FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Rickards, CA Ryan, KL Convertino, VA AF Rickards, Caroline A. Ryan, Kathy L. Convertino, Victor A. TI Tolerance to central hypovolemia: The influence of cerebral blood flow velocity oscillations SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Div Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2009 VL 23 MA 613.7 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V27OC UT WOS:000208621501421 ER PT J AU Ruff, AL Dillman, JF AF Ruff, Albert Leonard Dillman, James Franklin TI p38 MAPK Regulates Sulfur Mustard-Induced Cytokines Independent of NF-kappa B, and Does Not Regulate Sulfur Mustard-Induced Cell Death SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ruff, Albert Leonard; Dillman, James Franklin] USA, Med Res Insitute Chem Def, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2009 VL 23 MA 524.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V27OC UT WOS:000208621500071 ER PT J AU Ryan, KL Rickards, CA Convertino, VA AF Ryan, Kathy L. Rickards, Caroline A. Convertino, Victor A. TI ASSOCIATION OF ARTERIAL PRESSURE OSCILLATIONS WITH MUSCLE SYMPATHETIC NERVE ACTIVITY (MSNA) DURING CENTRAL HYPOVOLEMIA SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Ryan, Kathy L.; Rickards, Caroline A.; Convertino, Victor A.] USA, Inst Surg Res, Div Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2009 VL 23 MA 1019.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V27OC UT WOS:000208621501404 ER PT J AU Tierney, M Merritt, E Sarathy, A Walters, T Farrar, R AF Tierney, Matthew Merritt, Edward Sarathy, Apurva Walters, Thomas Farrar, Roger TI Identification of regenerating myofibers within an extracellular matrix seeded with bone marrow derived cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tierney, Matthew; Merritt, Edward; Sarathy, Apurva; Farrar, Roger] Univ Texas Austin, Austin, TX 78712 USA. [Walters, Thomas] USA, Soft Tissue Injury Lab, Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2009 VL 23 MA 467.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V27OC UT WOS:000208621506714 ER PT J AU Tierney, M Merritt, E Sarathy, A Walters, T Farrar, R AF Tierney, Matthew Merritt, Edward Sarathy, Apurva Walters, Thomas Farrar, Roger TI Identification of regenerating myofibers within an extracellular matrix seeded with bone marrow derived cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tierney, Matthew; Merritt, Edward; Sarathy, Apurva; Farrar, Roger] Univ Texas Austin, Austin, TX 78712 USA. [Walters, Thomas] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2009 VL 23 MA 467.5 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V27OC UT WOS:000208621506845 ER PT J AU Tong, L Januszkiewicz, AJ Swauger, PV de Lanerolle, NC Kim, JH Gyorgy, AB Agoston, DV Bandak, FA Ling, GS Parks, SA AF Tong, Lawrence Januszkiewicz, Adolph J. Swauger, Peter V. de Lanerolle, Nihal C. Kim, Jung H. Gyorgy, Andrea B. Agoston, Denes V. Bandak, Faris A. Ling, Geoffrey S. Parks, Steven A. TI Exposure of swine to nonpenetrating blast results in reactive astrogliosis, fiber degeneration, and upregulation of inflammatory markers SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Tong, Lawrence; Swauger, Peter V.; Parks, Steven A.] ORA Inc, Fredericksburg, VA USA. [Tong, Lawrence; Januszkiewicz, Adolph J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [de Lanerolle, Nihal C.; Kim, Jung H.] Yale Univ, Sch Med, New Haven, CT USA. [Gyorgy, Andrea B.; Agoston, Denes V.; Bandak, Faris A.; Ling, Geoffrey S.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Bandak, Faris A.] ISG Inc, Potomac, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2009 VL 23 MA 926.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V27OC UT WOS:000208621500850 ER PT J AU Uyehara, CFT Batts, SG Kinnison, MW McEntire, SP Sato, AK Ichimura, WM Hashiro, GM Hernandez, CA AF Uyehara, Catherine F. T. Batts, Sherreen G. Kinnison, Martin W. McEntire, Shane P. Sato, Aileen K. Ichimura, Wayne M. Hashiro, Glenn M. Hernandez, Claudia A. TI Vasopressin Regulation During Extracorporeal Membrane Oxygenation (ECMO) in a Pig Model of Septic Shock SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Uyehara, Catherine F. T.; Sato, Aileen K.; Ichimura, Wayne M.; Hashiro, Glenn M.; Hernandez, Claudia A.] Tripler Army Med Ctr, Dept Clin Invest, Tripler, HI USA. [Batts, Sherreen G.] Tripler Army Med Ctr, Dept Pediat, Tripler, HI USA. [Kinnison, Martin W.; McEntire, Shane P.] Tripler Army Med Ctr, Dept Surg, Tripler, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2009 VL 23 MA 605.1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V27OC UT WOS:000208621503625 ER PT J AU Wang, XE Stavchansky, S Bowman, P AF Wang, Xinyu Eric Stavchansky, Salomon Bowman, Phillip TI Cytoprotective effect of a synthetic triterpenoid against oxidative stress in human umbilical vein endothelial cells (HUVEC) SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Wang, Xinyu Eric; Bowman, Phillip] USA, Inst Surg Res, San Antonio, TX USA. [Wang, Xinyu Eric; Stavchansky, Salomon] Univ Texas Austin, Austin, TX 78712 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2009 VL 23 MA 937.7 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V27OC UT WOS:000208621501866 ER PT J AU Yang, J Kerwin, SM Wang, XY Stavchansky, S Bynum, J Bowman, P AF Yang, John Kerwin, Sean Michael Wang, Xinyu Stavchansky, Salomon Bynum, James Bowman, Phillip TI Structure activity relationships of caffeic acid phenethyl ester (CAPE) and its amide derivative caffeic acid phenethyl amide (CAPA) against oxidant stress in human endothelial cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 [Yang, John; Kerwin, Sean Michael; Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Austin, TX 78712 USA. [Bynum, James; Bowman, Phillip] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2009 VL 23 MA 937.8 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA V27OC UT WOS:000208621502506 ER PT J AU Levens, ED Whitcomb, BW Payson, MD Larsen, FW AF Levens, Eric D. Whitcomb, Brian W. Payson, Mark D. Larsen, Frederick W. TI Ovarian follicular flushing among low-responding patients undergoing assisted reproductive technology SO FERTILITY AND STERILITY LA English DT Article; Proceedings Paper CT 63rd Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 13-17, 2007 CL Washington, DC SP Amer Soc Reprod Med ID DIRECTED OOCYTE RECOVERY; ASPIRATION; ULTRASOUND; RETRIEVAL; FOLLICLES; NEEDLES AB A randomized comparison trial was performed to evaluate whether follicular reaspiration with use of a double-lumen retrieval needle improves oocyte recovery when compared with direct follicular aspiration among low-responding patients undergoing ART. There were no differences observed in the number of oocytes retrieved (single lumen: 6.5 +/- 2.2 oocytes, double lumen: 7.2 +/- 2.3 oocytes) whereas follicular reaspiration with the double-lumen retrieval needle resulted in a twofold increase in procedure time. (Fertil Steril (R) 2009;91: 1381-4. (C) 2009 by American Society for Reproductive Medicine.) C1 [Levens, Eric D.] NICHHD, NIH, Reprod Biol & Med Branch, Bethesda, MD 20892 USA. [Levens, Eric D.; Payson, Mark D.; Larsen, Frederick W.] Walter Reed Army Med Ctr, ART Program, Washington, DC 20307 USA. [Levens, Eric D.; Payson, Mark D.; Larsen, Frederick W.] NIH, Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD 20892 USA. [Levens, Eric D.; Payson, Mark D.; Larsen, Frederick W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Whitcomb, Brian W.] NICHHD, NIH, Epidemiol Branch, Bethesda, MD 20892 USA. RP Levens, ED (reprint author), NICHHD, NIH, Reprod Biol & Med Branch, Bldg 10,CRC,Room E1-3140,10 Ctr Dr, Bethesda, MD 20892 USA. EM levense@mail.nih.gov FU Intramural NIH HHS [Z99 HD999999] NR 14 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD APR PY 2009 VL 91 IS 4 BP 1381 EP 1384 DI 10.1016/j.fertnstert.2008.04.034 PG 4 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 432KT UT WOS:000265132600026 PM 18675970 ER PT J AU Jaeger, SR Cardello, AV AF Jaeger, Sara R. Cardello, Armand V. TI Direct and indirect hedonic scaling methods: A comparison of the labeled affective magnitude (LAM) scale and best-worst scaling SO FOOD QUALITY AND PREFERENCE LA English DT Article DE Research methodology; Choice of scaling method; Acceptance testing; Preference testing; Fruit juice; Need for cognition (NFC) ID LONG-TERM ACCEPTABILITY; FOOD ACCEPTABILITY; PREFERENCE; CATEGORY; TASTE; PLEASANTNESS; SWEETNESS; COGNITION; NEED; INFORMATION AB Affective or hedonic measurement is a cornerstone of sensory science, because it provides critical information about individuals' likes and dislikes for different products. Therefore, it is not surprising that debate about hedonic scaling is ongoing and that new methodology for hedonic scaling emerges regularly. The present research adds to this body of knowledge by comparing best-worst (BW) scaling, a choice-based methodology, with a direct scaling method, the labeled affective magnitude (LAM) scale. We begin with a literature review of direct and indirect scaling methods and then present two empirical studies that compare best-worst and LAM scaling. The key finding is that neither scaling method is superior to the other. However, what tentatively emerges is that choice of scaling method needs to be made in the context of the nature and complexity of the study to be conducted, the nature of the respondents, and the nature of the test samples themselves. With numerous criteria influencing the choice of hedonic scaling methodology, we advocate that researchers be explicit about the criteria that underlie their empirical work. (c) 2008 Elsevier Ltd. All rights reserved C1 [Jaeger, Sara R.] Hort & Food Res Inst New Zealand Ltd, Auckland, New Zealand. [Cardello, Armand V.] USA, Natick Soldier RD&E Ctr, Natick, MA 01760 USA. RP Jaeger, SR (reprint author), Hort & Food Res Inst New Zealand Ltd, Private Bag 92169, Auckland, New Zealand. EM sjaeger@hortresearch.co.nz RI Jaeger, Sara/R-2648-2016; OI Jaeger, Sara/0000-0002-4960-5233 NR 60 TC 24 Z9 24 U1 0 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD APR PY 2009 VL 20 IS 3 BP 249 EP 258 DI 10.1016/j.foodqual.2008.10.005 PG 10 WC Food Science & Technology SC Food Science & Technology GA 406QG UT WOS:000263309400010 ER PT J AU Wang, CB Widom, J Petronijevic, F Burnett, JC Nuss, JE Bavari, S Gussio, R Wipf, P AF Wang, Chenbo Widom, Julia Petronijevic, Filip Burnett, James C. Nuss, Jonathan E. Bavari, Sina Gussio, Rick Wipf, Peter TI SYNTHESIS AND BIOLOGICAL EVALUATION OF INHIBITORS OF BOTULINUM NEUROTOXIN METALLOPROTEASE SO HETEROCYCLES LA English DT Article DE NSC 240898; BoNT Serotype A Metalloprotease; Sonogashira Coupling; Gold-Catalyzed Indole Formation; Diaryl Ether ID SMALL-MOLECULE INHIBITORS; LIGHT-CHAIN; SEROTYPE-A; TOXIN; DERIVATIVES; MANAGEMENT; ARYL AB Based on the lead therapeutic agent NSC 240898, a new series of heterocyclic inhibitors of the BoNT serotype A metalloprotease has been generated. Highlights of the synthetic sequences include Sonogashira couplings of polysubstituted building blocks and gold-catalyzed indole formations. Preliminary structure-activity relationship studies afford detailed insights into the steric and electrostatic properties of the pharmacophore of this molecular scaffold. C1 [Wang, Chenbo; Widom, Julia; Petronijevic, Filip; Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. [Burnett, James C.] NCI, Target Struct Based Drug Discovery Grp, SAIC Frederick Inc, Frederick, MD 21702 USA. [Nuss, Jonathan E.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Gussio, Rick] NCI, Informat Technol Branch, Dev Therapeut Program, Frederick, MD 21702 USA. RP Wang, CB (reprint author), Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. FU National Cancer Institute; National Institutes of Health [N01-CO-12400]; Department of Defense [W81XWH-06-02-0027] FX This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported [in part] by the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute. This research was also funded from the Department of Defense, grant W81XWH-06-02-0027. The authors thank Ms. Jennie Kravchenko for the preparation of the tetrazole analogue of NSC 240898.26 NR 26 TC 15 Z9 15 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0385-5414 J9 HETEROCYCLES JI Heterocycles PD APR 1 PY 2009 VL 79 BP 487 EP 520 DI 10.3987/COM-08-S(D)8 PG 34 WC Chemistry, Organic SC Chemistry GA 452TN UT WOS:000266564200042 ER PT J AU Bojang, K Milligan, P Pinder, M Doherty, T Leach, A Ofori-Anyinam, O Lievens, M Kester, K Schaecher, K Ballou, WR Cohen, J AF Bojang, Kalifa Milligan, Paul Pinder, Margaret Doherty, Tom Leach, Amanda Ofori-Anyinam, Opokua Lievens, Marc Kester, Kent Schaecher, Kurt Ballou, W. Ripley Cohen, Joe TI Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS,S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia SO HUMAN VACCINES LA English DT Article DE malaria vaccine; RTS,S; five-year follow-up; long term persistence of anti-HBs; AS02 adjuvant system ID PLASMODIUM-FALCIPARUM INFECTION; RANDOMIZED CONTROLLED-TRIAL; HEPATITIS-B-VACCINE; PROTECTION; EFFICACY; CHILDREN; DISEASE AB RTS,S is a pre-erythrocytic malaria vaccine candidate antigen based on the circumsporozoite surface protein of Plasmodium falciparum fused to HBsAg, incorporating a novel Adjuvant System (AS02). The first field efficacy of RTS,S/AS02 against infection was demonstrated in a trial initiated in The Gambia in 1998. This paper presents the five-year safety and immunogenicity follow up of the 306 men who were enrolled in the original trial. In the primary study men aged 18 to 45 years were randomized to receive either RTS, S/AS02 or rabies vaccine at 0, 1, 5 months followed by a booster dose at month 19. The subjects were observed for long term safety and immunogenicity continuously until month 58. Of the 153 subjects in each group at enrollment, 80 (52%) subjects in the RTS,S/AS02 group and 83 (54%) subjects in the rabies group returned for the final long-term follow-up visit at month 58. The main reason for non-attendance at month 58 was migration (76% of all drop-outs). Nine subjects in the RTS, S/AS02 group and seven in the rabies group experienced serious adverse events (SAEs) over the 58 month surveillance period, of which seven had a fatal outcome (five RTS, S/AS02 and two rabies group). None of the SAEs with fatal outcome were attributed to the study vaccine. Anti-CS antibody persistence compared to control was observed for five years, although titres had waned from post-booster levels; similar responses in anti-HBs antibody persistence were observed in initially HBsAg seronegative subjects. This study provides the first indication of the long-term safety and persistence of anti-CS and anti-HBs antibodies of the RTS, S vaccine candidate in combination with the novel AS02 Adjuvant System. C1 [Bojang, Kalifa; Pinder, Margaret] MRC Labs, Banjul, Gambia. [Milligan, Paul; Doherty, Tom] London Sch Hyg & Trop Med, London WC1, England. [Leach, Amanda; Ofori-Anyinam, Opokua; Lievens, Marc; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Kester, Kent; Schaecher, Kurt] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Ballou, W. Ripley] Bill & Melinda Gates Fdn, Seattle, WA USA. RP Bojang, K (reprint author), MRC Labs, Atlantic Blvd, Banjul, Gambia. EM kbojang@mrc.gm RI Kester, Kent/A-2114-2011; Milligan, Paul/D-8985-2017 OI Kester, Kent/0000-0002-5056-0802; Milligan, Paul/0000-0003-3430-3395 FU Medical Research Council [G0700837] NR 13 TC 21 Z9 23 U1 0 U2 1 PU LANDES BIOSCIENCE PI AUSTIN PA 1002 WEST AVENUE, 2ND FLOOR, AUSTIN, TX 78701 USA SN 1554-8619 J9 HUM VACCINES JI Hum. Vaccines PD APR PY 2009 VL 5 IS 4 BP 242 EP 247 PG 6 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 453BS UT WOS:000266585600008 PM 19276646 ER PT J AU Kaplan, LM Burks, SD Blum, RS Moore, RK Nguyen, Q AF Kaplan, Lance M. Burks, Stephen D. Blum, Rick S. Moore, Richard K. Nguyen, Quang TI Analysis of Image Quality for Image Fusion via Monotonic Correlation SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING LA English DT Article DE Image fusion; image quality; monotonic correlation; isotonic regression ID ISOTONIC REGRESSION; PERFORMANCE; CLUTTER; INFORMATION; ALGORITHMS; SCHEMES; MODELS AB This paper introduces a nonlinear correlation coefficient that exploits isotonic (or monotonic) regression. We refer to this correlation coefficient as the monotonic correlation (MC). This paper demonstrates how the MC scores the consistency between possible image quality (IQ) features and actual human performance, which is measured by a perception study. This paper also shows the relationship between the MC and the generalized likelihood ratio (GLR) test for the H, hypothesis that the IQ features are monotonically related to intrinsic human performance versus the null hypothesis that the relationship is arbitrary. Finally, the paper introduces a normalized GLR in order to assess the statistical significance of a high MC value. Using actual results from human perception experiments and the corresponding proposed IQ feature values for the imagery, the paper demonstrates how MC can identify worthy features that could be overlooked by traditional correlation values. The focus of the experiments center around the evaluation of IQ measures for image fusion applications. C1 [Kaplan, Lance M.] USA, Res Lab, Adelphi, MD 20783 USA. [Burks, Stephen D.; Nguyen, Quang] Night Vis Elect Syst Directorate, Ft Belvoir, VA 22060 USA. [Blum, Rick S.] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. [Moore, Richard K.] Univ Memphis, Memphis, TN 38152 USA. RP Kaplan, LM (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM lance.m.kaplan@us.army.mil; stephen.burks1@us.army.mil; rblum@ece.lehigh.edu; rkmoore@memphis.edu; hongquang.nguyen@us.army.mil NR 46 TC 7 Z9 7 U1 1 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1932-4553 J9 IEEE J-STSP JI IEEE J. Sel. Top. Signal Process. PD APR PY 2009 VL 3 IS 2 BP 222 EP 235 DI 10.1109/JSTSP.2009.2014500 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA 439TH UT WOS:000265649400005 ER PT J AU Li, JL Liu, XQ Swami, A AF Li, Jingli Liu, Xiangqian Swami, Ananthram TI Collision Analysis for Coexistence of Multiple Bluetooth Piconets and WLAN with Dual Channel Transmission SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Co-channel interference; Bluetooth; WLAN; frequency diversity ID INTERFERENCE AB Co-channel interference (CCI) has become an important problem with the increasing deployment of wireless networks in the unlicensed frequency band. The existing Bluetooth scheme avoids collisions by modifying its hop sequences in the presence of WLAN. We propose a frequency diversity technique, namely dual channel transmission (DCT), which reduces packet error rate (PER) due to CCI when multiple Bluetooth piconets; coexist with or without WLAN interference. The idea of DCT is to transmit the same packet on two distinct frequency hopped channels simultaneously and the power used in each channel is half of what would be used in single channel transmission (SCT). Since a packet is successfully received if at least one channel survives, the PER is reduced even when multiple piconets coexist. Further, the two channels of DCT are separated by at least 22 MHz to ensure robustness to WLAN interference. Theoretic analysis and numerical simulations on key metrics - PER, throughput, and transmission time are presented to validate the proposed approach and quantify its advantages. Comparisons to other coexistence mechanisms also demonstrate the effectiveness of DCT. C1 [Li, Jingli] TopWorx Inc, Louisville, KY 40213 USA. [Liu, Xiangqian] Univ Louisville, Dept Elect & Comp Engn, Louisville, KY 40292 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Li, JL (reprint author), TopWorx Inc, Louisville, KY 40213 USA. EM jingli_li@hotmail.com; x.liu@louisville.edu; a.swami@ieee.org FU U.S. Army Research Office [W91 1NF-06-1-0415] FX This material is based oil work supported by the U.S. Army Research Office under grant number W91 1NF-06-1-0415. Parts of this work were presented at ICC 2007 and WCNC 2007. NR 19 TC 5 Z9 8 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD APR PY 2009 VL 57 IS 4 BP 1129 EP 1139 DI 10.1109/TCOMM.2009.04.070103 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 435WJ UT WOS:000265373700034 ER PT J AU Wang, W Adah, T Emge, D AF Wang, Wei Adah, Tuelay Emge, Darren TI Subspace Partitioning for Target Detection and Identification SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Classification; Raman spectroscopy; subspace partitioning; target detection and identification ID MODEL; GRAPH AB Detection of a given target or set of targets from observed data is a problem countered in many applications. Regardless of the algorithm selected, detection performance can be severely degraded when the subspace defined by the target data set is singular or ill conditioned. High correlations between target components and their linear combinations lead to false positives and misidentifications, especially for subspace-based detectors. In this paper, we propose a subspace partitioning scheme that allows for detection to be performed in a number of better conditioned subspaces instead of the original subspace. The proposed technique is applied to Raman spectroscopic data analysis. Through both simulation and experimental results, we demonstrate the improvement in the overall detection performance when using the proposed subspace partitioning scheme in conjunction with several subspace detection methods that are commonly used in practice. C1 [Wang, Wei; Adah, Tuelay] Univ Maryland Baltimore Cty, Dept Comp Sci & Elect Engn, Baltimore, MD 21228 USA. [Emge, Darren] USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Wang, W (reprint author), Univ Maryland Baltimore Cty, Dept Comp Sci & Elect Engn, Baltimore, MD 21228 USA. EM wangw1@umbc.edu; adali@umbc.edu; darren.emge@us.army.mil NR 17 TC 4 Z9 5 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD APR PY 2009 VL 57 IS 4 BP 1250 EP 1259 DI 10.1109/TSP.2009.2012559 PG 10 WC Engineering, Electrical & Electronic SC Engineering GA 419VI UT WOS:000264247400002 ER PT J AU Ma, XL Zhang, W Swami, A AF Ma, Xiaoli Zhang, Wei Swami, Ananthram TI Lattice-Reduction Aided Equalization for OFDM Systems SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article; Proceedings Paper CT IEEE Military Communications Conference (MILCOM 2005) CY OCT, 2005 CL Atlantic City, NJ SP IEEE DE OFDM; diversity; linear equalizers; lattice reduction ID MAXIMUM MULTIPATH DIVERSITY; LINEAR EQUALIZATION; PERFORMANCE; CHANNELS AB Orthogonal Frequency Division Multiplexing (OFDM) is an effective