FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Mudupu, V Trabia, MB Yim, W Weinacht, P AF Mudupu, V. Trabia, M. B. Yim, W. Weinacht, P. TI Design and validation of a fuzzy logic controller for a smart projectile fin with a piezoelectric macro-fiber composite bimorph actuator SO SMART MATERIALS & STRUCTURES LA English DT Article ID FLEXIBLE BEAM ACTUATOR; ADAPTIVE-CONTROL; VIBRATION CONTROL; ELEMENTS; SYSTEMS; PLATE AB This paper focuses on the design and validation of a fuzzy logic controller for the smart fin of a projectile. The hollow fin is actuated by a cantilevered piezoelectric bimorph that is completely enclosed within it. A linear model of the actuator and fin is identified experimentally by exciting the system using a chirp signal. A procedure for designing a genetic algorithm (GA)-based fuzzy logic controller for the fin is presented. The controller is validated using simulation and experimental testing that is conducted in the subsonic wind tunnel at the University of Nevada, Las Vegas (UNLV). Results show that the proposed controller accomplishes the desired fin angle control under various operating conditions. C1 [Mudupu, V.; Trabia, M. B.; Yim, W.] Univ Nevada, Las Vegas, NV 89154 USA. [Weinacht, P.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Mudupu, V (reprint author), Univ Nevada, Las Vegas, NV 89154 USA. EM mudupuv@unlv.nevada.edu; mbt@me.unlv.edu OI Trabia, Mohamed/0000-0003-3090-9672 NR 41 TC 3 Z9 3 U1 0 U2 11 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 J9 SMART MATER STRUCT JI Smart Mater. Struct. PD JUN PY 2008 VL 17 IS 3 AR 035034 DI 10.1088/0964-1726/17/3/035034 PG 12 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA 310QE UT WOS:000256544300035 ER PT J AU Palazzo, AJ Clapp, CE Senesi, N Hayes, MHB Cary, TJ Mao, JD Bashore, TL AF Palazzo, Antonio J. Clapp, C. Edward Senesi, Nicola Hayes, Mickael H. B. Cary, Timotky J. Mao, Jing-Dong Bashore, Terry L. TI Isolation and characterization of humic acids in idaho slickspot soils SO SOIL SCIENCE LA English DT Article DE humic acids; slickspot peppergrass; Fourier transform infrared; fluorescence; total luminescence; nuclear magnetic resonance ID ORGANIC-MATTER; LAND-USE; ENGLAND AB Naturally occurring humic substances in soils hold promise as a factor related to restoring native plants. We have characterized the humic acids (HA) from inside and outside slickspots of two sites in the juniper Butte Range soils on the Snake River Plain in Southwest Idaho. These HA may promote the establishment of native slickspot peppergrass (Lepidium papilliferum) seedlings. The HA were extracted from the silt, vesicular, and clay layers using a modified International Humic Substances Society method, and isolated by membrane filtration, precipitation, dialysis, and freeze-drying. Elemental analyses showed minor differences between HA; the inside surface silt samples had higher C and N values than the outside or the deeper samples. Differences were also noted between sample sites and between the samples for carbohydrates, amino acids, and acidity functionalities. Fourier transform infrared and fluorescence, and especially cross-polarization magic angle spinning C-13-nuclear magnetic resonance spectroscopies, provided compositional information and highlighted differences between the samples. C1 [Palazzo, Antonio J.; Cary, Timotky J.] USACOE, Cold Regions Res & Engn Lab, Hanover, NH 03755 USA. [Clapp, C. Edward] Univ Minnesota, USDA ARS, Dept Soil Water & Climate, St Paul, MN 55108 USA. [Senesi, Nicola] Univ Bari, Dip Biol & Chim Agroforestale & Ambientale, I-70121 Bari, Italy. [Hayes, Mickael H. B.] Univ Limerick, Dept Chem & Environm Sci, Limerick, Ireland. [Mao, Jing-Dong] Old Dominion Univ, Norfolk, VA USA. [Bashore, Terry L.] HO Air Combat Command, Airspace Ranges & Air Field Operat Div, Langley AFB, VA USA. RP Palazzo, AJ (reprint author), USACOE, Cold Regions Res & Engn Lab, Hanover, NH 03755 USA. EM Antonio.J.Palazzo@erdc.usace.army.mil RI Hayes, Michael/C-3463-2011 NR 38 TC 4 Z9 4 U1 1 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-075X J9 SOIL SCI JI Soil Sci. PD JUN PY 2008 VL 173 IS 6 BP 375 EP 386 DI 10.1097/SS.01b013e318178e6c5 PG 12 WC Soil Science SC Agriculture GA 315RM UT WOS:000256897100003 ER PT J AU Wu, J Hu, J Zhao, JH Wang, X Li, X Fursin, L Burke, T AF Wu, J. Hu, J. Zhao, J. H. Wang, X. Li, X. Fursin, L. Burke, T. TI Normally-off 4H-SiC trench-gate MOSFETs with high mobility SO SOLID-STATE ELECTRONICS LA English DT Article DE 4H-SiC; trench-gate MOSFETs; mobility ID TECHNOLOGY; INTERFACE AB A new 4H-SiC trench-gate MOSFET structure with epitaxial buried channel for accumulation-mode operation, has been designed and fabricated, aiming at improving channel electron mobility. Coupled with improved fabrication processes, the MOSFET structure eliminates the need of high dose N+ source implantation. High dose N+ implantation requires high-temperature (>= 1550 degrees C) activation annealing and tends to cause substantial surface roughness, which degrades MOSFET threshold voltage stability and gate oxide reliability. The buried channel is implemented without epitaxial regrowth or accumulation channel implantation. Fabricated MOSFETs subject to ohmic contact rapid thermal annealing at 850 degrees C for 5 min exhibit a high peak field-effect mobility (mu(FE)) of 95 cm(2)/V s at room temperature (25 degrees C) and 255 cm(2)/V s at 200 degrees C with stable normally-off operation from 25 degrees C to 200 degrees C. The dependence of channel mobility and threshold voltage on the buried channel depth is investigated and the optimum range of channel depth is reported. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Wu, J.; Hu, J.; Zhao, J. H.] Rutgers State Univ, SiCLAB, Dept Elect & Comp Engn, Piscataway, NJ 08901 USA. [Wang, X.; Li, X.; Fursin, L.] United Silicon Carbide Inc, New Brunswick, NJ 08901 USA. [Burke, T.] US Army TACOM, Warren, MI 48397 USA. RP Wu, J (reprint author), Rutgers State Univ, SiCLAB, Dept Elect & Comp Engn, 94 Breit Rd, Piscataway, NJ 08901 USA. EM jianwu@rci.rutgers.edu NR 14 TC 2 Z9 3 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 EI 1879-2405 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD JUN PY 2008 VL 52 IS 6 BP 909 EP 913 DI 10.1016/j.sse.2008.01.019 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 314YT UT WOS:000256845800012 ER PT J AU Stojadinovic, A Henry, LR Howard, RS Gurevich-Uvena, J Makashay, MJ Coppit, GL Shriver, CD Solomon, NP AF Stojadinovic, Alexander Henry, Leonard R. Howard, Robin S. Gurevich-Uvena, Joyce Makashay, Mattliew J. Coppit, George L. Shriver, Craig D. Solomon, Nancy P. TI Prospective trial of voice outcomes after thyroidectomy: Evaluation of patient-reported and clinician-determined voice assessments in identifying postthyroidectomy dysphonia SO SURGERY LA English DT Article ID VOCAL FOLD PARALYSIS; QUALITY-OF-LIFE; SUPERIOR LARYNGEAL NERVE; EXTERNAL BRANCH; SELF-ASSESSMENT; HANDICAP INDEX; V-RQOL; SURGERY; INJECTION; THERAPY AB Background. Reliable voice grading systems to identify postoperative voice dysfunction by surgeons are needed. Purpose. To examine the utility of Patient-reported and clinician-determined voice assessment in identifying postthyroidectomy voice dysfunction. Patients and Methods. Fifty patients enrolled in a prospective observational trial evaluating voice function perioperatively by patient-reported symptoms (Voice Case History [VCHx]) and perceived voice handicap (Voice Handicap Index [VHI]), clinician-determined judgment of voice quality (Consensus Auditory-Perceptual Evaluation-Voice [CAPE-VI), and laryngeal examination via video laryngoscopy (VLS). Voice dysfunction at first Postoperative visit in symptomatic patients was defined by objective laryngeal abnormalities on VLS. Postoperative changes from baseline in voice parameters were compared between patients with and without voice dysfunction using the Wilcoxon rank sum test. Receiver operating characteristics were evaluated to determine area under the curve (AUC) for tested parameters. Results. Eight (16%) had early transient and 1 (2%) had permanent postoperative voice dysfunction. VCHx symptoms had negative (ATV) and positive (PPV) predictive values of 96%-100% and 39%-53%, respectively for voice dysfunction. The rating of overall severity from the CAPE-V was highly predictive (AUC = 0.96), and a change in severity from preoperative baseline >= 20% at 1-2 weeks had a PPV of 86% and ATV of 95% for postoperative dysphonia. Patient-reported total VHI score was most predictive (AUC = 0.97) and a change in VHI from preoperative baseline >= 25 early postoperatively had a PPV of 88% and NPV of 97% for postoperative dysphonia. Conclusion. Patient self-assessment of voice handicap using the VHI reliably identifies voice dysfunction after thyroidectomy. Patients with a change in VHI >= 25 from preoperative baseline warrant early referral to speech pathology and laryngology. C1 [Stojadinovic, Alexander; Shriver, Craig D.] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Stojadinovic, Alexander; Shriver, Craig D.] US Mil Canc Inst, Washington, DC USA. [Henry, Leonard R.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Div Biostat, Washington, DC 20307 USA. [Gurevich-Uvena, Joyce; Makashay, Mattliew J.; Solomon, Nancy P.] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Dept Surg, Washington, DC 20307 USA. [Coppit, George L.] Walter Reed Army Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, 6900 Georgia Ave,Room 5C27A, Washington, DC 20307 USA. EM alexander.stojadinovic@na.amedd.army.mil NR 44 TC 30 Z9 31 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-6060 J9 SURGERY JI Surgery PD JUN PY 2008 VL 143 IS 6 BP 732 EP 742 DI 10.1016/j.surg.2007.12.004 PG 11 WC Surgery SC Surgery GA 315DU UT WOS:000256858900005 PM 18549889 ER PT J AU Garcia, GE Shi, XR Nambiar, MP Gordon, RK AF Garcia, Gregory E. Shi, Xuerong Nambiar, Madhusoodana P. Gordon, Richard K. TI Reductive therapeutic strategy to prevent BONT intoxication SO TOXICON LA English DT Meeting Abstract CT 6th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins CY JUN 12-15, 2008 CL Baveno, ITALY DE TCEP; prophylaxis; cell culture C1 [Garcia, Gregory E.; Shi, Xuerong; Nambiar, Madhusoodana P.; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 1 PY 2008 VL 51 SU 1 MA 32 BP 11 EP 11 DI 10.1016/j.toxicon.2008.04.034 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 319VJ UT WOS:000257192200033 ER PT J AU Lebeda, F Adler, M Erickson, K Chushak, Y AF Lebeda, Frank Adler, Michael Erickson, Keith Chushak, Yaroslav TI Kinetics of the onset of paralysis produced by type A botulinum neurotoxin SO TOXICON LA English DT Meeting Abstract CT 6th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins CY JUN 12-15, 2008 CL Baveno, ITALY DE therapeutic window; pharmacokinetics; clinical data; in vitro data; in vivo data C1 [Lebeda, Frank] USAMRIID, Frederick, MD USA. [Adler, Michael] USAMRICD, Aberdeen Proving Ground, MD USA. [Erickson, Keith] US Mil Acad, West Point, NY 10996 USA. [Chushak, Yaroslav] BHSAI, AFRL, Wright Patterson AFB, OH USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 1 PY 2008 VL 51 SU 1 MA 44 BP 15 EP 15 DI 10.1016/j.toxicon.2008.04.046 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 319VJ UT WOS:000257192200045 ER PT J AU Nambiar, M Davis, J Pang, YP Shi, XR Gordon, R Millard, C AF Nambiar, Madhusoodana Davis, Jon Pang, Yuan-Ping Shi, Xuerong Gordon, Richard Millard, Charles TI Development of a Botulinum Neurotoxin animal inhalation model and evaluation of small molecule therapeutics for medical countermeasure SO TOXICON LA English DT Meeting Abstract CT 6th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins CY JUN 12-15, 2008 CL Baveno, ITALY DE inhalation exposure; microinstillation; lung injury; small molecule inhibitors; respiratory function C1 [Nambiar, Madhusoodana; Davis, Jon; Shi, Xuerong; Gordon, Richard] Walter Reed Army Inst Res, Silver Spring, MD USA. [Pang, Yuan-Ping; Millard, Charles] Mayo Clin, Rochester, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 1 PY 2008 VL 51 SU 1 MA 47 BP 16 EP 16 DI 10.1016/j.toxicon.2008.04.049 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 319VJ UT WOS:000257192200048 ER PT J AU Shi, XR Garcia, GE Nambiar, MP Gordon, RK AF Shi, Xuerong Garcia, Gregory E. Nambiar, Madhusoodana P. Gordon, Richard K. TI Biological effects of un-nicked BoNT/B toxin SO TOXICON LA English DT Meeting Abstract CT 6th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins CY JUN 12-15, 2008 CL Baveno, ITALY DE un-nicked botulinum toxin; BoNT; bacterial toxin C1 [Shi, Xuerong; Garcia, Gregory E.; Nambiar, Madhusoodana P.; Gordon, Richard K.] Walter Reed Army Inst Res, Div Biochem, Dept Biochem Pharmacol, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 1 PY 2008 VL 51 SU 1 MA 60 BP 20 EP 21 DI 10.1016/j.toxicon.2008.04.062 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 319VJ UT WOS:000257192200061 ER PT J AU Marks, J Garcia, C Geren, IN Lou, JL Forsyth, CM Fraser, C Wen, WH Smith, TJ Brown, J Al-Saleem, F Ancharski, D Simpson, LL Tepp, WH Johnson, EA Smith, LA AF Marks, James Garcia, Consuelo Geren, Isin N. Lou, Jianlong Forsyth, Charles M. Fraser, Conrad Wen, Weihua Smith, Theresa J. Brown, Jennifer Al-Saleem, Fetweh Ancharski, Denise Simpson, Lance L. Tepp, William H. Johnson, Eric A. Smith, Leonard A. TI Recombinant antibody potently neutralizes types A, B, and E botulinum neurotoxins by a clearancedriven mechanism SO TOXICON LA English DT Meeting Abstract CT 6th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins CY JUN 12-15, 2008 CL Baveno, ITALY DE botulism; antitoxin; monoclonal antibody C1 [Garcia, Consuelo; Geren, Isin N.; Lou, Jianlong; Forsyth, Charles M.; Fraser, Conrad; Wen, Weihua] Univ Calif San Francisco, Dept Anesthesia & Pharmaceut Chem, San Francisco, CA 94143 USA. [Smith, Theresa J.; Brown, Jennifer; Smith, Leonard A.] USA, Med Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD USA. [Al-Saleem, Fetweh; Ancharski, Denise; Simpson, Lance L.] Thomas Jefferson Univ, Jefferson Med Coll, Dept Med, Philadelphia, PA 19107 USA. [Tepp, William H.; Johnson, Eric A.] Univ Wisconsin, Dept Food Microbiol & Toxicol, Madison, WI 53706 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUN 1 PY 2008 VL 51 SU 1 MA 150 BP 50 EP 50 DI 10.1016/j.toxicon.2008.04.152 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 319VJ UT WOS:000257192200151 ER PT J AU Hess, JR Holcomb, JB AF Hess, J. R. Holcomb, J. B. TI Transfusion practice in military trauma SO TRANSFUSION MEDICINE LA English DT Review DE battlefield blood support; expedient transfusion; military medicine; war surgery ID DAMAGE CONTROL RESUSCITATION; MASSIVE TRANSFUSION; DILUTIONAL COAGULOPATHY; COMBAT CASUALTIES; BLOOD-PRODUCTS; UNITED-STATES; RED-CELLS; HYPOTHERMIA; FIBRINOGEN; MORTALITY AB Modern warfare causes severe injuries, and despite rapid transportation to theater regional trauma centers, casualties frequently arrive coagulopathic and in shock. Conventional resuscitation beginning with crystalloid fluids to treat shock causes further dilutional coagulopathy and increased hemorrhagic loss of platelets and coagulation factors. Established coagulopathy was difficult to reverse in the face of uncontrolled hemorrhage. Because many of the casualties met conventional plasma and platelet transfusion criteria on admission, thawed AB plasma was prepositioned in the trauma receiving area and used in a 1:1 ratio with red cells for resuscitation and fresh whole blood was used as a source of platelets. Retrospective assessments of this 1:1 therapy strongly suggested that it resulted in improved hemostasis, shorter ventilator times, and improved survival. Component therapy, when available, appears to be as effective as fresh whole blood. In field emergencies, fresh whole blood can be lifesaving. C1 [Hess, J. R.] Univ Maryland, Med Ctr, Blood Bank, Dept Pathol, Baltimore, MD 21201 USA. [Holcomb, J. B.] USA, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA. RP Hess, JR (reprint author), Univ Maryland, Med Ctr, Blood Bank, Dept Pathol, N2W50a,22 S Greene St, Baltimore, MD 21201 USA. EM jhess@umm.edu RI Hess, John/K-4001-2013 OI Hess, John/0000-0001-8596-4420 NR 41 TC 43 Z9 43 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0958-7578 J9 TRANSFUSION MED JI Transfus. Med. PD JUN PY 2008 VL 18 IS 3 BP 143 EP 150 DI 10.1111/j.1365-3148.2008.00855.x PG 8 WC Hematology SC Hematology GA 315EA UT WOS:000256859500001 PM 18598276 ER PT J AU Krishnani, KK Meng, XG Christodoulatos, C Boddu, VM AF Krishnani, Kishore K. Meng, Xiaoguang Christodoulatos, C. Boddu, Veera M. TI Biosorption mechanism of nine different heavy metals onto biomatrix from rice husk SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Biomatrix; heavy metals; removal mechanism ID SUGAR-BEET PULP; BAGASSE FLY-ASH; WASTE-WATER; HEXAVALENT CHROMIUM; AQUEOUS-SOLUTIONS; WHEAT BRAN; COMPETITIVE ADSORPTION; NATURAL POLYSACCHARIDE; ACTIVATED CARBON; INDUSTRY WASTE AB A biomatrix was prepared from rice husk, a lignocellulosic waste from agro-industry, for the removal of several heavy metals as a function of pH and metal concentrations in single and mixed solutions. The biomatrix was characterized using scanning electron microscope and Fourier transform infrared spectroscopy, which indicated the presence of several functional groups for binding metal ions. Different experimental approaches were applied to show mechanistic aspects, especially the role of calcium and magnesium present in the biomatrix in ion exchange mechanism. The ultimate maximum adsorption capacity obtained from the Langmuir isotherm increases in the order (mmol/g): Ni (0.094), Zn (0.124), Cd (0.149), Mn (0.151), Co (0.162), Cu (0.172), Hg (0.18) and Pb (0.28). The sorption of Cr(III) onto biomatrix at pH 2 was 1.0 mmol/g. Speciation of chromium, cadmium and mercury loaded on the biomatrix was determined by X-ray photoelectron spectroscopy. The biomatrix has adsorption capacity comparable or greater to other reported sorbents. (C) 2007 Elsevier B.V. All rights reserved. C1 [Krishnani, Kishore K.] Cent Inst Brackishwater Aquaculture, Madras 600028, Tamil Nadu, India. [Meng, Xiaoguang; Christodoulatos, C.] Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. [Boddu, Veera M.] USA, Construct Engn Res Labs, Champaign, IL 61826 USA. RP Krishnani, KK (reprint author), Cent Inst Brackishwater Aquaculture, Madras 600028, Tamil Nadu, India. EM scientistk@hotmail.com RI Krishnani, K/B-2553-2012 OI Krishnani, K/0000-0003-2774-7772 NR 54 TC 226 Z9 250 U1 19 U2 107 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD MAY 30 PY 2008 VL 153 IS 3 BP 1222 EP 1234 DI 10.1016/j.jhazmat.2007.09.113 PG 13 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 296LG UT WOS:000255544300042 PM 18006228 ER PT J AU Reddy, GS Subbaiah, MV Boddu, VM Krishnaiah, A AF Reddy, G. Sankara Subbaiah, M. Venkata Boddu, Veera M. Krishnaiah, A. TI Thermo physical properties of binary mixtures of n-butylamine with alkyl acetates at 303.15 K SO JOURNAL OF MOLECULAR LIQUIDS LA English DT Article DE excess volumes; compressibility; viscosities; n-butylamine; alkyl acetates ID EXCESS MOLAR VOLUMES; LIQUID-MIXTURES; ALIPHATIC-AMINES; VISCOSITIES; SOUND; DENSITIES; SPEEDS; HYDROCARBONS; HEXANE; THERMODYNAMICS AB Excess volumes, speeds of sound and viscosities were measured for binary mixtures of n-butylamine (NBA) with methyl acetate (MA), ethyl acetate (EA), butyl acetate (BA) and isoamyl acetate (IAA) at 303.15 K over the entire range of composition. Isentropic compressibilities were computed from speed of sound and density data, Densities were obtained from experimental excess volume data in case mixtures. Speeds of sound were evaluated using Jacobson free length theory (FIT) and Schaaffs collision factor theory (CFT). The viscosity data were analyzed on the basis of corresponding states approach and Grunberg and Nissan treatment. The experimental results on excess volume, deviation in isentropic compressibility and in viscosity were discussed in terms of molecular interactions between unlike molecules. A Redlich-Kister type equation was used to fit the experimental data on excess volume, deviations in compressibility and viscosity. (C) 2008 Elsevier B.V. All rights reserved. C1 [Reddy, G. Sankara; Subbaiah, M. Venkata; Krishnaiah, A.] Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermo Phys Lab, Tirupati 517502, Andhra Pradesh, India. [Boddu, Veera M.] USA, Construct Engn Res Lab, Engn Res & Dev Ctr, Champaign, IL 61826 USA. RP Krishnaiah, A (reprint author), Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermo Phys Lab, Tirupati 517502, Andhra Pradesh, India. EM abburikrishnaiah@gmail.com RI Dr. Munagapati, Venkata Subbaiah/D-6761-2011 NR 31 TC 2 Z9 2 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7322 J9 J MOL LIQ JI J. Mol. Liq. PD MAY 30 PY 2008 VL 141 IS 1-2 BP 94 EP 98 DI 10.1016/j.molliq.2008.04.002 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 326AN UT WOS:000257630400014 ER PT J AU Peters-Lidard, CD Mocko, DM Garcia, M Santanello, JA Tischler, MA Moran, MS Wu, YH AF Peters-Lidard, Christa D. Mocko, David M. Garcia, Matthew Santanello, Joseph A., Jr. Tischler, Michael A. Moran, M. Susan Wu, Yihua TI Role of precipitation uncertainty in the estimation of hydrologic soil properties using remotely sensed soil moisture in a semiarid environment SO WATER RESOURCES RESEARCH LA English DT Article ID LAND-SURFACE MODEL; BOUNDARY-LAYER; PEDOTRANSFER FUNCTIONS; HYDRAULIC-PROPERTIES; DATA ASSIMILATION; MONSOON 90; ETA-MODEL; WATER; SIMULATION; PARAMETERIZATION AB The focus of this study is on the role of precipitation uncertainty in the estimation of soil texture and soil hydraulic properties for application to land-atmosphere modeling systems. This work extends a recent study by Santanello et al. (2007) in which it was shown that soil texture and related physical parameters may be estimated using a combination of multitemporal microwave remote sensing, land surface modeling, and parameter estimation methods. As in the previous study, the NASA-GSFC Land Information System modeling framework, including the community Noah land surface model constrained with pedotransfer functions (PTF) for use with the Parameter Estimation Tool, is applied to several sites in the Walnut Gulch Experimental Watershed (WGEW) in southeastern Arizona during the Monsoon '90 experiment period. It is demonstrated that the application of PTF constraints in the estimation process for hydraulic parameters provides accuracy similar to direct hydrologic parameter estimation, with the additional benefit of simultaneously estimated soil texture. Precipitation uncertainty is then represented with systematically varying sources, from the high-density precipitation gauge network in WGEW to lower quality sources, including spatially averaged precipitation, single gauges in and near the watershed, and results from the continental-scale North American Regional Reanalysis data set. It is demonstrated that the quality of the input precipitation data set, and particularly the accuracy of the data set, in both detection of convective ( heavy) rainfall events and reproduction of the observed rainfall rate probabilities, is a critical determinant in the use of successive remote sensing results in order to establish and refine estimates of soil texture and hydraulic properties. C1 [Peters-Lidard, Christa D.; Mocko, David M.; Garcia, Matthew; Santanello, Joseph A., Jr.; Wu, Yihua] NASA, Goddard Space Flight Ctr, Hydrol Sci Branch, Greenbelt, MD 20771 USA. [Mocko, David M.] NASA, Goddard Space Flight Ctr, Climate & Radiat Branch, Greenbelt, MD 20771 USA. [Mocko, David M.] Sci Applicat Int Corp, Beltsville, MD USA. [Garcia, Matthew; Wu, Yihua] Univ Maryland Baltimore Cty, Goddard Earth Sci & Technol Ctr, Baltimore, MD 21228 USA. [Santanello, Joseph A., Jr.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. [Tischler, Michael A.] USA, Corps Engineers, Ctr Res Dev & Engn, Topograph Engn Ctr, Alexandria, VA 22315 USA. [Moran, M. Susan] USDA ARS, SW Watershed Res Ctr, Tucson, AZ 85719 USA. RP Wu, YH (reprint author), NASA, Goddard Space Flight Ctr, Hydrol Sci Branch, Code 6143, Greenbelt, MD 20771 USA. EM christa.peters@nasa.gov; david.mocko@nasa.gov; matthew.garcia@nasa.gov; joseph.santanello@nasa.gov; michael.a.tischler@erdc.usace.army.mil; smoran@tucson.ars.ag.gov; yihua.wu@noaa.gov RI Santanello, Joseph/D-4438-2012; Garcia, Matthew/K-9286-2013; Peters-Lidard, Christa/E-1429-2012 OI Santanello, Joseph/0000-0002-0807-6590; Garcia, Matthew/0000-0002-9637-4204; Peters-Lidard, Christa/0000-0003-1255-2876 NR 63 TC 19 Z9 21 U1 1 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD MAY 30 PY 2008 VL 44 IS 5 AR W05S18 DI 10.1029/2007WR005884 PG 22 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 308BS UT WOS:000256363900001 ER PT J AU Li, H Piekarski, B Devoe, DL Balachandran, B AF Li, H. Piekarski, B. DeVoe, D. L. Balachandran, B. TI Nonlinear oscillations of piezoelectric microresonators with curved cross-sections SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article DE clamped-clamped resonator structure; piezoelectric actuation; MEMS resonator; stepwise varying properties; buckling; curved cross-section ID MICROMACHINED BEAMS; RESONATORS AB Nonlinear oscillations of microelectromechanical resonators with curved cross-sections are studied in this effort. The resonators are fabricated as clamped-clamped composite structures, and these structures have both lengthwise and widthwise curvatures induced by residual stresses. Harmonic piezoelectric actuations of these structures were considered in experiments and the spatial responses of these structures were studied. The spatial responses observed for different resonance excitations could not be explained by a previous model of these composite microresonators, where stepwise non-uniform properties along the length and rectangular cross-sections were considered. Here, a curved cross-section model is adopted to refine the previous model and the resulting predictions are found to compare better with the experimental observations. The results show that the cross-section curvature significantly affects the structural stiffness and response, and this is important to consider in system modeling. Published by Elsevier B.V. C1 [Li, H.; DeVoe, D. L.; Balachandran, B.] Univ Maryland, Dept Mech Engn, Adelphi, MD 20783 USA. [Piekarski, B.] USA, Res Lab, Adelphi, MD 20783 USA. RP Balachandran, B (reprint author), Univ Maryland, Dept Mech Engn, Glenn L Martin Hall,Coll Pk, Adelphi, MD 20783 USA. EM balab@umd.edu RI DeVoe, Don/A-2891-2011 OI DeVoe, Don/0000-0002-7740-9993 NR 18 TC 17 Z9 17 U1 0 U2 6 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD MAY 28 PY 2008 VL 144 IS 1 BP 194 EP 200 DI 10.1016/j.sna.2007.12.015 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 302TU UT WOS:000255993200026 ER PT J AU Saito, T Mather, BD Costanzo, PJ Beyer, FL Long, TE AF Saito, Tomonori Mather, Brian D. Costanzo, Philip J. Beyer, Frederick L. Long, Timothy E. TI Influence of site-specific sulfonation on acrylic graft copolymer morphology SO MACROMOLECULES LA English DT Article ID X-RAY-SCATTERING; HYDROPHOBICALLY-MODIFIED POLYELECTROLYTES; AMPHIPHILIC DIBLOCK COPOLYMERS; TETRAFUNCTIONAL BRANCH-POINTS; PROTON-EXCHANGE MEMBRANES; BLOCK-COPOLYMERS; TRANSPORT-PROPERTIES; POLYSTYRENE; IONOMERS; POLYMERS AB Novel selectively sulfonated graft copolymers, poly(methyl methacrylate)-g-(poly(sulfonic acid styrene)-b-poly(tert-butyl styrene)), poly(methyl methacryl ate)-g-(poly(tert-butylstyrene)-b-poly(styrenesulfonic acid)), and the corresponding sodium sulfonate salts were successfully synthesized. The weight-average molecular weights (M,) of the graft copolymers were similar to 200 000 g/mol and the polydispersity ranged from 1.86 to 2.22. The graft copolymers contained similar to 9-10 branches on average and 4 wt % of sulfonic acid or sodium sulfonate blocks adjacent to the backbone or at the branch terminus. The mobility of the sulfonated blocks located at the branch terminus enabled the sulfonated blocks to more readily interact and form ionic aggregates. The glass transition temperatures of the sulfonated graft copolymer with sulfonated blocks at the branch terminus were higher than values for copolymers with sulfonated blocks adjacent to the backbone. This behavior was attributed to the sulfonated blocks at the branch terminus more easily forming ionic aggregates. In general, appearance of multiple scattering maxima in the small-angle X-ray scattering (SAXS) data indicated the formation of lamellar morphologies. More facile aggregation of sulfonated blocks at the branch terminus resulted in the appearance of ionomer peaks in SAXS whereas ionomer peaks were not observed in sulfonated graft copolymers with sulfortated blocks adjacent to the backbone. Reasonable fits of the Yarusso-Cooper model to the SAXS data strongly supported the identification of the nonlamellar maxima as ionomer peaks. Strong ionic interactions with Na+ counterions reduced the Bragg spacings, d, of the sodium sulfonate graft copolymers and increased the size of the ionic aggregates. The location of sulfonated blocks in both sulfonic acid and sodium sulfonate graft copolymers significantly affected thermal properties and morphologies. C1 [Saito, Tomonori; Mather, Brian D.; Long, Timothy E.] Virginia Tech, Macromol & Interfaces Inst, Dept Chem, Blacksburg, VA 24061 USA. [Beyer, Frederick L.] USA, Ballist Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. [Costanzo, Philip J.] Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA. RP Long, TE (reprint author), Virginia Tech, Macromol & Interfaces Inst, Dept Chem, Blacksburg, VA 24061 USA. EM telong@vt.edu RI Costanzo, Philip/E-8879-2011; Saito, Tomonori/M-1735-2016 OI Costanzo, Philip/0000-0001-6220-463X; Saito, Tomonori/0000-0002-4536-7530 NR 40 TC 13 Z9 13 U1 0 U2 18 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD MAY 27 PY 2008 VL 41 IS 10 BP 3503 EP 3512 DI 10.1021/ma800178d PG 10 WC Polymer Science SC Polymer Science GA 303RK UT WOS:000256058000019 ER PT J AU Podpirka, A Cole, MW Ramanathan, S AF Podpirka, Adrian Cole, M. W. Ramanathan, Shriram TI Effect of photon irradiation on structural, dielectric, and insulating properties of Ba(0.60)Sr(0.40)TiO(3) thin films SO APPLIED PHYSICS LETTERS LA English DT Article ID PULSED-LASER DEPOSITION; LEAKAGE CURRENTS; OPTIMIZATION; CAPACITORS; STRESS AB The effect of ultraviolet (UV) photon assisted annealing on the structural, dielectric, and insulating properties of barium strontium titanate (BST) thin films was investigated. Isothermal-temporal annealing experiments revealed that the films annealed utilizing UV assist possessed enhanced crystallization and lattice parameters closer to bulk values with respect to conventional thermal annealed films. The leakage current density and dielectric loss of the films was significantly reduced by employing UV-assisted annealing without degradation of film tunability. Mitigation of oxygen vacancies, associated with the UV-assisted annealing, is deemed responsible for the improvement of the dielectric and electrical properties of the BST thin films. (c) 2008 American Institute of Physics. C1 [Podpirka, Adrian; Ramanathan, Shriram] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. [Cole, M. W.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Ramanathan, S (reprint author), Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. EM mcole@arl.army.mil; shriram@seas.harvard.edu OI Podpirka, Adrian/0000-0002-4000-989X NR 22 TC 27 Z9 28 U1 0 U2 19 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 26 PY 2008 VL 92 IS 21 AR 212906 DI 10.1063/1.2936305 PG 3 WC Physics, Applied SC Physics GA 307FI UT WOS:000256303500055 ER PT J AU Hite, JK Allums, KK Thaler, GT Abernathy, CR Pearton, SJ Frazier, RM Dwivedi, R Wilkins, R Zavada, JM AF Hite, J. K. Allums, K. K. Thaler, G. T. Abernathy, C. R. Pearton, S. J. Frazier, R. M. Dwivedi, R. Wilkins, R. Zavada, J. M. TI Effects of proton irradiation on the magnetic properties of GaGdN and GaCrN SO NEW JOURNAL OF PHYSICS LA English DT Article ID ELECTRON-MOBILITY TRANSISTORS; MOLECULAR-BEAM EPITAXY; LIGHT-EMITTING-DIODES; SPIN-ELECTRONICS; GAN; SEMICONDUCTORS; SPACE AB GaGdN and GaCrN films grown by gas source molecular beam epitaxy were irradiated with high energy (10 and 40 MeV) protons at a fluence of 5 x 109 cm(-2) to examine the effect on magnetization. This dose is equivalent to the exposure expected in 10 years in low-earth orbit space missions. Both photoluminescence intensity and magnetization of the films showed significant decreases with irradiation. The largest response was observed with GaGdN, which experienced a 50-60% loss in band edge luminescence and 11-83% loss in magnetic saturation. After annealing the irradiated samples at 500 degrees C under a nitrogen plasma ambient, both types of films experienced a complete recovery in magnetic properties. The fact that the introduction of point defects did not increase the magnetization is evidence against unpaired bonds from defects in the film being responsible for the magnetic properties in the films. C1 [Hite, J. K.; Allums, K. K.; Thaler, G. T.; Abernathy, C. R.; Pearton, S. J.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Frazier, R. M.] USN, Res Lab, Washington, DC 20375 USA. [Zavada, J. M.] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Dwivedi, R.; Wilkins, R.] Prairie View AM Univ, Ctr Appl Radiat Res, Prairie View, TX 77446 USA. RP Pearton, SJ (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.ufl.edu RI Hite, Jennifer/L-5637-2015 OI Hite, Jennifer/0000-0002-4090-0826 NR 31 TC 3 Z9 3 U1 0 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1367-2630 J9 NEW J PHYS JI New J. Phys. PD MAY 23 PY 2008 VL 10 AR 055005 DI 10.1088/1367-2630/10/5/055005 PG 8 WC Physics, Multidisciplinary SC Physics GA 308YM UT WOS:000256426800001 ER PT J AU Skirvin, S Kidwell, M Biedenbender, S Henley, JP King, D Collins, CH Moran, S Weltz, M AF Skirvin, Susan Kidwell, Mary Biedenbender, Sharon Henley, J. P. King, Donna Collins, Chandra Holifield Moran, Susan Weltz, Mark TI Vegetation data, Walnut Gulch Experimental Watershed, Arizona, United States SO WATER RESOURCES RESEARCH LA English DT Article ID LAND-COVER; RUNOFF AB The U. S. Department of Agriculture Agricultural Research Service Southwest Watershed Research Center Walnut Gulch Experimental Watershed (WGEW) is an outdoor laboratory located in southeastern Arizona to study water and soil conservation in semiarid lands. Permanent vegetation transects were established adjacent to 55 rain gauges within WGEW in 1967 to quantify vegetation. Some sites were subsequently added or dropped. Detailed vegetation data were collected in 1967, 1994-2000, and 2005, including repeat photography of transects. Ground cover data were collected after 1967. A vegetation map was developed in 2002. The transect sites, vegetation map, data collection methods, and current data availability are described. Data are available at http://www.tucson.ars.ag.gov/dap/. C1 [Skirvin, Susan] Univ Arizona, Dept Min & Geol Engn, Tucson, AZ 85721 USA. [Skirvin, Susan] Kriyah Consultants LLC, Tucson, AZ USA. [Kidwell, Mary; Collins, Chandra Holifield; Moran, Susan] USDA ARS, SW Watershed Res Ctr, Tucson, AZ 85719 USA. [Biedenbender, Sharon] US Forest Serv, Coronado Natl Forest, USDA, Hereford, AZ 85615 USA. [Henley, J. P.] USA, Corp Engineers, Topog Engn Ctr, Alexandria, VA 22315 USA. [King, Donna] Univ Arizona, Sch Nat Resources, Tucson, AZ 85721 USA. [Weltz, Mark] USDA ARS, Natl Program Staff, Beltsville, MD USA. [Weltz, Mark] USDA ARS, Exot & Invas Weeds Res Unit, Reno, NV 89512 USA. RP Skirvin, S (reprint author), Univ Arizona, Dept Min & Geol Engn, 1235 E James E Rogers Way,Room 229,POB 210012, Tucson, AZ 85721 USA. EM sskirvin@ag.arizona.edu NR 20 TC 20 Z9 20 U1 0 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD MAY 22 PY 2008 VL 44 IS 5 AR W05S08 DI 10.1029/2006WR005724 PG 6 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 304XZ UT WOS:000256143700001 ER PT J AU Stengel, JZ Arnold, HL AF Stengel, Joel Z. Arnold, Hays L. TI Is infliximab safe to use while breastfeeding? SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE inflammatory bowel disease; ulcerative colitis; Crohn's disease; pregnancy; breast-feeding; monoclonal antibodies ID INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; PREGNANCY; ETANERCEPT; INDUCTION; REMISSION AB Inflammatory bowel disease (IBD) often affects women around the age of conception and pregnancy. Most drugs used to treat IBD are safe in pregnancy, but physicians must consider the clinical implications of certain treatment regimens in young, fertile females. We report an informative case of a pregnant patient with IBD who underwent treatment with infliximab during her pregnancy and while nursing her infant. Serum and breast milk infliximab levels were monitored throughout this time period. This case report suggests that targeted monoclonal antibodies and other biologic agents can be used with caution in pregnant and breastfeeding patients. (C) 2008 WJG. All rights reserved. C1 [Stengel, Joel Z.] Brooke Army Med Ctr, Gastroenterol Serv, Ft Sam Houston, TX 78234 USA. RP Stengel, JZ (reprint author), Brooke Army Med Ctr, Gastroenterol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM joel.stengel@us.army.mil NR 15 TC 56 Z9 59 U1 0 U2 1 PU W J G PRESS PI BEIJING PA APT 1066, YISHOU GARDEN, NO 58, NORTH LANGXINZHUANG RD, PO BOX 2345, BEIJING 100023, PEOPLES R CHINA SN 1007-9327 J9 WORLD J GASTROENTERO JI World J. Gastroenterol. PD MAY 21 PY 2008 VL 14 IS 19 BP 3085 EP 3087 DI 10.3748/wjg.14.3085 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 305IQ UT WOS:000256172100023 PM 18494064 ER PT J AU Cirino, CM Leitman, SF Williams, E Fedorko, D Palmore, TN Klion, A Ockenhouse, C Fitzhugh, C Tisdale, JF Hsieh, MM AF Cirino, Christopher M. Leitman, Susan F. Williams, Esther Fedorko, Daniel Palmore, Tara N. Klion, Amy Ockenhouse, Christian Fitzhugh, Courtney Tisdale, John F. Hsieh, Matthew M. TI Transfusion-associated babesiosis with an atypical time course after nonmyeloablative transplantation for sickle cell disease SO ANNALS OF INTERNAL MEDICINE LA English DT Letter C1 [Cirino, Christopher M.] St Vincent Hlth Ctr, Erie, PA 16544 USA. [Leitman, Susan F.; Williams, Esther; Fedorko, Daniel] NIH, Warren G Magnuson Clin Ctr, Bethesda, MD 20892 USA. [Palmore, Tara N.; Klion, Amy] NIAID, NIH, Bethesda, MD 20892 USA. [Ockenhouse, Christian] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Fitzhugh, Courtney; Tisdale, John F.; Hsieh, Matthew M.] NIDDKD, NIH, Bethesda, MD 20892 USA. RP Cirino, CM (reprint author), St Vincent Hlth Ctr, Erie, PA 16544 USA. OI Klion, Amy/0000-0002-4986-5326 FU Intramural NIH HHS [Z99 CL999999] NR 6 TC 10 Z9 10 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAY 20 PY 2008 VL 148 IS 10 BP 794 EP 795 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 308EX UT WOS:000256372200015 PM 18490697 ER PT J AU Benavides, LC Holmes, JP Gates, JD Carmichael, MG Hueman, MT Mittendorf, EA von Hofe, E Ponniah, S Peoples, GE AF Benavides, L. C. Holmes, J. P. Gates, J. D. Carmichael, M. G. Hueman, M. T. Mittendorf, E. A. von Hofe, E. Ponniah, S. Peoples, G. E. TI Results of the first phase I clinical trial of the novel Ii-key hybrid preventive HER2/neu peptide (AE37) vaccine: United States Military Cancer Institute Clinical Trials Group Study I-03 SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USN, Med Ctr, San Diego, CA 92152 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Canc Vaccine Dev Program, Bethesda, MD USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. Antigen Express Inc, Worcester, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2008 VL 26 IS 15 SU S MA 3016 PG 1 WC Oncology SC Oncology GA V25CZ UT WOS:000208457400770 ER PT J AU Bubalo, JS Takemoto, MH Herrington, J Miller, CF Wong, L Fisher, A Roberson, EM Wilmann, P Williams, C Edwards, MS Blanke, CD AF Bubalo, J. S. Takemoto, M. H. Herrington, J. Miller, C. F. Wong, L. Fisher, A. Roberson, E. M. Wilmann, P. Williams, C. Edwards, M. S. Blanke, C. D. TI A multi-center, open label trial to evaluate the efficacy and tolerability of aprepitant (A) and palonosetron (P) for the prevention of chemotherapy-induced nausea and vomiting in colorectal cancer (CRC) patients receiving FOLFOX chemotherapy SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Oregon Hlth Sci Univ Hosp, Portland, OR USA. Kaiser Permanente, Honolulu, HI USA. Scott & White Mem Hosp & Clin, Temple, TX 76508 USA. Ingalls Mem Hosp, Harvey, IL USA. Candler Hlth Syst, Savannah, GA USA. Kansas City Canc Ctr, Kansas City, MO USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2008 VL 26 IS 15 SU S MA 20684 PG 1 WC Oncology SC Oncology GA V25CZ UT WOS:000208457403304 ER PT J AU Carmichael, MG Peoples, GE Benevides, LC Gates, JD Patil, R Amin, A Jama, YH Craig, D Ponniah, S Holmes, JP AF Carmichael, M. G. Peoples, G. E. Benevides, L. C. Gates, J. D. Patil, R. Amin, A. Jama, Y. H. Craig, D. Ponniah, S. Holmes, J. P. TI Increased incidence of HLA-DR3+individuals amongst HER2/neu expressing breast cancer patients SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Windber Med Ctr, Windber, PA USA. Canc Vaccine Dev Program, Bethesda, MD USA. USN, San Diego Med Ctr, San Diego, CA 92152 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2008 VL 26 IS 15 SU S MA 22215 PG 1 WC Oncology SC Oncology GA V25CZ UT WOS:000208457404085 ER PT J AU Cohen, J Shin, JY Teoh, D Hamilton, CA Kapp, DS Chan, JK AF Cohen, J. Shin, J. Y. Teoh, D. Hamilton, C. A. Kapp, D. S. Chan, J. K. TI Factors associated with publication of plenary presentations at the Annual Meeting of the Society of Gynecologic Oncology SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Univ Calif San Francisco, San Francisco, CA 94143 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Stanford Univ, Stanford, CA 94305 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2008 VL 26 IS 15 SU S MA 17566 PG 1 WC Oncology SC Oncology GA V25CZ UT WOS:000208457402418 ER PT J AU Ellsworth, RE Heckman, C Seebach, J Field, LA Love, B Hooke, JA Shriver, CD AF Ellsworth, R. E. Heckman, C. Seebach, J. Field, L. A. Love, B. Hooke, J. A. Shriver, C. D. TI Identification of a gene expression breast cancer nodal metastasis profile SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Invitrogen, Carlsbad, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2008 VL 26 IS 15 SU S MA 1022 PG 1 WC Oncology SC Oncology GA V25CZ UT WOS:000208457400309 ER PT J AU Farley, JH Tian, C Rose, GS Brown, CL Risinger, JI Maxwell, GL AF Farley, J. H. Tian, C. Rose, G. S. Brown, C. L. Risinger, J. I. Maxwell, G. L. TI Ethnicity and clinical outcome for advanced epithelial ovarian cancer patients treated by standard cisplatin/paclitaxel chemotherapy: A combined analysis of gynecologic oncology group clinical trials SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Gynecol Oncol Grp, Rosewell Pk, NY USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. Curtis & Elizabeth Anderson Canc Inst, Savannah, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2008 VL 26 IS 15 SU S MA 5573 PG 1 WC Oncology SC Oncology GA V25CZ UT WOS:000208457402130 ER PT J AU Gates, JD Benavides, LC Carmichael, MG Holmes, JP Hueman, MT Mittendorf, EA McLeod, DG Ponniah, S Peoples, GE AF Gates, J. D. Benavides, L. C. Carmichael, M. G. Holmes, J. P. Hueman, M. T. Mittendorf, E. A. McLeod, D. G. Ponniah, S. Peoples, G. E. TI Long-term follow-up assessment of a HER-2/neu peptide (E75) vaccine for the prevention of recurrence in high-risk prostate cancer patients SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. USN, San Diego Med Ctr, San Diego, CA 92152 USA. Canc Vaccine Dev Program, Bethesda, MD USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2008 VL 26 IS 15 SU S MA 3067 PG 1 WC Oncology SC Oncology GA V25CZ UT WOS:000208457400743 ER PT J AU Huang, YJ Lundy, PM Lazaris, A Huang, Y Baldassarre, H Wang, B Turcotte, C Cote, M Bellemare, A Bilodeau, AS Brouillard, S Touati, M Herskovits, P Begin, I Neveu, N Brochu, E Pierson, J Hockley, DK Cerasoli, DM Lenz, DE Wilgus, H Karatzas, CN Langermann, S AF Huang, Yue-Jin Lundy, Paul M. Lazaris, Anthoula Huang, Yue Baldassarre, Hernan Wang, Bin Turcotte, Carl Cote, Melanie Bellemare, Annie Bilodeau, Annie S. Brouillard, Sandra Touati, Madjid Herskovits, Peter Begin, Isabelle Neveu, Nathalie Brochu, Eric Pierson, Janice Hockley, Duncan K. Cerasoli, Douglas M. Lenz, David E. Wilgus, Harvey Karatzas, Costas N. Langermann, Solomon TI Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin SO BMC BIOTECHNOLOGY LA English DT Article ID VITRO-MATURED OOCYTES; NERVE AGENT TOXICITY; POLYETHYLENE-GLYCOL; MASS-SPECTROMETRY; NUCLEAR TRANSFER; HALF-LIFE; IN-VITRO; SOMAN; PROTEINS; MONKEYS AB Background: Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD50 of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life. This study was undertaken to produce recombinant huBChE fused to human serum albumin (hSA) and characterize the fusion protein. Results: Secretion level of the fusion protein produced in vitro in BHK cells was similar to 30 mg/liter. Transgenic mice and goats generated with the fusion constructs expressed in their milk a bioactive protein at concentrations of 0.04-1.1 g/liter. BChE activity gel staining and a size exclusion chromatography (SEC)- HPLC revealed that the fusion protein consisted of predominant dimers and some monomers. The protein was confirmed to have expected molecular mass of similar to 150 kDa by Western blot. The purified fusion protein produced in vitro was injected intravenously into juvenile pigs for pharmacokinetic study. Analysis of a series of blood samples using the Ellman assay revealed a substantial enhancement of the plasma half-life of the fusion protein (similar to 32 h) when compared with a transgenically produced huBChE preparation containing > 70% tetramer (similar to 3 h). In vitro nerve agent binding and inhibition experiments indicated that the fusion protein in the milk of transgenic mice had similar inhibition characteristics compared to human plasma BChE against the nerve agents tested. Conclusion: Both the pharmacokinetic study and the in vitro nerve agent binding and inhibition assay suggested that a fusion protein retaining both properties of huBChE and hSA is produced in vitro and in vivo. The production of the fusion protein in the milk of transgenic goats provided further evidence that sufficient quantities of BChE/hSA can be produced to serve as a cost-effective and reliable source of BChE for prophylaxis and post-exposure treatment. C1 [Huang, Yue-Jin; Lazaris, Anthoula; Huang, Yue; Baldassarre, Hernan; Wang, Bin; Turcotte, Carl; Cote, Melanie; Bellemare, Annie; Bilodeau, Annie S.; Brouillard, Sandra; Touati, Madjid; Herskovits, Peter; Begin, Isabelle; Neveu, Nathalie; Brochu, Eric; Pierson, Janice; Hockley, Duncan K.; Wilgus, Harvey; Karatzas, Costas N.; Langermann, Solomon] PharmAthens Canada Inc, Montreal, PQ H4S 2C8, Canada. [Lundy, Paul M.] Def Res & Dev Canada Suffield, Chem Biol Def Sect, Medicine Hat, AB T1B 8K6, Canada. [Cerasoli, Douglas M.; Lenz, David E.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Lazaris, Anthoula] McGill Univ, Quebec Transgen Res Network, Montreal, PQ H3G 1Y6, Canada. [Wang, Bin] NewLife Fertil Ctr, Mississauga, ON L4Z 2G6, Canada. [Karatzas, Costas N.] CNKonsulting & Aegis Biores, Beaconsfield, PQ H9W 2H4, Canada. RP Huang, YJ (reprint author), PharmAthens Canada Inc, 7150 Alexander Fleming, Montreal, PQ H4S 2C8, Canada. EM yjhuang@videotron.ca; pjlundy@shaw.ca; anthoula.lazaris@rrtq.org; yue31@hotmail.com; hbaldassarre@pharmathene.ca; bwang@newlifefertility.com; cturcotte@pharmathene.ca; melanie.cote.4@umontreal.ca; abellemare@pharmathene.ca; pierrem04@aei.ca; sbrouillard@painceptor.com; majidtouati@hotmail.com; PHersko@aol.com; ibegin2002@yahoo.ca; nneveu@pharmathene.ca; ebrochu@pharmathene.ca; jpierson@pharmathene.ca; dhockley@pharmathene.ca; douglas.cerasoli@us.army.mil; david.lenz@us.army.mil; hwilgus@videotron.ca; ckaratzas@videotron.ca; langermanns@amplimmune.com NR 40 TC 32 Z9 32 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6750 J9 BMC BIOTECHNOL JI BMC Biotechnol. PD MAY 16 PY 2008 VL 8 AR 50 DI 10.1186/1472-6750-8-50 PG 11 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 309FS UT WOS:000256446700002 PM 18485214 ER PT J AU Inoue, J Kikuchi, T Perovich, DK AF Inoue, Jun Kikuchi, Takashi Perovich, Donald K. TI Effect of heat transmission through melt ponds and ice on melting during summer in the Arctic Ocean SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID SEA-ICE; RADIATION; MODEL; CLIMATE; BUDGET; SHEBA; LAYER; FLUX AB To observe sea ice and ocean conditions in the Arctic in summer, a trans-Arctic research cruise of the U. S. Coast Guard Cutter Healy was conducted from 5 August to 30 September 2005. The relationship between the ice concentration observed by the on-board ice-watch and the temperature above the freezing point (DT) measured by expendable conductivity-temperature-depth (XCTD) sensors had a negative correlation (CT-relationship) before the onset of freezing. This means that as ice concentration decreases, DT increases due to the larger absorption of solar radiation. However, DT in high ice-covered regions (> 90%) remains more than 0.1 K during the melting season, suggesting that sea-ice and melt-pond areas work as heat source areas as well as leads. By separating the effects of heat input from open water, melt ponds, and ice on the heating of mixed layers, we found that the contribution of the transmitted heat through ponds and ice on the DT-gain is large in highly ice-covered regions. To examine the effect of such heating on ice melting, a simplified ice-ocean-coupled model was applied. By changing the heat input to obtain the analyzed DT-gain for each surface category, the transmittances of ponds and ice were indirectly estimated as 55% and 9%, respectively. After including the effects of transmitted heat through ponds and ice, the modeled results agreed with the observed CT-relationship. Comparisons between the results of turning on and off the effect of transmitted heat through ponds and ice showed that it amplified the open water-albedo feedback mechanism in the highly ice-covered region. C1 [Inoue, Jun; Kikuchi, Takashi] Japan Agcy Marine Earth Sci & Technol, Inst Observat Res Global Change, Yokosuka, Kanagawa 2370061, Japan. [Perovich, Donald K.] Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA. RP Inoue, J (reprint author), Japan Agcy Marine Earth Sci & Technol, Inst Observat Res Global Change, 2-15 Natsushimacho, Yokosuka, Kanagawa 2370061, Japan. EM jun.inoue@jamstec.go.jp NR 34 TC 14 Z9 14 U1 1 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAY 16 PY 2008 VL 113 IS C5 AR C05020 DI 10.1029/2007JC004182 PG 13 WC Oceanography SC Oceanography GA 303SX UT WOS:000256062300001 ER PT J AU Blonsky, JJ Harrison, SA AF Blonsky, J. J. Harrison, S. A. TI Review article: nonalcoholic fatty liver disease and hepatitis C virus - partners in crime SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS LA English DT Review ID SUSTAINED VIROLOGICAL RESPONSE; TRIGLYCERIDE TRANSFER PROTEIN; PEGINTERFERON PLUS RIBAVIRIN; INDEPENDENT RISK-FACTOR; NECROSIS FACTOR-ALPHA; SERUM LEPTIN LEVELS; INSULIN-RESISTANCE; HEPATOCELLULAR-CARCINOMA; CORE PROTEIN; ANTIVIRAL THERAPY AB Background Both nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) are frequent causes of chronic liver disease. In recent years, there have been significant revelations as regards the relationship between NAFLD and CHC. Aim To conduct a systematic, evidence-based review of the epidemiology, pathophysiology and potential treatments of coexistent NAFLD and CHC. Methods The terms such as hepatitis C, fatty liver, NAFLD, nonalcoholic steatohepatitis and steatosis were searched on PubMed up to January 2008. References from selected articles and pertinent abstracts were also included. Results Hepatic steatosis affects up to 80% of patients with CHC and is dependent on both viral and host factors. While insulin resistance (IR) is associated with hepatic steatosis and hepatitis C virus, genotype-specific pathogenic mechanisms have been identified and are currently the focus of intense investigation in the literature. Clinical implications of concurrent NAFLD, CHC and IR include increased disease progression, elevated risk of hepatocellular carcinoma, and decreased response to antiviral therapy. Conclusions NAFLD and IR are common in patients with CHC virus infection. IR is a driving force in the development of hepatic steatosis. Because of the clinical implications of hepatic steatosis and IR in the setting of CHC, further studies evaluating treatments, which may increase response to antiviral therapy, are needed. C1 [Blonsky, J. J.; Harrison, S. A.] Brooke Army Med Ctr, Dept Gastroenterol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil NR 94 TC 16 Z9 16 U1 0 U2 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0269-2813 J9 ALIMENT PHARM THERAP JI Aliment. Pharmacol. Ther. PD MAY 15 PY 2008 VL 27 IS 10 BP 855 EP 865 DI 10.1111/j.1365-2036.2008.03672.x PG 11 WC Gastroenterology & Hepatology; Pharmacology & Pharmacy SC Gastroenterology & Hepatology; Pharmacology & Pharmacy GA 288LV UT WOS:000254988800001 PM 18315584 ER PT J AU Yuan, FP Tsai, L Prakash, V Dandekar, DP Rajendran, AM AF Yuan, Fuping Tsai, Liren Prakash, Vikas Dandekar, Dattatraya P. Rajendran, A. M. TI Dynamic shear strength of S2 glass fiber reinforced polymer composites under shock compression SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INTEGRAL ARMOR; IMPACT; INTERFEROMETER; ALUMINUM AB In the present paper, a series of plate impact shock-reshock and shock-release experiments were conducted to study the critical shear strength of a S2 glass fiber reinforced polymer (GRP) composite under shock compression levels ranging from 0.8 to 1.8 GPa. The GRP was fabricated at ARL, Aberdeen, using S2 glass woven roving in a Cycom 4102 polyester resin matrix. The experiments were conducted by using an 82.5 mm bore single-stage gas gun at Case Western Reserve University. In order to conduct shock-reshock and shock-release experiments a dual flyer plate assembly was utilized. The shock-reshock experiments were conducted by using a projectile faced with GRP and backed with a relatively high shock impedance Al 6061-T6 plate; while for the shock-release experiments the GRP was backed by a relatively lower impedance polymethyl methacrylate backup flyer plate. A multibeam velocity interferometer was used to measure the particle velocity profile at the rear surface of the target plate. By using self-consistent technique procedure described by Asay and Chabbildas [Shock Waves and High-Strain-Rate Phenomena, in Metals, edited by M. M. Myers and L. E. Murr (Plenum, New York, 1981), pp. 417-431], the critical shear strength of the GRP (2 tau(c)) was determined for impact stresses in the range of 0.8 to 1.8 GPa. The results show that the critical shear strength of the GRP is increased from 0.108 GPa to 0.682 GPa when the impact stress is increased from 0.8 to 1.8 GPa. The increase in critical shear strength may be attributed to rate-dependence and/or pressure dependent yield behavior of the GRP. (C) 2008 American Institute of Physics. C1 [Yuan, Fuping; Tsai, Liren; Prakash, Vikas] Case Western Reserve Univ, Dept Mech & Aerosp Engn, Cleveland, OH 44106 USA. [Dandekar, Dattatraya P.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Rajendran, A. M.] USA, Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27709 USA. RP Yuan, FP (reprint author), Case Western Reserve Univ, Dept Mech & Aerosp Engn, Cleveland, OH 44106 USA. EM fxy11@case.edu; 1xt23@case.edu; vikas.prakash@case.edu; ddandek@arl.army.mil; raj@arl.aro.army.mil RI Rajendran, Arunachalam/A-1615-2010 NR 27 TC 4 Z9 5 U1 1 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 15 PY 2008 VL 103 IS 10 AR 103537 DI 10.1063/1.2930995 PG 8 WC Physics, Applied SC Physics GA 307FK UT WOS:000256303800058 ER PT J AU Gu, YC Li, QG Melendez, V Weina, P AF Gu, Yuanchao Li, Qigui Melendez, Victor Weina, Peter TI Comparison of HPLC with electrochemical detection and LC-MS/MS for the separation and validation of artesunate and dihydroartemisinin in animal and human plasma SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE HPLC-ECD; LC-MS/MS; artesunate; dihydroartemisinin; validation ID PERFORMANCE LIQUID-CHROMATOGRAPHY; SUPERCRITICAL-FLUID CHROMATOGRAPHY; MASS-SPECTROMETRY; METABOLITE DIHYDROARTEMISININ; ANTIMALARIAL ARTEETHER; ARTEMISININ; PHARMACOKINETICS; TOXICOKINETICS; SPECTROSCOPY; MALARIA AB High-performance liquid chromatography with reductive electrochemical detection (HPLC-ECD) method has been used for assaying artemisinins since 1985. Although the methods have been remarkably improved, tandem mass spectrometry (LC-MS/MS) systems with significant advantages have gradually replaced HPLC-ECD to analyze artesunate and dihydroartemisinin in plasma. In the present study, the two methods were evaluated for linearity, quantitation limits, selectivity, precision, and accuracy. The HPLC-ECD performed well in terms of various validation parameters, and showed a good agreement with the LC-MS/MS when calibrated in plasma. However, the major benefit of LC-MS/MS is that it requires only one-tenth the plasma volume needed by HPLC-ECD assay. Published by Elsevier B.V. C1 [Gu, Yuanchao; Li, Qigui; Melendez, Victor; Weina, Peter] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Li, QG (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Dept Pharmacol, 503 Robert Grant Ave, Silver Spring, MD 20307 USA. EM qigui.li@na.amedd.army.mil RI Weina, Peter/A-2120-2011 NR 24 TC 24 Z9 26 U1 5 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD MAY 15 PY 2008 VL 867 IS 2 BP 213 EP 218 DI 10.1016/j.jchromb.2008.04.019 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 311MW UT WOS:000256605300007 PM 18468497 ER PT J AU Wolfenstine, J Allen, JL AF Wolfenstine, J. Allen, J. L. TI Electrical conductivity and charge compensation in Ta doped Li4Ti5O12 SO JOURNAL OF POWER SOURCES LA English DT Article DE anode; conductivity; defects; sintering; Li4Ti5O12 ID LITHIUM-ION BATTERIES; ELECTROCHEMICAL PERFORMANCE; MGAL2O4; OXIDES; MODEL AB Ta doping in Li4Ti5O12 (Li4Ti4.95Ta0.05O12) as function of different heat-treat atmospheres (oxidizing/reducing) was investigated and compared to Li4Ti5O12 to determine its effect on ionic/electronic conductivity and the charge compensating defects. Under oxidizing conditions Li4Ti4.95Ta0.05O12 was primarily an ionic conductor where the extra charge of Ta was compensated by Ti vacancies. Under reducing conditions Li4Ti4.95Ta0.05O12 was primarily an electronic conductor where the extra charge of Ta was compensated by an electron. The charge compensating defects were confirmed by sintering data. Published by Elsevier B.V. C1 [Wolfenstine, J.; Allen, J. L.] USA, AMSRD ARL SE DC, Res Lab, Adelphi, MD 20783 USA. RP Wolfenstine, J (reprint author), USA, AMSRD ARL SE DC, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jwolfenstine@arl.army.mil NR 29 TC 146 Z9 158 U1 10 U2 73 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD MAY 15 PY 2008 VL 180 IS 1 BP 582 EP 585 DI 10.1016/j.jpowsour.2008.02.019 PG 4 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 303VV UT WOS:000256069900072 ER PT J AU Zhang, SS AF Zhang, Sheng Shui TI LiBF3Cl as an alternative salt for the electrolyte of Li-ion batteries SO JOURNAL OF POWER SOURCES LA English DT Article DE LiBF3Cl; LiBF4; electrolyte; solid electrolyte interphase; Li-ion battery ID LOW-TEMPERATURE PERFORMANCE; ALUMINUM CORROSION; IMPEDANCE; CELLS; INTERFACE AB LiBF3Cl was synthesized by reacting BF3 etherate and LiCl in an organic media, and evaluated as a salt for the electrolyte of Li-ion batteries. XRD results showed that LiBF3Cl has the same crystallographic structure as LiBF4 except for little difference in the lattice parameter. With a 3:7 (w/w) solvent blend of ethylene carbonate and ethyl methyl carbonate, LiBF3Cl electrolyte was found to have lower liquidus temperature than LiBF4 analogue either due to its higher solubility or due to its higher tendency in forming a super-cooling solution, which was related to the less symmetry of BF3Cl- anion. Meanwhile, LiBF3Cl electrolyte displayed excellent ability in passivating Al at high potentials due to the similar chemical composition of LiBF3Cl and LiBF4. Most importantly, the LiBF3Cl electrolyte was superior to the LiBF4 electrolyte in facilitating the formation of solid electrolyte interphase (SEI) on graphite electrode, which not only increased Coulombic efficiencies of the SEI formation, but also prolonged cycle life of the Li-ion batteries. The merits above make LiBF3Cl very promising as an alternative lithium salt for the electrolyte of Li-ion batteries. Published by Elsevier B.V. C1 USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 21 TC 19 Z9 24 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAY 15 PY 2008 VL 180 IS 1 BP 586 EP 590 DI 10.1016/j.jpowsour.2008.02.018 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 303VV UT WOS:000256069900073 ER PT J AU Hoge, CW Engel, CC Castro, CA AF Hoge, Charles W. Engel, Charles C. Castro, Carl A. TI Mild traumatic brain injury in US soldiers returning from Iraq - Reply SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Silver Spring, MD 20910 USA. [Castro, Carl A.] US Army Med Res & Materiel Command, Ft Detrick, MD 21702 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil NR 5 TC 1 Z9 1 U1 0 U2 4 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAY 15 PY 2008 VL 358 IS 20 BP 2179 EP 2179 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 300TY UT WOS:000255849300020 ER PT J AU Pritchett, TM Sun, WF Guo, FQ Zhang, BG Ferry, MJ Rogers-Haley, JE Shensky, W Mott, AG AF Pritchett, Timothy M. Sun, Wenfang Guo, Fengqi Zhang, Bingguang Ferry, Michael J. Rogers-Haley, Joy E. Shensky, William, III Mott, Andrew G. TI Excited-state absorption in a terpyridyl platinum(II) pentynyl complex SO OPTICS LETTERS LA English DT Article ID ACETYLIDE COMPLEXES; PHOTOPHYSICS AB The singlet excited-state lifetime of a terpyridyl platinum(II) pentynyl complex was determined to be 268 +/- 87 ps by fitting femtosecond transient absorption data, the triplet excited-state lifetime was found to be 62 ns by fitting nanosecond transient absorption decay data, and the triplet quantum yield was measured to be 0.16. A ground-state absorption cross section of 2.5 X 10(-19) cm(2) at 532 nm was deduced from UV vis absorption data. Excited-state absorption cross sections of 3.5 X 10(-17) cm(2) (singlet) and 4.5 X 10(-11) cm(2) (triplet) were obtained by using a five-level dynamic model to fit open-aperture Z scans at picosecond and nanosecond pulse widths and a variety of pulse energies. (C) 2008 Optical Society of America. C1 [Pritchett, Timothy M.; Ferry, Michael J.; Mott, Andrew G.] US Army Res Lab, AMSRD ARL SE EM, Adelphi, MD 20783 USA. [Sun, Wenfang; Guo, Fengqi; Zhang, Bingguang] N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58105 USA. [Rogers-Haley, Joy E.] Universal Energy Syst Inc, Dayton, OH 45432 USA. [Rogers-Haley, Joy E.] USAF, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA. [Shensky, William, III] LLC, Gen Tech Serv, Wall Township, NJ 07719 USA. RP Pritchett, TM (reprint author), US Army Res Lab, AMSRD ARL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM timothy.pritchett1@us.army.mil RI Shensky, William/J-7012-2014 NR 16 TC 29 Z9 29 U1 0 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD MAY 15 PY 2008 VL 33 IS 10 BP 1053 EP 1055 DI 10.1364/OL.33.001053 PG 3 WC Optics SC Optics GA 310HW UT WOS:000256520500006 PM 18483509 ER PT J AU Tschudi, MA Maslanik, JA Perovich, DK AF Tschudi, Mark A. Maslanik, James A. Perovich, Donald K. TI Derivation of melt pond coverage on Arctic sea ice using MODIS observations SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE sea ice; Arctic; MODIS; UAV ID ATMOSPHERIC CORRECTION; SUMMER; ALBEDO; VARIABILITY; AEROSONDES; EVOLUTION; AIRCRAFT; RADAR; VIDEO AB The fort-nation of meltponds on the surface of sea ice during summer is one of the main factors affecting variability in surface albedo over the ice cover. However, observations of the spatial extent of ponding are rare. To address this, a MODIS surface reflectance product is used to derive the daily melt pond cover over sea ice in the Beaufort/Chukchi Sea region through the summer of 2004. For this region, the estimated pond cover increased rapidly during the first 20 days of melt from 10% to 40%. Fluctuations in pond cover occurred through summer, followed by a more gradual decrease through late August to 10%. The rapid initial increase in pond cover occurred later as latitude increased and melt progressed northward. A surface campaign at Barrow in June 2004 provided pond and ice spectral reflectance needed by the MODIS algorithm to deduce pond coverage. Although individual pond and ice reflectance varies within the comparatively small region of measurement, the mean values used within the algorithm ensured that relevant values (i.e. concurrent with satellite observations) were being applied. Aerosonde unpiloted aerial vehicles (UAVs) were deployed in June 2004 from Barrow, Alaska, to photograph the sea ice so melt pond cover could be estimated. Although the agreement between derived pond cover from UAV photos and estimates from MODIS varies, the mean estimates and distribution of pond coverages are similar, suggesting that the MODIS technique is useful for estimating pond coverage throughout the region. It is recommended that this technique be applied to the entire Arctic through the melt season. (C) 2008 Elsevier Inc. All rights reserved. C1 [Tschudi, Mark A.; Maslanik, James A.] Univ Colorado, Dept Aerosp Engn Sci, CCAR, Boulder, CO 80309 USA. [Perovich, Donald K.] USACE Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Tschudi, MA (reprint author), Univ Colorado, Dept Aerosp Engn Sci, CCAR, Boulder, CO 80309 USA. EM marktschudi@gmail.com; james.maslanik@colorado.edu; donald.k.perovich@erdc.usace.army.mil NR 39 TC 52 Z9 54 U1 3 U2 22 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 EI 1879-0704 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD MAY 15 PY 2008 VL 112 IS 5 BP 2605 EP 2614 DI 10.1016/j.rse.2007.12.009 PG 10 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 293YG UT WOS:000255370700052 ER PT J AU Ramanathan, S Patibandla, S Bandyopadhyay, S Anderson, J Edwards, JD AF Ramanathan, Sivakumar Patibandla, Sridhar Bandyopadhyay, Supriyo Anderson, John Edwards, Jarrod D. TI Fluorescence spectroscopy of electrochemically self-assembled ZnSe and Mn : ZnSe nanowires SO NANOTECHNOLOGY LA English DT Article ID OPTICAL-PROPERTIES; QUANTUM-DOT; NANOCRYSTALS; GROWTH; ARRAY; PHOTOLUMINESCENCE; LUMINESCENCE; FABRICATION; WIRES AB We report room temperature fluorescence spectroscopy (FL) studies of ZnSe and Mn-doped ZnSe nanowires of different diameters (10, 25, 50 nm) produced by an electrochemical self-assembly technique. All samples exhibit increasing blue-shift in the band edge fluorescence with decreasing wire diameter because of quantum confinement. The 10 nm ZnSe nanowires show four distinct emission peaks due to band-to-band recombination, exciton recombination, recombination via surface states and via band gap (trap) states. The exciton binding energy in these nanowires exhibits a giant increase (similar to 10-fold) over the bulk value due to quantum confinement, since the effective wire radius (taking into account side depletion) is smaller than the exciton Bohr radius in bulk ZnSe. The 25 and 50 nm diameter wires show only a single FL peak due to band-to-band electron-hole recombination. In the case of Mn-doped ZnSe nanowires, the band edge luminescence in 10 nm samples is significantly quenched by Mn doping but not the exciton luminescence, which remains relatively unaffected. We observe additional features due to Mn(2+) ions. The spectra also reveal that the emission from Mn2+ states increases in intensity and is progressively red-shifted with increasing Mn concentration. C1 [Ramanathan, Sivakumar; Patibandla, Sridhar; Bandyopadhyay, Supriyo] Virginia Commonwealth Univ, Dept Elect & Comp Engn, Richmond, VA 23284 USA. [Anderson, John; Edwards, Jarrod D.] USA, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. RP Bandyopadhyay, S (reprint author), Virginia Commonwealth Univ, Dept Elect & Comp Engn, Med Coll Virginia Campus, Richmond, VA 23284 USA. EM sbandy@vcu.edu NR 26 TC 7 Z9 7 U1 2 U2 12 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 J9 NANOTECHNOLOGY JI Nanotechnology PD MAY 14 PY 2008 VL 19 IS 19 AR 195601 DI 10.1088/0957-4484/19/19/195601 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 290BO UT WOS:000255097900009 PM 21825716 ER PT J AU Angov, E Hillier, CJ Kincaid, RL Lyon, JA AF Angov, Evelina Hillier, Collette J. Kincaid, Randall L. Lyon, Jeffrey A. TI Heterologous Protein Expression Is Enhanced by Harmonizing the Codon Usage Frequencies of the Target Gene with those of the Expression Host SO PLOS ONE LA English DT Article AB Synonymous codon replacement can change protein structure and function, indicating that protein structure depends on DNA sequence. During heterologous protein expression, low expression or formation of insoluble aggregates may be attributable to differences in synonymous codon usage between expression and natural hosts. This discordance may be particularly important during translation of the domain boundaries ( link/end segments) that separate elements of higher ordered structure. Within such regions, ribosomal progression slows as the ribosome encounters clusters of infrequently used codons that preferentially encode a subset of amino acids. To replicate the modulation of such localized translation rates during heterologous expression, we used known relationships between codon usage frequencies and secondary protein structure to develop an algorithm ("codon harmonization'') for identifying regions of slowly translated mRNA that are putatively associated with link/end segments. It then recommends synonymous replacement codons having usage frequencies in the heterologous expression host that are less than or equal to the usage frequencies of native codons in the native expression host. For protein regions other than these putative link/end segments, it recommends synonymous substitutions with codons having usage frequencies matched as nearly as possible to the native expression system. Previous application of this algorithm facilitated E. coli expression, manufacture and testing of two Plasmodium falciparum vaccine candidates. Here we describe the algorithm in detail and apply it to E. coli expression of three additional P. falciparum proteins. Expression of the "recoded'' genes exceeded that of the native genes by 4- to 1,000-fold, representing levels suitable for vaccine manufacture. The proteins were soluble and reacted with a variety of functional conformation-specific mAbs suggesting that they were folded properly and had assumed native conformation. Codon harmonization may further provide a general strategy for improving the expression of soluble functional proteins during heterologous expression in hosts other than E. coli. C1 [Angov, Evelina; Hillier, Collette J.; Lyon, Jeffrey A.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Kincaid, Randall L.] Veritas Inc, Rockville, MD USA. RP Angov, E (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. EM Evelina.angov@us.army.mil FU United States Agency for International Development [936 6001, AAG-P-00-98-00006, AAG-P-00-98-00005]; United States Army Medical Research and Materiel Command FX This work was supported by the United States Agency for International Development, Project Number 936 6001, Award Number AAG-P-00-98-00006, Award Number AAG-P-00-98-00005, and by the United States Army Medical Research and Materiel Command. NR 47 TC 112 Z9 113 U1 4 U2 19 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 14 PY 2008 VL 3 IS 5 AR e2189 DI 10.1371/journal.pone.0002189 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 390OE UT WOS:000262172800053 PM 18478103 ER PT J AU Kubicki, JD Paul, KW Sparks, DL AF Kubicki, James D. Paul, Kristian W. Sparks, Donald L. TI Periodic density functional theory calculations of bulk and the (010) surface of goethite SO GEOCHEMICAL TRANSACTIONS LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; INTRINSIC PROTON AFFINITY; AUGMENTED-WAVE METHOD; ALPHA-FEOOH; AB-INITIO; PHOSPHATED GOETHITE; METAL (HYDR)OXIDES; NEUTRON-SCATTERING; GAMMA-FEOOH; ADSORPTION AB Background: Goethite is a common and reactive mineral in the environment. The transport of contaminants and anaerobic respiration of microbes are significantly affected by adsorption and reduction reactions involving goethite. An understanding of the mineral-water interface of goethite is critical for determining the molecular-scale mechanisms of adsorption and reduction reactions. In this study, periodic density functional theory (DFT) calculations were performed on the mineral goethite and its (010) surface, using the Vienna Ab Initio Simulation Package (VASP). Results: Calculations of the bulk mineral structure accurately reproduced the observed crystal structure and vibrational frequencies, suggesting that this computational methodology was suitable for modeling the goethite-water interface. Energy-minimized structures of bare, hydrated (one H(2)O layer) and solvated (three H(2)O layers) (010) surfaces were calculated for 1 x 1 and 3 x 3 unit cell slabs. A good correlation between the calculated and observed vibrational frequencies was found for the 1 x 1 solvated surface. However, differences between the 1 x 1 and 3 x 3 slab calculations indicated that larger models may be necessary to simulate the relaxation of water at the interface. Comparison of two hydrated surfaces with molecularly and dissociatively adsorbed H2O showed a significantly lower potential energy for the former. Conclusion: Surface Fe-O and (Fe) O-H bond lengths are reported that may be useful in surface complexation models (SCM) of the goethite (010) surface. These bond lengths were found to change significantly as a function of solvation (i.e., addition of two extra H(2)O layers above the surface), indicating that this parameter should be carefully considered in future SCM studies of metal oxide-water interfaces. C1 [Kubicki, James D.] Penn State Univ, Dept Geosci, University Pk, PA 16802 USA. [Kubicki, James D.] Penn State Univ, Earth & Environm Syst Inst, University Pk, PA 16802 USA. [Paul, Kristian W.] USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. [Sparks, Donald L.] Univ Delaware, Dept Plant & Soil Sci, Newark, DE 19716 USA. RP Kubicki, JD (reprint author), Penn State Univ, Dept Geosci, University Pk, PA 16802 USA. EM kubicki@geosc.psu.edu; kristian.paul@arl.army.mil; dlsparks@UDel.edu RI Kubicki, James/I-1843-2012 OI Kubicki, James/0000-0002-9277-9044 NR 51 TC 36 Z9 38 U1 7 U2 53 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1467-4866 J9 GEOCHEM T JI Geochem. Trans. PD MAY 13 PY 2008 VL 9 AR 4 DI 10.1186/1467-4866-9-4 PG 16 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 312OZ UT WOS:000256682000001 PM 18477389 ER PT J AU Nagarajan, S Kumar, J Bruno, FF Samuelson, LA Nagarajan, R AF Nagarajan, Subhalakshmi Kumar, Jayant Bruno, Ferdinando F. Samuelson, Lynne A. Nagarajan, Ramaswamy TI Biocatalytically synthesized poly(3,4-ethylenedioxythiophene) SO MACROMOLECULES LA English DT Article ID TECHNICAL APPLICATIONS; BIOMIMETIC SYNTHESIS; CONDUCTIVE COATINGS; ENZYMATIC-SYNTHESIS; 3,4-ETHYLENEDIOXYTHIOPHENE AB Over the past decade, poly(3,4-ethylenedioxythiophene) (PEDOT) has been one of the widely investigated conjugated polymers due to its excellent electro-optical properties. The conventional synthesis of PEDOT/PSS involves oxidation of EDOT using strong oxidants in aqueous polystyrenesulfonate (SPS) solution. The low pH conditions and strong oxidants render this synthetic protocol unsuitable for use of PEDOT in applications Such as biosensing. For the purpose of expanding the utility of PEDOT in these applications, it is important to develop a route that can provide the possibility of synthesizing PEDOT in the presence of the appropriate biological entities. Here we report the use of terthiophene as a radical mediator to synthesize PEDOT/PSS under milder pH conditions using soybean peroxidase (SBP). The oxidation potential of terthiophene is sufficiently low for initiation of the polymerization reaction catalyzed by SBP. The oxidized terthiophene helps the subsequent oxidation of EDOT, thus mediating the polymerization reaction. This novel approach involving the use of conjugated oligomers as redox mediators is generic and vastly expands the types of substrates (thiophenes, pyrroles) that can be polymerized using enzymatic methods and benign conditions. C1 [Nagarajan, Ramaswamy] Univ Massachusetts, Ctr Adv Mat, Dept Plast Engn, Lowell, MA 01854 USA. [Nagarajan, Subhalakshmi] Univ Massachusetts, Ctr Adv Mat, Dept Chem, Lowell, MA USA. [Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Dept Phys, Lowell, MA USA. [Bruno, Ferdinando F.; Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Nagarajan, R (reprint author), Univ Massachusetts, Ctr Adv Mat, Dept Plast Engn, Lowell, MA 01854 USA. EM Ramaswamy_Nagarajan@uml.edu NR 21 TC 38 Z9 38 U1 4 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD MAY 13 PY 2008 VL 41 IS 9 BP 3049 EP 3052 DI 10.1021/ma0717845 PG 4 WC Polymer Science SC Polymer Science GA 297YU UT WOS:000255654100015 ER PT J AU Pickett, CA Jackson, JL Hemann, BA Atwood, JE AF Pickett, Christopher A. Jackson, Jeffrey L. Hemann, Brian A. Atwood, J. Edwin TI Carotid bruits as a prognostic indicator of cardiovascular death and myocardial infarction: a meta-analysis SO LANCET LA English DT Article ID ASYMPTOMATIC CERVICAL BRUIT; LONG-TERM PROGNOSIS; SYMPTOMATIC PATIENTS; SYSTEMATIC REVIEWS; PUBLICATION BIAS; CLINICAL-TRIALS; PRESSURE INDEX; NECK BRUITS; FOLLOW-UP; RISK AB Background Although carotid bruits are deemed to be markers of generalised atherosclerosis, they are poor predictors of cerebrovascular events. We investigated whether a carotid bruit predicts myocardial infarction and cardiovascular death. Methods in this meta-analysis, we searched Medline (1966 to August, 2007) and Embase (1974 to August, 2007) with the terms "carotid" and "bruit". Bibliographies of all the retrieved articles were also searched. Articles were included if they reported the incidence of myocardial infarction or cardiovascular death in adults. Outcome variables were extracted in duplicate and included the rate of myocardial infarction and cardiovascular mortality. Quality of the articles was independently assessed with the Hayden rating scheme. Data were pooled with a random effects model. Findings Of the 22 articles included, 20 (91%) used prospective cohorts. Our analysis included 17295 patients with 62413.5 patient-years of follow-up, with a median sample size of 273 patients (range 38-4736) followed up for 4 years (2-7). The rate of myocardial infarction in patients with carotid bruits was 3.69 (95% CI 2.97-5.40) per 100 patient-years (eight studies) compared with 1.86 (0.24-3.48) per 100 patient-years in those without bruits (two studies). Yearly rates of cardiovascular death were also higher in patients with bruits (16 studies) than in those without (four studies) (2 . 85 [2.16-3.54] per 100 patient-years vs 1 . 11 [0 . 45-1.76] per 100 patient-years). in the four trials in which direct comparisons of patients with and without bruits were possible, the odds ratio for myocardial infarction was 2.15 (1.67-2.78) and for cardiovascular death 2.27 (1.49-3.49). Interpretation Auscultation for carotid bruits in patients at risk for heart disease could help select those who might benefit the most from an aggressive modification strategy for cardiovascular risk. C1 [Pickett, Christopher A.; Jackson, Jeffrey L.; Hemann, Brian A.; Atwood, J. Edwin] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Hemann, Brian A.; Atwood, J. Edwin] Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. [Jackson, Jeffrey L.; Atwood, J. Edwin] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Pickett, CA (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM christopher.pickett1@us.army.mil NR 49 TC 53 Z9 53 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD MAY 10 PY 2008 VL 371 IS 9624 BP 1587 EP 1594 DI 10.1016/S0140-6736(08)60691-1 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 298VO UT WOS:000255715400026 PM 18468542 ER PT J AU McGlynn, KA Quraishi, SM Graubard, BI Weber, JP Rubertone, MV Erickson, RL AF McGlynn, Katherine A. Quraishi, Sabah M. Graubard, Barry I. Weber, Jean-Philippe Rubertone, Mark V. Erickson, Ralph L. TI Persistent organochlorine pesticides and risk of testicular germ cell tumors SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article ID ENVIRONMENTAL DDT EXPOSURE; POLYCHLORINATED-BIPHENYLS; SERUM-LEVEL; YOUNG MEN; CANCER; CRYPTORCHIDISM; ESTROGENS; P,P'-DDE; HEALTH; TESTIS AB Background Exposure to endocrine-disrupting chemicals, such as persistent organochlorine pesticides, has been suggested to increase the risk of testicular germ cell tumors (TGCTs). Methods To study the relationship of POP exposure to TGCT risk, prediagnostic serum samples from 754 case subjects and 928 control subjects enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study were analyzed for cis-nonachlor, trans-nonachlor, oxychlordane, total chlordanes, beta-hexachlorocyclohexane, mirex, p,p '-dichlorodiphenyldichloroethylene (p,p '-DDE), and p,p '-dichlorodiphenyltrichloroethane. Adjusted odds ratios (ORs) and their associated 95% confidence intervals (CIs) for the risk of TGCT overall and for the histological subgroups, seminoma and nonseminoma, were estimated using multivariable logistic regression. All statistical tests were two-sided. Results TGCT risk was statistically significantly associated with higher plasma levels of p,p '-DDE (for highest quartile [Q4] vs lowest quartile [Q1], OR = 1.71, 95% CI = 1.23 to 2.38, P-trend = .0002) and of two chlordane components, cis-nonachlor (Q4 vs Q1, OR = 1.56, 95% CI = 1.11 to 2.18, P-trend = .009) and trans-nonachlor (Q4 vs Q1, OR = 1.46, 95% CI = 1.07 to 2.00, P-trend = .026). Seminoma risk was statistically significantly associated with p,p '-DDE (Q4 vs Q1, OR = 1.91, 95% CI = 1.22 to 2.99, P-trend = .0008), cis-nonachlor (Q4 vs Q1, OR = 1.93, 95% CI = 1.27 to 2.93, P-trend = .0045), trans-nonachlor (Q4 vs Q1, OR = 1.72, 95% CI = 1.11 to 2.67, P-trend = .033), and a chlordane metabolite, oxychlordane (Q4 vs Q1, OR = 1.64, 95% CI = 1.04 to 2.60, P-trend = .048), whereas nonseminoma risk showed a statistically significant association with p,p '-DDE only (Q4 vs Q1, OR = 1.63, 95% CI = 1.10 to 2.42, P-trend = .0044). Conclusions Increased exposure to p,p'-DDE may be associated with the risk of both seminomatous and nonseminomatous TGCTs, whereas exposure to chlordane compounds and metabolites may be associated with the risk of seminoma. Because evidence suggests that TGCT is initiated in very early life, it is possible that exposure to these persistent organic pesticides during fetal life or via breast feeding may increase the risk of TGCT in young men. C1 [McGlynn, Katherine A.; Quraishi, Sabah M.; Graubard, Barry I.] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Weber, Jean-Philippe] Inst Natl Sante Publ Quebec, Toxicol Ctr, Quebec City, PQ, Canada. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Washington, DC 20310 USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, GEIS, Div Prevent Med, Silver Spring, MD USA. RP McGlynn, KA (reprint author), NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, EPS Ste 550,6120 Execut Blvd, Rockville, MD 20852 USA. EM mcglynnk@mail.nih.gov NR 39 TC 80 Z9 80 U1 0 U2 12 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD MAY 7 PY 2008 VL 100 IS 9 BP 663 EP 671 DI 10.1093/jnci/djn101 PG 9 WC Oncology SC Oncology GA 299LN UT WOS:000255757200014 PM 18445826 ER PT J AU Smith, TA AF Smith, Troy Alvin TI Numerical stability analysis for the explicit high-order finite difference analysis of rotationally symmetric shells SO JOURNAL OF SOUND AND VIBRATION LA English DT Article ID ELASTIC SHELLS; REVOLUTION; VIBRATION; EQUATIONS; LOADINGS AB A numerical stability analysis has been formulated to accompany the already developed explicit high-order finite difference analysis of rotationally symmetric shells subjected to time-dependent impulsive loadings. This already developed analysis utilizes a constant nodal point spacing for the spatial finite difference mesh, with the governing field differential equations formulated in terms of the transverse, meridional, and circumferential displacements as the fundamental variables. The remaining quantities which enter into the natural boundary conditions at each edge of the shell are incorporated into the complete system of equations by defining those quantities at each boundary in terms of the displacements. Surface loadings and inertia forces in each of the three displacement directions of the shell have been considered in the governing equations. Ordinary finite difference representations are used for the time derivatives. All loadings and dependent variables in the circumferential direction of the shell are expressed in Fourier series expansions. The complete system of equations is solved implicitly for the first time increment, while explicit relations are used to determine the three primary displacements within the boundary edges of the shell for the second and succeeding time increments. Separate implicit solutions at each boundary are then used to determine the remaining unspecified primary variables on and outside the boundaries. Subsequently, the remaining primary variables within the boundary edges of the shell and all secondary variables are determined explicitly. Numerical stability (or instability) of numerical solutions for given choices of spatial and time increments is determined by evaluation of the eigenvalues of the explicit coefficient matrix and comparing the maximum eigenvalue with the requirements of a stability criterion developed before by the author. Solutions for typical shells and loadings together with results of stability analyses have been included, and comparisons of the stability requirements and solutions with the requirements and solutions based upon ordinary spatial finite difference representations are included. (C) 2008 Elsevier Ltd. All rights reserved. C1 USA, Res Dev & Engn Command, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Smith, TA (reprint author), USA, Res Dev & Engn Command, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. NR 29 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-460X J9 J SOUND VIB JI J. Sound Vibr. PD MAY 6 PY 2008 VL 312 IS 3 BP 418 EP 441 DI 10.1016/j.jsv.2007.07.093 PG 24 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 292ZM UT WOS:000255304600004 ER PT J AU Birkenheuer, AJ Marr, HS Warren, C Acton, AE Mucker, EM Humphreys, JG Tucker, MD AF Birkenheuer, Adam J. Marr, Henry S. Warren, Camille Acton, Anne E. Mucker, Eric M. Humphreys, Jan G. Tucker, Melissa D. TI Cytauxzoon felis infections are present in bobcats (Lynx rufus) in a region where cytauxzoonosis is not recognized in domestic cats SO VETERINARY PARASITOLOGY LA English DT Article DE cytauxzoonosis; piroplasmosis; Cytauxzoon felis; bobcats; PCR; tick ID FATAL CYTAUXZOONOSIS; BLOOD-SAMPLES; DISEASE; TICKS; DNA; PCR AB This study was performed to determine the prevalence of Cytauxzoon felis (C felis) infections in bobcats (Lynx rufus) from a region where C. felis is recognized in domestic cats, North Carolina (NC), and a region where C. felis is not recognized in domestic cats, Pennsylvania (PA). Samples from NC (n = 32) were obtained post-mortem via cardiac puncture from legally trapped bobcats. Samples from PA (n = 70) were collected post-mortem onto Nobuto blood collecting strips by the PA Game Commission. Each sample was tested using a C felis specific PCR assay as well as a PCR assay targeting host DNA to rule out the presence of PCR inhibitors. Three samples were excluded due to the presence of PCR inhibitors. Thirty-three percent (10/30) of the samples from NC and 7% (5/69) of the samples from PA tested positive for the presence of C. felis. The proportion of C. felis positive bobcats from NC was significantly different than that from PA (P < 0.005). Despite the lower prevalence of C. felis infections in bobcats from PA this finding is unique and indicates the potential for C. felis infections in domestic cats in the northeastern USA if the appropriate tick vectors are present. Veterinary practitioners in PA should be on alert for cytauxzoonosis in domestic cats. Further studies about the epidemiology and transmission of C. felis infections among both domestic cats and bobcats are needed. (C) 2008 Elsevier B.V. All rights reserved. C1 [Birkenheuer, Adam J.; Marr, Henry S.; Warren, Camille; Acton, Anne E.; Tucker, Melissa D.] N Carolina State Univ, Coll Vet Med, Dept Clin Sci, Raleigh, NC 27606 USA. [Mucker, Eric M.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Humphreys, Jan G.] Indiana Univ Penn, Dept Biol, Indiana, PA 15705 USA. RP Birkenheuer, AJ (reprint author), N Carolina State Univ, Coll Vet Med, Dept Clin Sci, 4700 Hillsborough St, Raleigh, NC 27606 USA. EM ajbirken@ncsu.edu NR 16 TC 17 Z9 17 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4017 J9 VET PARASITOL JI Vet. Parasitol. PD MAY 6 PY 2008 VL 153 IS 1-2 BP 126 EP 130 DI 10.1016/j.vetpar.2008.01.020 PG 5 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA 298DM UT WOS:000255666600016 PM 18295403 ER PT J AU Cole, MW Weiss, CV Ngo, E Hirsch, S Coryell, LA Alpay, SP AF Cole, M. W. Weiss, C. V. Ngo, E. Hirsch, S. Coryell, L. A. Alpay, S. P. TI Microwave dielectric properties of graded barium strontium titanate films SO APPLIED PHYSICS LETTERS LA English DT Article ID PULSED-LASER DEPOSITION; THIN-FILMS; CERAMICS; DEVICES; PLANAR AB Compositionally graded barium strontium titanate (Ba(x)Sr(1-x)TiO(3) or BST) multilayers (5 mol % MgO doped and undoped) were prepared via metallo-organic solution deposition on Pt-Si substrates and characterized electrically at 0.5, 5, and 10 GHz. For the undoped BST multilayers, the small-signal dielectric response, tunability, and the loss tangent at 10 GHz were 261, 25% at 1778 kV/cm, and 0.078, respectively. On the other hand, the Mg-doped BST multilayers displayed a significant improvement in the loss characteristics at 10 GHz (0.039) but the dielectric response and its tunability were lower (189 and 15%, respectively, at 1778 kV/cm). (c) 2008 American Institute of Physics. C1 [Weiss, C. V.; Alpay, S. P.] Univ Connecticut, Mat Sci & Engn Program, Storrs, CT 06269 USA. [Cole, M. W.; Ngo, E.; Hirsch, S.] USA, Res Lab, Act Mat Res Grp, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Weiss, C. V.; Alpay, S. P.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Coryell, L. A.] USA, Commun & Elect Res Dev & Engn Ctr, Space & Terr Commun Directorate, Ft Monmouth, NJ 07703 USA. RP Alpay, SP (reprint author), Univ Connecticut, Mat Sci & Engn Program, Storrs, CT 06269 USA. EM mcole@arl.army.mil; p.alpay@ims.uconn.edu RI Alpay, Pamir/E-2666-2013 NR 21 TC 48 Z9 48 U1 2 U2 18 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 5 PY 2008 VL 92 IS 18 AR 182906 DI 10.1063/1.2919080 PG 3 WC Physics, Applied SC Physics GA 309UM UT WOS:000256485700049 ER PT J AU Vijaya, Y Popuri, SR Boddu, VM Krishnaiah, A AF Vijaya, Y. Popuri, Srinivasa R. Boddu, Veera M. Krishnaiah, A. TI Modified chitosan and calcium alginate biopolymer sorbents for removal of nickel (II) through adsorption SO CARBOHYDRATE POLYMERS LA English DT Article DE biosorption; nickel; chitosan; calcium alginate; silica ID AQUEOUS-SOLUTIONS; METAL-IONS; SACCHAROMYCES-CEREVISIAE; MARINE-ALGAE; BIOSORPTION; CADMIUM; KINETICS; RECOVERY; CHROMIUM(VI); COPPER(II) AB Removal of nickel (II) from aqueous solutions through adsorption on to biopolymer sorbents, such as calcium alginate (CA), chitosan coated calcium alginate (CCCA) and chitosan coated silica (CCS), was studied using equilibrium batch and column flow techniques. The biosorbents were characterized by FTIR, SEM, TGA and surface area analysis. The extent of adsorption was found to be a function of the pH of the solution, contact time, sorbate concentration and adsorbent dose. The optimum pH was found to be 5.0. The adsorption of Ni (II) ions on CA was comparatively higher than CCCA and CCS. Adsorption of Ni (II) on to the biopolymers followed pseudo-second order kinetics. The equilibrium adsorption data for Ni (11) on CA, CCCA and CCS were fitted to Freundlich, and Langmuir Isotherms. The maximum monolayer adsorption capacity of the biosorbents (CA, CCCA and CCS), as obtained from Langmuir adsorption isotherm, was found to be 310.4, 222.2 and 254.3 mg/g, respectively. Breakthrough curves were obtained for adsorption of Ni (11) on all the three adsorbents through column flow technique. The Ni (11) loaded biosorbents were regenerated using 0.1 M EDTA solution. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Vijaya, Y.; Krishnaiah, A.] Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Lab, Tirupati 517502, Andhra Pradesh, India. [Popuri, Srinivasa R.] Natl Chung Hsing Univ, Dept Chem, Taichung 40227, Taiwan. [Boddu, Veera M.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Krishnaiah, A (reprint author), Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Lab, Tirupati 517502, Andhra Pradesh, India. EM abburikrishnaiah@gmail.com RI Dr. Vijaya, Yarramuthi/H-5801-2011 NR 41 TC 144 Z9 150 U1 7 U2 41 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0144-8617 J9 CARBOHYD POLYM JI Carbohydr. Polym. PD MAY 5 PY 2008 VL 72 IS 2 BP 261 EP 271 DI 10.1016/j.carbpol.2007.08.010 PG 11 WC Chemistry, Applied; Chemistry, Organic; Polymer Science SC Chemistry; Polymer Science GA 270GR UT WOS:000253709700009 ER PT J AU Vecherin, SN Ostashev, VE Wilson, DK AF Vecherin, Sergey N. Ostashev, Vladimir E. Wilson, D. Keith TI Three-dimensional acoustic travel-time tomography of the atmosphere SO ACTA ACUSTICA UNITED WITH ACUSTICA LA English DT Article ID DEPENDENT STOCHASTIC INVERSION; BOUNDARY-LAYER; SURFACE-LAYER; PROPAGATION; TURBULENCE; SOUND AB Acoustic travel-time tomography is a remote technique that can be used for reconstruction of temperature and wind velocity fields in the atmosphere. In the literature, results of two-dimensional tomography of the atmosphere have been reported so far. This paper presents an algorithm for reconstruction of temperature and wind velocity fields in three-dimensional tomography. In the algorithm, stratification of the atmosphere is taken into account explicitly. This allows high accurate reconstruction of stratified mean temperature and wind velocity fields. The fields of fluctuations are reconstructed with the use of three-dimensional time-dependent stochastic inversion. Estimation of the errors of reconstruction is also presented. A numerical experiment with large-eddy simulation is used to confirm the efficiency of the developed theory. C1 [Vecherin, Sergey N.; Ostashev, Vladimir E.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. [Ostashev, Vladimir E.] NOAA, Earth Syst Res Lab, Boulder, CO 80305 USA. [Wilson, D. Keith] USA, Engn Res & Dev Ctr, Hanover, NH 03755 USA. RP Vecherin, SN (reprint author), New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 29 TC 12 Z9 13 U1 1 U2 6 PU S HIRZEL VERLAG PI STUTTGART PA POSTFACH 10 10 61, D-70 009 STUTTGART, GERMANY SN 1610-1928 J9 ACTA ACUST UNITED AC JI Acta Acust. United Acust. PD MAY-JUN PY 2008 VL 94 IS 3 BP 349 EP 358 DI 10.3813/AAA.918042 PG 10 WC Acoustics SC Acoustics GA 318UB UT WOS:000257117200002 ER PT J AU Fowler, KR Reese, JP Kees, CE Dennis, JE Kelley, CT Miller, CT Audet, C Booker, AJ Couture, G Darwin, RW Farthing, MW Finkel, DE Gablonsky, JM Gray, G Kolda, TG AF Fowler, K. R. Reese, J. P. Kees, C. E. Dennis, J. E., Jr. Kelley, C. T. Miller, C. T. Audet, C. Booker, A. J. Couture, G. Darwin, R. W. Farthing, M. W. Finkel, D. E. Gablonsky, J. M. Gray, G. Kolda, T. G. TI Comparison of derivative-free optimization methods for groundwater supply and hydraulic capture community problems SO ADVANCES IN WATER RESOURCES LA English DT Article DE sampling methods; genetic algorithm; local minima; nondifferentiable objective function ID PARALLEL PATTERN SEARCH; INTERIOR-POINT METHOD; GENETIC ALGORITHM; CONSTRAINED OPTIMIZATION; NONLINEAR OPTIMIZATION; OPTIMAL-DESIGN; CONVERGENCE; MANAGEMENT; SYSTEMS AB Management decisions involving groundwater supply and remediation often rely on optimization techniques to determine an effective strategy. We introduce several derivative-free sampling methods for solving constrained optimization problems that have not yet been considered in this field, and we include a genetic algorithm for completeness. Two well-documented community problems are used for illustration purposes: a groundwater supply problem and a hydraulic capture problem. The community problems were found to be challenging applications due to the objective functions being nonsmooth, nonlinear, and having many local minima. Because the results were found to be sensitive to initial iterates for some methods, guidance is provided in selecting initial iterates for these problems that improve the likelihood of achieving significant reductions in the objective function to be minimized. In addition, we suggest some potentially fruitful areas for future research. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Fowler, K. R.] Clarkson Univ, Dept Math & Comp Sci, Potsdam, NY 13699 USA. [Reese, J. P.] Florida State Univ, Sch Computat Sci, Dirac Sci Lab, Tallahassee, FL 32306 USA. [Kees, C. E.; Farthing, M. W.] USA, Engn Res & Dev Stn, ATTN CEERD HF HG, Vicksburg, MS 39180 USA. [Dennis, J. E., Jr.; Booker, A. J.; Gablonsky, J. M.] Boeing Co, Seattle, WA 98124 USA. [Kelley, C. T.; Darwin, R. W.] N Carolina State Univ, Dept Math, Raleigh, NC 27695 USA. [Miller, C. T.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Audet, C.; Couture, G.] Ecole Polytech, GERAD, Montreal, PQ H3C 3A7, Canada. [Finkel, D. E.] MIT, Lincoln Lab, Lexington, MA 02420 USA. [Gray, G.; Kolda, T. G.] Sandia Natl Labs, Livermore, CA 94551 USA. RP Fowler, KR (reprint author), Clarkson Univ, Dept Math & Comp Sci, Potsdam, NY 13699 USA. EM kfowler@clarkson.edu; jreese@scs.fsu.edu; christopher.e.kees@erdc.usace.army.mil; dennis@rice.edu; tim_kelley@ncsu.edu; casey_miller@unc.edu; charlesa@gerad.ca; andrewj.booker@boeing.com; gilles.couture@gerad.ca; rwdarwin@unity.ncsu.edu; farthing@erdc.usace.army.mil; dfinkel@ll.mit.edu; joerg.m.gablonsky@boeing.com; gagray@sandia.gov; tgkolda@sandia.gov RI Dennis, John/A-6910-2008; Kolda, Tamara/B-1628-2009; Miller, Cass T./I-6613-2012; Audet, Charles/A-7278-2010 OI Kolda, Tamara/0000-0003-4176-2493; Miller, Cass T./0000-0001-6082-9273; Audet, Charles/0000-0002-3043-5393 NR 72 TC 48 Z9 48 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0309-1708 J9 ADV WATER RESOUR JI Adv. Water Resour. PD MAY PY 2008 VL 31 IS 5 BP 743 EP 757 DI 10.1016/j.advwatres.2008.01.010 PG 15 WC Water Resources SC Water Resources GA 302UP UT WOS:000255995600002 ER PT J AU Eichhorn, JH Buckner, L Buckner, SB Beech, DP Harris, KA McClure, DJ Crothers, BA Wilbur, DC AF Eichhorn, John H. Buckner, Leigh Buckner, Sally Beth Beech, David P. Harris, Kimberly A. McClure, Douglas J. Crothers, Barbara A. Wilbur, David C. TI Internet-Based Gynecologic telecytology with remote automated image selection - Results of a first-phase developmental trial SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article; Proceedings Paper CT 95th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY FEB 11-17, 2006 CL Atlanta, GA SP US & Canadian Acad Pathol DE cervical cytology; automated screening; internet; web-based software; telepathology; telecytology ID CERVICAL CYTOLOGY; FEASIBILITY; ACCURACY; CANCER; SYSTEM AB A retrospective set of 191 gynecologic cytology slides with reference interpretations was run on an automated screening device that selects fields of view (FOVs) based on a hierarchical probability of abnormality being present. An interface was developed between the device and a remote server using customized image review software. FOVs were reviewed by 3 cytotechnologists and 3 cytopathologists, and binary triage (unsatisfactoryfor evaluation/ negative for intraepithelial lesion or malignancy [NILM] vs "abnormal" [neither unsatisfactory nor NILM]) and specific interpretations were done.. No morphologic training before FOV review was provided. Three or more reviewers agreed on the correct categorization of NILM/unsatisfactory in 89% (85196) and abnormal in 83% (79195). Three or more reviewers triaged cases to abnormal as follows: atypical squamous cells of uncertain significance, 83% (516); atypical squamous cells, cannot exclude high-grade lesion, 100% (3/3); low-grade squamous intraepithelial lesion (SIL), 83% (52/63); high-grade SIL, 94% (17/18); and atypical glandular cells, 40% (2/5). This procedure may have comparable sensitivity and specificity and possibly could provide effective initial triage to further evaluation. A review of individual cases suggests that further accuracy can be achieved with additional training and experience. C1 [Eichhorn, John H.; Beech, David P.; Wilbur, David C.] Massachusetts Gen Hosp, Cytopathol Div, Boston, MA 02114 USA. [Eichhorn, John H.; Wilbur, David C.] Harvard Univ, Sch Med, Dept Pathol, Cambridge, MA 02138 USA. [Harris, Kimberly A.; McClure, Douglas J.] Ctr Connected Hlth, Boston, MA USA. [Buckner, Leigh; Crothers, Barbara A.] Walter Reed Army Med Ctr, Cytopathol Serv, Washington, DC 20307 USA. [Buckner, Sally Beth] Natl Naval Med Ctr, Bethesda, MD USA. RP Eichhorn, JH (reprint author), Massachusetts Gen Hosp, Cytopathol Div, Warren 105C,55 Fruit St, Boston, MA 02114 USA. NR 11 TC 13 Z9 13 U1 0 U2 0 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD MAY PY 2008 VL 129 IS 5 BP 686 EP 696 DI 10.1309/CRAV16QP8JR5XTPF PG 11 WC Pathology SC Pathology GA 290OW UT WOS:000255133100001 PM 18426727 ER PT J AU Goldberg, ME Laczek, J Napierkowski, JJ AF Goldberg, Michael E. Laczek, Jeffrey Napierkowski, John J. TI Copper deficiency: A rare cause of ataxia following gastric bypass surgery SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Letter ID MYELOPATHY C1 [Goldberg, Michael E.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Laczek, Jeffrey] Walter Reed Army Med Ctr, Dept Gastroenterol, Washington, DC 20307 USA. RP Goldberg, ME (reprint author), Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. NR 6 TC 14 Z9 14 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD MAY PY 2008 VL 103 IS 5 BP 1318 EP 1319 DI 10.1111/j.1572-0241.2007.01782_12.x PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 299IT UT WOS:000255750000043 PM 18477365 ER PT J AU Reeder, TA Mutnick, A AF Reeder, Todd A. Mutnick, Alan TI Pharmacist-versus physician-obtained medication histories SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Article DE documentation; interventions; patient information; pharmacists; physicians ID UNITED-STATES HOSPITALS; DISCREPANCIES; ADMISSION; SERVICES; ERRORS AB Purpose. Physician-obtained medication histories were compared to those obtained by a pharmacist. Methods. Patients whose medication histories were obtained were included in the evaluation if they were at least 18 years old and admitted to an internal medicine service at the University of Virginia Medical Center. Data were collected in two phases. The first 20 patients identified for inclusion were asked to provide an accurate medication history to pilot test the medication history form used by the pharmacist and received no pharmacist follow-up or interventions. In the second phase, patients were asked to provide an accurate medication history, and a pharmacist intervened when discrepancies in the pharmacist-obtained medication history were identified. Results. A total of 55 patients were included in the study. The pharmacists identified 614 medications for these patients, compared with 556 identified by the physicians (p <= 0.001). The pharmacist documented significantly more medication doses and dosage schedules than did physicians (614 versus 446 and 614 versus 404, respectively) (p <= 0.001 for both comparisons). The pharmacist identified 353 discrepancies, including 58 medications not initially identified from the physician-obtained histories. The pharmacist intervened for 161 discrepancies, correcting 142 after contacting the respective physician; 19 medication discrepancies could not be justified by the physician. Conclusion. A total of 353 discrepancies were identified when medication histories obtained by physicians were compared with those obtained by a pharmacist during the study. During the intervention phase, the majority of discrepancies identified were either corrected by the pharmacist after contacting the respective physician or justified by the physician. C1 [Reeder, Todd A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Reeder, Todd A.; Mutnick, Alan] Univ Virginia, Med Ctr, Charlottesville, VA USA. [Mutnick, Alan] Southwest Ohio, Mercy Hlth Partners, Cincinnati, OH USA. RP Reeder, TA (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM todd.reeder@amedd.army.mil NR 9 TC 45 Z9 48 U1 0 U2 3 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD MAY 1 PY 2008 VL 65 IS 9 BP 857 EP 860 DI 10.2146/ajhp070292 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 292XP UT WOS:000255299700011 PM 18436732 ER PT J AU Verma, PS Howard, RS Weiss, BM AF Verma, Pramvir S. Howard, Robin S. Weiss, Brendan M. TI The impact of race on outcomes of autologous transplantation in patients with multiple myeloma SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article ID STEM-CELL TRANSPLANTATION; MONOCLONAL GAMMOPATHY; AFRICAN-AMERICAN; UNITED-STATES; UNDETERMINED SIGNIFICANCE; BREAST-CANCER; SURVIVAL; BLACKS; WHITES; SYSTEM AB Multiple myeloma is the most common hematologic malignancy in African-Americans, with twice the mortality of Caucasians according to population based data. In the pretransplantation era, comparable conventional therapy has resulted in similar outcomes between African-Americans and Caucasians. However, there has been limited data on outcomes after high dose chemotherapy with autologous stem cell transplantation (ASCT). A retrospective analysis of Caucasian (n = 55) and African-American (n = 36) myeloma patients who underwent ASCT in an equal access health care system in the Department of Defense was performed. Presenting demographic variables, pre/post ASCT characteristics, overall mortality and relapse rates after ASCT were obtained. Progression-free survival (PFS) and overall survival (CIS) were calculated by Kaplan-Meier, and compared via log-rank testing. The median age at diagnosis for African-Americans = 52 years, Caucasians = 56 years (P = 0.009). There were no differences in presenting ISS stage, hemoglobin, calcium, or creatinine. African-Americans presented with higher CRP levels (P = 0.005), and a trend for less skeletal involvement (P = 0.10). Response to induction and ASCT was similar. Median PFS was 60.5 months (95% Cl: 31.3-89.8 months) for African-Americans, 43.7 months (95% Cl: 33.9-53.5 months) for Caucasians, HR of 1.3 (95% Cl: 0.7-2.4), P = 0.46. Median CIS was 95.2 months (95% Cl: N/A) for African-Americans, 68.5 months (95% Cl: 14.2-122.9 months) for Caucasians, HR of 1.4 (95% Cl: 0.7-2.9), P = 0.41. In a cohort of myeloma patients who received autologous transplantation in an equal access health care system, there was comparable survival between African-Americans and Caucasians, suggesting that the historical increased mortality for African-Americans may be due to inequalities in access to care. C1 [Verma, Pramvir S.; Weiss, Brendan M.] Walter Reed Army Med Ctr, Dept Med, Hematol & Oncol Serv, Washington, DC 20307 USA. [Howard, Robin S.] Walter Reed Army Med Ctr, Biostat Sect, Dept Clin Invest, Washington, DC 20307 USA. RP Verma, PS (reprint author), Walter Reed Army Med Ctr, Dept Med, Hematol & Oncol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM pramvir@hotmail.com NR 24 TC 18 Z9 18 U1 0 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD MAY PY 2008 VL 83 IS 5 BP 355 EP 358 DI 10.1002/ajh.21139 PG 4 WC Hematology SC Hematology GA 297LQ UT WOS:000255618600003 PM 18186525 ER PT J AU Oakley, F Caswell, S Parks, R AF Oakley, Frances Caswell, Stacie Parks, Rebecca TI Occupational therapists' role on US army and US public health service commissioned corps disaster mental health response teams SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY LA English DT Editorial Material DE disaster response; mental health; occupational therapy C1 [Oakley, Frances] Natl Inst Hlth, US Publ Hlth Serv, Occupat Therapy Sect, Dept Rehabil Med,Mark O Hatfield Clin Res Ctr, Bethesda, MD 20892 USA. [Caswell, Stacie] USA, Ft Hood, TX USA. [Parks, Rebecca] Natl Inst Hlth, US Publ Hlth Serv & Occupat Therapy Educ Coordina, Dept Rehabil Med, Mark O Hatfield Clin Res Ctr, Bethesda, MD USA. RP Oakley, F (reprint author), Natl Inst Hlth, US Publ Hlth Serv, Occupat Therapy Sect, Dept Rehabil Med,Mark O Hatfield Clin Res Ctr, Bethesda, MD 20892 USA. EM foakley@nih.gov FU Intramural NIH HHS [Z99 CL999999] NR 18 TC 2 Z9 2 U1 2 U2 3 PU AMER OCCUPATIONAL THERAPY ASSOC, INC PI BETHESDA PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA SN 0272-9490 J9 AM J OCCUP THER JI Am. J. Occup. Ther. PD MAY-JUN PY 2008 VL 62 IS 3 BP 361 EP 364 PG 4 WC Rehabilitation SC Rehabilitation GA 299NP UT WOS:000255762600012 PM 18557012 ER PT J AU Lee, SE Eick, A Ciminera, P AF Lee, Seung-Eun Eick, Angelia Ciminera, Paul TI Respiratory disease in army recruits - Surveillance program overview, 1995-2006 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID BENZATHINE PENICILLIN-G; STREPTOCOCCUS-PYOGENES; RHEUMATIC-FEVER; UNITED-STATES; INFLUENZA; PROPHYLAXIS; ADULTS; EPIDEMIOLOGY; INFECTIONS; PREVENTION AB Background: Since 1966, the U.S. Army has had in place a comprehensive surveillance system for acute respiratory disease (ARD) because of its continued high incidence in the recruit population. A retrospective review of the program from 1995 to 2006, a continuation of an earlier analysis from 1985-1994, was performed to describe the program and to summarize group A streptococcal (GAS) outbreaks identified through this program. Methods: Weekly incidence data and daily sentinel case data collected as part of the ARD surveillance program were analyzed in 2007 to report rates of ARD and GAS outbreaks over this 12-year period (1995-2006) for five participating Army sites. Results: Average ARD rates were consistently higher from 2000 to 2006 than from 1995 to 1999. Rate ratios of winter rates to summer rates were greater than 1.0 prior to 2000, but from 2000 to 2006, ratios were consistently near 1.0. Rheumatogenic M types were available for three of five outbreaks. Conclusions: Continuing high incidence of ARD in the military, re-emerging rheumatogenic M types, and a highly mobile military underscore the need for continued surveillance efforts. The continued employment of interventions with demonstrated effectiveness, such as chemoprophylaxis and basic preventive measures, is essential to reducing the burden of ARD. C1 [Lee, Seung-Eun; Eick, Angelia; Ciminera, Paul] USA, Ctr Hlth Promot & Prevent Med, Armed Forces Hlth Syrveillance Ctr Provis, Silver Spring, MD 20910 USA. RP Lee, SE (reprint author), USA, Ctr Hlth Promot & Prevent Med, Armed Forces Hlth Syrveillance Ctr Provis, 2900 Linden Lane,Suite 200, Silver Spring, MD 20910 USA. EM sekingeun.lee@us.army.mil NR 39 TC 3 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAY PY 2008 VL 34 IS 5 BP 389 EP 395 DI 10.1016/j.amepre.2007.12.027 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 299NE UT WOS:000255761500003 PM 18407005 ER PT J AU Haksworth, JS Brown, TS Leeser, DB Stojadinovic, A Tadaki, DK Cheng, O Mannon, RB Elster, EA AF Haksworth, Jason S. Brown, Trevor S. Leeser, David B. Stojadinovic, Alexander Tadaki, Doug K. Cheng, Orlena Mannon, Roz B. Elster, Eric A. TI Probabilistic (Bayesian) modeling of gene expression in transplant glomerulopathy SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT 8th American Transplant Congress CY MAY 31-JUN 04, 2008 CL Toronto, CANADA SP Amer Soc Transplant Surg, Amer Soc Transplantat C1 [Haksworth, Jason S.; Leeser, David B.; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Brown, Trevor S.; Tadaki, Doug K.; Elster, Eric A.] USN, Med Res Ctr, Silver Spring, MD USA. [Cheng, Orlena; Mannon, Roz B.] NIDDK, NIH, Bethesda, MD USA. [Elster, Eric A.] Natl Naval Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD MAY PY 2008 VL 8 SU 2 BP 275 EP 275 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA 299NV UT WOS:000255763200366 ER PT J AU Hurst, FP Neff, RT Falta, EM Parker, PM Agodoa, LY Abbott, KC AF Hurst, Frank P. Neff, Robert T. Falta, Edward M. Parker, Patrick M. Agodoa, Lawrence Y. Abbott, Kevin C. TI Incidence, predictors, and associated outcomes of benign prostatic hypertrophy after kidney transplantation. SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT 8th American Transplant Congress CY MAY 31-JUN 04, 2008 CL Toronto, CANADA SP Amer Soc Transplant Surg, Amer Soc Transplantat C1 [Hurst, Frank P.; Neff, Robert T.; Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Falta, Edward M.; Parker, Patrick M.] Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. [Agodoa, Lawrence Y.] NIDDK, NIH, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD MAY PY 2008 VL 8 SU 2 BP 450 EP 450 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA 299NV UT WOS:000255763201444 ER PT J AU Bell, RC Glen, AG AF Bell, Richard C., Jr. Glen, Andrew G. TI Experiences teaching probability and statistics with personal laptops in the classroom daily SO AMERICAN STATISTICIAN LA English DT Article DE EDF; laptop computer; statistical software AB What if every day of a probability and statistics class was a computer laboratory day? How would this change your method of teaching an introductory course in probability and statistics? At the United States Military Academy at West Point, wireless laptop computers have become a permanent part of the classroom and have changed our approach to teaching. Over the last five years, we have made a concerted effort to find the improvements technology has to offer and to steer clear of the pitfalls technology can bring to the classroom. Our method of teaching a calculus-based probability and statistics course has evolved into a data-oriented approach to understanding distributions. We present some methods we have developed that use spreadsheets and mathematical software systems to create an environment that helps students understand the foundations of probability theory and statistical inference. C1 [Bell, Richard C., Jr.; Glen, Andrew G.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Bell, RC (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM AA1275@usma.edu NR 7 TC 1 Z9 1 U1 0 U2 3 PU AMER STATISTICAL ASSOC PI ALEXANDRIA PA 1429 DUKE ST, ALEXANDRIA, VA 22314 USA SN 0003-1305 J9 AM STAT JI Am. Stat. PD MAY PY 2008 VL 62 IS 2 BP 155 EP 160 DI 10.1198/000313008X302091 PG 6 WC Statistics & Probability SC Mathematics GA 292IX UT WOS:000255260800012 ER PT J AU Nissan, A Peoples, GE Abu-Wasel, B Adair, CF Prus, D Howard, RS Lenington, SG Fields, SI Freund, HR Peretz, T Burch, HB Shriver, CD Stojadinovic, A AF Nissan, Aviram Peoples, George E. Abu-Wasel, Bassam Adair, Carol F. Prus, Diana Howard, Robin S. Lenington, Sarah G. Fields, Scott I. Freund, Herbert R. Peretz, Tamar Burch, Henry B. Shriver, Craig D. Stojadinovic, Alexander TI Prospective trial evaluating electrical impedance scanning of thyroid nodules before thyroidectomy - Final results SO ANNALS OF SURGERY LA English DT Article ID BREAST-CANCER; PREOPERATIVE EVALUATION; PREDICTING MALIGNANCY; LYMPH-NODES; YOUNG-WOMEN; ULTRASOUND; LESIONS; NEOPLASMS; DIAGNOSIS; RISK AB Background: Electrical impedance scanning (EIS) identifies tissue impedance changes associated with malignancy. Methods to distinguish benign from malignant thyroid nodules, particularly in patients with indeterminate cytology are lacking. Purpose: To determine the diagnostic accuracy of EIS in the preoperative evaluation of thyroid nodules. Patients and Methods: From September 2002 to December 2006, 216 patients underwent thyroid fine needle aspiration (FNA) and EIS prethyroidectomy in this prospective cohort study. EIS, either positive or negative for malignancy, was correlated with final histopathology. A focal bright spot over a thyroid nodule correlating with increased conductivity and/or capacitance > 25% baseline sternocleidomastoid muscle impedance defined positive EIS. Study endpoints were EIS accuracy, sensitivity (Sn), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV). This study has been registered in the National Institutes of Health's public trials registry at ClinicalTrials.gov. The registration number is NCT00571077. Results: EIS correctly diagnosed 96 of I 10 patients with malignant and 75 of 106 patients with benign dominant thyroid nodules: Sn = 87%, Sp = 71 %, PPV = 76%, NPV = 84%: overall EIS accuracy = 79%. Pretest cancer probability of 51 % (110 of 216) increased to 76% (96 of 127) post-EIS, and preoperative use of EIS would result in a significant reduction (71%, 75 of 106) in number of operations performed for benign nodules. EIS performance was similar for 109 patients with indeterminate FNA: Sn = 83%, Sp = 67%, PPV = 61 %, NPV = 87%, accuracy = 73%. Pretest probability of cancer increased from 39% (42 of 109) to 61% (35 of 57) post-EIS. The use of EIS would result in a significant reduction (67%, 45 of 67) in the number of purely diagnostic thyroidectomy for indeterminate FNA. Conclusion: EIS shows promise in differentiating thyroid nodules. Further EIS hardware and software optimization is warranted to improve upon the already favorable negative predictive value in indeterminate thyroid nodules. C1 [Nissan, Aviram; Abu-Wasel, Bassam; Freund, Herbert R.] Hadassah Hebrew Univ Med Ctr, Dept Surg, Jerusalem, Israel. