE AB Hemorrhage has been shown to increase inducible nitric oxide synthase (iNOS) and deplete ATP levels in tissues and geldanamycin limits both processes. Moreover, it is evident that inhibition of iNOS reduces caspase-3 and increases survival. Thus we sought to identify the molecular events responsible for the beneficial effect of geldanamycin. Hemorrhage in mice significantly increased caspase-3 activity and protein while treatment with geldanamycin significantly limited these increases. Similarly, geldanamycin inhibited increases in proteins forming the apoptosome (a complex of caspase-9, cytochrome c, and Apaf-1). Modulation of the expression of iNOS by iNOS gene transfection or siRNA treatment demonstrated that the level of iNOS correlates with caspase-3 activity. Our data indicate that geldanamycin limits caspase-3 expression and protects from organ injury by suppressing iNOS expression and apoptosome formation. Geldanamycin, therefore, may prove useful as an adjuvant in fluids used to treat patients suffering blood loss. C1 Uniformed Serv Univ Hlth Sci, Sci Res Dept, Armed Forces Radiobiol Res Inst, Bethesda, MD 20889 USA. Uniformed Serv Univ Hlth Sci, Dept Radiat Biol, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Med & Pharmacol, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD USA. USA, Inst Surg Res, San Antonio, TX USA. Univ Minnesota, Sch Med, Dept Pharmacol, Annapolis, MD USA. Arizona State Univ, Dept Phys & Astron, Tempe, AZ 85287 USA. Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA. RP Kiang, JG (reprint author), Uniformed Serv Univ Hlth Sci, Sci Res Dept, Armed Forces Radiobiol Res Inst, BLDG 46,Rm 2423,8901 Wisconsis Ave, Bethesda, MD 20889 USA. EM kiang@afrri.usuhs.mil NR 45 TC 15 Z9 17 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD SEP PY 2007 VL 103 IS 3 BP 1045 EP 1055 DI 10.1152/japplphysiol.00100.2007 PG 11 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 204OU UT WOS:000249054700043 PM 17525298 ER PT J AU He, JK Kuschner, RA Dewar, V Voet, P Asher, LV Vaughn, DW AF He, Junkun Kuschner, Robert A. Dewar, Vincent Voet, Pierre Asher, Ludmila V. Vaughn, David W. TI Characterization of monoclonal antibodies to hepatitis E virus (HEV) capsid protein and identification of binding activity SO JOURNAL OF BIOMEDICAL SCIENCE LA English DT Article DE hepatitis E virus (HEV); monoclonal antibodies; HEV capsid protein ID NEUTRALIZATION; VACCINE; PROTECTION; EPIDEMIC; SEQUENCE; ISOLATE; SERUM; PCR AB Twenty-seven monoclonal antibodies (Mabs) recognizing the open reading frame 2 structural protein of the Pakistan strain of hepatitis E virus (HEV) were generated by conventional hybridoma technique. These Mabs were characterized by ELISA, affinity-capture reverse transcriptase-polymerase chain reaction (AC/RT-PCR), immune electron microscopy (IEM), and a RT-PCR based seroneutralization assay. Twenty-seven Mabs were positive by ELISA. By AC/RT-PCR, 24 Mabs bound to Pakistan and Namibia HEV strains. Thirteen Mabs were examined by IEM. Nine Mabs, positive by ELISA and AC/RT-PCR, bound and aggregated to Mexican HEV strain. We tested five Mabs that were positive by ELISA, AC/RT/PCR, and IEM by a RT-PCR based seroneutralization assay. Only one Mab (Mab 7) showed activity that inhibited the ability of HEV to attach to Alexander hepatoma cells (PLC-PRF-5). When Mab 7 was diluted to 1: 160, its inhibition activity persisted suggesting that Mab 7 might be a potential candidate for further evaluation in primates (passive protection experiments). C1 Armed Forces Inst Pathol, Rockville, MD 20850 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. GlaxoSmithKline Biol, Rixensart, Belgium. Glaxo SmithKline, King Of Prussia, PA 19406 USA. RP He, JK (reprint author), Armed Forces Inst Pathol, 1413 Res Blvd, Rockville, MD 20850 USA. EM junkun.he@afip.osd.mil NR 33 TC 9 Z9 9 U1 0 U2 0 PU NATL SCIENCE COUNCIL, TAIPEI PI TAIPEI PA 106 HO-PING E RD, SEC 2, TAIPEI 10622, TAIWAN SN 1021-7770 J9 J BIOMED SCI JI J. Biomed. Sci. PD SEP PY 2007 VL 14 IS 5 BP 555 EP 563 DI 10.1007/s11373-007-9172-4 PG 9 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA 210HC UT WOS:000249446300002 PM 17487571 ER PT J AU Evans, RK Antczak, AJ Lester, ME Yanovich, R Israelli, E Moran, DS AF Evans, R. K. Antczak, A. J. Lester, M. E. Yanovich, R. Israelli, E. Moran, D. S. TI Bone turnover response of men and women to a strenuous gender-integrated recruit training regimen SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Meeting Abstract CT 29th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research CY SEP 16-19, 2007 CL Honolulu, HI SP Amer Soc Bone & Mineral Res C1 [Evans, R. K.; Antczak, A. J.; Lester, M. E.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Yanovich, R.; Israelli, E.; Moran, D. S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC BONE & MINERAL RES PI WASHINGTON PA 2025 M ST, N W, STE 800, WASHINGTON, DC 20036-3309 USA SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD SEP PY 2007 VL 22 SU 1 MA W487 BP S487 EP S487 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 225IA UT WOS:000250509102573 ER PT J AU Jackson, WM Koehler, SM Giuliani, JR Tuan, RS Nesti, LJ AF Jackson, W. M. Koehler, S. M. Giuliani, J. R. Tuan, R. S. Nesti, L. J. TI Progenitor cells in traumatically injured muscle have characteristic similarities to bone marrow-derived stem cells SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Meeting Abstract CT 29th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research CY SEP 16-19, 2007 CL Honolulu, HI SP Amer Soc Bone & Mineral Res C1 [Jackson, W. M.; Koehler, S. M.; Tuan, R. S.] NIAMSD, Cartilage Biol & Orthopaed Branch, Bethesda, MD 20892 USA. [Giuliani, J. R.; Nesti, L. J.] Walter Reed Army Med Ctr, Dept Orthopaed, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC BONE & MINERAL RES PI WASHINGTON PA 2025 M ST, N W, STE 800, WASHINGTON, DC 20036-3309 USA SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD SEP PY 2007 VL 22 SU 1 MA W039 BP S372 EP S372 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 225IA UT WOS:000250509102126 ER PT J AU Lester, ME Evans, RK Kraemer, WJ Staab, JS Pierce, JR Catrambone, DE Isome, HM Urso, ML Spiering, BA Hatfield, DL Maresh, CM Nindl, BC AF Lester, M. E. Evans, R. K. Kraemer, W. J. Staab, J. S. Pierce, J. R. Catrambone, D. E. Isome, H. M. Urso, M. L. Spiering, B. A. Hatfield, D. L. Maresh, C. M. Nindl, B. C. TI Bone biomarker responses to short-term training: Influence of exercise mode vs. osteogenic index SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Meeting Abstract CT 29th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research CY SEP 16-19, 2007 CL Honolulu, HI SP Amer Soc Bone & Mineral Res C1 [Lester, M. E.; Evans, R. K.; Staab, J. S.; Pierce, J. R.; Catrambone, D. E.; Isome, H. M.; Urso, M. L.; Nindl, B. C.] US Army Res Inst Environm Med, Milit Performance Div, Natick, MA USA. [Kraemer, W. J.; Spiering, B. A.; Hatfield, D. L.; Maresh, C. M.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC BONE & MINERAL RES PI WASHINGTON PA 2025 M ST, N W, STE 800, WASHINGTON, DC 20036-3309 USA SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD SEP PY 2007 VL 22 SU 1 MA W056 BP S376 EP S376 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 225IA UT WOS:000250509102143 ER PT J AU Pursell, DP AF Pursell, David P. TI Predicted versus actual performance in undergraduate organic chemistry and implications for student advising SO JOURNAL OF CHEMICAL EDUCATION LA English DT Article ID ACTIVE LEARNING-ENVIRONMENT; GENERAL-CHEMISTRY; GRADES; LAB C1 Georgia Gwinnett Coll, Sch Sci & Technol, Lawrenceville, GA 30043 USA. US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Pursell, DP (reprint author), Georgia Gwinnett Coll, Sch Sci & Technol, Lawrenceville, GA 30043 USA. EM dpursell@ggc.usg.edu NR 30 TC 5 Z9 5 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD SEP PY 2007 VL 84 IS 9 BP 1448 EP 1452 PG 5 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA 202ZK UT WOS:000248943700018 ER PT J AU Horvath, LL George, BJ Hospenthal, DR AF Horvath, Lynn L. George, Benjamin J. Hospenthal, Duane R. TI Detection of fifteen species of Candida in an automated blood culture system SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID SECULAR TRENDS; UNITED-STATES; EPIDEMIOLOGY; BACTEC-9240; INFECTIONS; BOTTLES; SURVEILLANCE; INCUBATION; HOSPITALS; GROWTH AB Candidemia was simulated with 15 Candida spp. by using an automated blood culture system. Candida growth was detected in 479/648 (74%) bottles: 211/216 (98%) aerobic bottles, 58/216 (27%) anaerobic bottles, and 210/216 (97%) mycology bottles. Only the growth of Candida lipolytica failed to be detected in all media. C1 Brooke Army Med Ctr, Infect Dis Serv, Dept Med, Ft Sam Houston, TX 78234 USA. RP Horvath, LL (reprint author), Brooke Army Med Ctr, Infect Dis Serv, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Lynn.Horvath@amedd.army.mil NR 23 TC 29 Z9 31 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD SEP PY 2007 VL 45 IS 9 BP 3062 EP 3064 DI 10.1128/JCM.00966-07 PG 3 WC Microbiology SC Microbiology GA 211EK UT WOS:000249506900047 PM 17626176 ER PT J AU Zufelt, JE AF Zufelt, Jon E. TI Editor's note SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Editorial Material C1 USA Corps Engineers, ERDC, CRREL, Anchorage Off, Ft Richardson, AK USA. RP Zufelt, JE (reprint author), USA Corps Engineers, ERDC, CRREL, Anchorage Off, POB 5646, Ft Richardson, AK USA. EM jon.e.zufelt@erdc.usace.army.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD SEP PY 2007 VL 21 IS 3 BP 69 EP 71 DI 10.1061/(ASCE)0887-381X(2007)21:3(69) PG 3 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 201EV UT WOS:000248815200001 ER PT J AU Dutta, M Stroscio, MA Vasudev, M Ramadurai, D Torres, L West, BJ AF Dutta, Mitra Stroscio, Michael A. Vasudev, Milana Ramadurai, Dinakar Torres, Leianne West, Bruce J. TI Blinking mechanism of colloidal semiconductor quantum dots: Blinking mechanisms SO JOURNAL OF COMPUTATIONAL ELECTRONICS LA English DT Article DE Double-layer potential; Levy distribution; Quantum dots; Blinking AB Nanoscale semiconductor quantum dots in colloidal suspensions are observed to blink with off times, tau(off), that scale as 1/tau(3/2)(off). In this paper, it is shown by relating the fluctuations of the surface charge density on the quantum dot to fluctuations in the double layer potential, that the related fluctuations in the barrier potential have exactly the functional form needed to result in an inverse-power-law distribution for off times. C1 [Dutta, Mitra; Stroscio, Michael A.] Univ Illinois, Nano Engn Res Lab, Elect & Comp Engn Dept, Chicago, IL 60607 USA. [Dutta, Mitra; Stroscio, Michael A.] Univ Illinois, Nano Engn Res Lab, Dept Phys, Chicago, IL 60607 USA. [Vasudev, Milana; Ramadurai, Dinakar; Torres, Leianne] Univ Illinois, Nano Engn Res Lab, BioEngn Dept, Chicago, IL 60607 USA. [West, Bruce J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Stroscio, MA (reprint author), Univ Illinois, Nano Engn Res Lab, Elect & Comp Engn Dept, Chicago, IL 60607 USA. EM stroscio@uic.edu NR 13 TC 3 Z9 4 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1569-8025 J9 J COMPUT ELECTRON JI J. Comput. Electron. PD SEP PY 2007 VL 6 IS 1-3 SI SI BP 301 EP 304 DI 10.1007/s10825-006-0120-8 PN 2 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA V25JF UT WOS:000208473600073 ER PT J AU Osswald, SS Kulick, KB Tomaszewski, MM Sperling, LC AF Osswald, Sandra S. Kulick, Kevin B. Tomaszewski, Maria-Magdalena Sperling, Leonard C. TI Viral-associated trichodysplasia in a patient with lymphoma: a case report and review SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Review ID SPINULOSA AB Viral-associated trichodysplasia is a recently described entity associated with immunosuppression. We describe a 68-year-old man with a history of treated lymphoma who developed numerous, disfiguring, papular and spiny lesions involving most of the central face. Both facial and body alopecia was noted. Histopathologic findings of a facial papule showed dramatic alterations of the hair bulbs, including bulbar distention, lack of hair shaft formation and a marked expansion of inner root sheath type epithelium. These findings were identical to those of previously described cases, so electron microscopy was performed. Numerous intranuclear virus particles were identified. Shortly after the diagnosis of trichodysplasia was made, the patient was found to have a relapse of his lymphoma, which may represent the source of his immunosuppression. Based on his skin biopsy findings, successful antiviral therapy was initiated. This case and a review of previously reported cases are discussed in this study. Osswald SS, Kulick KB, Tomaszewski M-M, Sperling LC. Viral-associated trichodysplasia in a patient with lymphoma: a case report and review. (c) Blackwell Munksgaard 2007. C1 Brooke Army Med Ctr, USAF, Dept Dermatol, Ft Sam Houston, TX 78234 USA. SUNY Buffalo, Sch Med & Biomed Sci, Dept Dermatol, Buffalo, NY 14260 USA. Armed Forces Inst Pathol, Dept Dermatopathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Dept Dermatol, Bethesda, MD 20814 USA. RP Osswald, SS (reprint author), Brooke Army Med Ctr, USAF, Dept Dermatol, Ft Sam Houston, TX 78234 USA. EM ssosswald@aol.com NR 6 TC 35 Z9 35 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD SEP PY 2007 VL 34 IS 9 BP 721 EP 725 DI 10.1111/j.1600-0560.2006.00693.x PG 5 WC Dermatology; Pathology SC Dermatology; Pathology GA 203IR UT WOS:000248968800010 PM 17696921 ER PT J AU Johnson, TM Badovinac, R Shaefer, J AF Johnson, Thomas M. Badovinac, Rachel Shaefer, Jeffry TI Teaching alternatives to the standard inferior alveolar nerve block in dental education: Outcomes in clinical practice SO JOURNAL OF DENTAL EDUCATION LA English DT Article DE local anesthesia; inferior alveolar nerve block; Gow-Gates mandibular block; Akinosi mandibular block ID MANDIBULAR BLOCK; ANESTHESIA; INJECTION AB Surveys were sent to Harvard School of Dental Medicine students and graduates from the classes of 2000 through 2006 to determine their current primary means of achieving mandibular anesthesia. Orthodontists and orthodontic residents were excluded. All subjects received clinical training in the conventional inferior alveolar nerve block and two alternative techniques (the Akinosi mandibular block and the Gow-Gates mandibular block) during their predoctoral dental education. This study tests the hypothesis that students and graduates who received training in the conventional inferior alveolar nerve block, the Akinosi mandibular block, and the Gow-Gates mandibular block will report more frequent current utilization of alternatives to the conventional inferior alveolar nerve block than clinicians trained in the conventional technique only. At the 95 percent confidence level, we estimated that between 3.7 percent and 16.1 percent (mean=8.5 percent) of clinicians trained in using the Gow-Gates technique use this injection technique primarily, and between 35.4 percent and 56.3 percent (mean=47.5 percent) of those trained in the Gow-Gates method never use this technique. At the same confidence level, between 0.0 percent and 3.8 percent (mean=0.0 percent) of clinicians trained in using the Akinosi technique use this injection clinical technique primarily, and between 62.2 percent and 81.1 percent (mean=72.3 percent) of those trained in the Akinosi method never use this technique. No control group that was completely untrained in the Gow-Gates or Akinosi techniques was available for comparison. However, we presume that zero percent of clinicians who have not been trained in a given technique will use the technique in clinical practice. The confidence interval for the Gow-Gates method excludes this value, while the confidence interval for the Akinosi technique includes zero percent. We conclude that, in the study population, formal clinical training in the Gow-Gates and Akinosi injection techniques lead to a small but significant increase in current primary utilization of the Gow-Gates technique. No significant increase in current primary utilization of the Akinosi technique was found. C1 USA, Peridont Residency, Tingay Dent Clin, Ft Gordon, GA 30905 USA. Harvard Univ, Sch Dent Med, Dept Oral Surg, Cambridge, MA 02138 USA. RP Johnson, TM (reprint author), USA, Peridont Residency, Tingay Dent Clin, Bldg 320, Ft Gordon, GA 30905 USA. EM thomas.johnson@us.army.mil NR 15 TC 7 Z9 8 U1 1 U2 3 PU AMER DENTAL EDUCATION ASSOC PI WASHINGTON PA 1400 K STREET, NW, STE 1100, WASHINGTON, DC 20005 USA SN 0022-0337 J9 J DENT EDUC JI J. Dent. Educ. PD SEP PY 2007 VL 71 IS 9 BP 1145 EP 1152 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 217CO UT WOS:000249926200002 PM 17761620 ER PT J AU McDonald, KW Glen, LA AF McDonald, Kenneth W. Glen, Andrew TI Modeling military trampling effects on glacial soils in the humid continental climate of southern New York SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE soil compaction; math modeling; trampling; bulk density; military training; West Point ID VEGETATION; RECOVERY; FOREST AB The purpose of this research is to create a baseline model of soil compaction response to trampling and a methodology to model the effects of trampling on soil. Although trampling studies have been conducted in the past, the analysis of military training in part provides a different perspective and approach. The data showed bulk densities remained relatively constant for a time and then began to increase at an increasing rate for several hundred passes and finally leveled and remained at or below 1.30g/cm(3) through the remainder of the experiment. Mathematical models were created based on empirical data from a trampling experiment using a more standard logistical growth curve as well as curves based on Weibull and gamma cumulative distribution functions (CDFs). The experiment and the resulting models give quantifiable continuous inference on the effects of trampling, as opposed to the existing qualitative assessments. These baseline models will be the foundation for future studies of land management when trampling occurs. (C) 2006 Elsevier Ltd. All rights reserved. C1 US Mil Acad, Dept Civil Engn & Mech, West Point, NY 10996 USA. US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP McDonald, KW (reprint author), US Mil Acad, Dept Civil Engn & Mech, Bldg 752,Maham Hall, West Point, NY 10996 USA. EM ik6124@usma.edu NR 24 TC 2 Z9 2 U1 0 U2 3 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD SEP PY 2007 VL 84 IS 4 BP 377 EP 383 DI 10.1016/j.jenvman.2006.06.012 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 196UW UT WOS:000248508700001 PM 17400360 ER PT J AU Liu, LB Albert, DG Wilson, DK AF Liu, Lanbo Albert, Donald G. Wilson, D. Keith TI The effect of changing scatterer positions on acoustic time-reversal refocusing in a 2D urban environment at low frequencies SO JOURNAL OF GEOPHYSICS AND ENGINEERING LA English DT Article DE acoustic wave propagation; time reversal; scattering; source detection; numerical; modelling; urban environment ID SOUND-PROPAGATION; MAXWELLS EQUATIONS; FINITE-DIFFERENCE; MEDIA; IMPLEMENTATION; WAVES; OCEAN AB In a previous work, we considered time-reversal refocusing for localizing a sound source in a highly reverberant urban environment with non-line-of-sight (NLOS) receivers. The approach involved a virtual (computer-based) time-reversal propagation calculation using a priori knowledge of the receiver and scatterer positions. Among the errors that affect the quality of refocusing is the imperfect accuracy of the assumed scatterer locations. Some practical analogues of changing scatterer positions are ( a) the building coordinate errors ( or mistakes) and (b) the random movement of vehicles on the street of an urban setting. We address these issues by conducting a time-reversal analysis of a set of numerically generated synthetic acoustic pressure recordings after intentionally introducing errors by altering the position of the scatterers. The numerical experiment results indicate that, for a realistically complicated urban setting, coordinate errors in the position of only a few scatterers have little detrimental effect. The effect of coordinate errors in one or a few scatterers is suppressed by the constraints imposed by correct propagation features ( both kinematic and dynamic) generated by multiple reflections and diffractions from other precisely located scatterers. The dependence of source localization accuracy on the relative error in scatterer coordinates, the relative number of scatterers with coordinate errors and the number of receivers is quantitatively assessed in this paper. In general, time-reversal refocusing with a large number of receivers can compensate for more severe errors. Even for only three non-line-of-sight receivers, building location errors in the order of 3 m still give good results. Adding small scatterers ( like vehicles) close to a receiver is more critical than adding scatterers relatively far from the receivers. C1 Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. ERDC, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Liu, LB (reprint author), Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. EM Lanbo.Liu@uconn.edu RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 20 TC 10 Z9 10 U1 1 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1742-2132 J9 J GEOPHYS ENG JI J. Geophys. Eng. PD SEP PY 2007 VL 4 IS 3 BP 276 EP 284 DI 10.1088/1742-2132/4/3/S06 PG 9 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 206ZV UT WOS:000249222300006 ER PT J AU Moss, RES Seed, RB Olsen, RS AF Moss, R. E. S. Seed, R. B. Olsen, R. S. TI Closure to "Normalizing the CPT for overburden stress" by R. E. S. Moss, R. B. Seed, and R. S. Olsen SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Editorial Material C1 Calif Polytech State Univ San Luis Obispo, Dept Civil & Environm Engn, San Luis Obispo, CA 93407 USA. Univ Calif Berkeley, Dept Civil & Environm Engn, Berkeley, CA 94720 USA. USA, ERDC, WES, Vicksburg, MS 39108 USA. RP Moss, RES (reprint author), Calif Polytech State Univ San Luis Obispo, Dept Civil & Environm Engn, San Luis Obispo, CA 93407 USA. EM rmoss@calpoly.edu RI Moss, Robb/N-7376-2014 NR 0 TC 0 Z9 0 U1 0 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD SEP PY 2007 VL 133 IS 9 BP 1177 EP 1177 DI 10.1061/(ASCE)1090-0241(2007)133:9(1177) PG 1 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 201FG UT WOS:000248816300016 ER PT J AU Duan, JG Scott, S AF Duan, Jennifer G. Scott, Steve TI Selective bed-load transport in Las Vegas Wash, a gravel-bed stream SO JOURNAL OF HYDROLOGY LA English DT Article DE sediment transport; bed load transport; gravel-bed rivers; field hydrology; bi-modal sediment ID MIXED-SIZE SEDIMENT; BEDLOAD TRANSPORT; RIVERS; SAND; EVOLUTION; MOBILITY; RATES AB Bed-load measurements collected at the Las Vegas Wash, a gravel-bed stream near Las Vegas, Nevada, were used to study selective transport of sand and gravel in uni-modal or weakly bi-modal river sediment. Measurements showed that size selectivity in a sediment mixture decreases as shear stress increases. Transport of variously sized sediment particles approaches equal mobility as the transported bed load is composed approximately of the same size particles as surface-bed material. Consequently, a hiding function was derived to account for the increase or reduction in reference shear stress for an individual size class in a sediment mixture as compared with that in an uniformly sized sediment. An empirical equation for determining fractional bed-load transport rate was then formulated by correlating the dimensionless, fractional bed-load transport rate with the dimensionless bed-shear stress. This equation indicated that the hiding function depends not only on the size of individual size class but also on the flow depth used to quantify the magnitude of shear stress. The present study contributes to the body of knowledge used in predicting selective transport of sediment mixtures in gravel-bed streams. (C) 2007 Elsevier B.V. All rights reserved. C1 Univ Arizona, Dept Civil Engn & Mech, Tucson, AZ 85721 USA. USA, Corps Engineers, Ctr Res Dev & Engn, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Duan, JG (reprint author), Univ Arizona, Dept Civil Engn & Mech, Tucson, AZ 85721 USA. EM gduan@email.arizona.edu; Steve.H.Scott@erdc.usace.army.mil NR 36 TC 12 Z9 12 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 J9 J HYDROL JI J. Hydrol. PD SEP 1 PY 2007 VL 342 IS 3-4 BP 320 EP 330 DI 10.1016/j.jhydrol.2007.06.001 PG 11 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 206IN UT WOS:000249177200010 ER PT J AU Heine, HS Louie, A Sorgel, F Bassett, J Miller, L Sullivan, LJ Kinzig-Schippers, M Drusano, GL AF Heine, Henry S. Louie, Arnold Sorgel, Fritz Bassett, Jennifer Miller, Lynda Sullivan, Lawrence J. Kinzig-Schippers, Martina Drusano, George L. TI Comparison of 2 antibiotics that inhibit protein synthesis for the treatment of infection with Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID STAPHYLOCOCCUS-AUREUS AB Introduction. Intentional release of Yersinia pestis will likely be propagated by aerosol exposure. We explored the effects of neutropenia on the outcome of doxycycline and gentamicin therapy. Methods. Female BALB/c mice were exposed to 20 LD50 of Y. pestis CO92 by aerosol. Treatments were saline (negative control), levofloxacin at 15 mg/kg every 12 h (positive control), doxycycline at 40 mg/kg every 6 h, and gentamicin at 12 mg/kg every 6 h, 24 mg/kg every 12 h, and 48 mg/kg every 24 h in cohorts of normal and neutropenic mice for 5 days. Results. Control mice died. Positive control mice ( levofloxacin) had 100% survivorship in both neutropenic and nonneutropenic groups. Doxycycline treatment in the presence of granulocytes yielded 90% survivorship; all neutropenic mice died after the termination of treatment (P << .001). For gentamicin, survivorship of mice receiving drug every 24, 12, and 6 h was, respectively, 80%, 80%, and 90% for normal mice and 80%, 100%, and 70% for neutropenic mice. No significant differences were seen in the neutropenia versus normal mouse comparison or by schedule. Conclusions. Doxycycline behaves in vivo as a bacteriostatic drug, requiring an intact immune system for clearance of the infection after aerosol challenge with Y. pestis. Gentamicin is bactericidal, even when given on a daily schedule. Neutropenia did not significantly affect survivorship. C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. Ordway Res Inst, Albany, NY USA. Inst Biomed & Pharmaceut Res, Nurnberg, Germany. RP Heine, HS (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM henry.heine@amedd.army.mil FU NIAID NIH HHS [1 PO1 AI060908-01A1] NR 20 TC 16 Z9 17 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD SEP 1 PY 2007 VL 196 IS 5 BP 782 EP 787 DI 10.1086/520547 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 197LS UT WOS:000248557600019 PM 17674322 ER PT J AU Das, S Cox, DF Wilkes, GL Klinedinst, DB Yilgor, I Yilgor, E Beyer, FL AF Das, Sudipto Cox, David F. Wilkes, Garth L. Klinedinst, Derek B. Yilgor, Iskender Yilgor, Emel Beyer, Frederick L. TI Effect of symmetry and H-bond strength of hard segments on the structure-property relationships of segmented, nonchain extended polyurethanes and polyureas SO JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS LA English DT Article DE polyurethanes; polyurea; hydrogen bonding; nanostructure; chain symmetry; self assembly; TPU; microphase separation ID BLOCK LENGTH DISTRIBUTION; SILOXANE UREA COPOLYMERS; ANGLE X-RAY; ORGANOSILOXANE COPOLYMERS; THERMOPLASTIC ELASTOMERS; MORPHOLOGY DEVELOPMENT; MECHANICAL-PROPERTIES; COPOLY(ETHER UREA)S; MOLECULAR-WEIGHT; BEHAVIOR AB Segmented, nonchain extended polyurethanes and polyureas based on PTMO soft segments (SS) anti hard segments (HSs) based on only single molecules of a diisocyanate were synthesized. Type and nature of the diisocyanate was systematically varied in order to analyze the effect of HS symmetry and type of linkage between the HS and SS on the structure-property relationship of these segmented copolymers. Results showed that the increased symmetry of the diisocyanates allows a more efficient packing of the HSs which leads to a microphase-separated structure with the crystalline hard ribbon or thread-like domains percolated throughout the SS matrix, even with a low HS content (ca. 13 wt.%). The service window of these segmented copolymers was significantly influenced by the symmetry and type of linkage between the HS and SS. Most copolymers also showed evidence of strain hardening accented by the strain induced crystallization of the PTMO SS. C1 Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA. Virginia Tech, Dept Mat Sci & Engn, Blacksburg, VA USA. Koc Univ, Dept Chem, Istanbul, Turkey. USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Wilkes, GL (reprint author), Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA. EM gwilkes@vt.edu NR 41 TC 32 Z9 32 U1 5 U2 38 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0022-2348 J9 J MACROMOL SCI B JI J. Macromol. Sci. Part B-Phys. PD SEP-OCT PY 2007 VL 46 IS 5 BP 853 EP 875 DI 10.1080/00222340701388805 PG 23 WC Polymer Science SC Polymer Science GA 211AE UT WOS:000249495900002 ER PT J AU Kulkarni, RR Chawla, KK Vaidya, UK Sands, JM AF Kulkarni, Rahul R. Chawla, Krishan K. Vaidya, Uday K. Sands, James M. TI Thermal stresses in aluminum 6061 and nylon 66 long fiber thermoplastic (LFT) composite joint in a tailcone SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID INFRARED THERMOGRAPHY; RESIDUAL-STRESSES; HEAT-TRANSFER; METAL AB The present paper involves a metal/polymer joint in a tailcone in a kinetic energy penetrator (KEP), one of the ammunition types used by the military. It is currently made of aluminum 7075 alloy, which could be partly replaced by long fiber thermoplastic (LFT) composite. Two different types of aluminum insert geometries were considered, viz., beaded and threaded. Thermal stresses set in during cooling of the tailcone from the processing temperature mainly because of the difference in the values of coefficients of thermal expansion and differential cooling between the aluminum and the LFT composite. Finite element (FE) modeling was done to predict the temperature profile during the cooling of the tailcone from the processing temperature. FE results showed that the LFT composite part of the tailcone cooled faster than the aluminum insert. Experimental verification of this temperature profile was obtained by infrared (IR) thermography. Based on the temperature profile, thermal stresses at the metal/LFT composite interface were estimated using an FE model. Different magnitudes of thermal stresses were present at the aluminum/LFT composite interface owing to the nature of distribution of fibers around the insert. Magnitude of thermal stresses in the case of a beaded insert was approximately 2.5 MPa whereas in the case of a threaded insert, it was approximately 12 MPa. C1 Univ Alabama, Dept Mat Sci & Engn, Birmingham, AL 35294 USA. USA, Res Labs, Aberdeen Proving Ground, MD 21005 USA. RP Chawla, KK (reprint author), Univ Alabama, Dept Mat Sci & Engn, 1530 3rd Ave S,BEC 254, Birmingham, AL 35294 USA. EM kchawla@uab.edu NR 16 TC 3 Z9 3 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD SEP PY 2007 VL 42 IS 17 BP 7389 EP 7396 DI 10.1007/s10853-007-1840-2 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 188QQ UT WOS:000247934800049 ER PT J AU Peker, AS Lavery, JE Fang, SC AF Peker, A. S. Lavery, J. E. Fang, S.-C. TI A reduced Hsieh-Clough-Tocher element with splitting based on an arbitrary interior point SO JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS LA English DT Article DE Bernstein-Bezier; Clough-Tocher element; reduced Hsieh-Clough-Tocher element; splitting; subtriangle; triangle ID INTERPOLATION AB We present formulas for a reduced Hsieh-Clough-Tocher (rHCT) element with splitting based on an arbitrary interior point. These formulas use local barycentric coordinates in each of the subtriangles and are not significantly more complicated than formulas for an rHCT element with splitting based on the centroid. (c) 2006 Elsevier Inc. All rights reserved. C1 N Carolina State Univ, Raleigh, NC 27695 USA. USA, Res Off, Army Res Lab, Div Math, Res Triangle Pk, NC 27709 USA. Tsing Hua Univ, Dept Math Sci, Beijing 100084, Peoples R China. RP Peker, AS (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA. EM aspeker@ncsu.edu; john.lavery2@us.army.mil; fang@ncsu.edu NR 10 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-247X J9 J MATH ANAL APPL JI J. Math. Anal. Appl. PD SEP 1 PY 2007 VL 333 IS 1 BP 500 EP 504 DI 10.1016/j.jmaa.2006.12.030 PG 5 WC Mathematics, Applied; Mathematics SC Mathematics GA 179YG UT WOS:000247325900032 ER PT J AU Waits, CM Geil, B Ghodssi, R AF Waits, C. Mike Geil, Bruce Ghodssi, Reza TI Encapsulated ball bearings for rotary micro machines SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article; Proceedings Paper CT 6th International Workshop on Micro and Nanotechnologies for Power Generation and Energy Conversion Applications CY 2006 CL Berkeley, CA AB We report on the first encapsulated rotary ball bearing mechanism using silicon microfabrication and stainless steel balls. The method of capturing stainless steel balls within a silicon race to support a silicon rotor both axially and radially is developed for rotary micro machines and MEMS ball bearing tribology studies. Initial demonstrations show speeds up to 6.8 krpm without lubrication, while speeds up to 15.6 krpm with lubrication are possible. Qualitative analysis is used to explain start-up behavior and investigate the wear of the stainless steel ball and silicon race. C1 Inst Syst Res, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Waits, CM (reprint author), Inst Syst Res, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA. EM ghodssi@umd.edu NR 9 TC 16 Z9 17 U1 0 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD SEP PY 2007 VL 17 IS 9 BP S224 EP S229 DI 10.1088/0960-1317/17/9/S03 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 206ZW UT WOS:000249222400004 ER PT J AU Hong, HP Zheng, YS Roy, W AF Hong, Haiping Zheng, Yingsong Roy, Walter TI Nanomaterials for efficiently lowering the freezing point of anti-freeze coolants SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article DE nanomaterial; carbon nanotube; freezing point ID THERMAL-CONDUCTIVITY ENHANCEMENT; CARBON NANOTUBES; AQUEOUS SUSPENSIONS; NANOFLUIDS; NANOPARTICLES AB In this paper, we report, for the first time, the effect of the lowered freezing point in a 50% water/50% anti-freeze coolant (PAC) or 50% water/50% ethylene glycol (EG) solution by the addition of carbon nanotubes and other particles. The experimental results indicated that the nano materials are much more efficient (hundreds fold) in lowering the freezing point than the regular ionic materials (e.g., NaCl). The possible explanation for this interesting phenomenon is the colligative property of fluid and relative small size of nano material. It is quite certain that the carbon nanotubes and metal oxide nano particles could be a wonderful candidate for the nano coolant application because they could not only increase the thermal conductivity, but also efficiently lower the freezing point of traditional coolants. C1 S Dakota Sch Mines & Technol, Rapid City 57701, SD USA. USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Hong, HP (reprint author), S Dakota Sch Mines & Technol, Rapid City 57701, SD USA. NR 22 TC 6 Z9 7 U1 0 U2 9 PU AMER SCIENTIFIC PUBLISHERS PI STEVENSON RANCH PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA SN 1533-4880 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD SEP PY 2007 VL 7 IS 9 BP 3180 EP 3184 DI 10.1166/jnn.2007.662 PG 5 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 223QW UT WOS:000250388400021 PM 18019146 ER PT J AU Steinbeck, MJ Nesti, LJ Sharkey, PF Parvizi, J AF Steinbeck, Maria J. Nesti, Leon J. Sharkey, Peter F. Parvizi, Javad TI Myeloperoxidase and chlorinated peptides in osteoarthritis: Potential biornarkers of the disease SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article DE myeloperoxidase; chlorinated peptides; osteoarthritis; biomarkers ID HUMAN-NEUTROPHILS; INFLAMMATION; MARKERS; TISSUE; KNEE; ANGIOGENESIS; OXIDATION; PROTEIN AB Osteoarthritis (OA) is a disabling condition in which multiple initiating events or conditions (heritable and nonheritable) result in eventual loss of articular cartilage. However, the etiology of CA remains poorly understood, and diagnosis of early disease is difficult due to the lack of specific identifiers. Recent literature suggests that a series of inflammatory processes may be involved in initiating and propagating OA. We hypothesized that products of neutrophils and macrophages, namely myeloperoxidase (MPO), a specific enzyme responsible for the production of both highly reactive hypochlorous acid (HOCI) and chlorine gas (Cl-2) and chlorinated peptides, may be present in the synovial fluid of patients with OA. We examined the synovial fluid from 30 patients to identify and profile the presence of MPO. We divided the samples into three groups using radiographic and clinical assessment: (1) control, patients with acute knee injury with no history of CA and no radiographic evidence of OA; (2) early CA, patients with a mild OA based on radiographs; and (3) late CA, patients with a longstanding history of OA and with radiographic evidence of complete joint loss. Patients with early CA demonstrated significantly elevated levels of MPO. We also demonstrated the presence of HOCI and Cl-2 Modified proteins (Cl-peptides) in early CA synovial fluid samples by liquid chromatography and mass spectrometry. Patients in the control and advanced OA groups demonstrated little elevation in MPO levels and Cl-peptides were undetectable. These results indicate that MPO and Cl-peptides may serve as diagnostic markers for the detection of early OA. (c) 2007 Orthopaedic Research Society. C1 Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19107 USA. Walter Reed Army Med Ctr, Dept Orthopaed Surg, Washington, DC 20307 USA. Rothman Inst Orthoped, Philadelphia, PA 19107 USA. RP Steinbeck, MJ (reprint author), Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19107 USA. EM marla.steinbec@jefferson.edu FU NIDA NIH HHS [R29 DA011082]; NIDCR NIH HHS [R29 DE011082, R29 DE011082-06, R29 DE11082] NR 27 TC 81 Z9 82 U1 2 U2 12 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0736-0266 J9 J ORTHOP RES JI J. Orthop. Res. PD SEP PY 2007 VL 25 IS 9 BP 1128 EP 1135 DI 10.1002/jor.20400 PG 8 WC Orthopedics SC Orthopedics GA 202HS UT WOS:000248893200002 PM 17474133 ER PT J AU Ryan, PM Puttler, EG Stotler, WM Ferguson, RL AF Ryan, Paul M. Puttler, Eric G. Stotler, Wesley M. Ferguson, Ron L. TI Role of the triradiate cartilage in predicting curve progression in adolescent idiopathic scoliosis SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE adolescent idiopathic scoliosis; bracing; triradiate cartilage ID COBB ANGLE MEASUREMENT; WILMINGTON BRACE; RADIOGRAPHS AB Braces are commonly used to treat progressive adolescent idiopathic scoliosis. Several previous studies have reported a correlation between the success of brace treatment and skeletal maturity markers. These studies have not focused on the status of the triradiate cartilage (TRC) as it relates to successful brace treatment for adolescent idiopathic scoliosis. The authors retrospectively evaluated all patients at their institution from 1990 to 1997 with a diagnosis of adolescent idiopathic scoliosis who were treated in a Boston brace. Sixty-two patients met inclusion criteria. At presentation, the average age was 12.87 years, the average Risser sign was 0.56, and 45% of patients had an open TRC. The average follow-up was 2.92 years. Greater than 5 degrees of progression at discontinuation of bracing was considered a failure. Curves with a closed TRC failed bracing 21% of the time, whereas those with an open TRC failed 54% of the time (P = 0.0069). Those curves with a closed TRC progressed 3.12 degrees on average, whereas curves with an open TRC progressed 6.86 degrees. Curves associated with a closed TRC at initiation of bracing progressed less frequently and to a lesser degree than those associated with an open TRC (P = 0.027). Although the TRC is not an independent predictor of curve stability, it is an additional indicator of skeletal maturity and may prove most useful in patients with otherwise borderline indications for brace treatment. C1 [Ryan, Paul M.; Puttler, Eric G.] US Army Med Corp, Ft Lewis, WA USA. RP Ryan, PM (reprint author), CMR 442,Box 555, APO, AE 09042 USA. EM paul.m.ryan@us.army.mil NR 17 TC 4 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-6798 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD SEP PY 2007 VL 27 IS 6 BP 671 EP 676 PG 6 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA 299PC UT WOS:000255766500014 PM 17717469 ER PT J AU Wey, CC Anderson, BE Wey, C Miake-Lye, RC Whitefield, P Howard, R AF Wey, Chowen C. Anderson, Bruce E. Wey, Changlie Miake-Lye, Richard C. Whitefield, Philip Howard, Robert TI Overview on the aircraft particle emissions experiment SO JOURNAL OF PROPULSION AND POWER LA English DT Article AB Conducted at the NASA Dryden Flight Research Center during April 2004, the Aircraft Particle Emissions Experiment systematically investigated the gas-phase and particle emissions from a CFM56-2C1 engine on NASA's DC-8 aircraft as functions of engine power, fuel composition, and exhaust-plume age. Emissions parameters were measured at 11 engine power settings ranging from idle to maximum thrust, in samples collected 1, 10, and 30 m downstream of the exhaust plane as the aircraft burned three fuels with different aromatic and sulfur contents. The land 10-m sampling rakes contained multiple gas and particle inlet probes to facilitate a study of the spatial variation of emissions across the engine exhaust plane. Gas-phase emission indices measured at 1 m were in good agreement with the engine certification data as well as with predictions provided by the engine company. However, at low power settings, trace-species emissions were observed to be highly dependent on ambient conditions and engine temperature. Nonvolatile particles emitted by the engine exhibited a log-normal size distribution that peaked between 15 and 40 nm, depending on engine power. Samples collected 30 m downstream of the engine exit plane exhibited a prominent nucleation mode, indicating that secondary aerosols composed of sulfuric acid and low-volatility organic species