technique to deal with frequency-selective channels since it facilitates low complexity equalization and decoding. Many existing OFDM designs successfully exploit the multipath diversity offered by frequency-selective channels. However, most of them require maximum likelihood (ML) or near-ML detection at the receiver, which is of high complexity. On the other hand, empirical results have shown that linear detectors have low complexity but offer inferior performance. In this paper, we analytically quantify the diversity orders of linear equalizers for linear precoded OFDM systems, and prove that they are unable to collect full diversity. To improve the performance of linear equalizers, we further propose to use a lattice reduction (LR) technique to help collect diversity. The LR-aided linear equalizers are shown to achieve maximum diversity order (i.e., the one collected by the ML detector), but with low complexity that is comparable to that of conventional linear equalizers. The theoretical findings are corroborated by simulation results. C1 [Ma, Xiaoli; Zhang, Wei] Georgia Inst Technol, Sch Elect & Comp Engr, Atlanta, GA 30332 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Ma, XL (reprint author), Georgia Inst Technol, Sch Elect & Comp Engr, Atlanta, GA 30332 USA. EM xiaoli@ece.gatech.edu; zhangw1@ece.gatech.edu; a.swami@ieee.org NR 17 TC 9 Z9 9 U1 2 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1276 EI 1558-2248 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD APR PY 2009 VL 8 IS 4 BP 1608 EP 1613 DI 10.1109/T-WC.2009.070987 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 435WD UT WOS:000265373100005 ER PT J AU Cheng, S Valenti, MC Torrieri, D AF Cheng, Shi Valenti, Matthew C. Torrieri, Don TI Coherent Continuous-Phase Frequency-Shift Keying: Parameter Optimization and Code Design SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE Continuous-phase modulation; CPM; Capacity; Channel coding ID DENSITY GENERATOR MATRIX; REPEAT-ACCUMULATE CODES; PARITY-CHECK CODES; INFORMATION RATES; LINEAR CODES; MODULATION; PERFORMANCE; CPM AB The symmetric information rate of a modulation-constrained transmission system is the information-theoretic limit on performance under the assumption that the inputs are independent and uniformly distributed. The symmetric information rate for continuous-phase frequency-shift keying (CPFSK) over an AWGN channel may be estimated by considering the system to be a finite-state Markov channel and executing a BCJR-like algorithm. In this paper, the estimated symmetric information rate is used along with the exact expression for the 99% power bandwidth to determine the information-theoretic tradeoff between energy and spectral efficiency for CPFSK modulation. Using this tradeoff, the code rate and modulation index are jointly optimized for a particular spectral efficiency and alphabet size. Codes are then designed for the optimized system. The codes are comprised of variable nodes (which represent irregular repetition codes), check nodes (which represent single parity-check codes), and an interleaver connecting the variable and check nodes. The degree distributions of the code are optimized from the system's EXIT chart by using linear programming. Additional details of the code design, including labeling and interleaver design, are also discussed. Simulation results show that the optimized coded systems achieve bit error rates within 0.4 dB of the information-theoretic limits at BER = 10(-5). C1 [Cheng, Shi] ArrayComm LLC, San Jose, CA USA. [Valenti, Matthew C.] W Virginia Univ, Lane Dept Comp Sci & Elect Engn, Morgantown, WV 26506 USA. [Torrieri, Don] USA, Res Lab, Adelphi, MD USA. RP Cheng, S (reprint author), ArrayComm LLC, San Jose, CA USA. EM shi.cheng@gmail.com; mvalenti@wvu.edu; dtorr@arl.army.mil OI Valenti, Matthew/0000-0001-6089-0509 NR 31 TC 10 Z9 10 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD APR PY 2009 VL 8 IS 4 BP 1792 EP 1802 DI 10.1109/TWC.2009.071311 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 435WD UT WOS:000265373100030 ER PT J AU Shanks, J Burtnick, MN Brett, PJ Waag, DM Spurgers, KB Ribot, WJ Schell, MA Panchal, RG Gherardini, FC Wilkinson, KD DeShazer, D AF Shanks, John Burtnick, Mary N. Brett, Paul J. Waag, David M. Spurgers, Kevin B. Ribot, Wilson J. Schell, Mark A. Panchal, Rekha G. Gherardini, Frank C. Wilkinson, Keith D. DeShazer, David TI Burkholderia mallei tssM Encodes a Putative Deubiquitinase That Is Secreted and Expressed inside Infected RAW 264.7 Murine Macrophages SO INFECTION AND IMMUNITY LA English DT Article ID UBIQUITIN-LIKE PROTEINS; NF-KAPPA-B; VIRULENCE DETERMINANT; VI SECRETION; GLANDERS; PSEUDOMALLEI; SYSTEM; ENZYMES; BACTERIA; MUTANTS AB Burkholderia mallei, a category B biothreat agent, is a facultative intracellular pathogen that causes the zoonotic disease glanders. The B. mallei VirAG two-component regulatory system activates the transcription of similar to 60 genes, including a large virulence gene cluster encoding a type VI secretion system (T6SS). The B. mallei tssM gene encodes a putative ubiquitin-specific protease that is physically linked to, and transcriptionally coregulated with, the T6SS gene cluster. Mass spectrometry and immunoblot analysis demonstrated that TssM was secreted in a virAG-dependent manner in vitro. Surprisingly, the T6SS was found to be dispensable for the secretion of TssM. The C-terminal half of TssM, which contains Cys and His box motifs conserved in eukaryotic deubiquitinases, was purified and biochemically characterized. Recombinant TssM hydrolyzed multiple ubiquitinated substrates and the cysteine at position 102 was critical for enzymatic activity. The tssM gene was expressed within 1 h after uptake of B. mallei into RAW 264.7 murine macrophages, suggesting that the TssM deubiquitinase is produced in this intracellular niche. Although the physiological substrate(s) is currently unknown, the TssM deubiquitinase may provide B. mallei a selective advantage in the intracellular environment during infection. C1 [Waag, David M.; Spurgers, Kevin B.; Ribot, Wilson J.; Panchal, Rekha G.; DeShazer, David] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. [Shanks, John; Wilkinson, Keith D.] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA. [Burtnick, Mary N.; Brett, Paul J.; Gherardini, Frank C.] NIAID, Lab Zoonot Pathogens, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA. [Schell, Mark A.] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA. RP DeShazer, D (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM david.deshazer@amedd.army.mil FU Medical Biological Defense Research Program; U. S. Army Medical Research and Materiel Command [06-4-2P-004]; NIAID Interagency Agreement [Y1-AI-5004-01]; National Institutes of Health [GM030308, GM066355, 1-R21-I069081] FX We are grateful to Vinod Nair for assistance with confocal microscopy and to Anthony Bassett for assistance with animal experiments.; The research described here was sponsored by the Medical Biological Defense Research Program, U. S. Army Medical Research and Materiel Command, Project 06-4-2P-004 (to D. D.), NIAID Interagency Agreement Y1-AI-5004-01 (to D. D.), and National Institutes of Health grants GM030308 and GM066355 (to K. D. W.) and 1-R21-I069081 (to M. A. S.).; The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U. S. Army in accordance with AR 70-31. NR 65 TC 28 Z9 30 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2009 VL 77 IS 4 BP 1636 EP 1648 DI 10.1128/IAI.01339-08 PG 13 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 419AM UT WOS:000264191500040 PM 19168747 ER PT J AU Becker, SJ Hospenthal, DR AF Becker, Sara J. Hospenthal, Duane R. TI Update on Therapy for Histoplasmosis SO INFECTIONS IN MEDICINE LA English DT Article DE Histoplasmosis; Amphotericin B; Itraconazole ID LIPOSOMAL AMPHOTERICIN-B; PULMONARY CHALLENGE; ITRACONAZOLE; FLUCONAZOLE; EFFICACY C1 [Hospenthal, Duane R.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. NR 16 TC 1 Z9 1 U1 0 U2 1 PU SCP COMMUNICATIONS INC PI NEW YORK PA 134 W 29TH ST, NEW YORK, NY 10001-5304 USA SN 0749-6524 J9 INFECT MED JI Infect. Med. PD APR PY 2009 VL 26 IS 4 BP 121 EP 124 PG 4 WC Infectious Diseases SC Infectious Diseases GA 430KN UT WOS:000264988100004 ER PT J AU Karakaya, P Christodoulatos, C Koutsospyros, A Balas, W Nicolich, S Sidhoum, M AF Karakaya, Pelin Christodoulatos, Christos Koutsospyros, Agamemnon Balas, Wendy Nicolich, Steve Sidhoum, Mohammed TI Biodegradation of the High Explosive Hexanitrohexaazaisowurtzitane (CL-20) SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE Hexanitrohexaazaisowurtzitane; CL-20; biodegradation; activated sludge; Phanerochaete chrysosporium; logistic growth model; mineralization ID WHITE-ROT FUNGUS; PHANEROCHAETE-CHRYSOSPORIUM; WASTE-WATER; ALKALINE-HYDROLYSIS; LIGNIN PEROXIDASE; DEGRADATION; BIOTRANSFORMATION; RDX; HMX; SUBSTANCE AB The aerobic biodegradability of the high explosive CL-20 by activated sludge and the white rot fungus Phanerochaete chrysosporium has been investigated. Although activated sludge is not effective in degrading CL-20 directly, it can mineralize the alkaline hydrolysis products. Phanerochaete chrysosporium degrades CL-20 in the presence of supplementary carbon and nitrogen sources. Biodegradation studies were conducted using various nutrient media under diverse conditions. Variables included the CL-20 concentration; levels of carbon (as glycerol) and ammonium sulfate and yeast extract as sources of nitrogen. Cultures that received CL-20 at the time of inoculation transformed CL-20 completely under all nutrient conditions studied. When CL-20 was added to pre-grown cultures, degradation was limited. The extent of mineralization was monitored by the (14)CO(2) time evolution; up to 51% mineralization was achieved when the fungus was incubated with [(14)C]-CL-20. The kinetics of CL-20 biodegradation by Phanerochaete chrysosporium follows the logistic kinetic growth model. C1 [Christodoulatos, Christos; Sidhoum, Mohammed] Stevens Inst Technol, Hoboken, NJ 07030 USA. [Karakaya, Pelin] Langan Engn & Environm Serv, Elmwood Pk, NJ 07407 USA. [Koutsospyros, Agamemnon] Univ New Haven, Dept Civil Mech & Environm Engn, West Haven, CT 06516 USA. [Balas, Wendy; Nicolich, Steve] USA, TACOM ARDEC, Energet & Warheads Div, Picatinny Arsenal, NJ 07806 USA. [Sidhoum, Mohammed] PMK Grp Inc, ERCP Div, Farmingdale, NJ 07727 USA. RP Sidhoum, M (reprint author), Stevens Inst Technol, Hoboken, NJ 07030 USA. EM msidhoum@stevens.ed FU DOD US ARMY TACOM/ARDEC [DAAE30-00D-1011 7] FX This research was supported by the DOD US ARMY TACOM/ARDEC Contract No. DAAE30-00D-1011 #7. NR 35 TC 2 Z9 2 U1 4 U2 10 PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI PI BASEL PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD APR PY 2009 VL 6 IS 4 BP 1371 EP 1392 DI 10.3390/ijerph6041371 PG 22 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 451BK UT WOS:000266445500006 PM 19440524 ER PT J AU Jin, ZT Zhang, HQ Li, SQ Kim, M Dunne, CP Yang, T Wright, AO Venter-Gains, J AF Jin, Z. T. Zhang, H. Q. Li, S. Q. Kim, M. Dunne, C. P. Yang, T. Wright, A. O. Venter-Gains, J. TI Quality of applesauces processed by pulsed electric fields and HTST pasteurisation SO INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY LA English DT Article DE Applesauce; aseptic packaging; HTST; PEF; sensory quality; shelf stability ID ORANGE JUICE; INACTIVATION; PRODUCTS; SYSTEM; FOODS AB A pilot plant scale continuous flow pulsed electric field (PEF) and high temperature short time (HTST) processing system was integrated with an aseptic packaging machine. Fuji applesauce and blueberry applesauce were processed with PEF followed by HTST pasteurisation (PEF + HTST). PEF + HTST processed Fuji applesauce from fresh Fuji apples demonstrated high and stable sensory scores during 9 months storage at 27 degrees C, and had comparative sensory quality with Meal Read-to-Eat (MRE) and commercial applesauce products stored at 4 degrees C. PEF + HTST processed blueberry applesauce from pre-pasteurised materials had lower sensory scores than PEF + HTST processed Fuji applesauce and was significantly less stable during the storage at 27 degrees C. PEF + HTST processed applesauces had aerobic count and mould and yeast count of < 10 cfu mL(-1) during storage. Electrical conductivity, pH and degrees Brix, were not significantly changed throughout storage time (P > 0.05). C1 [Jin, Z. T.; Zhang, H. Q.] USDA ARS NAA ERRC, Wyndmoor, PA 19038 USA. [Li, S. Q.] Michael Foods Inc, Gaylord, MN 55334 USA. [Kim, M.] Cargill Dressings Sauces & Oils DSONA, Sidney, OH 45365 USA. [Dunne, C. P.; Yang, T.; Wright, A. O.; Venter-Gains, J.] USA, Natick Soldier Syst Ctr, Natick, MA 01760 USA. RP Jin, ZT (reprint author), USDA ARS NAA ERRC, 600 E Mermaid Lane, Wyndmoor, PA 19038 USA. EM tony.jin@ars.usda.gov OI Jin, Tony/0000-0003-0504-5817 FU US Army Natick Soldier System Center FX We are grateful to US Army Natick Soldier System Center for funding the project, Ameriqual Inc. of Evansville, IN, USA for providing MRE applesauce products and Maine Wild Blueberry Company for providing blueberry purees. The authors wish to thank Mr Rod Cardwell for operating the high voltage pulse generator and Ms Alissia Lodi for operating the aseptic packaging machine. NR 16 TC 6 Z9 10 U1 2 U2 8 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0950-5423 J9 INT J FOOD SCI TECH JI Int. J. Food Sci. Technol. PD APR PY 2009 VL 44 IS 4 BP 829 EP 839 DI 10.1111/j.1365-2621.2009.01912.x PG 11 WC Food Science & Technology SC Food Science & Technology GA 418YJ UT WOS:000264185700023 ER PT J AU Kanel, GI Zaretsky, EB Rajendran, AM Razorenov, SV Savinykh, AS Paris, V AF Kanel, G. I. Zaretsky, E. B. Rajendran, A. M. Razorenov, S. V. Savinykh, A. S. Paris, V. TI Search for conditions of compressive fracture of hard brittle ceramics at impact loading SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article DE Dynamic fracture; Shock waves; Ceramic materials; Plate impact ID SHOCK-WAVE; FAILURE; TRANSITION; SAPPHIRE; BEHAVIOR; SOLIDS; PHASE AB In this paper we discuss three different experimental configurations to diagnosing the modes of inelastic deformation and to evaluating the failure thresholds at shock compression of hard brittle solids. One of the manifestations of brittle material response is the failure wave phenomenon, which has been previously observed in shock-compressed glasses. However, based on the measurements from our "theory critical" experiments, both alumina and boron carbide did not exhibit this phenomenon. In experiments with free and pre-stressed ceramics, while the Hugoniot elastic limit (HEL) in high-density B(4)C ceramic was found to be very sensitive to the transverse stress, it was found relatively less sensitive in Al(2)O(3), implying brittle response of the boron carbide and ductile behavior of alumina. To further investigate the effects of stress states on the shock response of brittle materials, a "divergent flow or spherical shock wave" based plate impact experimental technique was employed to vary the ratio of longitudinal and transversal stresses and to probe conditions for compressive fracture thresholds. Two different experimental approaches were considered to generate both longitudinal and shear waves in the target through the impact of convex flyer plates. In the ceramic target plates, the shear wave separates a region of highly divergent flow behind the decaying spherical longitudinal shock wave and a region of low-divergent flow. Experiments with divergent shock loading of alumina and boron carbide ceramic plates coupled with computer simulations demonstrated the validity of these experimental approaches to develop a better understanding of fracture phenomena. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Kanel, G. I.] IVTAN, Joint Inst High Temp, Moscow 125412, Russia. [Zaretsky, E. B.; Paris, V.] Ben Gurion Univ Negev, Dept Mech Engn, IL-84105 Beer Sheva, Israel. [Rajendran, A. M.] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Razorenov, S. V.; Savinykh, A. S.] Inst Problems Chem Phys, Chernogolovka 142432, Russia. RP Kanel, GI (reprint author), IVTAN, Joint Inst High Temp, Izhorskaya 13-19, Moscow 125412, Russia. EM kanel@ficp.ac.ru RI Rajendran, Arunachalam/A-1615-2010; Kanel, Gennady/K-1657-2013; Razorenov, Sergei/O-6450-2014 FU European Research Office in London; Russian Academy of Sciences FX The work was partially supported by the European Research Office in London through a US Army Research Office grant and by the Program of Basic Research of the Russian Academy of Sciences "Damage accumulation, fracture, wear-out and structural transformations of materials under intense mechanical, thermal and radioactive attacks". NR 28 TC 23 Z9 25 U1 3 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0749-6419 J9 INT J PLASTICITY JI Int. J. Plast. PD APR PY 2009 VL 25 IS 4 BP 649 EP 670 DI 10.1016/j.ijplas.2008.12.004 PG 22 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA 426RW UT WOS:000264726400006 ER PT J AU Edelstein, AS Burnette, JE Fischer, GA Olver, K Egelhoff, W Nowak, E Cheng, SF AF Edelstein, A. S. Burnette, J. E. Fischer, G. A. Olver, K. Egelhoff, Wm., Jr. Nowak, E. Cheng, Shu-Fan TI Validation of the microelectromechanical system flux concentrator concept for minimizing the effect of 1/f noise SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 53rd Annual Conference on Magnetism and Magnetic Materials CY NOV 11-14, 2008 CL Austin, TX SP Phys Conf Inc, IEEE, Magnet Soc ID ROOM-TEMPERATURE; MAGNETORESISTANCE; MAGNETOMETER AB With the microelectromechanical system (MEMS) flux concentrator, we have been able to increase the operating frequency of small magnetic sensors above the region where 1/f noise dominates. The device accomplished this by modulating the field via the oscillatory motion of flux concentrators on MEMS flaps. Electrostatic comb drives were used to drive the MEMS flaps. We have demonstrated an increase in the signal to noise ratio at 1 Hz, that the power signal correctly depends on V(4) where V is the amplitude of the voltage energizing the comb drives, and that the signal increases dramatically with vacuum packaging. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3076497] C1 [Edelstein, A. S.; Burnette, J. E.; Fischer, G. A.; Olver, K.] USA, Res Lab, Adelphi, MD 20783 USA. [Egelhoff, Wm., Jr.] NIST, Gaithersburg, MD 20899 USA. [Nowak, E.] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA. [Cheng, Shu-Fan] USN, Res Lab, Washington, DC 20375 USA. RP Edelstein, AS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM edelstein@arl.army.mil NR 14 TC 18 Z9 19 U1 3 U2 14 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 1 PY 2009 VL 105 IS 7 AR 07E720 DI 10.1063/1.3076497 PG 3 WC Physics, Applied SC Physics GA 453SX UT WOS:000266633500722 ER PT J AU Ellis, MW Griffith, ME Jorgensen, JH Hospenthal, DR Mende, K Patterson, JE AF Ellis, Michael W. Griffith, Matthew E. Jorgensen, James H. Hospenthal, Duane R. Mende, Katrin Patterson, Jan E. TI Presence and Molecular Epidemiology of Virulence Factors in Methicillin-Resistant Staphylococcus aureus Strains Colonizing and Infecting Soldiers SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID PANTON-VALENTINE LEUKOCIDIN; FIELD GEL-ELECTROPHORESIS; CATABOLIC MOBILE ELEMENT; NECROTIZING PNEUMONIA; NASAL CARRIAGE; UNITED-STATES; COLONIZATION; EMERGENCE; GENES; CLONE AB Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as an important cause of skin and soft-tissue infections (SSTI). The understanding of the molecular epidemiology and virulence of MRSA continues to expand. From January 2005 to December 2005, we screened soldiers for MRSA nasal colonization, administered a demographic questionnaire, and monitored them prospectively for SSTI. All MRSA isolates underwent molecular analysis, which included pulsed-filed gel electrophoresis (PFGE) and PCR for Panton-Valentine leukocidin (PVL), the arginine catabolic mobile element (ACME), and the staphylococcal cassette chromosome mec (SCCmec). Of the 3,447 soldiers screened, 134 (3.9%) had MRSA colonization. Of the 3,066 (89%) who completed the study, 39 developed culture-confirmed MRSA abscesses. Clone USA300 represented 53% of colonizing isolates but was responsible for 97% of the abscesses (P < 0.001). Unlike colonizing isolates, isolates positive for USA300, PVL, ACME, and type IV SCCmec were significantly associated with MRSA abscess isolates. As determined by multivariate analysis, risk factors for MRSA colonization were a history of SSTI and a history of hospitalization. Although various MRSA strains may colonize soldiers, USA300 is the most virulent when evaluated prospectively, and PVL, ACME, and type IV SCCmec are associated with these abscesses. C1 [Ellis, Michael W.; Griffith, Matthew E.; Hospenthal, Duane R.] Brooke Army Med Ctr, Dept Med Infect Dis, San Antonio, TX USA. [Jorgensen, James H.; Patterson, Jan E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Patterson, Jan E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med Infect Dis, San Antonio, TX 78229 USA. [Ellis, Michael W.] Uniformed Serv Univ Hlth Sci, Dept Med Infect Dis, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Patterson, Jan E.] S Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Ellis, MW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med Infect Dis, Infect Dis Clin Res Program, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM michael.w.ellis@us.army.mil RI Valle, Ruben/A-7512-2013 NR 46 TC 25 Z9 26 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 2009 VL 47 IS 4 BP 940 EP 945 DI 10.1128/JCM.02352-08 PG 6 WC Microbiology SC Microbiology GA 427RS UT WOS:000264797000011 PM 19213694 ER PT J AU Sousa, ES Sadler, BM Hossain, E Jafar, SA AF Sousa, Elvino S. Sadler, Brian M. Hossain, Ekram Jafar, Syed Ali TI Cognitive Radio: A Path in the Evolution of Public Wireless Networks SO JOURNAL OF COMMUNICATIONS AND NETWORKS LA English DT Editorial Material C1 [Sousa, Elvino S.] Univ Toronto, Dept Elect & Comp Engn, Toronto, ON M5S 1A1, Canada. [Sadler, Brian M.] USA, Res Lab, Adelphi, MD USA. [Hossain, Ekram] Univ Manitoba, Dept Elect & Comp Engn, Winnipeg, MB R3T 2N2, Canada. [Jafar, Syed Ali] Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA USA. RP Sousa, ES (reprint author), Univ Toronto, Dept Elect & Comp Engn, Toronto, ON M5S 1A1, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU KOREAN INST COMMUNICATIONS SCIENCES (K I C S) PI SEOUL PA HYUNDAI KIRIM OFFICETEL 1504-6 SEOCHODONG 1330-18, SEOCHOKU, SEOUL 137-070, SOUTH KOREA SN 1229-2370 J9 J COMMUN NETW-S KOR JI J. Commun. Netw. PD APR PY 2009 VL 11 IS 2 BP 99 EP 103 PG 5 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA 455EP UT WOS:000266741100001 ER PT J AU Wong, D Nguyen, L Gaunaurd, GC Sullivan, A AF Wong, David Nguyen, Lam Gaunaurd, Guillermo C. Sullivan, Anders TI Time-frequency analysis of synthetic aperture radar images of selected ordnance pieces SO JOURNAL OF ELECTRONIC IMAGING LA English DT Article ID DOMAIN AB We present a modification of the standard time-frequency (t-f) analysis for landmine detection. The modification is adapted to synthetic aperture radar (SAR) images that may or may not exhibit near-circular symmetry. Each prospective SAR image is here sliced along several directions to generate t-f plots along those chosen cuts, and the resulting 2-D plots are correlated in pairs to obtain a relevant metric, which is defined as their ratio. This metric has served to distinguish targets from clutter objects in the various cases examined here. The procedure was validated using a dataset obtained in a recent field test, and the results are shown. (C) 2009 SPIE and IS&T. [DOI: 10.1117/1.3134134] C1 [Wong, David; Nguyen, Lam; Gaunaurd, Guillermo C.; Sullivan, Anders] USA, Res Lab, Adelphi, MD 20783 USA. RP Wong, D (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM asullivan@arl.army.mil NR 12 TC 0 Z9 0 U1 0 U2 2 PU I S & T - SOC IMAGING SCIENCE TECHNOLOGY PI SPRINGFIELD PA 7003 KILWORTH LANE, SPRINGFIELD, VA 22151 USA SN 1017-9909 J9 J ELECTRON IMAGING JI J. Electron. Imaging PD APR-JUN PY 2009 VL 18 IS 2 AR 023011 DI 10.1117/1.3134134 PG 10 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA 477WU UT WOS:000268550500013 ER PT J AU George, S La Rochelle, J Omalley, P AF George, S. La Rochelle, J. Omalley, P. TI FACULTY EVALUATION OF MEDICAL STUDENT HISTORY AND PHYSICAL EXAM SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 32nd Annual Meeting of the Society-of-General-Internal-Medicine CY MAY 13-16, 2009 CL Miami, FL SP Soc Gen Internal Med C1 [George, S.; La Rochelle, J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Omalley, P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2009 VL 24 SU 1 BP 75 EP 75 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 435ZI UT WOS:000265382000203 ER PT J AU Cannarozzi, ML Wahi, MM Nixon, L Galloway, M Goldin, SB AF Cannarozzi, M. L. Wahi, M. M. Nixon, L. Galloway, M. Goldin, S. B. TI STUDENT PROFESSIONALISM DID NOT INCREASE WITH THE IMPLEMENTATION OF A NOVEL CURRICULUM PROMOTING AAMC PROFESSIONALISM DOMAINS IN THE INTEGRATED INPATIENT INTERNAL MEDICINE/PEDIATRICS JUNIOR CLERKSHIP SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 32nd Annual Meeting of the Society-of-General-Internal-Medicine CY MAY 13-16, 2009 CL Miami, FL SP Soc Gen Internal Med C1 [Cannarozzi, M. L.] Univ Cent Florida, Orlando, FL 32816 USA. [Wahi, M. M.] USA, Environm Med Res Inst, Boston, MA USA. [Nixon, L.; Galloway, M.; Goldin, S. B.] Univ S Florida, Tampa, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2009 VL 24 SU 1 BP 174 EP 174 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 435ZI UT WOS:000265382000464 ER PT J AU Sessums, LL O'Malley, PG AF Sessums, L. L. O'Malley, P. G. TI TEAMS-S: TRAINING AND EDUCATION ABOUT ALLIED MEDICAL STAFF USING SHADOWING SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 32nd Annual Meeting of the Society-of-General-Internal-Medicine CY MAY 13-16, 2009 CL Miami, FL SP Soc Gen Internal Med C1 [Sessums, L. L.