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Shriver, Craig D.; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. [Adair, Carol F.] Baylor Univ, Med Ctr, Dept Pathol, Dallas, TX USA. [Prus, Diana] Hadassah Hebrew Univ Med Ctr, Dept Pathol, Jerusalem, Israel. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Div Biostat, Washington, DC 20307 USA. [Lenington, Sarah G.] SGL Biomed Consulting LLC, Ringwood, NJ USA. [Fields, Scott I.] Hadassah Hebrew Univ Med Ctr, Dept Radiol, Jerusalem, Israel. [Peretz, Tamar] Hadassah Hebrew Univ Med Ctr, Dept Oncol, Jerusalem, Israel. [Burch, Henry B.] Walter Reed Army Med Ctr, Dept Med, Serv Endocrinol, Washington, DC 20307 USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, 6900 Georgia Ave,Room 5C27A NW, Washington, DC 20307 USA. EM alexander.stojadinovic@na.amedd.army.mil NR 45 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD MAY PY 2008 VL 247 IS 5 BP 843 EP 853 DI 10.1097/SLA.0b013e318165c757 PG 11 WC Surgery SC Surgery GA 294RD UT WOS:000255422300018 PM 18438123 ER PT J AU Stojadinovic, A Nissan, A Protic, M Bilchik, AJ Peoples, GE AF Stojadinovic, Alexander Nissan, Aviram Protic, Mladjan Bilchik, Anton J. Peoples, George E. TI Alternative perspective on the rationale for lymphatic mapping for sentinel node identification in colon cancer - Reply SO ANNALS OF SURGERY LA English DT Letter ID PROSPECTIVE MULTICENTER TRIAL C1 [Stojadinovic, Alexander] US Mil Canc Inst, Walter Reed Army Med Ctr, Washington, DC USA. [Nissan, Aviram] Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel. [Protic, Mladjan] Clin Ctr Novi Sad, Inst Surg, Clin Abdominal & Endocrine Surg, Novi Sad, Serbia. [Bilchik, Anton J.] Univ Calif Los Angeles, Med Ctr, Los Angeles, CA 90024 USA. [Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Stojadinovic, A (reprint author), US Mil Canc Inst, Walter Reed Army Med Ctr, Washington, DC USA. EM alexander.stojadinovic@na.amedd.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD MAY PY 2008 VL 247 IS 5 BP 902 EP 904 DI 10.1097/SLA.0b013e31816ffb6a PG 3 WC Surgery SC Surgery GA 294RD UT WOS:000255422300028 ER PT J AU Rozak, DA Rozak, AJ AF Rozak, David A. Rozak, Anthony J. TI Simplicity, function, and legibility in an enhanced ambigraphic nucleic acid notation SO BIOTECHNIQUES LA English DT Article ID SEQUENCES AB Me previously showed that an ambigraphic nucleic acid notation, based on symmetrical lowercase Roman Characters, permits users to complement DNA by physically rotating the sequence text 180 degrees. This article describes an enhanced ambigraphic notation, which uses concept-related symbol design, rather than the arbitrary set of symbols that constitute the Roman alphabet, to logically em-ode the four DNA bases and II ambiguity characters. As ambigrams, the symbols continue to permit the rapid derivation of complementary sequences and visualization of palindromic DNA. In addition. the new AmbiScript notation uses legibility principles to support the identification of sequence polymorphism and improves writing efficiency by requiring fewer strokes per character than the International Union of Pure and Applied Chemistry (IUPAC) notation. C1 [Rozak, David A.] USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Rozak, Anthony J.] SUNY Buffalo, Coll Arts & Sci, Dept Visual Studies, Buffalo, NY 14260 USA. RP Rozak, DA (reprint author), USA, Bacteriol Div, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM david.rock@amedd.army.mil FU Ridee Institute for Science and Education FX This project was supported in part by an appointment to the Internship/Research Participation Program for the United States Army Medical Research and Materiel Command, administered by the Oak Ridee Institute for Science and Education through an agreement between the United States Department of Energy and the United States Army Medical Research and Materiel Command. The views of the authors do not purport to reflect the positions of the Department of the Army or the Department of Defense. NR 11 TC 1 Z9 1 U1 0 U2 1 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 0736-6205 J9 BIOTECHNIQUES JI Biotechniques PD MAY PY 2008 VL 44 IS 6 BP 811 EP 813 DI 10.2144/000112727 PG 3 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 411GQ UT WOS:000263637700016 PM 18476835 ER PT J AU Polson, J Wians, FH Orsulak, P Fuller, D Murray, NG Koff, JM Khan, AI Balko, JA Hynan, LS Lee, WM AF Polson, Julie Wians, Frank H., Jr. Orsulak, Paul Fuller, Dwain Murray, Natalie G. Koff, Jonathan M. Khan, Adil I. Balko, Jody A. Hynan, Linda S. Lee, William M. CA Acute Liver Failure Study Grp TI False positive acetaminophen concentrations in patients with liver injury SO CLINICA CHIMICA ACTA LA English DT Article DE acetaminophen toxicity; immunoassay; colorimetric assay; bilirubin AB Background: Acetaminophen toxicity is the most common form of acute liver failure in the U.S. After acetaminophen overdoses, quantitation of plasma acetaminophen can aid in predicting severity of injury. However, recent case reports have suggested that acetaminophen concentrations may be falsely increased in the presence of hyperbilirubinemia. Methods: We tested sera obtained from 43 patients with acute liver failure, mostly unrelated to acetaminophen, utilizing 6 different acetaminophen quantitation systems to determine the significance of this effect. In 36 of the 43 samples with bilirubin concentrations ranging from 1.0-61.5 mg/dl no acetaminophen was detectable by gas chromatography-mass spectroscopy. These 36 samples were then utilized to test the performance characteristics of 2 immunoassay and 4 enzymatic-colorimetric methods. Results: Three of four colorimetric methods demonstrated 'detectable' values for acetaminophen in from 4 to 27 of the 36 negative samples, low concentration positive values being observed when serum bilirubin concentrations exceeded 10 mg/dl. By contrast, the 2 immunoassay methods (EMIT, FPIA) were virtually unaffected. The false positive values obtained were, in general, proportional to the quantity of bilirubin in the sample. However, prepared samples of normal human serum with added bilirubin showed a dose-response curve for only one of the 4 colorimetric assays. Conclusions: False positive acetaminophen tests may result when enzymatic-colorimetric assays are used, most commonly with bilirubin concentrations >10 mg/dl, leading to potential clinical errors in this setting. Bilirubin (or possibly other substances in acute liver failure sera) appears to affect the reliable measurement of acetaminophen, particularly with enzymatic-colorimetric assays. (C) 2008 Published by Elsevier B.V. C1 [Polson, Julie; Lee, William M.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA. [Wians, Frank H., Jr.; Orsulak, Paul; Khan, Adil I.; Balko, Jody A.] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA. [Murray, Natalie G.] Baylor Univ, Med Ctr, Dallas, TX USA. [Murray, Natalie G.] Baylor All St Med Ctr, Ft Worth, TX USA. [Koff, Jonathan M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Hynan, Linda S.] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75390 USA. [Fuller, Dwain; Hynan, Linda S.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA. RP Lee, WM (reprint author), Univ Texas SW Med Ctr Dallas, Dept Internal Med Digest & Liver Dis, 5959 Harry Hines Blvd, Dallas, TX 75390 USA. EM William.Lee@UTSouthwestern.edu OI Hynan, Linda/0000-0002-4642-7769 FU NIDDK NIH HHS [U01 DK 58369, U01 DK058369] NR 9 TC 16 Z9 16 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-8981 J9 CLIN CHIM ACTA JI Clin. Chim. Acta PD MAY PY 2008 VL 391 IS 1-2 BP 24 EP 30 DI 10.1016/j.cca.2008.01.018 PG 7 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 300SR UT WOS:000255846000005 PM 18279672 ER PT J AU Revazishvili, T Rajanna, C Bakanidze, L Tsertsvadze, N Imnadze, P O'Connell, K Kreger, A Stine, OC Morris, JG Sulakvelidze, A AF Revazishvili, T. Rajanna, C. Bakanidze, L. Tsertsvadze, N. Imnadze, P. O'Connell, K. Kreger, A. Stine, O. C. Morris, J. G., Jr. Sulakvelidze, A. TI Characterisation of Yersinia pestis isolates from natural foci of plague in the Republic of Georgia, and their relationship to Y-pestis isolates from other countries SO CLINICAL MICROBIOLOGY AND INFECTION LA English DT Article; Proceedings Paper CT 107th General Meeting of the American-Society-for-Microbiology CY MAY 21-25, 2007 CL Toronto, CANADA SP Amer Soc Microbiol DE clonal relatedness; Georgia; multilocus sequence typing; pulsed-field gel electrophoresis; typing; Yersinia pestis ID GENOME SEQUENCE; PSEUDOTUBERCULOSIS; STRAINS; DNA; IDENTIFICATION; PIGMENTATION; DIVERSITY; REGIONS; LOCUS AB Forty Yersinia pestis isolates from endemic foci of plague in the Republic of Georgia, and six Y. pestis isolates from neighbouring former Soviet Union countries, were analysed for their biochemical and phenotypic properties, and their genetic relatedness was compared with Y. pestis strains KIM and CO92 by pulsed-field gel electrophoresis (PFGE). In addition, 11 Y. pestis isolates from the USA, together with published nucleotide sequences from Y. pestis strains KIM, CO92 and 91001, were compared with the 46 isolates in the present collection using multilocus sequence typing (MLST), based on sequence data for the 16S rRNA, hsp60, glnA, gyrB, recA, manB, thrA and tmk loci. Four virulence gene loci (caf1, lcrV, psaA and pla) were also sequenced and analysed. Two sequence types (ST1 and ST2), which differed by a single nucleotide, were identified by MLST. With the exception of a single isolate (771G), all of the Georgian Y. pestis isolates belonged to ST2. PFGE also grouped the Georgian Y. pestis isolates separately from the non-Georgian isolates. Overall, PFGE discriminated the Y. pestis isolates more effectively than MLST. The sequences of three of the four virulence genes (lcrV, psaA and pla) were identical in all Georgian and non-Georgian isolates, but the caf1 locus was represented by two allele types, with caf1 NT1 being associated with the non-Georgian isolates and caf1 NT2 being associated with the Georgian isolates. These results suggest that Georgian Y. pestis isolates are of clonal origin. C1 [Revazishvili, T.; Rajanna, C.; Morris, J. G., Jr.; Sulakvelidze, A.] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA. [Revazishvili, T.; Rajanna, C.; Morris, J. G., Jr.; Sulakvelidze, A.] Univ Florida, Coll Med, Emerging Pathogens Inst, Gainesville, FL 32610 USA. [Bakanidze, L.; Tsertsvadze, N.; Imnadze, P.] Minist Publ Hlth Georgia, Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [O'Connell, K.] USA, Edgewood Chem Biol Cgr, Aberdeen Proving Ground, MD USA. [O'Connell, K.; Kreger, A.; Stine, O. C.] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD USA. RP Sulakvelidze, A (reprint author), Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA. EM asulakvelidze@ufl.edu FU NIAID NIH HHS [1R21AI055660-01A1] NR 33 TC 11 Z9 15 U1 0 U2 5 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1198-743X J9 CLIN MICROBIOL INFEC JI Clin. Microbiol. Infect. PD MAY PY 2008 VL 14 IS 5 BP 429 EP 436 DI 10.1111/j.1469-0691.2008.01953.x PG 8 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 285PU UT WOS:000254789500004 PM 18294239 ER PT J AU Elster, EA Leeser, DB Morrissette, C Pepek, JM Quiko, A Hale, DA Chamberlain, C Salaita, C Kirk, AD Mannon, RB AF Elster, Eric A. Leeser, David B. Morrissette, Craig Pepek, Joseph M. Quiko, Albin Hale, Douglas A. Chamberlain, Christine Salaita, Christine Kirk, Allan D. Mannon, Roslyn B. TI Obesity following kidney transplantation and steroid avoidance immunosuppression SO CLINICAL TRANSPLANTATION LA English DT Article DE end-stage renal disease; immunosuppression; kidney transplantation; obesity; steroid avoidance ID RENAL-TRANSPLANTATION; WEIGHT-GAIN; RISK-FACTOR; DISEASE; MONOTHERAPY; RECIPIENTS; INDUCTION; THERAPY AB Obesity is an important co-morbidity within end-stage renal disease (ESRD) and renal transplant populations. Previous studies have suggested that chronic corticosteroids result in increased body weight post-transplant. With the recent adoption of steroid-sparing immunosuppressive strategies, we evaluated the effect of these strategies on body mass index (BMI) after renal transplantation. We examined 95 renal transplant recipients enrolled in National Institutes of Health clinical transplant trials over the past three yr who received either lymphocyte depletion-based steroid sparing or traditional immunosuppressive therapy that included steroids for maintenance immunosuppression. Recipients were overweight prior to transplant and no significant differences existed in pre-transplant BMI among treatment groups. Regardless of therapy, BMI increased post-transplant in all recipients. The BMI increase consisted of an average weight gain of 5.01 +/- 7.12 kg (mean, SD) post-transplant. Additionally, in a number of recipients placed on maintenance steroids, subsequent withdrawal at a mean of 100 d post-transplant had no impact on weight gain. Thus, body weight and BMI increase following kidney transplantation, even in the absence of steroids. Thus, patients gain weight after renal transplantation regardless of the treatment strategy. Steroid avoidance alone does not reduce risk factors associated with obesity in our patient population. C1 [Elster, Eric A.; Leeser, David B.; Hale, Douglas A.; Chamberlain, Christine; Salaita, Christine; Kirk, Allan D.; Mannon, Roslyn B.] NIDDKD, Transplantat Branch, NIH, Bethesda, MD 20892 USA. [Elster, Eric A.; Pepek, Joseph M.] USN, Naval Med Res Ctr, Combat Casualty Care Directorate, Silver Spring, MD USA. [Elster, Eric A.; Leeser, David B.; Hale, Douglas A.; Kirk, Allan D.] USA, Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20310 USA. [Elster, Eric A.; Leeser, David B.; Quiko, Albin] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Elster, Eric A.] USN, Natl Naval Med Ctr, Dept Surg, Bethesda, MD 20084 USA. [Morrissette, Craig] USA, Walter Reed Army Inst Res, Silver Spring, MD USA. RP Elster, EA (reprint author), 503Robert Grant Ave, Silver Spring, MD USA. EM eric.elster@med.navy.mil RI Kirk, Allan/B-6905-2012 NR 16 TC 20 Z9 20 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0902-0063 J9 CLIN TRANSPLANT JI Clin. Transplant. PD MAY-JUN PY 2008 VL 22 IS 3 BP 354 EP 359 DI 10.1111/j.1399-0012.2008.00792.x PG 6 WC Surgery; Transplantation SC Surgery; Transplantation GA 301OX UT WOS:000255906600012 PM 18279417 ER PT J AU Neta, B Johnson, AN AF Neta, B. Johnson, Anthony N. TI High-order nonlinear solver for multiple roots SO COMPUTERS & MATHEMATICS WITH APPLICATIONS LA English DT Article DE nonlinear equations; high order; multiple roots; fixed point ID ITERATIVE METHODS; EQUATIONS; FAMILY AB A method of order four for finding Multiple zeros of nonlinear functions is developed. The method is based on Jarratt's fifth-order method (for simple roots) and it requires one evaluation of the function and three evaluations of the derivative. The informational efficiency of the method is the same as previously developed schemes of lower order. For the special case of double root, we found a family of fourth-order methods requiring one less derivative. Thus this family is more efficient than all others. All these methods require the knowledge of the multiplicity. Published by Elsevier Ltd. C1 [Neta, B.] USN, Postgrad Sch, Dept Appl Math, Monterey, CA 93943 USA. [Johnson, Anthony N.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Neta, B (reprint author), USN, Postgrad Sch, Dept Appl Math, Monterey, CA 93943 USA. EM byneta@gmail.com RI Neta, Beny/B-1737-2009 NR 13 TC 46 Z9 46 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0898-1221 J9 COMPUT MATH APPL JI Comput. Math. Appl. PD MAY PY 2008 VL 55 IS 9 BP 2012 EP 2017 DI 10.1016/j.camwa.2007.09.001 PG 6 WC Mathematics, Applied SC Mathematics GA 293IH UT WOS:000255328500010 ER PT J AU Yeh, S Colyer, MH Weichel, ED AF Yeh, Steven Colyer, Marcus H. Weichel, Eric D. TI Current trends in the management of intraocular foreign bodies SO CURRENT OPINION IN OPHTHALMOLOGY LA English DT Article DE delayed foreign body removal; intraocular foreign body (IOFB) open globe injury; pars plana vitrectomy; posttraumatic endophthalmitis ID PENETRATING OCULAR TRAUMA; PARS-PLANA VITRECTOMY; POSTERIOR SEGMENT; PROGNOSTIC-FACTORS; LENS IMPLANTATION; BODY REMOVAL; SURGICAL-MANAGEMENT; IRAQI FREEDOM; EYE INJURY; ENDOPHTHALMITIS AB Purpose of review The aim of this article is to present the recent literature on the preoperative assessment, intraoperative management and postoperative care of patients with intraocular foreign bodies and present a management algorithm. Recent findings The preoperative assessment includes an evaluation of concomitant, potentially life-threatening conditions, as well as a relevant history and ophthalmic examination. Neuroimaging, preferably with noncontrast helical computed tomography, provides excellent information about intraocular foreign body size, shape and location. The preoperative assessment provides valuable information for prognosis, counseling, and intraoperative guidance. The decision of delayed versus immediate intraocular foreign body removal must be guided by the patient's medical status, availability of adequate operating facilities and staff, and the presence of clinical endophthalmitis. The administration of perioperative systemic and topical third or fourth-generation fluoroquinolones may play a role in decreasing the incidence of postoperative endophthalmitis. Intravitreal antibiotics warrant consideration in patients with a Gram stain positive for organisms, in cases suspicious for endophthalmitis, and in high-risk settings. Both the material and size of the foreign body are considerations in the choice of instrument and extraction site used (sclerotomy versus scleral tunnel) at time of pars plana vitrectomy and intraocular foreign body removal. Postoperatively, patients should be monitored closely for the development of endophthalmitis, retinal detachment and proliferative vitreoretinopathy. Summary This review summarizes the recent literature on the assessment of intraocular foreign bodies and techniques for their removal. An algorithm provides guidelines for their perioperative and operative management. C1 [Colyer, Marcus H.; Weichel, Eric D.] Walter Reed Army Med Ctr, Ophthalmol Serv, Dept Surg, Washington, DC 20307 USA. [Yeh, Steven; Weichel, Eric D.] NEI, NIH, Washington, DC USA. RP Weichel, ED (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, Dept Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM weichele@nei.nih.gov NR 61 TC 41 Z9 45 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-8738 J9 CURR OPIN OPHTHALMOL JI Curr. Opin. Ophthalmol. PD MAY PY 2008 VL 19 IS 3 BP 225 EP 233 DI 10.1097/ICU.0b013e3282fa75f1 PG 9 WC Ophthalmology SC Ophthalmology GA 296MG UT WOS:000255548100010 PM 18408498 ER PT J AU Sims, JG Steevens, JA AF Sims, Jerre G. Steevens, Jeffery A. TI The role of metabolism in the toxicity of 2,4,6-trinitrotoluene and its degradation products to the aquatic amphipod Hyalella azteca SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE TNT; 2-ADNT; 4-ADNT; 2, 4-DANT; 1, 3, 5-TNB; metabolism; bioaccumulation; beta-napthoflavone; clotrimazole; Hyalella azteca ID COVALENT BINDING; DAPHNIA-MAGNA; TRINITROTOLUENE; TNT; CYTOTOXICITY; CLOTRIMAZOLE; MUTAGENICITY; INHIBITION; RAT AB Toxicological data on the effects of the explosive, 2,4,6-trinitrotoluene (TNT), and its degradation products suggests an unpredictable toxicological response in aquatic organisms. Several studies suggest TNT becomes more toxic as it degrades while others suggest TNT becomes less toxic. This study focused on the toxicity of TNT and several degradation products as well as the role of oxidative metabolism in the toxicity of TNT. The aquatic invertebrate Hyalella azteca was used to evaluate the toxicity of TNT and four of its degradation products. The most reduced degradation product, 2,4-diamino, 6-nitrotoluene (2,4-DANT) was the most toxic to H. azteca. However, 2,4-DANT was only a minor metabolite in H. azteca. The influence of metabolism on the toxicokinetics of TNT was assessed indirectly through the use of a CYP450 inducer and inhibitor. Treatment of organisms with beta-napthoflavone (BNF), a CYP450 inducer, increased the toxicity of TNT and increased the rate of elimination and metabolism of TNT. Similar to BNF, organisms treated with clotrimazole (CTZ), a CYP450 inhibitor, resulted in increased toxicity and TNT metabolism. It is likely the ability to metabolize or bioactivate TNT to a more reactive intermediate plays a significant role in the sensitivity of organisms to TNT. (C) 2007 Elsevier Inc. All rights reserved. C1 [Sims, Jerre G.; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Sims, JG (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jerre.g.sims@erdc.usace.army.mil NR 34 TC 10 Z9 10 U1 2 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 EI 1090-2414 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD MAY PY 2008 VL 70 IS 1 BP 38 EP 46 DI 10.1016/j.ecoenv.2007.08.019 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 305WC UT WOS:000256207500005 PM 17980428 ER PT J AU Hartstein, BH Barry, JD AF Hartstein, B. H. Barry, J. D. TI Mitigation of pain during intravenous catheter placement using a topical skin coolant in the emergency department SO EMERGENCY MEDICINE JOURNAL LA English DT Article ID ETHYL CHLORIDE; INTRADERMAL LIDOCAINE; VENOUS CANNULATION; VENIPUNCTURE; EMLA; CREAM; INFILTRATION; LIGNOCAINE; INJECTION; ADULTS AB Objective: Although intravenous (IV) line placement is a common procedure in the emergency department (ED), it is an uncomfortable experience for many patients. Topical analgesic agents are rarely used because they have long onsets of action and thereby cause unacceptable treatment delays. Cryoanaesthesia, the use of cooling agents to reduce pain, has been recognised for many years as a potential pain management strategy. The purpose of this study was to determine whether an instantaneous topical skin coolant spray reduces patient's pain during IV cannulation and represents a feasible alternative for cutaneous analgesia in the ED setting. Methods: We conducted an unblinded, randomised, controlled study, in a convenience sample of ED patients. Utilising a random number generator to assign patients to the control or study group, patients over the age of 18 years who required IV cannulation as part of their evaluation were enrolled at two tertiary care hospitals. In both groups, IV lines were placed in accordance with accepted clinical standards of practice, with the single addition of the coolant spray delivered to the IV site before needle insertion in the study group. All study participants answered questionnaires before and after IV placement and rated pain during procedure on a 100 mm visual analogue scale. Results: Of the 92 patients enrolled in the study, 47 (51.1%) were randomised to the study group and received the anaesthetic spray, and 45 (48.9%) were randomised to the control group and had their IV placed in a standard method. 66 patients were female (71.8%) and 26 (28.2%) were males. The mean pain score in the study group was 27 mm (95% confidence interval (CI) 19.9 to 34.1 mm) and 28 mm (95% CI 20.4 to 35.6 m) in the control group (p = 0.934). Subgroup analysis of female and male patients did not show significance. Conclusions: Our study failed to detect a difference in pain perception resulting from the pre-procedural application of a skin coolant associated with IV placement in the ED setting. C1 [Hartstein, B. H.; Barry, J. D.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. RP Barry, JD (reprint author), Brooke Army Med Ctr Attn MCHE EM, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM james.barry@amedd.army.mil NR 11 TC 17 Z9 17 U1 0 U2 5 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1472-0205 J9 EMERG MED J JI Emerg. Med. J. PD MAY PY 2008 VL 25 IS 5 BP 257 EP 261 DI 10.1136/emj.2006.044776 PG 5 WC Emergency Medicine SC Emergency Medicine GA 292UD UT WOS:000255290700004 PM 18434455 ER PT J AU Naumann, JC Young, DR Anderson, JE AF Naumann, Julie C. Young, Donald R. Anderson, John E. TI Leaf chlorophyll fluorescence, reflectance, and physiological response to freshwater and saltwater flooding in the evergreen shrub, Myrica cerifera SO ENVIRONMENTAL AND EXPERIMENTAL BOTANY LA English DT Article DE chlorophyll fluorescence; flooding; salinity; physiological reflectance index; photosynthesis; water relations; stress; Myrica ID RADIATION-USE-EFFICIENCY; XANTHOPHYLL CYCLE; PHOTOSYSTEM-II; BARRIER-ISLAND; STEADY-STATE; ENERGY-DISSIPATION; STOMATAL CONDUCTANCE; SPECTRAL REFLECTANCE; PHOTON YIELD; C-3 PLANTS AB Photosynthesis, water relations, chlorophyll fluorescence, and leaf reflectance were used to evaluate stress due to freshwater and saltwater flooding in the evergreen coastal shrub, Myrica cerifera, under controlled conditions. M. cerifera forms large monospecific thickets that facilitate scaling up from leaf-level measurements to the landscape. Based on physiological responses, stress began by day 3 in flooded plants treated with 5, 10, and 15 g L-1 salinity, as seen by significant decreases in stomatal conductance and net photosynthesis relative to control plants. Decreases in physiological measurements occurred by day 9 in freshwater flooded plants. Visible signs of stress occurred by day 5 for plants treated with 15 gL(-1), day 8 for flooded plants exposed to 10 gL(-1), and day 10 for those treated with 5 gL(-1) salinity. Significant differences in light-adapted fluorescence yield (Delta F/F-m') were observed by day 3 in plants flooded with 5, 10, and 15 gL(-1) salinity and day 6 in freshwater flooded plants. Non-photochemical quenching (Phi(NPQ)) increased with decreasing Delta F/F-m'. In comparison, statistical differences in dark-adapted fluorescence yield (F-v/F-m) were observed by day 12 in plants flooded with 5, 10, and 15 g L-1 salinity, well after visible signs of stress were apparent. Fluorescence parameters were successful at detecting and distinguishing both freshwater and saltwater flooding stress. A positive, linear correlation (r(2) = 0.80) was observed between Delta F/F-m' and the physiological reflectance index (PRI). Xanthophyll-cycle dependent energy dissipation appears to be the underlying mechanism in protecting photosystem II from excess energy in saltwater flooded plants. Delta F/F-m' was useful in detecting stress-induced changes in the photosystem before any visible signs of damage were evident at the leaf-level. This parameter may be linked to hyperspectral reflectance data for rapid detection of stress at the canopy-level. (C) 2008 Elsevier B.V. All rights reserved. C1 [Naumann, Julie C.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. [Anderson, John E.] USA, ERDC, Fluorescence Spect Lab, Alexandria, VA 22315 USA. RP Young, DR (reprint author), Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. EM dryoung@vcu.edu NR 50 TC 57 Z9 66 U1 0 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0098-8472 J9 ENVIRON EXP BOT JI Environ. Exp. Bot. PD MAY PY 2008 VL 63 IS 1-3 BP 402 EP 409 DI 10.1016/j.envexpbot.2007.12.008 PG 8 WC Plant Sciences; Environmental Sciences SC Plant Sciences; Environmental Sciences & Ecology GA 283YF UT WOS:000254671700045 ER PT J AU Kaunda, RB Chase, RB Kehew, AE Kaugars, K Selegean, JP AF Kaunda, Rennie B. Chase, Ronald B. Kehew, Alan E. Kaugars, Karlis Selegean, James P. TI Interpretation of a progressive slope movement using balanced cross sections and numerical integration SO ENVIRONMENTAL & ENGINEERING GEOSCIENCE LA English DT Article DE geotechnical; Gaussian quadrature; structure; landslides; modeling; soil mechanics ID FAILURE AB Gaussian quadrature, a numerical integration technique through fixed points, is applied to improve accuracy and efficiency in the cross-section balance modeling of a slope subjected to progressive displacements. This integration is employed to compute geometrical areas of individual stratigraphic units that have participated in the deformation. Given the initial and final states of a natural slope in which progressive failure has been carefully monitored for 7 years, the internal geometry of four stratigraphic layers that were displaced in a manner that characterizes the displacement kinematics of the entire slope has been analyzed. The area differences between the initial and final sections for three of the layers are zero. A fourth, basal, layer shows a unit area reduction of 13 percent, which can be accounted for by toe erosion. This implies that the total internal geometric area is found to be preserved during the course of the progressive deformation, a fact that is evident in repeated ground surveys conducted during the 7-year history of displacement. Also, factors of safety computed for the basal surface of slip at the initial and final stages of displacement monitoring demonstrate that the slope became less stable over a period of 7 years as a result of the progressive failure. Such a reduction in stability would be difficult to quantify without the application of numerical integration that allows the accurate construction of area-balanced geometrical models in a digital format amenable to validation and stability analysis. C1 [Kaunda, Rennie B.; Chase, Ronald B.; Kehew, Alan E.] Western Michigan Univ, Dept Geosci, Kalamazoo, MI 49008 USA. [Kaugars, Karlis] Western Michigan Univ, Dept Comp Sci, Kalamazoo, MI 49008 USA. [Selegean, James P.] USA, Corps Engineers, Great Lakes Hydraul & Hydrol Off, Detroit, MI 48226 USA. RP Kaunda, RB (reprint author), Western Michigan Univ, Dept Geosci, Kalamazoo, MI 49008 USA. NR 19 TC 2 Z9 2 U1 1 U2 6 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1078-7275 J9 ENVIRON ENG GEOSCI JI Environ. Eng. Geosci. PD MAY PY 2008 VL 14 IS 2 BP 121 EP 131 DI 10.2113/gseegeosci.14.2.121 PG 11 WC Engineering, Environmental; Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 333DI UT WOS:000258132000005 ER PT J AU McDonald, KW AF McDonald, Kenneth W. TI Soil response model verification: A multi-year study of foot traffic impact SO ENVIRONMENTAL IMPACT ASSESSMENT REVIEW LA English DT Article DE soil compaction; math modeling verification; bulk density; foot traffic; military training; west point ID VEGETATION AB The purpose of this research is to build upon the baseline study of soil compaction response to trampling previously conducted. Although trampling studies have been conducted in the past, the analysis of military training, in part, provides a different perspective and approach. The baseline data showed bulk densities remained relatively constant for a time and then began to increase at an increasing rate for several hundred passes and finally leveled and remained at or below 1.30 gm/cm (3) through the remainder of the experiment. A mathematical model was created based on empirical data from the trampling experiment using a gamma cumulative distribution function. Subsequent similar experiments were conducted over the following 2 years to verify the baseline model soil response. The follow-on data were modeled using the same gamma distribution function with good results. The model replicated the soil response for the subsequent years well with the exception of the initial threshold which was dramatically reduced for both years. The experiments and the resulting model give quantifiable continuous inference on the effects of trampling, as opposed to the existing qualitative assessments. This model performed well and can be used as a foundation for future studies of land management when trampling occurs. (c) 2007 Elsevier Inc. All rights reserved. C1 [McDonald, Kenneth W.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP McDonald, KW (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM kenneth.mcdonald@usace.army.mil NR 21 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0195-9255 J9 ENVIRON IMPACT ASSES JI Environ. Impact Assess. Rev. PD MAY-JUN PY 2008 VL 28 IS 4-5 BP 321 EP 327 DI 10.1016/j.eiar.2007.10.004 PG 7 WC Environmental Studies SC Environmental Sciences & Ecology GA 296XN UT WOS:000255579300007 ER PT J AU Dickson, TL Wilsey, BJ Busby, RR Gebhart, DL AF Dickson, Timothy L. Wilsey, Brian J. Busby, Ryan R. Gebhart, Dick L. TI Grassland plant composition alters vehicular disturbance effects in Kansas, USA SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE vegetation change; species composition; catastrophic shift; military lands ID LONG-TERM DISTURBANCE; VEHICLE IMPACTS; MILITARY MANEUVERS; LAND-USE; VEGETATION; MANAGEMENT; PRODUCTIVITY; WASHINGTON; DYNAMICS; ECOLOGY AB Many "natural" areas are exposed to military or recreational off-road vehicles. The interactive effects of different types of vehicular disturbance on vegetation have rarely been examined, and it has been proposed that some vegetation types are less susceptible to vehicular disturbance than others. At Fort Riley, Kansas, we experimentally tested how different plant community types changed after disturbance from an M1A1 Abrams tank driven at different speeds and turning angles during different seasons. The greatest vegetation change was observed because of driving in the spring in wet soils and the interaction of turning while driving fast (vegetation change was measured with Bray-Curtis dissimilarity). We found that less vegetation change occurred in communities with high amounts of native prairie vegetation than in communities with high amounts of introduced C-3 grasses, which is the first experimental evidence we are aware of that suggests plant communities dominated by introduced C-3 grasses changed more because of vehicular disturbance than communities dominated by native prairie grasses. We also found that vegetation changed linearly with vehicular disturbance intensity, suggesting that at least initially there was no catastrophic shift in vegetation beyond a certain disturbance intensity threshold. Overall, the intensity of vehicular disturbance appeared to play the greatest role in vegetation change, but the plant community type also played a strong role and this should be considered in land use planning. The reasons for greater vegetation change in introduced C-3 grass dominated areas deserve further study. C1 [Dickson, Timothy L.; Wilsey, Brian J.] Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA 50011 USA. [Busby, Ryan R.; Gebhart, Dick L.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Dickson, TL (reprint author), Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA 50011 USA. EM dicksont@iastate.edu OI Wilsey, Brian J./0000-0002-0628-5006 NR 51 TC 8 Z9 8 U1 1 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD MAY PY 2008 VL 41 IS 5 BP 676 EP 684 DI 10.1007/s00267-007-9064-4 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 290HF UT WOS:000255113200005 PM 18204985 ER PT J AU Mcfarland, CA Quinn, MJ Bazar, MA Remick, AK Talent, LG Johnson, MS AF Mcfarland, Craig A. Quinn, Michael J., Jr. Bazar, Matthew A. Remick, Amera K. Talent, Larry G. Johnson, Mark S. TI Toxicity of oral exposure to 2,4,6-trinitrotoluene in the western fence lizard (Sceloporus occidentalis) SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE reptiles; explosives; trinitrotoluene; toxicity; lizard ID DOSE-RESPONSE; TNT EXPOSURE; DNA-DAMAGE; TRINITROTOLUENE; RATS; DOGS AB Contamination of the soil with the explosive 2,4,6-trinitrotoluene (TNT) has been found at military sites, many of which are habitats used by reptiles. To provide data useful in assessing ecological risk for reptilian species, acute, subacute, and subchronic oral toxicity studies were conducted with the western fence lizard (Sceloporus occidentalis). Oral median lethal dose (LD50) values for TNT in corn oil were 1,038 and 1,579 mg/kg of body weight for male and female lizards, respectively. Overt signs of toxicity included chromaturia, abdominal enlargement, and tremors. A 14-d subacute study followed in which male lizards were orally dosed with TNT (corn oil) at 0, 33, 66, 132, 263, 525, and 1,050 mg/kg of body weight each day. Clinical signs of toxicity, while similar to the LD50 study, were more subtle and noted in lizards receiving TNT amounts of at least 66 mg/kg/d. Chromaturia was an early consistent sign, often preceding the onset of adverse effects. Male lizards in the 60-d subchronic study were dosed at 0, 3, 15, 25, 35, and 45 mg/kg/d with nearly complete survival (>90%) for lizards in all treatments. Changes in food consumption and body weight were observed at 35 and 45 mg/kg/d. Alterations in hematological end points; blood chemistries (albumin, total protein, alkaline phosphatase, calcium); kidney, spleen, and liver weights; and adverse histopathology were observed in lizards exposed at 25 to 45 mg/kg/d. Testosterone concentration, sperm count, and motility were variable between treatments. Although not significant, incidences of hypospermia and testicular atrophy were observed in some individuals. Together, these data suggest a lowest-observed-adverse effect level of 25 mg/kg/d and a no-observed-adverse effect level of 15 mg/kg/d in S. occidentalis. C1 [Mcfarland, Craig A.; Quinn, Michael J., Jr.; Bazar, Matthew A.; Johnson, Mark S.] USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, ATTN MCHB TS THE, Aberdeen Proving Ground, MD 21010 USA. [Remick, Amera K.] Biotech LLc, Hillsborough, NC 27278 USA. [Talent, Larry G.] Oklahoma State Univ, Stillwater, OK 74078 USA. RP Mcfarland, CA (reprint author), USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, ATTN MCHB TS THE, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM craig.a.mcfarland@us.army.mil NR 36 TC 16 Z9 18 U1 0 U2 5 PU SOC ENVIRONMENTAL TOXICOLOGY & CHEMISTRY-SETAC PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAY PY 2008 VL 27 IS 5 BP 1102 EP 1111 DI 10.1897/07-312.1 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 289OL UT WOS:000255063700012 PM 18419183 ER PT J AU Foglia, G Sateren, WB Renzullo, PO Bautista, CT Langat, L Wasunna, MK Singer, DE Scott, PT Robb, ML Birx, DL AF Foglia, G. Sateren, W. B. Renzullo, P. O. Bautista, C. T. Langat, L. Wasunna, M. K. Singer, D. E. Scott, P. T. Robb, M. L. Birx, D. L. TI High prevalence of HIV infection among rural tea plantation residents in Kericho, Kenya SO EPIDEMIOLOGY AND INFECTION LA English DT Article ID SUB-SAHARAN AFRICA; MALE CIRCUMCISION; VACCINE TRIALS; RISK; MEN; ACCEPTABILITY; FEASIBILITY AB Human immunodeficiency virus type 1 (HIV-1) epidemiology among residents of a rural agricultural plantation in Kericho, Kenya was studied. HIV-1 prevalence was 14 center dot 3%, and was higher among, women (19 center dot 1%) than men (11 center dot 3%). Risk factors associated with HIV-1 for men were age (>= 25 years), marital history (one or more marriages), age difference from current spouse (>= 5 years), Luo ethnicity, sexually transmitted infection (STI) symptomis In the past 6 months. circumcision (protective). and sexual activity (>= 7 years). Among women. risk factors associated with HIV-1 were age (25-29 years. >= 35 years), marital history (one or more marriages), age difference from current spouse (>= 10 years). Luo ethnicity, STI symptoms in the past 6 months, and a STI history in the past 5 years. Most participants (96%) expressed a willingness to participate in a future HIV vaccine study. These findings will facilitate targeted intervention and prevention measures for HIV-1 infection in Kericho. C1 [Sateren, W. B.; Singer, D. E.; Scott, P. T.; Birx, D. L.] Walter Reed Army Med Ctr, Div Retrovirol, Rockville, MD 20850 USA. [Foglia, G.; Langat, L.] USA, Med Res Unit, Nairobi, Kenya. [Renzullo, P. O.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Bautista, C. T.; Robb, M. L.] Henry M Jackson Fdn Advancement Mil Med Inc, US Mil HIV Res Program, Rockville, MD USA. [Wasunna, M. K.] Kenya Govt Med Res Ctr, Nairobi, Kenya. RP Sateren, WB (reprint author), Walter Reed Army Med Ctr, Div Retrovirol, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. EM WSateren@hivresearch.org RI Bautista, Christian/B-2812-2011 FU Walter Reed Army Institute of Research; Kenya Medical Research Institute, Nairobi, Kenya FX This study was supported and approved by the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research (WRAIR protocol #855, RV142), and by the Kenya Medical Research Institute, Nairobi, Kenya. The material has been reviewed by the Walter Reed Army Institute of Research and there is no objection to its presentation and/or publication. The authors Would like to thank the management and employees of James K. Finlay LLC (formerly African Highlands Produce) for their invaluable assistance and cooperation during the conduct of this research among plantation emloyees and their dependants. We thank Dr Nelson L. Michael at the Walter Reed Army Institute of Research For manuscript review. NR 24 TC 12 Z9 12 U1 1 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD MAY PY 2008 VL 136 IS 5 BP 694 EP 702 DI 10.1017/S0950268807009028 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 348GG UT WOS:000259198400013 PM 17599780 ER PT J AU Swenson, DL Warfield, KL Larsen, T Alves, DA Coberley, SS Bavari, S AF Swenson, Dana L. Warfield, Kelly L. Larsen, Tom Alves, D. Anthony Coberley, Sadie S. Bavari, Sina TI Monovalent virus-like particle vaccine protects guinea pigs and nonhuman primates against infection with multiple Marburg viruses SO EXPERT REVIEW OF VACCINES LA English DT Article DE antibody; Ebola; filovirus; Marburg; nonhuman primate; protective immunity; vaccine; virus-like particle ID ATTENUATED RECOMBINANT VACCINE; FILOVIRUS-LIKE PARTICLES; EBOLA-VIRUS; MONKEYS; LETHAL; DISEASE; GLYCOPROTEIN; PATHOGENESIS; INDUCTION; RESPONSES AB Background: Virus-like particle (VLP)-based vaccines have the advantage of being morphologically and antigenically similar to the live virus from which they are derived, Expression of the glycoprotein and VP40 matrix protein from Lake Victoria marburgvirus (MARV) results in spontaneous production of VLPs in mammalian cells. Guinea pigs vaccinated with Marburg virus VLPs (mVLPs) or inactivated MARV (iMARV) develop homologous humoral and T-cell responses and are completely protected from a lethal homologous MARV challenge. Aims & methods: To determine whether mVLPs based on the Musoke (aka Lake Victoria) isolate of MARV could broadly protect against diverse isolates of MARV guinea pigs were vaccinated with mVLPs or iMARV-Musoke and challenged with MARV-Musoke, -Ravn or Ci67. Results: Prior to challenge, the mVLP- and iMARV-vaccinated guinea pigs had high levels of homologous MARV-Musoke and heterologous MARV-Ravn and -Ci67 antibodies. The Musoke-based mVLPs and iMARV vaccines provided complete protection in guinea pigs against viremia, viral replication and pathological changes in tissues, and lethal disease following challenge with MARV-Musoke, -Ravn or -Ci67. Guinea pigs vaccinated with RIBI adjuvant alone and infected with guinea pig-adapted MARV-Musoke, -Ravn or -Ci67 had histopathologic findings similar to those seen in the nonhuman primate model for MARV infection. Based on the strong protection observed in guinea pigs, we next vaccinated cynomolgus macaques with Musoke-based mVLPs and showed the VLP-vaccinated monkeys were broadly protected against three isolates of MARV (Musoke, Ravn and Ci67). Conclusion: Musoke mVLPs are effective at inducing broad heterologous immunity and protection against multiple MARV isolates. C1 [Swenson, Dana L.; Warfield, Kelly L.; Larsen, Tom; Alves, D. Anthony; Coberley, Sadie S.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM dana.swenson@us.army.mil; kelly.warfield@us.army.mil; thomas.larsen@covance.com; derron.alves@amedd.army.mil; coberleys@nbacc.net; sina.bavari@us.army.mil NR 40 TC 39 Z9 41 U1 0 U2 0 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD MAY PY 2008 VL 7 IS 4 BP 417 EP 429 DI 10.1586/14760584.7.4.417 PG 13 WC Immunology SC Immunology GA 343EU UT WOS:000258836500011 PM 18444889 ER PT J AU Frattarelli, JL McWilliams, GDE Hill, MJ Miller, KA Scott, RT AF Frattarelli, John L. McWilliams, Grant D. E. Hill, Micah J. Miller, Kathleen A. Scott, Richard T., Jr. TI Low-dose aspirin use does not improve in vitro fertilization outcomes in poor responders SO FERTILITY AND STERILITY LA English DT Article DE diminished ovarian reserve; poor responders; IVF outcomes; low-dose aspirin; pregnancy; live birth; ovarian response ID PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; OVARIAN RESPONSIVENESS; PREGNANCY RATES; WOMEN; IMPLANTATION; ANTIBODIES; THERAPY; HEPARIN; STIMULATION AB Objective: To assess if aspirin improves pregnancy outcome in patients undergoing in vitro fertilization (IVF) with a diagnosis of poor response. Design: Retrospective cohort analysis. Setting: Academic private practice. Patient(s): 1250 poor-responder patients undergoing IVF. Intervention(S): Low-dose (81 mg) aspirin before and during an IVF cycle. Main Outcome Measure(S): Live-birth rate. Result(s): Patients taking 81 mg of aspirin had statistically significantly higher basal antral follicle counts, more days of stimulation, more ampules of gonadotropins used, higher peak estradiol levels, and more follicles that were >= 14 mm in diameter on the day of human chorionic gonadotropin administration. There was a decrease in the overall fertilization rate for the patients taking aspirin. There was no difference in IVF outcome rates (implantation, pregnancy, loss, or live birth). Conclusion(s): Patients with a diagnosis of poor response who were taking a regimen of 81 of mg aspirin showed an increase in many IVF stimulation parameters and a decrease in fertilization rates. No improvement secondary to 81-mg aspirin intake was found in IVF outcome rates. C1 [Frattarelli, John L.; Miller, Kathleen A.; Scott, Richard T., Jr.] Reprod Med Associates New Jersey, Morristown, NJ USA. [McWilliams, Grant D. E.; Hill, Micah J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Frattarelli, JL (reprint author), Reprod Med Associates New Jersey, 100 Franklin Sq Dr,Suite 200, Somerset, NJ 08873 USA. EM jfrattarelli@rmanj.com RI Hill, Micah/A-6777-2009 NR 23 TC 20 Z9 21 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD MAY PY 2008 VL 89 IS 5 BP 1113 EP 1117 DI 10.1016/j.fertnstert.2007.05.007 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 303XY UT WOS:000256075700013 PM 17612539 ER PT J AU Frattarelli, JL Hill, MJ McWilliams, GDE Miller, KA Bergh, PA Scott, RT AF Frattarelli, John L. Hill, Micah J. McWilliams, Grant D. E. Miller, Kathleen A. Bergh, Paul A. Scott, Richard T., Jr. TI A luteal estradiol protocol for expected poor-responders improves embryo number and quality SO FERTILITY AND STERILITY LA English DT Article DE poor responders; IVF outcome; luteal phase; estradiol; embryo morphology; oocytes; pregnancy; ovarian responsiveness; follicular pool ID IN-VITRO FERTILIZATION; CONTROLLED OVARIAN HYPERSTIMULATION; ANTRAL FOLLICLES; STIMULATION; GROWTH; CYCLES; MANAGEMENT; ANTAGONIST; FLARE; IVF AB Objective: To compare embryo and oocyte data between a standard protocol and a luteal phase estradiol protocol. Design: Retrospective paired cohort analysis. Setting: Private in vitro fertilization (IVF) center. Patient(s): 60 poor-responder patients undergoing 120 IVF cycles. Intervention(s): Addition of luteal estradiol to the standard IVF protocol. Main Outcome Measure(s): Number of embryos with >= 7 cells on day 3 of development. Result(S): The luteal phase estradiol protocol showed a statistically significantly greater number of embryos with >= 7 cells, oocytes retrieved, mature oocytes, and embryos than did the standard protocol. There was no difference between the two protocols with respect to basal antral follicle count, days of stimulation, number of follicles >= 14 mm on day of surge, or endometrial thickness on day of surge. A trend toward improved pregnancy outcomes was found with the luteal estradiol protocol. Conclusion(s): Giving estradiol in the luteal phase preceding IVF hyperstimulation increases the number and the quality of embryos achieved in patients deemed to have a poor response to WE Ultimately, this may translate into improved pregnancy outcomes in these patients. C1 [Frattarelli, John L.; Miller, Kathleen A.; Bergh, Paul A.; Scott, Richard T., Jr.] Reprod Med Associates New Jersey, Morristown, NJ USA. [Hill, Micah J.; McWilliams, Grant D. E.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Frattarelli, JL (reprint author), Reprod Med Associates New Jersey, 100 Franklin Sq Dr,Suite 200, Somerset, NJ 08873 USA. EM jfrattarelli@rmanj.com RI Hill, Micah/A-6777-2009 NR 20 TC 33 Z9 36 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD MAY PY 2008 VL 89 IS 5 BP 1118 EP 1122 DI 10.1016/j.fertnstert.2007.05.025 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 303XY UT WOS:000256075700014 PM 17658529 ER PT J AU Torres, DM Harrison, SA AF Torres, Dawn M. Harrison, Stephen A. TI Diagnosis and therapy of nonalcoholic steatohepatitis SO GASTROENTEROLOGY LA English DT Review ID FATTY LIVER-DISEASE; HEPATIC INSULIN-RESISTANCE; GASTRIC BYPASS-SURGERY; C-REACTIVE PROTEIN; PLACEBO-CONTROLLED TRIAL; II RECEPTOR ANTAGONIST; METABOLIC SYNDROME; OBESE-PATIENTS; WEIGHT-LOSS; VITAMIN-E AB increasing prevalence of obesity, insulin resistance, and the metabolic syndrome has significant implications for the future of chronic liver disease. The resultant increase in the number of patients with nonalcoholic fatty liver disease (NAFLD) is expected to translate into increased numbers of patients with end-stage liver disease (cirrhosis), liver failure, and hepatocellular carcinoma. It is particularly important to identify the patients who are at greatest risk of these aforementioned complications of chronic liver disease, those nonalcoholic fatty liver disease patients with nonalcoholic steatohepatitis. Currently liver biopsy is the gold standard for diagnosis, but less invasive, highly accurate, and affordable screening tools are required. These tools may include radiologic or laboratory studies to identify patients noninvasively who may benefit from therapeutic interventions. Clinical scoring systems that may be used in general practice as initial screening tools also may prove useful. Most therapeutic modalities available or under development target the major pathways thought essential in the pathogenesis of nonalcoholic steatohepatitis and often are directed at reducing body mass index and improving insulin resistance via pharmacologic, surgical, dietary, or exercise regimens. Other potential therapeutic agents directed at cytoprotection or reduction of fibrosis are under investigation. This article focuses on diagnosis and therapy available and under development: for this chronic liver disease. C1 Brooke Army Med Ctr, San Antonio, TX USA. [Harrison, Stephen A.] Dept Gastroenterol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Dept Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil NR 165 TC 196 Z9 207 U1 1 U2 15 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD MAY PY 2008 VL 134 IS 6 BP 1682 EP 1698 DI 10.1053/j.gastro.2008.02.077 PG 17 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 299QX UT WOS:000255771200005 PM 18471547 ER PT J AU Arcone, S Grant, S Boitnott, G Bostick, B AF Arcone, Steven Grant, Steven Boitnott, Ginger Bostick, Benjamin TI Complex permittivity and clay mineralogy of grain-size fractions in a wet slit soil SO GEOPHYSICS LA English DT Article ID TIME-DOMAIN REFLECTOMETRY; DIELECTRIC-PROPERTIES; MICROWAVE-FREQUENCIES; WATER; RELAXATION; SPECTROSCOPY; LOESS; MONTMORILLONITE; KAOLINITE; BEHAVIOR AB We determined the complex permittivity and clay mineralogy of grain-size fractions in a wet silt soil. We used one clay-size fraction and three silt-size fractions, measured permittivity with low error from 25 MHz to 2-4 GHz with time-domain spectroscopy, and estimated mineral weight percentages using X-ray diffraction (XRD). The volumetric water contents were near 30%, and the temperature was 25 degrees C. For the whole soil, standard fractionation procedures yielded 2.4% clay-size particles by weight, but XRD showed that the phyllosilicate clay minerals kaolinite, illite, and smectite made up 17% and were significantly present in all fractions. Above approximately 500MHz, all real pans were similar. Below approximately 500 MHz, the real and imaginary permittivities increased with decreasing grain size as frequency decreased, and the imaginary parts became dominated by direct-current conduction. Similarly, below approximately 500 MHz, the measured permittivity of montmorillonite, a common smectite, dominated that of the other clay minerals. Total clay mineral and smectite mass fractions consistently increased with decreasing grain size. Below 2 GHz, a model with progressively increasing amounts of water and parameters characteristic of montmorillonite matches the data well for all fractions, predicts permittivities characteristic of free water in smectite structural galleries, and shows that the similar real parts above 500 MHz are caused by a small suppression of the high-frequency static value of water permittivity by the smectite. We conclude that the clay mineral content, particularly smectite, appears to be responsible for permittivity variations between grain-size fractions. Small model mismatches in real permittivity near the low-frequency end and the greater fractions of kaolinite and illite suggest that the total clay mineral content might have been important for the coarser fractions. C1 [Arcone, Steven; Grant, Steven; Boitnott, Ginger] USA, Cold Reg Res & Engn Lab, Erdc, Hanover, NH 03755 USA. [Bostick, Benjamin] Dartmouth Coll, Hanover, NH 03755 USA. RP Arcone, S (reprint author), USA, Cold Reg Res & Engn Lab, Erdc, 72 Lyme Rd, Hanover, NH 03755 USA. EM steven.a.arcone@usace.army.mil; steven.a.grant@usace.army.mil; ginger.e.boitnott@usace.army.mil; benjamin.bostick@Dartmouth.edu NR 41 TC 22 Z9 22 U1 2 U2 13 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD MAY-JUN PY 2008 VL 73 IS 3 BP J1 EP J13 DI 10.1190/1.2890776 PG 13 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 313PE UT WOS:000256751700018 ER PT J AU DeMartelaere, SL Roberts, D Burgess, MA Morrison, WH Pisters, PWT Sturgis, EM Ho, V Esmaeli, B AF DeMartelaere, Sheri L. Roberts, Dianna Burgess, Michael A. Morrison, William H. Pisters, Peter W. T. Sturgis, Erich M. Ho, Viet Esmaeli, Bita TI Neoadjuvant chemotherapy-specific and overall treatment outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK LA English DT Article DE angiosarcoma; periorbital; neoadjuvant chemotherapy; eye; surgical resection ID SOFT-TISSUE SARCOMA; ADJUVANT CHEMOTHERAPY; LIPOSOMAL DOXORUBICIN; SCALP; HEAD; NECK; PACLITAXEL AB Background. Recent isolated case reports have suggested a potential role for neoadjuvant chemotherapy in patients with angiosarcoma. The goal of this report was to investigate the overall treatment outcomes and the neoadjuvant chemotherapy-specific outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement. Methods. Our tumor database was searched for patients with angiosarcoma and periorbital involvement seen at our institution between 1981 and 2005. Results, Twenty-one patients were identified,15 of whom had neoadjuvant chemotherapy and 6 of whom had a traditional approach of surgery followed by adjuvant therapy. Fourteen of 15 patients who had neoadjuvant chemotherapy had complete clinical response. Neoadjuvant chemotherapy made definitive surgery unnecessary for 9 patients. The median disease-free interval for the neoadjuvant chemotherapy group was 11.8 months (mean, 38.1 months; range, 2.4-239.6 months). Nine of the 15 patients had recurrences. The time from end of treatment to recurrence ranged from 2.6 to 24.5 months (median, 12.7 months). Five of the 6 patients who had primary surgical resection followed by adjuvant radiotherapy and/or chemotherapy had a complete clinical response, and the median disease-free interval was 31.8 months (mean, 35.9 months; range, 2.7-85 months). Two later developed recurrences, one at 27 months and the other at 31.8 months after the end of treatment. Conclusion. On the basis of this series, the authors conclude that neoadjuvant chemotherapy for periorbital angiosarcoma is a potentially attractive option and in some patients may obviate the need for major surgery, thereby preserving the eye and/or ocular adnexal structures. Given the propensity for recurrence and poor survival, the authors strongly recommend that these patients receive multidisciplinary evaluation and treatment at a major cancer center, (c) 2008 Wiley Periodicals, Inc. C1 [DeMartelaere, Sheri L.; Ho, Viet; Esmaeli, Bita] Univ Texas MD Anderson Canc Ctr, Sect Ophthalmol, Dept Head & Neck Surg, Houston, TX 77030 USA. [DeMartelaere, Sheri L.] Texas Oculoplast Consultants, Austin, TX USA. [DeMartelaere, Sheri L.] Brooke Army Med Ctr, Dept Surg, Sect Ophthalmol, San Antonio, TX USA. [Burgess, Michael A.] Univ Texas MD Anderson Canc Ctr, Dept Sarcoma Med Oncol, Houston, TX 77030 USA. [Morrison, William H.] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA. [Pisters, Peter W. T.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. [Sturgis, Erich M.] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA. RP Esmaeli, B (reprint author), Univ Texas MD Anderson Canc Ctr, Sect Ophthalmol, Dept Head & Neck Surg, Houston, TX 77030 USA. EM besmaeli@mdanderson.org NR 24 TC 15 Z9 16 U1 1 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1043-3074 J9 HEAD NECK-J SCI SPEC JI Head Neck-J. Sci. Spec. Head Neck PD MAY PY 2008 VL 30 IS 5 BP 639 EP 646 DI 10.1002/hed.20757 PG 8 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 296XE UT WOS:000255578300011 PM 18213722 ER PT J AU Cook, MB Graubard, BI Quraishi, SM Yeager, M Chanock, SJ Crenshaw, A Erickson, RL Rubertone, MV Thomas, G McGlynn, KA AF Cook, Michael B. Graubard, Barry I. Quraishi, Sabah M. Yeager, Meredith Chanock, Stephen J. Crenshaw, Andrew Erickson, Ralph L. Rubertone, Mark V. Thomas, Gilles McGlynn, Katherine A. TI Genetic variants in the 8q24 locus and risk of testicular germ cell tumors SO HUMAN GENETICS LA English DT Article ID PROSTATE-CANCER RISK; GENOME-WIDE ASSOCIATION; ANDROGEN RECEPTOR GENE; COLORECTAL-CANCER; CHROMOSOME 8Q24; BREAST-CANCER; FAMILIAL AGGREGATION; SUSCEPTIBILITY LOCI; LOCALIZATION; CONFIRMATION AB Much evidence supports the premise that population genetic variation contributes significantly to the risk of testicular germ-cell tumor (TGCT). However, investigations of the association between genomic markers and TGCT susceptibility are scarce. Single nucleotide polymorphisms (SNPs) at the locus 8q24 have recently been found to be associated with prostate, colorectal and breast cancer. The US Servicemen's testicular tumor environmental and endocrine determinants (STEED) study was used to investigate the association of 15 specific 8q24 SNPs with TGCT and its two main histologic groups of seminoma and nonseminoma. Conditional and unconditional logistic regression models, adjusted for the matching variables of year of birth, race/ethnicity and serum date, were utilized to produce odds ratios (OR) and 95% confidence intervals (95%CI). The analysis included 680 controls and 568 TGCT cases. In the TGCT analysis, no SNP was associated with risk in both heterozygotes and variant homozygotes. When stratified by histology the seminoma analysis also showed no association with the 8q24 SNPs. Conversely, the analysis of nonseminomas had three tentative associations (rs6470494, OR(genotype AG) = 1.15, 95%CI: 0.86-1.54; OR(genotype GG) = 1.68, 95%CI: 1.04-2.73; p for trend = 0.04) (rs13254738, OR(genotype GT) = 1.04, 95%CI: 0.77-1.40; OR(genotype TT) = 1.62, 95%CI: 1.06-2.49; p for trend = 0.07) (rs10505476, OR(genotype CT) = 0.67, 95%CI: 0.50, 0.91; OR(genotype TT) = 0.81, 95%CI: 0.47-1.39; p for trend = 0.04). There was no linkage disequilibrium between any of the 8q24 SNPs analyzed in this population. In conclusion, this study has found little evidence for an association between the reported 8q24 SNPs and TGCTs, although the findings for nonseminoma may be worth further investigation. C1 [Cook, Michael B.; Graubard, Barry I.; Quraishi, Sabah M.; Yeager, Meredith; Chanock, Stephen J.; Crenshaw, Andrew; Thomas, Gilles; McGlynn, Katherine A.] NCI, NIH, DHHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Yeager, Meredith; Crenshaw, Andrew] NCI, SAIC Frederick Inc, Adv Technol Program, Core Genotyping Facil, Frederick, MD 21702 USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, Global Emerging Infect Syst, Silver Spring, MD 20910 USA. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Washington, DC 20307 USA. RP Cook, MB (reprint author), NCI, NIH, DHHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. EM cookmich@mail.nih.gov RI Cook, Michael/A-5641-2009 OI Cook, Michael/0000-0002-0533-7302 FU Intramural NIH HHS [Z99 CA999999] NR 55 TC 9 Z9 9 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0340-6717 J9 HUM GENET JI Hum. Genet. PD MAY PY 2008 VL 123 IS 4 BP 409 EP 418 DI 10.1007/s00439-008-0491-y PG 10 WC Genetics & Heredity SC Genetics & Heredity GA 288AW UT WOS:000254959600009 PM 18373104 ER PT J AU Xu, ZY Sadler, BM AF Xu, Zhengyuan Sadler, Brian M. TI Ultraviolet communications: Potential and state-of-the-art SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article ID AVALANCHE PHOTODIODES AB Motivated by the recent and rapid developments in deep ultraviolet LEDs, solar blind ultraviolet filters, and detectors, this article reviews wireless UV technology used for communications and sensing in either line-of-sight or non-line-of-sight channel conditions. We present the state-of-the-art of associated systems and their components and discuss related issues including communication link characterization, channel modeling, and link capacity study, as well as transceiver design, link duplexing, multiple access, and networking. We also envision applications in the commercial and military sectors. C1 [Xu, Zhengyuan] Univ Calif Riverside, Riverside, CA 92521 USA. [Sadler, Brian M.] USA, Res Lab, Adelphi, MD USA. RP Xu, ZY (reprint author), Univ Calif Riverside, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu; bsadler@arl.army.mil NR 15 TC 124 Z9 142 U1 10 U2 36 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD MAY PY 2008 VL 46 IS 5 BP 67 EP 73 DI 10.1109/MCOM.2008.4511651 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 299TK UT WOS:000255777700005 ER PT J AU Suchalkin, S Westerfeld, D Belenky, G Bruno, JD Pham, J Towner, F Tober, RL AF Suchalkin, Sergey Westerfeld, David Belenky, Gregory Bruno, John D. Pham, John Towner, Fred Tober, Richard L. TI Measurement of semiconductor laser gain by the segmented contact method under strong current spreading conditions SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE interband cascade lasers (ICL); mid-infrared (IR) lasers; optical gain ID INTERBAND CASCADE LASERS; OPTICAL GAIN; ABSORPTION; SPECTRA AB A segmented contact method for the measurement of optical gain is developed for the case of strong current spreading. A simple model of current spreading in a ridge laser with a segmented contact is proposed and analyzed. We show that current spreading effects should be taken into account in lasers with low threshold current densities and high "opening" voltages. When applied to interband cascade lasers, the method gives an internal optical loss of similar to 10-17 cm(-1) and a differential gain of similar to 2.9 cm/A at 80 K, which agrees well with previously reported Hakki-Paoli data. The limitations of the technique are discussed. C1 [Suchalkin, Sergey; Belenky, Gregory] SUNY Stony Brook, Stony Brook, NY 11794 USA. [Westerfeld, David] Power Photon Corp, Stony Brook, NY 11790 USA. [Bruno, John D.; Pham, John; Towner, Fred] Maxion Technol Inc, College Pk, MD 20740 USA. [Tober, Richard L.] USA, Res Lab, Adelphi, MD 20783 USA. RP Suchalkin, S (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA. EM suchal@ece.sunysb.edu; davidwesterfeld@yahoo.com; garik@ece.sunysb.edu; bruno@maxion.com; jpham@maxion.com; ftowner@maxion.com; richt@arl.army.mil NR 16 TC 4 Z9 4 U1 0 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD MAY-JUN PY 2008 VL 44 IS 5-6 BP 561 EP 566 DI 10.1109/JQE.2008.917972 PG 6 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 312VW UT WOS:000256701500021 ER PT J AU Woolard, DL Trew, RJ Polla, DL Stroscio, MA Varshney, U Jensen, J Jensen, JO Lugli, PO Aono, M AF Woolard, Dwight L. Trew, Robert J. Polla, Dennis L. Stroscio, Michael A. Varshney, Usha Jensen, Janet Jensen, James O. Lugli, Paolo O. Aono, Masakazu TI Nanosensors for defense and security SO IEEE SENSORS JOURNAL LA English DT Editorial Material C1 [Woolard, Dwight L.] USA, Res Off, Div Elect, Res Triangle Pk, NC 27709 USA. [Trew, Robert J.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Polla, Dennis L.] Microsyst Technol Off, Arlington, VA 22203 USA. [Stroscio, Michael A.] Univ Illinois, Dept Bioengn & Elect & Comp Engn, Chicago, IL 60607 USA. [Varshney, Usha] Natl Sci Fdn, Div Elect Commun & Cyber Syst, Arlington, VA 22230 USA. [Lugli, Paolo O.] Tech Univ Munich, Inst Nanoelect, D-80333 Munich, Germany. [Aono, Masakazu] Natl Inst Mat Sci, Nanomat Labs, Tsukuba, Ibaraki 3050044, Japan. RP Woolard, DL (reprint author), USA, Res Off, Div Elect, Res Triangle Pk, NC 27709 USA. EM dwight.woolard@us.army.mil; r.trew@ieee.org; dennis.polla@darpa.mil; stroscio@uic.edu; uvarshne@nsf.gov; janet.jensen@us.army.mil; jim.jensen@us.army.mil; aono.masakazu@nims.go.jp NR 0 TC 1 Z9 1 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAY-JUN PY 2008 VL 8 IS 5-6 BP 641 EP 646 DI 10.1109/JSEN.2008.924436 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 342CW UT WOS:000258763200031 ER PT J AU Haynes, AS Gouma, PI AF Haynes, A. S. Gouma, P. I. TI Electrospun conducting polymer-based sensors for advanced pathogen detection SO IEEE SENSORS JOURNAL LA English DT Article DE conductimetric; electrospinning; polyaniline; sensor ID EXHALED BREATH CONDENSATE; CELLULOSE-ACETATE; NITRIC-OXIDE; GAS SENSORS; POLYANILINE; BLENDS; COMPOSITES; PH; TRANSPORT; MARKERS AB This paper focuses on the development of conducting polymer hybrid sensors for pathogen detection for advanced medical diagnostics. Using the electrospinning technique, polyaniline hybrids were developed for the detection of NO gas and for pH monitoring to determine the suitability of these sensors for exhaled human breath analyses. Results show that electrospun hybrids based on leucoemeraldine based polyaniline exhibit sensitivity to NO down to 1 ppm and for the first time, using emeraldine salt polyaniline, demonstrate a conductimetric response to changes in the headspace of aqueous solutions of varying pH. This manuscript discusses the response of these hybrid systems to varying concentrations of pH and NO2. C1 [Haynes, A. S.] USA, Res Dev & Engn Command, Picatinny Arsenal, Picatinny Arsenal, NJ 07806 USA. [Gouma, P. I.] SUNY Stony Brook, Stony Brook, NY 11794 USA. RP Haynes, AS (reprint author), USA, Res Dev & Engn Command, Picatinny Arsenal, Picatinny Arsenal, NJ 07806 USA. EM aisha.s.haynes@us.army.mil; pgouma@notes.cc.sunysb.edu FU U.S. Army ARDEC; National Science Foundation [0304169] FX Manuscript received August 15, 2007; revised December 3, 2007 and February 25, 2008; accepted February 26, 2008. This work was supported in part by the U.S. Army ARDEC and in part by the National Science Foundation under Grant 0304169. The associate editor coordinating the review of this paper and approving it for publication was Dr. Janet Jensen. NR 37 TC 12 Z9 13 U1 4 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAY-JUN PY 2008 VL 8 IS 5-6 BP 701 EP 705 DI 10.1109/JSEN.2008.923039 PG 5 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 342CW UT WOS:000258763200039 ER PT J AU Govind, N Andzelm, J Maiti, A AF Govind, Niranjan Andzelm, Jan Maiti, Amitesh TI Dissociation chemistry of gas molecules on carbon nanotubes - Applications to chemical sensing SO IEEE SENSORS JOURNAL LA English DT Article DE adsorption; carbon nanotubes; chemical sensors; chemisorption; dissociation ID SENSORS; NO2; DEFECTS; ADSORPTION; SOLIDS AB It is well known in the literature that carbon nanotubes (CNTs) interact weakly with many gas molecules like H2O, O-2, CO, NH3, H-2, and NO2, to name a few. Exposure to NO2, O-2, and NH3 significantly affects the electrical conductance of a single wall nanotube (SWNT). These can be explained using a simple charge transfer picture, which results in the observed changes in the hole conduction of the tubes. It is also known that pure SWNTs only weakly interact with these molecules. We have recently investigated (Andzelm et al., 2006) how common defects in CNTs [Stone-Wales (SW), monovacancy, and interstitial] influence the chemisorption of NH3. This paper is a continuation of our previous work. Here, we further investigate, via Density Functional Theory (DFT) calculations, the effects of SW defects on the adsorption/dissociation of O-2 and H2O. We also study the diffusion of adsorbed oxygen atoms on the nanotube surface in the vicinity of the SW defect, as well as the dissociation of NH3 in the presence of adsorbed oxygen atoms. C1 [Govind, Niranjan] Pacific NW Natl Lab, Richland, WA 99352 USA. [Andzelm, Jan] USA, Res Lab, Aberdeen Proving Ground, MD 21010 USA. [Maiti, Amitesh] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA. RP Govind, N (reprint author), Pacific NW Natl Lab, Richland, WA 99352 USA. EM niri.govind@pnl.gov; jandzelm@arl.army.mil; maiti2@llnl.gov RI Govind, Niranjan/D-1368-2011 FU Pacific Northwest National Laboratory (PNNL); U.S. Department of Energy [DE-AC06-76RLO 1830]; DOE's Office of Biological and Environmental Research; U.S. Department of Energy; University of California LLNL [W-7405-Eng-48] FX Manuscript received January 21, 2008; revised February 13, 2008; accepted February 14, 2008. This work at Pacific Northwest National Laboratory (PNNL) was supported in part by the U.S. Department of Energy under Contract DE-AC06-76RLO 1830 (Office of Biological and Environmental Research, EMSL operations). The Pacific Northwest National Laboratory is operated by Battelle Memorial Institute. EMSL operations are supported by the DOE's Office of Biological and Environmental Research. The work at Lawrence Livermore National Laboratory, Livermore (LLNL) was performed under the auspices of the U.S. Department of Energy by the University of California LLNL under Contract W-7405-Eng-48. NR 25 TC 10 Z9 10 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAY-JUN PY 2008 VL 8 IS 5-6 BP 837 EP 841 DI 10.1109/JSEN.2008.923947 PG 5 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 342CW UT WOS:000258763200060 ER PT J AU Zhang, WD Woolard, DL AF Zhang, Weidong Woolard, Dwight L. TI Magneto-transport physics in superlattices with staggered-bandgap structure SO IEEE SENSORS JOURNAL LA English DT Article DE interband tunneling; Landau quantization; magneto-transport; population inversion AB Physical models are presented to describe magneto-transports within double-barrier structure with staggered-band lineups. Here, a special case, where the magnetic field is perpendicular to the heterolayers, is considered and the conduction-band electron current is calculated. In addition, the spatial charge transfer due to the heavyhole (HH) interband tunneling is also studied. The interband tunneling probability is related to the Landau index number, which characterizes the quantization of in-plane electron motions. As a consequence, the inversion of hole populations between Landau levels is shown to occur which is a new phenomenon that has relevance for millimeterwave amplification. C1 [Zhang, Weidong] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Woolard, Dwight L.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Zhang, WD (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM wzhang5@ncsu.edu; dwight.woolard@us.army.mil FU National Research Council Postdoctoral Research Associateship Program FX Manuscript received August 2, 2007: accepted December 18, 2007. This work was supported in part by the National Research Council Postdoctoral Research Associateship Program. The associate editor coordinating the review of this paper and approving it for publication was Prof. Robert Trew. NR 9 TC 0 Z9 0 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAY-JUN PY 2008 VL 8 IS 5-6 BP 914 EP 921 DI 10.1109/JSEN.2008.922722 PG 8 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 342CW UT WOS:000258763200073 ER PT J AU Dhawan, A Gerhold, MD Muth, JF AF Dhawan, Anuj Gerhold, Michael D. Muth, John F. TI Plasmonic structures based on subwavelength apertures for chemical and biological sensing applications SO IEEE SENSORS JOURNAL LA English DT Article DE nanoholes; optical fibers; sensors; surface plasmons ID EXTRAORDINARY OPTICAL-TRANSMISSION; HOLE ARRAYS; ENHANCED TRANSMISSION; RESONANCE SPECTROSCOPY; GOLD NANOPARTICLES; FILMS; MODEL AB Periodic arrays of apertures with subwavelength dimensions and submicron periodicity were fabricated on gold-coated tips of silica optical fibers using focused ion beam (FIB) milling. Interaction of light with subwavelength structures such as an array of nanoapertures in an optically thick metallic film leads to the excitation of surface plasmon waves at the interfaces of the metallic film and the surrounding media, thereby leading to a significant enhancement of light at certain wavelengths. The spectral position and magnitude of the peaks in the transmission spectra depend on the refractive index of the media surrounding metallic film containing the nanohole array. This lays the foundation for the development of fiber-optic chemical and biological sensors that sense the change in refractive index of the medium around the metallic film. This is demonstrated by testing the sensors with solutions of alcohols with different refractive indices and by the attachment of biomolecules to the sensor surface. The bulk refractive index sensitivity of these nanoaperture array-based sensors is shown to be higher than what has been typically reported for metallic nanoparticle-based plasmonic sensors. C1 [Dhawan, Anuj; Gerhold, Michael D.] USA, Res Off, Durham, NC 27703 USA. RP Dhawan, A (reprint author), USA, Res Off, Durham, NC 27703 USA. EM anuj.dhawan@duke.edu; mike.gerhold@us.army.mil; muth@ncsu.edu RI Muth, John/E-9027-2012 OI Muth, John/0000-0002-2488-7721 FU U.S. Army Research Office; National Institute of Health's Carolina Center of Cancer Nanotechnology Excellence FX This work was supported in part by the U.S. Army Research Office and in part by the National Institute of Health's Carolina Center of Cancer Nanotechnology Excellence. The associate editor coordinating the review of this paper and approving it for publication was Dr. Dennis Polla. NR 31 TC 40 Z9 40 U1 5 U2 29 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAY-JUN PY 2008 VL 8 IS 5-6 BP 942 EP 950 DI 10.1109/JSEN.2008.923933 PG 9 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 342CW UT WOS:000258763200077 ER PT J AU Pennington, G Ervin, MH Wickenden, AE AF Pennington, Gary Ervin, Matthew H. Wickenden, Alma E. TI Sensitivity of carbon nanotube transistors to a charged dielectric coating SO IEEE SENSORS JOURNAL LA English DT Article DE carbon nanotubes; phonon scattering; remote charge scattering; sensor devices ID FIELD-EFFECT TRANSISTORS; PHONON-SCATTERING; BAND-STRUCTURE; SINGLE; SENSORS; NANOSENSORS; NANOWIRES; ACTUATION; MOBILITY; FILMS AB This paper investigates the electronic properties of single-walled carbon nanotube field-effect transistors (SWCNT-FETs) in which the SWCNT element is coated with a charged dielectric. The presence of remote charge on the surface of the dielectric is considered to effect carrier transport in the nanotube as a result of both carrier-scattering and gate screening. Nanotube device characteristics are simulated using the multisubband Boltzmann transport method incorporating scattering from both phonons and remote charges. This allows assessment of the sensitivity of a nanotube FET to the presence of a charged dielectric coating during room temperature operation. Results show remote charge scattering affects the diameter (d) dependence of the peak conductance and peak field-effect mobility of carbon nanotube devices. Under phonon-limited transport conditions, these peak values increase as similar to d and similar to d(2), respectively. When remote charge scattering is significant, peak values cease to vary with diameter once a critical diameter reached. Charge scattering is found to particularly degrade device current at gate voltages that allow carriers scattering into or out of a subband minimum. Furthermore, simulations show that intersubband scattering resulting from asymmetry in the circumferential remote charge density becomes increasingly important as the nanotube length decreases. The authors propose that remote charge scattering effects may be applicable in sensing devices allowing for the identification of the charge on a functionalized CNT coating. C1 [Pennington, Gary; Ervin, Matthew H.; Wickenden, Alma E.] USA, Res Lab, Adelphi, MD 20783 USA. RP Pennington, G (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM gary.pennington@arl.army.mil; matthew.ervin@us.army.mil; alma.wickenden@us.army.mil NR 51 TC 1 Z9 1 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAY-JUN PY 2008 VL 8 IS 5-6 BP 1028 EP 1035 DI 10.1109/JSEN.2008.923218 PG 8 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 342CW UT WOS:000258763200088 ER PT J AU Gribok, AV Buller, MJ Reifman, J AF Gribok, Andrei V. Buller, Mark J. Reifman, Jaques TI Individualized short-term core temperature prediction in humans using biomathematical models SO IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING LA English DT Article DE core temperature prediction; data-driven model; first-principles model; heat injury; hybrid model; regularization; time-series analysis ID NEURAL NETWORKS; WIDE-RANGE; RESPONSES; HEAT; WORK AB This study compares and contrasts the ability of three different mathematical modeling techniques to predict individual-specific body core temperature variations during physical activity. The techniques include a first-principles, physiology-based (SCENARIO) model, a purely data-driven model, and a hybrid model that combines first-principles and data-driven components to provide an early, short-term (20-30 min ahead) warning of an impending heat injury. Their performance is investigated using two distinct datasets, a Field study and a Laboratory study. The results indicate that, for up to a 30 min prediction horizon, the purely data-driven model is the most accurate technique, followed by the hybrid. For this prediction horizon, the first-principles SCENARIO model produces root mean square prediction errors that are twice as large as those obtained with the other two techniques. Another important finding is that, if properly regularized and developed with representative data, data-driven and hybrid models can be made "portable" from individual to individual and across studies, thus significantly reducing the need for collecting developmental data and constructing and tuning individual-specific models. C1 [Gribok, Andrei V.; Reifman, Jaques] USAMRMC, TATRC, Biotechnol High Performance Comp Software Appl In, Ft Detrick, MD 21702 USA. [Buller, Mark J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Reifman, J (reprint author), USAMRMC, TATRC, Biotechnol High Performance Comp Software Appl In, Ft Detrick, MD 21702 USA. EM agribok@bioanalysis.org; mark.j.buller@us.army.mil; jaques.reiftnan@us.army.mil NR 31 TC 9 Z9 9 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9294 J9 IEEE T BIO-MED ENG JI IEEE Trans. Biomed. Eng. PD MAY PY 2008 VL 55 IS 5 BP 1477 EP 1487 DI 10.1109/TBME.2007.913990 PG 11 WC Engineering, Biomedical SC Engineering GA 290US UT WOS:000255148600002 PM 18440893 ER PT J AU Chen, Y Zhao, Q Swami, A AF Chen, Yunxia Zhao, Qing Swami, Ananthram TI Joint design and separation principle for opportunistic spectrum access in the presence of sensing errors SO IEEE TRANSACTIONS ON INFORMATION THEORY LA English DT Article; Proceedings Paper CT 8th IEEE Workshop on Signal Processing Advances in Wireless Communications CY JUN 17-20, 2007 CL Helsinki, FINLAND SP IEEE DE cognitive radio; opportunistic spectrum access; partially observable Markov decision process (POMDP) AB Opportunistic spectrum access (OSA) that allows secondary users to independently search for and exploit instantaneous spectrum availability is considered. The design objective is to maximize the throughput of a secondary user while limiting the probability of colliding with primary users. Integrated in the joint design are three basic components: a spectrum sensor that identifies spectrum opportunities, a sensing strategy that determines which channels in the spectrum to sense, and an access strategy that decides whether to access based on potentially erroneous sensing out-comes. This joint design is formulated as a constrained partially observable Markov decision process (POMDP), and a separation principle is established. The separation principle reveals the optimality of myopic policies for the design of the spectrum sensor and the access strategy, leading to closed-form optimal solutions. Furthermore, it decouples the design of the sensing strategy from that of the spectrum sensor and the access strategy, and reduces the constrained POMDP to an unconstrained one. Numerical examples are provided to study the tradeoff between sensing time and transmission time, the interaction between the physical layer spectrum sensor and the MAC layer sensing and access strategies, and the robustness of the ensuing design to model mismatch. C1 [Chen, Yunxia; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Chen, Y (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. EM yxchen@ece.ucdavis.edu; qzhao@ece.ucdavis.edu; aswami@arl.army.mil NR 27 TC 205 Z9 223 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9448 J9 IEEE T INFORM THEORY JI IEEE Trans. Inf. Theory PD MAY PY 2008 VL 54 IS 5 BP 2053 EP 2071 DI 10.1109/TIT.2008.920248 PG 19 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 295WU UT WOS:000255505700012 ER PT J AU Osier, FHA Fegan, G Polley, SD Murungi, L Verra, F Tetteh, KKA Lowe, B Mwangi, T Bull, PC Thornas, AW Cavanagh, DR McBride, JS Lanar, DE Mackinnon, MJ Conway, DJ Marsh, K AF Osier, Faith H. A. Fegan, Gregory Polley, Spencer D. Murungi, Linda Verra, Federica Tetteh, Kevin K. A. Lowe, Brett Mwangi, Tabitha Bull, Peter C. Thornas, Alan W. Cavanagh, David R. McBride, Jana S. Lanar, David E. Mackinnon, Margaret J. Conway, David J. Marsh, Kevin TI Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria SO INFECTION AND IMMUNITY LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; ERYTHROCYTE-BINDING ANTIGEN-175; INVASION-INHIBITORY ANTIBODIES; NATURALLY ACQUIRED-IMMUNITY; NEW-GUINEAN CHILDREN; SURFACE PROTEIN-1; SERUM ANTIBODIES; MONOCLONAL-ANTIBODIES; TERMINAL FRAGMENT; ESCHERICHIA-COLI AB Individuals living in areas where malaria is endemic are repeatedly exposed to many different malaria parasite antigens. Studies on naturally acquired antibody-mediated immunity to clinical malaria have largely focused on the presence of responses to individual antigens and their associations with decreased morbidity. We hypothesized that the breadth (number of important targets to which antibodies were made) and magnitude (antibody level measured in a random serum sample) of the antibody response were important predictors of protection from clinical malaria. We analyzed naturally acquired antibodies to five leading Plasmodium falciparum merozoite-stage vaccine candidate antigens, and schizont extract, in Kenyan children monitored for uncomplicated malaria for 6 months (n = 119). Serum antibody levels to apical membrane antigen 1 (AMA1) and merozoite surface protein antigens (MSP-1 block 2, MSP-2, and MSP-3) were inversely related to the probability of developing malaria, but levels to MSP-1(19) and erythrocyte binding antigen (EBA-175) were not. The risk of malaria was also inversely associated with increasing breadth of antibody specificities, with none of the children who simultaneously had high antibody levels to five or more antigens experiencing a clinical episode (17/119; 15%; P = 0.0006). Particular combinations of antibodies (AMA1, MSP-2, and MSP-3) were more strongly predictive of protection than others. The results were validated in a larger, separate case-control study whose end point was malaria severe enough to warrant hospital admission (n = 387). These findings suggest that under natural exposure, immunity to malaria may result from high titers antibodies to multiple antigenic targets and support the idea of testing combination blood-stage vaccines optimized to induce similar antibody profiles. C1 [Osier, Faith H. A.; Fegan, Gregory; Murungi, Linda; Lowe, Brett; Mwangi, Tabitha; Bull, Peter C.; Mackinnon, Margaret J.; Marsh, Kevin] CGMRC, KEMRI, Kilifi, Kenya. [Osier, Faith H. A.; Fegan, Gregory; Polley, Spencer D.; Verra, Federica; Tetteh, Kevin K. A.; Conway, David J.] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England. [Mackinnon, Margaret J.] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England. [Verra, Federica] Univ Roma La Sapienza, Dipartimento Sci Sanita Pubblica, Sez Parassitol, I-00185 Rome, Italy. [Thornas, Alan W.] BPRC, Dept Parasitol, NL-2280 GH Rijswijk, Netherlands. [Cavanagh, David R.; McBride, Jana S.] Univ Edinburgh, Sch Biomed Sci, Inst Immunol & Infect Res, Edinburgh EH9 3JT, Midlothian, Scotland. [Lanar, David E.] Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. [Conway, David J.] MRC Labs, Banjul, Gambia. RP Osier, FHA (reprint author), CGMRC, KEMRI, POB 230-80108, Kilifi, Kenya. EM fosier@kilifi.kemri-wellcome.org RI Lanar, David/B-3560-2011; Cavanagh, David/A-1828-2008; Polley, Spencer/F-7766-2013; Mackinnon, Margaret/L-3155-2013 OI Osier, Faith/0000-0001-7133-5375; Conway, David/0000-0002-8711-3037; Bull, Peter/0000-0002-7674-6752; Fegan, Greg/0000-0002-2663-2765; Mackinnon, Margaret/0000-0003-1279-9625 FU Medical Research Council [MC_U190081993]; Wellcome Trust [073591] NR 69 TC 178 Z9 180 U1 2 U2 11 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 2008 VL 76 IS 5 BP 2240 EP 2248 DI 10.1128/IAI.01585-07 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 292LJ UT WOS:000255267200050 PM 18316390 ER PT J AU Bulimo, WD Garner, JL Schnabel, DC Bedno, SA Njenga, MK Ochieng, WO Amukoye, E Magana, JM Simwa, JM Ofula, VO Lifumo, SM Wangui, J Breiman, RF Martin, SK AF Bulimo, Wallace D. Garner, Jason L. Schnabel, David C. Bedno, Sheryl A. Njenga, M. Kariuki Ochieng, Walter O. Amukoye, Evans Magana, James M. Simwa, James M. Ofula, Victor O. Lifumo, Samwel M. Wangui, Julia Breiman, Robert F. Martin, Samuel K. TI Genetic analysis of H3N2 influenza A viruses isolated in 2006-2007 in Nairobi, Kenya SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Genetic variant; H3N2; influenza A; Kenya ID POLYMERASE CHAIN-REACTION; SEQUENCE ALIGNMENT; SWISS-MODEL; PROTEIN; ANTIBODY; M2 AB Background Minimal influenza surveillance has been carried out in sub-Saharan Africa to provide information on circulating influenza subtypes for the purpose of vaccine production and monitoring trends in virus spread and mutations. Objective The aim of this study was to investigate a surveillance program in Kenya to isolate and characterize influenza viruses. Results In the 2006-2007 influenza season, nine influenza A viruses were isolated. All were of H3N2 subtype with key amino acid (aa) changes indicating that they were more closely related to recent World Health Organization recommended vaccine strains than to older vaccine strains, and mirroring the evolution of circulating influenza A globally. Hemagglutination inhibition data showed that the 2006 Kenya isolates had titers identical to the 2005-2006 H3N2 vaccine strain but two-to threefold lower titers to the 2006-2007 vaccine strain, suggesting that the isolates were antigenic variants of the 2006-2007 vaccine strains. Analysis of aa substitutions of hemagglutinin-1 (HA1) protein of the 2006 Kenyan viruses revealed unique genetic variations with several aa substitutions located at immunodominant epitopes of the HA1 protein. These mutations included the V112I change at site E, the K 173 E substitution at site D and N 278 K change at site C, mutations that may result in conformational change on the HA molecule to expose novel epitopes thus abrogating binding of preexisting antibodies at these sites. Conclusion Characterization of these important genetic variations in influenza A viruses isolated from Kenya highlights the importance of continuing surveillance and characterization of emerging influenza drift variants in sub-Saharan Africa. C1 [Bulimo, Wallace D.; Wangui, Julia] USA, Med Res Unit, Kenya Med Res Inst, Nairobi 00621, Kenya. [Garner, Jason L.] USAF, Inst Operat Hlth, San Antonio, TX USA. [Bedno, Sheryl A.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Njenga, M. Kariuki; Breiman, Robert F.] Int Emerging Infect Program Kenya, Ctr Dis Control & Prevent, Nairobi, Kenya. [Schnabel, David C.; Martin, Samuel K.] USA, Med Res Unit Kenya, Nairobi 00621, Kenya. RP Bulimo, WD (reprint author), USA, Med Res Unit Kenya, Box 606,Village Market, Nairobi 00621, Kenya. EM wbulimo@wrp-nbo.org RI Bulimo, Wallace/B-1982-2014 OI Bulimo, Wallace/0000-0001-8475-0586 FU US Department of Defense through the Global Emerging Infections Surveillance and Response System (DoD-GEIS) FX Funds for this study were provided by US Department of Defense through the Global Emerging Infections Surveillance and Response System (DoD-GEIS). The views expressed are those of the authors and should not be construed to represent the position of the United States Department of the Army or Department of Defense. The Division of Epidemiology, Air Force Institute of Operational Health, Brooks City Base, San Antonio Texas carried out quality control and quality assurance and sequenced the HA1 gene segment of the viruses described in this publication. This manuscript has been published with permission of Director, KEMRI, Kenya. NR 24 TC 9 Z9 9 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2008 VL 2 IS 3 BP 107 EP 113 DI 10.1111/j.1750-2659.2008.00044.x PG 7 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 467SA UT WOS:000267761500004 PM 19453470 ER PT J AU Viswanathan, M Gajendiran, S Venkatesan, R AF Viswanathan, Madhubalan Gajendiran, S. Venkatesan, R. TI Understanding and enabling marketplace literacy in subsistence contexts: The development of a consumer and entrepreneurial literacy educational program in South India SO INTERNATIONAL JOURNAL OF EDUCATIONAL DEVELOPMENT LA English DT Article DE literacy; international education; consumer literacy; entrepreneurial literacy; marketplace literacy; subsistence marketplaces ID POVERTY AB To function in the economic realm, two important resources that individuals need are finances and know-how. Whereas there has been considerable attention on microfinancing, we describe an educational program that focuses on enabling generic skills about the marketplace and complements these important efforts. We conducted research aimed at understanding lives and marketplaces in subsistence contexts in urban and rural parts of a state in South India. We used the research as a basis for developing a consumer and entrepreneurial literacy educational program. This program uses the "know-why", or an understanding of marketplaces, as a basis for the know-how of being an informed buyer or seller. Despite the difficulties with abstract thinking that low-literate individuals experience, we enable deeper understanding of marketplaces by leveraging the social skills that participants bring to the program and relating educational content back to their lived experiences. Such understanding can enable individuals to place themselves on a path to lifelong learning. Implications of this work for research and practice in non-formal education are discussed. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Viswanathan, Madhubalan] Univ Illinois, Coll Business, Champaign, IL 61820 USA. [Gajendiran, S.; Venkatesan, R.] USA, Marketpl Literacy Project, Champaign, IL USA. [Gajendiran, S.; Venkatesan, R.] SDV Educ Trust, Madras, Tamil Nadu, India. RP Viswanathan, M (reprint author), Univ Illinois, Coll Business, 61 Wohlers Hall,1206 S 6th St, Champaign, IL 61820 USA. EM mviswana@uiuc.edu NR 47 TC 17 Z9 18 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0738-0593 J9 INT J EDUC DEV JI Int. J. Educ. Dev. PD MAY PY 2008 VL 28 IS 3 BP 300 EP 319 DI 10.1016/j.ijedudev.2007.05.004 PG 20 WC Education & Educational Research SC Education & Educational Research GA 281CP UT WOS:000254474500007 ER PT J AU Yemelyanova, AV Cosin, JA Bidus, MA Boice, CR Seidman, JD AF Yemelyanova, A. V. Cosin, J. A. Bidus, M. A. Boice, C. R. Seidman, J. D. TI Pathology of stage I versus stage III ovarian carcinoma with implications for pathogenesis and screening SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE ovarian carcinoma; prognosis; screening; staging ID SEROUS CARCINOMA; CLINICOPATHOLOGICAL ANALYSIS; PROGNOSTIC FACTORS; TUMOR DIAMETER; CANCER; ADENOCARCINOMA; CISPLATIN; SURVIVAL; WOMEN AB The progression of ovarian carcinoma from stage I when it is confined to the ovaries and curable to disseminated abdominal disease, which is usually fatal, is poorly understood. An accurate understanding of this process is fundamental to designing, testing, and implementing an effective screening program for ovarian cancer. Pathologic features of the primary ovarian tumors in 41 FIGO stage I ovarian carcinomas were compared with those in 40 stage III carcinomas. The primary ovarian tumors in stage I cases, when compared with stage 111, respectively, were significantly larger (15.4 versus 9.8 cm), were less frequently bilateral (12% versus 75%), more frequently contained a noninvasive component (88% versus 30%), had a higher proportion of a noninvasive component (42% versus 8%), and were more often nonserous (83% versus 20%) (P < 0.001 for all five comparisons). There are significant pathologic differences between the primary ovarian tumors in stage I and III ovarian carcinomas that are very difficult to explain by a simple temporal progression. These findings along with the growing body of literature suggest that early- and advanced-stage ovarian cancers are in many instances biologically different entities. This knowledge may have significant implications for our understanding of the biology of early- and advanced-stage ovarian cancer and therefore on the development of screening strategies for ovarian cancer. C1 [Yemelyanova, A. V.; Seidman, J. D.] Washington Hosp Ctr, Dept Pathol & Lab Med, Washington, DC 20010 USA. [Cosin, J. A.; Boice, C. R.] Washington Hosp Ctr, Dept Obstet & Gynecol, Washington, DC 20010 USA. [Bidus, M. A.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. RP Seidman, JD (reprint author), Washington Hosp Ctr, Dept Pathol, 110 Irving St,NW, Washington, DC 20010 USA. EM jeffrey.d.seidman@medstar.net NR 34 TC 20 Z9 20 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1048-891X J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD MAY-JUN PY 2008 VL 18 IS 3 BP 465 EP 469 DI 10.1111/j.1525-1438.2007.01058.x PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 303QI UT WOS:000256055200012 PM 17868343 ER PT J AU Clayton, JD AF Clayton, John D. TI A model for deformation and fragmentation in crushable brittle solids SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE fragmentation; damage mechanics; thermodynamics; statistical physics; concrete ID HIGH-STRAIN RATES; HIGH-VELOCITY IMPACT; DYNAMIC FRAGMENTATION; CRYSTAL PLASTICITY; SIZE DISTRIBUTION; MICROPLANE MODEL; HIGH-PRESSURES; DAMAGE MODEL; PART II; CONCRETE AB A unified framework of continuum elasticity, inelasticity, damage mechanics, and fragmentation in crushable solid materials is presented. A free energy function accounts for thermodynamics of elastic deformation and damage, and thermodynamically admissible kinetic relations are given for inelastic rates (i.e., irreversible strain and damage evolution). The model is further specialized to study concrete subjected to ballistic loading. Numerical implementation proceeds within a finite element context in which standard continuum elements represent the intact solid and particle methods capture eroded material. The impact of a metallic, spherical projectile upon a planar concrete target and the subsequent motion of the resulting cloud of concrete debris are simulated. Favorable quantitative comparisons are made between the results of simulations and experiments regarding residual velocity of the penetrator, mass of destroyed material, and crater and hole sizes in the target. The model qualitatively predicts aspects of the fragment cloud observed in high-speed photographs of the impact experiment, including features of the size and velocity distributions of the fragments. Additionally, two distinct methods are evaluated for quantitatively characterizing the mass and velocity distributions of the debris field, with one method based upon a local energy balance and the second based upon global entropy maximization. Finally, the model is used to predict distributions of fragment masses produced during impact crushing of a concrete sphere, with modest quantitative agreement observed between results of simulation and experiment. (c) 2007 Elsevier Ltd. All rights reserved. C1 USA, Res Lab, Impact Phys Branch, AMSRD ARL WM TD, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, Impact Phys Branch, AMSRD ARL WM TD, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil RI Clayton, John/C-7760-2009 NR 71 TC 22 Z9 22 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAY PY 2008 VL 35 IS 5 BP 269 EP 289 DI 10.1016/j.ijimpeng.2007.02.002 PG 21 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 268FL UT WOS:000253564400001 ER PT J AU Su, ZB Peng, W Zhang, ZY Gogos, G Skaggs, R Cheeseman, B AF Su, Zhenbi Peng, Wen Zhang, Zhaoyan Gogos, George Skaggs, Reed Cheeseman, Bryan TI Numerical simulation of a novel blast wave mitigation device SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE blast wave; mitigation; numerical simulation ID SHOCK-WAVES; ATTENUATION; EXPLOSIVES; PROTECTION; AIRBLAST; WALLS AB This paper proposes a novel blast wave mitigation device, consisting of a piston-cylinder assembly. A shock wave is induced inside the device when it is subject to a blast wave. The shock wave propagates inside the device and is reflected repeatedly. The physical processes within the blast wave mitigation device are simulated numerically. Numerical predictions are in excellent agreement with analytical solutions for special cases of the investigated problem that are available in the literature. The peak pressure on the base of the device caused by the blast wave is studied using a number of design parameters. The numerical simulation shows that, although the transmitted impulse remains practically unchanged, the peak pressure of the blast wave can be reduced by as much as 98%, or even higher, depending on the design parameters chosen. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Su, Zhenbi; Peng, Wen; Zhang, Zhaoyan; Gogos, George] Univ Nebraska, Dept Mech Engn, Lincoln, NE 68588 USA. [Skaggs, Reed; Cheeseman, Bryan] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, ZY (reprint author), Univ Nebraska, Dept Mech Engn, Lincoln, NE 68588 USA. EM zzhang5@unl.edu NR 19 TC 8 Z9 8 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAY PY 2008 VL 35 IS 5 BP 336 EP 346 DI 10.1016/j.ijimpeng.2007.04.001 PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 268FL UT WOS:000253564400005 ER PT J AU Tracy, FT AF Tracy, F. T. TI One-, two-, and three-dimensional solutions for counter-current steady-state two-phase subsurface flow SO INTERNATIONAL JOURNAL OF MULTIPHASE FLOW LA English DT Article DE two-phase subsurface flow; oil-water modeling; analytical solutions; testing numerical models ID POROUS-MEDIA AB This paper derives analytical solutions for steady-state one-dimensional (1-D), two-dimensional (2-D), and three-dimensional (3-D) two-phase immiscible subsurface flow for a counter-current problem. Since the governing equations are highly nonlinear, 2-D and 3-D derivations are generally difficult to obtain. The primary purpose for the solutions is to test finite difference/volume/element computer programs for accuracy and scalability using architectures ranging from PCs to parallel high performance computers. This derivation is accomplished by first solving for the saturation of water in terms of a function that is a solution to Laplace's equation to achieve a set of partial differential equations that allows some degree of latitude in the choice of boundary conditions. Separation of variables and Fourier series are used to obtain the final solution. The test problem consists of a rectangular block of soil where specified pressure is applied at the top and bottom of the sample, and no-flow boundary conditions are imposed on the sides. The pressure at the top of the sample is a step function that allows the testing of adaptive meshing or concentration of grid points in action zones. (c) 2008 Published by Elsevier Ltd. C1 USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Tracy, FT (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Fred.T.Tracy@.usace.army.mil NR 19 TC 2 Z9 2 U1 3 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0301-9322 J9 INT J MULTIPHAS FLOW JI Int. J. Multiph. Flow PD MAY PY 2008 VL 34 IS 5 BP 437 EP 446 DI 10.1016/j.ijmultiphaseflow.2007.02.011 PG 10 WC Mechanics SC Mechanics GA 294VC UT WOS:000255433400002 ER PT J AU Lim, JW Strawn, RC AF Lim, Joon W. Strawn, Roger C. TI Computational modeling of HART II blade-vortex interaction loading and wake system SO JOURNAL OF AIRCRAFT LA English DT Article; Proceedings Paper CT AIAA 45th Aerospace Sciences Meeting and Exhibit CY JAN 08-11, 2007 CL Reno, NV SP Amer Inst Aeronaut & Astronaut ID INTERACTION AIRLOADS; PREDICTION AB Correlations using a loosely coupled trim methodology of the computational fluid dynamics (OVERFLOW-2) and computational structural dynamics (CAMRAD-II) codes are presented to calculate the helicopter rotor blade-vortex interaction airloads and wake system for the higher-harmonic aeroacoustic rotor test (HART 11) rotor at an advance ratio of 0.15. Five different grid models are studied to quantify the effects of 1 rid refinement on rotor-wake resolution. The fine grid model has a total of 113 million grid points and it improves airload predictions compared with the standard grid model for three HART 11 test cases: baseline, minimum noise, and minimum vibration. The rotor-wake positions are well predicted by this fine grid model. The computed vorticity field for a young vortex using the fine grid model is compared with the measured particle image velocimetry data and the results are good. The fine grid model underpredicts the experimental value for the maximum vorticity by 61%. The predicted vortex core radius is 15% in chord for the fine grid while the measured data show about 5% chord length. The predicted swirl velocity is, however, higher than the measured data for this vortex. The results in this paper provide the first quantitative comparisons between the measured and computational fluid dynamics/computational structural dynamics computed flowfield for a helicopter rotor-wake system. C1 [Lim, Joon W.; Strawn, Roger C.] USA, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA USA. RP Lim, JW (reprint author), USA, Ames Res Ctr, Aeroflightdynam Directorate AMRDEC, M-S 215-1, Moffett Field, CA USA. NR 24 TC 9 Z9 9 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD MAY-JUN PY 2008 VL 45 IS 3 BP 923 EP 933 DI 10.2514/1.31081 PG 11 WC Engineering, Aerospace SC Engineering GA 312RN UT WOS:000256688600016 ER PT J AU Frehlich, R Sharman, R Clough, C Padovani, M Fling, K Boughers, W Walton, WS AF Frehlich, Rod Sharman, Robert Clough, Charles Padovani, Michael Fling, Kelly Boughers, Ward Walton, W. Scott TI Effects of atmospheric turbulence on ballistic testing SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article ID DOPPLER LIDAR PERFORMANCE; WIND TURBULENCE; SIMULATION; TERRAIN; SPECTRA AB The effects of atmospheric turbulence on munition target scatter are determined from numerical simulations of ballistic trajectories through many realizations of realistic simulated turbulent wind fields. A technique is evaluated for correcting for the effects of turbulence on ballistic testing procedures by using a line of sonic anemometer measurements taken along the trajectory path. The metric used to evaluate the correction is the difference between the target impact scatter produced with and without the use of the anemometers in the trajectory calculations. The improvement in the testing procedure as measured by this metric is determined as a function of the number of sonic anemometers in the line and the sonic averaging time interval. The performance of the simulations is also compared with data from a field test for a standard small-caliber munition, and the predicted and observed target scatter are in good qualitative agreement, supporting the feasibility of the approach. C1 [Frehlich, Rod; Sharman, Robert] Natl Ctr Atmospher Res, Boulder, CO 80303 USA. [Frehlich, Rod] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Clough, Charles; Padovani, Michael; Fling, Kelly; Boughers, Ward; Walton, W. Scott] USA, Aberdeen Proving Ground, MD USA. RP Frehlich, R (reprint author), Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80303 USA. EM rgf@cires.colorado.edu NR 14 TC 1 Z9 1 U1 0 U2 3 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD MAY PY 2008 VL 47 IS 5 BP 1539 EP 1549 DI 10.1175/2007JAMC1775.1 PG 11 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 311BH UT WOS:000256574500019 ER PT J AU Almeida, JL Harper, B Cole, KD AF Almeida, J. L. Harper, B. Cole, K. D. TI Bacillus anthracis spore suspensions: determination of stability and comparison of enumeration techniques SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE Bacillus anthracis; DNA extraction; quantitative PCR; spores; stability; storage ID REAL-TIME PCR; DEOXYRIBONUCLEIC ACID; SEQUENCE; DNA; IDENTIFICATION; GENOME; CELLS AB Aim: To determine the stability and variability in concentration of spore suspensions of Bacillus anthracis (BA) spore suspensions by comparing different methods of enumeration and to detect changes, if any, under different storage conditions. Methods and Results: Plate and microscope counts were compared to measuring the genomic equivalents based on DNA content BA spore suspensions. We developed chemical methods to extract spore DNA and extra-spore (ES) DNA. DNA mass was determined by gel electrophoresis and QPCR assays were developed using the markers on the chromosome (rpoB) and the pXO1 plasmid (pag). The plate counts and microscope counts were very stable (for up to 900 days). The effect of freezing and the presence of additives in samples were tested for up to 300 days, and the results indicated that the additives tested and freezing did not decrease the viability or microscope counts. Conclusions: Bacillus anthracis spore suspensions can be stored for long periods of time without significant loss of viability or clumping. The content of ES DNA was variable and changed with time. Significant and Impact of the Study: The study shows that BA spore suspensions can be developed for reference materials providing a uniform basis for comparing detection equipment and results from different laboratories. C1 [Almeida, J. L.; Cole, K. D.] NIST, Div Biochem Sci, Chem Sci & Technol Lab, Gaithersburg, MD 20899 USA. [Harper, B.] USA, Dugway, UT USA. RP Cole, KD (reprint author), NIST, Div Biochem Sci, Chem Sci & Technol Lab, Mailstop 8312,100 Bur Dr, Gaithersburg, MD 20899 USA. EM kenneth.cole@nist.gov NR 19 TC 9 Z9 9 U1 0 U2 6 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1364-5072 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD MAY PY 2008 VL 104 IS 5 BP 1442 EP 1448 DI 10.1111/j.1365-2672.2007.03684.x PG 7 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 287XR UT WOS:000254950500024 PM 18194254 ER PT J AU Radek, KA Baer, LA Eckhardt, J DiPietro, LA Wade, CE AF Radek, Katherine A. Baer, Lisa A. Eckhardt, Jennifer DiPietro, Luisa A. Wade, Charles E. TI Mechanical unloading impairs keratinocyte migration and angiogenesis during cutaneous wound healing SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE tissue repair; rat; skin ID ENDOTHELIAL GROWTH-FACTOR; BED REST; SIMULATED MICROGRAVITY; MAMMALIAN-CELLS; RESPONSES; RAT; INACTIVITY; LIGAMENT; REPAIR; TISSUE AB Although initially thought to improve an individual's ability to heal, mechanical unloading promoted by extended periods of bed rest has emerged as a contributing factor to delayed or aberrant tissue repair. Using a rat hindlimb unloading (HLU) model of hypogravity, we mimicked some aspects of physical inactivity by removing weight-bearing loads from the hindlimbs and producing a systemic cephalic fluid shift. This model simulates bed rest in that the animal undergoes physiological adaptations, resulting in a reduction in exercise capability, increased frequency of orthostatic intolerance, and a reduction in plasma volume. To investigate whether changes associated with prior prolonged bed rest correlate with impaired cutaneous wound healing, we examined wound closure, angiogenesis, and collagen content in day 2 to day 21 wounds from rats exposed to HLU 2 wk before excisional wounding. Wound closure was delayed in day 2 wounds from HLU rats compared with ambulatory controls. Although the levels of proangiogenic growth factors, fibroblast growth factor-2 (FGF-2), and vascular endothelial growth factor (VEGF) were similar between the two groups, wound vascularity was significantly reduced in day 7 wounds from HLU animals. To further examine this disparity, total collagen content was assessed but found to be similar between the two groups. Taken together, these results suggest that keratinocyte and endothelial cell function may be impaired during the wound healing process under periods of prolonged inactivity or bed rest. C1 [Baer, Lisa A.; Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Radek, Katherine A.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA. [Radek, Katherine A.; Baer, Lisa A.; Eckhardt, Jennifer; Wade, Charles E.] NASA, Ames Res Ctr, Div Life Sci, Moffett Field, CA 94035 USA. [DiPietro, Luisa A.] Univ Illinois, Coll Dent, Ctr Wound Healing & Tissue Regenerat, Chicago, IL USA. RP Wade, CE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM charles.wade@amedd.army.mil NR 63 TC 11 Z9 12 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAY PY 2008 VL 104 IS 5 BP 1295 EP 1303 DI 10.1152/japplphysiol.00977.2007 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 295VB UT WOS:000255500900010 PM 18292299 ER PT J AU Ryan, KL Cooke, WH Rickards, CA Lurie, KG Convertino, VA AF Ryan, Kathy L. Cooke, William H. Rickards, Caroline A. Lurie, Keith G. Convertino, Victor A. TI Breathing through an inspiratory threshold device improves stroke volume during central hypovolemia in humans SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE lower body negative pressure; hypotension; inspiratory resistance ID BODY NEGATIVE-PRESSURE; VENOUS RETURN CURVE; BLOOD-PRESSURE; CARDIOPULMONARY-RESUSCITATION; ORTHOSTATIC HYPOTENSION; HEMODYNAMIC-RESPONSES; HEMORRHAGIC-SHOCK; CARDIAC-OUTPUT; PULSE CONTOUR; UPRIGHT TILT AB Inspiratory resistance induced by breathing through an impedance threshold device (ITD) reduces intrathoracic pressure and increases stroke volume (SV) in supine normovolemic humans. We hypothesized that breathing through an ITD would also be associated with a protection of SV and a subsequent increase in the tolerance to progressive central hypovolemia. Eight volunteers (5 men, 3 women) were instrumented to record ECG and beat-by-beat arterial pressure and SV (Finometer). Tolerance to progressive lower body negative pressure (LBNP) was assessed while subjects breathed against either 0 (sham ITD) or -7 cmH(2)O inspiratory resistance (active ITD); experiments were performed on separate days. Because the active ITD increased LBNP tolerance time from 2,014 +/- 106 to 2,259 +/- 138 s (P = 0.006), data were analyzed (time and frequency domains) under both conditions at the time at which cardiovascular collapse occurred during the sham experiment to determine the mechanisms underlying this protective effect. At this time point, arterial blood pressure, SV, and cardiac output were higher (P <= 0.005) when breathing on the active ITD rather than the sham ITD, whereas indirect indicators of autonomic activity (low-and high-frequency oscillations of the R-to-R interval) were not altered. ITD breathing did not alter the transfer function between systolic arterial pressure and R-to-R interval, indicating that integrated baroreflex sensitivity was similar between the two conditions. These data show that breathing against inspiratory resistance increases tolerance to progressive central hypovolemia by better maintaining SV, cardiac output, and arterial blood pressures via primarily mechanical rather than neural mechanisms. C1 [Ryan, Kathy L.; Rickards, Caroline A.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cooke, William H.] Univ Texas San Antonio, San Antonio, TX USA. [Lurie, Keith G.] Adv Circulatory Syst Inc, Eden Prairie, MN USA. [Lurie, Keith G.] Hennepin Cty Med Ctr, Dept Emergency Med, Minneapolis, MN 55415 USA. RP Ryan, KL (reprint author), USA, Inst Surg Res, Bldg 3611,3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM kathy.ryan@amedd.army.mil NR 52 TC 31 Z9 31 U1 0 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAY PY 2008 VL 104 IS 5 BP 1402 EP 1409 DI 10.1152/japplphysiol.00439.2007 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 295VB UT WOS:000255500900023 PM 18309096 ER PT J AU Brenner, M Kreuter, K Ju, J Mahon, S Seng, L Mukai, D Burney, T Guo, SG Su, JP Tran, A Batchinsky, A Cancio, LC Narula, N Chen, ZP AF Brenner, Matthew Kreuter, Kelly Ju, Johnny Mahon, Sari Seng, Lillian Mukai, David Burney, Tanya Guo, Shuguang Su, Jianping Tran, Andrew Batchinsky, Andriy Cancio, Leopoldo C. Narula, Navneet Chen, Zhongping TI In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE optical coherence tomography; smoke inhalation injury; bronchial; tracheal; fiber optic probe ID MORPHOLOGIC CHANGES; BARRETTS-ESOPHAGUS; MICROSTRUCTURE; BRONCHOSCOPY; DIAGNOSIS; SEVERITY; IMAGES; SCANS; BURN; LUNG AB Smoke inhalation injury causes acute airway injury that may result in airway compromise with significant morbidity and mortality. We investigate the ability of high resolution endobronchial optical coherence tomography (OCT) to obtain real-time images for quantitatively assessing regional differences between upper tracheal versus lower tracheal and bronchial airway injury responses to smoke inhalation in vivo using a prototype spectral domain (SLD)-OCT system we constructed, and flexible fiber optic probes. 