formed rapidly within the plume as it expanded and cooled. Black carbon emissions were a minimum at approach and a maximum at climb and takeoff engine power settings. Black carbon dominated total mass emissions at high thrust, whereas volatile particles contributed an equal or perhaps greater fraction at low- to midpower settings. Although variations in fuel aromatic content had no discernible impact on particle emissions, volatile particle number and mass concentrations in aged exhaust plumes were highly sensitive to the fuel sulfur content. C1 USA, Res Lab, Cleveland, OH 44135 USA. NASA, Langley Res Ctr, Hampton, VA 23681 USA. QSS Grp Inc, Cleveland, OH 44135 USA. Aerodyne Res Inc, Billerica, MA 01821 USA. Univ Missouri, Rolla, MO 65409 USA. Arnold AF Base, Arnold Engn Dev Ctr, Tullahoma, TN 37389 USA. RP Wey, CC (reprint author), USA, Res Lab, Cleveland, OH 44135 USA. NR 18 TC 54 Z9 54 U1 1 U2 9 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD SEP-OCT PY 2007 VL 23 IS 5 BP 898 EP 905 DI 10.2514/1.26406 PG 8 WC Engineering, Aerospace SC Engineering GA 213MH UT WOS:000249671200002 ER PT J AU Pettit, CL Wilson, DK AF Pettit, Chris L. Wilson, D. Keith TI Proper orthogonal decomposition and cluster weighted modeling for sensitivity analysis of sound propagation in the atmospheric surface layer SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID UNCERTAINTY; TUTORIAL AB Outdoor sound propagation predictions are compromised by uncertainty and error in the atmosphere and terrain representations, and sometimes also by simplified or incorrect physics. A model's predictive power, i.e., its accurate representation of the sound propagation, cannot be assessed without first quantifying the ensemble sound pressure variability and sensitivity to uncertainties in the model's governing parameters. This paper describes fundamental steps toward this goal for a single-frequency point source. The atmospheric surface layer is represented through Monin-Obukhov similarity theory and the acoustic ground properties with a relaxation model. Sound propagation is predicted with the parabolic equation method. Governing parameters are modeled as independent random variables across physically reasonable ranges. Latin hypercube sampling and proper orthogonal decomposition (POD) are employed in conjunction with cluster-weighted models to develop compact representations of the sound pressure random field. Full-field sensitivity of the sound pressure field is computed via the sensitivities of the POD mode coefficients to the system parameters. Ensemble statistics of the full-field sensitivities are computed to illustrate their relative importance at every down range location. The central role of sensitivity analysis in uncertainty quantification of outdoor sound propagation is discussed and pitfalls of sampling-based sensitivity analysis for outdoor sound propagation are described. C1 USN Acad, Dept Aerosp Engn, Annapolis, MD 21402 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Pettit, CL (reprint author), USN Acad, Dept Aerosp Engn, 590 Holloway Rd,MS 11-B, Annapolis, MD 21402 USA. EM pettitcl@us.na.edu RI Pettit, Chris/A-1073-2010; Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 32 TC 6 Z9 6 U1 0 U2 3 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 2007 VL 122 IS 3 BP 1374 EP 1390 DI 10.1121/1.2756176 PG 17 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 208LV UT WOS:000249321700008 PM 17927400 ER PT J AU Vecherin, SN Ostashev, VE Ziemann, A Wilson, DK Arnold, K Barth, M AF Vecherin, Sergey N. Ostashev, Vladimir E. Ziemann, A. Wilson, D. Keith Arnold, K. Barth, M. TI Tomographic reconstruction of atmospheric turbulence with the use of time-dependent stochastic inversion SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ACOUSTIC TOMOGRAPHY; SURFACE-LAYER; BOUNDARY-LAYER; TOPEX/POSEIDON; CIRCULATION AB Acoustic travel-time tomography allows one to reconstruct temperature and wind velocity fields in the atmosphere. In a recently published paper [S. Vecherin et al., J. Acoust. Soc. Am. 119, 2579 (2006)], a time-dependent stochastic inversion (TDSI) was developed for the reconstruction of these fields from travel times of sound propagation between sources and receivers in a tomography array. TDSI accounts for the correlation of temperature and wind velocity fluctuations both in space and time and therefore yields more accurate reconstruction of these fields in comparison with algebraic techniques and regular stochastic inversion. To use TDSI, one needs to estimate spatial-temporal covariance functions of temperature and wind velocity fluctuations. In this paper, these spatial-temporal covariance functions are derived for locally frozen turbulence which is a more general concept than a widely used hypothesis of frozen turbulence. The developed theory is applied to reconstruction of temperature and wind velocity fields in the acoustic tomography experiment carried out by University of Leipzig, Germany. The reconstructed temperature and velocity fields are presented and errors in reconstruction of these fields are studied. (c) 2007 Acoustical Society of America. C1 New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. NOAA, Earth Syst Res Lab, Boulder, CO 80305 USA. Univ Leipzig, Inst Meteorol, D-04103 Leipzig, Germany. USA, Engn Res & Dev Ctr, Hanover, NH 03755 USA. Univ Leipzig, D-04109 Leipzig, Germany. RP Vecherin, SN (reprint author), New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 23 TC 19 Z9 19 U1 0 U2 1 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 2007 VL 122 IS 3 BP 1416 EP 1425 DI 10.1121/1.2756798 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 208LV UT WOS:000249321700011 PM 17927403 ER PT J AU Driscoll, IR Hwang, PF Fuenfer, MM Shriver, CD Stojadinovic, A Aydelotte, JD AF Driscoll, Ian R. Hwang, Paul F. Fuenfer, Michael M. Shriver, Craig D. Stojadinovic, Alexander Aydelotte, Jayson D. TI High velocity penetrating wounds to the neck: Lessons learned from the battlefields in Afghanistan and Iraq SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 93rd Annual Clinical Congress of the American-College-of-Surgeons CY OCT 07-11, 2007 CL New Orleans, LA SP Amer Coll Surg C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2007 VL 205 IS 3 SU S BP S67 EP S67 DI 10.1016/j.jamcollsurg.2007.06.168 PG 1 WC Surgery SC Surgery GA 209OG UT WOS:000249397300144 ER PT J AU White, JO Dubinskii, M Merkle, LD Kudryashov, I Garbuzov, D AF White, Jeffrey O. Dubinskii, Mark Merkle, Larry D. Kudryashov, Igor Garbuzov, Dmitri TI Resonant pumping and upconversion in 1.6 mu m Er3+ lasers SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID YAG LASER; ABSORPTION INTENSITIES; LEVEL; NM AB A four-level, plane wave model is proposed for a resonantly pumped 1.6 mu m Er3+ laser, including the effect of upconversion. A mean population approximation leads to analytical expressions for the threshold and slope efficiency that are highly accurate compared to the numerical solution. Using the beam area as an adjustable parameter, the threshold and slope efficiency agree well with data obtained using a 1% Er:YAG crystal, pumped at 1470 nm, lasing at 1617 nm, in the range 0-100 degrees C. According to the model for this laser, the slope efficiency versus absorbed pump power is unaffected by upconversion, but the threshold is increased by a factor of 2-3. The results are important for choosing the optimum doping level and fiber or rod length. (C) 2007 Optical Society of America. C1 Army Res Lab, Adelphi, MD 20783 USA. Princeton Lightwave Inc, Cranbury, NJ 08512 USA. RP White, JO (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jeffrry.owen.white@arl.army.mil NR 11 TC 25 Z9 25 U1 1 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD SEP PY 2007 VL 24 IS 9 BP 2454 EP 2460 DI 10.1364/JOSAB.24.002454 PG 7 WC Optics SC Optics GA 215XO UT WOS:000249842500058 ER PT J AU Batchinsky, AL Cancio, LC Salinas, J Kuusela, T Cooke, WH Wang, JJ Boehme, M Convertino, VA Holcomb, JB AF Batchinsky, Andriy I. Cancio, Leopoldo C. Salinas, Jose Kuusela, Tom Cooke, William H. Wang, Jing Jing Boehme, Marla Convertino, Victor A. Holcomb, John B. TI Prehospital loss of R-to-R interval complexity is associated with mortality in trauma patients SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 20th Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 16-20, 2007 CL Ft Meyers, FL SP Eastern Assoc Surg Trauma DE trauma; prehospital; mortality; electrocardiography; complexity; nonlinear analysis; spectrum analysis ID HEART-RATE-VARIABILITY; ACUTE MYOCARDIAL-INFARCTION; ATRIAL-FIBRILLATION; DYNAMICS; PHYSIOLOGY; PRESSURE; FRACTALS; CHAOS AB Background: To improve our ability to identify physiologic deterioration caused by critical injury, we applied nonlinear analysis to the R-to-R interval (RRI) of the electrocardiogram of prehospital trauma patients. Methods: Ectopy-free, 800-beat sections of electrocardiogram from 31 patients were identified. Twenty patients survived (S) and 11 died (NonS) after hospital admission. Demographic data, heart rate, blood pressure, field Glasgow Coma Scale (GCS) score, and survival times were recorded. RRI complexity was assessed via nonlinear statistics, which quantify entropy or fractal properties. Results: Age and field heart rate and blood pressure were not different between groups. Mean survival time (NonS) was 129 hours +/- 62 hours. NonS had a lower GCS score (8.6 +/- 1.7 vs. 13.2 +/- 0.8, p < 0.05). RRI approximate entropy (ApEn; 0.87 +/- 0.06 vs. 1.09 +/- 0.07, p < 0.01), sample entropy (SampEn; 0.80 +/- 0.08 vs. 1.10 +/- 0.05, p < 0.01) and fractal dimension by dispersion analysis (1.08 +/- 0.02 vs. 1.13 +/- 0.01, p < 0.05) were lower in NonS. Distribution of symbol 2 (Dis_2), a symbol-dynamics measure of RRI distribution, was higher in NonS (292.6 +/- 34.4 vs. 222 +/- 21.3, p < 0.10). For RRI data, logistic regression analysis revealed ApEn and Dis_2 as independent predictors of mortality (area under the receiver-operating characteristic curve = 0.96). When GCS(MOTOR) was considered, it replaced Dis_2 whereas ApEn was retained (area under curve = 0.92). When Injury Severity Score was considered, it replaced GCS(MOTOR); ApEn was retained. Conclusions: Prehospital loss of RRI complexity, as evidenced by decreased entropy, was associated with mortality in trauma patients independent of GCS score or Injury Severity Score. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Turku, SF-20500 Turku, Finland. Univ Texas, Dept Hlth & Kinesiol, Lab Autonom Neurophysiol, San Antonio, TX USA. RP Batchinsky, AL (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM andriy.batchinsky@amedd.army.mil NR 38 TC 38 Z9 38 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 2007 VL 63 IS 3 BP 512 EP 518 DI 10.1097/TA.0b013e318142d2f0 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 211DA UT WOS:000249503300006 PM 18073594 ER PT J AU Mahlon, MA Yoon, HC AF Mahlon, Michael A. Yoon, Hyo-Chun TI CT angiography of the superior vena cava: normative values and implications for central venous catheter position SO JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY LA English DT Article ID PLACEMENT; LANDMARK; ANATOMY; CARINA AB PURPOSE: To determine normative data for radiographic landmarks of the superior vena cava (SVC) and the location of the junction of the SVC with the right atrium for use in the placement of central venous catheters. MATERIALS AND METHODS: The authors retrospectively reviewed 112 pulmonary computed tomographic (CT) angiograms obtained in seven men and seven women from each decade of life between the ages of 20 and 99 years. For each patient, the length of the SVC was measured from its origin to the cavoatrial junction. The distances from the carina and right tracheobronchial angle to the cavoatrial junction and the origin of the SVC were also measured. Interobserver variation in choosing the location of the carina and tracheobronchial angle was analyzed. RESULTS: The mean length (+/- standard deviation) of the SVC was 70.7 mm +/- 14.1. The mean distance from the superior margin of the SVC to the carina was 30.4 mm +/- 11.2, from the carina to the cavoatrial junction 40.3 mm +/- 13.6, from the superior margin of the SVC to the right tracheobronchial angle 21.7 mm +/- 10.8, and from the right tracheobronchial angle to the cavoatrial junction 49.0 mm +/- 13.6. There was a statistically significant difference in interobserver variation in selecting the location of the right tracheobronchial angle as compared to choosing the carina. CONCLUSION: Placement of the central venous catheter tip at or just below the level of the carina during inspiration ensures placement in the SVC. Placement of the central venous catheter tip approximately 4 cm below the carina will result in placement near the cavoatrial junction. C1 Kaiser Fdn Hosp, Dept Diagnost Imaging, Honolulu, HI 96814 USA. Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Yoon, HC (reprint author), Kaiser Fdn Hosp, Dept Diagnost Imaging, 3288 Moanalua Rd, Honolulu, HI 96814 USA. EM Hyo-Chun.Yoon@kp.org NR 12 TC 19 Z9 20 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1051-0443 J9 J VASC INTERV RADIOL JI J. Vasc. Interv. Radiol. PD SEP PY 2007 VL 18 IS 9 BP 1106 EP 1110 DI 10.1016/j.jvir.2007.06.002 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging; Peripheral Vascular Disease SC Radiology, Nuclear Medicine & Medical Imaging; Cardiovascular System & Cardiology GA 211TX UT WOS:000249547300008 PM 17804772 ER PT J AU John, SP Wang, T Steffen, S Longhi, S Schmaljohn, CS Jonsson, CB AF John, Sinu P. Wang, Tan Steffen, Scott Longhi, Sonia Schmaljohn, Connie S. Jonsson, Colleen B. TI Ebola virus VP30 is an RNA binding protein SO JOURNAL OF VIROLOGY LA English DT Article ID RESPIRATORY SYNCYTIAL VIRUS; DOUBLE-STRANDED-RNA; MARBURG-VIRUS; SECONDARY STRUCTURE; ESCHERICHIA-COLI; TERMINAL DOMAIN; M2-1 PROTEIN; SEQUENCE; TRANSCRIPTION; PREDICTION AB The Ebola virus (EBOV) genome encodes for several proteins that are necessary and sufficient for replication and transcription of the viral RNAs in vitro; NP, VP30, VP35, and L. VP30 acts in trans with an RNA secondary structure upstream of the first transcriptional start site to modulate transcription. Using a bioinformatics approach, we identified a region within the N terminus of VP30 with sequence features that typify intrinsically disordered regions and a putative RNA binding site. To experimentally assess the ability of VP30 to directly interact with the viral RNA, we purified recombinant EBOV VP30 to > 90% homogeneity and assessed RNA binding by UV cross-linking and filter-binding assays. VP30 is a strongly acidophilic protein; RNA binding became stronger as pH was decreased. Zn2+, but not Mg2+, enhanced activity. Enhancement of transcription by VP30 requires a RNA stem-loop located within nucleotides 54 to 80 of the leader region. VP30 showed low binding affinity to the predicted stem-loop alone or to double-stranded RNA but showed a good binding affinity for the stem-loop when placed in the context of upstream and downstream sequences. To map the region responsible for interacting with RNA, we constructed, purified, and assayed a series of N-terminal deletion mutations of VP30 for RNA binding. The key amino acids supporting RNA binding activity map to residues 26 to 40, a region rich in arginine. Thus, we show for the first time the direct interaction of EBOV VP30 with RNA and the importance of the N-terminal region for binding RNA. C1 So Res Inst, Dept Biochem & Mol Biol, Birmingham, AL 35205 USA. Univ Alabama Birmingham, Grad Program Biochem & Mol Genet, Birmingham, AL 35294 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. CNRS, UMR 6098, F-13288 Marseille 09, France. Univ Aix Marseille 1, F-13288 Marseille 09, France. Univ Aix Marseille 2, F-13288 Marseille 09, France. RP Jonsson, CB (reprint author), So Res Inst, Dept Biochem & Mol Biol, 2000 9th Ave S, Birmingham, AL 35205 USA. EM jonsson@sri.org RI Longhi, Sonia/M-5305-2014 OI Longhi, Sonia/0000-0002-6829-6771 NR 46 TC 27 Z9 29 U1 2 U2 12 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD SEP PY 2007 VL 81 IS 17 BP 8967 EP 8976 DI 10.1128/JVI.02523-06 PG 10 WC Virology SC Virology GA 202SL UT WOS:000248923700010 PM 17567691 ER PT J AU Solomon, NP Ramanathan, P Makashay, MJ AF Solomon, Nancy Pearl Ramanathan, Pradeep Makashay, Matthew J. TI Phonation threshold pressure across the pitch range: Preliminary test of a model SO JOURNAL OF VOICE LA English DT Article; Proceedings Paper CT 34th Annual Symposium of the Voice-Foundation CY JUN, 2005 CL Philadelphia, PA DE phonation threshold pressure; normal phonation-pitch ID VOCAL WARM-UP; SUBGLOTTAL PRESSURE; SYSTEMIC HYDRATION; PHYSICAL MODEL; FATIGUING TASK; FOLD MUCOSA; VOICE; LOUDNESS; FREQUENCY; SINGERS AB This study sought to examine the specific relationship between phonation threshold pressure (PTP) and voice fundamental frequency (F-0) across the pitch range. A published theoretical model of this relationship described a quadratic equation, with PTP increasing exponentially with F-0. Prospective data from eight adults with normal, untrained voices were collected. Subjects produced their quietest phonation at 10 randomly ordered pitches from 5% to 95% of their semitone pitch range at 10% intervals. Analysis included curve fitting for individual and group data, as well as comparisons to the previous model. The group data fit a quadratic function similar to that proposed previously, but the specific quadratic coefficient and constant values differed. Four of the individual subjects' data were best fit by quartic functions, two by quadratic functions, and one by a linear function. This preliminary study indicates that PTP may be minimal at a "comfortable" pitch rather than the lowest pitch tested, and that, for some individuals, PTP may be slightly elevated during the passaggio between modal and falsetto vocal registers. These data support the general form of the theoretical PTP-F-0 function for these speakers, and indicate the possibility of potential refinements to the model. Future studies with larger groups of male and female subjects across a wider age range may eventually reveal the specific nature of the function. C1 Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. Univ Minnesota, Dept Speech & Language Sci, Minneapolis, MN USA. RP Solomon, NP (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM nancy.p.solomon@us.army.mil FU NIDCD NIH HHS [R03 DC06096] NR 30 TC 21 Z9 24 U1 1 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0892-1997 J9 J VOICE JI J. Voice PD SEP PY 2007 VL 21 IS 5 BP 541 EP 550 DI 10.1016/j.jvoice.2006.04.002 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA 209UI UT WOS:000249413100004 PM 16753281 ER PT J AU Nadim, F Bagtzoglou, AC Hoag, GE Ogden, FL Warner, GS Soballe, DM AF Nadim, Farhad Bagtzoglou, Amvrossios C. Hoag, George E. Ogden, Fred L. Warner, Glenn S. Soballe, David M. TI Application of a steady-state nutrient model and inferences for goad reduction strategy in two public water supply reservoirs in eastern Connecticut SO LAKE AND RESERVOIR MANAGEMENT LA English DT Article DE bathtub; eutrophication; lakes; nutrients; streams; water quality ID NITROGEN; DEPOSITION; MANAGEMENT; PHOSPHORUS; WET AB Mansfield Hollow Lake (MHL) and Willimantic Reservoir (WR) are two reservoir lakes located in eastern Connecticut in the northeastern United States. MHL formed behind the Mansfield Hollow Dam constructed by the U.S. Army Corps of Engineers in 1952 and is primarily fed by the Fenton, Mount Hope and Natchaug Rivers. The WR lies approximately 1-km downstream from the Mansfield Hollow Dam. Total dissolved nitrogen, phosphorus and chlorophyll a measurements indicate the water bodies could be classified as borderline mesotrophic/eutrophic. A steady-state numerical software package (Bathtub) designed to facilitate application of empirical eutrophication models to morphometrically complex reservoirs was used to determine the trophic status in MHL and WR based on different phosphorus and nitrogen loading budgets. The short hydraulic residence times and rapid flushing rates in MHL and WR are directly related to the flow rates in the streams discharging into MHL. The low flow period could significantly increase the hydraulic residence times of these two reservoirs. Therefore, the sampling design emphasized periods of low flow in late August and early September to assess the impact of nutrient inputs to MHL and WR during dry periods. The results of a low flow sampling period (August 2002) were used to calibrate and test the Bathtub model developed for these water bodies. Application of the Bathtub model to differing flow regimes, notably average flows, suggested that nitrogen or phosphorus could limit the productivity and cause eutrophication in the two lakes. Results of this study indicated that the Bathtub model could be used to predict total nitrogen and total phosphorus concentrations with reasonable accuracy, but it might not be a suitable tool for predicting organic nitrogen or algae in rapidly flushing lake systems. To further investigate and validate the assumptions made in this study, more sampling data are needed, especially during high intensity storm events to investigate possible sources of nutrient flow into the two lake system and further calibrate the Bathtub model for the MHL-WR watershed. C1 [Nadim, Farhad; Bagtzoglou, Amvrossios C.; Hoag, George E.] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. [Ogden, Fred L.] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82072 USA. [Warner, Glenn S.] Univ Connecticut, Dept Nat Resources Management & Engn, Storrs, CT 06269 USA. [Soballe, David M.] USA, Environm Lab, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Nadim, F (reprint author), Univ Connecticut, Dept Civil & Environm Engn, Unit 2037, Storrs, CT 06269 USA. RI Bagtzoglou, Amvrossios/C-4563-2011 NR 25 TC 0 Z9 0 U1 2 U2 10 PU NORTH AMER LAKE MANAGEMENT SOC PI MADISON PA PO BOX 5443, MADISON, WI 53705-5443 USA SN 1040-2381 J9 LAKE RESERV MANAGE JI Lake Reserv. Manag. PD SEP PY 2007 VL 23 IS 3 BP 264 EP 278 PG 15 WC Limnology; Marine & Freshwater Biology; Water Resources SC Marine & Freshwater Biology; Water Resources GA 333OP UT WOS:000258162100006 ER PT J AU Wang, G Gertner, G Anderson, AB Howard, H Gebhart, D Althoff, D Davis, T Woodford, P AF Wang, G. Gertner, G. Anderson, A. B. Howard, H. Gebhart, D. Althoff, D. Davis, T. Woodford, P. TI Spatial variability and temporal dynamics analysis of soil erosion due to military land use activities: Uncertainty and implications for land management SO LAND DEGRADATION & DEVELOPMENT LA English DT Article DE erosion; mapping; military land use; remote sensing; spatial simulation; uncertainty ID GEOSTATISTICAL METHODS; LOSS EQUATION; TM IMAGES; RUSLE; VARIABLES AB Human activities, such as military off-road vehicular traffic, disturb ground and vegetation cover of landscapes and increase potential rainfall related runoff and soil erosion. On military lands, soil erosion is of major concern in order to sustain training lands and thus there is a need for land condition maps for planning training activities and land management. In this study, we presented a conditional co-simulation algorithm to generate annual time series maps of soil erosion status from 1989 to 2001 for an army installation. The spatial variability and temporal dynamics of land condition were analyzed. This algorithm modeled soil erosion as realizations of a random function by combining a set of permanent plot data and Landsat Thematic Mapper (TM) images. In addition to estimation maps of soil erosion status, we obtained the maps of uncertainties including the variance of each pixel estimate and the probability of poor land condition. The results and maps are useful tools for land managers and decision-makers to guide military training programs and to generate management plans for sustaining training lands. Copyright (C) 2007 John Wiley & Sons, Ltd. C1 Univ Illinois, Urbana, IL 61801 USA. USA, Corps Engineers, CERL, Champaign, IL USA. Kansas State Univ, Manhattan, KS 66506 USA. USA, ATTN, AFZN GT RD, Ft Riley, KS USA. RP Gertner, G (reprint author), Univ Illinois, W503 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. EM gertner@uiuc.edu NR 27 TC 12 Z9 13 U1 0 U2 6 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1085-3278 J9 LAND DEGRAD DEV JI Land Degrad. Dev. PD SEP-OCT PY 2007 VL 18 IS 5 BP 519 EP 542 DI 10.1002/ldr.794 PG 24 WC Environmental Sciences; Soil Science SC Environmental Sciences & Ecology; Agriculture GA 226EW UT WOS:000250571400004 ER PT J AU Muza, SR AF Muza, Stephen R. TI Military applications of hypoxic training for high-altitude operations SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE altitude acclimatization; acute mountain sickness; intermittent; hypoxia; military operations ID ACUTE MOUNTAIN-SICKNESS; INTERMITTENT HYPOBARIC HYPOXIA; SIMULATED ALTITUDE; VENTILATORY RESPONSE; SEA-LEVEL; EXERCISE PERFORMANCE; NORMOBARIC HYPOXIA; LIVING LOW; HUMANS; EXPOSURE AB Rapid deployment of unacclimatized soldiers to high mountainous environments causes debilitating effects on operational capabilities (physical work performance), and force health (altitude sickness). Most of these altitude-induced debilitations can be prevented or ameliorated by a wide range of physiological responses collectively referred to as altitude acclimatization. Acclimatization to a target altitude can be induced by slow progressive ascents or continuous sojourns at intermediate altitudes. However, this "altitude residency" requirement reduces their utilization in rapid response military missions that exploit the air mobility capability of modem military forces to quickly deploy to an area of operations on short notice. A more recent approach to induce altitude acclimatization is the use of daily intermittent hypoxic exposures (IHE) in lieu of continuous residence at high altitudes. IHE treatments consist of three elements: 1) IHE simulated altitude (inspired oxygen partial pressure: PIO2), 2) IHE session duration, and 3) total number of IHE sessions over the treatment period. This paper reviews and summarizes the results of 25 published IHE studies. This review finds that an IHE altitude >= 4000 m, and daily exposure duration of at least 1.5 h repeated over a week or more are required to have a high probability of developing altitude acclimatization. The efficacy of shorter duration (< 1.5 h) hypoxic exposures at >= 4000 m simulated altitudes, and longer exposures (> 4 h) at moderate altitudes (2500-3500 m) is not well documented. The predominate IHE-induced altitude acclimatization response appears to be increased arterial oxygen content through ventilatory acclimatization. Thus, IHE is a promising approach to provide the benefits of altitude acclimatization to low-altitude-based soldiers before their deployment to high mountainous regions. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Muza, SR (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 02053 USA. EM stephen.muza@us.army.mil NR 43 TC 32 Z9 34 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD SEP PY 2007 VL 39 IS 9 BP 1625 EP 1631 DI 10.1249/mss.0b013e3180de49fe PG 7 WC Sport Sciences SC Sport Sciences GA 210GW UT WOS:000249445700025 PM 17805096 ER PT J AU Kageleiry, MP AF Kageleiry, Major Peter, Jr. TI Psychological police interrogation methods: Pseudoscience in the interrogation room obscures justice in the courtroom SO MILITARY LAW REVIEW LA English DT Article ID PREVENTING WRONGFUL CONVICTIONS; FALSE CONFESSIONS; DECEPTION; JUDGMENTS; INNOCENT; MIRANDA; GUILTY; TRUTH C1 21st Theater Sustainment Command, Kaiserslautern, Germany. USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Kageleiry, MP (reprint author), 21st Theater Sustainment Command, Kaiserslautern, Germany. NR 61 TC 1 Z9 1 U1 1 U2 6 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2007 VL 193 BP 1 EP 51 PG 51 WC Law SC Government & Law GA 256IG UT WOS:000252721300001 ER PT J AU Levine, MJD AF Levine, Major James D., II TI The doctrine of command responsibility and its application to superior civilian leadership: Does the international criminal court have the correct standard? SO MILITARY LAW REVIEW LA English DT Article ID WAR-CRIMES; LAW C1 [Levine, Major James D., II] USA, Charlottesville, VA 22901 USA. RP Levine, MJD (reprint author), 3d Infantry Div, Brigade Combat Team 2d, Ft Stewart, GA USA. NR 46 TC 1 Z9 1 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2007 VL 193 BP 52 EP 96 PG 45 WC Law SC Government & Law GA 256IG UT WOS:000252721300002 ER PT J AU Barkei, MJA AF Barkei, Major James A. TI Legislating military doctrine: Congressional usurping of Executive authority through detainee interrogations SO MILITARY LAW REVIEW LA English DT Article ID WAR; FORCES; POWER C1 USA, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA 22901 USA. RP Barkei, MJA (reprint author), USA, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA 22901 USA. NR 63 TC 0 Z9 0 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2007 VL 193 BP 97 EP 143 PG 47 WC Law SC Government & Law GA 256IG UT WOS:000252721300003 ER PT J AU Warner, CH Breitbach, JE Appenzeller, GN Yates, V Grieger, T Webster, WG AF Warner, Christopher H. Breitbach, Jill E. Appenzeller, George N. Yates, Virginia Grieger, Thomas Webster, William G. TI Division mental health in the new brigade combat team structure: Part I. Predeployment and deployment SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT United States Army Force Health Protection Conference CY AUG 07-11, 2006 CL Albuquerque, NM AB Objective: Recent Army transformation has led to significant changes in roles and demands for division mental health (DMH) staff members. This article focuses on predeployment and deployment. Methods: Surveillance of Combat and Operational Stress Reactions data, review of DMH implementation plans, and observations by staff members, providers, and soldiers were reviewed. Results: During the course of the deployment, the Task Force Baghdad DMH unit had > 22,000 soldier encounters with 5,542 clinical encounters. The duration of the deployment and increased levels of threat later in the deployment resulted in increased stress problems but not a substantial or sustained increase in mental health casualties. Conclusions: Predeployment education and communication probably eliminated some problems during deployment, and communication among mental health and command units during deployment resolved most problems encountered. C1 Infantry Div 3rd, Ft Stewart, GA 31314 USA. Special warfare Training Grp 1st, Ft Bragg, NC 28307 USA. Martin Army Community Hosp, Dept Family Practice, Ft Benning, GA 31905 USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. RP Warner, CH (reprint author), Infantry Div 3rd, Ft Stewart, GA 31314 USA. NR 7 TC 14 Z9 14 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2007 VL 172 IS 9 BP 907 EP 911 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 210HT UT WOS:000249448000002 PM 17937351 ER PT J AU Warner, CH Breitbach, JE Appenzeller, GN Yates, V Grieger, T Webster, WG AF Warner, Christopher H. Breitbach, Jill E. Appenzeller, George N. Yates, Virginia Grieger, Thomas Webster, William G. TI Division mental health in the new brigade combat team structure: Part II. Redeployment and postdeployment SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT United States Army Force Health Protection Conference CY AUG 07-11, 2006 CL Albuquerque, NM ID DEPRESSION; AFGHANISTAN; MILITARY; VALIDITY; IRAQ AB Objective: Recent Army transformation has led to significant changes in roles and demands for division mental health staff members. This article focuses on redeployment and postdeployment. Methods: The postdeployment health assessment behavioral health screening and referral process and redeployment plan are reviewed, and data on postdeployment rates of negative events are reported. Results: All soldiers and many of their families participated in an aggressive education program. Of the 19,500 soldiers screened, 2,170 (11.1%) were referred for behavioral health consultation; of those referred, 219 (10.1%) were found to be at moderate or high risk for mental health issues (1.1% of total screened). Of the moderate/high-risk soldiers, 146 (71.9%) accepted follow-up mental health treatment upon return to home station. Fewer cases of driving under the influence, positive drug screens, suicidal gestures/ attempts, crimes, and acts of domestic violence were seen, in comparison with rates seen after an earlier deployment of this unit to Iraq. Conclusions: A formalized approach with command support and coordination can have a positive impact on successful referral and treatment and reduce negative postdeployment events. C1 Infantry Div 3rd, Ft Stewart, GA 31314 USA. Special Warfare Training Grp 1st, Ft Bragg, NC 28307 USA. Martin Army Community Hosp, Dept Family Practice, Ft Benning, GA 31905 USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. RP Warner, CH (reprint author), Infantry Div 3rd, Ft Stewart, GA 31314 USA. NR 13 TC 13 Z9 13 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2007 VL 172 IS 9 BP 912 EP 917 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 210HT UT WOS:000249448000003 PM 17937352 ER PT J AU Waasdorp, CE Caboot, JB Robinson, CA Abraham, AA Adelman, WP AF Waasdorp, Christine E. Caboot, Jason B. Robinson, C. Anita Abraham, Anisha A. Adelman, William P. TI Screening military dependent adolescent females for disordered eating SO MILITARY MEDICINE LA English DT Article ID ATTITUDES TEST; CONTRIBUTING FACTORS; ANOREXIA-NERVOSA; BULIMIA-NERVOSA; WEIGHT-LOSS; BEHAVIORS; POPULATION; PREVALENCE; SYMPTOMS; NAVY AB Eating disorders are increasing in frequency among adolescents. The active duty military population has a high prevalence of eating disorders. This study, conducted at a major medical center, determined the prevalence of disordered eating among military dependents and the correlation between adolescent and parent eating behaviors. Three hundred forty adolescent and parent pairs completed the Eating Attitude Test-26 question-based survey. Twenty-one percent of the adolescents and 26% of the parents met the criteria for disordered eating, with a strong correlation between at-risk parents and their adolescent daughters. Overall, the rate of disordered eating in this military sample was significantly higher than the comparable civilian population. Military families should be considered at high risk for disordered eating and eating disorders. Screening for disordered eating should be incorporated into routine practice to identify at-risk individuals. C1 Natl Naval Med Ctr, Dept Adolescent Med, Bethesda, MD 20889 USA. Winn Army Community Hosp, Serv Pediat, Ft Stewart, GA 31314 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. RP Waasdorp, CE (reprint author), Georgetown Univ Hosp, Dept Pediat, Sect Adolescent Med, 3800 Reservoir Rd, Washington, DC 20007 USA. NR 41 TC 7 Z9 8 U1 7 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2007 VL 172 IS 9 BP 962 EP 967 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 210HT UT WOS:000249448000011 PM 17937360 ER PT J AU Knapik, JJ Jones, SB Darakjy, S Hauret, KG Bullock, SH Sharp, MA Jones, BH AF Knapik, Joseph J. Jones, Sarah B. Darakjy, Salima Hauret, Keith G. Bullock, Steven H. Sharp, Marilyn A. Jones, Bruce H. TI Injury rates and injury risk factors among US army wheel vehicle mechanics SO MILITARY MEDICINE LA English DT Article ID UNITED-STATES; SOFTBALL INJURIES; RUNNING INJURIES; ANKLE INJURIES; FOLLOW-UP; PREVENTION; MORTALITY; EXERCISE; FITNESS; TRENDS AB This study describes injury rates, injury diagnoses, anatomical locations of injuries, limited duty days, and activities associated with injuries in a sample of Army mechanics. Medical records of 518 male and 43 female Army mechanics were screened for injuries during 1 year at a large U.S. Army installation. Weight, height, age, and ethnicity were also extracted from the medical records. Body mass index was calculated as weight/height(2). Overall injury rates for men and women were 124 and 156 injuries/100 person-years, respectively, with a rate of 127 injuries/100 person-years for all soldiers combined. Women had higher overuse injury rates while men had higher traumatic injury rates. Limited duty days for men and women were 2,076 and 1,966 days/100 person-years, respectively. The lower back, knee, ankle, foot, and shoulder involved 61% of the injuries. Activities associated with injury included (in order of incidence) physical training, mechanical work, sports, airborne-related activities, road marching, garrison/home activities, and chronic conditions. Among the men, elevated injury risk was associated with higher body weight and higher body mass index. It may be possible to prevent many injuries by implementation of evidenced-based interventions currently available in the literature. C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Knapik, JJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, 1570 Stark Rd, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@us.army.mil NR 51 TC 26 Z9 28 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2007 VL 172 IS 9 BP 988 EP 996 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 210HT UT WOS:000249448000016 PM 17937365 ER PT J AU Arnett, MV Lim, JT AF Arnett, Michael V. Lim, Julia T. TI Ciguatera fish poisoning: Impact for the military health care provider SO MILITARY MEDICINE LA English DT Article ID COMMON-SOURCE OUTBREAK; MANNITOL AB Ciguatera toxin is a marine neurotoxin produced by microorganisms that becomes concentrated in predatory fish. Toxicity in humans results from the ingestion of contaminated fish harvested in tropical waters. Clinical manifestations of illness include the rapid onset of gastrointestinal symptoms and neurological abnormalities. Because of the rapid onset of symptoms and the potential for case clusters from a common source ingestion of contaminated fish, there is the potential that ciguatera poisoning may initially mimic illnesses caused by antipersonnel biological and chemical agents. We present data on an active duty soldier who presented to sick call for evaluation of new onset paresthesias and was diagnosed with ciguatera toxin poisoning. We also present a review of ciguatera poisoning literature with emphasis on the distinguishing features between ciguatoxin and other neurotoxins of military significance. C1 Tripler Army Med Ctr, Dept Med, MCHK DM, Honolulu, HI 96859 USA. RP Arnett, MV (reprint author), Tripler Army Med Ctr, Dept Med, MCHK DM, 1 jarret White Rd, Honolulu, HI 96859 USA. NR 20 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2007 VL 172 IS 9 BP 1012 EP 1015 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 210HT UT WOS:000249448000020 PM 17937369 ER PT J AU Brave, A Boberg, A Gudmundsdotter, L Rollman, E Hallermalm, K Ljungberg, K Blomberg, P Stout, R Paulie, S Sandstrom, E Biberfeld, G Earl, P Moss, B Cox, JH Wahren, B AF Brave, Andreas Boberg, Andreas Gudmundsdotter, Lindvi Rollman, Erik Hallermalm, Kristian Ljungberg, Karl Blomberg, Pontus Stout, Richard Paulie, Staffan Sandstrom, Eric Biberfeld, Gunnel Earl, Patricia Moss, Bernard Cox, Josephine H. Wahren, Britta TI A new multi-clade DNA prime/recombinant MVA boost vaccine induces broad and high levels of HIV-1-specific CD8(+) T-cell and humoral responses in mice SO MOLECULAR THERAPY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-RESPONSES; HIV-1 VACCINE; ANTIBODY-RESPONSES; GENE-TRANSFER; PLASMID DNA; GAG REGION; IMMUNOGENICITY; AIDS; IMMUNIZATION AB The results presented here are from the preclinical evaluation in BALB/c mice of a DNA prime/modified vaccinia virus Ankara ( MVA) boost multi-gene multi-subtype human immunodeficiency virus-1(HIV-1) vaccine intended for use in humans. The plasmid DNA vaccine was delivered intradermally using a Biojector, and the MVA was delivered intramuscularly by needle. This combination of recombinant DNA and MVA proved to induce extraordinarily strong cellular responses, with more than 80% of the CD8(+) T cells specific for HIV-1 antigens. Furthermore, we show that the DNA priming increases the number of T-cell epitopes recognized after the MVA boost. In the prime/boost-immunized animals, a significant proportion of CD8+ T cells were stained positive for both interferon-gamma(IFN-gamma)and interleukin- 2 ( IL-2), a feature that has been associated with control of HIV-1 infection in long-term nonprogressors. The HIV-1-specific antibody levels were moderate after the plasmid DNA immunizations but increased dramatically after the MVA boost. Although the initial injection of MVA induced significant levels of vaccinianeutralizing antibodies, the HIV-specific responses were still significantly boosted by the second MVA immunization. The results from this study demonstrate the potency of this combination of DNA plasmids and MVA construct to induce broad and high levels of immune responses against several HIV-1 proteins of different subtypes. C1 Swedish Inst Infect Dis Control, Dept Virol, S-17182 Solna, Sweden. Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia. Univ N Carolina, Carolina Vaccine Inst, Chapel Hill, NC USA. Karolinska Univ Hosp, Huddinge, Sweden. Bioject Med Technol, Tualatin, OR USA. Mabtech AB, Nacka, Sweden. Dept Clin Sci & Educ, Stockholm, Sweden. NIAID, NIH, Viral Dis Lab, Bethesda, MD 20892 USA. Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. RP Brave, A (reprint author), Swedish Inst Infect Dis Control, Dept Virol, S-17182 Solna, Sweden. EM andreas.brave@smi.ki.se OI Ljungberg, Karl/0000-0001-7192-6204 NR 42 TC 30 Z9 30 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 1525-0016 J9 MOL THER JI Mol. Ther. PD SEP PY 2007 VL 15 IS 9 BP 1724 EP 1733 DI 10.1038/sj.mt.6300235 PG 10 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 205LW UT WOS:000249116400026 PM 17579577 ER PT J AU Heaton, KJ Palumbo, CL Proctor, SP Killiany, RJ Yurgelun-Todd, DA White, RF AF Heaton, Kristin J. Palumbo, Carole L. Proctor, Susan P. Killiany, Ronald J. Yurgelun-Todd, Deborah A. White, Roberta F. TI Response to "Latency: An important consideration in Gulf War Syndrome," by Friedman et al. [Neurotoxicology (in press)] SO NEUROTOXICOLOGY LA English DT Letter DE gulf war; brain; sarin; cyclosarin; Gulf War Syndrome; gulf war veterans illnesses ID US ARMY VETERANS; CYCLOSARIN; SARIN C1 US Army Res Inst Environm Med, Natick, MA 01760 USA. Boston Univ, Sch Med, Dept Neurol, Boston, MA USA. Boston Univ, Sch Med, Dept Neurol, Dept Neurobiol & Anat, Boston, MA USA. McLean Hosp, Cognit Neuroimaging, Neuropsychol Brain Imaging Ctr, Belmont, MA USA. Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. RP Heaton, KJ (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA. EM kristin.heaton@us.army.mil RI Heaton, Kristin/E-3660-2013 NR 3 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD SEP PY 2007 VL 28 IS 5 BP 1044 EP 1045 DI 10.1016/j.neuro.2007.07.009 PG 2 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 230VU UT WOS:000250905100018 ER PT J AU Myers, T LaMont, J Kahler, D Lumley, L AF Myers, T. M. LaMont, J. C. Kahler, D. W. Lumley, L. A. TI Effects of repeated sublethal VX exposure on operant time estimation in rats SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Meeting Abstract CT 31st Annual Meeting of the Neurobehavioral-Teratology-Society/26th Annual Meeting of the Behavioral-Toxicology-Society held in Conjunction with the 47th Annual Meeting of the Teratology-Society/20th Organization-of-Teratology-Information-Specialists CY JUN 23-27, 2007 CL Pittsburgh, PA SP Neurobehav Teratol Soc, Behav Toxicol Soc, Teratol Soc, Org Teratol Informat Specialists C1 US Army Med Res, Inst Chem Defense, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD SEP-OCT PY 2007 VL 29 IS 5 BP 589 EP 590 DI 10.1016/j.ntt.2007.08.024 PG 2 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA 237EM UT WOS:000251356600013 ER PT J AU DeMartelaere, SL Perman, KI Shore, JW AF DeMartelaere, Sheri L. Perman, Kevin I. Shore, John W. TI Orbital septal resection and the hanging curtain of fat SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article; Proceedings Paper CT 37th Annual Scientific Symposium of the American-Society-of-Ophthalmic-Plastic-and-Reconstructive-Surgeons CY NOV, 2006 CL Las Vegas, NV ID LOWER-EYELID BLEPHAROPLASTY; MIDFACE REJUVENATION; COMPOSITE RHYTIDECTOMY; COMPLICATIONS; PRESERVATION; SURGERY AB Purpose: To describe a technique of lower eyelid blepharoplasty and report observations on 274 consecutive surgeries. Methods: Retrospective, noncomparative case series of lower eyelid blepharoplasty by 2 surgeons from January 2004 through January 2006. Results: Two-hundred seventy-four eyelids of 137 patients underwent transcutaneous lower eyelid blepharoplasty for the treatment of steatoblepharon. There were 27 men and I 10 women with an age range of 35 years to 85 years. Minimum length of follow-up was 6 months. Two-thirds of patients had simultaneous horizontal lower eyelid tightening. Four patients (3%) had surgical enhancement for retained lower eyelid fat. Conclusions: With appropriate patient selection, orbital septal excision is an effective aesthetic technique for lower eyelid blepharoplasty. It combines surgical simplicity with good cosmetic outcomes. C1 Texas Oculoplast Consultants, Austin, TX 78705 USA. Brooke Army Med Ctr, Ophthalmol Serv, Houston, TX USA. Ctr Eyelid & Facial Plast Surg, Bethesda, MD USA. RP Shore, JW (reprint author), Texas Oculoplast Consultants, Austin Med Plaza,3705 Med Pkwy,Suite 120, Austin, TX 78705 USA. EM jshore@tocaustin.com NR 21 TC 5 Z9 5 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0740-9303 J9 OPHTHAL PLAST RECONS JI Ophthalmic Plast. Reconstr. Surg. PD SEP-OCT PY 2007 VL 23 IS 5 BP 349 EP 354 DI 10.1097/IOP.0b013e318142d305 PG 6 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 215MI UT WOS:000249812300002 PM 17881982 ER PT J AU Petney, TN Kolonin, GV Robbins, RG AF Petney, Trevor N. Kolonin, Gennady V. Robbins, Richard G. TI Southeast Asian ticks (Acari : Ixodida): a historical perspective SO PARASITOLOGY RESEARCH LA English DT Article; Proceedings Paper CT Asian Ticks Conference CY APR, 2006 CL Istanbul, TURKEY SP Integrated Consortium Ticks Tick Borne Dis 3 (ICTTD-3) ID INDOCENTOR TAIWANENSIS ACARI; THEILERIA PARASITES; IXODOIDEA-IXODIDAE; MOLECULAR EVIDENCE; MALAY PENINSULA; GENE-SEQUENCES; RIBOSOMAL DNA; AURATUS ACARI; FEMALE; HOSTS AB Our knowledge of the species of ticks present in Southeast Asia is good, particularly due to the vast amount of work from the 1960s to the 1980s by Hoogstraal and colleagues. Unfortunately, this knowledge is scattered throughout the specialist literature, and there is currently no synopsis available. In addition, our knowledge of the tick fauna of several countries, for example Cambodia, Laos, and Myanmar, is very limited. C1 Inst Zool 1, Abt Okol Parasitol, D-76131 Karlsruhe, Germany. Management Russian Fed, Fed Serv Supervis Nat Resources, Moscow 123195, Russia. Walter Reed Army Med Ctr, Armed Forces Pest Management Board, Washington, DC 20307 USA. RP Petney, TN (reprint author), Inst Zool 1, Abt Okol Parasitol, Kornblumenstr 13, D-76131 Karlsruhe, Germany. EM trevor.petney@t-online.de NR 63 TC 6 Z9 9 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0932-0113 J9 PARASITOL RES JI Parasitol. Res. PD SEP PY 2007 VL 101 SU 2 BP S201 EP S205 DI 10.1007/s00436-007-0687-4 PG 5 WC Parasitology SC Parasitology GA 214EP UT WOS:000249719100012 PM 17823829 ER PT J AU Davis, JD Engel, CC Mishkind, M Jaffer, A Sjoberg, T Tinker, T McGough, M Tipton, S Armstrong, D O'Leary, T AF Davis, Jamie D. Engel, Charles C. Mishkind, Matthew Jaffer, Ambereen Sjoberg, Terry Tinker, Tim McGough, Martin Tipton, Stacia Armstrong, David O'Leary, Timothy TI Provider and patient perspectives regarding health care for war-related health concerns SO PATIENT EDUCATION AND COUNSELING LA English DT Article DE communication; provider-patient trust; post-deployment health concerns ID MILITARY MEDICINE; INTERNAL-MEDICINE; GULF-WAR; SATISFACTION; PHYSICIAN; OUTCOMES; CONTINUITY; QUALITY; COMMUNICATION; PERSONNEL AB Objective: To gain insight about Department of Defense providers' and health care beneficiaries' opinions regarding provider-patient communication of health care for post-deployment health concerns. Methods: Thirty-five Department of Defense primary care providers and 14 military beneficiaries participated in focus groups at five military medical treatment facilities. We audiotaped, transcribed, and qualitatively analyzed semi-structured focus group interviews to determine attitudes and beliefs about war-related health concerns, symptoms, and health care quality. Results: Focus groups revealed important insights about provider and patient perspectives of communication and care in four general areas: physician-patient trust, validity of symptoms and concerns, exchange of health information, and barriers to care. Conclusion: Provider-patient communication contributes to patient satisfaction with medical care; poor communication may contribute to decreased patient satisfaction and provider effectiveness. The military health care system poses several challenges to provider-patient communication: the dual nature of the provider's role, the occupational relationship between illness and health care, pre- and post-deployment issues, and continuity of care impact patient and provider perspectives. The prevalence of various beneficiary and provider concerns regarding health care communication requires further study, particularly for the severely wounded. Practice implications: The quality of information exchanged and of the interpersonal relationship impact medical decision making, particularly in occupational health settings such as the military. Attention to these issues may improve patient outcomes including satisfaction, adherence, trust, health status, and quality of life. (c) 2007 Elsevier Ireland Ltd. All rights reserved. C1 Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. Widmeyer Commun, Washington, DC USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Corp Execut Board, Washington, DC USA. RP Engel, CC (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM cengel@usuhs.mil NR 41 TC 4 Z9 4 U1 3 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0738-3991 J9 PATIENT EDUC COUNS JI Patient Educ. Couns. PD SEP PY 2007 VL 68 IS 1 BP 52 EP 60 DI 10.1016/j.pec.2007.04.007 PG 9 WC Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary SC Public, Environmental & Occupational Health; Social Sciences - Other Topics GA 206MW UT WOS:000249188600009 PM 17537612 ER PT J AU Sagripanti, JL Lytle, CD AF Sagripanti, Jose-Luis Lytle, C. David TI Inactivation of influenza virus by solar radiation SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Article ID SURVIVAL; HUMIDITY AB Influenza virus is readily transmitted by aerosols and its inactivation in the environment could play a role in limiting the spread of influenza epidemics. Ultraviolet radiation in sunlight is the primary virucidal agent in the environment but the time that influenza virus remains infectious outside its infected host remains to be established. In this study, we calculated the expected inactivation of influenza A virus by solar ultraviolet radiation in several cities of the world during different times of the year. The inactivation rates reported here indicate that influenza A virions should remain infectious after release from the host for several days during the winter "flu season" in many temperate-zone cities, with continued risk for reaerosolization and human infection. The correlation between low and high solar virucidal radiation and high and low disease prevalence, respectively, suggest that inactivation of viruses in the environment by solar UV radiation plays a role in the seasonal occurrence of influenza pandemics. C1 USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Sagripanti, JL (reprint author), USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. EM joseluis.sagripanti@us.army.mil NR 29 TC 37 Z9 41 U1 1 U2 8 PU AMER SOC PHOTOBIOLOGY PI AUGUSTA PA BIOTECH PARK, 1021 15TH ST, SUITE 9, AUGUSTA, GA 30901-3158 USA SN 0031-8655 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD SEP-OCT PY 2007 VL 83 IS 5 BP 1278 EP 1282 DI 10.1111/j.1751-1097.2007.00177.x PG 5 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 216MF UT WOS:000249881400034 PM 17880524 ER PT J AU Roppo, V Centini, M Sibilia, C Bertolotti, M de Ceglia, D Scalora, M Akozbek, N Bloemer, MJ Haus, JW Kosareva, OG Kandidov, VP AF Roppo, Vito Centini, Marco Sibilia, Concita Bertolotti, Mario de Ceglia, Domenico Scalora, Michael Akozbek, Neset Bloemer, Mark J. Haus, Joseph W. Kosareva, Olga G. Kandidov, Valery P. TI Role of phase matching in pulsed second-harmonic generation: Walk-off and phase-locked twin pulses in negative-index media SO PHYSICAL REVIEW A LA English DT Article ID LEFT-HANDED METAMATERIALS; PARAMETRIC AMPLIFICATION; HARMONIC-GENERATION; FEMTOSECOND PULSES; OPTICAL HARMONICS; LIGHT WAVES; PROPAGATION; PERMITTIVITY; PERMEABILITY; DISPERSION AB The present investigation is concerned with the study of pulsed second-harmonic generation under conditions of phase and group velocity mismatch, and generally low conversion efficiencies and pump intensities. In positive-index, nonmetallic materials, we generally find qualitative agreement with previous reports regarding the presence of a double-peaked second harmonic signal, which comprises a pulse that walks off and propagates at the nominal group velocity one expects at the second-harmonic frequency, and a second pulse that is "captured" and propagates under the pump pulse. We find that the origin of the double-peaked structure resides in a phase-locking mechanism that characterizes not only second-harmonic generation, but also chi((3)) processes and third-harmonic generation. The phase-locking mechanism that we describe occurs for arbitrarily small pump intensities, and so it is not a soliton effect, which usually relies on a threshold mechanism, although multicolor solitons display similar phase locking characteristics. Thus, in second harmonic generation a phase-matched component is always generated, even under conditions of material phase mismatch: This component is anomalous, because the material does not allow energy exchange between the pump and the second-harmonic beam. On the other hand, if the material is phase matched, phase locking and phase matching are indistinguishable, and the conversion process becomes efficient. We also report a similar phase-locking phenomenon in negative index materials. A spectral analysis of the pump and the generated signals reveals that the phase-locking phenomenon causes the forward moving, phase-locked second-harmonic pulse to experience the same negative index as the pump pulse, even though the index of refraction at the second-harmonic frequency is positive. Our analysis further shows that the reflected second-harmonic pulse generated at the interface and the forward-moving, phase-locked pulse appear to be part of the same pulse initially generated at the surface, part of which is immediately back-reflected, while the rest becomes trapped and dragged along by the pump pulse. These pulses thus constitute twin pulses generated at the interface, having the same negative wave vector, but propagating in opposite directions. Almost any break of the longitudinal symmetry, even an exceedingly small chi((2)) discontinuity, releases the trapped pulse which then propagates in the backward direction. These dynamics are indicative of very rich and intricate interactions that characterize ultrashort pulse propagation phenomena. C1 Univ Roma La Sapienza, Dipartimento Energet, Rome, Italy. US Army Aviat & Missile Command, Charles M Bowden Res Facil, RDECOM, Redstone Arsenal, AL 35803 USA. Univ Dayton, Electroopt Program, Dayton, OH 45469 USA. Moscow MV Lomonosov State Univ, Ctr Int Laser, Dept Phys, Moscow 119992, Russia. RP Roppo, V (reprint author), Univ Roma La Sapienza, Dipartimento Energet, Via Scarpa 16, Rome, Italy. RI roppo, vito/D-9639-2012; OI roppo, vito/0000-0003-0928-4209; CENTINI, MARCO/0000-0003-0625-0054 NR 66 TC 51 Z9 52 U1 0 U2 8 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD SEP PY 2007 VL 76 IS 3 AR 033829 DI 10.1103/PhysRevA.76.033829 PG 12 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 215CN UT WOS:000249786000170 ER PT J AU Currier, LL Froehlich, PJ Carow, SD McAndrew, RK Cliborne, AV Boyles, RE Mansfield, LT Wainner, RS AF Currier, Linda L. Froehlich, Paul J. Carow, Scott D. McAndrew, Ronald K. Cliborne, Amy V. Boyles, Robert E. Mansfield, Liem T. Wainner, Robert S. TI Development of a clinical prediction rule to identify patients with knee pain and clinical evidence of knee osteoarthritis who demonstrate a favorable short-term response to hip mobilization SO PHYSICAL THERAPY LA English DT Article ID LOW-BACK-PAIN; MANUAL THERAPY; SPINAL MANIPULATION; PRACTICE GUIDELINES; LIKELIHOOD RATIOS; PHYSICAL-THERAPY; CONTROLLED-TRIAL; DIAGNOSTIC-TEST; HEALTH-STATUS; EXERCISE AB Background and Purpose The primary purpose of this study was to develop a clinical prediction rule (CPR) for identifying patients with knee pain and clinical evidence of knee osteoarthritis (OA) with favorable short-term response to hip mobilizations. The secondary purpose was to determine the predictive validity of individual clinical tests for identifying these same patients. Subjects and Methods Sixty subjects with knee OA, aged 51 to 79 years, completed self-report questionnaires, a clinical examination of the hip and knee, and functional tests and were treated with 4 hip mobilizations. Follow-up, testing was completed 2 days later. The reference criterion for determining a favorable response was either (1) a decrease of at least 30% on composite Numerical Pain Rating Scale score obtained during functional tests or (2) a Global Rating of Change Scale score of at least 3. Results The CPR developed in this study comprised 5 variables: (1) hip or groin pain or paresthesia, (2) anterior thigh pain, (3) passive knee flexion less than 122 degrees, (4) passive hip medial (internal) rotation less than 17 degrees, and (5) pain with hip distraction. Based on the pretest probability of success (68%), the presence of one variable had a positive likelihood ratio of 5.1 and increased the probability of a successful response to 92% at 48-hour follow-up. If 2 variables were present, the Positive likelihood ratio was 12.9 and the probability of success increased to 97%. Discussion and Conclusion The results suggest that the CPR developed in this study could improve clinicians' decision making and efficiency in examining and treating patients with knee OA. C1 USA, Baylor Doctoral Program, Ft Sam Houston, TX 78234 USA. Womack Army Med Ctr, Ft Bragg, NC USA. Guthrie Med Dept, Ft Drum, NY USA. Bayne Jones Army Commun Hosp, Ft Polk, LA USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Currier, LL (reprint author), USA, Baylor Doctoral Program, Ft Sam Houston, TX 78234 USA. NR 50 TC 31 Z9 33 U1 0 U2 5 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD SEP PY 2007 VL 87 IS 9 BP 1106 EP 1117 DI 10.2522/ptj.20060066 PG 12 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 207RZ UT WOS:000249270100001 PM 17609333 ER PT J AU Murphey, MD Vidal, JA Fanburg-Smith, JC Gajewski, DA AF Murphey, Mark D. Vidal, Jorge A. Fanburg-Smith, Julie C. Gajewski, Donald A. TI From the archives of the AFIP - Imaging of synovial chondromatosis with radiologic-pathologic correlation SO RADIOGRAPHICS LA English DT Article ID TENOSYNOVIAL CHONDROMATOSIS; MALIGNANT-TRANSFORMATION; CHONDROSARCOMA SECONDARY; TEMPOROMANDIBULAR-JOINT; ULTRASOUND DIAGNOSIS; MR FINDINGS; BONE-SCAN; OSTEOCHONDROMATOSIS; HIP; SHOULDER AB Primary synovial chondromatosis represents an uncommon benign neoplastic process with hyaline cartilage nodules in the subsynovial tissue of a joint, tendon sheath, or bursa. The nodules may enlarge and detach from the synovium. The knee, followed by the hip, in male adults are the most commonly involved sites and patient population. The pathologic appearance may simulate chondrosarcoma because of significant histologic atypia, and radiologic correlation to localize the process as synovially based is vital for correct diagnosis. Radiologic findings are frequently pathognomonic. Radiographs reveal multiple intraarticular calcifications ( 70% - 95% of cases) of similar size and shape, distributed throughout the joint, with typical "ring-and-arc" chondroid mineralization. Extrinsic erosion of bone is seen in 20% - 50% of cases. Computed tomography ( CT) optimally depicts the calcified intraarticular fragments and extrinsic bone erosion. Magnetic resonance ( MR) imaging findings are more variable, depending on the degree of mineralization, although the most common pattern ( 77% of cases) reveals low to intermediate signal intensity with T1- weighting and very high signal intensity with T2weighting with hypointense calcifications. These signal intensity characteristics on MR images and low attenuation of the nonmineralized regions on CT scans reflect the high water content of the cartilaginous lesions. CT and MR imaging depict the extent of the synovial disease ( particularly surrounding soft-tissue involvement) and lobular growth. Secondary synovial chondromatosis can be distinguished from primary disease both radiologically ( underlying articular disease and fewer chondral bodies of variable size and shape) and pathologically ( concentric rings of growth). Treatment of primary disease is surgical synovectomy with removal of chondral fragments; recurrence rates range from 3% to 23%. Malignant transformation to chondrosarcoma is unusual ( 5% of cases) and, although difficult to distinguish from benign disease, is suggested by multiple recurrences and marrow invasion. Recognizing the appearances of primary synovial chondromatosis, which reflect their underlying pathologic characteristics, improves radiologic assessment and is important to optimize patient management. C1 Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. Armed Forces Inst Pathol, Dept Soft Tissue Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol & Nucl Med, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Orthoped Surg, Washington, DC 20307 USA. RP Murphey, MD (reprint author), Armed Forces Inst Pathol, Dept Radiol Pathol, 6825 16th st NW,Bldg 54,Room M-133A, Washington, DC 20306 USA. EM murphey@afip.osd.mil NR 88 TC 61 Z9 71 U1 3 U2 3 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD SEP-OCT PY 2007 VL 27 IS 5 AR 1465 DI 10.1148/rg.275075116 PG 24 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 209MS UT WOS:000249393200017 PM 17848703 ER PT J AU Smith, R AF Smith, Rogger TI Dragons at your door: How Chinese cost innovation is disrupting global competition SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Book Review C1 US Army Simulat Training & Instrumentat, Orlando, FL USA. RP Smith, R (reprint author), US Army Simulat Training & Instrumentat, Orlando, FL USA. EM rdsmith@modelbenders.com NR 1 TC 0 Z9 0 U1 1 U2 3 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD SEP-OCT PY 2007 VL 50 IS 5 BP 70 EP 71 PG 2 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA 204YI UT WOS:000249079500015 ER PT J AU Su, WJ Stepaniuk, V Otugen, MV AF Su, W-J. Stepaniuk, V. Otugen, M. V. TI Demonstration of a laser vorticity probe in turbulent boundary layers SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID LOW REYNOLDS-NUMBER; VELOCITY-GRADIENTS; STRAIN-RATE; FLUID-FLOW; WALL; SCATTERING AB A laser-based probe for the nonintrusive measurement of velocity gradient and vorticity was demonstrated in turbulent boundary layers. Unlike most other optical methods, the current technique provides an estimate of the velocity gradient, without having to first measure velocity at multiple points. The measurement principle is based on the heterodyne of coherent light scattered from two adjacent particles. The beat frequency of the heterodyne is directly proportional to the velocity gradient. The probe is assembled from commercially available, inexpensive optical components. A laser Doppler velocimeter (LDV) processor is used to analyze the heterodyne signal. A component of vorticity is obtained by using two appropriately aligned velocity gradient probes. The optical probes developed were used in turbulent boundary layers to measure local, time-frozen velocity gradients partial derivative u/partial derivative y, partial derivative v/partial derivative x, and partial derivative v/partial derivative y, as well as the spanwise vorticity. The measurements were compared to those inferred from LDV measurements in the same facility and to data available in the literature. (c) 2007 American Institute of Physics. C1 USA, Armament Res Dev & Engn Ctr, Aeroballist Div, Picatinny Arsenal, NJ 07806 USA. Lenterra Inc, W Orange, NJ 07052 USA. So Methodist Univ, Dept Engn Mech, Dallas, TX 75275 USA. RP Su, WJ (reprint author), USA, Armament Res Dev & Engn Ctr, Aeroballist Div, Picatinny Arsenal, NJ 07806 USA. NR 26 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD SEP PY 2007 VL 78 IS 9 AR 095106 DI 10.1063/1.2785155 PG 7 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 215DF UT WOS:000249787800034 PM 17902973 ER PT J AU McManus, J McClinton, A Gerhardt, R Morris, M AF McManus, John McClinton, Annette Gerhardt, Robert Morris, Michael TI Performance of ethical military research is possible: On and off the battlefield SO SCIENCE AND ENGINEERING ETHICS LA English DT Article; Proceedings Paper CT 7th International Bioethics Conference CT 7th International Bioethical Conference CY JUN 02, 2006 CY JUN 21, 2006 CL Warsaw, POLAND CL Warsaw, POLAND DE military research; combat; consent; ethics; informed consent AB Many of the same fundamental principles and regulations that govern civilian biomedical research also apply to research conducted by the US Military. Despite these similarities, the conduct of research by the US Military has additional requirements designed to preserve service members' informed consent rights, ethical standards and information that may be deemed classified. Furthermore, there are also additional rules and regulations associated with potential research to be done in a combat setting. Before conducting battlefield research, many unique circumstances must be considered to include: (1) the current legal and regulatory requirements for advanced informed consent (2) the tactical situations, and the ability to adequately document in the "austere" environment (3) the need to provide improved drugs and devices for combat casualty care and (4) the special nature of the superior-subordinate relationship. This paper discusses historical background, regulatory oversight, ethical implications and release of information as it pertains to research conducted by the US Military. C1 [McManus, John; McClinton, Annette] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Gerhardt, Robert; Morris, Michael] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP McManus, J (reprint author), USA, Inst Surg Res, 300 Rawley E,Chambers Ave B, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 10 TC 1 Z9 1 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1353-3452 EI 1471-5546 J9 SCI ENG ETHICS JI Sci. Eng. Ethics PD SEP PY 2007 VL 13 IS 3 BP 297 EP 303 DI 10.1007/s11948-007-9022-9 PG 7 WC Ethics; Engineering, Multidisciplinary; History & Philosophy Of Science; Multidisciplinary Sciences; Philosophy SC Social Sciences - Other Topics; Engineering; History & Philosophy of Science; Science & Technology - Other Topics; Philosophy GA 253UD UT WOS:000252542200004 PM 17972168 ER PT J AU Schuster, BE Wei, Q Ervin, MH Hruszkewycz, SO Miller, MK Hufnagel, TC Ramesh, KT AF Schuster, B. E. Wei, Q. Ervin, M. H. Hruszkewycz, S. O. Miller, M. K. Hufnagel, T. C. Ramesh, K. T. TI Bulk and microscale compressive properties of a Pd-based metallic glass SO SCRIPTA MATERIALIA LA English DT Article DE metallic glasses; mechanical properties; ion beam processing; nanoindentation; size-effects ID STRAIN GRADIENTS; YIELD CRITERION; DEFORMATION; PD40NI40P20; BEHAVIOR; FLOW; NANOINDENTATION; SCALE AB We present quasi-static, room temperature compression data for Pd40Ni40P20 metallic glasses for both bulk and microscale specimens. At all sizes, plastic flow is localized in shear bands which are accompanied by sudden strain bursts in the microscale tests. We show a modest (similar to 9%) increase in the 0.2% offset yield strength in going from bulk specimens to the smallest measured (similar to 2 mu m), and attribute this increase to the effect of defects on shear band initiation, rather than to an intrinsic length scale dependence of plastic deformation. (c) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. Oak Ridge Natl Lab, Div Mat Sci & Technol, Oak Ridge, TN 37831 USA. RP Schuster, BE (reprint author), AMSRD ARL WM TC, Aberdeen Proving Ground, MD 21005 USA. EM bschuster@arl.army.mil RI Wei, Qiuming/B-7579-2008; Hufnagel, Todd/A-3309-2010 OI Hufnagel, Todd/0000-0002-6373-9377 NR 22 TC 72 Z9 72 U1 2 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD SEP PY 2007 VL 57 IS 6 BP 517 EP 520 DI 10.1016/j.scriptamat.2007.05.025 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 198OY UT WOS:000248638600018 ER PT J AU Bucher, G AF Bucher, Greta TI The dilemmas of Dde-Stalinization: Negotiating cultural and social change in the Khrushchev era SO SLAVIC REVIEW LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Bucher, G (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SLAVIC STUDIES PI CAMBRIDGE PA HARVARD UNIV, 8 STORY ST, 3RD FL, CAMBRIDGE, MA 02138 USA SN 0037-6779 J9 SLAVIC REV JI Slavic Rev. PD FAL PY 2007 VL 66 IS 3 BP 563 EP 564 PG 2 WC Area Studies; Humanities, Multidisciplinary SC Area Studies; Arts & Humanities - Other Topics GA 205HS UT WOS:000249105200052 ER PT J AU Reifman, J Rajaraman, S Gribok, AV AF Reifman, Jaques Rajaraman, Srinivasan Gribok, Andrei V. TI Moving towards individualized performance models SO SLEEP LA English DT Editorial Material ID FATIGUE C1 USA, Bioinformat Cell Telemed & Adv Technol Res Ctr, MCMR ZB T, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Bioinformat Cell Telemed & Adv Technol Res Ctr, MCMR ZB T, 36 Miller Dr, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil NR 8 TC 2 Z9 2 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD SEP 1 PY 2007 VL 30 IS 9 BP 1081 EP 1082 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 208AU UT WOS:000249293000003 PM 17910378 ER PT J AU Marcus, MS Shang, L Li, B Streifer, JA Beck, JD Perkins, E Eriksson, MA Hamers, RJ AF Marcus, Matthew S. Shang, Lu Li, Bo Streifer, Jeremy A. Beck, Joseph D. Perkins, Edward Eriksson, Mark A. Hamers, Robert J. TI Dielectrophoretic manipulation and real-time electrical detection of single-nanowire bridges in aqueous saline solutions SO SMALL LA English DT Article DE bioelectronics; dietectrophoresis; nanomanipulation; nanowires; switches ID CARBON NANOTUBES; DNA; NANOPARTICLES; FABRICATION; ELECTRODES; PARTICLES; CELLS AB Dielectrophoretic manipulation of nanoscale materials is typically performed in nonionic, highly insulating solvents. However, biomolecular recognition processes, such as DNA hybridization and protein binding, typically operate in highly conducting, aqueous saline solutions. Here, we report investigations of the manipulation and real-time detection of individual nanowires bridging microelectrode gaps in saline solutions. Measurements of the electrode impedance versus frequency show a crossover in behavior at a critical frequency that is dependent on the ionic strength. We demonstrate that by operating above this critical frequency, it is possible to use dielectrophoresis to manipulate nanowires across electrode gaps in saline solutions. By using electrical ground planes and nulling schemes to reduce the background currents, we further demonstrate the ability to electrically detect bridging and unbridging events of individual nanowires in saline solutions. The ability to both manipulate and detect bridging events with electrical signals provides a pathway toward automated assembly of nanoscale devices that incorporate biomolecular recognition elements. C1 Univ Wisconsin, Dept Chem, Madison, WI 53706 USA. Univ Wisconsin, Dept Phys, Madison, WI 53706 USA. US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Hamers, RJ (reprint author), Univ Wisconsin, Dept Chem, 1101 Univ Ave, Madison, WI 53706 USA. EM rjhamers@wisc.edu RI Hamers, Robert/C-6466-2008 OI Hamers, Robert/0000-0003-3821-9625 NR 28 TC 13 Z9 13 U1 1 U2 16 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1613-6810 J9 SMALL JI Small PD SEP PY 2007 VL 3 IS 9 BP 1610 EP 1617 DI 10.1002/smll.200700130 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 210YF UT WOS:000249490800025 PM 17705314 ER PT J AU Larmore, WL Duininck, MW Morsch, GB AF Larmore, Walter L. Duininck, Mitchell W. Morsch, Gaty B. TI Spiritual needs of physicians during and following a catastrophe SO SOUTHERN MEDICAL JOURNAL LA English DT Editorial Material C1 Image Family Med Residency Program, Tulsa, OK USA. Univ Colorado, Hlth Sci Ctr, Dept Family Med, Denver, CO USA. USA, Olathe, KS USA. RP Duininck, MW (reprint author), DeLayne Kollross, 7600 S Lewis Ave, Tulsa, OK 74133 USA. EM dkollross@inhisimage.org NR 9 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD SEP PY 2007 VL 100 IS 9 BP 940 EP 941 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 213LT UT WOS:000249669600031 ER PT J AU Denton, GD Hoang, T Prince, L Moores, L Durning, S AF Denton, Gerald D. Hoang, Thanh Prince, Lisa Moores, Lisa Durning, Steve TI Accuracy of medical student electronic logbook problem list entry SO TEACHING AND LEARNING IN MEDICINE LA English DT Article AB Background: The accuracy of medical student logbooks has not been extensively studied. Purpose: The purpose of this study was to determine accuracy of student entry of core problems and completeness of patient entry in an electronic logbook. Methods: Third-year internal medicine clerkship students entered patient encounters as required by the clerkship. Experts entered information from the same encounters. Results: A total of 1,440 patient entries generated by 37 consecutive students were compared to expert entries. Sensitivity (core problem underreporting) was low (60%, SD = 22%). Percent agreement (87%, SD = 7%), kappa (0.46, SD = 0.19), and specificity (core problem overreporting; 95%, SD = 5%) were good to excellent. Students both omitted (underreported 14%, SD = 12%) and overreported (23%, sd 17%) patients. Conclusions: Under ideal study circumstances, there was significant underreporting of core problems by students. Although the high specificity, meaning that students are not reporting problems they have not encountered, is reassuring, logbook sensitivity in this study was not good enough for high-stakes evaluations of students or for medical school licensing. Copyright (C) 2007 Lawrence Erlbaum Associates, Inc. C1 Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Natl Naval Medial Ctr, Internal Med, Bethesda, MD USA. Walter Reed Army Med Ctr, Internal Med, Washington, DC USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA. RP Denton, GD (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM gdenton@usuhs.mil RI Denton, Gerald/J-8562-2012 NR 6 TC 7 Z9 7 U1 0 U2 1 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 1040-1334 J9 TEACH LEARN MED JI Teach. Learn. Med. PD FAL PY 2007 VL 19 IS 4 BP 347 EP 351 PG 5 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA 232ES UT WOS:000251001700004 PM 17935463 ER PT J AU Dabisch, PA To, F Kerut, EK Horsmon, MS Mioduszewski, RJ AF Dabisch, Paul A. To, Filip Kerut, Edmund K. Horsmon, Michael S. Mioduszewski, Robert J. TI Multiple exposures to sarin vapor result in parasympathetic dysfunction in the eye but not the heart SO TOXICOLOGICAL SCIENCES LA English DT Article DE sarin; organophosphate; heart rate variability; miosis; parasympathetic dysfunction ID RATE-VARIABILITY; MUSCARINIC RECEPTORS; ACETYLCHOLINESTERASE ACTIVITY; TERM DESENSITIZATION; PUPILLARY DILATION; SMOOTH-MUSCLE; RATS; TOLERANCE; IRIS AB Several studies in conscious animals have reported parasympathetic dysfunction in the eyes following exposure to cholinesterase inhibitors. Given the similarities between the autonomic innervation in the eye and the heart, it is possible that parasympathetic dysfunction could also occur in the heart. Therefore, the present study assessed time domain indices of heart rate variability in conscious rats surgically implanted with telemetric transmitters to investigate the hypothesis that multiple exposures to the nerve agent sarin would result in muscarinic receptor desensitization and parasympathetic dysfunction in the heart. Animals exposed to sarin vapor on multiple occasions developed parasympathetic dysfunction in the eye characterized by an attenuated response to light and a diminished miotic response to sarin vapor exposure. However, the same dose of sarin vapor failed to produce any effects on either time domain indices of HRV or the magnitude of the tachycardia induced by atropine, suggesting that autonomic control in the heart was not affected. It is possible that the dose of sarin used in the present study was insufficient to inhibit cardiac acetylcholinesterase (AChE). Additional studies utilizing higher doses of sarin may be able to inhibit cardiac ACNE, producing overstimulation of cardiac muscarinic receptors, ultimately resulting in desensitization and parasympathetic dysfunction. C1 USA, Edgewood Chem Biol Ctr, Operat Toxicol Team, ATTN,AMSRD,ECB,RT,TT, Aberdeen Proving Ground, MD 21010 USA. Mississippi State Univ, Dept Agr & Biol Engn, Mississippi State, MS 39762 USA. Louisiana State Univ, Sch Med, New Orleans, LA 70112 USA. RP Dabisch, PA (reprint author), USA, Edgewood Chem Biol Ctr, Operat Toxicol Team, ATTN,AMSRD,ECB,RT,TT, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM paul.a.dabisch@us.army.mil NR 34 TC 5 Z9 5 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 J9 TOXICOL SCI JI Toxicol. Sci. PD SEP PY 2007 VL 99 IS 1 BP 354 EP 361 DI 10.1093/toxsci/kfm167 PG 8 WC Toxicology SC Toxicology GA 205XK UT WOS:000249148300036 PM 17578861 ER PT J AU Selvapandiyan, A Duncan, R Mendez, J Card, LJ Nakhasil, H AF Selvapandiyan, A. Duncan, R. Mendez, J. Card, L. J. Nakhasil, H. TI Evaluation of a sensitive PCIR assay for rapid identification of leishmania SP ecies from blood samples SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. EM lisa.cardo@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 8A EP 9A PG 2 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600023 ER PT J AU Cardo, LJ O'Sullivan, A AF Cardo, L. J. O'Sullivan, A. TI Accumulation of plasminogen activator inhibitor-1 (PAI-1) in pRBCs is reduced by WB leukodepletion filters SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM Lisa.Cardo@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 32A EP 32A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600088 ER PT J AU Evans, CL Hmel, PJ MacDonald, VW AF Evans, C. L. Hmel, P. J. MacDonald, V. W. TI A new system for shipping FFP without breakage SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM Victor.Macdonald@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 74A EP 74A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600213 ER PT J AU Hmel, PJ MacDonald, VW AF Hmel, P. J. MacDonald, V. W. TI Viability of lyophilized swine fresh frozen plasma SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM Victor.Macdonald@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 76A EP 76A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600218 ER PT J AU Hoiles, J MacDonald, VW AF Hoiles, J. MacDonald, V. W. TI Characterization of the storage lesion of whole-b lood -derived porcine platelets SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM Victor.Macdonald@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 84A EP 84A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600241 ER PT J AU Cardo, LJ Salata, J Zobrist, B AF Cardo, L. J. Salata, J. Zobrist, B. TI Accumulation of annexin v in pRBCs during storage is reduced by WB leukodepletion filters SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM Lisa.Cardo@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 85A EP 85A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600245 ER PT J AU Cardo, LJ O'Sullivan, A AF Cardo, L. J. O'Sullivan, A. TI Accumulation of soluble p-selectin (sP-selectin) in pRBCs is reduced by WB leukodepletion filters SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM Lisa.Cardo@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 85A EP 85A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600244 ER PT J AU Cardo, LJ O'Sullivan, A AF Cardo, L. J. O'Sullivan, A. TI Unfiltered, but not filtered, washed pRBCs prime mononuclear leukocytes for the production of IL-8 SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM Lisa.Cardo@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 89A EP 90A PG 2 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600257 ER PT J AU McFaul, SJ Govil, A Murphy, CL Corley, JB Mester, CW AF McFaul, S. J. Govil, A. Murphy, C. L. Corley, J. B. Mester, C. W. TI Pro-inflammatory characteristics of supernates from pRBCs stored in AS-3, AS-5, and an experimental eight-week additive solution SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM steve.mcfaul@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 90A EP 90A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600258 ER PT J AU Culpepper, J MacDonald, VW AF Culpepper, J. MacDonald, V. W. TI Preconditioning phase change materials in shipping containers - The effect of ultra-low temperatures on load temperature distribution SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM Victor.Macdonald@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 93A EP 93A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600267 ER PT J AU McFaul, SJ Mester, CW Corley, J AF McFaul, S. J. Mester, C. W. Corley, J. TI Neutrophils are primed by supernates from pRBCs stored in an experimental eight week additive solution SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM steve.mcfaul@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 93A EP 93A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600266 ER PT J AU Cardo, LJ Swingholm, M AF Cardo, L. J. Swingholm, M. TI Secretory phospholipase A2 in pRBCs SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. EM lisa.cardo@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 94A EP 94A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600270 ER PT J AU Rentas, FJ Houchens, D MacDonald, VW AF Rentas, F. J. Houchens, D. MacDonald, V. W. TI An "Iceless" OR container capable of keeping red blood cells at 1-6 degrees C for over 11 hours SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. EM frank.rentas@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 95A EP 95A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600272 ER PT J AU Wagner, SJ Skripchenko, A Salata, J O'Sullivan, A Cardo, LJ AF Wagner, S. J. Skripchenko, A. Salata, J. O'Sullivan, A. Cardo, L. J. TI Inactivation of Leishmania donavani infantum and Trypanosoma cruzi in human red cell suspensions by thiazole orange SO TRANSFUSION LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-of-Blood-Banks CY OCT 20-23, 2007 CL Anaheim, CA SP Amer Assoc Blood Banks C1 Amer Red Cross, Rockville, MD 20855 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. EM wagners@usa.redcross.