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [O'Malley, P. G.] Uniformed Serv Univ Hlth Sci, Chevy Chase, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2009 VL 24 SU 1 BP 244 EP 244 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 435ZI UT WOS:000265382000643 ER PT J AU Jackson, JL George, S Hinchey, S AF Jackson, Jeffrey L. George, Susan Hinchey, Sherri TI Medically Unexplained Physical Symptoms SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Editorial Material ID PRIMARY-CARE; MULTISOMATOFORM DISORDER; FIBROMYALGIA; PATIENT; OUTCOMES; THERAPY C1 [George, Susan; Hinchey, Sherri] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Jackson, Jeffrey L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Jackson, JL (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM jejackson@usuhs.mil NR 17 TC 4 Z9 4 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD APR PY 2009 VL 24 IS 4 BP 540 EP 542 DI 10.1007/s11606-009-0932-x PG 3 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 423GJ UT WOS:000264484500017 PM 19255810 ER PT J AU Goldman, SB Brininger, TL Antczak, A AF Goldman, Sarah B. Brininger, Teresa L. Antczak, Amanda TI Clinical Relevance of Neuromuscular Findings and Abnormal Movement Patterns: A Comparison between Focal Hand Dystonia and Upper Extremity Entrapment Neuropathies SO JOURNAL OF HAND THERAPY LA English DT Article ID CARPAL-TUNNEL-SYNDROME; CRAMP-FASCICULATION SYNDROME; MULTIFOCAL MOTOR NEUROPATHY; RANDOMIZED CONTROLLED-TRIAL; WRITERS CRAMP; PERIPHERAL NEUROPATHY; CONDUCTION BLOCK; LASER THERAPY; BEHAVIORAL TREATMENT; ULNAR NEUROPATHY AB Narrative Review: Patients with focal hand dystonia and upper extremity entrapment neuropathies may present with similar symptoms and risk factors making it difficult to distinguish between the two diagnoses. Evaluating for the presence of neuromuscular findings and abnormal movement patterns can help assist the hand therapist in identifying the presence of focal hand dystonia or peripheral motor axon involvement in the absence of pronounced muscle atrophy. The purposes of this review article are twofold. First, to describe selected neuromuscular signs and symptoms characteristic of patients presenting with repetitive overuse syndromes of the upper limb leading to either a nerve entrapment syndrome or a focal hand dystonia. The selected topics will be limited to an overview of ectopic neuronal activity with an emphasis on fasciculations, muscle spasms/cramps, and sensation (including pain). Second, the article will conclude with a brief synopsis of focal hand dystonia and compression neuropathies, highlighting general assessment and treatment principles. J HAND THER. 2009;22:115-24. C1 [Goldman, Sarah B.; Antczak, Amanda] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Brininger, Teresa L.] Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Goldman, SB (reprint author), USA, Environm Med Res Inst, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM sarah.goldman@us.army.mil NR 80 TC 0 Z9 0 U1 0 U2 2 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 EI 1545-004X J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2009 VL 22 IS 2 SI SI BP 115 EP 123 DI 10.1016/j.jht.2008.12.004 PG 9 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 442TG UT WOS:000265862900003 PM 19278824 ER PT J AU McKenzie, AL Goldman, S Barrango, C Shrime, M Wong, T Byl, N AF McKenzie, Alison L. Goldman, Sarah Barrango, Cindy Shrime, Maria Wong, Tricia Byl, Nancy TI Differences in Physical Characteristics and Response to Rehabilitation for Patients with Hand Dystonia: Musicians' Cramp Compared to Writers' Cramp SO JOURNAL OF HAND THERAPY LA English DT Review ID TRANSCRANIAL MAGNETIC STIMULATION; MOTOR CORTEX EXCITABILITY; PRIMARY SOMATOSENSORY CORTEX; REPETITIVE STRAIN INJURY; TASK-SPECIFIC DYSTONIA; PRIMARY WRITING TREMOR; FOCAL DYSTONIA; INTRACORTICAL INHIBITION; BOTULINUM TOXIN; SENSORIMOTOR INTEGRATION AB Study Design: Pre-Post, Mixed Factorial Trial. Introduction: Focal hand dystonia is a challenging movement disorder to rehabilitate in musicians and writers. Purpose of the Study: To compare the neuromusculoskeletal characteristics of those with writers' cramp (WC) and musicians' cramp (MC), and evaluate responsiveness to learning-based sensorimotor training. Methods: Twenty-seven individuals (14 musicians, 13 writers) participated in 8 weeks of supervised therapy supplemented with a home program. Between-group differences on measures of musculoskeletal (physical), sensory, and motor performance were evaluated at baseline and post-intervention. Results: Subjects with MC had a higher level of functional independence and better range of motion, but less strength in the affected upper limb than those of subjects with WC. Subjects with MC demonstrated greater accuracy on graphesthesia, kinesthesia, and localization at baseline. No between-group differences in motor performance were noted at baseline or post-intervention. Following individually adapted learning-based sensorimotor training, both groups improved in musculoskeletal (physical) parameters, sensory processing, and motor control; however, improvements on certain subtests differed by group. At follow-up, differences in posture, ROM, strength, graphesthesia, and kinesthesia persisted between the groups. Conclusions: Subjects with WC have different physical and performance risk factors compared with those of subjects with MC. Intervention paradigms are efficacious, but variable responses to rehabilitation occur. Level of Evidence: 4. J HAND THER. 2009;22:172-82. C1 [McKenzie, Alison L.; Barrango, Cindy; Shrime, Maria; Wong, Tricia] Chapman Univ, Dept Phys Therapy, Orange, CA 92624 USA. [Goldman, Sarah] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA USA. [Byl, Nancy] Univ Calif San Francisco, Dept Phys Therapy & Rehabil Sci, San Francisco, CA 94143 USA. RP McKenzie, AL (reprint author), Chapman Univ, Dept Phys Therapy, 1 Univ Dr, Orange, CA 92624 USA. EM amckenzie@chapman.edu NR 102 TC 12 Z9 12 U1 2 U2 8 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 EI 1545-004X J9 J HAND THER JI J. Hand Ther. PD APR-JUN PY 2009 VL 22 IS 2 SI SI BP 172 EP 181 DI 10.1016/j.jht.2008.12.006 PG 10 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA 442TG UT WOS:000265862900009 PM 19389604 ER PT J AU Derksen, C Sturm, M Liston, GE Holmgren, J Huntington, H Silis, A Solie, D AF Derksen, Chris Sturm, Matthew Liston, Glen E. Holmgren, Jon Huntington, Henry Silis, Arvids Solie, Daniel TI Northwest Territories and Nunavut Snow Characteristics from a Subarctic Traverse: Implications for Passive Microwave Remote Sensing SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID WATER EQUIVALENT; LAYERED SNOWPACKS; WESTERN CANADA; EMISSION MODEL; SEASONAL SNOW; DEPTH; ALASKA; COVER; PRECIPITATION; BOREAL AB During April 2007, a coordinated series of snow measurements was made across the Northwest Territories and Nunavut, Canada, during a snowmobile traverse from Fairbanks, Alaska, to Baker Lake, Nunavut. The purpose of the measurements was to document the general nature of the snowpack across this region for the evaluation of satellite-and model-derived estimates of snow water equivalent (SWE). Although detailed, local snow measurements have been made as part of ongoing studies at tundra field sites (e. g., Daring Lake and Trail Valley Creek in the Northwest Territories; Toolik Lake and the Kuparak River basin in Alaska), systematic measurements at the regional scale have not been previously collected across this region of northern Canada. The snow cover consisted of depth hoar and wind slab with small and ephemeral fractions of new, recent, and icy snow. The snow was shallow (<40 cm deep), usually with fewer than six layers. Where snow was deposited on lake and river ice, it was shallower, denser, and more metamorphosed than where it was deposited on tundra. Although highly variable locally, no longitudinal gradients in snow distribution, magnitude, or structure were detected. This regional homogeneity allowed us to identify that the observed spatial variability in passive microwave brightness temperatures was related to subgrid fractional lake cover. Correlation analysis between lake fraction and Advanced Microwave Scanning Radiometer for Earth Observing System (AMSR-E) brightness temperature showed frequency dependent, seasonally evolving relationships consistent with lake ice drivers. Simulations of lake ice thickness and snow depth on lake ice produced from the Canadian Lake Ice Model (CLIMo) indicated that at low frequencies (6.9, 10.7 GHz), correlations with lake fraction were consistent through the winter season, whereas at higher frequencies (18.7, 36.5 GHz), the strength and direction of the correlations evolved consistently with the penetration depth as the influence of the subice water was replaced by emissions from the ice and snowpack. A regional rain-on-snow event created a surface ice lens that was detectable using the AMSR-E 36.5-GHz polarization gradient due to a strong response at the horizontal polarization. The appropriate polarization for remote sensing of the tundra snowpack depends on the application: horizontal measurements are suitable for ice lens detection; vertically polarized measurements are appropriate for deriving SWE estimates. C1 [Derksen, Chris; Silis, Arvids] Environm Canada, Div Climate Res, Toronto, ON M3H 5TA, Canada. [Sturm, Matthew; Holmgren, Jon] USA, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. [Liston, Glen E.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA. [Huntington, Henry] Huntington Consulting, Anchorage, AK USA. [Solie, Daniel] Univ Alaska Fairbanks, Fairbanks, AK USA. RP Derksen, C (reprint author), Environm Canada, Div Climate Res, 4905 Dufferin St, Toronto, ON M3H 5TA, Canada. EM Chris.Derksen@ec.gc.ca FU National Science Foundation; Cold Regions Research and Engineering Laboratory; Environment Canada. Essential logistical FX SnowSTAR-2007 was supported by the National Science Foundation, the Cold Regions Research and Engineering Laboratory, and Environment Canada. Essential logistical and navigational support was graciously provided by numerous people in all the communities along the traverse route. Thanks to Claude Duguay and Patrick Menard for the CLIMo simulations. AMSR-E brightness temperatures were acquired from the National Snow and Ice Data Center, Boulder, Colorado. Thanks to three anonymous reviewers for their constructive comments. NR 51 TC 29 Z9 30 U1 2 U2 9 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD APR PY 2009 VL 10 IS 2 BP 448 EP 463 DI 10.1175/2008JHM1074.1 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 439PQ UT WOS:000265639900006 ER PT J AU Bautista, CT Pando, MA Reynaga, E Marone, R Sateren, WB Montano, SM Sanchez, JL Avila, MM AF Bautista, Christian T. Pando, Maria A. Reynaga, Elena Marone, Ruben Sateren, Warren B. Montano, Silvia M. Sanchez, Jose L. Avila, Maria M. TI Sexual Practices, Drug Use Behaviors, and Prevalence of HIV, Syphilis, Hepatitis B and C, and HTLV-1/2 in Immigrant and Non-immigrant Female Sex Workers in Argentina SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH LA English DT Article DE Immigrant; Migration; Risk; Behavior; Sex worker; HIV; STI; Argentina ID AMERICA AB Objective To study socio-demographics, sexual practices, drug use behaviors, and prevalences of HIV, syphilis, hepatitis B and C, HTLV-1 and HTLV-2 in immigrant (foreigner) and non-immigrant (local/native) female sex workers (FSW). Design This was a cross-sectional study in immigrant and non-immigrant FSW living in Buenos Aires, Argentina. Participants were interviewed using a standardized questionnaire. Results A total of 625 FSW were enrolled, of whom 169 (27%) were immigrant FSW from Paraguay, the Dominican Republic, Brazil, Peru, and Uruguay. The prevalence of syphilis and hepatitis C was significantly higher among Argentinean FSW than among immigrant FSW. However, hepatitis B prevalence was higher among immigrant FSW. Adjusted risk factor analysis comparing immigrant FSW with Argentinean FSW indicated that marital status (single), occupation (none), fee per sex act (<= US$ 7), workplace (bar and cabaret), and anal sex with clients were significantly associated with immigrant FSW status. Conclusions Effective HIV/STI prevention and medical care programs need to be tailored to the specific needs of both FSW groups in Argentina. C1 [Bautista, Christian T.; Sateren, Warren B.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD 20850 USA. [Bautista, Christian T.; Montano, Silvia M.; Sanchez, Jose L.] US Naval Med Res Ctr Detachment, Lima, Peru. [Pando, Maria A.; Avila, Maria M.] Univ Buenos Aires, Fac Med, Dept Microbiol, Ctr Nacl Referencia SIDA, Buenos Aires, DF, Argentina. [Pando, Maria A.] Univ Maryland, Inst Biotechnol, Inst Human Virol, Baltimore, MD 21201 USA. [Reynaga, Elena] Asociac Mujeres Meretrices Argentina, Buenos Aires, DF, Argentina. [Marone, Ruben] Asociac Civil, NEXO, Buenos Aires, DF, Argentina. [Sanchez, Jose L.] Walter Reed Army Inst Res, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD USA. [Sanchez, Jose L.] Henry M Jackson Fdn Advancement Mil Med Inc, Rockville, MD USA. [Avila, Maria M.] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina. RP Bautista, CT (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. EM cbautista@hivresearch.org RI Bautista, Christian/B-2812-2011; Valle, Ruben/A-7512-2013 NR 16 TC 13 Z9 14 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1557-1912 J9 J IMMIGR MINOR HEALT JI J. Immigr. Minor. Health PD APR PY 2009 VL 11 IS 2 BP 99 EP 104 DI 10.1007/s10903-007-9114-2 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 645ZN UT WOS:000281504800004 PM 18175218 ER PT J AU Crowe, SR Engler, RJM Ballard, JD Harley, JB Farris, AD James, JA AF Crowe, Sherry R. Engler, Renata J. M. Ballard, Jimmy D. Harley, John B. Farris, A. Darise James, Judith A. TI Characterization of the anti-lethal factor (LF) antibody response in Anthrax Vaccine Adsorbed (AVA) individuals SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 [Crowe, Sherry R.; Harley, John B.; Farris, A. Darise; James, Judith A.] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. [Engler, Renata J. M.] Walter Reed Army Med Ctr, Washington, DC USA. [Ballard, Jimmy D.; Harley, John B.; Farris, A. Darise; James, Judith A.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2009 VL 182 SU 1 MA 132.15 PG 1 WC Immunology SC Immunology GA V44QN UT WOS:000209763602225 ER PT J AU Dye, JM Muhammad, M Bakken, R Barth, J Kuehne, A Olinger, GG AF Dye, John M. Muhammad, Majidat Bakken, Russell Barth, James Kuehne, Ana Olinger, Gene G. TI Protection of cynomolgus macaques from Ebola Sudan infection SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 [Dye, John M.; Muhammad, Majidat; Bakken, Russell; Barth, James; Kuehne, Ana; Olinger, Gene G.] US Army, Med Res Inst Infect Dis, Virol Div, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2009 VL 182 SU 1 MA 45.10 PG 2 WC Immunology SC Immunology GA V44QN UT WOS:000209763600381 ER PT J AU Lear, CM Olinger, GG AF Lear, Calli Marie Olinger, Gene G. TI Assessment of Ebola Specific Antibody Responses in Vaccinated Macaques SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 [Lear, Calli Marie; Olinger, Gene G.] US Army Med Res Inst Infect Dis, Dept Virol, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2009 VL 182 SU 1 MA 128.20 PG 1 WC Immunology SC Immunology GA V44QN UT WOS:000209763602133 ER PT J AU Moratz, CM Egan, R Zacharia, A Simovic, M Gist, I Lucca, JD Tsokos, GC AF Moratz, Chantal M. Egan, R. Zacharia, A. Simovic, M. Gist, I. Lucca, J. Dalle Tsokos, G. C. TI Delineation of hypoxia versus inflammatory contributions to tissue injury by attenuation of G-alpha-i signaling SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 [Moratz, Chantal M.; Simovic, M.; Gist, I.; Lucca, J. Dalle] Walter Reed Army Inst Res, CI MCR, Sliver Spring, MD USA. [Egan, R.; Zacharia, A.] Uniform Serv Univ Hlth Sci, APG, Bethesda, MD USA. [Tsokos, G. C.] Harvard Med Sch, Rheumatol Div, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2009 VL 182 SU 1 MA 93.7 PG 1 WC Immunology SC Immunology GA V44QN UT WOS:000209763601443 ER PT J AU Saikh, KU Kissner, TL Cisney, ED Ruthel, G Ulrich, RG AF Saikh, Kamal U. Kissner, Teri L. Cisney, Emily D. Ruthel, Gordon Ulrich, Robert G. TI Induction of MyD88-Dependent Pro-inflammatory Cytokines Contributes to Lethal Toxicity of Staphylococcal Enterotoxins in Mice SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 [Saikh, Kamal U.; Kissner, Teri L.; Cisney, Emily D.; Ruthel, Gordon; Ulrich, Robert G.] US Army Med Res Inst Infect Dis, Dept Immunol, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 2009 VL 182 SU 1 MA 135.13 PG 1 WC Immunology SC Immunology GA V44QN UT WOS:000209763602432 ER PT J AU Patel, GK Yee, CL Montemarano, A Maggio, K Vogel, JC AF Patel, G. K. Yee, C. L. Montemarano, A. Maggio, K. Vogel, J. C. TI CD133 identifies human cutaneous squamous cell carcinoma tumor initiating cells SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract CT 69th Annual Meeting of the Society-of-Investigative-Dermatology CY MAY 06-09, 2009 CL Montreal, CANADA SP Soc Investigat Dematol C1 [Patel, G. K.] Cardiff Univ, Sch Med, Cardiff, S Glam, Wales. [Patel, G. K.; Yee, C. L.; Vogel, J. C.] NCI, Dermatol Branch, Bethesda, MD 20892 USA. [Montemarano, A.] Rockledge Skin Canc Clin, Bethesda, MD USA. [Maggio, K.