33 New Zealand White rabbits are intubated and mechanically ventilated. The treatment groups are exposed to inhaled smoke. The OCT probe is introduced through the endotracheal tube and maintained in place for 5 to 6 h. Images of airway mucosa and submucosa are obtained at baseline and at specified intervals postexposure. Starting within less than 15 min after smoke inhalation, there is significant airway thickening in the smoke-exposed animals. This is maintained over 5 h of imaging studies. The lower tracheal airway changes, correlating closely with carboxyhemoglobin levels, are much greater than upper tracheal changes. Significant differences are seen in lower trachea and bronchi after acute smoke inhalation compared to upper trachea as measured in vivo by minimally invasive OCT. OCT is capable of quantitatively detecting regional changes in airway swelling following inhalation injury. (C) 2008 Society of Photo-Optical Instrumentation Engineers. C1 [Brenner, Matthew; Ju, Johnny; Seng, Lillian; Tran, Andrew] Univ Calif Irvine, Div Pulm & Crit Care, Irvine Med Ctr, Orange, CA 92868 USA. [Brenner, Matthew; Kreuter, Kelly; Mahon, Sari; Mukai, David; Burney, Tanya; Guo, Shuguang; Su, Jianping; Chen, Zhongping] Univ Calif Irvine, Irvine Beckman Laser Inst, Irvine, CA 92612 USA. [Batchinsky, Andriy; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Narula, Navneet] Univ Calif Irvine, Irvine Med Ctr, Div Pathol, Orange, CA 92868 USA. RP Brenner, M (reprint author), Univ Calif Irvine, Div Pulm & Crit Care, Irvine Med Ctr, 101 City Dr S,Bldg 53,Rm 119, Orange, CA 92868 USA. EM mbrenner@uci.edu FU NCI NIH HHS [CA-91717, R01 CA091717-05, R01 CA091717]; NCRR NIH HHS [P41 RR001192-29, P41 RR001192]; NIBIB NIH HHS [R01 EB000293-07, EB-000293, R01 EB000293] NR 33 TC 15 Z9 16 U1 1 U2 3 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 J9 J BIOMED OPT JI J. Biomed. Opt. PD MAY-JUN PY 2008 VL 13 IS 3 AR 034001 DI 10.1117/1.2939400 PG 8 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA 330NX UT WOS:000257951200029 PM 18601546 ER PT J AU Richard, RL Hedman, TL Quick, CD Barillo, DJ Cancio, LC Renz, EM Chapman, TT Dewey, WS Dougherty, ME Esselman, PC Forbes-Duchart, L Franzen, BJ Hunter, H Kowalske, K Moore, ML Nakamura, DY Nedelec, B Niszczak, J Parry, I Serghiou, M Ward, RS Holcomb, JB Wolf, SE AF Richard, Reginald L. Hedman, Travis L. Quick, Charles D. Barillo, David J. Cancio, Leopoldo C. Renz, Evan M. Chapman, Ted T. Dewey, William S. Dougherty, Mary E. Esselman, Peter C. Forbes-Duchart, Lisa Franzen, Beth J. Hunter, Hope Kowalske, Karen Moore, Merilyn L. Nakamura, Dana Y. Nedelec, Bernedette Niszczak, Jon Parry, Ingrid Serghiou, Michael Ward, R. Scott Holcomb, John B. Wolf, Steven E. TI A clarion to recommit and reaffirm burn rehabilitation SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID QUALITY-OF-LIFE; THERMAL-INJURY; CONTRACTURES; EXPERIENCE; SHORTAGE; CHILDREN; THERAPY AB Burn rehabilitation has been a part of burn care and treatment for many years. Yet, despite of its longevity, the rehabilitation outcome of patients with severe burns is less than optimal and appears to have leveled off. Patient survival from burn injury is at an all-time high. Burn rehabilitation must progress to the point where physical outcomes parallel survival statistics in terms of improved patient well-being. This position article is a treatise on burn rehabilitation and the state of burn rehabilitation patient outcomes. It describes burn rehabilitation interventions in brief and why a need is felt to bring this issue to the forefront. The article discusses areas for change and the challenges facing burn rehabilitation. Finally., the relegation and acceptance of this responsibility are addressed. C1 [Richard, Reginald L.; Hedman, Travis L.; Quick, Charles D.; Barillo, David J.; Cancio, Leopoldo C.; Renz, Evan M.; Chapman, Ted T.; Dewey, William S.; Holcomb, John B.; Wolf, Steven E.] USA, Burn Rehabil Dept, Inst Surg Res, ATTN MCMR USC PT, Ft Sam Houston, TX 78234 USA. [Dougherty, Mary E.] Shriners Burns Inst, OT PT Dept, Cincinnati, OH USA. [Esselman, Peter C.; Moore, Merilyn L.] Harborview Med Ctr, Dept Rehabil Med, Seattle, WA USA. [Franzen, Beth J.] Reg Burn Ctr, Burn Rehabil Dept, St Paul, MN USA. [Forbes-Duchart, Lisa] Hlth Sci Ctr, Winnipeg, MB, Canada. [Hunter, Hope] New York Presbyterian Hosp, Weill Cornell Med Ctr, Dept Rehabil Med, New York, NY USA. [Kowalske, Karen] Parkland Mem Hosp & Affiliated Inst, Dept Phys Med & Rehabil, Dallas, TX 75235 USA. [Nakamura, Dana Y.] Wake Forest Univ, Burn Ctr, Winston Salem, NC 27109 USA. [Nedelec, Bernedette] McGill Univ, Sch Phys & Occupat Therapy, Montreal, PQ, Canada. [Niszczak, Jon] Bio Med Sci Inc, Allentown, PA USA. [Parry, Ingrid] Shriners Burns Inst, Rehabil Dept, Sacramento, CA USA. [Serghiou, Michael] Shriners Burns Inst, Burn Rehabil Dept, Galveston, TX USA. [Ward, R. Scott] Univ Utah, Div Phys Therapy, Salt Lake City, UT USA. RP Richard, RL (reprint author), USA, Burn Rehabil Dept, Inst Surg Res, ATTN MCMR USC PT, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 53 TC 25 Z9 26 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD MAY-JUN PY 2008 VL 29 IS 3 BP 425 EP 432 DI 10.1097/BCR.0b013e318171081d PG 8 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 300TT UT WOS:000255848800001 PM 18388581 ER PT J AU Regules, JA Horvath, LL Chung, KK AF Regules, Jason A. Horvath, Lynn L. Chung, Kevin K. TI Invasive Vibrio cholerae infection following burn injury SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID SURVEILLANCE; DISEASE AB Vibrio cholerae is a pathogen predominantly appreciated for its potential to produce life-threatening watery diarrhea, usually without invasive disease. However, nonepidemic forms, which are present worldwide, may have a severe invasive presentation, especially among those with liver disease or other immunocompromised states. We present a case of invasive infection (pulmonary, wound, and bacteremia) by nonepidemic V. cholerae, in a soldier that sustained burn injury in Iraq. Multiple factors, to include burn injury and water exposure, likely contributed to this presentation. A brief discussion of the pertinent literature is included. C1 [Regules, Jason A.; Horvath, Lynn L.] Brooke Army Med Ctr, Infect Dis MCHE MDI, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Regules, JA (reprint author), Brooke Army Med Ctr, Infect Dis MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 13 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD MAY-JUN PY 2008 VL 29 IS 3 BP 551 EP 554 DI 10.1097/BCR.0b013e31817111f6 PG 4 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 300TT UT WOS:000255848800019 PM 18388568 ER PT J AU Boddu, VM Abburi, K Maloney, SW Damavarapu, R AF Boddu, Veera M. Abburi, Krishnaiah Maloney, Stephen W. Damavarapu, Reddy TI Thermophysical properties of an insensitive munitions compound, 2,4-dinitroanisole SO JOURNAL OF CHEMICAL AND ENGINEERING DATA LA English DT Article ID PREDICTION; WATER AB Accurate values of thermophysical properties of toxic chemical compounds over a range of temperatures are essential for understanding their environmental distribution, biotransformation, and development of potential water treatment processes. In this study, the aqueous solubility (s(w)), octanol-water partition coefficient (K-ow) and Henry's law constant (k(H)) were measured for an insensitive munitions compound, 2,4-dinitroanisole (DNAN), at the temperatures of (298.15, 308.15, and 318.15) K. The effect of ionic environment on solubility, using electrolytes such as NaCl and CaCl2, was also studied. The data on the thermophysical parameters were correlated using the standard van't Hoff equation. All three properties exhibited a linear relationship with reciprocal temperature. The enthalpy and entropy of phase transfer were derived from the experimental data. C1 [Boddu, Veera M.; Abburi, Krishnaiah; Maloney, Stephen W.] USA Engineer Res & Dev Ctr, CERL, Environm Proc Branch, Champaign, IL 61822 USA. [Damavarapu, Reddy] USA Armament Res Dev & Engn Ctr, Energet & Warheads Div, Picatinny Arsenal, NJ 07806 USA. RP Boddu, VM (reprint author), USA Engineer Res & Dev Ctr, CERL, Environm Proc Branch, 2902 Newmark Dr, Champaign, IL 61822 USA. EM veera.boddu@usace.army.mil NR 22 TC 28 Z9 29 U1 1 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-9568 J9 J CHEM ENG DATA JI J. Chem. Eng. Data PD MAY PY 2008 VL 53 IS 5 BP 1120 EP 1125 DI 10.1021/je7006764 PG 6 WC Thermodynamics; Chemistry, Multidisciplinary; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA 297ZM UT WOS:000255655900012 ER PT J AU Wang, XY Pang, JH Newman, RA Kerwin, SM Bowman, PD Stavchansky, S AF Wang, Xinyu Pang, Jihai Newman, Robert A. Kerwin, Sean M. Bowman, Phillip D. Stavchansky, Salomon TI Quantitative determination of fluorinated caffeic acid phenethyl ester derivative from rat blood plasma by liquid chromatography-electrospray ionization tandem mass spectrometry SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE caffeic acid phenethyl ester; fluorinated caffeic acid phenethyl ester; rat blood plasma; UPLC-ESI-MS/MS ID NUCLEAR-FACTOR; KAPPA-B; CELLS; CAPE; PROPOLIS; EXPRESSION; INTEGRASE AB The quantitative determination of caffeic acid phenethyl ester (CAPE) and its fluorinated derivative (FCAPE) from rat plasma using ultra-performance liquid chromatography with electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) is reported. CAPE and FCAPE were extracted using ethyl acetate in the presence of methyl caffeate (MC) as internal standard. Separation was achieved using a C(18) column (2.1 mm x 50 mm, 1.7 mu m) and gradient elution with water and acetonitrile containing 0.2% and 0.1% formic acid, respectively. A non-linear response over a broad concentration range (1-1000 ng/ml, r(2) > 0.995 using a quadratic regression model and 1/concentration weighting) was obtained. The inter-day and intra-day variability for CAPE and FCAPE were found to be less than 14.2% and 9.5%, respectively. Data are presented to illustrate the practicality of the method for the pharmacokinetic evaluation of CAPE and FCAPE after intravenous administration to rats. (C) 2008 Elsevier B.V. All rights reserved. C1 [Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. [Pang, Jihai; Newman, Robert A.] Univ Texas Houston, MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77054 USA. [Kerwin, Sean M.] Univ Texas Austin, Div Med Chem, Austin, TX 78712 USA. [Kerwin, Sean M.] Univ Texas Austin, Inst Cell & Mol Biol, Austin, TX 78712 USA. [Wang, Xinyu; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Stavchansky, S (reprint author), Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. EM stavchansky@mail.utexas.edu NR 17 TC 5 Z9 6 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD MAY 1 PY 2008 VL 867 IS 1 BP 138 EP 143 DI 10.1016/j.jchromb.2008.02.025 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 305TJ UT WOS:000256200400022 PM 18358795 ER PT J AU Jones, KA AF Jones, K. A. TI Structural analyses for SiC and AlGaN grown on off-axis 4H-and 6H-SiC SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE lattice mismatch; heteroepitaxy; gallium nitride; silicon carbide ID LIGHT-EMITTING-DIODES; MOLECULAR-BEAM EPITAXY; SINGLE-CRYSTALS; GALLIUM NITRIDE; QUANTUM-WELLS; DEFECTS; 11(2)OVER-BAR0; SAPPHIRE; FILMS; PERFORMANCE AB In an effort to identify low-surface-energy, close-packed, conducive-to-growth hexagonal semi-polar planes on which micropipe free SiC crystals and/or hetero-epitaxial AlGaN structures with a reduced piezoelectric field and a smaller lattice mismatch can be grown, an orientation relationship between the cubic 3C and nH hexagonal structures was developed. Specific hexagonal planes corresponding to the (10 0)c and (1 11)c cubic planes were found, and equations were developed to determine the planar structure and packing density of these planes to assess whether there is a good chance that high-quality material can be grown on these surfaces, and, if so, whether it is likely that stacking faults will be formed. It is shown that stacking faults will likely form in SiC crystals grown on the hexagonal nH (3 (3) over bar 0 2n)(H) and (3 (3) over bar 0 (n) over bar)(H) planes, which correspond to the (1 0 0)(C) and (1 (1 1) over bar)(C) cubic 3C planes. It is also shown that good epitaxy of AlGaN films should be possible on these planes although it is likely stacking faults will be formed. The % Al for which there is no lattice mismatch in the direction containing a component parallel to the c-axis is 95.4 and 83.3 for growth on the 4H (3 (3) over bar 0 8) and (3 (3) over bar 0 (4) over bar) planes, and 88.3 and 76.9 for growth on the 6H (1 (1) over bar 0 4) and (1 (1) over bar 0 (2) over bar) planes. Published by Elsevier B.V. C1 USA, Res Lab, SEDD, Adelphi, MD 20783 USA. RP Jones, KA (reprint author), USA, Res Lab, SEDD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ken.a.jones@us.army.mil NR 31 TC 3 Z9 3 U1 4 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 EI 1873-5002 J9 J CRYST GROWTH JI J. Cryst. Growth PD MAY 1 PY 2008 VL 310 IS 10 BP 2417 EP 2426 DI 10.1016/j.jcrysgro.2007.08.007 PG 10 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 306GX UT WOS:000256237400001 ER PT J AU Kim, JS Trivedi, SB Soos, J Gupta, N Palosz, W AF Kim, Joo-Soo Trivedi, Sudhir B. Soos, Jolanta Gupta, Neelam Palosz, Witold TI Growth of Hg2Cl2 and Hg2Br2 single crystals by physical vapor transport SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE purification; growth from vapor; halides; acousto-optic materials; filters ID FILTERS; DEVICES AB Large crystals of Hg2Cl2 and Hg2Br2 (48 mm in diameter, up to 600 g in weight) have been grown by the physical vapor transport (PVT) technique in closed ampoules in vertical configuration without contact with the ampoule walls. The starting materials have been pre-purified by resublimation. Seed selection has been accomplished by having a narrow tubing at the tip of the growth ampoule. Thermochemical analysis of the system is done and discussed. The grown crystals show good transparency and good crystallographic quality. An acousto-optic modulator built from the Hg2Cl2 crystal showed good performance consistent with predicted device parameters. (C) 2008 Published by Elsevier B.V. C1 [Kim, Joo-Soo; Trivedi, Sudhir B.; Soos, Jolanta; Palosz, Witold] Brimrose Corp Amer, Sparks, MD 21152 USA. [Gupta, Neelam] USA, Res Lab, AMSRD ARL SE EE, Adelphi, MD 20783 USA. RP Palosz, W (reprint author), Brimrose Corp Amer, 19 Loveton Circle, Sparks, MD 21152 USA. EM wpalosz@brimrose.com RI Gupta, Neelam/B-8702-2013 NR 26 TC 15 Z9 16 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 EI 1873-5002 J9 J CRYST GROWTH JI J. Cryst. Growth PD MAY 1 PY 2008 VL 310 IS 10 BP 2457 EP 2463 DI 10.1016/j.jcrysgro.2007.12.067 PG 7 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 306GX UT WOS:000256237400007 ER PT J AU Jonas, C Capell, C Burk, A Zhang, QC Callanan, R Agarwal, A Geil, B Scozzie, C AF Jonas, Charlotte Capell, Craig Burk, Al Zhang, Qingchun Callanan, Robert Agarwal, Anant Geil, Bruce Scozzie, Charles TI 1200 V4H-SiC bipolar junction transistors with a record beta of 70 SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE semiconductor; silicon carbide; SiC; BJT; bipolar; MOSFET; IGBT; current gain AB A common current gain of 70 has been achieved in 4H-SiC bipolar junction transistors (BJTs) at room temperature, which is the highest among those reported. BJTs having an active area of 4 mm x 4 mm exhibit a specific on-resistance of 6.3 m Omega cm(2) at 25 degrees C, which increases to 17.4 m Omega cm(2) at 250 degrees C. BVCEO (the breakdown voltage from collector to emitter with open base) and BVCBO (the breakdown voltage from collector to base with open emitter) of 1200 V were observed at < 5 mu A leakage currents at all temperatures up to 250 degrees C. Dynamic characteristics were measured using the IXYS RF/Directed Energy IXDD415 gate driver evaluation board to drive the BJT. A collector current (I (C)) rise time at turn-on of 32 ns was measured with a 1.6 A gate current provided to support the collector current of 63 A. An I (C) fall time at turn-off of 16 ns was achieved. C1 [Jonas, Charlotte; Capell, Craig; Burk, Al; Zhang, Qingchun; Callanan, Robert; Agarwal, Anant] Cree Inc, Res Triangle Pk, NC 27709 USA. [Geil, Bruce; Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA. RP Jonas, C (reprint author), Cree Inc, 3026 E Cornwallis Rd, Res Triangle Pk, NC 27709 USA. EM Charlotte_Jonas@cree.com NR 6 TC 8 Z9 8 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD MAY PY 2008 VL 37 IS 5 BP 662 EP 665 DI 10.1007/s11664-007-0331-1 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 289CU UT WOS:000255033400023 ER PT J AU Taylor, CL Taylor, SF AF Taylor, Charles L. Taylor, Shawn F. TI Atropine autoinjector use as a suicidal gesture SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE atropine; autoinjector; anticholinergic; toxidrome; nerve agent ID PHYSOSTIGMINE; ANTIDOTES AB Atropine autoinjectors are used by the U.S. military as pre-hospital first-line therapy for nerve agent exposure. This case report examines the misuse of these devices in a suicide attempt. An anticholinergic toxidrome resulted from this misuse. The patient was successfully treated. (C) 2008 Published by Elsevier Inc. C1 [Taylor, Charles L.] Womack Army Med Ctr, Dept Emergency Med, Ft Bragg, NC USA. [Taylor, Shawn F.] 7th Special Forces Grp Airborne, Ft Bragg, NC 28310 USA. RP Taylor, SF (reprint author), 7th Special Forces Grp, Ft Bragg, NC 28310 USA. NR 25 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD MAY PY 2008 VL 34 IS 4 BP 397 EP 400 DI 10.1016/j.jemermed.2007.05.037 PG 4 WC Emergency Medicine SC Emergency Medicine GA 296RL UT WOS:000255563400006 PM 17931821 ER PT J AU Dortch, MS Zakikhani, M Kim, SC Steevens, JA AF Dortch, Mark S. Zakikhani, Mansour Kim, Sung-Chan Steevens, Jeffery A. TI Modeling water and sediment contamination of Lake Pontchartrain following pump-out of Hurricane Katrina floodwater SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Lake Pontchartrain; Hurricane Katrina; floodwaters; levee failures; modeling; contaminants; sediments ID 3-DIMENSIONAL MANAGEMENT MODEL; CHESAPEAKE BAY; NEW-ORLEANS; WASHINGTON AB Levee failure and overtopping as a result of Hurricane Katrina caused major flooding of New Orleans, Louisiana. Floodwaters, which were contaminated with heavy metals, organic chemicals, and fecal coliform bacteria (FCB), were pumped into neighboring Lake Pontchartrain during dewatering. The impact of levee failure on water and benthic sediment concentrations in the lake was investigated by applying a numerical water quality model coupled to a three-dimensional, numerical hydrodynamic model. The model was used to compute water and benthic sediment concentrations throughout the lake for lead. arsenic, benzo(a)pyrene (BaP), and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), and water concentrations for FCB. Computed concentrations resulting from actual pumped discharges with levee failure and overtopping were compared to computed concentrations resulting from pumped discharges without levee failure or overtopping, and concentrations from both sets of conditions were compared to ecological water and sediment quality screening guideline values. The model indicated that incremental increases above pre-Katrina benthic sediment concentrations are about a factor of 10 greater with dewatering of the floodwaters than with dewatering of storm water without flooding. However, these increases for the metals are small relative to pre-Katrina concentrations. The results showed that the ecological screening-level sediment quality guideline values were exceeded for BaP and DDE in areas near the south shoreline of the lake as a result of floodwater pump-out, whereas, this was not the case for storm water removal without flooding. The model showed that lake water column concentrations should be about the same during both dewatering conditions regardless of whether there is flooding or not. Published by Elsevier Ltd. C1 [Dortch, Mark S.; Zakikhani, Mansour; Kim, Sung-Chan; Steevens, Jeffery A.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Dortch, MS (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Mark.S.Dortch@erdc.usace.army.mil NR 31 TC 16 Z9 17 U1 2 U2 11 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD MAY PY 2008 VL 87 IS 3 BP 429 EP 442 DI 10.1016/j.jenvman.2007.01.035 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA 287ZK UT WOS:000254955800011 PM 17399885 ER PT J AU Sills, GL Vroman, ND Wahl, RE Schwanz, NT AF Sills, G. L. Vroman, N. D. Wahl, R. E. Schwanz, N. T. TI Overview of New Orleans levee failures: Lessons learned and their impact on national levee design and assessment SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article AB This paper provides an overview of the Southeast Louisiana Flood and Hurricane Protection System that was in place at the time of Hurricane Katrina. Both geography and components of the system are described. A brief description of the development of the storm, the major damage caused, and lessons learned are discussed. C1 [Sills, G. L.; Vroman, N. D.] USACE, GEEB, GSD, GSL,ERDC, Vicksburg, MS 39180 USA. [Wahl, R. E.] USACE, Airfields & Pavements Branch, Engn Syst & Mat Div, GSL,ERDC, Vicksburg, MS 39180 USA. [Schwanz, N. T.] USACE, St Paul, MN 55101 USA. RP Vroman, ND (reprint author), USACE, GEEB, GSD, GSL,ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM george.l.sills@erdc.usace.army.mil; noah.d.vroman@erdc.usace.army.mil; ronald.e.wahl@erdc.usace.army.mil; neil.t.schwanz@usace.army.mil NR 8 TC 38 Z9 39 U1 0 U2 21 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD MAY PY 2008 VL 134 IS 5 BP 556 EP 565 DI 10.1061/(ASCE)1090-0241(2008)134:5(556 PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 291OY UT WOS:000255207900002 ER PT J AU Dunbar, JB Britsch, LD AF Dunbar, Joseph B. Britsch, Louis D., III TI Geology of the New Orleans area and the canal levee failures SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article AB The geologic history of the New Orleans area significantly influences the engineering properties of the foundation soils beneath the levees. Geologic and engineering data gathered from the levee breaches identify a spatially complex geomorphic landscape, caused by Holocene sea level rise, lateral changes in depositional environments, development of Mississippi River delta lobes, and the distributary channels associated with delta development. Overlying the Pleistocene surface beneath New Orleans are predominantly fine-grained. shallow water sediments associated with bay sound (or estuarine), nearshore-gulf, sandy beach, lacustrine, interdistributary, and paludal (marsh and swamp) environments. These environments define the New Orleans area history during the Holocene and comprise the levee foundation beneath the failure areas. A barrier beach ridge is present in the subsurface along the southern shore of Lake Ponchartrain, which blocked the filling of the lake with fluvial-deltaic sediments. This buried beach impacted the supply and texture of sediment being deposited by advancing distributary channels and influenced the engineering properties of these soils. Marsh and swamp soils beneath the failure area at the 17th Street Canal are much thicker in comparison to those beneath the London Avenue Canal failures because of the influence of the beach complex, and are thickest in the Industrial Canal area. Additionally, human activities in the New Orleans area during historic time contributed to the spatial complexity and affected the engineering properties of the foundation soils. These activities include construction of drainage and navigation canals, groundwater pumping, hydraulic filling of the Lake Ponchartrain lake front, and construction of levees to prevent river flooding. Human activities, combined with the geologic setting and subsidence in C1 [Dunbar, Joseph B.] US Army Corps Engineers, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Britsch, Louis D., III] US Army Corps Engineers Dist, New Orleans, LA 70160 USA. RP Dunbar, JB (reprint author), US Army Corps Engineers, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Joseph.B.Dunbar@erdc.usace.army.mil; Louis.D.Britsch@mvn02.usace.army.mil NR 31 TC 6 Z9 6 U1 1 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD MAY PY 2008 VL 134 IS 5 BP 566 EP 582 DI 10.1061/(ASCE)1090-0241(2008)134:5(566) PG 17 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 291OY UT WOS:000255207900003 ER PT J AU Sasanakul, I Vanadit-Ellis, W Sharp, M Abdoun, T Ubilla, J Steedman, S Stone, K AF Sasanakul, Inthuorn Vanadit-Ellis, Wipawi Sharp, Michael Abdoun, Tarek Ubilla, Javier Steedman, Scott Stone, Kevin TI New Orleans levee system performance during Hurricane Katrina: 17th Street Canal and Orleans Canal North SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article AB Centrifuge modeling of the 17th Street Canal and Orleans Canal North levees was performed in this study. During hurricane Katrina the levees on the 17th Street Canal failed, leading to breaches in the outfall canal in the city. Two mechanisms were observed in the centrifuge modeling that could cause a breach. First, a water-filled crack formed in front of the floodwall as the water in the canal rose above the top of the levee. The levees on the 17th Street Canal, which were supported on clay foundations, failed when this cracking led to a translational (sliding) failure in the clay layer commencing at the toe of the floodwall. The levees at Orleans Canal North, where failure did not occur, were also modeled to demonstrate that the model tests could successfully simulate failure and nonfailure conditions. The centrifuge model tests identified the importance of the crack formation in relation to the stability of the floodwall. These tests also confirmed that levee geometry, floodwall depth of penetration, and the underlying soil profile were all critical to the performance of the system under flood loading. C1 [Sasanakul, Inthuorn; Ubilla, Javier] Rensselaer Polytech Inst, CEES Geotech Centrifuge Res Ctr, Troy, NY 12180 USA. [Vanadit-Ellis, Wipawi] USA Corps Engineers, ERDC Centrifuge Res Ctr, Vicksburg, MS 39180 USA. [Sharp, Michael] USA Corps Engineers, Civil Works Infrastruct Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Abdoun, Tarek] Rensselaer Polytech Inst, Dept Civil & Environm Engn, Troy, NY 12180 USA. [Steedman, Scott] High Point Rendel, Grp Strategy, London SE1 1SA, England. [Stone, Kevin] Univ Brighton, Brighton BN2 4GJ, E Sussex, England. RP Sasanakul, I (reprint author), Rensselaer Polytech Inst, CEES Geotech Centrifuge Res Ctr, 110 8th St, Troy, NY 12180 USA. EM sasani@rpi.edu; wipawi.vanadit-ellis@erdc.usace.army.mil; michael.k.sharp@erdc.usace.army.mil; abdout@rpi.edu; ubilj@rpi.edu; s.steedman@highpointrendel.com; kevin.stone@brighton.ac.uk NR 6 TC 11 Z9 11 U1 0 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD MAY PY 2008 VL 134 IS 5 BP 657 EP 667 DI 10.1061/(ASCE)1090-0241(2008)134:5(657) PG 11 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 291OY UT WOS:000255207900009 ER PT J AU Ubilla, J Abdoun, T Sasanakul, I Sharp, M Steedman, S Vanadit-Ellis, W Zimmie, T AF Ubilla, Javier Abdoun, Tarek Sasanakul, Inthuorn Sharp, Michael Steedman, Scott Vanadit-Ellis, Wipawi Zimmie, Thomas TI New Orleans levee system performance during Hurricane Katrina: London Avenue and Orleans Canal South SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article AB Hurricane Katrina was one of the worst natural disasters in U.S. history. The effects of the hurricane were particularly devastating in the city of New Orleans. Most of the damage was due to the failure of the levee system that surrounds the city to protect it from flooding. This paper presents the results of centrifuge models conducted at Rensselaer Polytechnic Institute and the U.S. Army Corps of Engineers simulating the behavior of the levees at London Avenue North and South that failed during Hurricane Katrina. Those levees failed without being overtopped by the storm surge. Also included are the results of a centrifuge model of one levee section at Orleans Canal South, which did not fail during the hurricane. The key factor of the failure mechanism of the London Avenue levees was the formation of a gap between the flooded side of the levee and the sheetpile. This gap triggered a reduction of the strength at the foundation of the protected side of the levee. The results are fully consistent with field observations. C1 [Ubilla, Javier; Sasanakul, Inthuorn] Rensselaer Polytech Inst, CEES Geotech Centrifuge Ctr, Troy, NY 12180 USA. [Abdoun, Tarek; Zimmie, Thomas] Rensselaer Polytech Inst, Dept Civil & Environm Engn, Troy, NY 12180 USA. [Sharp, Michael] Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Steedman, Scott] High Point Rendel, Grp Strategy, London SE1 1SA, England. [Vanadit-Ellis, Wipawi] USA, Centrifuge Res Ctr, Corps Engineers, Vicksburg, MS 31980 USA. RP Ubilla, J (reprint author), Rensselaer Polytech Inst, CEES Geotech Centrifuge Ctr, 110 8th St, Troy, NY 12180 USA. EM ubillj@alum.rpi.edu; abdout@rpi.edu; sasani@rpi.edu; Michael.K.Sharp@erdc.usace.army.mil; s.steedman@highpointrendel.com; Wipawi.Vanadit-Ellis@erdc.usace.army.mil; zimmit@rpi.edu NR 7 TC 20 Z9 20 U1 1 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD MAY PY 2008 VL 134 IS 5 BP 668 EP 680 DI 10.1061/(ASCE)1090-0241(2008)134:5(668) PG 13 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 291OY UT WOS:000255207900010 ER PT J AU Duncan, JM Brandon, TL Wright, SG Vroman, N AF Duncan, J. Michael Brandon, Thomas L. Wright, Stephen G. Vroman, Noah TI Stability of I-walls in New Orleans during Hurricane Katrina SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article AB Failures of I-walls during Hurricane Katrina were responsible for many breaches in the flood protection system in New Orleans. Six breaches were examined in detail by Task Group 7 of the Interagency Performance Evaluation Taskforce. Four of these failures and breaches, which occurred before the water levels reached the top of the wall, were not caused by overtopping erosion. The failure of the I-wall at the 17th Street Canal resulted from shear through the weak foundation clay. The south failure of the London Avenue I-wall was caused by subsurface erosion, which carried massive amounts of sand inland, and removed support for the wall, leading to catastrophic instability. At the north breach on London Avenue, the failure was caused by high pore pressures, combined with a lower friction angle in the loose sand, which resulted in gross instability of the I-wall under the water pressure load from the storm surge. Looking back, with the benefit of 20-20 hindsight, these stability and erosion failures can be explained in terms of modern soil mechanics, exploration techniques, laboratory test procedures, and analysis methods. An important factor in all of the cases investigated was development of a gap behind the wall as the water rose against the wall and caused it to deflect. Formation of the gap increased the load on the wall, because the water pressures in the gap were higher than the earth pressures that had acted on the wall before the gap formed. Where the foundation soil was clay, formation of a gap eliminated the shearing resistance of the soil on the flood side of the wall, because the slip surface stopped at the gap. Where the foundation soil was sand, formation of the gap opened a direct hydraulic connection between the water in the canal and the sand beneath the levee. This hydraulic short circuit made seepage conditions worse, and erosion due to underseepage more likely. It also increased the uplift pressures on the base of the levee and marsh layer landward of the levee, reducing stability. Because gap formation has such important effects on I-wall stability, and because gaps behind I-walls were found in many locations after the storm surge receded, the presence of the gap should always be assumed in I-wall design studies. C1 [Duncan, J. Michael; Brandon, Thomas L.] Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. [Wright, Stephen G.] Univ Texas Austin, Dept Civil Engn, Austin, TX 78712 USA. [Vroman, Noah] USACE ERDC, Vicksburg, MS 39180 USA. RP Brandon, TL (reprint author), Virginia Tech, Dept Civil & Environm Engn, 200 Patton Hall, Blacksburg, VA 24061 USA. EM jmd@vt.edu; tb@vt.edu; swright@mail.utexas.edu; noah.d.vroman@erdc.usace.army.mil NR 7 TC 12 Z9 12 U1 1 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD MAY PY 2008 VL 134 IS 5 BP 681 EP 691 DI 10.1061/(ASCE)1090-0241(2008)134:5(681) PG 11 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 291OY UT WOS:000255207900011 ER PT J AU Khan, LA Wicklein, EA Rashid, M Ebner, LL Richards, NA AF Khan, Liaqat A. Wicklein, Edward A. Rashid, Mizan Ebner, Laurie L. Richards, Natalie A. TI Case study of an application of a computational fluid dynamics model to the forebay of the Dalles Dam, Oregon SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID HYDRAULIC FLOW SIMULATION; FISH DIVERSION; VALIDATION; PLANT AB A proposal for facilitating the downstream migration of juvenile fish at The Dalles Dam, Ore. calls for blocking the upper 12.3 m of turbine intakes by J-shaped steel panels (blocked trashracks). These trashracks are expected to reduce velocity near the powerhouse that is responsible for entraining juveniles into the turbine intake flow. A three-dimensional computational fluid dynamics model was used to investigate the forebay hydraulics for the existing and proposed configurations of the intakes. Velocity data from a 1:40 scale physical model and a field program were utilized for model validation. In general, agreements between computed velocities and data were within the variability of field measurements. The model results confirmed the development of low velocity zones adjacent to the powerhouse. Further, the flow field created by the proposed trashracks could aid juveniles in swimming to the downstream end of the powerhouse where the fish bypass system is located. C1 [Khan, Liaqat A.; Wicklein, Edward A.] ENSR, Redmond, WA 98052 USA. [Rashid, Mizan] ENSR, Water Res Dept, Redmond, WA 98052 USA. [Ebner, Laurie L.; Richards, Natalie A.] US Army Corps Engineers, Portland, OR 97204 USA. RP Khan, LA (reprint author), ENSR, 9521 Willows Rd NE, Redmond, WA 98052 USA. EM lkhan@ensr.aecom.com NR 27 TC 2 Z9 2 U1 1 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD MAY PY 2008 VL 134 IS 5 BP 509 EP 519 DI 10.1061/(ASCE)0733-9429(2008)134:5(509) PG 11 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 291OX UT WOS:000255207800001 ER PT J AU Chang, MH Pang, T Pemy, M AF Chang, Mou-Hsiung Pang, Tao Pemy, Moustapha TI Finite difference approximation for stochastic optimal stopping problems with delays SO JOURNAL OF INDUSTRIAL AND MANAGEMENT OPTIMIZATION LA English DT Article DE optimal stopping; stochastic control; stochastic functional differential equations; finite difference ID JACOBI-BELLMAN EQUATIONS; DIFFUSION-PROCESSES; VISCOSITY SOLUTIONS; OPTION; VOLATILITY; SYSTEMS; MODEL AB This paper considers the computational issue of the optimal stopping problem for the stochastic functional differential equation treated in [ ]. The finite difference method developed by Barles and Souganidis [ ] is used to obtain a numerical approximation for the viscosity solution of the infinite dimensional Hamilton-Jacobi-Bellman variational inequality (HJBVI) associated with the optimal stopping problem. The convergence results are then established. C1 [Chang, Mou-Hsiung] USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. [Pang, Tao] N Carolina State Univ, Dept Math, Raleigh, NC 27695 USA. [Pang, Tao] N Carolina State Univ, Res Ctr Comp Sci, Raleigh, NC 27695 USA. [Pemy, Moustapha] Towson Univ, Dept Math, Towson, MD 21252 USA. RP Chang, MH (reprint author), USA, Res Off, Div Math, POB 12211, Res Triangle Pk, NC 27709 USA. EM mouhsiung.chang@us.army.mil; tpang@ncsu.edu; mpemy@towson.edu NR 51 TC 7 Z9 7 U1 0 U2 1 PU AMER INST MATHEMATICAL SCIENCES PI SPRINGFIELD PA PO BOX 2604, SPRINGFIELD, MO 65801-2604 USA SN 1547-5816 J9 J IND MANAG OPTIM JI J. Ind. Manag. Optim. PD MAY PY 2008 VL 4 IS 2 BP 227 EP 246 PG 20 WC Engineering, Multidisciplinary; Operations Research & Management Science; Mathematics, Interdisciplinary Applications SC Engineering; Operations Research & Management Science; Mathematics GA 279TS UT WOS:000254378200002 ER PT J AU Singh, OV Harvey, SP AF Singh, Om V. Harvey, Steven P. TI Integrating biological processes to facilitate the generation of 'Biofuel' SO JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY LA English DT Editorial Material C1 [Singh, Om V.] Johns Hopkins Sch Med, Dept Pediat, Baltimore, MD 21287 USA. [Harvey, Steven P.] USA, Edgewood Chem Biol Ctr, AMSRD, ECB RT BD, Aberdeen Proving Ground, MD 21010 USA. RP Singh, OV (reprint author), Johns Hopkins Sch Med, Dept Pediat, 600 N Wolfe St,Pk 316, Baltimore, MD 21287 USA. EM osingh1@jhmi.edu; steve.harvey@us.army.mil OI Singh, Om/0000-0002-7537-0415 NR 0 TC 2 Z9 2 U1 0 U2 2 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1367-5435 J9 J IND MICROBIOL BIOT JI J. Ind. Microbiol. Biotechnol. PD MAY PY 2008 VL 35 IS 5 BP 291 EP 292 DI 10.1007/s10295-008-0338-5 PG 2 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 288CM UT WOS:000254963800001 PM 18347827 ER PT J AU Lund, DJ Edsall, P Stuck, BE AF Lund, David J. Edsall, Peter Stuck, Bruce E. TI Spectral dependence of retinal thermal injury SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE laser bioeffects; retinal damage; ocular thresholds; thermal model; action spectrum ID LASER DAMAGE; THRESHOLDS; WAVELENGTH; RADIATION; SIZE; EYE AB The action spectrum for light-induced damage to the retina results from wavelength dependent transmission of the pre-retinal ocular media, wavelength dependent absorption in retinal chromophores, and chromatic aberration of the eye optics. While various light/tissue interaction mechanisms have been implicated, thermal mechanisms dominate in the visible and near-infrared spectrum for all exposure durations shorter than a few seconds and longer than 1 ns. A number of investigators have measured the transmission of the eye and the spectra of retinal absorbers, and thermal models based on these data predict the broad features of the action spectrum. This paper reports dose-response data for 100 ms duration retinal exposure in rhesus monkey to laser irradiation from a tunable Ti:Sapphire laser and from fixed-wavelength lasers over the wavelength range from 413 to 1319 nm. The wavelength dependence of these data is well predicted by the thermal action spectrum. (C) 2008 Laser Institute of America. C1 [Lund, David J.; Edsall, Peter; Stuck, Bruce E.] US Army Med Res Detachment, Walter Reed Army Inst Res, Brooks City Base, TX 78235 USA. RP Lund, DJ (reprint author), US Army Med Res Detachment, Walter Reed Army Inst Res, 7914 Dave Erwin Dr, Brooks City Base, TX 78235 USA. EM jack.lund@brooks.af.mil NR 45 TC 8 Z9 8 U1 1 U2 2 PU LASER INST AMER PI ORLANDO PA 13501 INGENUITY DR, SUITE 128, ORLANDO, FL 32826 USA SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD MAY PY 2008 VL 20 IS 2 BP 76 EP 82 DI 10.2351/1.2900534 PG 7 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA 303NE UT WOS:000256046400003 ER PT J AU Zuclich, JA Edsall, PE Lund, DJ Stuck, BE Till, S Hollins, RC Kennedy, PK McLin, LN AF Zuclich, J. A. Edsall, P. E. Lund, D. J. Stuck, B. E. Till, S. Hollins, R. C. Kennedy, P. K. McLin, L. N. TI New data on the variation of laser induced retinal-damage threshold with retinal image size SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE laser; eye protection; retina; image size; spot size; lesion; damage threshold; thermal model ID MELANIN GRANULE MODEL AB In earlier studies, we examined the dependence of the laser induced retinal damage threshold on retinal image size for extended-source ocular exposures. We reported the spot-size dependence of the retinal threshold (based on ophthalmic observations at 24 It postexposure) for two pulsewidth regimes: nanosecond-duration (Q-switched) pulses from a doubled Nd:yttriuin-aluminum-garnet laser and microsecond-duration pulses from a flashlamp-pumped dye laser at 590 urn. In either case, the retinal threshold was shown to vary with the area (i.e., diameter squared) for image diameters >5 mrad. More recently, we have collected additional data for the intermediate spot-size range (1.5-10 mrad) and have compared both the absolute values and the spot-size trend of retinal thresholds determined via ophthalmoscopic observation at 1 h postexposure to the analogous threshold data collected with observations at 24 h postexposure. These additional data and analyses reinforce our earlier conclusions regarding the threshold vs. spot-size trend and are compared to and reconciled with results from previously published extended-source ocular damage studies. The experimental spot-size trends are also contrasted to the existing laser safety standard treatments of maximum permissible exposure levels for extended-source ocular exposures. (C) 2008 Laser Institute of America. C1 [Zuclich, J. A.; Edsall, P. E.] Northrop Grumman IT, San Antonio, TX 78228 USA. [Lund, D. J.; Stuck, B. E.] US Army Med Res Detachment, Brooks AFB, TX 78235 USA. [Till, S.; Hollins, R. C.] UK Dstl, Malvern WR 143PS, Worcs, England. [Kennedy, P. K.; McLin, L. N.] USAF, Opt Radiat Branch, HEDO, Brooks AFB, TX 78235 USA. RP Zuclich, JA (reprint author), Northrop Grumman IT, 4241 Woodcock Dr,Suite B-100, San Antonio, TX 78228 USA. EM joe.zuclich.ctr@brooks.af.mil NR 21 TC 8 Z9 8 U1 0 U2 5 PU LASER INST AMER PI ORLANDO PA 13501 INGENUITY DR, SUITE 128, ORLANDO, FL 32826 USA SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD MAY PY 2008 VL 20 IS 2 BP 83 EP 88 DI 10.2351/1.2900536 PG 6 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA 303NE UT WOS:000256046400004 ER PT J AU Schulmeister, K Sliney, DH Mellerio, J Lund, DJ Stuck, BE Zuclich, JA AF Schulmeister, Karl Sliney, David H. Mellerio, John Lund, David J. Stuck, Bruce E. Zuclich, Joseph A. TI Review of exposure limits and experimental data for corneal and lenticular damage from short pulsed UV and IR laser radiation SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE laser safety; MPE; exposure limit; eye; cornea; lens; ultraviolet; infrared; pulse ID ULTRAVIOLET-RADIATION; CO2-LASER RADIATION; EPITHELIAL DAMAGE; 400 NM; MU-M; THRESHOLDS; WAVELENGTHS; GUIDELINES; REGION AB Laser exposure limits as promulgated by the International Commission on Non-Ionizing Radiation Protection are compared to relevant experimental animal injury data for cornea and lens exposure in the nanosecond to microsecond pulse duration regime in both the ultraviolet (UV) and infrared spectral ranges. In the UV spectral range, thermal and photochemical damage mechanisms compete and thresholds must be carefully distinguished as a function of wavelength and pulse duration. The thermal UV damage data are compared with levels inferred from CO2 radiation thresholds and it is shown that the reduction factors between experimental data for thermal injury and the corresponding exposure limits appear to be unnecessarily high. The lack of data for nanosecond exposures for wavelengths below 355 nm is identified. Available experimental data for infrared radiation (1.4-4 mu m) can be fitted well with an inverse-absorption curve for saline. The exposure limits roughly follow the absorption curve with a varying degree of safety scaling factor. A lack of experimental threshold data is identified for wavelengths around the 3 Am. absorption peak for water absorption. The inverse curve for the spectral absorption of water would suggest a rather low threshold for a biological effect at 3 mu m. (C) 2008 Laser Institute of America. C1 [Schulmeister, Karl] Austrian Res Ctr, A-2444 Seibersdorf, Austria. [Sliney, David H.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Mellerio, John] St Thomas Hosp, Rayne Inst, Dept Ophthalmol, London SE1 7EH, England. [Lund, David J.; Stuck, Bruce E.] US Army Med Res Detachment, Walter Reed Army Inst Res, Brooks AFB, TX 78235 USA. [Zuclich, Joseph A.] Northrop Grumman Informat Technol, San Antonio, TX 78288 USA. RP Schulmeister, K (reprint author), Austrian Res Ctr, A-2444 Seibersdorf, Austria. EM karl.schulmeister@arcs.ac.at NR 41 TC 4 Z9 6 U1 0 U2 5 PU LASER INST AMER PI ORLANDO PA 13501 INGENUITY DR, SUITE 128, ORLANDO, FL 32826 USA SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD MAY PY 2008 VL 20 IS 2 BP 98 EP 105 DI 10.2351/1.2900539 PG 8 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA 303NE UT WOS:000256046400006 ER PT J AU Dudina, DV Hulbert, DM Jiang, D Unuvar, C Cytron, SJ Mukherjee, AK AF Dudina, Dina V. Hulbert, Dustin M. Jiang, Dongtao Unuvar, Cosan Cytron, Sheldon J. Mukherjee, Amiya K. TI In situ boron carbide-titanium diboride composites prepared by mechanical milling and subsequent Spark Plasma Sintering SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID B4C-TIB2 COMPOSITES; MICROSTRUCTURE; TEMPERATURE; FRACTURE; PHASE; FIELD; ACTIVATION; TOUGHNESS; MIXTURES; DENSE AB Boron carbide - titanium diboride composites were synthesized and consolidated by Spark Plasma Sintering ( SPS) of mechanically milled elemental powder mixtures. The phase and microstructure evolution of the composites during sintering in the 1,200 - 1,700 degrees C temperature range was studied. With increasing sintering temperature, the phase formation of the samples was completed well before full density was achieved. The distribution of titanium diboride in the sintered samples was significantly improved with increasing milling time of the Ti - B - C powder mixtures. A bulk composite material of nearly full density, fine uniform microstructure, and increased fracture toughness was obtained by SPS at 1,700 degrees C. The grain size of boron carbide and titanium diboride in this material was 5 - 7 and 1 - 2 mu m, respectively. C1 [Dudina, Dina V.; Hulbert, Dustin M.; Jiang, Dongtao; Unuvar, Cosan; Mukherjee, Amiya K.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. [Cytron, Sheldon J.] USA, Res Lab, Ctr Dev & Engn, Picatinny Arsenal, NJ 07806 USA. RP Mukherjee, AK (reprint author), Univ Calif Davis, Dept Chem Engn & Mat Sci, 1 Shields Ave, Davis, CA 95616 USA. EM akmukherjee@ucdavis.edu NR 34 TC 24 Z9 26 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD MAY PY 2008 VL 43 IS 10 BP 3569 EP 3576 DI 10.1007/s10853-008-2563-8 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 288CQ UT WOS:000254964200031 ER PT J AU Croft, DT Jordan, RM Patney, HL Shriver, CD Vernalis, MN Orchard, TJ Ellsworth, DL AF Croft, Daniel T., Jr. Jordan, Rick M. Patney, Heather L. Shriver, Craig D. Vernalis, Marina N. Orchard, Trevor J. Ellsworth, Darrell L. TI Performance of whole-genome amplified DNA isolated from serum and plasma on high-density single nucleoticle polymorphism arrays SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Article ID MULTIPLE DISPLACEMENT AMPLIFICATION; GENOTYPING PERFORMANCE; WIDE ASSOCIATION; CLINICAL-SAMPLES; DEGRADED DNA; PANEL; BANK; DEGRADATION; MICROARRAYS; UTILITY AB Defining genetic variation associated with complex human diseases requires standards based on high-quality DNA from well-characterized patients. With the development of robust technologies for whole-genome amplification, sample repositories such as serum banks now represent a potentially valuable source of DNA for both genomic studies and clinical diagnostics. We assessed the performance of whole-genome amplified DNA (wgaDNA) derived from stored serum/plasma on high-density single nucleotide polymorphism arrays. Neither storage time nor usage history affected either DNA extraction or whole-genome amplification yields; however, samples that were thawed and refrozen showed significantly lower call rates (73.9 +/- 7.8%) than samples that were never thawed (92.0 +/- 3.3%) (P < 0.001). Genotype call rates did not differ significantly (P = 0.13) between wgaDNA from never-thawed serum/plasma (92.9 +/- 2.6%) and genomic DNA (97.5 +/- 0.3%) isolated from whole blood. Approximately 400,000 genotypes were consistent between wgaDNA and genomic DNA, but the overall discordance rate of 4.4 +/- 3.8% reflected an average of 11,110 +/- 9502 genotyping errors per sample. No distinct patterns of chromosomal clustering were observed for single nucleotide polymorphisms showing discordant genotypes or homozygote conversion. Because the effects of genotyping errors on whole-genome studies are not well defined, we recommend caution when applying wgaDNA from serum/plasma to high-density single nucleotide polymorphisin arrays in addition to the use of stringent quality control requirements for the resulting genotype data. C1 [Croft, Daniel T., Jr.; Jordan, Rick M.; Patney, Heather L.; Ellsworth, Darrell L.] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. [Ellsworth, Darrell L.] Windber Res Inst, Integrat Cardiac & Metab Hlth Program, Windber, PA 15963 USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Gen Surg Serv, Washington, DC 20307 USA. [Vernalis, Marina N.] Walter Reed Army Med Ctr, Integrat Cardiac Hlth Program, Washington, DC 20307 USA. [Orchard, Trevor J.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA. RP Ellsworth, DL (reprint author), Windber Res Inst, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM d.ellsworth@wriwindber.org NR 47 TC 15 Z9 15 U1 1 U2 3 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD MAY PY 2008 VL 10 IS 3 BP 249 EP 257 DI 10.2353/jmoldx.2008.070155 PG 9 WC Pathology SC Pathology GA 294YP UT WOS:000255442500009 PM 18403606 ER PT J AU Wei, G Hartings, JA Yang, XF Tortella, FC Lu, XCM AF Wei, Guo Hartings, Jed A. Yang, Xiaofang Tortella, Frank C. Lu, Xi-Chun M. TI Extraluminal cooling of bilateral common carotid arteries as a method to achieve selective brain cooling for neuroprotection SO JOURNAL OF NEUROTRAUMA LA English DT Article DE acute brain injury; common carotid arteries; hypothermia; induced; middle cerebral artery occlusion; spreading cortical depressions ID FOCAL CEREBRAL-ISCHEMIA; MODERATE HYPOTHERMIA; MILD HYPOTHERMIA; POSTTRAUMATIC HYPOTHERMIA; ACUTE STROKE; INJURY; RATS; MODEL; COAGULOPATHY; INFLAMMATION AB Systemic cooling to achieve brain hypothermia has been investigated as a neuroprotective therapy but can present serious adverse effects. Here we describe a novel method to selectively cool the rat brain and investigate its neuroprotective effects following transient middle cerebral artery occlusion (MCAo). The novelty of our method of selective brain cooling (SBC) was that the extraluminal cooling of the carotid arterial blood was achieved by using a cooling cuff wrapped around each common carotid artery (CCA). Within 20 min of CCA cooling, brain temperature could be lowered by 2-5 degrees C below the baseline and maintained stable for similar to 2 h while maintaining body temperature at 37 degrees C. No adverse effects of SBC were observed on systemic physiology, regional cerebral blood flow (rCBF), bleeding time, or tissue histology in normal animals. In rats having sustained 2-h MCAo, intra-ischemic SBC for 90 min, initiated 30 min following the onset of ischemia, significantly reduced infarction measured at 24 h post-injury (normothermic rats = 312 +/- 51 mm(3), SBC rats = 139 +/- 83 mm(3)). In subgroup experiments, the incidence of peri-infarct depolarization (PID) was assessed during the MCAo and cooling period. Compared to normothermic but ischemic rats, SBC significantly reduced the number of PID events from 6.2 +/- 2.5 to 2.0 +/- 2.5, and reduced infarct volumes from 323 +/- 79 to 139 +/- 102 mm(3). In conclusion, this extralumimal cooling method of SBC provides a safe and efficient approach to rapidly and safely achieve hypothermic neuroprotection. C1 [Wei, Guo; Hartings, Jed A.; Yang, Xiaofang; Tortella, Frank C.; Lu, Xi-Chun M.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM May.Lu@us.army.mil NR 40 TC 15 Z9 16 U1 0 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD MAY PY 2008 VL 25 IS 5 BP 549 EP 559 DI 10.1089/neu.2007.0498 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 303PY UT WOS:000256054100011 PM 18435596 ER PT J AU Madigan, WP Raymond, WR Wroblewski, KJ Thebpatiphat, N Birdsong, RH Jaafar, MS AF Madigan, William P. Raymond, William R. Wroblewski, Keith J. Thebpatiphat, Nuthida Birdsong, Richard H. Jaafar, Mohamad S. TI A review of pediatric uveitis: Part I. Infectious causes and the masquerade syndromes SO JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS LA English DT Review ID ACUTE RETINAL NECROSIS; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; NECROTIZING HERPETIC RETINOPATHY; SIMPLEX-VIRUS TYPE-2; OCULAR TOXOCARIASIS; CYTOMEGALOVIRUS RETINITIS; ANTERIOR UVEITIS; POSTSTREPTOCOCCAL UVEITIS; LYME-DISEASE AB Uveitis is a manifestation of complex processes that can represent an infectious or a purely immune system modulated condition and may have grave effects on the eye. Much of the morbidity in these conditions is the result of the immune response to these stimuli. These infectious diseases may be successfully treated by addressing the inciting organism with recognized interventions. Treatment of the immune response to the organism often must be pursued simultaneously to minimize long-term complications caused by structural changes within the eye. Assisting the individual's immune response to eliminate the organism while minimizing the immune response's damaging effects remains a unique challenge drawing on both the science and the art of medicine. Several non-infectious conditions that are not autoimmune diseases may commonly masquerade as uveitis, leading to delays in appropriate treatment. C1 [Madigan, William P.; Thebpatiphat, Nuthida; Jaafar, Mohamad S.] Childrens Natl Med Ctr, Washington, DC 20011 USA. [Raymond, William R.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Wroblewski, Keith J.] NEI, NIH, Bethesda, MD 20892 USA. [Birdsong, Richard H.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Madigan, WP (reprint author), Childrens Natl Med Ctr, 111 Michigan Ave NW, Washington, DC 20011 USA. NR 117 TC 6 Z9 7 U1 0 U2 5 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0191-3913 J9 J PEDIAT OPHTH STRAB JI J. Pediatr. Ophthalmol. Strabismus. PD MAY-JUN PY 2008 VL 45 IS 3 BP 140 EP 149 PG 10 WC Ophthalmology; Pediatrics SC Ophthalmology; Pediatrics GA 301RY UT WOS:000255914500003 PM 18524191 ER PT J AU Luo, N Miley, GH Gimlin, R Burton, R Rusek, J Holcomb, F AF Luo, Nie Miley, George H. Gimlin, Richard Burton, Rodney Rusek, John Holcomb, Frank TI Hydrogen-peroxide-based fuel cells for space power systems SO JOURNAL OF PROPULSION AND POWER LA English DT Article; Proceedings Paper CT 3rd International Energy Conversion Engineering Conference and Exhibit CY AUG 15-18, 2005 CL San Francisco, CA ID 2-PHASE FLOW; CATHODE AB A fuel cell using nontraditional fuel and oxidizer is investigated in this research. H2O2 is used in this unique fuel cell directly at the cathode. Two types of reactant, namely, a gas-phase hydrogen and anaqueous NaBH4 solution,were used as fuel at the anode. The direct utilization of H2O2 and NaBH4 at the electrodes, as seen in experiments, results in >30% higher voltage output compared to the ordinary H-2/O-2 fuel cell. Further, the unique combination of NaBH4 and H2O2, both of which are in an aqueous form, has numerous advantages from an operational point of view. This design is inherently compact compared to other cells that use gas-phase reactants. Consequently, the peroxide-based fuel cell is well suited for space power applications where air is not available and a high-energy density fuel is essential. C1 [Luo, Nie; Miley, George H.] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. [Gimlin, Richard; Burton, Rodney] Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA. [Rusek, John] Swift Enterprises Ltd, W Lafayette, IN 47906 USA. [Holcomb, Frank] USA, Erdc, Champaign, IL 61822 USA. RP Luo, N (reprint author), Univ Illinois, Dept Nucl Plasma & Radiol Engn, 103 S Goodwin, Urbana, IL 61801 USA. NR 26 TC 13 Z9 13 U1 0 U2 7 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD MAY-JUN PY 2008 VL 24 IS 3 BP 583 EP 589 DI 10.2514/1.31522 PG 7 WC Engineering, Aerospace SC Engineering GA 300HN UT WOS:000255815000025 ER PT J AU Mishchenko, MI Videen, G Menguc, MP AF Mishchenko, Michael I. Videen, Gorden Menguec, M. Pinar TI The Tenth Electromagnetic and Light Scattering Conference - Preface SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Editorial Material ID NONSPHERICAL PARTICLES; SPECIAL-ISSUE; RADIATIVE-TRANSFER; INTERNATIONAL-SYMPOSIUM C1 [Mishchenko, Michael I.] NASA, Goddard Inst Space Studies, New York, NY 10025 USA. [Videen, Gorden] USA, Res Lab, AMSRD ARL CI EM, Adelphi, MD 20783 USA. [Menguec, M. Pinar] Univ Kentucky, Dept Mech Engn, Lexington, KY 40506 USA. RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. EM crmim@giss.nasa.gov RI Menguc, Pinar/O-3114-2013; Mishchenko, Michael/D-4426-2012 NR 12 TC 8 Z9 8 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAY PY 2008 VL 109 IS 8 BP 1335 EP 1337 DI 10.1016/j.jqsrt.2008.01.015 PG 3 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 296TZ UT WOS:000255570000001 ER PT J AU Kocifaj, M Videen, G AF Kocifaj, Miroslav Videen, Gorden TI Optical behavior of composite carbonaceous aerosols: DDA and EMT approaches SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 10th International Conference on Electromagnetic and Light Scattering by Non-Spherical Particles CY JUN 17-23, 2007 CL Bodrum, TURKEY DE light scattering; black carbon; composite particles; discrete dipole approximation; effective medium theory ID EFFECTIVE-MEDIUM APPROXIMATIONS; INTERSTELLAR GRAINS; LIGHT-SCATTERING; PARTICLES; RADIATION; MODELS; SPHERE; URBAN AB Atmospheric particles may contain a small amount of black carbon (BC) that may affect their optical properties. These optical properties also depend strongly on the particle morphology and internal topology. The efficiency factors for scattering Q(sca), absorption Q(abs), extinction Q(ext), backscattering Q(bk), as well as the asymmetry parameter (cos), linear polarization P, and scattering phase functions S-11 are analyzed in detail as functions of morphology and internal topology. Backscattering quantities (like Q(bk) and P and S-11 at large scattering angles) are affected most significantly. The behavior of these quantities depends strongly on the internal mixing of the constituent materials making up the particle. Effective medium theories (EMTs), which assume that the particle is homogeneous and are applied frequently in radiative transfer studies, can underestimate Q(sca) and S-11 especially when high carbon contents are considered. Contrarily, EMTs also tend to overestimate the values of the asymmetry parameter and Q(abs). (C) 2007 Elsevier Ltd. All rights reserved. C1 [Kocifaj, Miroslav] Slovak Acad Sci, Astron Inst, Bratislava 84504, Slovakia. [Videen, Gorden] USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Kocifaj, M (reprint author), Slovak Acad Sci, Astron Inst, Dubravska Cesta 9, Bratislava 84504, Slovakia. EM kocifaj@savba.sk; gvideen@arl.army.mil NR 30 TC 16 Z9 16 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAY PY 2008 VL 109 IS 8 BP 1404 EP 1416 DI 10.1016/j.jqsrt.2007.11.007 PG 13 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 296TZ UT WOS:000255570000008 ER PT J AU Mishchenko, MI Videen, G Khlebtsov, NG Wriedt, T Zakharova, NT AF Mishchenko, Michael I. Videen, Gorden Khlebtsov, Nikolai G. Wriedt, Thomas Zakharova, Nadia T. TI Comprehensive T-matrix reference database: A 2006-07 update SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 10th International Conference on Electromagnetic and Light Scattering by Non-Spherical Particles CY JUN 17-23, 2007 CL Bodrum, TURKEY DE electromagnetic scattering; T-matrix method ID ANOMALOUS DIFFRACTION APPROXIMATION; SCATTERING CROSS-SECTION; RANDOM PARTICULATE MEDIA; LIGHT-SCATTERING; NONSPHERICAL PARTICLES; MULTIPLE-SCATTERING; SATELLITE-OBSERVATIONS; RADIATIVE PROPERTIES; OPTICAL-PROPERTIES; COHERENT BACKSCATTERING AB This paper presents an update to the comprehensive database of T-matrix publications authored by us previously and mostly includes the publications that appeared since 2005. It also lists several earlier publications not included in the original database. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Mishchenko, Michael I.; Zakharova, Nadia T.] NASA, Goddard Inst Space Studies, New York, NY 10025 USA. [Videen, Gorden] USA, Res Lab, AMSRL IS EE, Adelphi, MD 20783 USA. [Khlebtsov, Nikolai G.] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, Saratov 410015, Russia. [Wriedt, Thomas] Inst Werkstofftech, D-28359 Bremen, Germany. RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. EM crmim@giss.nasa.gov RI Mishchenko, Michael/D-4426-2012; Khlebtsov, Nikolai/D-6199-2017; Pylaev, Timofey/A-8401-2016; OI Pylaev, Timofey/0000-0002-2701-3333; Khlebtsov, Nikolai/0000-0002-2055-7784 NR 127 TC 36 Z9 38 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAY PY 2008 VL 109 IS 8 BP 1447 EP 1460 DI 10.1016/j.jqsrt.2008.01.001 PG 14 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 296TZ UT WOS:000255570000012 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Draltry Shkuratov, Yurly Videen, Gorden TI Sh-matrices method applied to light scattering by finite circular cylinders SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 10th International Conference on Electromagnetic and Light Scattering by Non-Spherical Particles CY JUN 17-23, 2007 CL Bodrum, TURKEY ID PARTICLES; SPHEROIDS; CAPSULE; SIZE AB We present a rigorous analytical solution describing light scattering by a finite circular cylinder of arbitrary dimensions. This solution uses a modification of the extended boundary condition method (EBCM) that is based on the introduction of the so-called Sh-matrices. The Sh-matrices depend only on the shape of particles and do not depend on the particle size or optical constants. The Sh-matrices can be used to find the transition-matrix (T-matrix), that contains all the scattering information from the particle system. The solution is confirmed by corresponding discrete-dipole approximation (DDA) and traditional EBCM calculations. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Videen, Gorden] Army Res Lab, AMSRL CI ES, Adelphi, MD 20783 USA. [Petrov, Draltry; Shkuratov, Yurly] Karazin Natl Univ, Astron Inst Kharkov VN Karazin Natl Univ, UA-61022 Kharkov, Ukraine. RP Videen, G (reprint author), Army Res Lab, AMSRL CI ES, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM petrov@astron.kharkov.ua; gvideen@arl.army.mil NR 18 TC 13 Z9 13 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD MAY PY 2008 VL 109 IS 8 BP 1474 EP 1495 DI 10.1016/j.jqsrt.2008.01.024 PG 22 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 296TZ UT WOS:000255570000014 ER PT J AU Olague, HM Etzkorn, LH Messimer, SL Delugach, HS AF Olague, Hector M. Etzkorn, Letha H. Messimer, Sherri L. Delugach, Harry S. TI An empirical validation of object-oriented class complexity metrics and their ability to predict error-prone classes in highly iterative, or agile, software: a case study SO JOURNAL OF SOFTWARE MAINTENANCE AND EVOLUTION-RESEARCH AND PRACTICE LA English DT Article DE complexity metrics; object-oriented complexity metrics; fault proneness; object-oriented metrics; agile software development processes; empirical validation ID FAULT-PRONENESS; DESIGN AB Empirical studies have shown complexity metrics to be good predictors of testing effort and maintainability in traditional, imperative programming languages. Empirical validation studies have also shown that complexity is a good predictor of initial quality and reliability in object-oriented (OO) software. To date, one of the most empirically validated OO complexity metrics is the Chidamber and Kemerer Weighted Methods in a Class (WMC). However, there are many more OO complexity metrics whose predictive power has not been as extensively explored. In this study, we explore the predictive ability of several complexity-related metrics for OO software that have not been heavily validated. We do this by exploring their ability to measure quality in an evolutionary software process, by correlating these metrics to defect data for six versions of Rhino, an open-source implementation of JavaScript written in Java. Using statistical techniques such as Spearman's correlation, principal component analysis, binary logistic regression models and their respective validations, we show that some lesser known complexity metrics including Michura et al.'s standard deviation method complexity and Etzkorn et al.'s average method complexity are more consistent predictors of OO quality than any variant of the Chidamber and Kemerer WMC metric. We also show that these metrics are useful in identifying fault-prone classes in software developed using highly iterative or agile software development processes. Copyright (c) 2008 John Wiley & Sons, Ltd. C1 [Olague, Hector M.] USA, Space & Missile Def Command, Huntsville, AL USA. [Olague, Hector M.; Etzkorn, Letha H.; Delugach, Harry S.] Univ Alabama, Dept Comp Sci, Huntsville, AL 35899 USA. [Messimer, Sherri L.] Univ Alabama, Dept Ind & Syst Engn, Huntsville, AL 35899 USA. RP Olague, HM (reprint author), USA, Space & Missile Def Command, POB 1500, Huntsville, AL USA. EM holague@cs.uah.edu NR 34 TC 10 Z9 11 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1532-060X EI 2047-7481 J9 J SOFTW MAINT EVOL-R JI J. Softw. Maint. Evol.-Res. Pract. PD MAY-JUN PY 2008 VL 20 IS 3 BP 171 EP 197 DI 10.1002/smr.366 PG 27 WC Computer Science, Software Engineering SC Computer Science GA 320JK UT WOS:000257229300001 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI A soldier to the last: Maj. Gen. Joseph Wheeler in blue and gray SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Washington, DC 20310 USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSOC PI ATHENS PA UNIV GEORGIA, HISTORY DEPT, ATHENS, GA 30602 USA SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD MAY PY 2008 VL 74 IS 2 BP 460 EP 461 PG 2 WC History SC History GA 292UN UT WOS:000255291700033 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Major general Isaac Ridgeway trimble: Biography of a Baltimore confederate SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Washington, DC 20310 USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSOC PI ATHENS PA UNIV GEORGIA, HISTORY DEPT, ATHENS, GA 30602 USA SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD MAY PY 2008 VL 74 IS 2 BP 460 EP 461 PG 2 WC History SC History GA 292UN UT WOS:000255291700034 ER PT J AU Silton, SI Massey, KC AF Silton, Sidra I. Massey, Kevin C. TI Investigation of actuator performance for guiding supersonic projectiles SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article; Proceedings Paper CT AIAA 22nd Applied Aerodynamics Conference CY AUG 16-19, 2004 CL Providence, RI SP AIAA AB A recent study showed that the complex three-dimensional shock/boundary-layer interaction of a pin placed next to a fin produces an asymmetric lift force that can be used for flight control of a projectile. The current study was completed to validate this new technology. A similar projectile was modeled, using high-performance fluid dynamic computations and 6 degree-of-freedom trajectory simulations, to determine the projectile's flight characteristics before being flown in the U.S. Army Research Laboratory's Aerodynamic Experimental Facility. A flight test was designed using this asymmetric lift to produce roll torque. Analysis of the flight data determined that the projectiles with pins developed the expected rolling moments. Computations were completed after the range test on the experimental model for computational validation. C1 [Silton, Sidra I.] USA, Res Lab, Aerodynam Branch, Ballist & Weap Concepts Div,Weap & Mat Res Direct, Aberdeen Proving Ground, MD 21005 USA. [Massey, Kevin C.] Georgia Tech Res Inst, Aerosp Transportat & Adv Syst Lab, Smyrna, GA 30080 USA. RP Silton, SI (reprint author), USA, Res Lab, Aerodynam Branch, Ballist & Weap Concepts Div,Weap & Mat Res Direct, Mail Stop AMSRD-ARL-WM-BC, Aberdeen Proving Ground, MD 21005 USA. NR 12 TC 2 Z9 2 U1 3 U2 6 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAY-JUN PY 2008 VL 45 IS 3 BP 504 EP 510 DI 10.2514/1.34014 PG 7 WC Engineering, Aerospace SC Engineering GA 312SG UT WOS:000256690500010 ER PT J AU Tong, MS Chew, WC White, MJ AF Tong, Mei Song Chew, Weng Cho White, Michael J. TI Multilevel fast multipole algorithm for acoustic wave scattering by truncated ground with trenches SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID BOUNDARY-ELEMENT METHOD; SOUND FIELD ANALYSIS; INTEGRAL-EQUATIONS; ELECTROMAGNETIC SCATTERING; PARTICLE SIMULATIONS; NUMERICAL-SOLUTION; NYSTROM SCHEME; RAPID SOLUTION; SINGULARITY; FORMULATION AB The multilevel fast multipole algorithm (MLFMA) is extended to solve for acoustic wave scattering by very large objects with three-dimensional arbitrary shapes. Although the fast multipole method as the prototype of MLFMA was introduced to acoustics early, it has not been used to study acoustic problems with millions of unknowns. In this work, the MLFMA is applied to analyze the acoustic behavior for very large truncated ground with many trenches in order to investigate the approach for mitigating gun blast noise at proving grounds. The implementation of the MLFMA is based on the Nystrom method to create matrix equations for the acoustic boundary integral equation. As the Nystrom method has a simpler mechanism in the generation of far-interaction terms, which MLFMA acts on, the resulting scheme is more efficient than those based on the method of moments and the boundary element method (BEM). For near-interaction terms, the singular or near-singular integrals are evaluated using a robust technique, which differs from that in BEM. Due to the enhanced efficiency, the MLFMA can rapidly solve acoustic wave scattering problems with more than two million unknowns on workstations without involving parallel algorithms. Numerical examples are used to demonstrate the performance of the MLFMA with report of consumed CPU time and memory usage. (c) 2008 Acoustical Society of America. C1 [Tong, Mei Song; Chew, Weng Cho] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. [White, Michael J.] USA Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Tong, MS (reprint author), Univ Illinois, Dept Elect & Comp Engn, 1406 W Green St, Urbana, IL 61801 USA. EM meisongt@uiuc.edu RI Chew, Weng Cho/C-1792-2009; White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 NR 42 TC 10 Z9 10 U1 0 U2 1 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 2008 VL 123 IS 5 BP 2513 EP 2521 DI 10.1121/1.2897048 PN 1 PG 9 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 301FE UT WOS:000255881000009 PM 18529170 ER PT J AU Ferguson, JL Hennion, DR AF Ferguson, Jason L. Hennion, Duane R. TI Portal vein thrombosis: An unexpected finding in a 28-year-old male with abdominal pain SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Article ID RECURRENT VENOUS THROMBOEMBOLISM; PROTHROMBIN GENE MUTATION; FACTOR-V-LEIDEN; G20210A MUTATION; HETEROZYGOUS CARRIERS; ANTICOAGULANT-THERAPY; RISK-FACTORS; THROMBOPHILIA; MANAGEMENT; ADULTS AB Background: Abdominal pain is a common primary care complaint. Portal vein thrombosis (PVT) is a rare cause of abdominal pain, typically associated with cirrhosis or thrombophilia. The following describes the presentation of PVT in a young male, the search for risk factors and underlying etiology, and the debate of anticoagulation therapy. Case: A 28-year-old male presented with periumbilical pain, post-prandial nausea, and sporadic hematemesis for 3 weeks. The diagnosis was confirmed with a triphasic liver computerized tomography after obtaining an abnormal right upper quadrant ultrasound. This unexpected finding prompted investigation for intrinsic hepatic disease and potential hypercoagulable disorders. Laboratory analysis revealed a heterozygous genotype for the prothrombin 20210G/A mutation, an identified risk factor for venous thrombosis. Discussion: Recommendations concerning anticoagulation for PVT in the absence of cirrhosis are not clearly defined. Current literature describes the following factors as indications for anticoagulation: acute thrombus, lack of cavernous transformation, absence of esophageal varices, and mesenteric venous thrombosis. This patient had clinical indications both for and against anticoagulation. Weighing this individual's clinical circumstances, we concluded the risk of thrombus in the setting of a hypercoagulable disorder outweighed the risk of variceal bleeding. A minimum of 6 months of anticoagulation was initiated. Conclusion: PVT is an uncommon cause of abdominal pain, and the absence of hepatic disease should raise the index of suspicion for an underlying thrombophilia. Specific recommendations for anticoagulation are not well defined, demonstrating the importance of weighing the individual risks and benefits in treatment with anticoagulation for young persons with thrombophilia. C1 [Ferguson, Jason L.; Hennion, Duane R.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. RP Ferguson, JL (reprint author), Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. EM jjferg23@yahoo.com NR 38 TC 4 Z9 5 U1 0 U2 1 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD MAY-JUN PY 2008 VL 21 IS 3 BP 237 EP 243 DI 10.3122/jabfm.2008.03.070157 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 299EG UT WOS:000255738000010 PM 18467536 ER PT J AU Boddu, VM Viswanath, DS Maloney, SW AF Boddu, Veera M. Viswanath, Dabir S. Maloney, Stephen W. TI Synthesis and characterization of coralline magnesium oxide nanoparticles SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID H-1 MAS NMR; SURFACE; MGO; ADSORPTION; PARTICLES/CLUSTERS; CHEMISORPTION; SPECTROSCOPY; POWDERS; XRD AB Magnesium oxide (MgO) nanoparticles were prepared using sol-gel process. The nanoparticles were then dried using a supercritical drying process. The particles were characterized for surface morphology, crystal structure, and surface functionality. The nanoparticles show a coralline structure with an average particle size of 200-300 nm with a surface area of 257 m(2)/g. The X-ray diffraction spectra of these materials are also obtained. The MgO particles, when contacted with a model explosive component 2, 4 dinitrotoluene in water at 50 degrees C, showed a concentration reduction of 96%. C1 [Boddu, Veera M.; Maloney, Stephen W.] USA, Construct Engn Res Lab, Engn Res & Dev Ctr, Environm Proc Branch, Champaign, IL 61824 USA. [Viswanath, Dabir S.] Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO USA. RP Boddu, VM (reprint author), USA, Construct Engn Res Lab, Engn Res & Dev Ctr, Environm Proc Branch, Champaign, IL 61824 USA. EM Veera.Boddu@usace.army.mil NR 23 TC 10 Z9 10 U1 0 U2 3 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD MAY PY 2008 VL 91 IS 5 BP 1718 EP 1720 DI 10.1111/j.1551-2916.2008.02344.x PG 3 WC Materials Science, Ceramics SC Materials Science GA 297ZR UT WOS:000255656400056 ER PT J AU Kheirabadi, BS Crissey, JM Deguzman, R Perez, MR Cox, AB Dubick, MA Holcomb, JB AF Kheirabadi, Bijan S. Crissey, Jacqueline M. Deguzman, Rodolfo Perez, Michael R. Cox, Ashley B. Dubick, Michael A. Holcomb, John B. TI Effects of synthetic versus natural colloid resuscitation on inducing dilutional coagulopathy and increasing hemorrhage in rabbits SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 66th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 27-29, 2007 CL Las Vegas, NV SP Amer Assoc Surg Trauma DE hemostasis; dilutional; coagulopathy; 5% albumin; hextend; dextran 70; splenic hemorrhage; rabbit ID VITRO THROMBELASTOGRAPHY MEASUREMENTS; HYDROXYETHYL STARCH 6-PERCENT; LACTATED RINGERS SOLUTION; CRITICALLY-ILL PATIENTS; VIVO BLEEDING-TIME; IN-VITRO; FLUID RESUSCITATION; BLOOD-COAGULATION; CARDIOPULMONARY BYPASS; ALBUMIN RESUSCITATION AB Background. On the basis of logistic benefits of colloids over crystalloids, the U.S. military selected Hextend for resuscitation of combat casualties in the field. We investigated the effects of resuscitation with this fluid, as well as other colloids, on coagulation and uncontrolled bleeding in rabbits subjected to a splenic injury. Methods. Anesthetized male New Zealand white rabbits (33 kg +/- 0.2 kg) were divided into three groups and subjected to hypothermia (35 degrees C +/- 0.5 degrees C) and similar to 40% isovolemic blood exchange (hemodilution) with Hextend (M; Dextran70 (D); or 5% human albumin (A) solution (n = 8/group). Complete blood count, arterial blood gas, and coagulation values were measured before and after hemodilution. Laparotomy was performed and a standard splenic injury causing uncontrolled hemorrhage was made. Rabbits were resuscitated (25 mL/kg) with the same colloid used for hemodilution to restore baseline blood pressure. Animals were monitored for 2 hours or until death. Blood loss and survival times were measured. Results. There were no differences among groups in pH, Hct, fibrinogen, or platelets before or after hemodilution. Hct, fibrinogen, and platelets were reduced by 45% to 60% in all groups. Prothrombin time (PT) and activated partial thromboplastin time were prolonged in all the rabbits with the greatest increase in A group. Thrombelastograph (TEG) analysis showed longer initial reaction (R) and clotting (K) times, slower clotting rate and lower clot strength in H and D than A diluted blood. R time was faster and K time remained unchanged in A group after hemodilution. Thrombin generation potential and peak concentration of thrombin were unchanged in A samples but significantly reduced in H and D diluted samples. Subsequent splenic injury led to almost equal blood losses (similar to 54 +/- 1 mL/kg) in H and D groups, which were higher (p < 0.01) than in A rabbits (37 +/- 4 mL/kg). This resulted in death of 100% (H), 75% (D), and 50% (A) of the rabbits with significant difference in survival time among the groups. Conclusion: TEG and thrombin generation assays identified more severe coagulopathy development with H and D than A dilution, whereas plasma PT and activated partial thromboplastin time measurements did not differentiate between these colloids. These results suggest that resuscitation with albumin maintained coagulation function, decreased blood loss, and improved survival time compared with the synthetic colloids. C1 [Kheirabadi, Bijan S.; Crissey, Jacqueline M.; Deguzman, Rodolfo; Perez, Michael R.; Cox, Ashley B.; Dubick, Michael A.; Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kheirabadi, BS (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM bijan.kheirabadi@cen.amedd.army.mil NR 68 TC 28 Z9 30 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2008 VL 64 IS 5 BP 1218 EP 1228 DI 10.1097/TA.0b013e31816c5c6c PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 301SH UT WOS:000255915400015 PM 18469644 ER PT J AU Rice, J Philbin, N Light, R Arnaud, F Steinbach, T McGwin, G Collier, S Malkevich, N Moon-Massatt, P Rentko, V Pearce, LB Ahlers, S McCarron, R Handrigan, M Freilich, D AF Rice, Jennifer Philbin, Nora Light, Rick Arnaud, Francoise Steinbach, Thomas McGwin, Gerry Collier, Sarah Malkevich, Nina Moon-Massatt, Paula Rentko, Virginia Pearce, L. Bruce Ahlers, Stephen McCarron, Richard Handrigan, Michael Freilich, Daniel TI The effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers in swine with hemorrhagic shock SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE hemoglobin-based oxygen carrier; tetrameric hemoglobin; hemorrhage; swine; vasoactivity; blood pressure ID CROSS-LINKED HEMOGLOBIN; BOVINE POLYMERIZED HEMOGLOBIN; CELL-FREE HEMOGLOBIN; TARGETED O-2 DELIVERY; NITRIC-OXIDE; DELAYED EVACUATION; BLOOD SUBSTITUTE; LIVER-INJURY; VASCULAR-RESPONSE; HETASTARCH HEX AB Background: Some hemoglobin-based oxygen carriers (HBOCs) improve outcome in animal models of hemorrhagic shock (HS) in comparison with standard asanguinous resuscitation fluids. Nevertheless, concern about intrinsic vasoactivity, linked in part to low-molecular weight (MW) hemoglobin (Hb), has slowed HBOC development. We assessed the impact of decreasing the low-MW Hb component of bovine HBOC on vasoactivity in severe HS. Methods: Anesthetized invasively monitored swine were hemorrhaged 55% blood volume and resuscitated with bovine HBOC containing 31% (31 TD [HBOC-301]),2% (2 TD [HBOC-201]), or 0.4% (0.4 TD) low-MW Hb. Pigs received four 10 mL/kg infusions over 60 minutes, hospital arrival was simulated at 75 minutes, organ blood flow (BF) was evaluated by microsphere injection, and monitoring was continued for 4 hours followed by complete necrotic evaluation. Results: . There were few differences between 2 TD and 0.4 TD. Thirty-one TD pigs had higher systemic and pulmonary blood pressure (BP), systemic vascular resistance index, and pulmonary artery wedge pressure, compared with 2 TD or 0.4 TD (p < 0.01); however, pigs in all groups had at least mildly elevated BP. Transcutaneous tissue oxygenation, base excess, and mixed venous oxygen saturation were similar across groups; lactate and methemoglobin were highest with 0.4 TD (p < 0.03). There were no group differences in BE Over time, myocardial BF increased and hepatic BF decreased in all groups (for 31 TD, p < 0.05); renal BF was unchanged in all groups. There were no group differences in heart, lung, or liver histopathology, and survival. Conclusions: Although purification from 31% to 2 % low-MW Rb content significantly decreased vasoactive responses, further purification to 0.4% had no additional clinically measurable effects in severe HS. If further diminution in HBOC vasoactivity is desired for use in HS, additional technical approaches may be required. C1 [Rice, Jennifer; Philbin, Nora; Arnaud, Francoise; Collier, Sarah; Malkevich, Nina; Ahlers, Stephen; McCarron, Richard; Handrigan, Michael; Freilich, Daniel] USN, Med Res Ctr, Silver Spring, MD 20910 USA. [Light, Rick; Moon-Massatt, Paula; Rentko, Virginia; Pearce, L. Bruce] Biopure Corp, Cambridge, MA USA. [Steinbach, Thomas] Walter Reed Army Inst Res, Silver Spring, MD USA. [McGwin, Gerry] Univ Alabama, Birmingham, AL USA. RP Freilich, D (reprint author), USN, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM daniel.freilich@med.navy.mil NR 49 TC 19 Z9 19 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2008 VL 64 IS 5 BP 1240 EP 1257 DI 10.1097/TA.0013618058245e PG 18 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 301SH UT WOS:000255915400019 PM 18469646 ER PT J AU Svoboda, SJ Owens, BD Gooden, HA Melvin, ML Baer, DG Wenke, JC AF Svoboda, Steven J. Owens, Brett D. Gooden, Heather A. Melvin, Michael L. Baer, David G. Wenke, Joseph C. TI Irrigation with potable water versus normal saline in a contaminated musculoskeletal wound model SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE irrigation; contamination; infection; wound management ID TAP WATER AB Background: Although the use of potable water for wound irrigation is attractive in an austere environment, its effectiveness has not been tested. We sought to compare the effectiveness of potable water irrigation in reducing bacterial number with that of normal saline irrigation. Methods: We used an established caprine model involving the creation of a reproducible complex musculoskeletal wound followed by inoculation with luminescent bacteria that allowed for quantitative analysis with a photon-counting camera system. Six hours after injury and inoculation, wound irrigations were performed using pulsatile lavage. Fourteen goats were randomized into two treatment groups: irrigation with 9 L potable water versus irrigation with 9 L normal saline. Images obtained after irrigation were compared with baseline images to determine the reduction in bacterial luminescence resulting from treatment. Results: The irrigation in both groups reduced the bacterial counts by 71% from the preirrigation levels. Conclusion: Potable water reduced the bacterial load as effectively as normal saline in our model. C1 [Svoboda, Steven J.; Owens, Brett D.; Gooden, Heather A.; Melvin, Michael L.; Baer, David G.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Wenke, JC (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Rd, Ft Sam Houston, TX 78234 USA. EM joseph.wenke@us.army.mil NR 11 TC 19 Z9 20 U1 4 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2008 VL 64 IS 5 BP 1357 EP 1359 DI 10.1097/TA.0b013e31816e3476 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 301SH UT WOS:000255915400035 PM 18469661 ER PT J AU DeCastro, BJ Costabile, RA MeMann, LP Peterson, AC AF DeCastro, Brian J. Costabile, Raymond A. MeMann, Leah P. Peterson, Andrew C. TI Oral ketoconazole for prevention of postoperative penile erection: A placebo controlled, randomized, double-blind trial SO JOURNAL OF UROLOGY LA English DT Article DE ketoconazole; penile erection; pain ID METASTATIC PROSTATE-CANCER; HIGH-DOSE KETOCONAZOLE; PRECOCIOUS PUBERTY; MANAGEMENT; THERAPY; BIOSYNTHESIS; INHIBITION; BEHAVIOR AB Purpose: Patients undergoing penile surgery often have postoperative erections that can be painful and may interfere with wound healing. In retrospective studies ketoconazole has been shown to decrease the number and pain of postoperative erections. We conducted a prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of ketoconazole in the prevention of postoperative erections. Materials and Methods: Patients undergoing penile reconstructive surgery were randomized to receive ketoconazole (400 mg 3 times a day) or placebo starting 2 days before surgery and continuing for 7 days after surgery. We recorded the number and characteristics of each erection on a standardized log. Liver function tests were drawn before and after surgery. Results: Of the 40 patients enrolled 20 were randomized to the ketoconazole group and 20 to placebo. In the ketoconazole group 81.25% reported postoperative erections compared to 83% in the placebo group. Of those patients who had postoperative erections 85% in the ketoconazole group reported painful erections compared to 80% in the placebo group. These differences were not statistically significant (p >0.99). In the ketoconazole group 3 patients (15.8%) withdrew early because of nausea and 1 in the ketoconazole group had a transient increase in liver function tests. Conclusions: To our knowledge this is the only prospective, double-blind, placebo controlled study to evaluate the use of ketoconazole in the prevention of postoperative erections. While prior retrospective reports showed promise for this medication, our study suggests that ketoconazole is not effective in preventing postoperative erections. C1 [DeCastro, Brian J.; Peterson, Andrew C.] Madigan Army Med Ctr, Dept Surg, Urol Serv, Tacoma, WA 98431 USA. [Costabile, Raymond A.] Univ Virginia, Sch Med, Dept Urol, Charlottesville, VA 22908 USA. [MeMann, Leah P.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Peterson, AC (reprint author), Madigan Army Med Ctr, Dept Surg, Urol Serv, 1 Fitzimmons Dr, Tacoma, WA 98431 USA. EM andrew.peterson@amedd.army.mil NR 20 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 2008 VL 179 IS 5 BP 1930 EP 1932 DI 10.1016/j.juro.2008.01.039 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 288SE UT WOS:000255005300074 PM 18353393 ER PT J AU Moul, JW Wu, HY Sun, L McLeod, DG Amling, C Donahue, T Kusuda, L Sexton, W O'Reilly, K Hernandez, J Chung, A Soderdahl, D AF Moul, Judd W. Wu, Hongyu Sun, Leon McLeod, David G. Amling, Christopher Donahue, Timothy Kusuda, Leo Sexton, Wade O'Reilly, Keith Hernandez, Javier Chung, Andrew Soderdahl, Douglas TI Early versus delayed hormonal therapy for prostate specific antigen only recurrence of prostate cancer after radical prostatectomy (Reprinted from The Journal of Urology, vol 171, pg 1141-1147, 2004) SO JOURNAL OF UROLOGY LA English DT Reprint DE prostatic neoplasms; recurrence; prostate-specific antigen; hormones; prostatectomy ID ANDROGEN SUPPRESSION; DEFENSE CENTER; PSA; PROGRESSION; DATABASE; ERA AB Purpose: Hormonal therapy (HT) is the current mainstay of systemic treatment for prostate specific antigen (PSA) only recurrence (PSAR), however, there is virtually no published literature comparing HT to observation in the clinical setting. The goal of this study was to examine the Department of Defense Center for Prostate Disease Research observational database to compare clinical outcomes in men who experienced PSAR after radical prostatectomy by early versus delayed use of HT and by a risk stratified approach. Materials and Methods: Of 5,382 men in the database who underwent primary radical prostatectomy (RP), 4,967 patients were treated in the PSA-era between 1988 and December 2002. Of those patients 1,352 men who had PSAR (PSA after surgery greater than 0.2 ng/ml) and had postoperative followup greater than 6 months were used as the study cohort. These patients were further divided into an early HT group in which patients (355) received HT after PSA only recurrence but before clinical metastasis and a late HT group for patients (997) who received no HT before clinical metastasis or by current followup. The primary end point was the development of clinical metastases. Of the 1,352 patients with PSAR clinical metastases developed in 103 (7.6%). Patients were also stratified by surgical Gleason sum, PSA doubling time and timing of recurrence. Univariate and multivariate Cox proportional hazard models were used to evaluate the effect of early and late HT on clinical outcome. Results: Early HT was associated with delayed clinical metastasis in patients with a pathological Gleason sum greater than 7 or PSA doubling time of 12 months or less (Hazards ratio = 2.12, p = 0.01). However, in the overall cohort early HT did not impact clinical metastases. Race, age at RP and PSA at diagnosis had no effect on metastasis-free survival (p >0.05). Conclusions: The retrospective observational multicenter database analysis demonstrated that early HT administered for PSAR after prior RP was an independent predictor of delayed clinical metastases only for high-risk cases at the current followup. Further study with longer followup and randomized trials are needed to address this important issue. C1 [Moul, Judd W.; Wu, Hongyu; Sun, Leon] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD 20852 USA. [Donahue, Timothy] Natl Naval Med Ctr, Dept Urol, Bethesda, MD USA. [Chung, Andrew] Malcolm Grow Med Ctr, Dept Urol, Andrews AFB, MD USA. [Moul, Judd W.; McLeod, David G.] Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. [Amling, Christopher] San Diego Naval Med Ctr, Dept Urol, San Diego, CA USA. [Kusuda, Leo] Portsmouth Naval Med Ctr, Dept Urol, Portsmouth, VA USA. [Sexton, Wade] Wilford Hall USAF Med Ctr, Dept Urol, Lackland AFB, TX 78236 USA. [Hernandez, Javier] Brooke Army Med Ctr, Dept Surg, Urol Serv, San Antonio, TX USA. [O'Reilly, Keith] Madigan Army Med Ctr, Dept Surg, Urol Serv, Tacoma, WA 98431 USA. [Soderdahl, Douglas] Eisenhower Army Med Ctr, Dept Surg, Urol Serv, Augusta, GA USA. RP Moul, JW (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, 1530 E Jefferson St, Rockville, MD 20852 USA. EM jmoul@cpdr.org NR 21 TC 12 Z9 14 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 2008 VL 179 IS 5 SU S BP S53 EP S59 DI 10.1016/j.juro.2008.03.138 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 288SG UT WOS:000255005500019 PM 18405753 ER PT J AU Younossi, ZM Nader, FH Bai, C Sjogren, R Ong, JP Collantes, R Sjogren, M Farmer, D Ramsey, L Terra, K Gujral, H Gurung, C Srishord, M Fang, Y AF Younossi, Z. M. Nader, F. H. Bai, C. Sjogren, R. Ong, J. P. Collantes, R. Sjogren, M. Farmer, D. Ramsey, L. Terra, K. Gujral, H. Gurung, C. Srishord, M. Fang, Y. TI A phase II dose finding study of darbepoetin alpha and filgrastim for the management of anaemia and neutropenia in chronic hepatitis C treatment SO JOURNAL OF VIRAL HEPATITIS LA English DT Article DE darbepoetin alpha and filgrastim; growth factors; HCV ID QUALITY-OF-LIFE; INTERFERON-ALPHA-2B PLUS RIBAVIRIN; HCV-INFECTED PATIENTS; COMBINATION THERAPY; PEGINTERFERON ALPHA-2A; VIRUS-INFECTION; IMPACT; TRIAL AB Dose reductions of pegylated interferon alpha and ribavirin may be avoided by using growth factors. This phase II clinical trial assesses the dose, efficacy and safety of darbepoetin alpha and filgrastim for treatment of anaemia and neutropenia associated with combination therapy for hepatitis C virus (HCV). Chronic hepatitis C patients (n = 101) received pegylated interferon alpha-2b (1.5 mu g/kg once weekly) and ribavirin (800-1400 mg once daily). Patients with anaemia [haemoglobin (Hb) <= 10.5 g/dL] received darbepoetin alpha (3 mu g/kg once every 2 weeks); the dose was titrated to achieve a Hb level of 12.0 g/dL. Patients with neutropenia [absolute neutrophil count (ANC) <= 0.75 x 10(9)/L] received filgrastim with the dose titrated from 150 mu g QW to 300 mu g thrice weekly to maintain ANC >= 0.75 x 10(9)/L and < 10 x 10(9)/L. During antiviral therapy, 52% of patients required darbepoetin alpha, filgrastim or both. Hb at the time of darbepoetin alpha initiation was 10.2 +/- 0.4 g/dL. After 81 days of darbepoetin alpha, Hb increased by 1.9 +/- 1.0 g/dL to 12.1 +/- 1.1 g/dL (P < 0.0001). Filgrastim resulted in a significant increase in ANC [0.75 +/- 0.16 x 109/L to 8.28 +/- 5.67 x 10(9)/L (P < 0.0001)]. In treatment-naive patients, 48% achieved sustained virological response (SVR), whereas 27% of patients previously treated with a course of pegylated interferon alpha achieved SVR. Low viral load, nongenotype 1 and treatment with growth factors were independently associated with SVR. Mild and severe anaemia were associated with quality of life impairments. Darbepoetin alpha resulted in an improvement in the Vitality domain of Short Form-36. No significant adverse events were related to growth factors. During anti-HCV therapy, filgrastim improved neutropenia and darbepoetin alpha improved both anaemia and quality of life. Future randomized clinical trials are needed to establish the impact of growth factors in improving sustained virological response. C1 [Younossi, Z. M.; Nader, F. H.; Bai, C.; Ong, J. P.; Collantes, R.; Farmer, D.; Ramsey, L.; Terra, K.; Gujral, H.; Gurung, C.; Srishord, M.; Fang, Y.] Inova Fairfax Hosp, Ctr Liver Dis, Annandale, VA 22003 USA. [Sjogren, R.] Kaiser Permanente Med Grp, Falls Church, VA USA. [Sjogren, M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Younossi, ZM (reprint author), Inova Fairfax Hosp, Ctr Liver Dis, 3289 Woodburn Rd,Suite 375, Annandale, VA 22003 USA. EM zobair.younossi@inova.com NR 21 TC 26 Z9 27 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1352-0504 J9 J VIRAL HEPATITIS JI J. Viral Hepatitis PD MAY PY 2008 VL 15 IS 5 BP 370 EP 378 DI 10.1111/j.1365-2893.2007.00956.x PG 9 WC Gastroenterology & Hepatology; Infectious Diseases; Virology SC Gastroenterology & Hepatology; Infectious Diseases; Virology GA 282JH UT WOS:000254563200007 PM 18194172 ER PT J AU Retta, SM Sagripanti, JL AF Retta, S. M. Sagripanti, J. -L. TI Modeling the inactivation kinetics of bacillus spores by glutaraldehyde SO LETTERS IN APPLIED MICROBIOLOGY LA English DT Article DE bacillus; decontamination; disinfection; glutaraldehyde; spore ID FLEXIBLE ENDOSCOPY; APIC GUIDELINE; INFECTION PREVENTION; DISINFECTION; CHLORINE; DEMAND; WATER AB Aims: Our goal was to develop a mathematical kinetic model to predict the sporicidal activity of glutaraldehyde, which is an active ingredient frequently used in commercial products employed for liquid disinfection and decontamination. Methods and Results: We used our previously published data on spore inactivation by glutaraldehyde to develop a predictive model obtained by calculating multiple independent modifying functions. The model was then validated by comparing model predicted values to new experimental data. For model validation, quality-controlled spores of Bacillus athrophaeus (previously and generally known as Bacillus subtilis globigii) were exposed under conditions where several physicochemical variables were modified simultaneously, and the spore surviving fractions were measured by titration. Conclusions: The model predicted within one order of magnitude variations in sporicidal effectiveness due to changes in main parameters (glutaraldehyde concentration, temperature or time-duration of the treatment). Other parameters such pH, salinity and the effect of serum concentration were also addressed, albeit with less accuracy. Significance and Impact of the study: The model should be useful to quantitatively estimate the effectiveness of glutaraldehyde-based disinfectants, decontaminants, and germicides under the described conditions, particularly when limited data are available or when spore virulence (like that of Bacillus anthracis) precludes extensive experimentation. A similar approach could predict the effectiveness of a variety of decontaminant and disinfecting agents. C1 [Sagripanti, J. -L.] USA, AMSRD ECB RT, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Retta, S. M.] Food Drug Adm, Ctr Devices & Radiol Hlth, Div Solid & Fluid Mech, Silver Spring, MD USA. RP Sagripanti, JL (reprint author), USA, AMSRD ECB RT, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd,Edgewood Area, Aberdeen Proving Ground, MD 21010 USA. EM joseluis.sagripanti@us.army.mil NR 32 TC 2 Z9 3 U1 0 U2 6 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0266-8254 J9 LETT APPL MICROBIOL JI Lett. Appl. Microbiol. PD MAY PY 2008 VL 46 IS 5 BP 568 EP 574 DI 10.1111/j.1472-765X.2008.02358.x PG 7 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 288MY UT WOS:000254991700011 PM 18397220 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Wisconsin Korean war stories: Veterans tell their stories from the forgotten war SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 1 PY 2008 VL 133 IS 8 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 293TY UT WOS:000255359400127 ER PT J AU Hartzell, JD Wood-Morris, RN Martinez, LJ Trottta, RF AF Hartzell, Joshua D. Wood-Morris, Robert N. Martinez, Luis J. Trottta, Richard F. TI Q fever: Epidemiology, diagnosis, and treatment SO MAYO CLINIC PROCEEDINGS LA English DT Review ID COXIELLA-BURNETII; UNITED-STATES; ENDOCARDITIS; THERAPY; ANTIBIOTICS; INFECTION AB Q fever, a zoonosis caused by Coxiella burnetii, is seen throughout the world. Recent reports suggest that its incidence in the United States is increasing, with more than 30 cases reported in the US military. The disease has many acute and chronic manifestations. Endocarditis is the most common form of chronic disease, and recent studies have led to substantial changes in the approach to its diagnosis and treatment. Military and civilian health care professionals need to consider Q fever when evaluating patients with appropriate geographic exposures and clinical presentations to prevent delays in diagnosis and treatment. C1 Walter Reed Army Med Ctr, Infect Dis Serv, Dept Internal Med, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Hartzell, JD (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, Dept Internal Med, BLD 2,Ward 63,6900 Georgia Ave NW, Washington, DC 20307 USA. EM joshua.hartzell@na.amedd.army.mil NR 30 TC 54 Z9 65 U1 2 U2 4 PU MAYO CLINIC PROCEEDINGS PI ROCHESTER PA 660 SIEBENS BLDG MAYO CLINIC, ROCHESTER, MN 55905 USA SN 0025-6196 J9 MAYO CLIN PROC JI Mayo Clin. Proc. PD MAY PY 2008 VL 83 IS 5 BP 574 EP 579 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 297EX UT WOS:000255601000013 PM 18452690 ER PT J AU Stulz, DA AF Stulz, Dean A. TI Combating Heat Injury in Desert Wars SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Stulz, Dean A.] USA, Ft Hood, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP 61 EP 61 DI 10.1249/01.mss.0000321239.28174.1c PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070900014 ER PT J AU Chinevere, TD Kenefick, RW Cheuvront, SN Lukaski, HC Sawka, MN AF Chinevere, Troy D. Kenefick, Robert W. Cheuvront, Samuel N. Lukaski, Henry C. Sawka, Michael N. TI Effect of heat acclimation on sweat minerals SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE calcium; copper; iron; magnesium; zinc ID PROLONGED EXERCISE; TRACE-METALS; WHOLE-BODY; SODIUM; IRON; ZINC; LOSSES; REQUIREMENTS; ALDOSTERONE; RESPONSES AB Purpose: This study examined the impact of 10 d of exercise-heat acclimation on sweat mineral concentrations. Methods: Eight male subjects walked on a treadmill at 3.5 mph, 4% grade for 100 continuous minutes or until rectal temperature reached 39.5 degrees C on 10 consecutive days in an environmental chamber set at 45 degrees C, 20% relative humidity. Arm sweat samples were collected during the first 30 min of exercise-heat stress on days 1 and 10 using a polyethylene arm glove. Results: Final core temperature and HR values were significantly lower (P < 0.05) on day 10 versus day 1. Whole-body sweating rates increased by approximately 6% (P=0.12). Sweat sodium concentration on day 10 (36.22 +/- 7.22 mM) was significantly lower than day 1 (54.49 +/- 16.18 mM) (P < 0.05). Sweat mineral concentrations of calcium (similar to 29%), copper (similar to 50%), and magnesium (similar to 43%) were also significantly lower on day 10 versus day 1 of heat acclimation (P < 0.05). A trend for lower sweat iron (similar to 75%; P=0.07) and zinc (similar to 23%; P=0.10) concentrations were observed from day 1 to day 10. The estimated hourly sweat mineral losses (arm concentration x whole-body sweat rate) were reduced for calcium (similar to 27%), copper (similar to 46%), and magnesium (similar to 42%) (P < 0.05), but not iron (75%) or zinc (similar to 16%) (P > 0.05), from day 1 to day 10. Conclusion: Exercise-heat acclimation conserves arm sweat mineral concentrations and possibly whole-body sweat losses of calcium, copper, and magnesium, and may reduce sweat iron and zinc concentrations. C1 [Chinevere, Troy D.; Kenefick, Robert W.; Cheuvront, Samuel N.; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Lukaski, Henry C.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA. RP Chinevere, TD (reprint author), USA, Environm Med Res Inst, Bldg 42,Kansas St, Natick, MA 01760 USA. EM Troy.Chinevere@us.anny.mil NR 39 TC 25 Z9 26 U1 2 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 BP 886 EP 891 DI 10.1249/MSS.0b013e3181641c04 PG 6 WC Sport Sciences SC Sport Sciences GA 292AH UT WOS:000255238200015 PM 18408609 ER PT J AU Abe, T Brechue, WF Fujita, S Ogasawara, R Yasuda, T Sato, Y AF Abe, Takashi Brechue, William F. Fujita, Satoshi Ogasawara, Riki Yasuda, Tomohiro Sato, Yoshiaki TI Muscle Hypertrophy following Multi-joint Low Intensity Resistance Training with Single-joint Blood Flow Restriction SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Abe, Takashi; Fujita, Satoshi; Ogasawara, Riki; Yasuda, Tomohiro; Sato, Yoshiaki] Univ Tokyo, Kashiwa, Chiba, Japan. [Brechue, William F.] US Mil Acad, W Pint, NY USA. EM abe@k.u-tokyo.ac.jp NR 0 TC 1 Z9 1 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S257 EP S257 DI 10.1249/01.mss.0000322413.61086.1a PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902354 ER PT J AU Alemany, JA Frystyk, J Tuckow, AP Spiering, BA Hatfield, DL Staab, JS Chen, JW Flyvbjerg, A Maresh, CM Kraemer, WJ Nindl, BC AF Alemany, Joseph A. Frystyk, Jan Tuckow, Alexander P. Spiering, Barry A. Hatfield, Disa L. Staab, Jeffery S. Chen, Jian-Wen Flyvbjerg, Allen Maresh, Carl M. Kraemer, William J. Nindl, Bradley C. TI Effects Of Resistance, Aerobic And Combined Exercise Training On Immunoreactive Vs. Bioassayable IGF-I SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Alemany, Joseph A.; Tuckow, Alexander P.; Staab, Jeffery S.; Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Frystyk, Jan; Chen, Jian-Wen; Flyvbjerg, Allen] Aarhus Univ Hosp, DK-8000 Aarhus, Denmark. [Spiering, Barry A.; Hatfield, Disa L.; Maresh, Carl M.; Kraemer, William J.] Univ Connecticut, Storrs, CT USA. EM joseph.alemany@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S105 EP S105 DI 10.1249/01.mss.0000321905.63045.93 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901404 ER PT J AU Antczak, AJ Brininger, TL AF Antczak, Amanda J. Brininger, Teresa L. TI Quantification of Eating Disorders among Female Army Soldiers by Medical Diagnosis SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Antczak, Amanda J.; Brininger, Teresa L.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM amanda.antczak@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S53 EP S53 DI 10.1249/01.mss.0000321678.08779.1d PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901205 ER PT J AU Bliss, MV Bellar, D Kamimori, GH Glickman, EL Barkley, JE Ryan, EJ Bellar, A AF Bliss, Matthew V. Bellar, David Kamimori, Gary H. Glickman, Ellen L. Barkley, Jacob E. Ryan, Edward J. Bellar, Ann TI The Effect of Caffeine Supplementation on Performance in the Standing Shot Put Throw SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Bliss, Matthew V.; Bellar, David; Glickman, Ellen L.; Barkley, Jacob E.; Ryan, Edward J.] Kent State Univ, Kent, OH 44242 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bellar, Ann] Wayne State Univ, Detroit, MI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S362 EP S362 DI 10.1249/01.mss.0000323448.37371.3f PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070903128 ER PT J AU Catrambone, DE Young, AJ Scrimgeour, AG AF Catrambone, Daniel E. Young, Andrew J. Scrimgeour, Angus G. TI Effects of Moderate Zinc Deficiency and Phytase Supplementation on Musculoskeletal Integrity in Exercising Rats SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Catrambone, Daniel E.; Young, Andrew J.; Scrimgeour, Angus G.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM daniel.catrambone@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S341 EP S341 DI 10.1249/01.mss.0000323365.23978.45 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070903045 ER PT J AU Crowder, TA Leth, AD Fenske, BD Park, R Bryan, JW AF Crowder, Todd A. Leth, Allen D. Fenske, Brad D. Park, Ronnie Bryan, Joshua W. TI A "Field-Expedient" Upper Body Muscular Strength-Endurance Assessment Which Mitigates Body Mass Influence in College-Age Men SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Crowder, Todd A.; Leth, Allen D.; Fenske, Brad D.; Park, Ronnie; Bryan, Joshua W.] US Mil Acad, West Point, NY 10996 USA. EM todd.crowder@usma.edu NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S427 EP S427 DI 10.1249/01.mss.0000322817.99208.6c PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070903396 ER PT J AU DeGroot, DW Goodman, DA Montain, SJ Cheuvront, SN AF DeGroot, David W. Goodman, Daniel A. Montain, Scott J. Cheuvront, Samuel N. TI Validation of the ICDA Model for Predicting Body Core Temperature SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [DeGroot, David W.; Goodman, Daniel A.; Montain, Scott J.; Cheuvront, Samuel N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM david.degroot@amedd.army.mil RI DeGroot, David/E-2322-2015 NR 0 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S367 EP S367 DI 10.1249/01.mss.0000323468.95680.57 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070903148 ER PT J AU Duffey, MJ Duffey, ML Vargas, D Cameron, K Mountcastle, S Nelson, BJ AF Duffey, Michael J. Duffey, Michele L. Vargas, Donna Cameron, Kenneth Mountcastle, Sally Nelson, Bradley J. TI How a Movement Training Program Affects Jump Landing Mechanics and ACL Injury Risk SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Duffey, Michael J.; Duffey, Michele L.] Penn State Univ, University Pk, PA 16802 USA. [Vargas, Donna; Cameron, Kenneth] Keller Army Hosp, West Point, NY USA. [Mountcastle, Sally] Univ Texas El Paso, El Paso, TX 79968 USA. [Nelson, Bradley J.] Univ Minnesota, Minneapolis, MN USA. EM mjd277@psu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S167 EP S167 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901613 ER PT J AU Farnell, G Pierce, K Demes, R Collinsworth, T Ryan, EJ Bellar, D Bliss, MV Barkley, JE Kamimori, GH Glickman, EL AF Farnell, Greg Pierce, Katherine Demes, Rob Collinsworth, Tiffany Ryan, Edward J. Bellar, David Bliss, Matthew V. Barkley, Jacob E. Kamimori, Gary H. Glickman, Ellen L. TI Effects of Body Composition on Thermoregulatory Responses During Cold Water Immersion in Healthy Males SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Farnell, Greg] Univ Cent Oklahoma, Edmond, OK USA. [Pierce, Katherine; Demes, Rob; Collinsworth, Tiffany; Ryan, Edward J.; Bellar, David; Bliss, Matthew V.; Barkley, Jacob E.; Glickman, Ellen L.] Kent State Univ, Kent, OH 44242 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S228 EP S228 DI 10.1249/01.mss.0000322480.49791.c3 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902239 ER PT J AU Fettrow, L Bellar, D Kamimori, GH Glickman, EL Barkley, JE Ryan, EJ Bliss, MV Bellar, A AF Fettrow, Liz Bellar, David Kamimori, Gary H. Glickman, Ellen L. Barkley, Jacob E. Ryan, Edward J. Bliss, Matthew V. Bellar, Ann TI The Effects of Caffeine on Reaction Time as shown in the Standing Shot Put Throw SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Fettrow, Liz; Bellar, David; Glickman, Ellen L.; Barkley, Jacob E.; Ryan, Edward J.; Bliss, Matthew V.] Kent State Univ, Kent, OH 44242 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bellar, Ann] Wayne State Univ, Detroit, MI USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S361 EP S362 DI 10.1249/01.mss.0000323447.37371.db PG 2 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070903127 ER PT J AU Freeman, CN Romero, SA Rickards, CA Ryan, KL Lurie, KG Convertino, VA Cooke, WH AF Freeman, Christine N. Romero, Steven A. Rickards, Caroline A. Ryan, Kathy L. Lurie, Keith G. Convertino, Victor A. Cooke, William H. TI Inspiratory Resistance Increases Cerebral Blood Velocity Oscillations During Standing After Exercise SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Freeman, Christine N.; Romero, Steven A.; Cooke, William H.] Univ Texas San Antonio, San Antonio, TX USA. [Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Lurie, Keith G.] Univ Minnesota, Minneapolis, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S286 EP S286 DI 10.1249/01.mss.0000323158.66532.3d PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902469 ER PT J AU Fulco, CS Muza, SR Beidleman, B Jones, J Lammi, E Kambis, K Doan, BK Brothers, MD Zupan, MF Cymerman, A AF Fulco, Charles S. Muza, Stephen R. Beidleman, Beth Jones, Juli Lammi, Eric Kambis, Kenneth Doan, Brandon K. Brothers, Michael D. Zupan, Michael F. Cymerman, Allen TI Living For Six Days At 2200 M Improves Prolonged Time-Trial Performance Of Sea-Level Residents Exposed To 4300 M SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Fulco, Charles S.; Muza, Stephen R.; Beidleman, Beth; Jones, Juli; Lammi, Eric; Kambis, Kenneth; Cymerman, Allen] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Doan, Brandon K.; Brothers, Michael D.] USAF Acad, Colorado Springs, CO 80840 USA. [Zupan, Michael F.] AF Res Lab, Brooks City Base, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S171 EP S172 DI 10.1249/01.mss.0000322209.91131.79 PG 2 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902012 ER PT J AU Goodman, DA Diaz, J Cadarette, BS Ely, BR Kenefick, RW Cheuvront, SN AF Goodman, Daniel A. Diaz, Jorge Cadarette, Bruce S. Ely, Brett R. Kenefick, Robert W. Cheuvront, Samuel N. TI Ingestible Telemetry Core Temperature Sensor Measurements Are Affected By Gastrointestinal Tract Location SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Goodman, Daniel A.; Diaz, Jorge; Cadarette, Bruce S.; Ely, Brett R.; Kenefick, Robert W.; Cheuvront, Samuel N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM daniel.a.goodman@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S366 EP S366 DI 10.1249/01.mss.0000323466.49939.ee PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070903146 ER PT J AU Gregory, RW AF Gregory, Robert W. TI Sense of Effort During Unilateral and Bilateral Finger Force Production SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Gregory, Robert W.] US Mil Acad, West Point, NY 10996 USA. EM robert.gregory@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S444 EP S444 DI 10.1249/01.mss.0000322888.56045.dc PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070903467 ER PT J AU Grier, T Knapik, JJ Canada, S Canham-Chervak, M Jones, BH AF Grier, Tyson Knapik, Joseph J. Canada, Sara Canham-Chervak, Michelle Jones, Bruce H. TI Risk Factors Associated with Self-Reported Training-Related Injury at the US Army Ordnance School SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Grier, Tyson; Knapik, Joseph J.; Canada, Sara; Canham-Chervak, Michelle; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S235 EP S235 DI 10.1249/01.mss.0000322508.02195.63 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902267 ER PT J AU Harvey, T Broderick, K Brechue, WF AF Harvey, Travis Broderick, Kevin Brechue, William F. TI Pull-up Performance Poorly Related To Measures Of Chest And Back Maximal Strength SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Harvey, Travis; Broderick, Kevin; Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. EM Travis.Harvey@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S262 EP S262 DI 10.1249/01.mss.0000322430.23614.a4 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902371 ER PT J AU Hauret, KG Canada, S Canham-Chervak, M Jones, BH Strauss, W AF Hauret, Keith G. Canada, Sara Canham-Chervak, Michelle Jones, Bruce H. Strauss, Warren TI Predictors of Injury in US Army Basic Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Hauret, Keith G.; Canada, Sara; Canham-Chervak, Michelle; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Strauss, Warren] Battelle Mem Inst, Columbus, OH 43201 USA. EM keith.hauret@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S235 EP S236 DI 10.1249/01.mss.0000322509.79323.01 PG 2 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902268 ER PT J AU John, EB Mukherjee, M Kim, SH Liu, W Gregory, RW AF John, Emmanuel B. Mukherjee, Mukul Kim, Seok H. Liu, Wen Gregory, Robert W. TI A Quantitative Method for Assessing Stroke-impaired Sense of Motor Effort: A Preliminary Study SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [John, Emmanuel B.] Howard Univ, Washington, DC 20059 USA. [Mukherjee, Mukul; Kim, Seok H.; Liu, Wen] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA. [Gregory, Robert W.] US Mil Acad, West Point, NY 10996 USA. EM ebjohn@howard.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S318 EP S318 DI 10.1249/01.mss.0000323231.26930.cb PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902601 ER PT J AU Kane, SF Cohen, MI Pennardt, AM Anderson, SE AF Kane, Shawn F. Cohen, Michael I. Pennardt, Andre M. Anderson, Steve E. TI Spinal Cord Injury - Military Free Fall (MFF) Parachuting SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Kane, Shawn F.; Cohen, Michael I.; Pennardt, Andre M.; Anderson, Steve E.] Womack Army Med Ctr, Ft Bragg, NC USA. EM shawn.kane@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S151 EP S151 DI 10.1249/01.mss.0000322120.36522.d5 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901557 ER PT J AU Kenefick, RW Palombo, LJ Riel, NA Cheuvront, SN Castellani, JW AF Kenefick, Robert W. Palombo, Laura J. Riel, Nathan A. Cheuvront, Samuel N. Castellani, John W. TI Effect of Varying Osmolality on Vasoconstriction and Skin Temperature during Whole Body Cold Exposure SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Kenefick, Robert W.; Palombo, Laura J.; Cheuvront, Samuel N.; Castellani, John W.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Riel, Nathan A.] Univ New Hampshire, Durham, NH 03824 USA. EM Robert.Kenefick@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S230 EP S230 DI 10.1249/01.mss.0000322486.87909.73 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902245 ER PT J AU Knapik, JJ Darakjy, S Swedler, D Hauret, KG Amoroso, P Jones, BH AF Knapik, Joseph J. Darakjy, Salima Swedler, David Hauret, Keith G. Amoroso, Paul Jones, Bruce H. TI Injury Prevention Effectiveness of The Parachute Ankle Brace after Controlling for Extrinsic Risk Factors SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Knapik, Joseph J.; Darakjy, Salima; Swedler, David; Hauret, Keith G.; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Amoroso, Paul] Madigan Army Med Ctr, Tacoma, WA 98431 USA. EM joseph.knapik@apg.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S235 EP S235 DI 10.1249/01.mss.0000322506.94571.b1 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902265 ER PT J AU Lorenz, MC Subudhi, AW Fulco, CS Roach, RC AF Lorenz, Matthew C. Subudhi, Andrew W. Fulco, Charles S. Roach, Robert C. TI Cerebrovascular Responses To Incremental Exercise During Hypobaric Hypoxia: Effect Of Oxygenation On Maximal Performance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Lorenz, Matthew C.; Subudhi, Andrew W.; Roach, Robert C.] Univ Colorado, Altitude Res Ctr, Aurora, CO USA. [Lorenz, Matthew C.; Subudhi, Andrew W.; Roach, Robert C.] Univ Colorado, Altitude Res Ctr, Colorado Springs, CO 80907 USA. [Fulco, Charles S.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM mlorenz@uccs.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S51 EP S52 DI 10.1249/01.mss.0000321670.01155.eb PG 2 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901198 ER PT J AU Meyering, C AF Meyering, Christopher TI Persistent Lower Leg Pain Recalcitrant to Treatment SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Meyering, Christopher] DD Eisenhower Family Med Residency, Ft Gordon, GA USA. EM christopher.meyering@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S145 EP S145 DI 10.1249/01.mss.0000322093.28005.a1 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901539 ER PT J AU Moore, NA Devaney, JM Hoffman, E Zambraski, E Gordish, H Clarkson, PM AF Moore, Nina A. Devaney, Joseph M. Hoffman, Eric Zambraski, Edward Gordish, Heather Clarkson, Priscilla M. TI Association Of Akt2 Genotypes And Exercise Muscle Damage SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Moore, Nina A.; Clarkson, Priscilla M.] Univ Massachusetts, Amherst, MA 01003 USA. [Devaney, Joseph M.; Hoffman, Eric; Gordish, Heather] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Zambraski, Edward] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM camoore@kin.umass.