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2007 VL 47 IS 3 SU S BP 131A EP 131A PG 1 WC Hematology SC Hematology GA 209OJ UT WOS:000249397600383 ER PT J AU Sears, CLG Schenkman, N Lockrow, EG AF Sears, Christine L. Gray Schenkman, Noah Lockrow, Ernest G. TI Use of end-to-end anastornotic sizer with occlusion balloon to prevent loss of pneumoperitoneum in robotic vesicovaginal fistula repair SO UROLOGY LA English DT Article ID RECONSTRUCTION; HYSTERECTOMY AB Maintaining the pneumoperitoneum in robotic-assisted surgery can be difficult when vaginal integrity is compromised, such as in vesicovaginal fistula. We report an approach using an anastomotic sizer modified with an occlusion balloon for manipulation of the vaginal apex and maintenance of the pneumoperitoneum for robotic-assisted vesicovaginal fistula repair. C1 Walter Reed Army Med Ctr, Dept Urol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Obstet, Washington, DC USA. Walter Reed Army Med Ctr, Dept Gynecol, Washington, DC USA. Univ Virginia, Dept Obstet, Charlottesville, VA USA. Univ Virginia, Dept Gynecol, Charlottesville, VA USA. Univ Virginia, Dept Urol, Charlottesville, VA USA. RP Sears, CLG (reprint author), Walter Reed Army Med Ctr, Dept Urol, 6900 Georgia ave NW, Washington, DC 20307 USA. EM Christine.Sears@amedd.army.mil NR 9 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD SEP PY 2007 VL 70 IS 3 BP 581 EP 582 DI 10.1016/j.urology.2007.05.026 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA 226AC UT WOS:000250558500048 PM 17905121 ER PT J AU Medendorp, AR Albrecht, MC Morey, AF AF Medendorp, Andrew R. Albrecht, Michael C. Morey, Allen F. TI Natural history of extensive, full-thickness electrical burns involving the penis SO UROLOGY LA English DT Article C1 USA, Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX USA. RP Morey, AF (reprint author), Univ Texas, SW Med Ctr, Dept Urol, 5323 Harry Hines Blvd, Houston, TX 75390 USA. EM allen.morey@cen.amedd.army.mil NR 4 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD SEP PY 2007 VL 70 IS 3 BP 588 EP 589 DI 10.1016/j.urology.2007.07.028 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA 226AC UT WOS:000250558500050 PM 17905122 ER PT J AU Mills, JN Alva, H Ellis, BA Wagoner, KD Childs, JE Calderon, G Enria, DA Jahrling, PB AF Mills, James N. Alva, Herminia Ellis, Barbara A. Wagoner, Kent D. Childs, James E. Calderon, Gladys Enria, Delia A. Jahrling, Peter B. TI Dynamics of oliveros virus infection in rodents in central Argentina SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE epidemiology; field studies; rodent-borne; zoonotic ID SIN-NOMBRE-VIRUS; JUNIN VIRUS; HEMORRHAGIC-FEVER; LONG-TERM; POPULATIONS; PREVALENCE; ARENAVIRUS; RESERVOIR; COLORADO AB Oliveros virus (OLV) is an arenavirus hosted by the sigmodontine rodent, Necromys benefactus, in central Argentina. We report a 3-year longitudinal field study of the dynamics of OLV infection in host populations from 15 localities in two provinces on the central Argentine pampa. There was an overall 3-year period immunofluorescent antibody prevalence of 25% in the host population, and infected hosts were found throughout the study area. Spill-over infection into common sympatric species was rare. Infection dynamics exhibited many of the patterns seen for other rodent-borne arenaviruses and hantaviruses, but had some unique characteristics. Host population density was highest in autumn and lowest in spring, while antibody prevalence was highest in spring and lowest in autumn. Virus transmission was horizontal: infection was strongly associated with age, reaching 45% prevalence in the oldest individuals, and prevalence of infection was equal among male and female hosts. Infection may have been associated with scars, which were also approximately equally distributed among male and female Necromys. C1 Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Atlanta, GA 30329 USA. Tulane Univ, Sch Publ Hlth, New Orleans, LA 70118 USA. Ctr Dis Control & Prevent, Coordinating Off Terr Preparedness Emergency Resp, Atlanta, GA USA. Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA. Inst Nacl Enfermedades Virales Humanas, Pergamino, Argentina. US Army Med Res Inst Infect Dis, Frederick, MD USA. Ithaca Coll, Dept Exercise & Sport Sci, Ithaca, NY USA. RP Mills, JN (reprint author), Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Atlanta, GA 30329 USA. EM jum0@cdc.gov RI Childs, James/B-4002-2012 NR 27 TC 5 Z9 5 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD FAL PY 2007 VL 7 IS 3 BP 315 EP 323 DI 10.1089/vbz.2006.0599 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 218LX UT WOS:000250018100004 PM 17760514 ER PT J AU Twenhafel, NA Leffel, E Pitt, MLM AF Twenhafel, N. A. Leffel, E. Pitt, M. L. M. TI Pathology of inhalational anthrax infection in the African green monkey SO VETERINARY PATHOLOGY LA English DT Article DE African green monkeys; anthrax; Bacillus anthracis; biologic warfare agent; inhalation anthrax disease; rhesus macaques ID RESPIRATORY ANTHRAX; MACACA MULATTA; PATHOGENESIS; VIRUS; LIVE AB There is a critical need for an alternative nonhuman primate model for inhalational anthrax infection because of the increasingly limited supply and cost of the current model. This report describes the pathology in 12 African green monkeys (AGMs) that succumbed to inhalational anthrax after exposure to a low dose (presented dose 200-2 X 10(4)colony-forming units [cfu]) or a high dose (presented dose 2 x 10(4)-1 x 10(7) Cfu) of Bacillus anthracis (Ames strain) spores. Frequent gross lesions noted in the AGM were hemorrhage and edema in the lung, mediastinum, and mediastinal lymph nodes; pleural and pericardial effusions; meningitis; and gastrointestinal congestion and hemorrhage. Histopathologic findings included necrohemorrhagic lymphadenitis of mediastinal, axillary, inguinal, and mesenteric lymph nodes; mediastinal edema; necrotizing splenitis; meningitis; and congestion, hemorrhage, and edema of the lung, mesentery, mesenteric lymph nodes, gastrointestinal tract, and gonads. Pathologic changes in AGMs were remarkably similar to what has been reported in rhesus macaques and humans that succumbed to inhalational anthrax; thus, AGMs could serve as useful models for inhalation anthrax studies. C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Twenhafel, NA (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM nancy.twenhafel@us.army.mil NR 11 TC 27 Z9 27 U1 0 U2 1 PU AMER COLL VET PATHOLOGIST PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD SEP PY 2007 VL 44 IS 5 BP 716 EP 721 DI 10.1354/vp.44-5-716 PG 6 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA 219BT UT WOS:000250060400022 PM 17846250 ER PT J AU Goff, A Twenhafel, N Garrison, A Mucker, E Lawler, J Paragas, J AF Goff, Arthur Twenhafel, Nancy Garrison, Aura Mucker, Eric Lawler, James Paragas, Jason TI In vivo imaging of cidofovir treatment of cowpox virus infection SO VIRUS RESEARCH LA English DT Article DE Orthopoxvirus; cowpox virus; smallpox; bioterrorism; biodefense imaging ID VACCINIA VIRUS; AEROSOLIZED CIDOFOVIR; MOLLUSCUM CONTAGIOSUM; POXVIRUS INFECTIONS; HUMAN MONKEYPOX; PROTECTS MICE; REPLICATION; EFFICACY; PHARMACOKINETICS; BIOAVAILABILITY AB Variola virus and other members of the genus Orthopoxviruses constitute a prominent bioterrorism and public health threat. Treatment with the anti-viral drug cidofovir inhibits replication of orthopoxviruses in vitro and in vivo. In this study, we visualized the effect of cidofovir on viral kinetics in orthopoxvirus infected mice by using whole-body fluorescence imaging (171). We engineered a cowpox virus (CPV) expressing the enhanced green fluorescent protein (GFP). Single-step growth curves and calculated 50% lethal doses (LD50) of wild-type CPX (Wt-CPV) and GFP-expressing CPX (GFP-CPV) were comparable. Whole-body FI first detected GFP fluorescence in the mesenteric tissue of untreated animals on post-infection day (PID) 1. On PID 3 GFP signal was detected throughout the mesentery, in all abdominal organs by PID 5 and in most major organs, except for the heart and brain by PID 6. Infected animals treated with 25 mg/kg of cidofovir also began showing signs of viral replication on PID 1, however, the fluorescent signal was limited only to discrete foci throughout the course of the infection. This work describes the first use of an established Orthopox model of infection to evaluate drug efficacy and track virus progression on a macroscopic level. (C) 2007 Elsevier B.V. All rights reserved. C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Med, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Goff, A (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM Arthur.Goff@det.amedd.army.mil NR 34 TC 13 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD SEP PY 2007 VL 128 IS 1-2 BP 88 EP 98 DI 10.1016/j.virusres.2007.04.014 PG 11 WC Virology SC Virology GA 208HP UT WOS:000249310700012 PM 17524511 ER PT J AU Doherty, KJ Tice, JR Szewczyk, SI Gilde, GA AF Doherty, Kevin J. Tice, Jason R. Szewczyk, Steven I. Gilde, Gary A. TI Brazing titanium for structural and vehicle applications SO WELDING JOURNAL LA English DT Editorial Material C1 USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Doherty, KJ (reprint author), USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. EM kdoherty@arl.army.mil OI doherty, kevin/0000-0002-5806-5283 NR 5 TC 4 Z9 4 U1 0 U2 0 PU AMER WELDING SOC PI MIAMI PA 550 N W LEJEUNE RD, MIAMI, FL 33126 USA SN 0043-2296 J9 WELD J JI Weld. J. PD SEP PY 2007 VL 86 IS 9 BP 41 EP 46 PG 6 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA 207KG UT WOS:000249249400007 ER PT J AU Krawczyk, S AF Krawczyk, Scott TI Literary couplings: Writing couples, collaborators, and the construction of authorship SO WORDSWORTH CIRCLE LA English DT Book Review C1 [Krawczyk, Scott] US Mil Acad, West Point, NY 10996 USA. RP Krawczyk, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK UNIV PI NEW YORK PA C/O PROF MARILYN GAULL, DEPT ENGLISH, NEW YORK, NY 10003-4556 USA SN 0043-8006 J9 WORDSWORTH CIRCLE JI Wordsworth Circle PD FAL PY 2007 VL 38 IS 4 BP 186 EP 188 PG 3 WC Poetry SC Literature GA 313OI UT WOS:000256749500024 ER PT J AU Petit, C Karwacki, C Peterson, G Bandosz, TJ AF Petit, Camille Karwacki, Christopher Peterson, Greg Bandosz, Teresa J. TI Interactions of ammonia with the surface of microporous carbon impregnated with transition metal chlorides SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID ACTIVATED CARBON; NH3 ADSORPTION; ACID SITES; REMOVAL; FIBERS; WATER AB The BPL carbon samples impregnated with chlorides of copper, nickel, and zinc were used as ammonia adsorbents in dynamic conditions with various amounts of water present in the systems. The initial and exhausted samples were characterized using adsorption of nitrogen, XRF, XRD, FTIR, SEM, and thermal analysis. The results indicate that metal chlorides are active centers for ammonia adsorption via formation of complexes. Water enhances the amount of ammonia adsorbed, promoting its dissolving into the film of water adsorbed in micropores and formation of NH4+ ions. Even though the pore system of activated carbon provides spaces for dispersion of metals, it still contributes significantly to the amount of ammonia adsorbed (about 80%) via dispersive forces. The most efficient adsorbent for ammonia removal is the carbon impregnated with copper. In this material the efficiency is governed by the amount of copper introduced to the carbon and its dispersion on the surface. C1 CUNY City Coll, Dept Chem, New York, NY 10038 USA. Ecole Natl Super Chim Montpellier, F-34296 Montpellier, France. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Bandosz, TJ (reprint author), CUNY City Coll, Dept Chem, 160 Convent Ave, New York, NY 10038 USA. EM tbandosz@ccny.cuny.edu RI Petit, Camille/I-4732-2014 NR 34 TC 66 Z9 67 U1 5 U2 36 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD AUG 30 PY 2007 VL 111 IS 34 BP 12705 EP 12714 DI 10.1021/jp072066n PG 10 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 202UK UT WOS:000248929100034 ER PT J AU Hammamieh, R Barmada, M Ludwig, G Peel, S Koterski, N Jett, M AF Hammamieh, Rasha Barmada, Mohsen Ludwig, George Peel, Sheila Koterski, Nick Jett, Marti TI Blood genomic profiles of exposures to Venezuelan equine encephalitis in Cynomolgus macaques (Macaca fascicularis) SO VIROLOGY JOURNAL LA English DT Article ID INFECTION; VIRUS; MICE AB Background: Lymphocytes provide invaluable whistle blowers of changes due to infections. We use the information registered by these cells using their mRNAs as they encounter the pathogen to develop patterns of expression that correspond to that specific pathogen. Venezuelan equine encephalitis (VEE) is a mosquito- borne viral disease characterized by fever and one or more of the following: severe headache, back pain, myalgias, prostration, chills, nausea, vomiting, weakness and other flu-like symptoms. Screening for host mRNA obtained from blood samples after exposure to VEEV may provide the means for early detection of surrogate markers of the impending illness and provide appropriate strategies for treatment. Results: We have been carrying out gene expression analysis of PBMC exposed to VEEV to extract signatures and diagnostic markers of early exposure to be used in non invasive blood analysis methods. In this study, we used high throughput gene expression analysis to identify markers of early and late exposures to VEEV in vivo in Cynomolgus macaques (Macaca fascicularis). We carried out cDNA microarrays and real time PCR on blood samples obtained from the NHP model resulting in a panel of host genes that are altered in response to VEEV. Conclusion: Screening for host mRNA obtained from blood samples after exposure to VEEV may provide the means for early detection of surrogate markers of the impending illness and provide appropriate strategies for treatment. C1 Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. USA, Med Res & Mat Command, Off Principal Assistant Res & Technol, Frederick, MD USA. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. USA, Med Res & Mat Command, Div Virol, Frederick, MD USA. RP Jett, M (reprint author), Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. EM rasha.hammamieh@na.amedd.army.mil; mohsen.barmada@na.amedd.army.mil; George.Ludwig@us.army.mil; speel@hivresearch.org; james.koterski@jtfcs.northcom.mil; marti.jett@us.army.mil NR 11 TC 10 Z9 10 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD AUG 29 PY 2007 VL 4 AR 82 DI 10.1186/1743-422X-4-82 PG 11 WC Virology SC Virology GA 224PG UT WOS:000250458300002 PM 17727720 ER PT J AU Arumugam, TV Tang, SC Lathia, JD Cheng, A Mughal, MR Chigurupati, S Magnus, T Chan, SL Jo, DG Ouyang, X Fairlie, DP Granger, DN Vortmeyer, A Basta, M Mattson, MP AF Arumugam, Thiruma V. Tang, Sung-Chun Lathia, Justin D. Cheng, Aiwu Mughal, Mohamed R. Chigurupati, Srinivasulu Magnus, Tim Chan, Sic L. Jo, Dong-Gyu Ouyang, Xin Fairlie, David P. Granger, Daniel N. Vortmeyer, Alexander Basta, Milan Mattson, Mark P. TI Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE C5a; cerebral cortex apoptosis; ischemic stroke; lymphocyte; microglia ID FOCAL CEREBRAL-ISCHEMIA; TISSUE-PLASMINOGEN-ACTIVATOR; HUMAN ALBUMIN; THERAPY; C5A; NEUROPROTECTION; PERFUSION; ADHESION; RECEPTOR; SYSTEM AB Stroke is among the three leading causes of death worldwide and the most frequent cause of permanent disability. Brain ischemia induces an inflammatory response involving activated complement fragments. Here we show that i.v. Ig (IVIG) treatment, which scavenges complement fragments, protects brain cells against the deleterious effects of experimental ischemia and reperfusion (I/R) and prevents I/R-induced mortality in mice. Animals administered IVIG either 30 min before ischemia or after 3 h of reperfusion exhibited a 50-60% reduction of brain infarct size and a 2- to 3-fold improvement of the functional outcome. Even a single low dose of IVIG given after stroke was effective. IVIG was protective in the nonreperfusion model of murine stroke as well and did not exert any peripheral effects. Human IgG as well as intrinsic murine C3 levels were significantly higher in the infarcted brain region compared with the noninjured side, and their physical association was demonstrated by immuno-coprecipitation. C5-deficient mice were significantly protected from I/R injury compared with their wild-type littermates. Exposure of cultured neurons to oxygen/glucose deprivation resulted in increased levels of C3 associated with activation of caspase 3, a marker of apoptosis; both signals were attenuated with IVIG treatment. Our data suggest a major role for complement-mediated cell death in ischemic brain injury and the prospect of using IVIG in relatively low doses as an interventional therapy for stroke. C1 NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA. Texas Tech Univ, Hlth Sci Ctr, Dept Pharmaceut Sci, Amarillo, TX 79106 USA. Univ Cent Florida, Biomol Sci Ctr, Orlando, FL 32816 USA. Louisiana State Univ, Hlth Sci Ctr, Dept Cellular & Mol Physiol, Shreveport, LA 71130 USA. Natl Taiwan Univ Hosp, Dept Neurol, Yun Lin Branch, Yunlin 640, Taiwan. Univ Queensland, Inst Mol Biosci, Ctr Drug Design & Dev, Brisbane, Qld 4072, Australia. NINDS, Neuronal Excitabil Sect, NIH, Bethesda, MD 20892 USA. NINDS, Div Neurosurg, NIH, Bethesda, MD 20892 USA. Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA. RP Basta, M (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave,Room 1N11, Silver Spring, MD 20910 USA. EM basta.milan@gmaii.com RI Arumugam, Thiruma/C-7969-2009; Arumugam, Thiruma/B-4898-2011; Mattson, Mark/F-6038-2012; Fairlie, David/F-8865-2014; OI Basta, Milan/0000-0001-5958-9241; Tang, Sung-Chun/0000-0003-3731-5973; Fairlie, David/0000-0002-7856-8566 FU NHLBI NIH HHS [R01 HL026441, HL26441] NR 29 TC 100 Z9 104 U1 1 U2 11 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 28 PY 2007 VL 104 IS 35 BP 14104 EP 14109 DI 10.1073/pnas.0700506104 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 206ML UT WOS:000249187500045 PM 17715065 ER PT J AU Suleiman, D Napadensky, E Sloan, JM Crawford, DM AF Suleiman, David Napadensky, Eugene Sloan, James M. Crawford, Dawn M. TI Thermogravimetric characterization of highly sulfonated poly (styrene-isobutylene-styrene) block copolymers: Effects of sulfonation and counter-ion substitution SO THERMOCHIMICA ACTA LA English DT Article DE poly(styrene-isobutylene-styrene) block copolymers; ion-exchange membranes; cross-linked membranes; thermogravimetric properties ID MECHANICAL-PROPERTIES; TRIBLOCK COPOLYMERS; MEMBRANES; IONOMERS; POLYSTYRENE; TRANSPORT; METHANOL; BLENDS AB In this study, poly(styrene-isobutylene-styrene) (SIBS) block copolymers were characterized by thermogravimetry as a function of sulfornation level (53-97%) and counter-ion substitution (Mg2+, Ca2+, Ba2+). Sulfonated samples showed an additional minor loss of mass at approximately 290 +/- 2 degrees C, which was not observed in the unsulfornated polymer. At this temperature, desulfonation or a cleavage reaction of the aromatic carbon-sulfur bond occurs. The counter-ion substituted membranes did not show the degradation temperature at 290 degrees C, but additional unique degradation temperatures above 500 degrees C, suggesting improved thermal stability for the ionically cross-linked polymer with cations. Some cations (Mg-2+,Mg- Ca2+, Ba2+), showed multiple high temperature degradations, which suggest that different cross-linked structures are formed throughout the phase segregated morphology. Published by Elsevier B.V. C1 Univ Puerto Rico, Dept Chem Engn, Mayaguez, PR 00681 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Suleiman, D (reprint author), Univ Puerto Rico, Dept Chem Engn, Mayaguez, PR 00681 USA. EM dsuleiman@uprm.edu NR 19 TC 21 Z9 21 U1 0 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0040-6031 J9 THERMOCHIM ACTA JI Thermochim. Acta PD AUG 25 PY 2007 VL 460 IS 1-2 BP 35 EP 40 DI 10.1016/j.tca.2007.05.012 PG 6 WC Thermodynamics; Chemistry, Analytical; Chemistry, Physical SC Thermodynamics; Chemistry GA 200SY UT WOS:000248784300006 ER PT J AU O'Malley, PG AF O'Malley, Patrick G. TI Heat waves and heat-related illness - Preparing for the increasing influence of climate on health in temperate areas SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID WEATHER C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Bethesda, MD USA. RP O'Malley, PG (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM patrick.omalley@amedd.army.mil NR 9 TC 3 Z9 4 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 22 PY 2007 VL 298 IS 8 BP 917 EP 919 DI 10.1001/jama.298.8.917 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 202CS UT WOS:000248880200025 PM 17715490 ER PT J AU Tang, J Park, JG Millard, CB Schmidt, JJ Pang, YP AF Tang, Jing Park, Jewn Giew Millard, Charles B. Schmidt, James J. Pang, Yuan-Ping TI Computer-Aided Lead Optimization: Improved Small-Molecule Inhibitor of the Zinc Endopeptidase of Botulinum Neurotoxin Serotype A SO PLOS ONE LA English DT Article AB Optimization of a serotype-selective, small-molecule inhibitor of botulinum neurotoxin serotype A (BoNTA) endopeptidase is a formidable challenge because the enzyme-substrate interface is unusually large and the endopeptidase itself is a large, zinc-binding protein with a complex fold that is difficult to simulate computationally. We conducted multiple molecular dynamics simulations of the endopeptidase in complex with a previously described inhibitor (K(i)(app) of 7+/-2.4 mu M) using the cationic dummy atom approach. Based on our computational results, we hypothesized that introducing a hydroxyl group to the inhibitor could improve its potency. Synthesis and testing of the hydroxyl-containing analog as a BoNTA endopeptidase inhibitor showed a twofold improvement in inhibitory potency (K(i)(app) of 3.8+/-0.8 mu M) with a relatively small increase in molecular weight (16 Da). The results offer an improved template for further optimization of BoNTA endopeptidase inhibitors and demonstrate the effectiveness of the cationic dummy atom approach in the design and optimization of zinc protease inhibitors. C1 [Schmidt, James J.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD USA. [Tang, Jing; Park, Jewn Giew; Pang, Yuan-Ping] Mayo Clin, Comp Aided Mol Design Lab, Rochester, MN USA. [Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD USA. RP Schmidt, JJ (reprint author), USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD USA. EM james.schmidt@det.amedd.army.mil; pang@mayo.edu OI Pang, Yuan-Ping/0000-0003-0838-2560 FU Advanced Research Projects Agency [DAAD19-01-10322]; U.S. Army Medical Research Acquisition Activity [W81XWH-04-2-0001]; National Institutes of Health/National Institute of Allergy and Infectious Diseases [5R01AI054574-03] FX Supported by Advanced Research Projects Agency (DAAD19-01-10322), the U.S. Army Medical Research Acquisition Activity (W81XWH-04-2-0001), and the National Institutes of Health/National Institute of Allergy and Infectious Diseases (5R01AI054574-03). NR 52 TC 35 Z9 35 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 22 PY 2007 VL 2 IS 8 AR e761 DI 10.1371/journal.pone.0000761 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA V10HO UT WOS:000207455300009 PM 17712409 ER PT J AU Haskins, RW Maier, RS Ebeling, RM Marsh, CP Majure, DL Bednar, AJ Welch, CR Barker, BC Wu, DT AF Haskins, Richard W. Maier, Robert S. Ebeling, Robert M. Marsh, Charles P. Majure, Dustin L. Bednar, Anthony J. Welch, Charles R. Barker, Bruce C. Wu, David T. TI Tight-binding molecular dynamics study of the role of defects on carbon nanotube moduli and failure SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MECHANICAL-PROPERTIES; VACANCY DEFECTS; WS2 NANOTUBES; BEHAVIOR; FRACTURE; SIMULATION; STRENGTH; BREAKING; TENSION AB We performed tight-binding molecular dynamics on single-walled carbon nanotubes with and without a variety of defects to study their effect on the nanotube modulus and failure through bond rupture. For a pristine (5,5) nanotube, Young's modulus was calculated to be similar to 1.1 TPa, and brittle rupture occurred at a strain of 17% under quasistatic loading. The predicted modulus is consistent with values from experimentally derived thermal vibration and pull test measurements. The defects studied consist of moving or removing one or two carbon atoms, and correspond to a 1.4% defect density. The occurrence of a Stone-Wales defect does not significantly affect Young's modulus, but failure occurs at 15% strain. The occurrence of a pair of separated vacancy defects lowers Young's modulus by similar to 160 GPa and the critical or rupture strain to 13%. These defects apparently act independently, since one of these defects alone was independently determined to lower Young's modulus by similar to 90 GPa, also with a critical strain of 13%. When the pair of vacancy defects adjacent, however, Young's modulus is lowered by only similar to 100 GPa, but with a lower critical strain of 11%. In all cases, there is noticeable strain softening, for instance, leading to an similar to 250 GPa drop in the apparent secant modulus at 10% strain. When a chiral (10,5) nanotube with a vacancy defect was subjected to tensile strain, failure occurred through a continuous spiral-tearing mechanism that maintained a high level of stress (2.5 GPa) even as the nanotube unraveled. Since the statistical likelihood of defects occurring near each other increases with nanotube length, these studies may have important implications for interpreting the experimental distribution of moduli and critical strains. (C) 2007 American Institute of Physics. C1 USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. Colorado Sch Mines, Dept Chem Engn, Golden, CO 80401 USA. Colorado Sch Mines, Dept Chem, Golden, CO 80401 USA. RP Haskins, RW (reprint author), USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. EM richard.w.haskins@erdc.usace.army.mil NR 37 TC 41 Z9 42 U1 2 U2 6 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD AUG 21 PY 2007 VL 127 IS 7 AR 074708 DI 10.1063/1.2756832 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 202MH UT WOS:000248905300029 PM 17718628 ER PT J AU Huang, YJ Huang, Y Baldassarre, H Wang, B Lazaris, A Leduc, M Bilodeau, AS Bellemare, A Cote, M Herskovits, P Touati, M Turcotte, C Valeanu, L Lemee, N Wilgus, H Begin, I Bhatia, B Rao, K Neveu, N Brochu, E Pierson, J Hockley, DK Cerasoli, DM Lenz, DE Karatzas, CN Langermann, S AF Huang, Yue-Jin Huang, Yue Baldassarre, Hernan Wang, Bin Lazaris, Anthoula Leduc, Martin Bilodeau, Annie S. Bellemare, Annie Cote, Malanie Herskovits, Peter Touati, Madjid Turcotte, Carl Valeanu, Loreclana Lemee, Nicolas Wilgus, Harvey Begin, Isabelle Bhatia, Bhim Rao, Khalid Neveu, Nathalie Brochu, Eric Pierson, Janice Hockley, Duncan K. Cerasoli, Douglas M. Lenz, David E. Karatzas, Costas N. Langermann, Solomon TI Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE organophosphorus nerve agent; recombinant protein expression; transgenic production ID NERVE AGENT TOXICITY; OVUM PICK-UP; IN-VITRO; NUCLEAR TRANSFER; CLONED GOATS; HALF-LIFE; EXPRESSION; ACETYLCHOLINESTERASE; CHOLINESTERASES; LIVESTOCK AB Dangerous organophosphorus (OP) compounds have been used as insecticides in agriculture and in chemical warfare. Because exposure to OP could create a danger for humans in the future, butyrylcholinesterase (BChE) has been developed for prophylaxis to these chemicals. Because it is impractical to obtain sufficient quantities of plasma BChE to treat humans exposed to OP agents, the production of recombinant BChE (rBChE) in milk of transgenic animals was investigated. Transgenic mice and goats were generated with human BChE cDNA under control of the goat beta-casein promoter. Milk from transgenic animals contained 0.1-5 g/liter of active rBChE. The plasma half-life of PEGylated, goat-derived, purified rBChE in guinea pigs was 7-fold longer than non-PEGylated dimers. The rBChE from transgenic mice was inhibited by nerve agents at a 1:1 molar ratio. Transgenic goats produced active rBChE in milk sufficient for prophylaxis of humans at risk for exposure to OP agents. C1 PharmAthene Canada Inc, Montreal, PQ H4S 2C8, Canada. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Huang, YJ (reprint author), PharmAthene Canada Inc, 7150 Alexander Fleming, Montreal, PQ H4S 2C8, Canada. EM yihuang@pharmathene.ca NR 32 TC 114 Z9 126 U1 1 U2 11 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 21 PY 2007 VL 104 IS 34 BP 13603 EP 13608 DI 10.1073/pnas.0702756104 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 204SQ UT WOS:000249064700016 PM 17660298 ER PT J AU Lar, P Lar, N Bemis, K Jelpe, J Enzyguirre, L Ayuba, L Zella, D Kanki, P Carr, JK Blattner, W Abimiku, AG AF Lar, P. Lar, N. Bemis, K. Jelpe, J. Enzyguirre, L. Ayuba, L. Zella, D. Kanki, P. Carr, J. K. Blattner, W. Abimiku, A. G. TI HIV subtype and drug resistance patterns among drug naive persons in Jos, Nigeria SO AFRICAN JOURNAL OF BIOTECHNOLOGY LA English DT Article DE characterization; CRF02_AG; baseline; niverapine; unique recombinant forms; West Africa ID IMMUNODEFICIENCY-VIRUS TYPE-1; REVERSE-TRANSCRIPTASE; PROTEASE; MUTATIONS; STRAINS; SUSCEPTIBILITY; SEQUENCES; CAMEROON; PANEL AB To determine HIV- 1 subtypes and antiretroviral drug resistance mutations for 16 infected, pregnant women in Jos, Nigeria, part of pol ( 1040 bp) was amplified from patient PBMC DNA, sequenced and analyzed. Eight of the samples were subtype G, three were CRF02_AG and 2 were unique recombinant forms (URF) between G and CRF02_AG. The remaining consisted of 3 different strains: one was subtype C, and the other 2 were unrelated URF. Nearly full- length genome sequences were completed for 6 of the strains: 4 subtype G and 2 CRF02_AG. In the 14 drug-naive subjects, no primary resistance- associated mutations were found, but secondary mutations were identified in 7 different codons of the gene coding for protease: PR K20I, M36I, L63A/ P/ V, V82I, L10M/ I and 193L. In addition, the K238R mutation was identified in the reverse transcriptase gene of 3 viruses. The PR K20I and M36I mutations occurred in all of the strains, and the L10M and V82I mutations occurred only in subtype G. The mutation, I93L, was carried by subtype C viruses. Two of the women that had prior niverapine treatment, had primary resistance- associated mutations, RT M184V and K103N, archived in their proviral DNA several months after treatment cessation. The study reports a predominance of clade G and CRF02_ AG, and provides many more examples of nearly full- length genome sequences for subtype G viruses from Nigeria. The ubiquitous presence of PI secondary resistance- associated mutations, as well as primary resistance-associated mutations in 2 previously treated women, underscores the need to ensure adherence compliance to treatment. C1 Univ Maryland, Inst Human Virol, Baltimore, MD 21201 USA. Harvard Univ, Sch Publ Hlth, Boston, MA USA. Walter Reed Army Inst Res, Rockville, MD USA. Univ Jos, Jos, Nigeria. RP Lar, P (reprint author), Univ Maryland, Inst Human Virol, Baltimore, MD 21201 USA. EM larp1000ng@yahoo.com NR 26 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC JOURNALS PI NAIROBI PA P O BOX 5170-00200, NAIROBI, 00000, KENYA SN 1684-5315 J9 AFR J BIOTECHNOL JI Afr. J. Biotechnol. PD AUG 20 PY 2007 VL 6 IS 16 BP 1892 EP 1897 PG 6 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 209VE UT WOS:000249415300008 ER PT J AU Winter, WE Maxwell, GL Tian, CQ Carlson, JW Ozols, RF Rose, PG Markman, M Armstrong, DK Muggia, F McGuire, WP AF Winter, William E., III Maxwell, G. Larry Tian, Chunqiao Carlson, Jay W. Ozols, Robert F. Rose, Peter G. Markman, Maurie Armstrong, Deborah K. Muggia, Franco McGuire, William P. TI Prognostic factors for stage III epithelial ovarian cancer: A Gynecologic Oncology Group Study SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID REPRODUCTIVE AGE-GROUP; HIGH-DOSE CARBOPLATIN; INTRAPERITONEAL CISPLATIN; SURGICAL CYTOREDUCTION; GROUP EXPERIENCE; CARCINOMA; SURVIVAL; WOMEN; PACLITAXEL; SURGERY AB Purpose Conflicting results on prognostic factors for advanced epithelial ovarian cancer ( EOC) have been reported because of small sample size and heterogeneity of study population. The purpose of this study was to identify factors predictive of poor prognosis in a similarly treated population of women with advanced EOC. Patients and Methods A retrospective review of demographic, pathologic, treatment, and outcome data from 1,895 patients with International Federation of Gynecology and Obstetrics stage III EOC who had undergone primary surgery followed by six cycles of intravenous platinum/paclitaxel was conducted. A proportional hazards model was used to assess the association of prognostic factors with progression-free survival ( PFS) and overall survival ( OS). Results Increasing age was associated with increased risks for disease progression ( HR = 1.06; 95% CI, 1.02 to 1.11 for an increase every 10 years) and death ( HR = 1.12; 95% CI, 1.06 to 1.18). Mucinous or clear-cell histology was associated with a worse PFS and OS compared with serous carcinomas. Patients with performance status ( PS) 1 or 2 were at an increased risk for recurrence compared with PS 0 ( HR = 1.12; 95% CI, 1.01 to 1.24). Compared with patients with microscopic residual disease, patients with 0.1 to 1.0 cm and > 1.0 cm residual disease had an increased risk of recurrence ( HR = 1.96; 95% CI, 1.70 to 2.26; and HR = 2.36; 95% CI, 2.04 to 2.73, respectively) and death ( HR = 2.11; 95% CI, 1.78 to 2.49; P < .001; and HR = 2.47; 95% CI, 2.09 to 2.92, respectively). Conclusion Age, PS, tumor histology, and residual tumor volume were independent predictors of prognosis in patients with stage III EOC. These data can be used to identify patients with poor prognosis and to design future tailored randomized clinical trials. C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX USA. Univ Texas, MD Anderson Canc Ctr, Houston, TX USA. Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA. NYU Med Ctr, Kaplan Canc Ctr, Dept Med & Med Oncol, New York, NY USA. Gynecol Oncol W Michigan, Grand Rapids, MI USA. Fox Chase Canc Ctr, Med Sci, Philadelphia, PA 19111 USA. Case Western Reserve Univ, Cleveland Clin Fdn, Dept Obstet & Gynecol, Div Gynecol Oncol, Cleveland, OH 44106 USA. Johns Hopkins Kimmel Canc Ctr, Baltimore, MD USA. Harry & Jeannette Weinberg Canc Inst, Franklin Square Hosp Ctr, Baltimore, MD USA. RP Maxwell, GL (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. EM george.maxwell@na.amedd.army.mil OI Muggia, Franco/0000-0003-0703-9146 FU NCI NIH HHS [CA 27469, CA 37517] NR 39 TC 361 Z9 366 U1 1 U2 6 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD AUG 20 PY 2007 VL 25 IS 24 BP 3621 EP 3627 DI 10.1200/JCO.2006.10.2517 PG 7 WC Oncology SC Oncology GA 209VK UT WOS:000249415900013 PM 17704411 ER PT J AU Chu, QSC Schwartz, G de Bono, J Smith, DA Koch, KM Versola, MJ Pandite, L Arya, N Curtright, J Fleming, RA Ho, PTC Rowinsky, EK AF Chu, Quincy S. C. Schwartz, Garry de Bono, Johann Smith, Deborah A. Koch, Kevin M. Versola, Melissa J. Pandite, Lini Arya, Nikita Curtright, Jan Fleming, Ronald A. Ho, Peter T. C. Rowinsky, Eric K. TI Phase I and pharmacokinetic study of lapatinib in combination with capecitabine in patients with advanced solid malignancies SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article; Proceedings Paper CT 40th Annual Meeting of the American-Society-of-Clinical-Oncology CY JUN 05-08, 2004 CL New Orleans, LA SP Amer Soc Clin Oncol ID GROWTH-FACTOR RECEPTOR; CELL LUNG-CANCER; BREAST-CANCER; POOR-PROGNOSIS; OVARIAN-CANCER; NEU ONCOGENE; OVEREXPRESSION; AMPLIFICATION; INHIBITOR; EXPRESSION AB Purpose This phase I trial ( EGF10005) assessed the safety, optimally tolerated regimen ( OTR), and pharmacokinetics of lapatinib and capecitabine in combination in patients with advanced solid malignancies. Patients and Methods Patients with previously treated, advanced solid malignancies were eligible. Cohorts of at least three patients each received once- daily oral lapatinib ( continuous) and capecitabine ( twice daily for 14 days every 21 days). Doses of lapatinib and capecitabine were escalated based on dose- limiting toxicities in the first treatment cycle until the OTR was reached. Additional patients were treated at the OTR dose level to further evaluate safety and for pharmacokinetic analyses. Results Forty- five patients were treated in the study. The OTR was determined to be lapatinib 1,250 mg/ d plus capecitabine 2,000 mg/ m(2)/ d. The majority of drug- related adverse events were grade 1 to grade 2 in severity, with few grade 3 and no grade 4 toxicities. The most common drug- related toxicities ( > 15% of patients) were diarrhea, nausea, rash, palmar- plantar erythrodysesthesia, mucositis, vomiting, and stomatitis. There were four confirmed responses ( one complete response and three partial responses). The pharmacokinetics ( area under the curve and maximum concentration) of lapatinib, capecitabine and its metabolites, fluorouracil, and alpha- fluoro- beta- alanine, were not meaningfully altered by coadministration. Conclusion Lapatinib and capecitabine administered on a 3- week schedule were well tolerated, and no pharmacokinetic interaction was observed. Clinical activity was observed in patients with previously treated, advanced solid malignancies. C1 CHU, Edmonton, AB T6G 1Z2, Canada. Brooke Army Med Ctr, Canc Therapy & Res Ctr, Inst Drug Dev, San Antonio, TX USA. GlaxoSmithKline Inc, Res Triangle Pk, NC USA. RP Chu, QSC (reprint author), CHU, 11560 Univ Ave, Edmonton, AB T6G 1Z2, Canada. EM quincchu@cancerboard.ab.ca FU Medical Research Council [G0501019] NR 22 TC 36 Z9 36 U1 0 U2 2 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD AUG 20 PY 2007 VL 25 IS 24 BP 3753 EP 3758 DI 10.1200/JCO.2007.11.1765 PG 6 WC Oncology SC Oncology GA 209VK UT WOS:000249415900032 PM 17704424 ER PT J AU Whitman, EJ Brassell, SA Rosner, IL Moncur, JT AF Whitman, Eric J. Brassell, Stephen A. Rosner, Inger L. Moncur, Joel T. TI Merkel cell carcinoma as a solitary metastasis to the testis SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article C1 Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. RP Whitman, EJ (reprint author), Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD AUG 20 PY 2007 VL 25 IS 24 BP 3785 EP 3786 DI 10.1200/JCO.2007.12.3091 PG 3 WC Oncology SC Oncology GA 209VK UT WOS:000249415900038 PM 17704430 ER PT J AU Guzman-Cornejo, C Robbins, RG Perez, TM AF Guzman-Cornejo, Carmen Robbins, Richard G. Perez, Tila M. TI The Ixodes (Acari : Ixodidae) of Mexico: parasite-host and host-parasite checklists SO ZOOTAXA LA English DT Article DE Ixodidae; Ixodes; Mexico; checklists; hosts; distribution ID SCELOPORUS-OCCIDENTALIS; ABUNDANCE; NEUMANN; LIZARD AB Parasite-host and host- parasite checklists are provided for all species of Ixodes known from Mexico; host and locality data are from specimens housed in the Coleccion Nacional de Acaros, Instituto de Biologia, Universidad Nacional Autonoma de Mexico, and from literature. Six Ixodes species ( I. brunneus, I. conepati, I. dentatus, I. eadsi, I. guatemalensis, I. texanus) are newly recorded from Mexico; in addition, 17 new locality records are presented for eight species ( I. affinis, I. boliviensis, I. luciae, I. rubidus, I. scapularis, I. spinipalpis, I. tancitarius, I. woodi), and eight new host records are given for five species ( I. affinis, I. boliviensis, I. rubidus, I. spinipalpis, I. tancitarius). C1 Univ Nacl Autonoma Mexico, Inst Biol, Colecc Nacl Acaros, Mexico City 04510, DF, Mexico. Walter Reed Army Med Ctr, DPMIA AFPMB, Washington, DC 20307 USA. RP Guzman-Cornejo, C (reprint author), Univ Nacl Autonoma Mexico, Inst Biol, Colecc Nacl Acaros, 3 Circuito Exterior S-N,Ciudad Univ, Mexico City 04510, DF, Mexico. EM cguzman@ibiologia.unam.mx NR 42 TC 11 Z9 12 U1 0 U2 0 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD AUG 20 PY 2007 IS 1553 BP 47 EP 58 PG 12 WC Zoology SC Zoology GA 202ND UT WOS:000248908400002 ER PT J AU Andzelm, J Rawlett, AM Orlicki, JA Snyder, JF Baldridge, KK AF Andzelm, Jan Rawlett, Adam M. Orlicki, Joshua A. Snyder, James F. Baldridge, Kim K. TI PHYS 538-UV-Vis Spectra and RSA properties of phthalocyanine compounds SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Andzelm, Jan; Rawlett, Adam M.; Orlicki, Joshua A.; Snyder, James F.] USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [Baldridge, Kim K.] Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland. [Baldridge, Kim K.] San Diego Supercomp Ctr, CH-8057 Zurich, Switzerland. EM jandzelm@arl.army.mil; arawlett@arl.army.mil; jorlicki@arl.army.mil; jsnyder@arl.army.mil; kimb@oci.unizh.ch NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 538-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593907503 ER PT J AU Andzelm, J Beyer, FL Snyder, JF Chung, PW AF Andzelm, Jan Beyer, Frederick L. Snyder, James F. Chung, Peter W. TI Multiscale simulations of block copolymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Andzelm, Jan; Snyder, James F.] USA, Div Mat, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Beyer, Frederick L.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Chung, Peter W.] USA, Res Lab, AMSRD CI HC, Aberdeen, MD 21005 USA. EM jandzelm@arl.army.mil; flbeyer@arl.army.mil; jsnyder@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 96-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593906395 ER PT J AU Andzelm, J Sloan, JM Napadensky, E Crawford, DM AF Andzelm, Jan Sloan, James M. Napadensky, Eugene Crawford, Dawn M. TI Modeling of sulfonated triblock copolymers with metal ions SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Andzelm, Jan] USA, Div Mat, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Sloan, James M.; Napadensky, Eugene; Crawford, Dawn M.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jandzelm@arl.army.mil; enapade@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 441-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593906390 ER PT J AU Banks, HD AF Banks, Harold D. TI ORGN 450-Solvent and substituent effects in nucleophilic attack on small-ring nitrogen compounds SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Banks, Harold D.] US Army, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. EM harold.banks@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 450-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12JA UT WOS:000207594300135 ER PT J AU Bruno, F Fossey, SA Nagarajan, S Nagarajan, R Kumar, J Samuelson, LA AF Bruno, Ferdinando Fossey, Stephen A. Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Kumar, Jayant Samuelson, Lynne A. TI POLY 626-Biomimetic synthesis of water soluble conducting copolymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Bruno, Ferdinando] USA, Natick Soldier Ctr, RDECOM, Natick, MA 01760 USA. [Fossey, Stephen A.] USA, Mat Res Ctr, Natick, MA 01760 USA. [Nagarajan, Subhalakshmi; Nagarajan, Ramaswamy] Univ Massachusetts, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. [Kumar, Jayant] Univ Massachusetts, Dept Phys, Ctr Adv Mat, Lowell, MA 01854 USA. [Samuelson, Lynne A.] Univ Massachusetts, USA, Soldier & Biol Chem Command, Natick Soldier Ctr, Natick, MA 01760 USA. EM Ferdinando_Bruno@uml.edu; stephen.fossey@us.army.mil; mailtosubha@yahoo.com; ram@uml.edu; Jayant_Kumar@uml.edu; Lynne_Samuelson@uml.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 626-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593908149 ER PT J AU Bruno, F Nagarajan, S Nagarajan, R Kumar, J Samuelson, LA AF Bruno, Ferdinando Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Kumar, Jayant Samuelson, Lynne A. TI POLY 437-A novel template for the formation of water-soluble conducting polymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Bruno, Ferdinando; Samuelson, Lynne A.] USA, Natick Soldier Ctr, RDECOM, Natick, MA 01760 USA. [Nagarajan, Subhalakshmi; Nagarajan, Ramaswamy] Univ Massachusetts, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. [Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Ctr Adv Mat, Lowell, MA 01854 USA. EM Ferdinando_Bruno@uml.edu; mailtosubha@yahoo.com; ram@uml.edu; Jayant_Kumar@uml.edu; Lynne_Samuelson@uml.