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 2009 VL 129 MA 155 BP S26 EP S26 PG 1 WC Dermatology SC Dermatology GA 430MU UT WOS:000264994000153 ER PT J AU McCarthy, M Waits, CM Ghodssi, R AF McCarthy, Matthew Waits, C. Mike Ghodssi, Reza TI Dynamic Friction and Wear in a Planar-Contact Encapsulated Microball Bearing Using an Integrated Microturbine SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Microballs; microelectromechanical systems (MEMS) bearings; microturbines; rolling friction; spin-down ID MICROMOTORS; DESIGN AB The demonstration and characterization of a novel planar-contact encapsulated microball bearing using a radial inflow microturbine are presented. Stable operation of the air-driven silicon microturbine is shown for over 1000 000 revolutions at speeds, pressure drops, and flow rates of up to 10000 r/min, 0.45 lbf/in(2), and 3.5 slm, respectively. Incorporation of a gas thrust plenum using a novel packaging scheme has enabled comprehensive spin-down friction characterization of the encapsulated microball bearing. An empirical power-law model for dynamic friction has been developed for speeds of 250-5000 r/min and loads of 10-50 mN, corresponding to torques of 0.0625-2.5 mu N . m and friction torque constants of 2.25-5.25 x 10(-4) mu N . m/r/min. The onset and effect of wear and wear debris have been studied, showing negligible wear in the load bearing surfaces for the operating conditions considered. C1 [McCarthy, Matthew; Ghodssi, Reza] Univ Maryland, Syst Res Inst, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA. [Waits, C. Mike] USA, Res Lab, Adelphi, MD 20783 USA. RP McCarthy, M (reprint author), MIT, Dept Mech Engn, Cambridge, MA 02139 USA. EM mattmcc@umd.edu; cwaits@arl.army.mil; ghodssi@umd.edu FU U.S. Army Research Laboratory [CA W911NF-05-2-0026] FX Manuscript received April 28, 2008; revised November 21 2008. First published February 24, 2009; current version published April, 2009. This work was supported by the U.S. Army Research Laboratory under Grant CA#W911NF-05-2-0026. Subject Editor L. Lin. NR 28 TC 22 Z9 22 U1 1 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 EI 1941-0158 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD APR PY 2009 VL 18 IS 2 BP 263 EP 273 DI 10.1109/JMEMS.2009.2013407 PG 11 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 431US UT WOS:000265090300004 ER PT J AU Mosher, L Waits, CM Morgan, B Ghodssi, R AF Mosher, Lance Waits, Christopher M. Morgan, Brian Ghodssi, Reza TI Double-Exposure Grayscale Photolithography SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Grayscale lithography; microelectromechanical systems (MEMS); micromachining; three-dimensional (3-D) lithography ID GRAY-SCALE LITHOGRAPHY; SILICON MEMS STRUCTURES; FABRICATION; MICROFABRICATION; TECHNOLOGY; BEAM; PHOTORESIST; SU-8 AB A double-exposure grayscale photolithography technique is developed and demonstrated to produce three-dimensional (3-D) structures with a high vertical resolution. Pixelated grayscale masks often suffer from limited vertical resolution due to restrictions on the mask fabrication. The double-exposure technique uses two pixelated grayscale mask exposures before development and dramatically increases the vertical resolution without altering the mask fabrication process. An empirical calibration technique was employed for mask design and was also applied to study the effects of exposure time and mask misalignment on the photoresist profile. This technology has been demonstrated to improve the average step between photoresist levels from 0.19 to 0.02 mu m and the maximum step from 0.43 to 0.2 mu m compared to a single pixelated exposure using the same mask design. C1 [Mosher, Lance] Lockheed Martin Space Syst Co, Newtown, PA 19104 USA. [Waits, Christopher M.; Morgan, Brian] USA, Res Lab, Adelphi, MD 20783 USA. [Ghodssi, Reza] Univ Maryland, Syst Res Inst, Dept Elect & Comp Engn, MEMS Sensors & Actuators Lab, College Pk, MD 20742 USA. RP Mosher, L (reprint author), Lockheed Martin Space Syst Co, Newtown, PA 19104 USA. EM lance.mosher@lmco.com FU U.S. Army Research Laboratory Collaborative Technology Alliance, Power and Energy Program; NASA Goddard Space Flight Center FX Manuscript received June 24, 2008; revised September 15, 2008. First published February 13, 2009; current version published April 1, 2009. This work was supported in part by the U.S. Army Research Laboratory Collaborative Technology Alliance, Power and Energy Program, and in part by the NASA Goddard Space Flight Center. Subject Editor K. E. Petersen. NR 28 TC 22 Z9 22 U1 2 U2 17 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 EI 1941-0158 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD APR PY 2009 VL 18 IS 2 BP 308 EP 315 DI 10.1109/JMEMS.2008.2011703 PG 8 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 431US UT WOS:000265090300008 ER PT J AU Borch, FL AF Borch, Fred L. TI Lincoln and the Court. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Borch, Fred L.] Judge Advocate Gen Legal Ctr, Charlottesville, VA USA. [Borch, Fred L.] USA, Judge Advocate Gen Sch, Charlottesville, VA 22901 USA. RP Borch, FL (reprint author), Judge Advocate Gen Legal Ctr, Charlottesville, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2009 VL 73 IS 2 BP 648 EP 650 PG 3 WC History SC History GA 434HB UT WOS:000265264700031 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Targeting Civilians in War. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2009 VL 73 IS 2 BP 661 EP 662 PG 2 WC History SC History GA 434HB UT WOS:000265264700039 ER PT J AU Mihara, RY AF Mihara, Robert Y. TI Moroland, 1899-1906: America's First Attempt to Transform an Islamic Society. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Mihara, Robert Y.] US Mil Acad, West Point, NY 10996 USA. RP Mihara, RY (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2009 VL 73 IS 2 BP 663 EP 664 PG 2 WC History SC History GA 434HB UT WOS:000265264700040 ER PT J AU House, JM AF House, Jonathan M. TI The Myth of the Eastern Front: The Nazi-Soviet War in American Popular Culture. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2009 VL 73 IS 2 BP 681 EP 682 PG 2 WC History SC History GA 434HB UT WOS:000265264700052 ER PT J AU Bourque, SA AF Bourque, Stephen A. TI Defeat and Triumph: The Story of a Controversial Allied Invasion and French Rebirth. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bourque, Stephen A.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Bourque, SA (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2009 VL 73 IS 2 BP 685 EP 686 PG 2 WC History SC History GA 434HB UT WOS:000265264700055 ER PT J AU Linkov, I Steevens, J Adlakha-Hutcheon, G Bennett, E Chappell, M Colvin, V Davis, JM Davis, T Elder, A Hansen, S Hakkinen, PB Hussain, SM Karkan, D Korenstein, R Lynch, I Metcalfe, C Ramadan, AB Satterstrom, FK AF Linkov, Igor Steevens, Jeffery Adlakha-Hutcheon, Gitanjali Bennett, Erin Chappell, Mark Colvin, Vicki Davis, J. Michael Davis, Thomas Elder, Alison Foss Hansen, Steffen Hakkinen, Pertti Bert Hussain, Saber M. Karkan, Delara Korenstein, Rafi Lynch, Iseult Metcalfe, Chris Ramadan, Abou Bakr Satterstrom, F. Kyle TI Emerging methods and tools for environmental risk assessment, decision-making, and policy for nanomaterials: summary of NATO Advanced Research Workshop SO JOURNAL OF NANOPARTICLE RESEARCH LA English DT Editorial Material DE Nanomaterials; Risk assessment; Decision analysis; Regulatory policy; Uncertainty analysis; Nanotechnology governance; Societal implications ID CARBON NANOTUBES; NANOPARTICLES; NANOTECHNOLOGY; IDENTIFICATION; NANOTOXICOLOGY; ULTRAFINE; PROTEINS; WATER AB Nanomaterials and their associated technologies hold promising opportunities for the development of new materials and applications in a wide variety of disciplines, including medicine, environmental remediation, waste treatment, and energy conservation. However, current information regarding the environmental effects and health risks associated with nanomaterials is limited and sometimes contradictory. This article summarizes the conclusions of a 2008 NATO workshop designed to evaluate the wide-scale implications (e.g., benefits, risks, and costs) of the use of nanomaterials on human health and the environment. A unique feature of this workshop was its interdisciplinary nature and focus on the practical needs of policy decision makers. Workshop presentations and discussion panels were structured along four main themes: technology and benefits, human health risk, environmental risk, and policy implications. Four corresponding working groups (WGs) were formed to develop detailed summaries of the state-of-the-science in their respective areas and to discuss emerging gaps and research needs. The WGs identified gaps between the rapid advances in the types and applications of nanomaterials and the slower pace of human health and environmental risk science, along with strategies to reduce the uncertainties associated with calculating these risks. C1 [Linkov, Igor] USA, Environm Lab, Corps Engineers, Brookline, MA 02446 USA. [Steevens, Jeffery] USA, Erdc, Vicksburg, MS 39056 USA. [Adlakha-Hutcheon, Gitanjali] Def Res & Dev Canada, Ottawa, ON K1A 0K2, Canada. [Bennett, Erin] Intertox Inc, Salem, MA 01970 USA. [Chappell, Mark] USA, Environm Lab, Corps Engineers, Vicksburg, MS 39056 USA. [Colvin, Vicki] Rice Univ, ICON, Houston, TX 77005 USA. [Davis, J. Michael] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA. [Davis, Thomas] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada. [Elder, Alison] Univ Rochester, Dept Environm Med, Rochester, NY 14610 USA. [Foss Hansen, Steffen] Tech Univ Denmark, Dept Environm Engn, NanoDTU, DK-2800 Lyngby, Denmark. [Davis, Thomas] Environm Canada, Montreal, PQ H3C 3J7, Canada. [Hussain, Saber M.] USAF, Res Lab, Dayton, OH USA. [Karkan, Delara] Hlth Canada, Ottawa, ON K1A 0L2, Canada. [Korenstein, Rafi] Tel Aviv Univ, Marian Gertner Inst Med Nanosyst, Dept Physiol & Pharmacol, Fac Med, IL-69978 Tel Aviv, Israel. [Lynch, Iseult] Univ Coll Dublin, Sch Chem & Chem Biol, Irish Ctr Colloid Sci & Biomat, Dublin 2, Ireland. [Metcalfe, Chris] Trent Univ, Peterborough, ON K9J 7B8, Canada. [Ramadan, Abou Bakr] Natl Egyptian Environm & Radiat Monitoring Networ, Nasr City 11672, Cairo, Egypt. [Satterstrom, F. Kyle] Harvard Univ, Sch Engn & Appl Sci, Engn Sci Lab 224, Cambridge, MA 02138 USA. [Bennett, Erin] Bioengn Grp, Salem, MA 01970 USA. RP Linkov, I (reprint author), USA, Environm Lab, Corps Engineers, 83 Winchester St Suite 1, Brookline, MA 02446 USA. EM Igor.Linkov@usace.army.mil; Jeffery.A.Steevens@us.army.mil; Gitanjali.Adlakha-Hutcheon@drdc-rddc.gc.ca; ebennett@bioengineering.com; Mark.a.chappell@usace.army.mil; colvin@rice.edu; Davis.Jmichael@epa.gov; ta.davis@umontreal.ca; Alison_Elder@urmc.rochester.edu; sfh@er.dtu.dk; berthakkinen@gmail.com; Saber.Hussain@wpafb.af.mil; Delara_karkan@hc-sc.gc.ca; korens@post.tau.ac.il; iseult@fiachra.ucd.ie; cmetcalfe@trentu.ca; ramadan58@yahoo.com; satterst@fas.harvard.edu RI Davis, J Michael/B-3337-2009; Hakkinen, Pertti/G-4803-2016; Lynch, Iseult/I-3915-2014 OI Hakkinen, Pertti/0000-0002-8295-9738; Lynch, Iseult/0000-0003-4250-4584 NR 42 TC 45 Z9 45 U1 3 U2 40 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-0764 J9 J NANOPART RES JI J. Nanopart. Res. PD APR PY 2009 VL 11 IS 3 BP 513 EP 527 DI 10.1007/s11051-008-9514-9 PG 15 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 413MR UT WOS:000263797700001 ER PT J AU Piva, SR Childs, JD Klucinec, BM Irrgang, JJ Almeida, GJM Fitzgerald, GK AF Piva, Sara R. Childs, John D. Klucinec, Brian M. Irrgang, James J. Almeida, Gustavo J. M. Fitzgerald, G. Kelley TI Patella Fracture During Rehabilitation After Bone-Patellar Tendon-Bone Anterior Cruciate Ligament Reconstruction: 2 Case Reports SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE ACL; failure; knee; load; strain ID QUADRICEPS FEMORIS MUSCLE; PATELLOFEMORAL CONTACT AREAS; CLOSED-KINETIC-CHAIN; 2-YEAR FOLLOW-UP; ACL RECONSTRUCTION; TIBIAL TRANSLATION; QUANTITATIVE-EVALUATION; ELECTRICAL-STIMULATION; STRAIN BEHAVIOR; SURFACE STRAIN AB STUDY DESIGN: Case report. BACKGROUND: Patellar fracture is a rare but significant complication following anterior cruciate ligament (ACL) reconstruction when using a bone-patellar tendon-bone (BPTB) autograft. The purpose of these case reports is to describe 2 cases in which patellar fracture occurred during rehabilitation CASE DESCRIPTION: Both patients were 23-year-old males referred for rehabilitation after ACL reconstruction using a BPTB autograft. They were both progressing satisfactorily in rehabilitation until sustaining a fracture of the patella. One fracture occurred during the performance of the eccentric phase of a knee extension exercise during the sixth week of rehabilitation (7 weeks postsurgery), whereas the other fracture occurred during testing of the patient's quadriceps maximum voluntary isometric contraction in the ninth week of rehabilitation (10 weeks postsurgery). Both patients were subsequently treated with open reduction and internal fixation of the patella. DISCUSSION: During rehabilitation following ACL reconstruction using BPTB autograft, clinicians should consider the need to balance the sometimes-competing goals of improving quadriceps strength while providing protection to the healing graft, minimization of patellofemoral pain, and protection of the patellar donor site. C1 [Piva, Sara R.; Irrgang, James J.; Almeida, Gustavo J. M.; Fitzgerald, G. Kelley] Univ Pittsburgh, Pittsburgh, PA USA. [Childs, John D.] US Army Baylor Univ, Houston, TX USA. [Klucinec, Brian M.] Ctr Manager Hershey Ctr, Drayer Phys Therapy Inst, Clearfield, PA USA. RP Piva, SR (reprint author), 6035 Forbes Tower, Pittsburgh, PA 15260 USA. EM spiva@pitt.edu RI ALMEIDA, GUSTAVO J./M-8442-2015 OI ALMEIDA, GUSTAVO J./0000-0003-4041-2651 NR 75 TC 7 Z9 9 U1 1 U2 2 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD APR PY 2009 VL 39 IS 4 BP 278 EP 286 DI 10.2519/jospt.2009.2864 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 434BE UT WOS:000265249400006 PM 19346622 ER PT J AU Gerber, JP AF Gerber, J. Parry TI Pigmented Villonodular Synovitis in a Military Trainee With Ankle Pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Gerber, J. Parry] US Army Baylor Univ Postgrad Sports Med Residency, Ft Sam Houston, TX USA. [Gerber, J. Parry] Keller Army Community Hosp, US Mil Acad, West Point, NY USA. RP Gerber, JP (reprint author), US Army Baylor Univ Postgrad Sports Med Residency, Ft Sam Houston, TX USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD APR PY 2009 VL 39 IS 4 BP 296 EP 296 DI 10.2519/jospt.2009.0404 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 434BE UT WOS:000265249400008 PM 19346629 ER PT J AU Masini, BD Waterman, SM Wenke, JC Owens, BD Hsu, JR Ficke, JR AF Masini, Brendan D. Waterman, Scott M. Wenke, Joseph C. Owens, Brett D. Hsu, Joseph R. Ficke, James R. TI Resource Utilization and Disability Outcome Assessment of Combat Casualties From Operation Iraqi Freedom and Operation Enduring Freedom SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE combat wounds; cost; disability; extremity; resources ID EXTREMITY INJURIES; BODY ARMOR; TRAUMA; RECONSTRUCTION; IMPACT; WOUNDS; AMPUTATION; SEVERITY AB Objectives: Injuries are common during combat operations. The high costs of extremity injuries both in resource utilization and disability are well known in the civilian sector. We hypothesized that, similarly combat-related extremity injuries, when compared with other injures from the current conflicts in Iraq and Afghanistan, require the largest percentage of medical resources, account for the greatest number of disabled soldiers, and have greater costs of disability benefits. Design: Descriptive epidemiologic study and cost analysis. Methods: The Department of Defense Medical Metrics (M2) database was queried for the hospital admissions and billing data of a previously published cohort of soldiers injured in Iraq and Afghanistan between October 2001 and January 2005 and identified from the Joint Theater Trauma Registry. The US Army Physical Disability Administration database was also queried for Physical Evaluation Board outcomes for these soldiers, allowing calculation of disability benefit cost. Primary body region injured was assigned using billing records that gave a primary diagnosis International Classification of Diseases Ninth Edition code, which was corroborated with Joint Theater Trauma Registry injury mechanisms and descriptions for accuracy Results: A total of 1333 soldiers had complete admission data and were included from 1566 battle injuries not returned to duty of 3 102 total casualties. Extremity-injured patients had the longest average inpatient stay at 10.7 days, accounting for 65% of the $65.3-million total inpatient resource utilization. 64% of the 464 patients found "unfit for duty," and 64% of the $170-million total projected disability benefit costs. Extrapolation of data yields total disability costs for this conflict, approaching $2 billion. Conclusions: Combat-related extremity injuries require the greatest utilization of resources for inpatient treatment in tire initial postinjury period, cause the greatest number of disabled soldiers, and have tire greatest projected disability benefit costs. This study highlights the need for continued or increased funding and support for military orthopaedic Surgeons and extremity trauma research efforts. C1 [Masini, Brendan D.; Waterman, Scott M.; Wenke, Joseph C.] USA, Inst Surg Res, Regenerat Med Task Area, Ft Sam Houston, TX 78234 USA. [Owens, Brett D.] William Beaumont Army Med Ctr, Dept Orthopaed, El Paso, TX 79920 USA. RP Masini, BD (reprint author), USA, Inst Surg Res, Regenerat Med Task Area, 3400 Rawley Chambers Rd, Ft Sam Houston, TX 78234 USA. EM brendan.masini@amedd.army.mil NR 28 TC 69 Z9 69 U1 1 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD APR PY 2009 VL 23 IS 4 BP 261 EP 266 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 425AR UT WOS:000264609900005 PM 19318869 ER PT J AU Cohen, SP Wang, SX Chen, LC Kurihara, C McKnight, G Marcuson, M Mao, JR AF Cohen, Steven P. Wang, Shuxing Chen, Lucy Kurihara, Connie McKnight, Geselle Marcuson, Matthew Mao, Jianren TI An Intravenous Ketamine Test as a Predictive Response Tool in Opioid-Exposed Patients with Persistent Pain SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT LA English DT Article DE Dextromethorphan; infusion test; ketamine; N-methyl-D-aspartate; opioid; predictive value; tolerance ID ORAL DEXTROMETHORPHAN TREATMENT; ASPARTATE RECEPTOR ANTAGONISTS; NEUROPATHIC PAIN; DOUBLE-BLIND; CANCER PAIN; POSTHERPETIC NEURALGIA; FIBROMYALGIA SYNDROME; SUBSEQUENT RESPONSE; DIABETIC-NEUROPATHY; TEMPORAL SUMMATION AB Chronic pain patients who are treated with opioid therapy represent a significant challenge to medical professionals. When. pain recurs in the face of a, previously effective opioid regimen, treatment options include (lose escalation., opioid rotation, drug holidays, and the addition Of adjuvants. Some experts advocate the use of N-methyl-D-aspartate receptor (NMDA-R) antagonists to combat tolerance. Recently the use of an, intravenous (i.v.) ketamine infusion to Predict the response to a dextromethorphan (DX) treatment trial has been described. In this study, 56 opioid-exposed patients with recurrent pain were treated with a low-dose (0.1 mg/kg) i.v. ketamine test followed by a DX treatment course. Using previously designated cutoff values for a positive response to ketamine (67% or more pain relief) and DX (50% or more pain relief), the sensitivity, specificity, positive predictive value, and negative Predictive value for an i.v. ketamine infusion to predict subsequent response to DX treatment were 72%, 68%, 52%, and 85%, respectively. The observed agreement between. an.,algesic responses was 78%, indicating a highly significant correlation (r = 0.54, P = 0.0001). Subgroup classification in the response to either ketamine or DX classification revealed no significant differences treatment, based on pain classification (i.e., nociceptive, neuropathic, or mixed) or placebo response. In contrast, a weaker correlation between ketamine and DX response was found in subjects requiring high-dose rather than low-dose opioid therapy. A significant correlation also was noted between. the development of side effects for the two NMDA-R antagonists. Based on These results, we conclude that an i.v. ketamine test may be a valuable toot in predicting subsequent response to DX treatment in opioid-exposed patients. with Persistent pain, J Pain Symptom Manage 2009;37:698-708. (C) 2009 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved. C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Pain Management Div, Baltimore, MD USA. [Marcuson, Matthew] Natl Naval Med Ctr, Bethesda, MD USA. [Cohen, Steven P.; Kurihara, Connie; McKnight, Geselle] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Wang, Shuxing; Chen, Lucy; Mao, Jianren] Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, MGH Ctr Translat Pain Res, Boston, MA 02114 USA. RP Cohen, SP (reprint author), Johns Hopkins Pain Management Div, 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu NR 48 TC 9 Z9 9 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0885-3924 EI 1873-6513 J9 J PAIN SYMPTOM MANAG JI J. Pain Symptom Manage. PD APR PY 2009 VL 37 IS 4 BP 698 EP 708 DI 10.1016/j.jpainsymman.2008.03.018 PG 11 WC Health Care Sciences & Services; Medicine, General & Internal; Clinical Neurology SC Health Care Sciences & Services; General & Internal Medicine; Neurosciences & Neurology GA 433SH UT WOS:000265225600010 PM 18789637 ER PT J AU Moss, PL Au, G Plichta, EJ Zheng, JP AF Moss, P. L. Au, G. Plichta, E. J. Zheng, J. P. TI Investigation of solid electrolyte interfacial layer development during continuous cycling using ac impedance spectra and micro-structural analysis SO JOURNAL OF POWER SOURCES LA English DT Article; Proceedings Paper CT 14th International Meeting on Lithium Batteries CY JUN 22-28, 2008 CL Tianjin, PEOPLES R CHINA SP Tianjin Inst Power Sources, China Ind Assoc Power Sources, Tianjin Local Govt DE Solid-electrolyte interfacial layer; ac impedance; Cycling performance; Lithium polymer battery ID LITHIUM-ION BATTERIES; ELECTROCHEMICAL PROPERTIES; MESOCARBON MICROBEADS; RECHARGEABLE BATTERY; POLYMER ELECTROLYTE; ANODE MATERIAL; FILM; PERFORMANCE; CARBON; RESISTANCE AB The formation of passivating surface films on the electrodes of a lithium-ion polymer battery was investigated at various cycling state using ac impedance spectroscopy and scanning electron microscopy (SEM). A sealed commercial cell (Sony Co.) with a nominal capacity of 840 mAh was used for the experiment. An equivalent circuit used to model the impedance spectra show that, with continuous cycling there is a relatively large increase in the interfacial impedance and charge transfer resistances after a few hundred charge-discharge cycles. It was observed that the cell capacity decrease with increase cell impedance. SEM analysis on the electrodes shows that during continuous charge-discharge cycling, the deposition of sub-micro-size particles and dissolution of surface films on the graphite surface. This observation is consistent with increase in cell impedance as a function of charge/discharge cycling. (C) 2008 Elsevier B.V. All rights reserved. C1 [Moss, P. L.; Zheng, J. P.] Florida A&M Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. [Moss, P. L.; Zheng, J. P.] Florida State Univ, Tallahassee, FL 32310 USA. [Au, G.; Plichta, E. J.] USA, CERDEC, Ft Monmouth, NJ 07703 USA. [Zheng, J. P.] Florida State Univ, Ctr Adv Power Syst, Tallahassee, FL 32310 USA. RP Zheng, JP (reprint author), Florida A&M Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. EM zheng@eng.fsu.edu NR 24 TC 38 Z9 38 U1 2 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD APR 1 PY 2009 VL 189 IS 1 BP 66 EP 71 DI 10.1016/j.jpowsour.2008.11.048 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 435BG UT WOS:000265317600012 ER PT J AU Spiering, BA Kraemer, WJ Vingren, JL Ratamess, NA Anderson, JM Armstrong, LE Nindl, BC Volek, JS Hakkinen, K Maresh, CM AF Spiering, Barry A. Kraemer, William J. Vingren, Jakob L. Ratamess, Nicholas A. Anderson, Jeffrey M. Armstrong, Lawrence E. Nindl, Bradley C. Volek, Jeff S. Hakkinen, Keijo Maresh, Carl M. TI Elevated endogenous testosterone concentrations potentiate muscle androgen receptor responses to resistance exercise SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY LA English DT Article DE Anabolic; Androgen; Endocrine; Hormone; Steroids ID RAT VENTRAL PROSTATE; SKELETAL-MUSCLE; MESSENGER-RNA; OLDER MEN; EXPRESSION; HYPERTROPHY; OVERLOAD; BINDING; AUTOREGULATION; STRENGTH AB The purpose of this study was to determine the influence of endogenous circulating testosterone (T) on muscle androgen receptor(AR) responses to acute resistance exercise (RE). Six healthy men (26 +/- 4 years; 176 +/- 5 cm; 75.8 +/- 11.4 kg) performed a knee extension exercise protocol on two occasions separated by 1-3 weeks. Rest preceded one trial (i.e., control [CON] trial) and a high-volume upper-body RE protocol designed to increase circulatingT preceded the other trial (i.e., high T [HT] trial). Serial blood samples were obtained throughout each trial to determine circulating T concentrations. Biopsies of the vastus lateralis were obtained pre-RE (REST), 10-min post-RE (+10), and 180-min post-RE (+180) to determine muscle AR content. Circulating T concentrations remained stable during CON. Alternately, HT significantly (p <= 0.05) increased T concentrations above resting values (+16%). Testosterone area-under-the-time curve during HT exceeded CON by 14%. AR content remained stable from REST to +10 in both trials. Compared to the corresponding +10 value, muscle AR content at +180 tended to decrease during CON (-33%; p = 0.10) but remained stable during HT (+40%; p = 0.17). Muscle AR content at +180 during the HT trial exceeded the corresponding CON value. In conclusion, acute elevations in circulating T potentiated muscle AR content following RE. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Kraemer, William J.] Univ Connecticut, Human Performance Lab, Dept Kinesiol, Storrs, CT 06269 USA. [Ratamess, Nicholas A.] Kean Coll New Jersey, Dept Hlth & Exercise Sci, Ewing, NJ 08628 USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Hakkinen, Keijo] Univ Jyvaskyla, Dept Biol Phys Activ, SF-40100 Jyvaskyla, Finland. [Hakkinen, Keijo] Univ Jyvaskyla, Neuromuscular Res Ctr, SF-40100 Jyvaskyla, Finland. RP Kraemer, WJ (reprint author), Univ Connecticut, Human Performance Lab, Dept Kinesiol, 2095 Hillside Rd,Unit 1110, Storrs, CT 06269 USA. EM William.Kraemer@uconn.edu FU National Strength and Conditioning Association; University of Connecticut FX This work was supported, in part, by graduate student research grants awarded by the National Strength and Conditioning Association and the University of Connecticut. The authors would like to thank Dr. Disa Hatfield, Dr. Mick Joseph, Jen-Yu Ho, Maren Fragala, and Elaine Lee for their assistance with data collection. NR 28 TC 33 Z9 34 U1 2 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-0760 J9 J STEROID BIOCHEM JI J. Steroid Biochem. Mol. Biol. PD APR PY 2009 VL 114 IS 3-5 BP 195 EP 199 DI 10.1016/j.jsbmb.2009.02.005 PG 5 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 437QX UT WOS:000265503100011 PM 19429451 ER PT J AU Bilchik, AJ Stojadinovic, A Wainberg, Z Hecht, JR AF Bilchik, Anton J. Stojadinovic, Alexander Wainberg, Zev Hecht, J. Randolph TI Targeted Lymph Node Evaluation in Colorectal Cancer: A Decade Of Progress! SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Editorial Material ID POLYMERASE-CHAIN-REACTION; RESECTABLE COLON-CANCER; SENTINEL NODE; MULTICENTER TRIAL; POOLED ANALYSIS; STAGE-II; MICROMETASTASES; CARCINOMA C1 [Bilchik, Anton J.; Wainberg, Zev; Hecht, J. Randolph] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. [Bilchik, Anton J.; Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. RP Bilchik, AJ (reprint author), Calif Oncol Res Inst, 2336 Santa Monica Blvd,Suite 206, Santa Monica, CA 90404 USA. EM abilchik@aol.com FU NCI NIH HHS [2 R01 CA090848-05A2, R01 CA090848, R01 CA090848-05A2] NR 24 TC 1 Z9 1 U1 0 U2 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD APR 1 PY 2009 VL 99 IS 5 BP 273 EP 274 DI 10.1002/jso.21231 PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 429FP UT WOS:000264906600002 PM 19170087 ER PT J AU Liu, K Ayers, P Howard, H Anderson, A AF Liu, Kun Ayers, Paul Howard, Heidi Anderson, Alan TI Influence of turning radius on wheeled military vehicle induced rut formation SO JOURNAL OF TERRAMECHANICS LA English DT Article ID DISTURBANCE AB A rut is it depression or groove formed into the ground by the travel of wheels and tracks. Ruts can cause severe influences on soil and vegetation, and reduce vehicle mobility. In this paper, rut depth and rut width were used as the main indicators to quantify it rut. A new indicator, rut index, was proposed, combining rut depth and rut width. A Light Armored Vehicle (LAV) and a High Mobility Multi-purpose Wheeled Vehicle (HMMWV) were used for testing the influence of turning radius oil rut depth, rut width and rut index. The LAV and the HMMWV were operated in spiral patterns at different speeds. Differential GPS data for the vehicles were collected every second during the spiral. Rut measurements were manually taken every 4-7 in along each of the spiral tracks. The results of field tests indicate that rut depth, rut width and rut index increase with the decrease of turning radius, especially when turning radius is less than 20 m. Velocity influences rut formation for the LAV but not HMMWV. (C) 2009 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Liu, Kun; Ayers, Paul] Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA. [Howard, Heidi; Anderson, Alan] USA, Construct Engn Res Lab, Erdc, Champaign, IL 61822 USA. RP Ayers, P (reprint author), Univ Tennessee, Dept Biosyst Engn & Soil Sci, 2506 EJ Chapman Dr, Knoxville, TN 37996 USA. EM ayers@utk.edu NR 13 TC 6 Z9 7 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD APR PY 2009 VL 46 IS 2 BP 49 EP 55 DI 10.1016/j.jterra.2009.02.004 PG 7 WC Engineering, Environmental SC Engineering GA 450RS UT WOS:000266419100002 ER PT J AU Rushing, TS Tingle, JS AF Rushing, Todd S. Tingle, Jeb S. TI Full-scale evaluation of mat surfacings for roads over sand subgrades SO JOURNAL OF TERRAMECHANICS LA English DT Article AB Nine commercial mat systems were evaluated for use as expedient road surfacings over sand subgrades for beach crossing scenarios. Four were rolled mats and five were panel-type systems. A full-scale test section of each mat system wits installed over a sand subgrade and trafficked with a fully loaded military truck. Mat deformation and damage were systematically Surveyed at a series of traffic level intervals up to 2000 truck passes. The performance data were analyzed and presented graphically, and the mats were compared according to their abilities to sustain the traffic. The mat systems were further evaluated on the bases of rate of deployment, logistical footprint (unit weight and volume), and cost. Published by Elsevier Ltd on behalf of ISTVS. C1 [Rushing, Todd S.; Tingle, Jeb S.] USA, GSL, Erdc, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Rushing, TS (reprint author), USA, GSL, Erdc, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM todd.s.rushing@erdc.usace.army.mil NR 7 TC 1 Z9 3 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD APR PY 2009 VL 46 IS 2 BP 57 EP 63 DI 10.1016/j.jterra.2009.02.002 PG 7 WC Engineering, Environmental SC Engineering GA 450RS UT WOS:000266419100003 ER PT J AU Sutin, A Libbey, B Fillinger, L Sarvazyan, A AF Sutin, Alexander Libbey, Brad Fillinger, Laurent Sarvazyan, Armen TI Wideband nonlinear time reversal seismo-acoustic method for landmine detection SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ELASTIC SURFACE-WAVES; DETECTION SYSTEM; BURIED OBJECTS; MINE DETECTION; SIMULATION; MEDIA AB Acoustic and seismic waves provide a method to localize compliant mines by vibrating the top plate and a thin soil layer above the mine. This vibration is mostly linear, but also includes a small nonlinear deviation. The main goal of this paper is to introduce a method of processing that uses phase-inversion to observe nonlinear effects in a wide frequency band. The method extracts a nonlinear part of surface velocity from two similar broadcast signals of opposite sign by summing and canceling the linear components and. leaving the nonlinear components. This phase-inversion method is combined with time reversal focusing to provide increased seismic vibration and enhance the nonlinear effect. The experiments used six loudspeakers in a wood box placed over sand in which inert landmines were buried. The nonlinear surface velocity of the sand with a. mine compared to the sand without a mine was greater as compared to a linear technique. (C) 2009 Acoustical Society of America. [DOI: 10.1121/1.3083223] C1 [Sutin, Alexander; Fillinger, Laurent] Stevens Inst Technol, Hoboken, NJ 07030 USA. [Sutin, Alexander; Sarvazyan, Armen] ARTANN Labs Inc, Trenton, NJ 08618 USA. [Libbey, Brad] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Sutin, A (reprint author), Stevens Inst Technol, Hoboken, NJ 07030 USA. FU U.S. Army, RDECOM [W909MY-05-C-0007] FX The U.S. Army, RDECOM, CERDEC Night Vision and Electronic Sensors Directorate supported this work under Contract No. W909MY-05-C-0007. The authors would like to acknowledge Stevens Institute of Technology for providing the six-channel speaker enclosure. NR 29 TC 11 Z9 11 U1 0 U2 3 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD APR PY 2009 VL 125 IS 4 BP 1906 EP 1910 DI 10.1121/1.3083223 PG 5 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 442JR UT WOS:000265838000019 PM 19354365 ER PT J AU Floros, MW Johnson, W AF Floros, Matthew W. Johnson, Wayne TI Performance Analysis of the Slowed-Rotor Compound Helicopter Configuration SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB The calculated performance of a slowed-rotor compound aircraft, particularly at high flight speeds, is examined. Correlation of calculated and measured performance is presented for a NASA Langley high advance ratio test to establish the capability to model rotors in such flight conditions. The predicted performance of an isolated rotor and a wing and rotor combination are examined in detail. Three tip speeds and a range of collective pitch settings are investigated. A tip speed of 230 ft/s and zero collective pitch are found to be the best condition to minimize rotor drag over a wide speed range. Detailed rotor and wing performance is examined for both sea level and cruise altitude conditions. Rotor and wing power are found to be primarily from profile drag, except at low speed where the wing is near stall. Increased altitude offloads lift from the rotor to the wing, reducing total power required. C1 [Floros, Matthew W.] USA, Res Lab, Hampton, VA USA. [Johnson, Wayne] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. RP Floros, MW (reprint author), NASA, Langley Res Ctr, MS 266, Hampton, VA 23681 USA. EM matt.floros@us.army.mil NR 14 TC 9 Z9 9 U1 1 U2 4 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 2009 VL 54 IS 2 AR 022002 DI 10.4050/JAHS.54.022002 PG 12 WC Engineering, Aerospace SC Engineering GA V16MQ UT WOS:000207874100002 ER PT J AU Vertrees, A Fox, CJ Quan, RW Cox, MW Adams, ED Gillespie, DL AF Vertrees, Amy Fox, Charles J. Quan, Reagan W. Cox, Mitchell W. Adams, Eric D. Gillespie, David L. TI The Use of Prosthetic Grafts in Complex Military Vascular Trauma: A Limb Salvage Strategy for Patients With Severely Limited Autologous Conduit SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Vascular trauma; Damage control; Prosthetic grafts; PTFE; Polytetrafluoroethylene; Extremity injury; War injury ID CONTAMINATED WOUNDS; PTFE GRAFTS; INJURIES; POLYTETRAFLUOROETHYLENE; MANAGEMENT; VEIN; RECONSTRUCTION; EXPERIENCE; ADHERENCE; VESSELS AB Background: The use of prosthetic grafts for reconstruction of military vascular trauma has been consistently discouraged. In the current conflict, however, the signature wound involves multiple extremities with significant loss of soft tissue and potential autogenous venous conduits. We reviewed the experience with the use of prosthetic grafts for the treatment of vascular injuries sustained during recent conflicts in Iraq and Afghanistan. Methods: Trauma registry records with combat-related vascular injuries repaired using prosthetic grafts were retrospectively reviewed from March 2003 to April 2006. Data collected included age, gender, mechanism of injury, vessel injured, conduit, graft patency, complications, including amputation and eventual outcome of repair. Results: Prosthetic grafts were placed in 14 of 95 (15%) patients undergoing extremity bypass for vascular injuries. Patients were men with an average age of 25 years (range, 19-39 years). All prosthetic grafts in this series were made of polytetrafluoroethylene. Mechanism of injury included blast (n = 6), gunshot wounds (n = 6), and blunt trauma (n = 2), resulting in prosthetic repair of injuries to the superficial femoral (n = 8), brachial (n = 3), common carotid (n = 1), subclavian (n = 1), and axillary (n = 1) arteries. Mean evacuation time from injury to stateside arrival was 7 days (range, 3-9 days). Twelve grafts were placed initially at the time of injury, and two after vein graft blow out with secondary hemorrhage. The mean follow-up period was 427 days (range, 49-1,285 days). Seventy-nine percent of prosthetic grafts stayed patent in the short term, allowing patient stabilization, transport to a stateside facility, and elective revascularization with the remaining autologous vein graft. Three prosthetic grafts were replaced urgently for thrombosis. The remaining seven grafts were replaced electively for severe stenosis (3) or exposure (4) with presumed infection. There were no prosthetic graft blow outs or deaths in this series. No patients required amputation because of prosthetic graft failure. Three (21%) patients went on to have elective lower extremity amputation, despite patent grafts for nonsalvagable limbs. Conclusions: When managing patients with multiple extremity trauma and limited noninjured autogenous venous conduits, emergent use of prosthetic grafts may provide an effective limb salvage strategy. Despite being placed in multisystem trauma patients with large contaminated soft tissue wounds, emergent revascularization with polytetrafluoroethylene allowed patient stabilization, transport to a higher echelon of care, and elective revascularization with remaining limited autologous vein. C1 [Gillespie, David L.] Univ Rochester, Sch Med & Dent, Div Vasc Surg, Rochester, NY 14627 USA. [Vertrees, Amy; Fox, Charles J.; Quan, Reagan W.; Cox, Mitchell W.; Adams, Eric D.] Walter Reed Army Med Ctr, Vasc Surg Serv, Washington, DC 20307 USA. [Fox, Charles J.; Quan, Reagan W.; Adams, Eric D.; Gillespie, David L.] Uniformed Univ Hlth Sci, Div Vasc Surg, Bethesda, MD USA. RP Gillespie, DL (reprint author), Univ Rochester, Sch Med & Dent, Div Vasc Surg, Rochester, NY 14627 USA. EM david_gillespie@urmc.rochester.edu OI Gillespie, David/0000-0002-4378-9465 NR 15 TC 14 Z9 14 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 EI 1529-8809 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP 980 EP 983 DI 10.1097/TA.0b013e31819c59ac PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431KI UT WOS:000265059800004 PM 19359902 ER PT J AU Wade, CE Dubick, MA Blackbourne, LH Holcomb, JB AF Wade, Charles E. Dubick, Michael A. Blackbourne, Lorne H. Holcomb, John B. TI It is Time to Assess the Utility of Thrombelastography in the Administration of Blood Products to the Patient With Traumatic Injuries SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material ID LIFE-THREATENING COAGULOPATHY; MASSIVELY BLEEDING PATIENTS; FEMALE-PATIENTS; TRANSFUSION; HYPERCOAGULABILITY; HYPOTHERMIA C1 [Wade, Charles E.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Dept Surg, Houston, TX USA. RP Wade, CE (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Ave, Ft Sam Houston, TX 78234 USA. EM charles.wade@amedd.army.mil NR 14 TC 9 Z9 13 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP 1258 EP 1258 DI 10.1097/TA.0b013e31819adb04 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431KI UT WOS:000265059800058 PM 19359946 ER PT J AU Beekley, AC Martin, MJ Spinella, PC Telian, SP Holcomb, JB AF Beekley, Alec C. Martin, Matthew J. Spinella, Philip C. Telian, Simon P. Holcomb, John B. TI Predicting Resource Needs for Multiple and Mass Casualty Events in Combat: Lessons Learned From Combat Support Hospital Experience in Operation Iraqi Freedom SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Military surgery; Mass casualties; Multiple casualties; Damage control resuscitation; Combat; Trauma; War ID DAMAGE CONTROL RESUSCITATION; BLOOD-CELL TRANSFUSIONS; FRESH WHOLE-BLOOD; TRAUMA CARE; HEMORRHAGE CONTROL; MANAGEMENT; INCIDENTS; MORTALITY; MILITARY; INJURIES AB Objective: We hypothesized that the number of evacuated casualties from a combat-related multiple casualty event provides an initial baseline estimate of the number of blood products required for the event. Methods: A retrospective review of combat support hospitals' experiences in Operation Iraqi Freedom was performed, (from December 2003 to December 2004). Identified multiple casualty events were analyzed for mechanisms of injury, total number of patients arriving to the combat support hospitals, average injury severity score, operative interventions, blood product requirements, and short-term outcomes (24-hour mortality). Selected events in which the Packed cells per Patient Index (PPI) was greater than a SD away from the mean were analyzed further regarding the casualties' injuries, the triage decisions during the event, operations, and patient outcomes. Results: Of 367 days and 3,533 casualties, multiple or mass casualty events were identified on 26 days, accounting for 18% of casualties treated for the year. Twenty-two percent of all evacuated casualties from a multiple casualty event required transfusion and 4.2% required massive transfusion. Patients injured by discrete explosion-related events had an increased incidence of massive transfusion compared with patients injured from fire-rights, 9.6% versus 4%, respectively, (p < 0.05). The average number of RBC units (packed red blood cells units + fresh whole blood units) per patient (PPI) for these events was 1.4 (+/-0.8). Review of casualty events where the PPI was higher revealed either potential triage or treatment errors. Conclusions: Baseline blood product requirements for a multiple or mass casualty combat-related event can be estimated from the number of evacuated casualties involved. C1 [Beekley, Alec C.] Madigan Army Med Ctr, Dept Gen Surg, Tacoma, WA 98431 USA. [Spinella, Philip C.] Connecticut Childrens Med Ctr, Hartford, CT USA. [Telian, Simon P.] USA, Med Dept Activ, Heidelberg, Germany. [Holcomb, John B.] USA, Inst Surg Res, San Antonio, TX USA. RP Beekley, AC (reprint author), Madigan Army Med Ctr, Dept Gen Surg, 9040 Fitzsimmons Ave, Tacoma, WA 98431 USA. EM alec.beekley@amedd.army.mil RI Martin, Matthew/B-2676-2014 OI Martin, Matthew/0000-0002-9169-9069 NR 34 TC 15 Z9 16 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S129 EP S137 DI 10.1097/TA.0b013e31819d85e7 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100020 PM 19359956 ER PT J AU Bell, RS Vo, AH Neal, CJ Tigno, J Roberts, R Mossop, C Dunne, JR Armonda, RA AF Bell, Randy S. Vo, Alexander H. Neal, Christopher J. Tigno, June Roberts, Ryan Mossop, Corey Dunne, James R. Armonda, Rocco A. TI Military Traumatic Brain and Spinal Column Injury: A 5-Year Study of the Impact Blast and Other Military Grade Weaponry on the Central Nervous System SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Traumatic brain injury; Military; Spinal column injury ID MISSILE HEAD WOUNDS; PENETRATING CRANIOCEREBRAL INJURIES; COMA-DATA-BANK; GUNSHOT WOUNDS; PULMONARY-EMBOLISM; ANEURYSMS; MANAGEMENT; MORTALITY; SECONDARY; WAR AB Background: During the past 5 years of Operation Iraqi Freedom (OIF), a significant majority of the severe closed and penetrating head trauma has presented for definitive care at the National Naval Medical Center (NNMC) in Bethesda, MD, and at the Walter Reed Army Medical Center (WRAMC) in Washington, DC. The purpose of this article is to review our experience with this population of patients. Materials: A retrospective review of all inpatient admissions from OIF was performed during a 5-year period (April 2003 to April 2008). Criteria for inclusion in this study included either a closed or penetrating head trauma suffered during combat operations in Iraq who subsequently received a neurosurgical evaluation at NNMC or WRAMC. Exclusion criteria included all patients for whom primary demographic data could not be verified. Primary outcome data included the type and mechanism of injury, Glasgow coma scale (GCS) and injury severity score at admission, and Glasgow outcome scale (GOS) at discharge, 6 months, and 1 to 2 years. Results: Five hundred thirteen consultations were performed by the neurosurgery service on the aforementioned population. Four hundred eight patients met the inclusion criteria for this study (401:7, male: female; 228 penetrating brain injury, 139 closed head injury, 41 not specified). Explosive blast injury (229 patients; 56%) constituted the predominant mechanism of injury. The rates of pulmonary embolism (7%), cerebrospinal fluid leak (8.6%), meningitis (9.1%), spinal cord or column injury (9.8%), and cerebrovascular injury (27%) were characterized. Cerebrospinal fluid leak, vasospasm, penetrating head injury, and lower presenting GCS were statistically associated with longer intensive care unit stays and higher presenting injury severity scores (p < 0.05). While presenting GCS 3-5 correlated with worsened short-term and long-term GOS scores (p < 0.001), almost half of these patients achieved GOS >= 3 at 1- to 2-year follow-up. Total mortality after reaching NNMC/WRAMC was 4.4%. Conclusions. OIF has resulted in the highest concentration of severe closed and penetrating head trauma to return to NNMC and WRAMC since the Vietnam Conflict. Management scenarios were complex, incorporating principles designed to maximize outcomes in all body systems. Meaningful survival can potentially be achieved in a subset of patients with presenting GCS <= 5. C1 [Bell, Randy S.; Neal, Christopher J.; Armonda, Rocco A.] Natl Naval Med Ctr, Dept Neurosurg, Bethesda, MD 20889 USA. [Dunne, James R.; Armonda, Rocco A.] Natl Naval Med Ctr, Dept Trauma Crit Care, Bethesda, MD 20889 USA. [Vo, Alexander H.] Univ Texas Galveston, Med Branch, Galveston, TX 77550 USA. [Bell, Randy S.; Neal, Christopher J.; Tigno, June; Roberts, Ryan; Mossop, Corey; Armonda, Rocco A.] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. RP Bell, RS (reprint author), Natl Naval Med Ctr, Dept Neurosurg, Bethesda, MD 20889 USA. EM randy.bell@med.navy.mil NR 40 TC 86 Z9 88 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S104 EP S111 DI 10.1097/TA.0b013e31819d88c8 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100017 PM 19359953 ER PT J AU Blackbourne, LH Pruitt, B AF Blackbourne, Lorne H. Pruitt, Basil, Jr. TI The Warrior's Combat Surgeon: COL (ret.) John B. Holcomb, MD, FACS-US Army 1985-2008 SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material C1 [Blackbourne, Lorne H.; Pruitt, Basil, Jr.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM lorne.blackbourne@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S29 EP S30 DI 10.1097/TA.0b013e31819cdf99 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100002 PM 19359967 ER PT J AU Blackbourne, LH AF Blackbourne, Lorne H. TI The Next Generation of Combat Casualty Care SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material C1 [Blackbourne, Lorne H.] USA, Inst Surg Res, San Antonio, TX USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM lorne.h.blackbourne@us.army.mil NR 0 TC 7 Z9 9 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S27 EP S28 DI 10.1097/TA.0b013e31819cdf83 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100001 PM 19359966 ER PT J AU Dunne, JR Hawksworth, JS Stojadinovic, A Gage, F Tadaki, DK Perdue, PW Forsberg, J Davis, T Denobile, JW Brown, TS Elster, EA AF Dunne, James R. Hawksworth, Jason S. Stojadinovic, Alexander Gage, Fred Tadaki, Doug K. Perdue, Philip W. Forsberg, Jonathan Davis, Tom Denobile, John W. Brown, Trevor S. Elster, Eric A. TI Perioperative Blood Transfusion in Combat Casualties: A Pilot Study SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID OPERATION-IRAQI-FREEDOM; DAMAGE CONTROL RESUSCITATION; MULTIPLE ORGAN FAILURE; ENDURING-FREEDOM; EARLY COAGULOPATHY; EXTREMITY WOUNDS; CARDIAC-SURGERY; MARINE-CORPS; RISK; TRAUMA AB Background: In recent studies, blood transfusion has been shown to increase the rate of wound heating disturbances in orthopedic patients. Furthermore, our group has determined a correlation between delayed wound heating and elevations in inflammatory mediators in combat casualties. Therefore, we sought to determine the effect of blood transfusion on wound healing and inflammatory mediator release in combat casualties. Methods: Prospective data were collected on 20 severely injured combat casualties sustaining extremity wounds. Patients were admitted to the National Naval Medical Center during a 13-month period from January 2007 to January 2008. Data variables included age, gender, Glasgow coma score (GCS), mechanism of injury, and transfusion history. Injury severity was assessed using the Injury Severity Score (ISS). Serum was collected initially and before each surgical wound debridement and analyzed using a panel of 21 cytokines and chemokines. The association between blood transfusion and wound healing, incidence of perioperative infection, intensive care unit (ICU) admission rate, and ICU and hospital length of stay was assessed. Differences were considered significant when p < 0.05. Results: The study cohort had a mean age of 22 +/- 1, a mean ISS of 15.8 +/- 2.6, and a mean GCS 13.9 +/- 0.6; all were men and suffered penetrating injuries (90% improvised explosive device [IED] and 10% gunshot wound [GSW]). The cohort was divided into two groups. Patients receiving <= 4 units of blood initially (group 1, n = 11) were compared with patients who received >4 units of blood initially (group 2, n = 9). There was no significant difference in age, ISS, GCS, or mortality between the two groups. How-ever, group 2 patients had significant impairment in wound healing rate (54% vs. 9%, p < 0.05), higher ICU admission rate (78% vs. 9%, p < 0.01), perioperative infection rate (89% vs. 27%, p < 0.01), and a longer hospital length of stay (49.9 +/- 12.8 vs. 23.8 +/- 2.9, p < 0.05) compared with group 1 patients. In addition, there was a significant correlation between the initial mean serum cytokine/chemokine level of interleukin (IL)-10, IL-8, interferon inducible protein (IP)-10, IL-6, and IL-12p40 and the number of units of blood transfused (p < 0.05). Conclusion: Allogeneic blood transfusions in combat casualties were associated with impaired wound heating, increased perioperative infection rate, and resource utilization. In addition, the extent of blood transfusion was associated with significant differences in inflammatory chemokine and cytokine release. C1 [Dunne, James R.; Perdue, Philip W.; Denobile, John W.; Elster, Eric A.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD 20889 USA. [Hawksworth, Jason S.; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Stojadinovic, Alexander; Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Gage, Fred; Tadaki, Doug K.; Davis, Tom; Brown, Trevor S.; Elster, Eric A.] USN, Med Res Ctr, Regenerat Med Dept, Silver Spring, MD USA. [Forsberg, Jonathan] Natl Naval Med Ctr, Dept Orthoped, Bethesda, MD 20889 USA. RP Dunne, JR (reprint author), Natl Naval Med Ctr, Dept Surg, Bethesda, MD 20889 USA. EM james.dunne@med.navy.mil FU US Navy Bureau of Medicine and Surgery; Medical Department Program [PE 060477 IN] FX Supported (in part) by the US Navy Bureau of Medicine and Surgery and the Medical Department Program (PE 060477 IN). NR 42 TC 9 Z9 9 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S150 EP S156 DI 10.1097/TA.0b013e31819d9561 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100023 PM 19359959 ER PT J AU Eastridge, BJ Stansbury, LG Stinger, H Blackbourne, L Holcomb, JB AF Eastridge, Brian J. Stansbury, Lynn G. Stinger, Harry Blackbourne, Lorne Holcomb, John B. TI Forward Surgical Teams Provide Comparable Outcomes to Combat Support Hospitals During Support and Stabilization Operations on the Battlefield SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Injury; Trauma; Forward Surgical Team; Hospital; War; Combat; Battlefield ID US-MARINE-CORPS; TRAUMA SYSTEM; IRAQI-FREEDOM; ENDURING FREEDOM; EXPERIENCE; STATES; AFGHANISTAN; EVOLUTION; SURGERY; ARMY AB Background: Forward Surgical Team (FST) provide forward deployed surgical care within the battle space. The next level of care in theater, the Combat Support Hospitals (CSH), are distinguished from the FST by advanced resource capabilities including more complex diagnostic imaging, laboratory support with blood banking, and intensive care units. This study was intended to assess the effect of FST capability on the outcome of seriously injured casualties in comparison to the CSH. Methods. We reviewed all casualty records in the Joint Theater Trauma Registry database from April 2004 to April 2006. The study cohort included all US military battle casualties who were admitted to either a FST or a CSH and were not returned to duty within 72 hours. Data were tabulated and assessed for basic demographics, mechanism of injury, injury severity score, ventilator and critical care days, and mortality. Statistical inferences were made using Chi square and Student's t tests. Results: As of April 2006, the above information was available in the Joint Theater Trauma Registry on 2,617 US military battle casualties who survived to reach care at a FST and/or CSH. Of this population, 77 subsequently died of wounds and 2,540 survived. We found no significant difference in died of wounds rates between the sample populations or rates of ventilator or critical care days between the two groups, nor did controlling for injury severity score alter this picture. The most significant predictor of mortality in both these groups was head injury. Conclusions: The disparity between the availability of the highest level of injury care and the ability to care for injury as soon as possible is an issue of central importance to both the civilian and military trauma care communities. Our analysis demonstrates that despite the operational and logistic challenges that burden the FST, this level of surgical care confers equivalent battlefield injury outcome results compared with the CSH. C1 [Eastridge, Brian J.] USA, Inst Surg Res, MCMR SRJ, Ft Sam Houston, TX 78234 USA. RP Eastridge, BJ (reprint author), USA, Inst Surg Res, MCMR SRJ, 3400 Rawley E Chamber Ave, Ft Sam Houston, TX 78234 USA. EM brian.eastridge@amedd.army.mil NR 20 TC 18 Z9 19 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S48 EP S50 DI 10.1097/TA.0b013e31819ce315 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100006 PM 19359970 ER PT J AU Fox, CJ Mehta, SG Cox, ED Kragh, JF Salinas, J Holcomb, JB AF Fox, Charles J. Mehta, Sumeru G. Cox, E. Darrin Kragh, John F., Jr. Salinas, Jose Holcomb, John B. TI Effect of Recombinant Factor VIIa as an Adjunctive Therapy in Damage Control for Wartime Vascular Injuries: A Case Control Study SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Advanced Technology Applications in Combat Casualty Care Conference (ATACCC) CY AUG 11-13, 2008 CL St Pete Beach, FL DE Vascular trauma; Damage control; Resuscitation; Coagulopathy; Factor VIIa; Wartime; Military; Combat ID ACTIVATED FACTOR-VII; REQUIRING MASSIVE TRANSFUSION; CONTROL RESUSCITATION; TRAUMA PATIENTS; ACQUIRED COAGULOPATHY; BLEEDING CONTROL; BLOOD-PRODUCTS; PATIENT; MORTALITY; SURGERY AB Objectives: Military casualties with vascular injuries often present with severe acidosis and coagulopathy that can negatively influence limb salvage decisions. We previously reported the value of a damage control resuscitation (DCR) strategy that can correct physiologic shock during simultaneous vascular reconstruction. The effect of recombinant factor VIIa (rFVIIa) on the repair of injured vessels and vascular grafts when used as an adjunctive therapy during DCR is unclear in the setting of wartime vascular injuries. The primary aim of this study was to assess the effect of rFVIIa use during DCR for vascular trauma and the impact on vessel repair. Methods: A retrospective two cohort case control study was performed using the Joint Theater Trauma Registry to identify patients with major vascular injury and DCR. Group 1 (n = 12) had DCR and repair of the injured vessels. Group 2 (n = 41) included early rFVIIa as an adjunctive therapy with DCR to control bleeding and perform simultaneous vascular reconstruction. Results: Age, injury severity score, presenting physiology, and operative time were similar between groups. Postoperative data show that early physiologic recovery from acidosis, coagulopathy, and anemia was associated with rFVIIa and DCR. Extremity graft failures in groups I and 2 (follow-up range, 10-26 months) were either from early thrombosis (I vs. 5 p = 1), graft dehiscence (1 vs. 2 p = 0.55), or infection (1 vs. 1 p = 0.41) and were the result of inadequate soft tissue coverage or technical factors that eventually resulted in eight (15%) amputations. All cause mortality (group 1: 0% vs. group 2: 7.3%, p = 1) and amputation rates (group 1: 25% vs. groups 2: 12.2%, p = 0.36) were similar between the two groups. Conclusions: DCR using rFVIIa is effective for controlling hemorrhage and reversing coagulopathy for severe vascular injuries. Early graft failures seem unrelated to rFVIIa use in the setting of wartime vascular injuries. No differences in amputation rate or mortality were seen. Although rFVIIa may be a useful damage control adjunct during vessel repair, the overall impact of this strategy on long-term outcomes such as mortality and limb salvage remains to be determined. C1 [Fox, Charles J.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Fox, Charles J.] Uniformed Univ Hlth Sci, Div Vasc Surg, Bethesda, MD USA. [Mehta, Sumeru G.] Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX USA. [Cox, E. Darrin] William Beaumont Army Med Ctr, Dept Surg, El Paso, TX 79920 USA. [Kragh, John F., Jr.; Salinas, Jose; Holcomb, John B.] USA, Inst Surg Res, San Antonio, TX USA. RP Fox, CJ (reprint author), Walter Reed Army Med Ctr, Dept Surg, Bldg 2,Ward 64,6900 Georgia Ave NW, Washington, DC 20307 USA. EM Charles.Fox@us.army.mil NR 30 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S112 EP S119 DI 10.1097/TA.0b013e31819ce240 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100018 PM 19359954 ER PT J AU Gaylord, KM Holcomb, JB Zolezzi, ME AF Gaylord, Kathryn M. Holcomb, John B. Zolezzi, Maria E. TI A Comparison of Posttraumatic Stress Disorder Between Combat Casualties and Civilians Treated at a Military Burn Center SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID PSYCHOLOGICAL HEALTH; INJURY; PTSD; PREDICTORS; CHECKLIST; SYMPTOMS; DISTRESS; IRAQ; CARE AB Background: Posttraumatic stress disorder (PTSD) has been identified in 12% to 20% of noninjured veterans and in 32% of combat casualties. Eight percent of the US general population experience PTSD symptoms, whereas 25.5% of civilians with major burns have PTSD. Known predictors of physical outcomes of patients with burn are age, total body surface area (TBSA) burned, and Injury Severity Score (ISS). The United States Army Institute of Surgical Research Burn Center provides burn care for combat casualties and civilians. We hypothesized that we would rind no difference in PTSD incidence between these two populations and that age, TBSA, and ISS are associated with PTSD. Method: We retrospectively examined the clinical records of 1,792 patients admitted between October 2003 and May 2008. Records were stratified by PTSD, age, TBSA, and ISS. PTSD scores were compared. Descriptive analyses were used. Results: Four hundred ninety-nine patients (372 military [74.5%]; 127 civilians [25.5%]) were assessed for PTSD using PTSD checklist military and civilian versions. PTSD was defined as 2:44 on the PTSD checklist instruments. We found no significant difference in PTSD between combat casualties and civilians (25% vs. 17.32%, p = 0.761). TBSA and ISS were significantly associated with PTSD; however, no association between age and PTSD was found. Conclusion: The incidence of PTSD is not significantly different in burned combat casualties and civilians treated at the same burn unit. These findings suggest that PTSD is related to the burn trauma and not to the circumstances surrounding the injury. C1 [Gaylord, Kathryn M.; Holcomb, John B.; Zolezzi, Maria E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Gaylord, KM (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM Kathryn.gaylord@amedd.army.mil NR 30 TC 8 Z9 8 U1 5 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S191 EP S195 DI 10.1097/TA.0b013e31819d9c21 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100031 PM 19359965 ER PT J AU Hospenthal, DR Crouch, HK AF Hospenthal, Duane R. Crouch, Helen K. TI Infection Control Challenges in Deployed US Military Treatment Facilities SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Infection control; Infection; Military; Combat; Trauma ID COMBAT-RELATED INJURIES; ACINETOBACTER INFECTION; PREVENTION; MANAGEMENT; IMPACT; IRAQ; CASUALTIES; BAUMANNII; CARE AB Background: Personnel sustaining combat-related injuries in current overseas conflicts continue to have their care complicated by infections caused by multidrug-resistant organisms, including Acinetobacter, Klebsiella, and Pseudomonas. Although presumed to be due to multiple factors both within and outside of the combat theater, concern has been raised about the difficulties in establishing and maintaining standard infection control (IC) practices in deployed medical treatment facilities and in the evacuation of the injured back to the United States. Methods: Level M facilities (hospitals capable of holding patients >72 hours) in Iraq and Afghanistan and the evacuation system from Iraq to the continental US were reviewed by an expert IC-infectious disease team. Results: All reviewed facilities had established IC programs, but these were staffed by personnel with limited IC experience, often without perceived adequate time dedicated to perform their duties, and without uniform levels of command emphasis or support. Proper hand hygiene between patients was not always ideal. Isolation and cohorting of patients to decrease multidrug-resistant organism colonization and infection varied among facilities. Review of standard operating procedures found variability among institutions and in quality of these documents. Application of US national and theater-specific guidelines and of antimicrobial control measures also varied among facilities. Conclusions: Effective IC practices are often difficult to maintain in modern US hospitals. In the deployed setting, with ever-changing personnel in a less than optimal practice environment, IC is even more challenging. Standardization of practice with emphasis on the basics of IC practice (e.g., hand hygiene and isolation procedures) needs to be emplaced and maintained in the deployed setting. C1 [Hospenthal, Duane R.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Crouch, Helen K.] Brooke Army Med Ctr, Dept Med, Infect Control Serv, Ft Sam Houston, TX 78234 USA. [Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Bethesda, MD 20814 USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Duane.Hospenthal@amedd.army.mil NR 22 TC 19 Z9 19 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S120 EP S128 DI 10.1097/TA.0b013e31819cdd96 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100019 PM 19359955 ER PT J AU Lehmann, R Oh, J Killius, S Cornell, M Furay, E Martin, M AF Lehmann, Ryan Oh, John Killius, Sherry Cornell, Mark Furay, Elizabeth Martin, Matthew TI Interhospital Patient Transport by Rotary Wing Aircraft in a Combat Environment: Risks, Adverse Events, and Process Improvement SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Advanced Technology Applications in Combat Casualty Care Conference (ATACCC) CY AUG 11-13, 2008 CL St Pete Beach, FL ID EVACUATION AB Background. Helicopter transport of injured or ill patients in Operation Iraqi Freedom is a necessary but often high-risk endeavor. Our facility initiated a thorough process improvement and standardization initiative after several adverse outcomes. This report describes the results after this initiative, and evaluates the applicability of a civilian transport risk assessment tool to the combat environment. Methods. Review of all preflight, in-flight, and postflight records for helicopter medevac missions over a 7-month period. Adverse events included major equipment failures, clinical deterioration, or the need for urgent interventions on arrival. Transport risk scores (TRS) were calculated and assessed for correlation with adverse events. Results. There were 149 patient transports identified, 95 (64%) for trauma (mean Injury Severity Score, 21) and 54 (36%) for medical illness. Major surgical intervention before the flight was required in 66 (44%), massive transfusion in 29 (20%), and the majority were transported within 8 hours of surgery. In-flight mechanical ventilation was required in 53%, and 20% required vasopressors or cardioactive medications. Adverse events included equipment failures in 17% of flights, in-night clinical deterioration in 30%, and 9% required an urgent intervention on arrival. However, there were no deaths or significant flight-related morbidities identified. The mean TRS was significantly higher in patients with adverse events (9.1) versus those without (7.4, p < 0.05), but it showed only moderate discriminative ability (area under curve = 0.65, p < 0.01). Conclusions. Helicopter transport in a combat environment carries significant risk of adverse events because of the patient characteristics and inherent limitations of the transport platform. Strict attention to standardization, training, and process improvement is necessary to achieve optimal outcomes. The civilian TRS had lower discriminative ability in this military setting. C1 [Lehmann, Ryan; Martin, Matthew] Madigan Army Med Ctr, Dept Surg, Tacoma, WA USA. [Oh, John] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA. [Killius, Sherry; Cornell, Mark; Furay, Elizabeth] Joint Theater Trauma Registry, Baghdad, Iraq. RP Lehmann, R (reprint author), Madigan Army Med Ctr, Dept Surg, Tacoma, WA USA. EM rklehmann@gmail.com RI Martin, Matthew/B-2676-2014 OI Martin, Matthew/0000-0002-9169-9069 NR 12 TC 10 Z9 10 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S31 EP S34 DI 10.1097/TA.0b013e31819d9575 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100003 PM 19359968 ER PT J AU Martin, M Oh, J Currier, H Tai, N Beekley, A Eckert, M Holcomb, J AF Martin, Matthew Oh, John Currier, Heather Tai, Nigel Beekley, Alec Eckert, Matthew Holcomb, John TI An Analysis of In-Hospital Deaths at a Modern Combat Support Hospital SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Trauma; Death; War; Combat support hospital; Preventability ID OPERATION-IRAQI-FREEDOM; TEMPORARY VASCULAR SHUNTS; PREVENTABLE TRAUMA DEATHS; IMPACT MANAGEMENT ERRORS; 753 CONSECUTIVE DEATHS; DAMAGE CONTROL ADJUNCT; ENDURING-FREEDOM; QUALITY IMPROVEMENT; LIFE-SUPPORT; INJURY PREVENTION AB Background. Analysis of the epidemiology and attribution of in-hospital deaths is a critical component of learning and process improvement for any trauma center. We sought to perform a detailed analysis of in-hospital deaths at a combat support hospital. Methods: All patients with trauma who survived to admission and subsequently died before transfer or discharge during a I-year period were included. The timing, location, pathogenesis, and circumstances surrounding the death were recorded. Opportunities for improvement (01) of care were identified for analysis. Cases were presented to a panel of experts, and preventability of the deaths was scored on a continuous 10-point scale. Results. There were 151 deaths, with the predominant mechanisms of gunshot wounds (GSW) (47%) and blast injuries (42%). Most had severe injuries, with a mean Injury Severity Score of 38, pH of 7.09, and base deficit of 12. Predominant causes of death were head injury (45%) and hemorrhage (32%), and 78% died within I hour of admission. Most deaths occurred during the intensive care (35%) or resuscitation phases (31%), but the majority of deaths among nonexpectant patients occurred during the operative phase (38%). 