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S32 EP S32 DI 10.1249/01.mss.0000321585.05071.e7 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901123 ER PT J AU Moran, DS Evans, RK Constantini, N Hadid, A Erlich, T Laor, A Yanovich, R AF Moran, Daniel S. Evans, Rachel K. Constantini, Naama Hadid, Amir Erlich, Tomer Laor, Arie Yanovich, Ran TI Prediction Model for Stress Fracture in Young Female Recruits during Basic Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Moran, Daniel S.; Constantini, Naama; Hadid, Amir; Erlich, Tomer; Laor, Arie; Yanovich, Ran] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM dmoran@sheba.health.gov.il NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S314 EP S314 DI 10.1249/01.mss.0000323213.71779.9c PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902583 ER PT J AU Muza, S Fulco, C Beidleman, B Jones, J Staab, J Elliott, S Lammi, E Cymerman, A AF Muza, Stephen Fulco, Charles Beidleman, Beth Jones, Juli Staab, Janet Elliott, Sarah Lammi, Eric Cymerman, Allen TI Lowlander Time-Trial Performance At 4300m Is Not Improved Following Normobaric Intermittent Hypoxic Exposure Conditioning SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Muza, Stephen; Fulco, Charles; Beidleman, Beth; Jones, Juli; Staab, Janet; Elliott, Sarah; Lammi, Eric; Cymerman, Allen] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM stephen.muza@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S169 EP S169 DI 10.1249/01.mss.0000322199.81722.7a PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902002 ER PT J AU Nindl, BC Alemany, JA Pierce, JR Rarick, KR Tuckow, AP Staab, JS Harman, EA Khsoravi, J AF Nindl, Bradley C. Alemany, Joseph A. Pierce, Joseph R. Rarick, Kevin R. Tuckow, Alexander P. Staab, Jeffery S. Harman, Everett A. Khsoravi, Javad TI The Effects Of Acute And Chronic Exercise Training On IGFBP-3 Proteolysis SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Nindl, Bradley C.; Alemany, Joseph A.; Pierce, Joseph R.; Rarick, Kevin R.; Tuckow, Alexander P.; Staab, Jeffery S.; Harman, Everett A.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Khsoravi, Javad] Mt Sinai Hosp, DSL Canada Lab, Toronto, ON M5G 1X5, Canada. EM bradley.nindl@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S105 EP S105 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901406 ER PT J AU Pierce, JR Urso, ML Alemany, JA Harman, EA Nindl, BC AF Pierce, Joseph R. Urso, Maria L. Alemany, Joseph A. Harman, Everett A. Nindl, Bradley C. TI Matrix Metalloproteinase-3 And-9 Responses To Acute Heavy Resistance Exercise Are Dependent On The Mode Of Chronic Exercise Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Pierce, Joseph R.; Urso, Maria L.; Alemany, Joseph A.; Harman, Everett A.; Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM joseph.pierce@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S83 EP S83 DI 10.1249/01.mss.0000321807.07209.0d PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901319 ER PT J AU Pierce, K Farnell, G Demes, R Ryan, EJ Collinsworth, T Bellar, D Bliss, MV Barkley, JE Kamimori, GH Glickman, EL AF Pierce, Katherine Farnell, Greg Demes, Rob Ryan, Edward J. Collinsworth, Tiffany Bellar, David Bliss, Matthew V. Barkley, Jacob E. Kamimori, Gary H. Glickman, Ellen L. TI Effect of Body Composition on Epinephrine and Norepinephrine Levels During Immersion in 18, 22 and 26 degrees C Water SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Pierce, Katherine; Farnell, Greg; Demes, Rob; Ryan, Edward J.; Collinsworth, Tiffany; Bellar, David; Bliss, Matthew V.; Barkley, Jacob E.; Glickman, Ellen L.] Kent State Univ, Kent, OH 44242 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S228 EP S228 DI 10.1249/01.mss.0000322481.57414.d2 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902240 ER PT J AU Sharp, MA Knapik, JJ Walker, LA Frykman, PN Burrell, L Darakjy, S Lester, M Marin, R AF Sharp, Marilyn A. Knapik, Joseph J. Walker, Leila A. Frykman, Peter N. Burrell, Lolita Darakjy, Salima Lester, Mark Marin, Roberto TI Effects of 9-months Deployment to Afghanistan on Soldier Physical Fitness and Body Composition SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Sharp, Marilyn A.; Walker, Leila A.; Frykman, Peter N.; Lester, Mark] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Knapik, Joseph J.; Darakjy, Salima] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Burrell, Lolita] USA, Mil Acad, West Point, NY USA. [Marin, Roberto] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. EM marilyn.sharp@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S160 EP S160 DI 10.1249/01.mss.0000322159.22519.76 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901585 ER PT J AU Smith, TJ Montain, SJ McClung, J Anderson, D Stavinoha, T Young, AJ AF Smith, Tracey J. Montain, Scott J. McClung, James Anderson, Danielle Stavinoha, Trisha Young, Andrew J. TI Milk Protein Type Does Not Impact Plasma Amino Acid Concentration When Incorporated Into a High Carbohydrate Beverage SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Smith, Tracey J.; Montain, Scott J.; McClung, James; Stavinoha, Trisha; Young, Andrew J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Anderson, Danielle] Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. EM tracey.j.smith@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S101 EP S101 DI 10.1249/01.mss.0000321890.92647.20 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901391 ER PT J AU Spiering, BA Kraemer, WJ Anderson, JM Armstrong, LE Nindl, BC Volek, JS Judelson, DA Joseph, M Vingren, JL Hatfield, DL Fragala, MS Ho, JY Maresh, CM AF Spiering, Barry A. Kraemer, William J. Anderson, Jeffrey M. Armstrong, Lawrence E. Nindl, Bradley C. Volek, Jeff S. Judelson, Daniel A. Joseph, Michael Vingren, Jakob L. Hatfield, Disa L. Fragala, Maren S. Ho, Jen-Yu Maresh, Carl M. TI Importance of Elevated Circulating Hormones in Modulating Resistance Exercise-Induced Protein Kinase B Signaling in Fasted Men SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Spiering, Barry A.; Kraemer, William J.; Anderson, Jeffrey M.; Armstrong, Lawrence E.; Volek, Jeff S.; Joseph, Michael; Vingren, Jakob L.; Hatfield, Disa L.; Fragala, Maren S.; Ho, Jen-Yu; Maresh, Carl M.] Univ Connecticut, Storrs, CT USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Judelson, Daniel A.] Calif State Univ Fullerton, Fullerton, CA 92634 USA. EM Barry.Spiering-1@nasa.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S294 EP S294 DI 10.1249/01.mss.0000323490.73703.0d PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070902500 ER PT J AU Stulz, DA Rosales, JA Sipe, WC AF Stulz, Dean A. Rosales, Jason A. Sipe, William C. TI Combating Heat Injury in Desert Wars SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Stulz, Dean A.; Rosales, Jason A.; Sipe, William C.] USA, Ft Hood, TX USA. EM dean.stulz@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S46 EP S46 DI 10.1249/01.mss.0000321645.69219.a5 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901176 ER PT J AU Yasuda, T Abe, T Kurano, M Takano, H Meguro, K Brechue, WF Morita, T Sato, Y Nakajima, T AF Yasuda, Tomohiro Abe, Takashi Kurano, Miwa Takano, Haruhito Meguro, Kentaro Brechue, William F. Morita, Toshihiro Sato, Yoshiaki Nakajima, Toshiaki TI Venous Blood Changes with Low-Intensity Muscle Contractions and Blood Flow Restriction SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Yasuda, Tomohiro; Kurano, Miwa; Takano, Haruhito; Meguro, Kentaro; Morita, Toshihiro; Sato, Yoshiaki; Nakajima, Toshiaki] Univ Tokyo, Tokyo, Japan. [Abe, Takashi] Univ Tokyo, Kashiwa, Chiba, Japan. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. EM yasuda-tomohiro@umin.ac.jp NR 0 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S350 EP S350 DI 10.1249/01.mss.0000323401.47673.32 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070903081 ER PT J AU Zupan, MF Doan, BK Brothers, MD Cavallo, M Fernandez, M Fulco, CS AF Zupan, Michael F. Doan, Brandon K. Brothers, Michael D. Cavallo, Michael Fernandez, Miquel Fulco, Charles S. TI Effects of Staging at 2200 m on Eye-Hand Speed and Accuracy of Sea-Level Residents Exposed to 4300 m SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Zupan, Michael F.] USAF, Res Lab, Brooks City Base, TX USA. [Doan, Brandon K.; Brothers, Michael D.] USAF Acad, Colorado Springs, CO 80840 USA. [Cavallo, Michael; Fernandez, Miquel; Fulco, Charles S.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM michael.zupan@us.af.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2008 VL 40 IS 5 SU S BP S52 EP S52 DI 10.1249/01.mss.0000321671.01155.a2 PG 1 WC Sport Sciences SC Sport Sciences GA V19KI UT WOS:000208070901199 ER PT J AU Tou, JC Foley, A Yuan, YV Arnaud, S Wade, CE Brown, M AF Tou, Janet C. Foley, Andrea Yuan, Yvonne V. Arnaud, Sara Wade, Charles E. Brown, Marybeth TI The effect of ovariectomy combined with hindlimb unloading and reloading on the long bones of mature Sprague-Dawley rats SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY LA English DT Article DE estrogen; mechanical unloading; tibia; femur; bone biomechanics ID FEMALE RATS; PHYSICAL-ACTIVITY; BED REST; POSTMENOPAUSAL WOMEN; CANCELLOUS BONE; BODY-WEIGHT; EXERCISE; SUSPENSION; MODEL; MASS AB Objective: To determine the effect of loss of ovarian function and mechanical loading (ie, inactivity) alone or in combination on bone mass and strength. Design: Mature (aged 6 mo) rats were ovariectomized to induce loss of ovarian function and bone. Hindlimb unloading (HLU) was used to determine the effect of mechanical unloading and reloading on bone mass and strength. Bone mass of the femur and tibia was determined using dual-energy x-ray absorptiometry. Femoral and tibial bone strength was determined by a three-point bending test and by a torsion test. Results: Ovariectomy (OVX) alone decreased total bone mineral density (BMD) in the femur (-5.5%, P = 0.03) and tibia (-7.3%, P = 0.01) compared with that for sham-operated animals. HLU alone for 4 weeks had no significant effect on bone. Together OVX/HLU accentuated BMD loss in the femur (-10. 5%, P < 0.0 1) compared with that for sham-operated animals. The femur was more sensitive than the tibia to the combination of OVX/HLU, indicated by the reduction (-5.3%, P < 0.05) of total BMD below that achieved by OVX alone. Torsion tests showed that OVX/HLU but not OVX or HLU alone reduced bone strength. There was a correlation between lower femoral total BMD (r(2) = 0.65, P < 0.001) and reduced torque strength. Bone loss did not continue during the 2 weeks of reloading. Conclusions: OVX accompanied by mechanical unloading results in more rapid and severe bone loss than either OVX or unloading alone and therefore is associated with a greater likelihood of osteoporosis. C1 [Tou, Janet C.] W Virginia Univ, Div Anim & Nutr Sci, Morgantown, WV 26506 USA. [Brown, Marybeth] Univ Missouri, Dept Phys Therapy, Columbia, MO USA. [Brown, Marybeth] Univ Missouri, Ctr Gender Physiol, Columbia, MO USA. [Yuan, Yvonne V.] Ryerson Univ, Sch Nutr, Toronto, ON, Canada. [Arnaud, Sara] NASA, Ames Res Ctr, Div Life Sci, Moffett Field, CA 94035 USA. [Wade, Charles E.] USA, Inst Surg Res, Houston, TX USA. RP Tou, JC (reprint author), W Virginia Univ, Div Anim & Nutr Sci, Morgantown, WV 26506 USA. EM janet.tou@mail.wvu.edu FU NIA NIH HHS [AG15796] NR 36 TC 13 Z9 15 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1072-3714 J9 MENOPAUSE JI Menopause-J. N. Am. Menopause Soc. PD MAY-JUN PY 2008 VL 15 IS 3 BP 494 EP 502 DI 10.1097/gme.0b013e318148bbad PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 298MU UT WOS:000255692600017 PM 18030174 ER PT J AU Wright, KM Adler, AB Bliese, PD Eckford, RD AF Wright, Kathleen M. Adler, Amy B. Bliese, Paul D. Eckford, Rachel D. TI Structured clinical interview guide for postdeployment psychological screening programs SO MILITARY MEDICINE LA English DT Article ID MENTAL-HEALTH PROBLEMS; DSM-IV; MILITARY; SOLDIERS; IRAQ; SURVEILLANCE; AFGHANISTAN; VALIDATION; DEPLOYMENT; VERSION AB Brief structured clinical interviews are a key component of the Department of Defense postdeployment health reassessment program. Such interviews are critical for recommending individuals for follow-up assessment and care. To standardize the interview process, U.S. Army Medical Research Unit-Europe developed a structured interview guide, designed in response to both clinical requirements and research findings. The guide includes sections on depression, suicidality, post-traumatic stress disorder, anger, relationship problems, alcohol problems, and sleep problems. In addition, there is an open-ended section on other problems and a section for case dispositions. Data from a 2005 blinded validation study with soldiers returning from a 1-year-long combat deployment are included to demonstrate the utility of the structured interview. Guidelines and implementation considerations for the use of the structured interview are discussed. C1 [Wright, Kathleen M.; Adler, Amy B.; Bliese, Paul D.; Eckford, Rachel D.] USA, Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany. RP Wright, KM (reprint author), USA, Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany. NR 31 TC 14 Z9 15 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2008 VL 173 IS 5 BP 411 EP 421 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 300SY UT WOS:000255846700005 PM 18543560 ER PT J AU Pica-Branco, D Hudak, RP AF Pica-Branco, Denise Hudak, Ronald P. TI US military service members' perceptions of the Anthrax Vaccine Immunization Program SO MILITARY MEDICINE LA English DT Article AB This research identifies the perceptions of U.S. military service members regarding the Department of Defense Anthrax Vaccine Immunization Program (AVIP). The service members' perceptions were addressed in the dimensions of ethics, effectiveness, and safety, as well as the overall perceptions of the AVIP. The study, conducted in October 2004, randomly selected active duty service members from the uniformed services assigned to a Caribbean military base who participated in the AVIP during the period of 1998 to 2000. Their perceptions were measured with a survey instrument with 14 closed-ended, Likert-scale questions. The research demonstrated that a substantial number of service members disagreed with issues regarding the ethics, safety, and efficacy of the AVIP. We recommend enhanced training and education to increase understanding of the benefits of the AVIP. C1 [Pica-Branco, Denise] US FDA, Ctr Drug Evaluat & Res, Off Pediat & Maternal Hlth, Silver Spring, MD 20993 USA. [Hudak, Ronald P.] USA, Wounded Warrior Program, Alexandria, VA 22332 USA. RP Pica-Branco, D (reprint author), US FDA, Ctr Drug Evaluat & Res, Off Pediat & Maternal Hlth, Silver Spring, MD 20993 USA. NR 11 TC 7 Z9 7 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2008 VL 173 IS 5 BP 429 EP 433 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 300SY UT WOS:000255846700007 PM 18543562 ER PT J AU Mitchener, TA Hauret, KG Hoedebecke, EL Darakjy, S Jones, BH AF Mitchener, Timothy A. Hauret, Keith G. Hoedebecke, Edward L. Darakjy, Salima Jones, Bruce H. TI Air medical evacuations of soldiers due to oral-facial disease and injuries, Operations Enduring Freedom/Iraqi Freedom SO MILITARY MEDICINE LA English DT Article ID DENTAL EMERGENCY RATES; PERSONNEL; VIETNAM; BOSNIA AB This retrospective study was conducted to assess the nature and causes of serious oral-facial illnesses and injuries among U.S. Army personnel deployed to Iraq and Afghanistan in 2003 and 2004. Information for this study came from the U.S. Air Force Transportation Regulating and Command & Control Evacuation System database for medical evacuations (MEDEVACS) for 2003 to 2004. The study found 327 oral-facial MEDEVACS out of Iraq (cumulative incidence: 11/10,000 soldiers per year) and 47 out of Afghanistan (cumulative incidence: 21/10,000 soldiers per year), for a total of 374 MEDEVACS. Forty-two percent (n = 158) of all oral-facial MEDEVACS were due to diseases of the oral cavity, salivary glands, and jaw. Another 36% (n = 136) of oral-facial MEDEVACS were for battle injuries, primarily fractures of the mandible, caused by acts of war. Twenty-one percent (n = 80) of oral-facial MEDEVACS were due to nonbattle injuries, primarily fractures of the mandible, mainly caused by motor vehicle accidents and fighting. C1 [Mitchener, Timothy A.; Hauret, Keith G.; Hoedebecke, Edward L.; Darakjy, Salima; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. RP Mitchener, TA (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. NR 18 TC 5 Z9 6 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2008 VL 173 IS 5 BP 465 EP 473 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 300SY UT WOS:000255846700013 PM 18543568 ER PT J AU Prior, RM Marble, WS AF Prior, Richard M. Marble, William Sanders TI The overlooked heroines: Three Silver Star nurses of World War I SO MILITARY MEDICINE LA English DT Article AB As members of forward-deployed combat hospitals, World War I Army nurses Miss Jane Rignel, Miss Linnie Leckrone, and Miss Irene Robar received the Citation Star for gallantry in attending to the wounded while under artillery fire in the month of July 1918. In 1932, they were authorized to exchange their Citation Stars for the new Silver Star Medal. Nursing in the war was difficult and required caring for patients exposed to chemical weapons and trauma while in harsh field conditions. These women were among the many Army nurses decorated for their performance in World War I. C1 [Prior, Richard M.; Marble, William Sanders] USA, Off Med Hist, Off Surg Gen, Falls Church, VA 22041 USA. RP Prior, RM (reprint author), USA, Off Med Hist, Off Surg Gen, 5111 Leesburg Pike,Suite 401-B, Falls Church, VA 22041 USA. NR 15 TC 0 Z9 0 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2008 VL 173 IS 5 BP 493 EP 498 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 300SY UT WOS:000255846700017 PM 18543572 ER PT J AU Curtis, CE Barnes, EV Dupiche, CA AF Curtis, Christopher E. Barnes, Edward V. Dupiche, Christine A. TI Guillain-Barre syndrome variant: Presenting with myalgias and acute facial diplegia SO MILITARY MEDICINE LA English DT Article AB A patient with no significant medical history presented with myalgias, lower extremity weakness, and facial diplegia. Upon review of systems, the patient denied any other problems. Physical examination results were remarkable for weakness in the right leg and bilateral facial diplegia. Radiological and laboratory studies were unremarkable. Lumbar puncture revealed albuminocytological dissociation. The combined history, physical examination, and lumbar puncture results established a presumptive diagnosis of Guillain-Barre syndrome. The patient began a 5-day course of intravenous immunoglobulin therapy. At the end of the 5-day course, the patient had recovered 85% of her facial muscle function and experienced complete relief of her myalgias. Upon discharge, the patient was referred to physical therapy for improvement of her facial muscle impairment. C1 [Curtis, Christopher E.; Barnes, Edward V.; Dupiche, Christine A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Curtis, CE (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 6 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2008 VL 173 IS 5 BP 507 EP 508 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 300SY UT WOS:000255846700019 PM 18543574 ER PT J AU Lindsay, DL Barr, KR Lance, RF Tweddale, SA Hayden, TJ Leberg, PL AF Lindsay, Denise L. Barr, Kelly R. Lance, Richard F. Tweddale, Scott A. Hayden, Timothy J. Leberg, Paul L. TI Habitat fragmentation and genetic diversity of an endangered, migratory songbird, the golden-cheeked warbler (Dendroica chrysoparia) SO MOLECULAR ECOLOGY LA English DT Article DE connectivity; genetic distance; habitat specialist; microsatellite; passerine; population structure ID ALLELE FREQUENCY DATA; PARTIAL MANTEL TESTS; POPULATION-STRUCTURE; MICROSATELLITE DNA; FOREST BIRDS; EMPIRICAL-EVALUATION; TEMPERATE FOREST; YELLOW WARBLER; LANDSCAPE; DIFFERENTIATION AB Landscape genetic approaches offer the promise of increasing our understanding of the influence of habitat features on genetic structure. We assessed the genetic diversity of the endangered golden-cheeked warbler (Dendroica chrysoparia) across their breeding range in central Texas and evaluated the role of habitat loss and fragmentation in shaping the population structure of the species. We determined genotypes across nine microsatellite loci of 109 individuals from seven sites representing the major breeding concentrations of the species. No evidence of a recent population bottleneck was found. Differences in allele frequencies were highly significant among sites. The sampled sites do not appear to represent isolated lineages requiring protection as separate management units, although the amount of current gene flow is insufficient to prevent genetic differentiation. Measures of genetic differentiation were negatively associated with habitat connectivity and the percentage of forest cover between sites, and positively associated with geographic distance and the percentage of agricultural land between sites. The northernmost site was the most genetically differentiated and was isolated from other sites by agricultural lands. Fragmentation of breeding habitat may represent barriers to dispersal of birds which would pose no barrier to movement during other activities such as migration. C1 [Lindsay, Denise L.; Lance, Richard F.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Lindsay, Denise L.; Leberg, Paul L.] Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA. [Tweddale, Scott A.; Hayden, Timothy J.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Lindsay, DL (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM denise.l.lindsay@usace.army.mil NR 82 TC 50 Z9 50 U1 7 U2 38 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0962-1083 J9 MOL ECOL JI Mol. Ecol. PD MAY PY 2008 VL 17 IS 9 BP 2122 EP 2133 DI 10.1111/j.1365-294X.2008.03673.x PG 12 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA 290RK UT WOS:000255139700004 PM 18397218 ER PT J AU Kim, JH Yang, JZ Abdel-Malek, K AF Kim, Joo H. Yang, Jingzhou Abdel-Malek, Karim TI A novel formulation for determining joint constraint loads during optimal dynamic motion of redundant manipulators in DH representation SO MULTIBODY SYSTEM DYNAMICS LA English DT Article DE Denavit-Hartenberg representation; fictitious joints; optimization; motion planning; redundant manipulator; Lagrange multipliers; joint constraints; differential-algebraic equations ID RIGID-BODY DYNAMICS AB The kinematic representations of general open-loop chains in many robotic applications are based on the Denavit-Hartenberg (DH) notation. However, when the DH representation is used for kinematic modeling, the relative joint constraints cannot be described explicitly using the common formulation methods. In this paper, we propose a new formulation of solving a system of differential-algebraic equations (DAEs) where the method of Lagrange multipliers is incorporated into the optimization problem for optimal motion planning of redundant manipulators. In particular, a set of fictitious joints is modeled to solve for the joint constraint forces and moments, as well as the optimal dynamic motion and the required actuator torques of redundant manipulators described in DH representation. The proposed method is formulated within the framework of our earlier study on the generation of load-effective optimal dynamic motions of redundant manipulators that guarantee successful execution of given tasks in which the Lagrangian dynamics for general external loads are incorporated. Some example tasks of a simple planar manipulator and a high-degree-of-freedom digital human model are illustrated, and the results show accurate calculation of joint constraint loads without altering the original planned motion. The proposed optimization formulation satisfies the equivalent DAEs. C1 [Kim, Joo H.; Yang, Jingzhou; Abdel-Malek, Karim] Univ Iowa, Ctr Comp Aided Design, USA, Virtual Soldier Res Program, Iowa City, IA 52242 USA. RP Kim, JH (reprint author), Univ Iowa, Ctr Comp Aided Design, USA, Virtual Soldier Res Program, Iowa City, IA 52242 USA. EM joo-kim@uiowa.edu RI Yang, James/G-9801-2012; Kim, Joo/I-9517-2012 NR 28 TC 20 Z9 21 U1 1 U2 6 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1384-5640 J9 MULTIBODY SYST DYN JI Multibody Syst. Dyn. PD MAY PY 2008 VL 19 IS 4 BP 427 EP 451 DI 10.1007/s11044-007-9100-4 PG 25 WC Mechanics SC Mechanics GA 280XG UT WOS:000254459400006 ER PT J AU Abbott, K AF Abbott, K. C. TI A new supine anterolateral approach to percutaneous ultrasound-guided renal biopsy SO NATURE CLINICAL PRACTICE NEPHROLOGY LA English DT Editorial Material DE obese; perctltaneous renal biopsy; prone; supine anterolateral position ID KIDNEY C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. RP Abbott, K (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM kevin.abbott@amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 6 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 1745-8323 J9 NAT CLIN PRACT NEPHR JI Nat. Clin. Pract. Nephrol. PD MAY PY 2008 VL 4 IS 5 BP 244 EP 245 DI 10.1038/ncpneph0769 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA 291CK UT WOS:000255170000004 PM 18301407 ER PT J AU El-Fawal, HAN McCain, WC AF El-Fawal, Hassan A. N. McCain, Wilfred C. TI Antibodies to neural proteins in organophosphorus-induced delayed neuropathy (OPIDN) and its amelioration SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE antibodies; biomarkers; neurotoxicity; OPIDN; verapamil ID PHENYL SALIGENIN PHOSPHATE; AMYOTROPHIC-LATERAL-SCLEROSIS; FIBRILLARY ACIDIC PROTEIN; CENTRAL-NERVOUS-SYSTEM; O-CRESYL PHOSPHATE; GULF-WAR VETERANS; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; HUMORAL IMMUNITY; BRAIN AB The development of OPIDN and the efficacy of experimental intervention using the calcium-channel blocker verapamil were used as a model to test the serial time-measurements of serum autoantibodies against neuronal cytoskeletal proteins [e.g., neurofilament triplet (NF)] and glial proteins [myelin-basic protein (MBP) and glial fibrillary-acidic protein (GFAP)] as biomarkers of neurotoxicity and its amelioration. Ten White Leghorn hens (> 7 months, 1.2-1.8 kg) were administered phenyl-saligenin phosphate (PSP; 2.5 mg/kg; im), a dose reported to induce a 70% decrease in neurotoxic esterase (NTE) activity. Five of the hens were administered verapamil (7 mg/kg; im) for 4 days starting one day before PSP administration. Serum was isolated from blood collected by serial brachial venepuncture before PSP (day 0) administration and on days 3, 7 and 21 after PSP administration, each hen acting as its own control. Serum antibodies (IgG) to NF-L, NF-M, NF-H, MBP, and GFAP were assayed using an ELISA. There were no detectable levels of antibodies on days 0 and 3. IgG against all neural proteins were detected on days 7 and 21, with titer levels being significantly (p <= 0.05) higher in sera of hens receiving PSP only. Anti-NF-L titers were highest compared to those against NF-M, NF-H or MBP at 21 days. Titers of anti-NF-L and anti-MBP significantly (p <= 0.01) correlated with clinical scores at days 7 and 21. Detection of anti-NF and anti-MBP antibodies confirms the neuroaxonal degeneration accompanied by myelin loss reported in this model of OPIDN and the amelioration of neuropathy using verapamil. The detection of anti-GFAP antibodies suggests CNS involvement in OPIDN, since astrocytes are only found therein. This study demonstrates that detection of neuroantibodies can be used as biomarkers of neuropathy development and to monitor the amelioration resulting from therapeutic intervention. Together with biomarkers of exposure neuroantibodies can be used to monitor neuropathogenesis due to environmental or occupational exposures. (c) 2008 Elsevier Inc. All rights reserved. C1 [El-Fawal, Hassan A. N.] Mercy Coll, Div Hlth Profess & Nat Sci, Neurotoxicol Lab, Dobbs Ferry, NY 10522 USA. [McCain, Wilfred C.] USA, Ctr Hlth Promot & Prevent Med, Tox Evaluat Program, Aberdeen Proving Ground, MD USA. RP El-Fawal, HAN (reprint author), Mercy Coll, Div Hlth Profess & Nat Sci, Neurotoxicol Lab, 555 Broadway, Dobbs Ferry, NY 10522 USA. EM helfawal@mercy.edu NR 56 TC 6 Z9 7 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2008 VL 30 IS 3 BP 161 EP 166 DI 10.1016/j.ntt.2008.01.005 PG 6 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA 321KH UT WOS:000257303100002 PM 18353611 ER PT J AU Luz, G Nykaza, E Stewart, C Pater, L AF Luz, George Nykaza, Edward Stewart, Catherine Pater, Larry TI Use of actimeters to determine awakenings by sounds of large guns SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article ID SLEEP; NOISE AB The U.S. Army has been using the day-night average sound level (DNL) to manage the community noise impact from heavy weapons noise since the late 1970's. In this case, the DNL is C-weighted as recommended by the National Academy of Sciences-National Research Council Committee on Hearing, Bioacoustics and Biomechanics (CHABA). CHABA's recommendation was justified by the fact that C-weighting (originally developed for the loudness of intense sounds) measures lower frequency sound energy in large guns which is otherwise missed by A-weighting. When the CHABA methodology was first adopted, there was relatively little night firing, but, today, night vision technology makes firing during darkness an absolute necessity for military readiness. Recognizing that the 10-dB penalty incorporated in the DNL methodology was not intended to predict sleep disturbance and that sleep disturbance may be a function of discrete noise event levels rather than annual-average noise levels, the U.S. Army Engineer Research and Development Center initiated a project to measure sleep disturbance among people living near tank gunnery ranges. A first step in this project was to evaluate whether a commonly-used instrument for measuring sleep disturbance, the actimeter, would be sensitive to awakenings from blast noise. After preliminary screening of three designs of actimeter, the preferred design was tested in cooperation with the Air-my Center for Health Promotion and Preventive Medicine with subjects sleeping inside the Army Research Laboratory's Hostile Environment Simulator. Subjects were exposed to nighttime blasts at two linear peak sound pressure levels (11.0 dB and 120 dB). The results confirmed that the preferred design would be a reliable and rugged instrument for the actual field study of awakening from Dive fire. This article is a government work and as such, is in the public domain and not subject to copyright. C) 2008 Institute of Noise Control Engineering. C1 [Luz, George] Luz Social & Environm Associates, Baltimore, MD 21212 USA. [Nykaza, Edward; Pater, Larry] USA, Engn Res & Dev Ctr, Champaign, IL 61826 USA. [Stewart, Catherine] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Luz, G (reprint author), Luz Social & Environm Associates, 4910 Crowson Ave, Baltimore, MD 21212 USA. EM Luz_Associates@msn.com; Edward.T.Nykaza@erdc.usace.army.mil; catherine.stewart@us.army.mil; Larry.L.Pater@erdc.usace.army.mil NR 21 TC 1 Z9 1 U1 0 U2 2 PU INST NOISE CONTROL ENGINEERING PI AMES PA IOWA STATE UNIV, COLLEGE ENGINEERING, 212 MARSTON HALL, AMES, IA 50011-2152 USA SN 0736-2501 J9 NOISE CONTROL ENG J JI Noise Control Eng. J. PD MAY-JUN PY 2008 VL 56 IS 3 BP 211 EP 217 DI 10.3397/1.2938736 PG 7 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA 325FF UT WOS:000257573400005 ER PT J AU Hammond, RT AF Hammond, Richard T. TI Radiation reaction force without runaway solutions SO NUOVO CIMENTO DELLA SOCIETA ITALIANA DI FISICA B-GENERAL PHYSICS RELATIVITY ASTRONOMY AND MATHEMATICAL PHYSICS AND METHODS LA English DT Article AB An equation including radiation reaction effects without runaway solutions is derived by making the postulate that the radiation reaction force is evaluated at a different time than the external force. C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. [Hammond, Richard T.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. EM rhammond@email.unc.edu NR 20 TC 2 Z9 2 U1 0 U2 2 PU SOC ITALIANA FISICA PI BOLOGNA PA VIA SARAGOZZA, 12, I-40123 BOLOGNA, ITALY SN 1594-9982 J9 NUOVO CIMENTO B JI Nouvo Cimento Soc. Ital. Fis. B-Gen. Phys. Relativ. Astron. Math. Phys. Methods PD MAY PY 2008 VL 123 IS 5 BP 567 EP 573 DI 10.1393/ncb/i2008-10608-5 PG 7 WC Physics, Multidisciplinary SC Physics GA 399KN UT WOS:000262798900004 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Draitry Shkuratov, Yuriy Videen, Gorden TI Analytic light-scattering solution of two merging spheres using Sh-matrices SO OPTICS COMMUNICATIONS LA English DT Article ID OSCULATING SPHERES; DEFORMED DROPLETS; PARTICLES; COMPUTATIONS; INCLUSIONS AB We use the Sh-matrix formalism that contains the shape-dependent parameters of the T-matrix to derive an analytic solution for the light scattering from two merging spheres at different degrees of merging. The integral expressions for the Sh-matrix elements are simpler than those of the T-matrix elements and, for two merging spheres, these integrals can be solved analytically. Our calculations show that when the spheres merge, the primary fringes that are circular for non-merging spheres become distorted. Secondary fringes due to the interference of the waves emanating from the two spheres begin to appear when the spheres are merged approximately 50%. Published by Elsevier B.V. C1 [Videen, Gorden] USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. [Petrov, Draitry; Shkuratov, Yuriy] Kharkov VN Karazin Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. [Videen, Gorden] Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. RP Videen, G (reprint author), USA, Res Lab, AMSRD ARL CI ES, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM petrov@astron.kharkov.ua; gvideen@art.army.mil NR 11 TC 10 Z9 10 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD MAY 1 PY 2008 VL 281 IS 9 BP 2411 EP 2423 DI 10.1016/j.optcom.2007.12.079 PG 13 WC Optics SC Optics GA 295PW UT WOS:000255487400012 ER PT J AU Eckart, RE Falta, EM Stewart, RW AF Eckart, Robert E. Falta, Edward M. Stewart, Robert W. TI Complete heart block following penetrating chest trauma in operation iraqi freedom SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY LA English DT Article DE complete heart block; ventricular septal defect; trauma ID ATRIOVENTRICULAR-BLOCK; THEOPHYLLINE; MANAGEMENT AB We present a 30-year-old US army soldier who had penetrating chest trauma from a road side explosive with focal cardiac injury. The soldier had penetration of his right atrium and subsequent traumatic membranous ventricular septal defect and complete heart block. He was brought to a Combat Support Hospital where fortuitously the assigned trauma surgeon on-call was a cardiothoracic surgeon, and the assigned trauma intensivist on-call was a cardiac electrophysiologist. Of course, the only source they knew of a pacemaker was halfway around the world. We discuss the management of this injury in an austere combat environment. C1 [Eckart, Robert E.] Brooke Army Med Ctr, Cardiac Rhythmia Serv, San Antonio, TX USA. [Eckart, Robert E.; Falta, Edward M.; Stewart, Robert W.] Ibn Sina Hosp, Combat Support Hosp 28, Baghdad, Iraq. [Falta, Edward M.; Stewart, Robert W.] Walter Reed Army Med Ctr, Div Surg, Washington, DC 20307 USA. RP Eckart, RE (reprint author), Brooke Army Med Ctr, Cardiac Rhythmia Serv ATTN MCHE MDC, 3851 Roger Brooke Dr, San Antonio, TX USA. EM robert.eckart@us.army.mil NR 10 TC 1 Z9 1 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0147-8389 J9 PACE JI PACE-Pacing Clin. Electrophysiol. PD MAY PY 2008 VL 31 IS 5 BP 635 EP 638 DI 10.1111/j.1540-8159.2008.01057.x PG 4 WC Cardiac & Cardiovascular Systems; Engineering, Biomedical SC Cardiovascular System & Cardiology; Engineering GA 292SV UT WOS:000255287300021 PM 18439185 ER PT J AU Sutter, D Stagliano, D Braun, L Williams, F Arnold, J Ottolini, M Epstein, J AF Sutter, Deena Stagliano, David Braun, LoRanee Williams, Francis Arnold, John Ottolini, Martin Epstein, Judith TI Polymicrobial bloodstream infection in pediatric patients - Risk factors, microbiology, and antimicrobial management SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE bacteremia; fungemia; sepsis; catheter-related bloodstream infection ID INTENSIVE-CARE-UNIT; ENTEROCOCCAL BACTEREMIA; PARENTERAL-NUTRITION; CANCER-PATIENTS; MORTALITY; CHILDREN; ORGANISM; SEPSIS; TRANSLOCATION; EPIDEMIOLOGY AB Background: Few studies focus on polymicrobial bloodstream infections (PBSIs) in children. In previous reports, children with PBSI frequently had complex underlying medical conditions and a high incidence of specific microorganisms, but systematic evaluation with controls was not performed. We postulated that specific clinical risk factors are associated with an increased risk of PBSI, and that illness may be more severe with these infections. Additionally, we suspected that routine empiric antimicrobial therapy may frequently be inadequate to treat the variety of pathogens in PBSI. Methods: Positive blood cultures from 1998 to 2004 were reviewed. Patients whose cultures grew > 1 organism were age-matched with monomicrobial bloodstream infection controls. Records were reviewed to compare their underlying medical conditions, organisms isolated, adequacy of therapy, and clinical characteristics of illness. Results: Twenty-nine episodes of PBSI were identified in 18 subjects. PBSI patients were more likely to have chronic medical conditions, chronic gastrointestinal pathology, central venous catheters, and to be receiving parenteral nutrition than controls. Pathogens found more commonly in PBSI episodes included Enterococcus spp., coagulase-negative staphylococci, and Candida spp. Empiric antimicrobial therapy was less likely to be adequate in patients with PBSI. PBSI patients were hospitalized longer, required longer intensive care and had prolonged bloodstream infection. Subjects with PBSI had prolonged duration of fever and had higher degrees of sepsis than controls. Conclusions: Chronic medical conditions, particularly gastrointestinal disease, are risk factors for PBSIs. Because clinical illness may be more severe, alteration of the empiric antimicrobial regimen should be considered in some of these patients. C1 [Sutter, Deena; Braun, LoRanee; Ottolini, Martin] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Sutter, Deena; Stagliano, David; Braun, LoRanee] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Williams, Francis; Epstein, Judith] Naval Med Res Ctr, Silver Spring, MD USA. [Arnold, John] USN, Ctr Med, San Diego, CA 92152 USA. RP Sutter, D (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM dsutter@usuhs.mil NR 32 TC 14 Z9 16 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD MAY PY 2008 VL 27 IS 5 BP 400 EP 405 DI 10.1097/INF.0b013e31816591be PG 6 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 296HN UT WOS:000255534200005 PM 18398386 ER PT J AU Sawyer, T AF Sawyer, Taylor TI Withdrawing support for withdrawing support from premature infants with severe intracranial hemorrhage SO PEDIATRICS LA English DT Letter ID INTENSIVE-CARE C1 Univ Hawaii Program, Tripler Army Med Ctr, Kapiolani Med Ctr Women & Children, Honolulu, HI 96859 USA. RP Sawyer, T (reprint author), Univ Hawaii Program, Tripler Army Med Ctr, Kapiolani Med Ctr Women & Children, Honolulu, HI 96859 USA. NR 4 TC 4 Z9 4 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 2008 VL 121 IS 5 BP 1071 EP 1072 DI 10.1542/peds.2008-0273 PG 5 WC Pediatrics SC Pediatrics GA 295VL UT WOS:000255501900029 PM 18450917 ER PT J AU Borysenko, KM Semenov, YG Kim, KW Zavada, JM AF Borysenko, K. M. Semenov, Y. G. Kim, K. W. Zavada, J. M. TI Electron spin relaxation via flexural phonon modes in semiconducting carbon nanotubes SO PHYSICAL REVIEW B LA English DT Article ID QUANTUM DOTS; TRANSPORT AB This work considers the g-tensor anisotropy induced by the flexural thermal vibrations in one-dimensional structures and its role on electron spin relaxation. In particular, the mechanism of spin-lattice relaxation via flexural modes is theoretically studied for localized and delocalized electronic states in semiconducting carbon nanotubes in the presence of a magnetic field. The calculation of a one-phonon spin-flip process predicts distinctive dependencies of the relaxation rate on temperature, magnetic field, and nanotube diameter. A comparison to the spin relaxation caused by the hyperfine interaction clearly suggests the relative efficiency of the proposed mechanism at sufficiently high temperatures. Specifically, the longitudinal spin relaxation time in the semiconducting carbon nanotubes is estimated to be as short as 30 mu s at room temperature. C1 [Borysenko, K. M.; Semenov, Y. G.; Kim, K. W.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Zavada, J. M.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Borysenko, KM (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. NR 28 TC 8 Z9 8 U1 2 U2 5 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAY PY 2008 VL 77 IS 20 AR 205402 DI 10.1103/PhysRevB.77.205402 PG 6 WC Physics, Condensed Matter SC Physics GA 316TE UT WOS:000256971800088 ER PT J AU Helling, ER Okoro, S Kim, G Wang, PTH AF Helling, Eric R. Okoro, Stanley Kim, George, II Wang, Peter T. H. TI Endoscope-assisted temporoparietal fascia harvest for auricular reconstruction SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article; Proceedings Paper CT 63rd Annual Meeting of the American-Cleft-Palate-Craniofacial-Association CY APR 03-08, 2006 CL Vancouver, CANADA SP Amer Cleft Palate Craniofacial Assoc ID POROUS POLYETHYLENE IMPLANT; FREE FLAPS AB Background: Reconstruction of microtia may require a temporoparietal fascia flap. The authors modified existing endoscopic temporoparietal fascia harvest techniques and applied them to auricular reconstruction to reduce incision size, scarring, and visible alopecia. Flap design was altered to include posterior occipital circulation to improve perfusion and decrease venous congestion. Cases of open and endoscope-assisted auricular reconstruction techniques have not been compared in the literature. Methods: Seventeen patients underwent Medpor auricular reconstruction with temporoparietal fascia flaps (eight open and nine endoscope-assisted). Physical outcome (scar size, location, appearance, and complication rate), flap size, surgical times, and blood loss were compared. Equipment and dissection techniques are reviewed. Results: No flap complications occurred with either group. Endoscope-assisted incision length was 18 to 25 mm, compared with 150 to 200 mm using the open technique. No significant alopecia was noted in the endoscopic group, whereas most open patients had visible alopecia. Open surgical time averaged 325.9 minutes, and endoscopic surgical time averaged 276.5 minutes. Estimated blood loss averaged 56.3 cc for open and 45.6 cc for endoscopic procedures. Open temporoparietal fascia flap size averaged 8.87 x 9.75 cm, whereas endoscopic temporoparietal fascia flap size averaged 7.9 x 10.2 cm. Standard endoscopic brow-lift instruments were used. The optimal superior access port placement was the upper one-third/lower two-thirds junction of the flap. Conclusions: The endoscope-assisted temporoparietal fascia harvest technique for auricular reconstruction can minimize scarring, alopecia, and surgical time, with comparable blood loss. Flap size is comparable to that of the traditional open approach. The authors recommend a broadly based pedicle instead of one based solely off the superficial temporal artery. C1 [Helling, Eric R.] Tripler Army Med Ctr, Plast Surg Serv, Honolulu, HI 96859 USA. [Helling, Eric R.; Okoro, Stanley; Kim, George, II; Wang, Peter T. H.] Univ Texas Hlth Sci Ctr San Antonio, Plast Surg Serv, San Antonio, TX 78229 USA. RP Helling, ER (reprint author), Tripler Army Med Ctr, Plast Surg Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM eric.helling@us.army.mil NR 12 TC 19 Z9 21 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD MAY PY 2008 VL 121 IS 5 BP 1598 EP 1605 DI 10.1097/PRS.0b013e31816a9fb9 PG 8 WC Surgery SC Surgery GA 294VU UT WOS:000255435200010 PM 18453982 ER PT J AU Li, J Zhang, C Liang, R Wang, B Walsh, S AF Li, Jing Zhang, Chuck Liang, Richard Wang, Ben Walsh, Shawn TI Modeling and analysis of thickness gradient and variations in vacuum-assisted resin transfer molding process SO POLYMER COMPOSITES LA English DT Article ID TEXTILE REINFORCEMENTS; COMPACTION; SIMULATION; VOLUME; FLOW AB As vacuum-assisted resin transfer molding (VARTM) is being increasingly used in aerospace applications, the thickness gradient and variation issues are gaining more attention. Typically, thickness gradient and variations result from the infusion pressure gradient during the process and material variations. Pressure gradient is the driving force for resin flow and the main source of thickness variation. After infusion, an amount of pressure gradient is frozen into the preform, which primarily contributes to the thickness variation. This study investigates the mechanism of the thickness variation dynamic change during the infusion and relaxing/curing processes. A numerical model was developed to track the thickness change of the bagging film free surface. A time-dependent permeability model as a function of compaction pressure was incorporated into an existing resin transfer molding (RTM) code for obtaining the initial conditions for relaxing/curing process. Control volume (CV) and volume of fluid (VOF) methods were combined to solve the free surface problem. Experiments were conducted to verify the simulation results. The proposed model was illustrated with a relatively complex part. C1 [Li, Jing; Zhang, Chuck; Liang, Richard; Wang, Ben] Florida State Univ, Florida A&M Univ, Coll Engn, HPMI,Dept Ind & Mfg Engn, Tallahassee, FL 32310 USA. [Walsh, Shawn] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, C (reprint author), Florida State Univ, Florida A&M Univ, Coll Engn, HPMI,Dept Ind & Mfg Engn, Tallahassee, FL 32310 USA. EM chzhang@eng.fsu.edu NR 17 TC 23 Z9 25 U1 4 U2 15 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0272-8397 J9 POLYM COMPOSITE JI Polym. Compos. PD MAY PY 2008 VL 29 IS 5 BP 473 EP 482 DI 10.1002/pc.20439 PG 10 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA 293DG UT WOS:000255314500002 ER PT J AU Arbuckle, MR Gameroff, MJ Marcus, SC West, JC Wilk, J Olfson, M AF Arbuckle, Melissa R. Gameroff, Marc J. Marcus, Steven C. West, Joyce C. Wilk, Joshua Olfson, Mark TI Psychiatric opinion and antipsychotic selection in the management of schizophrenia SO PSYCHIATRIC SERVICES LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; PHARMACEUTICAL-INDUSTRY; 2ND-GENERATION ANTIPSYCHOTICS; DRUGS; PHYSICIANS; GUIDELINE; COST AB Objectives: This study examined psychiatrists' opinions regarding the use of second-generation antipsychotics for treatment-resistant schizophrenia. It then sought to identify factors associated with these opinions. Methods: A national survey was conducted (September 2003-January 2004) of psychiatrists engaged in the management of patients with schizophrenia. Results: Among survey respondents (N=431), most psychiatrists (88%) believed that one or more of the five currently available second-generation antipsychotics could improve treatment-resistant positive symptoms after a failed trial of optimal oral haloperidol treatment. Psychiatrists who reported familiarity with schizophrenia practice guidelines were more likely to have high levels of optimism that these medications improve positive symptoms (odds ratio [OR]=3.6, 95% confidence interval [CI]=1.4-9.3, p=.009). Psychiatrists who met with a pharmaceutical representative at least once a week were also more likely to have high levels of optimism toward second-generation antipsychotics (OR=2.3, CI=1.4-3.9, p=.001). Conclusions: Reported familiarity with treatment guidelines and frequent contact with pharmaceutical representatives appear to be associated with optimism toward second-generation antipsychotics. C1 [Olfson, Mark] Columbia Univ, New York State Psychiat Inst, Dept Psychiat, New York, NY 10032 USA. [Arbuckle, Melissa R.; Gameroff, Marc J.; Olfson, Mark] New York State Psychiat Inst & Hosp, New York, NY 10032 USA. [Marcus, Steven C.] Univ Penn, Dept Social Policy & Practice, Philadelphia, PA USA. [West, Joyce C.] Amer Psychiat Inst Res & Educ, Arlington, VA USA. [Wilk, Joshua] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. RP Olfson, M (reprint author), Columbia Univ, New York State Psychiat Inst, Dept Psychiat, 1051 Riverside Dr, New York, NY 10032 USA. EM mo49@columbia.edu FU NIMH NIH HHS [MH 61530] NR 17 TC 9 Z9 9 U1 0 U2 0 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD MAY PY 2008 VL 59 IS 5 BP 561 EP 565 DI 10.1176/appi.ps.59.5.561 PG 5 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 296AQ UT WOS:000255516300019 PM 18451017 ER PT J AU Cohen, SP Christo, PJ Wang, S Chen, L Stojanovic, MP Shields, CH Brummett, C Mao, J AF Cohen, Steven P. Christo, Paul J. Wang, Shuxing Chen, Lucy Stojanovic, Milan P. Shields, Cynthia H. Brummett, Chad Mao, Jianren TI The effect of opioid dose and treatment duration on the perception of a painful standardized clinical stimulus SO REGIONAL ANESTHESIA AND PAIN MEDICINE LA English DT Article DE hyperalgesia; nerve block; opioid; pain perception; tolerance ID FACET RADIOFREQUENCY DENERVATION; METHADONE-MAINTENANCE PATIENTS; TOLERANCE; MORPHINE; FAILURE; SUCCESS AB Background and objectives: The concept of opioid-induced hyperalgesia has recently gained prominence as a contributing factor for opioid tolerance and long-term treatment failure. But whereas the preclinical data for this phenomenon are strong, the mixed clinical data derive primarily from experimental pain models conducted in volunteers and heroin addicts, and nonstandardized clinical stimuli, e.g., surgery. The primary objective of this study is to delineate the effect of opioid dose and treatment duration on pain intensity and unpleasantness ratings following a standardized clinical pain stimulus. Methods: Three hundred and fifty-five patients, on a steady regimen of analgesic medications and scheduled for an interventional procedure, received a standardized subcutaneous injection of lidocaine prior to a full dose of local anesthetic. Before and immediately following the injection, subjects were asked to rate pain and unpleasantness intensity on a 0 to 10 numerical rating scale. Subjects were stratified into 6 groups based on opioid dosage. A control group of 27 volunteers who had no pain and were taking no analgesics were also injected. Results: Both opioid dose and duration of treatment directly correlated with pain intensity and unpleasantness scores. Baseline pain intensity was also positively associated with both outcome variables. Gender was found to be associated with pain intensity and unpleasantness, with females scoring higher in both categories than males. Compared with patients not receiving opioid treatment, patients receiving opioid therapy were more likely to rate the standardized pain stimulus as being more unpleasant than painful. Conclusions: The results of this study bolster preclinical and experimental pain models demonstrating enhanced pain perception in subjects receiving opioid therapy. This simple clinical model may provide a useful tool in examining opioid-induced hyperalgesia. C1 [Cohen, Steven P.; Christo, Paul J.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.; Shields, Cynthia H.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Wang, Shuxing; Chen, Lucy; Stojanovic, Milan P.; Mao, Jianren] Harvard Univ, Sch Med, Dept Anesthesia & Crit Care, Boston, MA USA. [Stojanovic, Milan P.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Boston, MA USA. [Brummett, Chad] Univ Michigan, Sch Med, Dept Anesthesiol, Ann Arbor, MI USA. RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu OI Brummett, Chad/0000-0003-0974-7242 NR 19 TC 47 Z9 48 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1098-7339 J9 REGION ANESTH PAIN M JI Region. Anesth. Pain Med. PD MAY-JUN PY 2008 VL 33 IS 3 BP 199 EP 206 DI 10.1016/j.rapm.2007.10.009 PG 8 WC Anesthesiology SC Anesthesiology GA 297LE UT WOS:000255617400002 PM 18433669 ER PT J AU Brown, KS DeLeon, PH Loftis, CW Scherer, MJ AF Brown, Kathleen S. DeLeon, Patrick H. Loftis, Christopher W. Scherer, Marcia J. TI Rehabilitation psychology: Realizing the true potential SO REHABILITATION PSYCHOLOGY LA English DT Article DE rehabilitation; psychology; disability; health care; leadership ID OLD-AGE DISABILITY; HEALTH-CARE; PAIN MANAGEMENT; TRENDS; AFGHANISTAN; TECHNOLOGY; MORTALITY; SCIENCE; BURDEN; IRAQ AB As the Division of Rehabilitation Psychology (Division 22) celebrates its 50th anniversary this year, this article reflects on the current status and important trends in health care and technology that are likely to have the largest impact on the science and practice of rehabilitation psychologists in the next decade. These trends include the prevalence of chronic conditions, health disparities, Operation Iraqi Freedom and Operation Enduring Freedom injuries, and caregiver burden. The implications of these trends are also discussed in the context of rehabilitation psychologists' involvement in public policy. C1 [Brown, Kathleen S.] Tripler Army Med Ctr, Pain Rehabil Program, MCHK PH, Honolulu, HI 96859 USA. [Loftis, Christopher W.] Natl Hlth Policy Forum, Washington, DC USA. [Scherer, Marcia J.] Inst Matching Person & Technol Inc, Webster, NY USA. RP Brown, KS (reprint author), Tripler Army Med Ctr, Pain Rehabil Program, MCHK PH, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM ksbrown@hawaii.rr.com OI Scherer, Marcia/0000-0001-8374-6526 NR 75 TC 4 Z9 5 U1 3 U2 3 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 0090-5550 J9 REHABIL PSYCHOL JI Rehabil. Psychol. PD MAY PY 2008 VL 53 IS 2 BP 111 EP 121 DI 10.1037/0090-5550.53.2.111 PG 11 WC Psychology, Clinical; Rehabilitation SC Psychology; Rehabilitation GA 313AF UT WOS:000256712800001 ER PT J AU Smith, R AF Smith, Roger TI The evolution of innovation SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Editorial Material C1 US Army Simulat, Orlando, FL USA. RP Smith, R (reprint author), US Army Simulat, Orlando, FL USA. EM rdsmith@modelbenders.com NR 12 TC 0 Z9 0 U1 0 U2 1 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD MAY-JUN PY 2008 VL 51 IS 3 BP 59 EP 62 PG 4 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA 294BO UT WOS:000255379300011 ER PT J AU King, CS Moores, LK AF King, Christopher S. Moores, Lisa K. TI Clinical asthma syndromes and important asthma mimics SO RESPIRATORY CARE LA English DT Article; Proceedings Paper CT 41st Respiratory Care Journal Conference on Meeting the Challenges of Asthma CY SEP 28-30, 2007 CL Scottsdale, AZ DE asthma; phenotypes; asthma, etiology; asthma, genetics; asthma, mimics; vocal cord dysfunction ID OBSTRUCTIVE PULMONARY-DISEASE; VOCAL CORD DYSFUNCTION; ASPIRIN-INDUCED ASTHMA; AIR-FLOW OBSTRUCTION; NEAR-FATAL ASTHMA; MENSTRUAL-CYCLE; RISK-FACTORS; EMERGENCY-DEPARTMENT; OCCUPATIONAL ASTHMA; CHRONIC-BRONCHITIS AB Asthma is a heterogeneous disorder with multiple clinical phenotypes. Phenotypes can be grouped into clinical or physiological, trigger-defined, and inflammatory phenotypes. Treatment based on inflammatory phenotyping improves clinical measures of asthma morbidity. Further study of individual asthma phenotypes will improve understanding of their immunologic and pathologic characteristics and improve diagnosis and therapy. Because asthma is a common disorder with nonspecific presenting features, other disorders are often misdiagnosed as asthma. A high index of suspicion for alternative diagnoses must be maintained when evaluating a patient who presents with clinical features suggestive of asthma, particularly if the patient presents with atypical symptoms or fails to respond to therapy. C1 [Moores, Lisa K.] Uniformed Serv Univ Hlth Sci, Dept Med, Off Student Affairs, Bethesda, MD 20814 USA. [King, Christopher S.] Walter Reed Army Med Ctr, Dept Med, Pulm Crit Care & Sleep Med Serv, Washington, DC 20307 USA. RP Moores, LK (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Off Student Affairs, 4310 Jones Bridge Rd, Bethesda, MD 20814 USA. EM lmoores@usuhs.mil NR 68 TC 15 Z9 15 U1 0 U2 0 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD MAY PY 2008 VL 53 IS 5 BP 568 EP 580 PG 13 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 300EC UT WOS:000255806100004 PM 18426611 ER PT J AU Clark, MD Carroll, MH AF Clark, M. Diane Carroll, Marjorie H. TI Acquaintance rape scripts of women and men: Similarities and differences SO SEX ROLES LA English DT Article DE acquaintance rape; scripts; traditional sexual script; sex differences ID SEXUAL ASSAULT PERPETRATION; LONGITUDINAL EXAMINATION; SEDUCTION SCRIPTS; COLLEGE-STUDENTS; MYTH ACCEPTANCE; VICTIMIZATION; EXPERIENCES; AGGRESSION; UNIVERSITY; ACKNOWLEDGMENT AB Building on Carroll and Clark (Sex Roles 55:469-480, 2006), the current study examined whether women's scripts overlap or diverge from acquaintance rape scripts reported by men. Using a preset rape scenario, scripts were elicited from a sample of 292 women and 125 men from the United States. A mixed-methods approach was utilized, including a content analysis of script themes as well as modeling analyses to examine gender differences in underlying latent structures. The findings confirm that, for both women and men, there is not a single rape script. However, when looking at latent structures, there is clear evidence of the diverging conceptualization of rape for women and men. Findings highlight how the Traditional Sexual Script continues to influence one's understanding of cultural scenarios. C1 [Carroll, Marjorie H.] US Mil Acad, Dept Behav Sci & Leadership, Official Mail & Distribut Ctr, West Point, NY 10996 USA. [Clark, M. Diane] Gallaudet Univ, Dept Educ Fdn & Res, Washington, DC 20002 USA. RP Carroll, MH (reprint author), US Mil Acad, Dept Behav Sci & Leadership, Official Mail & Distribut Ctr, 646 Swift Rd, West Point, NY 10996 USA. EM diane.clark@gallaudet.edu; marjorie.carroll@usma.edu NR 43 TC 12 Z9 12 U1 2 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0360-0025 J9 SEX ROLES JI Sex Roles PD MAY PY 2008 VL 58 IS 9-10 BP 616 EP 625 DI 10.1007/s11199-007-9373-3 PG 10 WC Psychology, Developmental; Psychology, Social; Women's Studies SC Psychology; Women's Studies GA 286MN UT WOS:000254850100002 ER PT J AU Clapp, CE Shenker, M Hayes, MHB Liu, R Cline, VW Palazzo, AJ Gen, Y AF Clapp, C. Edward Shenker, Moshe Hayes, Michael H. B. Liu, Raymond Cline, Van W. Palazzo, Antonio J. Gen, Yona TI Microsystems for rapid evaluation of plant growth response to organic amendments SO SOIL SCIENCE LA English DT Article DE bio-assay; humic substances; organic matter; plant response ID HUMIC SUBSTANCES; COMPOST MATURITY; STIMULATION; MATTER; SOILS AB Organic matter (OM)-based amendments offered to farmers vary greatly in their source, properties, and effectiveness. Some of these are produced from natural organic resources, whereas others originate from recycled organic waste, in part as an environment-friendly low-cost alternative to waste disposal. Stimulatory effects of OM on plant growth have been noticed in many systems, but a few reports have indicated negative effects. Many factors and interactions dictate plant response to these materials, and not all are well understood. Procedures that can be used to evaluate OM composition and characteristics that might affect plant growth are complicated and expensive. Deleterious effects of OM additions are frequently associated with a nonmature status of the decomposing material, but maturity is difficult to define. Evaluation of humic substances (HS)-based products is even more complex and needs improvement of the available methodologies. This article presents two simple versatile bioassay methods carried out in microplates or pouches for screening and evaluating soluble organic products for agronomic and horticultural use. To illustrate the two methods, we present microplate experiments with creeping bentgrass (Agrostis palustris Huds.) that provide an evaluation of plant response to N rates spanning from deficient to excessive levels (0.9-57.6 mg N L-1) and to 11 different soluble HS products. The pouch method is presented by soybean (Glycine max L.) and corn (Zea mays L.) experiments that evaluate plant response to two HS and determine whether it is related to Fe or Zn mediation by the tested substances. The two methods are shown to be sensitive for nutritional factors and could effectively rank various OM materials from being deleterious to stimulatory to plant growth. C1 [Clapp, C. Edward] USDA ARS, St Paul, MN 55108 USA. [Clapp, C. Edward] Univ Minnesota, Dept Soil Water & Climate, St Paul, MN 55108 USA. [Shenker, Moshe; Gen, Yona] Hebrew Univ Jerusalem, Dept Soil & Water Sci, IL-76100 Rehovot, Israel. [Hayes, Michael H. B.] Univ Limerick, Dept Chem & Environm Sci, Limerick, Ireland. [Liu, Raymond] CK Life Sci Ltd, Hong Kong, Hong Kong, Peoples R China. [Cline, Van W.] Toro Co, Bloomington, MN 55420 USA. [Palazzo, Antonio J.] USACOE, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Clapp, CE (reprint author), USDA ARS, St Paul, MN 55108 USA. EM eclapp@umn.edu RI Hayes, Michael/C-3463-2011 NR 23 TC 1 Z9 1 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-075X J9 SOIL SCI JI Soil Sci. PD MAY PY 2008 VL 173 IS 5 BP 342 EP 349 DI 10.1097/SS.0b013e31816d1ef7 PG 8 WC Soil Science SC Agriculture GA 301GT UT WOS:000255885100005 ER PT J AU Levsky, ME Miller, MA Masneri, DA Borys, D AF Levsky, Marc E. Miller, Michael A. Masneri, David A. Borys, Doug TI Colchicine exposures: The Texas experience SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE colchicine; outcomes; toxicity ID FAB FRAGMENTS; OVERDOSE; FEATURES; PLANT; GOUT AB Objectives: Colchicine is a relatively uncommon toxin, but is known to precipitate severe multiorgan failure in overdose. Little is known about exposure patterns and outcomes in cases of colchicine ingestion. Our goal was to add to toxicologic knowledge through a database review and descriptive study of colchicine exposures. Methods: Texas Poison Center Network Data was reviewed for the years 2000 to 2005, and all reports of colchicine exposures were reviewed. Results: A total of 79 cases were found in the time period studied. The most common exposure reasons were unintentional-therapeutic error (33%), unintentional-general (28%), and intentional-suspected suicide (18%). Medical outcomes included no effect (24%), minor effect (20%), moderate effect (15%), and major effect (3%). The most common clinical findings included vomiting (20%), diarrhea (17%), and abdominal pain (7%). The most commonly employed therapies were dilution (28%), single-dose activated charcoal (26%), cathartics (16%), and gastrointestinal lavage (15%). Conclusion: The majority of cases of exposure produced no significant effects, and fatality was uncommon in this sample. Colchicine is a relatively uncommon toxin among therapeutic drugs, and though capable of it, is rarely responsible for significant morbidity or mortality. Meticulous exposure record keeping at poison centers is a key to the study of patterns of toxicity with uncommon toxins such as colchicine. C1 [Miller, Michael A.] Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. Darnall Army Community Hosp, Ft Hood, TX USA. Tripler Army Med Ctr, Ctr Excellence Disaster Med & Humanitarian Assist, Honolulu, HI 96859 USA. Cent Texas Poison Ctr, Temple, TX USA. RP Miller, MA (reprint author), Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. EM michael.adam.miller@us.army.mil NR 21 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAY PY 2008 VL 101 IS 5 BP 480 EP 483 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 297LL UT WOS:000255618100014 PM 18414172 ER PT J AU Cohen, SP Stojanovic, MP Crooks, M Kim, P Schmidt, RK Shields, CH Croll, S Hurley, RW AF Cohen, Steven P. Stojanovic, Milan P. Crooks, Matthew Kim, Peter Schmidt, Rolf K. Shields, Cynthia H. Croll, Scott Hurley, Robert W. TI Lumbar zygapophysial (facet) joint radiofrequency denervation success as a function of pain relief during diagnostic medial branch blocks: a multicenter analysis SO SPINE JOURNAL LA English DT Article DE denervation; facet joint; low back pain; medical branch block; predictive value; radiofrequency; zygapophysial joint ID LOW-BACK-PAIN; CHRONIC NECK PAIN; DOUBLE-BLIND; CONTROLLED TRIAL; SINGLE-NEEDLE; NEUROTOMY; EFFICACY; SPECIFICITY; PREVALENCE; INJECTION AB BACKGROUND CONTEXT: The publication of several recent studies showing minimal benefit for radiofrequency (RF) lumbar zygapophysial (1-z) joint denervation have led many investigators to reevaluate selection criteria. One controversial explanation for these findings is that the most commonly used cutoff value for selecting patients for 1-z (facet) joint RF denervation, greater than 50% pain relief after diagnostic blocks, is too low and hence responsible for the high failure rate. PURPOSE: To compare 1-z joint RF denervation success rates between the conventional greater than or equal to 50% pain relief threshold and the more stringently proposed greater than or equal to 80% cutoff for diagnostic medial branch blocks (MBB). STUDY DESIGN/SETTING: Multicenter, retrospective clinical data analysis. PATIENT SAMPLE: Two hundred and sixty-two patients with chronic low back pain who underwent 1-z RF denervation at three pain clinics. OUTCOME MEASURES: Outcome measures were greater than 50% pain relief based on visual analog scale or numerical pain rating score after RF denervation persisting at least 6 months post-procedure, and global perceived effect (GPE), which considered pain relief, satisfaction and functional improvement. METHODS: Data were garnered at three centers on 262 patients who underwent 1-z RF denervation after obtaining greater than or equal to 50% pain relief after diagnostic MBB. Subjects were separated into those who received partial (greater than or equal to 50% but less than 80%) and near-complete (greater than or equal to 80%) pain relief from the MBB. Outcomes between groups were compared with multivariate analysis after controlling for 14 demographic and clinical variables. RESULTS: One hundred and forty-five patients obtained greater than or equal to 50% but less than 80% pain relief after diagnostic MBB, and 117 patients obtained greater than or equal to 80% relief. In the greater than or equal to 50% group, success rates were 52% and 67% based on pain relief and GPE, respectively. Among patients who experienced greater than 80% relief from diagnostic blocks, 56% obtained greater than or equal to 50% relief from RF denervation and 66% had a positive GPE. CONCLUSIONS: Using more stringent pain relief criteria when selecting patients for 1-z joint RF denervation is unlikely to improve success rates, and may lead to misdiagnosis and withholding a potentially valuable treatment from good candidates. (C) 2008 Elsevier Inc. All rights reserved. C1 [Cohen, Steven P.; Crooks, Matthew; Hurley, Robert W.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Pain Management Div, Baltimore, MD 21029 USA. [Cohen, Steven P.; Schmidt, Rolf K.; Shields, Cynthia H.; Croll, Scott] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Stojanovic, Milan P.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Anesthesiol & Crit Care,Pain Management Div, Boston, MA 02144 USA. [Kim, Peter] Univ So Calif, Sch Med, Dept Anesthesiol, Los Angeles, CA 90033 USA. RP Cohen, SP (reprint author), Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Pain Management Div, 550 North Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu NR 41 TC 40 Z9 40 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD MAY-JUN PY 2008 VL 8 IS 3 BP 498 EP 504 DI 10.1016/j.spinee.2007.04.022 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 305MA UT WOS:000256181300011 PM 17662665 ER PT J AU Chang, MH Pang, T Pemy, M AF Chang, Mou-Hsiung Pang, Tao Pemy, Moustapha TI Finite difference approximations for stochastic control systems with delay SO STOCHASTIC ANALYSIS AND APPLICATIONS LA English DT Article DE finite difference approximation; stochastic control; stochastic functional differential equations; viscosity solutions AB This article considers the computation issues of the infinite dimensional HJB equation arising from the finite horizon optimal control problem of a general system of stochastic functional differential equations with a bounded memory treated in [2]. The finite difference scheme, using the result in [1], is obtained to approximate the viscosity solution of the infinite dimensional HJB equation. The convergence of the scheme is proved using the Banach fixed point theorem. The Computational algorithm also is provided based on the scheme obtained. C1 [Pang, Tao] N Carolina State Univ, Dept Math, Raleigh, NC 27695 USA. [Chang, Mou-Hsiung] USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. [Pang, Tao] N Carolina State Univ, Ctr Res Sci Computat, Raleigh, NC 27695 USA. [Pemy, Moustapha] Towson Univ, Dept Math, Towson, MD USA. RP Pang, T (reprint author), N Carolina State Univ, Dept Math, Box 8205, Raleigh, NC 27695 USA. EM tpang@ncsu.edu NR 15 TC 8 Z9 8 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0736-2994 J9 STOCH ANAL APPL JI Stoch. Anal. Appl. PD MAY-JUN PY 2008 VL 26 IS 3 BP 451 EP 470 DI 10.1080/07362990802006980 PG 20 WC Mathematics, Applied; Statistics & Probability SC Mathematics GA 303QS UT WOS:000256056200002 ER PT J AU Pak, HS Brown-Connolly, NE Bloch, C Clarke, M Clyburn, C Doarn, CR Llewellyn, C Merrell, RC Montgomery, K Rasche, J Sullivan, B AF Pak, Hon S. Brown-Connolly, Nancy E. Bloch, Carolyn Clarke, Malcolm Clyburn, Conrad Doarn, Charles R. Llewellyn, Craig Merrell, Ronald C. Montgomery, Kevin Rasche, Jeanette Sullivan, Bradley TI Global Forum on Telemedicine: Connecting the World Through Partnerships SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Article AB The American Telemedicine Association (ATA) held the Global Forum on Telemedicine: Connecting the World Through Partnerships in September 2007 with sponsorship by the Telemedicine and Advanced Technology Research Center (TATRC), U. S. Army Medical Research and Materiel Command (USAMRMC). The goal was to bring together key stakeholders in global healthcare outreach to explore a flexible framework and sustainable business model that can leverage telemedicine and information technology (IT) to expand healthcare services internationally. Dr. Hon S. Pak, President of the ATA, opened the forum with a call for collaboration and partnership, and encouraged continued international dialogue to create a framework that leverages the telemedicine community to improve global disparity in healthcare. Keynote addresses included speakers from the World Health Organization (UN) and United Nations (UN) Global Alliance for Information and Communities Technologies and Development (GAID). Presentations from 15 government and nongovernment aid organizations (NGOs) and 12 international programs covered 5 key areas: (1) NGO perspective; (2) governmental/military programs; (3) financial sustainability; (4) disaster response; and (5) emerging opportunities. The forum resulted in an International Roadmap for Action that was developed by the authors based on the presentations and interactions from the 335 attendees and establishing a set of priorities and actions to improve healthcare using telemedicine and IT. Recommendations include: (1) continued dialogue in creating a telemedicine framework; (2) identification and leverage of resources; (3) provision of education to funding organization and expand training programs to build competency in the healthcare workforce; (4) alignment of international policy to support integration of telemedicine into country plans and support cross-country partnerships; (5) development of communications infrastructure; and (6) integration of telemedicine into disaster relief programs. C1 [Brown-Connolly, Nancy E.; Montgomery, Kevin] USAMRMC, TATRC, Ft Detrick, MD 21702 USA. [Pak, Hon S.] Amer Telemed Assoc, Washington, DC USA. [Bloch, Carolyn] Bloch Consulting Grp, Potomac, MD USA. [Clarke, Malcolm] Brunel Univ, Dept Informat Syst & Comp, Uxbridge UB8 3PH, Middx, England. [Clyburn, Conrad] Georgetown Univ, Washington, DC USA. [Doarn, Charles R.] Univ Cincinnati, Ctr Surg Innovat, Cincinnati, OH USA. [Llewellyn, Craig] Ctr Disaster & Humanitarian & Assistance Med, Bethesda, MD USA. [Merrell, Ronald C.] Virginia Commonwealth Univ, Richmond, VA USA. [Rasche, Jeanette] USAMRMC, TATRC, Ft Gordon, GA USA. RP Brown-Connolly, NE (reprint author), USAMRMC, TATRC, Ft Detrick, MD 21702 USA. EM connolly@tatrc.org OI Clarke, Malcolm/0000-0002-4345-3347 NR 12 TC 5 Z9 5 U1 1 U2 8 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD MAY PY 2008 VL 14 IS 4 BP 389 EP 395 DI 10.1089/tmj.2008.0030 PG 7 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 310HF UT WOS:000256518800017 PM 18570571 ER PT J AU Izadjoo, MJ Mense, MG Bhattacharjee, AK Hadfield, TL Crawford, RM Hoover, DL AF Izadjoo, M. J. Mense, M. G. Bhattacharjee, A. K. Hadfield, T. L. Crawford, R. M. Hoover, D. L. TI A study on the use of male animal models for developing a live vaccine for brucellosis SO TRANSBOUNDARY AND EMERGING DISEASES LA English DT Article DE Brucella; vaccine; animal models ID MELITENSIS INFECTION; UNITED-STATES; MICE; COMPLICATIONS; PROTECTION; DELETION; 16M AB To study the safety of Brucella melitensis WR201, a live vaccine candidate, we compared the course of infection of this strain with that of virulent 16M in male BALB/c mice. At various times after oral immunization with strains WR201 or 16M, lungs, liver, spleen, testis, epididymis, inguinal and cervical lymph nodes were removed. Tissues were divided for microbiologic culture and histopathological examination. WR201 infection in male BALB/c mice had lower intensity and shorter duration than infection caused by virulent 16M. Pathological examination of testis and epididymis revealed no inflammation following strain WR201 immunization. In contrast, animals given virulent 16M strain had substantial inflammation in infected tissues. These data confirm the marked attenuation of WR201 relative to 16M. In addition, these studies suggest that male mice may be useful to assess the safety of live, attenuated Brucella vaccine candidates. C1 [Izadjoo, M. J.; Mense, M. G.; Hadfield, T. L.; Crawford, R. M.] Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Washington, DC 20306 USA. [Bhattacharjee, A. K.; Hoover, D. L.] Walter Reed Army Inst Res, Dept Bacterial Dis, Silver Spring, MD 20910 USA. RP Izadjoo, MJ (reprint author), Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Washington, DC 20306 USA. EM izadjoo@afip.osd.mil NR 19 TC 9 Z9 11 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1865-1674 J9 TRANSBOUND EMERG DIS JI Transbound. Emerg. Dis. PD MAY PY 2008 VL 55 IS 3-4 BP 145 EP 151 DI 10.1111/j.1865-1682.2008.01019.x PG 7 WC Infectious Diseases; Veterinary Sciences SC Infectious Diseases; Veterinary Sciences GA 308HV UT WOS:000256380400001 PM 18405337 ER PT J AU Saathoff, E Schneider, P Kleinfeldt, V Geis, S Haule, D Maboko, L Samky, E de Souza, M Robb, M Hoelscher, M AF Saathoff, Elmar Schneider, Philine Kleinfeldt, Vera Geis, Steffen Haule, Dennis Maboko, Leonard Samky, Eleuter de Souza, Mark Robb, Merlin Hoelscher, Michael TI Laboratory reference values for healthy adults from southern Tanzania SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE reference values; chemistry; clinical; haematology; immunophenotyping; adult; Africa ID IMMUNOHEMATOLOGICAL REFERENCE RANGES; REFERENCE INTERVALS; LYMPHOCYTE SUBSETS; ETHIOPIANS AB OBJECTIVES To define and discuss reference ranges for commonly determined laboratory parameters in healthy adults from southern Tanzania. METHODS A population-based sample of adult volunteers from Mbeya, Tanzania, who were not HIV positive or showing signs and symptoms of other diseases, participated in this study. We enrolled 145 women and 156 men between 19 and 48 years of age to determine clinical chemistry (CC), haematology and lymphocyte immunophenotyping (LIP) parameters using standard laboratory methods. Medians and nonparametric 95% reference ranges for each parameter were determined and compared with reference ranges from the USA, Europe and from other African countries. RESULTS Agreement with ranges from developed countries was poor: for CC values the average concordance was 80.9% and 86.7% with values from two developed countries. Haematology ranges from the USA classified 86.3% of values correctly, whereas ranges from three different sub-Saharan Africa (SSA) sites classified between 82.5% and 94.5% of values correctly. The agreement of LIP reference ranges was 87.5% with values determined in Germany but between 91.7% and 95.8% compared with values determined at other sites in SSA. CONCLUSION Clinical reference ranges determined in developed countries are inadequate for use in SSA. Laboratories in this region should either define their own or use values determined under similar conditions. The ranges reported here are more appropriate for use in SSA than ranges determined in developed countries. C1 [Saathoff, Elmar; Schneider, Philine; Geis, Steffen; Hoelscher, Michael] Klinikum Univ Munchen, Abt Infekt & TopenmMed, Munich, Germany. [Kleinfeldt, Vera; Geis, Steffen; Haule, Dennis; Maboko, Leonard] Mbeya Med Res Programme, Mbeya, Tanzania. [Samky, Eleuter] Reg Med Off, Mbeya, Tanzania. [de Souza, Mark] Henry M Jackson Fdn, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Robb, Merlin] Walter Reed Army Inst Res, US Mil HIV res Program USMHRP, Rockville, MD USA. RP Saathoff, E (reprint author), Klinikum Univ Munchen, Abt Infekt & TopenmMed, Munich, Germany. EM saathoff@lrz.uni-muenchen.de RI Hoelscher, Michael/D-3436-2012 NR 25 TC 36 Z9 37 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD MAY PY 2008 VL 13 IS 5 BP 612 EP 625 DI 10.1111/j.1365-3156.2008.02047.x PG 14 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 289NW UT WOS:000255062200003 PM 18331386 ER PT J AU Manabe, YC Kesavan, AK Lopez-Molina, J Hatem, CL Brooks, M Fujiwara, R Flochstein, K Pitt, MLM Tufariello, J Chan, J McMurray, DN Bishai, WR Dannenberg, AM Mendez, S AF Manabe, Yukari C. Kesavan, Anup K. Lopez-Molina, Javier Hatem, Christine L. Brooks, Megan Fujiwara, Ricardo Flochstein, Karl Pitt, M. Louise M. Tufariello, Joann Chan, John McMurray, David N. Bishai, William R. Dannenberg, Arthur M., Jr. Mendez, Susana TI The aerosol rabbit model of TB latency, reactivation and immune reconstitution inflammatory syndrome SO TUBERCULOSIS LA English DT Article DE tuberculosis; rabbit; animal models; latency; reactivation; IRIS; immune reconstitution ID MYCOBACTERIUM-TUBERCULOSIS INFECTION; TUBERCLE-BACILLI; ANTIRETROVIRAL THERAPY; MICROBIAL PERSISTENCE; ACTIVE TUBERCULOSIS; RISK-FACTORS; DISEASE; GRANULOMAS; TISSUE; LUNG AB The large reservoir of human latent tuberculosis (TB) contributes to the global success of the pathogen, Mycobacterium tuberculosis (Mtb). We sought to test whether aerosol infection of rabbits with Mtb H37Rv could model paucibacillary human latent TB. The lung burden of infection peaked at 5 weeks after aerosol infection followed by host containment of infection that was achieved in all rabbits. One-third of rabbits had at least one caseous granuloma with culturable bacilli at 36 weeks after infection suggesting persistent paucibacillary infection. Corticosteroid-induced immunosuppression initiated after disease containment resulted in reactivation of disease. Seventy-two percent of rabbits had culturable bacilli in the right upper lung lobe homogenates compared to none of the untreated controls. Discontinuation of dexamethasone led to predictable lymphoid recovery, with a proportion of rabbits developing multicentric large caseous granuloma. The development and severity of the immune reconstitution inflammatory syndrome (IRIS) was dependent on the antigen load at the time of immunosuppression and subsequent bacillary replication during corticosteroid-induced immunosuppression. Clinically, many aspects were similar to IRIS in severely immunosuppressed HIV-infected patients who have functional restoration of T cells in response to effective (highly active) antiretroviral therapy. This corticosteroid model is the only animal model of the IRIS. Further study of the rabbit model of TB latency, reactivation and IRIS may be important in understanding the immunopathogenesis of these poorly modeled states as well as for improved diagnostics for specific stages of disease. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Manabe, Yukari C.; Kesavan, Anup K.; Lopez-Molina, Javier; Hatem, Christine L.; Brooks, Megan; Bishai, William R.; Dannenberg, Arthur M., Jr.] Johns Hopkins Univ, Ctr TB Res, Baltimore, MD 21205 USA. [Mendez, Susana] Cornell Vet Coll, James A Baker Inst Anim Hlth, Ithaca, NY 14853 USA. [Flochstein, Karl; Pitt, M. Louise M.] USA, Dept Aerobiol & Prod Evaluat, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Fujiwara, Ricardo] George Washington Univ, Med Ctr, Washington, DC 20037 USA. [McMurray, David N.] Texas A&M Hlth Sci Ctr, Dept Microbiol & Mol Pathogenesis, College Stn, TX 77843 USA. [Tufariello, Joann; Chan, John] Albert Einstein Coll Med, Dept Microbiol, Bronx, NY 10461 USA. [Tufariello, Joann; Chan, John] Albert Einstein Coll Med, Dept Immunol, Bronx, NY 10461 USA. [Tufariello, Joann; Chan, John] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA. RP Manabe, YC (reprint author), Johns Hopkins Univ, Ctr TB Res, 720 Rutland St,Rm 1147B, Baltimore, MD 21205 USA. EM ymanabe@jhmi.edu RI Fujiwara, Ricardo/J-7579-2012 OI Fujiwara, Ricardo/0000-0002-4713-575X FU NHLBI NIH HHS [1R01 HL71554, R01 HL071554] NR 23 TC 51 Z9 54 U1 0 U2 8 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1472-9792 J9 TUBERCULOSIS JI Tuberculosis PD MAY PY 2008 VL 88 IS 3 BP 187 EP 196 DI 10.1016/j.tube.2007.10.006 PG 10 WC Immunology; Microbiology; Respiratory System SC Immunology; Microbiology; Respiratory System GA 305LU UT WOS:000256180700003 PM 18068491 ER PT J AU Mancini, JG Kizer, WS Jones, LA Mora, RV Morey, AF AF Mancini, John G. Kizer, William S. Jones, LeRoy A. Mora, Rafael V. Morey, Allen F. TI Patient satisfaction after dual implantation of inflatable penile and artificial urinary sphincter prostheses SO UROLOGY LA English DT Article ID INCONTINENCE; INCISION; PROSTATECTOMY; OUTCOMES AB OBJECTIVES Since description of the transverse scrotal approach for artificial urinary sphincter (AUS) placement, simultaneous implantation of an inflatable penile prosthesis (IPP) and AUS through a single incision has been shown to constitute safe, efficient, and cost-effective treatment for men plagued by both erectile dysfunction and urinary incontinence. We present patient satisfaction outcomes after simultaneous dual implantation (DI) of an IPP and AUS. METHODS We compared outcomes of postprostatectomy patients who underwent DI to those receiving IPP or AUS alone from 2001 to 2006. Telephone interviews using a standard questionnaire were conducted to evaluate prosthetic functionality, ease of use, and patient satisfaction. RESULTS A total of 95 men were evaluated (31 for IPP alone, 31 for AUS alone, and 33 for DI). Daily pad usage decreased from 4.6 to 0.8 pads per day with AUS alone and 6.1 to 1.3 pads per day with DI. Patients were similarly satisfied with IPP rigidity during inflation and flaccidity during inactivation in both IPP and DI groups (4.1 to 4.4 for rigidity and 3.9 for flaccidity [1 = "unhappy" and 5 = "happy"]). Ease of scrotal pump operation was similar in all groups, as was overall prosthetic satisfaction. Most patients stated that they would recommend the DI procedure to a friend or relative (87% to 94%) or have the procedure done again (77% to 94%). CONCLUSIONS Dual implantation produces encouraging outcomes in patient satisfaction, ease of use and functionality that are similar to those found after placement of either IPP or AUS alone. C1 [Mancini, John G.; Kizer, William S.; Jones, LeRoy A.; Mora, Rafael V.; Morey, Allen F.] Brooke Army Med Ctr, Urol Serv, San Antonio, TX USA. RP Morey, AF (reprint author), Univ Texas SW Med Ctr Dallas, Dept Urol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM allen.morey@utsouthwestern.edu NR 10 TC 15 Z9 15 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD MAY PY 2008 VL 71 IS 5 BP 893 EP 896 DI 10.1016/j.urology.2007.10.018 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 302TJ UT WOS:000255992000043 PM 18374398 ER PT J AU Sterbis, JR Hanly, EJ Herman, BC Marohn, MR Broderick, TJ Shih, SP Harnett, B Doarn, C Schenkman, NS AF Sterbis, Joseph R. Hanly, Eric J. Herman, Barry C. Marohn, Michael R. Broderick, Timothy J. Shih, Samuel P. Harnett, Brett Doarn, Charles Schenkman, Noah S. TI Transcontinental telesurgical nephrectomy using the da Vinci robot in a porcine model SO UROLOGY LA English DT Article ID INITIAL CLINICAL-EXPERIENCE; UROLOGY AB OBJECTIVES Robotic telesurgery has been demonstrated over long distances and offers theoretical benefits to urologic training and the care of patients in remote regions. The multiple arms and three-dimensional vision of the da Vinci robotic system provide a platform conducive to long-distance telementoring and telesurgery. Whereas prior telesurgical efforts have used dedicated lines for information transmission, the public Internet offers a less expensive alternative. It was the intent of this study to test the validity of using the da Vinci system in urologic telesurgery, and to conduct telerobotic nephrectomies using the public Internet. METHODS We performed four right nephrectomies in porcine models using the da Vinci robotic system. Telementoring and telesurgical approaches were used, with resident surgeons operating a console adjacent to the swine, while attending surgeons simultaneously operated a second console at distances of 1300 and 2400 miles from the operating room. RESULTS All four procedures and both telementoring and telesurgical models were successful. Round-trip delays from 450 to 900 ms were demonstrated. Blood loss was minimal, and there were no intraoperative complications. CONCLUSIONS This study represents the first use of the da Vinci Surgical System in urologic telesurgery and the first successful telesurgical nephrectomy in an animal model. C1 [Sterbis, Joseph R.] Walter Reed Army Med Ctr, Urol Serv, Dept Surg, Washington, DC 20307 USA. Johns Hopkins Univ, Dept Surg, Baltimore, MD USA. Univ Cincinnati, Dept Surg, Cincinnati, OH 45267 USA. RP Sterbis, JR (reprint author), Walter Reed Army Med Ctr, Urol Serv, Dept Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM joseph.sterbis@na.amedd.army.mil NR 10 TC 32 Z9 34 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD MAY PY 2008 VL 71 IS 5 BP 971 EP 973 DI 10.1016/j.urology.2007.11.027 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 302TJ UT WOS:000255992000061 PM 18295861 ER PT J AU Amin, A Golarz, S Scanlan, B Hashemi, H Mukherjee, D AF Amin, Asna Golarz, Scott Scanlan, Bradford Hashemi, Homayoun Mukherjee, Dipanker TI Patients requiring dialysis are not at risk of greater complication after carotid endarterectomy SO VASCULAR LA English DT Article DE carotid endarterectomy; hemodialysis ID CHRONIC RENAL-INSUFFICIENCY; SYMPTOMATIC PATIENTS; STENOSIS; ANESTHESIA; TRIAL AB Stroke is a leading cause of disability and the third leading cause of death. Landmark studies have demonstrated that carotid endarterectomy (CEA) reduced the risk of stroke among selected patients with carotid stenosis. Renal insufficiency is a known risk factor for stroke and appears to be an independent risk factor for poor outcome after CEA. Studies have reported high morbidity and mortality after CEA in patients on dialysis. However, our experience has been that patients undergoing dialysis have no greater risk for a poor outcome. This study was a retrospective review of our CEA patients to ascertain our morbidity and mortality results in dialysis patients versus patients not on dialysis. An institutional retrospective chart review of CEAs from January 1999 to December 2007 was conducted. Patients on dialysis at the time of CEA were identified. Their charts were reviewed for complications 30 days after surgery. This was compared with our total experience with CEAs from January 1999 to December 2007. Of the 28 patients undergoing CEA while dialysis dependent, none had complications in the 30-day postoperative period. This compares favorably with the cohort of all CEAs by the same surgeons. In that group, 13 complications were identified (13 of 1,141). Patients undergoing dialysis are at no greater risk for complications when undergoing carotid enclarterectomy than the general population. C1 [Amin, Asna; Golarz, Scott; Scanlan, Bradford] Walter Reed Army Med Ctr, Dept Gen Surg, Washington, DC 20307 USA. [Hashemi, Homayoun; Mukherjee, Dipanker] Inova Fairfax Hosp, Dept Vasc Surg Cardiac Vasc Thorac Surg Associate, Washington, DC USA. [Hashemi, Homayoun; Mukherjee, Dipanker] Inova Fairfax Hosp, Dept Vasc Surg, Washington, DC USA. RP Amin, A (reprint author), Walter Reed Army Med Ctr, Dept Gen Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 16 TC 5 Z9 5 U1 1 U2 1 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 1708-5381 J9 VASCULAR JI Vascular PD MAY-JUN PY 2008 VL 16 IS 3 BP 167 EP 170 DI 10.2310/6670.2008.00029 PG 4 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 337TZ UT WOS:000258459700007 PM 18674466 ER PT J AU Schutzer, SE Schlater, LRK Ronning, CM DeShazer, D Luft, BJ Dunn, JJ Ravel, J Fraser-Liggett, CM Nierman, WC AF Schutzer, Steven E. Schlater, Linda R. K. Ronning, Catherine M. DeShazer, David Luft, Benjamin J. Dunn, John J. Ravel, Jacques Fraser-Liggett, Claire M. Nierman, William C. TI Characterization of Clinically-Attenuated Burkholderia mallei by Whole Genome Sequencing: Candidate Strain for Exclusion from Select Agent Lists SO PLOS ONE LA English DT Article AB Background: Burkholderia mallei is an understudied biothreat agent responsible for glanders which can be lethal in humans and animals. Research with this pathogen has been hampered in part by constraints of Select Agent regulations for safety reasons. Whole genomic sequencing (WGS) is an apt approach to characterize newly discovered or poorly understood microbial pathogens. Methodology/Principal Findings: We performed WGS on a strain of B. mallei, SAVP1, previously pathogenic, that was experimentally infected in 6 equids ( 4 ponies, 1 mule, 1 donkey), natural hosts, for purposes of producing antibodies. Multiple high inocula were used in some cases. Unexpectedly SAVP1 appeared to be avirulent in the ponies and mule, and attenuated in the donkey, but induced antibodies. We determined the genome sequence of SAVP1 and compared it to a strain that was virulent in horses and a human. In comparison, this phenotypic avirulent SAVP1 strain was missing multiple genes including all the animal type III secretory system (T3SS) complex of genes demonstrated to be essential for virulence in mice and hamster models. The loss of these genes in the SAVP1 strain appears to be the consequence of a multiple gene deletion across insertion sequence ( IS) elements in the B. mallei genome. Therefore, the strain by itself is unlikely to revert naturally to its virulent phenotype. There were other genes present in one strain and not the other and vice-versa. Conclusion/Significance: The discovery that this strain of B. mallei was both avirulent in the natural host ponies, and did not possess T3SS associated genes may be fortuitous to advance biodefense research. The deleted virulence-essential T3SS is not likely to be re-acquired naturally. These findings may provide a basis for exclusion of SAVP1 from the Select Agent regulation or at least discussion of what else would be required for exclusion. This exclusion could accelerate research by investigators not possessing BSL-3 facilities and facilitate the production of reagents such as antibodies without the restraints of Select Agent regulation. C1 [Schutzer, Steven E.] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Newark, NJ 07103 USA. [Schlater, Linda R. K.] USDA, Ames, IA USA. [Ronning, Catherine M.; Nierman, William C.] J Craig Venter Inst, Rockville, MD USA. [DeShazer, David] US Army Med Res Inst Infect Dis, Fort Detrick, MD USA. [Luft, Benjamin J.] SUNY Stony Brook, Dept Med, Stony Brook, NY USA. [Dunn, John J.] Brookhaven Natl Lab, Biol Dept, Upton, NY USA. [Ravel, Jacques; Fraser-Liggett, Claire M.] Univ Maryland, Sch Med, Dept Med, Inst Genome Sci, Baltimore, MD USA. [Ravel, Jacques; Fraser-Liggett, Claire M.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Inst Genome Sc, Baltimore, MD USA. [Nierman, William C.] George Washington Univ, Sch Med, Dept Biochem & Mol Biol, Washington, DC USA. RP Schutzer, SE (reprint author), Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, 185 S Orange Ave, Newark, NJ 07103 USA. EM schutzer@umdnj.edu OI Ravel, Jacques/0000-0002-0851-2233; Luft, Benjamin/0000-0001-9008-7004; Fraser, Claire/0000-0003-1462-2428 FU National Institutes of Health [N01-AI30071, U01 AI056480, AI063757] FX Work was funded in part by several grants from the National Institutes of Health (N01-AI30071, U01 AI056480, AI063757). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 8 Z9 9 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 30 PY 2008 VL 3 IS 4 AR e2058 DI 10.1371/journal.pone.0002058 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 381YR UT WOS:000261572300027 PM 18446194 ER PT J AU Hawkins, VN Auliff, A Prajapati, SK Rungsihirunrat, K Hapuarachchi, HC Maestre, A O'Neil, MT Cheng, Q Joshi, H Na-Bangchang, K Sibley, CH AF Hawkins, Vivian N. Auliff, Alyson Prajapati, Surendra Kumar Rungsihirunrat, Kanchana Hapuarachchi, Hapuarachchige C. Maestre, Amanda O'Neil, Michael T. Cheng, Qin Joshi, Hema Na-Bangchang, Kesara Sibley, Carol Hopkins TI Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase SO MALARIA JOURNAL LA English DT Article ID ANTIMALARIAL-DRUG RESISTANCE; MALARIA PARASITES; PYRIMETHAMINE RESISTANCE; FALCIPARUM; GENE; DHFR; IDENTIFICATION; TRANSMISSION; EVOLUTION; SPREAD AB Background: In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populations. Recent work has demonstrated that pyrimethamine-resistance conferring mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) have arisen rarely de novo, but spread widely in Asia and Africa. The origin and spread of mutations in Plasmodium vivax dhfr were assessed by constructing haplotypes based on sequencing dhfr and its flanking regions. Methods: The P. vivax dhfr coding region, 792 bp upstream and 683 bp downstream were amplified and sequenced from 137 contemporary patient isolates from Colombia, India, Indonesia, Papua New Guinea, Sri Lanka, Thailand, and Vanuatu. A repeat motif located 2.6 kb upstream of dhfr was also sequenced from 75 of 137 patient isolates, and mutational relationships among the haplotypes were visualized using the programme Network. Results: Synonymous and non-synonymous single nucleotide polymorphisms (SNPs) within the dhfr coding region were identified, as was the well-documented in-frame insertion/deletion (indel). SNPs were also identified upstream and downstream of dhfr, with an indel and a highly polymorphic repeat region identified upstream of dhfr. The regions flanking dhfr were highly variable. The double mutant (58R/117N) dhfr allele has evolved from several origins, because the 58R is encoded by at least 3 different codons. The triple (58R/61M/117T) and quadruple (57L/61M/117T/173F, 57I/58R/61M/117T and 57L/58R/61M/117T) mutant alleles had at least three independent origins in Thailand, Indonesia, and Papua New Guinea/Vanuatu. Conclusion: It was found that the P. vivax dhfr coding region and its flanking intergenic regions are highly polymorphic and that mutations in P. vivax dhfr that confer antifolate resistance have arisen several times in the Asian region. This contrasts sharply with the selective sweep of rare antifolate resistant alleles observed in the P. falciparum populations in Asia and Africa. The finding of multiple origins of resistance-conferring mutations has important implications for drug policy. C1 [Hawkins, Vivian N.; Sibley, Carol Hopkins] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. [Auliff, Alyson; O'Neil, Michael T.; Cheng, Qin] Australian Army Med Inst, Dept Drug Resistance & Diagnost, Enoggera, Qld, Australia. [Prajapati, Surendra Kumar; Joshi, Hema] Natl Inst Malaria Res, Delhi, India. [Rungsihirunrat, Kanchana] Chulalongkorn Univ, Coll Publ Hlth Sci, Bangkok, Thailand. [Rungsihirunrat, Kanchana] Univ Kelaniya, Fac Med, Ragama, Sri Lanka. [Maestre, Amanda] Univ Antioquia, Grp Malaria, Medellin, Colombia. [O'Neil, Michael T.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Na-Bangchang, Kesara] Thammasat Univ, Fac Allied Hlth Sci, Pathumthanee, Thailand. RP Sibley, CH (reprint author), Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. EM vnh@u.washington.edu; Alyson.Auliff@defence.gov.au; surendramrc@gmail.com; rskanchana@yahoo.com; chandith@lycos.com; aemaestre@quimbaya.udea.edu.co; michael.t.oneil@us.army.mil; Qin.Cheng@defence.gov.au; hema_joshi_mrc@yahoo.com; kesaratmu@yahoo.com; sibley@u.washington.edu FU NIAID NIH HHS [R01 AI055604, AI 55604] NR 30 TC 21 Z9 22 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD APR 28 PY 2008 VL 7 AR 72 DI 10.1186/1475-2875-7-72 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 305BF UT WOS:000256152100003 PM 18442404 ER PT J AU Tehonkova, M Peters, J Sture, S AF Tehonkova, Maria Peters, John Sture, Stein TI A new mixed finite element method for poro-elasticity SO INTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS LA English DT Article DE finite element method; Biot consolidation; porous medium; elasticity; Darcy flow ID BIOTS CONSOLIDATION PROBLEM; LEAST-SQUARES METHOD; LINEAR ELASTICITY; SOLVING PROBLEMS; APPROXIMATIONS; CONVERGENCE AB Development of robust numerical solutions for poro-elasticity is an important and timely issue in modem computational geomechanics. Recently, research in this area has seen a surge in activity, not only because of increased interest in coupled problems relevant to the petroleum industry, but also due to emerging applications of poro-elasticity for modelling problems in biomedical engineering and materials science. In this paper, an original mixed least-squares method for solving Biot consolidation problems is developed. The solution is obtained via minimization of a least-squares functional, based upon the equations of equilibrium, the equations of continuity and weak forms of the constitutive relationships for elasticity and Darcy flow. The formulation involves four separate categories of unknowns: displacements, stresses, fluid pressures and velocities. Each of these unknowns is approximated by linear continuous functions. The mathematical formulation is implemented in an original computer program, written from scratch and using object-oriented logic. The performance of the method is tested on one- and two-dimensional classical problems in poro-elasticity. The numerical experiments suggest the same rates of convergence for all four types of variables, when the same interpolation spaces are used. The continuous linear triangles show the same rates of convergence for both compressible and entirely incompressible elastic solids. This mixed formulation results in non-oscillating fluid pressures over entire domain for different moments of time. The method appears to be naturally stable, without any need of additional stabilization terms with mesh-dependent parameters. Copyright (c) 2007 John Wiley & Sons, Ltd. C1 [Peters, John] USA, Engn Res & Dev Ctr, Vicksburg, MS 39190 USA. [Sture, Stein] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. RP Tehonkova, M (reprint author), 9009 Great Hills Trail,Suite 224, Austin, TX 78759 USA. EM parashke@bechtel.colorado.edu NR 34 TC 2 Z9 2 U1 1 U2 10 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0363-9061 J9 INT J NUMER ANAL MET JI Int. J. Numer. Anal. Methods Geomech. PD APR 25 PY 2008 VL 32 IS 6 BP 579 EP 606 DI 10.1002/nag.630 PG 28 WC Engineering, Geological; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA 297FT UT WOS:000255603200001 ER PT J AU Grujicic, M Bell, WC Thompson, LL Koudela, KL Cheeseman, BA AF Grujicic, M. Bell, W. C. Thompson, L. L. Koudela, K. L. Cheeseman, B. A. TI Ballistic-protection performance of carbon-nanotube-doped poly-vinyl-ester-epoxy matrix composite armor reinforced with E-glass fiber mats SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE vinyl ester epoxy; carbon nanotubes; composite materials; armor ID FUNCTIONALIZATION; ROPES; SOLUBILIZATION; WOVEN AB In the present work, a material model development approach and transient non-linear dynamics simulations of the projectile/armor interactions are employed to explore the role of multi-walled carbon-nanotube (MWCNT) reinforcements in improving the ballistic-protection performance of polyvinyl-ester-epoxy matrix (PVEE)/E-glass fiber matrix reinforced laminate armor. Two different architectures of the composite-laminate armor are considered: (a) a hybrid armor consisting of a 100 mu m-thick high MWCNT-content PVEE-matrix MWCNT-reinforced lamina sandwiched between two PVEE-matrix/E-glass mat reinforced laminas and (b) a monolithic E-glass mat reinforced composite laminate with a low MWCNT-content MWCNT-doped PVEE-matrix. The projectile/armor interaction simulation results show that both armor architectures yield a minimal (similar to 6%) increase in the ballistic-protection as measured by the armor V50, a velocity at which the probability of armor penetration by a given fragment is 50%. The results obtained are rationalized using a simple analysis of the effect of MWCNTs on the in-plane and the through-the-thickness properties of the armor. (c) 2007 Elsevier B.V. All rights reserved. C1 [Grujicic, M.; Bell, W. C.; Thompson, L. L.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Koudela, K. L.] Penn State Univ, Appl Res Lab, University Pk, PA 16802 USA. [Cheeseman, B. A.] Army Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu NR 27 TC 19 Z9 20 U1 2 U2 24 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD APR 25 PY 2008 VL 479 IS 1-2 BP 10 EP 22 DI 10.1016/j.msea.2007.06.013 PG 13 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 292HE UT WOS:000255256300002 ER PT J AU Wang, CS Zheng, JY Zhao, L Rastogi, VK Shah, SS DeFrank, JJ Leblanc, RM AF Wang, Chengshan Zheng, Jiayin Zhao, Liang Rastogi, Vipin K. Shah, Saumil S. DeFrank, Joseph J. Leblanc, Roger M. TI Infrared reflection-absorption Spectroscopy and polarization-modulated infrared reflection-absorption Spectroscopy studies of the organophosphorus acid anhydrolase Langmuir monolayer SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID AIR-WATER-INTERFACE; MOLECULAR RECOGNITION; AIR/WATER INTERFACE; SECONDARY STRUCTURE; BLODGETT-FILMS; QUANTUM DOTS; AMIDE I; HYDROLASE; PARAOXON; ORIENTATION AB The secondary structure of the organophosphorus acid anhydrolase (OPAA) Langmuir monolayer in the absence and presence of diisopropylfluorophosphate (DFP) in the subphase was studied by infrared reflection-absorption spectroscopy (IRRAS) and polarization-modulated IRRAS (PM-IRRAS). The results of both the IRRAS and the PM-IRRAS indicated that the a-helix and the beta-sheet conformations in OPAA were parallel to the air(-)water interface at a surface pressure of 0 mN center dot m(-1) in the absence of DFP in the subphase. When the surface pressure increased, the alpha-helix and the beta-sheet conformations became tilted. When DFP was added to the subphase at a concentration of 1.1 x 10(-5) M, the alpha-helix conformation of OPAA was still parallel to the air-water interface, whereas the beta-sheet conformation was perpendicular at 0 mN center dot m(-1). The orientations of both the a-helix and the beta-sheet conformations did not change with the increase of surface pressure. The shape of OPAA molecules is supposed to be elliptic, and the long axis of OPAA was parallel to the air-water interface in the absence of DFP in the subphase, whereas the long axis became perpendicular in the presence of DFP. This result explains the decrease of the limiting molecular area of the OPAA Langmuir monolayer when DFP was dissolved in the subphase. C1 [Wang, Chengshan; Zheng, Jiayin; Zhao, Liang; Leblanc, Roger M.] Univ Miami, Dept Chem, Coral Gables, FL 33146 USA. [Rastogi, Vipin K.; Shah, Saumil S.; DeFrank, Joseph J.] USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Leblanc, RM (reprint author), Univ Miami, Dept Chem, Coral Gables, FL 33146 USA. EM rml@miami.edu NR 42 TC 12 Z9 12 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD APR 24 PY 2008 VL 112 IS 16 BP 5250 EP 5256 DI 10.1021/jp709591e PG 7 WC Chemistry, Physical SC Chemistry GA 290EA UT WOS:000255104900050 PM 18373370 ER PT J AU Kester, KE Cummings, JF Ockenhouse, CF Nielsen, R Hall, BT Gordon, DM Schwenk, RJ Krzych, U Holland, CA Richmond, G Dowler, MG Williams, J Wirtz, RA Tornieporth, N Vigneron, L Delchambre, M Demoitie, MA Ballou, WR Cohen, J Heppner, DG AF Kester, Kent E. Cummings, James F. Ockenhouse, Christian F. Nielsen, Robin Hall, B. Ted Gordon, Daniel M. Schwenk, Robert J. Krzych, Urszula Holland, Carolyn A. Richmond, Gregory Dowler, Megan G. Williams, Jackie Wirtz, Robert A. Tornieporth, Nadia Vigneron, Laurence Delchambre, Martine Demoitie, Marie-Ange Ballou, W. Ripley Cohen, Joe Heppner, D. Gray, Jr. TI Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naive adults at the Walter Reed Army Institute of Research SO VACCINE LA English DT Article DE RTS,S; malaria; vaccine; falciparum; adjuvant system; AS02; circumsporozoite protein; hepatitis B; antibody; clinical trials; rapid immunization; IFN-gamma; ELISPOT ID PLASMODIUM-FALCIPARUM MALARIA; CIRCUMSPOROZOITE PROTEIN VACCINE; RANDOMIZED CONTROLLED-TRIAL; DRUG-RESISTANT MALARIA; EFFICACY; IMMUNOGENICITY; PROTECTION; SAFETY; INFECTION; CORRELATE AB Background: Immunization with RTS,S/AS02 consistently protects some vaccinees against malaria infection in experimental challenges and in field trials. A brief immunization schedule against falciparum malaria would be compatible with the Expanded Programme on Immunization, or in combination with other prevention measures, interrupt epidemic malaria or protect individuals upon sudden travel to an endemic area. Methods: We conducted an open label, Phase 2a trial of two different full dose schedules of RTS,S/AS02 in 40 healthy malaria-naive adults. Cohort 1 (n=20) was immunized on a 0, 1, and 3 month schedule and Cohort 2 (n = 20) on a 0, 7, and 28 day schedule. Three weeks later, 38 vaccinees and 12 unimmunized infectivity controls underwent malaria challenge. Results: Both regimens had a good safety and tolerability profile. Peak GMCs of antibody to the circumsporozoite protein (CSP) were similar in Cohort 1 (78 mu g/mL; 95% CI: 45-134) and Cohort 2 (65 mu g/mL; 95% CI: 40-104). Vaccine efficacy for Cohort 1 was 45% (95% CI: 18-62%) and for Cohort 2, 39% (95% CI: 11-56%). Protected volunteers had a higher GMC of anti-CSP antibody (114 mu g/mL) than did volunteers with a 2-day delay (70 mu g/mL) or no delay (30 mu g/mL) in the time to onset of parasitemia (Kruskal-Wallis, p = 0.019). A trend was seen for higher CSP-specific IFN-gamma responses in PBMC from protected volunteers only in Cohort 1, but not in Cohort 2, for ex vivo and for cultured ELISPOT assays. Conclusion: In malaria-naive adults, the efficacy of three-dose RTS,S/AS02 regimens on either a 0, 1, and 3 month schedule or an abbreviated 0, 7, and 28 day schedule was not discernibly different from two previously reported trials of two-dose regimens given at 0, 1 month that conferred 47% (95% CI: - 19 to 76%) protection and in another trial 42% (95% CI: 5-63%). A strong association of CSP-specific antibody with protection against malaria challenge is observed and confirms similar observations made in other studies. Subsequent trials of adjuvanted RTS,S in African children and infants on a 0, 1, and 2 month schedule have demonstrated a favorable safety and efficacy profile. Published by Elsevier Ltd. C1 [Kester, Kent E.; Cummings, James F.; Ockenhouse, Christian F.; Nielsen, Robin; Hall, B. Ted; Gordon, Daniel M.; Schwenk, Robert J.; Krzych, Urszula; Holland, Carolyn A.; Richmond, Gregory; Dowler, Megan G.; Williams, Jackie; Heppner, D. Gray, Jr.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Wirtz, Robert A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Tornieporth, Nadia; Vigneron, Laurence; Delchambre, Martine; Demoitie, Marie-Ange; Ballou, W. Ripley; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. RP Kester, KE (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM kent.kester@us.army.mil RI Kester, Kent/A-2114-2011; Holland, Carolyn/B-7880-2011; Nielsen, Robin/B-6811-2011 OI Kester, Kent/0000-0002-5056-0802; NR 29 TC 81 Z9 83 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD APR 24 PY 2008 VL 26 IS 18 BP 2191 EP 2202 DI 10.1016/j.vaccine.2008.02.048 PG 12 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 299SU UT WOS:000255776100004 PM 18387719 ER PT J AU Loftis, AD Mixson, TR Stromdahl, EY Yabsley, MJ Garrison, LE Williamson, PC Fitak, RR Fuerst, PA Kelly, DJ Blount, KW AF Loftis, Amanda D. Mixson, Tonya R. Stromdahl, Ellen Y. Yabsley, Michael J. Garrison, Laurel E. Williamson, Phillip C. Fitak, Robert R. Fuerst, Paul A. Kelly, Daryl J. Blount, Keith W. TI Geographic distribution and genetic diversity of the Ehrlichia sp from Panola Mountain in Amblyomma americanum SO BMC INFECTIOUS DISEASES LA English DT Article ID COWDRIA-RUMINANTIUM; CENTRAL TEXAS; HEARTWATER; INFECTION; PREVALENCE; IXODIDAE; ACARI; TICKS; MAINLAND; SEQUENCE AB Background: A novel Ehrlichia, closely related to Ehrlichia ruminantium, was recently discovered from Panola Mountain State Park, GA, USA. We conducted a study to determine if this agent was recently introduced into the United States. Methods: We developed a sensitive PCR assay based on the conserved gltA (citrate synthase) gene and tested DNA samples extracted from 1964 field-collected and 1835 human-biting Amblyomma americanum from 23 eastern states of the USA. Results: The novel agent was detected in 36 ticks collected from 10 states between 1998 and 2006. Infected ticks were collected both from vegetation (n = 14, 0.7%) and from humans (n = 22, 1.2%). Fragments of the conserved gltA gene and the variable map1 gene were sequenced from positive samples. Two distinct clades, with 10.5% nucleic acid divergence over the 730 bp map1 sequence, were identified. Conclusion: These data suggest that the Panola Mountain Ehrlichia was not recently introduced to the United States; this agent has an extensive distribution throughout the range of its tick vector, has been present in some locations for several years, and displays genetic variability. Furthermore, people in several states were exposed to this agent through the bite of infected ticks, underscoring the potential public health risk of this emerging ehrlichiosis. C1 [Loftis, Amanda D.; Mixson, Tonya R.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Stromdahl, Ellen Y.] USA, Ctr Hlth Promot & Prevent Med, Entomol Sci Program, Aberdeen Proving Ground, MD 21010 USA. [Yabsley, Michael J.] Univ Georgia, Daniel B Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. [Yabsley, Michael J.] Univ Georgia, SE Cooperat Wildlife Dis Study, Dept Populat Hlth, Coll Vet Med, Athens, GA 30602 USA. [Garrison, Laurel E.] Georgia Div Publ Hlth, Atlanta, GA 30303 USA. [Williamson, Phillip C.] Univ N Texas, Hlth Sci Ctr, DNA Ident Lab, Dept Pathol & Human Identificat, Ft Worth, TX 76107 USA. [Fitak, Robert R.; Fuerst, Paul A.; Kelly, Daryl J.] Ohio State Univ, Dept Ecol Evolut & Organismal Biol, Columbus, OH 43210 USA. [Blount, Keith W.] USAF, Res Lab, Brooks City Base, Brooks AFB, TX 78235 USA. RP Loftis, AD (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM adloftis@gmail.com; zdy0@cdc.gov; ellen.stromdahl@us.army.mil; myabsley@vet.uga.edu; legarrison@dhr.state.ga.us; phwilliam@hsc.unt.edu; fitak.2@osu.edu; fuerst.1@osu.edu; kelly.350@osu.edu; keith.blount@brooks.af.mil NR 20 TC 21 Z9 21 U1 4 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD APR 23 PY 2008 VL 8 AR 54 DI 10.1186/1471-2334-8-54 PG 7 WC Infectious Diseases SC Infectious Diseases GA 308DK UT WOS:000256368300002 PM 18433500 ER PT J AU Hackley, JC Demaree, JD Gougousi, T AF Hackley, Justin C. Demaree, J. Derek Gougousi, Theodosia TI Interface of atomic layer deposited HfO(2) films on GaAs (100) surfaces SO APPLIED PHYSICS LETTERS LA English DT Article ID KAPPA GATE DIELECTRICS; GAAS; PASSIVATION AB HfO(2) films have been deposited by using a tetrakis(dimethylamino)hafnium/H(2)O atomic layer deposition (ALD) process on GaAs. X-ray photoelectron spectroscopy measurements show that the HF and NH(4)OH predeposition surface treatment results in efficient removal of the Ga and As native oxides. No interface oxidation is detected after 15 cycles of HfO(2) ALD implying effective passivation of the GaAs surface. Spectroscopic ellipsometry confirms linear growth at 1.0 A/cycle on both starting surfaces, while Rutherford backscattering spectrometry indicates steady-state coverage after about 10 ALD cycles. For films grown on native oxide GaAs, complete removal of the As oxide is observed after 20 ALD cycles. (c) 2008 American Institute of Physics. C1 [Hackley, Justin C.; Gougousi, Theodosia] Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA. [Demaree, J. Derek] USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Hackley, JC (reprint author), Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA. EM gougousi@umbc.edu RI Gougousi, Theodosia/C-8156-2014 NR 15 TC 34 Z9 34 U1 0 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 21 PY 2008 VL 92 IS 16 AR 162902 DI 10.1063/1.2908223 PG 3 WC Physics, Applied SC Physics GA 295DV UT WOS:000255456100051 ER PT J AU Hooper, J Cooper, VR Thonhauser, T Romero, NA Zerilli, F Langreth, DC AF Hooper, Joe Cooper, Valentino R. Thonhauser, Timo Romero, Nichols A. Zerilli, Frank Langreth, David C. TI Predicting C-H/pi interactions with nonlocal density functional theory SO CHEMPHYSCHEM LA English DT Article DE ab initio calculations; aromatic compounds correlation energy; density functional calculations; hydrogen bonding ID GENERALIZED GRADIENT APPROXIMATION; CH/PI-INTERACTION; BENZENE; METHANE; MODEL; MAGNITUDE; COMPLEXES; PROTEINS AB We examine the performance of a recently developed nonlocal density functional in predicting a model noncovalent interaction, namely the weak bond between an aromatic T system and an aliphatic C-H group. The new functional is a significant improvement over traditional density functionals, providing results which compare favorably to high-level quantum-chemistry techniques, but at considerably lower computational cost. Interaction energies in several model C-H/pi systems ore in good general agreement with coupled-cluster calculations, though equilibrium distances are consistently overpredicted when using the revPBE functional for exchange. The new functional predicts changes in energy upon addition of halogen substituents correctly. C1 [Hooper, Joe; Zerilli, Frank] USN, Ctr Surface Warfare, Indian Head, MD 20640 USA. [Cooper, Valentino R.; Thonhauser, Timo; Langreth, David C.] Rutgers State Univ, Dept Phys & Astron, Piscataway, NJ 08854 USA. [Romero, Nichols A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Hooper, J (reprint author), USN, Ctr Surface Warfare, Indian Head, MD 20640 USA. EM joseph.p.hooper@navy.mil RI Cooper, Valentino /A-2070-2012 OI Cooper, Valentino /0000-0001-6714-4410 NR 38 TC 34 Z9 34 U1 0 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1439-4235 EI 1439-7641 J9 CHEMPHYSCHEM JI ChemPhysChem PD APR 21 PY 2008 VL 9 IS 6 BP 891 EP 895 DI 10.1002/cphc.200700715 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 298RF UT WOS:000255704100012 PM 18383059 ER PT J AU Lehman, RA Dmitriev, AE Helgeson, MD Sasso, RC Kuklo, TR Riew, KD AF Lehman, Ronald A., Jr. Dmitriev, Anton E. Helgeson, Melvin D. Sasso, Rick C. Kuklo, Timothy R. Riew, K. Daniel TI Salvage of C2 pedicle and pars screws using the intralaminar technique - A biomechanical analysis SO SPINE LA English DT Article DE intralaminar screw; atlantoaxial fixation; axis; biomechanics; atlantoaxial instability; translaminar screw ID ATLANTOAXIAL FIXATION; C1-C2 FUSION; POSTERIOR; ANTERIOR AB Study Design. Human cadaveric biomechanical analysis. Objective. The purpose of this study is to evaluate the ability of using 1 of the remaining 2 methods of instrumenting C2, should the initial method fail. Summary of Background Data. Although 3 different methods of C2 fixation ( pedicle, pars, and laminar screws) are possible, occasionally an attempt at screw insertion fails. In such cases, the surgeon needs a viable alternative to salvage/obtain fixation to obviate the need to instrument an additional motion segment. Methods. Eleven fresh-frozen cadaveric specimens (Occ-C4) were DEXA scanned for bone mineral density. On the left side, pedicle screws were first inserted, then pulled out. Then, "salvage" pars screws were inserted, then pulled-out, followed by laminar screws. On the right, a similar sequence was repeated, except that a pars screw was followed by a pedicle screw, then a laminar screw. All screws were placed by experienced cervical spine surgeons. Insertional torque ( IT) was measured in Newton-meters (Nm). Tensile loading to failure was performed "in-line" with the screw axis at a rate of 0.25 mm/s using a MTS 858 MiniBionix II System with data recorded as peak pull-out strength (POS) in newtons "N". Results. Pedicle screws generated statistically greater IT and POS than other techniques as the initial fixation type (P < 0.0001). Similar trends were observed with transpedicular fixation as a salvage procedure ( P > 0.05). Laminar screws yielded consistently higher POS values than pars fixation when applied in a salvage scenario ( POS range: LS = 146-707 N; PrS = 8-548 N); however, high standard deviation precluded statistical significance ( P > 0.05). Significant predictive relationship was established between IT and POS for all screws using Pearson correlation coefficient and bivariate linear regression analysis (r = 0.75 and r(2) = 0.511, respectively; P < 0.01). Conclusion. Our results suggest that pedicle screws provide the strongest fixation for both initial and salvage applications. If they should fail, lamina screws appear to provide stronger and more reproducible fixation than pars screws. C1 [Lehman, Ronald A., Jr.; Dmitriev, Anton E.