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 437-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593908151 ER PT J AU Doona, C Feeherry, F Kustin, K Curtin, MA Barcus, J AF Doona, Christopher Feeherry, Florence Kustin, Kenneth Curtin, Maria A. Barcus, Jennifer TI AGFD 160-Kinetics and mechanism of effector-driven oxyhalogen reactions for the inactivation of foodborne microorganisms by chlorine dioxide SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Doona, Christopher; Feeherry, Florence] USA, Natick Soldier RDEC, DoD Combat Feeding Program, Natick, MA 01760 USA. [Kustin, Kenneth] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA. [Curtin, Maria A.; Barcus, Jennifer] Stonehill Coll, Dept Chem, Easton, MA 02357 USA. EM christopher.doona@natick.army.mil; kmkustin@ix.netcom.com; mcurtin@stonehill.edu NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 160-AGFD PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593900260 ER PT J AU Glaspell, GP Anderson, JE El-Shall, SM AF Glaspell, Garry P., II Anderson, John E. El-Shall, Sammy M. TI PHYS 380-Tunable photoluminescence observed in semiconductor nanostructures SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Glaspell, Garry P., II; El-Shall, Sammy M.] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA. [Anderson, John E.] US Army, Erdc, Alexandria, VA 22315 USA. EM gglaspell@gmail.com; SELSHALL@HSC.VCU.EDU RI El-Shall, M. Samy/K-8954-2012 OI El-Shall, M. Samy/0000-0002-1013-4948 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 380-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593907657 ER PT J AU Hong, HP Wright, B Wang, XB Roy, W AF Hong, Haiping Wright, Brian Wang, Xuebin Roy, Walter TI Time dependent thermal conductivity in the polyalphaolefine (PAO) oils SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Hong, Haiping; Wright, Brian] S Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. [Wang, Xuebin] Pacific NW Natl Lab, EMSL, CS&D, Richland, WA 99352 USA. [Roy, Walter] USA, Res Lab, Washington, DC USA. EM Haiping.Hong@sdsmt.edu; xuebin.wang@pnl.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 557-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593905683 ER PT J AU Jiang, XH Kumar, K Wallqvist, A Reifman, J AF Jiang, Xiaohui Kumar, Kamal Wallqvist, Anders Reifman, Jaques TI COMP 235-DOVIS: A high performance computing tool for virtual screening using AutoDock SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Jiang, Xiaohui; Kumar, Kamal; Wallqvist, Anders; Reifman, Jaques] USA, Biotechnol HPC Software Applicat Inst, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM xjiang@bioanalysis.org NR 0 TC 0 Z9 0 U1 2 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 235-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593906180 ER PT J AU Lee, IC AF Lee, Ivan C. TI FUEL 118-Rhodium supported on thermally enhanced zeolite as catalysts fuel reformation of jet fuels SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Lee, Ivan C.] USA, Sensors & Elect Devices Directorate, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. EM ilee@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 118-FUEL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593903502 ER PT J AU Mather, BD Baker, MB Williams, SR Beyer, R Long, TE AF Mather, Brian D. Baker, Margaux B. Williams, Sharlene R. Beyer, Rick Long, Timothy E. TI Nanostructured block copolymers with inspiration from biology SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Mather, Brian D.; Baker, Margaux B.; Williams, Sharlene R.; Long, Timothy E.] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA. [Beyer, Rick] USA, Res Lab, Div Mat, AMSRD ARL MW MA, Aberdeen Proving Ground, MD 21005 USA. EM bmather@vt.edu; margauxb@umich.edu; flbeyer@arl.army.mil; telong@vt.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 156-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593905589 ER PT J AU McGarvey, D Creasy, WR Schreuder-Gibson, H Walker, J AF McGarvey, David Creasy, William R. Schreuder-Gibson, Heidi Walker, John TI GEOC 67-Evaluation of toxic chemical degradation rates on solid materials by P-31 and C-13 NMR SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [McGarvey, David; Creasy, William R.] SAIC, Aberdeen Proving Ground, MD 21010 USA. [Schreuder-Gibson, Heidi] USA, Res Dev & Engn Command Natick, AMSRD NSC WS M, Natick, MA 01760 USA. [Walker, John] USA, Natick Soldier Ctr, Dept Army, US Soldier Chem Biol Command, Natick, MA 01760 USA. EM davidmcgarvey@yahoo.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 67-GEOC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902825 ER PT J AU Murphy, DQ Zukas, W Mead, JL AF Murphy, Daniel Q. Zukas, Walter Mead, Joey L. TI COLL 402-Surface functionalization of butyl rubber electrospun membranes: Applications in chemical protection SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Murphy, Daniel Q.; Mead, Joey L.] Univ Massachusetts Lowell, Dept Plast Engn, Lowell, MA 01854 USA. [Zukas, Walter] USA, NSRDEC, Natick, MA 01760 USA. [Mead, Joey L.] Univ Massachusetts Lowell, Ctr High Rate Nanomfg, Lowell, MA 01854 USA. EM daniel_murphy@student.uml.edu; walter.zukas@natick.army.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 402-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902445 ER PT J AU Nagarajan, S Nagarajan, R Bruno, FF Samuelson, LA Kumar, J AF Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Bruno, Ferdinando F. Samuelson, Lynne A. Kumar, Jayant TI POLY 486-Stable biomimetic redox catalyst obtained by enzyme catalyzed amidation of Iron porphyrin SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Nagarajan, Subhalakshmi] Univ Massachusetts, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. [Nagarajan, Ramaswamy] Univ Massachusetts Lowell, Dept Plast Engn, Ctr Adv Mat, Lowell, MA 01854 USA. [Bruno, Ferdinando F.; Samuelson, Lynne A.] USA, Natick Soldier Ctr, RDECOM, Natick, MA 01760 USA. [Kumar, Jayant] Univ Massachusetts, Dept Phys, Ctr Adv Mat, Lowell, MA 01854 USA. EM mailtosubha@yahoo.com; Ramaswamy_Nagarajan@uml.edu; Ferdinando_bruno@uml.edu; Lynne_Samuelson@uml.edu; Jayant_Kumar@uml.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 486-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593908589 ER PT J AU Onischak, M Sishtla, C Brown, C Dueck, J Holcomb, FH AF Onischak, Michael Sishtla, Chakravarthy Brown, Casey Dueck, Jason Holcomb, Franklin H. TI JP8 fueled SOFC power system SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Onischak, Michael; Sishtla, Chakravarthy] Inst Gas Technol, Des Plaines, IL 60018 USA. [Brown, Casey; Dueck, Jason] Versa Power Syst, Calgary, AB T2B 3R2, Canada. [Holcomb, Franklin H.] USA, ERDC CERL, Champaign, IL 61822 USA. EM mike.onischak@gastechnology.org; chuck.sishtla@gastechnology.org; casey.brown@versa-power.com; jason.dueck@versa-power.com; Franklin.H.Holcomb@erdc.usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 54-FUEL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593903488 ER PT J AU Orlicki, JA Rawlett, AM Zander, NE La Scala, JJ Kosik, WE Smith, P Andrews, K AF Orlicki, Joshua A. Rawlett, Adam M. Zander, Nicole E. La Scala, John J. Kosik, W. E. Smith, Pauline Andrews, Kevin TI COLL 400-Nanoengineered additives with self-stratifying characteristics: A novel approach to improve CBD technologies SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Orlicki, Joshua A.; Rawlett, Adam M.; Zander, Nicole E.; Kosik, W. E.] USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [La Scala, John J.; Smith, Pauline; Andrews, Kevin] USA, Res Lab, Div Mat, Mat Applicat Branch, Aberdeen Proving Ground, MD 21005 USA. EM jorlicki@arl.army.mil; arawlett@arl.army.mil; nzander@arl.army.mil; jlascala@arl.army.mil; pmsmith@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 400-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902327 ER PT J AU Peterson, GW Karwacki, CJ Feaver, WB Rossin, JA AF Peterson, Grewory W. Karwacki, Christopher J. Feaver, William B. Rossin, Joseph A. TI COLL 322-Pore size modification of zeolite ZSM-5 for enhanced ethylene oxide filtration SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Peterson, Grewory W.; Karwacki, Christopher J.] USA, ECBC, Aberdeen Proving Ground, MD 21010 USA. [Feaver, William B.; Rossin, Joseph A.] Guild Associates Inc, Dublin, OH 43016 USA. EM gregory.w.peterson@us.army.mil; christopher.karwacki@us.army.mil; billfeaver@guildassociates.com; jarossin@guildassociates.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 322-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902300 ER PT J AU Runner, RR Shapiro, BA McPherson, JC Buxton, TB AF Runner, Royce R. Shapiro, Brian A. McPherson, James C., III Buxton, Thomas B. TI MEDI 413-Targeted drug-delivery of an antibiotic bound to nanosized hydroxyapatite bone particles for treatment of bone injury SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Runner, Royce R.; Shapiro, Brian A.; Buxton, Thomas B.] Geneva Fdn, Dept Clin Invest, Ft Gordon, GA 30905 USA. [McPherson, James C., III] Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. EM royce.runner@amedd.army.mil; james.mcpherson@amedd.army.mil; thomas.buxton@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 413-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593906634 ER PT J AU Saito, T Mather, BD Beyer, FL Long, TE AF Saito, Tomonori Mather, Brian D. Beyer, Frederick L. Long, Timothy E. TI Influence of selective sulfonation on acrylic graft copolymer morphology SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Saito, Tomonori; Mather, Brian D.; Long, Timothy E.] Virginia Tech, Dept Chem, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA. [Beyer, Frederick L.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM tsaito@vt.edu; bmather@vt.edu; flbeyer@arl.army.mil; telong@vt.edu RI Saito, Tomonori/M-1735-2016 OI Saito, Tomonori/0000-0002-4536-7530 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 384-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593905791 ER PT J AU Schreuder-Gibson, HL Walker, JE Yeomans, W Carlson, J Orlicki, JA Ball, D AF Schreuder-Gibson, Heidi L. Walker, John E. Yeomans, Walter Carlson, Joel Orlicki, Joshua A. Ball, Derek TI Reactivity of polyoxometalate catalysts in fibers, films and carbon substrates SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Schreuder-Gibson, Heidi L.; Walker, John E.; Ball, Derek] USA, Macromol Sci Team, Natick Soldier Res Dev & Engn Ctr, AMSRD NSC WS M, Natick, MA 01760 USA. [Yeomans, Walter] USA, Combat Feeding Directorate, Natick Soldier Res Dev & Engn Ctr, AMSRD NSC CF, Natick, MA 01760 USA. [Carlson, Joel] USA, Nanomat Sci Team, Natick Soldier Res Dev & Engn Ctr, AMSRD NSC WS N, Natick, MA 01760 USA. [Orlicki, Joshua A.] USA, Div Mat, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM heidi.schreudergibson@us.army.mil; jorlicki@arl.army.mil NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 842-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593909345 ER PT J AU Senecal, KJ Marek, P Magnone, J Senecal, A AF Senecal, Kris J. Marek, Patrick Magnone, Joshua Senecal, Andre TI COLL 475-Development of multiplexed nanofiborous membranes for capture of Chem/Bio agents from complex materials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Senecal, Kris J.] USA, Natick Soldier Res Dev Engn Ctr, Macromol Sci Team, Natick, MA 01760 USA. [Marek, Patrick; Magnone, Joshua; Senecal, Andre] USA, Natick Soldier Res Dev & Engn Ctr, Performance Enhancement & Food Safety Team, Natick, MA 01760 USA. EM Kris.Senecal@natick.army.mil; patrick.marek@natick.army.mil; joshua.magnone@natick.army.mil; andy.senecal@natick.army.mil RI Senecal, Kris/F-3000-2013 NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 475-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902121 ER PT J AU Smith, CB Anderson, JE Tatineni, B AF Smith, Clint B. Anderson, John E. Tatineni, Balaji TI Surface imprinted silica nanoparticles for FRET based detection of methyl salicylate SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Smith, Clint B.; Anderson, John E.] USA, Erdc, Alexandria, VA 22315 USA. [Tatineni, Balaji] Virginia Commonwelath Univ, Dept Chem, Rchmond, VA 23284 USA. EM clint.b.smith@erdc.usace.army.mil; btatineni@vcu.edu NR 0 TC 0 Z9 0 U1 1 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 208-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902097 ER PT J AU Sooter, LJ Stratis-Cullum, DN Zhang, YT Daugherty, PS Soh, HT Pellegrino, P Stagliano, N AF Sooter, Letha J. Stratis-Cullum, Dimitra N. Zhang, Yanting Daugherty, Patrick S. Soh, H. Tom Pellegrino, Paul Stagliano, Nancy TI COLL 31-Rapid immunochromatographic biowarfare detection using affinity reagents from microfluidic in vitro selections SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Sooter, Letha J.] USA, Res Lab ORAU, AMSRD ARL SE EO, Adelphi, MD 20783 USA. [Zhang, Yanting; Stagliano, Nancy] CytomX LLC, Santa Barbara, CA 93105 USA. [Daugherty, Patrick S.] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Soh, H. Tom] Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA. [Soh, H. Tom] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. [Pellegrino, Paul] USA, Res Lab, Opt Branch, AMSRD ARL SE EO, Adelphi, MD 20783 USA. EM letha.sooter@arl.army.mil NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 31-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902037 ER PT J AU Stanley, JK Brooks, BW AF Stanley, Jacob K. Brooks, Bryan W. TI AGRO 139-Importance of enantioselectivity in fate and effects to ecological hazard assessment of chiral contaminants SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Stanley, Jacob K.] Baylor Univ, CRASR, Waco, TX 76798 USA. [Stanley, Jacob K.] US Army Corps Engn, ERDC, Waco, TX 76798 USA. [Brooks, Bryan W.] Baylor Univ, Dept Environm Studies, Waco, TX 76798 USA. EM jacob_stanley@baylor.edu; bryan_brooks@baylor.edu RI Guenat, Heather/H-6528-2014 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 139-AGRO PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593900474 ER PT J AU Steeves, DM Soares, JW AF Steeves, Diane M. Soares, Jason W. TI COLL 476-Role of surface modifier structure on the optical behavior of biofunctionalized nanocrystalline-ZnO SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Steeves, Diane M.] USA, Natick Soldier Res Dev & Engn Ctr, Nanomat Team WarSTAR, Natick, MA 01760 USA. [Soares, Jason W.] USA, Natick Soldier Res Dev & Engn Ctr, MST WarSTAR, Natick, MA 01760 USA. EM Diane.Steeves@us.army.mil; jason.soares@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 476-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902517 ER PT J AU Viswanathan, S Kinlen, P Landy, D Ebron, V Hou, SF Ulyanova, J Bashkin, J Koeller, K Durham, P Vause, C Li, J Collin, T Horwitz, C McAdams, J Hampel, J Walker, J AF Viswanathan, Sriram Kinlen, Patrick Landy, Donald Ebron, Von Hou, Shifeng Ulyanova, Jenny Bashkin, James Koeller, Kevin Durham, Paul Vause, Carrie Li, Jing Collin, Terrence Horwitz, Colin McAdams, Julia Hampel, Jean Walker, John TI COLL 438-Self-detoxifying polymer system for chemical and biological warfare agents SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Viswanathan, Sriram; Kinlen, Patrick; Landy, Donald; Ebron, Von; Hou, Shifeng; Ulyanova, Jenny] Crosslink USA, St Louis, MO 63026 USA. [Bashkin, James; Koeller, Kevin] NanoVir, St Louis, MO USA. [Durham, Paul; Vause, Carrie; Li, Jing] Missouri State Univ, Ctr Biol & Life Sci, Springfield, MO 65897 USA. [Collin, Terrence; Horwitz, Colin] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [McAdams, Julia; Hampel, Jean; Walker, John] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 438-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902155 ER PT J AU Walker, J Schreuder-Gibson, H Yeomans, W Ball, D Hill, C AF Walker, John Schreuder-Gibson, Heidi Yeomans, Walter Ball, Derek Hill, Craig TI INOR 695-Catalytic reactivity of polyoxometalatetes adsorbed in microporous carbons SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Ball, Derek] USA, Natick Soldier Res Dev & Engn Ctr, Macromol Sci Team, AMSRD NSC WS M, Natick, MA 01760 USA. [Schreuder-Gibson, Heidi] USA, Natick Soldier Ctr, Res Dev & Engn Command, AMSRD NSC SS MS, Natick, MA 01760 USA. [Yeomans, Walter] USA, Soldier Syst Ctr, AMSSB RSS MS, Natick, MA 01760 USA. [Hill, Craig] Emory Univ, Dept Chem, Atlanta, GA 30329 USA. EM John.e.Walker1@us.army.mil; heidi.schreudergibson@us.army.mil; derekhball@aol.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 695-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593909109 ER PT J AU Wilusz, E AF Wilusz, Eugene TI COLL 398-Membrane development for lightweight, chemical biological protection SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Wilusz, Eugene] USA, Natick Soldier Res Dev & Engn Ctr, ATTN AMSRD NSC WS MT, Natick, MA 01760 USA. EM eugene.wilusz@natick.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 19 PY 2007 VL 234 MA 398-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V12IW UT WOS:000207593902523 ER PT J AU DeJonge, KC Kaleita, AL Thorp, KR AF DeJonge, Kendall C. Kaleita, Amy L. Thorp, Kelly R. TI Simulating the effects of spatially variable irrigation on corn yields, costs, and revenue in Iowa SO AGRICULTURAL WATER MANAGEMENT LA English DT Article DE CERES-Maize; precision agriculture; water use; economics; available soil water ID CERES-MAIZE MODEL; GREAT-PLAINS; WATER; MANAGEMENT; CROP; OPTIMIZATION; NITROGEN; STRESS; SOILS AB In this study, the CERES-Maize crop model was used in conjunction with Apollo, a shell program, to evaluate potential improved yield in a central Iowa cornfield on a spatially and temporally variable basis. Five years of historical yield and weather data were used to calibrate the model over 100 spatially variable grid cells for non-irrigated conditions in the 20.25 ha field. This calibrated model then used 28 years of historical weather data to simulate three irrigation scenarios: no irrigation, scheduled uniform irrigation, and precision irrigation. Irrigation improved yield by at least 500 kg ha(-1) in half of the years simulated. Precision irrigation showed slightly lower yields than scheduled uniform irrigation. Assuming use of a center pivot system, irrigation showed economic returns in only one of the 28 years included in the study. High capital costs were the leading restrictor of economic feasibility. (c) 2007 Elsevier B.V. All rights reserved. C1 Iowa State Univ Sci & Technol, Dept Agr & Biosyst Engn, Ames, IA 50011 USA. US Army Corps Engn, Hydrol Engn Branch, Omaha, NE 68102 USA. US Arid Land Agr Res Ctr, Maricopa, AZ 85239 USA. RP Kaleita, AL (reprint author), Iowa State Univ Sci & Technol, Dept Agr & Biosyst Engn, Ames, IA 50011 USA. EM kaleita@iastate.edu RI Thorp, Kelly/C-2013-2009; Kaleita, Amy/J-8363-2016 OI Thorp, Kelly/0000-0001-9168-875X; Kaleita, Amy/0000-0002-8906-3408 NR 40 TC 16 Z9 17 U1 1 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3774 J9 AGR WATER MANAGE JI Agric. Water Manage. PD AUG 16 PY 2007 VL 92 IS 1-2 BP 99 EP 109 DI 10.1016/j.agwat.2007.05.008 PG 11 WC Agronomy; Water Resources SC Agriculture; Water Resources GA 202TN UT WOS:000248926800011 ER PT J AU Johnson, EN Burns, TC Hayda, RA Hospenthal, DR Murray, CK AF Johnson, Erica N. Burns, Travis C. Hayda, Roman A. Hospenthal, Duane R. Murray, Clinton K. TI Infectious complications of open type III tibial fractures among combat casualties SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID OPERATION-ENDURING-FREEDOM; SURGICAL-TEAM; WAR WOUNDS; MANAGEMENT; NONUNION; SINGLE AB Background. Combat is associated with high-energy explosive injuries, often resulting in open tibial fractures complicated by nonunion and infection. We characterize the infections seen in conjunction with combat-associated type III tibial fractures. Methods. We performed a retrospective medical records review to identify US military service members wounded in Iraq or Afghanistan with open diaphyseal tibial fractures who were admitted to our facility (Brooke Army Medical Center, Fort Sam Houston, Texas) between March 2003 and September 2006. Results. Of the 62 patients with open tibial fractures who were identified in our initial search, 40 had fractures that met our inclusion criteria as type III diaphyseal tibial fractures. Three patients were excluded because their fractures were managed with early limb amputation, and 2 were excluded because of incomplete follow-up records. Twenty-seven of these 35 patients had at least 1 organism present in initial deep-wound cultures that were performed at admission to the hospital. The pathogens that were identified most frequently were Acinetobacter, Enterobacter species, and Pseudomonas aeruginosa. Thirteen of the 35 patients had union times of 19 months that appeared to be associated with infection. None of the gram-negative bacteria identified in the initial wound cultures were recovered again at the time of a second operation; however, all patients had at least 1 staphylococcal organism. One patient had an organism present during initial culture and in the nonunion wound; this organisim was a methicillin-resistant Staphylococcus aureus strain that was inadvertently not treated. Five of 35 patients ultimately required limb amputation, with infectious complications cited as the reason for amputation in 4 of these cases. Conclusions. Combat-associated type III tibial fractures are predominantly associated with infections due to gram-negative organisms, and these infections are generally successfully treated. Recurrent infections are predominantly due to staphylococci. C1 Brooke Army Med Ctr, Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Med, Infect Dis Serv, Houston, TX USA. Brooke Army Med Ctr, Dept Orthoped Surg, Houston, TX USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil NR 21 TC 123 Z9 128 U1 3 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG 15 PY 2007 VL 45 IS 4 BP 409 EP 415 DI 10.1086/520029 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 190SK UT WOS:000248079500001 PM 17638186 ER PT J AU Jobe, O Lumsden, J Mueller, AK Williams, J Silva-Rivera, H Kappe, SHI Schwenk, RJ Matuschewski, K Krzych, U AF Jobe, Ousman Lumsden, Joanne Mueller, Ann-Kristin Williams, Jackie Silva-Rivera, Hilda Kappe, Stefan H. I. Schwenk, Robert J. Matuschewski, Kai Krzych, Urszula TI Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex class I-dependent interferon-gamma-producing CD8(+) T cells SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IRRADIATED SPOROZOITES; CIRCUMSPOROZOITE PROTEIN; FALCIPARUM SPOROZOITES; MALARIA SPOROZOITES; VACCINE DEVELOPMENT; IMMUNITY; RESPONSES; IMMUNIZATION; LYMPHOCYTES; ANTIBODIES AB At present, radiation-attenuated plasmodia sporozoites (gamma-spz) is the only vaccine that induces sterile and lasting protection in malaria-naive humans and laboratory rodents. However, gamma-spz are not without risks. For example, the heterogeneity of the gamma-spz could explain occasional breakthrough infections. To avoid this possibility, we constructed a double-knockout P. berghei parasite by removing 2 genes, UIS3 and UIS4, that are up-regulated in infective spz. We evaluated the double-knockout Pbuis3(-)/4(-) parasites for protective efficacy and the contribution of CD8(+) T cells to protection. Pbuis3(-)/4(-) spz induced sterile and protracted protection in C57BL/6 mice. Protection was linked to CD8(+) T cells, given that mice deficient in beta(2)m were not protected. Pbuis3(-)/4(-) spz-immune CD8(+) T cells consisted of effector/memory phenotypes and produced interferon-gamma. On the basis of these observations, we propose that the development of genetically attenuated P. falciparum parasites is warranted for tests in clinical trials as a pre-erythrocytic stage vaccine candidate. C1 Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. Seattle Biomed Res Inst, Seattle, WA 98109 USA. Univ Heidelberg, Sch Med, Dept Parasitol, D-6900 Heidelberg, Germany. RP Krzych, U (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Urszula.Krzych@na.amedd.army.mil RI Lumsden, Joanne/B-6475-2009 FU NIAID NIH HHS [R01 AI046438, R01 AI046438-09, AI43411] NR 28 TC 88 Z9 93 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 15 PY 2007 VL 196 IS 4 BP 599 EP 607 DI 10.1086/519743 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 190DD UT WOS:000248037300017 PM 17624847 ER PT J AU Swenson, DP Ambrose, RF AF Swenson, Daniel P. Ambrose, Richard F. TI A spatial analysis of cumulative habitat loss in Southern California under the Clean Water Act Section 404 program SO LANDSCAPE AND URBAN PLANNING LA English DT Article DE development; GIS; permits; remote sensing; spatial autocorrelation; wetlands ID UNITED-STATES; LANDSCAPE; IMPACTS; URBANIZATION; CORRIDORS; STREAMS; SCALES; DEGRADATION; MITIGATION; WETLANDS AB Habitat loss is the leading cause of biodiversity reduction in the world today, with wetlands having experienced especially large losses in the United States and elsewhere. Using remote sensing and GIS techniques, this study quantified cumulative habitat loss in two Southern California watersheds associated with Clean Water Act Section 404 permits, primarily for developments, issued by the U.S. Army Corps of Engineers from 1984 to 2002. While the majority of habitat loss occurred outside of explicitly 404-authorized developments, non-explicitly authorized development represented a substantial fraction of observed habitat loss. The spatial distribution of habitat loss and 404 permits were analyzed statistically. In almost all cases, percent habitat loss was significantly correlated with variables representing 404 authorizations. These correlations may indicate the presence of incidental authorizations, suggesting that 404 authorizations within the study area may have indirectly facilitated nearby development (i.e., growth-inducing impacts). This study expanded the use of remote sensing, GIs, and spatial statistics for the purpose of regulatory-driven cumulative impact assessment. Until resource agencies quantify cumulative impacts in a spatially explicit manner and analyze those data statistically, there can be little rigorous scientific basis for formulating regulatory or policy decisions regarding cumulative impacts. (c) 2007 Elsevier B.V. All rights reserved. C1 USA, Corps Engineers, Regulatory Branch, Los Angeles, CA 90053 USA. Univ Calif Los Angeles, Dept Environm Hlth Sci, Environm Sci & Engn Program, Los Angeles, CA 90095 USA. RP Swenson, DP (reprint author), USA, Corps Engineers, Regulatory Branch, POB 532711, Los Angeles, CA 90053 USA. EM daniel.p.swenson@usace.army.mil; rambrose@ucla.edu OI Ambrose, Richard/0000-0001-8653-6487 NR 50 TC 2 Z9 3 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-2046 J9 LANDSCAPE URBAN PLAN JI Landsc. Urban Plan. PD AUG 15 PY 2007 VL 82 IS 1-2 BP 41 EP 55 DI 10.1016/j.landurbplan.2007.01.019 PG 15 WC Ecology; Environmental Studies; Geography; Geography, Physical; Urban Studies SC Environmental Sciences & Ecology; Geography; Physical Geography; Urban Studies GA 202UJ UT WOS:000248929000005 ER PT J AU Pando, MA Eyzaguirre, LM Carrion, G Montano, SM Sanchez, JL Carr, JK Avila, MM AF Pando, Maria A. Eyzaguirre, Lindsay M. Carrion, Gladys Montano, Silvia M. Sanchez, Jose L. Carr, Jean K. Avila, Maria M. TI High genetic variability of HIV-1 in female sex workers from Argentina SO RETROVIROLOGY LA English DT Article ID DRUG-NAIVE PATIENTS; BF RECOMBINANTS; SOUTH-AMERICA; SUBTYPE-C; TYPE-1; RESISTANCE; SEQUENCE AB Background: A cross-sectional study on 625 Female Sex Workers ( FSWs) was conducted between 2000 and 2002 in 6 cities in Argentina. This study describes the genetic diversity and the resistance profile of the HIV-infected subjects. Results: Seventeen samples from HIV positive FSWs were genotyped by env HMA, showing the presence of 9 subtype F, 6 subtype B and 2 subtype C. Sequence analysis of the protease/RT region on 16 of these showed that 10 were BF recombinants, three were subtype B, two were subtype C, and one sample presented a dual infection with subtype B and a BF recombinant. Full-length genomes of five of the protease/RT BF recombinants were also sequenced, showing that three of them were CRF12_BF. One FSW had a dual HIV-1 infection with subtype B and a BF recombinant. The B sections of the BF recombinant clustered closely with the pure B sequence isolated from the same patient. Major resistance mutations to antiretroviral drugs were found in 3 of 16 ( 18.8%) strains. Conclusion: The genetic diversity of HIV strains among FSWs in Argentina was extensive; about three-quarters of the samples were infected with diverse BF recombinants, near twenty percent had primary ART resistance and one sample presented a dual infection. Heterosexual transmission of genetically diverse, drug resistant strains among FSWs and their clients represents an important and underestimated threat, in Argentina. C1 Univ Buenos Aires, Fac Med, Dept Microbiol Immunol & Parasitol, Ctr Nacl Referencia SIDA, Buenos Aires, DF, Argentina. Univ Maryland, Inst Biotechnol, Dept Epidemiol, Inst Human Virol, Baltimore, MD 21201 USA. US Naval Med Res Ctr Dev, Lima, Peru. Walter Reed Army Inst Res, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina. RP Pando, MA (reprint author), Univ Buenos Aires, Fac Med, Dept Microbiol Immunol & Parasitol, Ctr Nacl Referencia SIDA, Paraguay 2155,Piso 11,C1121ABG, Buenos Aires, DF, Argentina. EM mpando@fmed.uba.ar; eyzaguir@umbi.umd.edu; gcarrion@nmrcd.med.navy.mil; smontano@nmrcd.med.navy.mil; Jose.Sanchez3@amedd.army.mil; carrj@umbi.umd.edu; mavila@fmed.uba.ar NR 23 TC 12 Z9 12 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD AUG 13 PY 2007 VL 4 AR 58 DI 10.1186/1742-4690-4-58 PG 9 WC Virology SC Virology GA 208CY UT WOS:000249298600001 PM 17697319 ER PT J AU Miura, K Keister, DB Muratova, OV Sattabongkot, J Long, CA Saul, A AF Miura, Kazutoyo Keister, David B. Muratova, Olga V. Sattabongkot, Jetsumon Long, Carole A. Saul, Allan TI Transmission-blocking activity induced by malaria vaccine candidates Pfs25/Pvs25 is a direct and predictable function of antibody titer SO MALARIA JOURNAL LA English DT Article ID IMMUNOSTIMULATORY DNA-SEQUENCES; MEROZOITE SURFACE PROTEIN-1; RANDOMIZED CONTROLLED-TRIAL; PLASMODIUM-FALCIPARUM; SEXUAL STAGE; GAMBIAN CHILDREN; CLINICAL-TRIALS; ANTIGEN PFS25; CPG MOTIFS; PHASE-I AB Background: Mosquito stage malaria vaccines are designed to induce an immune response in the human host that will block the parasite's growth in the mosquito and consequently block transmission of the parasite. A mosquito membrane-feeding assay ( MFA) is used to test transmission-blocking activity ( TBA), but in this technique cannot accommodate many samples. A clear understanding of the relationship between antibody levels and TBA may allow ELISA determinations to be used to predict TBA and assist in planning vaccine development. Methods: Rabbit anti-Pfs25 sera and monkey anti-Pvs25 sera were generated and the antibody titers were determined by a standardized ELISA. The biological activity of the same sera was tested by MFA using Plasmodium gametocytes ( cultured Plasmodium falciparum or Plasmodium vivax from malaria patients) and Anopheles mosquitoes. Results: Anti-Pfs25 and anti-Pvs25 sera showed that ELISA antibody units correlate with the percent reduction in the oocyst density per mosquito ( Spearman Rank correlations: 0.934 and 0.616, respectively), and fit a hyperbolic curve when percent reduction in oocyst density is plotted against antibody units of the tested sample. Antibody levels also correlated with the number of mosquitoes that failed to become infected, and this proportion can be calculated from the reduction in oocyst numbers and the distribution of oocysts per infected mosquito in control group. Conclusion: ELISA data may be used as a surrogate for the MFA to evaluate transmission-blocking vaccine efficacy. This will facilitate the evaluation of transmission-blocking vaccines and implementation of this malaria control strategy. C1 NIAID, Malaria Vaccine Dev Branch, NIH, Bethesda, MD 20892 USA. USA Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand. RP Miura, K (reprint author), NIAID, Malaria Vaccine Dev Branch, NIH, Bethesda, MD 20892 USA. EM kmiura@niaid.nih.gov; dkeister@niaid.nih.gov; omuratova@niaid.nih.gov; JetsumonP@afrims.org; clong@niaid.nih.gov; asaul@niaid.nih.gov RI Saul, Allan/I-6968-2013 OI Saul, Allan/0000-0003-0665-4091 FU Intramural NIH HHS NR 49 TC 39 Z9 44 U1 3 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD AUG 8 PY 2007 VL 6 AR 107 DI 10.1186/1475-2875-6-107 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 208DT UT WOS:000249300700002 PM 17686163 ER PT J AU Zhao, P Woolard, D AF Zhao, Peiji Woolard, Dwight TI Electrostatic characteristics of tether atoms in connecting organic molecules to the surface of silicon SO APPLIED PHYSICS LETTERS LA English DT Article ID POLYCYCLIC AROMATIC MOLECULE; TRANSITION-METAL-COMPLEXES; AB-INITIO; SI(100) SURFACE; MONOLAYERS; ADSORPTION; ATTACHMENT; LINKAGE; SI(001); STATES AB In this letter, the authors analyze the electrostatic characteristics of the tether atoms connecting organic molecules onto silicon (100)-2x1 surfaces, which is a key factor in the design of molecular devices for information processing and biomolecular sensing. Design principles for silicon surfaces with required electrostatic functionality are presented. C1 N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. USA, Res Off, Army Res Lab, Res Triangle Pk, NC 27709 USA. RP Zhao, P (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM pzhao@unity.ncsu.edu NR 24 TC 5 Z9 5 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 6 PY 2007 VL 91 IS 6 AR 063104 DI 10.1063/1.2766670 PG 3 WC Physics, Applied SC Physics GA 198XS UT WOS:000248661400110 ER PT J AU Ruffing, JA Nieves, JW Zion, M Tendy, S Garrett, P Lindsay, R Cosman, F AF Ruffing, Jamie A. Nieves, Jeri W. Zion, Marsha Tendy, Susan Garrett, Patricia Lindsay, Robert Cosman, Felicia TI The influence of lifestyle, menstrual function and oral contraceptive use on bone mass and size in female military cadets SO NUTRITION & METABOLISM LA English DT Article ID ADOLESCENT GIRLS; BODY-COMPOSITION; MINERAL DENSITY; YOUNG MEN; WOMEN; EXERCISE; DETERMINANTS; STRENGTH; ASSOCIATION; COHORT AB Purpose: To determine the influence of menstrual irregularity, oral contraceptive use and other factors on bone mineral density (BMD) and bone size at different skeletal sites in 135 college-aged fit women. Methods: Menstrual history, oral contraceptive use, exercise history, and nutritional factors including calcium, caffeine, and alcohol intake as well as tobacco use were determined by written survey. Height, weight and fitness levels were measured. Spine and hip BMD were measured by dual x-ray absorptiometry (DXA), calcaneus BMD by peripheral DXA, and tibial bone mineral content (BMC) and size by peripheral Quantitative Computed Tomography (pQCT). Results: The mean age was 18.4 +/- 0.8 years. Weight and prior exercise were positively related to BMD at most skeletal sites and to tibial bone size. Milk intake was positively related to calcaneal BMD, tibial BMC and cortical thickness. Fracture history was an important predictor of spine, hip and heel BMD. Women who had >= 10 menstrual cycles in the year prior to BMD measurement had higher BMD at all sites as well as a greater tibial mineral content and cortical thickness than women who had oligomenorrhea/amenorrhea (<= 9 cycles in the prior year; all p < 0.05). Oral Contraceptive (OC) users had significantly lower BMD in the spine (p < 0.02) and calcaneus (p = 0.04), smaller tibial periosteal circumference and lower tibial mineral content (p < 0.02) than non-OC users. Conclusion: In a population of fit, college-aged women, OC use and oligomenorrhea were associated with reduced BMD and bone size. Weight, as well as prior exercise and milk intake was positively related to bone density and size at some skeletal sites. Understanding these relationships would help improve skeletal health in young women. C1 Helen Hayes Hosp, Clin Res & Reg Bone Ctr, W Haverstraw, NY 10993 USA. Columbia Univ, Dept Med & Epidemiol, Coll Phys & Surg, New York, NY USA. US Mil Acad, West Point, NY 10996 USA. RP Nieves, JW (reprint author), Helen Hayes Hosp, Clin Res & Reg Bone Ctr, W Haverstraw, NY 10993 USA. EM ruffingj@aol.com; nievesj@helenhayeshosp.org; zionm@helenhayeshosp.org; sue.tendy@usma.edu; garrettp@helenhayeshosp.org; lindsayr@helenhayeshosp.org; cosmanf@helenhayeshosp.org NR 28 TC 11 Z9 11 U1 1 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1743-7075 J9 NUTR METABOLISM JI Nutr. Metab. PD AUG 6 PY 2007 VL 4 AR 17 DI 10.1186/1743-7075-4-17 PG 10 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 218EX UT WOS:000249999900001 PM 17683610 ER PT J AU Williams, JB Jauch, EC Lindsell, CJ Campos, B AF Williams, Justin B. Jauch, Edward C. Lindsell, Christopher J. Campos, Begona TI Endothelial microparticle levels are similar in acute ischemic stroke and stroke mimics due to activation and not apoptosis/necrosis SO ACADEMIC EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT SAEM Annual Meeting 2006 CY MAY, 2006 CL San Francisco, CA SP SAEM DE ischemic stroke; endothelial cells; CD31 antigen; PECAM-1; CD42b antigen; CD62e antigen; E-selectin ID ACUTE CORONARY SYNDROMES; MEMBRANE MICROPARTICLES; CELLS; DYSFUNCTION; DISEASE; MARKERS; LESIONS AB Background: Endothelial microparticles (EMPs) are <2-mu m membranous blebs from endothelial cell membranes that have been demonstrated to be elevated in vasculopathic conditions. One study has demonstrated elevated EMPs in acute ischemic stroke (AIS) versus age- and comorbidity-matched controls. Objectives: To determine the level of EMPs in stroke mimics and AIS and determine if EMPs are released as a result of activation or apoptosis/necrosis in AIS. Methods: EMP levels in plasma of patients with AIS and stroke mimic patients were quantified by flow cytometry. Stroke status was verified in all patients by magnetic resonance imaging. Patients were matched for age and comorbidities. Markers for apoptosis/necrosis (platelet/endothelial cell adhesion molecule-1 [PECAM-1]/CD31 antigen) and activation (E-selectin/CD62e antigen) were compared. A PECAM-1/E-selectin ratio of >4.0 was used to determine whether EMPs were generated via activation or apoptosis/necrosis. Data were compared between groups using the Mann-Whitney U test. Results: EMP levels were similar in stroke mimic patients when compared with AIS; there was no difference between groups (PECAM-1, p = 0.393; E-selectin, p = 0.579). The PECAM-1/E-selectin ratio was also similar for AIS and stroke mimics, and all were >4.0. Conclusions: EMP levels were similar in patients with AIS and stroke mimic patients. The PECAM-1/E-selectin ratio demonstrated that EMPs were generated via activation and not apoptosis/necrosis. This suggests that EMPs may not be a good marker for AIS, given the inability to discriminate between stroke mimics and AIS. ACADEMIC EMERGENCY MEDICINE 2007; 14:685-690 (c) 2007 by the Society for Academic Emergency Medicine. C1 MCHE, EMR, SAUSHEC,Emergency Med Residency, Dept Emergency Med,Brooke Army Med Ctr, Ft Sam Houston, TX USA. Univ Cincinnati, Dept Obstet, Cincinnati, OH USA. Univ Cincinnati, Dept Gynecol, Cincinnati, OH USA. RP Williams, JB (reprint author), MCHE, EMR, SAUSHEC,Emergency Med Residency, Dept Emergency Med,Brooke Army Med Ctr, Ft Sam Houston, TX USA. EM justin.williams2@amedd.army.mil OI Lindsell, Christopher/0000-0002-3297-2811 FU NICHD NIH HHS [HD 40363] NR 21 TC 30 Z9 30 U1 0 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD AUG PY 2007 VL 14 IS 8 BP 685 EP 690 DI 10.1197/j.aem.2007.04.009 PG 6 WC Emergency Medicine SC Emergency Medicine GA 194DV UT WOS:000248325300001 PM 17606807 ER PT J AU Forys, K McKellar, J Moos, R AF Forys, Kelly McKellar, John Moos, Rudolf TI Participation in specific treatment components predicts alcohol-specific and general coping skills SO ADDICTIVE BEHAVIORS LA English DT Article DE approach coping; avoidance coping; self-help groups; substance use disorder; treatment outcomes ID SUBSTANCE-ABUSE; USE DISORDERS; BEHAVIORAL TREATMENT; TREATMENT OUTCOMES; SELF-EFFICACY; 1-YEAR; MECHANISMS; SMOKING; MEN AB This study identified which aspects of substance abuse treatment in community residential facilities (CRFs) were correlated with patients' post-treatment coping. A total of 2376 patients supplied demographic information and completed measures at baseline (coping and abstinence self-efficacy) and one year after treatment (coping, level of drug and alcohol use, and substance-related problems). Staff provided information about treatment orientation and patients' participation in treatment (e.g., life skills training, vocational counseling). The data were used to predict coping 1 year after treatment. As expected, higher levels of general approach coping and alcohol-specific coping and lower levels of general avoidance coping were associated with less 1-year alcohol and drug use and fewer drinking problems. Patients' greater level of participation in life skills counseling predicted more approach coping at 1 year. In addition, positive social relationships and participation in 12-step self-help groups predicted less general avoidance coping and more alcohol-specific coping at 1 year post-treatment. Life skills training, 12-step self-help groups, and enhancement of supportive relationships during CRF treatment for substance abuse are related to healthy coping. Future research should examine the effect of these components in less intensive programs and with women. (c) 2006 Elsevier Ltd. All rights reserved. C1 VA Palo Alto Hlth Care Syst, Menlo Pk, CA 94025 USA. Stanford Univ, Sch Med, Stanford, CA 94305 USA. RP Forys, K (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Hlth Promot & Wellness, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM kelly.forys@us.army.mil; john.mckellar@va.gov; rmoos@stanford.edu NR 29 TC 19 Z9 20 U1 4 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4603 J9 ADDICT BEHAV JI Addict. Behav. PD AUG PY 2007 VL 32 IS 8 BP 1669 EP 1680 DI 10.1016/j.addbeh.2006.11.023 PG 12 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA 179PS UT WOS:000247302800011 PM 17182195 ER PT J AU Rupp, TL Acebo, C Van Reen, E Carskadon, MA AF Rupp, Tracy L. Acebo, Christine Van Reen, Eliza Carskadon, Mary A. TI Effects of a moderate evening alcohol dose. I: Sleepiness SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE extended waking; alcohol; sleepiness; MSLT; circadian timing ID PERFORMANCE; ETHANOL; ALERTNESS; RESTRICTION; DEPRIVATION; EXTENSION; ALPHA AB Background: Few studies examining alcohol's effects consider prior sleep/wake history and circadian timing. We examined introspective and physiological sleepiness on nights with and without moderate alcohol consumption in well-rested young adults at a known circadian phase. Methods: Twenty-nine adults (males=9), ages 21 to 25 years (M=22.6, SD=1.2), spent 1 week on an at-home stabilized sleep schedule (8.5 or 9 hours), followed by 3 in-lab nights: adaptation, placebo, and alcohol. Alcohol (vodka; 0.54 g/kg for men; 0.49 g/kg for women) or placebo beverage was consumed over 30 minutes ending 1 hour before stabilized bedtime. In addition to baseline, 3 sleep latency tests (SLTs) occurred after alcohol/placebo ingestion (15, 16.5, and 18 hours after waking). Stanford Sleepiness Scales (SSS) and Visual Analog Scales (VAS) of sleepiness were completed before each SLT and approximately every 30 minutes. The Biphasic Alcohol Effects Scale (BAES) was administered a total of 4 times (baseline, 5, 60, and 90 minutes postalcohol/placebo). Subjects' circadian phase was determined from melatonin levels in saliva samples taken at approximately 30-minute intervals. Results: All sleepiness and sedation measures increased with time awake. Only SSS and BAES sedation measures showed higher levels of sleepiness and sedation after alcohol compared with placebo. The mean circadian phase was the same for assessments at both conditions. Conclusions: Alcohol did not increase physiological sleepiness compared with placebo nor was residual sedation evident under these conditions. We conclude that the effects on sleepiness of a moderate dose of alcohol are masked when sleep-wake homeostatic and circadian timing influences promote high levels of sleepiness. C1 EP Bradley Sleep & Chronobiol Lab, Providence, RI USA. Brown Univ, Dept Psychol, Providence, RI 02912 USA. Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA. RP Rupp, TL (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, 503 Robert Grant Ave,Room 2W88, Silver Spring, MD 20910 USA. EM tracy.rupp@amedd.army.mil FU NIAAA NIH HHS [AA13252] NR 26 TC 9 Z9 9 U1 1 U2 5 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0145-6008 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD AUG PY 2007 VL 31 IS 8 BP 1358 EP 1364 DI 10.1111/j.1530-0277.2007.00433.x PG 7 WC Substance Abuse SC Substance Abuse GA 190FS UT WOS:000248044300010 PM 17550363 ER PT J AU Rupp, TL Acebo, C Seifer, R Carskadon, MA AF Rupp, Tracy L. Acebo, Christine Seifer, Ronald Carskadon, Mary A. TI Effects of a moderate evening alcohol dose. II: Performance SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE extended waking; alcohol; driving simulation; reaction time; circadian timing ID CHRONIC SLEEP RESTRICTION; PROLONGED WAKEFULNESS; DEPRIVATION; TASK; IMPAIRMENT AB Background: This second of a pair of papers investigates the effects of a moderate dose of alcohol and staying up late on driving simulation performance and simple visual reaction time (RT) at a known circadian phase in well-rested young adults. Methods: Twenty-nine adults (9 males), ages 21 to 25 years, spent 1 week on an at-home stabilization schedule of 8.5 to 9 hours, followed by 3 nonconsecutive nights in-lab: adaptation, placebo, and alcohol. Performance task practice occurred on 3 occasions before the study. Alcohol (vodka; 0.54 g/kg men; 0.49 g/kg women mixed with tonic) was consumed over 30 minutes ending 1 hour before normal bedtime; the same quantity of beverage was given on placebo. Driving simulation (with drive-only and dual-task drive and subtract components) and psychomotor vigilance task (PVT) testing occurred before and after alcohol/placebo ingestion. Breath alcohol concentration (BrAC) readings were taken before all test sessions. Saliva samples were taken approximately every 30 minutes to determine circadian phase. Results: Driving simulation and PVT variables significantly deteriorated with increasing time awake. Driving simulator lane variability was worse with alcohol compared with placebo at 15.5 hours awake. No PVT variable showed an effect of alcohol. Conclusions: Driving simulation performance deteriorated with extended waking and with alcohol; driving was most impaired at the peak alcohol level. The PVT, less complex than the driving simulation, did not show effects of alcohol, a finding consistent with previous literature that disruptive effects of low alcohol concentrations increase with task complexity. Overall, simulated driving performance is significantly impaired late at night when even a moderate dose of alcohol is consumed. C1 EP Bradley Sleep & Chronobiol Lab, Providence, RI USA. Brown Univ, Dept Psychol, Providence, RI 02912 USA. Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA. Brown Univ, Ctr Study Human Dev, Providence, RI 02912 USA. RP Rupp, TL (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, 503 Robert Grant Ave,Room 2W88, Silver Spring, MD 20910 USA. EM tracy.rupp@amedd.army.mil OI Seifer, Ronald/0000-0003-4879-2839 FU NIAAA NIH HHS [AA13252] NR 19 TC 9 Z9 11 U1 0 U2 9 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0145-6008 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD AUG PY 2007 VL 31 IS 8 BP 1365 EP 1371 DI 10.1111/j.1530-0277.2007.00434.x PG 7 WC Substance Abuse SC Substance Abuse GA 190FS UT WOS:000248044300011 PM 17550362 ER PT J AU Bellasi, A Lacey, C Taylor, AJ Raggi, P Wilson, PWF Budoff, MJ Vaccarino, V Shaw, LJ AF Bellasi, Antonio Lacey, Carolyn Taylor, Allen J. Raggi, Paolo Wilson, Peter W. F. Budoff, Matthew J. Vaccarino, Viola Shaw, Leslee J. TI Comparison of prognostic usefulness of coronary artery calcium in men versus women (Results from a meta- and pooled analysis estimating all-cause mortality and coronary heart disease death or myocardial infarction) SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID ELECTRON-BEAM TOMOGRAPHY; RISK-FACTORS; CALCIFICATION; EVENTS; SCORE; PREDICTION; CARDIOLOGY; COMMITTEE; ADULTS; SEX AB Women with coronary heart disease (CHD) have higher mortality compared with men. Atherosclerotic imaging risk markers are associated with higher mortality and relative risk of CHD events, in women compared with men. However, data on the predictive accuracy of coronary artery calcium (CAC) in women are scarce. We performed a systematic review of the Published literature from 2003 to 2006 on the prognostic value of CAC in women and men. Two investigators reviewed Medline for prospective registries on annual rates of CHD death or myocardial infarction (MI) by CAC results. Three studies in 6,481 women and 13,697 men reported results by gender. We also analyzed 2 observational registries for annual all-cause death rates by CAC scores in women (n = 17,779) and men (n = 17,850). Summary relative risk ratios and 95% confidence intervals were calculated using a random effects model. For all-cause mortality, rates were 0.1% to 1.6% per year for women and 0.1% to 2.6% for men witli CAC scores from 0 to 10 to >= 1,000, respectively (p < 0.0001). For CHD death or MI, annual rates were 0.2% to 1.3% in women and 0.3% to 2.4% for men with low- to high-risk CAC scores. For women with a CAC score of 0, annual CHD death or MI rates were 0.16%, similar to that of men (p = 0.55). Summary relative risk ratios increased 4.9-fold(p = 0.006), 5.5-fold (p = 0.002), and 8.7-fold (p < 0.0001) for mild-, moderate-, and high-risk CAC scores, respectively. A comparative analysis of gender differences showed no significant differences between women and men for mild- to high-risk CAC scores (p = 0.66), suggesting an equivalent ability to risk stratify by gender. In conclusion, this meta- and pooled analysis revealed that CAC screening is equally accurate in stratifying risk in women and men. (c) 2007 Elsevier Inc. All rights reserved. C1 Emory Univ, Sch Med, Atlanta, GA 30322 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Calif Los Angeles, Biomed Res Inst, Torrance, CA USA. RP Shaw, LJ (reprint author), Emory Univ, Sch Med, Atlanta, GA 30322 USA. EM lshaw3@emory.edu RI Bellasi, Antonio/M-3744-2013 OI Bellasi, Antonio/0000-0001-7830-1645 NR 18 TC 51 Z9 55 U1 0 U2 4 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD AUG 1 PY 2007 VL 100 IS 3 BP 409 EP 414 DI 10.1016/j.amjcard.2007.03.037 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 197TJ UT WOS:000248579100005 PM 17659919 ER PT J AU Hodgson, CL Shriver, CD Gutchell, E Gutchell, V Bronfman, L AF Hodgson, Carol L. Shriver, Craig D. Gutchell, Emily Gutchell, Veronica Bronfman, Lee TI Interdisciplinary planning is provided for newly diagnosed breast cancer patients in a one-day visit at the walter reed comprehensive breast center SO AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-3732 J9 AM J CLIN ONCOL-CANC JI Am. J. Clin. Oncol.-Cancer Clin. Trials PD AUG PY 2007 VL 30 IS 4 MA 5 BP 446 EP 446 PG 1 WC Oncology SC Oncology GA 199KW UT WOS:000248695700027 ER PT J AU Sonek, J Borenstein, M Downing, C McKenna, D Neiger, R Croom, C Genrich, T Nicolaides, KH AF Sonek, Jiri Borenstein, Marisa Downing, Cathy McKenna, David Neiger, Ran Croom, Christopher Genrich, Toby Nicolaides, Kypros H. TI Frontomaxillary facial angles in screening for trisomy 21 at 14-23 weeks' gestation SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE frontomaxillary facial angle; maxilla; second trimester screening; trisomy 21; 2-dimensional ultrasound ID NASAL BONE; DOWN-SYNDROME; 2ND-TRIMESTER FETUSES; NUCHAL-TRANSLUCENCY; ABNORMALITIES; ULTRASOUND; THICKNESS; LENGTH AB OBJECTIVE: The objective of the study was to investigate the potential value of the frontomaxillary facial ( FMF) angle in second- trimester ultrasound screening for trisomy 21. METHODS: We examined stored images of fetal profiles taken before amniocentesis at 14- 24 weeks from 100 euploid fetuses and 34 with trisomy 21. The FMF angles between the upper surface of the upper palate and the frontal bone ( FMFbone) and the skin over the forehead ( FMFskin) were measured. RESULTS: In the euploid group the FMF angles decreased with gestation. In the fetuses with trisomy 21, the FMFbone and FMFskin angles were 79.4% and 87.9% above the 95th percentile for gestation of the respective values from the euploid group. In trisomy 21 fetuses, there was no significant difference in FMF angles between those with nasal bone hypoplasia ( n = 19) and those without ( n = 15). CONCLUSION: The FMF angle is substantially higher in trisomy 21 than euploid fetuses. Measurement of the FMF angles is likely to prove a useful method in prenatal screening for trisomy 21 in the second trimester. C1 Kings Coll Hosp London, Sch Med, Harris Birthright Res Ctr Fetal Med, London SE5 8RX, England. Wright State Univ, Dept Obstet & Gynecol, Dayton, OH 45435 USA. USA, Fetal Med Fdn, Dayton, OH USA. RP Nicolaides, KH (reprint author), Kings Coll Hosp London, Sch Med, Harris Birthright Res Ctr Fetal Med, Denmark Hill, London SE5 8RX, England. NR 19 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD AUG PY 2007 VL 197 IS 2 DI 10.1016/j.ajog.2007.03.059 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 199TU UT WOS:000248718900014 ER PT J AU Cabrera, OA Hoge, CW Bliese, PD Castro, CA Messer, SC AF Cabrera, Oscar A. Hoge, Charles W. Bliese, Paul D. Castro, Carl A. Messer, Stephen C. TI Childhood adversity and combat as predictors of depression and post-traumatic stress in deployed troops SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID GULF-WAR VETERANS; HOUSEHOLD DYSFUNCTION; RETROSPECTIVE REPORTS; HEALTH-PROBLEMS; MENTAL-HEALTH; PRIMARY-CARE; EXPERIENCES; ADULT; ABUSE; DISORDER AB Background: Previous studies have shown a relationship between childhood adversity and health outcomes in adulthood. The military represents a segment of the young working population that faces unique hazards that may be worsened by previous adverse life experiences. To date, no comprehensive studies of childhood adversity have been conducted with military samples that have included combat troops before and after a combat deployment. Methods: Surveys were administered in 2003 to 4529 male soldiers who had not deployed to Iraq, and in 2004 to a separate group of 2392 male soldiers 3 months after returning from Iraq. The main predictor was adverse childhood experiences, an aggregated construct representing incremental exposure to six types of traumatic childhood experiences. This construct correlated with depression and post-traumatic stress disorder rates, as well as symptom scores. For the post-Iraq sample, analyses were conducted to assess whether individuals with childhood trauma were affected differently by exposure to combat. Results: The likelihood of screening positive for depression and post-traumatic stress disorder was significantly higher for individuals reporting exposure to two or more categories of childhood adversity. Core analyses showed that adverse childhood experiences were a significant predictor of mental health symptoms, beyond the expected contribution of combat. Conclusions: This study confirms the high prevalence of adverse childhood experiences and the association of these experiences with key mental health outcomes. In addition, the results highlight the importance of considering pre-enlistment childhood traumatic experiences as well as the level of combat exposure in the treatment of military personnel returning from combat operations. C1 US Army Med Res Unit Europe, Heidelberg, Germany. Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD USA. RP Cabrera, OA (reprint author), US Army Med Res Unit Europe, Karlsruher Str 144, Heidelberg, Germany. EM oscar.cabrera@us.army.mil RI Messer, Stephen/B-6198-2012 OI Messer, Stephen/0000-0003-0503-9695 NR 33 TC 93 Z9 94 U1 3 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD AUG PY 2007 VL 33 IS 2 BP 77 EP 82 DI 10.1016/j.amepre.2007.03.019 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 197UP UT WOS:000248582300001 PM 17673093 ER PT J AU White, DW Wenke, JC Mosely, DS Mountcastle, SB Basamania, CJ AF White, Daniel W. Wenke, Joseph C. Mosely, Dan S. Mountcastle, Sally B. Basamania, Carl J. TI Incidence of major tendon ruptures and anterior cruciate ligament tears in US army soldiers SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE pectoralis major tendon rupture; quadriceps tendon rupture; patellar tendon rupture; Achilles tendon rupture; race; mechanism of injury ID ACHILLES-TENDON; BILATERAL RUPTURE; INJURY; BLACK; BASKETBALL; AMERICAN; RACE; MEN AB Background: Although a rare event, the prevalence of major tendon rupture has increased in recent decades. Identification of risk factors is important for prevention purposes. Hypothesis: Race is a risk factor for major tendon ruptures. Study Design: Cohort study (prevalence); Level of evidence, 2. Methods: All patients admitted for surgical management of a rupture of a major tendon at Womack Army Medical Center, Fort Bragg, North Carolina, in 1995 and 1996 were identified and evaluated for risk factors. Results: The authors identified 52 major tendon ruptures: 29 Achilles, 12 patellar, 7 pectoralis major, and 4 quadriceps tendon ruptures. All patients were active-duty soldiers, and 1 was a female soldier. Forty-one tendon ruptures occurred among black soldiers, 8 occurred among white soldiers, and 3 occurred among Latino soldiers. The population at risk included 93 224 exposures during the 2-year period, of which 67.1 % were white, 24.5% were black, and 8.4% were self-classified as other race. The rate ratio for tendon rupture, adjusted for gender and age, was 13.3 (95% confidence interval, 6.2-28.5) between blacks and whites and 2.9 (95% confidence interval, 0.8-10.9) between Latinos and whites. Conclusion: The rate of major tendon rupture was 13 times greater for black men in this study population when compared with whites. Interventions among those at a higher risk for injury should be considered. C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. DeWitt Army Hosp, Ft Belvoir, VA USA. Keller Army Hosp, West Point, NY USA. Duke Univ, Med Ctr, Durham, NC USA. RP White, DW (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM daniel.w.white@us.army.mil NR 32 TC 23 Z9 24 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD AUG PY 2007 VL 35 IS 8 BP 1308 EP 1314 DI 10.1177/0363546507301256 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 196AB UT WOS:000248452500011 PM 17468380 ER PT J AU Parker, TM Murray, CK Richards, AL Samir, A Ismail, T Fadeel, MA Jiang, J Wasfy, MO Pimentel, G AF Parker, Tina M. Murray, Clinton K. Richards, Allen L. Samir, Ahmed Ismail, Tharwat Fadeel, Moustafa Abdel Jiang, Ju Wasfy, Momtaz O. Pimentel, Guillermo TI Concurrent infections in acute febrile illness patients in Egypt SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SURVEILLANCE; LEPTOSPIROSIS; BRUCELLOSIS; AGENTS; FEVER AB We report the occurrence of concurrent infections with multiple acute febrile illness (AFI) pathogens during an ongoing prospective laboratory-based surveillance in four infectious disease hospitals in urban and rural areas of Egypt from June 2005 to August 2006. Patients were screened for Leptospira, Rickettsia typhi, Brucella, or Salmonella enterica serogroup Typhi by various methods including serology, culture, and PCR. One hundred eighty-seven of 1,510 patients (12.4%) evaluated had supporting evidence for the presence of coinfections; 20 (1%) of these patients had 2 or more pathogens based upon confirmatory 4-fold rise in antibody titer, culture, and/or PCR. Most coinfected patients lived or worked in rural agricultural areas. The high coinfection rates suggest that defining the etiologies of AFI is imperative in guiding proper disease treatment, prevention, and control strategies in Egypt. C1 USN, Med Unit 3, Cairo 09835, Egypt. Brooke Army Med Ctr, Houston, TX USA. Naval Med Ctr, Rickettsial Dis Dept, Silver Spring, MD USA. RP Parker, TM (reprint author), USN, Med Unit 3, Cairo 09835, Egypt. EM tina-parker@uiowa.edu; Clinton.Murray@amedd.army.mil; richardsa@nmrc.navy.mil; ahmed.samir@namru3.med.navy.mil; ismailt@namru3.med.navy.mil; fadeelm@namru3.med.navy.mil; jiangj@nmrc.navy.mil; wasfym@namru3.med.navy.mil; pimentelg@namru3.med.navy.mil RI Valle, Ruben/A-7512-2013; OI Pimentel, Guillermo/0000-0003-2464-1526 NR 17 TC 24 Z9 24 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2007 VL 77 IS 2 BP 390 EP 392 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 198OW UT WOS:000248638400034 PM 17690420 ER PT J AU Cohen, SP Shockey, SM Carragee, EJ AF Cohen, Steven P. Shockey, Sean M. Carragee, Eugene J. TI The efficacy of repeat intradiscal electrothermal therapy SO ANESTHESIA AND ANALGESIA LA English DT Article ID LOW-BACK-PAIN; LUMBAR SPINE; DISC; TEMPERATURE AB Nine consecutive patients with discogenic low back pain who obtained excellent pain relief from intradiscal electrothermal therapy were treated with a repeat procedure after the beneficial effects had diminished. Although 4 of 9 patients obtained >= 50% pain relief and were satisfied with the results, both the degree and duration of benefit were less pronounced than after the first procedure. Prospective studies are needed to identify the best candidates for repeat intradiscal electrothermal therapy. C1 Johns Hopkins Univ, Sch Med, Pain Management Div, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA. Walter Reed Army Med Ctr, Dept Surg, Anesthesia Serv, Washington, DC 20307 USA. Stanford Univ, Sch Med, Dept Orthoped Surg, Stanford, CA 94305 USA. RP Cohen, SP (reprint author), Johns Hopkins Univ, Sch Med, Pain Management Div, Dept Anesthesiol & Crit Care Med, 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu NR 19 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD AUG PY 2007 VL 105 IS 2 BP 495 EP 498 DI 10.1213/01.ane.0000268499.62456.67 PG 4 WC Anesthesiology SC Anesthesiology GA 194KN UT WOS:000248343400035 PM 17646511 ER PT J AU Li, QG Kozar, MP Shearer, TW Xie, LH Lin, AJ Smith, KS Si, YZ Anova, L Zhang, J Milhous, WK Skillman, DR AF Li, Qigui Kozar, Michael P. Shearer, Todd W. Xie, Lisa H. Lin, Ai J. Smith, Kirsten S. Si, Yuanzheng Anova, Lalaine Zhang, Jing Milhous, Wilbur K. Skillman, Donald R. TI Pharmacokinetics, safety, and hydrolysis of oral pyrroloquinazolinediamines administered in single and multiple doses in rats SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM-FALCIPARUM; ANTIMALARIAL DRUGS; BODY-WEIGHT; EXPOSURE; ANOREXIA; MALARIA; ANTIMETABOLITES; DERIVATIVES; VARIABLES; TOXICITY AB Pyrroloquinazolinediamine (PQD) derivatives such as tetra-acetamide PQD (PQD-A4) and bis-ethylcarbamyl PQD (PQD-BE) were much safer (with therapeutic indices of 80 and 32, respectively) than their parent compound, PQD (therapeutic index, 10). Further evaluation of PQD-A4 and PQD-BE in single and multiple pharmacokinetic (PK) studies as well as corresponding toxicity studies was conducted with rats. PQD-A4 could be converted to two intermediate metabolites (monoacetamide PQD and bisacetamide PQD) first and then to the final metabolite, PQD, while PQD-BE was directly hydrolyzed to PQD without precursor and intermediate metabolites. Maximum tolerant doses showed that PQD-A4 and PQD-BE have only 1/12 and 1/6, respectively, of the toxicity of PQD after a single oral dose. Compared to the area under the concentration-time curve for PQD alone (2,965 ng center dot h/ml), values measured in animals treated with PQD-A4 and PQD-BE were one-third (1,047 ng - h/ml) and one-half (1,381 ng - h/ml) as high, respectively, after an equimolar dosage, suggesting that PQD was the only agent to induce the toxicity. Similar results were also shown in multiple treatments; PQD-A4 and PQD-BE generated two-fifths and three-fifths, respectively, of PQD concentrations, with 8.8-fold and 3.8-fold safety margins, respectively, over the parent drug. PK data indicated that the bioavailability of oral PQD-A4 was greatly limited at high dose levels, that PQD-A4 was slowly converted to PQD via a sequential three-step process of conversion, and that PQD-A4 was significantly less toxic than the one-step hydrolysis drug, PQD-BE. It was concluded that the slow and smaller release of PQD was the main reason for the reduction in toxicity and that the active intermediate metabolites can still maintain antimalarial potency. Therefore, the candidate with multiple-step hydrolysis of PQD could be developed as a safer potential agent for malaria treatment. C1 Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Expt Therapeut, Dept Pharmacol, Washington, DC 20307 USA. RP Li, QG (reprint author), Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Expt Therapeut, Dept Pharmacol, 503 Robert Grant Ave, Washington, DC 20307 USA. EM qigui.li@na.amedd.army.mil RI Kozar, Michael/A-9155-2011 NR 27 TC 4 Z9 4 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2007 VL 51 IS 8 BP 2898 EP 2904 DI 10.1128/AAC.00932-06 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 196ZZ UT WOS:000248523700032 PM 17562804 ER PT J AU Lyons, WB Harmon, RS Long, DT AF Lyons, W. Berry Harmon, Russell S. Long, David T. TI Watershed-scale geochemistry SO APPLIED GEOCHEMISTRY LA English DT Editorial Material C1 Ohio State Univ, Byrd Polar Res Ctr, Columbus, OH 43210 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. RP Lyons, WB (reprint author), Ohio State Univ, Byrd Polar Res Ctr, 1090 Carmack Rd, Columbus, OH 43210 USA. EM russell.harmon@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0883-2927 J9 APPL GEOCHEM JI Appl. Geochem. PD AUG PY 2007 VL 22 IS 8 BP 1680 EP 1681 DI 10.1016/i.apgeochem.2007.03.028 PG 2 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 214AY UT WOS:000249709600012 ER PT J AU Danylov, AA Waldman, J Goyette, TM Gatesman, AJ Giles, RH Linden, KJ Neal, WR Nixon, WE Wanke, MC Reno, JL AF Danylov, Andriy A. Waldman, Jerry Goyette, Thomas M. Gatesman, Andrew J. Giles, Robert H. Linden, Kurt J. Neal, William R. Nixon, William E. Wanke, Michael C. Reno, John L. TI Transformation of the multimode terahertz quantum cascade laser beam into a Gaussian, using a hollow dielectric waveguide SO APPLIED OPTICS LA English DT Article ID WAVEGUIDE LASER; HETERODYNE RECEIVER; MODES AB We demonstrate that a short hollow dielectric tube can act as a dielectric waveguide and transform the multimode, highly diverging terahertz quantum cascade laser beam into the lowest order dielectric waveguide hybrid mode, EH11, which then couples efficiently to the free-space Gaussian mode, TEMoo. This simple approach should enable terahertz quantum cascade lasers to be employed in applications where a spatially coherent beam is required. (c) 2007 Optical Society of America. C1 Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. Spire Corp, Bedford, MA 01730 USA. USA, Natl Ground Intelligence Ctr, Charlottesville, VA 22911 USA. Sandia Natl Labs, Albuquerque, NM 87185 USA. RP Danylov, AA (reprint author), Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. EM andriy_danylov@student.uml.edu NR 25 TC 26 Z9 27 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD AUG 1 PY 2007 VL 46 IS 22 BP 5051 EP 5055 DI 10.1364/AO.46.005051 PG 5 WC Optics SC Optics GA 206EQ UT WOS:000249167100028 PM 17676114 ER PT J AU Young, AJ Castellani, JW AF Young, Andrew J. Castellani, John W. TI Exertional fatigue and cold exposure: mechanisms of hiker's hypothermia SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME LA English DT Article; Proceedings Paper CT Annual Meeting of teh Canadian-Society-of-Exercise-Physiologists CY NOV 10, 2005 CL Gatineau, CANADA SP Canadian Soc Exercise Physiologists DE thermoregulation; shivering; thermal balance; vasoconstriction ID MUSCLE GLYCOGEN; METABOLIC-RESPONSES; ACCIDENT PREVENTION; MEDICAL COMMISSION; PLASMA-GLUCOSE; HILL WALK; THERMOREGULATION; EXERCISE; HUMANS AB Participants in prolonged, physically demanding activities in cold weather are at risk of a condition known as "hiker's hypothermia". During exposure to cold weather, the increased gradient favoring body heat loss to the environment must be balanced by physiological responses, clothing, and behavioral strategies that conserve body heat stores, or else body temperature will decline. The primary human physiological responses elicited by cold exposure are shivering and peripheral vasoconstriction. Shivering increases thermogenesis and replaces body heat losses, while peripheral vasoconstriction improves thermal insulation of the body and retards the rate of heat loss. A body of scientific literature supports the concept that prolonged and (or) repeated cold exposure, fatigue induced by sustained physical exertion, or both together can impair shivering and vasoconstrictor response to cold. The mechanisms accounting for this thermoregulatory impairment are not clear, but the possibility that changes in blood glucose availability or sympathetic responsiveness to cold due to exertion and fatigue merit further research. C1 US Army Res Inst Environm Med, Natick, MA 01760 USA. RP Young, AJ (reprint author), US Army Res Inst Environm Med, Kansas St, Natick, MA 01760 USA. EM andrew.young@na.amedd.army.mil NR 22 TC 5 Z9 5 U1 2 U2 9 PU NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS PI OTTAWA PA BUILDING M 55, OTTAWA, ON K1A 0R6, CANADA SN 1715-5312 J9 APPL PHYSIOL NUTR ME JI Appl. Physiol. Nutr. Metab. PD AUG PY 2007 VL 32 IS 4 BP 793 EP 798 DI 10.1139/H07-041 PG 6 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA 204NW UT WOS:000249052300020 PM 17622297 ER PT J AU Shafer, DJ Sherman, TD Wyllie-Echeverria, S AF Shafer, Deborah J. Sherman, Timothy D. Wyllie-Echeverria, Sandy TI Do desiccation tolerances control the vertical distribution of intertidal seagrasses? SO AQUATIC BOTANY LA English DT Article DE desiccation; re-hydration; photosynthesis; Zostera japonica; Zostera marina ID ZOSTERA-MARINA L; SOUTHERN NEW-ZEALAND; FUCOID ALGAE; CHLOROPHYLL FLUORESCENCE; NET PHOTOSYNTHESIS; TEMPORAL PATTERNS; NOLTII HORNEM; USA ESTUARY; JAPONICA; ZONATION AB Photosynthetic processes in Zostera japonica, an upper intertidal species, were found to be more severely affected by desiccation than Z marina, a lower intertidal and subtidal species, at comparable levels of tissue water content. The data indicate that photosynthetic responses to desiccation at the level of the individual leaf are insufficient to explain observed patterns of intertidal seagrass zonation. Desiccation tolerance in seagrasses is more likely to involve a complex interaction of morphological traits and growth strategies at the level of the whole plant, such as downsizing (e.g. smaller, narrower leaves), reduced structural rigidity and increased rates of leaf abscission and leaf turnover. (C) 2007 Elsevier B.V. All rights reserved. C1 Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. Univ S Alabama, Dept Biol Sci, Mobile, AL 36688 USA. Univ Washington, Friday Harbor Labs, Friday Harbor, WA 98250 USA. RP Shafer, DJ (reprint author), Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Shaferd@wes.army.mil NR 44 TC 35 Z9 36 U1 4 U2 30 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3770 J9 AQUAT BOT JI Aquat. Bot. PD AUG PY 2007 VL 87 IS 2 BP 161 EP 166 DI 10.1016/j.aquabot.2007.04.003 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 197VL UT WOS:000248584500010 ER PT J AU Breedlove, J Cho, S Gunning, S Reed, W AF Breedlove, Jennifer Cho, Sunghun Gunning, Sean Reed, Walter TI Erythematous papules and plaques involving the groin and scrotum SO ARCHIVES OF DERMATOLOGY LA English DT Editorial Material ID CUTANEOUS METASTASIS; BLADDER-CANCER; CARCINOMA; SKIN C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Breedlove, J (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD AUG PY 2007 VL 143 IS 8 BP 1067 EP + DI 10.1001/archderm.143.8.1067-b PG 2 WC Dermatology SC Dermatology GA 199VS UT WOS:000248723900017 PM 17709671 ER PT J AU Cadarette, BS Santee, WR Robinson, SB Sawka, MN AF Cadarette, Bruce S. Santee, William R. Robinson, Scott B. Sawka, Michael N. TI Reflective inserts to reduce heat strain in body armor: Tests with and without irradiance SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE solar load; exercise; core temperature; skin temperature AB Background: This study evaluated adding reflective thermal inserts (RTI) to reduce the physiological strain during exercise-heat stress with a radiant load. RTI were used with a U.S. Army desert battle dress uniform, body armor, and helmet. Methods: Four male volunteers attempted four trials (10 min rest followed by 100 min walking at 1.56 m center dot s(-1).) All trials were at 40.0 degrees C dry bulb (TA), 12.4 degrees C dew point (Tdp), 20% RH, and 1.0 m center dot s(-1) wind speed. On 2 d, there was supplementary irradiance (+1) with globe temperature (Tbg) = 56.5 degrees C and on 2 d there was no supplementary irradiance (-1) with Tbg similar to Tdb. Trial conditions were: 1) RTI and armor with supplementary irradiance (RA+1); 2) plain armor with supplementary irradiance (PA+1); 3) RTI and armor with no supplementary irradiance (RA-1); and 4) plain armor with no supplementary irradiance (PA-1). Results: Endurance times were not significantly different among trials. With one exception, armor and helmet interior and exterior surface temperatures were not significantly different between either RA+1 and PA+1 or RA-1 and PA-1. Temperature on the inside of the helmet in RA+1 (47.1 +/- 1.4 degrees C) was significantly lower than in PA+1 (49.5 +/- 2.6 degrees C). There were no differences for any physiological measure (core temperature, heart rate, mean weighted skin temperature, forehead skin temperature, sweating rate, evaporative cooling, rate of heat storage) between either RA+1 and PA+1 or RA-1 and PA-1. Conclusions: Results showed no evidence that wearing RTI with body armor and heir-net reduces physiological strain during exercise-heat stress with either high or low irradiance. C1 USA, Inst Environm Med, Natick, MA 01760 USA. RP Cadarette, BS (reprint author), USA, Inst Environm Med, Natick, MA 01760 USA. EM bruce.cadarette@us.army.mil NR 9 TC 5 Z9 5 U1 0 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 2007 VL 78 IS 8 BP 809 EP 813 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 198NG UT WOS:000248634200010 PM 17760290 ER PT J AU Lenz, JM Grodowitz, MJ Kennedy, JH AF Lenz, Jennifer M. Grodowitz, Michael J. Kennedy, James H. TI A physiological age-grading system for female Hydrellia pakistanae Deonier (Diptera : Ephydridae) SO BIOLOGICAL CONTROL LA English DT Article DE Hydrellia pakistanae; Hydrilla verticillata; biological control; age-grading; follicular relics ID HYDRILLA-VERTICILLATA HYDROCHARITACEAE; BIOLOGICAL-CONTROL; ADULT INSECTS; GROWTH; HERBIVORY; IMPACT AB The female reproductive system of Hydrellia pakistanae Deonier was described by dissecting individuals of known ages and describing changes in relation to number of eggs oviposited. Female H. pakistanae have meroistic ovaries, in that specialized nurse cells or trophocytes (nutritive cells associated with the eggs') are present within each ovariole, and of the polytrophic subtype because nurse cells closely accompany each developing egg. or oocyte. The reproductive system includes two ovaries, each consisting of 8 or 10 tube-like ovarioles. The ovariole can be divided into two distinct areas: a distal germarium, which produces the follicles. and a more proximal vitellarium. which houses the developing follicles. Each ovariole is surrounded by an ovariole sheath and houses several developing follicles, a term referring to the ova (yolk and surrounding cells; i.e., the egg), nurse cells, and surrounding epithelium. Within an ovariole. the follicle proximate to the lateral oviduct is the most mature with each subsequent, more distal follicle becoming less mature. All ovarioles within an ovary are connected via the lateral oviducts, while the common oviduct connects the ovaries to each other. The spermatheca and accessory glands branch off the common oviduct. Sperm stored in the spermatheca fertilize eggs as they pass through the common oviduct. Based on this information the continuum of ovarian maturation was divided into three nulliparous and four parous stages. The milliparous stages are classified based on degree of ovariole segmentation and maturity of the most proximal follicle while follicle relic quantity and appearance is mainly used to separate the parous classes. Limited field sampling demonstrated the possibility of using this system to assess reproductive health of wild populations. (c) 2007 Elsevier Inc. All rights reserved. C1 Univ N Texas, Denton, TX 76203 USA. USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Grodowitz, MJ (reprint author), Univ N Texas, Denton, TX 76203 USA. EM jenlenz@hotmail.com; Michael.J.Grodowitz@erdc.usace.army.mil; kennedy@unt.edu NR 16 TC 1 Z9 1 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1049-9644 J9 BIOL CONTROL JI Biol. Control PD AUG PY 2007 VL 42 IS 2 BP 119 EP 128 DI 10.1016/j.biocontrol.2007.03.015 PG 10 WC Biotechnology & Applied Microbiology; Entomology SC Biotechnology & Applied Microbiology; Entomology GA 196WZ UT WOS:000248515000003 ER PT J AU Regules, JA Carlson, MD Wolf, SE Murray, CK AF Regules, Jason A. Carlson, Misty D. Wolf, Steven E. Murray, Clinton K. TI Analysis of anaerobic blood cultures in burned patients SO BURNS LA English DT Article DE burn patients; bacteremia; anaerobe; blood cultures ID CLINICAL-SIGNIFICANCE; WOUND INFECTIONS; STREAM INFECTIONS; BACTEREMIA; BACTERIOLOGY; POPULATION; FUNGEMIA; PERIOD; YIELD AB The utility of anaerobic blood culturing is often debated in the general population, but there is limited data on the modern incidence, microbiology, and utility of obtaining routine anaerobic blood cultures for burned patients. We performed a retrospective review of the burned patients electronic medical records database for all blood cultures drawn between January 1997 and September 2005. We assessed blood cultures for positivity, organisms identified, and growth in aerobic or anaerobic media. 85,103 blood culture sets were drawn, with 4059 sets from burned patients. Three hundred and forty-five single species events (619 total blood culture isolates) were noted in 240 burned patients. For burned patients, four isolates were obligate anaerobic bacteria (all Propionibacterium acnes). Anaerobic versus aerobic culture growth was recorded in 310 of 619 (50.1%) burned patient blood culture sets. 46 (13.5%) of the identified organisms, most of which were not obligate anaerobic bacteria, were identified from solely anaerobic media. The results of our study suggest that the detection of significant anaerobic bacteremia in burned patients is very rare and that anaerobic bottles are not needed in this population for that indication. However anaerobic blood cultures systems are also able to detect facultative and obligate aerobic bacteria; therefore, the deletion of the anaerobic culture medium may have deleterious clinical impact. Published by Elsevier Ltd and ISBI. C1 Brooke Army Med Ctr, MCHE MDI, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, MCHE MDI, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 36 TC 4 Z9 4 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD AUG PY 2007 VL 33 IS 5 BP 561 EP 564 DI 10.1016/j.burns.2006.10.390 PG 4 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 189KJ UT WOS:000247987500004 PM 17493763 ER PT J AU Stanley, JK Ramirez, AJ Chambliss, CK Brooks, BW AF Stanley, Jacob K. Ramirez, Alejandro J. Chambliss, C. Kevin Brooks, Bryan W. TI Enantiospecific sublethal effects of the antidepressant fluoxetine to a model aquatic vertebrate and invertebrate SO CHEMOSPHERE LA English DT Article DE chiral; enantiomer; toxicity; feeding behavior ID SEROTONIN REUPTAKE INHIBITORS; WASTE-WATER EFFLUENT; FOOD-INTAKE; PIMEPHALES-PROMELAS; CERIODAPHNIA-DUBIA; MASS-SPECTROMETRY; FEEDING-BEHAVIOR; NEUROPEPTIDE-Y; DAPHNIA-MAGNA; PHARMACEUTICALS AB Many contaminants are chiral compounds with enantiomers that may differ markedly in environmental fate, bioavailability, and toxicity. Enantiospecific environmental fate and ecotoxicological information are lacking for many chiral contaminants. The primary objective of this investigation included an assessment of potential enantiospecific differences in sublethal standardized and behavioral responses of the model organisms Pimephales promelas (teleost) and Daphnia magna (crustacean) to the widely prescribed chiral antidepressant fluoxetine. Endpoints assessed included D. magna immobilization, reproduction, and grazing rate and P. promelas survival, growth, and feeding rate. S-Fluoxetine was found to be more toxic to sublethal standardized and behavioral endpoints in P. promelas, potentially because its primary active metabolite, S-norfluoxetine, is more potent than the same metabolite of R-fluoxetine in mammals. This was not observed for D. magna responses. This differential enantiospecific response between model organisms may have resulted from closer target homology between mammals and fish than between mammals and crustaceans. P. promelas feeding rate, an ecologically relevant and mode-of-action related response, was the most sensitive endpoint tested for R- and S-fluoxetine with 10% effect concentration (EC10) values (+/- SE) of 16.1 ( +/- 20.2) and 3.7 ( +/- 4.6) mu g l(-1), respectively. Up to a 9.4-fold difference in toxicity between enantiomers was observed; P. promelas growth EC10s ( +/- SE) for R- and S-fluoxetine were 132.9 ( +/- 21.2) and 14.1 ( +/- 8.1) mu g l(-1), respectively. Such differences in sublethal responses to fluoxetine enantiomers suggest that enantiospecific toxicity and mode-of-action related responses that are ecologically relevant (e.g., feeding rate) should be considered in future ecological hazard and risk assessments for chiral contaminants. (c) 2007 Elsevier Ltd. All rights reserved. C1 Baylor Univ, Ctr Reservoir & Aquat Syst Res, Waco, TX 76798 USA. Baylor Univ, Dept Biol, Waco, TX 76798 USA. Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA. Baylor Univ, Dept Environm Studies, Waco, TX 76798 USA. RP Stanley, JK (reprint author), USA, Waterways Expt Stn, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jacob.k.stanley@us.army.mil RI Brooks, Bryan/B-2612-2010; Guenat, Heather/H-6528-2014; OI Brooks, Bryan/0000-0002-6277-9852; Chambliss, Kevin/0000-0003-3888-6890 NR 55 TC 105 Z9 108 U1 8 U2 74 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD AUG PY 2007 VL 69 IS 1 BP 9 EP 16 DI 10.1016/j.chemosphere.2007.04.080 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 207YV UT WOS:000249287900002 PM 17582462 ER PT J AU Gozalo, AS Lucas, CM Qin, J Hall, BT Magill, AJ AF Gozalo, Alfonso S. Lucas, Carmen M. Qin, Jing Hall, B. Ted Magill, Alan J. TI Anemia and antibodies to the 19-kDa fragment of MSP1 during Plasmodium falciparum infection in Aotus monkeys SO COMPARATIVE MEDICINE LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; HUMAN MALARIA; PARASITE; PROTECTION; CHALLENGE; ERYTHROCYTES; DESTRUCTION; NANCYMAI; ANTIGENS; EFFICACY AB To determine whether antibodies to the 19-kDa fragment of merozoite surface protein 1 (MSP1(19)) help to control blood-stage Plasmodium falciparum infection, we performed a rechallenge experiment of previously infected Aotus monkeys. Monkeys previously exposed to the FVO strain of P. falciparum that did or did not develop high antibody titers to MSP1(19) and malaria-naive monkeys were challenged with erythrocytes infected with the same strain. Prepatent periods were prolonged in previously infected monkeys compared with malaria-naive monkeys. Previously infected monkeys with preexisting anti-MSP1(19) antibodies showed low peak parasitemias that cleared spontaneously. Previously infected monkeys that had no or low levels of pre-existing anti-MSP1(19) antibodies also showed low peak parasitemias, but because of low hematocrits, all of these animals required treatment with mefloquine. All previously malaria-naive animals were treated because of high parasitemias. The results of this study suggest that antibody to the 19-kDa carboxy-terminal fragment of MSP1 plays a role in preventing the development of anemia, an important complication often associated with malaria. C1 USN, Med Res Ctr Detachment, Lima, Peru. NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. RP Gozalo, AS (reprint author), NIAID, Comparat Med Branch, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM gozaloa@niaid.nih.gov FU Intramural NIH HHS NR 28 TC 4 Z9 4 U1 0 U2 3 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD AUG PY 2007 VL 57 IS 4 BP 396 EP 401 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 199TH UT WOS:000248717600009 PM 17803055 ER PT J AU Gaffin, SL AF Gaffin, Stephen L. TI A pathophysiology-based approach to care of nuclear explosion victims SO CRITICAL CARE MEDICINE LA English DT Letter ID ANTIBODIES; ENDOTOXIN C1 Amer Univ Caribbean Med Sch, Dept Physiol, St Maarten, Neth Antilles. USA, Med Corps, Washington, DC 20310 USA. RP Gaffin, SL (reprint author), Amer Univ Caribbean Med Sch, Dept Physiol, St Maarten, Neth Antilles. NR 5 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD AUG PY 2007 VL 35 IS 8 BP 1998 EP 1998 DI 10.1097/01.CCM.0000277065.17594.4D PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 193CP UT WOS:000248251600036 PM 17667257 ER PT J AU Potter, MB Bowers, SB Pruitt, A AF Potter, Mark B. Bowers, Steven B. Pruitt, Alejandro TI Internal hernia with small bowel volvulus in a patient with altered gut motility: A complication of direct percutaneous endoscopic jejunostomy SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE direct percutaneous endoscopic jejunostomy; small bowel volvulus; small bowel obstruction; transthyretin amyloidosis; superior mesentery artery syndrome ID OBSTRUCTION; ADULTS C1 Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. Wilford Hall USAF Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Lackland AFB, TX USA. RP Potter, MB (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Mark.Potter@amedd.army.mil NR 22 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD AUG PY 2007 VL 52 IS 8 BP 1910 EP 1913 DI 10.1007/s10620-007-9813-5 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 185UN UT WOS:000247736000027 PM 17393307 ER PT J AU Hartzell, JD Peng, SW Wood-Morris, RN Sarmiento, DM Collen, JF Robben, PM Moran, KA AF Hartzell, Joshua D. Peng, Suzette W. Wood-Morris, Robert N. Sarmiento, Dennis M. Collen, Jacob F. Robben, Paul M. Moran, Kimberly A. TI Atypical Q fever in US soldiers SO EMERGING INFECTIOUS DISEASES LA English DT Article ID RESPIRATORY-DISTRESS SYNDROME; CHOLECYSTITIS AB Q fever is an emerging infectious disease among US soldiers serving in Iraq. Three patients have had atypical manifestations, including 2 patients with acute cholecystitis and 1 patient with acute respiratory distress syndrome. Providers must be aware of Q fever's signs and symptoms to avoid delays in treatment. C1 Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Combat Support Hosp 28, Baghdad, Iraq. RP Hartzell, JD (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, Ward 63,Bldg 2,6900 Georgia Ave NW, Washington, DC 20307 USA. EM hartzell@na.amedd.army.mil NR 13 TC 26 Z9 28 U1 0 U2 1 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD AUG PY 2007 VL 13 IS 8 BP 1247 EP 1249 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 197CK UT WOS:000248530900023 PM 17953104 ER PT J AU Waitumbi, JN Kifude, CM Withers, MR Polhemus, ME Heppner, DG Ogutu, BR AF Waitumbi, John N. Kifude, Carolyne M. Withers, Mark R. Polhemus, Mark E. Heppner, D. Gray, Jr. Ogutu, Bernhards R. TI Hb G-Philadelphia or Stanleyville II? When the phenotype and genotype do not agree SO EUROPEAN JOURNAL OF HAEMATOLOGY LA English DT Letter ID GENE; DELETIONS C1 Kenya Govt Med Res Ctr, Walter Reed Project, Nairobi 00621, Kenya. USA, Med Res Inst Infect Dis, Operat Med Dept, Div Med, Ft Detrick, MD 21702 USA. Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. RP Waitumbi, JN (reprint author), Kenya Govt Med Res Ctr, Walter Reed Project, UN Ave,Gigiri,Village Market, Nairobi 00621, Kenya. EM jwaitumbi@wrp-ksm.org NR 7 TC 5 Z9 5 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0902-4441 J9 EUR J HAEMATOL JI Eur. J. Haematol. PD AUG PY 2007 VL 79 IS 2 BP 177 EP 178 DI 10.1111/j.1600-0609.2007.00879.x PG 2 WC Hematology SC Hematology GA 195ZK UT WOS:000248450800015 PM 17608715 ER PT J AU Freed, MC AF Freed, Michael C. TI RealWorld evaluation: Working under budget, time, data, and political constraints SO EVALUATION AND PROGRAM PLANNING LA English DT Book Review C1 Walter Reed Army Med Ctr, Deployment Clin Ctr, Washington, DC 20307 USA. RP Freed, MC (reprint author), Walter Reed Army Med Ctr, Deployment Clin Ctr, Washington, DC 20307 USA. EM mc-freed@onebox.com NR 1 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0149-7189 J9 EVAL PROGRAM PLANN JI Eval. Program Plan. PD AUG PY 2007 VL 30 IS 3 BP 320 EP 321 DI 10.1016/j.evalprogplan.2007.05.002 PG 2 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA 202DN UT WOS:000248882300010 ER PT J AU Hsu, S Dickinson, D Borke, J Walsh, DS Wood, J Qin, HY Winger, J Pearl, H Schuster, G Bollag, WB AF Hsu, Stephen Dickinson, Douglas Borke, James Walsh, Douglas S. Wood, Joseph Qin, Haiyan Winger, Julia Pearl, Henna Schuster, George Bollag, Wendy B. TI Green tea polyphenol induces caspase 14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model SO EXPERIMENTAL DERMATOLOGY LA English DT Article DE caspase 14; EGCG; epidermal; green tea; keratinocyte polyphenols; psoriasiform lesions ID N-TERMINAL KINASE; TUMOR-CELLS; EXPRESSION; DIFFERENTIATION; INDUCTION; GENE; IDENTIFICATION; INHIBITION; ACTIVATION; PROTEINS AB Psoriasiform lesions are characterized by hyperproliferation and aberrant differentiation of epidermal keratinocytes, accompanied by inflammation, leading to a disrupted skin barrier with an abnormal stratum corneum. The expression and proteolytic processing of caspase 14, a member of the caspase family which is associated with epithelial cell differentiation, planned cell death, and barrier formation, is altered in psoriatic epidermis. We recently reported that human psoriatic tissues lack normal expression of caspase 14 [J Dermatol Sci 37 (2005) 61], and caspase 14 is induced by EGCG, a green tea polyphenol (GTP), in exponentially growing normal human epidermal keratinocytes (NHEK) [J Pharmacol Exp Ther 315 (2005) 805]. This suggests that GTPs may have beneficial effects on psoriasiform lesions. The current study aimed to determine whether MAPK pathways are required for GTP-induced caspase 14 expression in NHEK and if GTPs can modulate the expression of pathological markers in the psoriasiform lesions that develop in the flaky skin mouse. The results indicate that the p38 and JNK MAPK pathways are required for EGCG-induced expression of caspase 14 in NHEK. Importantly, topical application of 0.5% GTPs significantly reduced the symptoms of epidermal pathology in the flaky skin mice, associated with efficient caspase 14 processing and reduction in proliferating cell nuclear antigen levels. This suggests that GTP-activated pathways may be potential targets for novel therapeutic approaches to the treatment of some psoriasiform skin disorders. C1 Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, Augusta, GA 30912 USA. Walter Reed Army Inst Res, Dept Clin Trials, Silver Spring, MD USA. Eisenhower Army Med Ctr, Dept Clin Studies, Ft Gordon, GA USA. Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA. RP Hsu, S (reprint author), Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, AD1443, Augusta, GA 30912 USA. EM shsu@mail.mcg.edu FU NCI NIH HHS [CA097258]; NIAMS NIH HHS [AR45212] NR 39 TC 29 Z9 34 U1 1 U2 3 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0906-6705 J9 EXP DERMATOL JI Exp. Dermatol. PD AUG PY 2007 VL 16 IS 8 BP 678 EP 684 DI 10.1111/j.1600-0625.2007.00585.x PG 7 WC Dermatology SC Dermatology GA 186ZR UT WOS:000247817600008 PM 17620095 ER PT J AU Kess, HR Sundararaman, S Shah, CD Adams, DE Walsh, SM Pergantis, C Triplett, M AF Kess, H. R. Sundararaman, S. Shah, C. D. Adams, D. E. Walsh, S. M. Pergantis, C. Triplett, M. TI Identification of impact damage in S-2 glass composite missile casings using complementary vibration and wave propagation approaches SO EXPERIMENTAL MECHANICS LA English DT Article DE filament wound canisters; damage detection; wave propagation; vibration-based; beamformer ID STRUCTURAL DAMAGE; SENSORS; ARRAYS; TRANSMISSIBILITY AB The future United States military arsenal is transitioning from homogeneous metallic materials to stronger and lighter heterogeneous composite materials. Although these composites offer numerous advantages such as the ability to tune strength to weight ratios for each particular application, composites are susceptible to numerous damage mechanisms and environmental factors. Accidental in-field impacts resulting from mishandling or transportation loads have been identified by the U.S. Army as the primary cause of damage in composite weapon systems. This paper presents a hybrid approach to detect, locate, and quantify damage in filament wound canisters using a complementary set of vibration-based (transmissibility and embedded sensitivity) and wave propagation-based (phased array beamforming) methods. It is shown that this hybrid approach accurately detects, locates, and quantifies the damage imposed by 1.36 and 6.78 N-m impact energies. By measuring the static stiffness of the baseline canister at the mid-point, it was determined that the 1.36 N-m impact resulted in an overall 6% reduction of the tubes bending stiffness, while the 6.78 N-m impact resulted in a 28% reduction. C1 Purdue Univ, Ray W Herrick Labs, W Lafayette, IN 47907 USA. USA, Res Labs Weapons & Mat Res Directorate, Aberdeen, MD 21001 USA. Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Adams, DE (reprint author), Purdue Univ, Ray W Herrick Labs, 140 S Intramural Dr W, W Lafayette, IN 47907 USA. EM deadams@ecn.purdue.edu NR 24 TC 1 Z9 1 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD AUG PY 2007 VL 47 IS 4 BP 497 EP 509 DI 10.1007/s11340-007-9036-x PG 13 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA 189DQ UT WOS:000247970000005 ER PT J AU Bhattacharjee, AK AF Bhattacharjee, Apurba K. TI In silico three-dimensional pharmacophores for aiding the discovery of the Pfmrk (Plasmodium cyclin-dependent protein kinases) specific inhibitors for the therapeutic treatment of malaria SO EXPERT OPINION ON DRUG DISCOVERY LA English DT Review DE compound database; cyclin-dependent kinase; in silico pharmacophore; malaria; plasmodial CDK (Pfmrk); virtual screening AB The resurgence of malaria and lack of effective antimalarial drugs affect millions of people worldwide every year, causing several million deaths. With the emergence of structure-based drug design methodologies, a major thrust in drug discovery efforts has shifted towards targeting specific proteins in parasites that are involved in their metabolic pathways. Although cyclin-dependent kinases (CDKs), due to their direct role in cell cycle regulations, have been targeted for the development of cancer therapeutics, CDKs for Plasmodium falciparum have only been recently identified to be attractive for the discovery of antimalarials. One of the plasmodium CDK targets is Pfmrk. Being a putative homolog of Cdk7 and, thus, having the possibility of dual functions, both in cell cycle control and gene expression within the parasite, pfrmk has become an interesting antimalarial chemotherapeutic target. This review discusses how in silico methodologies, without the knowledge of the X-ray crystallographic structure of Pfmrk, particularly based on the development of pharmacophores on known inhibitors can aid the discovery and design of Pfmrk-specific inhibitors through virtual screening of compound databases and provides insights into the understanding of the mechanism of binding in the active site of this enzyme. C1 Walter Reed Army Inst Res, Dept Med Chem, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Dept Med Chem, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM apurba.bhattacharjee@na.amedd.army.mil NR 52 TC 3 Z9 3 U1 0 U2 4 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1746-0441 J9 EXPERT OPIN DRUG DIS JI Expert. Opin. Drug Discov. PD AUG PY 2007 VL 2 IS 8 BP 1115 EP 1127 DI 10.1517/17460441.2.8.1115 PG 13 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA V12RU UT WOS:000207617100008 PM 23484876 ER PT J AU Manzello, SL Gann, RG Kukuck, SR Prasad, K Jones, WW AF Manzello, Samuel L. Gann, Richard G. Kukuck, Scott R. Prasad, Kuldeep Jones, Walter W. TI Performance of a non-load-bearing steel stud gypsum board wall assembly: Experiments and modelling SO FIRE AND MATERIALS LA English DT Article DE compartmentation; fire resistance; partitions; wall; heat flux ID FIRE RESISTANCE AB A gypsum wall assembly was exposed to an intense real-scale compartment fire. For the wall assembly, temperatures were measured at the exposed face, within the stud cavity, and at the unexposed face during the fire exposure. Total heat flux gauges were used to measure the temporal variation of the energy incident on the walls, and cameras, both visual and infrared, were used to image the unexposed face of the wall assembly during the fire exposure. The behaviour of the wall assembly under the fire load is discussed as are current model results for a simulation of the fire test. Copyright (C) 2006 John Wiley & Sons, Ltd. C1 Natl Inst Stand & Technol, Bldg & Fire Res Lab, Gaithersburg, MD 20889 USA. US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Manzello, SL (reprint author), Natl Inst Stand & Technol, Bldg & Fire Res Lab, 100 Bureau Dr Stop 8662,Bldg 224,Room A361, Gaithersburg, MD 20889 USA. EM samuel.manzello@nist.gov NR 21 TC 12 Z9 12 U1 1 U2 11 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0308-0501 J9 FIRE MATER JI Fire Mater. PD AUG-SEP PY 2007 VL 31 IS 5 BP 297 EP 310 DI 10.1002/fam.939 PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 197QP UT WOS:000248571100002 ER PT J AU Brodsky, JW Pollo, FE Cheleuitte, D Baum, BS AF Brodsky, James W. Pollo, Fabian E. Cheleuitte, Domingo Baum, Brian S. TI Physical properties, durability, and energy-dissipation function of dual-density orthotic materials used in insoles for diabetic patients SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE materials; orthoses; physical properties ID REDUCE PLANTAR PRESSURES; THERAPEUTIC FOOTWEAR; SHEAR AB Background: Patients with neuropathic conditions may develop plantar bony deformities through neuropathic collapse, frequently placing the skin and soft tissues at risk. Orthoses have been used to accommodate and distribute plantar pressures over a large surface area, thereby minimizing peak loading pressures in small regions and reducing the risk of ulceration. Methods: A previously described bony prominence model (Brodsky et al.) was used to test the pressure-absorbing and force-transmission properties of various orthotic material combinations used in our outpatient clinic. Six materials were tested in five combinations of materials for their compressive properties: [MS]: medium plastazote (M) + soft plastazote (S); [MN]: medium plastazote (M) + nickelplast (N); [NP] nickelplast (N) + Poron (P); [MO] medium plastazote (M) + Spenco (O); and [MC] medium plastazote (M) + P-cell (C). Materials were tested for 100,000 cycles using a materials-testing system (MTS) apparatus (MTS Systems Corporation, Cary, NC) and software. Stress-strain curves comparing the measured peak pressure to the elastic deformation, or the percentage of compression a material experiences with respect to its original thickness, were plotted for each orthotic combination. Results: For MS, MN, MO, and to a lesser extent, MC, a trend was noted for decreased elastic deformation with increased testing. Additionally, the peak pressures before and after testing for each 10,000 testing cycle for each of the orthotic combinations were plotted. For both MN and NP, no demonstrable difference was noted in the peak pressures in the pretesting and post-testing for the 100,000 cycles. The MO showed a trend for increased peak pressures after each testing cycle. Both the MC and MS peak pressures markedly increased with respect to pretesting value. Also, the MN, MO, and MS all showed an overall trend for increased load cell values with increasing cycles at fast loading. Conclusions: These data showed that some orthotic combinations are more effective than others at reducing peak pressures during compression testing using our bony prominence model. Further studies are needed to test the orthotic combinations for shear and combined shear and compression modes. C1 Baylor Univ, Med Ctr, Dallas, TX 75246 USA. SW Orthoped Surg Specialists PLC, Tucson, AZ USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Brodsky, JW (reprint author), Baylor Univ, Med Ctr, 411 N Washington Ave,Suite 7000, Dallas, TX 75246 USA. RI Baum, Brian/K-2737-2012 OI Baum, Brian/0000-0003-0692-1962 NR 20 TC 8 Z9 8 U1 0 U2 10 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD AUG PY 2007 VL 28 IS 8 BP 880 EP 889 DI 10.3113/FAI.2007.0880 PG 10 WC Orthopedics SC Orthopedics GA 197EJ UT WOS:000248537100003 PM 17697652 ER PT J AU Shawen, SB Anderson, RB Cohen, BE Hammit, MD Davis, H AF Shawen, Scott B. Anderson, Robert B. Cohen, Bruce E. Hammit, Matthew D. Davis, Hodges TI Spherical ceramic interpositional arthroplasty for basal fourth and fifth metatarsal arthritis SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE arthroplasty; arthrosis; spherical; tarsometatarsal ID LISFRANC JOINT COMPLEX; TARSOMETATARSAL JOINTS; FRACTURE-DISLOCATION; ARTHRODESIS; INJURIES; MIDFOOT; TARSAL AB Background: Arthrosis of the fourth and fifth tarsometatarsal joints is difficult to treat. Arthrodesis is both difficult to achieve as well as disabling. Tendon interpositional arthroplasty has been performed with some success. A new technique using ceramic ball interpositional arthroplasty was evaluated. Methods: Between 2001 and 2003, 13 patients in whom nonoperative treatment had failed had resection arthroplasty of the base of the fourth or fifth metatarsals with ceramic ball interposition (Orthosphere, Wright Medical Technology, Arlington, Tennessee). Patients were evaluated using the American Orthopaedic Foot and Ankle Society (AOFAS) Midfoot Scale, a visual analogue scale, a satisfaction index, physical examination, and radiographs. Results: At an average 34-months followup, 11 of the 13 patients were available for evaluation. The five men and six women had an average age of 48 years. Seven patients reported a traumatic etiology. Average postoperative AOFAS score was 53 points, an 87% improvement over preoperative values. Visual analogue scale pain improved 42%. All 11 patients were satisfied and would undergo the operation again. One of the patients demonstrated subsidence of the implant into the cuboid but continued to have improvement in symptoms. To date there have been no implant dislocations. Three of the 11 patients had differential injections before surgery. Conclusions: Lateral column tarsometatarsal interpositional arthroplasty is an effective salvage operation for lateral column midfoot arthrosis and should be considered in this patient population. The use of the ceramic ball allows a technically simple procedure and rapid recovery. C1 Walter Reed Army Med Ctr, Orthopaed Surg Serv, Washington, DC 20307 USA. Texas Orthopaed & Sports Med, Houston, TX USA. RP Shawen, SB (reprint author), Walter Reed Army Med Ctr, Orthopaed Surg Serv, Washington, DC 20307 USA. EM scott.shawen@us.army.mil NR 20 TC 9 Z9 9 U1 0 U2 1 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD AUG PY 2007 VL 28 IS 8 BP 896 EP 901 DI 10.3113/FAI.2007.0896 PG 6 WC Orthopedics SC Orthopedics GA 197EJ UT WOS:000248537100005 PM 17697654 ER PT J AU Gurusamy, N Malik, G Gorbunov, NV Das, DK AF Gurusamy, Narasimman Malik, Gautam Gorbunov, Nikolai V. Das, Dipak K. TI Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury SO FREE RADICAL BIOLOGY AND MEDICINE LA English DT Article DE Ref-1; NF kappa B; Trx-1; Nrf2; ROS; confocal microscopy ID NF-KAPPA-B; OXIDATIVE STRESS; TRANSCRIPTION FACTOR; FUNCTIONAL-CHARACTERIZATION; CARDIOMYOCYTE APOPTOSIS; IN-VIVO; DNA; REPAIR; NRF2; THIOREDOXIN AB A recent study showed that cardiac adaptation could potentiate translocation of thioredoxin-1 (Trx-1) into the nucleus, which then interacted with Ref-1, resulting in a survival signal. Here, we present evidence that such adaptation also causes nuclear translocation of Ref-1, which is almost completely inhibited when the hearts were pretreated with antisense Ref-1 that also abolished the cardioprotective adaptive response. Significant amounts of NF kappa B and Nrf2 were found to be associated with Ref-1 when the nuclear extract obtained from the left ventricle was immunoprecipitated with Ref-1. Such Ref-1-NF kappa B and Ref-1-Nrf2 interactions were significantly inhibited with antisense Ref-1. However, immunoprecipitation of nuclear extract with NF kappa B showed that the association of Trx-1 with NF kappa B is increased in the adapted heart, which was again significantly blocked by antisense Ref-1. Nrf2 was also associated with NF kappa B; however, such association appeared to be independent of Ref-1. In contrast, myocardial adaptation to ischemia inhibited the ischemia reperfusion-induced loss of Nrf2 from the nucleus, which was inhibited by antisense Ref-1. The nuclear trans location and activation of Ref-1 appeared to generate a survival signal as evidenced by the increased phosphorylation of Akt that was inhibited with antisense Ref-1. Finally, confocal microscopy confirmed the results of immunoblotting, clearly showing the nuclear translocation of Ref-1 and nuclear 3D colocalization of Ref-1 with NF kappa B in the adapted heart and its inhibition with antisense Ref-1. Our results show that PC potentiates a survival signal through the phosphorylation of Akt by causing nuclear translocation and activation of Ref-1, where significant interaction among NF kappa B and Ref-1, Trx-1, and Nrf2 appears to regulate Ref-1 -induced survival signal. (C) 2007 Elsevier Inc. All rights reserved. C1 Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Das, DK (reprint author), Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA. EM DDAS@NEURON.UCHC.EDU FU NHLBI NIH HHS [HL 33889, HL 34360, HL22559] NR 35 TC 26 Z9 27 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0891-5849 J9 FREE RADICAL BIO MED JI Free Radic. Biol. Med. PD AUG 1 PY 2007 VL 43 IS 3 BP 397 EP 407 DI 10.1016/j.freeradbiomed.2007.04.025 PG 11 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 190WH UT WOS:000248090800009 PM 17602955 ER PT J AU Douglas, T Walsh, M Johnson, L McGrath, C Weiss, C Collins, C AF Douglas, T. Walsh, M. Johnson, L. McGrath, C. Weiss, C. Collins, C. TI Geochemical interactions between nitroaromatic (TNT) and nitramine (RDX and HMX) explosives and sediments SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 17th Annual V M Goldschmidt Conference CY AUG, 2007 CL Cologne, GERMANY C1 Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Environm Lab, Vicksburg, MS 39180 USA. Geotech & Struct Lab, Vicksburg, MS 39180 USA. EM Thomas.A.Douglas@erde.usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD AUG PY 2007 VL 71 IS 15 SU S BP A234 EP A234 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 200VC UT WOS:000248789900480 ER PT J AU Harmon, RS Delucia, FC McMillan, NJ Miziolek, AW Whitehouse, A AF Harmon, R. S. Delucia, F. C. McMillan, N. J. Miziolek, A. W. Whitehouse, A. TI LIBS: A new paradigm for real-time and in-field geochemical analysis SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 17th Annual V M Goldschmidt Conference CY AUG, 2007 CL Cologne, GERMANY C1 USA, Res Off, Res Triangle Pk, NC 27709 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21010 USA. New Mexico State Univ, Las Cruces, NM 88003 USA. RI De Lucia, Frank/D-5630-2012 NR 0 TC 0 Z9 0 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD AUG PY 2007 VL 71 IS 15 SU S BP A381 EP A381 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 200VC UT WOS:000248789900773 ER PT J AU Johnson, KP Blum, JD Keeler, GJ Douglas, TA AF Johnson, K. P. Blum, J. D. Keeler, G. J. Douglas, T. A. TI Springtime deposition and emission of mercury from arctic snow SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 17th Annual V M Goldschmidt Conference CY AUG, 2007 CL Cologne, GERMANY C1 Univ Michigan, Ann Arbor, MI 48109 USA. Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. EM kelseyjo@umich.edu; jdblum@umich.edu; jkeeler@umich.edu; Thomas.A.Douglas@erdc.usace.army.mil NR 2 TC 0 Z9 0 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD AUG PY 2007 VL 71 IS 15 SU S BP A449 EP A449 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 200VC UT WOS:000248789901113 ER PT J AU Lyons, WB Harmon, RS Mitasova, H Forizs, I Demeny, A AF Lyons, W. B. Harmon, R. S. Mitasova, H. Forizs, I. Demeny, A. TI Hydrochemistry of four tropical watersheds in central Panama SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 17th Annual V M Goldschmidt Conference CY AUG, 2007 CL Cologne, GERMANY C1 Ohio State Univ, Columbus, OH 43210 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. N Carolina State Univ, Raleigh, NC 27695 USA. Hungarian Acad Sci, Budapest, Hungary. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD AUG PY 2007 VL 71 IS 15 SU S BP A606 EP A606 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 200VC UT WOS:000248789901428 ER PT J AU McManus, CE McMillan, NJ Harmon, RS Delucia, FC Miziolek, AW AF McManus, C. E. McMillan, N. J. Harmon, R. S. Delucia, F. C. Miziolek, A. W. TI LIBS analysis of gem beryls: Single-pulse, double-pulse, and provenance determination SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 17th Annual V M Goldschmidt Conference CY AUG, 2007 CL Cologne, GERMANY C1 New Mexico State Univ, Las Cruces, NM 88003 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21010 USA. EM katedowe@aol.com; nmcmilla@nmsu.edu RI De Lucia, Frank/D-5630-2012 NR 0 TC 0 Z9 0 U1 2 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD AUG PY 2007 VL 71 IS 15 SU S BP A647 EP A647 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 200VC UT WOS:000248789901510 ER PT J AU Wegner, W Worner, G Harmon, RS Simon, K Singer, BS AF Wegner, W. Woerner, G. Harmon, R. S. Simon, K. Singer, B. S. TI Evolution of a maturing arc system: The west-central Isthmus of Panama SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 17th Annual V M Goldschmidt Conference CY AUG, 2007 CL Cologne, GERMANY C1 Univ Gottingen, Abt Geochem, Geowissensch Zentrum Gottingen, D-37077 Gottingen, Germany. USA, Res Off, Div Environm Sci, Res Triangle Pk, NC 27709 USA. Univ Wisconsin, Dept Geol & Geophys, Madison, WI 53706 USA. EM w_wegner@yahoo.de; gwoeme@gwdg.de; russell.harmon@us.army.mil; bsinger@geology.wise.edu NR 2 TC 1 Z9 1 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD AUG PY 2007 VL 71 IS 15 SU S BP A1097 EP A1097 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 200VC UT WOS:000248789902565 ER PT J AU Moore, TJ Kozick, RJ Sadler, BM AF Moore, Terrence J. Kozick, Richard J. Sadler, Brian M. TI The constrained Cramer-Rao round from the perspective of fitting a model SO IEEE SIGNAL PROCESSING LETTERS LA English DT Article DE constrained Cramer-Rao bound (CCRB); equality constraints; model fitting AB Stoica and Ng in [7] presented a simple expression for the constrained Cramer-Rao bound (CCRB) when the constraints are given by a differentiable function of the parameter to be estimated. This letter considers the parallel case in developing the CCRB when the parameters are locally fitted to a lower-dimensional parametric model, i.e., the parameters are locally assumed to be functions of a distinct reduced parameter vector. We employ classical elements of CRB theory on the locally fitted model to present a very simple derivation of the CCRB, conditions for attaining the bound, and a regularity condition. Examples illustrate the key ideas. C1 Army Res Lab, Adelphi, MD 20783 USA. Bucknell Univ, Dept Elect Engn, Lewisburg, PA 17837 USA. RP Moore, TJ (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM tmoore@arl.army.mil; kozick@bucknell.edu; bsadler@arl.army.mil NR 15 TC 12 Z9 12 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1070-9908 J9 IEEE SIGNAL PROC LET JI IEEE Signal Process. Lett. PD AUG PY 2007 VL 14 IS 8 BP 564 EP 567 DI 10.1109/LSP.2006.891316 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA 192WS UT WOS:000248234800015 ER PT J AU O'Brien, H Shaheen, W Bayne, SB AF O'Brien, Heather Shaheen, William Bayne, Stephen B. TI Evaluation of 4 mm x 4 mm silicon carbide thyristors SO IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION LA English DT Article DE thyristors; resistance heating; pulse shaping circuits; pulse power system switches; semiconductor switches; semiconductor materials; semiconductor device breakdown; power semiconductor switches AB The U. S. Army Research Laboratory (ARL) is evaluating silicon carbide thyristors to determine the extent of silicon carbide capabilities as a possible replacement for silicon in future pulsed switching applications. Individual SiC die measuring 4 mm x 4 mm were pulsed at high temperatures and varying pulse widths. At 150 degrees C, these thyristors were switched in an RLC circuit up to 3.2 kA and repetitively pulsed at 2.6 kA and 5 Hz for greater than 14,000 pulses. A pulse forming network (PFN) was designed to increase the pulse width and the action seen by the SiC devices. At ambient temperature and a peak current of 2 kA, SiC thyristors were switched in the PFN at a 50% pulse width of 40 mu s and an action of 150 A(2)s. These devices were also pulsed at narrower pulse widths in pairs to look at their behavior in parallel. One pair reached a peak total current of 6.7 kA with current sharing as good as 51% / 49%. This paper includes further data on the three aforementioned test procedures, as well as analysis of the devices' failure points. C1 USA, Res Lab, Berkeley Res Associates, AMSRD,ARLSE,DP, Adelphi, MD 20783 USA. USA, Res Lab, AMSRD, ARL,SE,DE, Adelphi, MD 20783 USA. RP O'Brien, H (reprint author), USA, Res Lab, Berkeley Res Associates, AMSRD,ARLSE,DP, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 11 TC 7 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1070-9878 J9 IEEE T DIELECT EL IN JI IEEE Trns. Dielectr. Electr. Insul. PD AUG PY 2007 VL 14 IS 4 BP 986 EP 993 DI 10.1109/TDEI.2007.4286538 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 196YY UT WOS:000248520800035 ER PT J AU van der Kruk, J Arcone, SA Liu, L AF van der Kruk, Jan Arcone, Steven A. Liu, Lanbo TI Fundamental and higher mode inversion of dispersed GPR waves propagating in an ice layer SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE dispersion; ground-penetrating radar (GPR); ice; inversion; leaky waveguide; transverse electric (TE); transerse magnetic (TM) ID RAYLEIGH-WAVES; SURFACE; VELOCITY; PULSE AB Dispersion of ground-penetrating radar (GPR) waves can occur when they are trapped in a layer. In this paper, we analyze the modal propagation of GPR pulses through a layer of ice that is overlying water. Dispersed transverse electric (TE) waves that are trapped in the waveguide have larger amplitudes I ban the critically refracted waves that travel through air, whereas the transverse magnetic (TM) critically refracted waves traveling through air are more dominant than the trapped dispersed TM waves. This can be explained by the leaky waveguide behavior of the ice layer. The reflection coefficients for the waves incident on the ice-water interface show that the TM modes are more leaky than the TE modes. Still, clear dispersion is observed in both cases, which depends on the permittivity and thickness of the ice. Similar to inversion of dispersed Rayleigh waves, these parameters can be estimated by calculating phase-velocity spectra, picking dispersion curves, and inverting the dispersion curves using a combined local and global minimization procedure. Synthetic data show several higher order modes of which separate and combined inversions return the input modeling parameters accurately. Experimental data acquired on a frozen lake show strong dispersion for the TE and TM modes. The phase-velocity spectra of the field data show three TE and four TM modes of which separate and combined inversion of different modes return similar values for the ice thickness and known permittivity of ice. Due to the more leaky behavior of the TM modes, the TE inversion is better constrained and more suitable for inversion. C1 ETH, CH-8093 Zurich, Switzerland. ERDC, Cold Regions Res & Engn Lab, Hanover, NH 03755 USA. Univ Connecticut, Storrs, CT 06269 USA. RP van der Kruk, J (reprint author), ETH, CH-8093 Zurich, Switzerland. EM jvdkruk@aug.ig.erdw.ethz.ch RI van der Kruk, Jan/A-5640-2008 OI van der Kruk, Jan/0000-0003-2348-1436 NR 16 TC 26 Z9 26 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD AUG PY 2007 VL 45 IS 8 BP 2483 EP 2491 DI 10.1109/TGRS.2007.900685 PG 9 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 195NO UT WOS:000248419100008 ER PT J AU Ma, LR Cheng, XZ Liu, F An, FG AF Ma, Liran Cheng, Xiuzhen Liu, Fang An, Fengguang TI iPAK: An in situ pairwise key bootstrapping scheme for wireless sensor networks SO IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS LA English DT Article DE wireless sensor networks; in situ key establishment; key predistribution; security AB Wireless Sensor Networks (WSNs) are characterized by resource constraints and large scalability. Many applications of WSNs require secure communication, a crucial component especially in hostile environments. However, the low computational capability and small storage budget within sensors render many popular public-key-based cryptographic systems impractical. Symmetric key cryptography, on the other hand, is attractive due to its efficiency. Nevertheless, establishing a shared key for communicating parties is a challenging problem. In this paper, we propose and analyze an in situ PAirwise Key bootstrapping scheme (iPAK) for large-scale WSNs. Our theoretical analysis and simulation study demonstrate that iPAK can achieve a high key-sharing probability between neighboring sensors and a strong resilience against node-capture attacks at the cost of low storage overhead. C1 George Washington Univ, Dept Comp Sci, Washington, DC 20052 USA. Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China. USA, Chief Informat Off, Architecture Operat Network & Space, Washington, DC USA. RP Ma, LR (reprint author), George Washington Univ, Dept Comp Sci, 801 22nd St NW,Phillips Hall,Suite 720D, Washington, DC 20052 USA. EM lrma@gwu.edu; cheng@gwu.edu; fliu@gwu.edu; anfengguang@software.ict.ac.cn NR 28 TC 12 Z9 12 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1045-9219 EI 1558-2183 J9 IEEE T PARALL DISTR JI IEEE Trans. Parallel Distrib. Syst. PD AUG PY 2007 VL 18 IS 8 BP 1174 EP 1184 DI 10.1109/TPDS.2007.1063 PG 11 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 182ZC UT WOS:000247541500013 ER PT J AU Hoyos, S Sadler, BM AF Hoyos, Sebastian Sadler, Brian M. TI UWB mixed-signal transform-domain direct-sequence receiver SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE analog to digital conversion; broadband wireless communications; direct sequence spread spectrum; ultrawideband communications ID SIGMA-DELTA-MODULATION; CONVERSION; EXPANSION; DESIGN AB We consider a mixed-signal ultra wideband (UWB) direct-sequence spread-spectrum (DS-SS) receiver. The receiver expands the signal over a basis set, and then operates on the basis coefficients. An analog computation of the basis coefficients efficiently parallelizes the signal for digital processing, relaxing the sampling requirements and enabling parallel digital processing at a much lower rate. Bit error rate (BER) performance is evaluated, as well as distortion due to basis truncation. The parallel processing also facilitates efficient interference mitigation. Various models for interference including adjacent multicarrier interference are developed and analyzed. Several simulation results confirm the analysis and provide insight into quantization error, basis truncation distortion, and the impact" of the UWB channel. We show that in the AWGN uncoded case for SNR < 10 dB, the receiver can be operated at almost half the Nyquist rate with only 1 dB of performance loss. Moreover, when a common convolutional code is employed, the aggregate sampling rate can be 37.5 % lower than Nyquist rate with little loss in receiver performance. C1 Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. Army Res Lab, Adelphi, MD 20783 USA. Pontificia Univ Javeriana, Bogota, Colombia. Univ Delaware, Dept Elect & Comp Engn, Newark, DE USA. Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA. Univ Maryland, College Pk, MD 20742 USA. Univ Virginia, Charlottesville, VA USA. Army Res Lab, Adelphi, MD USA. Johns Hopkins Univ, Baltimore, MD 21218 USA. RP Hoyos, S (reprint author), Texas A&M Univ, Dept Elect & Comp Engn, 318G WERC 3128 TAMU, College Stn, TX 77843 USA. EM hoyos@ece.tamu.edu; bsadler@arl.army.mil NR 12 TC 9 Z9 9 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD AUG PY 2007 VL 6 IS 8 BP 3038 EP 3046 DI 10.1109/TWC.2007.051069 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 199BO UT WOS:000248671400035 ER PT J AU Jacoby, GA Davis, NJ AF Jacoby, Grant A. Davis, Nathaniel J., IV TI Mobile host-based intrusion detection and attack identification SO IEEE WIRELESS COMMUNICATIONS LA English DT Article AB Although much attention has focused on optimizing power in batteries for mobile devices, little attention to date has focused on battery constraints to determine if an attack is present. This research proposes that resident monitoring of the demands placed on a battery's current (mA) and other system processes can be used as an early-warning, trip-wire-like sensor for mobile hosts as a means to block attacks as well as to identify them. C1 US Mil Acad, Ctr Informat Technol, New York, NY USA. RP Jacoby, GA (reprint author), US Mil Acad, Ctr Informat Technol, New York, NY USA. EM grant.jacocby@usma.edu; Nathaniel.Davis@afit.edu NR 9 TC 8 Z9 8 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1284 J9 IEEE WIREL COMMUN JI IEEE Wirel. Commun. PD AUG PY 2007 VL 14 IS 4 BP 53 EP 60 DI 10.1109/MWC.2007.4300984 PG 8 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 201KA UT WOS:000248828800010 ER PT J AU Chen, P Cisar, JO Hess, S Ho, JTC Leung, KP AF Chen, Ping Cisar, John O. Hess, Sonja Ho, Jenny T. C. Leung, Kai P. TI Amended description of the genes for synthesis of Actinomyces naeslundii T14V type 1 fimbriae and associated adhesin SO INFECTION AND IMMUNITY LA English DT Article ID GRAM-POSITIVE BACTERIA; VISCOSUS T14V; HYDROXYAPATITE; ADSORPTION; EXPRESSION; STATHERIN; SURFACES; SUBUNIT; PROTEIN; CLONING AB The type 1 fimbriae of Actinomyces naeslundii T14V mediate adhesion of this gram-positive species to the tooth surface. The present findings show that the locus for type 1 timbria production in this strain includes three genes,fimQ for a minor fimbrial subunit that appears to be an adhesin,fimP for the major structural subunit, and srtC1 for a type 1 timbria-specific sortase involved in the assembly of these structures. C1 US Army Dent & Trauma Res Detachment, Walter Reed Army Inst Res, Microbiol Branch, Great Lakes, IL 60088 USA. Natl Inst Dent & Craniofacial Res, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA. Natl Inst Diabet & Digest & Kidney Dis, Proteom & Mass Spectrometry Facil, NIH, Bethesda, MD 20892 USA. RP Leung, KP (reprint author), US Army Dent & Trauma Res Detachment, Walter Reed Army Inst Res, Microbiol Branch, 310B,B St,Bldg 1H, Great Lakes, IL 60088 USA. EM kai.leung@us.army.mil RI Hess, Sonja/K-4842-2013 OI Hess, Sonja/0000-0002-5904-9816 FU Intramural NIH HHS NR 22 TC 15 Z9 18 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 2007 VL 75 IS 8 BP 4181 EP 4185 DI 10.1128/IAI.01955-06 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 194PB UT WOS:000248355200054 PM 17485454 ER PT J AU Shah, MN Devesa, SS Zhu, K McGlynn, KA AF Shah, Mona N. Devesa, Susan S. Zhu, Kangmin McGlynn, Katherine A. TI Trends in testicular germ cell tumours by ethnic group in the United States SO INTERNATIONAL JOURNAL OF ANDROLOGY LA English DT Article; Proceedings Paper CT 6th Copenhagen Workshop on Carcinoma in situ Testis and Germ Cell Cancer CY OCT 26-28, 2006 CL Copenhagen, DENMARK DE testicular cancer; incidence; race; ethnic group; trends ID RISK-FACTORS; INCREASING INCIDENCE; CANCER; TESTIS; CRYPTORCHIDISM; NONSEMINOMA; SEMINOMA; DENMARK; STAGE AB The incidence of testicular germ cell tumours (TGCT) has increased in white and black men in the United States. Little is known, however, about trends among men of other racial/ethnic groups. The current study sought to examine TGCT patterns among men of Asian/Pacific Islander/American Indian/Alaska Native (API/AIAN) and Hispanic ancestries and to determine whether tumours in these groups are diagnosed at comparable stages and sizes to tumours in white and black men. TGCT incidence data and tumour characteristics were drawn from the Surveillance, Epidemiology and End Results registries for two time periods: 1973-2003 and 1992-2003. In 1973-2003, TGCT rates were significantly lower among black (rate ratio = 0.18, p < 0.001) and API/AIAN (rate ratio = 0.37, p < 0.001) men than among white men. Among white and API/AIAN men, rates increased over 60%, mainly prior to 1989-1993. Among black men, rates increased almost 40%, mainly after 1989-1993. Among white and API/AIAN men, increasing proportions of localized disease were diagnosed over time, while the opposite trend was seen among black men. In 1992-2003, TGCT incidence among Hispanic white men (3.46/100 000) was significantly lower than it was among non-Hispanic white men, but rates of both seminoma and non-seminoma increased. While the incidence of TGCT increased among all men, different patterns in the increase were evident. These data suggest that rates are increasing among Hispanic white men and black men, but are stabilizing among white men and API/AIAN men. The peak of the TGCT epidemic may have been reached in these latter groups. C1 Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Natl Inst Hlth, Rockville, MD USA. RP McGlynn, KA (reprint author), NCI, Reprod Epidemiol Branch, DCEG, EPS-5016,6120 Execut Blvd, Rockville, MD 20852 USA. EM mcglynnk@mail.nih.gov FU Intramural NIH HHS NR 21 TC 53 Z9 53 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0105-6263 J9 INT J ANDROL JI Int. J. Androl. PD AUG PY 2007 VL 30 IS 4 BP 206 EP 213 DI 10.1111/j.1365-2605.2007.00795.x PG 8 WC Andrology SC Endocrinology & Metabolism GA 203UC UT WOS:000248998500005 PM 17708751 ER PT J AU Hudas, GR Cheok, KC Overholt, JL AF Hudas, Gregory R. Cheok, Ka. C. Overholt, James L. TI Fuzzy variant of a statistical test point Kalman filter SO INTERNATIONAL JOURNAL OF APPROXIMATE REASONING LA English DT Article; Proceedings Paper CT Annual Conference of the North-American-Fuzzy-Information-Processing-Society CY JUN 22-25, 2005 CL Ann Arbor, MI SP N Amer Fuzzy Informat Proc Soc DE unscented transformation; fuzzy clustering; fuzzy c-means; Gustafson/Kessel; weighted least; squares; covariance; state estimation; parameter estimation AB In this paper, we propose the conceptual use of fuzzy clustering techniques as iterative spatial methods to estimate a posteriori statistics in place of the weighted averaging scheme of the Unscented Kalman filter. Specifically, instead of a linearization methodology involving the statistical linear regression of the process and measurement functions through some deterministically chosen set of test points (sigma points) contained within the "uncertainty region" around the state estimate, we present a variant of the Unscented transformation involving fuzzy clustering techniques which will be applied to the test points yielding "degrees of membership" in which Gaussian shapes can be "fit" using a least squares scheme. Implementation into the Kalman methodology will be shown along with simple state and parameter estimation examples. (c) 2006 Elsevier Inc. All rights reserved. C1 USA, RDECOM TARDEC, AMSRD TAR R, Warren, MI 48397 USA. Oakland Univ, Dept Elect & Syst Engn, Rochester, MI 48309 USA. RP Hudas, GR (reprint author), USA, RDECOM TARDEC, AMSRD TAR R, Bldg 200C,Mailstop 263,6501 E 11 Mile Rd, Warren, MI 48397 USA. EM greg.hudas@us.arniy.mil; cheok@oakiand.edu; jim.overholt@us.army.mil NR 19 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0888-613X J9 INT J APPROX REASON JI Int. J. Approx. Reasoning PD AUG PY 2007 VL 45 IS 3 BP 455 EP 469 DI 10.1016/j.ijar.2006.06.021 PG 15 WC Computer Science, Artificial Intelligence SC Computer Science GA 203RA UT WOS:000248990500004 ER PT J AU Shaffer, DN Bautista, CT Sateren, WB Sawe, FK Kiplangat, SC Miruka, AO Renzullo, PO Scott, PT Robb, ML Michael, NL Birx, DL AF Shaffer, Douglas N. Bautista, Christian T. Sateren, Warren B. Sawe, Frederick K. Kiplangat, Stanley C. Miruka, Argwings O. Renzullo, Philip O. Scott, Paul T. Robb, Merlin L. Michael, Nelson L. Birx, Deborah L. TI The protective effect of circumcision on HIV incidence in rural low-risk men circumcised predominantly by traditional circumcisers in Kenya - Two-year follow-up of the Kericho HIV Cohort Study SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article; Proceedings Paper CT 16th International AIDS Conference CY AUG 13-18, 2006 CL Toronto, CANADA DE circumcision; HIV; Kenya; low risk; male; rural ID IMMUNODEFICIENCY-VIRUS TYPE-1; SUB-SAHARAN AFRICA; PREVENTION; ACCEPTABILITY; TRANSMISSION; INFECTIONS; HIV/AIDS; TRIAL AB Background: Three randomized controlled trials (RCTs) have demonstrated that mate circumcision prevents female-to-male HIV transmission in sub-Saharan Africa. Data from prospective cohort studies are helpful in considering generalizability of RCT results to populations with unique epidemiologic/cultural characteristics. Methods: Prospective observational cohort sub-analysis. A total of 1378 men were evaluated after 2 years of follow-up. Baseline sociodemographic and behavioral/HIV risk characteristics were compared between 270 uncircumcised and 1108 circumcised men. HIV incidence rates (per 100 person-years) were calculated, and Cox proportional hazards regression analyses estimated hazard rate ratios (HRs). Results: Of the men included in this study, 80.4 % were circumcised; 73.9 % were circumcised by traditional circumcisers. Circumcision was associated with tribal affiliation, high school education, fewer marriages, and smaller age difference between spouses (P < 0,05). After 2 years of follow-up, there were 30 HIV incident cases (17 in circumcised and 13 in uncircumcised men). Two-year HIV incidence rates were 0.79 (95% confidence interval [CI]: 0.46 to 1.25) for circumcised men and 2.48 (95% CI: 1.33 to 4.21) for uncircumcised men corresponding to a HR = 0.31 (95% CI: 0.15 to 0.64). In one model controlling for sociodemographic factors, the HR increased and became non-significant (HR =0.55; 95% CI: 0.20 to 1.49). Conclusions: Circumcision by traditional circumcisers offers protection from HIV infection in adult men in rural Kenya. Data from well-designed prospective cohort studies in populations with unique cultural characteristics can supplement RCT data in recommending public health policy. C1 Walter Reed Project HIV Program, US Army Med Res Unit, Kericho, Kenya. Henry M Jackson Fdn Advancement Mil Med Inc, Rockville, MD USA. Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD USA. Kenya Govt Med Res Ctr, Kericho, Kenya. NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. US Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA. RP Shaffer, DN (reprint author), Walter Reed Project HIV Program, US Army Med Res Unit, Kericho, Kenya. EM dshaffer@wrp-kch.org RI Bautista, Christian/B-2812-2011 NR 22 TC 21 Z9 22 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD AUG 1 PY 2007 VL 45 IS 4 BP 371 EP 379 DI 10.1097/QAI.0b013e318095a3da PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 189ZS UT WOS:000248028100001 PM 17558336 ER PT J AU Larsen, ML AF Larsen, Michael L. TI Spatial distributions of aerosol particles: Investigation of the Poisson assumption SO JOURNAL OF AEROSOL SCIENCE LA English DT Article DE aerosol spatial distribution; Poisson statistics; concentration fluctuations; variance/mean ratio; pair-correlation function ID FLUCTUATION PROPERTIES; TURBULENT FLOWS; CLOUDS; PRECIPITATION; RAIN AB Atmospheric particulates are known to be distributed non-uniformly in space due to spatially localized sources and incomplete mixing. Many studies have extensively examined the variability of aerosol particle concentrations on diurnal, seasonal, and annual timescales. Receiving much less attention, however, are aerosol particle spatial distributions on shorter (less than or similar to 5 min) temporal scales. Knowledge regarding the spatial distribution on these temporal scales is vital to fully understand and predict the properties of microphysical processes like activation, coagulation, and collision/coalescence, as well as some large-scale phenomena like radiation attenuation through a thick yet dilute layer of particles. Traditional treatments of microphysical phenomena often implicitly assume that particles are perfectly randomly distributed (obey Poisson statistics) on short temporal scales, even though this assumption may be inconsistent with observations made on longer scales. This study seeks to explicitly resolve the statistics of particle positions on a variety of temporal scales (over five orders of magnitude) to determine if and when the assumption of perfect spatial randomness can be justified in nature. Some implications of the results are discussed. (c) 2007 Elsevier Ltd. All rights reserved. C1 Univ Nebraska, Dept Phys & Phys Sci, Kearney, NE 68849 USA. Army Res Lab, Battlefield Environm Div, Atmospher Sensing Branch, Adelphi, MD USA. RP Larsen, ML (reprint author), Univ Nebraska, Dept Phys & Phys Sci, Kearney, NE 68849 USA. EM LarsenML@gmail.com NR 33 TC 9 Z9 9 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0021-8502 J9 J AEROSOL SCI JI J. Aerosol. Sci. PD AUG PY 2007 VL 38 IS 8 BP 807 EP 822 DI 10.1016/j.jaerosci.2007.06.007 PG 16 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 214NN UT WOS:000249745300002 ER PT J AU Bried, JT Herman, BD Ervin, GN AF Bried, Jason T. Herman, Brook D. Ervin, Gary N. TI Umbrella potential of plants and dragonflies for wetland conservation: a quantitative case study using the umbrella index SO JOURNAL OF APPLIED ECOLOGY LA English DT Article DE conservation; odonata; umbrella index; umbrella potential; umbrella schemes; umbrella species; vascular plants; wetlands ID SPECIES-RICHNESS; RESERVE SELECTION; TAXONOMIC GROUPS; INDICATOR GROUPS; SOUTH-AFRICA; DIVERSITY; ODONATA; BIODIVERSITY; ASSEMBLAGES; MANAGEMENT AB 1. Shortcuts to measuring biodiversity enable prioritization of conservation effort in the face of limited time, personnel and funding. The conservation umbrella approach focuses management effort according to individual species that may confer protection to a larger community. This approach can help guide the management agenda towards attainable goals by maximizing conservation returns per unit effort. The development of the umbrella index has shown promise in identifying umbrella species in terrestrial ecosystems but has received little attention with respect to the management of wetland ecosystems. 2. We used the umbrella index to assess the umbrella potential of vascular plants and dragonflies (Odonata) from 15 wetland impoundments in northern Mississippi, USA. The presence of adult odonates was determined by repeated visual surveys and plant lists were compiled from 50 plots per site. 3. Umbrella schemes, or the sites occupied by top umbrella species, missed large numbers of beneficiary species and occurrences. With one exception, umbrella schemes failed to optimize conservation returns relative to randomized schemes in both assemblages. Also, umbrella schemes approximately equalled the performance of non-umbrella schemes both overall and for species with a low rate of occurrence. Low occurrence rates in both assemblages may have hindered umbrella index performance because the index assumes that species with moderate occurrence rates have the most umbrella potential. 4. Cross-taxon analyses (Mantel tests and McNemar tests) suggested transferability of plant and dragonfly umbrella schemes, and non-random association between the plants and dragonflies in these wetlands. 5. Synthesis and applications. Despite the questionable performance of umbrella schemes in our study, the use of a quantitative ecological tool such as the umbrella index instead of political or popularity criteria is strongly recommended for future selection of umbrella species. The results of cross-taxon analyses supported growing evidence for spatial and functional relationships between wetland macrophytes and adult odonates. We suggest that the more easily measured assemblage can be used to set priorities for wetland conservation planning in circumstances where human resources are constrained. C1 US Army Corps Engn, Chicago Dist, Chicago, IL 60606 USA. Mississippi State Univ, Dept Biol Sci, Mississippi State, MS 39762 USA. RP Bried, JT (reprint author), Nat Conservancy Eastern New York Conservat Off, Albany Pine Bush Preserve Commiss, 195 New Karner Rd, Albany, NY 12205 USA. EM jbried@tnc.org NR 62 TC 24 Z9 27 U1 5 U2 32 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0021-8901 J9 J APPL ECOL JI J. Appl. Ecol. PD AUG PY 2007 VL 44 IS 4 BP 833 EP 842 DI 10.1111/j.1365-2664.2007.01299.x PG 10 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 184UC UT WOS:000247667100013 ER PT J AU Murphy, CE Hoover, JJ George, SG Killgore, KJ AF Murphy, C. E. Hoover, J. J. George, S. G. Killgore, K. J. TI Morphometric variation among river sturgeons (Scaphirhynchus spp.) of the Middle and Lower Mississippi River SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article; Proceedings Paper CT Conference on Evolution, Ecology, and Management of Scaphirhynchus CY JAN 11-13, 2005 CL St Louis, MO ID SHOVELNOSE STURGEON; SEQUENCES; MISSOURI AB Pallid sturgeon (Scaphirhynchus albus) captured in the Middle and Lower Mississippi River (i.e. below St. Louis, MO, USA) are morphologically very similar to shovelnose sturgeon (Scaphirhynchus platorynchus). Available empirical data are limited to a few studies based on low sample sizes from disjointed populations. Geneticists are currently searching for markers that will differentiate the two species, but the need for unequivocal species- specific field characters remains. Continuation of commercial fishing for shovelnose sturgeon in some states necessitates an immediate means for accurate field identifications. Previous studies of lower basin river sturgeon classified individuals with simple morphometric character indices and interpreted intermediacy as interspecific hybridization. In this study, morphometric variation among Scaphirhynchus specimens from the Middle and Lower Mississippi River is examined for evidence of hybridization. Data are compared for large (>250-mm standard length) hatcheryreared and wild pallid specimens and wild shovelnose specimens. Specimens are compared using two morphometric character indices, two morphometric/meristic character indices and principal components analysis. Results indicate substantial morphological variation among pallid sturgeon below the mouth of the Missouri River. The amount of variation appears to decrease downstream in the Mississippi River. Sheared principal components analysis of morphometric data shows complete separation of shovelnose and pallid sturgeon specimens whereas character indices indicate overlap. Both character indices and sheared principal components analysis demonstrate that pallid sturgeon in the Lower Mississippi River are morphologically more similar to shovelnose sturgeon than are pallids from the Upper Missouri River. This similarity, explained in previous studies as hybridization may be the result of latitudinal morphometric variation Q length-at-age differences between populations of the upper and lower extremes of the range. C1 USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Murphy, CE (reprint author), USA, Corps Engineers, Ctr Res Dev & Engn, 3909 Halls Ferry Rd,EE-A, Vicksburg, MS 39180 USA. EM cmurphy@jayacorp.com NR 34 TC 26 Z9 26 U1 1 U2 6 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD AUG PY 2007 VL 23 IS 4 BP 313 EP 323 DI 10.1111/j.1439-0426.2007.00883.x PG 11 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 200IC UT WOS:000248756100005 ER PT J AU Murphy, CE Hoover, JJ George, SG Lewis, BR Killgore, KJ AF Murphy, C. E. Hoover, J. J. George, S. G. Lewis, B. R. Killgore, K. J. TI Types and occurrence of morphological anomalies in Scaphirhynchus spp. of the Middle and Lower Mississippi River SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article; Proceedings Paper CT Conference on Evolution, Ecology, and Management of Scaphirhynchus CY JAN 11-13, 2005 CL St Louis, MO ID NORTH-AMERICAN STURGEONS AB Sturgeon specimens encountered in the wild that exhibit visible signs of gross physical trauma often took to the naked eye to be in otherwise good condition. Visible morphological anomalies were observed in 9.1% of 176 pallid (Scaphirhvnchus albus) and 4.6% of 4904 shovelnose (Scaphirhynchus platorynchus) sturgeon specimens captured in the Middle (mouth of Missouri River to mouth of Ohio River) and Lower (below mouth of Ohio River) Mississippi River from 1997 to 2004. Frequencies among the types of anomalies differed between the lower and middle river reaches. In the lower river, deformities from foreign objects (typically rubber bands) comprised almost one-third of anomalies observed and may have contributed to other types of anterior injury which, if combined, would comprise the majority of lower river anomalies. In the middle river, nearly half of the observed anomalies involved damage to the caudal peduncle, usually a missing tail. Power regressions from length-weight relationships were compared for anomalous and non-anomalous specimens and demonstrated no significant disparity, verifying the resiliency of river sturgeons. C1 USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Murphy, CE (reprint author), USA, Corps Engineers, Ctr Res Dev & Engn, 3909 Halls Ferry Rd,EE-A, Vicksburg, MS 39180 USA. EM cmurphy@jayacorp.com NR 12 TC 4 Z9 4 U1 0 U2 3 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD AUG PY 2007 VL 23 IS 4 BP 354 EP 358 DI 10.1111/j.1439-0426.2007.00882.x PG 5 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 200IC UT WOS:000248756100008 ER PT J AU Allen, TC Phelps, QE Davinroy, RD Lamm, DM AF Allen, T. C. Phelps, Q. E. Davinroy, R. D. Lamm, D. M. TI A laboratory examination of substrate, water depth, and light use at two water velocity levels by individual juvenile pallid (Scaphirhynchus albus) and shovelnose (Scaphirhynchus platorynchus) sturgeon SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article; Proceedings Paper CT Conference on Evolution, Ecology, and Management of Scaphirhynchus CY JAN 11-13, 2005 CL St Louis, MO ID UPPER MISSISSIPPI RIVER; HABITAT USE; MOVEMENTS; MISSOURI; BIOLOGY AB We investigated the influence of substrate type, water depth, light, and relative water velocity on microhabitat selection in juvenile pallid (Scaphirhynchus albus) and shovelnose (Scaphirhynchus platorynchus) sturgeon. Individual sturgeon were placed in an 18 927 L elliptical flume, and their location was recorded after a 2-h period. Data were analyzed using exact chi-square goodness of fit tests and exact tests of independence. Both sturgeon species used substrate, depth, and light in similar proportions. (all comparisons; P > 0.05). Specifically, pallid and shovelnose sturgeon did not use substrate in proportion to its availability (pallid: P = 0.0026; shovelnose: P = 0.0199). Each species used sand substrate more and gravel substrate less than expected based on availability. Additionally, neither species used woody structure. Both species used deep areas in greater proportion than availability while shallow areas were used less than expected based on availability (pallid-, P < 0.0001; shovelnose; P = 0.0335). Pallid and shovelnose sturgeon used very dark areas in greater proportion than expected based on availability; however, very light areas were used in lower proportion than expected (P < 0.0001). Overall, neither species changed their use of habitat in relation to a change in water velocity (pallid, all comparisons P > 0.05; shovelnose, all comparisons P > 0.05). This study is the first investigation of juvenile pallid and shovelnose sturgeon habitat selection in a large-scale artificial stream system. Field studies of microhabitat selection by juvenile pallid and shovelnose sturgeon should be carried out to substantiate the results of this study, and to identiy critical habitat for recovery and management of sturgeon species. Due to the extensive range, longevity, and migratory behavior of these fishes, proper management likely requires river improvements that provide sturgeon with access to a broad range of habitat conditions over time, including system-wide habitat diversity; natural variation in flow, velocity, temperature, and turbidity; high water quality; a broad prey base; free-flowing river sections which provide suitable spawning and rearing sites, as well as protection from recreational and commercial harvesting. C1 USA, Corps Engineers, St Louis, MO 63103 USA. So Illinois Univ, Fisheries & Illinois Aquaculture Ctr, Carbondale, IL 62901 USA. USA, Corps Engineers, Appl River Engn Ctr, St Louis, MO USA. RP Allen, TC (reprint author), USA, Corps Engineers, St Louis Dist,CEMVS PM E,1222 Spruce St, St Louis, MO 63103 USA. EM teri.c.allen@mvs02.usace.army.mil NR 26 TC 7 Z9 10 U1 1 U2 16 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD AUG PY 2007 VL 23 IS 4 BP 375 EP 381 DI 10.1111/j.1439-0426.2007.00895.x PG 7 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 200IC UT WOS:000248756100011 ER PT J AU Killgore, KJ Hoover, JJ Kirk, JP George, SG Lewis, BR Murphy, CE AF Killgore, K. J. Hoover, J. J. Kirk, J. P. George, S. G. Lewis, B. R. Murphy, C. E. TI Age and growth of pallid sturgeon in the free-flowing Mississippi River SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article; Proceedings Paper CT Conference on Evolution, Ecology, and Management of Scaphirhynchus CY JAN 11-13, 2005 CL St Louis, MO ID PECTORAL FIN RAYS; SHOVELNOSE STURGEON; SCAPHIRHYNCHUS-ALBUS; MISSOURI AB Trotlines were used to capture pallid sturgeon in the free-flowing Mississippi River, which extends from the Gulf of Mexico to the mouth of the Missouri River. Trotlines were baited with worms, and set overnight usually along the channel border. The pectoral fin rays of 165 pallid sturgeon caught in the Mississippi River were aged; 118 were from the lower Mississippi River (LMR) between the Gulf and mouth of the Ohio River, and 47 were from the middle Mississippi River (MMR) between the mouths of the Ohio and Missouri rivers. Initial agreement within I year between two readers ranged from 53% for the LMR specimens, which were read first, to 84% for the MMR. Final age was agreed upon by both readers. For LMR pallid sturgeon, final age estimates ranged from 3 to 21 years with a mean (+/- SD) of 11.0 +/- 4.7. For MMR pallid sturgeon, final age estimates ranged from 5 to 14 years with a mean of 9.5 +/- 2. 1. Seven pallid sturgeon marked with coded wire tags (CWT), indicating hatchery origin, were collected in the MMR. Age estimates for CWT fish were 7-8 years representing 1997 stocked fish, and 11-12 years representing 1992 progeny stocked in 1994. Von Bertalanffy growth equations for length indicated that pallid sturgeon in the MMR had higher growth rates for a given age than pallid sturgeon in the LMR. However, there were no significant differences (ANOVA, P > 0.5) in the length-weight relationships between reaches. In the LMR, pallid sturgeon fully recruited to trotlines at age I I and instantaneous total mortality (Z; slope of catch curve) was estimated at -0. 12 (n = 10 year classes, r(2) = 0.55,P = 0.01). Of the 118 sectioned rays from the LMR, 28 could not be reliably aged (only one section from the MMR could not be aged). Therefore, age was predicted from length using the von Bertalanffy equation. The catch curve was re-calculated using the predicted ages of the 28 pallid sturgeon in the LMR resulting in Z = -0.07. In the MMR, pallid sturgeon fully recruited to trotlines at age 9 and Z was estimated at -0.36 (n = 6 year classes, r(2) = 0.67, P - 0.04), which was significantly higher (ANOVA, P = 0.04) than the LMR estimate. Higher mortality in the MMR may be due to habitat limitations compared to a larger, more diverse channel in the LMR, and incidental take of larger, older individuals during commercial harvesting of shovelnose sturgeon. Commercial take of shovelnose does not occur in the LMR except in the northern portion of the reach. Considering the presence of pallid sturgeon with CWT, recruitment of older individuals in the MMR may have been influenced by stocking a decade earlier. Management strategies for this endangered species should consider the differences in mortality rates among reaches, the impacts of commercial fishing on recovery of pallid sturgeon in the MMR, and the long-term effects of hatchery fish now recruiting into the free-flowing Mississippi River. C1 USA, Ctr Res Dev & Engn, Environm Lab, Vicksburg, MS 39180 USA. RP Killgore, KJ (reprint author), USA, Ctr Res Dev & Engn, Environm Lab, 3909 Halls Ferry Rd,EE-A, Vicksburg, MS 39180 USA. EM jack.kiligore@erdc.usace.army.mil NR 23 TC 29 Z9 32 U1 0 U2 11 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD AUG PY 2007 VL 23 IS 4 BP 452 EP 456 DI 10.1111/j.1439-0426.2007.00892.x PG 5 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 200IC UT WOS:000248756100019 ER PT J AU Killgore, KJ Hoover, JJ George, SG Lewis, BR Murphy, CE Lancaster, WE AF Killgore, K. J. Hoover, J. J. George, S. G. Lewis, B. R. Murphy, C. E. Lancaster, W. E. TI Distribution, relative abundance and movements of pallid sturgeon in the free-flowing Mississippi River SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article; Proceedings Paper CT Conference on Evolution, Ecology, and Management of Scaphirhynchus CY JAN 11-13, 2005 CL St Louis, MO ID SCAPHIRHYNCHUS-ALBUS; SHOVELNOSE STURGEON; YELLOWSTONE RIVERS; HABITAT USE; MISSOURI; MODELS AB A multiyear study of pallid sturgeon distribution and relative abundance was conducted in the lower and middle Mississippi river (LMR and MMR, respectively). The LMR and MMR comprise the free-flowing Mississippi River extending 1857 river kilometers (rkm from its mouth at the Gulf of Mexico upstream to the mouth of the Missouri River. A total of 219 pallid sturgeon and 6018 shovelnose sturgeon was collected during the periods 1996-1997 and 2000-2006. Trotlines baited with Worms were the primary collecting gear. The smallest pallid Sturgeon captured on trotlines was 405 turn FL and the largest was 995 turn FL. Mean size of pallid sturgeon was statistically smaller in the Mississippi River below the Atchafalaya River near Baton Rouge, LA (621 turn FL). Mean abundance (catch per trotline night) of pallid sturgeon was highest at water temperatures around 10 degrees C. There was a latitudinal trend in mean abundance of pallid and shovelnose sturgeon, but the pattern differed between species. Pallid sturgeon abundance was statistically (P < 0.05) higher (0.3 fish per trotline night) in the lower reach between the Atchafalaya River and New Orleans (rkm 154-507), and at the Chain of Rocks (COR), a low water dam near the mouth of the Missouri River. Pallid sturgeon abundance between these two locations was statistically the same (0.12-0.23). Shovelnose sturgeon abundance increased going upstream, but was disproportionally higher at the COR (22 fish per line compared with < 6 fish per line in other reaches). Overall, the ratio between pallid and shovelnose sturgeon varied from a high of 1 : 6 at the lower reach, and gradually decreased upstream to a low of 1 : 77 at the COR. Based on differences in sturgeon abundance, size and habitat characteristics, the free-flowing Mississippi River can be divided into two reaches in the MMR (i.e. COR is a separate location), and four reaches (i.e., including the Atchafalaya River) in the LMR where management goals may differ. C1 USA, Ctr Res Dev & Engn, Environm Lab, Vicksburg, MS 39180 USA. RP Killgore, KJ (reprint author), USA, Ctr Res Dev & Engn, Environm Lab, 3909 Halls Ferry Rd,EE-A, Vicksburg, MS 39180 USA. EM jack.killgore@erdc.usace.army.mil NR 36 TC 25 Z9 27 U1 0 U2 12 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD AUG PY 2007 VL 23 IS 4 BP 476 EP 483 DI 10.1111/j.1439-0426.2007.00891.x PG 8 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 200IC UT WOS:000248756100022 ER PT J AU Hoover, JJ George, SG Killgore, KJ AF Hoover, J. J. George, S. G. Killgore, K. J. TI Diet of shovelnose sturgeon and pallid sturgeon in the free-flowing Mississippi River SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article; Proceedings Paper CT Conference on Evolution, Ecology, and Management of Scaphirhynchus CY JAN 11-13, 2005 CL St Louis, MO AB Gut contents of shovelnose and pallid sturgeon from the lower and middle Mississippi River were obtained by colonic flushing, a safe and easily implemented alternative to gastric lavage. Diets of both species were dominated numerically by immature Trichoptera, Ephemeroptera, and Diptera. Primary prey, based on volume, for shovelnose sturgeon were Trichoptera, and for pallid sturgeon were various fishes. Geographic and seasonal nuances in diet were observed for both species, but the general dichotomy of shovelnose sturgeon as browser on invertebrates and pallid sturgeon as predator on fishes did not change. Data indicate that both species require hard substrates for feeding. Data demonstrate that colonic flushing is an effective technique for describing diet and inferring ecological and behavioral information about sturgeon. C1 USA, Ctr Res Dev & Engn, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Hoover, JJ (reprint author), USA, Ctr Res Dev & Engn, Waterways Expt Stn, Vicksburg, MS 39180 USA. EM jan.j.hoover@erdc.usace.army.mil NR 21 TC 23 Z9 26 U1 1 U2 11 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD AUG PY 2007 VL 23 IS 4 BP 494 EP 499 DI 10.1111/j.1439-0426.2007.00893.x PG 6 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 200IC UT WOS:000248756100025 ER PT J AU Keevin, TM George, SG Hoover, JJ Kuhajda, BR Mayden, RL AF Keevin, T. M. George, S. G. Hoover, J. J. Kuhajda, B. R. Mayden, R. L. TI Food habits of the endangered Alabama Sturgeon, Scaphirhynchus suttkusi Williams and Clemmer, 1991 (Acipenseridae) SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article; Proceedings Paper CT Conference on Evolution, Ecology, and Management of Scaphirhynchus CY JAN 11-13, 2005 CL St Louis, MO ID SHOVELNOSE STURGEON; MISSOURI RIVER; BEHAVIOR; PLATORYNCHUS; TAXONOMY; FISHES AB The gut contents of 12 museum specimens of the federally (USA) endangered Alabama sturgeon were analyzed. This collective series represents 32% of the known Museum specimens. Gut contents were dominated by aquatic insects and fishes. At the taxonomic level of insect orders, Dipterans (174.3/fish) were the most numerically abundant food item consumed, followed by Ephemeroptera (19.0/fish), Trichoptera (4.0/fish), Coleoptera (2.4/fish), and Odonata (2.0/fish). Weight, which better reflects the caloric value of food items consumed, showed a similar consumption pattern. Dipterans (12.5%) made up the largest percentage of the total weight of insect prey, followed by Ephemeroptera (8.9%), Trichoptera (6.0%), Odonata, (4.5%) and Coleoptera (0.9%). Volumetric values were substantially higher than weights for Odonata (13.4%) and Ephemeroptera (14.3%), but were comparable for Diptera (10.6%), Trichoptera (4.7%), and Coleoptera (2.2%). The diet of the Alabama sturgeon is similar to the pallid and shovelnose sturgeon, eating both aquatic invertebrates and fish. In terms of piscivory, the volume of fish in the diet of the Alabama sturgeon (34.5%) is intermediate between that of the shovelnose (0% fish) and the pallid sturgeon (60% fish). Based upon the habitat preference of the prey family assemblages present from the 12 guts examined, probable feeding habitats of this sturgeon include sandy to rocky bottoms, slow to swift water velocities, and the water column. Conservation of fish prey may be important to the survival and recovery of the Alabama sturgeon. C1 US Army Corps Engn, Environm Branch, St Louis, MO 63103 USA. US Corp Engn, Engn Res & Dev Ctr, Vicksburg, MS USA. Univ Alabama, Dept Sci Biol, Tuscaloosa, AL USA. St Louis Univ, Dept Biol, St Louis, MO 63103 USA. RP Keevin, TM (reprint author), US Army Corps Engn, Environm Branch, St Louis Dist,1222 Sprice St, St Louis, MO 63103 USA. EM thomas.m.keevin@mvs02.usace.army.mil NR 40 TC 4 Z9 4 U1 0 U2 6 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0175-8659 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD AUG PY 2007 VL 23 IS 4 BP 500 EP 505 DI 10.1111/j.1439-0426.2007.00906.x PG 6 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 200IC UT WOS:000248756100026 ER PT J AU Cole, MW Ngo, E Hirsch, S Demaree, JD Zhong, S Alpay, SP AF Cole, M. W. Ngo, E. Hirsch, S. Demaree, J. D. Zhong, S. Alpay, S. P. TI The fabrication and material properties of compositionally multilayered Ba1-xSrxTiO3 thin films for realization of temperature insensitive tunable phase shifter devices SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PULSED-LASER-DEPOSITION; PLANAR DIELECTRIC-PROPERTIES; STRONTIUM-TITANATE FILMS; SOL-GEL TECHNIQUE; MICROWAVE APPLICATIONS; ELECTRICAL CHARACTERISTICS; EPITAXIAL-GROWTH; HIGH TUNABILITY; GRADED (BA; CAPACITORS AB Compositionally layered BaxSr1-xTiO3 (Ba0.60Sr0.40TiO3-Ba0.75Sr0.25TiO3-Ba0.90Sr0.10TiO3) 220 nm thin film heterostructures were fabricated on Pt coated high resistivity Si substrates via the metal organic solution deposition technique (MOSD). Optimization of the material design was achieved by evaluating two integration schemes, namely, the single- and multianneal process protocols. Materials characterization demonstrated that both film process protocols resulted in smooth, dense, crack-free films with a single phase perovskite structure. Rutherford backscattering spectroscopy revealed compositionally distinct layers and severe elemental interdiffusion for the films fabricated via the multianneal and single-anneal process protocols, respectively. The retention of the compositional layering subsequent to film crystallization deemed the multianneal processed BaxSr1-xTiO3 (BST) film suitable for evaluation of dielectric properties. The dielectric properties were compared to both paraelectric uniform composition BST and to the relevant compositionally graded BST films reported in the technical literature. Our results made evident that the multiannealed compositionally layered BST films possessed higher permittivity (epsilon(r)=360) and lower dissipation factor (tan delta=0.012) with respect to both uniform composition paraelectrie Ba0.60Sr0.40TiO3 film fabricated via the same MOSD processing method and the relevant literature values for compositionally graded BST films. The multilayered BST material design exhibited minimal dielectric dispersion in the range of 90 to - 10 degrees C, showing a 6.4% decrease in permittivity (corresponding to a temperature coefficient of capacitance TCC20-90=-0.921) as the temperature was elevated from 20 to 90 degrees C and only a 2.1 increase in permittivity (TCC20-(-10)=-0.716) as the temperature was lowered from 20 to -10 degrees C. Additionally, the dielectric tunability of the multilayered BST structures over the temperature range of -10-90 degrees C was temperature independent. Our results show that the multilayered BST design has excellent dielectric properties and the enhanced tunability and dielectric loss are stable over a relatively broad temperature range of -10-90 degrees C, thereby making them excellent candidates for the next generation of enhanced performance temperature stable tunable devices. (c) 2007 American Institute of Physics. C1 Univ Connecticut, CMBE Dept, Mat Sci & Engn Program, Storrs, CT 06269 USA. Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Cole, MW (reprint author), Univ Connecticut, CMBE Dept, Mat Sci & Engn Program, Storrs, CT 06269 USA. EM mcole@arl.army.mil; p.alpay@ims.uconn.edu RI Alpay, Pamir/E-2666-2013 NR 45 TC 69 Z9 71 U1 3 U2 39 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 2007 VL 102 IS 3 AR 034104 DI 10.1063/1.2761849 PG 11 WC Physics, Applied SC Physics GA 207GW UT WOS:000249240600074 ER PT J AU Fleming, I Fulton, CC Lucovsky, G Rowe, JE Ulrich, MD Luning, J AF Fleming, I. Fulton, C. C. Lucovsky, G. Rowe, J. E. Ulrich, M. D. Luening, J. TI Local bonding analysis of the valence and conduction band features of TiO2 SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID 110 SURFACES; PHOTOEMISSION; TRANSITION; OXIDES; STATES; SPECTROSCOPY; RUTILE AB An analysis of the valence and conduction band electronic structure of TiO2 as studied by ultraviolet photoemission spectroscopy (UPS) and x-ray absorption spectroscopy (XAS) using synchrotron radiation is reported. Valence band spectra from UPS have been deconvolved using a five-peak model. The spectra are interpreted based on the peak assignments to the XAS data and the symmetries of the valence band states. The interpretation is consistent with theoretical calculations of molecular orbitals found in the literature. The removal of the d-state degeneracies that arise from a collective Jahn-Teller splitting of the crystal field Split t(2g) and e(g) states is observed and scales with the conduction band results from the absorption data. These Jahn-Teller derived energy separations are present in the O K-1, and Ti L-3 spectra but are not resolved in the photoemission valence band spectra. Two defect states are clearly observed similar to 0.7 and 2.0 eV above the valence band edge and are attributed to the presence of oxygen atom vacancies that are described in terms of Ti3+ states. (c) 2007 2007. C1 N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. Div Phys, Army Res Off, Res Triangle Pk, NC 27709 USA. Stanford Univ, Stanford Synchrotron Radiat Lab, Menlo Pk, CA USA. RP Fleming, I (reprint author), N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. EM lbflemin@unity.nesu.edu NR 32 TC 2 Z9 2 U1 3 U2 27 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 2007 VL 102 IS 3 AR 033707 DI 10.1063/1.2764004 PG 7 WC Physics, Applied SC Physics GA 207GW UT WOS:000249240600045 ER PT J AU Hackley, JC Gougousi, T Demaree, JD AF Hackley, Justin C. Gougousi, Theodosia Demaree, J. Derek TI Nucleation of HfO2 atomic layer deposition films on chemical oxide and H-terminated Si SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID GATE DIELECTRIC LAYERS; ZIRCONIUM-OXIDE; HAFNIUM OXIDE; THIN-FILMS; SILICON; GROWTH; METAL; ADSORPTION; DIFFUSION; DENSITY AB HfO2 thin films have been deposited by an atomic layer deposition (ALD) process using alternating pulses of tetrakis-ethylmethylamino hafnium and H2O precursors at 250 degrees C. The as-deposited films are mainly amorphous and nearly stoichiometric HfO2 (O/Hf ratio similar to 1.9) with low bonded carbon content (similar to 3 at. %). A comparison of the nucleation stage of the films on OH- and H-terminated Si(100) surfaces has been performed using Rutherford backscattering spectrometry, x-ray photoelectron spectroscopy (XPS), and spectroscopic ellipsometry (SE). We find for the initial 5-7 process cycles that the film nucleates more efficiently on the OH-terminated surface. However, after the 7th cycle both surfaces exhibit similar surface coverage, which takes about 40 cycles to reach a steady growth rate per cycle. Angle resolved XPS measurements reveal the formation of a similar to 6 angstrom interfacial layer after four ALD cycles on the H-terminated surface and the thickness of the interfacial layer does not change substantially between the 4th and the 50th process cycles as shown by transmission electron microscopy. Although the surface coverage is comparable for both starting surfaces, film measurements performed by SE suggest that thick films deposited on H-terminated Si are similar to 5 % thicker than similar films on the chemical oxide surface. Atomic force microscopy (AFM) measurements reveal higher surface roughness for the films deposited in the H-terminated surface. The SE and the AFM data are consistent with higher porosity for the films on H-terminated surfaces. (c) 2007 American Institute of Physics. C1 Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Gougousi, T (reprint author), Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA. EM gougousi@Umbc.edu RI Gougousi, Theodosia/C-8156-2014 NR 27 TC 39 Z9 39 U1 1 U2 16 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 2007 VL 102 IS 3 AR 034101 DI 10.1063/1.2764223 PG 7 WC Physics, Applied SC Physics GA 207GW UT WOS:000249240600071 ER PT J AU Xu, W Folkes, PA Gumbs, G AF Xu, W. Folkes, P. A. Gumbs, Godfrey TI Self-consistent electronic subband structure of undoped InAs/GaSb-based type II and broken-gap quantum well systems SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SUPERLATTICES; TRANSITION; GAAS AB Motivated by a very recent experimental work on investigating electronic properties of InAs/GaSb-based type 11 and broken-gap quantum well structures, in this article we present a simple and transparent theoretical approach to calculate electronic subband structure in such device systems. The theoretical model is developed on the basis of solving self-consistently the Schriodinger equation for the eigenfunctions and eigenvalues coupled with the Poisson equation for the confinement potentials, in which the effects such as charge distribution and depletion are considered. In particular, we examine the effect of a GaSb cap layer on electronic properties of the quantum well systems in conjunction with experiments and experimental findings. The results obtained from the proposed self-consistent calculation can be used to understand important experimental findings and are in line with those measured experimentally. (c) 2007 American Institute of Physics. C1 Chinese Acad Sci, Inst Solid State Phys, Hefei 230031, Peoples R China. Australian Natl Univ, Res Sch Phys Sci & Engn, Dept Theoret Phys, Canberra, ACT 0200, Australia. US Army Res Lab, Adelphi, MD 20783 USA. CUNY, CUNY Hunter Coll, Dept Phys, New York, NY 10021 USA. RP Xu, W (reprint author), Chinese Acad Sci, Inst Solid State Phys, Hefei 230031, Peoples R China. EM wen105@rsphysse.anu.edu.au NR 18 TC 15 Z9 15 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 2007 VL 102 IS 3 AR 033703 DI 10.1063/1.2759873 PG 7 WC Physics, Applied SC Physics GA 207GW UT WOS:000249240600041 ER PT J AU Sawka, MN Castellani, JW AF Sawka, Michael N. Castellani, John W. TI How hot is the human body? SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Editorial Material ID THERMOREGULATORY RESPONSES; HEAT; TEMPERATURES; THERMOMETRY; CALORIMETRY; MECHANISMS; STRESS; COLD C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Sawka, MN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. EM michael.sawka@us.army.mil NR 15 TC 11 Z9 11 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG PY 2007 VL 103 IS 2 BP 419 EP 420 DI 10.1152/japplphysiol.00592.2007 PG 2 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 196CP UT WOS:000248459600003 PM 17556501 ER PT J AU Owens, BD Wenke, JC AF Owens, Brett D. Wenke, Joseph C. TI Early wound irrigation improves the ability to remove bacteria SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID OPEN TIBIA FRACTURES; TIME-DELAY; INFECTION; OSTEOMYELITIS; MODEL AB Background: Although most surgeons prefer to treat contaminated wounds as soon as possible, the effect of timing on the ability of irrigation to reduce the amount of bacteria in a wound is not fully known. We evaluated the effect of different delays in irrigation on bacterial removal in an animal model. Methods: A complex musculoskeletal wound was created in the proximal part of the leg of goats. The wound was contaminated with Pseudomonas aeruginosa (lux) bacteria, genetically modified to emit photons, in order to allow for quantitative analysis of bacterial concentration with a photon-counting camera system. The contaminated wounds were closed, and wound irrigation was performed with 6 L of normal saline solution by means of pulsatile lavage after the assigned time-intervals of three, six, and twelve hours. Images were made before and after treatment. Relative luminescent units and clearance ratios were obtained and calculated for each wound. Results: Earlier wound irrigation resulted in superior bacterial removal in our model. Irrigation resulted in a 70% +/- 2%, 52% +/- 3%, and 37% +/- 4% reduction in bacterial counts from the pre-irrigation level at three, six, and twelve hours, respectively. The clearance ratios were significantly different at all time-points (p < 0.004). Conclusions: Earlier irrigation in our contaminated wound model resulted in superior bacterial removal. Clinical Relevance: While the actual bacterial counts necessary to establish a wound infection in humans is unknown, early irrigation of the contaminated wound is recommended for the prevention of infection. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Owens, BD (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Rd, Ft Sam Houston, TX 78234 USA. EM b.owens@us.army.mil; joseph.wenke@us.army.mil NR 17 TC 35 Z9 37 U1 0 U2 2 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD AUG PY 2007 VL 89A IS 8 BP 1723 EP 1726 DI 10.2106/JBJS.F.01210 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 197HX UT WOS:000248546300008 PM 17671010 ER EF