01 were identified in 74 deaths (49%), and were found in 78% of nonexpectant deaths. Most improvement opportunities occurred during the resuscitation and transport phases. Most potential improvements were identified at the system level (54%) or individual provider level (42%). Preventability scoring showed excellent inter-rater reliability (r = 0.92, p < 0.001). Deaths with high preventability scores (mean >54) were primarily related to delays in hemorrhage control during the transportation (47%) or resuscitation (43%) phases, and attributed to the system (63%) and individual provider levels (70%). Conclusions: In-hospital combat trauma-related deaths at a modern Combat support hospital differ significantly from their civilian counterparts, and present multiple 01 of care and potential salvage. Delays in prehospital and in-hospital hemorrhage control are the primary contributors to potential preventability. C1 [Martin, Matthew; Beekley, Alec; Eckert, Matthew] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA. [Oh, John; Holcomb, John] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA. [Currier, Heather] Eisenhower Army Med Ctr, Div Cardiothorac Surg, Ft Gordon, GA USA. [Tai, Nigel] Barts & London NHS Trust, Dept Surg, London, England. RP Martin, M (reprint author), Madigan Army Med Ctr, Dept Surg, 9040-A Fitzsimmons Dr, Tacoma, WA 98431 USA. EM matthew.martin1@amedd.army.mil RI Martin, Matthew/B-2676-2014 OI Martin, Matthew/0000-0002-9169-9069 NR 70 TC 59 Z9 59 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S51 EP S60 DI 10.1097/TA.0b013e31819d86ad PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100007 PM 19359971 ER PT J AU McGhee, LL Maani, CV Garza, TH DeSocio, PA Gaylord, KM Black, IH AF McGhee, Laura L. Maani, Christopher V. Garza, Thomas H. DeSocio, Peter A. Gaylord, Kathryn M. Black, Ian H. TI The Relationship of Intravenous Midazolam and Posttraumatic Stress Disorder Development in Burned Soldiers SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID TRAUMA; MEMORY; SYMPTOMS; BENZODIAZEPINES; AFGHANISTAN; COMBAT; IRAQ AB Background: Midazolam, a short-acting benzodiazepine, is administered preoperatively and intraoperatively for amnesia and anxiolysis. Subsequently, patients often do not recall events which occurred while they were sedated. Recent studies have also reported retrograde facilitation after midazolam exposure. Posttraumatic stress disorder PTSD is based on memory of a traumatic event. Because of the concern that midazolam may enhance memory of the traumatic event in which soldiers were injured, we investigated the prevalence of PTSD in those burned soldiers who received perioperative midazolam and those who did not. We also investigated the intensity of the memories related to the traumatic event. Methods: After institutional review board approval, all charts of US soldiers who completed the PTSD Checklist-Military (PCL-M) screening tool (2004-2008) after admission to US Army Institute of Surgical Research were reviewed to determine the number of operations, the anesthetic regime, total body surface area (TBSA) burned, and Injury Severity Score (ISS). Results: The PCL-M was completed by 370 burned soldiers from Operation Iraqi Freedom/Operation Enduring Freedom. During surgery, 142 received midazolam, whereas 69 did not. The prevalence of PTSD was higher in soldiers receiving midazolam as compared with those who did not (29% vs. 25%) (p = 0.481). Both groups had similar injuries based on TBSA and ISS. Patients who received midazolam also had similar scores on PCL-M questions related to memory of the event. Conclusions: Rates of PTSD are not statistically different in combat casualties receiving midazolam during intraoperative procedures. Intraoperative midazolam is not associated with increased PTSD development or with increased intensity of memory of the traumatic event. Patients receiving midazolam had similar injuries (TBSA and ISS) and underwent a similar number of operations as those not receiving midazolam. C1 [McGhee, Laura L.; Maani, Christopher V.; Garza, Thomas H.; DeSocio, Peter A.] USA, Inst Surg Res, Battlefield Pain Control Project Area, Ft Sam Houston, TX 78234 USA. [Black, Ian H.] Brooke Army Med Ctr, Dept Anesthesiol, Ft Sam Houston, TX 78234 USA. RP McGhee, LL (reprint author), USA, Inst Surg Res, Battlefield Pain Control Area, 3400 Rawley E Chambers, Ft Sam Houston, TX 78234 USA. EM laura.mcghee@us.army.mil RI DeSocio, Peter/E-2970-2011 NR 27 TC 6 Z9 6 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S186 EP S190 DI 10.1097/TA.0b013e31819ce2f0 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100030 PM 19359964 ER PT J AU Mora, AG Ritenour, AE Wade, CE Holcomb, JB Blackbourne, LH Gaylord, KM AF Mora, Alejandra G. Ritenour, Amber E. Wade, Charles E. Holcomb, John B. Blackbourne, Lorne H. Gaylord, Kathryn M. TI Posttraumatic Stress Disorder in Combat Casualties With Burns Sustaining Primary Blast and Concussive Injuries SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Posttraumatic stress disorder; Primary blast injury; Mild traumatic brain injury; Burn injury; Explosion ID TRAUMATIC BRAIN-INJURY; OPERATION-ENDURING-FREEDOM; TYMPANIC-MEMBRANE PERFORATION; MENTAL-HEALTH PROBLEMS; IRAQI-FREEDOM; SERVICE MEMBERS; WAR; SYMPTOMS; VETERANS; CARE AB Background. There is a heightened focus on postexplosion functional outcomes in combat casualties. Previously, we reported a high prevalence of posttraumatic stress disorder (PTSD) (32%) and mild traumatic brain injury (mTBI) (41%) in patients with explosion-related burns. We hypothesized that the prevalence of PTSD in patients with burn was associated with primary blast injuries (PBIs) and mTBI. Methods. We reviewed the records of 333 patients admitted consecutively to the United States Army Institute of Surgical Research burn center for explosion-related injuries between March 2003 and March 2006. By using the Posttraumatic Checklist, Military Version (PCL-M), patients were evaluated for PTSD symptoms (PCL-M score >= 44). Loss of consciousness defined mTBI. Patient data were analyzed in groups based on PTSD (yes or no), mechanism of injury (improvised explosive device [IED] vs. other explosive), PBI (yes or no), and mTBI (yes or no). Results. Of 333 patients, 119 had PTSD assessments. Overall, PTSD was 22% (26 of 119). The prevalence of PTSD differed between mechanism of injury groups (p = 0.03). In the IED group (n = 105), 25% had PTSD symptoms and 18% had mTBI; patients injured by other explosive devices (n = 14) had no PTSD symptoms and one had mTBI (p = 0.04; p = 0.69, respectively). Also in the IED group, in patients with PBI, PTSD was 45% (9 of 20) compared with 20% (17 of 85) without PBI (odds ratio=3.27; 95% confidence interval, 1.17-9.16). More patients with PBI and mTBI (4 of 6; 67%) had PTSD symptoms compared with other patients (22 of 99; 22%) (odds ratio, 7.00; 95% confidence interval, 1.20-40.78). No other associations were found between PBI and mTBI. Conclusion: IED-wounded burn patients with PBI and mTBI have a greater prevalence of PTSD. Patients who did not have IED-related injuries did not have PTSD and only one had mTBI. C1 [Mora, Alejandra G.; Ritenour, Amber E.; Wade, Charles E.; Holcomb, John B.; Blackbourne, Lorne H.; Gaylord, Kathryn M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Gaylord, KM (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Rd, Ft Sam Houston, TX 78234 USA. EM Kathryn.Gaylord@amedd.army.mil NR 50 TC 21 Z9 22 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S178 EP S184 DI 10.1097/TA.0b013e31819ce2d6 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100028 PM 19359963 ER PT J AU Murray, CK Wilkins, K Molter, NC Yun, HC Dubick, MA Spott, MA Jenkins, D Eastridge, B Holcomb, JB Blackbourne, LH Hospenthal, DR AF Murray, Clinton K. Wilkins, Kenneth Molter, Nancy C. Yun, Heather C. Dubick, Michael A. Spott, Mary Ann Jenkins, Donald Eastridge, Brian Holcomb, John B. Blackbourne, Lorne H. Hospenthal, Duane R. TI Infections in Combat Casualties During Operations Iraqi and Enduring Freedom SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Combat; Infection; Iraq; Afghanistan ID INJURIES; EPIDEMIOLOGY; AFGHANISTAN; VIETNAM; WOUNDS; DEATH AB Background: Infections are a common acute and chronic complication of combat-related injuries; however, no systematic attempt to assess infections associated with US combat-related injuries occurring in Iraq and Afghanistan has been conducted. The Joint Theater Trauma Registry (JTTR) has been established to collect injury specific medical data from casualties in Iraq and Afghanistan. Methods: We reviewed the JTTR for the identification of infectious complications (IC) using International Classification of Diseases, 9th Revision (ICD-9) coding during two phases of the wars, before and after the end of the major ground operations in Iraq (19 March-May 31, 2003 and June 1, 2003-December 31, 2006). ICD-9 codes were combined into two categories; anatomic or clinical syndrome and pathogen. An IC was defined as the presence of ICD-9 codes that included both anatomic or clinical syndrome and a pathogen. Results: There were 425 patients evaluated in phase I and 684 in phase II with approximately one third having an IC. The most common anatomic or clinical syndrome codes were skin or wound followed by lung, and the most common pathogen code was gram-negative bacteria. The site of injury had varying rates of IC: spine or back (53%), head or neck (44%), torso (43%), and extremity (35%). Injury Severity Score and certain mechanisms of injury (explosive device, bomb, and landmine) were associated with an IC on multivariate analysis (p < 0.01). Conclusion: Infections are common after combat-related injuries. Although the JTTR can provide general information regarding infections, improved data capture and more specific clinical information is necessary to improve overall combat-related injury infection care. C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.; Wilkins, Kenneth; Yun, Heather C.; Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Wilkins, Kenneth] Infect Dis Clin Res Program, Bethesda, MD USA. [Molter, Nancy C.; Dubick, Michael A.; Spott, Mary Ann; Jenkins, Donald; Eastridge, Brian; Holcomb, John B.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil NR 19 TC 29 Z9 29 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S138 EP S144 DI 10.1097/TA.0b013e31819d894c PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100021 PM 19359957 ER PT J AU Murray, CK Johnson, EN Conger, NG Marconi, VC AF Murray, Clinton K. Johnson, Erica N. Conger, Nicholas G. Marconi, Vincent C. TI Occupational Exposure to Blood and Other Bodily Fluids at a Military Hospital in Iraq SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Iraq; Needlestick; Mucosal exposure; Occupational exposure; HIV; Hepatitis B; Hepatitis C; Combat hospital ID INJECTION-DRUG USERS; HEALTH-CARE WORKERS; HEPATITIS-C VIRUS; NEEDLESTICK INJURIES; UNITED-STATES; PREVALENCE; INFECTION; HIV; EMERGENCY; CENTERS AB Background. Exposure to blood-borne pathogens, namely HIV, hepatitis B, and hepatitis C, remains a risk for healthcare workers. Given the austere and challenging environments in a combat zone, it is unclear to what extent blood and other bodily fluid occupational exposures pose a risk of infection for military healthcare workers deployed to a level III military treatment facility in support of Operation Iraqi Freedom. Methods. This is a retrospective review of electronic infection control records at the Air Force Theater Hospital in Iraq in which blood and other bodily fluid occupational exposure data were available: October 1, 2005 through May 31, 2006 and January 15, 2007 through April 30, 2007. Results. During the first study period, there were 46 exposures for an average monthly exposure of 5.8 (range, 2-16 per month). The majority of exposures were percutaneous fingersticks (74%), whereas the remainder were splashes (17%) or not documented (9%). During the second study period, there were 19 exposures with percutaneous device and splash exposure encompassing 68% and 32% of cases, respectively. The majority of occurrences were in the intensive care unit (53%) and primarily among nurses (37%). Overall, there were 65 exposures per 1,000 persons during the year review. Conclusions. During the time periods evaluated, a substantial number of blood and other bodily fluid exposures occurred in a combat zone military healthcare facility. This finding is comparable to US civilian institutions. Maintaining programs for preventing, tracking, and implementing postexposure prophylaxis remain a worthy and achievable goal at every military treatment facility, regardless of the austerity of the environment. C1 [Murray, Clinton K.; Johnson, Erica N.; Marconi, Vincent C.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Conger, Nicholas G.] Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil RI Andrade, Hugo/M-6631-2013; Marconi, Vincent/N-3210-2014 OI Andrade, Hugo/0000-0001-6781-6125; Marconi, Vincent/0000-0001-8409-4689 NR 25 TC 6 Z9 6 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S62 EP S68 DI 10.1097/TA.0b013e31819cdfc8 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100009 PM 19359972 ER PT J AU Nessen, SC Cronk, DR Edens, J Eastridge, BJ Little, TR Windsor, J Blackbourne, LH Holcomb, JB AF Nessen, Shawn C. Cronk, Daniel R. Edens, Jason Eastridge, Brian J. Little, Todd R. Windsor, Jason Blackbourne, Lorne H. Holcomb, John B. TI US Army Two-Surgeon Teams Operating in Remote Afghanistan-An Evaluation of Split-Based Forward Surgical Team Operations SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID FRESH WHOLE-BLOOD; RECEIVING MASSIVE TRANSFUSIONS; DAMAGE CONTROL RESUSCITATION; MULTIPLE ORGAN FAILURE; COMBAT CASUALTIES; TRAUMA PATIENTS; CELL TRANSFUSIONS; INJURED PATIENTS; FROZEN PLASMA; UNITED-STATES AB Background: United States Army Forward Surgical Teams (FSTs) consits of twenty personnel and are the Army's smallest surgical units. Currently, they provide the majority of resuscitative surgical care for combat casualties in Afghanistan where the mission of the FST has been further extended to include "split-based operations." The effectiveness of these 10-person teams is unknown and outcome data has not been previously reported in the literature. This article evaluates the effectiveness of one split FST during a 14-month period in remote Afghanistan. Methods: The primary endpoint was died of wounds (DOW) outcomes among United States Forces, Coalition Afghani Forces, and local national citizens. Mortality was evaluated separately for patients who received a blood transfusion. Secondary endpoints of the study included number of blood products transfused, Injury Severity Score (ISS), and mechanism of injury. Results: Seven hundred sixty-one patients were treated and 327 patients underwent an immediate surgery. The average ISS was 12.05, and the DOW percentage was 2.36%. There were 61 patients with an ISS of greater than 24 (mortality = 23.0%), and 47 patients with an ISS of 16 to 24 (mortality = 2.13%). Nine of 121 patients transfused (7.4%) dies. A total of 27 patients required massive blood transfusion and on average received 12.6 units of fresh frozen plasma and 18.2 units of packed red blood cell (ratio 1:1.49). Seven of 27 patients who received massive blood transfusion (25.9%) died. Conclusions: Small two-surgeon surgical teams can achieve acceptable DOW rates when compared with other larger surgical units currently operating in the Global War on Terror. C1 [Nessen, Shawn C.; Cronk, Daniel R.; Edens, Jason; Eastridge, Brian J.; Little, Todd R.; Windsor, Jason; Blackbourne, Lorne H.; Holcomb, John B.] USA, Inst Surg Res, San Antonio, TX USA. RP Nessen, SC (reprint author), 821 Lazy Acres St,Box 19, Fayetteville, NC 28306 USA. EM shawn.nessen@us.army.mil NR 35 TC 22 Z9 23 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S37 EP S47 DI 10.1097/TA.0b013e31819cc302 PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100005 PM 19359969 ER PT J AU Perkins, JG Andrew, CP Spinella, PC Blackbourne, LH Grathwohl, KW Repine, TB Ketchum, L Waterman, P Lee, RE Beekley, AC Sebesta, JA Shorr, AF Wade, CE Holcomb, JB AF Perkins, Jeremy G. Andrew, Cap P. Spinella, Philip C. Blackbourne, Lorne H. Grathwohl, Kurt W. Repine, Thomas B. Ketchum, Lloyd Waterman, Paige Lee, Ruth E. Beekley, Alec C. Sebesta, James A. Shorr, Andrew F. Wade, Charles E. Holcomb, John B. TI An Evaluation of the Impact of Apheresis Platelets Used in the Setting of Massively Transfused Trauma Patients SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Apheresis platelets; Penetrating injury; Component therapy; Massive transfusion; Combat trauma ID LIFE-THREATENING COAGULOPATHY; DAMAGE CONTROL HEMATOLOGY; BLOOD-PRODUCT UTILIZATION; EXSANGUINATION PROTOCOL; COMBAT CASUALTIES; SHOCK SEVERITY; MORTALITY; EPIDEMIOLOGY; SURVIVAL; DEATHS AB Introduction. Trauma is a major cause of morbidity and mortality worldwide. Of patients arriving to trauma centers, patients requiring massive transfusion (MT, >= 10 units in 24 hours) are a small patient subset but are at the highest risk of mortality. Transfusion of appropriate ratios of blood products to such patients has recently been an area of interest to both the civilian and military medical community. Plasma is increasingly recognized as a critical component, though less is known about appropriate ratios of platelets. Combat casualties managed at the busiest combat hospital in Iraq provided an opportunity to examine this question. Methods. In-patient records for 8,618 trauma casualties treated at the military hospital in Baghdad more than a 3-year interval between January 2004 and December 2006 were retrospectively reviewed and patients requiring MT (n = 694) were identified. Patients who required NIT in the first 24 hours and did not receive fresh whole blood were divided into study groups defined by source of platelets: (1) patient receiving a low ratio of platelets (<1:16 apheresis platelets per stored red cell unit, aPLT:RBC) (n = 214),(2) patients receiving a medium ratio of platelets (1:16 to <1:8 aPLT:RBC) (n = 154), and (3) patients receiving a high ratio of platelets (>= 1:8 aPLT: RBC) (n = 96). The primary endpoint was survival at 24 hours and at 30 days. Results. At 24 hours, patients receiving a high ratio of platelets had higher survival (95%) as compared with patients receiving a medium ratio (87%) and patients receiving the lowest ratio of platelets (64%) (log-rank p = 0.04 and p < 0.001, respectively). The survival benefit for the high and medium ratio groups remained at 30 days as compared with those receiving the lowest ratio of platelets (75% and 60% vs. 43%, p < 0.001 for both comparisons). On multivariate regression, plasma:RBC ratios and aPLT:RBC were both independently associated with improved survival at 24 hours and at 30 days. Conclusion: Transfusion of a ratio of >= 1:8 aPLT:RBC is associated with improved survival at 24 hours and at 30 days in combat casualties requiring a MT within 24 hours of injury. Although prospective study is needed to confirm this finding, MT protocols outside of investigational research should consider incorporation of appropriate ratios of both plasma and platelets. C1 [Perkins, Jeremy G.; Andrew, Cap P.; Waterman, Paige] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Spinella, Philip C.] Connecticut Childrens Med Ctr, Hartford, CT USA. [Blackbourne, Lorne H.; Wade, Charles E.; Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Grathwohl, Kurt W.] Brooke Army Med Ctr, San Antonio, TX USA. [Repine, Thomas B.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Ketchum, Lloyd] Walter Reed Army Inst Res, Silver Spring, MD USA. [Lee, Ruth E.; Beekley, Alec C.; Sebesta, James A.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Shorr, Andrew F.] Washington Hosp Ctr, Washington, DC 20010 USA. RP Perkins, JG (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave, Washington, DC 20307 USA. EM Jeremy.perkins1@us.army.mil NR 34 TC 77 Z9 84 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S77 EP S84 DI 10.1097/TA.0b013e31819d8936 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100011 PM 19359974 ER PT J AU Spinella, PC Perkins, JG Grathwohl, KW Beekley, AC Holcomb, JB AF Spinella, Philip C. Perkins, Jeremy G. Grathwohl, Kurt W. Beekley, Alec C. Holcomb, John B. TI Warm Fresh Whole Blood Is Independently Associated With Improved Survival for Patients With Combat-Related Traumatic Injuries SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Whole blood; Transfusion; Mortality; Survival; Combat ID RECEIVING MASSIVE TRANSFUSIONS; DAMAGE CONTROL RESUSCITATION; RANDOMIZED CONTROLLED-TRIAL; MULTIPLE ORGAN FAILURE; ACTIVATED FACTOR-VII; EARLY COAGULOPATHY; CRITICALLY-ILL; RURAL STATE; UNIVERSAL LEUKOREDUCTION; EXSANGUINATION PROTOCOL AB Background. Increased understanding of the pathophysiology of the acute coagulopathy of trauma has lead many to question the current transfusion approach to hemorrhagic shock. We hypothesized that warm fresh whole blood (WFWB) transfusion would be associated with improved survival in patients with trauma compared with those transfused only stored component therapy (CT). Methods: We retrospectively studied US Military combat casualty patients transfused >= 1 unit of red blood cells (RBCs). The following two groups of patients were compared: (1) WFWB, who were transfused WFWB, RBCs, and plasma but not apheresis platelets and (2) CT, who were transfused RBC, plasma, and apheresis platelets but not WFWB. The primary outcomes were 24-hour and 30-day survival. Results: Of 354 patients analyzed there were 100 in the WFWB and 254 in the CT group. Patients in both groups had similar severity of injury determined by admission eye, verbal, and motor Glasgow Coma Score, base deficit, international normalized ratio, hemoglobin, systolic blood pressure, and injury severity score. Both 24-hour and 30-day survival were higher in the WFWB cohort compared with CT patients, 96 of 100 (96%) versus 223 of 254 (88%), (p = 0.018) and 95% to 82%, (p = 0.002), respectively. An increased amount (825 mL) of additives and anticoagulants were administered to the CT compared with the WFWB group, (p < 0.001). Upon multivariate logistic regression the use of WFWB and the volume of WFWB transfused was independently associated with improved 30-day survival. Conclusions: In patients with trauma with hemorrhagic shock, resuscitation strategies that include WFWB may improve 30-day survival, and may be a result of less anticoagulants and additives with WFWB use in this population. C1 [Spinella, Philip C.] CCMC, Pediat ICU, Hartford, CT 06106 USA. [Spinella, Philip C.; Perkins, Jeremy G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Grathwohl, Kurt W.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Bethesda, MD USA. [Beekley, Alec C.