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Spine Res Lab, Washington, DC 20307 USA. [Helgeson, Melvin D.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC 20307 USA. [Sasso, Rick C.] Indiana Univ, Sch Med, Indiana Spine Grp, Indianapolis, IN USA. [Kuklo, Timothy R.; Riew, K. Daniel] Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA. RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, 1528 Blue Meadow Rd, Potomac, MD 20854 USA. EM armyspine@yahoo.com NR 16 TC 32 Z9 34 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD APR 20 PY 2008 VL 33 IS 9 BP 960 EP 965 DI 10.1097/BRS.0b013e31816c915b PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 292TZ UT WOS:000255290300005 PM 18427316 ER PT J AU Imai, Y Kuba, K Neely, GG Yaghubian-Malhami, R Perkmann, T van Loo, G Ermolaeva, M Veldhuizen, R Leung, YHC Wang, HL Liu, HL Sun, Y Pasparakis, M Kopf, M Mech, C Bavari, S Peiris, JSM Slutsky, AS Akira, S Hultqvist, M Holmdahl, R Nicholls, J Jiang, CY Binder, CJ Penninger, JM AF Imai, Yumiko Kuba, Keiji Neely, G. Greg Yaghubian-Malhami, Rubina Perkmann, Thomas van Loo, Geert Ermolaeva, Maria Veldhuizen, Ruud Leung, Y. H. Connie Wang, Hongliang Liu, Haolin Sun, Yang Pasparakis, Manolis Kopf, Manfred Mech, Christin Bavari, Sina Peiris, J. S. Malik Slutsky, Arthur S. Akira, Shizuo Hultqvist, Malin Holmdahl, Rikard Nicholls, John Jiang, Chengyu Binder, Christoph J. Penninger, Josef M. TI Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury SO CELL LA English DT Article ID RESPIRATORY-DISTRESS-SYNDROME; LOW-DENSITY-LIPOPROTEIN; 1918 PANDEMIC VIRUS; FACTOR-KAPPA-B; OXIDIZED PHOSPHOLIPIDS; TRANSCRIPTION FACTORS; PULMONARY SURFACTANT; APOLIPOPROTEIN-E; APOPTOTIC CELLS; SYNCYTIAL VIRUS AB Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI). We show that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI. The oxidized phospholipid (OxPL) OxPAPC was identified to induce lung injury and cytokine production by lung macrophages via TLR4-TRIF. We observed OxPL production in the lungs of humans and animals infected with SARS, Anthrax, or H5N1. Pulmonary challenge with an inactivated H5N1 avian influenza virus rapidly induces ALI and OxPL formation in mice. Loss of TLR4 or TRIF expression protects mice from H5N1-induced ALI. Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI. C1 [Kuba, Keiji] Tokyo Med & Dent Univ, Med Res Inst, Chiyoda Ku, Tokyo 1010062, Japan. [Perkmann, Thomas; Binder, Christoph J.] Med Univ Vienna, Inst Med & Chem Lab Diagnost, A-1090 Vienna, Austria. [Perkmann, Thomas; Binder, Christoph J.] Austrian Acad Sci, CeMM, Res Ctr Mol Med, A-1090 Vienna, Austria. [van Loo, Geert; Ermolaeva, Maria; Pasparakis, Manolis] European Mol Biol Lab, Mouse Biol Unit, I-00016 Monterotondo, Italy. [Ermolaeva, Maria; Pasparakis, Manolis] Univ Cologne, Inst Genet, D-50674 Cologne, Germany. [Veldhuizen, Ruud] Univ Western Ontario, Lawson Hlth Res Inst, Dept Med, London, ON N6A 4V2, Canada. [Veldhuizen, Ruud] Univ Western Ontario, Lawson Hlth Res Inst, Dept Physiol & Pharmacol, London, ON N6A 4V2, Canada. [Nicholls, John] Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China. [Leung, Y. H. Connie; Peiris, J. S. Malik] Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China. [Wang, Hongliang; Liu, Haolin; Sun, Yang; Jiang, Chengyu] Peking Union Med Coll, Natl Key Lab Med Mol Biol, Sch Basic Med, Beijing 100005, Peoples R China. [Wang, Hongliang; Liu, Haolin; Sun, Yang; Jiang, Chengyu] Chinese Acad Med Sci, Beijing 100005, Peoples R China. [Kopf, Manfred] Swiss Fed Inst Technol, CH-8952 Zurich, Switzerland. [Mech, Christin; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21701 USA. [Slutsky, Arthur S.] Univ Toronto, Interdepartmental Div Crit Care Med, Toronto, ON M5B 1W8, Canada. [Slutsky, Arthur S.] Univ Toronto, Dept Crit Care, St Michaels Hosp, Toronto, ON M5B 1W8, Canada. [Akira, Shizuo] Osaka Univ, Dept Host Def, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan. [Hultqvist, Malin; Holmdahl, Rikard] BMC, Med Inflammat Res, Lund, Sweden. [Hultqvist, Malin; Holmdahl, Rikard] Karolinska Inst, Med Inflammat Res, MBB, Stockholm, Sweden. [Imai, Yumiko; Kuba, Keiji; Neely, G. Greg; Yaghubian-Malhami, Rubina; Penninger, Josef M.] Austrian Acad Sci, IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria. RP Imai, Y (reprint author), Akita Univ, Sch Med, Global COE Program, Akita 0108543, Japan. EM imai@med.akita-u.ac.jp; josef.penninger@imba.oeaw.ac.at RI van Loo, Geert/C-1505-2009; Peiris, Joseph/C-4380-2009; Leung, Connie/C-4600-2009; Akira, Shizuo/C-3134-2009; neely, graham/A-6511-2011; Penninger, Josef/I-6860-2013; Perkmann, Thomas/F-3074-2012; Sun, Yang/B-2495-2016; OI Pasparakis, Manolis/0000-0002-9870-0966; Penninger, Josef/0000-0002-8194-3777; Sun, Yang/0000-0002-1463-689X; Binder, Christoph J./0000-0001-8313-7050; Perkmann, Thomas/0000-0002-7976-0285 NR 51 TC 477 Z9 516 U1 16 U2 92 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0092-8674 J9 CELL JI Cell PD APR 18 PY 2008 VL 133 IS 2 BP 235 EP 249 DI 10.1016/j.cell.2008.02.043 PG 15 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 289JY UT WOS:000255052000014 PM 18423196 ER PT J AU Taylor, AJ AF Taylor, Allen J. TI Evidence to support aggressive management of high-density lipoprotein cholesterol: Implications of recent imaging trials SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY-DISEASE; EXTENDED-RELEASE NIACIN; FOLLOW-UP; ATHEROSCLEROSIS PROGRESSION; INTRAVASCULAR ULTRASOUND; MYOCARDIAL-INFARCTION; COLESTIPOL-NIACIN; LOWERING THERAPY; CLINICAL EVENTS AB High-density lipoprotein (HDL), is a "regression particle" based on its unique lipid particle biology. This unique property predicts that, in theory, therapies that raise HDL cholesterol should be able to induce regression of atherosclerosis. Presently, the principle pharmacotherapy for increasing HDL cholesterol is niacin. Niacin has been shown to regress atherosclerosis when used as monotherapy, in combination with a statin, and in combination with nonstatin therapies (including cholesterol-binding resins) and fibrates. Insights into the atherosclerosis benefits of combination lipid-lowering therapy with niacin have come from imaging studies utilizing quantitative coronary angiography, carotid ultrasound, and intravascular ultrasound showing modest inverse correlations between the extent of HDL increase and atherosclerosis regression. Recent adverse atherosclerosis and clinical effects seen with cholesterol ester transfer protein inhibition indicate that HDL-raising effects alone are insufficient to predict clinical benefit of new HDL therapies. Thus, although clinical trial evidence is necessary to understand the full scope of the safety and efficacy profile of novel HDL therapeutics, atherosclerosis imaging will be an important component of preclinical testing of these agents as they emerge and in head-to-head testing of treatment strategies. (C) 2008 Elsevier Inc. All rights reserved. C1 USA, Walter Reed Army Med Ctr, Dept Med, Serv Cardiol, Washington, DC 20307 USA. RP Taylor, AJ (reprint author), USA, Walter Reed Army Med Ctr, Dept Med, Serv Cardiol, 6900 Georgia Ave NW,Bldg 2,Room 4A34, Washington, DC 20307 USA. EM allen.taylor@na.amedd.army.mil NR 25 TC 5 Z9 5 U1 0 U2 2 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 EI 1879-1913 J9 AM J CARDIOL JI Am. J. Cardiol. PD APR 17 PY 2008 VL 101 IS 8A SU S BP 36B EP 43B DI 10.1016/j.amjcard.2008.02.030 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 288TU UT WOS:000255009500007 PM 18375240 ER PT J AU Ciobanu, M Taylor, DE Wilburn, JP Cliffel, DE AF Ciobanu, Madalina Taylor, Dale E., Jr. Wilburn, Jeremy P. Cliffel, David E. TI Glucose and lactate biosensors for scanning electrochemical microscopy imaging of single live cells SO ANALYTICAL CHEMISTRY LA English DT Article ID HUMAN BREAST CELLS; CONSTANT-DISTANCE-MODE; LIVING CELLS; RESPIRATORY ACTIVITY; MEMBRANE-TRANSPORT; PLASMA-MEMBRANE; TIP; MICROELECTRODES; MICROPHYSIOMETER; ACIDIFICATION AB We have developed glucose and lactate ultramicroelectrode (UME) biosensors based on glucose oxidase and lactate oxidase (with enzymes immobilized onto Pt UMEs by either electropolymerization or casting) for scanning electrochemical microscopy (SECM) and have determined their sensitivity to glucose and lactate, respectively. The results of our evaluations reveal different advantages for sensors constructed by each method: improved sensitivity and shorter manufacturing time for hand-casting, and increased reproducibility for electropolymerization. We have acquired amperometric approach curves (ACs) for each type of manufactured biosensor UME, and these ACs can be used as a means of positioning the UME above a substrate at a known distance. We have used the glucose biosensor UMEs to record profiles of glucose uptake above individual fibroblasts. Likewise, we have employed the lactate biosensor UMEs for recording the lactate production above single cancer cells with the SECM. We also show that oxygen respiration profiles for single cancer cells do not mimic cell topography, but are rather more convoluted, with a higher respiration activity observed at the points where the cell touches the Petri dish. These UME biosensors, along with the application of others already described in the literature, could prove to be powerful tools for mapping metabolic analytes, such as glucose, lactate, and oxygen, in single cancer cells. C1 [Ciobanu, Madalina; Wilburn, Jeremy P.; Cliffel, David E.] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA. [Taylor, Dale E., Jr.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Cliffel, DE (reprint author), Vanderbilt Univ, Dept Chem, Box 1583, Nashville, TN 37235 USA. EM d.cliffel@vanderbilt.edu FU NCI NIH HHS [U54 CA113007]; NIAID NIH HHS [U01 AI061223, U01 AI061223-05] NR 52 TC 44 Z9 45 U1 2 U2 38 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD APR 15 PY 2008 VL 80 IS 8 BP 2717 EP 2727 DI 10.1021/ac7021184 PG 11 WC Chemistry, Analytical SC Chemistry GA 288EN UT WOS:000254969100010 PM 18345647 ER PT J AU Alexander, TA AF Alexander, Troy A. TI Development of methodology based on commercialized SERS-active substrates for rapid discrimination of Poxviridae virions SO ANALYTICAL CHEMISTRY LA English DT Article ID ENHANCED RAMAN-SCATTERING; SINGLE-MOLECULE; SMALLPOX-VIRUS; SPECTROSCOPY; PCR; IDENTIFICATION; NANOPARTICLE; MANAGEMENT; MONKEYPOX; ARRAYS AB Surface-enhanced Raman spectroscopy (SERS) can be made an attractive approach for identification of Raman-active compounds and biological materials (i.e., toxins, viruses, or intact bacterial cells/spores) through development of reproducible, spatially uniform SERS-active substrates. Recently, reproducible (from substrate-to-substrate), spatially homogeneous (over large areas) SERS-active substrates have been commercialized and are now available in the marketplace. We have utilized these patterned surfaces to acquire SERS, spectral signatures of intact bovine papular stomatitis, pseudocowpox, and Yaba monkey tumor viruses. Salient spectral signature features make it possible to discriminate among these genetically distinct Poxviridae-Chordopoxvirinae virions. In addition, partial least-squares, a multivariate calibration method, has been used to develop personal computer-borne algorithms useful for classification of unknown Parapoxvirus (e.g., bovine papular stomatitis virus and pseudocowpox virus) samples based solely on SERS spectral. signatures. To our knowledge, this is the first report detailing application of these commercial-off-the-shelf (COTS) SERS-active substrates to identification of intact poxviruses. C1 USA, Res Lab, Sensors & Electron Devices Directorate,AMSRD ARL, Photon Integrat Branch,Radiometr Sensor Dev & App, Adelphi, MD 20783 USA. RP Alexander, TA (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate,AMSRD ARL, Photon Integrat Branch,Radiometr Sensor Dev & App, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM troy.a.alexander1@us.army.mil NR 46 TC 32 Z9 34 U1 3 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD APR 15 PY 2008 VL 80 IS 8 BP 2817 EP 2825 DI 10.1021/ac702464w PG 9 WC Chemistry, Analytical SC Chemistry GA 288EN UT WOS:000254969100023 PM 18303918 ER PT J AU Cicci, DA Qualls, C Landingham, G AF Cicci, D. A. Qualls, C. Landingham, G. TI Two-body missile separation dynamics SO APPLIED MATHEMATICS AND COMPUTATION LA English DT Article DE missile separation dynamics; missile stage separation; missile flight dynamics AB The dynamics of the separation of a two-body missile has been investigated. This missile consists of an outer boost vehicle and an inner center body vehicle. Upon completion of the boost phase the two bodies separate as a result of differing aerodynamic loads applied to each body and the thrust from a sustainer motor contained within the center body. Through simulation, the separation event was evaluated for interaction between the two bodies as a function of flight-path-angle, interstage pressure, sustainer motor thrusting force, thrust misalignment angles, and radial clearance. The impact and friction forces created by any interaction were evaluated and their effects on the separation event were quantified. The flight characteristics of the center body after the separation event were also calculated for use in determination of the missile flight pro. le. Finally, recommendations are made regarding the design and performance conditions for the specific two-body missile addressed in this study. (C) 2007 Elsevier Inc. All rights reserved. C1 [Cicci, D. A.; Qualls, C.] Auburn Univ, Dept Aerosp Engn, Auburn, AL 36849 USA. [Landingham, G.] USA, Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35808 USA. RP Cicci, DA (reprint author), Auburn Univ, Dept Aerosp Engn, 211 Aerosp Engn Bldg, Auburn, AL 36849 USA. EM dcicci@eng.auburn.edu NR 4 TC 1 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0096-3003 J9 APPL MATH COMPUT JI Appl. Math. Comput. PD APR 15 PY 2008 VL 198 IS 1 BP 44 EP 58 DI 10.1016/j.amc.2007.08.023 PG 15 WC Mathematics, Applied SC Mathematics GA 277ZX UT WOS:000254254300005 ER PT J AU Purdue, MP Graubard, BI Chanock, SJ Rubertone, MV Erickson, RL McGlynn, KA AF Purdue, Mark P. Graubard, Barry I. Chanock, Stephen J. Rubertone, Mark V. Erickson, Ralph L. McGlynn, Katherine A. TI Genetic variation in the inhibin pathway and risk of testicular germ cell tumors SO CANCER RESEARCH LA English DT Article ID FOLLICLE-STIMULATING-HORMONE; PREMATURE OVARIAN FAILURE; MUTATIONAL ANALYSIS; PROSTATE-CANCER; ALPHA-SUBUNIT; HUMAN GENOME; ASSOCIATION; POLYMORPHISMS; FOLLISTATIN; SUPPRESSOR AB Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors. It is not known whether genetic variation in the inhibin pathway also influences susceptibility to testicular germ cell tumors (TGCT), the most common testicular cancer in young men. To address this question, we conducted a case-control analysis (577 cases; 707 controls) of single-nucleotide polymorphisms (SNP) in genes in the inhibin pathway among participants in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study. Thirty-eight tagging SNPs in six genes (INHA, INHBA, INHBB, INHBC, INHBE, and SMAD4) were genotyped. Odds ratios (OR) and 95% confidence intervals (0) relating variant genotypes to TGCT risk were calculated using unconditional logistic regression. Among White subjects, an elevated risk of TGCT was observed for carriers of the T allele of the INHA variant rs2059693 (CT genotype: OR, 1.33; 95% CI, 1.04-1.71; TT: OR, 1.60; 95% CI, 1.01-2.52; P-trend = 0.008). The association with rs2059693 was stronger for nonseminomas, and for teratomas and teratocarcinomas in particular (N = 58; CT: OR, 1.63; 95% CI, 0.89-2.99; TT: OR, 4.54; 95% CI 2.00-10.3; P-trend = 0.0008). We found no evidence of association with variants in the other investigated genes. These findings suggest that genetic variation in the INHA locus influences TGCT development. C1 [Purdue, Mark P.; Graubard, Barry I.; McGlynn, Katherine A.] NCI, Div Canc Epiodemiol & Genet, Occupat & Environm Epidemiol Branch, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Chanock, Stephen J.] Natl Canc Inst Core Genotyping Facil, NIH, Dept Hlth & Human Dev, Gaithersburg, MD USA. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Washington, DC USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, Forest Glen, MD USA. RP Purdue, MP (reprint author), NCI, Div Canc Epiodemiol & Genet, Occupat & Environm Epidemiol Branch, NIH,Dept Hlth & Human Serv, EPS 8009,6120 Execut Blvd, Bethesda, MD 20892 USA. EM purduem@mail.nih.gov RI Purdue, Mark/C-9228-2016 OI Purdue, Mark/0000-0003-1177-3108 FU Intramural NIH HHS [Z01 CP010158-07] NR 36 TC 9 Z9 9 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2008 VL 68 IS 8 BP 3043 EP 3048 DI 10.1158/0008-5472.CAN-07-5852 PG 6 WC Oncology SC Oncology GA 290CM UT WOS:000255100500059 PM 18413775 ER PT J AU Olson, MA Feig, M Brooks, CL AF Olson, Mark A. Feig, Michael Brooks, Charles L., III TI Prediction of protein loop conformations using multiscale Modeling methods with physical energy scoring functions SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE energy landscapes; lattice simulations; molecular dynamics; replica exchange methods; generalized Born approximation ID EXPLICIT/IMPLICIT SOLVENT METHOD; MOLECULAR-DYNAMICS SIMULATIONS; STRUCTURALLY VARIABLE REGIONS; HIGH-RESOLUTION REFINEMENT; AB-INITIO CONSTRUCTION; GENERALIZED BORN MODEL; POLYPEPTIDE FRAGMENTS; HOMOLOGOUS PROTEINS; FORCE-FIELD; ALGORITHM AB This article examines ab initio methods for the prediction of protein loops by a computational strategy of multiscale conformational sampling and physical energy scoring functions. Our approach consists of initial sampling of loop conformations from lattice-based low-resolution models followed by refinement using all-atom simulations. To allow enhanced conformational sampling, the replica exchange method was implemented. Physical energy functions based on CHARMM19 and CHARMM22 parameterizations with generalized Born (GB) solvent models were applied in scoring loop conformations extracted from the lattice simulations and, in the case of all-atom simulations, the ensemble of conformations were generated and scored with these models. Predictions are reported for 25 loop segments, each eight residues long and taken from a diverse set of 22 protein structures. We find that the simulations generally sampled conformations with low global root-mean-square-deviation (RMSD) for loop backbone coordinates from the known structures, whereas clustering conformations in RMSD space and scoring detected less favorable loop structures. Specifically, the lattice simulations sampled basins that exhibited an average global RMSD of 2.21 +/- 1.42 angstrom, whereas clustering and scoring the loop conformations determined an RMSD of 3.72 +/- 1.91 angstrom. Using CHARMM19/GB to refine the lattice conformations improved the sampling RMSD to 1.57 +/- 0.98 angstrom and detection to 2.58 +/- 1.48 angstrom. We found that further improvement could be gained from extending the upper temperature in the all-atom refinement from 400 to 800 K, where the results typically yield a reduction of similar to 1 angstrom or greater in the RMSD of the detected loop. Overall, CHARMM19 with a simple pairwise GB solvent model is more efficient at sampling low-RMSD loop basins than CHARMM22 with a higher-resolution modified analytical GB model; however, the latter simulation method provides a more accurate description of the all-atom energy surface, yet demands a much greater computational cost. (c) 2007 Wiley Periodicals, Inc. C1 [Olson, Mark A.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. [Feig, Michael] Michigan State Univ, Dept Chem & Biochem, E Lansing, MI 48824 USA. [Brooks, Charles L., III] Scripps Res Inst, Dept Mol Biol TPC6, La Jolla, CA 92037 USA. [Brooks, Charles L., III] Scripps Res Inst, Ctr Theoret Biol Phys, La Jolla, CA 92037 USA. RP Olson, MA (reprint author), USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. EM molson@ncifcrf.gov NR 40 TC 24 Z9 24 U1 0 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0192-8651 J9 J COMPUT CHEM JI J. Comput. Chem. PD APR 15 PY 2008 VL 29 IS 5 BP 820 EP 831 DI 10.1002/jcc.20827 PG 12 WC Chemistry, Multidisciplinary SC Chemistry GA 275HU UT WOS:000254063300015 PM 17876760 ER PT J AU Shanmugam, S Ramisetti, NK Misra, RDK Hartmann, J Jansto, SG AF Shanmugam, S. Ramisetti, N. K. Misra, R. D. K. Hartmann, J. Jansto, S. G. TI Microstructure and high strength-toughness combination of a new 700 MPa Nb-microalloyed pipeline steel SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE pipeline steel; niobium-microalloyed; microstructure ID THERMOMECHANICAL CONTROL PROCESS; SERVICE LINE PIPE; MECHANICAL-PROPERTIES; LOW-CARBON; PRECIPITATION BEHAVIOR; TI; X70; MO; FORMABILITY; AUSTENITE AB A new ultrahigh strength niobium-microalloyed pipeline steel of yield strength similar to 700 MPa has been processed. The Charpy impact toughness at 0 degrees C was 27 J and tensile elongation was 16%. The ultrahigh strength is derived from the cumulative combination of fine grain size, solid solution strengthening with additional interstitial hardening, precipitation hardening from carbides, dislocation hardening, and mixed microstructure. The microstructure was characterized by polygonal ferrite, upper bainite, degenerated pearlite, and martensite-austenite (MA) constituents. The microstructure of weld and heat-affected zone (HAZ) was similar to the base metal such that the hardness is retained in the weld region implying insignificant softening in the weld zone. Niobium and titanium precipitates of different morphology and size range evolved during thermomechanical processing and include rectangular (similar to 500nm), irregular (similar to 240-500nm), cuboidal/spherical (similar to 125-300nm), and very fine (< 10nm). They were generally MC type of carbides. An important aspect of the developed steel is significantly lean chemistry. (c) 2007 Elsevier B.V. All rights reserved. C1 [Shanmugam, S.; Ramisetti, N. K.; Misra, R. D. K.] Univ SW Louisiana, Ctr Struct & Funct Mat, Lafayette, LA 70504 USA. [Shanmugam, S.; Ramisetti, N. K.; Misra, R. D. K.] Univ SW Louisiana, Dept Chem Engn, Lafayette, LA 70504 USA. [Hartmann, J.] USA, Ctr Res & Dev, E Chicago, IN 46312 USA. [Jansto, S. G.] Reference Met, Bridgeville, PA 15017 USA. RP Misra, RDK (reprint author), Univ SW Louisiana, Ctr Struct & Funct Mat, Lafayette, LA 70504 USA. EM dmisra@louisiana.edu RI shanmugam, sankaran/D-2355-2012 NR 37 TC 80 Z9 99 U1 11 U2 67 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD APR 15 PY 2008 VL 478 IS 1-2 BP 26 EP 37 DI 10.1016/j.msea.2007.06.003 PG 12 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 283OD UT WOS:000254644900004 ER PT J AU Taguenang, JM Kassu, A Ruffin, PB Brantley, C Edwards, E Sharma, A AF Taguenang, J. M. Kassu, A. Ruffin, P. B. Brantley, C. Edwards, E. Sharma, A. TI Reversible UV degradation of PMMA plastic optical fibers SO OPTICS COMMUNICATIONS LA English DT Article DE plastic optical fiber; UV degradation; Raman scattering ID POLY(METHYL METHACRYLATE); POLYMETHYLMETHACRYLATE AB Laser-induced fluorescence, Raman and absorption spectroscopy are used to investigate reversible degradation of transmission in PMMA optical fibers. When exposed to 254 nm UV light, optical transmission of PMMA plastic optical fiber in 400-800 nm range shows a significant increase in attenuation for shorter wavelengths. Over a period of 10 days following UV exposure, the transmittance of the plastic fiber recovers to a significant fraction of its pre-exposure value. UV-exposed fiber exhibits strong laser-induced fluorescence with 488 nm argon-ion laser. This fluorescence spans a spectral region between 450 nm and 750 nm with a peak around 580 nm. The fluorescence intensity decreases over several days following UV exposure. Likewise, Raman is also used to investigate degradation process. Freshly UV-exposed fiber shows total absence of Raman spectrum of PMMA. Following UV exposure, recovery of Raman signal over several days is correlated to the recovery of fiber transmittance as well as the decay of laser-induced fluorescence. A widely believed plausible explanation for UV-induced increase of attenuation involves formation of different macro radicals which recombine progressively after UV is stopped. Laser-induced fluorescence over several days is reported here providing direct evidence for molecular-level deterioration and recovery of PMMA. (C) 2007 Elsevier B.V. All rights reserved. C1 [Taguenang, J. M.; Kassu, A.; Sharma, A.] Alabama A&M Univ, Dept Phys, Normal, AL 35762 USA. [Ruffin, P. B.; Brantley, C.; Edwards, E.] USA, RDECOM, AMSRD AMR SG, Redstone Arsenal, AL 35898 USA. RP Sharma, A (reprint author), Alabama A&M Univ, Dept Phys, Meridian St, Normal, AL 35762 USA. EM anup.sharma@email.aamu.edu NR 14 TC 6 Z9 6 U1 1 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD APR 15 PY 2008 VL 281 IS 8 BP 2089 EP 2092 DI 10.1016/j.optcom.2007.12.031 PG 4 WC Optics SC Optics GA 282KH UT WOS:000254566000030 ER PT J AU Boddu, VM Abburi, K Randolph, AJ Smith, ED AF Boddu, Veera M. Abburi, Krishnaiah Randolph, Ann J. Smith, Edgar D. TI Removal of copper (II) and nickel (II) ions from aqueous solutions by a composite chitosan biosorbent SO SEPARATION SCIENCE AND TECHNOLOGY LA English DT Article DE adsorption; chitosan; copper (II); nickel (II); adsorption isotherms ID METAL-IONS; ADSORPTION PROPERTIES; EQUILIBRIUM; RESIN; COMPLEXATION; KINETICS; SORPTION; FLAKES; PEAT AB A composite chitosan biosorbent (CCB) was prepared by coating chitosan on to ceramic alumina. The adsorption characteristics of the sorbent for copper and nickel ions were studied under batch equilibrium and dynamic flow conditions at pH 4.0. The equilibrium adsorption data were correlated with Langmuir, Freundlich, and Redlich-Peterson models. The ultimate monolayer capacities, obtained from Langmuir isotherm, were 86.2 and 78.1mg/g of chitosan for Cu(II) and Ni(II), respectively. In addition, dynamic column adsorption studies were conducted to obtain breakthrough curves. After the column was saturated with metal ions, it was regenerated with 0.1M sodium hydroxide. The regenerated column was used for a second adsorption cycle. C1 [Boddu, Veera M.; Abburi, Krishnaiah; Randolph, Ann J.; Smith, Edgar D.] USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Environm Proc Branch, Champaign, IL 61826 USA. RP Boddu, VM (reprint author), USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Environm Proc Branch, Champaign, IL 61826 USA. EM veera.boddu@usace.army.mil NR 33 TC 33 Z9 34 U1 1 U2 21 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0149-6395 J9 SEPAR SCI TECHNOL JI Sep. Sci. Technol. PD APR 15 PY 2008 VL 43 IS 6 BP 1365 EP 1381 DI 10.1080/01496390801940762 PG 17 WC Chemistry, Multidisciplinary; Engineering, Chemical SC Chemistry; Engineering GA 286CF UT WOS:000254822300005 ER PT J AU Danylov, AA Waldman, J Goyette, TM Gatesman, AJ Giles, RH Li, J Goodhue, WD Linden, KJ Nixon, WE AF Danylov, Andriy A. Waldman, Jerry Goyette, Thomas M. Gatesman, Andrew J. Giles, Robert H. Li, Jin Goodhue, William D. Linden, Kurt J. Nixon, William E. TI Terahertz sideband-tuned quantum cascade laser radiation SO OPTICS EXPRESS LA English DT Article ID SPECTROSCOPY; FREQUENCY; WAVE; THZ; SPECTROMETER; POWER AB A compact, tunable, narrowband terahertz source was demonstrated by mixing a single longitudinal mode 2.408 THz, free running quantum cascade laser with a 2-20 GHz microwave sweeper in a conventional corner-cube-mounted Schottky diode. The sideband spectra were characterized with a Fourier transform spectrometer, and the radiation was tuned through several D2O rotational transitions to estimate the longer term (t >= several sec) bandwidth of the source. A spectral resolution of 2 MHz in CW regime was observed. (C) 2008 Optical Society of America. C1 [Danylov, Andriy A.; Waldman, Jerry; Goyette, Thomas M.; Gatesman, Andrew J.; Giles, Robert H.] Univ Massachusetts Lowell, Dept Phys & Appl Phys, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. [Li, Jin; Goodhue, William D.] Univ Massachusetts Lowell, Dept Phys & Appl Phys, Photon Ctr, Lowell, MA 01854 USA. [Linden, Kurt J.] Spire Corp, Bedford, MA 01730 USA. [Nixon, William E.] USA, Natl Ground Intelligence Ctr, Charlottesville, VA 22911 USA. RP Danylov, AA (reprint author), Univ Massachusetts Lowell, Dept Phys & Appl Phys, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. EM Andriy_Danylov@student.uml.edu NR 21 TC 12 Z9 12 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD APR 14 PY 2008 VL 16 IS 8 BP 5171 EP 5180 DI 10.1364/OE.16.005171 PG 10 WC Optics SC Optics GA 290JY UT WOS:000255120300002 PM 18542618 ER PT J AU Satya, RV Zavaljevski, N Kumar, K Reifman, J AF Satya, Ravi Vijaya Zavaljevski, Nela Kumar, Kamal Reifman, Jaques TI A high-throughput pipeline for designing microarray-based pathogen diagnostic assays SO BMC BIOINFORMATICS LA English DT Article ID SELECTING SIGNATURE OLIGONUCLEOTIDES; PROBE DESIGN; VIRUS IDENTIFICATION; CRITERIA; ALIGNMENT AB Background: We present a methodology for high-throughput design of oligonucleotide fingerprints for microarray-based pathogen diagnostic assays. The oligonucleotide fingerprints, or DNA microarray probes, are designed for identifying target organisms in environmental or clinical samples. The design process is implemented in a high-performance computing software pipeline that incorporates major algorithmic improvements over a previous version to both reduce computation time and improve specificity assessment. Results: The algorithmic improvements result in significant reduction in runtimes, with the updated pipeline being nearly up to five-times faster than the previous version. The improvements in specificity assessment, based on multiple specificity criteria, result in robust and consistent evaluation of cross-hybridization with nontarget sequences. In addition, the multiple criteria provide finer control on the number of resulting fingerprints, which helps in obtaining a larger number of fingerprints with high specificity. Simulation tests for Francisella tularensis and Yersinia pestis, using a well-established hybridization model to estimate cross-hybridization with nontarget sequences, show that the improved specificity criteria yield a larger number of fingerprints as compared to using a single specificity criterion. Conclusion: The faster runtimes, achieved as the result of algorithmic improvements, are critical for extending the pipeline to process multiple target genomes. The larger numbers of identified fingerprints, obtained by considering broader specificity criteria, are essential for designing probes for hard-to-distinguish target sequences. C1 [Satya, Ravi Vijaya; Zavaljevski, Nela; Kumar, Kamal; Reifman, Jaques] USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM rvijaya@bioanalysis.org; nelaz@bioanalysis.org; kamal@bioanalysis.org; jaques.reifman@us.army.mil OI Kumar, Kamal/0000-0002-9470-6682 NR 29 TC 11 Z9 11 U1 1 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD APR 10 PY 2008 VL 9 AR 185 DI 10.1186/1471-2105-9-185 PG 13 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 303JD UT WOS:000256035900001 ER PT J AU Opsenica, I Opsenica, D Smith, KS Milhous, WK Solaja, BA AF Opsenica, Igor Opsenica, Dejan Smith, Kirsten S. Milhous, Wilbur K. Solaja, Bogdan A. TI Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane Antimalarials SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID ANTIPROLIFERATIVE ACTIVITY; ACID-DERIVATIVES; 1,2,4,5-TETRAOXANES; ANTIMYCOBACTERIAL; DIHYDROPEROXIDES; ARTEMISININ; IODINE AB The development of widespread drug resistance to chloroquine (CQ(a)) has resulted in severe health issues for countries in malaria endemic regions. The antimalarial properties of artemisinin 2 and of other peroxides, such as 1,2,4,5-tetraoxacy-cloalkanes (tetraoxanes), have recently begun to be exploited in the development of new approaches to fighting CQ-resistant strains of malaria. New tetraoxanes employing a steroidal backbone have now been prepared that are highly active, are inexpensive, and demonstrate low toXieity.(5,6) A part of our research in this field is focused on the development of a new type of tetraoxane with nonidentical substituents(6) that utilize a steroid and small cyclohexylidene carriers possessing secondary amide bonds. Also, during our work in this field we discovered that tetraoxanes are unusually stable, even. at pH 1.6,(6c) a characteristic that subsequently allowed the synthesis of many interesting derivatives. This communication encompasses the synthesis of various amino-functionalized antimalarials based on the appreciable stability of the tetraoxane moiety to reaction conditions such as reductive amination and LiAlH4 reduction. Their respective antimalarial activities and the pronounced antiproliferative activity of certain products are reported along with in vitro metabolism studies. C1 [Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade, Serbia. [Opsenica, Igor; Opsenica, Dejan] Inst Chem Technol & Met, Belgrade, Serbia. [Smith, Kirsten S.; Milhous, Wilbur K.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Belgrade, Serbia. EM bsolaja@chem.bg.ac.yu RI Opsenica, Igor/P-5308-2016; OI Opsenica, Igor/0000-0003-4942-4042; Solaja, Bogdan/0000-0002-9975-2725 NR 23 TC 48 Z9 50 U1 0 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD APR 10 PY 2008 VL 51 IS 7 BP 2261 EP 2266 DI 10.1021/jm701417a PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 284LY UT WOS:000254709100031 PM 18330976 ER PT J AU Taylor, AJ Bindeman, J Feuerstein, I Le, T Bauer, K Byrd, C Wu, H O'Malley, PG AF Taylor, Allen J. Bindeman, Jody Feuerstein, Irwin Le, Toan Bauer, Kelly Byrd, Carole Wu, Holly O'Malley, Patrick G. TI Community-based provision of statin and aspirin after the detection of coronary artery calcium within a community-based screening cohort SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article ID BEAM COMPUTED-TOMOGRAPHY; HEART-DISEASE; RISK-FACTORS; INTERVENTION; PROJECT; UTILITY; EVENTS; TRIAL; PACC AB Objectives We examined the association of coronary artery calcium (CAC) detected on a screening exam with subsequent statin and aspirin usage in a healthy male screening cohort. Background Whether the presence of CAC, an independent predictor of coronary heart disease outcomes, alters clinical management, such as the use of preventive medications, is unknown. Methods Men (n = 1,640) ages 40 to 50 years (mean 42 years) were screened for coronary heart disease risk factors and CAC. The CAC scores and risk factors were reported to patients, and results were made available in the electronic medical record; however, medications were not prescribed or recommended by the study. During up to 6 years of subsequent annual structured telephone follow-up, we observed the community-based initiation and persistence of aspirin and statin therapy. Results A progressive increase in the incidence of pharmacotherapy was noted over time such that those with CAC were 3 times more likely to receive a statin (48.5% vs. 15.5%, p < 0.001) and also significantly more likely to receive aspirin (53.0% vs. 32.3%; p < 0.001) than those without CAC. In multivariable models controlling for National Cholesterol Education Program risk variables and baseline medication use, CAC was strongly and independently associated with use of either statin (odds ratio [OR] 3.53; 95% confidence interval [CI] 2.66 to 4.69), aspirin (OR 3.05; 95% CI 2.30 to 4.05) or both (OR 6.97; 95% CI 4.81 to 10.10). Conclusions In this prospective cohort, the presence of coronary calcification was associated with an independent 3-fold greater likelihood of statin and aspirin usage. C1 [Taylor, Allen J.; Bindeman, Jody; Feuerstein, Irwin; Le, Toan; Bauer, Kelly; Byrd, Carole; Wu, Holly; O'Malley, Patrick G.] Walter Reed Army Med Ctr, Serv Cardiol, Dept Med, Washington, DC 20307 USA. [Taylor, Allen J.; Feuerstein, Irwin; O'Malley, Patrick G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, Dept Med, 6900 Georgia Ave NW,Bldg 2,Room 4A34, Washington, DC 20307 USA. EM allen.taylor@na.amedd.army.mil NR 18 TC 59 Z9 60 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD APR 8 PY 2008 VL 51 IS 14 BP 1337 EP 1341 DI 10.1016/j.jacc.2007.11.069 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 284AL UT WOS:000254677500002 PM 18387433 ER PT J AU Alhamadsheh, MM Waters, NC Reynolds, K AF Alhamadsheh, Mamoun M. Waters, Norman C. Reynolds, Kevin TI MEDI 221-Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Alhamadsheh, Mamoun M.] Portland State Univ, Dept Chem, Portland, OR 97201 USA. [Waters, Norman C.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Reynolds, Kevin] Portland State Univ, Portland, OR 97207 USA. EM mamoun_alhamadsheh@hotmail.com; norman.waters@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 221-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775107110 ER PT J AU Artemenko, A Lyahovskij, AV Kuz'min, VE Muratov, EN Gorb, L Quasim, M Leszczynski, J AF Artemenko, Anatoly Lyahovskij, Anatoly V. Kuz'min, Victor E. Muratov, Eugene N. Gorb, Leonid Quasim, Mohammad Leszczynski, Jerzy TI COMP 127-Acute toxicity of polynitroaromatics and products of their biotransformation on Vibrio fischeri: 2-D QSAR- study SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Artemenko, Anatoly; Muratov, Eugene N.; Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Lyahovskij, Anatoly V.; Kuz'min, Victor E.] AV Bogatsky Phys Chem Inst NAS Ukraine, Lab Theoret Chem, UA-65080 Odessa, Ukraine. [Quasim, Mohammad] USA, Erdc, Vicksburg, MS 39180 USA. EM artanat@ukr.net; ldqsar@rambler.ru; victor@2good.org; murik@ccmsi.us; lgorb@ccmsi.us; jerzy@ccmsi.us RI Muratov, Eugene/C-4454-2014 OI Muratov, Eugene/0000-0003-4616-7036 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 127-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775104136 ER PT J AU Banks, HD AF Banks, Harold D. TI ORGN 201-A computational approach to increasing the reactivity of four-membered heterocycles SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Banks, Harold D.] USA, Res & Technol Directorate, Edgewood Chem Biol Ctr, AMSSB RRT TC Dr Harold D Banks, Aberdeen Proving Ground, MD 21010 USA. EM harold.banks@us.army.mil NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 201-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775107563 ER PT J AU Chen, CC Michael, M AF Chen Chiung-Chu Michael, McQuaid TI COMP 247-The determination of reaction rate constants for H-atom abstraction from N2H4 by H, NH2, CH3, C2H5 and NO2 SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Chen Chiung-Chu; Michael, McQuaid] USA, Res Lab, AMSRD ARL WM PB, Aberdeen Proving Ground, MD 21005 USA. EM chiungchu.chen@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 247-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775104209 ER PT J AU Dalavoy, TS Sweedler, JV Bohn, PW Lu, Y Shannon, MA Cropek, D AF Dalavoy, Tulika S. Sweedler, Jonathan V. Bohn, Paul W. Lu, Yi Shannon, Mark A. Cropek, Donald TI ENVR 157-Microfluidic/nanofluidic sensors using catalytic DNA for heavy metal detection SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Dalavoy, Tulika S.; Sweedler, Jonathan V.; Lu, Yi] Univ Illinois, Dept Chem, Urbana, IL 61801 USA. [Bohn, Paul W.] Univ Notre Dame, Dept Chem & Biomol Engn, Notre Dame, IN 46556 USA. [Shannon, Mark A.] Univ Illinois, Dept Engn Sci & Mech, Urbana, IL 61801 USA. [Cropek, Donald] USA CERL, Environm Proc Branch, Champaign, IL 61826 USA. EM tdalavoy@uiuc.edu; pbohn@nd.edu; yi-lu@uiuc.edu; mshannon@uiuc.edu; Donald.M.Cropek@erdc.usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 157-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775104483 ER PT J AU Douglas, T Walsh, ME Trainor, TP Jones, A McGrath, CJ Weiss, C AF Douglas, Thomas Walsh, Marianne E. Trainor, Thomas P. Jones, Ashley McGrath, Christian J. Weiss, Charles TI COLL 151-Breakdown of nitramine (RDX, HMX) and nitroaromatic (TNT) explosives on soil surfaces SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Douglas, Thomas] Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Walsh, Marianne E.] Cold Reg Res & Engn Lab, Geol Sci Div, Hanover, NH 03755 USA. [Trainor, Thomas P.; Jones, Ashley] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA. [McGrath, Christian J.] USA, Engn Res & Dev Ctr, CEWES ES Q, Waterways Expt Stn, Vicksburg, MS 39180 USA. EM Thomas.A.Douglas@erdc.usace.army.mil; marianne@crrel.usace.army.mil; fsamj@uaf.edu; mcgratc@mail.wes.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 151-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775103482 ER PT J AU Duncan, AJ Leo, DJ Long, TE Snyder, JF AF Duncan, Andrew J. Leo, Donald J. Long, Timothy E. Snyder, James F. TI POLY 427-Synthesis of long chain branched polysulfones for multifunctional transport membranes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA C1 [Duncan, Andrew J.] Virginia Tech, Macromol Sci & Engn Program, Blacksburg, VA 24060 USA. [Leo, Donald J.] Virginia Tech, Ctr Intelligent Mat, Dept Mech Engn, Blacksburg, VA 24061 USA. [Long, Timothy E.] Virginia Tech, Dept Chem, Blacksburg, VA 24060 USA. [Snyder, James F.] USA, Div Mat, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM ajduncan@vt.edu; donleo@vt.edu; telong@vt.edu; jsnyder@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 427-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519XJ UT WOS:000271802800611 ER PT J AU Duncan, AJ Sarles, SA Griffiths, D Leo, DJ Cashion, MP Layman, JM Long, TE Beyer, FL Colby, RH Fragiadakis, D Runt, J AF Duncan, Andrew J. Sarles, Stephen A. Griffiths, David Leo, Donald J. Cashion, Matthew P. Layman, John M. Long, Timothy E. Beyer, Frederick L. Colby, Ralph H. Fragiadakis, Daniel Runt, James TI POLY 695-Influence of topology and morphology in sulfonated polysulfone transducers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA C1 [Duncan, Andrew J.] Virginia Tech, Macromol Sci & Engn Program, Blacksburg, VA 24060 USA. [Sarles, Stephen A.; Griffiths, David; Leo, Donald J.] Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA. [Cashion, Matthew P.] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA. [Layman, John M.; Long, Timothy E.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Beyer, Frederick L.] USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. [Colby, Ralph H.; Fragiadakis, Daniel; Runt, James] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM ajduncan@vt.edu; sarles@vt.edu; dagriff2@vt.edu; donleo@vt.edu; mcashion@vt.edu; telong@vt.edu; flbeyer@arl.army.mil; rhc@plmsc.psu.edu; dmf24@psu.edu; runt@matse.psu.edu RI Sarles, Andy/J-6765-2012 NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 695-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519XJ UT WOS:000271802800604 ER PT J AU Fisher, RD DeLoia, MA AF Fisher, Raymond D. DeLoia, Matthew A. TI CHED 921-Structure and function of the Dd myosin VII Src homology 3 (SH3) domain SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Fisher, Raymond D.; DeLoia, Matthew A.] US Mil Acad, Dept Chem & Life Sci, Official Mail & Distribut Ctr MADN CHM LS, West Point, NY 10996 USA. EM Raymond.Fisher@usma.edu; mm8154@usma.edu NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 921-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775101515 ER PT J AU Fossey, SA AF Fossey, Stephen A. TI POLY 569-Applications of self-healing polymeric materials and processes in soldier systems SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA C1 [Fossey, Stephen A.] USA, Natick Soldier RD&E Ctr, Natick, MA 01760 USA. EM stephen.fossey@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 569-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519XJ UT WOS:000271802800495 ER PT J AU Hunley, MT Harber, A Orlicki, JA Rawlett, AM Long, TE AF Hunley, Matthew T. Harber, Adam Orlicki, Joshua A. Rawlett, Adam M. Long, Timothy E. TI PMSE 91-Electrospinning self-stratifying additives with poly(methyl methacrylate) SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Hunley, Matthew T.; Long, Timothy E.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Harber, Adam] Virginia Tech, Dept Chem Engn, Blacksburg, VA 24061 USA. [Orlicki, Joshua A.; Rawlett, Adam M.] USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. EM harber@vt.edu; orlicki@arl.army.mil; arawlett@arl.army.mil; telong@vt.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 91-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775109305 ER PT J AU Isayev, O Gorb, L Qasim, M Leszczynski, J AF Isayev, Olexandr Gorb, Leonid Qasim, Mo Leszczynski, Jerzy TI COMP 251-An ab initio molecular dynamics study of the initial chemical events in nitramines: Thermal decomposition of CL-20 SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Isayev, Olexandr; Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Qasim, Mo] US Army ERDC, Vicksburg, MS 39180 USA. EM alex@ccmsi.us; lgorb@ccmsi.us; jerzy@ccmsi.us NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 251-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775104174 ER PT J AU Kuz'min, V Muratov, EN Artemenko, AG Gorb, L Wang, J Quasim, M Leszczynski, J AF Kuz'min, Victor Muratov, Eugene N. Artemenko, Anatoly G. Gorb, Leonid Wang, Jing Quasim, Mohammad Leszczynski, Jerzy TI COMP 167-HiT QSAR analysis of chiral AchE inhibitors SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Kuz'min, Victor; Muratov, Eugene N.; Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Artemenko, Anatoly G.] NAS Ukraine, Lab Theoret Chem, AV Bogatsky Phys Chem Inst, UA-65080 Odessa, Ukraine. [Wang, Jing] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Quasim, Mohammad] USA, Erdc, Vicksburg, MS 39180 USA. EM victor@ccmsi.us; murik@ccmsi.us; lgorb@ccmsi.us; jerzy@ccmsi.us RI Muratov, Eugene/C-4454-2014 OI Muratov, Eugene/0000-0003-4616-7036 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 167-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775104134 ER PT J AU Major, JW Gutteridge, CE Bhattacharjee, AK AF Major, Joshua W. Gutteridge, Clare E. Bhattacharjee, Apurba K. TI CHED 1284-Antimalarial activity of aryl-substituted 2-ethoxyacetamides SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Major, Joshua W.; Gutteridge, Clare E.] USN Acad, Dept Chem, Annapolis, MD 21402 USA. [Bhattacharjee, Apurba K.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM gutterid@usna.edu; gutterid@usna.edu; apurba.bhattacharjee@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 1284-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775101678 ER PT J AU McPherson, JC Runner, R Pal, H Buxton, TB AF McPherson, James C., III Runner, Royce Pal Herczegh Buxton, Thomas B. TI MEDI 28-Acute osteomyelitis (OM): Nanometer-sized calcium phosphate (CP) particles as a carrier for bisphosphonate-ciprofloxacin (E41) antibiotic SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc, Div Cellulose & Renewble Mat C1 [McPherson, James C., III] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. [Runner, Royce; Buxton, Thomas B.] Geneva Fdn, Lakewood, WA 98405 USA. [Pal Herczegh] Univ Debrecen, Dept Pharmaceut Chem, H-4010 Debrecen, Hungary. EM james.mcpherson@amedd.army.mil; royce.runner@knology.net; herczeghp@gmail.com; tombuxton@aol.com NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 28-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775107069 ER PT J AU McReynolds, TE Skaggs, SA Schroeder, PA Herbert, JM AF McReynolds, Theresa E. Skaggs, Sheldon A. Schroeder, Paul A. Herbert, Joseph M. TI GEOC 31-Modeling the potter from the clay: Using chemical, mineralogical, and physical characteristics of clay materials to gain insights into prehistoric behavior SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [McReynolds, Theresa E.] Univ N Carolina, Res Labs Archaeol, Chapel Hill, NC 27599 USA. [Skaggs, Sheldon A.; Schroeder, Paul A.] Univ Georgia, Dept Geol, Athens, GA 30602 USA. [Herbert, Joseph M.] XVIII ABN Corps & Ft Bragg, Cultural Resources Program, Environm Sustainment Div, Ft Bragg, NC 28310 USA. EM temcre@email.unc.edu; skaggs1@uga.edu; schroe@uga.edu; joseph.herbert3@us.army.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 31-GEOC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775105046 ER PT J AU Milner, EE Cobar, JE AF Milner, Erin E. Cobar, Jose Eduardo TI MEDI 215-Lead optimization of next generation quinoline methanols SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Milner, Erin E.; Cobar, Jose Eduardo] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM erin.milner@us.army.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 215-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775107024 ER PT J AU Muratov, EN Kuz'min, VE Artemenko, AG Gorb, L Quasim, M Leszczynski, J AF Muratov, Eugene N. Kuz'min, Victor E. Artemenko, Anatoly G. Gorb, Leonid Quasim, Mohammad Leszczynski, Jerzy TI COMP 182-QSPR predictions of an aqueous solubility for military compounds using SiRMS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Muratov, Eugene N.; Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Kuz'min, Victor E.; Artemenko, Anatoly G.] AV Bogatsky Phys Chem Inst NAS Ukraine, Lab Theoret Chem, UA-65080 Odessa, Ukraine. [Quasim, Mohammad] USA, Erdc, Vicksburg, MS 39180 USA. EM murik@ccmsi.us; victor@2good.org; lgorb@ccmsi.us; jerzy@ccmsi.us RI Muratov, Eugene/C-4454-2014 OI Muratov, Eugene/0000-0003-4616-7036 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 182-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775104135 ER PT J AU Napadensky, E Sloan, JM AF Napadensky, Eugene Sloan, James M. TI PMSE 319-Thermogravimetric analysis of ion exchanged sulfonated poly(styrene-isobutylene-styrene) SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Napadensky, Eugene; Sloan, James M.] USA, Weap & Mat Res Directorate, Polymer Res Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM enapade@arl.army.mil; jsloan@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 319-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775109138 ER PT J AU Nguyen, CK Ingram, JM Richardson, LE Comitz, RL Stucky, GD AF Nguyen, Chi K. Ingram, John M. Richardson, Lance E. Comitz, Richard L. Stucky, Galen D. TI BIOL 42-Assembly of proteorhodopsin for the development of bioinspired energy devices SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Nguyen, Chi K.; Ingram, John M.; Richardson, Lance E.; Comitz, Richard L.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Stucky, Galen D.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. EM chi.nguyen@usma.edu; stucky@chem.ucsb.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 42-BIOL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775100688 ER PT J AU Orlicki, JA Rawlett, AM Zander, NE La Scala, JJ Kosik, WE Smith, P Andrews, K Demaree, JD AF Orlicki, Joshua A. Rawlett, Adam M. Zander, Nicole E. La Scala, John J. Kosik, W. E. Smith, Pauline Andrews, Kevin Demaree, J. D. TI POLY 321-Highly-branched multifunctional polymeric materials for Army applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA C1 [Orlicki, Joshua A.; Rawlett, Adam M.; Zander, Nicole E.; Kosik, W. E.] USA, Div Mat, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [La Scala, John J.; Smith, Pauline; Andrews, Kevin] USA, Div Mat, Mat Applicat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Demaree, J. D.] USA, Weap & Mat Res Directorate, AMSRD ARL WM MA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jorlicki@arl.army.mil; arawlett@arl.army.mil; nzander@arl.army.mil; jlascala@arl.army.mil; pmsmith@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 321-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519XJ UT WOS:000271802800457 ER PT J AU Orlicki, JA Wetzel, ED AF Orlicki, Joshua A. Wetzel, Eric D. TI POLY 570-Self-healing materials for Army applications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA C1 [Orlicki, Joshua A.] USA, Div Mat, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jorlicki@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 570-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519XJ UT WOS:000271802800462 ER PT J AU Robinette, EJ Bujanda, AA Jensen, RE McKnight, SH AF Robinette, E. Jason Bujanda, Andres A. Jensen, Robert E. McKnight, Steven H. TI PMSE 96-Temperature and rate dependence of adhesive bonding to glass substrates with controlled surface chemistry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Robinette, E. Jason; Bujanda, Andres A.; Jensen, Robert E.; McKnight, Steven H.] USA, Div Mat, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jason.robinette@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 96-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775109357 ER PT J AU Saito, T Mather, BD Beyer, FL Long, TE AF Saito, Tomonori Mather, Brian D. Beyer, Frederick L. Long, Timothy E. TI POLY 408-Does the location of sulfonated blocks matter? Influence of selective sulfonation in graft copolymer architecture SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA C1 [Saito, Tomonori; Mather, Brian D.; Long, Timothy E.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Beyer, Frederick L.] USA, Div Mat, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM tsaito@vt.edu; bmather@vt.edu; flbeyer@arl.army.mil; telong@vt.edu RI Saito, Tomonori/M-1735-2016 OI Saito, Tomonori/0000-0002-4536-7530 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 408-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519XJ UT WOS:000271802800684 ER PT J AU Sloop, JC Rhode, JR Washington, G Hoff, RH AF Sloop, Joseph C. Rhode, Jayne R. Washington, Gary Hoff, Richard H. TI CHED 530-Investigation of 1,2-sigmatropic rearrangements in N-phenylpyrazoles SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Sloop, Joseph C.; Rhode, Jayne R.; Washington, Gary; Hoff, Richard H.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. EM joseph.sloop@usma.edu; Jayne.Rhode@usma.edu; richard.Hoff@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 530-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775101516 ER PT J AU Suedel, BC AF Suedel, Burton C. TI ENVR 84-Chemical, toxicological and benthic community analysis of Violet Marsh sediments following Hurricane Katrina SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc C1 [Suedel, Burton C.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM burton.suedel@erdc.usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 84-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775104274 ER PT J AU Williams, DE Glaspell, GP Anderson, JE AF Williams, Dominique Ebony Glaspell, Garry P., II Anderson, John E. TI CHED 1191-Microwave synthesis of tunable, uniform rare earth oxide SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 235th American-Chemical-Society National Meeting CY APR 06-10, 2008 CL New Orleans, LA SP Amer Chem Soc, Div Cellulose & Renewble Mat C1 [Williams, Dominique Ebony] Amer Chem Soc, Dept Army Engineers, Richmond, VA 23220 USA. [Glaspell, Garry P., II] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA. [Anderson, John E.] USA, Erdc, Alexandria, VA 22315 USA. EM williamsde2@vcu.edu; gglaspell@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 6 PY 2008 VL 235 MA 1191-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 519OA UT WOS:000271775102376 ER PT J AU Blair, JRS Goddard, W Hedetniemi, ST Horton, S Jones, P Kubicki, G AF Blair, Jean R. S. Goddard, Wayne Hedetniemi, Stephen T. Horton, Steve Jones, Patrick Kubicki, Grzegorz TI On domination and reinforcement numbers in trees SO DISCRETE MATHEMATICS LA English DT Article DE domination; reinforcement; trees ID GRAPHS AB The reinforcement number of a graph is the smallest number of edges that have to be added to a graph to reduce the domination number. We introduce the k-reinforcement number of a graph as the smallest number of edges that have to be added to a graph to reduce the domination number by k. We present an O(k(2)n) dynamic programming algorithm for computing the maximum number of vertices that can be dominated using gamma(G) - k dominators for trees. A corollary of this is a linear-time algorithm for computing the k-reinforcement number of a tree. We also discuss extensions and related problems. (C) 2007 Elsevier B.V. All rights reserved. C1 [Blair, Jean R. S.; Horton, Steve] US Mil Acad, West Point, NY 10996 USA. [Goddard, Wayne; Hedetniemi, Stephen T.] Clemson Univ, Clemson, SC 29634 USA. [Jones, Patrick] Vanderbilt Univ, Nashville, TN 37240 USA. [Kubicki, Grzegorz] Univ Louisville, Louisville, KY 40292 USA. RP Blair, JRS (reprint author), US Mil Acad, West Point, NY 10996 USA. EM jean.blair@usma.edu; goddard@cs.clemson.edu; hedet@cs.cleiiison.edu; steve.horton@usma.edu; robomann@yahoo.com; gkubicki@louisville.edu NR 16 TC 10 Z9 10 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0012-365X J9 DISCRETE MATH JI Discret. Math. PD APR 6 PY 2008 VL 308 IS 7 BP 1165 EP 1175 DI 10.1016/j.disc.2007.03.067 PG 11 WC Mathematics SC Mathematics GA 261ZQ UT WOS:000253118900016 ER PT J AU Munger, S Cheung, KF AF Munger, Sophie Cheung, Kwok Fai TI Resonance in Hawaii waters from the 2006 Kuril Islands Tsunami SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article AB The 2006 Kuril Islands Tsunami, while not destructive to coastal properties, resulted in prolonged oscillations in Hawaii waters. This study examines the oscillation patterns and amplification through reconstruction of the tsunami using a nonlinear shallow-water model. After validation with water-level measurements, a Fast Fourier Transform of the computed surface elevation reveals profound oscillation modes at various periods around the Hawaiian Islands. The oscillation at the regional scale consists of standing waves across the island chain and resonance in interconnected channels, embayments, and shallow shelves. Resonance in embayments and standing edge waves dominate the oscillation in coastal waters. The results show strong correlation between bathymetric features and resonance oscillations and identify tsunami hazard areas for planning and emergency management. C1 [Cheung, Kwok Fai] Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA. RP Munger, S (reprint author), USA, Ctr Res Dev & Engn, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. EM sophie.munger@usace.army.mil; cheung@hawaii.edu NR 14 TC 33 Z9 33 U1 0 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD APR 5 PY 2008 VL 35 IS 7 AR L07605 DI 10.1029/2007GL032843 PG 7 WC Geosciences, Multidisciplinary SC Geology GA 284OX UT WOS:000254716800003 ER PT J AU Banks, HD AF Banks, Harold D. TI Dramatic effects of halogen substitution and solvent on the rates and mechanisms of nucleophilic substitution reactions of aziridines SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID SOLVATION MODELS; EPOXIDES; HETEROCYCLES; REACTIVITY AB In a previous study we reported that fluorine substitution at the carbon positions of aziridine results in profound enhancements of the rate of reaction with ammonia, a typical nucleophile, in the gas phase. In this study the investigation is extended to include chloro- and bromoaziridines. Because syntheses are largely performed in the condensed phase, the present computational investigation [(MP2(Full)/6-311++G-(d,p)//MP2(Full)/6-31+G(d) level] was conducted with three typical solvents that cover a wide range of polarity: THF, CH3CN, and H2O. Nucleophiles can react with haloaziridines I by displacing a substituted amide ion by means of an S(N)2 mechanism (pathway a), producing 1,2-diaminohaloethanes (from the initially formed dipolar species 2). Alternatively, a rearrangement mechanism involving rate-determining departure of a halide ion (pathway b) to form an imidoyl halide, 3, is possible. Transition-state theory was used to compute relative reaction rates of these mechanistic possibilities and to assess the role of the halogen substituents and the reaction solvent. Gas-phase results provided the basis of mechanistic insights that were more apparent in the absence of intermolecular interactions. Fluoroaziridines were found to react at accelerated rates relative to aziridine exclusively by means of the a Menshutkin-type mechanism (SN2) in each solvent tested, while the reactions of the chloro- and bromoaziridines could be directed toward 2 in the highly nonpolar solvent, cyclohexane, or toward 3 in the more polar solvents. An assessment is made of the feasibility of using this chemistry of the haloazirdines in the synthetic laboratory. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Banks, HD (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM harold.banks@us.army.mil NR 54 TC 10 Z9 10 U1 3 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD APR 4 PY 2008 VL 73 IS 7 BP 2510 EP 2517 DI 10.1021/jo7023224 PG 8 WC Chemistry, Organic SC Chemistry GA 282CI UT WOS:000254544800004 PM 18331051 ER PT J AU Brown, BG Taylor, AJ AF Brown, B. Greg Taylor, Allen J. TI Does ENHANCE diminish confidence in lowering LDL or in ezetimibe? SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material ID INTIMA-MEDIA THICKNESS; DOUBLE-BLIND TRIAL; FAMILIAL HYPERCHOLESTEROLEMIA; ATHEROSCLEROSIS PROGRESSION; PREVENTION; REGRESSION; TORCETRAPIB; THERAPY; PLAQUES; BIOLOGY C1 [Brown, B. Greg] Univ Washington, Sch Med, Seattle, WA 98195 USA. [Taylor, Allen J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Taylor, Allen J.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Brown, BG (reprint author), Univ Washington, Sch Med, Seattle, WA 98195 USA. FU NHLBI NIH HHS [HL-081616] NR 18 TC 60 Z9 61 U1 0 U2 2 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 3 PY 2008 VL 358 IS 14 BP 1504 EP 1507 DI 10.1056/NEJMe0801608 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 282CY UT WOS:000254546400015 PM 18376002 ER PT J AU Raghunath, A Perez-Branguli, F Smith, L Dolly, JO AF Raghunath, Arvind Perez-Branguli, Francesc Smith, Leonard Dolly, J. Oliver TI Adeno-associated virus transfer of a gene encoding SNAP-25 resistant to botulinum toxin a attenuates neuromuscular paralysis associated with botulism SO JOURNAL OF NEUROSCIENCE LA English DT Article DE botulinum; gene transfer; neuromuscular junction; motor neuron; SNARE proteins; sprouting ID SPINAL-CORD; CHROMAFFIN CELLS; NEUROTOXIN; EXOCYTOSIS; PERSISTENCE; INHIBITION; RESIDUES; CLEAVAGE; NEURONS; MOUSE AB Advances in viral gene therapy have opened new possibilities for treating a range of motor neuron diseases, but these have not yet been translated into clinically applicable therapies because of difficulties in delivery to susceptible/ damaged neurons, ambiguities in the identity of gene( s) implicated, and a paucity of means to quantify any physiological improvement. Most of these hurdles can be overcome by using the neuromuscular paralysis induced by botulinum neurotoxin type A ( BoNT/ A) as a prototype disease. Furthermore, because human botulism, occasionally fatal, causes prolonged muscle disablement as a result of the intraneuronal persistence of the toxin's SNAP- 25 ( S25)- cleaving protease, development of a genetic approach could lead to a potential treatment for this debilitating disease. Adeno- associated viral delivery of a cleavage- resistant S25 gene ( S25- R198T) to chromaffin cells in vitro yielded exocytotically active S25- R198T that diminished subsequent blockade by BoNT/ A of evoked catecholamine release. Evaluation in vivo, by administering this virus into rat spinal cord before injecting BoNT/ A, showed a decreased inhibition of acetylcholine release as reflected in elevated retention of neuromuscular transmission. A similar, although smaller, protection of synaptic transmission from the toxin was seen after peripherally injecting the therapeutic virus. Such therapy also curtailed nerve sprouting normally induced by BoNT/ A. This first demonstration of the utility of a DNA- based therapy for botulism paves the way for further advances in its treatment and for application to genetic disorders of motor neurons. C1 [Raghunath, Arvind; Perez-Branguli, Francesc; Dolly, J. Oliver] Dublin City Univ, Int Ctr Neurotherapeut, Dublin 9, Ireland. [Smith, Leonard] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Dolly, JO (reprint author), Dublin City Univ, Int Ctr Neurotherapeut, X230, Dublin 9, Ireland. EM oliver.dolly@dcu.ie RI Dolly, Oliver/G-1532-2012 OI Dolly, Oliver/0000-0002-0861-5320 NR 19 TC 7 Z9 7 U1 0 U2 3 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD APR 2 PY 2008 VL 28 IS 14 BP 3683 EP 3688 DI 10.1523/JNEUROSCI.5690-07.2008 PG 6 WC Neurosciences SC Neurosciences & Neurology GA 283GA UT WOS:000254623500017 PM 18385326 ER PT J AU Lloyd, B O'Connell, RJ Michael, NL Aviles, R Palou, E Hernandez, R Cooley, J Jagodzinski, LL AF Lloyd, Bradley O'Connell, Robert J. Michael, Nelson L. Aviles, Ricardo Palou, Elsa Hernandez, Rosalinda Cooley, John Jagodzinski, Linda L. TI Prevalence of resistance mutations in HIV-1-Infected Hondurans at the beginning of the national Antiretroviral therapy program SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID NEWLY INFECTED INDIVIDUALS; HIV-1 DRUG-RESISTANCE; RIO-DE-JANEIRO; NAIVE PATIENTS; GENOTYPIC RESISTANCE; BLOOD-DONORS; SURVEILLANCE; PERSISTENCE; SUBTYPES; STRAINS AB The Honduran Ministry of Health ( MOH) HIV antiretroviral treatment program began widespread treatment in 2003. We investigated the prevalence of antiretroviral genotypic resistance in specimens collected and archived from HIV-1-infected antiretroviral-naive patients presenting to initiate treatment between 1 July, 2002 and 30 June, 2003 in San Pedro Sula and Tegucigalpa, Honduras. Of 416 specimens collected, 336 ( 80.8%) were successfully genotyped. All genotypes were HIV-1, group M and 99.1% were subtype B. The prevalence of nucleoside reverse transcriptase inhibitor mutations was 7.7% with M184V and T215F/ Y present in 6.0% and 3.0%, respectively. The prevalence of nonnucleoside reverse transcriptase inhibitor mutations was 7.1%. K103N mutations were present in 3.0% of study specimens. The prevalence of major protease inhibitor mutations was 2.7%. Overall, 9.2% of the specimens harbored clinically significant mutations that predict at least intermediate resistance to the Honduran first-line antiretroviral medications. These mutations were more common in San Pedro Sula (14.0%) than in Tegucigalpa ( 6.5%, p = 0.02). A significant number of patients presenting to initiate antiretroviral therapy in Honduran MOH clinics harbored HIV-1 isolates resistant to the MOH's first- line regimen and resistance varied by region. Further studies to assess the impact of the Honduran antiretroviral program on genotypic resistance are warranted. C1 [Lloyd, Bradley] Wilford Hall USAF Med Ctr, Dept Infect Dis, Lackland AFB, TX 78236 USA. [O'Connell, Robert J.; Michael, Nelson L.; Jagodzinski, Linda L.] Walter Reed Army Med Ctr, Div Retrovirol, Rockville, MD 20850 USA. [Palou, Elsa] Inst Nacl Torax, Tegucigalpa, Honduras. [Cooley, John] Henry M Jackson Fdn, Rockville, MD 20850 USA. RP Lloyd, B (reprint author), Gastroenterol & Infect Dis Dept, 88th MDOS-SGOMB,4881 Sugar Maple Dr,WPAFB, Wright Patterson AFB, OH 45433 USA. EM bradley.lloyd@wpafb.af.mil NR 38 TC 17 Z9 19 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD APR PY 2008 VL 24 IS 4 BP 529 EP 535 DI 10.1089/aid.2007.0172 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 294GV UT WOS:000255394900001 PM 18366313 ER PT J AU Juompan, LY Hutchinson, K Montefiori, DC Nidtha, S Villinger, F Novembre, FJ AF Juompan, Laure Y. Hutchinson, Karen Montefiori, David C. Nidtha, Soumya Villinger, Francois Novembre, Francis J. TI Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; CD8(+) T-CELLS; LYMPHADENOPATHY-ASSOCIATED VIRUS; NEUTRALIZING ANTIBODIES; FUNCTIONAL PARAMETERS; CELLULAR-IMMUNITY; RHESUS-MONKEYS; SIV INFECTION; AIDS; LYMPHOCYTES AB The mechanisms of resistance to AIDS development in HIV-1-infected chimpanzees have remained elusive. Unique among chimpanzees naturally or experimentally infected with HIV, several animals of the Yerkes cohort have progressed to clinical AIDS with selection of isolates showing increased pathogenicity for chimpanzees. We compared progressors vs. nonprogressors among the HIV-infected chimpanzees that made up this cohort, eight of which have been infected with HIV-1 for over 14 years. The additional two progressors were infected de novo with chimpanzee-pathogenic HIV, rapidly leading to a progressor status. Nonprogressors were characterized by normal CD4(+) T cell counts and the absence of detectable viremia. In contrast, progressor chimpanzees had relatively high plasma viral loads associated with a dramatic loss of CD4(+) T cells. The analysis of immune responses showed a similar amplitude and breadth of ELISPOT T cell responses in both groups. HIV-specific proliferative responses were, however, absent in the progressor animals, which also exhibited increased levels of immune activation characterized by elevated levels of the circulating chemokines IP-10 and MCP-1. Of interest was the conservation of potent NK cell activity in all animals, potentially contributing to the extended symptom-free survival of progressor animals. Modest anti-HIV antibody titers were detectable in the nonprogressor group, but these antibodies exhibited good neutralizing activity. In progressors, however, two sets of data were noted: in animals that gradually selected for pathogenic isolates, or that were superinfected, very high neutralizing antibody titers were observed, although none to the pathogenic HIV. In contrast, two animals infected de novo with chimpanzee pathogenic HIV failed to mount an extensive humoral response and both failed to develop neutralizing antibodies to the virus. Taken together, pathogenic HIV infection in chimpanzees is associated with rapid loss of CD4(+) T cells and proliferative responses as well as higher levels of immune activation. C1 [Juompan, Laure Y.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Juompan, Laure Y.; Nidtha, Soumya; Novembre, Francis J.] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA. [Juompan, Laure Y.; Nidtha, Soumya; Novembre, Francis J.] Emory Univ, Dept Microbiol, Atlanta, GA 30329 USA. [Hutchinson, Karen] Ctr Dis Control, Special Pathogens Branch, Atlanta, GA 30333 USA. [Montefiori, David C.] Duke Univ, Med Ctr, Durham, NC 27706 USA. [Nidtha, Soumya] LLC, TransMed Partners, San Francisco, CA USA. [Villinger, Francois] Emory Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30329 USA. RP Juompan, LY (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, 503 Robert Grant Ave,Bldg 503,Room 3W63, Silver Spring, MD 20910 USA. EM laure.juompan@na.amedd.army.mil FU NCRR NIH HHS [RR000165, P51 RR000165]; NIAID NIH HHS [R01 AI-40879] NR 62 TC 15 Z9 15 U1 1 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD APR PY 2008 VL 24 IS 4 BP 573 EP 586 DI 10.1089/aid.2007.0182 PG 14 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 294GV UT WOS:000255394900007 PM 18426337 ER PT J AU Mitropoulos, P AF Mitropoulos, Panagiotis TI Infant with red, peeling rashes SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Mitropoulos, P (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. EM drmitropoulos@yahoo.com NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD APR 1 PY 2008 VL 77 IS 7 BP 1015 EP 1016 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 284AD UT WOS:000254676700019 PM 18441869 ER PT J AU Martin, EM Lu, WC Helmick, K French, L Warden, DL AF Martin, Elisabeth Moy Lu, Wei C. Helmick, Katherine French, Louis Warden, Deborah L. TI Traumatic brain injuries sustained in the Afghanistan and Iraq wars SO AMERICAN JOURNAL OF NURSING LA English DT Article ID REHABILITATION; CLIENTS AB Overview: When traumatic brain injury (TBI) occurs simultaneously with more obviously life-threatening wounds, it may go unrecognized. Civilians and military personnel working in or near combat zones are at risk for this injury. Blast-related and closed-head injuries, rather than penetrating injuries, constitute the majority of TBIs in this population. The authors describe the experiences of the Defense and Veterans Brain Injury Center team at Walter Reed Army Medical Center in Washington, DC, and present a composite case to illustrate the nurse's role in the assessment and care of the TBI patient. C1 [Martin, Elisabeth Moy; Lu, Wei C.; Helmick, Katherine; French, Louis; Warden, Deborah L.] Walter Reed Army Med Ctr, DVBIC, Washington, DC 20307 USA. RP Martin, EM (reprint author), Walter Reed Army Med Ctr, DVBIC, Washington, DC 20307 USA. EM lisamoymartin@yaboo.com NR 23 TC 41 Z9 42 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-936X J9 AM J NURS JI Am. J. Nurs. PD APR PY 2008 VL 108 IS 4 BP 40 EP 47 PG 8 WC Nursing SC Nursing GA 283SV UT WOS:000254657700016 PM 18367927 ER PT J AU Bottoni, CR Liddell, TR Trainor, TJ Freccero, DM Lindell, KK AF Bottoni, Craig R. Liddell, Travis R. Trainor, Timothy J. Freccero, David M. Lindell, Kenneth K. TI Postoperative range of motion following anterior cruciate ligament reconstruction using autograft hamstrings - A prospective, randomized clinical trial of early versus delayed reconstructions SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE ACL; timing; hamstring; acute ID MENISCAL REPAIR; PATELLAR TENDON; SURGERY; INJURIES; ARTHROFIBROSIS; REHABILITATION AB Background: There is a common belief that surgical reconstruction of an acutely torn anterior cruciate ligament (ACL) should be delayed for at least 3 weeks because of the increased incidence of postoperative motion loss (arthrofibrosis) and suboptimal clinical results. Hypothesis: There is no difference in postoperative range of motion or stability after ACL reconstructions performed either acutely or delayed. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Patients with an acute ACL tear were prospectively randomized to either early ( within 21days) or delayed ( beyond 6 weeks) reconstruction using autograft hamstring tendon. Previous knee surgery on the index extremity and a multiligamentous injury were exclusionary criteria. Surgical technique and postoperative rehabilitation were identical for all patients. Postoperative assessments included range of motion and KT-1000 arthrometer measurements compared with the contralateral knee. Standardized outcome measures were used including single assessment numeric evaluation (SANE), Lysholm, and Tegner Activity Score. Results: Seventy consecutive patients were enrolled, and 1 patient was dropped after a postoperative infection. Sixty-nine patients ( 34 acute, 35 delayed) with an average age of 27 years composed the study cohort. The mean time from injury to surgery was 9 days ( range, 2-17 days) for patients in the early group and 85 days (range, 42-192) for those in the delayed group. The average follow-up from surgery was 366 days ( range, 185-869). Articular cartilage and meniscal injuries were comparable between the 2 groups. There were no significant differences between the 2 treatment groups in degrees of extension or flexion lost relative to the nonoperative side, operative time, KT-1000 arthrometer differences, or subjective knee evaluations. Conclusion: Excellent clinical results can be achieved after ACL reconstructions performed soon after injury using autograft hamstrings. Although the authors do not advocate that all reconstructions should be performed acutely, they found that early ACL reconstructions do not result in loss of motion or suboptimal clinical results as long as a rehabilitation protocol emphasizing extension and early range of motion is employed. C1 [Bottoni, Craig R.] Qatar Orthopaed & Sports Med Ctr, Doha, Qatar. [Liddell, Travis R.; Trainor, Timothy J.; Freccero, David M.; Lindell, Kenneth K.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Bottoni, CR (reprint author), Qatar Orthopaed & Sports Med Ctr, POB 29222, Doha, Qatar. EM craig.bottoni@aspetar.com NR 25 TC 31 Z9 33 U1 0 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD APR PY 2008 VL 36 IS 4 BP 656 EP 662 DI 10.1177/0363546507312164 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 284BF UT WOS:000254679500004 PM 18212347 ER PT J AU de Roover, D Porter, LM Emami-Naeini, A Marohn, JA Kuehn, S Garner, S Smith, DD AF de Roover, Dick Porter, La Moyne, II Emami-Naeini, Abbas Marohn, John A. Kuehn, Seppe Garner, Sean Smith, Doran D. TI An all-digital cantilever controller for MRFM and scanned probe microscopy using a combined DSP/FPGA design SO AMERICAN LABORATORY LA English DT Article; Proceedings Paper CT Nanotech 2007 Conference CY MAY, 2007 CL Santa Clara, CA ID NUCLEAR-MAGNETIC-RESONANCE; DYNAMIC FORCE MICROSCOPY AB An all-digital cantilever controller for magnetic resonance force microscopy was developed through a close collaboration between SC Solutions, Cornell University, and the U.S. Army Research Laboratory. The advantage of an all-digital controller is its absence of thermal drift as well as its great tuning flexibility. The versatile controller comprises a field-programmable gate array connected via a low-latency interface to an analog input, an analog output, and a digital signal processor with additional analog outputs. Performance of the controller was demonstrated in experiments employing ultrasensitive silicon microcantilevers fabricated at Cornell University's Nanoscale Science and Technology Facility. C1 [de Roover, Dick; Porter, La Moyne, II; Emami-Naeini, Abbas] SC Solut, Sunnyvale, CA 94085 USA. [Marohn, John A.; Kuehn, Seppe; Garner, Sean] Cornell Univ, Ithaca, NY USA. [Smith, Doran D.] USA, Res Lab, Adelphi, MD USA. RP de Roover, D (reprint author), SC Solut, 1261 Oakmeal Pkwy, Sunnyvale, CA 94085 USA. EM roover@scsolutions.com NR 13 TC 0 Z9 0 U1 0 U2 8 PU INT SCIENTIFIC COMMUN INC PI SHELTON PA PO BOX 870, 30 CONTROLS DRIVE, SHELTON, CT 06484-0870 USA SN 0044-7749 J9 AM LAB JI Am. Lab. PD APR PY 2008 VL 40 IS 8 BP 12 EP + PG 6 WC Chemistry, Analytical; Instruments & Instrumentation SC Chemistry; Instruments & Instrumentation GA 298YX UT WOS:000255724100002 ER PT J AU McManus, JG Delgado, AV Kheiraback, BS AF McManus, J. G., Jr. Delgado, A., V Kheiraback, B. S. TI Preliminary screening of a new hemostatic product, Chitoflex (R), in a lethal arterial hemorrhage model in swine SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT 12th International Conference on Emergency Medicine CY APR 03-04, 2008 CL San Francisco, CA C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD APR PY 2008 VL 51 IS 4 MA 21 BP 477 EP 477 DI 10.1016/j.annemergmed.2008.01.289 PG 1 WC Emergency Medicine SC Emergency Medicine GA 283PG UT WOS:000254648000045 ER PT J AU Thomas, R McManus, JG Eastridge, B AF Thomas, R. McManus, J. G., Jr. Eastridge, B. TI Ocular injury reduction from ocular protection use in current combat operations SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT 12th International Conference on Emergency Medicine CY APR 03-04, 2008 CL San Francisco, CA C1 [Thomas, R.; McManus, J. G., Jr.; Eastridge, B.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD APR PY 2008 VL 51 IS 4 MA 184 BP 526 EP 526 DI 10.1016/j.annemergmed.2008.01.153 PG 1 WC Emergency Medicine SC Emergency Medicine GA 283PG UT WOS:000254648000206 ER PT J AU McManus, JG McClinton, A Eastridge, B AF McManus, J. G., Jr. McClinton, A. Eastridge, B. TI Ethical conduction of research in the tactical, austere setting SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT 12th International Conference on Emergency Medicine CY APR 03-04, 2008 CL San Francisco, CA C1 Brooke Army Med Ctr, Ft Sam Houston, TX USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD APR PY 2008 VL 51 IS 4 MA 271 BP 553 EP 553 DI 10.1016/j.annemergmed.2008.01.242 PG 1 WC Emergency Medicine SC Emergency Medicine GA 283PG UT WOS:000254648000293 ER PT J AU Becker, TE Ellsworth, RE Deyarmin, B Patney, HL Jordan, RM Hooke, JA Shriver, CD Ellsworth, DL AF Becker, Tyson E. Ellsworth, Rachel E. Deyarmin, Brenda Patney, Heather L. Jordan, Rick M. Hooke, Jeffrey A. Shriver, Craig D. Ellsworth, Darrell L. TI The genomic heritage of lymph node metastases: Implications for clinical management of patients with breast cancer SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article; Proceedings Paper CT 5th International Meeting on Hepatocellular Carcinoma CY JAN 11-13, 2007 CL Houston, TX DE metastasis; breast cancer; allelic imbalance; axillary lymph nodes ID TUMOR DORMANCY; CELLS; PROGRESSION; EVOLUTION; THERAPY; MICROMETASTASES; ANGIOGENESIS; CHEMOTHERAPY; RADIOTHERAPY; CARCINOMAS AB Background: Metastatic breast cancer is an aggressive disease associated with recurrence and decreased survival. To improve outcomes and develop more effective treatment strategies for patients with breast cancer, it is important to understand the molecular mechanisms underlying metastasis. Methods: We used allelic imbalance (AI) to determine the molecular heritage of primary breast tumors and corresponding metastases to the axillary lymph nodes. Paraffin-embedded samples from primary breast tumors and matched metastases (n = 146) were collected from 26 patients with node-positive breast cancer involving multiple axillary nodes. Hierarchical clustering was used to assess overall differences in the patterns of AI, and phylogenetic analysis inferred the molecular heritage of axillary lymph node metastases. Results: Overall frequencies of AI were significantly higher (P < 0.01) in primary breast tumors (23%) than in lymph node metastases (15%), and there was a high degree of discordance in patterns of AI between primary breast carcinomas and the metastases. Metastatic tumors in the axillary nodes showed different patterns of chromosomal changes, suggesting that multiple molecular mechanisms may govern the process of metastasis in individual patients. Some metastases progressed with few genomic alterations, while others harbored many chromosomal alterations present in the primary tumor. Conclusions: The extent of genomic heterogeneity in axillary lymph node metastases differs markedly among individual patients. Genomic diversity may be associated with response to adjuvant therapy, recurrence, and survival, and thus may be important in improving clinical management of breast cancer patients. C1 [Becker, Tyson E.; Ellsworth, Rachel E.; Deyarmin, Brenda; Patney, Heather L.; Jordan, Rick M.; Ellsworth, Darrell L.] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. [Ellsworth, Rachel E.] Henry M Jackson Fdn, Adv Mil Med, Rockville, MD 20852 USA. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. RP Ellsworth, DL (reprint author), Windber Res Inst, Clin Breast Care Project, 620 7 St, Windber, PA 15963 USA. EM d.ellsworth@wriwindber.org NR 39 TC 14 Z9 17 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD APR PY 2008 VL 15 IS 4 BP 1056 EP 1063 DI 10.1245/s10434-008-9815-3 PG 8 WC Oncology; Surgery SC Oncology; Surgery GA 272XW UT WOS:000253896000016 PM 18246400 ER PT J AU Polhemus, ME Remich, S Ogutu, B Waitumbi, J Lievens, M Ballou, WR Heppner, DG AF Polhemus, Mark E. Remich, Shon Ogutu, Bernhards Waitumbi, John Lievens, Marc Ballou, W. Ripley Heppner, D. Gray, Jr. TI Malaria treatment with atovaquone-proguanil in malaria-immune adults: Implications for malaria intervention trials and for pre-exposure prophylaxis of malaria SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM-FALCIPARUM; CHEMOPROPHYLAXIS; CHILDREN; KENYA; AREA AB Eighty adults in areas of Kenya where malaria is holoendemic received presumptive treatment with atovaquone-proguanil and were followed closely. The time to the first Plasmodium falciparum parasitemia was 32 days. This prolonged prophylaxis period has implications for study design when used in malaria intervention trials and cautiously suggests clinical investigation of potential preexposure prophylaxis of malaria. C1 [Polhemus, Mark E.; Remich, Shon] USA, Resp Med Unit, Walter Reed Project, Kisumu, Kenya. [Ogutu, Bernhards; Waitumbi, John] Kenya Govt Med Res Ctr, Clin Res Ctr, Kisumu, Kenya. [Lievens, Marc; Ballou, W. Ripley] GlaxoSmithKline Biol, Rixensart, Belgium. [Heppner, D. Gray, Jr.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Polhemus, ME (reprint author), Unit 64109 MRU, APO, AE 09831 USA. EM mpolhemus@wrp-ksm.org NR 11 TC 4 Z9 4 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 2008 VL 52 IS 4 BP 1493 EP 1495 DI 10.1128/AAC.01367-07 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 286YE UT WOS:000254881900039 PM 18268090 ER PT J AU Spurgers, KB Sharkey, CM Warfield, KL Bavari, S AF Spurgers, Kevin B. Sharkey, C. Matthew Warfield, Kelly L. Bavari, Sina TI Oligonucleotide antiviral therapeutics: Antisense and RNA interference for highly pathogenic RNA viruses SO ANTIVIRAL RESEARCH LA English DT Article DE RNA virus; RNA interference; antisense; siRNA; phosphorodiamidate morpholino oligomer ID ACUTE RESPIRATORY SYNDROME; INFLUENZA-A VIRUS; WEST-NILE-VIRUS; NUCLEOPROTEIN GENES EXPRESSION; VENEZUELAN EQUINE ENCEPHALITIS; MORPHOLINO OLIGOMER CONJUGATE; SARS-CORONAVIRUS; IN-VIVO; PROTEIN EXPRESSION; CELL-CULTURES AB RNA viruses are a significant source of morbidity and mortality in humans every year. Additionally, the potential use of these viruses in acts of bioterrorism poses a threat to national security. Given the paucity of vaccines or postexposure therapeutics for many highly pathogenic RNA viruses, novel treatments are badly needed. Sequence-based drug design, under development for almost 20 years, is proving effective in animal models and has moved into clinical trials. Important advances in the field include the characterization of RNA interference in mammalian cells and chemical modifications that can dramatically increase the in vivo stability of therapeutic oligonucleotides. Antisense strategies utilize single-stranded DNA oligonucleoticles that inhibit protein production by mediating the catalytic degradation of target mRNA, or by binding to sites on mRNA essential for translation. Double-stranded RNA oligonucleotides, known as short- interfering RNAs (siRNAs), also mediate the catalytic degradation of complementary mRNAs. As RNA virus infection is predicated on the delivery, replication, and translation of viral RNA, these pathogens present an obvious target for the rapidly advancing field of sequence-specific therapeutics. Antisense oligonucleotides or siRNAs can be designed to target the viral RNA genome or viral transcripts. This article reviews current knowledge on therapeutic applications of antisense and RNA interference for highly pathogenic RNA viral infections. (C) 2008 Elsevier B.V, All rights reserved. C1 [Spurgers, Kevin B.; Sharkey, C. Matthew; Warfield, Kelly L.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM kevin.spurgers@us.ar-my.mit; sharkey@battelle.org; kelly.warfield@us.army.mil; sina.bavari@us.army.mil NR 92 TC 53 Z9 57 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD APR PY 2008 VL 78 IS 1 BP 26 EP 36 DI 10.1016/j.antiviral.2007.12.008 PG 11 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 290ZY UT WOS:000255163300003 PM 18258313 ER PT J AU Khan, SH Goba, A Chu, M Roth, C Healing, T Marx, A Fair, J Guttieri, MC Ferro, P Imes, T Monagin, C Garry, RF Bausch, DG AF Khan, Sheik Humarr Goba, Augustine Chu, May Roth, Cathy Healing, Tim Marx, Arthur Fair, Joseph Guttieri, Mary C. Ferro, Philip Imes, Tiffany Monagin, Corina Garry, Robert F. Bausch, Daniel G. TI New opportunities for field research on the pathogenesis and treatment of Lassa fever SO ANTIVIRAL RESEARCH LA English DT Review DE Lassa virus; Lassa fever; Arenavirus; viral hemorrhagic fever; West Africa; antiviral therapy; ribavirin; pathogenesis ID PICHINDE VIRUS-INFECTION; VIRAL HEMORRHAGIC FEVERS; LINKED-IMMUNOSORBENT-ASSAY; PLATELET-ACTIVATING-FACTOR; MARCH-APRIL 1972; GUINEA-PIGS; SEVERE SEPSIS; SIERRA-LEONE; WEST-AFRICA; EPIDEMIOLOGICAL ASPECTS AB Unlike many viral hemorrhagic fevers (VHFs), Lassa fever (LF) is not a rare disease that emerges only as sporadic cases or in outbreak form. Although surveillance is inadequate to determine the true incidence, up to 300,000 infections and 5000 deaths from LF are estimated to occur yearly. The highest incidence is in the "Mano River Union (MRU) countries" of Sierra Leone, Liberia, and Guinea. Although civil unrest in this region over the past two decades has impeded capacity building and research, new-found peace in recent years presents new opportunities. In 2004, the Mano River Union Lassa Fever Network (MRU LFN) was established to assist NIRU countries in the development of national and regional surveillance, diagnosis, treatment, control, and prevention of LF. Here, we review the present literature on treatment and pathogenesis of LF and outline priorities for future research in the field made possible by the improved research capacity of the MRU LFN. (C) 2007 Elsevier B.V. All rights reserved. C1 [Khan, Sheik Humarr; Goba, Augustine; Fair, Joseph; Imes, Tiffany; Monagin, Corina; Garry, Robert F.; Bausch, Daniel G.] Tulane Univ, Hlth Sci Ctr, Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA 70112 USA. [Khan, Sheik Humarr; Goba, Augustine] Kenema Govt Hosp, Minist Hlth & Sanitat, Kenema, Sierra Leone. [Chu, May; Roth, Cathy; Healing, Tim; Marx, Arthur] WHO, CH-1211 Geneva, Switzerland. [Fair, Joseph; Guttieri, Mary C.; Ferro, Philip] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bausch, DG (reprint author), Tulane Univ, Hlth Sci Ctr, Sch Publ Hlth & Trop Med, Dept Trop Med, SL-17,1430 Tulane Ave, New Orleans, LA 70112 USA. EM dbausch@tulane.edu NR 115 TC 80 Z9 81 U1 4 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD APR PY 2008 VL 78 IS 1 BP 103 EP 115 DI 10.1016/j.antiviral.2007.11.003 PG 13 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 290ZY UT WOS:000255163300012 PM 18241935 ER PT J AU Jonsson, CB Hooper, J Mertz, G AF Jonsson, Colleen B. Hooper, Jay Mertz, Gregory TI Treatment of hantavirus pulmonary syndrome SO ANTIVIRAL RESEARCH LA English DT Article DE hantavirus; HPS; HFRS; hantavirus pulmonary syndrome; bunyavirus; antiviral therapy; ribavirin ID TO-PERSON TRANSMISSION; SIN-NOMBRE-VIRUS; NEUTRALIZING ANTIBODY-RESPONSE; MOUSE PEROMYSCUS-MANICULATUS; KOREAN HEMORRHAGIC-FEVER; HANTAAN-VIRUS; RENAL SYNDROME; CARDIOPULMONARY SYNDROME; NUCLEOCAPSID PROTEIN; ANDES VIRUS AB Viruses in the genus Hantavirus can cause one of two serious illnesses when transmitted from rodents to humans: hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Of the two diseases, HPS is more severe with an approximate 40% mortality across the Americas. The high rate of mortality could be reduced if effective therapeutics could be discovered for treatment of this illness. Herein we review approaches being explored for the discovery of therapeutics for HPS and how they could be employed in treatment and preventiom of disease. (C) 2007 Elsevier B.V. All rights reserved. C1 [Jonsson, Colleen B.] So Res Inst, Dept Biochem & Mol Biol, Birmingham, AL 35205 USA. [Hooper, Jay] USA, Med Res Inst Infect Dis, Mol Virol Branch, Ft Detrick, MD 21702 USA. [Mertz, Gregory] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA. RP Jonsson, CB (reprint author), So Res Inst, Dept Biochem & Mol Biol, 2000 9th Ave S, Birmingham, AL 35205 USA. EM Jonsson@sri.org OI Hooper, Jay/0000-0002-4475-0415 FU NIAID NIH HHS [R21 AI064499, R21 AI064499-01, R21 AI064499-02] NR 94 TC 60 Z9 63 U1 2 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD APR PY 2008 VL 78 IS 1 BP 162 EP 169 DI 10.1016/j.antiviral.2007.10.012 PG 8 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 290ZY UT WOS:000255163300018 PM 18093668 ER PT J AU Walters, TJ Kragh, JF Baer, DG AF Walters, Thomas J. Kragh, John F. Baer, David G. TI Influence of fiber-type composition on recovery from tourniquet-induced skeletal muscle ischemia-reperfusion injury SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME LA English DT Article DE atrophy; contractile properties; edema; rats; regeneration ID RAT STRIATED-MUSCLE; PNEUMATIC TOURNIQUET; CONTRACTILE PROPERTIES; ELECTRICAL-STIMULATION; EARLY MOBILIZATION; INDUCED BENEATH; CRUSH INJURY; SLOW; HYPOTHERMIA; ISOFORM AB This study was designed to determine if previously reported differences in the functional impairment of muscles composed of predominantly different fiber types occurs following extended periods of ischemia. We hypothesized that the soleus (Sol) muscle, a predominantly slow-twitch muscle, would be less vulnerable to tourniquet-induced ischemia-reperfusion than the plantaris (Plant), a predominantly fast-twitch muscle, as determined by the assessment of isometric contractile function. Male Sprague-Dawley rats were assigned to one of the following groups to undergo tourniquet application (TKA) (n = 6/group): 2 h TKA, 2 d recovery; 4 h TKA, 2 d recovery; 2 h TKA, 14 d recovery; or 4 h TKA, 14 d recovery. In situ isometric contractile properties were assessed in the predominantly slow-twitch Sol and the predominantly fast-twitch Plant; the contralateral muscle served as the internal control. At 2 d, muscle contraction could not be elicited via neural stimulation, but muscles did contract with direct stimulation, which indicates neural injury. This condition was resolved by day 14. At this time point, tetanic tension (Po) in the Plant was reduced by 45% and 69% in the 2 and 4 h groups, respectively. Po for the Sol was unaffected in the 2 h group, but was reduced by 30% in the 4 h group. The fatigue resistance of the Plant was increased 2 fold in the 4 h group and was unchanged in all other groups. These results demonstrate that vulnerability to tourniquet-induced ischemia-reperfusion injury is dramatically different with respect to muscle fiber-type composition. C1 [Walters, Thomas J.; Kragh, John F.; Baer, David G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Walters, TJ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM thomas.walters@amedd.army.mil NR 51 TC 18 Z9 19 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS PI OTTAWA PA BUILDING M 55, OTTAWA, ON K1A 0R6, CANADA SN 1715-5312 J9 APPL PHYSIOL NUTR ME JI Appl. Physiol. Nutr. Metab. PD APR PY 2008 VL 33 IS 2 BP 272 EP 281 DI 10.1139/H07-180 PG 10 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA 318OF UT WOS:000257100700006 PM 18347682 ER PT J AU Gottfried, JL De Lucia, FC Munson, CA Miziolek, AW AF Gottfried, Jennifer L. De Lucia, Frank C., Jr. Munson, Chase A. Miziolek, Andrzej W. TI Standoff detection of chemical and biological threats using laser-induced breakdown spectroscopy SO APPLIED SPECTROSCOPY LA English DT Article DE laser-induced breakdown spectroscopy; LIBS; standoff detection; biological warfare agents; chemical warfare agents; linear correlation; partial least squares; discriminant analysis; PLS-DA ID WARFARE AGENT SIMULANTS; INDUCED FLUORESCENCE; IDENTIFICATION; BIOAEROSOLS; TECHNOLOGY; DISCRIMINATION; CLASSIFICATION; BACTERIA; POLLEN; SPORES AB Laser-induced breakdown spectroscopy (LIBS) is a promising technique for real-time chemical and biological warfare agent detection in the field. We have demonstrated the detection and discrimination of the biological warfare agent surrogates Bacillus subtilis (BG) (2% false negatives, 0% false positives) and ovalbumin (0% false negatives, 1% false positives) at 20 meters using standoff laser-induced breakdown spectroscopy (ST-LIBS) and linear correlation. Unknown interferent samples (not included in the model), samples on different substrates, and mixtures of BG and Arizona road dust have been classified with reasonable success using partial least squares discriminant analysis (PLS-DA). A few of the samples tested such as the soot (not included in the model) and the 25% BG:75% dust mixture resulted in a significant number of false positives or false negatives, respectively. Our preliminary results indicate that while LIBS is able to discriminate biomaterials with similar elemental compositions at standoff distances based on differences in key intensity ratios, further work is needed to reduce the number of false positives/negatives by refining the PLS-DA model to include a sufficient range of material classes and carefully selecting a detection threshold. In addition, we have demonstrated that LIBS can distinguish five different organophosphate nerve agent simulants at 20 meters, despite their similar stoichiometric formulas. Finally, a combined PLS-DA model for chemical, biological, and explosives detection using a single ST-LIBS sensor has been developed in order to demonstrate the potential of standoff LIBS for universal hazardous materials detection. C1 [Gottfried, Jennifer L.; De Lucia, Frank C., Jr.; Munson, Chase A.; Miziolek, Andrzej W.] USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. RP Gottfried, JL (reprint author), USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.gottfried@arl.army.mil RI Gottfried, Jennifer/G-6333-2010; Munson, Chase/H-1667-2012; De Lucia, Frank/D-5630-2012 NR 41 TC 84 Z9 86 U1 4 U2 39 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 201B BROADWAY ST, FREDERICK, MD 21701 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD APR PY 2008 VL 62 IS 4 BP 353 EP 363 DI 10.1366/000370208784046759 PG 11 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 285VD UT WOS:000254803400002 PM 18416891 ER PT J AU Paparone, CR Anderson, RA McDaniel, RR AF Paparone, Christopher R. Anderson, Ruth A. McDaniel, Reuben R., Jr. TI Where military professionalism meets complexity science SO ARMED FORCES & SOCIETY LA English DT Article DE leadership; professionals; complex adaptive systems; mental models; hierarchical design ID ORGANIZATIONS; DEMOCRACY; KNOWLEDGE; QUANTUM; CHAOS; VIEW AB The authors challenge the old school of hierarchical strategic leadership that dominates the military professional culture and, in contrast, emphasize complex adaptive systems (CASs) as a compelling alternative mental model to view the military profession. The authors suggest eight leadership tasks that come to the fore when the mental model of the military as a professional CAS is used to examine the circumstances that engulf military activities: relationship building, loose coupling, complicating, diversifying, sensemaking, learning, improvising, and emergent thinking. These are distinguished from the traditional tasks of role defining, standardization, simplifying, socializing, decision making, knowing, commanding and controlling, and planning based on estimates. C1 [Paparone, Christopher R.] US Army Command & Gen Staff Coll, Dept Logist & Resource Operat, Ft Lee, VA USA. [Anderson, Ruth A.] Duke Univ, Sch Nursing, Durham, NC 27706 USA. [McDaniel, Reuben R., Jr.] Univ Texas Austin, McCombs Sch Business, Austin, TX USA. RP Paparone, CR (reprint author), US Army Command & Gen Staff Coll, Dept Logist & Resource Operat, Ft Lee, VA USA. OI Anderson, Ruth/0000-0001-6640-644X NR 41 TC 2 Z9 2 U1 0 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD APR PY 2008 VL 34 IS 3 BP 433 EP 449 DI 10.1177/0095327X07310337 PG 17 WC Political Science; Sociology SC Government & Law; Sociology GA 275HN UT WOS:000254062600004 ER PT J AU Moten, M AF Moten, Matthew TI "The Stuff of tragedy" - Shinseki's reply to Levin SO ARMED FORCES & SOCIETY LA English DT Article DE civilian control; civil-military relations; Levin; Shinseki; Rumsfeld AB Damon Coletta's "Courage in the Service of Virtue" accuses General Eric K. Shinseki of publicly challenging administration policy in a way that "improvised in areas such as war-fighting and diplomacy beyond his official purview," contradicted the combatant commander, aided the French, abetted the Democrats, emboldened Saddam, and damaged American civil-military relations because it dismissed the policy makers' "right to be wrong." Shinseki did none of these things, including publicly challenging administration policy. This article will provide some historical corrective and context for this debate. It will examine Shinseki's options and argue that, rather than damaging civilian control, Shinseki protected it through acts of commission and omission, through forthrightness and restraint toward both sets of his civilian masters enumerated in the Constitution to control the military, the executive and legislative branches of government. C1 US Mil Acad, West Point, NY 10996 USA. RP Moten, M (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 23 TC 0 Z9 0 U1 1 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD APR PY 2008 VL 34 IS 3 BP 509 EP 516 DI 10.1177/0095327X07308619 PG 8 WC Political Science; Sociology SC Government & Law; Sociology GA 275HN UT WOS:000254062600009 ER PT J AU Putaporntip, C Seethamchai, S Suvannadhat, V Hongsrimuanga, T Sattabongkot, J Jongwutiwes, S AF Putaporntip, Chaturong Seethamchai, Sunee Suvannadhat, Vit Hongsrimuanga, Thongchai Sattabongkot, Jetsumon Jongwutiwes, Somchai TI Selective pressure on the merozoite surface protein-1 genes of Plasmodium vivax, P-knowlesi and P-cynomolgi SO ASIAN BIOMEDICINE LA English DT Article DE malaria; merozoite surface protein 1; natural selection; Plasmodium vivax; Plasmodium knowlesi; Plasmodium cynomolgi; selective pressure ID HUMAN MALARIA PARASITE; ERYTHROCYTE INVASION; FALCIPARUM MALARIA; CELL INVASION; MONKEYS; ANTIGEN; RECOMBINATION; ANTIBODIES; EVOLUTION; CONSERVATION AB Background. The merozoite surface protein 1 (msp-1) of malarial parasites is a promising target for malaria vaccine development. Because antigenic polyrnorphism of this protein occurs in both Plasmodium falciparum and R vivax, it is important to know the extent of sequence variation of this gene in nonhuman primate malarias that can infect humans. Objective: To determine the complete nucleotide sequences of the msp-1 genes of Plasmodium knowlesi (Pkmsp-1) and P cynomolgi (Pcymsp-1) and their evolutionary history comparing with an orthologous gene of P vivax (Pvmsp-1). Method. The msp-1 genes of R knowlesi and P cynomolgi were amplified by the polymerase chain reaction and their nucleotide sequences were determined directly from the amplified products. Sequences were aligned using the Clustal X program. The extent of polymorphism is expressed in terms of nucleotide diversity (pi) and the average number of nucleotide substitutions per site between populations (Dxy) in pair-wise comparison. The ratio of nucleotide substitutions at synonymous and nonsynonymous sites was computed by the McDonald and Kreitman test to detect evidence of departure from neutrality. The phylogenetic tree was constructed by the neighbor-joining method using the maximum composite likelihood with 1,000 bootstrap iterations. Results: The deduced amino acid sequences of the msp-1 of P knowlesi, P cynomolgi and P vivax exhibit sequence similarity, ranging from 56.2 to 60.8%. Variable blocks detected in Pkmsp-1 and Pcymsp-1 are located in regions corresponding to variable blocks of Pvmsp-1. Sliding window plots of Dxy along the entire coding regions of the msp-1 genes gave similar profiles for each pair of comparison. Pvmsp-1 is more closely related to Pcymsp-1 than that of Pkmsp-1 based on a phylogenetic analysis. However, the Tajima's relative rate test suggests that the merozoite surface protein 1 (msp-1) of each species has not evolved at the same rate. The McDonald-Kreitman test detects positive selection on regions equivalent to blocks 1 and 9 of Pvmsp-1. Conclusion: The msp-1 genes of P knowlesi, P cynomolgi and P. vivax exhibit a similar pattern of sequence variation. Regions equivalent to conserved blocks 1 and 9 of Pvmsp-1 have evolved under positive selective pressure, suggestive of functional importance probably as targets for host immune responses. C1 [Putaporntip, Chaturong; Hongsrimuanga, Thongchai; Jongwutiwes, Somchai] Chulalongkorn Univ, Dept Parasitol, Fac Med, Bangkok 10330, Thailand. [Seethamchai, Sunee] Naresuan Univ, Dept Biol, Fac Sci, Phitsanulok 65000, Thailand. [Suvannadhat, Vit] Christian Univ Thailand, Fac Sci & Technol, Sch Technol Med, Nakhon Pathom 73000, Thailand. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Putaporntip, C (reprint author), Chulalongkorn Univ, Dept Parasitol, Fac Med, Bangkok 10330, Thailand. EM fmedcpt@md2.md.chula.ac.th NR 36 TC 2 Z9 2 U1 0 U2 1 PU CHULALONGKORN UNIV, FAC MED PI BANGKOK PA CHULALONGKORN UNIV, FAC MED, 1873, RAMA 4, BANGKOK, 10330, THAILAND SN 1905-7415 J9 ASIAN BIOMED JI Asian Biomed. PD APR PY 2008 VL 2 IS 2 BP 123 EP 134 PG 12 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 318US UT WOS:000257118900005 ER PT J AU Gangl, M Kocifaj, M Videen, G Horvath, H AF Gangl, Martin Kocifaj, Miroslav Videen, Gorden Horvath, Helmuth TI Light absorption by coated nano-sized carbonaceous particles SO ATMOSPHERIC ENVIRONMENT LA English DT Article; Proceedings Paper CT Conference on Visibility, Aerosols, and Atmospheric Optics CY SEP 03-06, 2006 CL Vienna, AUSTRIA DE nano-sized aerosols; absorption; coated carbonaceous particles; discrete dipole approximation ID OPTICAL-PROPERTIES; SCATTERING; AEROSOL; SOOT; GRAINS; COEFFICIENT; CALIBRATION; EXTINCTION; SPHERES AB The optical properties of strongly absorbing soot particles coated by transparent material are investigated experimentally and described by several modeling approaches. Soot is produced by spark discharge and passed through a Sinclair-La Mer generator where non-absorbing carnauba wax is condensed onto it to obtain internal soot-wax mixtures in a controlled way. Measurements of the extinction and volume scattering coefficient show an amplification of absorption by a factor of approximately 1.8. This behavior was described by different approaches of internally mixed materials for the modal diameters of the measured size distributions: concentric-sphere model, effective medium approximations and heterogeneous ellipsoids. The concentric-sphere model describes the absorption increase quantitatively; and hence, it is chosen to be applied to the entire particle population in the size distribution. The growth of the soot particles by condensing wax is described by a simplified growth model to estimate the different contributions of several soot particle diameters to the overall absorption cross-section. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Gangl, Martin; Horvath, Helmuth] Univ Vienna, Inst Expt Phys, A-1090 Vienna, Austria. [Kocifaj, Miroslav] Slovak Acad Sci, ICA SAS, Bratislava 84503, Slovakia. [Videen, Gorden] USA, Res Lab, AMSRD ARL CI EM, Adelphi, MD 20783 USA. RP Gangl, M (reprint author), Univ Vienna, Inst Expt Phys, Boltzmanngasse 5, A-1090 Vienna, Austria. EM martin.gangl@univie.ac.at; kocifaj@savba.sk; gvideen@arl.army.mil NR 38 TC 16 Z9 17 U1 0 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 J9 ATMOS ENVIRON JI Atmos. Environ. PD APR PY 2008 VL 42 IS 11 BP 2571 EP 2581 DI 10.1016/j.atmosenv.2007.05.030 PG 11 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 315IU UT WOS:000256872800002 ER PT J AU Knapik, JJ Darakjy, S Swedler, D Amoroso, P Jones, BH AF Knapik, Joseph J. Darakjy, Salima Swedler, David Amoroso, Paul Jones, Bruce H. TI Parachute ankle brace and extrinsic injury risk factors during parachuting SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE wind; combat load; night; entanglements; risk factors; epidemiology; airborne; military personnel ID LANDING INJURIES; MILITARY; BATTALION; ALTITUDE; SPRAINS; FEMALE; JUMPS AB Introduction: This study examined the injury prevention effectiveness of the parachute ankle brace (PAB) while controlling for known extrinsic risk factors. Methods: Injuries among airborne students who wore the PAB during parachute descents were compared with injuries among those who did not. Injury risk factors from administrative records included wind speed, combat loads, and time of day (day/night). Injuries were collected in the drop zone. Results: A total of 596 injuries occurred in 102,784 parachute descents. In univariate analysis, students not wearing the PAB (Controls) were 2.00 [95% confidence interval (95% CI) = 1.32-3.02] times more likely to experience an ankle sprain, 1.83 (95% CI = 1.04-3.24) times more likely to experience an ankle fracture, and 1.92 (95% CI = 1.38-2.67) times more likely to experience an ankle injury of any type. PAB wearers and Controls had a similar incidence of lower body injuries exclusive of the ankle [risk ratio (Control/PAB) = 0.92, 95% CI = 0.65-1.30]. After accounting for known extrinsic injury risk factors, Controls were 1.90 (95% CI = 1.24-2.90) times more likely than PAB wearers to experience an ankle sprain, 1.47 (95% CI = 0.82-2.63) times more likely to experience an ankle fracture, and 1.75 (95% CI = 1.25-2.48) times more likely to experience an ankle injury of any type. The incidence of parachute entanglements that persisted until the jumpers reached the ground were similar among PAB wearers and Controls [RR (Control/PAB) = 1.17, 95% CI = 0.61-2.29]. Conclusion: After controlling for known injury risk factors, the PAB protected against ankle injuries, and especially ankle sprains, while not influencing parachute entanglements or lower body injuries exclusive of the ankle. C1 [Knapik, Joseph J.; Darakjy, Salima; Swedler, David; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. [Amoroso, Paul] Madigan Army Med Ctr, Dept Clin Invest, Tacoma, WA 98431 USA. RP Knapik, JJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, 1570 Stark Rd, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@apg.amedd.army.mil NR 26 TC 17 Z9 20 U1 1 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 2008 VL 79 IS 4 BP 408 EP 415 DI 10.3357/ASEM.2218.2008 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 282CP UT WOS:000254545500006 PM 18457298 ER PT J AU Andreas, EL Geiger, CA Trevino, G Claffey, KJ AF Andreas, Edgar L. Geiger, Cathleen A. Trevino, George Claffey, Kerry J. TI Identifying nonstationarity in turbulence series SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE atmospheric surface layer; cloud forcing; integral scale; nonstationarity; time-dependent memory method (TDM method); time series analysis ID ATMOSPHERIC SURFACE-LAYER; BOUNDARY-LAYER; TEMPERATURE RAMPS; FLUX MEASUREMENTS; SCALE; HEAT; STATISTICS; AIRCRAFT; ERRORS; ENOUGH AB Because of rapid forcing by varying cloud and sky conditions, turbulence time series collected in the atmospheric surface layer over land may often be nonstationary. The meteorological community, however, has no consensus definition of what nonstationarity is and, thus, no consensus method for how to identify it. This study, therefore, adopts definitions for first-order and second-order stationarity taken from the time series analysis literature and implements new analysis techniques and probabilistic tests to quantify first-order and second-order nonstationarity. First-order nonstationarity manifests as a change in the series mean; second-order nonstationarity, as a change in the variance. The analysis identifies nonstationarity in surface-level turbulent temperature and water vapour series collected during two sample days with solar forcing influenced by cirrus and cirrostratus clouds, but that nonstationarity is not as severe as expected despite the rapid thermal forcing by these clouds. On the other hand, even with negligible cloud forcing, both sample days exhibited severe nonstationarity at night. C1 [Andreas, Edgar L.] NW Res Associates Inc, Seattle Div, Lebanon, NH 03766 USA. [Geiger, Cathleen A.] Univ Delaware, Ctr Climate Res, Dept Geog, Newark, DE USA. [Trevino, George] CHIRES Inc, San Antonio, TX USA. [Claffey, Kerry J.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Andreas, EL (reprint author), NW Res Associates Inc, Seattle Div, 25 Eagle Ridge, Lebanon, NH 03766 USA. EM eandreas@nwra.com NR 43 TC 12 Z9 13 U1 0 U2 7 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD APR PY 2008 VL 127 IS 1 BP 37 EP 56 DI 10.1007/s10546-007-9252-z PG 20 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 267QN UT WOS:000253524400003 ER PT J AU Newsom, R Calhoun, R Ligon, D Allwine, J AF Newsom, Rob Calhoun, Ron Ligon, David Allwine, Jerry TI Linearly organized turbulence structures observed over a suburban area by dual-Doppler lidar SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE coherent structures; Doppler lidar; horizontal winds; integral length scale; urban flow ID PLANETARY BOUNDARY-LAYER; ATMOSPHERIC SURFACE-LAYER; COHERENT STRUCTURES; FLOW; DYNAMICS; CASES-99; WIND AB Dual-Doppler lidar observations are used to investigate the structure and evolution of surface-layer flow over a suburban area. The observations were made during the Joint Urban 2003 (JU2003) field experiment in Oklahoma City, U.S.A. in the summer of 2003. This study focuses specifically on a 10-h sequence of scan data beginning shortly after noon local time on 7 July 2003. During this period two coherent Doppler lidars performed overlapping low elevation angle sector scans upwind and south of Oklahoma City's central business district. Radial velocity data from the two lidars are processed to reveal the structure and evolution of the horizontal velocity field in the surface layer throughout the afternoon and during the evening transition period. The retrieved velocity fields clearly show a tendency for turbulence structures to be elongated in the direction of the mean flow throughout the entire 10-h study period. In order to quantify the observed anisotropy and its dependence on stability, integral length scales are estimated directly from the spatially resolved velocity retrievals. As the flow became more stably stratified the characteristic cross-stream dimension of the linear structures decreased. The streamwise component was consistently more anisotropic than the cross-stream component, and both velocity components exhibited maximum anisotropy under neutral conditions. The ratio of the streamwise to cross-stream length scale was estimated to be about eight for the streamwise component, and four for the cross-stream component under neutral conditions. C1 [Newsom, Rob; Allwine, Jerry] Pacific NW Natl Lab, Richland, WA 99352 USA. [Calhoun, Ron] Arizona State Univ, Dept Mech & Aerosp Engn, Tempe, AZ 85287 USA. [Ligon, David] USA, Res Lab, Adelphi, MD USA. RP Newsom, R (reprint author), Pacific NW Natl Lab, Richland, WA 99352 USA. EM rob.newsom@pnl.gov NR 35 TC 35 Z9 35 U1 0 U2 13 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD APR PY 2008 VL 127 IS 1 BP 111 EP 130 DI 10.1007/s10546-007-9243-0 PG 20 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 267QN UT WOS:000253524400007 ER PT J AU Xue, F Hilakivi-Clarke, LA Maxwell, GL Hankinson, SE Michels, KB AF Xue, F. Hilakivi-Clarke, L. A. Maxwell, G. L. Hankinson, S. E. Michels, K. B. TI Longitudinal study on birthweight and the incidence of endometrial cancer SO BRITISH JOURNAL OF CANCER LA English DT Article DE endometrial cancer; birthweight; early life exposure; menopause; anthropometrics ID GROWTH-FACTOR-I; BREAST-CANCER; WOMEN; INSULIN; LIFE; SIZE; RISK AB From 1976 to 2004, we followed 71 751 participants of the Nurses' Health Study and identified 676 invasive endometrial cancer cases. Birthweight, assessed in 1992, was not associated with the incidence of endometrial cancer. No effect modification by menopausal status was observed, but statistical power to detect an interaction was limited. C1 [Xue, F.; Michels, K. B.] Harvard Univ, Brigham & Womens Hosp, Dept Obstet Gynecol & Reprod Biol, Obstet & Gynecol Epidemiol Ctr, Boston, MA 02115 USA. [Xue, F.; Hankinson, S. E.; Michels, K. B.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Hilakivi-Clarke, L. A.] Georgetown Univ, Washington, DC 20057 USA. [Maxwell, G. L.] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. [Hankinson, S. E.; Michels, K. B.] Harvard Univ, Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA. [Hankinson, S. E.; Michels, K. B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. RP Xue, F (reprint author), Harvard Univ, Brigham & Womens Hosp, Dept Obstet Gynecol & Reprod Biol, Obstet & Gynecol Epidemiol Ctr, Boston, MA 02115 USA. EM n2fei@channing.harvard.edu FU NCI NIH HHS [CA87969, P01 CA087969] NR 18 TC 5 Z9 5 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0007-0920 J9 BRIT J CANCER JI Br. J. Cancer PD APR 1 PY 2008 VL 98 IS 7 BP 1288 EP 1291 DI 10.1038/sj.bjc.6604304 PG 4 WC Oncology SC Oncology GA 282IF UT WOS:000254560400019 PM 18349833 ER PT J AU Horzempa, J Held, TK Cross, AS Furst, D Qutyan, M Neely, AN Castric, P AF Horzempa, Joseph Held, Thomas K. Cross, Alan S. Furst, Dana Qutyan, Mohammed Neely, Alice N. Castric, Peter TI Immunization with a Pseudomonas aeruginosa 1244 pilin provides O-antigen-specific protection SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID PSEUDOMONAS-AERUGINOSA-1244 PILIN; ESCHERICHIA-COLI; CONJUGATE VACCINE; INTRANASAL IMMUNIZATION; FRANCISELLA-TULARENSIS; SUBSTRATE-SPECIFICITY; PROTEIN GLYCOSYLATION; TWITCHING MOTILITY; POLYSACCHARIDE; LIPOPOLYSACCHARIDE AB The O antigen is both a major structural outer membrane component and the dominant epitope of most gram-negative bacteria. Pseudomonas aeruginosa 1244 produces a type IV pilus and covalently links an O-antigen repeating unit to each pilin monomer. Here we show that immunization of mice with pure pilin from strain 1244 by use of either the mouse respiratory model or the thermal injury model resulted in protection from challenge with a pilus-null O-antigen-producing 1244 mutant. These results provide evidence that the pilin glycan stimulates a protective response that targets the O antigen, suggesting that this system could be used as the basis for the development of a variety of bioconjugate vaccines protective against gram-negative bacteria. C1 [Horzempa, Joseph; Furst, Dana; Qutyan, Mohammed; Castric, Peter] Duquesne Univ, Dept Biol Sci, Pittsburgh, PA 15282 USA. [Held, Thomas K.; Cross, Alan S.] Walter Reed Army Med Ctr, Dept Bacterial Dis, Washington, DC 20307 USA. [Neely, Alice N.] Shriners Hosp Children, Cincinnati, OH 45229 USA. RP Castric, P (reprint author), Duquesne Univ, Dept Biol Sci, 600 Forbes Ave, Pittsburgh, PA 15282 USA. EM castric@duq.edu FU NIH [AI054929] FX This work was supported by a grant from the NIH to P. C. (grant AI054929).; We thank Antonio DiGiandomenico and Joanna Goldberg for instruction on animal models and for insightful discussion. In addition, we thank Liang Yuan, and Kathleen C. Glazer for technical assistance with the acute-pneumonia model. NR 48 TC 18 Z9 19 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD APR PY 2008 VL 15 IS 4 BP 590 EP 597 DI 10.1128/CVI.00476-07 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 340TB UT WOS:000258666800002 PM 18272666 ER PT J AU Hinds, SR Stack, AL Stocker, DJ AF Hinds, Sidney R., II Stack, Aaron L. Stocker, Derek J. TI Low-iodine diet revisited - Importance in nuclear medicine imaging and management SO CLINICAL NUCLEAR MEDICINE LA English DT Article DE thyroid cancer; low-iodine diet; RAIU; thyroid scintigraphy ID DIFFERENTIATED THYROID-CANCER; THERAPY; ABLATION; REEVALUATION AB Purpose: The need for a low-iodine diet (LID) to maximize the results of radioactive iodine uptake (RAIU), nuclear medicine thyroid scintigraphy, and ultimately treatment of thyroid cancer patients is widely accepted. Failure to follow the prescribed diet can alter RAIU results, thyroid scan findings, and poststudy management. Objective: Provided is a case presentation that illustrates the need for adequate patient understanding and compliance with the LID. Methods: We present the clinical history, laboratory values, and pertinent imaging of a 21-year-old woman with papillary thyroid cancer. The patient's post-thyroidectomy 1-123 and 2 subsequent thyroid (1-123 and post-RAI ablation 1-131) scintigraphy examinations are reviewed as well as the patient's urine iodine levels. Results: In this case of a woman with papillary thyroid cancer, the nuclear medicine whole body and neck pinhole images revealed that compliance to an LID positively impacts the overall management. After an LID was followed, the patient's urine iodine level appropriately declined from the previously elevated level. Initial negative results on thyroid scintigraphy caused by noncompliance with the LID became positive when the patient adhered to the prescribed dietary regimen. Conclusion: An LID is an integral element in the management of differentiated thyroid cancer. Proper guidance and emphasis on the implementation of the diet needs to be provided to patients. Noncompliance may lead to false negative imaging results, misleading the medical professionals and patient. Potentially inadequate management of the patient's thyroid cancer may follow. C1 [Hinds, Sidney R., II; Stack, Aaron L.; Stocker, Derek J.] Walter Reed Army Med Ctr, Nucl Med Serv, Washington, DC 20307 USA. RP Hinds, SR (reprint author), Walter Reed Army Med Ctr, Nucl Med Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM sidney.hinds@na.amedd.army.mil NR 10 TC 7 Z9 7 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD APR PY 2008 VL 33 IS 4 BP 247 EP 250 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 281AI UT WOS:000254468100001 PM 18356660 ER PT J AU Albert, MR Geiger, CA AF Albert, Mary R. Geiger, Cathleen A. TI Guest editorial: Cryospheric science and engineering SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Editorial Material DE cold regions; snow; ice; polar science; polar engineering; cryosphere; cryospheric science; cryospheric engineering; sea ice; robot; ice core; soil freeze-thaw C1 [Albert, Mary R.] USA, Cold Reg Res & Engn Lab, Erdc, Terr & Cryospher Sci Branch, Hanover, NH 03755 USA. [Albert, Mary R.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Geiger, Cathleen A.] Univ Delaware, Dept Geog, Newark, DE USA. RP Albert, MR (reprint author), USA, Cold Reg Res & Engn Lab, Erdc, Terr & Cryospher Sci Branch, 72 Lyme Rd, Hanover, NH 03755 USA. EM Mary.R.Albert@erdc.usace.army.mil OI Albert, Mary/0000-0001-7842-2359 NR 0 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 99 EP 100 DI 10.1016/j.coldregions.2007.11.002 PG 2 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600001 ER PT J AU Marshall, HP Koh, G AF Marshall, Hans-Peter Koh, Gary TI FMCW radars for snow research SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE snow depth; snow stratigraphy; instrumentation; radar; snow hydrology; remote sensing; snow water equivalent; spatial variability ID ACTIVE MICROWAVE SYSTEM; SPATIAL VARIABILITY; CW RADAR; STRATIGRAPHY; COVER; ICE; SURFACE; LAYERS; WET AB Frequency Modulated Continuous Wave (FMCW) radars have been used by snow scientists for the past 30 years. This radar technology provides a promising alternative to point measurements, as properties such as snow depth can be measured quickly and non-destructively. Recent advances in microwave FMCW radar technology have resulted in lightweight, portable instrumentation. This is in contrast to the early FMCW radar systems which were often too heavy to cover large distances efficiently. These advanced FMCW radars provide snow scientists and hydrologists with the ability to map snow pack properties, such as depth, snow water equivalent (SWE) and stratigraphy, rapidly over large distances, at high resolution. We discuss the development of FMCW radar over the past 30 years and review the diverse applications of these radars by snow scientists. (c) 2007 Elsevier B.V. All rights reserved. C1 [Marshall, Hans-Peter] Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO 80309 USA. [Marshall, Hans-Peter; Koh, Gary] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Marshall, HP (reprint author), Univ Colorado, Inst Arctic & Alpine Res, 1560 30th St,Campus Box 450, Boulder, CO 80309 USA. EM marshalh@colorado.edu RI Marshall, Hans-Peter/A-2374-2010 OI Marshall, Hans-Peter/0000-0002-4852-5637 NR 39 TC 30 Z9 30 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 118 EP 131 DI 10.1016/j.coldregions.2007.04.008 PG 14 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600003 ER PT J AU Albert, DG Decato, SN Carbee, DL AF Albert, Donald G. Decato, Stephen N. Carbee, David L. TI Snow cover effects on acoustic sensors SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE snow; acoustics; wave propagation; outdoor sound; porous media; snow permeability; snow cover ID OUTDOOR SOUND-PROPAGATION; FINITE GROUND IMPEDANCE; AIR PERMEABILITY; SURFACE-WAVES; MODELS; PULSES; PLANE; LAYER AB Measurements were conducted to determine the effect of a snow cover on acoustic wave propagation during a 50 day period in Alaska. Acoustic waveforms produced by a blank pistol shot were recorded after propagating horizontally over various snow-covered propagation paths and were used to determine the snow cover parameters by comparison with theoretically calculated waveforms. This automatic comparison procedure was successful in determining the average snow cover permeability and depth even when the snow cover depth varied greatly across the propagation path. Although the snow cover properties remained relatively constant during the measurement period, the acoustic measurements were able to determine the changes caused by wind events and new snowfall. Acoustic measurements can provide a rapid, accurate method for determining and monitoring snow cover characteristics. The excess attenuation produced by the snow cover was generally about -30 dB for 100 in distance and frequencies above 100 Hz. Theoretical calculations also show that even a thin snow cover only 0.02 m thick will affect acoustic pulse propagation. The attenuation and distortion caused by a snow cover can degrade passive acoustic sensor identification and distance estimation, but these detrimental effects can be mitigated by proper design of signal processing algorithms. Published by Elsevier B.V. C1 [Albert, Donald G.; Decato, Stephen N.; Carbee, David L.] Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Albert, DG (reprint author), Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Donald.G.Albert@erde.usace.army.mil NR 46 TC 4 Z9 4 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 132 EP 145 DI 10.1016/j.coldregions.2007.05.009 PG 14 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600004 ER PT J AU Reynolds, CM Ringelberg, DB AF Reynolds, C. M. Ringelberg, D. B. TI Non-indigenous endospore persistence following release in a snow - soil system SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE bacteria; endospore; PLFA ID MICROBIAL COMMUNITIES; SURVIVAL AB Knowledge of snow-soil-microbial interactions could lead to the development of strategies that exploit snow as a delivery system for microorganisms to soil or for nutrients that would in turn influence the soil microbiota. A predictable soil-snow-microbial system could promote or sustain native or introduced microbial activity during periods of snow cover or preserve and preposition viable but inactive microorganisms until conditions become favorable for growth. Knowledge of these manipulations could result in strategies to target desired soil microbial processes. Potential applications include bioremediation and decontamination. We hypothesized that population dynamics at the snow-soil interface would be a determinant in the growth and survival of an introduced species and that the microbial community would not be static. Using replicated field studies, we characterized native microbial populations in a local soil with and without snow cover using molecular-based taxonomic methods. We introduced the bacterial species Bacillus thuringiensis to the soil prior to snowfall and to the snow covering following snowfall. As competition, we also added Pseudomonas syringae to the snow in selected treatments. During a single winter and into the spring, we periodically sampled the snow-soil interface to characterize the prevailing microbial populations. Results showed that micro-eukaryotes, either protists or fungi, increased significantly under snow. P. syringae survival and growth was detected for up to 80 days post-inoculation to snow. B. thuringiensis, added as endospores, remained and survived mainly in the endospore state. (c) 2007 Elsevier B.V. All rights reserved. C1 [Reynolds, C. M.; Ringelberg, D. B.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Reynolds, CM (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM charies.m.reynolds@erdc.usace.army.mil NR 24 TC 3 Z9 3 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 146 EP 154 DI 10.1016/j.coldregions.2007.02.005 PG 9 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600005 ER PT J AU Melloh, RA Richmond, P Shoop, SA Affleck, RT Coutermarsh, BA AF Melloh, Rae A. Richmond, Paul Shoop, Sally A. Affleck, Rosa T. Coutermarsh, Barry A. TI Continuous mapping of distributed snow depth for mobility models using shaped solutions SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE snow distribution; continuous snow property mapping; vehicle performance; shaped solution domain; snow cone AB High-resolution ground vehicle mobility models are used by the U.S. Army to investigate new vehicle concepts, conduct force-on-force simulations, and-in the future-support terrain analysis for battle planning. Use of these models in winter conditions requires a method to realistically represent the distribution of snow depth and density over a landscape. The objective of this work was to develop a method to use a recently identified pinched-cone-shaped solution domain to map snow properties. The method was developed with stringent computational and data storage efficiency requirements in mind and is demonstrated by mapping snow depth on the Ethan Allen Firing Range in northern Vermont, USA. The pinched-cone-shaped plots in a cylindrical coordinate system r=F(theta,z) where the no-slope snow depth is taken as the vertex (0,0), the radii (r) represent the snow depth relative to the no-slope case, and r is a function of azimuth (theta) and terrain slope (z). The pinched-cone equation uses a circular function with one or two coefficients that describe the slope-azimuth-dependent expansion of the pinched cone as snow depth differentiation increases with increased terrain slope. Equations that relate the expansion coefficients and no-slope snow depth to elevation then permit continuous mapping of snow depth with respect to terrain slope, azimuth, and elevation. The mapping is applied within five forest categories (open, sparse, deciduous, mixed, and conifer). The influence of snow depth and terrain slope on vehicle speed predictions is illustrated. Published by Elsevier B.V. C1 [Melloh, Rae A.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Terr & Cryospher Sci Branch, Hanover, NH 03755 USA. [Richmond, Paul] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Mobil Syst Branch, Vicksburg, MS 39180 USA. [Shoop, Sally A.; Affleck, Rosa T.; Coutermarsh, Barry A.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Appl & Mil Engn Branch, Hanover, NH 03755 USA. RP Melloh, RA (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Terr & Cryospher Sci Branch, 72 Lyme Rd, Hanover, NH 03755 USA. EM Rae.A.Melloh@erdc.usace.army.mil; Paul.W.Richmond@erdc.usace.army.mil; Sally.A.Shoop@erdc.usace.army.mil; Rosa.T.Affleck@erdc.usace.army.mil; Barry.A.Coutermarsh@erdc.usace.army.mil NR 16 TC 4 Z9 4 U1 3 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 155 EP 165 DI 10.1016/j.coldregions.2007.06.010 PG 11 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600006 ER PT J AU Weale, J Lever, JH AF Weale, Jason Lever, James H. TI Innovations in over-snow cargo transport SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE over-snow mobility; south pole traverse; cargo sleds; cargo delivery efficiency; heavy cargo traverse; polar logistics AB The United States Antarctic Program (USAP) is developing tractor-sled trains to haul heavy cargo 1600 km from McMurdo Station to South Pole Station. In 2003, the proof-of-concept fleet experienced poor mobility and numerous sled breakdowns when attempting to cross the Ross Ice Shelf Based on in-situ mobility tests, we recommended several expedient changes to the sled trains: tow the sleds outside of the tractor ruts, build larger skis with elliptical noses, and accommodate sled motions via compliant bushings. The USAP adopted these recommendations, the sleds performed well, and the fleet completed its first successful cargo delivery to South Pole in December 2005. For that season, we designed and the fleet successfully trialed a novel fuel sled consisting of a transportable fuel bladder strapped onto a sheet of durable, low-friction plastic. The resulting sled costs about one-quarter that of a steel tank sled, has about one-eighth of the tare weight and increases the expected fuel delivered per tractor almost nine times. The durability of these bladder sleds over rough terrain must yet be assessed, but their high fuel-delivery efficiency, compared with the present method of aircraft delivery, is worth pursuing. For example, a seven-tractor fleet completing three round trips per season could deliver fuel to South Pole equivalent to 92 LC-130 flights while consuming about one-quarter of the fuel required for aircraft delivery. Economic analysis shows that reduced aircraft costs could payoff the capital cost of a traverse fleet within a single season. (c) 2007 Elsevier B.V. All rights reserved. C1 [Weale, Jason; Lever, James H.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Weale, J (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM jason.weale@us.army.mil NR 3 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 166 EP 176 DI 10.1016/j.coldregions.2007.03.006 PG 11 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600007 ER PT J AU Lever, JH Ray, LE AF Lever, J. H. Ray, L. E. TI Revised solar-power budget for Cool Robot polar science campaigns SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE robotic vehicle; over-snow mobility; antarctica; Greenland; autonomous robot ID RADIATION AB Why develop polar robots? Logistics costs predominate polar-science budgets to maintain safe human operations in extreme environments. Robots could reduce this logistics burden and thus expand research opportunities in the Polar Regions. With the funding from the National Science Foundation, we have developed first ground vehicle specifically designed to conduct long-duration autonomous science campaigns over terrestrial ice sheets. The 60-kg, solar-powered Cool Robot measures 1.2 x 1.2 x 1 in and can carry or tow 20-80 kg science payloads. A low-profile, four-wheel-drive chassis supports a five-sided, lightweight box of solar cells that capture significant reflected sunlight from the snowfield. The robot is zero emissions, so it can conduct clean snow and air measurements without being trailed by its own pollutants. A fleet of Cool Robots could support many other polar science projects, including biological sampling, glaciology surveys, and upper atmosphere or magnetosphere observations using broadly spaced instrument arrays. We present here revisions to the Cool Robot's solar-power input model to account for the effects of diffuse-sky radiation, a significant source of radiation for cloudy conditions common in Greenland. The main effect of increasing diffuse-sky radiation, for fixed global radiation, is to increase the diurnal variation in solar-power input to the robot. The revised model agrees well with irradiance measurements and the robot's measured power budget during a long-duration test conducted in Greenland. It thus allows us to adapt the Cool Robot to the specific needs of polar science campaigns with some confidence. For two-month science campaigns in Antarctica or Greenland, the Cool Robot has sufficient power margin to carry a 20-kg payload, or tow an 80-kg sled, over 1000 km per month. Under most conditions, 100-300 W are available to power the payload. The robot must yet demonstrate reliable long-distance operation. Nevertheless, results to date suggest it holds the potential to conduct significant autonomous science campaigns in Antarctica and Greenland. (c) 2007 Elsevier B.V. All rights reserved. C1 [Lever, J. H.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ray, L. E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Lever, JH (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM james.h.lever@erdc.usace.army.mil; laura.e.ray@dartmouth.edu NR 24 TC 10 Z9 13 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 177 EP 190 DI 10.1016/j.coldregions.2007.02.009 PG 14 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600008 ER PT J AU Shoop, S Affleck, R Haehnel, R Janoo, V AF Shoop, Sally Affleck, Rosa Haehnel, Robert Janoo, Vincent TI Mechanical behavior modeling of thaw-weakened soil SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE calibration; constitutive relations; frost; thaw; loose; wet; soft soils; plastic deformation; triaxial shear; direct shear; rolling wheel; pavement; finite element modeling AB Freeze-thaw action produces a loose, wet soil that undergoes large deformation when subjected to vehicle loads and is responsible for "thaw weakening" of pavement systems. Because of the difficulty and expense in large-scale experiments, a finite element analysis was desired for the detailed study of thaw weakening. Neither a material model for thawing soil behavior nor detailed test data for large strains on thaw-weakened soil were available. Therefore, both were developed and are presented here. The material model must be capable of capturing the major behaviors of thawing soil subjected to rapid loading from vehicles in a near-surface condition. A common subgrade soil from New England, which was used in experimental studies of full-scale road sections, was chosen to represent a typical frost-susceptible silty sand. The soil was subjected to a suite of saturated and unsaturated triaxial testing, duplicating the conditions measured during thaw. The triaxial test data was used to calibrate a modified Capped Drucker-Prager plasticity model. The thawed soil material model was validated using independent test data of direct shear on thawed samples. The validated model was then implemented in application simulations of moving vehicle loads (a rolling wheel) on paved and unpaved roads with freeze-thaw layering. (c) 2007 Elsevier B.V. All rights reserved. C1 [Shoop, Sally; Affleck, Rosa; Haehnel, Robert] USA, Cold Reg Res & Engn Lab, Erdc, Hanover, NH 03755 USA. [Janoo, Vincent] United Nations Off Program Serv, Kabul, Afghanistan. RP Shoop, S (reprint author), USA, Cold Reg Res & Engn Lab, Erdc, 72 Lyme Rd, Hanover, NH 03755 USA. EM Sally.A.Shoop@erdc.usace.army.mil NR 16 TC 10 Z9 15 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 191 EP 206 DI 10.1016/j.coldregions.2007.04.023 PG 16 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600009 ER PT J AU Ferrick, MG Mulherin, ND Haehnel, RB Coutermarsh, BA Durell, GD Tantillo, TJ Curtis, LA Clair, TLS Weiser, ES Cano, RJ Smith, TM Martinez, EC AF Ferrick, M. G. Mulherin, N. D. Haehnel, R. B. Coutermarsh, B. A. Durell, G. D. Tantillo, T. J. Curtis, L. A. Clair, T. L. St. Weiser, E. S. Cano, R. J. Smith, T. M. Martinez, E. C. TI Evaluation of ice release coatings at cryogenic temperature for the space shuttle SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE double lap shear testing; cryogenic temperatures; ice adhesion; ice phobic coatings; space shuttle AB The brackets that secure the liquid oxygen feed line to the external tank are known locations of frost and ice growth during the pre-launch period following fuel loading. This experimental program quantified the reduction in adhesion that resulted when ice phobic coatings were applied to test coupons that simulated the bracket surface. Double lap shear testing of coated and uncoated coupons provided robust test specimens and consistent load response patterns with exceptional resolution. Ice was grown as strong and consistently as possible for these tests and then subjected to temperature decreases comparable to those of the bracket. All tests were conducted at a constant temperature of -112 degrees C (-170 degrees F) and included uncoated controls with each group of samples. The program evolved in three phases. Phase I evaluated a wide range of coatings, and showed that Rain-X mixed with MP-55 powdered Teflon (RXM) was an outstanding coating to reduce ice adhesion to Koropon coated aluminum. Coating material retained on the ice surface following each test indicated failure in the coating and the potential for loss of effectiveness with repeated ice formation and release. Phase 2 evaluated modifications to RXM that might enhance durability while maintaining effectiveness. However, the modified mixtures did not improve coating durability or ice release. Phase 3 focused on the effects of mixing method, cure time, wiping off of excess coating, and coating resistance to weathering by water. A progressive coating loss again occurred through repeat test cycles, but performance generally improved. Results also indicated that cure times longer than 1.5 h prior to coating disturbance are needed for optimal performance. The MP-55 remaining on coupon surfaces after 3 cycles of testing and on one untested coupon from the same group was measured with XPS. The tested coupons retained slightly less MP-55 than the untested coupon, confirming the loss of coating. Contact angle analysis of these same coupons showed that the hydrophobic performance of the tested surfaces was largely preserved. Scanning electron microscopy with an energy dispersive spectroscopy elemental map indicated that the MP-55 was evenly dispersed throughout the coated surface, and abrasive wiping did not remove a significant portion of the Teflon. Test results suggest follow-up studies to refine the optimal coating formulation, mixing and application procedures, and understanding of reaction processes, cure time, and coating durability. Double lap shear testing and XPS analysis can quantify ice adhesion and coating profile thickness changes with cycling, and is capable of resolving these remaining issues. (c) 2007 Elsevier B.V. All rights reserved. C1 [Ferrick, M. G.; Mulherin, N. D.; Haehnel, R. B.; Coutermarsh, B. A.; Durell, G. D.; Tantillo, T. J.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Clair, T. L. St.] Natl Inst Aerosp, Hampton, VA USA. [Weiser, E. S.; Cano, R. J.] NASA, Langley Res Ctr, Hampton, VA 23665 USA. [Smith, T. M.] NASA, John F Kennedy Space Ctr, KSC, Kennedy Space Ctr, FL 32899 USA. RP Ferrick, MG (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM michael.g.ferrick@crdc.usace.army.mil NR 5 TC 12 Z9 12 U1 3 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 224 EP 243 DI 10.1016/j.coldregions.2007.03.002 PG 20 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600011 ER PT J AU Reynolds, CM Ringelberg, DB Perry, LB Wagner, GW AF Reynolds, Charles M. Ringelberg, David B. Perry, Lawrence B. Wagner, George W. TI Performance of an emerging all-weather decontamination solution against nerve and mustard agent simulants at subfreezing temperatures SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE decontamination; chemical agents; VX; HD AB Solutions for decontaminating chemical and biological agents should be able to perform in all climatic conditions, including subfreezing temperatures. Below 0 degrees C, aqueous-based decontamination solutions or their components can freeze, rendering them inactive and difficult to handle. Moreover, rates of neutralization will be dramatically slower than at normal room temperature. In a series of replicated laboratory studies, we quantified the efficacy of an emerging decontamination solution, DECON Green, against the VX nerve-agent simulant bis-(2-ethyl hexyl) phosphite and the HD mustard agent simulant 2-chloroethyl phenyl sulfide. The efficacy of the DECON Green formulations was tested at 4, -5 and - 15 degrees C using both contact-hazard assessments and mass balance approaches. Contact-hazard assessments simulated the transfer of simulant to skin. The mass balance approach addressed the fate of simulant by quantifying recovery following each step of the decontamination process. Two formulations of DECON Green were investigated: the "standard" formulation, New DECON Green, and the "cold weather" formulation, CA(2)WT. Simulants were spread on chemical-agent-resistant-coating-treated aluminum disks (CARC coupons). The CARC coupons were subsequently decontaminated using standard U.S. Army operating procedures. At all temperatures investigated, sequential contact hazards of the simulant were three to four times lower in concentration for the mustard simulant and nerve-agent simulant, respectively, following the application of DECON Green and washing than without DECON Green or without washing. The mass balance data showed that washing with a propylene glycol:H2O solution was an important part of the decontamination process. DECON Green both degraded the simulants and increased the simulants removed during washing. These findings indicate that at both - 5 and - 15 degrees C, temperatures at which water-based procedures would be problematic, the cold-formula DECON Green plus washing with propylene glycol:H2O was effective at reducing surface contact hazards from the two chemical agent simulants, (c) 2007 Elsevier B.V. All rights reserved. C1 [Reynolds, Charles M.; Ringelberg, David B.; Perry, Lawrence B.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Washington, DC USA. [Wagner, George W.] Edgewood Chem Biol Ctr, Edgewater, MD USA. RP Reynolds, CM (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Washington, DC USA. EM charles.m.reynolds@erdc.usace.army.mil NR 4 TC 0 Z9 0 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 244 EP 253 DI 10.1016/j.coldregions.2007.02.003 PG 10 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600012 ER PT J AU Phetteplace, G Weale, J AF Phetteplace, Gary Weale, Jason TI A model for freeze-thaw cycling of the South Pole Station exterior sheathing SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Antarctica; South Pole; solar flux; heat transfer; freeze-thaw cycling; moisture accumulation AB An infrared survey [Phetteplace, G. 2006. An Infrared Survey of the South Pole Station Modernization Project, Final Project Report to National Science Foundation, US Army Cold Regions Research and Engineering Laboratory, Hanover, NH.] of the new South Pole Elevated Station revealed evidence of excessive air exfiltration in some locations. Despite the relatively low indoor humidity normal in the South Pole Station, typically less than 10% relative humidity (RH), there was concern that excessive exfiltration could result in moisture accumulation within the building walls. While the accumulation and freezing of moisture at any point in the wall section could be problematic, what was felt to be of greater concern was the potential for repeated freeze-thaw cycling near the exterior oriented strand board (OSB) sheathing due to the significant diurnal temperature cycling of the siding during the Antarctic summers. The intense solar radiation conditions on vertical surfaces at the low Antarctic summer sun angles results in very high solar fluxes, and surface temperatures can rise well above freezing even in ambient temperatures that are -20 degrees C or lower. Typical building energy analysis methods are not suited to analysis of this problem for a variety of reasons. Thus we constructed a finite difference heat transfer model of the wall section with a full compliment of realistic boundary conditions for the South Pole application. The base case of the planned wall section and various potential retrofits were evaluated with the model using actual weather data for six summer seasons. The results show that under the worse case summer season the base case wall section would see approximately 44 freeze-thaw cycles. That number would be reduced to only 12 with the addition of either 25 mm of extruded polystyrene foam insulation, or 19 mm of plywood and 13 mm of the same insulation. Over a 25 year period these same additions to the exterior of the building would reduce the number of freeze-thaw cycles by over a factor of six. (c) Published by Elsevier B.V. C1 [Phetteplace, Gary; Weale, Jason] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Phetteplace, G (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM phet@valley.net NR 12 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD APR PY 2008 VL 52 IS 2 BP 254 EP 261 DI 10.1016/j.coldregions.2007.05.007 PG 8 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 291YX UT WOS:000255234600013 ER PT J AU Murray, CK Hospenthal, DR AF Murray, Clinton K. Hospenthal, Duane R. TI Acinetobacter infection in the ICU SO CRITICAL CARE CLINICS LA English DT Article ID INTENSIVE-CARE-UNIT; VENTILATOR-ASSOCIATED PNEUMONIA; GRAM-NEGATIVE BACILLI; SPECTRUM BETA-LACTAMASE; MULTIDRUG-RESISTANT; BAUMANNII BACTEREMIA; RISK-FACTORS; POLYMYXIN-B; PSEUDOMONAS-AERUGINOSA; ATTRIBUTABLE MORTALITY AB Acinetobacter is a formidable challenge to managing critically ill patients. This pathogen's ability to rapidly develop antimicrobial resistance to all currently available antimicrobial agents is concerning because increasing data support attributable mortality to these bacteria when associated with hospitalized patients with comorbidities and severe illness. The role of dual therapy is currently unclear and might be associated with increased toxicities without proven synergy or ability to prevent the development of resistance. Infection control and antibiotic control measures might have the greatest impact on these bacteria. Continued efforts are needed to develop new antimicrobial agents against this pathogen and assess the ideal currently available agents. C1 [Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil NR 84 TC 15 Z9 17 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-0704 J9 CRIT CARE CLIN JI Crit. Care Clin. PD APR PY 2008 VL 24 IS 2 BP 237 EP + DI 10.1016/j.ccc.2007.12.005 PG 13 WC Critical Care Medicine SC General & Internal Medicine GA 291XK UT WOS:000255230400002 PM 18361943 ER PT J AU Maggio, KL Kalasinsky, VF Lewin-Smith, MR Mullick, FG AF Maggio, Kurt L. Kalasinsky, Victor F. Lewin-Smith, Michael R. Mullick, Florabel G. TI Wound fragments from cutaneous sites of U.S. Military personnel deployed in Operation Iraqi Freedom: Clinical aspects and pathologic characterizations SO DERMATOLOGIC SURGERY LA English DT Article ID FOREIGN-BODY; INJURY; MANAGEMENT; EXPLOSION; BULLETS; TISSUE AB BACKGROUND A wide variety of materials present in current military conflict zones may be implanted and retained as "foreign bodies" or fragments in wounds. Analysis of removed fragments can be valuable to the patient, for research purposes, and for the protection of future potential victims. OBJECTIVES The objectives were to evaluate the composition of retained fragments in wounds from combat injuries and correlate this information with the mechanism of injury. METHODS Wound fragments from 10 U. S. military personnel wounded while deployed in Iraq for Operation Iraqi Freedom were removed from their skin and were subjected to gross examination, light microscopy, and scanning electron microscopy/energy-dispersive X-ray analysis (SEM-EDXA), with specimen radiography and infrared spectroscopy if indicated. RESULTS A variety of exogenous substances, including iron, lead, antimony, copper, aluminum, and acrylonitrile-styrene plastic were detected. No (depleted) uranium was detected. There was a high degree of correlation between the composition of the fragment removed and the wounding event. CONCLUSIONS Wound fragments may take months to years to manifest. Their gross appearance can be misleading. Establishing the composition of retained materials in wounds may assist in the clinical care of the wounded, provide forensic information, and have broader value in wound analysis and research. C1 [Maggio, Kurt L.] Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. [Kalasinsky, Victor F.; Lewin-Smith, Michael R.; Mullick, Florabel G.] Armed Forces Inst Pathol, Dept Environm & Infect Dis Sci, Washington, DC 20306 USA. RP Maggio, KL (reprint author), Walter Reed Army Med Ctr, Dept Dermatol, Clin 1J,6900 Georgia Ave NW, Washington, DC 20307 USA. EM kurt.maggio@na.amedd.army.mil NR 23 TC 10 Z9 11 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD APR PY 2008 VL 34 IS 4 BP 475 EP 482 DI 10.1111/j.1524-4725.2007.34093.x PG 8 WC Dermatology; Surgery SC Dermatology; Surgery GA 280GI UT WOS:000254413300004 PM 18248468 ER PT J AU Bennett, JW Murray, CK Holmes, RL Patterson, JE Jorgensen, JH AF Bennett, Jason W. Murray, Clinton K. Holmes, Robert L. Patterson, Jan E. Jorgensen, James H. TI Diminished vancomycin and daptomycin susceptibility during prolonged bacteremia with methicillin-resistant Staphylococcus aureus SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE vancomycin tolerance; daptomycin resistance; MRSA bacteremia; minimum inhibitory concentration; bactericidal effect ID BACTERICIDAL ACTIVITY; GLYCOPEPTIDE TOLERANCE; ANTIBIOTIC TOLERANCE; IN-VIVO; STRAINS; ENDOCARDITIS; EFFICACY AB An elderly patient with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was treated sequentially with vancomycin plus rifampin then daptomycin plus gentamicin. The MRSA strain developed diminished susceptibility to vancomycin (MIC increase and tolerance), daptomycin, and gentamicin, and resistance to rifampin during therapy. (C) 2008 Elsevier Inc. All rights reserved. C1 [Bennett, Jason W.; Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis MCHE MDI, Dept Med, Ft Sam Houston, TX 78234 USA. [Holmes, Robert L.] Wilford Hall USAF Med Ctr, Dept Infect Dis, San Antonio, TX 78201 USA. [Patterson, Jan E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med Infect Dis & Pathol, San Antonio, TX 78229 USA. [Patterson, Jan E.] S Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA. [Jorgensen, James H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. RP Bennett, JW (reprint author), Brooke Army Med Ctr, Infect Dis MCHE MDI, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jason.bennett@amedd.army.mil RI Valle, Ruben/A-7512-2013 NR 22 TC 17 Z9 17 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD APR PY 2008 VL 60 IS 4 BP 437 EP 440 DI 10.1016/j.diagmicrobio.2007.11.002 PG 4 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 282KA UT WOS:000254565300019 PM 18096352 ER PT J AU Grant, KW Elhilali, M Shamma, SA Walden, BE Surr, RK Cord, MT Summers, V AF Grant, Ken W. Elhilali, Mounya Shamma, Shihab A. Walden, Brian E. Surr, Rauna K. Cord, Mary T. Summers, Van TI An objective measure for selecting microphone modes in OMNI/DIR hearing aid circuits SO EAR AND HEARING LA English DT Article; Proceedings Paper CT 17th Annual Convention of the American-Academy-of-Audiology CY APR, 2005 CL Washington, DC SP Amer Acad Audiol ID SPEECH TRANSMISSION INDEX; DIRECTIONAL-MICROPHONE; INTELLIGIBILITY; NOISE; REVERBERATION; MODULATIONS AB Objectives: Studies have shown that listener preferences for omnidirectional (OMNI) or directional (DIR) processing in hearing aids depend largely on the characteristics of the listening environment, including the relative locations of the listener, signal sources, and noise sources; and whether reverberation is present. Many modern hearing aids incorporate algorithms to switch automatically between microphone modes based on an analysis of the acoustic environment. Little work has been done, however, to evaluate these devices with respect to user preferences, or to compare the outputs of different signal processing algorithms directly to make informed choices between the different microphone modes. This study describes a strategy for automatically switching between DIR and OMNI microphone modes based on a direct comparison between acoustic speech signals processed by DIR and OMNI algorithms in the same listening environment. In addition, data are shown regarding how a decision to choose one microphone mode over another might change as a function of speech to noise ratio (SNR) and spatial orientation of the listener. Design: Speech and noise signals were presented at a variety of SNR's and in different spatial orientations relative to a listener's head. Monaural recordings, made in both OMNI and DIR microphone processing modes, were analyzed using a model of auditory processing that highlights the spectral and temporal dynamics of speech. Differences between OMNI and DIR processing were expressed in terms of a modified spectrotemporal modulation index (mSTMI) developed specifically for this hearing aid application. Differences in mSTMI values were compared with intelligibility measures and user preference judgments made under the same listening conditions. Results: A comparison between the results of the mSTMI analyses and behavioral data (intelligibility and preference judgments) showed excellent agreement, especially in stationary noise backgrounds. In addition, the mSTMI was found to be sensitive to changes in SNR as well as spatial orientation of the listener relative to signal and noise sources. Subsequent mSTMI analyses on hearing aid recordings obtained from real-life environments with more than one talker and modulated noise backgrounds also showed promise for predicting the preferred microphone setting in varied and complex listening environments. C1 [Grant, Ken W.; Walden, Brian E.; Surr, Rauna K.; Cord, Mary T.; Summers, Van] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Elhilali, Mounya; Shamma, Shihab A.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RP Grant, KW (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM grant@tidalwave.net RI Shamma, Shihab/F-9852-2012; Elhilali, Mounya/A-3396-2010 OI Elhilali, Mounya/0000-0003-2597-738X NR 35 TC 5 Z9 5 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0196-0202 J9 EAR HEARING JI Ear Hear. PD APR PY 2008 VL 29 IS 2 BP 199 EP 213 PG 15 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 275IC UT WOS:000254064100006 PM 18595186 ER PT J AU Pan, E Zhang, Y Chung, PW AF Pan, E. Zhang, Y. Chung, P. W. TI BEM calculation of strain energy density and relative strain energy in QWR nanostructures SO ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS LA English DT Article DE BEM; QWR; bimaterial; Green's function; strain energy; Stroh formalism; InAs; GaAs ID BOUNDARY-ELEMENT METHOD; PIEZOELECTRIC MATERIALS; INTERFACIAL CRACKS; FRACTURE-MECHANICS; GREENS-FUNCTIONS; QUANTUM DOTS; BI-MATERIAL; INCLUSIONS; SIMULATION; SOLIDS AB In this paper, we propose a bimaterial boundary element method (BEM) for the calculation of the strain energy density and the relative strain energy in quantum wire (QWR) nanostructures. We first derive the bimaterial Green's functions in terms of the Stroh formalism. We then discretize the boundary of the problem with constant elements for which the involved Green's function kernels can be exactly integrated. Our bimaterial BEM program is finally applied to calculate the strain energy density and relative strain energy in free-standing/embedded InAs QWR on/in GaAs substrate. For a square InAs (1 1 1) QWR, it is found that the magnitude of the relative strain energy increases with increasing depth of the QWR with respect to the surface of the GaAs (1 1 1) substrate. For an isosceles triangle of InAs (1 1 1) QWR free-standing on the surface of the GaAs (1 1 1) substrate, we found that the magnitude of the relative strain energy increases with increasing base angle of the triangle QWR. Strain energy density inside the InAs QWR is also plotted to show its strong dependence on the QWR shape. These results could be useful to the control of the QWR shape and size in epitaxial growth (C) 2007 Elsevier Ltd. All rights reserved. C1 [Pan, E.; Zhang, Y.] Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. [Pan, E.; Zhang, Y.] Univ Akron, Dept Appl Math, Akron, OH 44325 USA. [Chung, P. W.] USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pan, E (reprint author), Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. EM pan2@uakron.edu RI Pan, Ernian/F-4504-2011 OI Pan, Ernian/0000-0001-6640-7805 NR 32 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0955-7997 J9 ENG ANAL BOUND ELEM JI Eng. Anal. Bound. Elem. PD APR PY 2008 VL 32 IS 4 BP 328 EP 335 DI 10.1016/j.enganabound.2007.07.009 PG 8 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 298GS UT WOS:000255675000007 ER PT J AU Thorn, KA Pennington, JC Kennedy, KR Cox, LG Hayes, CA Porter, BE AF Thorn, Kevin A. Pennington, Judith C. Kennedy, Kay R. Cox, Larry G. Hayes, Charolett A. Porter, Beth E. TI N-15NMR study of the immobilization of 2,4-and 2,6-dinitrotoluene in AeFohic compost SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID COVALENT BINDING; NMR-SPECTROSCOPY; 2,4,6-TRINITROTOLUENE; SOIL; 2,4-DINITROTOLUENE; REDUCTION; STABILITY; FATE; BIOTRANSFORMATION; DINITROTOLUENES AB Large-scale aerobic windrow composting has been used to bioremediate washout lagoon soils contaminated with the explosives TNT (2,4,6-trinitrotoluene) and RDX (hexahydro-1,3,5trinitro-1,3,5-triazine) at several sites within the United States. We previously used N-15 NMR to investigate the reduction and binding of (TNT)-N-15 in aerobic bench -scale reactors simulating the conditions of windrow composting. These studies have been extended to 2,4-dinftrotoluene (2,4DNT) and 2,6-dinitrotoluene (2,6DNT), which, as impurities in TNT, are usually present wherever soils have been contaminated with TNT. Liquid-state 15N NMR analyses of laboratory reactions between 4-methyl-3nitroaniline-N-15,the major monoamine reduction productof 2,4DNT, and the Elliot soil humic acid, both in the presence and absence of horseradish peroxidase, indicated that the amine underwent covalent binding with quinone and other carbonyl groups in the soil humic acid to form both heterocyclic and nonheterocyclic condensation products. Uquid-state 15N NMR analyses of the methanol extracts of 20 day aerobic benchscale composts of 2,4-di-15N-nitrotoluene and 2,6-di-(15)Nnitrotoluene revealed the presence of nitrite and monoamine, but not diamine, reduction products, indicating the occurrence of both dioxygenase enzyme and reductive degradation pathways. Solid-state CP/MAS 15N NMR analyses of the whole composts, however, suggested that reduction to monoamines followed by covalent binding of the amines to organic matter was the predominant pathway. C1 [Thorn, Kevin A.; Kennedy, Kay R.; Cox, Larry G.] US Geol Survey, Denver Fed Ctr, Denver, CO 80225 USA. [Pennington, Judith C.] USA, Res & Dev Ctr, Vicksburg, MS 39180 USA. [Hayes, Charolett A.; Porter, Beth E.] DynTel Corp, Vicksburg, MS 39180 USA. RP Thorn, KA (reprint author), US Geol Survey, Denver Fed Ctr, MS 408, Denver, CO 80225 USA. EM kathorn@usgs.gov NR 27 TC 12 Z9 12 U1 3 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR 1 PY 2008 VL 42 IS 7 BP 2542 EP 2550 DI 10.1021/es0720659 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 281JN UT WOS:000254492800054 PM 18504994 ER PT J AU Greenstein, D Bay, S Anderson, B Chandler, GT Farrar, JD Keppler, C Phillips, B Ringwood, A Young, D AF Greenstein, Darrin Bay, Steven Anderson, Brian Chandler, G. Thomas Farrar, J. Daniel Keppler, Charles Phillips, Bryn Ringwood, Amy Young, Diana TI Comparison of methods for evaluating acute and chronic toxicity in marine sediments SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE sediment toxicity; sublethal toxicity; multiple species; acute toxicity ID NEANTHES ARENACEODENTATA ANNELIDA; ESTUARINE AMPHIPOD; CHEMICAL-MIXTURES; CONTAMINATION; POLYCHAETE; BIOASSAY; CALIFORNIA; RANGES; TESTS; BAY AB Sublethal test methods are being used with increasing frequency to measure sediment toxicity, but little is known about the relative sensitivity of these tests compared to the more commonly used acute tests. The present study was conducted to compare the sensitivity of several acute and sublethal methods and to investigate their correlations with sediment chemistry and benthic community condition. Six sublethal methods (amphipod: Leptocheirus plumulosus survival, growth, and reproduction; polychaete: Neanthes arenaceodentata survival and growth; benthic copepod: Amphiascus tenuiremis life cycle; seed clam: Mercenaria mercenaria growth; oyster: Crassostrea virginica lysosome destabilization; and sediment-water interface testing with mussel embryos, Mytilus galloprovincialis) and two acute methods (amphipod survival with Eohaustorius estuarius and L. plumulosus) were used to test split sediment samples from stations in California. The test with Amphiascus proved to be the most sensitive sublethal test and the most sensitive overall, identifying 90% of the stations as toxic. The Leptocheirus 10-d test was the most sensitive of the acute tests, identifying 60% of the stations as toxic. In general, the sublethal tests were not more sensitive to sediments than the acute tests, with the sublethal tests finding an average of 35% of the stations to be toxic while the acute found 44%. Of the sublethal tests, only the Amphiascus endpoints and Neanthes growth significantly (p <= 0.05) correlated with sediment chemical concentrations. Poor correspondence occurred between the toxicity endpoints and the indicators of benthic community condition. Differences in test characteristics such as mode of exposure, species-specific contaminant sensitivity, changes in contaminant bioavailability, and influence of noncontaminant stressors on the benthos may have been responsible for variation in response among the tests and low correspondence with benthic community condition. The influence of these factors cannot be easily predicted, underscoring the need to use multiple toxicity methods, in combination with other lines of evidence, to provide an accurate and confident assessment of sediment toxicity. C1 [Greenstein, Darrin; Bay, Steven; Young, Diana] So Calif Coastal Water Res Project, Costa Mesa, CA 92626 USA. [Anderson, Brian; Phillips, Bryn] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA. [Chandler, G. Thomas] Univ S Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA. [Farrar, J. Daniel] USA, Waterways Expt Stn, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Keppler, Charles] Marine Resources Res Inst, S Carolina Dept Nat Resources, Charleston, SC 29412 USA. [Ringwood, Amy] Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA. RP Greenstein, D (reprint author), So Calif Coastal Water Res Project, 3535 Harbor Blvd,Suite 110, Costa Mesa, CA 92626 USA. EM darring@sccwrp.org NR 48 TC 23 Z9 26 U1 3 U2 14 PU SOC ENVIRONMENTAL TOXICOLOGY & CHEMISTRY-SETAC PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD APR PY 2008 VL 27 IS 4 BP 933 EP 944 DI 10.1897/07-285.1 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 273RX UT WOS:000253950500020 PM 18333680 ER PT J AU Haik, KL Shear, DA Hargrove, C Patton, J Mazei-Robison, M Sandstrom, MI Dunbar, GL AF Haik, Kristi L. Shear, Deborah A. Hargrove, Chad Patton, Jared Mazei-Robison, Michelle Sandstrom, Michael I. Dunbar, Gary L. TI 7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease SO EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY LA English DT Review DE Parkinson's disease; dopamine immunohistochemistry; NADPH-diaphorase staining; spatial learning; water T maze ID NITRIC-OXIDE SYNTHASE; 14-UNIT T-MAZE; NADPH-DIAPHORASE; 6-OHDA LESIONS; NIGROSTRIATAL SYSTEM; MPTP NEUROTOXICITY; BASAL GANGLIA; RAT STRIATUM; GLIAL-CELLS; INHIBITOR 7-NITROINDAZOLE AB Parkinson's disease (PD) is a neurodegenerative disorder in which loss of dopaminergic (DA) neurons (>50%) in the substantia nigra (SN) precede most of the overt motor symptoms, making early diagnosis and treatment interventions difficult. Because PD has been associated with free radicals generated by nitric oxide, this study tested whether treatments of 7-nitroindazole (7NI), a nitric-oxide-synthase inhibitor, could reduce cognitive deficits that often emerge before overt motor symptoms in a presymptomatic rat model of PD. Rats were given intraperitoneal injections of 50 mg/kg 7NI (or vehicle) just before receiving bilateral, intrastriatal injections of the DA-toxin, 6-hydroxydopamine (6-OHDA). The rats were then given a battery of motor tasks, and their learning ability was assessed using a spatial reversal task in a water-T maze. Results indicate that 7NI treatments attenuate 6-OHDA-induced spatial learning deficits and protect against DA cell loss in the SN, suggesting that 7NI may have potential as an early, presymptomatic pharmacotherapy for PD. C1 [Haik, Kristi L.; Shear, Deborah A.; Mazei-Robison, Michelle; Sandstrom, Michael I.; Dunbar, Gary L.] Cent Michigan Univ, Dept Psychol, Neurosci Program, Field Neurosci Lab Restorat Neurol, Mt Pleasant, MI 48859 USA. [Haik, Kristi L.; Hargrove, Chad] No Kentucky Univ, Dept Biol Sci, Neurosci Res Lab, Highland Hts, KY 41099 USA. [Shear, Deborah A.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Mazei-Robison, Michelle] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. RP Haik, KL (reprint author), No Kentucky Univ, Dept Biol Sci, Neurosci Res Lab, SC 245, Highland Hts, KY 41099 USA. EM haikk@exchange.nku.edu FU NCRR NIH HHS [P20 RR 16481] NR 113 TC 12 Z9 14 U1 4 U2 7 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1064-1297 J9 EXP CLIN PSYCHOPHARM JI Exp. Clin. Psychopharmacol. PD APR PY 2008 VL 16 IS 2 BP 178 EP 189 DI 10.1037/1064-1297.16.2.178 PG 12 WC Psychology, Biological; Psychology, Clinical; Pharmacology & Pharmacy; Psychiatry SC Psychology; Pharmacology & Pharmacy; Psychiatry GA 288FB UT WOS:000254970500009 PM 18489022 ER PT J AU Abadie, J DeVan, M Bankson, D AF Abadie, Jude DeVan, Michale Bankson, Daniel TI To what extent are free testosterone (FT) values reproducible between the two Washingtons, and when can calculated FT be used in lieu of direct measurements? SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Abadie, Jude; DeVan, Michale] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Bankson, Daniel] Vet Affairs Hosp, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800566 ER PT J AU Atkins, J Lee, CH Barrows, E Quinn, P Gonzales, R Oliver, J AF Atkins, James Lee, Chae-Hyuk Barrows, Elizabeth Quinn, Peter Gonzales, Raoul Oliver, James TI Dual lumen catheter for heparin-free hemorrhage in rats: design, construction, and use SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Atkins, James; Lee, Chae-Hyuk; Barrows, Elizabeth; Quinn, Peter; Gonzales, Raoul; Oliver, James] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808630 ER PT J AU Baer, L Wade, CE Sillimani, DT Walters, T Wolf, SE Wu, XW AF Baer, Lisa Wade, Charles E. Sillimani, David T. Walters, Thomas Wolf, Steven E. Wu, Xiaowu TI Severe Burn and Disuse Independently Contribute to Reduction in Bone Density in Rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Baer, Lisa; Wade, Charles E.; Sillimani, David T.; Walters, Thomas; Wolf, Steven E.; Wu, Xiaowu] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Wade, Charles E.; Sillimani, David T.; Wolf, Steven E.; Wu, Xiaowu] UTHSCSA, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801005 ER PT J AU Beidleman, BA Fulco, CS Muza, SR Rock, PB Staab, JE Money, A Forte, V Brothers, M Cymerman, A AF Beidleman, Beth A. Fulco, Charles S. Muza, Stephen R. Rock, Paul B. Staab, Janet E. Money, Alison Forte, Vincent Brothers, Michael Cymerman, Allen TI STAGING FOR SIX DAYS AT 2200 M INDUCES PHYSIOLOGIC ADJUSTMENTS THAT MAY BE RESPONSIBLE FOR DECREASING ACUTE MOUNTAIN SICKNESS (AMS) AT 4300 M SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Beidleman, Beth A.; Fulco, Charles S.; Muza, Stephen R.; Staab, Janet E.; Money, Alison; Forte, Vincent; Cymerman, Allen] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Rock, Paul B.] Oklahoma State Univ, Tulsa, OK USA. [Brothers, Michael] USAF Acad, Usafa, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802308 ER PT J AU Blakely, SR Blumberg, J O'Neill, KR Smith, TJ Pikosky, MA Young, AJ AF Blakely, Shirley R. Blumberg, Jeffrey O'Neill, Karen Rene Smith, Tracey J. Pikosky, Matthew A. Young, Andrew J. TI Increased dietary protein attenuates C-reactive protein and creatine kinase responses to exercise-induced energy deficit SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Blakely, Shirley R.] Food & Drug Adm, Ctr Food Safety & Appl Nutr, College Pk, MD USA. [Blumberg, Jeffrey] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. [Smith, Tracey J.; Pikosky, Matthew A.; Young, Andrew J.] USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803127 ER PT J AU Bowman, PD Bynum, JA Klemcke, H AF Bowman, Phillip D. Bynum, James A. Klemcke, Harold TI Gene expression analysis of circulating leukocytes of rat strains exhibiting long and short survival times following severe hemorrhage SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bowman, Phillip D.; Bynum, James A.; Klemcke, Harold] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806189 ER PT J AU Bowman, PD Sondeen, JL Prince, DM Bynum, JA AF Bowman, Phillip D. Sondeen, Jill L. Prince, Dale M. Bynum, James A. TI The genetic response of human umbilical vein endothelial cells (HUVEC) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Bowman, Phillip D.; Sondeen, Jill L.; Prince, Dale M.; Bynum, James A.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467806184 ER PT J AU Buxton, TB Runner, RR Herczegh, P McPherson, JC AF Buxton, Thomas Brooks Runner, Royce R. Herczegh, Pal McPherson, James C., III TI Two fluoroquinolone-bisphosphonate (BP) derivatives show similar binding affinity to calcium phosphate (CP) particles, but have different antibacterial activity SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Buxton, Thomas Brooks; Runner, Royce R.] Geneva Fdn, Ft Gordon, GA USA. [Herczegh, Pal] Univ Debrecen, Dept Pharmaceut Chem, H-4012 Debrecen, Hungary. [McPherson, James C., III] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800676 ER PT J AU Calderon, M Ryan, KL Kheirabadi, B Klemcke, HG AF Calderon, M. Ryan, K. L. Kheirabadi, B. Klemcke, H. G. TI Differences among inbred rat strains in hematological and coagulation measures SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Calderon, M.; Ryan, K. L.; Kheirabadi, B.; Klemcke, H. G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804735 ER PT J AU Campbell, K Zahrte, D Jett, M Mendis, C AF Campbell, Katherine Zahrte, Darin Jett, Marti Mendis, Chanaka TI Gene Expression Patterns and Pathway Functions of SEB Induced human PBMC. SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Campbell, Katherine; Zahrte, Darin; Mendis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA. [Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803417 ER PT J AU Convertino, VA Rickards, CA Ryan, KL Cooke, WH AF Convertino, Victor A. Rickards, Caroline A. Ryan, Kathy L. Cooke, William H. TI Autonomic compensation to central hypovolemia monitored with heart period variability SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Convertino, Victor A.; Rickards, Caroline A.; Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cooke, William H.] Univ Texas San Antonio, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801211 ER PT J AU Dubick, MA Barr, JL Christy, RJ Roe, JL Walters, TJ AF Dubick, Michael A. Barr, Johnny L. Christy, Robert J. Roe, Janet L. Walters, Thomas J. TI Effects of Poloxamer 188 (P-188) on antioxidant status in rat skeletal muscle subjected to tourniquet (TK)-induced ischemia/reperfusion (I/R) injury SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Dubick, Michael A.; Barr, Johnny L.; Christy, Robert J.; Roe, Janet L.; Walters, Thomas J.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802316 ER PT J AU Gilhooly, CH Das, SK Golden, JK McCrory, MA Dallal, GE Saltzman, E Kramer, FM Roberts, SB AF Gilhooly, Cheryl Hajduk Das, Sai Krupa Golden, Julie K. McCrory, Megan A. Dallal, Gerard E. Saltzman, Edward Kramer, F. Matthew Roberts, Susan B. TI The effects of a discretionary food allowance during a caloric restriction regimen with provided food SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Dallal, Gerard E.] Tufts Univ, Jean Mayer USDA HNRCA, Biostat Unit, Boston, MA 02111 USA. [McCrory, Megan A.] Purdue Univ, Dept Foods & Nutr, W Lafayette, IN 47907 USA. [Kramer, F. Matthew] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467804821 ER PT J AU Gonzalez, RR Cheuvront, SN Goodman, DA Blanchard, LA Berglund, LG Sawka, MN AF Gonzalez, Richard R. Cheuvront, Samuel N. Goodman, Daniel A. Blanchard, Laurie A. Berglund, Larry G. Sawka, Michael N. TI Assessment of a model equation to predict sweating and water requirements SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Gonzalez, Richard R.] New Mexico State Univ, Las Cruces, NM 88003 USA. [Gonzalez, Richard R.] Gonzalez Adv Biophys Assoc, San Lorenzo, NM USA. [Cheuvront, Samuel N.; Goodman, Daniel A.; Blanchard, Laurie A.; Berglund, Larry G.; Sawka, Michael N.] USA, Res Inst Env Med, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800755 ER PT J AU Hammamieh, R Hellman, M Jett, M AF Hammamieh, Rasha Hellman, Matthew Jett, Marti TI Development of Algorithms for High Throughput "Omics" Data Mining and Classification SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hammamieh, Rasha; Hellman, Matthew; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809425 ER PT J AU Hammamieh, R Sumaida, D Miller, S Lin, YX Morris, S Jett, M AF Hammamieh, Rasha Sumaida, Dena Miller, Stacy Lin, Yixin Morris, Sam Jett, Marti TI Identification of a New Target in the Interactions between Staphylococcal Enterotoxin B with the Renal Proximal Tubule Epithelial Cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hammamieh, Rasha; Sumaida, Dena; Miller, Stacy; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. [Lin, Yixin; Morris, Sam] Axela Biosensors Inc, Toronto, ON, Canada. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802785 ER PT J AU Hammers, DW Adamo, M Walters, T Farrar, RP AF Hammers, David W. Adamo, Martin Walters, Tom Farrar, Roger P. TI Decreased induction of heat-shock proteins with age in ischemia-reperfusion injured skeletal muscle SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Hammers, David W.; Farrar, Roger P.] Univ Texas Austin, Austin, TX 78712 USA. [Adamo, Martin] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Walters, Tom] USA, Inst Surg Res, Soft Tissue Injury Lab, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805862 ER PT J AU Harding, MJ Barnaeva, E Bustamante, M Lepus, CM Rahner, C Pober, JS Sjogren, MH Rojkind, M AF Harding, Martha J. Barnaeva, Elena Bustamante, Marcia Lepus, Christin M. Rahner, Christoph Pober, Jordan S. Sjogren, Maria H. Rojkind, Marcos TI Human hepatic stellate cells and hepatocyte co-cultures maintain differentiation in vitro and in vivo SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rahner, Christoph] Yale Univ, Sch Med, Ctr Cellular & Mol Imaging, New Haven, CT USA. [Barnaeva, Elena; Bustamante, Marcia; Rojkind, Marcos] George Washington Univ, Med Ctr, Washington, DC 20037 USA. [Sjogren, Maria H.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809260 ER PT J AU Holt, DB Delaney, RR Hashiro, GM Sato, AK Hernandez, CA Uyehara, CFT AF Holt, Danielle Boudreau Delaney, Richard R. Hashiro, Glenn M. Sato, Aileen K. Hernandez, Claudia A. Uyehara, Catherine F. T. TI Pharmacologic Vasopressin Levels May Protect Renal Function in a Porcine (Sus Scrofa) Model of Vasodilatory Septic Shock SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Holt, Danielle Boudreau; Delaney, Richard R.; Hashiro, Glenn M.; Sato, Aileen K.; Hernandez, Claudia A.; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Dept Clin Invest, Tripler, HI USA. [Holt, Danielle Boudreau; Delaney, Richard R.] Tripler Army Med Ctr, Dept Surg, Tripler, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805362 ER PT J AU Huckstep, OJ Sato, AK Hernandez, CA Uyehara, CFT AF Huckstep, Odaro John Sato, Aileen K. Hernandez, Claudia A. Uyehara, Catherine F. T. TI Water Conservation in Chronic Ethanol Exposure is Associated With Elevated Renal Estrogen Receptor Beta and Vasopressin V2 Receptor mRNA in the Female Rat SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Huckstep, Odaro John; Sato, Aileen K.; Hernandez, Claudia A.; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Tripler, HI USA. [Huckstep, Odaro John] Univ Hawaii, Honolulu, HI 96822 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805542 ER PT J AU Ishida, H Ray, R Ray, P AF Ishida, Hiroshi Ray, Radharaman Ray, Prabhati TI Molecular Approaches to Promote Wound Healing in Sulfur Mustard Exposed Human Keratinocytes In Vitro: Role of Nitric Oxide in Wound Healing SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ishida, Hiroshi; Ray, Prabhati] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ray, Radharaman] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802422 ER PT J AU Jett, M Yourick, D AF Jett, Marti Yourick, Debra TI Laboratory near-peer mentoring of jr/sr high school students by college undergraduates provides experience and incentives to enhance careers in biomedical sciences and STEM SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Jett, Marti; Yourick, Debra] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467809458 ER PT J AU Jitomir, J Chandran, R Shelmadine, B Beavers, K Kerksick, C Wilborn, C Wismann, J Nassar, E Dove, J Galbreath, M Harvey, T La Bounty, P Campbell, B Ferreira, M Cooke, M Iosia, M Rasmussen, C Bowden, R Wilson, R Kreider, R AF Jitomir, Jean Chandran, R. Shelmadine, B. Beavers, K. Kerksick, C. Wilborn, C. Wismann, J. Nassar, E. Dove, J. Galbreath, M. Harvey, T. La Bounty, P. Campbell, B. Ferreira, M. Cooke, M. Iosia, M. Rasmussen, C. Bowden, R. Wilson, R. Kreider, R. TI Medical profile of sedentary women with and without metabolic syndrome (MS) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Jitomir, Jean; Chandran, R.; Shelmadine, B.; Beavers, K.; Wismann, J.; Nassar, E.; Dove, J.; Galbreath, M.; La Bounty, P.; Ferreira, M.; Cooke, M.; Rasmussen, C.; Bowden, R.; Wilson, R.; Kreider, R.] Baylor Univ, Exercise & Sport Nutr Lab, Waco, TX 76798 USA. [Kerksick, C.] Univ Oklahoma, Norman, OK 73019 USA. [Wilborn, C.] Univ Mary Hardin Baylor, Belton, TX USA. [Harvey, T.] US Mil Acad, Ctr Phys Dev Excellence, West Point, NY 10996 USA. [Campbell, B.] Univ S Florida, Exercise & Sport Nutr Lab, Tampa, FL USA. [Iosia, M.] Lee Univ, Cleveland, TN USA. RI Kreider, Richard/O-1804-2014 OI Kreider, Richard/0000-0002-3906-1658 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GY UT WOS:000208467700669 ER PT J AU Karaian, JE Mongan, PD MacDonald, VW Bunger, R AF Karaian, John Edward Mongan, Paul D. MacDonald, Victor W. Bunger, Rolf TI Low Oxygen Affinity Hemoglobin HBOC-201 enables increased Oxygen Uptake (VO2) In Bovine Pulmonary Artery Endothelial Cells (BPAEC) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Karaian, John Edward; Mongan, Paul D.; Bunger, Rolf] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [MacDonald, Victor W.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803728 ER PT J AU Keyser, B Andres, D Benton, B Ray, R AF Keyser, Brian Andres, Devon Benton, Betty Ray, Radharaman TI Fas targeted siRNA markedly attenuates sulfur mustard-induced apoptosis in human airway epithelial cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Keyser, Brian; Andres, Devon; Benton, Betty; Ray, Radharaman] USA, Med Res Inst Chem Def, APG, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802205 ER PT J AU Klemcke, HG Kheirabadi, B Ryan, KL AF Klemcke, H. G. Kheirabadi, B. Ryan, K. L. TI Plasma potassium concentrations after severe controlled hemorrhage in inbred rat strains SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Klemcke, H. G.; Kheirabadi, B.; Ryan, K. L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805121 ER PT J AU McClung, JP Andersen, NE Tarr, TN Stahl, CH Young, AJ AF McClung, James P. Andersen, Nancy E. Tarr, Tyson N. Stahl, Chad H. Young, Andrew J. TI Moderate iron deficiency and physical training affect body fat accretion in growing male rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [McClung, James P.; Andersen, Nancy E.; Tarr, Tyson N.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Stahl, Chad H.] N Carolina State Univ, Raleigh, NC 27695 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801365 ER PT J AU Mendis, C Jett, M AF Mendis, Chanaka Jett, Marti TI Evaluating gene expression patterns induced by SEB and LPS in human PBMCs SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Mendis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA. [Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801254 ER PT J AU Mendis, C Jett, M AF Mendis, Chanaka Jett, Marti TI Investigation of apoptotic related genes in SEB induced human PBMC module SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Mendis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA. [Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801237 ER PT J AU Merritt, EK Walters, TJ Baer, DG Farrar, RP AF Merritt, Edward K. Walters, Thomas J. Baer, David G. Farrar, Roger P. TI Function after repair of skeletal muscle defect with muscle-derived extracellular matrix SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Merritt, Edward K.; Farrar, Roger P.] Univ Texas Austin, Austin, TX 78712 USA. [Walters, Thomas J.; Baer, David G.] USA, Soft Tissue Injury Lab, Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467805511 ER PT J AU Muhie, S Hammamieh, R Yang, D Jett, M AF Muhie, Seid Hammamieh, Rasha Yang, David Jett, Marti TI Gene Profiles of Dengue Virus Targeted Host Biological Processes and Pathologic Markers SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Muhie, Seid; Yang, David; Jett, Marti] Georgetown Univ, Dept Chem, Washington, DC 20057 USA. [Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800824 ER PT J AU Pidcoke, HF Wolf, SE Jones, JA Holcomb, JB Wade, CE AF Pidcoke, Heather F. Wolf, Steven E. Jones, John A. Holcomb, John B. Wade, Charles E. TI Diurnal pattern in endogenous insulin secretion persists in severely injured patients SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Pidcoke, Heather F.; Wolf, Steven E.; Wade, Charles E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Pidcoke, Heather F.; Wolf, Steven E.; Jones, John A.; Holcomb, John B.; Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467808621 ER PT J AU Ray, R Keyser, B Andres, D Hauck, S Benton, B Carpin, C Daher, A Simbulan-Rosenthal, C Rosenthal, D AF Ray, R. Keyser, B. Andres, D. Hauck, S. Benton, B. Carpin, C. Daher, A. Simbulan-Rosenthal, C. Rosenthal, D. TI Human bronchial/tracheal epithelial cells (BEC) are more sensitive than small airway epithelial cells (SAEC) to sulfur mustard-induced apoptosis apparently due to a Fas (death receptor) response amplification loop SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ray, R.; Keyser, B.; Andres, D.; Hauck, S.; Benton, B.; Carpin, C.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Daher, A.; Simbulan-Rosenthal, C.; Rosenthal, D.] Georgetown Univ, Sch Med, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801246 ER PT J AU Rickards, CA Ryan, KL Muniz, GW Moralez, G Convertino, VA AF Rickards, Caroline A. Ryan, Kathy L. Muniz, Gary W. Moralez, Gilbert Convertino, Victor A. TI How many heart beats are enough? A systematic assessment of data length reduction on measures of heart rate variability and complexity SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rickards, Caroline A.; Ryan, Kathy L.; Muniz, Gary W.; Moralez, Gilbert; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801263 ER PT J AU Ronca, AE Tulbert, CD Winn, GG Baer, LA Kleven, GA AF Ronca, April E. Tulbert, Christina D. Winn, Glenn G. Baer, Lisa A. Kleven, Gale A. TI Perinatal asphyxia induces hyperemotionality and elevates corticosterone (CORT) release in response to novel stimuli in later life SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ronca, April E.; Tulbert, Christina D.; Winn, Glenn G.; Kleven, Gale A.] Wake Forest Sch Med, Winston Salem, NC USA. [Baer, Lisa A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467807704 ER PT J AU Ryan, KL Rickards, CA Muniz, GW Moralez, G Convertino, VA AF Ryan, Kathy L. Rickards, Caroline A. Muniz, Gary W. Moralez, Gilbert Convertino, Victor A. TI Interindividual variability in heart rate variability (HRV) and complexity (HRC) measurements SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ryan, Kathy L.; Rickards, Caroline A.; Muniz, Gary W.; Moralez, Gilbert; Convertino, Victor A.] USA, Inst Surg Res, Lab Div, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801207 ER PT J AU Sands, AL Leidy, HJ Hamaker, BR Maguire, P Campbell, WW AF Sands, Amanda L. Leidy, Heather J. Hamaker, Bruce R. Maguire, Paul Campbell, Wayne W. TI Consumption of the slow digesting starch waxy maize leads to blunted and sustained carbohydrate utilization but does not influence energy expenditure or appetite SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Sands, Amanda L.; Leidy, Heather J.; Hamaker, Bruce R.; Campbell, Wayne W.] Purdue Univ, W Lafayette, IN 47907 USA. [Maguire, Paul] USA, Natick Soldier RDECOM, Combat Feeding Directorate, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802828 ER PT J AU Scrimgeour, A Marchitelli, L Whicker, J Young, AJ AF Scrimgeour, Angus Marchitelli, Louis Whicker, Jered Young, Andrew J. TI Phytase supplementation increases food efficiency ratios, performance activity and body composition in rats fed a low zinc diet SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Scrimgeour, Angus; Marchitelli, Louis; Whicker, Jered; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803053 ER PT J AU Staab, JE Muza, SR Beidleman, BA Fulco, CS Staab, JS Jones, JE Reese, ML Cymerman, A AF Staab, Janet E. Muza, S. R. Beidleman, B. A. Fulco, C. S. Staab, J. S. Jones, J. E. Reese, M. L. Cymerman, A. TI Erythropoietin (EPO) and Soluble Transferrin Receptor (sTfR) Responses at 4300 m Before and After Normobaric Intermittent Hypoxic Exposure SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Staab, Janet E.; Muza, S. R.; Beidleman, B. A.; Fulco, C. S.; Jones, J. E.; Reese, M. L.; Cymerman, A.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Staab, J. S.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803080 ER PT J AU Tharion, WJ Buller, MJ Karis, AJ Mullen, SP AF Tharion, William J. Buller, Mark J. Karis, Anthony J. Mullen, Stephen P. TI Reliability and validity of a wearable heart rate and respiratory rate sensor system SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tharion, William J.; Buller, Mark J.; Karis, Anthony J.; Mullen, Stephen P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803116 ER PT J AU Urso, ML Szelenyi, ER Walters, TJ AF Urso, Maria Laina Szelenyi, Eric R. Walters, Thomas J. TI Metallothionein (MT) expression increases in skeletal muscle following tourniquet-induced ischemia/reperfusion (I/R) injury SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Urso, Maria Laina; Szelenyi, Eric R.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Walters, Thomas J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467800327 ER PT J AU Walters, TJ Ritenour, AE Roe, JL Dubick, MA Christy, RJ Baer, DG AF Walters, Thomas John Ritenour, Amber E. Roe, Janet L. Dubick, Michael A. Christy, Robert J. Baer, David G. TI Effect of Hypobaric Environment on Acute Skeletal Muscle Edema after Ischemia-Reperfusion Injury in Rats SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Walters, Thomas John; Ritenour, Amber E.; Roe, Janet L.; Dubick, Michael A.; Christy, Robert J.; Baer, David G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467802243 ER PT J AU Ward, JA Cancio, LC Batchinsky, AI Newman, PR Convertino, VA Holcomb, JB AF Ward, John A. Cancio, Lee C. Batchinsky, Andriy I. Newman, Paul R. Convertino, Victor A. Holcomb, John B. TI Hemorrhagic Shock Data Mining Project: Poincare Plot Analysis SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ward, John A.; Newman, Paul R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Cancio, Lee C.; Batchinsky, Andriy I.; Convertino, Victor A.; Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467803778 ER PT J AU Whiteman, SA Stapleton, S Jett, M Medis, C AF Whiteman, Sarah Ann Stapleton, Suzanne Jett, Marti Medis, Chanaka TI Evaluating Multiple Signaling Activities in LPS Induced Human PBMCs SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Whiteman, Sarah Ann; Stapleton, Suzanne; Medis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA. [Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2008 VL 22 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V25GZ UT WOS:000208467801758 ER PT J AU Levens, ED Stegmann, BJ Feinberg, EC Larsen, FW AF Levens, Eric D. Stegmann, Barbara J. Feinberg, Eve C. Larsen, Frederick W. TI Ultrasonographic characteristics of the endometrium among patients with fibroids undergoing ART SO FERTILITY AND STERILITY LA English DT Editorial Material ID IN-VITRO FERTILIZATION; EMBRYO-TRANSFER; ASSISTED REPRODUCTION; UTERINE FIBROIDS; THICKNESS; IMPLANTATION; GONADOTROPIN; RECEPTIVITY; LEIOMYOMATA; MYOMECTOMY AB A retrospective cohort study examining all completed nondonor first ART cycles was performed to evaluate the ultrasonographic appearance of the endometrial pattern and thickness at time of hCG administration among precycle screened patients with uterine fibroids compared with patients without fibroids. There was no difference in the endometrial thickness (10.3 +/- 2.0 mm vs. 10.0 +/- 2.6 mm) between those with fibroids and controls; however, the rate of nonproliferative endometrial pattern (3.1% vs. 1.0%) and live birth rates (34.4% vs. 43.0%) were significantly different, most notably among those patients with intramural fibroids. (Fertil Steril (R) 2008; 89:1005-7. (c) 2008 by American Society for Reproductive Medicine.) C1 [Levens, Eric D.; Stegmann, Barbara J.; Feinberg, Eve C.] NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. [Levens, Eric D.; Stegmann, Barbara J.; Feinberg, Eve C.; Larsen, Frederick W.] Walter Reed Army Med Ctr, ART Program, Washington, DC 20307 USA. [Levens, Eric D.; Stegmann, Barbara J.; Feinberg, Eve C.; Larsen, Frederick W.] Walter Reed Army Med Ctr, Natl Naval Med Ctr, Washington, DC 20307 USA. [Levens, Eric D.; Stegmann, Barbara J.; Feinberg, Eve C.; Larsen, Frederick W.] Uniformed Serv Univ Hlth Sci, Washington, DC USA. RP Levens, ED (reprint author), NICHHD, Reprod Biol & Med Branch, NIH, Bldg 10,CRC,Room E1-3140,10 Ctr Dr, Bethesda, MD 20892 USA. EM levense@mail.nih.gov FU Intramural NIH HHS [Z99 HD999999] NR 20 TC 4 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD APR PY 2008 VL 89 IS 4 BP 1005 EP 1007 DI 10.1016/j.fertnstert.2007.03.096 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 292EU UT WOS:000255250100039 PM 17662279 ER PT J AU Feinberg, E Larsen, F Wah, R Alvero, R Armstrong, A AF Feinberg, Eve Larsen, Frederick Wah, Robert Alvero, Ruben Armstrong, Alicia TI The utilization of assisted reproductive technology - Reply SO FERTILITY AND STERILITY LA English DT Letter ID INFERTILITY C1 [Feinberg, Eve; Armstrong, Alicia] NICHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. [Feinberg, Eve; Larsen, Frederick; Wah, Robert; Armstrong, Alicia] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Feinberg, Eve; Larsen, Frederick; Wah, Robert; Armstrong, Alicia] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Alvero, Ruben] Univ Colorado, Hlth Sci Ctr, Aurora, CO USA. RP Feinberg, E (reprint author), NICHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD APR PY 2008 VL 89 IS 4 BP 1026 EP 1027 DI 10.1016/j.fertnstert.2008.02.107 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 292EU UT WOS:000255250100048 ER PT J AU Best, EPH Teeter, AM Landwehr, KJ James, WF Nair, SK AF Best, Elly P. H. Teeter, Allen M. Landwehr, Kevin J. James, William F. Nair, Shyam K. TI Restoration options for potential persistence of submersed aquatic vegetation: combining ecological, hydrodynamic and sediment transport modelling SO FRESHWATER BIOLOGY LA English DT Article DE modelling; persistence; Potamogeton; restoration; Vallisneria ID UPPER MISSISSIPPI-RIVER; VALLISNERIA-AMERICANA; GROWTH; MACROPHYTES; LAKE; PLANT AB 1. Restoration of shallow turbid lakes to promote growth of submersed aquatic vegetation (SAV) requires knowledge of the environmental factors affecting SAV growth and persistence, and a means to predict the success of SAV reestablishment under different management scenarios to improve these environmental conditions. We used a dynamic ecological modelling approach relating SAV responses to changes in physical and chemical conditions, with information on water level, flow and transparency being provided by hydrodynamic and sediment transport models. 2. The potential persistence of Vallisneria americana was similar under simulated environmental conditions in 1946 and in 1954, as was the potential persistence of Potamogeton pectinatus, indicating that the disappearance of V. americana from Peoria Lake (U.S.A.) previously attributed to an extended spring flood in 1954, may have been related to the combined effects of changes in water level, flow and water transparency as well as possibly other factors. 3. Recent environmental conditions (for 2000) proved not to be conducive for the colonization and persistence potential of V. americana, but would allow colonization by P. pectinatus. The construction of a hypothetical levee along the eastern descending line of the navigation channel in Upper Peoria Lake, which was expected to reduce fetch- and navigation-related turbidity, did not improve the situation for V. americana and overall deteriorated the situation for P. pectinatus. Thus, such a hydraulic alteration, generally considered as beneficial for SAV restoration, may not always be successful. 4. The results of the simulations indicated that the environmental conditions for potential persistence in Peoria Lake were generally less favourable for V. americana than for P. pectinatus. Measures suggested to restore SAV communities in such a lake should aim at reducing concentrations of total suspended solids at the point of inflow by a factor of three to four and limiting fetch- and navigation-related resuspension. C1 [Best, Elly P. H.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Teeter, Allen M.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. [Landwehr, Kevin J.] USA, Corps Engineers, Rock Isl, IL USA. [James, William F.] USA, Ctr Res & Dev, Eau Galle Aquat Ecol Lab, Spring Valley, WI USA. [Nair, Shyam K.] E2 Consulting Engineers Inc, Maryville, MO USA. RP Best, EPH (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM elly.p.best@erdc.usace.army.mil NR 35 TC 7 Z9 8 U1 5 U2 21 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0046-5070 J9 FRESHWATER BIOL JI Freshw. Biol. PD APR PY 2008 VL 53 IS 4 BP 814 EP 826 DI 10.1111/j.1365-2427.2007.01932.x PG 13 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA 272UW UT WOS:000253886900012 ER PT J AU MacDonald, JA Tran, PK AF MacDonald, Justin A. Tran, Phuong K. TI The effect of head-related transfer function measurement methodology on localization performance in spatial audio interfaces SO HUMAN FACTORS LA English DT Article ID VISUAL-SEARCH PERFORMANCE; SPEECH; SOUND; HEADPHONE; INTELLIGIBILITY; LISTENERS; DISPLAYS AB Objective: Four head-related transfer function (HRTF) data sets were compared to determine the effect of HRTF measurement methodology on the localization of spatialized auditory stimuli. Background: Spatial audio interfaces typically require HRTF data sets to generate the spatialized auditory stimuli. HRTF measurement is accomplished using a variety of techniques that can require several nearly arbitrary decisions about methodology. The effects of these choices upon the resulting spatial audio interface are unclear. Method: Sixteen participants completed a sound localization task that included real-world, broadband stimuli spatialized at eight locations on the horizontal plane. Four different HRTF data sets were utilized to spatialize the stimuli: two publicly available HRTF data sets and two data sets obtained using different in-house measurement systems. All HRTFs; were obtained from the Knowles Electronics Mannequin for Acoustics Research. Results: Unsigned localization error and proportion of front/back reversals did not differ significantly across HRTF data sets. Poorest accuracy was observed in locations near the medial (front/back) axis of the listener, mainly because of the relatively large proportions of reversals at these locations. Conclusion: This study suggests that the particular generalized HRTF data set chosen for spatialization is of minimal importance to the localizability of the resulting stimuli. Application: This result will inform the design of many spatial audio interfaces that are based upon generalized HRTFs, including wayfaring devices, communication systems, and virtual reality systems. C1 [MacDonald, Justin A.] New Mexico State Univ, Las Cruces, NM 88003 USA. [Tran, Phuong K.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP MacDonald, JA (reprint author), New Mexico State Univ, POB 30001 MSC 3452, Las Cruces, NM 88003 USA. EM jmacd@nmsu.edu NR 34 TC 1 Z9 1 U1 2 U2 3 PU HUMAN FACTORS SOC PI SANTA MONICA PA BOX 1369, SANTA MONICA, CA 90406 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD APR PY 2008 VL 50 IS 2 BP 256 EP 263 DI 10.1518/001872008X250700 PG 8 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 295KC UT WOS:000255472400007 PM 18516836 ER PT J AU Mitchell, KB Gugerty, L Muth, E AF Mitchell, K. Blake Gugerty, Leo Muth, Eric TI Effects of brief training on use of automated external defibrillators by people without medical expertise SO HUMAN FACTORS LA English DT Article ID ACQUISITION; ELECTRODES; SKILL AB Objective: This study examined the effect of three types of brief training on the use of automatic external defibrillators (AEDs) by 43 lay users. Background: Because AEDs were recently approved for home use, brief training for nonprofessional users needs investigation. Method: During training, the exposure training group read an article about AEDs that provided no information on how to operate them; the low-training group inspected the AED and read the operating instructions in the paper-based manual but was not allowed to use the device; and the high-training group watched a training video and performed a mock resuscitation using the AED but no manikin. All participants returned 2 weeks later and performed a surprise simulated AED resuscitation on a manikin. Results: Most participants in each training group met criteria of minimally acceptable performance during the simulated manikin resuscitation, as measured by time to first shock, pad placement accuracy, and safety check performance. All participants who committed errors were able to successfully recover from them to complete the resuscitation. Compared with exposure training, the low and high training had a beneficial effect on time to first shock and errors. Conclusion: Untrained users were able to adequately use this AED, demonstrating walk-up-and-use usability, but additional brief training improved user performance. Application: This study demonstrated the importance of providing high-quality but brief training for home AED users. In conjunction with other findings, the current study helps demonstrate the need for well-designed training for consumer medical devices. C1 [Gugerty, Leo] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. [Mitchell, K. Blake] USA, Natick Soldier Res, Dev & Engn Ctr, Natick, MA 01760 USA. RP Gugerty, L (reprint author), Clemson Univ, Dept Psychol, 418 Brackett Hall, Clemson, SC 29634 USA. EM gugerty@clemson.edu NR 16 TC 16 Z9 16 U1 1 U2 5 PU HUMAN FACTORS SOC PI SANTA MONICA PA BOX 1369, SANTA MONICA, CA 90406 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD APR PY 2008 VL 50 IS 2 BP 301 EP 310 DI 10.1518/001872008X250746 PG 10 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 295KC UT WOS:000255472400011 PM 18516840 ER PT J AU Kaplan, LM Bar-Shalom, Y Blair, WD AF Kaplan, Lance M. Bar-Shalom, Yaakov Blair, William D. TI Assignment costs for multiple sensor track-to-track association SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID FUSION; ALGORITHM AB Successful track-to-track data association in a multisensor, multitarget scenario is predicated on a proper cost function. The cost function for associating two tracks is well established. This paper investigates different versions of the likelihood that more than two tracks represent the same target. These likelihoods lead to different cost functions for the general track-to-track association problem. Two of the likelihoods are approximations based on ad-hoc extensions of the well-known two-track expression. The next approximation is the generalized likelihood (GL), where the true state is replaced by the maximum likelihood (ML) estimate of the target state in the true likelihood. The final likelihood is derived exactly from a diffuse prior of the target state and is referred to as the diffuse prior likelihood (DPL). This paper reveals the connection between the DPL and GL. The last two likelihood expressions incorporate the cross-track error covariance matrices, which are not readily available in distributed track fusion. Therefore, the paper considers three forms of the DPL or GL: 1) the correlated tracks (CT) form by using the actual cross-covariance matrices, 2) the independent tracks (IT) form by assuming the cross-covariance matrices are zero, and 3) the approximated correlated tracks (ACT) form by approximating the cross-covariance matrices. Simulations compare the performance of all likelihood versions. C1 [Kaplan, Lance M.] USA, Res Lab, AMSRD ARL SE SA, Adelphi, MD 20783 USA. [Bar-Shalom, Yaakov] Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA. [Blair, William D.] Georgia Tech Res Inst, Atlanta, GA 30332 USA. RP Kaplan, LM (reprint author), USA, Res Lab, AMSRD ARL SE SA, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM lkaplan@ieee.org NR 24 TC 31 Z9 41 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD APR PY 2008 VL 44 IS 2 BP 655 EP 677 DI 10.1109/TAES.2008.4560213 PG 23 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 331BE UT WOS:000257986900018 ER PT J AU Ni, ZC Shi, YQ Ansari, N Su, W Sun, QB Lin, X AF Ni, Zhicheng Shi, Yun Q. Ansari, Nirwan Su, Wei Sun, Qibin Lin, Xiao TI Robust lossless image data hiding designed for semi-fragile image authentication SO IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY LA English DT Article DE lossless data hiding; reversible data hiding; robust lossless data hiding; semi-fragile authentication; watermarking AB Recently, among various data hiding techniques, a new subset, lossless data hiding, has received increasing interest. Most of the existing lossless data hiding algorithms are, however, fragile in the sense that the hidden data cannot be extracted out correctly after compression or other incidental alteration has been applied to the stego-image. The only existing semi-fragile (referred to as robust in this paper) lossless data hiding technique, which is robust against high-quality JPEG compression, is based on modulo-256 addition to achieve losslessness. In this paper, we first point out that this technique has suffered from the annoying salt-and-pepper noise caused by using modulo-256 addition to prevent overflow/underflow. We then propose a novel robust lossless data hiding technique, which does not generate salt-and-pepper noise. By identifying a robust statistical quantity based on the patchwork theory and employing it to embed data, differentiating the bit-embedding process based on the pixel group's distribution characteristics, and using error correction codes and permutation scheme, this technique has achieved both losslessness and robustness. It has been successfully applied to many images, thus demonstrating its generality. The experimental results show that the high visual quality of stego-images, the data embedding capacity, and the robustness of the proposed lossless data hiding scheme against compression are acceptable for many applications, including semi-fragile image authentication. Specifically, it has been successfully applied to authenticate losslessly compressed JPEG2000 images, followed by possible transcoding. It is expected that this new robust lossless data hiding algorithm can be readily applied in the medical field, law enforcement, remote sensing and other areas, where the recovery of original images is desired. C1 [Ni, Zhicheng; Shi, Yun Q.] New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. [Su, Wei] USA, Commun Elect RD&E Ctr, Ft Monmouth, NJ 07703 USA. [Sun, Qibin; Lin, Xiao] Inst Infocomm Res, Singapore 119613, Singapore. RP Ni, ZC (reprint author), LSI Inc, Allentown, PA 18109 USA. EM zn2@njit.edu; shi@adm.njit.edu; nirwan.ansari@njit.edu; wei.su@us.army.mil; qibin@i2r.a-star.edu.sg; linxiao@fortemedia.com.cn NR 14 TC 73 Z9 84 U1 4 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1051-8215 J9 IEEE T CIRC SYST VID JI IEEE Trans. Circuits Syst. Video Technol. PD APR PY 2008 VL 18 IS 4 BP 497 EP 509 DI 10.1109/TCSVT.2008.918761 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 324TG UT WOS:000257541700007 ER PT J AU Grzegorczyk, TM Zhang, B Kong, JA Barrowes, BE O'Neill, K AF Grzegorczyk, Tomasz M. Zhang, Beijia Kong, Jin Au Barrowes, Benjamin E. O'Neill, Kevin TI Electromagnetic induction from highly permeable and conductive ellipsoids under arbitrary excitation: Application to the detection of unexploded ordnances SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE electromagnetic induction (EMI); ellipsoids; small penetration approximation (SPA); spheroids; unexploded ordnance (UXO) ID EXTENDED BORN APPROXIMATION; METALLIC OBJECTS; TARGETS; UXO; DISCRIMINATION; CLASSIFICATION; SENSORS AB The secondary field produced by 3-D highly permeable and conductive objects is computed in the electromagnetic induction regime, with the purpose of modeling unexploded ordnances (UXOs) and surrounding clutter. The analytical formulation is based on the ellipsoidal coordinate system that is able to model real 3-D geometries as opposed to bodies of revolutions like within a spheroidal approach. At the frequencies of interest (tens of hertz to hundreds of kilohertz), conduction currents in the soil are negligible, and the fields are computed in the magnetoquasistatic regime based on the Laplace equation. Inside the objects, where the wave equation governs the field distribution, the currents are assumed to have a small penetration depth, allowing for the analytical simplification of the field components, which become decoupled at the surface. This approximation, which is valid across the entire frequency spectrum because of the high permeability and conductivity, avoids the necessity of using ellipsoidal wave functions and results in a considerable saving of computational time. Numerical results favorably compare with numerical and experimental data, which proves the usefulness of our method to model UXOs in clutter-contaminated soils. Finally, the optimization approach used to match our numerical predictions with experimental data demonstrates the possibility of remotely inferring the material properties of objects. C1 [Grzegorczyk, Tomasz M.; Zhang, Beijia; Kong, Jin Au] MIT, Elect Res Lab, Cambridge, MA 02139 USA. [Barrowes, Benjamin E.] USA, Corps Engineers, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [O'Neill, Kevin] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Grzegorczyk, TM (reprint author), MIT, Elect Res Lab, Cambridge, MA 02139 USA. NR 44 TC 14 Z9 14 U1 3 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD APR PY 2008 VL 46 IS 4 BP 1164 EP 1176 DI 10.1109/TGRS.2007.912935 PN 2 PG 13 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 285YL UT WOS:000254812000012 ER PT J AU Tsuboi, T Takeo, S Iriko, H Jin, L Tsuchimochi, M Matsuda, S Han, ET Otsuki, H Kaneko, O Sattabongkot, J Udomsangpetch, R Sawasaki, T Torii, M Endo, Y AF Tsuboi, Takafumi Takeo, Satoru Iriko, Hideyuki Jin, Ling Tsuchimochi, Masateru Matsuda, Shusaku Han, Eun-Taek Otsuki, Hitoshi Kaneko, Osamu Sattabongkot, Jetsumon Udomsangpetch, Rachanee Sawasaki, Tatsuya Torii, Motomi Endo, Yaeta TI Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates SO INFECTION AND IMMUNITY LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; PARASITE PLASMODIUM-FALCIPARUM; CIRCUMSPOROZOITE PROTEIN; ESCHERICHIA-COLI; EXPRESSION; TRANSMISSION; PURIFICATION; PROGRESS; PFS25; IMMUNOGENICITY AB One of the major bottlenecks in malaria research has been the difficulty in recombinant protein expression. Here, we report the application of the wheat germ cell-free system for the successful production of malaria proteins. For proof of principle, the Pfs25, PfCSP, and PfAMA1 proteins were chosen. These genes contain very high A/T sequences and are also difficult to express as recombinant proteins. In our wheat germ cell-free system, native and codon-optimized versions of the Pfs25 genes produced equal amounts of proteins. PfCSP and PfAMA1 genes without any codon optimization were also expressed. The products were soluble, with yields between 50 and 200 mu g/ml of the translation mixture, indicating that the cell-free system can be used to produce malaria proteins without any prior optimization of their biased codon usage. Biochemical and immunocytochemical analyses of antibodies raised in mice against each protein revealed that every antibody retained its high specificity to the parasite protein in question. The development of parasites in mosquitoes fed patient blood carrying Plasmodium falciparum gametocytes and supplemented with our mouse anti-Pfs25 sera was strongly inhibited, indicating that both Pfs25-3D7/WG and Pfs25-TBV/WG retained their immunogenicity. Lastly, we carried out a parallel expression assay of proteins of blood-stage P. falciparum. The PCR products of 124 P. falciparum genes chosen from the available database were used directly in a small-scale format of transcription and translation reactions. Autoradiogram testing revealed the production of 93 proteins. The application of this new cell-free system-based protocol for the discovery of malaria vaccine candidates will be discussed. C1 [Tsuboi, Takafumi; Takeo, Satoru; Tsuchimochi, Masateru; Matsuda, Shusaku; Han, Eun-Taek; Sawasaki, Tatsuya; Endo, Yaeta] Ehime Univ, Cell Free Sci & Technol Ctr, Matsuyama, Ehime 7908577, Japan. [Tsuboi, Takafumi; Iriko, Hideyuki; Jin, Ling] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan. [Otsuki, Hitoshi; Kaneko, Osamu; Torii, Motomi] Ehime Univ, Grad Sch Med, Dept Med Parisitol, Toon, Ehime 7910295, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Udomsangpetch, Rachanee] Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand. RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Ctr, 3 Bunkyo, Matsuyama, Ehime 7908577, Japan. EM tsuboi@ccr.ehime-u.ac.jp NR 35 TC 115 Z9 120 U1 2 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2008 VL 76 IS 4 BP 1702 EP 1708 DI 10.1128/IAI.01539-07 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 284SI UT WOS:000254725700039 PM 18268027 ER PT J AU Rodriguez, A Goudsmit, J Companjen, A Mintardjo, R Gillissen, G Tax, D Sijtsma, J Weverling, GJ Holterman, L Lanar, DE Havenga, MJE Radosevic, K AF Rodriguez, Ariane Goudsmit, Jaap Companjen, Arjen Mintardjo, Ratna Gillissen, Gert Tax, Dennis Sijtsma, Jeroen Weverling, Gerrit Jan Holterman, Lennart Lanar, David E. Havenga, Menzo J. E. Radosevic, Katarina TI Impact of recombinant adenovirus serotype 35 priming versus boosting of a Plasmodium falciparum protein: Characterization of T- and B-Cell responses to liver-stage antigen 1 SO INFECTION AND IMMUNITY LA English DT Article ID LIVER-STAGE ANTIGEN-1; IMMUNODEFICIENCY-VIRUS TYPE-1; REPLICATION-DEFECTIVE ADENOVIRUS; IFN-GAMMA RESPONSES; VACCINE VECTORS; CIRCUMSPOROZOITE PROTEIN; INTERFERON-GAMMA; MALARIA VACCINE; IMMUNE-RESPONSES; IMMUNIZATION STRATEGIES AB Prime-boost vaccination regimens with heterologous antigen delivery systems have indicated that redirection of the immune response is feasible. We showed earlier that T-cell responses to circumsporozoite (CS) protein improved significantly when the protein is primed with recombinant adenovirus serotype 35 coding for CS (rAd35.CS). The current study was designed to answer the question whether such an effect can be extended to liver-stage antigens (LSA) of Plasmodium falciparum such as LSA-1. Studies with mice have demonstrated that the LSA-1 protein induces strong antibody response but a weak T-cell immunity. We first identified T-cell epitopes in LSA-1 by use of intracellular gamma interferon (IFN-gamma) staining and confirmed these epitopes by means of enzyme-linked immunospot assay and pentamer staining. We show that a single immunization with rAd35.LSA-1 induced a strong antigen-specific IFN-T CD8(+) T-cell response but no measurable antibody response. In contrast, vaccinations with the adjuvanted recombinant LSA-1 protein induced remarkably low cellular responses but strong antibody responses. Finally, both priming and boosting of the adjuvanted protein by rAd35 resulted in enhanced T-cell responses without impairing the level of antibody responses induced by the protein immunizations alone. Furthermore, the incorporation of rAd35 in the vaccination schedule led to a skewing of LSA-1specific antibody responses toward a Th1type immune response. Our results show the ability of rAd35 to induce potent T-cell immunity in combination with protein in a prime-boost schedule without impairing the B-cell response. C1 [Rodriguez, Ariane; Goudsmit, Jaap; Companjen, Arjen; Mintardjo, Ratna; Gillissen, Gert; Tax, Dennis; Sijtsma, Jeroen; Weverling, Gerrit Jan; Holterman, Lennart; Havenga, Menzo J. E.; Radosevic, Katarina] Crucell Holland BV, NL-2301 CA Leiden, Netherlands. [Goudsmit, Jaap] Univ Amsterdam, Acad Med Ctr, Ctr Poverty Related Communicable Dis, NL-1105 AZ Amsterdam, Netherlands. [Lanar, David E.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. RP Radosevic, K (reprint author), Crucell Holland BV, Archimedesweg 4-6, NL-2333 CN Leiden, Netherlands. EM Katarina.Radosevic@crucell.com RI Lanar, David/B-3560-2011 NR 61 TC 18 Z9 18 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2008 VL 76 IS 4 BP 1709 EP 1718 DI 10.1128/IAI.01614-07 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 284SI UT WOS:000254725700040 PM 18212075 ER PT J AU Akpogheneta, OJ Duah, NO Tetteh, KKA Dunyo, S Lanar, DE Pinder, M Conway, DJ AF Akpogheneta, Onome J. Duah, Nancy O. Tetteh, Kevin K. A. Dunyo, Samuel Lanar, David E. Pinder, Margaret Conway, David J. TI Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific SO INFECTION AND IMMUNITY LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; SERUM ANTIBODIES; ESCHERICHIA-COLI; EARLY-LIFE; MALARIA; IGG; EXPOSURE; CHILDREN; SUBCLASS; PROTECTION AB Naturally acquired antibody responses provide partial protection from clinical malaria, and blood-stage parasite vaccines under development aim to prime such responses. To investigate the determinants of antibody response longevity, immunoglobulin G (IgG) antibodies to several blood-stage vaccine candidate antigens in the sera of two cohorts of children of up to 6 years of age during the dry seasons of 2003 and 2004 in The Gambia were examined. The first cohort showed that most antibodies were lost within less than 4 months of the first sampling if a persistent infection was not present,, so the study of the second-year cohort involved collecting samples from individuals every 2 weeks over a 3-month period. Antibody responses in the second cohort were also influenced by persistent malaria infection, so analysis focused particularly on children in whom parasites were not detected after the first time point. Antibodies to most antigens declined more slowly in children in the oldest age group (>5 years old) and more rapidly in children in the youngest group (<3 years old). However, antibodies to merozoite surface protein 2 were shorter lived than antibodies to other antigens and were not more persistent in older children. The age-specific and antigen-specific differences were not explained by different IgG subclass response profiles, indicating the probable importance of differential longevities of plasma. cell populations rather than antibody molecules. It is likely that young children mostly have short-lived plasma cells and thus experience rapid declines in antibody levels but that older children have longer-lasting antibody responses that depend on long-lived plasma cells. C1 Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England. [Lanar, David E.] Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. [Akpogheneta, Onome J.; Duah, Nancy O.; Dunyo, Samuel; Pinder, Margaret; Conway, David J.] MRC Labs, Fajara, Gambia. RP Conway, DJ (reprint author), MRC Labs, POB 273, Banjul, Gambia. EM dconway@mrc.gm RI Lanar, David/B-3560-2011; OI Conway, David/0000-0002-8711-3037; Duah, Nancy/0000-0001-8819-1793 FU Medical Research Council [MC_U190074193] NR 35 TC 82 Z9 82 U1 2 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2008 VL 76 IS 4 BP 1748 EP 1755 DI 10.1128/IAI.01333-07 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 284SI UT WOS:000254725700044 PM 18212081 ER PT J AU Rieniets, K Zapor, M AF Rieniets, Kimberly Zapor, Michael TI Emerging mold infections: Hyalohyphomycosis SO INFECTIONS IN MEDICINE LA English DT Article DE fungal infections; Fusarium species; hyalohyphomycosis; Scedosporium species ID OF-THE-LITERATURE; INVASIVE FUNGAL-INFECTIONS; SCEDOSPORIUM-APIOSPERMUM; SCOPULARIOPSIS-BREVICAULIS; AMPHOTERICIN-B; IMMUNOCOMPROMISED PATIENTS; PSEUDALLESCHERIA-BOYDII; HEMATOLOGIC MALIGNANCY; TRANSPLANT RECIPIENT; ACREMONIUM-STRICTUM C1 [Rieniets, Kimberly] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Zapor, Michael] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. RP Rieniets, K (reprint author), Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. NR 41 TC 0 Z9 0 U1 0 U2 1 PU SCP COMMUNICATIONS INC PI NEW YORK PA 134 W 29TH ST, NEW YORK, NY 10001-5304 USA SN 0749-6524 J9 INFECT MED JI Infect. Med. PD APR PY 2008 VL 25 IS 4 BP 186 EP + PG 6 WC Infectious Diseases SC Infectious Diseases GA 289RS UT WOS:000255072200004 ER PT J AU Shea-Donohue, T Thomas, K Cody, MJ Zhao, A DeTolla, LJ Kopydlowski, KM Fukata, M Lira, SA Vogel, SN AF Shea-Donohue, Terez Thomas, Karen Cody, M. Joshua Zhao, Aiping DeTolla, Louis J. Kopydlowski, Karen M. Fukata, Masayuki Lira, Sergio A. Vogel, Stefanie N. TI Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis SO INNATE IMMUNITY LA English DT Article DE CXCL1/KC; dextran sodium sulfate; colitis ID INFLAMMATORY-BOWEL-DISEASE; INNATE IMMUNE-RESPONSE; GENE-EXPRESSION; INTERLEUKIN-10-DEFICIENT MICE; NEUTROPHIL INFILTRATION; CHEMOKINE EXPRESSION; MURINE MODEL; IN-VIVO; CYTOKINE; RECEPTOR AB The role of TLRs and MyD88 in the maintenance of gut integrity in response to dextran sodium sulfate (DSS)-induced colitis was demonstrated recently and led to the conclusion that the innate immune response to luminal commensal flora provides necessary signals that facilitate epithelial repair and permits a return to homeostasis after colonic injury. In this report, we demonstrate that a deficit in a single neutrophil chemokine, CXCL1/KC, also results in a greatly exaggerated response to DSS. Mice with a targeted mutation in the gene that encodes this chemokine responded to 2.5% DSS in their drinking water with significant weight loss, bloody stools, and a complete loss of gut integrity in the proximal and distal colon, accompanied by a predominantly mononuclear infiltrate, with few detectable neutrophils. In contrast, CXCL1/KC-/- and wild-type C57BL/6J mice provided water showed no signs of inflammation and, at this concentration of DSS, wild-type mice showed only minimal histopathology, but significantly more infiltrating neutrophils. This finding implies that neutrophil infiltration induced by CXCL1/KC is an essential component of the intestinal response to inflammatory stimuli as well as the ability of the intestine to restore mucosal barrier integrity. C1 [Thomas, Karen; Cody, M. Joshua; Vogel, Stefanie N.] Univ Maryland, Dept Microbiol & Immunol, Sch Med, Baltimore, MD 21201 USA. [Shea-Donohue, Terez; Zhao, Aiping; DeTolla, Louis J.] Univ Maryland, Dept Med, Sch Med, Baltimore, MD 21201 USA. [Shea-Donohue, Terez; Zhao, Aiping] Univ Maryland, Mucosal Biol Res Ctr, Sch Med, Baltimore, MD 21201 USA. [DeTolla, Louis J.; Vogel, Stefanie N.] Univ Maryland, Program Comparat Med, Sch Med, Dept Pathol, Baltimore, MD 21201 USA. [Kopydlowski, Karen M.] USA, Med Mat Dev Act, Pharmaceut Syst Div, Ft Detrick, MD USA. [Fukata, Masayuki; Lira, Sergio A.] Mt Sinai Sch Med, Inst Immunobiol, New York, NY USA. RP Vogel, SN (reprint author), Univ Maryland, Dept Microbiol & Immunol, Sch Med, 660 W Redwood St,Suite 324, Baltimore, MD 21201 USA. EM svogel@som.umaryland.edu FU NCI NIH HHS [R01 CA161373]; NIAID NIH HHS [R01 AI018797, R01 AI052266, AI-18797, R37 AI018797-25, R56 AI018797, AI-49316, R56 AI052266, R37 AI018797-24, R37 AI018797, R01 AI049316, AI-052266, R01 AI049316-07, R01 AI049316-06A2, R21 AI052266, R37 AI018797-26]; NIDDK NIH HHS [DK-072201, R01 DK067989, P01 DK072201-030002, P01 DK072201] NR 33 TC 53 Z9 55 U1 0 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1753-4259 J9 INNATE IMMUN JI Innate Immun. PD APR PY 2008 VL 14 IS 2 BP 117 EP 124 DI 10.1177/1753425908088724 PG 8 WC Biochemistry & Molecular Biology; Immunology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Immunology; Research & Experimental Medicine; Microbiology GA 313WO UT WOS:000256770900006 PM 18713728 ER PT J AU Warren, CS Cepeda-Benito, A Gleaves, DH Moreno, S Rodriguez, S Fernandez, MC Fingeret, MC Pearson, CA AF Warren, Cortney S. Cepeda-Benito, Antonio Gleaves, David H. Moreno, Silvia Rodriguez, Sonia Fernandez, Mari Carmen Fingeret, Michelle Cororve Pearson, Crystal A. TI English and Spanish versions of the Body Shape Questionnaire: Measurement equivalence across ethnicity and clinical status SO INTERNATIONAL JOURNAL OF EATING DISORDERS LA English DT Article DE Body Shape Questionnaire; body image; eating disorders; cross cultural assessment; cross-linguistic assessment; Spain; Spanish ID TESTING MEASUREMENT INVARIANCE; CONFIRMATORY FACTOR-ANALYSIS; ITEM RESPONSE THEORY; OF-FIT INDEXES; EATING-DISORDERS; IMAGE; WOMEN; VALIDITY; MODELS; DISSATISFACTION AB Objective: We evaluated the psychometric properties and measurement equivalence of various forms of the Body Shape Questionnaire (BSQ) (Cooper et al., Int J Eat Disord, 6, 485-494, 1987) in American and Spanish women with and without an eating disorder diagnosis. Method: Participants included four groups of women: Euro-American (n = 505), Hispanic-American (n = 151), and Spanish (n = 445) females without an eating disorder and Spanish women being treated for an eating disorder (n = 177). Results: Single and multigroup confirmatory factor analyses using maximum likelihood estimation with robust standard errors tested the data for configural and metric invariance. Goodness-of-fit statistics indicated that the original and all alternate forms of the BSQ fit the data well across groups. Most factor loadings were similar across groups. We also developed a 10-item version that appeared to be invariant across groups. Conclusion: Results strongly support configural invariance and offer some support for metric invariance. (c) 2007 by Wiley Periodicals, Inc. C1 [Warren, Cortney S.] Univ Nevada, Dept Psychol, Las Vegas, NV 89154 USA. [Cepeda-Benito, Antonio] Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA. [Gleaves, David H.] Univ Canterbury, Dept Psychol, Christchurch 1, New Zealand. [Moreno, Silvia] Univ Jaen, Dept Psychol, Jaen, Spain. [Rodriguez, Sonia; Fernandez, Mari Carmen] Univ Granada, Dept Personal Assessment & Psychol Treatment, Granada, Spain. [Pearson, Crystal A.] Brooke Army Med Ctr, Dept Behav Med, Ft Sam Houston, TX 78234 USA. [Fingeret, Michelle Cororve] Univ Texas Houston, MD Anderson Canc Ctr, Dept Behav Sci, Houston, TX 77030 USA. RP Warren, CS (reprint author), Univ Nevada, Dept Psychol, Las Vegas, NV 89154 USA. EM cortney.warren@unlv.edu RI Cepeda-Benito, Antonio/D-5552-2009; Warren, Cortney/F-1058-2011; Fernandez, Maria Carmen/H-5469-2011; Cepeda-Benito, Antonio/D-2066-2013; Gleaves, David/E-9544-2013; OI Gleaves, David/0000-0003-0954-5739; Warren, Cortney/0000-0002-5878-3007 NR 53 TC 19 Z9 19 U1 1 U2 12 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0276-3478 J9 INT J EAT DISORDER JI Int. J. Eating Disord. PD APR PY 2008 VL 41 IS 3 BP 265 EP 272 DI 10.1002/eat.20492 PG 8 WC Psychology, Clinical; Nutrition & Dietetics; Psychiatry; Psychology SC Psychology; Nutrition & Dietetics; Psychiatry GA 276AV UT WOS:000254114400010 PM 18076088 ER PT J AU Main, JA Gazonas, GA AF Main, Joseph A. Gazonas, George A. TI Uniaxial crushing of sandwich plates under air blast: Influence of mass distribution SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE sandwich plates; metallic foams; fluid-structure interaction; finite elements; optimization; air blast ID COMPRESSIVE STRENGTH PROPERTIES; CELLULAR MATERIAL; ALUMINUM FOAMS; IMPACT; TRANSMISSION; PROPAGATION; DYNAMICS; SUBJECT; CORES; BEAMS AB Motivated by recent efforts to mitigate blast loading using energy-absorbing materials, this paper uses analytical and computational modeling to investigate the influence of mass distribution on the uniaxial crushing of cellular sandwich plates under air blast loading. In the analytical model, the cellular core is represented using a rigid, perfectly-plastic, locking idealization, as in previous studies, and the front and back faces are modeled as rigid, with pressure loading applied to the front face and the back-face unrestrained. This model is also applicable to the crushing of cellular media in "blast pendulum" experiments. Fluid-structure interaction effects are treated using a recent result that accounts for nonlinear compressibility effects for intense air blasts. Predictions of the analytical model show excellent agreement with explicit finite element computations, and the model is used to investigate the response of the system for all possible distributions of mass between the front and back faces and the cellular core. Increasing the mass fraction in the front face is found to increase the impulse required for complete crushing of the cellular core but also to produce undesirable increases in back-face accelerations. Optimal mass distributions for mitigating shock transmission through the sandwich plate are investigated by maximizing the impulse capacity while limiting the back-face accelerations to a specified level. Published by Elsevier Ltd. C1 [Main, Joseph A.] Natl Inst Stand & Technol, Bldg & Fire Res Lab, Gaithersburg, MD 20899 USA. [Gazonas, George A.] USA, Res Lab, Weapons & Mat Res Directorate ATTN AMSRD ARL WM M, Aberdeen Proving Ground, MD 21005 USA. RP Main, JA (reprint author), Natl Inst Stand & Technol, Bldg & Fire Res Lab, 100 Bur Dr,Stop 8611, Gaithersburg, MD 20899 USA. EM joseph.main@nist.gov; gazonas@arl.army.mil OI Gazonas, George/0000-0002-2715-016X NR 27 TC 27 Z9 30 U1 0 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD APR PY 2008 VL 45 IS 7-8 BP 2297 EP 2321 DI 10.1016/j.ijsolstr.2007.11.019 PG 25 WC Mechanics SC Mechanics GA 281BO UT WOS:000254471500025 ER PT J AU Liu, YB Warner, TT Bowers, JF Carson, LP Chen, F Clough, CA Davis, CA Egeland, CH Halvorson, SF Huck, TW Lachapelle, L Malone, RE Rife, DL Sheu, RS Swerdlin, SP Weingarten, DS AF Liu, Yubao Warner, Thomas T. Bowers, James F. Carson, Laurie P. Chen, Fei Clough, Charles A. Davis, Christopher A. Egeland, Craig H. Halvorson, Scott F. Huck, Terrence W. Lachapelle, Leo Malone, Robert E. Rife, Daran L. Sheu, Rong-Shyang Swerdlin, Scott P. Weingarten, Dean S. TI The operational mesogamma-scale analysis and forecast system of the US Army Test and evaluation command. Part I: Overview of the modeling system, the forecast products, and how the products are used SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article ID 4-DIMENSIONAL DATA ASSIMILATION; SURFACE-HYDROLOGY MODEL; BOUNDARY-LAYER; MESOSCALE MODEL; CONVECTION; WINDS; AREA AB Given the rapid increase in the use of operational mesoscale models to satisfy different specialized needs, it is important for the community to share ideas and solutions for meeting the many associated challenges that encompass science, technology, education, and training. As a contribution toward this objective, this paper begins a series that reports on the characteristics and performance of an operational mesogamma-scale weather analysis and forecasting system that has been developed for use by the U. S. Army Test and Evaluation Command. During the more than five years that this four-dimensional weather system has been in use at seven U. S. Army test ranges, valuable experience has been gained about the production and effective use of high-resolution model products for satisfying a variety of needs. This paper serves as a foundation for the rest of the papers in the series by describing the operational requirements for the system, the data assimilation and forecasting system characteristics, and the forecaster training that is required for the finescale products to be used effectively. C1 [Liu, Yubao; Warner, Thomas T.; Carson, Laurie P.; Chen, Fei; Davis, Christopher A.; Rife, Daran L.; Sheu, Rong-Shyang; Swerdlin, Scott P.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Warner, Thomas T.] Univ Colorado, Dept Atmospher & Ocean Sci, Boulder, CO 80309 USA. [Bowers, James F.; Halvorson, Scott F.] USA, Dugway, UT USA. [Clough, Charles A.] USA, Aberdeen Proving Ground, MD USA. [Egeland, Craig H.] USA, Cold Reg Test Ctr, Ft Greely, AK USA. [Huck, Terrence W.] USA, White Sands Missile Range, NM USA. [Lachapelle, Leo] USA, Redstone Tech Test Ctr, Redstone Arsenal, AL USA. [Malone, Robert E.] USA, Ft Huachuca, AZ USA. [Weingarten, Dean S.] USA, Yuma, AZ USA. RP Liu, YB (reprint author), Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA. EM yliu@ucar.edu RI Chen, Fei/B-1747-2009 NR 33 TC 41 Z9 43 U1 0 U2 2 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 EI 1558-8432 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD APR PY 2008 VL 47 IS 4 BP 1077 EP 1092 DI 10.1175/2007JAMC1653.1 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 302RG UT WOS:000255986400011 ER PT J AU Liu, YB Warner, TT Astling, EG Bowers, JF Davis, CA Halvorson, SF Rife, DL Sheu, RS Swerdlin, SP Xu, M AF Liu, Yubao Warner, Thomas T. Astling, Elford G. Bowers, James F. Davis, Christopher A. Halvorson, Scott F. Rife, Daran L. Sheu, Rong-Shyang Swerdlin, Scott P. Xu, Mei TI The operational mesogamma-scale analysis and forecast system of the US Army Test and evaluation command. Part II: Interrange comparison of the accuracy of model analyses and forecasts SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article ID BOUNDARY-LAYER; MESOSCALE-MODEL; VERIFICATION; DESERT; WINDS AB This study builds upon previous efforts to document the performance of the U. S. Army Test and Evaluation Command's Four-Dimensional Weather Modeling System using conventional metrics. Winds, temperature, and specific humidity were verified for almost 15 000 forecasts at five U. S. Army test ranges using near-surface mesonet data. The primary objective was to use conventional metrics to characterize the degree to which forecast accuracy varies from range to range, within the diurnal cycle, with elapsed forecast time, and among the seasons. It was found that there are large interrange differences in forecast error, with larger errors typically associated with the ranges located near complex orography. Similarly, significant variations in accuracy were noted for different times in the diurnal cycle, but the diurnal dependency varied greatly among the ranges. Factor of 2 differences in accuracy were also found across the seasons. C1 [Liu, Yubao; Warner, Thomas T.; Davis, Christopher A.; Rife, Daran L.; Sheu, Rong-Shyang; Swerdlin, Scott P.; Xu, Mei] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Warner, Thomas T.] Univ Colorado, Dept Atmospher & Ocean Sci, Boulder, CO 80309 USA. [Astling, Elford G.; Bowers, James F.; Halvorson, Scott F.] USA, Dugway, UT USA. RP Liu, YB (reprint author), Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA. EM yliu@ucar.edu NR 13 TC 19 Z9 19 U1 1 U2 1 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD APR PY 2008 VL 47 IS 4 BP 1093 EP 1104 DI 10.1175/2007JAMC1654.1 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 302RG UT WOS:000255986400012 ER PT J AU Sharman, RD Liu, YB Sheu, RS Warner, TT Rife, DL Bowers, JF Clough, CA Ellison, EE AF Sharman, Robert D. Liu, Yubao Sheu, Rong-Shyang Warner, Thomas T. Rife, Daran L. Bowers, James F. Clough, Charles A. Ellison, Edward E. TI The operational mesogamma-scale analysis and forecast system of the US Army Test and evaluation command. Part III: Forecasting with secondary-applications models SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article ID BLAST SOUND-PROPAGATION; RAY-ACOUSTIC INTENSITY; NOISE ASSESSMENT MODEL; MOVING MEDIUM; DATA ASSIMILATION; LEVEL; SIMULATIONS; DISPERSION; TIME AB Output from the Army Test and Evaluation Command's Four-Dimensional Weather System's mesoscale model is used to drive secondary-applications models to produce forecasts of quantities of importance for daily decision making at U. S. Army test ranges. Examples of three specific applications-a sound propagation model, a missile trajectory model, and a transport and diffusion model-are given, along with accuracy assessments using cases in which observational data are available for verification. Ensembles of application model forecasts are used to derive probabilities of exceedance of quantities that can be used to help range test directors to make test go-no-go decisions. The ensembles can be based on multiple meteorological forecast runs or on spatial ensembles derived from different soundings extracted from a single meteorological forecast. In most cases, the accuracies of the secondary-application forecasts are sufficient to meet operational needs at the test ranges. C1 [Sharman, Robert D.; Liu, Yubao; Sheu, Rong-Shyang; Warner, Thomas T.; Rife, Daran L.] Natl Ctr Atmospher Res, RAL, Boulder, CO 80307 USA. [Warner, Thomas T.] Univ Colorado, Dept Atmospher & Ocean Sci, Boulder, CO 80309 USA. [Bowers, James F.] USA, Dugway, UT USA. [Clough, Charles A.] USA, Aberdeen Proving Ground, MD USA. [Ellison, Edward E.] USA, White Sands Missile Range, NM USA. RP Sharman, RD (reprint author), Natl Ctr Atmospher Res, RAL, POB 3000, Boulder, CO 80307 USA. EM sharman@ucar.edu NR 39 TC 8 Z9 8 U1 2 U2 3 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 EI 1558-8432 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD APR PY 2008 VL 47 IS 4 BP 1105 EP 1122 DI 10.1175/2007JAMC1655.1 PG 18 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 302RG UT WOS:000255986400013 ER PT J AU Saxen, TR Mueller, CK Warner, TT Steiner, M Ellison, EE Hatfield, EW Betancourt, TL Dettling, SM Oien, NA AF Saxen, Thomas R. Mueller, Cynthia K. Warner, Thomas T. Steiner, Matthias Ellison, Edward E. Hatfield, Eric W. Betancourt, Terri L. Dettling, Susan M. Oien, Niles A. TI The operational mesogamma-scale analysis and forecast system of the US Army Test and evaluation command. Part IV: The white sands missile range auto-nowcast system SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article ID LAYER CONVERGENCE LINES; THUNDERSTORM INITIATION; NORTHEAST COLORADO; HEATED TERRAIN; WSR-88D; FLORIDA; SUMMER; FLOW; PRECIPITATION; SIGNATURES AB During the summer months at the U. S. Army Test and Evaluation Command's (ATEC) White Sands Missile Range (WSMR), forecasting thunderstorm activity is one of the primary duties of the range forecasters. The safety of personnel working on the range and the protection of expensive test equipment depend critically on the quality of forecasts of thunderstorms and associated hazards, including cloud-to-ground lightning, hail, strong winds, heavy rainfall, flash flooding, and tornadoes. The National Center for Atmospheric Research (NCAR) Auto-Nowcast (ANC) system is one of the key forecast tools in the ATEC Four-Dimensional Weather System (4DWX) at WSMR, where its purpose is to aid WSMR meteorologists in their mission of very short term thunderstorm forecasting. Besides monitoring the weather activity throughout the region and warning personnel of potentially hazardous thunderstorms, forecasters play a key role in assisting with the day-to-day planning of test operations on the range by providing guidance with regard to weather conditions favorable to testing. Moreover, based on climatological information about the local weather conditions, forecasters advise their range customers about scheduling tests at WSMR months in advance. This paper reviews the NCAR ANC system, provides examples of the ANC system's use in thunderstorm forecasting, and describes climatological analyses of WSMR summertime thunderstorm activity relevant for long-range planning of tests. The climatological analysis illustrates that radar-detected convective cells with reflectivity of >= 35 dBZ at WSMR are 1) short lived, with 76% having lifetimes of less than 30 min; 2) small, with 67% occupying areas of less than 25 km(2); 3) slow moving, with 79% exhibiting speeds of less than 4 m s(-1); 4) moderately intense, with 80% showing reflectivities in excess of 40 dBZ; and 5) deep, with 80% of the storms reaching far enough above the freezing level to be capable of generating lightning. C1 [Saxen, Thomas R.; Mueller, Cynthia K.; Warner, Thomas T.; Steiner, Matthias; Betancourt, Terri L.; Dettling, Susan M.; Oien, Niles A.] Natl Ctr Atmospher Res, RAL, Boulder, CO 80307 USA. [Warner, Thomas T.] Univ Colorado, Dept Atmospher & Ocean Sci, Boulder, CO 80309 USA. [Ellison, Edward E.; Hatfield, Eric W.] USA, White Sands Missile Range, NM USA. RP Warner, TT (reprint author), Natl Ctr Atmospher Res, RAL, POB 3000, Boulder, CO 80307 USA. EM warner@ucar.edu RI Steiner, Matthias/K-5013-2013 OI Steiner, Matthias/0000-0002-3973-375X NR 36 TC 10 Z9 10 U1 1 U2 2 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD APR PY 2008 VL 47 IS 4 BP 1123 EP 1139 DI 10.1175/2007JAMC1656.1 PG 17 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 302RG UT WOS:000255986400014 ER PT J AU Burnette, JE Edelstein, AS Fischer, GA Nowak, E Bernard, W Cheng, SF Nordman, C Egelhoff, WF AF Burnette, James E. Edelstein, Alan S. Fischer, G. A. Nowak, E. Bernard, W. Cheng, Shu Fan Nordman, Cathy Egelhoff, W. F., Jr. TI Initial studies on microelectromechanical system flux concentrators SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 52nd Annual Conference on Magnetism and Magnetic Materials CY NOV 05-09, 2007 CL Tampa, FL SP Phys Conf Inc, IEEE, Magnet Soc ID ROOM-TEMPERATURE; MAGNETORESISTANCE AB To take advantage of the potential offered by the recent increase in the magnetoresistance of magnetic tunnel junctions, it is necessary to address the problem of 1/f noise. ARL has been working on a device, the microelectromechanical system (MEMS) flux concentrator, that mitigates this problem by modulating the sensed magnetic field so that the sensor operates at a higher frequency region where the 1/f noise is smaller. Initial results of testing the device are reported. Though the final step in the fabrication of the device appears to have adversely affected the MEMS motion, two important results were obtained. They are (1) applying the large amplitude voltage at kilohertz frequencies necessary to drive the MEMS structure does not increase the background noise and (2) even though the width of the drive voltage is several hertz, one can demodulate the signal using a lock-in amplifier in order to extract 1 Hz modulation signals. This last result shows that the sensor can be used to detect slow moving or varying magnetic anomalies. (C) 2008 American Institute of Physics. C1 [Burnette, James E.; Edelstein, Alan S.; Fischer, G. A.] USA, Res Lab, Adelphi, MD 20783 USA. [Nowak, E.] Univ Delaware, Dept Phys & Astron, Newark, DE 19711 USA. [Bernard, W.] MEMS & Nanotechnol Exchange, Reston, VA 20191 USA. [Cheng, Shu Fan] NRL, Washington, DC 20375 USA. [Nordman, Cathy] NVE, Eden Prairie, NM 55344 USA. [Egelhoff, W. F., Jr.] NIST, Gaithersburg, MD 20899 USA. RP Edelstein, AS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM edelstein@arl.army.mil NR 7 TC 3 Z9 3 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 1 PY 2008 VL 103 IS 7 AR 07E930 DI 10.1063/1.2838480 PG 3 WC Physics, Applied SC Physics GA 289GO UT WOS:000255043200667 ER PT J AU Long, J McHenry, M Urciuoli, DP Keylin, V Huth, J Salem, TE AF Long, Jianguo McHenry, Mike Urciuoli, Damian P. Keylin, Vladimir Huth, Joe Salem, Thomas E. TI Nanocrystalline material development for high-power inductors SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 52nd Annual Conference on Magnetism and Magnetic Materials CY NOV 05-09, 2007 CL Tampa, FL SP Phys Conf Inc, IEEE, Magnet Soc ID ULTRAFINE GRAIN-STRUCTURE; MAGNETIC-PROPERTIES; ALLOYS AB A new high-saturation induction, high-temperature nanocomposite alloy for high-power inductors is discussed. This material has FeCo with an A2 or B2 structure embedded in an amorphous matrix. An alloy of composition Fe56Co24Nb4B13Si2Cu1 was cast into a 1.10 in. wide, 0.001 in. thick ribbon from which a toroidal core of approximately 4.25 in. outer diameter, 1.38 in. inner diameter, and 1.10 in. tall was wound. The core was given a 2 T transverse magnetic field anneal, and impregnated for strength. Field annealing resulted in a linear B-H response with a relative permeability of 1400 that remained constant up to field strengths of 1.2 T. The core was used to construct a 25 mu H inductor for a 25 kW dc-dc converter. The inductor was rated for operation in discontinuous conduction mode at a peak current of 300 A and a switching frequency of up to 20 kHz. Compared to commercially available materials, this new alloy can operate at higher flux densities and higher temperatures, thus reducing the overall size of the inductor. (C) 2008 American Institute of Physics. C1 [Long, Jianguo; McHenry, Mike] Carnegie Mellon Univ, Dept Mat Sci & Engn, Pittsburgh, PA 15213 USA. [Urciuoli, Damian P.] USA, Sensors & Elect Device Direcotrate, Res Lab, Adelphi, MD 20783 USA. [Keylin, Vladimir; Huth, Joe] Div Spang & Co, Magnet Technol Ctr, Pittsburgh, PA 15213 USA. [Salem, Thomas E.] USN Acad, Dept Elect Engn, Annapolis, MD 21402 USA. RP Long, J (reprint author), Carnegie Mellon Univ, Dept Mat Sci & Engn, Pittsburgh, PA 15213 USA. EM durciuoli@arl.army.mil RI McHenry, Michael/B-8936-2009; Long, Jianguo/F-7180-2011 NR 9 TC 25 Z9 25 U1 1 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD APR 1 PY 2008 VL 103 IS 7 AR 07E705 DI 10.1063/1.2829033 PG 3 WC Physics, Applied SC Physics GA 289GO UT WOS:000255043200598 ER PT J AU Schell, MA Lipscomb, L DeShazer, D AF Schell, Mark A. Lipscomb, Lyla DeShazer, David TI Comparative genomics and an insect model rapidly identify novel virulence genes of Burkholderia mallei SO JOURNAL OF BACTERIOLOGY LA English DT Article ID NEMATODE CAENORHABDITIS-ELEGANS; III SECRETION SYSTEM; SUBTRACTIVE HYBRIDIZATION; PSEUDOMONAS-PSEUDOMALLEI; IN-VIVO; MOLECULAR CHARACTERIZATION; BIOLOGICAL WARFARE; PROTEIN SECRETION; SP-NOV; IDENTIFICATION AB Burkholderia pseudomallei and its host-adapted deletion clone Burkholderia mallei cause the potentially fatal human diseases melioidosis and glanders, respectively. The antibiotic resistance profile and ability to infect via aerosol of these organisms and the absence of protective vaccines have led to their classification as major biothreats and select agents. Although documented infections by these bacteria date back over 100 years, relatively little is known about their virulence and pathogenicity mechanisms. We used in silico genomic subtraction to generate their virulome, a set of 650 putative virulence-related genes shared by B. pseudomallei and B. mallei but not present in five closely related nonpathogenic Burkholderia species. Although most of these genes are clustered in putative operons, the number of targets for mutant construction and verification of reduced virulence in animal models is formidable. Therefore, Galleria mellonella (wax moth) larvae were evaluated as a surrogate host; we found that B. pseudomallei and B. mallei, but not other phylogenetically related bacteria, were highly pathogenic for this insect. More importantly, four previously characterized B. mallei mutants with reduced virulence in hamsters or mice had similarly reduced virulence in G. mellonella larvae. Site-specific inactivation of selected genes in the computationally derived virulome identified three new potential virulence genes, each of which was required for rapid and efficient killing of larvae. Thus, this approach may provide a means to quickly identify high-probability virulence genes in B. pseudomallei, B. mallei, and other pathogens. C1 [Schell, Mark A.; Lipscomb, Lyla] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA. [DeShazer, David] USA, Med Res Inst Infect Dis, Bacterial Div, Frederick, MD 21702 USA. RP Schell, MA (reprint author), Univ Georgia, Dept Microbiol, Athens, GA 30602 USA. EM schell@uga.edu FU NIAID NIH HHS [R21 AI069081]; PHS HHS [R21-AAI69081] NR 70 TC 45 Z9 45 U1 1 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD APR PY 2008 VL 190 IS 7 BP 2306 EP 2313 DI 10.1128/JB.01735-07 PG 8 WC Microbiology SC Microbiology GA 278YX UT WOS:000254323300008 PM 18223084 ER PT J AU Maskery, SM Hu, H Hooke, J Shriver, CD Liebman, MN AF Maskery, Susan M. Hu, Hai Hooke, Jeffrey Shriver, Craig D. Liebman, Michael N. TI A Bayesian derived network of breast pathology co-occurrence SO JOURNAL OF BIOMEDICAL INFORMATICS LA English DT Article DE Bayesian analysis; histopathology; breast neoplasms; breast diseases ID CANCER RISK; DISEASE; LESIONS; CLASSIFICATION; SYSTEM; WOMEN AB In this paper, we present the validation and verification of a machine-learning based Bayesian network of breast pathology co-occurrence. The present/not present occurrences of 29 common breast pathologies from 1631 pathology reports were used to build the network. All pathology reports were developed by a single pathologist. The resulting network has 25 diagnosis nodes interconnected by 40 arcs. Each arc represents a predicted co-occurrence or null co-occurrence. Model verification involved assessing the robustness of the original network structure after random exclusion of 25%, 50%, and 75% of the pathology report dataset. The structure of the network appears stable as random removal of 75% of the records in the original dataset leaves 81% of the original network intact. Model validation was primarily assessed by review of the breast pathology literature for each arc in the network. Almost all network identified co-occurrences (95%) have been published in the breast pathology literature or were verified by expert opinion. In conclusion, the Bayesian network of breast pathology co-occurrence presented here is both robust with respect to incomplete data and validated by consistency with the breast pathology literature and by expert opinion. Further, the ability to utilize a specific pathology observation to predict multiple co-current pathologies enables exploration of pathology co-occurrence patterns in an intuitive manner that may have broader application in both the breast pathologist clinical community and the breast cancer research community. (c) 2008 Elsevier Inc. All rights reserved. C1 [Maskery, Susan M.; Hu, Hai; Liebman, Michael N.] Windber Res Inst, Windber, PA 15963 USA. [Hooke, Jeffrey; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Gen Surg Serv, Washington, DC 20307 USA. RP Maskery, SM (reprint author), Windber Res Inst, 620 7th St, Windber, PA 15963 USA. EM s.maskery@wriwindber.org NR 26 TC 15 Z9 16 U1 1 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1532-0464 J9 J BIOMED INFORM JI J. Biomed. Inform. PD APR PY 2008 VL 41 IS 2 BP 242 EP 250 DI 10.1016/j.jbi.2007.12.005 PG 9 WC Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA 293UE UT WOS:000255360000004 PM 18262472 ER PT J AU Curtin, BF Seetharam, KI Dhoieam, P Gordon, RK Doctor, BP Nambiar, MP AF Curtin, Bryan F. Seetharam, Karthik I. Dhoieam, Pilin Gordon, Richard K. Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Resveratrol induces catalytic bioscavenger paraoxonase 1 expression and protects against chemical warfare nerve agent toxicity in human cell lines SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE nerve agents; organophosphates; transcriptional inducers; paraoxonase gene expression; neuroprotection ID HUMAN SERUM PARAOXONASE; NEUROPATHY TARGET ESTERASE; ORGANOPHOSPHATE TOXICITY; PON1 STATUS; ACETYLCHOLINESTERASE; ARYLESTERASE; SOMAN; CHLORPYRIFOS; ENZYME; MICE AB Current advances in enzyme bioscavenger prophylactic therapy against chemical warfare nerve agent (CWNA) exposure are moving towards the identification of catalytic bioscavengers that can degrade large doses of organophosphate (OP) nerve agents without self destruction. This is a preferred method compared to therapy with the purified stoichiometric bioscavenger, butyrylcholinesterase, which binds OPs 1:1 and would thus require larger doses for treatment. Paraoxonase-1 (PON-1) is one such catalytic bioscavenger that has been shown to hydrolyze OP insecticides and contribute to detoxification in animals and humans. Here we investigated the effects of a common red wine ingredient, Resveratrol (RSV), to induce the expression of PON-1 in the human hepatic cell line HC04 and evaluated the protection against CWNA simulants. Dose-response curves showed that a concentration of 20 mu M RSV was optimal in inducing PON-1 expression in HC04 cells. RSV at 20 mu M increased the extracellular PON-1 activity approximately 150% without significantly affecting the cells. Higher doses of RSV were cytotoxic to the cells. Resveratrol also induced PON-1 in the human lung cell line A549. RSV pre-treatment significantly (P= 0.05) protected the hepatic cells against exposure to 2 x LD50 of soman and sarin simulants. However, lung cells were protected against soman simulant exposure but not against sarin simulant exposure following RSV treatment. In conclusion, these studies indicate that dietary inducers, such as RSV, can up-regulate PON-1, a catalytic bioscavenger, which can then hydrolyze and protect against CWNA-induced toxicity, providing a prospective new method to protect against CWNA exposure. C1 [Curtin, Bryan F.; Seetharam, Karthik I.; Dhoieam, Pilin; Gordon, Richard K.; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. [Nambiar, Madhusoodana P.] USUHS, Dept Med, Bethesda, MD USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. EM Madhusoodana.nambiar@na.amedd.army.mil NR 45 TC 19 Z9 20 U1 1 U2 5 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD APR 1 PY 2008 VL 103 IS 5 BP 1524 EP 1535 DI 10.1002/jcb.21543 PG 12 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 285HP UT WOS:000254768200017 PM 17879943 ER PT J AU Tribble, DR Baqar, S Pang, LW Mason, C Houng, HSH Pitarangsi, C Lebron, C Armstrong, A Sethabutr, O Sanders, JW AF Tribble, David R. Baqar, Shahida Pang, Lorrin W. Mason, Carl Houng, Huo-Shu H. Pitarangsi, Chittima Lebron, Carlos Armstrong, Adam Sethabutr, Orntipa Sanders, John W. TI Diagnostic approach to acute diarrheal illness in a military population on training exercises in Thailand, a region of Campylobacter hyperendemicity SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID POLYMERASE-CHAIN-REACTION; ENTEROINVASIVE ESCHERICHIA-COLI; ACUTE INFECTIOUS DIARRHEA; HUMAN STOOL SPECIMENS; TRAVELERS DIARRHEA; FECAL LACTOFERRIN; INVASIVE DIARRHEA; MICROPLATE ASSAY; RAPID DETECTION; JEJUNI AB High rates of Campylobacter fluoroquinolone resistance highlight the need to evaluate diagnostic strategies that can be used to assist with clinical management. Diagnostic tests were evaluated with U.S. soldiers presenting with acute diarrhea during deployment in Thailand. The results of bedside and field laboratory diagnostic tests were compared to stool microbiology findings for 182 enrolled patients. Campylobacter jejuni was isolated from 62% of the cases. Clinical and laboratory findings at the time of presentation were evaluated to determine their impact on the posttest probability, defined as the likelihood of a diagnosis of Campylobacter infection. Clinical findings, the results of tests for inflammation (stool occult blood testing [Hemoccult], fecal leukocytes, fecal lactoferrin, plasma C-reactive protein), and the numbers of Campylobacter-specific antibody-secreting cells in peripheral blood failed to increase the posttest probability above 90% in this setting of Campylobacter hyperendemicity when these findings were present. Positive results by a Campylobacter-specific commercial enzyme immunoassay (EIA) and, less so, a research PCR were strong positive predictors. The negative predictive value for ruling out Campylobacter infection, defined as a posttest probability of less than 10%, was similarly observed with these Campylobacter-specific stool-based tests as well the fecal leukocyte test. Compared to the other tests evaluated, the Campylobacter EIA is a sensitive and specific rapid diagnostic test that may assist with diagnostic evaluation, with consideration of the epidemiological setting, logistics, and cost. C1 [Tribble, David R.; Baqar, Shahida] Naval Med Res Ctr, Enter Dis Dept, Silver Spring, MD USA. [Pang, Lorrin W.; Mason, Carl; Pitarangsi, Chittima; Sethabutr, Orntipa] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Houng, Huo-Shu H.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Lebron, Carlos] Naval Environm Prevent Med Unit 6, Honolulu, HI USA. [Armstrong, Adam; Sanders, John W.] Natl Naval Med Ctr, Bethesda, MD USA. RP Tribble, DR (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM dtribble@usuhs.mil OI MASON, CARL/0000-0002-3676-2811 NR 43 TC 12 Z9 12 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2008 VL 46 IS 4 BP 1418 EP 1425 DI 10.1128/JCM.02168-07 PG 8 WC Microbiology SC Microbiology GA 286SN UT WOS:000254866400039 PM 18234869 ER PT J AU Winter, WE Maxwell, GL Tian, CQ AF Winter, William E., III Maxwell, G. Larry Tian, Chunqiao TI Prognostic role of CA-125 nadir in stage IV epithelial ovarian cancer - In reply SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Letter C1 [Winter, William E., III] NW Canc Specialists, Div Gynecol Oncol, Portland, OR USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. [Tian, Chunqiao] Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA. RP Winter, WE (reprint author), NW Canc Specialists, Div Gynecol Oncol, Portland, OR USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD APR 1 PY 2008 VL 26 IS 10 BP 1772 EP 1772 DI 10.1200/JCO.2007.15.8204 PG 1 WC Oncology SC Oncology GA 281WY UT WOS:000254530800040 ER PT J AU Bliese, PD Wright, KM Adler, AB Cabrera, O Castro, CA Hoge, CW AF Bliese, Paul D. Wright, Kathleen M. Adler, Amy B. Cabrera, Oscar Castro, Carl A. Hoge, Charles W. TI Validating the primary care posttraumatic stress disorder screen and the posttraumatic stress disorder checklist with soldiers returning from combat SO JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY LA English DT Article DE posttraumatic stress disorder; validation; assessment; military ID PTSD CHECKLIST; PSYCHOMETRIC PROPERTIES; FEMALE VETERANS; DSM-IV; INSTRUMENT; DIAGNOSIS; VIETNAM; UTILITY; VERSION; CANCER AB The purpose of the research was to assess the diagnostic efficiency of the Primary Care Posttraumatic Stress Disorder Screen (PC-PTSD) and the Posttraumatic Stress Disorder Checklist (PCL) as clinical screening tools for active duty soldiers recently returned from a combat deployment. A secondary goal was to examine the item-level characteristics of both the PC-PTSD and the PCL. A validation study conducted with a sample of 352 service members showed that both the PC-PTSD and PCL had good diagnostic efficiency. The overall diagnostic efficiency assessed by the area under the curve (AUC) was virtually the same for both the PC-PTSD and PCL. The most efficient cutoff values for the PC-PTSD were either 2 or 3 "yes" responses with the latter favoring specificity. For the PCL, the most efficient cutoff values were between 30 and 34, mirroring recommended PCL cutoff values from some studies in primary care settings. The examination of item characteristics suggested a 4-item PCL with an AUC virtually identical to that of the full PCL. Item analyses also identified that the most discriminate item in both scales pertained to symptoms of avoidance. Implications and limitations are discussed. C1 [Bliese, Paul D.; Wright, Kathleen M.; Adler, Amy B.; Cabrera, Oscar] USA, Med Res Unit, Heidelberg, Germany. [Bliese, Paul D.; Castro, Carl A.; Hoge, Charles W.] Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD 20910 USA. RP Bliese, PD (reprint author), Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD 20910 USA. EM paul.bliese@us.army.mil NR 37 TC 345 Z9 345 U1 5 U2 23 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0022-006X J9 J CONSULT CLIN PSYCH JI J. Consult. Clin. Psychol. PD APR PY 2008 VL 76 IS 2 BP 272 EP 281 DI 10.1037/0022-006X.76.2.272 PG 10 WC Psychology, Clinical SC Psychology GA 282AG UT WOS:000254539400009 PM 18377123 ER PT J AU Arnedzake, P Brown, E Hommerich, U Trivedi, SB Zavada, JM AF Arnedzake, P. Brown, E. Hommerich, U. Trivedi, S. B. Zavada, J. M. TI Crystal growth and spectroscopic characterization of Pr-doped KPb2Cl5 for mid-infrared laser applications SO JOURNAL OF CRYSTAL GROWTH LA English DT Article; Proceedings Paper CT 15th International Conference on Crystal Growth CY AUG 12-17, 2007 CL Salt Lake City, UT SP ACCG DE characterization; Bridgman technique; halides; solid-state lasers ID OPTICAL-PROPERTIES; LEAD CHLORIDES; MU-M; CAGA2S4-DY3+; ND3+ AB We report on the purification, crystal growth, and infrared (IR) spectroscopic properties of Pr-doped KPb2Cl5 for applications in mid-IR solid-state lasers. KPb2Cl5 has a narrow phonon spectrum extending to only similar to 200cm(-1), which leads to small non-radiative decay rates and long-wavelength IR emission from trivalent rare earth ions. The synthesis of Pr:KPb2Cl5 was based on the purification of commercial starting materials through baking under a dynamic vacuum, directional solidification, and multi-pass translation in a zone-melting system. The growth of the purified Pr:KPb2Cl5 material was then carried out through vertical Bridgman technique employing a two-zone furnace. Under 1540 nm diode laser excitation, Pr:KPb2Cl5 exhibited a broad mid-IR emission band centered at 4.6 mu m, which was assigned to the H-3(5) -> H-3(4) transition. The emission lifetime was determined to be 2.7 ms at room temperature. Based on Judd-Ofelt analysis, the radiative lifetime was calculated to be 26.9 ms, which results in a mid-IR emission quantum efficiency of similar to 10% and a peak emission cross-section of 4.9 x 10(-21) cm(2). (c) 2007 Elsevier B.V. All rights reserved. C1 [Arnedzake, P.; Brown, E.; Hommerich, U.] Hampton Univ, Dept Phys, Hampton, VA 23668 USA. [Trivedi, S. B.] Brimrose Corp Amer, Baltimore, MD 21152 USA. [Zavada, J. M.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Hommerich, U (reprint author), Hampton Univ, Dept Phys, Hampton, VA 23668 USA. EM uwe.hommerich@hamptonu.edu NR 21 TC 19 Z9 19 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD APR PY 2008 VL 310 IS 7-9 SI SI BP 2015 EP 2019 DI 10.1016/j.jcrysgro.2007.10.042 PG 5 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 300RP UT WOS:000255843200130 ER PT J AU Huang, WL Ressler, EK Shoop, BL AF Huang, Wenli Ressler, Eugene K. Shoop, Barry L. TI Three-dimensional interconnection scheme for color error diffusion SO JOURNAL OF ELECTRONIC IMAGING LA English DT Article ID BLUE-NOISE AB This is a generalization, to color images, of earlier results on two-dimensional monochromatic haffloning with error diffusion neural networks (EDNs). Previously, we have shown that EDNs find local minima of frequency-weighted error between a binary halftone output and corresponding smoothly varying input, which is an ideal framework for solving halftone problems. We cast color halftoning as four related subproblems: the first three are to compute good binary halftones for each primary color and the fourth is to simultaneously minimize frequency-weighted error in the luminosity of the composite result We show that an EDN with a three-dimensional (3D) interconnection scheme can solve all four problems in parallel. The 3D EDN algorithm not only shapes the error to frequencies to which the human visual system (HVS) is least sensitive but also shapes the error in colors to which the HVS is least sensitive-namely it satisfies the minimum brightness variation criterion. The correlation among the color planes by luminosity reduces the formation of high contrast pixels, such as black and white pixels that often constitute color noise, resulting in a smoother and more homogeneous appearance in a halftone image and a closer resemblance to the continuous tone image. (C) 2008 SPIE and /S&T. C1 [Huang, Wenli; Ressler, Eugene K.; Shoop, Barry L.] US Mil Acad, Dept Elect Engn & Comp Sci, Photon Res Ctr, West Point, NY 10996 USA. RP Huang, WL (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, Photon Res Ctr, West Point, NY 10996 USA. EM wenli.huang@usma.edu NR 22 TC 0 Z9 0 U1 1 U2 1 PU I S & T - SOC IMAGING SCIENCE TECHNOLOGY PI SPRINGFIELD PA 7003 KILWORTH LANE, SPRINGFIELD, VA 22151 USA SN 1017-9909 J9 J ELECTRON IMAGING JI J. Electron. Imaging PD APR-JUN PY 2008 VL 17 IS 2 AR 023002 DI 10.1117/1.2907213 PG 12 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA 330JT UT WOS:000257937900003 ER PT J AU Koagel, SO Mines, P Apicella, M Sweet, M AF Koagel, Susan O. Mines, Pete Apicella, Michael Sweet, Mark TI In vitro study to compare the corona microleakage of Tempit UltraF, Tempit, IRM, and cavit by using the fluid transport model SO JOURNAL OF ENDODONTICS LA English DT Article DE cavit; coronal microleakage; fluid transport model; IRM; Tempit; Tempit Ultra-F ID TEMPORARY RESTORATIVE MATERIALS; ENDODONTICALLY TREATED TEETH; SEALING ABILITY; BACTERIAL PENETRATION; IRRIGATING SOLUTIONS; FILLING MATERIALS; LEAKAGE; QUALITY; FAILURE; TERM AB An adequate coronal seal is critical for the success of root canal therapy. The purpose of this study was to assess and compare the coronal microleakage of 4 temporary filling materials used to seal the access cavity in root canal treated teeth. Standardized access cavities were prepared in 55 extracted human, single canal teeth. They were instrumented by using a crown-down method to a size 45 file. The smear layer was removed with a 1-minute soak with 17% ethylenediaminetetraacetic acid followed by a 10-minute soak with 5.25% NaOCl and dried with paper points. All roots were obturated with gutta-percha and AH Plus sealer by using the continuous wave of condensation technique. The teeth were randomly divided into 4 groups of 10 teeth, with the remaining teeth serving as positive and negative controls. The access openings of the teeth in the experimental groups were filled with 4 mm of Cavit, IRM, Tempit, or Tempit-Ultra-F. All teeth were stored in 100% humidity at 37 degrees for 10 days, allowing sealer to set before testing. After thermocycling for 500 cycles (5 degrees C-55 degrees C), microleakage was measured by using the fluid transport model at 10 psi. All materials tested leaked. Kruskal-Wallis and Mann-Whitney U analysis indicated significantly less leakage (P <.05) with Tempit UltraF compared with Cavit and IRM. There were no statistically significant differences between Tempit Ultra-F and Tempit or between Cavit, IRM, and Tempit. C1 [Koagel, Susan O.; Mines, Pete; Apicella, Michael; Sweet, Mark] USA, Ft Bragg, NC USA. RP Koagel, SO (reprint author), 1459 Cheyenne Ridge, El Paso, TX 79912 USA. EM susiekoagel@yahoo.com NR 30 TC 8 Z9 9 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD APR PY 2008 VL 34 IS 4 BP 442 EP 444 DI 10.1016/j.joen.2008.01.009 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 282EV UT WOS:000254551300010 PM 18358892 ER PT J AU Hatch, GW Roberts, S Joyce, AP Runner, R McPherson, JC AF Hatch, Garth W. Roberts, Steven Joyce, Anthony P. Runner, Royce McPherson, James C., III TI Comparative study of the variability of 0.06 tapered rotary endodontic files to current taper standards SO JOURNAL OF ENDODONTICS LA English DT Article DE NiTi rotary files; taper; variability AB This study compared the taper variation among Profile, Guidance, and EndoSequence 0.06 tapered rotary files to current standards. Fifteen files of sizes 35, 40, and 45 from each manufacturer were evaluated for a total of 135 files. A digital image of the first 4 mm of each file was captured with light microscope at 22X, calibrated for 0.001-mm accuracy, and analyzed. The diameter of each file was measured at 1 and 4 mm, and the taper was calculated. Of the 3 file systems, 100% of the Profile files, 97.8% of the Guidance files, and 86.7% of the EndoSequence files fell within +/- 0.02 taper. All file systems demonstrated variability within their groups. A series of chi(2) analyses indicated that manufacturers tend to produce Guidance and Profile tapers slightly under the ideal 0.06 taper (P <.05). The tapers of EndoSequence files were just as likely to be over or under the advertised 0.06 taper (P >.05). C1 [Hatch, Garth W.; Joyce, Anthony P.] USA, Endodont Residency Program, Ft Gordon, GA USA. [Roberts, Steven] Med Coll Georgia, Dept Endodont, Augusta, GA 30912 USA. [Runner, Royce; McPherson, James C., III] USA, Dept Clin Invest, Ft Gordon, GA USA. RP Hatch, GW (reprint author), CMR 405,Box 1926, APO, AE 09034 USA. EM garth.hatch@amedd.army.mil NR 15 TC 1 Z9 1 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD APR PY 2008 VL 34 IS 4 BP 463 EP 465 DI 10.1016/j.joen.2008.01.003 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 282EV UT WOS:000254551300016 PM 18358898 ER PT J AU Trevino, SF Wiegand, DA AF Trevino, S. F. Wiegand, D. A. TI Mechanically induced damage in composite plastic-bonded explosives: A small angle neutron and X-ray study SO JOURNAL OF ENERGETIC MATERIALS LA English DT Article DE binder; coating; composite; damage; deformed; filler; fracture; neutron; particle size; porosity; scattering; X-ray AB The principle ingredient of plastic-bonded explosives, the filler explosive, is usually a crystalline material that releases substantial chemical energy when made to react (burn or detonate). A second material, the binder, which is usually an amorphous substance, is added as a minor constituent, one of whose purposes is to coat the filler in order to prevent frictional heat generation during the application of strain. It is important to know the condition of these materials in the composite as formulated and their response to deformation. Small angle neutron and X-ray scattering is used to determine the specific surface area of the interface between (a) filler and binder and (b) the pores. Two radiations are used in order to obtain sufficient contrast variation for the solution (although not unique) of a three-parameter problem. The results strongly suggest that the binder quite effectively performs the intended role. The results also indicate that in heavily mechanically damaged samples the filler particles are fractured and that most of the new fracture surfaces are coated with binder. C1 [Wiegand, D. A.] ARDEC, Armaments Engn & Technol Ctr, Energet & Warheads Div, Picatinny Arsenal, NJ 07806 USA. [Trevino, S. F.] USA, Res Labs, Weap & Mat Res Directorate, Bethesda, MD USA. [Trevino, S. F.] NIST, NIST Ctr Neutron Res, Gaithersburg, MD 20899 USA. RP Wiegand, DA (reprint author), ARDEC, Armaments Engn & Technol Ctr, Energet & Warheads Div, Bldg 3022, Picatinny Arsenal, NJ 07806 USA. EM donald.wiegand@us.army.mil NR 9 TC 7 Z9 7 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0737-0652 J9 J ENERG MATER JI J. Energ. Mater. PD APR-JUN PY 2008 VL 26 IS 2 BP 79 EP 101 DI 10.1080/07370650701801705 PG 23 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical; Materials Science, Multidisciplinary SC Chemistry; Engineering; Materials Science GA 283SB UT WOS:000254655700001 ER PT J AU Zhao, YB Fang, SC Lavery, JE AF Zhao, Y. B. Fang, S. -C. Lavery, J. E. TI Geometric dual formulation for first-derivative-based univariate cubic L-1 splines SO JOURNAL OF GLOBAL OPTIMIZATION LA English DT Article; Proceedings Paper CT 1st International Conference on Complementarity, Duality and Global Optimization in Science and Engineering CY AUG 15-17, 2005 CL Virginia Tech, Blacksburg, VA HO Virginia Tech DE conjugate function; convex program; cubic L-1 spline; shape-preserving interpolation; piecewise polynomial ID SMOOTHING SPLINES; EXTREMAL PROBLEMS; PERFECT SPLINES; INTERPOLATION AB With the objective of generating "shape-preserving" smooth interpolating curves that represent data with abrupt changes in magnitude and/or knot spacing, we study a class of first-derivative-based C-1-smooth univariate cubic L-1 splines. An L-1 spline minimizes the L-1 norm of the difference between the first-order derivative of the spline and the local divided difference of the data. Calculating the coefficients of an L-1 spline is a nonsmooth non-linear convex program. Via Fenchel's conjugate transformation, the geometric dual program is a smooth convex program with a linear objective function and convex cubic constraints. The dual-to-primal transformation is accomplished by solving a linear program. C1 [Fang, S. -C.] N Carolina State Univ, Raleigh, NC 27695 USA. [Zhao, Y. B.] Chinese Acad Sci, Inst Appl Math, AMSS, Beijing 100080, Peoples R China. [Fang, S. -C.] Tsinghua Univ, Dept Math Sci & Ind Engn, Beijing 100084, Peoples R China. [Lavery, J. E.] USA, Res Off, Res Lab, Div Math, Res Triangle Pk, NC 27709 USA. RP Fang, SC (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA. EM ybzhao@amss.ac.cn; fang@eos.ncsu.edu; john.lavery2@us.army.mil NR 30 TC 6 Z9 6 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0925-5001 EI 1573-2916 J9 J GLOBAL OPTIM JI J. Glob. Optim. PD APR PY 2008 VL 40 IS 4 BP 589 EP 621 DI 10.1007/s10898-006-9124-y PG 33 WC Operations Research & Management Science; Mathematics, Applied SC Operations Research & Management Science; Mathematics GA 267RY UT WOS:000253528100006 ER PT J AU Brininger, T AF Brininger, Teresa TI Untitled SO JOURNAL OF HAND THERAPY LA English DT Editorial Material C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Brininger, T (reprint author), USA, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. EM teresa.brininger@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 103 EP 103 DI 10.1197/j.jht.2007.12.005 PG 1 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500001 ER PT J AU Brininger, TL Antczak, A Breland, HL AF Brininger, Teresa L. Antczak, Amanda Breland, Hazel L. TI Upper extremity injuries in the US military during peacetime years and wartime years SO JOURNAL OF HAND THERAPY LA English DT Article; Proceedings Paper CT Conference on the Contributions of the Military Hand Therapist in Combat and Postdeployment Rehabilitation CY 2005 CL San Antonio, TX SP Brook Army Med Ctr ID OPERATION-ENDURING-FREEDOM; INFANTRY SOLDIERS; IRAQI-FREEDOM; RISK-FACTORS; ARMY; EPIDEMIOLOGY; PREVALENCE; EXPERIENCE; WAR C1 [Brininger, Teresa L.; Antczak, Amanda] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Brininger, TL (reprint author), USA, Environm Med Res Inst, 15 Kansas St,Bldg42, Natick, MA 01760 USA. EM Teresa.Brininger@us.army.mil NR 29 TC 9 Z9 9 U1 0 U2 0 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 115 EP 122 DI 10.1197/j.jht.2007.10.010 PG 8 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500004 PM 18436132 ER PT J AU Amaker, RJ Brower, KA Admire, DW AF Amaker, Robinette J. Brower, Kurt A. Admire, David W. TI The role of the upper extremity neuromusculoskeletal evaluator at peace and at war SO JOURNAL OF HAND THERAPY LA English DT Article; Proceedings Paper CT Conference on the Contributions of the Military Hand Therapist in Combat and Postdeployment Rehabilitation CY 2005 CL San Antonio, TX SP Brook Army Med Ctr C1 [Amaker, Robinette J.] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Brower, Kurt A.] 30 Med Brigade Clin Operat, Heidelberg, Germany. [Admire, David W.] Carl R Darnall Army Med Ctr, Dept Orthopaed & Rehabil Serv, Ft Hood, TX USA. RP Amaker, RJ (reprint author), USA, Med Dept Ctr & Sch, 2260 Stanley Rd,Suite 272, Ft Sam Houston, TX 78234 USA. EM robinette.amaker@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 2 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 124 EP 128 DI 10.1197/j.jht.2007.10.011 PG 5 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500005 PM 18436133 ER PT J AU Montz, R Gonzales, F Bash, DS Carney, A AF Montz, Robert Gonzales, Florie, Jr. Bash, Daniel S. Carney, Avery TI Occupational therapy role on the battlefield: An overview of combat and operational stress and upper extremity rehabilitation SO JOURNAL OF HAND THERAPY LA English DT Article; Proceedings Paper CT Conference on the Contributions of the Military Hand Therapist in Combat and Postdeployment Rehabilitation CY 2005 CL San Antonio, TX SP Brook Army Med Ctr AB What happens when the stressors of combat, fatigue, separation, and personal conflict affect a Soldier's ability to perform their wartime mission? What happens when an upper extremity injury or a significant trauma impacts a Soldier's ability to fire their weapon or complete their mission? The Army has specialized units known as Combat Operational Stress Control (COSC) Detachments and Combat Support Hospitals (CSHs) deployed on the battlefield to address these issues. Occupational therapists (OTs) work in these units and are responsible for facilitating function when Soldiers are faced with these physical and mental injuries. OTs are involved before, during, and after deployment educating, evaluating, and treating units, leadership, commanders, and Soldiers on a myriad of skills, activities, and tasks that enable Soldiers to optimize their overall performance. The history, functional areas, and specific roles of OT in the COSC unit and in the CSH will be discussed in this article. The effectiveness of occupational therapy intervention in these types of units will be discussed in case studies. C1 [Montz, Robert] 75 Ranger Regiment, Ft Benning, GA USA. [Gonzales, Florie, Jr.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Bash, Daniel S.] 338 Med Co, Ft Devens, MA USA. [Carney, Avery] 601 Area Support Med Co, Ft Bragg, NC USA. RP Montz, R (reprint author), 10 Lee Rd, Phenix City, AL 36870 USA. EM robert.montz@us.army.mil NR 3 TC 5 Z9 5 U1 0 U2 2 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 130 EP 135 DI 10.1197/j.jht.2007.12.008 PG 6 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500006 PM 18436134 ER PT J AU Konitzer, LN Fargo, MV Brininger, TL Reed, ML AF Konitzer, Lisa N. Fargo, Matthew V. Brininger, Teresa L. Reed, Mary Lim TI Association between back, neck, and upper extremity musculoskeletal pain and the individual body armor SO JOURNAL OF HAND THERAPY LA English DT Article; Proceedings Paper CT Conference on the Contributions of the Military Hand Therapist in Combat and Postdeployment Rehabilitation CY 2005 CL San Antonio, TX SP Brook Army Med Ctr ID BATTLEFIELD; INJURIES; SOLDIERS; IRAQ AB The purpose of this study was to investigate the relationship between back, neck, and upper extremity (UE) musculoskeletal pain and the wear of individual body armor, physical training (PT), and work tasks. We conducted a cross-sectional randomized-survey design in which 1,187 surveys were distributed to U.S. Soldiers in Iraq; 863 were completed. The survey was a three-page questionnaire covering demographics, body armor wear, PT, and reports of neck, back, and UE musculoskeletal pain before and during deployment. The results of the survey revealed a substantial increase in the incidence of back, neck, and UE pain during deployment, and approximately twice as many Soldiers attributed their musculoskeletal pain to wearing body armor than to job tasks and PT. In addition, there was a significant positive correlation between Soldiers who wore the body armor for four hours or more a day and self-reported musculoskeletal complaints. These results demonstrate a need to consider the potential adverse effects of individual body armor on combat Soldiers. C1 [Konitzer, Lisa N.; Fargo, Matthew V.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Brininger, Teresa L.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Reed, Mary Lim] Bassett Army Community Hosp, Kamish Hlth Clin, Ft Wainwright, AK 99703 USA. RP Konitzer, LN (reprint author), Madigan Army Med Ctr, Tacoma, WA 98431 USA. EM lisa.konitzer@us.army.mil NR 15 TC 34 Z9 34 U1 2 U2 3 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 143 EP 148 DI 10.1197/j.jht.2007.10.017 PG 6 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500008 PM 18436136 ER PT J AU Chapman, TT Richard, RL Hedman, TL Renz, EM Wolf, SE Holcomb, JB AF Chapman, Ted T. Richard, Reg L. Hedman, Travis L. Renz, Evan M. Wolf, Steve E. Holcomb, John B. TI Combat casualty hand burns: Evaluating impairment and disability during recovery SO JOURNAL OF HAND THERAPY LA English DT Article; Proceedings Paper CT Conference on the Contributions of the Military Hand Therapist in Combat and Postdeployment Rehabilitation CY 2005 CL San Antonio, TX SP Brook Army Med Ctr ID INJURIES; ARM; REHABILITATION; QUESTIONNAIRE; MANAGEMENT; SHOULDER; CARE AB This study evaluated the use of the American Medical Association (AMA) impairment guides and Disabilities of the Ann, Shoulder, and Hand (DASH) questionnaire in U.S. military casualties recovering from burn injury to the hand. Study sample included patients with burns to at least one hand and complete evaluations of impairment and disability upon discharge from the hospital and at a follow-up visit less than four months later. AMA and DASH scores were calculated for each visit and standardized response means (SRMs) were calculated to indicate responsiveness. Correlation between impairment and disability was assessed at discharge and follow-up and scores were examined for ability to discriminate between casualties returned to duty (RTD) and casualties not returned to duty (N-RTD). Both outcome instruments revealed a statistically significant change in scores between visits (p < 0.001) with corresponding SRM indexes greater than 0.8 (large effect). There was a moderate correlation (r = 0.50) between impairment and disability at discharge and a moderately high correlation (r = 0.74) at follow-up. Both AMA and DASH scores clearly discriminated between casualties RTD (AMA 10 +/- 10 and DASH 12 +/- 12) and casualties N-RTD (AMA 39 +/- 19 and DASH 41 +/- 17) with improved accuracy at follow-up visit. The AMA and DASH can provide a comprehensive assessment of impairment and disability and may be used to detect changes in patient health status over time while clearly discriminating between RTD and N-RTD in combat casualties recovering from burn injury to the hand(s). C1 [Chapman, Ted T.; Richard, Reg L.; Hedman, Travis L.; Renz, Evan M.; Wolf, Steve E.; Holcomb, John B.] USA, Inst Surg Res, ATTN MCMR, USC,PT, Ft Sam Houston, TX 78234 USA. RP Richard, RL (reprint author), USA, Inst Surg Res, ATTN MCMR, USC,PT, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM reginald.richard@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 30 TC 10 Z9 10 U1 0 U2 2 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 150 EP 158 DI 10.1197/j.jht.2007.12.003 PG 9 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500009 PM 18436137 ER PT J AU Smurr, LM Gulick, K Yancosek, K Ganz, O AF Smurr, Lisa M. Gulick, Kristin Yancosek, Kathleen Ganz, Oren TI Managing the upper extremity amputee: A protocol for success SO JOURNAL OF HAND THERAPY LA English DT Article; Proceedings Paper CT Conference on the Contributions of the Military Hand Therapist in Combat and Postdeployment Rehabilitation CY 2005 CL San Antonio, TX SP Brook Army Med Ctr ID PHANTOM LIMBS AB Since the beginning of Operation Enduring Freedom and Operation Iraqi Freedom, over 541 clients with major limb amputations have been seen in the Military Healthcare System. As a result of the nature and severity of injuries and the prevalence of concomitant injuries seen in this population, amputee care has become a specialized type of rehabilitative care at Walter Reed and Brooke Army Medical Centers. To streamline and accommodate the needs of clients with upper extremity limb loss, a five-phased upper extremity amputee protocol of care was developed. The five phases of the protocol include acute management; preprosthetic training; basic prosthetic training; advanced prosthetic training; and discharge planning. For the readers ease, these phases will be presented in the following categories: acute care, subacute care, and long-term rehabilitation needs. Furthermore, this article seeks to offer insight into the ideal treatment of an individual with upper extremity limb loss based on experience and collective expertise of the authoring therapists. C1 [Smurr, Lisa M.] USA, Hlth Clin Schofield Barracks, Schofield Barracks, HI 96789 USA. [Gulick, Kristin] Adv Arm Dynam, Portland, OR USA. [Yancosek, Kathleen; Ganz, Oren] Water Reed Army Med Ctr, Washington, DC USA. RP Smurr, LM (reprint author), USA, Hlth Clin Schofield Barracks, 95-1007 Kuauli St 144 Mililani, Schofield Barracks, HI 96789 USA. EM lisa.smurr@us.army.mil NR 18 TC 42 Z9 43 U1 1 U2 8 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 160 EP 175 DI 10.1197/j.jht.2007.09.006 PG 16 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500010 PM 18436138 ER PT J AU Smurr, LM Robinson, M Smith-Forbes, E AF Smurr, Lisa M. Robinson, Michael Smith-Forbes, Enrique TI Treating the war casualty: Case reports of polytrauma SO JOURNAL OF HAND THERAPY LA English DT Article; Proceedings Paper CT Conference on the Contributions of the Military Hand Therapist in Combat and Postdeployment Rehabilitation CY 2005 CL San Antonio, TX SP Brook Army Med Ctr AB The new generation of wounded Warriors is vastly different from those seen in the past, and military occupational therapists (OTs) must adapt to the challenges to meet the needs of these young men and women. Three case reports will be presented demonstrating the adaptability and flexibility of military OTs serving the combat wounded Warrior. The first case report reviews the rehabilitation process of a Sailor who was hit by an improvised explosive device (IED) and sustained an open shrapnel wound to his left upper extremity. The second case report presents the complex rehabilitation process of a Soldier who sustained an open distal radius and carpal fractures with soft tissue loss to his left hand from a gunshot wound after his helicopter was shot down. The final case report represents a Soldier who was injured using a table saw while in Iraq and sustained lacerations to his left hand thumb, index, and ring fingers. These case reports represent some of the demands and challenges that military OTs face when treating the war casualty. C1 [Smurr, Lisa M.] USA, Hlth Clin Schofield Barracks, ATTN MCHK, HC A, Schofield Barracks, HI 96857 USA. [Robinson, Michael] Naval Hosp Okinawa, Okinawa, Japan. [Smith-Forbes, Enrique] USA, Med Detachment CSC 98, Washington, DC USA. RP Smurr, LM (reprint author), USA, Hlth Clin Schofield Barracks, ATTN MCHK, HC A, Schofield Barracks, HI 96857 USA. EM lisa.smurr@us.army.mil NR 10 TC 4 Z9 4 U1 2 U2 4 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 177 EP 187 DI 10.1197/j.jht.2007.09.002 PG 11 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500011 PM 18436139 ER PT J AU Yancosek, K Daugherty, SE Cancio, L AF Yancosek, Katie Daugherty, Stephanie E. Cancio, Leonard TI Treatment for the service member: A description of innovative interventions SO JOURNAL OF HAND THERAPY LA English DT Article; Proceedings Paper CT Conference on the Contributions of the Military Hand Therapist in Combat and Postdeployment Rehabilitation CY 2005 CL San Antonio, TX SP Brook Army Med Ctr ID VIRTUAL-REALITY; TECHNOLOGY AB This article describes advances to the rehabilitation programs at major military medical centers since the onset of operations in Iraq and Afghanistan. The demands on military health care in times of war produce advances in the various rehabilitation professions. This article describes two programs that use new technologies for the care of military patients with devastating injuries to the upper extremity. One project relates to the application of voice-sensitive technology. The other project describes the utilization of virtual reality technology through a Firearm Training System. The article also explains an adaptive sports program and how recreation is part of a robust community reintegration program. Lastly, this article discusses the Center for the Intrepid, which is one of two new amputee care centers built to support the advanced rehabilitation of war-wounded amputees. C1 [Yancosek, Katie; Daugherty, Stephanie E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Cancio, Leonard] Brooke Army Med Ctr, San Antonio, TX USA. RP Yancosek, K (reprint author), 923 Forest Lake Dr, Lexington, KY 40515 USA. EM Kathleen.yancosek@us.army.mil NR 9 TC 10 Z9 12 U1 0 U2 5 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 189 EP 194 DI 10.1197/j.jht.2007.12.002 PG 6 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500012 PM 18436140 ER PT J AU Yeager, AE Faillace, JJ AF Yeager, Arthur E. Faillace, John J. TI Dynamic supination-flexion splinting for the postoperative management of distal biceps injuries SO JOURNAL OF HAND THERAPY LA English DT Editorial Material ID TENDON RUPTURES; REPAIR; BRACHII C1 [Yeager, Arthur E.] Army Med Specialist Corps, Occupat Therapy Orthoped & Rehabil, Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Faillace, John J.] Hillcrest Baptist Med Ctr, Waco, TX USA. RP Yeager, AE (reprint author), Army Med Specialist Corps, Occupat Therapy Orthoped & Rehabil, Walter Reed Army Med Ctr, 6900 Georgia, Washington, DC 20307 USA. EM arthur.yeager@us.army.mil NR 16 TC 0 Z9 0 U1 0 U2 0 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 204 EP 208 DI 10.1197/j.jht.2007.08.020 PG 5 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500014 PM 18436142 ER PT J AU Goldman, RSB Amaker, RJ Espinosa, RA AF Goldman, R. Sarah B. Amaker, Robinette J. Espinosa, Randall A. TI James traction splinting for PIP fractures SO JOURNAL OF HAND THERAPY LA English DT Editorial Material ID PROXIMAL INTERPHALANGEAL JOINT; DYNAMIC EXTERNAL FIXATION; INTRAARTICULAR FRACTURES; PHALANGEAL FRACTURES; INTERNAL-FIXATION; OPEN REDUCTION; WIRE FIXATION; HAND; DISLOCATION; MOVEMENT C1 [Goldman, R. Sarah B.] USN, Med Serv Corps, Naval Med Educ & Traning Command, Bethesda, MD 20084 USA. [Amaker, Robinette J.] Army Med Specialist Corps, Occupat Therapy Educ, Army Med Dept Ctr & Sch, San Antonio, TX USA. [Espinosa, Randall A.] Army Med Corps, Orthopaed & Hand Surg, FT Bragg, NC USA. RP Goldman, RSB (reprint author), USN, Med Serv Corps, Naval Med Educ & Traning Command, Bethesda, MD 20084 USA. EM sbgoldma@indiana.edu NR 38 TC 1 Z9 1 U1 0 U2 0 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2008 VL 21 IS 2 BP 209 EP 215 DI 10.1197/j.jht.2007.08.019 PG 7 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 299PW UT WOS:000255768500015 ER PT J AU Hasan, S Ghosh, TK Viswanath, DS Boddu, VM AF Hasan, Shameem Ghosh, Tushar K. Viswanath, Dabir S. Boddu, Veera M. TI Dispersion of chitosan on perlite for enhancement of copper(II) adsorption capacity SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE chitosan; perlite; copper; adsorption; regeneration ID AQUEOUS-SOLUTIONS; METAL-IONS; HEXAVALENT CHROMIUM; URANIUM BIOSORPTION; ACTIVATED CARBON; CHELATING-AGENTS; FISHERY WASTES; COATED PERLITE; HEAVY-METALS; REMOVAL AB Chitosan coated perlite beads were prepared by drop-wise addition of slurry, made of chitosan dissolved in oxalic acid and perlite, to an alkaline bath (0.7 M NaOH). The beads that contained 32% chitosan enhanced the accessibility of OH and amine groups present in chitosan for adsorption of copper ions. The experiments using Cu(II) ions were carried out in the concentration range of 50-4100 mg/L (0.78-64.1 mmol/L). Adsorption capacity for Cu(II) was pH dependent and a maximum uptake of 104 mg/g of beads (325 mg/g of chitosan) was obtained at pH 4.5 when its equilibrium concentration in the solution was 812.5 mg/L at 298 K. The XPS and TEM data suggested that copper was mainly adsorbed as Cu(II) and was attached to arrime groups. The adsorption data could be fitted to one-site Langmuir adsorption model. Anions in the solution had minimal effect on Cu(II) adsorption by chitosan coated perlite beads. EDTA was used effectively for the regeneration of the bed. The diffusion coefficient of Cu(H) onto chitosan coated beads was calculated from the breakthrough curve and was found to be 2.02 x 10(-8) cm(2)/s. (c) 2007 Elsevier B.V. All rights reserved. C1 [Hasan, Shameem; Ghosh, Tushar K.; Viswanath, Dabir S.] Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. [Boddu, Veera M.] USA, Ctr Res Dev & Engn, Construct Engn Res Labs, Environm Proc Branch CN E, Champaign, IL 61826 USA. RP Ghosh, TK (reprint author), Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. EM ghoshT@missouri.edu NR 50 TC 54 Z9 55 U1 1 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD APR 1 PY 2008 VL 152 IS 2 BP 826 EP 837 DI 10.1016/j.jhazmat.2007.07.078 PG 12 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 285GK UT WOS:000254765100046 PM 17850957 ER PT J AU Essery, R Bunting, P Hardy, J Link, T Marks, D Melloh, R Pomeroy, J Rowlands, A Rutter, N AF Essery, Richard Bunting, Peter Hardy, Janet Link, Tim Marks, Danny Melloh, Rae Pomeroy, John Rowlands, Aled Rutter, Nick TI Radiative transfer modeling of a coniferous canopy characterized by airborne remote sensing SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID FOREST CANOPIES; SPATIAL-PATTERNS; TREE CROWNS; TRANSMISSION; REFLECTANCE; DELINEATION; PARAMETERS; DEPLETION; AREA AB Solar radiation beneath a forest canopy can have large spatial variations, but this is frequently neglected in radiative transfer models for large-scale applications. To explicitly model spatial variations in subcanopy radiation, maps of canopy structure are required. Aerial photography and airborne laser scanning are used to map tree locations, heights, and crown diameters for a lodgepole pine forest in Colorado as inputs to a spatially explicit radiative transfer model. Statistics of subcanopy radiation simulated by the model are compared with measurements from radiometer arrays, and scaling of spatial statistics with temporal averaging and array size is discussed. Efficient parameterizations for spatial averages and standard deviations of subcanopy radiation are developed using parameters that can be obtained from the model or hemispherical photography. C1 [Essery, Richard; Bunting, Peter; Rowlands, Aled; Rutter, Nick] Univ Wales, Inst Geog & Earth Sci, Aberystwyth, Dyfed, Wales. [Hardy, Janet; Melloh, Rae] Cold Reg Res & Engn Lab, Hanover, NH USA. [Link, Tim] Univ Idaho, Moscow, ID 83843 USA. [Marks, Danny] Northwest Watershed Res Ctr, Boise, ID USA. [Pomeroy, John] Univ Saskatchewan, Ctr Hydrol, Saskatoon, SK, Canada. RP Essery, R (reprint author), Univ Edinburgh, Grant Inst Geol, Sch Geol Sci, Edinburgh EH9 3JW, Midlothian, Scotland. EM richard.essery@ed.ac.uk RI Link, Timothy/G-5556-2012; Pomeroy, John/A-8589-2013; Bunting, Peter/B-8678-2013; Rutter, Nick/F-6998-2014; OI Pomeroy, John/0000-0002-4782-7457; Bunting, Peter/0000-0002-7435-0148; Rutter, Nick/0000-0002-5008-3575; Essery, Richard/0000-0003-1756-9095 NR 39 TC 39 Z9 40 U1 2 U2 19 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X EI 1525-7541 J9 J HYDROMETEOROL JI J. Hydrometeorol. PD APR PY 2008 VL 9 IS 2 BP 228 EP 241 DI 10.1175/2007JHM870.1 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 287DM UT WOS:000254897100004 ER PT J AU Carpenter, RJ Hartzell, JD Forsberg, JA Babel, BS Ganesan, A AF Carpenter, Robert J. Hartzell, Joshua D. Forsberg, Jonathan A. Babel, Britta S. Ganesan, Anuradha TI Pseudomonas putida war wound infection in a US Marine: A case report and review of the literature SO JOURNAL OF INFECTION LA English DT Review DE Pseudomonas putida; infection; Pseudomonas; Pseudomonas infections; humans; war; review; cross infection ID METALLO-BETA-LACTAMASE; PERITONEAL-DIALYSIS; SEPTIC ARTHRITIS; BACTEREMIA; OUTBREAK; IRAQ; AERUGINOSA; RESISTANCE; SEPSIS; INJURY AB US service members are returning from the war in Iraq and Afghanistan with wound infections due to uncommon bacteria. Pseudomonas putida, a member of the fluorescent group of pseudomonads, primarily causes infection in immunosuppressed hosts and patients with invasive medical devices. P. putida has been implicated in outbreaks often traced to a contaminated fluid and is a rare cause of clinical infection. However, it should be considered a pathogen when isolated from pure culture. The objective of this article is to present a case report of a P. putida war wound infection, review previous P. putida infections, and provide a concise review of the epidemiology, risk factors, and management of infections due to this organism. Published by Elsevier Ltd on behalf of The British Infection Society. C1 Natl Naval Med Ctr, Dept Internal Med, Gaithersburg, MD 20899 USA. [Hartzell, Joshua D.] Walter Reed Army Med Ctr, Dept Infect Dis, Washington, DC 20012 USA. [Forsberg, Jonathan A.] Natl Naval Med Ctr, Walter Reed Army Med Ctr, Integrated Dept Orthoped & Rehabil, Bethesda, MD 20889 USA. [Babel, Britta S.] Natl Naval Med Ctr, Clin Lab, Bethesda, MD 20889 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Dept Infect Dis, Bethesda, MD 20889 USA. [Ganesan, Anuradha] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. RP Carpenter, RJ (reprint author), Natl Naval Med Ctr, Dept Internal Med, 8901 Rockville Pike, Gaithersburg, MD 20899 USA. EM Robert.Carpenter@med.navy.mil RI Forsberg, Jonathan/K-2116-2012; OI Carpenter, Robert/0000-0002-6546-6122 NR 42 TC 23 Z9 25 U1 0 U2 5 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0163-4453 J9 J INFECTION JI J. Infect. PD APR PY 2008 VL 56 IS 4 BP 234 EP 240 DI 10.1016/j.jinf.2008.01.004 PG 7 WC Infectious Diseases SC Infectious Diseases GA 293KY UT WOS:000255335400002 PM 18294694 ER PT J AU Patel, GK Lee, CL Montemarano, A Maggio, K Vogel, JC AF Patel, G. K. Lee, C. L. Montemarano, A. Maggio, K. Vogel, J. C. TI Development of human non-melanoma skin cancer stem cell assays SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT International Investigative Dermatology Meeting CY MAY 14-17, 2008 CL Kyoto, JAPAN SP Japanese Soc Investigat Dermatol, Soc Investigat Dermatol, European Soc Dermatol Res, Federat Pharmaceut Manufactures Assoc Japan, Galderma, Janssen Pharmaceut KK, Maruho Co Ltd, Sanofi Aventis KK, Torii Pharmaceut Co Ltd, Abbott Japan Co Ltd, CERIES, Chanel, Clin Labs KK, Dainippon Sumitomo Pharma, Eisai Co Ltd, GlaxoSmithKline KK, Kyowa Hakko Kogyo Co Ltd, Mistubishi Tanabe Pharma Corp, Nippon Boehringer Ingelheim, Novartis Pharma KK, Schering Plough, Shionogi & Co Ltd, Shiseido Co Ltd, Japan Cosmet Ind Assoc, Igaku Shoin, Pierre Fabre Japan Co Ltd C1 [Patel, G. K.; Lee, C. L.; Vogel, J. C.] NCI, Dermatol Branch, Bethesda, MD 20892 USA. [Montemarano, A.] Rockledge Skin Canc Ctr, Bethesda, MD USA. [Maggio, K.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2008 VL 128 SU 1 BP S33 EP S33 PG 1 WC Dermatology SC Dermatology GA 279KJ UT WOS:000254353800198 ER PT J AU Martin, M Kecskes, L Thadhan, NN AF Martin, Morgana Kecskes, Laszlo Thadhan, Naresh N. TI High-strain-rate dynamic mechanical behavior of a bulk metallic glass composite SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID CONSTITUTIVE MODEL VALIDATION; SERRATED PLASTIC-FLOW; MATRIX COMPOSITES; AMORPHOUS-ALLOYS; RATE SENSITIVITY; FRACTURE; DEFORMATION; TUNGSTEN; STRENGTH; MICROSTRUCTURE AB The high-strain-rate mechanical properties, deformation mechanisms, and fracture characteristics of a bulk metallic glass (BMG)-matrix composite, consisting of an amorphous Zr57Nb5Cu15.4Ni12.6Al10 (LM106) matrix with crystalline tungsten reinforcement particles, were investigated using gas gun anvil-on-rod impact experiments instrumented with velocity, interferometry (VISAR) and high-speed digital photography. The time-resolved elastic-plastic wave propagation response obtained through VISAR and the transient deformation states captured with the camera provided information about dynamic strength and deformation modes of the composite. Comparison of experimental measurements with AUTODYN-simulated transient deformation profiles and free surface velocity traces allowed for validation of the pressure-hardening Drucker-Prager model, which was used to describe the deformation response of the composite. The impacted specimens recovered for post-impact microstructural analysis provided further information about the mechanisms of dynamic deformation and fracture characteristics. The overall results from experiments and modeling revealed a strain to failure of similar to 45% along the length and similar to 7% in area, and the fracture initiation stress was found to decrease with increasing impact velocity because of the negative strain-rate sensitivity of the BMG. C1 [Martin, Morgana; Thadhan, Naresh N.] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. [Kecskes, Laszlo] USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM MB, Aberdeen Proving Ground, MD 21005 USA. RP Thadhan, NN (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. EM naresh.thadhani@mse.gatech.edu RI Trexler, Morgana/E-9003-2013; Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 37 TC 3 Z9 3 U1 1 U2 8 PU MATERIALS RESEARCH SOC PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD APR PY 2008 VL 23 IS 4 BP 998 EP 1008 DI 10.1557/JMR.2008.0119 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 284DB UT WOS:000254684500017 ER PT J AU Brunye, TT Taylor, HA AF Brunye, Tad T. Taylor, Holly A. TI Working memory in developing and applying mental models from spatial descriptions SO JOURNAL OF MEMORY AND LANGUAGE LA English DT Article DE spatial mental models; working memory; discourse processing ID LATENT-VARIABLE ANALYSIS; SITUATION MODELS; NARRATIVE COMPREHENSION; COGNITIVE MAPS; ARTICULATORY SUPPRESSION; DISCOURSE COMPREHENSION; ROUTE DESCRIPTIONS; RANDOM GENERATION; SENTENCE MEMORY; FRONTAL-LOBE AB Four dual-task experiments examined visuospatial, articulatory, and central executive working memory involvement during the development and application of spatial mental models. In Experiments I and 2 participants read route and survey spatial descriptions while undertaking one of four secondary tasks targeting working memory components. Converging evidence from map drawing and statement verification tasks indicates that while articulatory mechanisms are involved in processing the language itself, visuospatial and central executive mechanisms are involved in developing spatial mental models, particularly during route description reading. In Experiments 3 and 4 participants undertook the same working memory tasks, but did so during testing; results from memory and secondary task performance converge to demonstrate that using spatial mental models is a visuospatially and centrally demanding process, particularly following route description learning. Taken together, results demonstrate that spatial mental model development and application are contingent upon multiple working memory systems and interact with representational formats. (C) 2007 Elsevier Inc. All rights reserved. C1 [Brunye, Tad T.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.] USA, RDEC, Natick, MA 01760 USA. RP Brunye, TT (reprint author), Cognit Sci USA RDEC, Bldg 4,Off 126 Kansas St AMSRD NSC WS P, Natick, MA 01760 USA. EM tbrunye@alumni.tufts.edu NR 98 TC 42 Z9 42 U1 4 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0749-596X EI 1096-0821 J9 J MEM LANG JI J. Mem. Lang. PD APR PY 2008 VL 58 IS 3 BP 701 EP 729 DI 10.1016/j.jml.2007.08.003 PG 29 WC Linguistics; Psychology; Psychology, Experimental SC Linguistics; Psychology GA 288SJ UT WOS:000255005800006 ER PT J AU Biddle, TD AF Biddle, Tami Davis TI Dresden 1945: Reality, history, and memory SO JOURNAL OF MILITARY HISTORY LA English DT Article AB The Anglo-American air attack on the city of Dresden, in February 1945, has become one of the most famous events of the Second World War. The word "Dresden" is typically one of the first uttered whenever the topic of strategic bombing is raised. And yet, like many other high-profile historical events, the Dresden raid is encrusted with myth and misunderstanding. This essay is an effort to make sense of a complicated and much misunderstood episode in the history of modern warfare-and to make sense of it in the context in which it occurred. The essay draws upon the rich recent literature on Dresden, earlier histories, and a wide array of primary sources in an effort to provide - for teachers, scholars, and general readers - a comprehensive but still concise overview of the air raid that has won such a central place in the history of the Second World War. C1 USA, War Coll, Washington, DC 20310 USA. RP Biddle, TD (reprint author), USA, War Coll, Washington, DC 20310 USA. NR 45 TC 7 Z9 7 U1 4 U2 8 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2008 VL 72 IS 2 BP 413 EP 449 DI 10.1353/jmh.2008.0074 PG 37 WC History SC History GA 283KN UT WOS:000254635200003 ER PT J AU King, CS AF King, Curtis S. TI Friends or foes? The United States & Soviet Russia, 1921-1941 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [King, Curtis S.] Combat Studies Inst, Ft Leavenworth, KS USA. RP King, CS (reprint author), Combat Studies Inst, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2008 VL 72 IS 2 BP 601 EP 602 DI 10.1353/jmh.2008.0075 PG 2 WC History SC History GA 283KN UT WOS:000254635200054 ER PT J AU Cirillo, R AF Cirillo, Roger TI Alamo in the Ardennes: The untold story of the American soldiers who made the defense of Bastogne possible SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Cirillo, Roger] Assoc US Army, Arlington, VA USA. RP Cirillo, R (reprint author), Assoc US Army, Arlington, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2008 VL 72 IS 2 BP 609 EP 610 DI 10.1353/jmh.2008.0081 PG 2 WC History SC History GA 283KN UT WOS:000254635200060 ER PT J AU Fischer, JR AF Fischer, Joseph R. TI US special forces and counterinsurgency in Vietnam: Military innovation and institutional failure, 1961-1963 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Fischer, Joseph R.] CGSC, DMH, Ft Leavenworth, KS USA. RP Fischer, JR (reprint author), CGSC, DMH, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2008 VL 72 IS 2 BP 620 EP 622 DI 10.1353/jmh.2008.0112 PG 3 WC History SC History GA 283KN UT WOS:000254635200068 ER PT J AU House, JM AF House, Jonathan M. TI From Detente to the Soviet Collapse: The Cold War from 1975 to 1991 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2008 VL 72 IS 2 BP 624 EP 625 DI 10.1353/jmh.2008.0079 PG 2 WC History SC History GA 283KN UT WOS:000254635200071 ER PT J AU Grau, LW AF Grau, Lester W. TI Koran, kalashnikov, and laptop: The Neo-Taliban insurgency in Afghanistan SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Grau, Lester W.] Foreign Mil Studies Off, Ft Leavenworth, KS USA. RP Grau, LW (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2008 VL 72 IS 2 BP 630 EP 630 DI 10.1353/jmh.2008.0136 PG 1 WC History SC History GA 283KN UT WOS:000254635200076 ER PT J AU Work, TM Takata, G Whipps, CM Kent, ML AF Work, Thierry M. Takata, Geraldine Whipps, Christopher M. Kent, Michael L. TI A new species of Henneguya (myxozoa) in the big-eyed SCAD (Selar crumenophthalmus) from Hawaii SO JOURNAL OF PARASITOLOGY LA English DT Article ID N. SP MYXOZOA; CARDIAC HENNEGUYOSIS; RED-SEA; MYXOSPOREA; PHYLOGENY; KUDOIDAE; FISHES; HEART AB We describe anew myxozoan, Henneguya akule n. sp., infecting the carangid fish Selar crumenophthalmus in Hawaii. Spores were found only in the aortic bulb, characterized by elliptical capsule with 2 tails, and pyriform polar capsules that angled toward the anterior end of the spore. Polar filaments had 3-4 coils. Parasites were present in apparently healthy fishes and caused no evident gross pathology. On microscopy, parasites evinced a mild inflammatory response in the host characterized by accumulations of eosinophilic fibrillar material around spores and a mononuclear infiltrate in the adventitia of the bulbus arteriosus. Overall prevalence was 20%, and prevalence between 2001 and 2006 ranged from 12 to 27%, but did not differ significantly between years. In contrast, prevalence of infection was highest in south-central Oahu. There was no relationship between infection status and body condition or gender of fish, and infection was absent in the smallest and largest fishes. Phylogenetically, H. akule n. sp. is most closely related to other Henneguya species infecting the heart of marine fishes based on ribosomal DNA analysis. This is the first documentation of a myxozoan parasite in marine fishes from Hawaii. C1 [Work, Thierry M.] US Geol Survey, Natl Wildlife Hlth Ctr, Honolulu Field Stn, Honolulu, HI 96850 USA. [Takata, Geraldine] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. [Whipps, Christopher M.; Kent, Michael L.] Oregon State Univ, Dept Microbiol, Ctr Fish Dis Res, Corvallis, OR 97331 USA. RP Work, TM (reprint author), US Geol Survey, Natl Wildlife Hlth Ctr, Honolulu Field Stn, 300 Ala Moana Blvd,Room 5-231, Honolulu, HI 96850 USA. EM thierry_work@usgs.gov RI Work, Thierry/F-1550-2015; OI Work, Thierry/0000-0002-4426-9090; Whipps, Christopher/0000-0001-6139-0426 NR 28 TC 9 Z9 9 U1 0 U2 2 PU AMER SOC PARASITOLOGISTS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0022-3395 J9 J PARASITOL JI J. Parasitol. PD APR PY 2008 VL 94 IS 2 BP 524 EP 529 DI 10.1645/GE-1385.1 PG 6 WC Parasitology SC Parasitology GA 305VZ UT WOS:000256207200026 PM 18564755 ER PT J AU Britt, TW Greene-Shortridge, TM Brink, S Nguyen, QB Rath, J Cox, AL Hoge, CW Castro, CA AF Britt, Thomas W. Greene-Shortridge, Tiffany M. Brink, Sarah Nguyen, Quyen B. Rath, Jaclyn Cox, Anthony L. Hoge, Charles W. Castro, Carl Andrew TI Perceived stigma and barriers to care for psychological treatment: Implications for reactions to stressors in different contexts SO JOURNAL OF SOCIAL AND CLINICAL PSYCHOLOGY LA English DT Article ID MENTAL-HEALTH PROBLEMS; SOCIAL-PSYCHOLOGY; ILLNESS; REJECTION; MODERATOR; PEOPLE AB Two studies examined how perceiving a stigma and barriers to care for psychological treatment moderate the relationships between stressors and psychological symptoms. One study utilized a sample of college students and the other a sample of U.S. Army soldiers. Factor analytic results from the two samples supported stigma and barriers to care being separate constructs. In the student sample, perceived stigma interacted with subjective stress to predict depression, such that the relationship between stress and depression was stronger when perceived stigma was high. In the military sample, barriers to care interacted with work overload to predict depression, such that the relationship between overload and depression was stronger when perceived barriers to care were high. Results reveal the importance of examining both stigma and barriers to care as moderators of the stressor-strain relationship, and reinforce the need to develop interventions to address stigma and remove barriers to care. C1 [Britt, Thomas W.; Greene-Shortridge, Tiffany M.; Brink, Sarah; Nguyen, Quyen B.; Rath, Jaclyn] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. [Cox, Anthony L.; Hoge, Charles W.; Castro, Carl Andrew] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. RP Britt, TW (reprint author), Clemson Univ, Dept Psychol, 418 Brackett Hall, Clemson, SC 29634 USA. EM twbritt@clemson.edu NR 28 TC 69 Z9 69 U1 3 U2 15 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0736-7236 J9 J SOC CLIN PSYCHOL JI J. Soc. Clin. Psychol. PD APR PY 2008 VL 27 IS 4 BP 317 EP 335 DI 10.1521/jscp.2008.27.4.317 PG 19 WC Psychology, Clinical; Psychology, Social SC Psychology GA 296IW UT WOS:000255537700001 ER PT J AU Cohen, T Prus, D Shia, J Abu-Wasel, B Pinto, MG Freund, HR Stojadinovic, A Grakov, A Peretz, T Nissan, A AF Cohen, Tzeela Prus, Diana Shia, Jinru Abu-Wasel, Bassam Pinto, Meir G. Freund, Herbert R. Stojadinovic, Alexander Grakov, Anna Peretz, Tamar Nissan, Aviram TI Expression of p53, p27 and Ki-67 in colorectal cancer patients of various ethnic origins: Clinical and tissue microarray based analysis SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE colorectal neoplasms; microarray; p53; p21; Ki-67 ID KINASE INHIBITOR P27; COLON-CANCER; PROGNOSTIC-SIGNIFICANCE; CELL-CYCLE; IMMUNOHISTOCHEMICAL ANALYSIS; THYMIDYLATE SYNTHASE; BREAST-CANCER; CARCINOMA; MUTATIONS; P27(KIP1) AB Background: This study was conducted to determine survival according to the expression of molecular markers in colorectal cancer (CRC) patients of various ethnic origins. Methods: Resection of primary tumor was conducted on 171 patients with CRC. Corresponding archived paraffin-embedded blocks were retrieved and tissue microarray (TMA) constructed. Immunohistochemical staining of the TMA for p53, p27 and Ki-67 was quantified by two independent pathologists. Survival was analyzed using the Kaplan-Meier product limit method. Results: With a median follow-up of 65 months, 56 patients (32.7%) died of disease. AJCC stage correlated with disease-free (DFS, P < 0.0001) and overall survival (OS, P < 0.0001). IHC staining was positive for Ki-67 in 77.4%, p53 in 55.8% and p27 in 54.2% of patients. Primary tumor marker expression did not correlate with DFS or OS. The 5-year DFS for Ashkenazi Jews was 75%, significantly higher than Sephardic Jews (SJ) 64% and Palestinian Arabs (PA) 38%, P = 0.001. Conclusions: Ethnicity among Ashkenazi and SJ and PA appears to have a significant impact on disease outcome in patients with CRC patients, while primary tumor expression of p53, p27 and Ki-67 was unrelated to disease outcome. C1 [Cohen, Tzeela; Abu-Wasel, Bassam; Pinto, Meir G.; Freund, Herbert R.; Grakov, Anna; Nissan, Aviram] Hadassah Hebrew Univ, Med Ctr, Dept Surg, Jerusalem, Israel. [Prus, Diana] Hadassah Hebrew Univ, Med Ctr, Dept Pathol, Jerusalem, Israel. [Shia, Jinru] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Peretz, Tamar] Hadassah Hebrew Univ, Med Ctr, Dept Oncol, Jerusalem, Israel. RP Nissan, A (reprint author), Hadassah Univ Hosp Mt Scopus, Dept Surg, POB 24035, IL-91240 Jerusalem, Israel. EM anissan@hadassah.org.il OI Shia, Jinru/0000-0002-4351-2511 NR 49 TC 8 Z9 9 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD APR 1 PY 2008 VL 97 IS 5 BP 416 EP 422 DI 10.1002/jso.20989 PG 7 WC Oncology; Surgery SC Oncology; Surgery GA 284RH UT WOS:000254723000012 PM 18286523 ER PT J AU Yeo, HS AF Yeo, Hyeonsoo TI Assessment of active controls for rotor performance enhancement SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 62nd Annual Forum of the American-Helicopter-Society CY MAY 09-11, 2006 CL Phoenix, AZ ID TRAILING-EDGE FLAPS; HELICOPTER AB A study was conducted to assess the capability of active controls to produce rotor performance improvements. The calculations were conducted using the comprehensive analysis CAMRAD II. The baseline rotor considered was a four-bladed articulated rotor with a VR-12 airfoil. Seven active control concepts were investigated: leading edge slat, variable droop leading edge, oscillatory jet, Gurney flap, individual blade control, active twist, and trailing edge flap. Comparative performance calculations have been conducted for two cases: (1) an airspeed sweep at C-T/sigma = 0.075 to examine rotor lift-to-drag ratio and (2) thrust sweeps at fixed airspeeds to estimate maximum blade loading capability. The individual blade control, active twist, and trailing edge flap concepts improved the rotor lift-to-drag ratio with a 2/rev harmonic control. The remaining four concepts-leading edge slat, variable droop leading edge, oscillatory jet, and Gurney flap-increased the blade maximum loading capability when these devices were used over the retreating side of the rotor disk. C1 US Army Res Dev & Engn Command, Ames Res Ctr, Aeroflightdynam Directorate, Moffett Field, CA USA. RP Yeo, HS (reprint author), US Army Res Dev & Engn Command, Ames Res Ctr, Aeroflightdynam Directorate, Moffett Field, CA USA. EM hsyeo@mail.arc.nasa.gov NR 31 TC 22 Z9 25 U1 0 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2008 VL 53 IS 2 BP 152 EP 163 PG 12 WC Engineering, Aerospace SC Engineering GA 288SS UT WOS:000255006700004 ER PT J AU Masarati, P Piatak, DJ Quaranta, G Singleton, JD Shen, JW AF Masarati, Pierangelo Piatak, David J. Quaranta, Giuseppe Singleton, Jeffrey D. Shen, Jinwei TI Soft-inplane tiltrotor aeromechanics investigation using two comprehensive multibody solvers SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID SYSTEMS; ROTORCRAFT; STABILITY; MODEL AB This paper focuses on the development of multibody numerical models to predict the dynamic response, aeroelastic stability, and blade loading of a soft-inplane tiltrotor wind-tunnel model. Comprehensive rotorcraft-based multibody analyses enable modeling of the rotor system to a high level of detail such that complex mechanics and nonlinear effects associated with control system geometry, and joint deadband may be considered. The influence of these and other nonlinear effects on the aeromechanical behavior of the tiltrotor model is examined. To assess the reliability of the multibody approach to rotorcraft analysis, the results obtained using two different rotorcraft-based multibody solvers are analyzed and compared. A parametric study of some design parameters that may influence the aeromechanics of the soft-inplane rotor system is also included in this investigation. C1 [Masarati, Pierangelo; Quaranta, Giuseppe] Politecn Milan, Dipartimento Ingn Aerospaziale, I-20133 Milan, Italy. [Piatak, David J.] NASA, Langley Res Ctr, Aeroelast Branch, Hampton, VA 23665 USA. [Singleton, Jeffrey D.] Army Res Labs, Vehicle Technol Directorate, Hampton, VA USA. [Shen, Jinwei] Natl Inst Aerosp, Hampton, VA USA. RP Quaranta, G (reprint author), Politecn Milan, Dipartimento Ingn Aerospaziale, I-20133 Milan, Italy. EM quaranta@aero.polimi.it RI Masarati, Pierangelo/I-3898-2012; Quaranta, Giuseppe/F-7955-2012 OI Masarati, Pierangelo/0000-0002-9347-7654; Quaranta, Giuseppe/0000-0002-8873-7351 NR 33 TC 7 Z9 7 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2008 VL 53 IS 2 BP 179 EP 192 DI 10.4050/JAHS.53.179 PG 14 WC Engineering, Aerospace SC Engineering GA 288SS UT WOS:000255006700006 ER PT J AU Yeo, HS Johnson, W AF Yeo, Hyeonsoo Johnson, Wayne TI Prediction of rotor structural loads with comprehensive analysis SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 31st European Rotorcraft Forum CY SEP 13-15, 2005 CL Florence, ITALY ID HELICOPTER AB Blade flap and chord bending and torsion moments are investigated for five rotors operating at transition and high speed: H-34 in flight and wind tunnel, SA 330 (research Puma), SA 349/2, UH-60A full-scale, and BO-105 model (HART-I). The measured data from flight and wind tunnel tests are compared with calculations obtained using the comprehensive analysis CAMRAD II. The calculations were made using two free wake models: rolled-up and multiple-trailer with consolidation models. At transition speed, there is fair to good agreement for the flap and chord bending moments between the test data and analysis for the H-34, research Puma, and SA 349/2. Torsion moment correlation, in general, is fair to good for all the rotors investigated. Better flap bending and torsion moment correlation is obtained for the UH-60A and BO-105 rotors by using the multiple-trailer with consolidation wake model. In the high-speed condition, the analysis shows generally better correlation in magnitude than in phase for the flap bending and torsion moments. However, a significant underprediction of chord bending moment is observed for the research Puma and UH-60A. The poor correlation of the chord bending moment for the UH-60A appears to be caused by both the airloads model (at all radial locations) and the lag damper model (mostly at inboard locations). C1 [Yeo, Hyeonsoo] USA, Aeroflightdynam Directorate, Res Dev & Engn Command, Ames Res Ctr, Moffett Field, CA USA. [Johnson, Wayne] NASA, Ames Res Ctr, Aeromech Branch, Moffett Field, CA 94035 USA. RP Yeo, HS (reprint author), USA, Aeroflightdynam Directorate, Res Dev & Engn Command, Ames Res Ctr, Moffett Field, CA USA. EM hsyeo@mail.arc.nasa.gov NR 13 TC 21 Z9 22 U1 0 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2008 VL 53 IS 2 BP 193 EP 209 PG 17 WC Engineering, Aerospace SC Engineering GA 288SS UT WOS:000255006700007 ER PT J AU Convertino, VA Ryan, KL Rickards, CA Salinas, J McManus, JG Cooke, WH Holcomb, JB AF Convertino, Victor A. Ryan, Kathy L. Rickards, Caroline A. Salinas, Jose McManus, John G. Cooke, William H. Holcomb, John B. TI Physiological and medical monitoring for en route care of combat casualties SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Advanced Technology Applications in Combat Casualty Care Conference (ATACCC) CY AUG, 2006 CL St Petersburg, FL DE closed-loop fluid resuscitation; closed-loop oxygen delivery; hypovolemia; arterial blood pressure; pulse pressure; heart period variability ID HEART-RATE-VARIABILITY; TRAUMATIC SHOCK RESUSCITATION; OXYGEN-SATURATION PREDICTS; BODY NEGATIVE-PRESSURE; 110 MM HG; HEMORRHAGIC-SHOCK; CENTRAL HYPOVOLEMIA; LIFESAVING INTERVENTIONS; REDEFINING HYPOTENSION; ORGAN DYSFUNCTION AB Background. most prehospital medical interventions during civilian and military trauma casualty transport fail to utilize advanced decision-support systems for treatment and delivery of medical interventions, particularly intravenous fluids and oxygen. Current treatment protocols are usually based on standard vital signs (eg, blood pressure, arterial oxygen saturation) which have proven to be of limited value in detecting the need to implement an intervention before cardiovascular collapse. A primary objective of the US Army combat casualty care research program is to reduce mortality and morbidity during casualty transport from the battlefield through advanced development of a semiautomated decision-support capability for closed-loop resuscitation and oxygen delivery. Methods: To accomplish this goal, the Trauma Informatics Research Team at the US Army Institute of Surgical Research has developed two models for evidence-based decision support 1) a trauma patient database for capture and analysis of prehospital vital signs for identification of early, novel physiologic measurements that could improve the control of closed-loop systems in trauma patients; and, 2) a human experimental model of central hypovolemia using lower body negative pressure to improve the understanding and identification of physiologic signals for advancing closed-loop capabilities with simulated hemodynamic responses to hemorrhage. Results: In the trauma patient database and lower body negative pressure studies, traditional vital sign measurements such as systolic blood pressure and oxygen saturation fail to predict mortality or indicate the need for life saving interventions or reductions in central blood volume until after the onset of cardiovascular collapse. We have evidence from preliminary analyses, however, that indicators of reduced central blood volume in the presence of stable vital signs include 1) reductions in pulse pressure; 2) changes in indices of autonomic balance derived from calculation of heart period variability (ie, linear and non-linear analyses of R-R intervals); and 3) reductions in tissue oxygenation. Conclusions: We propose that derived indices based on currently available technology for continuous monitoring of specific hemodynamic, autonomic, and/or metabolic responses could provide earlier recognition of hemorrhage than current standard vital signs and allow intervention before the onset of circulatory shock. Because of this, such indices could provide improved feedback for closed-loop control of patient resuscitation and oxygen delivery. These technological, advances could prove instrumental in advancing decision-support capabilities for prehospital trauma care during transport to higher levels of care in both the military and civilian environments. C1 [Convertino, Victor A.; Ryan, Kathy L.; Rickards, Caroline A.; Salinas, Jose; McManus, John G.; Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cooke, William H.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, Bldg 3611,3400 Rawley E Chembers Ave, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil NR 45 TC 66 Z9 66 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2008 VL 64 IS 4 SU S BP S342 EP S353 DI 10.1097/TA.0b013e31816c82f4 PG 12 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 288WT UT WOS:000255017400007 PM 18385586 ER PT J AU Kramer, GC Kinsky, MP Prough, DS Salinas, J Sondeen, JL Hazel-Scerbo, ML Mitchell, CE AF Kramer, George C. Kinsky, Michael P. Prough, Donald S. Salinas, Jose Sondeen, Jill L. Hazel-Scerbo, Michelle L. Mitchell, Charles E. TI Closed-loop control of fluid therapy for treatment of hypovolemia SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE fluid resuscitation; circulatory shock; combat casualty care; autonomous healthcare; trauma ID LACTATED RINGERS SOLUTION; INFRARED SPECTROSCOPY IDENTIFY; HYPOTENSIVE RESUSCITATION; HYPERTONIC-SALINE; HEMORRHAGE MODEL; MULTIPLE HEMORRHAGES; HYDROXYETHYL STARCH; SWINE HEMORRHAGE; TRAUMA PATIENTS; CARDIAC-OUTPUT AB Closed-loop algorithms and resuscitation systems are being developed to control IV infusion rate during early resuscitation of hypovolemia. Although several different physiologic variables have been suggested as an endpoint to guide fluid therapy, blood pressure remains the most used variable for the initial assessment of hemorrhagic shock and the treatment response to volume loading. Closed-loop algorithms use a controller function to alter infusion rate inversely to blood pressure. Studies in hemorrhaged conscious sheep suggest that: (1) a small reduction in target blood pressure can result in a significant reduction in volume requirement; (2) nonlinear algorithms may reduce the risk of increased internal bleeding during resuscitation; (3) algorithm control functions based on proportional-integral, fuzzy logic, or nonlinear decision tables were found to restore and maintain blood pressure equally well. Proportional-integral and fuzzy logic algorithms reduced mean fluid volume requirements compared with the nonlinear decision table; and (4) several algorithms have been constructed to the specific mechanism of injury and the volume expansion properties of different fluids. Closed-loop systems are undergoing translation from animal to patient studies. Future smart resuscitation systems will benefit from new noninvasive technologies for monitoring blood pressure and the development of computer controlled high flow intravenous pumps. C1 [Kramer, George C.; Kinsky, Michael P.; Prough, Donald S.; Hazel-Scerbo, Michelle L.; Mitchell, Charles E.] Univ Texas Galveston, Med Branch, Dept Anesthesiol, Resuscitat Res Lab, Galveston, TX 77555 USA. [Salinas, Jose; Sondeen, Jill L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kramer, GC (reprint author), Univ Texas Galveston, Med Branch, Dept Anesthesiol, Resuscitat Res Lab, 301 Univ Blvd, Galveston, TX 77555 USA. EM gkramer@utmb.edu RI Prough, Donald/G-5793-2013 OI Prough, Donald/0000-0001-7994-532X NR 43 TC 17 Z9 18 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-5282 EI 1529-8809 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2008 VL 64 IS 4 SU S BP S333 EP S341 DI 10.1097/TA.0b013e31816bf517 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 288WT UT WOS:000255017400006 PM 18385585 ER PT J AU Pauldine, R Beck, G Salinas, J Kaczka, DW AF Pauldine, Ronald Beck, George Salinas, Jose Kaczka, David W. TI Closed-loop strategies for patient care systems SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE closed-loop; critical care medicine; mass casualty ID CRITICALLY ILL PATIENTS; BISPECTRAL INDEX; MECHANICAL VENTILATION; INTRAHOSPITAL TRANSPORT; FUZZY-LOGIC; INTRAVENOUS ANESTHESIA; SODIUM-NITROPRUSSIDE; PROPOFOL ANESTHESIA; SECONDARY INSULTS; DECISION TABLES AB Military operations, mass casualty events, and remote work sites present unique challenges to providers of immediate medical care, who may lack the necessary skills for optimal clinical management Moreover, the number of patients in these scenarios may overwhelm available health care resources. Recent applications of closed-loop control (CLC) techniques to critical care medicine may offer possible solutions for such environments. Here, feedback of a monitored variable or group of variables is used to control the state or output of a dynamic system. Some potential advantages of CLC in patient management include limiting task saturation when there is simultaneous demand for cognitive and active clinical intervention, improving quality of care through optimization of the titration of medications, conserving limited consumable supplies, preventing secondary insults in traumatic brain injury, shortening the duration of mechanical ventilation, and achieving appropriate goal-directed resuscitation. The uses of CLC systems in critical care medicine have been increasingly explored across a wide range of therapeutic modalities. This review will provide an overview of control system theory as applied to critical care medicine that must be considered in the design of autonomous CLC systems, and introduce a number of clinical applications under development in the context of deployment of such applications to austere environments. C1 [Pauldine, Ronald] Johns Hopkins Bayview Med Ctr, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21218 USA. [Beck, George] Impact Instrumentat Inc, W Caldwell, NJ USA. [Salinas, Jose] USA, Inst Surg Res, Trauma Informat Syst Dev, Ft Sam Houston, TX 78234 USA. [Kaczka, David W.] Johns Hopkins Univ, Dept Biomed Engn, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. RP Pauldine, R (reprint author), Johns Hopkins Bayview Med Ctr, Dept Anesthesiol & Crit Care Med, A3W-387, Baltimore, MD 21218 USA. EM rpauldi1@jhmi.edu OI Kaczka, David/0000-0003-4378-5242 NR 60 TC 9 Z9 11 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2008 VL 64 IS 4 SU S BP S289 EP S294 DI 10.1097/TA.0b013e31816bce43 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 288WT UT WOS:000255017400002 PM 18385581 ER PT J AU Salinas, J Drew, G Gallagher, J Cancio, LC Wolf, SE Wade, CE Holcomb, JB Herndon, DN Kramer, GC AF Salinas, Jose Drew, Guy Gallagher, James Cancio, Leopoldo C. Wolf, Steven E. Wade, Charles E. Holcomb, John B. Herndon, David N. Kramer, George C. TI Closed-loop and decision-assist resuscitation of burn patients SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE closed-loop; critical care; decision-assist; resuscitation; burns ID MICROVASCULAR EXCHANGE; PULMONARY-EDEMA; CONSCIOUS SHEEP; INJURY; PRESSURE; MEDICINE; CHILDREN; MODEL; SHOCK; CARE AB Effective resuscitation is critical in reducing mortality and morbidity rates of patients with acute burns. To this end, guidelines and formulas have been developed to define infusion rates and volume requirements during the first 48 hours postburn. Even with these standardized resuscitation guidelines, however, over-and under-resuscitation are not uncommon. Two approaches to adjust infusion rate are decision-assist and closed-loop algorithms based on levels of urinary output. Specific decision assist guidelines or a closed-loop system using computer-controlled feedback technology that supplies automatic control of infusion rates can potentially achieve better control of urinary output. In a properly designed system, closed-loop control has the potential to provide more accurate titration rates, while lowering the incidence of over- and under-resuscitation. Because the system can self-adjust based on monitoring inputs, the technology can be pushed to environments such as combat zones where burn resuscitation expertise is limited. A closed-loop system can also assist in the management of mass casualties, another scenario in which medical expertise is often in short supply. This article reviews the record of fluid balance of contemporary burn resuscitation and approaches, as well as the engineering efforts, animal studies, and algorithm development of our most recent autonomous systems for burn resuscitation. C1 [Salinas, Jose; Drew, Guy; Cancio, Leopoldo C.; Wolf, Steven E.; Wade, Charles E.; Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kramer, George C.] Univ Texas Galveston, Med Branch, Dept Anesthesiol, Galveston, TX 77550 USA. [Gallagher, James] Univ Texas Galveston, Med Branch, Dept Surg, Galveston, TX 77550 USA. RP Salinas, J (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM jose.salinas@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 47 TC 25 Z9 27 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2008 VL 64 IS 4 SU S BP S321 EP S332 DI 10.1097/TA.0b013e31816bf4f7 PG 12 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 288WT UT WOS:000255017400005 PM 18385584 ER PT J AU Arthurs, ZM Andersen, C Starnes, BW Sohn, VY Mullenix, PS Perry, J AF Arthurs, Zachary M. Andersen, Charles Starnes, Benjamin W. Sohn, Vance Y. Mullenix, Philip S. Perry, Jason TI A prospective evaluation of C-reactive protein in the progression of carotid artery stenosis SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 22nd Annual Meeting of the Western-Vascular-Society CY SEP 08-11, 2007 CL Kona, HI SP Western Vasc Soc ID CARDIOVASCULAR-DISEASE; STATIN THERAPY; NATURAL-HISTORY; ISCHEMIC-STROKE; INFLAMMATION; RISK; CORONARY; MARKERS; PLAQUE; ATHEROSCLEROSIS AB Objective: Our institution previously reported an association between elevated C-reactive protein (CRP) and carotid artery stenosis. Based on this finding, we sought to further evaluate the association of CRP levels with ultrasound progression of carotid artery stenosis, and/or clinical events. Metbods. A prospective observational study of patients evaluated for carotid artery stenosis was performed at a tertiary medical center from 2003-2007. Patients underwent serial lab draws for serum CRP, as well as serial duplex ultrasounds of their carotid bifurcations. Examinations were performed at 6-month intervals. Initial risk factors and CRP levels were evaluated with univariate statistics. Ultrasound progression of disease was evaluated with Kaplan-Meier curves and Cox regression analysis. Results. During the study period, 271 patients completed study requirements with a mean follow-up of 37 (+/- 6) months. Initial duplex examination revealed 114 (41%) of patients had 0% to 15%, 94 (35%) had 16% to 49%, and 63 (23%) had 50% to 79% stenosis of the carotid bifurcation. Sixty-three patients (23%) demonstrated progression of disease by ultrasound examination, 27 (10%) progressed to carotid endarterectomy, and three (1%) experienced a stroke during follow-up. Mean CRP levels were higher among patients that progressed on duplex examination (6.7 +/- 1.28 vs 4.6 +/- 0.4 mg/dl, P < .05). Kaplan-Meier analysis revealed a significant difference in freedom from progression of carotid artery disease for patients with I-st and 3(rd) quartile CRP levels (log-rank test P < .05). Adjusting for diabetes, hyperlipidemia, hypertension, coronary artery disease, aspirin or other anti-inflammatory uses, and statin therapy, 4(th) quartile CRP was independently associated with disease progression (OR 1.8, 95% CI; 1.03-2.99, P < .05). Conclusions: High CRP levels predict ultrasound progression of disease in patients with carotid artery stenosis. In addition, CRP levels may provide additional information to help guide idtimate therapy for evaluation and follow-up of patients with borderline lesions identified by duplex exam. C1 [Arthurs, Zachary M.; Andersen, Charles; Sohn, Vance Y.; Perry, Jason] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Starnes, Benjamin W.] Univ Washington, Seattle, WA 98195 USA. [Mullenix, Philip S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Arthurs, ZM (reprint author), Madigan Army Med Ctr, Dept Surg, 3032 Ridge View Pl, Dupont, WA 98327 USA. EM arthursz@mac.com NR 28 TC 17 Z9 17 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD APR PY 2008 VL 47 IS 4 BP 744 EP 750 DI 10.1016/j.jvs.2007.11.066 PG 7 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 282BP UT WOS:000254542900010 PM 18308505 ER PT J AU Boonnak, K Slike, BM Burgess, TH Mason, RM Wu, SJ Sun, P Porter, K Rudiman, IF Yuwono, D Puthavathana, P Marovich, MA AF Boonnak, Kobporn Slike, Bonnie M. Burgess, Timothy H. Mason, Randall M. Wu, Shuenn-Jue Sun, Peifang Porter, Kevin Rudiman, Irani Fianza Yuwono, Djoko Puthavathana, Pilaipan Marovich, Mary A. TI Role of dendritic cells in antibody-dependent enhancement of dengue virus infection SO JOURNAL OF VIROLOGY LA English DT Article ID ROSS RIVER VIRUS; HEMORRHAGIC-FEVER; NEUTRALIZING ANTIBODIES; CYTOKINE PRODUCTION; SHOCK SYNDROME; FC-RECEPTORS; RISK-FACTOR; SEVERITY; EXPRESSION; DISEASE AB Dengue viruses (DV), composed of four distinct serotypes (DV1 to DV4), cause 50 to 100 million infections annually. Durable homotypic immunity follows infection but may predispose to severe subsequent heterotypic infections, a risk conferred in part by the immune response itself. Antibody-dependent enhancement (ADE), a process best described in vitro, is epidemiologically linked to complicated DV infections, especially in Southeast Asia. Here we report for the first time the ADE phenomenon in primary human dendritic cells (DC), early targets of DV infection, and human cell lines bearing Fc receptors. We show that ADE is inversely correlated with surface expression of DC-SIGN (DC-specific intercellular adhesion molecule-3-grabbing nonintegrin) and requires Fc gamma receptor IIa (Fc gamma RIIa). Mature DC exhibited ADE, whereas immature DC, expressing higher levels of DC-SIGN and similar Fc gamma RIIa levels, did not undergo ADE. ADE results in increased intracellular de novo DV protein synthesis, increased viral RNA production and release, and increased infectivity of the supernatants in mature DC. Interestingly, tumor necrosis factor alpha and interleukin-6 (IL-6), but not IL-10 and gamma interferon, were released in the presence of dengue patient sera but generally only at enhancement titers, suggesting a signaling component of ADE. Fc gamma RIIa inhibition with monoclonal antibodies abrogated ADE and associated downstream consequences. DV versatility in entry routes (Fc gamma RIIa or DC-SIGN) in mature DC broadens target options and suggests additional ways for DC to contribute to the pathogenesis of severe DV infection. Studying the cellular targets of DV infection and their susceptibility to ADE will aid our understanding of complex disease and contribute to the field of vaccine development. C1 [Boonnak, Kobporn; Slike, Bonnie M.; Mason, Randall M.; Marovich, Mary A.] Univ Hlth Sci, Walter Reed Army Inst Res, Div Retrovirol,Dept Med, Dept Vaccine R&D,Uniformed Serv, Rockville, MD 20850 USA. [Boonnak, Kobporn; Slike, Bonnie M.; Mason, Randall M.; Marovich, Mary A.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA. [Burgess, Timothy H.; Sun, Peifang; Porter, Kevin] USN, Med Res Ctr, Dept Virus Dis, Bethesda, MD 20889 USA. [Wu, Shuenn-Jue] Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD 20889 USA. [Rudiman, Irani Fianza] Hasan Sadikin Hosp, Dept Internal Med, Bandung, Indonesia. [Yuwono, Djoko] Indonesian Ministry Hlth, Natl Inst Hlth Res & Dev, Jakarta, Indonesia. [Boonnak, Kobporn; Puthavathana, Pilaipan] Mahidol Univ, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand. [Marovich, Mary A.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Marovich, MA (reprint author), Univ Hlth Sci, Walter Reed Army Inst Res, Div Retrovirol,Dept Med, Dept Vaccine R&D,Uniformed Serv, 13 Taft Ct,Suite 200, Rockville, MD 20850 USA. EM mmarovich@hivresearch.org RI Porter, Kevin/A-8027-2011 NR 52 TC 100 Z9 111 U1 1 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD APR PY 2008 VL 82 IS 8 BP 3939 EP 3951 DI 10.1128/JVI.02484-07 PG 13 WC Virology SC Virology GA 284QQ UT WOS:000254721300014 PM 18272578 ER PT J AU Le Fer, D Fraser, JD Kruse, CD AF Le Fer, Danielle Fraser, James D. Kruse, Casey D. TI Piping plover chick foraging, growth, and survival in the Great Plains SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article DE Charadrius melodus; foraging; Great Plains; growth; habitat; hypolimnetic; invertebrates; Missouri River; piping plover; survival ID RIVER AB We tested the hypothesis that piping plover (Charadrius melodus) habitat quality and chick survival on the Missouri River, USA, were lower on a cold-water reservoir and downstream from a hypolimnetic (cold-water) release dam with diel water fluctuations (Garrison Dam) than downstream from an epilimnetic dam (Gavins Point Dam). Plovers in adjacent alkali wetlands provided an index to the maximum reproductive potential in the region. Chicks gained weight more rapidly in the alkali wetlands than on epilimnetic and hypolimnetic river reaches. Invertebrate numbers and biomass were higher in the wetlands and epilimnetic reach, but chick survival was lower on the epilimnetic reach. Thus, piping plovers adapted to a variety of prey densities, and other factors, likely predation, reduced survival rates in the epilimnetic reach. Temporal and spatial variability in site quality indices suggests the need for a regional management strategy with different strategies at each site. Managers can minimize effects of local fluctuations in resource abundance and predators by ensuring protection of or creating geographically dispersed habitat. C1 [Le Fer, Danielle; Fraser, James D.] Virginia Tech, Dept Fisheries & Wildlife, Blacksburg, VA 24060 USA. [Kruse, Casey D.] US Army Corps Engineers, Yankton, SD 57078 USA. RP Le Fer, D (reprint author), Virginia Tech, Dept Fisheries & Wildlife, Blacksburg, VA 24060 USA. EM dlefer@sjbbo.org NR 32 TC 15 Z9 16 U1 2 U2 8 PU WILDLIFE SOC PI BETHESDA PA 5410 GROSVENOR LANE, BETHESDA, MD 20814-2197 USA SN 0022-541X J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD APR PY 2008 VL 72 IS 3 BP 682 EP 687 DI 10.2193/2007-097 PG 6 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 280GD UT WOS:000254412800014 ER PT J AU Wang, Y Djie, HS Ooi, BS Hwang, JCM Fang, XM Wu, Y Fastenau, JM Liu, WK Dang, GT Chang, WH AF Wang, Y. Djie, H. S. Ooi, B. S. Hwang, J. C. M. Fang, X. -M. Wu, Y. Fastenau, J. M. Liu, W. K. Dang, G. T. Chang, W. H. TI Monolithic InAs/InAlGaAs/InP quantum-dash-in-well extended-cavity laser fabricated by postgrowth intermixing SO LASER PHYSICS LA English DT Article AB The first demonstration of a monolithic integrated extended-cavity laser in an InAs/InAlGaAs quantum-dash-in-well structure on an InP substrate is reported. The integration is achieved using nitrogen implantation-induced quantum-dash intermixing. A differential blue shift of 128 nm has been obtained between the active and intermixed passive sections. A propagation loss of 9.2 cm(-1) within the intermixed passive waveguide section has been measured by comparing laser threshold currents of all active and integrated extended passive cavity devices. C1 [Wang, Y.; Djie, H. S.; Ooi, B. S.; Hwang, J. C. M.] Lehigh Univ, Ctr Opt Technol, Bethlehem, PA 18015 USA. [Wang, Y.; Djie, H. S.; Ooi, B. S.; Hwang, J. C. M.] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. [Fang, X. -M.; Wu, Y.; Fastenau, J. M.; Liu, W. K.] IQE Inc, Bethlehem, PA 18015 USA. [Dang, G. T.; Chang, W. H.] Army Res Lab, Adelphi, MD 20783 USA. [Djie, H. S.] JDS Uniphase Corp, San Jose, CA 95134 USA. RP Wang, Y (reprint author), Lehigh Univ, Ctr Opt Technol, Bethlehem, PA 18015 USA. EM yaw2@lehigh.edu; bsooi@lehigh.edu RI Ooi, Boon/D-4370-2011 OI Ooi, Boon/0000-0001-9606-5578 NR 7 TC 0 Z9 0 U1 0 U2 1 PU MAIK NAUKA/INTERPERIODICA/SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 1054-660X J9 LASER PHYS JI Laser Phys. PD APR PY 2008 VL 18 IS 4 BP 400 EP 402 DI 10.1134/S1054660X08040075 PG 3 WC Optics; Physics, Applied SC Optics; Physics GA 290LL UT WOS:000255124200007 ER PT J AU Hope, RJ Weber, ED Bower, KS Pasternak, JP Sliney, DH AF Hope, R. J. Weber, E. D. Bower, K. S. Pasternak, J. P. Sliney, D. H. TI Scattered UV irradiation during VISX excimer laser keratorefractive surgery SO LASERS IN SURGERY AND MEDICINE LA English DT Article; Proceedings Paper CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology CY APR 30-MAY 04, 2006 CL Ft Lauderdale, FL SP Assoc Res Vis & Ophthalmol DE excimer laser; corneal refractive surgery; exposure risk; safety ID RADIATION AB Purpose: To evaluate the potential occupational health hazards associated with scattered ultraviolet (UV) radiation during photorefractive keratectomy (PRK) using the VISX Star S3 excimer laser. Setting: The Laser Vision Center, National Naval Medical Center, Bethesda, Maryland, USA. Methods: Intraoperative radiometric measurements were made with the Ophir Power/Energy Meter (LaserStar Model PD-10 with silicon detector) during PRK treatments as well as during required calibration procedures at a distance of 20.3 cm from the left cornea. These measurements were evaluated using a worst-case scenario for exposure, and then compared with the American Conference of Governmental Industrial Hygeinists (ACGIH) Threshold Value Limits (TVL) to perform a risk/hazard analysis. Results: During the PRK procedures, the highest measured value was 248.4 nJ/pulse. During the calibration procedures, the highest measured UV scattered radiation level was 149.6 nJ/pulse. The maximum treatment time was 52 seconds. Using a worst-case scenario in which all treatments used the maximum power and time, the total energy per eye treated was 0.132 mJ/cm(2) and the total UV radiation at close range (80 cm from the treated eye) was 0.0085 mJ/cm(2). With a workload of 20 patients, the total occupational exposure at 80 cm to actinic UV radiation in an 8-hour period would be 0.425 mJ/cm(2). Conclusions: The scattered actinic UV laser radiation from the VISX Star S3 excimer laser did not exceed occupational exposure limits during a busy 8-hour workday, provided that operating room personnel were at least 80 cm from the treated eye. While the use of protective eyewear is always prudent, this study demonstrates that the trace amounts of scattered laser emissions produced by this laser do not pose a serious health risk even without the use of protective eyewear. C1 [Hope, R. J.; Weber, E. D.; Bower, K. S.] Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Washington, DC 20307 USA. [Pasternak, J. P.] Natl Naval Med Ctr, Ophthalmol Serv, Bethesda, MD USA. [Sliney, D. H.] USA, Laser Opt Radiat Program, Ctr Hlth Promot & Preventat Med, Aberdeen Proving Ground, MD USA. RP Bower, KS (reprint author), Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Room 2F-205,6900 Georgia Ave NW, Washington, DC 20307 USA. EM kraig.bower@na.amedd.army.mil NR 4 TC 1 Z9 1 U1 0 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0196-8092 J9 LASER SURG MED JI Lasers Surg. Med. PD APR PY 2008 VL 40 IS 4 BP 243 EP 246 DI 10.1002/lsm.20627 PG 4 WC Dermatology; Surgery SC Dermatology; Surgery GA 296AD UT WOS:000255515000004 PM 18412228 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI All hands down: The true story of the Soviet attack the USS scorpion SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 2008 VL 133 IS 6 BP 94 EP 94 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 285XY UT WOS:000254810700179 ER PT J AU Mascia, NT Santana, CLDO Cramer, SM AF Mascia, Nilson Tadeu de Oliveira Santana, Claudia Lucia Cramer, Steven M. TI Evaluation of the Equivalent Slip Modulus of Nailed Connections for Application in Linear Analysis of Plywood Timber Beams SO MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS LA English DT Article DE semirigid connections; stiffness; nails; plywood-timber beams ID WOOD AB The study of the stiffness of laterally loaded semi-rigid connections in plywood-timber beams is justified by the influence that the deformation of the connection has on the overall displacements of the structure. Semi-rigid connections are characterized by the occurrence of a slip between the connected pieces. The characterization of a connection is usually based on an isolated single connector behavior, which is described by its load-slip relationship expressed by the slip modulus, and so it is extended to the group of connectors. Although the method of analysis is well established, the concept of equivalent slip modulus, defined as the slip modulus per unit length of a connection, has not been totally explored. In this study, we focus on the experimental determination of the equivalent slip modulus for mechanically analyzing plywood-timber beams with continuous connections. The results demonstrated that the test is suitable for obtaining experimental values of the equivalent slip modulus. C1 [Mascia, Nilson Tadeu; de Oliveira Santana, Claudia Lucia] State Univ Campinas UNICAMP, Sch Civil Engn Architecture & Urbanism, BR-13083852 Campinas, SP, Brazil. [Cramer, Steven M.] Univ Wisconsin, USA, Madison, WI 53706 USA. RP Mascia, NT (reprint author), State Univ Campinas UNICAMP, Sch Civil Engn Architecture & Urbanism, CP 6021, BR-13083852 Campinas, SP, Brazil. EM nilson@fec.unicamp.br FU FAPESP [00/00953-8] FX The authors gratefully acknowledge support for the research which originated this work, from FAPESP grant (proc. no 00/00953-8). NR 15 TC 1 Z9 1 U1 1 U2 2 PU UNIV FED SAO CARLOS, DEPT ENGENHARIA MATERIALS PI SAO CARLOS PA LABORATORIA DE MATERIAIS VITREOS, CAIXA POSTAL 676, SAO CARLOS, 13565-905SP, BRAZIL SN 1516-1439 J9 MATER RES-IBERO-AM J JI Mater. Res.-Ibero-am. J. Mater. PD APR-JUN PY 2008 VL 11 IS 2 BP 151 EP 157 DI 10.1590/S1516-14392008000200007 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA 364YH UT WOS:000260371200007 ER PT J AU Berry-Caban, CS Lynch, S AF Berry-Caban, Cristobal S. Lynch, Steven TI Soldiers' experience with medical hold: The case of fort bragg SO MILITARY MEDICINE LA English DT Article ID PATIENT SATISFACTION; MILITARY MEDICINE; MODEL; CARE AB Soldiers' treatment in medical hold has been controversial due in part to a series of articles that appeared in the popular press. The purpose of this study was to explore soldiers' satisfaction as an indicator of the quality of health and treatment care received while in medical hold at Womack Army Medical Center (Fort Bragg, North Carolina). Data came from a survey of 17 questions that was administered on a point prevalence date and analyzed using descriptive statistics. A total of 47 of 164 soldiers on medical hold on March 1, 2007 responded. The overall patient satisfaction averaged 81.57%, based on a 5-point Likert rating scale for the soldier case sample. However, the survey also showed areas where Womack can improve. C1 [Berry-Caban, Cristobal S.] Womack Army Med Ctr, Informat Management Div, Ft Bragg, NC 28310 USA. [Lynch, Steven] Womack Army Med Ctr, Dept Family Med, Ft Bragg, NC 28310 USA. RP Berry-Caban, CS (reprint author), Womack Army Med Ctr, Informat Management Div, Ft Bragg, NC 28310 USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2008 VL 173 IS 4 BP 349 EP 352 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 288CL UT WOS:000254963700006 PM 18472623 ER PT J AU Lacy, BW Ditzler, TF Wilson, RS Martin, TM Ochikubo, JT Roussel, RR Pizarro-Matos, JM Vazquez, R AF Lacy, Benjamin W. Ditzler, Thomas F. Wilson, Raymond S. Martin, Thomas M. Ochikubo, Jon T. Roussel, Robert R. Pizarro-Matos, Jose M. Vazquez, Raymond TI Regional methamphetamine use among US Army personnel stationed in the continental United States and Hawaii: A six-year retrospective study (2000-2005) SO MILITARY MEDICINE LA English DT Article ID DRUG; ABUSE; MILITARY AB Substance use disorders constitute a serious and persistent threat to military readiness and to the health and safety of military personnel and their families. Methamphetamine is among the most addictive and damaging of commonly abused drugs; this is of great concern for military health providers in Hawaii due to the unusually high prevalence in the local community. The effect of regional drug use on active duty subpopulations has not been previously studied. This study includes a 6-year retrospective sample of laboratory-confirmed methamphetamine-, cocaine-, and marijuana-positive drug tests among Army soldiers stationed in Hawaii and western and eastern continental U.S. installations. The findings suggest that active duty members are significantly affected by the local drug climate. However, current military drug policies also deter use as evidenced by low absolute drug-positive rates even in regions of high civilian prevalence. C1 [Lacy, Benjamin W.; Ditzler, Thomas F.; Wilson, Raymond S.] ATTN MCHKS PS, Honolulu, HI 96859 USA. [Martin, Thomas M.] FTDTL, Honolulu, HI 96859 USA. [Ochikubo, Jon T.] Tripler Army Med Ctr, ATTN MCHK FT, Tripler Forens Toxicol Drug Testing Lab, Honolulu, HI 96859 USA. [Roussel, Robert R.] US Army Med Command, Fores Drug Testing, Ft Sam Houston, TX 78234 USA. [Pizarro-Matos, Jose M.] Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. [Vazquez, Raymond] Tripler Army Med Ctr, Div Clin Investgat, Honolulu, HI 96859 USA. RP Lacy, BW (reprint author), ATTN MCHKS PS, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 26 TC 4 Z9 4 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2008 VL 173 IS 4 BP 353 EP 358 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 288CL UT WOS:000254963700007 PM 18472624 ER PT J AU Jones, SB Knapik, JJ Jones, BH AF Jones, Sarah B. Knapik, Joseph J. Jones, Bruce H. TI Seasonal variations in injury rates in US Army ordnance training SO MILITARY MEDICINE LA English DT Article ID I TRAUMA CENTER; RUGBY LEAGUE; WEATHER AB Objectives: This study assessed the effects of seasons and temperature on injury rates during U.S. Army ordnance advanced individual training. Methods: Injury data were collected each week at two clinics serving two geographically separated military training units. Weekly injury rates were calculated as the number of injured soldiers in each battalion (numerator) divided by the total number of soldiers in each battalion (denominator). A two-way analysis of variance examined weekly injury rates according to training unit and season of the year. Correlations between injury rates and average maximal temperatures were also examined. Results: Analysis of variance indicated significant differences in injury rates according to training unit (p = 0.04) and season (p < 0.01) but no significant interaction between unit and season (p = 0.16). Injury rates in the summer were higher than injury rates in the winter or autumn. Coefficients for correlations between weekly injury rates and weekly average maximal temperatures were 0.71 and 0.88 for the two training units. Conclusions: These data support previous work in U.S. Army basic combat training indicating a seasonal effect on injury rates. Higher environmental temperatures were associated with higher injury rates. C1 [Jones, Sarah B.] RTI Int, Res Triangle Pk, NC 27709 USA. [Knapik, Joseph J.; Jones, Bruce H.] US Army Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Jones, SB (reprint author), RTI Int, Res Triangle Pk, NC 27709 USA. NR 9 TC 0 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2008 VL 173 IS 4 BP 362 EP 368 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 288CL UT WOS:000254963700009 PM 18472626 ER PT J AU Millikan, AM Niebuhr, DW Brundage, M Powers, TE Krauss, MR AF Millikan, Amy M. Niebuhr, David W. Brundage, Mary Powers, Timothy E. Krauss, Margot R. TI Retention of mild asthmatics in the Navy (REMAIN): A low-risk approach to giving mild asthmatics an opportunity for military service SO MILITARY MEDICINE LA English DT Article ID CHILDHOOD ASTHMA; POPULATION; SYMPTOMS AB Objective: Rising U.S. asthma prevalence will be reflected in military applicants. We studied retaining mild asthmatics on active duty. Methods: A cohort study at Great Lakes Naval Training Center from 2000 to 2002 compared recruits diagnosed during basic training with mild asthma to matched comparison recruits on outpatient visits, hospitalizations, and discharge through August 2003. Results: A total of 136 asthmatic and 404 control subjects were enrolled. Overall attrition was greater among the asthma cohort (p < 0.01), largely during training. Asthmatics used more health care than controls during training (0.1 vs. 0.004 per person-month). No asthma-related hospitalizations or deaths occurred during the study. Conclusions: Although attrition during recruit training was higher in mild asthmatics, nearly 40% of recruits were retained on active duty without significant risk of hospitalization or excessive outpatient treatment after recruit training. These findings argue for consideration of a trial on active duty for recruits with mild asthma. C1 [Millikan, Amy M.; Niebuhr, David W.; Brundage, Mary; Powers, Timothy E.; Krauss, Margot R.] Walter Reed Army Inst Res, Dept Epidemiol, Silver Spring, MD 20910 USA. RP Millikan, AM (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Niebuhr, David/B-7865-2011 NR 20 TC 5 Z9 5 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2008 VL 173 IS 4 BP 381 EP 387 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 288CL UT WOS:000254963700012 PM 18472629 ER PT J AU Collen, J Carmichael, M Wroblewski, T AF Collen, Jacob Carmichael, Mark Wroblewski, Tanya TI Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: A case report SO MILITARY MEDICINE LA English DT Article ID MANAGEMENT AB Primary mediastinal nonseminomatous germ cell tumors (NSGCT) have a worse prognosis than gonadal germ cell tumors (GCTs). Malignant transformation of teratomatous components of GCT to a somatic malignancy is rare. We present a case of primary mediastinal NSGCT with malignant transformation of a teratoma in an active duty airman who presented with a 12-cm anterior mediastinal mass and vertebral body lesion. Pathology confirmed NSGCT with yolk sac and teratomatous components. Chemotherapy for GCT normalized serum tumor markers with little effect on the mediastinal mass. Incomplete resection of the residual tumor revealed high-grade mixed sarcoma. Serum tumor markers rose 3 months following resection with metastatic disease to bone and liver. Chemotherapy targeting sarcoma induced a partial response, but the patient developed acute myeloid leukemia refractory to chemotherapy. We discuss our approach to management of this complicated patient. C1 [Collen, Jacob; Carmichael, Mark; Wroblewski, Tanya] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Collen, J (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW,Bldg 2, Washington, DC 20307 USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2008 VL 173 IS 4 BP 406 EP 409 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 288CL UT WOS:000254963700017 PM 18472634 ER PT J AU van Landingham, NB Straka, TJ Franklin, RM AF van Landingham, Nathaniel B. Straka, Thomas J. Franklin, Robert M. TI Economic analysis of conservation forestry practices: a south Carolina Lowcountry example SO NATURAL AREAS JOURNAL LA English DT Article DE conservation forestry; financial analysis; hardwood management; longleaf pine; prescribed burning ID LONGLEAF PINE AB The Lowcountry Forest Conservation Project was designed to encourage conservation forestry practices on South Carolina's lower coastal plain. The area has great ecological diversity and need for the type of protections afforded by conservation forestry. The project provided demonstrations of these practices and offered forest owners an estimate of the cost-effectiveness of the techniques. This article reports on a financial analysis of the three main practices: (1) the reintroduction of longleaf pine (Pinus palustris P. Miller) into areas that are now loblolly pine plantations (Pinus taeda L.), (2) more and better use of prescribed fire, and (3) bottomland hardwood management. Longleaf pine reintroduction was accomplished using partial clearcuts of existing pine plantations over several decades. Financial return was shown to be competitive with intensively-managed loblolly pine plantations. Pine straw production played a large role in increasing cash flows. Prescribed burning was shown to "pay for itself" in increased stumpage prices and reduced harvesting costs. A technique to better manage bottomland hardwoods for economic returns was discussed. Conservation forestry practices were shown to be economically-effective means to manage forests while benefiting wildlife, aesthetics, and other ecological values. These techniques can be used to analyze other practices and techniques that are used to protect natural areas. Often they can be shown to "pay their own way". C1 [Straka, Thomas J.] Clemson Univ, Dept Forestry & Nat Resources, Clemson, SC 29634 USA. [Franklin, Robert M.] Clemson Univ, Cooperat Extens Serv, Walterboro, SC 29488 USA. [van Landingham, Nathaniel B.] US Army Corps Engn, Clarks Hill, SC 29821 USA. RP Straka, TJ (reprint author), Clemson Univ, Dept Forestry & Nat Resources, Box 340317, Clemson, SC 29634 USA. EM tstraka@clemson.edu NR 58 TC 0 Z9 0 U1 1 U2 9 PU NATURAL AREAS ASSOC PI ROCKFORD PA 320 SOUTH THIRD ST, ROCKFORD, IL 61104 USA SN 0885-8608 J9 NAT AREA J JI Nat. Areas J. PD APR PY 2008 VL 28 IS 2 BP 171 EP 179 DI 10.3375/0885-8608(2008)28[171:EAOCFP]2.0.CO;2 PG 9 WC Ecology; Forestry SC Environmental Sciences & Ecology; Forestry GA 297KJ UT WOS:000255615300009 ER PT J AU Hill, MJ McWilliams, GD Garcia, D Chen, B Munroe, M Hoeldtke, NJ AF Hill, Micah J. McWilliams, Grant D. Garcia, Denise Chen, Bruce Munroe, Michelle Hoeldtke, Nathan J. TI The effect of membrane sweeping in uncomplicated pregnancies on prelabor rupture of membranes: A prospective randomized controlled trial SO OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 56th Annual Clinical Meeting of the American-College-of-Obstetricians-and-Gynecologists CY MAY 03-07, 2008 CL New Orleans, LA SP Amer Coll Obstetricians & Gynecologists C1 [Hill, Micah J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RI Hill, Micah/A-6777-2009 NR 0 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD APR PY 2008 VL 111 IS 4 SU S BP 11S EP 11S PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 280NT UT WOS:000254434200025 ER PT J AU Nielsen, PE AF Nielsen, Peter E. TI Group prenatal care and perinatal outcomes: A randomized controlled trial SO OBSTETRICS AND GYNECOLOGY LA English DT Letter C1 USA, Med Corps, Dept OB GYN, Madigan Army Med Ctr, Tacoma, WA USA. RP Nielsen, PE (reprint author), USA, Med Corps, Dept OB GYN, Madigan Army Med Ctr, Tacoma, WA USA. NR 4 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD APR PY 2008 VL 111 IS 4 BP 993 EP 993 DI 10.1097/AOG.0b013e31816bf4be PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 280NO UT WOS:000254433700029 PM 18378763 ER PT J AU Kirsch, JC Jones, BK Johnson, JL Gregory, DA AF Kirsch, James C. Jones, Brian K. Johnson, John L. Gregory, Don A. TI Real-time, full-resolution liquid crystal-based stereoscopic display SO OPTICAL ENGINEERING LA English DT Article DE stereoscopic; LCD; 3D; flat panel; polarization encoding AB Wheatstone invented the first stereoscopic display on record in 1834. Numerous approaches to the display of stereo imagery have been demonstrated since; however, all suffer from various drawbacks. Stereoscopic displays typically require the user to wear special headgear. Autostereoscopic displays typically have tight limitations on the position of the viewer's head. We investigate an architecture consisting of two readily available, inexpensive twisted nematic liquid crystal display (TN-LCD) panels sandwiched together to form a compact, rugged stereoscopic display. We describe the theory of operation, the experimental determination of the liquid crystal display modulation characteristics, and modifications to the theory of operation, as a consequence of the experimental results. (C) 2008 Society of Photo-Optical Instrumentation Engineers. C1 [Kirsch, James C.; Jones, Brian K.] USA, Res Dev & Engn Command, AMSRD AMR WS PL, Redstone Arsenal, AL 35898 USA. [Johnson, John L.] USA, Int Technol Ctr Atlantic, London NW1 5TH, England. [Gregory, Don A.] Univ Alabama, Huntsville, AL 35899 USA. RP Kirsch, JC (reprint author), USA, Res Dev & Engn Command, AMSRD AMR WS PL, Redstone Arsenal, AL 35898 USA. EM jim.kirsch@us.army.mil NR 7 TC 5 Z9 5 U1 0 U2 2 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD APR PY 2008 VL 47 IS 4 AR 044001 DI 10.1117/1.2911722 PG 8 WC Optics SC Optics GA 306IT UT WOS:000256242200009 ER PT J AU Ng, HY Wang, MR Li, DQ Wang, X Martinez, J Panepucci, RR Pathak, K AF Ng, Han-Yong Wang, Michael R. Li, Daqun Wang, Xuan Martinez, Jose Panepucci, Roberto R. Pathak, Kachesh TI 4X4 wavelength-reconfigurable photonic switch based on thermally tuned silicon microring resonators SO OPTICAL ENGINEERING LA English DT Article DE microring resonator; photonic switch; thermo-optic tuning; silicon AB Microring resonators (MRs) are important photonic devices for large-port-count photonic circuits owing to their micrometer-scale device sizes. We describe the implementation of a 4 X 4 wavelength-reconfigurable photonic switch consisting of eight tunable MRs fabricated on a less expensive material platform: silicon on insulator. Wavelength reconfiguration is achieved through independent thermo-optic tuning of MRs with localized Nichrome microheaters fabricated on the same silicon-on-insulator substrate. A free spectral range of 18 nm and a 3-dB linewidth of 0.1 nm were observed for the fabricated MRs with a diameter of approximately 10 mu m. The switch device shows negligible channel crosstalk (<0.01 nm) and moderate switching response time (<1 ms). The switch can potentially be scaled up to benefit the development of large-scale integrated photonics. (C) 2008 Society of Photo-Optical Instrumentation Engineers. C1 [Ng, Han-Yong; Wang, Michael R.] Univ Miami, Dept Elect & Comp Engn, Coral Gables, FL 33124 USA. [Li, Daqun] New Span Opto Technol Inc, Miami, FL 33177 USA. [Wang, Xuan; Martinez, Jose; Panepucci, Roberto R.] Florida Int Univ, Dept Elect & Comp Engn, Miami, FL 33174 USA. [Pathak, Kachesh] USA, Space & Missile Def Command, Huntsville, AL 35807 USA. RP Ng, HY (reprint author), Univ Miami, Dept Elect & Comp Engn, Coral Gables, FL 33124 USA. EM mwang@miami.edu NR 8 TC 10 Z9 10 U1 0 U2 3 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD APR PY 2008 VL 47 IS 4 AR 044601 DI 10.1117/1.2909662 PG 8 WC Optics SC Optics GA 306IT UT WOS:000256242200015 ER PT J AU Robitschek, J Wang, D Hall, D AF Robitschek, Jon Wang, David Hall, Danw TI Treatment of linear scleroderma "en coup de sabre" with AlloDerm tissue matrix SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID ABNORMALITIES; GRAFT C1 [Robitschek, Jon; Hall, Danw] Tripler Army Med Ctr, Honolulu, HI 96818 USA. [Wang, David] Med Coll Georgia, Dept Neurol Surg, Augusta, GA 30912 USA. RP Robitschek, J (reprint author), Tripler Army Med Ctr, 480 Mananai Pl Unit S, Honolulu, HI 96818 USA. EM lonesomedoc2@yahoo.com NR 6 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2008 VL 138 IS 4 BP 540 EP 541 DI 10.1016/j.otohns.2007.07.037 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 283MY UT WOS:000254641500028 PM 18359372 ER PT J AU Eberly, MD Soh, EK Bannister, SP Tavaf-Motamen, H Scott, JS AF Eberly, Matthew D. Soh, Eugene K. Bannister, Sean P. Tavaf-Motamen, Houman Scott, John S. TI Isolated cardiac cysticercosis in an adolescent SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE cysticercosis; cardiac; Taenia solium ID MYOCARDIAL CYSTICERCOSIS; DISEASE; SOLIUM AB Cardiac cysticercosis is a rare and typically asymptomatic infection. We report a case of a young mail from Cameroon with a left ventricular cyst discovered during a screening echocardiogram. Computed tomography and plain films did not reveal additional cysts. Serology was negative. The patient had the cyst surgically removed for suspected echinococcosis. Sectioning demonstrated a cysticercus. The literature on cardiac cysticercosis is reviewed. C1 [Eberly, Matthew D.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Pediat, Bethesda, MD 20814 USA. [Soh, Eugene K.] Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. [Bannister, Sean P.; Tavaf-Motamen, Houman] Walter Reed Army Med Ctr, Dept Cardiothorac Surg, Washington, DC 20307 USA. [Scott, John S.] Walter Reed Army Med Ctr, Dept Pediat Cardiol, Washington, DC 20307 USA. RP Eberly, MD (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM meberly@usuhs.mil NR 26 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD APR PY 2008 VL 27 IS 4 BP 369 EP 371 DI 10.1097/INF.0b013e318163d316 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA 283NN UT WOS:000254643100021 PM 18316979 ER PT J AU Adelman, WP AF Adelman, William P. TI Basic training for the pediatrician: How to provide comprehensive anticipatory guidance regarding military service SO PEDIATRICS LA English DT Editorial Material ID OPERATION IRAQI FREEDOM; MENTAL-HEALTH PROBLEMS; CARE; AFGHANISTAN; ADOLESCENTS; STRESS; WAR C1 Walter Reed Army Med Ctr, Dept Pediat, Adolescent Med Serv, Laurel, MD 20708 USA. RP Adelman, WP (reprint author), Walter Reed Army Med Ctr, Dept Pediat, Adolescent Med Serv, 6900 Georgia Ave NW, Laurel, MD 20708 USA. EM william.adelman@us.army.mil NR 39 TC 1 Z9 1 U1 1 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 2008 VL 121 IS 4 BP E993 EP E997 DI 10.1542/peds.2007-2060 PG 5 WC Pediatrics SC Pediatrics GA 282OJ UT WOS:000254576800081 PM 18381527 ER PT J AU Meyers, R Deacon, KS Shih, Y AF Meyers, Ron Deacon, Keith S. Shih, Yanhua TI Ghost-imaging experiment by measuring reflected photons SO PHYSICAL REVIEW A LA English DT Article ID COHERENT; LIGHT; ENTANGLEMENT; DIFFRACTION; STATES; BEAMS; FIELD AB A CCD array is placed facing a chaotic light source and gated by a photon counting detector that simply counts all randomly scattered and reflected photons from an object. A "ghost" image of the object is then observed in the gated CCD. Differing from all published ghost-imaging experiments, this setup captures ghosts from scattered and reflected light of an object, instead of the transmitted ones. This new feature is not only useful for practical applications, but is also important fundamentally. It further explores the nonclassical interference nature of thermal light ghost imaging. C1 [Meyers, Ron; Deacon, Keith S.] USA, Res Lab, Adelphi, MD 20783 USA. [Shih, Yanhua] Univ Maryland, Dept Phys, Baltimore, MD 21250 USA. RP Meyers, R (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 31 TC 123 Z9 127 U1 5 U2 24 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 EI 1094-1622 J9 PHYS REV A JI Phys. Rev. A PD APR PY 2008 VL 77 IS 4 AR 041801 DI 10.1103/PhysRevA.77.041801 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 295EF UT WOS:000255457100018 ER PT J AU Ryan, KL Batchinsky, A McManus, JG Rickards, CA Convertino, VA AF Ryan, Kathy L. Batchinsky, Andriy McManus, John G. Rickards, Caroline A. Convertino, Victor A. TI Changes in pulse character and mental status are late responses to central hypovolemia SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE hemorrhagic shock; lower body negative pressure; cardiovascular collapse ID SYSTOLIC BLOOD-PRESSURE; BODY NEGATIVE-PRESSURE; TRAUMA PATIENTS; LIFESAVING INTERVENTIONS; IMPEDANCE CARDIOGRAPHY; STROKE VOLUME; PALPATION; FINGER; GUIDELINES; ACCURACY AB Objective. Manual assessment of radial arterial pulse character remains an important determinant of physiological status in military and civilian casualties. This study hypothesized that changes in radial pulse character and mental status (presyncopal symptoms) in humans occur only during the later stages of progressive reductions in central blood volume in close association with systolic blood pressure (SBP). Methods. Pulse character (i.e., normal, weak, absent), estimated stroke volume (SV), SBP, and diastolic blood pressure were measured continuously during baseline supine rest and during progressive reductions of central blood volume to cardiovascular collapse with application of lower body negative pressure (LBNP) in 19 healthy human volunteer subjects. Results. LBNP resulted in a progressive reduction in SV. At early stages of LBNP, both radial pulse character and SBP were well-maintained. Although both radial pulse character and SBP decreased with subsequent increases in LBNP, these changes occurred only after an approximate 55% reduction in SV and were associated with the onset of presyncopal symptoms. Changes in mental status did not occur until the point of cardiovascular collapse. Conclusions. In this model of progressive central hypovolemia secondary to application of LBNP in humans, radial pulse character score decreased in concert and was highly correlated with decreases in SBP. In support of our hypothesis, changes in pulse character, SBP, and mental status occurred only after significant reductions in SV, suggesting that these standard vital signs may not be early indicators of central hypovolemia. C1 [Ryan, Kathy L.; Batchinsky, Andriy; McManus, John G.; Rickards, Caroline A.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Ryan, KL (reprint author), USA, Inst Surg Res, Bldg 3611,3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM kathy.ryan@amedd.army.mil NR 28 TC 13 Z9 13 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD APR-JUN PY 2008 VL 12 IS 2 BP 192 EP 198 DI 10.1080/10903120801907562 PG 7 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 294XN UT WOS:000255439700009 PM 18379916 ER PT J AU McManus, JG Ryan, KL Morton, MJ Rickards, CA Cooke, WH Convertino, VA AF McManus, John G. Ryan, Kathy L. Morton, Melinda J. Rickards, Caroline A. Cooke, William H. Convertino, Victor A. TI Limitations of end-tidal CO2 as an early indicator of central hypovolemia in humans SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE hemorrhagic shock; lower body negative pressure; cardiovascular collapse ID BODY NEGATIVE-PRESSURE; TRAUMA TRIAGE RULE; CARBON-DIOXIDE; CARDIAC-OUTPUT; HEMORRHAGIC-SHOCK; BLOOD-PRESSURE; CARDIOPULMONARY-RESUSCITATION; SUBLINGUAL CAPNOMETRY; NONINVASIVE METHOD; CIRCULATORY SHOCK AB Objective. This study tested the hypothesis that pulmonary end-tidal CO2 (PETCO2) tracks reductions in central blood volume in human volunteers exposed to progressive central hypovolemia. Methods. Measurements of PETCO2, Systolic (SBP), diastolic (DBP), and mean arterial (MAP) blood pressures, heart rate (HR), stroke volume (SV), and respiratory rate (RR) were obtained in 50 healthy human subjects during baseline supine rest and exposure to progressive reductions of central blood volume produced by application of lower body negative pressure (LBNP). Results. As increasing amounts of LBNP were applied, SBP, DBP, MAP, HR, SV, and PETCO2 decreased (p < 0.001). RR was not altered (p = 1.0). The decrease in PETCO2 did not begin to occur until 40% of maximal LBNP was applied. While PETCO2 decreased progressively thereafter, the range of baseline values (28.8-49.2 mmHg) varied more than the reduction in PETCO2 elicited by maximal LBNP (baseline = 40.1 +/- 0.6 mmHg; maximal LBNP = 29.8 +/- 11.0 mmHg). The earliest significant alteration was observed in SV, which occurred at 20% of maximal LBNP. MAP did not decline significantly until 80% of maximal LBNP was reached. PETCO2 was correlated positively with SV (r(2) = 0.87). Conclusions. Although PETCO2 tracked decreases in SV in this human model of progressive central hypovolemia, reductions in PETCO2 were small relative to the range of baseline values. Thus, monitoring such small reductions in PETCO2 as an early warning of imminent cardiovascular collapse during hemorrhage may not be clinically useful without monitors capable of providing continuous trending. C1 [McManus, John G.; Ryan, Kathy L.; Morton, Melinda J.; Rickards, Caroline A.; Cooke, William H.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Ryan, KL (reprint author), USA, Inst Surg Res, Bldg 3611,3400 Rawley Chambers Ave, Ft Sam Houston, TX 78234 USA. EM kathyryan@amedd.army.mil NR 48 TC 7 Z9 8 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD APR-JUN PY 2008 VL 12 IS 2 BP 199 EP 205 DI 10.1080/10903120801907182 PG 7 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 294XN UT WOS:000255439700010 PM 18379917 ER PT J AU Shende, R Subramanian, S Hasan, S Apperson, S Thiruvengadathan, R Gangopadhyay, K Gangopadhyay, S Redner, P Kapoor, D Nicolich, S Balas, W AF Shende, Rajesh Subramanian, Senthil Hasan, Sharneent Apperson, Steven Thiruvengadathan, Rajagopalan Gangopadhyay, Keshab Gangopadhyay, Shubhra Redner, Paul Kapoor, Deepak Nicolich, Steven Balas, Wendy TI Nanoenergetic composites of CuO nanorods, nanowires, and Al-nanoparticles SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Al-nanoparticles; combustion wave velocity; CuO nanorods/nanowires; poly(4-vinyl pyridine); self-assembly ID ROUTE; FILM AB This paper reports on the synthesis of the nanoenergetic composites containing CuO nanorods and nanowires, and A1-nanoparticles. Nanorods and nanowires were synthesized using poly(ethylene glycol) templating method and combined with Al-nanoparticles using ultrasonic mixing and self-assembly methods. Poly(4-vinylpyridine) was used for the self-assembly of Al-nanoparticles around the nanorods. At the optimized values of equivalence ratio, sonication time, and Al-particle size, the combustion wave speed of 1650 m s(-1) was obtained for the nanorods-based energetics. For the composite of nanowires and Al-nanoparticles the speed was increased to 1900 m s(-1). The maximum combustion wave speed of 2400 m s-1 was achieved for the self-assembled composite, which is the highest known so far among the nanoenergetic materials. It is possible that in the self assembled composites, the interfacial contact between the oxidizer and fuel is higher and resistance to overall diffusional process is lower, thus enhancing the performance. C1 [Shende, Rajesh; Subramanian, Senthil; Hasan, Sharneent; Apperson, Steven; Thiruvengadathan, Rajagopalan; Gangopadhyay, Keshab; Gangopadhyay, Shubhra] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. [Redner, Paul; Kapoor, Deepak; Nicolich, Steven; Balas, Wendy] USA, ARDEC, Arsenal, NJ 07806 USA. RP Gangopadhyay, S (reprint author), Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. EM gangopadhyays@missouri.edu OI Thiruvengadathan, Rajagopalan/0000-0001-9609-3245 NR 26 TC 68 Z9 73 U1 5 U2 30 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD APR PY 2008 VL 33 IS 2 BP 122 EP 130 DI 10.1002/prep.200800212 PG 9 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 293SU UT WOS:000255355800008 ER PT J AU Ahmed, SA Olson, MA Ludivico, ML Gilsdorf, J Smith, LA AF Ahmed, S. Ashraf Olson, Mark A. Ludivico, Matthew L. Gilsdorf, Janice Smith, Leonard A. TI Identification of residues surrounding the active site of type a botulinum neurotoxin important for substrate recognition and catalytic activity SO PROTEIN JOURNAL LA English DT Article DE botulinum neurotoxin; substrate recognition; zinc-endopeptidase; catalytic domain; site-directed mutagenesis ID LIGHT-CHAIN; SEROTYPE-A; STRUCTURAL-ANALYSIS; CRYSTAL-STRUCTURE; BINDING; PROTEIN; TOXIN; PURIFICATION; ASSOCIATION; EXPRESSION AB Type A botulinum neurotoxin is one of the most lethal of the seven serotypes and is increasingly used as a therapeutic agent in neuromuscular dysfunctions. Its toxic function is related to zinc-endopeptidase activity of the N-terminal light chain (LC) on synaptosome-associated protein-25 kDa (SNAP-25) of the SNARE complex. To understand the determinants of substrate specificity and assist the development of strategies for effective inhibitors, we used site-directed mutagenesis to investigate the effects of 13 polar residues of the LC on substrate binding and catalysis. Selection of the residues for mutation was based on a computational analysis of the three-dimensional structure of the LC modeled with a 17-residue substrate fragment of SNAP-25. Steady-state kinetic parameters for proteolysis of the substrate fragment were determined for a set of 16 single mutants. Of the mutated residues non-conserved among the serotypes, replacement of Arg-230 and Asp-369 by polar or apolar residues resulted in drastic lowering of the catalytic rate constant (k(cat)), but had less effect on substrate affinity (K-m). Substitution of Arg-230 with Lys decreased the catalytic efficiency (k(cat)/K-m) by 50-fold, whereas replacement by Leu yielded an inactive protein. Removal of the electrostatic charge at Asp-369 by mutation to Asn resulted in 140-fold decrease in k(cat)/K-m. Replacement of other variable residues surrounding the catalytic cleft (Glu-54, Glu-63, Asn-66, Asp-130, Asn-161, Glu-163, Glu-170, Glu-256), had only marginal effect on decreasing the catalytic efficiency, but unexpectedly the substitution of Lys-165 with Leu resulted in fourfold increase in k(cat)/K-m. For comparison purposes, two conserved residues Arg-362 and Tyr-365 were investigated with substitutions of Leu and Phe, respectively, and their catalytic efficiency decreased 140- and 10-fold, respectively, whereas substitution of the tyrosine ring with Asn abolished activity. The altered catalytic efficiencies of the mutants were not due to any significant changes in secondary or tertiary structures, or in zinc content and thermal stability. We suggest that, despite the large minimal substrate size for catalysis, only a few non-conserved residues surrounding the active site are important to render the LC competent for catalysis or provide conformational selection of the substrate. C1 [Ahmed, S. Ashraf; Olson, Mark A.; Ludivico, Matthew L.; Gilsdorf, Janice; Smith, Leonard A.] USA, Dept Mol Biol, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Olson, Mark A.] USA, Dept Cell Biol & Biochem, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Ahmed, SA (reprint author), USA, Dept Mol Biol, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM syed.ahmed@amedd.army.mil NR 42 TC 22 Z9 22 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1572-3887 EI 1573-4943 J9 PROTEIN J JI Protein J. PD APR PY 2008 VL 27 IS 3 BP 151 EP 162 DI 10.1007/s10930-007-9118-8 PG 12 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 302HB UT WOS:000255958300002 PM 18213512 ER PT J AU Hospenthal, DR AF Hospenthal, Duane R. TI Pulmonary fungal infections SO SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Editorial Material C1 Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr,MCHE MDI, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 1069-3424 J9 SEMIN RESP CRIT CARE JI Semin. Respir. Crit. Care Med. PD APR PY 2008 VL 29 IS 2 BP 101 EP 102 DI 10.1055/s-2008-1063848 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 280KR UT WOS:000254426200001 PM 18365991 ER PT J AU D'Avignon, LC Schofield, CM Hospenthal, DR AF D'Avignon, Laurie C. Schofield, Christina M. Hospenthal, Duane R. TI Pneumocystis pneumonia SO SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Review DE Pneumocystis; P. jiroveci; P. carinii; PCP; pneumocystosis ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CARINII DIHYDROPTEROATE SYNTHASE; BONE-MARROW-TRANSPLANTATION; VIRUS-INFECTED PATIENTS; F-SP HOMINIS; TRIMETHOPRIM-SULFAMETHOXAZOLE; RANDOMIZED-TRIAL; HIV-INFECTION; LACTATE-DEHYDROGENASE; AIDS PATIENTS AB Pneumocystis is an opportunistic fungus that is a major cause of morbidity and mortality in immunocompromised hosts. Despite a decline in incidence with the advent of highly active antiretroviral therapy (HAART), Pneumocystis remains the most common opportunistic infection in patients with the acquired immunodeficiency syndrome (AIDS) and is an increasing cause of disease in patients with other forms of immunosuppression. Although there have been advances in the prevention and treatment of this infection, the mortality for Pneumocystis pneumonia (PCP) in the setting of AIDS remains 10 to 20%. The mortality for patients with other forms of immunosuppression is poorly defined but may actually be higher than that reported in the setting of AIDS. The continued severity of PCP in the AIDS population, its increasing frequency in other immunosuppressed populations, and increasing evidence that normal hosts may serve as a reservoir for the organism merit continued evaluation of the epidemiology, clinical presentation, diagnosis, and treatment of this infection. C1 [D'Avignon, Laurie C.; Schofield, Christina M.; Hospenthal, Duane R.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP D'Avignon, LC (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr,MCHE MDI, Ft Sam Houston, TX 78234 USA. EM laurie.davignon@amedd.army.mil NR 87 TC 11 Z9 11 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 1069-3424 J9 SEMIN RESP CRIT CARE JI Semin. Respir. Crit. Care Med. PD APR PY 2008 VL 29 IS 2 BP 132 EP 140 DI 10.1055/s-2008-1063852 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 280KR UT WOS:000254426200005 PM 18365995 ER PT J AU Handa, H Gurczynski, S Jackson, MP Auner, G Walker, J Mao, G AF Handa, Hitesh Gurczynski, Stephen Jackson, Matthew P. Auner, Gregory Walker, Jeremy Mao, Guangzhao TI Recognition of Salmonella typhimurium by immobilized phage P22 monolayers SO SURFACE SCIENCE LA English DT Article DE bacteriophage; salmonella typhimurium; lipopolysaccharide membrane ID SELF-ASSEMBLED MONOLAYERS; QUARTZ-CRYSTAL MICROBALANCE; ANTIBODY IMMOBILIZATION; COVALENT IMMOBILIZATION; PIEZOELECTRIC BIOSENSOR; BACTERIOPHAGE THERAPY; SURFACES; DISPLAY; IMMUNOSENSOR; RECEPTOR AB Phages are promising alternatives to antibodies as the biorecognition element in a variety of biosensing applications. In this study, a monolayer of bacteriophage P22 whose tailspike proteins specifically recognize Salmonella serotypes was covalently bound to glass substrates through a bifunctional cross linker 3-aminopropyltrimethoxysilane. The specific binding of Salmonella typhimurium to the phage monolayer was studied by enzyme-linked immunosorbent assay and atomic force microscopy. Escherichia coli and a Gram-positive bacterium Listeria monocytogenes were also studied as control bacteria. The P22 particles show strong binding affinity to S. typhimurium. In addition, the dried P22 monolayer maintained 50% binding capacity to S. typhimurium after a one-week storage time. This is a promising method to prepare phage monolayer coatings on surface plasmon resonance and acoustic biosensor substrates in order to utilize the nascent phage display technology. (c) 2008 Elsevier B.V. All rights reserved. C1 [Handa, Hitesh; Mao, Guangzhao] Wayne State Univ, Dept Chem Engn & Mat Sci, Detroit, MI 48202 USA. [Gurczynski, Stephen; Jackson, Matthew P.] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA. [Auner, Gregory] Wayne State Univ, Dept Elect & Comp Engn, Detroit, MI 48202 USA. [Walker, Jeremy] USA, RDECOM, Warren, MI 48397 USA. RP Mao, G (reprint author), Wayne State Univ, Dept Chem Engn & Mat Sci, Detroit, MI 48202 USA. EM gzmao@eng.wayne.edu FU NIBIB NIH HHS [R01 EB000741, R01 EB000741-01] NR 52 TC 30 Z9 31 U1 1 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-6028 J9 SURF SCI JI Surf. Sci. PD APR 1 PY 2008 VL 602 IS 7 BP 1392 EP 1400 DI 10.1016/j.susc.2008.01.036 PG 9 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA 292YS UT WOS:000255302600013 PM 19461940 ER PT J AU Dietrich, CS AF Dietrich, Charles S., III TI Obstetrics and gynecology for the general surgeon - Preface SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Editorial Material C1 Tripler Army Med Ctr, Dept Obstet & Gynecol, Gynecol Oncol Serv, Honolulu, HI 96859 USA. RP Dietrich, CS (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Gynecol Oncol Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM chuck.dietrich@us.army.mil NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP XIII EP XIV DI 10.1016/j.suc.2008.02.002 PG 2 WC Surgery SC Surgery GA 294QP UT WOS:000255420900002 PM 18381110 ER PT J AU Boyle, KJ Torrealday, S AF Boyle, Kevin J. Torrealday, Saloa TI Benign gynecologic conditions SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID PELVIC-INFLAMMATORY-DISEASE; UTERINE LEIOMYOMATA; ENDOMETRIOSIS; SYMPTOMATOLOGY; HYSTERECTOMY; LAPAROSCOPY; INFECTION; WOMEN; RISK AB Benign gynecologic conditions constitute the majority of the general gynecologist's practice. Along with health maintenance examinations, contraceptive management, family planning issues, and concerns about incontinence, the gynecologic conditions for which patients commonly present include adnexal masses, leiomyomata, endometriosis, and pelvic inflammatory disease. This article addresses each of these last four entities and incorporates a discussion of their etiologies, clinical presentations, keys to diagnosis, and the various treatment options available. C1 [Boyle, Kevin J.; Torrealday, Saloa] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. RP Boyle, KJ (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM kevin.j.boyle@us.army.mil NR 51 TC 5 Z9 6 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP 245 EP + DI 10.1016/j.suc.2007.12.001 PG 21 WC Surgery SC Surgery GA 294QP UT WOS:000255420900004 PM 18381112 ER PT J AU McWilliams, GDE Hill, MJ Dietrich, CS AF McWilliams, Grant D. E. Hill, Micah J. Dietrich, Charles S., III TI Gynecologic emergencies SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID PELVIC-INFLAMMATORY-DISEASE; CROWN-RUMP LENGTH; ECTOPIC PREGNANCY; ADNEXAL TORSION; TUBOOVARIAN ABSCESSES; DIAGNOSIS; OVARIAN; TRENDS; LAPAROSCOPY; MENORRHAGIA AB Gynecologic emergencies are relatively common and include ectopic pregnancies, adnexal torsion, tubo-ovarian abscess, hemorrhagic ovarian cysts, gynecologic hemorrhage, and vulvovaginal trauma. The purpose of this article is to provide a concise review of these emergencies, focusing on the evaluation and treatment options for the patient. In many cases, other causes of an acute abdomen are in the differential diagnosis. Understanding the tenets of diagnosis helps the surgeon narrow the etiology and guide appropriate treatment. C1 [McWilliams, Grant D. E.] Tripler Army Med Ctr, Dept OB GYN, Honolulu, HI 96859 USA. [Hill, Micah J.] Blanchfield Army Community Hosp, Dept OB GYN, Ft Campbell, KY 42223 USA. [Dietrich, Charles S., III] Tripler Army Med Ctr, Dept OB GYN, Gynecol Oncol Serv, Honolulu, HI 96859 USA. RP McWilliams, GDE (reprint author), Tripler Army Med Ctr, Dept OB GYN, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM grant.mcwilliams@us.army.mil RI Hill, Micah/A-6777-2009 NR 44 TC 28 Z9 32 U1 0 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP 265 EP + DI 10.1016/j.suc.2007.12.007 PG 20 WC Surgery SC Surgery GA 294QP UT WOS:000255420900005 PM 18381113 ER PT J AU Chobanian, N Dietrich, CS AF Chobanian, Nishan Dietrich, Charles S., III TI Ovarian cancer SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID CYTOREDUCTIVE SURGERY; RECTOSIGMOID RESECTION; CARCINOMA; STAGE; MANAGEMENT; WOMEN; RISK; EPIDEMIOLOGY; CHEMOTHERAPY; DIAGNOSIS AB Ovarian cancer ranks fifth in cancer deaths among women and causes more deaths than any other gynecologic malignancy It is estimated that 22,430 new cases will be diagnosed and 15,280 deaths will be attributed to ovarian cancer in the United States in 2007. Despite initial responses to surgery and chemotherapy in up to 80% of cases, more than 75% of affected women ultimately die from complications of disease progression. C1 [Chobanian, Nishan] St Johns Mercy Med Ctr, St Louis, MO 63101 USA. [Dietrich, Charles S., III] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. RP Chobanian, N (reprint author), St Johns Mercy Med Ctr, 607 S New Ballas Rd, St Louis, MO 63101 USA. EM chobnh@stlo.mercy.net NR 43 TC 37 Z9 49 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP 285 EP + DI 10.1016/j.suc.2007.12.002 PG 16 WC Surgery SC Surgery GA 294QP UT WOS:000255420900006 PM 18381114 ER PT J AU Whitcomb, BP AF Whitcomb, Bradford P. TI Gynecologic malignancies SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID PHASE-III TRIAL; SQUAMOUS-CELL CARCINOMA; ADVANCED ENDOMETRIAL CARCINOMA; PELVIC RADIATION-THERAPY; ONCOLOGY-GROUP; CERVICAL-CANCER; BREAST-CANCER; STAGE-I; PROGNOSTIC FACTORS; VULVAR CARCINOMA AB The pioneers in the field of gynecologic oncology set out to establish an evidence-based approach to the care of women with gynecologic cancer, combining the modalities of surgery, chemotherapy, and radiation. Quality of life has become the cornerstone of care for these patients, in addition to advancing survival through surgical technology, collaborative research trials, and molecular approaches to early diagnosis and management. This article addresses the epidemiology, screening, preventive strategies, diagnosis, staging, surgical care, adjuvant therapy, prognosis, and recurrence management of three common gynecologic malignancies encountered in the operating arena: endometrial, cervical, and vulvar cancer. C1 Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. RP Whitcomb, BP (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM bradford.whitcomb@us.army.mil NR 82 TC 8 Z9 11 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP 301 EP + DI 10.1016/j.suc.2008.01.004 PG 18 WC Surgery SC Surgery GA 294QP UT WOS:000255420900007 PM 18381115 ER PT J AU Stany, MP Farley, JH AF Stany, Michael P. Farley, John H. TI Complications of gynecologic surgery SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID ABDOMINAL HYSTERECTOMY; NONCARDIAC SURGERY; LAPAROSCOPIC SURGERY; EPIGASTRIC VESSELS; BOWEL OBSTRUCTION; INCISIONAL HERNIA; CESAREAN DELIVERY; RANDOMIZED-TRIAL; FASCIAL CLOSURE; PELVIC-SURGERY AB Complications during gynecologic surgery result from the proximity of the uterus and ovaries to other critical pelvic structures. These structures include the urinary tract, bowel, nerves, and vasculature. Knowledge of pelvic anatomy is important when performing these procedures and is critical in cases of altered anatomy from adhesive disease and during intraoperative hemorrhage. Recognition and repair of an unintended injury gives the best chance for minimizing sequelae from these complications. C1 [Farley, John H.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. [Stany, Michael P.] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. RP Farley, JH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM jfarley@usuhs.mil NR 63 TC 5 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP 343 EP + DI 10.1016/j.suc.2007.12.004 PG 18 WC Surgery SC Surgery GA 294QP UT WOS:000255420900009 PM 18381117 ER PT J AU Gjelsteen, AC Ching, BH Meyermann, MW Prager, DA Murphy, TF Berkey, BD Mitchell, LA AF Gjelsteen, Andrew C. Ching, Brian H. Meyermann, Mark W. Prager, Douglas A. Murphy, Thomas F. Berkey, Bryan D. Mitchell, Lex A. TI CT, MRI, PET, PET/CT, and ultrasound in the evaluation of obstetric and Gynecologic patients SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID POSITRON-EMISSION-TOMOGRAPHY; UTERINE CERVICAL-CARCINOMA; LYMPH-NODE METASTASIS; ENDOMETRIAL CANCER; OVARIAN-CANCER; FDG-PET; ACUTE APPENDICITIS; F-18-FDG PET; FOLLOW-UP; PREOPERATIVE ASSESSMENT AB The role of imaging in obstetrics and gynecology has undergone a revolution over the past few decades. Well-established methods such as endovaginal ultrasound have had a central role in the evaluation of nongravid patients with pelvic pain, as well as in the workup for ectopic pregnancy and evaluation of adnexal masses. Additional tools include MRI in the evaluation of appendicitis and other potentially surgical conditions in pregnant patients and MRI and CT in the evaluation of surgical complications. Newer tools in the radiology armamentarium include PET scanning which, alongside MRI and CT, are often helpful in staging gynecologic malignancy. The role of imaging in the obstetric and gynecology patient will continue to change as new modalities and techniques are introduced. C1 [Gjelsteen, Andrew C.; Ching, Brian H.; Meyermann, Mark W.; Prager, Douglas A.; Murphy, Thomas F.; Berkey, Bryan D.; Mitchell, Lex A.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Gjelsteen, AC (reprint author), Tripler Army Med Ctr, Dept Radiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM andrew.gjelsteen@us.army.mil NR 83 TC 12 Z9 12 U1 1 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP 361 EP + DI 10.1016/j.suc.2008.01.005 PG 31 WC Surgery SC Surgery GA 294QP UT WOS:000255420900010 PM 18381118 ER PT J AU Hill, CC Pickinpaugh, J AF Hill, Christina C. Pickinpaugh, Jennifer TI Physiologic changes in pregnancy SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID NONOBSTETRIC SURGERY; VOLUME HOMEOSTASIS; TERM PREGNANCY; NORMAL WOMEN; PATIENT; ANESTHESIA; PUERPERIUM; HYPERTENSION; ADAPTATIONS; KIDNEY AB Pregnancy is associated with physiologic changes that affect virtually every organ system in the mother. These physiologic changes allow the parturient to support the growing uterus and fetus and to withstand labor and the postpartum course. Because the gravida may require surgery while pregnant, it is important to have an appreciation of these physiologic changes. These maternal adaptive responses have significant implications for anesthetic, operative, and perioperative management. C1 [Hill, Christina C.; Pickinpaugh, Jennifer] Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Honolulu, HI 96859 USA. RP Hill, CC (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM christina.hill@amedd.army.mil NR 57 TC 26 Z9 30 U1 0 U2 9 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP 391 EP + DI 10.1016/j.suc.2007.12.005 PG 12 WC Surgery SC Surgery GA 294QP UT WOS:000255420900011 PM 18381119 ER PT J AU Dietrich, CS Hill, CC Hueman, M AF Dietrich, Charles S., III Hill, Christina C. Hueman, Matthew TI Surgical diseases presenting in pregnancy SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID INFLAMMATORY-BOWEL-DISEASE; FULMINANT ULCERATIVE-COLITIS; BILIARY-TRACT DISEASE; ACUTE APPENDICITIS; ACUTE ABDOMEN; RISK-FACTORS; GASTROINTESTINAL SURGERY; INTESTINAL-OBSTRUCTION; COMPLICATING PREGNANCY; PATIENT AB Surgical diseases frequently arise in gravid patients, with an estimated 1 in 500 pregnancies requiring nonobstetric surgical intervention. Evaluation and treatment generally are the same as for the nonpregnant patient, but pregnancy may mask some of the typical presenting symptoms, leading to delayed diagnosis. This article highlights some of the more common surgical diseases that may present during pregnancy, including appendicitis, bihary diseases, bowel obstruction, hemorrhoids, inflammatory bowel disease, and malignancies. C1 [Dietrich, Charles S., III] Tripler Army Med Ctr, Dept Obstet & Gynecol, Gynecol Oncol Serv, Honolulu, HI 96859 USA. [Hill, Christina C.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Honolulu, HI 96859 USA. [Hueman, Matthew] Johns Hopkins Univ Hosp, Dept Surg, Baltimore, MD 21287 USA. RP Dietrich, CS (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Gynecol Oncol Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM chuck.dietrich@us.army.mil NR 63 TC 13 Z9 15 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP 403 EP + DI 10.1016/j.suc.2007.12.003 PG 19 WC Surgery SC Surgery GA 294QP UT WOS:000255420900012 PM 18381120 ER PT J AU Hill, CC Pickinpaugh, J AF Hill, Christina C. Pickinpaugh, Jennifer TI Trauma and surgical emergencies in the obstetric patient SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID BLUNT ABDOMINAL-TRAUMA; PERIMORTEM CESAREAN DELIVERY; FETAL OUTCOMES; FETOMATERNAL HEMORRHAGE; ULTRASOUND EXAMINATION; ASSUMPTIONS CORRECT; PREGNANT PATIENTS; MATERNAL TRAUMA; PREDICTORS; VIOLENCE AB Pregnancy always must be considered when evaluating a female trauma victim of reproductive age. When managing the pregnant trauma victim, one must optimize the well-being of two patients, but the health of the mother is of paramount importance. Rapid assessment, treatment, and transport are critical to optimizing maternal and fetal outcome. Evaluation must be performed with an understanding of the physiologic changes that occur in pregnancy. These changes alter maternal response to trauma and require adaptations to care. C1 [Hill, Christina C.; Pickinpaugh, Jennifer] Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Honolulu, HI 96859 USA. RP Hill, CC (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM christina.hill@amedd.army.mil NR 61 TC 19 Z9 19 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD APR PY 2008 VL 88 IS 2 BP 421 EP + DI 10.1016/j.suc.2007.12.006 PG 21 WC Surgery SC Surgery GA 294QP UT WOS:000255420900013 PM 18381121 ER PT J AU Sibert, K Ricci, MA Caputo, M Callas, PW Rogers, FB Charash, W Malone, P Leffler, SM Clark, H Salinas, J Wall, J Kocmoud, C AF Sibert, Kerry Ricci, Michael A. Caputo, Michael Callas, Peter W. Rogers, Frederick B. Charash, William Malone, Pat Leffler, Stephen M. Clark, Harry Salinas, Jose Wall, James Kocmoud, Christopher TI The feasibility of using ultrasound and video laryngoscopy in a mobile telemedicine consult SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Article DE ultrasound; video laryngoscopy; mobile telemedicine; emergency medical services ID TRAUMA CARE AB Emergency healthcare systems in rural communities often have limited access to experienced trauma and emergency physicians. Advanced telecommunication technologies may offer an opportunity to help meet this need. We evaluated healthcare providers' satisfaction with the audio and visual components of an existing telemedicine system, and asked them whether emergency medical services ( EMS) personnel could be supported via telemedicine guidance, using video laryngoscopy and ultrasonography, during vulnerable transport periods. Physicians and technologists at a central workstation were linked to a telemedicine- equipped ambulance providing real- time audio and visual communications during patient transport. A scoring system was created for system evaluation using a scale of 1 - 9. Seven evaluators observed ultrasonography of the carotid vessels and abdominal aorta. Nine evaluators observed an intubation with video laryngoscopy. These observers rated the quality of the images transmitted from the ambulance. Evaluators were asked if this telemedicine system would be suitable for telementoring advanced technical procedures. Mean rating for technical satisfaction with ultrasound was 5.1, the majority of evaluators estimated that they could telementor an abdominal ultrasound examination. The mean rating for technical satisfaction with laryngoscopy was 7.2 with 100% of evaluators estimating they could use the system to telementor intubation. The rating for laryngoscopy was significantly higher than for ultrasound ( p = 0.01). Results of this study suggest that telemedicine may provide an advanced support mechanism for rural EMS personnel and patients. Procedures for advanced airway management and ultrasound diagnosis may someday be managed using a remote telepresence. C1 [Sibert, Kerry; Ricci, Michael A.; Callas, Peter W.; Rogers, Frederick B.; Charash, William; Malone, Pat; Leffler, Stephen M.; Clark, Harry] Fletcher Allen Hlth Care, Burlington, VT 05401 USA. [Sibert, Kerry; Ricci, Michael A.; Callas, Peter W.; Rogers, Frederick B.; Charash, William; Malone, Pat; Leffler, Stephen M.; Clark, Harry] Univ Vermont, Coll Med, Burlington, VT USA. [Caputo, Michael] Washington Univ, Sch Med, St Louis, MO USA. [Salinas, Jose] Brooke Army Med Ctr, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Wall, James; Kocmoud, Christopher] Texas A&M Univ, Texas Ctr Appl Technol, College Stn, TX USA. RP Ricci, MA (reprint author), Fletcher Allen Hlth Care, 111 Colchester Ave Patrick 226, Burlington, VT 05401 USA. EM michael.ricci@vtmednet.org NR 14 TC 9 Z9 9 U1 2 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD APR PY 2008 VL 14 IS 3 BP 266 EP 272 DI 10.1089/tmj.2007.0050 PG 7 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 300KY UT WOS:000255823900039 PM 18570551 ER PT J AU Cardo, LJ Wilder, D Salata, J AF Cardo, Lisa J. Wilder, Donna Salata, Jeanne TI Neutrophil priming, caused by cell membranes and microvesicles in packed red blood cell units, is abrogated by leukocyte depletion at collection SO TRANSFUSION AND APHERESIS SCIENCE LA English DT Article DE neutrophils; packed red cells; leukocyte depletion; microvesicles; storage lesion; cell membrane ID PLATELET-ACTIVATING-FACTOR; SECRETORY PHOSPHOLIPASE A(2); NADPH OXIDASE; SUSCEPTIBILITY; SUPERNATANT; MECHANISMS; APOPTOSIS; RECEPTOR; STORAGE; PRIMES AB Background and objects: Lipids with platelet activating factor (PAF)-like activity in supernatant of packed red blood cells (PRBC) cause priming of the neutrophil respiratory burst. This effect increases with length of storage. Washing of PRBC has been considered as a means to eliminate this effect; however, the role of the cellular component was not evaluated independently of the supernatant. The source of the inflammatory lipids of the supernatant is likely to be cell membranes altered during ageing in storage and therefore, washing will not eliminate neutrophil priming caused by transfusion of aged PRBC units. The ability of washed PRBC to prime mononuclear cells for another known effect of PAF, the production of IL-8, and the probability that this lipid activity is present on microparticles in PRBC supernatant were also investigated. Materials and methods: At collection 10 units of whole blood were split into two equal aliquots one filtered and one unfiltered. PRBC were prepared and stored at 4 degrees C in CPD-AS5. Each week, fresh neutrophils were incubated with samples of washed PRBC and fixed. Change in CD11b, a marker known to increase on the surface of primed neutrophils, was determined by flow cytometry. To determine whether neutrophil priming ability of PRBC supernatant is contained on microvesicles, centrifuged and uncentrifuged supernatant samples were incubated with fresh neutrophils and change in CD11b expression was determined. Plasma IL-8 levels were also measured after exposure of monocytes from fresh whole blood to filtered and unfiltered washed PRBC with and without the addition of fMLP. Results: Washed PRBC caused a 50-116% increase in CD11b neutrophil surface expression over baseline expression. Filtration of whole blood at collection reduced this CD11b up-regulation by 25-34%. Reduction of priming ability by filtration began on the day of collection and persisted for the storage life of the units. Centrifugation resulted in a reduction of CD11b up-regulation of 11-28% compared with unspun supernatant. Incubation of unfiltered PRBC resulted in priming of mononuclear leukocytes for IL-8 production with a 73-109% increase over baseline, but no increase over baseline was seen for incubation with filtered blood. Conclusion: Washing does not eliminate the ability of PRBC units to prime neutrophils and mononuclear cells, because the cellular component of PRBC, in addition to the supernatant, induces priming. Leukodepletion filters significantly reduce these effects compared with unfiltered PRBC. The in vitro beneficial effect of filtration lasts for the shelf life of 42 day units. The ability of PRBC supernatant to prime neutrophils is present on microvesicles. Published by Elsevier Ltd. C1 [Cardo, Lisa J.; Wilder, Donna; Salata, Jeanne] Walter Reed Army Inst Res, Dept Blood Res, Transfus Med Branch, Silver Spring, MD 20910 USA. RP Cardo, LJ (reprint author), Walter Reed Army Inst Res, Dept Blood Res, Transfus Med Branch, 503 Robert Grant Ave,MCR 1N80, Silver Spring, MD 20910 USA. EM Lisa.Cardo@us.army.mil NR 20 TC 29 Z9 30 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1473-0502 J9 TRANSFUS APHER SCI JI Transfus. Apher. Sci. PD APR PY 2008 VL 38 IS 2 BP 117 EP 125 DI 10.1016/j.transci.2008.01.004 PG 9 WC Hematology SC Hematology GA 307RU UT WOS:000256336800005 PM 18343726 ER PT J AU Cardo, LJ Hmel, P Wilder, D AF Cardo, Lisa J. Hmel, Peter Wilder, Donna TI Stored packed red blood cells contain a procoagulant phospholipid reducible by leukodepletion filters and washing SO TRANSFUSION AND APHERESIS SCIENCE LA English DT Article ID MULTIPLE ORGAN FAILURE; ENDOTHELIAL-CELLS; PHOSPHATIDYLSERINE EXPOSURE; IN-VITRO; ERYTHROCYTES; STORAGE; ADHERENCE; ASYMMETRY; LEUKOREDUCTION; NEUTROPHILS AB Background: Ageing RBC gradually increase the exposure of phosphatidylserine (PS) on their surface, due to loss of membrane asymmetry. PS expression on red cells is not normally a significant factor in the hemostatic process, because aged RBC are rapidly cleared from the circulation. We propose that the presence of many altered red cells during massive transfusion can lead to increased procoagulant activity similar to what is seen in disease states where it is known to play a pathophysiologic role in microvascular disease. Study design and methods: Procoagulant activity of phospholipid generated during storage of PRBC was evaluated using PRBC's as the only source of phospholipid in the determination of modified Russell's viper venom times of 10 PRBC units in which half of each unit was left unfiltered and half of each unit filtered. Florescent labeled annexin V binding by PRBC was also assessed by flow cytometry over time in storage. The effect of washing and filtration on these parameters was also determined. Results: As time of storage increased, the Russell's viper venom time of both the unfiltered and filtered units shortened (p < 0.01). There was a significant lengthening of the Russell's viper venom time at all time points measured when unfiltered units were compared to filtered units (p < 0.01). In both unfiltered and filtered units, with increased length of storage, there was a gradual increase in the percentage of cells or particles binding annexin V (p < 0.01). Filtration resulted in a significant reduction in the percentage of cells or particles binding annexin V at all time points measured (p < 0.01). The effect of washing of PRBC units on the RVVT was assessed for unfiltered and filtered units on day 42. Washing resulted in a significant reduction of the RVVT in both unfiltered and filtered groups (P < 0.01). Conclusions: Levels of annexin V binding and procoagulant phospholipid activity similar to levels seen in disease states associated with significant vasoocclusive pathophysiology were found toward the end of the storage period of PRBC units. It was possible to reduce both of these parameters by leukodepletion at collection, and with washing of PRBC at the end of storage. Filtration at collection resulted in a 67% increase in RVVT over unfiltered units by day 42 of storage. On day 42 of storage, washing of filtered units resulted in a 21% increase in RVVT, and washing of unfiltered units resulted in a 34% increase in RVVT. The effects seen with filtration and washing were additive suggesting that in spite of filtration at collection, deterioration of cells continues based on age since further removal of phospholipid can be induced with washing of filtered units on day 42. Published by Elsevier Ltd. C1 [Cardo, Lisa J.; Hmel, Peter; Wilder, Donna] Walter Reed Army Inst Res, Transfus Med Branch, Dept Blood Res, Silver Spring, MD 20910 USA. RP Cardo, LJ (reprint author), Walter Reed Army Inst Res, Transfus Med Branch, Dept Blood Res, 503 Robert Grant Ave,1N80, Silver Spring, MD 20910 USA. EM lisa.cardo@us.army.mil NR 42 TC 33 Z9 33 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1473-0502 J9 TRANSFUS APHER SCI JI Transfus. Apher. Sci. PD APR PY 2008 VL 38 IS 2 BP 141 EP 147 DI 10.1016/j.transci.2007.09.006 PG 7 WC Hematology SC Hematology GA 307RU UT WOS:000256336800008 PM 18346937 ER PT J AU Erickson, EJ AF Erickson, Edward J. TI The Armenians and Ottoman military policy, 1915 SO WAR IN HISTORY LA English DT Article AB Mainstream western scholarship maintains that the Armenian insurrection of 1915 was never an actual threat to the security of the Ottoman state in the First World War and that the relocation of the Armenians of eastern Anatolia was unnecessary. In truth, no study of the Armenian insurrection and its effect oil Ottoman military policy has ever been conducted. This article examines the Ottoman army's lines of communications architecture and logistics posture in eastern Anatolia in 1915. Armenian threats to the logistics and security of the Ottoman armies in Caucasia and Palestine are overlaid on this system. Evolving and escalatory Ottoman military policies are then explained in terms of threat assessments and contemporary counter-insurgency strategy. The article seeks to inform the reader why the Ottomans reacted so vigorously and violently to the events of the spring of 1915. C1 [Erickson, Edward J.] USA, Washington, DC 20310 USA. NR 45 TC 7 Z9 7 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-3445 J9 WAR HIST JI War Hist. PD APR PY 2008 VL 15 IS 2 BP 141 EP 167 DI 10.1177/0968344507087001 PG 27 WC History; International Relations SC History; International Relations GA 303YK UT WOS:000256077000002 ER PT J AU Gowtham, S Scheicher, RH Pandey, R Karna, SP Ahuja, R AF Gowtham, S. Scheicher, Ralph H. Pandey, Ravindra Karna, Shashi P. Ahuja, Rajeev TI First-principles study of physisorption of nucleic acid bases on small-diameter carbon nanotubes SO NANOTECHNOLOGY LA English DT Article ID DNA; FLUORESCENCE; MOLECULES; FORCE AB We report the results of our first-principles study based on density functional theory on the interaction of the nucleic acid base molecules adenine ( A), cytosine ( C), guanine ( G), thymine ( T), and uracil ( U), with a single-walled carbon nanotube (CNT). Specifically, the focus is on the physisorption of base molecules on the outer wall of a ( 5, 0) metallic CNT possessing one of the smallest diameters possible. Compared to the case for CNTs with large diameters, the physisorption energy is found to be reduced in the high-curvature case. The base molecules exhibit significantly different interaction strengths and the calculated binding energies follow the hierarchy G > A > T > C > U, which appears to be independent of the tube curvature. The stabilizing factor in the interaction between the base molecule and CNT is dominated by the molecular polarizability that allows a weakly attractive dispersion force to be induced between them. The present study provides an improved understanding of the role of the base sequence in deoxyribonucleic acid ( DNA) or ribonucleic acid ( RNA) in their interactions with carbon nanotubes of varying diameters. C1 [Gowtham, S.; Scheicher, Ralph H.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Gowtham, S.; Scheicher, Ralph H.; Pandey, Ravindra] Michigan Technol Univ, Multi Scale Technol Inst, Houghton, MI 49931 USA. [Scheicher, Ralph H.; Ahuja, Rajeev] Uppsala Univ, Dept Phys, Condensed Matter Theory Grp, S-75121 Uppsala, Sweden. [Karna, Shashi P.] USA, Res Lab, Weapons & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA. [Ahuja, Rajeev] Royal Inst Technol, Dept Mat & Engn, S-10044 Stockholm, Sweden. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM rhs@mtu.edu; pandey@mtu.edu RI Pandey, Ravi/A-8759-2009; Scheicher, Ralph/G-1740-2012 NR 36 TC 108 Z9 110 U1 1 U2 20 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 EI 1361-6528 J9 NANOTECHNOLOGY JI Nanotechnology PD MAR 26 PY 2008 VL 19 IS 12 AR 125701 DI 10.1088/0957-4484/19/12/125701 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 276WK UT WOS:000254174200023 PM 21817742 ER PT J AU Apperson, S Shende, RV Subramanian, S Tappmeyer, D Gangopadhyay, S Chen, Z Gangopadhyay, K Redner, P Nicholich, S Kapoor, D AF Apperson, S. Shende, R. V. Subramanian, S. Tappmeyer, D. Gangopadhyay, S. Chen, Z. Gangopadhyay, K. Redner, P. Nicholich, S. Kapoor, D. TI Generation of fast propagating combustion and shock waves with copper oxide/aluminum nanothermite composites (vol 91, 243109, 2007) SO APPLIED PHYSICS LETTERS LA English DT Correction C1 [Apperson, S.; Shende, R. V.; Subramanian, S.; Tappmeyer, D.; Gangopadhyay, S.] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. [Chen, Z.] Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. [Gangopadhyay, K.] Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. [Redner, P.; Nicholich, S.; Kapoor, D.] USA, ARDEC, Picatinny Arsenal, NJ 07896 USA. RP Shende, RV (reprint author), Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. EM gangopadhyays@missouri.edu NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 24 PY 2008 VL 92 IS 12 AR 129901 DI 10.1063/1.2901042 PG 1 WC Physics, Applied SC Physics GA 281PJ UT WOS:000254510300110 ER PT J AU Light, B Grenfell, TC Perovich, DK AF Light, Bonnie Grenfell, Thomas C. Perovich, Donald K. TI Transmission and absorption of solar radiation by Arctic sea ice during the melt season SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID OPTICAL-PROPERTIES; LIGHT-REFLECTION; MODEL; ALBEDO; OCEAN; VARIABILITY; EVOLUTION; EXTENTS; SURFACE; TRENDS AB The partitioning of incident solar radiation between sea ice, ocean, and atmosphere strongly affects the Arctic energy balance during summer. In addition to spectral albedo of the ice surface, transmission of solar radiation through the ice is critical for assessing heat and mass balances of sea ice. Observations of spectral irradiance profiles within and transmittance through ice in the Beaufort Sea during the summer of 1998 during the Surface Heat Budget of the Arctic Ocean (SHEBA) are presented. Sites representative of melting multiyear and first-year ice, along with ponded ice were measured. Observed spectral irradiance extinction coefficients (K lambda) show broad minima near 500 nm and strong increases at near-infrared wavelengths. The median K lambda at 600 nm for the bare ice cases is close to 0.8 m(-1) and about 0.6 m(-1) for ponded ice. Values are considerably smaller than the previously accepted value of 1.5 m(-1). Radiative transfer models were used to analyze the observations and obtain inherent optical properties of the ice. Derived scattering coefficients range from 500 m(-1) to 1100 m(-1) in the surface layer and 8 to 30 m(-1) in the ice interior. While ponded ice is known to transmit a significant amount of shortwave radiation to the ocean, the irradiance transmitted through bare, melting ice is also shown to be significant. The findings of this study predict 3 - 10 times more solar radiation penetrating the ice cover than predicted by a current GCM (CCSM3) parameterization, depending on ice thickness, pond coverage, stage of the melt season, and specific vertical scattering coefficient profile. C1 [Light, Bonnie] Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA. [Grenfell, Thomas C.] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA. [Perovich, Donald K.] Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA. RP Light, B (reprint author), Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA. EM bonnie@apl.washington.edu NR 53 TC 73 Z9 76 U1 3 U2 33 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAR 21 PY 2008 VL 113 IS C3 AR C03023 DI 10.1029/2006JC003977 PG 19 WC Oceanography SC Oceanography GA 281UV UT WOS:000254525300001 ER PT J AU Murrill, SR Jacobs, EL Moyer, SK Halford, CE Griffin, ST De Lucia, FC Petkie, DT Franck, CC AF Murrill, Steven R. Jacobs, Eddie L. Moyer, Steven K. Halford, Carl E. Griffin, Steven T. De Lucia, Frank C. Petkie, Douglas T. Franck, Charmaine C. TI Terahertz imaging system performance model for concealed-weapon identification SO APPLIED OPTICS LA English DT Article ID SECURITY APPLICATIONS; TECHNOLOGY AB The U.S. Army Night Vision and Electronic Sensors Directorate (NVESD) and the U.S. Army Research Laboratory have developed a terahertz (THz) -band imaging system performance model for detection and identification of concealed weaponry. The MATLAB-based model accounts for the effects of all critical sensor and display components and for the effects of atmospheric attenuation, concealment material attenuation, and active illumination. The model is based on recent U.S. Army NVESD sensor performance modeling technology that couples system design parameters to observer-sensor field performance by using the acquire methodology for weapon identification performance predictions. This THz model has been developed in support of the Defense Advanced Research Project Agencies' Terahertz Imaging Focal-Plane Technology (TIFT) program and is currently being used to guide the design and development of a 0.650 THz active-passive imaging system. This paper will describe the THz model in detail, provide and discuss initial modeling results for a prototype THz imaging system, and outline plans to calibrate and validate the model through human perception testing. (c) 2008 Optical Society of America. C1 [Murrill, Steven R.] Army Res Lab, Adelphi, MD 20783 USA. [Jacobs, Eddie L.; Halford, Carl E.; Griffin, Steven T.] Univ Memphis, Dept Elect & Comp Engn, Memphis, TN 38152 USA. [Moyer, Steven K.] USA, Night Vis & Elect Sensors Direcrorate, Ft Belvoir, VA 22060 USA. [De Lucia, Frank C.] Ohio State Univ, Dept Phys, Columbus, OH 43210 USA. [Petkie, Douglas T.] Wright State Univ, Dept Phys, Dayton, OH 45435 USA. [Franck, Charmaine C.] CACI Technol Inc, Ft Belvoir, VA 22060 USA. RP Murrill, SR (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM steve.murrill@us.army.mil NR 18 TC 17 Z9 18 U1 1 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAR 20 PY 2008 VL 47 IS 9 BP 1286 EP 1297 DI 10.1364/AO.47.001286 PG 12 WC Optics SC Optics GA 289IK UT WOS:000255048000017 PM 18709076 ER PT J AU Straight, TM Ottolini, MG Prince, GA Eichelberger, MC AF Straight, Timothy M. Ottolini, Martin G. Prince, Gregory A. Eichelberger, Maryna C. TI Antibody contributes to heterosubtypic protection against influenza A-induced tachypnea in cotton rats SO VIROLOGY JOURNAL LA English DT Article ID VIRUS-INFECTION; CROSS-PROTECTION; VACCINE; MICE; IMMUNITY; NEURAMINIDASE; LYMPHOCYTES; REQUIRES; ANTIGEN; CELLS AB Background: Influenza virus infection or vaccination evokes an antibody response to viral hemagglutinin ( HA) and neuraminidase (NA) surface glycoproteins, which results in immunity against influenza A viruses of the same HA and NA subtype. A heterosubtypic immune response that offers some protection against different influenza A subtypes has been suggested from epidemiologic studies in human influenza outbreaks, and has been induced in experimental animal models. Original studies of such cross-protection showed that cytotoxic T lymphocytes (CTL) protect H3N2-immune mice from a lethal H1N1 infection. More recent studies in mice demonstrate that antibodies also contribute to heterosubtypic immunity (HSI). We previously demonstrated that HSI in cotton rats ( Sigmodon hispidus) is characterized by protection of H3N2-immune animals from influenza H1N1-induced increase in respiratory rate (tachypnea). Alternatively, H1N1-immune animals are protected from H3N2-induced tachypnea. The experiments described in this report were designed to elucidate the immune mechanism that prevents this very early sign of disease. Results: Our results show that cotton rats provided with H1N1-immune serum prior to challenge with an H3N2virus were protected from influenza-associated tachypnea, with the degree of protection correlating with the antibody titer transferred. Immunization with an inactivated preparation of virus delivered intramuscularly also provided some protection suggesting that CTL and/or mucosal antibody responses are not required for protection. Antibodies specific for conserved epitopes present on the virus exterior are likely to facilitate this protection since prophylactic treatment of cotton rats with anti-M2e ( the extracellular domain of M2) but not anti-nucleoprotein (NP) reduced virus-induced tachypnea. Conclusion: In the cotton rat model of heterosubtypic immunity, humoral immunity plays a role in protecting animals from influenza-induced tachypea. Partial protection against respiratory disease caused by different influenza A subtypes can be attained with either live virus administered intranasally or inactivated virus delivered intramuscularly suggesting that either vaccine regimen may provide some protection against potential pandemic outbreaks in humans. C1 [Eichelberger, Maryna C.] US FDA, CBER, Bethesda, MD 20014 USA. [Straight, Timothy M.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Straight, Timothy M.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Ottolini, Martin G.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Prince, Gregory A.] Virion Syst Inc, Rockville, MD USA. RP Eichelberger, MC (reprint author), US FDA, CBER, Bethesda, MD 20014 USA. EM Timothy.Straight@amedd.army.mil; mottolini@usuhs.mil; gprince@erols.com; Maryna.Eichelberger@fda.hhs.gov NR 22 TC 17 Z9 19 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD MAR 20 PY 2008 VL 5 AR 44 DI 10.1186/1743-422X-5-44 PG 9 WC Virology SC Virology GA 286RP UT WOS:000254864000001 PM 18355405 ER PT J AU Laiyemo, AO Murphy, G Albert, PS Wang, Z Cross, AJ Marcus, PM Caan, B Marshall, JR Lance, P Paskett, ED Weissfeld, J Slattery, ML Burt, R Iber, F Shike, M Kikendall, JW Lanza, E Schatzkin, A AF Laiyemo, Adeyinka O. Murphy, Gwen Albert, Paul S. Wang, Zhuoqiao Cross, Amanda J. Marcus, Pamela M. Caan, Bette Marshall, James R. Lance, Peter Paskett, Electra D. Weissfeld, Joel Slattery, Martha L. Burt, Randall Iber, Frank Shike, Moshe Kikendall, J. Walter Lanza, Elaine Schatzkin, Arthur TI Postpolypectomy colonoscopy surveillance guidelines: Predictive accuracy for advanced adenorna at 4 years SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID CLINICAL-PRACTICE GUIDELINES; AMERICAN-CANCER-SOCIETY; PRIMARY-CARE PHYSICIANS; COLORECTAL-CANCER; NATIONAL-SURVEY; SCREENING COLONOSCOPY; ADENOMATOUS POLYPS; FOLLOW-UP; RECURRENCE; POLYPECTOMY AB Background: Lack of confidence in postpolypectomy surveillance guidelines may be a factor in the observed low adherence rates among providers. Objective: To assess the 2006 postpolypectomy colonoscopy surveillance guidelines, which recommend 3-year follow-up colonoscopy for individuals with high-risk adenomas (defined as >= 3 adenomas or any advanced adenomas) and 5- to 10-year follow-up for patients with 2 or fewer nonadvanced adenomas, who are considered to be at low risk. Design: Analysis of prospective data from the Polyp Prevention Trial. Setting: United States. Participants: 1905 patients who had colorectal adenomas removed at baseline screening or diagnostic colonoscopy and completed the trial. Measurements: Baseline adenoma characteristics, risk-stratified according to definitions used in the guidelines, were examined as predictors for advanced adenoma recurrence. Results: 125 patients (6.6%) had advanced and 629 (33.0%) had nonadvanced adenoma recurrence; 1151 (60.4%) had no recurrence within 4 years of follow-up. The probability of advanced adenoma recurrence was 0.09 (95% Cl, 0.07 to 0.11) among patients with high-risk adenomas at baseline and 0.05 (Cl, 0.04 to 0.06) among those with low-risk adenomas at baseline. The relative risk for advanced adenoma recurrence for patients with high-risk adenomas versus those with low-risk adenomas at baseline was 1.68 (Cl, 1.19 to 2.38) when advanced adenoma recurrence was compared with no advanced adenoma recurrence and 1.76 (Cl, 1.26 to 2.46) when advanced adenoma recurrence was compared with no adenoma recurrence. The c-statistics for these 2 comparisons were 0.68 and 0.72, respectively. Limitation: Participants were self-selected and had restrictions on the degree of obesity. Conclusion: Although the risk for recurrence of advanced adenoma within 4 years is greater for patients with high-risk adenomas at baseline than for those with low-risk adenomas, the discrimination of this risk stratification scheme is relatively low. C1 NIH, Natl Canc Inst, Bethesda, MD 20892 USA. Informat Management Serv Inc, Rockville, MD USA. Kaiser Fdn Res Inst, Oakland, CA USA. Roswell Pk Canc Inst, Buffalo, NY USA. Arizona Canc Ctr, Tucson, AZ USA. Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA. Univ Pittsburgh, Pittsburgh, PA USA. Univ Utah, Salt Lake City, UT USA. Edward Hines Jr Hosp Vet Affairs Med Ctr, Hines, IL USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Laiyemo, AO (reprint author), NCI, Div Canc Prevent, Biometry Res Grp, Canc Prevent Fellowship Program, 6130 Execut Blvd,Suite 3121, Bethesda, MD 20892 USA. EM laiyemoa@mail.nih.gov RI Murphy, Gwen/G-7443-2015 FU Intramural NIH HHS NR 35 TC 60 Z9 61 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAR 18 PY 2008 VL 148 IS 6 BP 419 EP 426 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 279KT UT WOS:000254354800002 PM 18347350 ER PT J AU Ellsworth, DL Weyandt, J Patney, HL Love, B Burke, A Haberkorn, MJ Neatrour, DM Vernalis, MN AF Ellsworth, Darrell L. Weyandt, Jamie Patney, Heather L. Love, Brad Burke, Amy Haberkorn, Mary Jane Neatrour, David M. Vernalis, Marina N. TI Changes in global gene expression profiles during a lifestyle change program for heart disease reversal correlate with CAD risk factor improvement SO CIRCULATION LA English DT Meeting Abstract CT 48th Annal Scientific Conference on Cardiovascular Disease Epidemiology and Prevention CY MAR 13-15, 2008 CL Colorado Springs, CO C1 [Ellsworth, Darrell L.; Weyandt, Jamie; Patney, Heather L.] Windber Rsch Inst, Windber, PA USA. [Love, Brad] Invitrogen, Carlsbad, CA USA. [Burke, Amy; Haberkorn, Mary Jane; Neatrour, David M.] Windber Med Cntr, Windber, PA USA. [Vernalis, Marina N.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD MAR 18 PY 2008 VL 117 IS 11 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 275IN UT WOS:000254065200096 ER PT J AU Adam, GE Carter, R Cheuvront, SN Merullo, DJ Castellani, JW Lieberman, HR Sawka, MN AF Adam, Gina E. Carter, Robert, III Cheuvront, Samuel N. Merullo, Donna J. Castellani, John W. Lieberman, Harris R. Sawka, Michael N. TI Hydration effects on cognitive performance during military tasks in temperate and cold environments SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE hypohydration; cold air exposure; cognitive performance; marksmanship; mood ID MODERATE COLD; MENTAL PERFORMANCE; HEAT-STRESS; EXERCISE PERFORMANCE; INDUCED DEHYDRATION; REACTION-TIME; EXPOSURE; THERMOREGULATION; HYPOHYDRATION; BODY AB Body water deficits or hypohydration (HYP) may degrade cognitive performance during heat exposure and perhaps temperate conditions. Cold exposure often induces HYP, but the combined effects of cold and HYP on cognitive performance are unknown. This study investigated whether HYP degrades cognitive performance during cold exposure and if physical exercise could mitigate any cold-induced performance decline. On four occasions, eight volunteers completed one hour of militarily-relevant cognitive testing: 30 min of simulated sentry duty/marksmanship, 20 min of a visual vigilance task, a self-report workload assessment, and a mood questionnaire. Testing was conducted in a cold (2 degrees C) or temperate (20 degrees C) environment before and after cycle ergometer (60 min at 60% of VO2peak) exercise. Each trial was preceded by 3 h of passive heat stress (45 'C) in the early morning with (euhydration, EUH) or without (hypohydration, HYP; 3% body mass) fluid replacement followed by prolonged recovery. HYP did not alter any cognitive, psychomotor, or self-report parameter in either environment before or after exercise. Cold exposure increased (p< 0.05) target detection latency in the sentry duty task, adversely affected mood and workload ratings, but had no impact on any other cognitive or psychomotor measure. After completing the exercise bout, there were modest improvements in friend-foe discrimination and total response latency in the sentry duty task, but not on any other performance measures. Moderate HYP had no effect on cognitive and psychomotor performance in either environment, cold exposure produced equivocal effects, and aerobic exercise improved some aspects of military task performance. Published by Elsevier Inc. C1 [Adam, Gina E.; Cheuvront, Samuel N.; Merullo, Donna J.; Castellani, John W.; Lieberman, Harris R.; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Carter, Robert, III] Ctr Rech Serv Sante Armees, F-38702 La Tronche, France. RP Adam, GE (reprint author), Kansas St,Bldg 42, Natick, MA 01760 USA. EM gina.e.adam@us.army.mil NR 43 TC 25 Z9 26 U1 3 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD MAR 18 PY 2008 VL 93 IS 4-5 BP 748 EP 756 DI 10.1016/j.physbeh.2007.11.028 PG 9 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA 293BZ UT WOS:000255311100011 PM 18166204 ER PT J AU Kim, JH Chen, MK Yang, CE Lee, J Yin, S Ruffin, P Edwards, E Brantley, C Luo, C AF Kim, Jae Hun Chen, Meng-Ku Yang, Chia-En Lee, Jon Yin, Stuart (Shizhuo) Ruffin, Paul Edwards, Eugene Brantley, Christina Luo, Claire TI Broadband IR supercontinuum generation using single crystal sapphire fibers SO OPTICS EXPRESS LA English DT Article ID MICROSTRUCTURED OPTICAL-FIBERS; ZBLAN FLUORIDE FIBERS; COHERENCE TOMOGRAPHY; CONTINUUM GENERATION; MU-M; SILICA; DISPERSION; RADIATION; LASER; NM AB In this paper, an investigation on broadband IR supercontinuum generation in single crystal sapphire fibers is presented. It is experimentally demonstrated that broadband IR supercontinuum spectrum (up to 3.2 mu m) can be achieved by launching ultra-short femtosecond laser pulses into single crystal sapphire fiber with a dimension 115 mu m in diameter and 5cm in length, which covers both the near IR spectral region and the lower end of the mid-IR spectral range. Furthermore, the mechanism of supercontinuum generation in single crystal sapphire fibers is briefly addressed. When the fiber length is shorter than the dispersion length, the self-phase modulation dominates the broadening effect. In this case, the broad supercontinuum spectrum with a smooth profile can be obtained. However, when the fiber length is longer than the dispersion length, the soliton-related dynamics accompanied by the self-phase modulation dominates the broadening effect. There are discrete spikes in the spectrum (corresponding to different order solitons). The above assumption of supercontinuum generation mechanism is quantitatively modeled by the computer simulation program and verified by the experimental results. Thus, one can adjust the spectral profile by properly choosing the length of the sapphire fibers. The broad IR spectral nature of this supercontinuum source can be very useful in a variety of applications such as broadband LADAR, remote sensing, and multi-spectrum free space communications. (C) 2008 Optical Society of America. C1 [Kim, Jae Hun; Chen, Meng-Ku; Yang, Chia-En; Lee, Jon; Yin, Stuart (Shizhuo)] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Ruffin, Paul; Edwards, Eugene; Brantley, Christina] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. [Luo, Claire] Gen Opto Solut, LLC, State Coll, PA 16803 USA. RP Yin, S (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu OI Kim, Jae-Hun/0000-0001-6537-0350 NR 35 TC 24 Z9 24 U1 1 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAR 17 PY 2008 VL 16 IS 6 BP 4085 EP 4093 DI 10.1364/OE.16.004085 PG 9 WC Optics SC Optics GA 276DL UT WOS:000254121400066 PM 18542506 ER PT J AU Wang, G Gertner, G Anderson, AB Howard, H AF Wang, G. Gertner, G. Anderson, A. B. Howard, H. TI Repeated measurements on permanent plots using local variability sampling for monitoring soil cover SO CATENA LA English DT Article DE remote sensing; sampling design; soil erosion cover factor; spatial variability ID CONSTRAINED OPTIMIZATION; REGIONALIZED VARIABLES; OPTIMAL INTERPOLATION; VEGETATION COVER; DESIGN; STRATEGIES; SCHEMES; PROGRAM; IMAGES AB On US military installations, training activities Such as vehicle use disturb ground and vegetation cover of landscapes, and increase potential rainfall runoff and soil erosion. In order to sustain training lands, soil erosion is of major concern. Thus there is a need for sampling designs to monitor degradation and recovery of land conditions. Traditionally, permanent plots are used to obtain the change of land conditions. However, the permanent plots often provide less information over time in characterizing the land conditions because of the fixed number and locations of plots. In this paper, we analyzed the sufficiency of a permanent plot sample and developed a method to improve the re-measurements of the permanent plots over time for a monitoring system of soil erosion based on spatial and temporal variability of a random function. We first applied a local variability based sampling method to generate reference samples that have sampling distances varying spatially and temporally to monitor a soil erosion relevant cover factor for an installation, Fort Riley, USA. Then, we compared a permanent sample with the reference samples annually over 13 years to determine additional sampling in the areas with high variability and temporarily suspending measurements of the permanent plots in the areas with low variability. The local variability based sampling provides estimates of local variability of the cover factor and thus is more cost-efficient than random sampling. By comparison with a reference samples, the re-measurements obtained should more accurately characterize the dynamics of the land conditions. (C) 2007 Elsevier B.V. All rights reserved. C1 [Wang, G.; Gertner, G.] Univ Illinois, Urbana, IL 61801 USA. [Anderson, A. B.; Howard, H.] US Army Corps Engineers, CERL, Champaign, IL USA. RP Gertner, G (reprint author), Univ Illinois, W503 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. EM gertner@uiuc.edu NR 35 TC 5 Z9 5 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0341-8162 J9 CATENA JI Catena PD MAR 15 PY 2008 VL 73 IS 1 BP 75 EP 88 DI 10.1016/j.catena.2007.09.005 PG 14 WC Geosciences, Multidisciplinary; Soil Science; Water Resources SC Geology; Agriculture; Water Resources GA 286ES UT WOS:000254829300007 ER PT J AU Bradfute, SB Warfield, KL Bavari, S AF Bradfute, Steven B. Warfield, Kelly L. Bavari, Sina TI Functional CD8(+) T cell responses in lethal Ebola virus infection SO JOURNAL OF IMMUNOLOGY LA English DT Article ID ACUTE RESPIRATORY SYNDROME; A H5N1 VIRUS; HEMORRHAGIC-FEVER; DENDRITIC CELLS; MARBURG VIRUSES; CYNOMOLGUS MACAQUES; NONHUMAN-PRIMATES; ZAIRE VIRUS; MOUSE MODEL; GUINEA-PIGS AB Ebola virus (EBOV) causes highly lethal hemorrhagic fever that leads to death in up to 90% of infected humans. Like many other infections, EBOV induces massive lymphocyte apoptosis, which is thought to prevent the development of a functional adaptive immune response. In a lethal mouse model of EBOV infection, we show that there is an increase in expression of the activation/ maturation marker CD44 in CD4(+) and CD8(+) T cells late in infection, preceding a dramatic rebound of lymphocyte numbers in the blood. Furthermore, we observed both lymphoblasts and apoptotic lymphocytes in spleen late in infection, suggesting that there is lymphocyte activation despite substantial bystander apoptosis. To test whether these activated lymphocytes were functional, we performed adoptive transfer studies. Whole splenocytes from moribund day 7 EBOV-infected animals protected naive animals from EBOV, but not Marburgvirus, challenge. In addition, we observed EBOV-specific CD8(+) T cell IFN-gamma responses in moribund day 7 EBOV-infected mice, and adoptive transfer of CD8(+) T cells alone from day 7 mice could confer protection to EBOV-challenged naive mice. Furthermore, CD8(+) cells from day 7, but not day 0, mice proliferated after transfer to infected recipients. Therefore, despite significant lymphocyte apoptosis, a functional and specific, albeit insufficient, adaptive immune response is made in lethal EBOV infection and is protective upon transfer to naive infected recipients. These findings should cause a change in the current view of the 'impaired' immune response to EBOV challenge and may help spark new therapeutic strategies to control lethal filovirus disease. C1 [Bradfute, Steven B.; Warfield, Kelly L.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM sina.bavari@amedd.army.mil NR 44 TC 45 Z9 45 U1 0 U2 9 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAR 15 PY 2008 VL 180 IS 6 BP 4058 EP 4066 PG 9 WC Immunology SC Immunology GA 324GS UT WOS:000257506600053 PM 18322215 ER PT J AU Castellanos-Gonzalez, A Yancey, LS Wang, HC Pantenburg, B Liscum, KR Lewis, DE White, AC AF Castellanos-Gonzalez, Alejandro Yancey, Linda S. Wang, Heuy-Ching Pantenburg, Birte Liscum, Kathleen R. Lewis, Dorothy E. White, A. Clinton, Jr. TI Cryptosporidium infection of human intestinal epithelial cells increases expression of osteoprotegerin: A novel mechanism for evasion of host defenses SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 55th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 11-16, 2006 CL Atlanta, GA SP Amer Soc Trop Med & Hyg ID PROBE LEVEL DATA; PARVUM INFECTION; IN-VITRO; CRYPTOSPOTIDIUM-PARVUM; KAPPA-B; APOPTOSIS; DISEASE; MICE; NORMALIZATION; SUMMARIES AB Cryptosporidium parasites are pathogens of human intestinal epithelial cells. To determine which genes are regulated during early infection, human ileal mucosa cultured as explants was infected with C. parvum or C. hominis, and gene expression was analyzed by microarray. The gene for osteoprotegerin (OPG) was up-regulated by both parasites. OPG mRNA was also significantly increased in biopsy specimens obtained from a volunteer experimentally infected with C. meleagridis, compared with levels in a prechallenge biopsy specimen. After in vitro infection of HCT-8 cells, there was an early peak in production of OPG mRNA protein. Treatment of infected cells with the OPG ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced epithelial cell apoptosis and reduced parasite numbers, and recombinant OPG blocked these effects. These results suggest a novel TRAIL-mediated pathway for elimination of Cryptosporidium infection and a role for OPG in modulating this host response. C1 [Castellanos-Gonzalez, Alejandro; Pantenburg, Birte; White, A. Clinton, Jr.] Univ Texas Galveston, Dept Internal Med, Div Infect Dis, Med Branch, Galveston, TX 77555 USA. [Castellanos-Gonzalez, Alejandro; Yancey, Linda S.; Wang, Heuy-Ching; Pantenburg, Birte; White, A. Clinton, Jr.] Baylor Coll Med, Dept Med, Infect Dis Sect, Houston, TX 77030 USA. [Liscum, Kathleen R.] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA. [Lewis, Dorothy E.] Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA. [Wang, Heuy-Ching] US Army Med Res Detachment, Walter Reed Army Inst Res, Brooks AFB, TX USA. RP White, AC (reprint author), Univ Texas Galveston, Dept Internal Med, Div Infect Dis, Med Branch, 301 Univ Blvd,Rt 0435, Galveston, TX 77555 USA. EM acwhite@utmb.edu OI White, A Clinton/0000-0002-9668-4632 FU NIAID NIH HHS [R01 AI0417351] NR 35 TC 16 Z9 18 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR 15 PY 2008 VL 197 IS 6 BP 916 EP 923 DI 10.1086/528374 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 271FI UT WOS:000253773900019 PM 18288900 ER PT J AU Fernandes, GE Guyot, L Chern, GD Kneissl, M Johnson, NM Song, Q Xu, L Chang, RK AF Fernandes, Gustavo E. Guyot, Laurent Chern, Grace D. Kneissl, Michael Johnson, Noble M. Song, Qinghai Xu, Lei Chang, Richard K. TI Wavelength and intensity switching in directly coupled semiconductor microdisk lasers SO OPTICS LETTERS LA English DT Article ID CAVITY AB We demonstrate output wavelength and intensity switching in a three-element directly coupled microdisk device consisting of one spiral microdisk coupled to two semicircle microdisks. The gapless coupling mechanism used allows individual elements to achieve lasing while achieving optimal transfer of optical power between adjacent microdisks. By controlling the transparency of the center element via injection current, the edge elements can be allowed to exchange their amplified spontaneous emission. In this manner, on-off-on switching of the output intensity, as well as discontinuous shifts in the output wavelength, can be achieved as a function of increasing injection current. (C) 2008 Optical Society of America. C1 [Fernandes, Gustavo E.; Guyot, Laurent; Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06511 USA. [Fernandes, Gustavo E.; Guyot, Laurent; Chang, Richard K.] Yale Univ, Ctr Laser Diagnost, New Haven, CT 06511 USA. [Chern, Grace D.] US Army Res Lab, Adelphi, MD 20783 USA. [Kneissl, Michael] Tech Univ Berlin, Inst Solid State Phys, D-10623 Berlin, Germany. [Johnson, Noble M.] PARC, Palo Alto, CA 94304 USA. [Song, Qinghai; Xu, Lei] Fudan Univ, Dept Opt Sci & Engn, Shanghai 2004333, Peoples R China. RP Fernandes, GE (reprint author), Yale Univ, Dept Appl Phys, New Haven, CT 06511 USA. EM gustavo.fernandes@yale.edu RI Song, Qinghai/C-2197-2014; Kneissl, Michael/B-9682-2012 NR 12 TC 8 Z9 8 U1 2 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD MAR 15 PY 2008 VL 33 IS 6 BP 605 EP 607 DI 10.1364/OL.33.000605 PG 3 WC Optics SC Optics GA 287HI UT WOS:000254907500025 PM 18347724 ER PT J AU Bansal, NP Zhu, DM AF Bansal, Narottam P. Zhu, Dongming TI Thermal properties of oxides with magnetoplumbite structure for advanced thermal barrier coatings SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE magnetoplumbite oxides; thermal conductivity; thermal expansion; thermal barrier coatings; doping ID LANTHANUM HEXAALUMINATE; CONDUCTIVITY AB Oxides having magnetoplumbite structure are promising candidate materials for applications as high temperature thermal barrier coatings because of their high thermal stability, high thermal expansion, and low thermal conductivity. In this study, powders of LaMgAl11O19, GdMgAl11O19, SmMgAl11O19, and Gd0.7Yb0.3MgAl11O19 magnetoplumbite oxides were synthesized by citric acid sol-gel method and hot-pressed into disk specimens. The thermal expansion coefficients (CTE) of these oxide materials were measured from room temperature to 1500 degrees C. The average CTE value was found to be similar to 9.6 x 10(-6)/C. Thermal conductivity of these magnetoplumbite-based oxide materials was also evaluated using steady-state laser heat flux test method. The effects of doping on thermal properties were also examined. Thermal conductivity of the doped Gd0.7Yb0.3MgAl11O19 composition was found to be lower than that of the undoped GdMgAl11O19. In contrast, thermal expansion coefficient was found to be independent of the oxide composition and appears to be controlled by the magnetoplumbite crystal structure. Preliminary results of thermal conductivity testing at 1600 degrees C for LaMgAl11O19 and LaMnAl11O19 magnetoplumbite oxide coatings plasma-sprayed on NiCrAlY/Rene N5 superalloy substrates are also presented. The plasma-sprayed coatings did not sinter even. at temperatures as high as 1600 degrees C. Published by Elsevier B.V. C1 NASA, Glenn Res Ctr, Struct & Mat Div, Cleveland, OH 44135 USA. [Zhu, Dongming] Glenn Res Ctr, US Army Lab, Vehicle Technol Directorate, Cleveland, OH 44135 USA. RP Bansal, NP (reprint author), NASA, Glenn Res Ctr, Struct & Mat Div, Cleveland, OH 44135 USA. EM Narottam.P.Bansal@nasa.gov NR 15 TC 56 Z9 64 U1 2 U2 40 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD MAR 15 PY 2008 VL 202 IS 12 BP 2698 EP 2703 DI 10.1016/j.surfcoat.2007.09.048 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 279PT UT WOS:000254367800025 ER PT J AU Mendez, S Hatem, CL Kesavan, AK Lopez-Molina, J Pitt, MLM Dannenberg, AM Manabe, YC AF Mendez, Susana Hatem, Christine L. Kesavan, Anup K. Lopez-Molina, Javier Pitt, M. Louise M. Dannenberg, Arthur M., Jr. Manabe, Yukari C. TI Susceptibility to tuberculosis: Composition of tuberculous granulomas in Thorbecke and outbred New Zealand White rabbits SO VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article DE tuberculosis; rabbit; host susceptibility; animal model; dendritic cell ID MYCOBACTERIUM-TUBERCULOSIS; T-LYMPHOCYTES; GUINEA-PIGS; MICE; RESISTANCE; DISEASE AB We sought to characterize the lung cellular immune responses to inhaled Mycobacterium tuberculosis (Mtb) of the susceptible inbred Thorbecke rabbit (the genomically sequenced strain, now unavailable) and compare it to outbred, Mtb-resistant, New Zealand White rabbits. Using Mtb CDC1551, we confirmed that the inbred rabbits allowed establishment of infection with this low virulence strain, compared to poor establishment in outbred rabbits. With a more virulent strain, Mtb Erdman, that establishes infection well in both rabbit strains, we analyzed granulomas from rabbit lungs 5 weeks after aerosol infection. The lung granulomas of inbred rabbits had significantly higher frequencies of cells expressing MHC Class II and CD11b, and lower frequencies of CD8+ T cells than the outbred controls. Macrophage-sized cells expressing MHC Class II in inbred rabbit granulomas showed significantly decreased intensity of expression, suggesting impaired maturation. Although the inbred dermal tuberculin reactions were decreased, the in vitro IFN-gamma mRNA responses of hilar node lymphocytes to tuberculin were higher than those of outbred rabbits. Further delineation of the outbred rabbit's resistant immune response to Mtb infection is warranted. (C) 2007 Elsevier B.V. All rights reserved. C1 [Hatem, Christine L.; Kesavan, Anup K.; Lopez-Molina, Javier; Manabe, Yukari C.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Mendez, Susana] Cornell Vet Coll, James A Baker Inst Anim Hlth, Ithaca, NY 14853 USA. [Mendez, Susana; Hatem, Christine L.; Kesavan, Anup K.; Lopez-Molina, Javier; Pitt, M. Louise M.; Dannenberg, Arthur M., Jr.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Environm Hlth, Baltimore, MD 21205 USA. [Dannenberg, Arthur M., Jr.; Manabe, Yukari C.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA. [Dannenberg, Arthur M., Jr.; Manabe, Yukari C.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. [Pitt, M. Louise M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Manabe, YC (reprint author), Johns Hopkins Univ, Sch Med, Dept Med, 720 Rutland St,Room 1147B, Baltimore, MD 21205 USA. EM ymanabe@jhmi.edu FU NHLBI NIH HHS [1R01 HL71554, R01 HL071554, R01 HL071554-05] NR 16 TC 8 Z9 10 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2427 J9 VET IMMUNOL IMMUNOP JI Vet. Immunol. Immunopathol. PD MAR 15 PY 2008 VL 122 IS 1-2 BP 167 EP 174 DI 10.1016/j.vetimm.2007.11.006 PG 8 WC Immunology; Veterinary Sciences SC Immunology; Veterinary Sciences GA 285GT UT WOS:000254766000019 PM 18155300 ER PT J AU Angelo, G Lamon-Fava, S Sonna, LA Lindauer, ML Wood, RJ AF Angelo, Giana Lamon-Fava, Stefania Sonna, Larry A. Lindauer, Meghan L. Wood, Richard J. TI Heat shock protein 90 beta: A novel mediator of vitamin D action SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE heat shock protein 90; Hsp90 beta; vitamin D; vitamin D receptor; steroid hormone; Caco-2 ID HEAT-SHOCK-PROTEIN; D-RECEPTOR; CALCIUM-ABSORPTION; CHAPERONE; HSP90; EXPRESSION; TRANSACTIVATION; ASSOCIATION; FAMILY; CELLS AB We investigated the role of Heat shock protein 90 (Hsp90) in vitamin D action in Caco-2 cells using geldanamycin (GA) to block Hsp90 function and RNA interference to reduce Hsp90 beta expression. When cells were exposed to GA, vitamin D-mediated gene expression and transcriptional activity were inhibited by 69% and 54%, respectively. Gel shift analysis indicated that GA reduced vitamin D-mediated DNA binding activity of the vitamin D receptor (VDR). We tested the specific role of Hsp90 beta by knocking down its expression with stably expressed short hairpin RNA. Vitamin D-induced gene expression and transcriptional activity were reduced by 90% and 80%, respectively, in Hsp90 beta-deficient cells. Nuclear protein for VDR and RXR alpha, its heterodimer partner, were not reduced in Hsp90 beta-deficient cells, These findings indicate that Hsp90 beta is needed for optimal vitamin D responsiveness in the enterocyte and demonstrate a specific role for Hsp90 beta in VDR signaling. (C) 2008 Elsevier Inc. All rights reserved. C1 [Angelo, Giana; Lamon-Fava, Stefania; Lindauer, Meghan L.; Wood, Richard J.] Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Min Bioavailabil Lab, Boston, MA 02111 USA. [Angelo, Giana; Lindauer, Meghan L.; Wood, Richard J.] Min Bioavailabil Lab, Boston, MA 02111 USA. [Lamon-Fava, Stefania] Lipid Metabol Lab, Boston, MA 02111 USA. [Sonna, Larry A.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Sonna, Larry A.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Pulm & Crit Care Med, Boston, MA 02115 USA. RP Angelo, G (reprint author), Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N B2-152, Seattle, WA 98109 USA. EM gangelo@fbcrc.org NR 28 TC 18 Z9 18 U1 1 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD MAR 14 PY 2008 VL 367 IS 3 BP 578 EP 583 DI 10.1016/j.bbrc.2007.12.179 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 260LY UT WOS:000253013000011 PM 18182164 ER PT J AU He, H Scheicher, RH Pandey, R Rocha, AR Sanvito, S Grigoriev, A Ahuja, R Karna, SP AF He, Haiying Scheicher, Ralph H. Pandey, Ravindra Rocha, Alexandre Reily Sanvito, Stefano Grigoriev, Anton Ahuja, Rajeev Karna, Shashi P. TI Functionalized nanopore-embedded electrodes for rapid DNA sequencing SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID SINGLE NUCLEOTIDE POLYMORPHISMS; SOLID-STATE NANOPORE; POLYNUCLEOTIDE MOLECULES; DISCRIMINATION; TRANSPORT; TECHNOLOGIES; MEDICINE; BIOLOGY; ACID AB With the aim of improving nanopore-based DNA sequencing, we explored the effects of functionalizing the embedded gold electrodes with purine and pyrimidine molecules. Hydrogen bonds formed between the molecular probe and target bases stabilize the scanned DNA unit against thermal fluctuations and thus greatly reduce noise in the current signal. The results of our first-principles study indicate that this proposed scheme could allow DNA sequencing with a robust and reliable yield, producing current signals that differ by at least 1 order of magnitude for the different bases. C1 [Scheicher, Ralph H.; Grigoriev, Anton; Ahuja, Rajeev] Uppsala Univ, CMT Grp, Dept Phys, Uppsala, Sweden. [He, Haiying; Scheicher, Ralph H.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [He, Haiying; Scheicher, Ralph H.; Pandey, Ravindra] Michigan Technol Univ, Multi Scale Technol Inst, Houghton, MI 49931 USA. [Rocha, Alexandre Reily; Sanvito, Stefano] Trinity Coll Dublin, Sch Phys, Dublin 2, Ireland. [Rocha, Alexandre Reily; Sanvito, Stefano] Trinity Coll Dublin, CRANN, Dublin 2, Ireland. [Karna, Shashi P.] USA, Res Lab, Weapons & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA. RP Scheicher, RH (reprint author), Uppsala Univ, CMT Grp, Dept Phys, Box 530, Uppsala, Sweden. EM rhs@mtu.edu; pandey@mtu.edu RI Pandey, Ravi/A-8759-2009; Rocha, Alexandre/F-9504-2010; Scheicher, Ralph/G-1740-2012; Grigoriev, Anton/A-9116-2013 OI Rocha, Alexandre/0000-0001-8874-6947; Grigoriev, Anton/0000-0001-5389-2469 NR 27 TC 43 Z9 45 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAR 13 PY 2008 VL 112 IS 10 BP 3456 EP 3459 DI 10.1021/jp7115142 PG 4 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 271JJ UT WOS:000253784400002 ER PT J AU Alving, CR AF Alving, Carl R. TI 4E10 and 2F5 monoclonal antibodies: binding specificities to phospholipids, tolerance, and clinical safety issues SO AIDS LA English DT Editorial Material ID ANTIPHOSPHOLIPID ANTIBODIES; NATURAL AUTOANTIBODIES; HIV-ANTIBODIES; AUTOREACTIVITY; LIPOSOMES C1 US Mil HIV Res Program, Walter Reed Army Inst Res, Div Retrovirol, Dept Adjuvant & Antigen Res, Rockville, MD 20850 USA. RP Alving, CR (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, Div Retrovirol, Dept Adjuvant & Antigen Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM calving@hivresearch.com NR 21 TC 15 Z9 15 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD MAR 12 PY 2008 VL 22 IS 5 BP 649 EP 651 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 284AE UT WOS:000254676800013 PM 18317008 ER PT J AU Romick, BG McGlasson, DL Rubal, BJ Hall, W AF Romick, Benjamin G. McGlasson, David L. Rubal, Bernard J. Hall, Wilford TI Comparison of a chromogenic factor X assay to international normalized ratio for monitoring oral anticoagulation therapy SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 57th Annual Scientific Session of the American-College-of-Cardiology CY MAR 29-APR 01, 2008 CL Chicago, IL SP Amer Coll Cardiol C1 USAF, Med Ctr, Lackland AFB, TX USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 11 PY 2008 VL 51 IS 10 SU A BP A282 EP A282 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 274JH UT WOS:000253997102115 ER PT J AU Trichy, GR Chakraborti, D Narayan, J Prater, JT AF Trichy, G. R. Chakraborti, D. Narayan, J. Prater, J. T. TI Structure-magnetic property correlations in the epitaxial FePt system SO APPLIED PHYSICS LETTERS LA English DT Article ID NANOPARTICLES AB We present findings on the effect of microstructure on magnetic properties of the epitaxial FePt system. Epitaxial c-axis oriented FePt was synthesized on Si (100) using TiN as a template buffer. The microstructure was progressively varied from a 9 nm nanoparticle system to a 30 nm thick continuous thin film. We found that individual nanoparticles showed higher coercivity than the continuous thin film. Within the nanoparticle regime, coercivity increased with increasing particle size. The highest coercivity of 13 500 Oe was realized for a beadlike microstructure, when the individual nanoparticles just begin to merge to form a continuous thin film. (c) 2008 American Institute of Physics. C1 [Trichy, G. R.; Chakraborti, D.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, J. T.] USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Trichy, GR (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM gtrichy@gmail.com RI Narayan, Jagdish/D-1874-2009 NR 12 TC 35 Z9 35 U1 0 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 10 PY 2008 VL 92 IS 10 AR 102504 DI 10.1063/1.2883933 PG 3 WC Physics, Applied SC Physics GA 274GH UT WOS:000253989300079 ER PT J AU Turbyfill, KR Kaminski, RW Oaks, EV AF Turbyfill, K. Ross Kaminski, Robert W. Oaks, Edwin V. TI Immunogenicity and efficacy of highly purified invasin complex vaccine from Shigella flexneri 2a SO VACCINE LA English DT Article DE Shigella vaccine; invasin complex; IpaB; IpaC; LIPS ID PLASMID ANTIGENS IPAB; MEMBRANE-VESICLES; LIPOPOLYSACCHARIDE VACCINES; MONOCLONAL-ANTIBODIES; MAMMALIAN-CELLS; MODEL; INTRANASAL; SECRETION; INFECTION; VIRULENCE AB Development of a subunit vaccine for shigellosis requires identification of protective antigens and delivering these antigens in a manner that stimulates immunity comparable to that induced by natural infection. The Shigella invasin complex (Invaplex) vaccine is an ion -exchange- purified extract from virulent Shigella that consists of LIPS and several other proteins, including the invasins IpaB and IpaC. Intranasal delivery of Invaplex stimulates protective immunity in small animal models for shigellosis. To identify the active component(s) of Invaplex responsible for its immunogenicity and efficacy, size-exclusion chromatography (SEC) was used to separate Invaplex into several. different fractions. A high-molecular mass complex with a molecular mass between 669MDa and 2MDa consisted primarily of LPS, IpaB and lpaC and was considered to be a highly purified (HP) form of Invaplex. Using the mouse lung model to evaluate the immunogenicity and efficacy of the SEC fractions it was clearLy demonstrated that the high-molecular mass complex of the invasins and LIPS was responsible for the protective capacity of parent native Invaplex. Other smaller mass SEC fractions were mostly non-immunogenic and did not stimulate solid protection. In guinea pigs, the HP Invaplex stimulated an enhanced immune response as compared to the parent Invaplex and was fully protective. Isolation and characterization of the immunogenic and protective moiety within Invaplex will. allow better standardization of the Invaplex product and may allow future development of an Invaplex assembled from purified components. Published by Elsevier Ltd. C1 [Turbyfill, K. Ross; Kaminski, Robert W.; Oaks, Edwin V.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Oaks, EV (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Edwin.oaks@na.amedd.army.mil NR 32 TC 22 Z9 22 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 4 PY 2008 VL 26 IS 10 BP 1353 EP 1364 DI 10.1016/j.vaccine.2007.12.040 PG 12 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 284QT UT WOS:000254721600010 PM 18276045 ER PT J AU Zhao, P Woolard, DL AF Zhao, Peiji Woolard, Dwight L. TI Electron-longitudinal-acoustic-phonon scattering in double-quantum-dot based quantum gates SO PHYSICS LETTERS A LA English DT Article DE electron-phonon scattering; quantum gates; double quantum dots; decoherence ID SUPPRESSION; SYSTEMS AB We propose a nanostructure design which can significantly suppress longitudinal-acoustic-phonon-electron scattering in double-quantum-dot based quantum gates for quantum computing. The calculated relaxation rates vs. bias voltage exhibit a double-peak feature with a minimum approaching 10(5) s(-1). In this matter, the energy conservation law prohibits scattering contributions from phonons with large momenta; furthermore, increasing the barrier height between the double quantum dots reduces coupling strength between the dots. Hence, the joint action of the energy conservation law and the decoupling greatly reduces the scattering rates. The degrading effects of temperatures can be reduced simply by increasing the height of the barrier between the dots. (C) 2007 Elsevier B.V. All rights reserved. C1 [Zhao, Peiji] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Woolard, Dwight L.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Zhao, P (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM pzhao@eos.ncsu.edu NR 22 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9601 J9 PHYS LETT A JI Phys. Lett. A PD MAR 3 PY 2008 VL 372 IS 10 BP 1666 EP 1670 DI 10.1016/j.physleta.2007.10.013 PG 5 WC Physics, Multidisciplinary SC Physics GA 274WQ UT WOS:000254033900021 ER PT J AU Katritzky, AR Vakulenko, AV Sivapackiam, J Draghici, B Damavarapu, R AF Katritzky, Alan R. Vakulenko, Anatoliy V. Sivapackiam, Jothilingam Draghici, Bogdan Damavarapu, Reddy TI Synthesis of dinitro-substituted furans, thiophenes, and azoles SO SYNTHESIS-STUTTGART LA English DT Article DE dinitrofurans; dinitrothiophenes; dinitroazoles; nitration; oxidation ID PRELIMINARY BIOLOGICAL EVALUATION; ELECTROPHILIC SUBSTITUTION; TUMOR HYPOXIA; NITRATION; HETEROCYCLES; DERIVATIVES; RESONANCE; OXIDATION; PYRAZOLES; SPECTRA AB Direct nitration of the corresponding mononitro furans with fuming nitric acid, thiophenes with acetyl nitrate, and thiazoles with trifluoroacetyl nitrate, gave dinitro-substituted furans, thiophenes, and thiazoles. The nitrations of 2-alkylthiophenes with 3 and 5 molar equivalents of acetyl nitrate, generated in situ, are discussed. Reactions of the mononitro furans with fuming nitric acid gave 1,1,5,5-tetrasubstituted dihydrofurans as by-products. Treatment of 5-methyl-4-nitroisoxazole with hydrazine or its methyl or phenyl derivative, followed by oxidation of the corresponding 4amino-5-nitro-1H-pyrazoles with hydrogen peroxide (50%) gave 4,5-dinitro-1H-pyrazoles. A safe one-pot synthesis of 1-alkyl-3,5-dinitro-1H-[1,2,4]triazoles was developed from dicyandiamide. C1 [Katritzky, Alan R.; Vakulenko, Anatoliy V.; Sivapackiam, Jothilingam; Draghici, Bogdan] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA. [Damavarapu, Reddy] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Katritzky, AR (reprint author), Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA. EM katritzky@chem.ufl.edu RI SIVAPACKIAM, JOTHILINGAM/G-3939-2011; Draghici, Bogdan/H-5526-2013; Sivapackiam, Jothilingam/O-9387-2014 OI SIVAPACKIAM, JOTHILINGAM/0000-0002-5778-8025; Draghici, Bogdan/0000-0002-3792-5002; Sivapackiam, Jothilingam/0000-0001-7979-1893 NR 64 TC 13 Z9 13 U1 0 U2 8 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0039-7881 J9 SYNTHESIS-STUTTGART JI Synthesis PD MAR 3 PY 2008 IS 5 BP 699 EP 706 DI 10.1055/s-2008-1032187 PG 8 WC Chemistry, Organic SC Chemistry GA 277CC UT WOS:000254189300005 ER PT J AU Cooper, GR AF Cooper, G. R. TI Spinning projectile with an inviscid liquid payload impregnating porous media SO AIAA JOURNAL LA English DT Article C1 [Cooper, G. R.] USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Cooper, GR (reprint author), USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 12 TC 4 Z9 5 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 J9 AIAA J JI AIAA J. PD MAR PY 2008 VL 46 IS 3 BP 783 EP 787 DI 10.2514/1.30481 PG 5 WC Engineering, Aerospace SC Engineering GA 266AL UT WOS:000253403200023 ER PT J AU Bautista, CT Mosquera, C Serra, M Gianella, A Avila, MM Laguna-Torres, V Carr, JK Montano, SM Sanchez, JL AF Bautista, Christian T. Mosquera, Carlos Serra, Margarita Gianella, Alberto Avila, Maria M. Laguna-Torres, Victor Carr, Jean K. Montano, Silvia M. Sanchez, Jose L. TI Immigration status and HIV-risk related behaviors among female sex workers in South America SO AIDS AND BEHAVIOR LA English DT Article DE female; immigrant; migrant; behavior; FSW; HIV ID MIGRANT WORKERS; PROSTITUTION; INFECTION; SYDNEY AB This study compares immigrant (i.e., foreigner) with non-immigrant (i.e., local/native) HIV-related risk behaviors among female sex workers (FSW) in South America. A total of 1,845 FSW were enrolled in Argentina, Bolivia, Ecuador, and Uruguay. According to their nationality, 10.1% of participants were immigrant FSW. Immigrant FSW were more likely to be younger in Argentina; to work in a disco/bar in Bolivia; to be single and use illegal drugs in Ecuador; and to work in a brothel, consume alcohol, and have sex with foreign clients in Uruguay. HIV-related sexual and drug use behaviors were more common among immigrant FSW in Bolivia, Ecuador, and Uruguay. Country-specific HIV/STI prevention and control programs should be developed for immigrant FSW populations in South America. C1 [Bautista, Christian T.] USA, Walter Reed Army Inst Res, Mil HIV Res Program, Rockville, MD 20850 USA. [Bautista, Christian T.; Laguna-Torres, Victor; Montano, Silvia M.] USN, Med Res Ctr Detachment, Lima, Peru. [Mosquera, Carlos] Inst Nacl Hig & Med Trop Leopoldo Izquieta Perez, Guayaquil, Ecuador. [Serra, Margarita] Minist Salud, VIH SIDA, Programa nacl Prevenc & Control, Montevideo, Uruguay. [Gianella, Alberto] CENETROP, Santa Cruz, CA USA. [Avila, Maria M.] Univ Buenos Aires, CNRS, Buenos Aires, DF, Argentina. [Carr, Jean K.] Inst Human Virol, Baltimore, MD USA. [Sanchez, Jose L.] DOD GEIS, Silver Spring, MD USA. [Bautista, Christian T.; Sanchez, Jose L.] Adv Mil Med Inc, Jackson Fdn, Rockville, MD USA. RP Bautista, CT (reprint author), USA, Walter Reed Army Inst Res, Mil HIV Res Program, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. EM cbautista@hivresearch.org RI Bautista, Christian/B-2812-2011 NR 24 TC 18 Z9 18 U1 0 U2 8 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS behav. PD MAR PY 2008 VL 12 IS 2 BP 195 EP 201 DI 10.1007/s10461-007-9270-3 PG 7 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 267QH UT WOS:000253523800003 PM 17587171 ER EF