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Spinella, PC (reprint author), CCMC, Pediat ICU, 282 Washington St, Hartford, CT 06106 USA. EM Pspinella@ccmckids.org FU NIGMS NIH HHS [P50 GM038529-19, P50 GM038529] NR 68 TC 121 Z9 133 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S69 EP S76 DI 10.1097/TA.0b013e31819d85fb PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100010 PM 19359973 ER PT J AU Thomas, R McManus, JG Johnson, A Mayer, P Wade, C Holcomb, JB AF Thomas, Roger McManus, John G. Johnson, Anthony Mayer, Paul Wade, Charles Holcomb, John B. TI Ocular Injury Reduction From Ocular Protection Use in Current Combat Operations SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Ocular trauma; Combat eye injury; Combat eye protection ID IRAQI FREEDOM; DESERT-SHIELD; EYE INJURIES; STORM; WAR AB Background: The mechanisms of modern warfare unfortunately have lead to many ocular injuries. This study attempts to quantify the effect of military combat eye protection on the incidence of ocular injury among US service members engaged in current combat operations. Methods: we retrospectively gathered data from the Joint Theater Trauma Registry from patients entering level III hospital facilities in Operations Iraqi and Enduring Freedom from March 2003 to September 2006. The presence of ocular injury was the primary outcome measure; whereas severity of injury and the effect of eye protection education on compliance with wearing this protection were secondary outcome measurements. Results: Ocular protection status at the time of injury was documented in 3,276 casualties during the collection period. Of these, 451 of 2,671 (17%) casualties who reported wearing ocular protection sustained an ocular injury and 155 of 605 (26%) casualties who reported not wearing eye protection suffered an eye injury (p < 0.01). After an intense ocular protection education program, there was a 16% increase in compliance of eye protection use in combat. Finally, when the severity of eye injuries are compared using an abbreviated injury scale, casualties with eye protection had decreased injury severity in addition to incidence (p < 005). Conclusion: This study suggests that the military combat eye protection used by military personnel during current combat operations has resulted in significantly fewer and less severe ocular injuries. Further, results from this study may also suggest that Department of Defense educational programs may have been successful in increasing eye protection compliance. C1 [McManus, John G.; Wade, Charles; Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Thomas, Roger; McManus, John G.; Johnson, Anthony] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Mayer, Paul] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. RP McManus, JG (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 13 TC 25 Z9 27 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S99 EP S103 DI 10.1097/TA.0b013e31819d8695 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100016 PM 19359977 ER PT J AU White, CE Simmons, JW Holcomb, JB Aydelotte, JD Eastridge, BJ Blackbourne, L AF White, Christopher E. Simmons, John W. Holcomb, John B. Aydelotte, Jayson D. Eastridge, Brian J. Blackbourne, Lorne TI Impact of Extremity Amputation on Combat Wounded Undergoing Exploratory Laparotomy SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Trauma; Combat wounds; Amputations; Hemorrhage; Massive transfusion; Time; Iraq; OIF ID ABDOMINAL COMPARTMENT SYNDROME; DAMAGE CONTROL RESUSCITATION; OPERATION-ENDURING-FREEDOM; MULTIPLE ORGAN FAILURE; FRESH-FROZEN PLASMA; MASSIVE TRANSFUSION; BLOOD-TRANSFUSION; EARLY PREDICTORS; INJURY SEVERITY; IRAQI-FREEDOM AB Background: Combat casualties with traumatic amputations (TA) and requiring laparotomy present unique clinical challenges. The purpose of this study was to determine the association of TA on blood/blood product usage, emergency department (ED) and operating room (OR) times, and mortality in those undergoing exploratory laparotomy after combat injury. Methods: A retrospective study was performed at one combat support hospital in Iraq of patients requiring exploratory laparotomy for abdominal injury. These patients were divided into two cohorts based on the presence or absence of TA. Initial vital signs, international normalization ratio, pH, blood product usage, time in ED and OR, and mortality were compared between groups. Results: We reviewed 171 consecutive laparotomies performed between September 2007 and May 2008. Twenty one were identified with TA. Presenting systolic pressure, hemoglobin, platelets, international normalization ratio, and arterial pH did not differ between groups. The TA group presented more tachycardic, received more blood/blood products in ED and OR, and were more likely to meet requirements of massive transfusion. There was no difference in mortality between groups. Time in ED was shorter and time in OR was longer for the TA cohort. Conclusion: TA with penetrating abdominal injuries are associated with increased transfusions of blood products beginning at patient arrival. Massive transfusion protocols should be activated as soon as this injury is identified. The severity of this injury pattern was only manifested by an increased heart rate at admission. TA with abdominal injury spent less time in ED and a longer time in OR; however, there was no increase in mortality. C1 [White, Christopher E.; Simmons, John W.; Eastridge, Brian J.; Blackbourne, Lorne] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, Houston, TX USA. [Aydelotte, Jayson D.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP White, CE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM christopher.eric.white@us.army.mil NR 38 TC 4 Z9 4 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 2009 VL 66 IS 4 BP S86 EP S92 DI 10.1097/TA.0b013e31819ce22c PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 431OW UT WOS:000265073100013 PM 19359975 ER PT J AU Bonhage, MR Chilcoat, CD Li, Q Melendez, V Flournoy, WS AF Bonhage, M. R. Chilcoat, C. D. Li, Q. Melendez, V. Flournoy, W. S. TI Evaluation of two scopolamine and physostigmine pretreatment regimens against nerve agent poisoning in the dog SO JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS LA English DT Article ID GUINEA-PIGS; ADJUNCT PRETREATMENT; VX INTOXICATION; SOMAN TOXICITY; PHARMACODYNAMICS; PHARMACOKINETICS; PROTECTION; HYOSCINE; EFFICACY; SARIN AB Currently, there is no viable protection against chemical warfare agents for the working dog. Physostigmine (PHY) and scopolamine (SCO) have been shown to protect dogs against nerve agents with minimal side effects. The goal of this study was to investigate whether reported protective SCO/PHY plasma concentrations of 0.2 and 0.7 ng/mL, respectively, could be reached and maintained with minimal side-effects thereby identifying possible pretreatment regimens. Two continuous regimens of SCO/PHY were administered to beagle dogs. The first regimen consisted of administering transdermal SCO and intraocular PHY, the second consisted of transdermal SCO and rectal PHY. SCO/PHY plasma concentrations for each regimen were determined, individual protective times were calculated and a computerized pharmacokinetic analysis was performed. The results showed transdermal SCO and intraocular PHY routes of delivery achieved sustained protective drug concentrations with minimal side-effects and the rectal route of delivery did not. Group median protective times for the first regimen were 54.45 h for SCO and 64.35 h for PHY, and for the second regimen 63.75 h for SCO and 0 h for PHY. The combined transdermal patch and intraocular regimen may provide a safe and effective regimen against nerve agent poisoning in dogs. C1 [Bonhage, M. R.] Armed Forces Inst Pathol, Div Lab Anim Med, Dept Vet Pathol, Washington, DC 20306 USA. [Chilcoat, C. D.] Walter Reed Army Inst Res, Div Pathol, Dept Mol Pathol, Silver Spring, MD USA. [Li, Q.] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Pharmacol, Silver Spring, MD USA. [Melendez, V.] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Med Chem, Silver Spring, MD USA. [Flournoy, W. S.] USA, Ft Shafter, HI USA. RP Bonhage, MR (reprint author), 14th & Alaska Ave,Bldg 54 RmG 117, Washington, DC 20306 USA. EM michael.bonhage@osd.afip.mil NR 30 TC 1 Z9 1 U1 2 U2 10 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0140-7783 J9 J VET PHARMACOL THER JI J. Vet. Pharmacol. Ther. PD APR PY 2009 VL 32 IS 2 BP 146 EP 153 DI 10.1111/j.1365-2885.2008.01013.x PG 8 WC Pharmacology & Pharmacy; Veterinary Sciences SC Pharmacology & Pharmacy; Veterinary Sciences GA 415WI UT WOS:000263966800006 PM 19290944 ER PT J AU Ter-Gabrielyan, N Merkle, LD Newburgh, GA Dubinskii, M AF Ter-Gabrielyan, N. Merkle, L. D. Newburgh, G. A. Dubinskii, M. TI Resonantly-pumped Er(3+):Y(2)O(3) ceramic laser for remote CO(2) monitoring SO LASER PHYSICS LA English DT Article AB Laser performance of resonantly-pumped Er(3+)-doped Y(2)O(3) ceramic laser for remote DIAL CO(2) monitoring is reported. Slope efficiency of 64.6% and output power of over 9.3 W have been achieved with this eyesafe, 1.6-mu m, CW laser in a cryogenically cooled operation regime despite the marginal optical quality of currently available laser gain material. C1 [Ter-Gabrielyan, N.; Merkle, L. D.; Newburgh, G. A.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army FU High Energy Laser Joint Technology Office FX This work was partially supported by the High Energy Laser Joint Technology Office. NR 6 TC 22 Z9 22 U1 0 U2 8 PU MAIK NAUKA/INTERPERIODICA/SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 1054-660X J9 LASER PHYS JI Laser Phys. PD APR PY 2009 VL 19 IS 4 BP 867 EP 869 DI 10.1134/S1054660X09040458 PG 3 WC Optics; Physics, Applied SC Optics; Physics GA 431EG UT WOS:000265043500045 ER PT J AU Dubinskii, M Zhang, J Kudryashov, I AF Dubinskii, M. Zhang, J. Kudryashov, I. TI Power scaling of resonantly cladding-pumped, Yb-free, Er-doped LMA fiber lasers SO LASER PHYSICS LA English DT Article AB The results of the recent major efforts in power scaling of resonantly cladding-pumped Yb-free Er fiber lasers are presented. Commercially available Yb-free Er-doped large mode area Er60-20/125 (LMA) DC fibers were tested in two regimes: (i), as a booster amplifier in a single-frequency (SF) MOPA configuration and, (ii), in a Bragg grating (FBG) based narrowband fiber laser configuration. We obtained similar to 28.5 W of output power at 1590 nm, the highest power reported so far out of Yb-free Er-doped LMA fiber with resonant cladding pumping. The achieved optical-to-optical conversion slope efficiency of similar to 56.6% is also believed to be the highest efficiency ever reported from Yb-free Er-doped fiber laser with resonant cladding pumping. C1 [Dubinskii, M.; Zhang, J.] USA, Res Lab, Adelphi, MD 20783 USA. [Kudryashov, I.] Princeton Lightwave Inc, Cranbury, NJ 08512 USA. RP Dubinskii, M (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil FU High Energy Laser Joint Technology Office FX This work was partially supported by the High Energy Laser Joint Technology Office. NR 9 TC 4 Z9 4 U1 2 U2 2 PU MAIK NAUKA/INTERPERIODICA/SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 1054-660X J9 LASER PHYS JI Laser Phys. PD APR PY 2009 VL 19 IS 4 BP 902 EP 905 DI 10.1134/S1054660X09040513 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA 431EG UT WOS:000265043500051 ER PT J AU Anam, K Amare, M Naik, S Szabo, KA Davis, TA AF Anam, K. Amare, M. Naik, S. Szabo, K. A. Davis, T. A. TI Severe tissue trauma triggers the autoimmune state systemic lupus erythematosus in the MRL/++ lupus-prone mouse SO LUPUS LA English DT Article DE autoimmunity; burns; lupus; SLE; trauma ID APOPTOTIC CELLS; THERMAL-INJURY; GENE-EXPRESSION; RISK-FACTORS; INTERLEUKIN-12 PRODUCTION; CYTOKINE PRODUCTION; IGG3 CRYOGLOBULINS; 2-TYPE CYTOKINES; IMMUNE-RESPONSE; MAJOR INJURY AB Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MRL/++ mice (chronic model) exhibit autoimmune symptoms at > 70 weeks of age, whereas MRL/-Fas(lpr) mice (acute model) develop autoimmune disease in 17 22 weeks due to a lymphoproliferative mutation. Autoimmune disease developed inMRL/++ mice (4-15 weeks post injury) is manifested by skin lesions, vasculitis, epidermal ulcers, cellular infiltration, splenomegaly, lymphadenopathy, hypergammaglobulinemia, elevated autoantibodies and renal pathologies including proteinuria, glomerulonephritis and immune complex deposition; complications that contribute to reduced survival. Transcription studies of wound margin tissue show a correlation between the pathogenic effects of dysregulated IL-1 beta, IL-6, TNF-alpha and PGE(2) synthesis during early wound healing and early onset of autoimmune disease. Interestingly, MRL/++ mice with healed wounds (30-40 days post burn) strongly rejected skin isografts. Conversely, skin isografts transplanted onto naive age-matched MRL/++ littermates achieved long-term survival. Collectively, these findings suggest that traumatic injury exacerbates inflammatory skin disease and severe multi-organ pathogenesis in lupus-prone mice. Lupus (2009) 18, 318-331. C1 [Anam, K.; Amare, M.; Naik, S.; Davis, T. A.] USN, Regenerat Med Dept, Med Res Ctr, Silver Spring, MD 20910 USA. [Szabo, K. A.] Walter Reed Army Inst Res, Dept Diagnost Pathol, Silver Spring, MD USA. RP Anam, K (reprint author), USN, Regenerat Med Dept, Med Res Ctr, Room 2A10,503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM thomas.davis1@med.navy.mil FU ONR work FX This work was prepared as part of their official duties. Title 17 U. S. C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U. S. C 101 defined a US Government work as a work prepared by a military service member or employees of the US Government as part of that person's official duties. The opinions or assertions contained in this article are the private views of the authors and are not to be construed as reflecting the views, policy or positions of the Department of the Navy, Department of the Army, Department of Defense or the US Government. The experiments reported herein were conducted in compliance with the Animal Welfare Act and in accordance with the principles set forth in the current edition of the Guide for Care and Use of Laboratory Animals, Institute for Laboratory Animal Resources, National Research Council, National Academy Press, 1996. NR 82 TC 10 Z9 10 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0961-2033 J9 LUPUS JI Lupus PD APR PY 2009 VL 18 IS 4 BP 318 EP 331 DI 10.1177/0961203308097479 PG 14 WC Rheumatology SC Rheumatology GA 420WO UT WOS:000264320100006 PM 19276300 ER PT J AU Giorno, R Mallozzi, M Bozue, J Moody, KS Slack, A Qiu, DL Wang, R Friedlander, A Welkos, S Driks, A AF Giorno, Rebecca Mallozzi, Michael Bozue, Joel Moody, Krishna-Sulayman Slack, Alex Qiu, Dengli Wang, Rong Friedlander, Arthur Welkos, Susan Driks, Adam TI Localization and assembly of proteins comprising the outer structures of the Bacillus anthracis spore SO MICROBIOLOGY-SGM LA English DT Article ID COAT-SURFACE-MORPHOLOGY; PROTECTIVE ANTIGEN; IMMUNODOMINANT PROTEIN; FORMING BACTERIA; GUINEA-PIGS; EXOSPORIUM; SUBTILIS; BCLA; CEREUS; MORPHOGENESIS AB Bacterial spores possess a series of concentrically arranged protective structures that contribute to dormancy, survival and, ultimately, germination. One of these structures, the coat, is present in all spores. In Bacillus anthracis, however, the spore is surrounded by an additional, poorly understood, morphologically complex structure called the exosporium. Here, we characterize three previously discovered exosporium proteins called ExsFA (also known as BxpB), ExsFB (a highly related paralogue of exsFA/bxpB) and lunH (similar to an inosine-uridine-pref erring nucleoside hydrolase). We show that in the absence of ExsFA/BxpB, the exosporium protein BclA accumulates asymmetrically to the forespore pole closest to the midpoint of the sporangium (i.e. the mother-cell-proximal pole of the forespore), instead of uniformly encircling the exosporium. ExsFA/BxpB may also have a role in coat assembly, as mutant spore surfaces lack ridges seen in wild-type spores and have a bumpy appearance. ExsFA/BxpB also has a modest but readily detected effect on germination. Nonetheless, an exsFA/bxpB mutant strain is fully virulent in both intramuscular and aerosol challenge models in Guinea pigs. We show that the pattern of localization of ExsFA/BxpB-GFP is a ring, consistent with a location for this protein in the basal layer of the exosporium. In contrast, ExsFB-GFP fluorescence is a solid oval, suggesting a distinct subcellular location for ExsFB-GFP. We also used these fusion proteins to monitor changes in the subcellular locations of these proteins during sporulation. Early in sporulation, both fusions were present throughout the mother cell cytoplasm. As sporulation progressed, GFP fluorescence moved from the mother cell cytoplasm to the forespore surface and formed either a ring of fluorescence, in the case of ExsFA/BxpB, or a solid oval of fluorescence, in the case of ExsFB. lunH-GFP also resulted in a solid oval of fluorescence. We suggest the interpretation that at least some ExsFB-GFP and lunH-GFP resides in the region between the coat and the exosporium, called the interspace. C1 [Giorno, Rebecca; Mallozzi, Michael; Slack, Alex; Driks, Adam] Loyola Univ, Med Ctr, Dept Microbiol & Immunol, Maywood, IL 60153 USA. [Bozue, Joel; Moody, Krishna-Sulayman; Welkos, Susan] USA, Med Res Inst Infect Dis, Bacterial Div, Ft Detrick, MD 21702 USA. [Qiu, Dengli; Wang, Rong] IIT, Dept Biol Chem & Phys Sci, Chicago, IL 60616 USA. RP Driks, A (reprint author), Loyola Univ, Med Ctr, Dept Microbiol & Immunol, 2160 S 1st Ave, Maywood, IL 60153 USA. EM adriks@lumc.edu FU NIH [A153365]; US Army Medical Research and Materiel Command [02-4-5C-0 18, 02-4-5C-023]; Award from the Department of the Artily under [92489] FX The authors thank Kathy Kuehl [Pathology Department, United States Army Medical Research Institute of Infectious Diseases (USAMRIID)] for preparation of electron microscope samples and Sarah Norris (USAMRIID) for statistical analysis. We thank Terri Koehler (University of Texas, Houston) for the kind gift of CP-51, plasmids and strains, and for valuable advice. We thank Peter McKenney and Patrick Eichenberger for important input into this study. Funding was provided by the NIH (A153365, A. D.) and the US Army Medical Research and Materiel Command under Projects 02-4-5C-0 18 (J. B.), 02-4-5C-023 (S.W.) and 04-0-IL-002 (S.W.) and an In-HOLIse Laboratory Innovative Research Award from the Department of the Artily under Project 92489 (J. B.). Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals (Institute of Laboratory Animal Resources et at., 1996). The facility in which this research was conducted is fully accredited by the Association for Assessnient and Accreditation of Laboratory Animal Care International. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army. NR 72 TC 25 Z9 25 U1 0 U2 11 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1350-0872 J9 MICROBIOL-SGM JI Microbiology-(UK) PD APR PY 2009 VL 155 BP 1133 EP 1145 DI 10.1099/mic.0.023333-0 PG 13 WC Microbiology SC Microbiology GA 435CT UT WOS:000265321700014 PM 19332815 ER PT J AU Friedl, KE Grate, SJ Proctor, SP AF Friedl, Karl E. Grate, Stephen J. Proctor, Susan P. TI Neuropsychological Issues in Military Deployments: Lessons Observed in the DoD Gulf War Illnesses Research Program SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; US ARMY VETERANS; POSTWAR HOSPITALIZATION EXPERIENCE; COMPREHENSIVE CLINICAL-EVALUATION; CHEMICAL MUNITIONS DESTRUCTION; AMYOTROPHIC-LATERAL-SCLEROSIS; DEPLETED URANIUM PELLETS; CHRONIC-FATIGUE-SYNDROME; SELF-REPORTED EXPOSURES; PARKINSONS-DISEASE AB The U.S. Department of Defense invested $150 M to investigate undiagnosed Gulf War Illnesses (GWI) and twice that amount in post hoc clinical management. No new disease syndrome was identified, but the research produced new understanding and awareness of important psychosocial and neurotoxicological interactions that represented a difficult and relatively untapped frontier in biomedical research, especially concerning chronic multisymptom illnesses. Some specific Gulf War issues such as effects of depleted uranium, Leishmania diagnosis and treatment, and pesticide and prophylactic drug interactions have been intensively investigated; remaining priorities for further investigation include: markers of neurologic change (e.g., neuroimaging, neuropsychological testing), interactions between psychological resilience and neurotoxicity, structure function relationships of neurotoxins with neurodegenerative disease potential, and predictors of individual susceptibility. The primary conclusions from the program are that no specific neurotoxic chemical has been identified that explains the chronic multisymptom illness observed but wellness of service members in future deployments may be better sustained based on continuing research on preexposure health baselining, fitness and health-damaging behaviors, and stress resilience. The many scientific discoveries and accomplishments of the GWI research effort have advanced military medical science, provided a solid basis on which to build future protections against health and performance risks to the warfighter, and improved the ability to respond to future deployment health issues. C1 [Friedl, Karl E.; Grate, Stephen J.] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Proctor, Susan P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Friedl, KE (reprint author), USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. OI Friedl, Karl/0000-0002-3134-8427 NR 136 TC 8 Z9 9 U1 4 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2009 VL 174 IS 4 BP 335 EP 346 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA 601LB UT WOS:000278059600004 PM 19485101 ER PT J AU Rabinowitz, YG Breitbach, JE Warner, CH AF Rabinowitz, Yaron G. Breitbach, Jill E. Warner, Christopher H. TI Managing Aviator Fatigue in a Deployed Environment: The Relationship Between Fatigue and Neurocognitive Functioning SO MILITARY MEDICINE LA English DT Article ID PERFORMANCE; PERSONNEL; IMPACT; WORK AB The current military battlefield requires aviators to make split-second decisions that often have life-and-death consequences, making identifying predictors of diminished cognitive performance a vital aeromedical and safety concern. The current study explored the relationship between aviator effectiveness, as determined by sleep wake patterns, and neurocognitive functioning in a brigade-size rotary wing aviation element deployed in Iraq. Actigraphy and the Fatigue Avoidance Scheduling Tool (FAST) were used to assess the ratio of sleep wake patterns over a 24-hour time period, and a computerized multitasking measure, which mimics the task demands of flying, was utilized to evaluate neurocognitive functioning during preflight operations. Results showed a significant positive association between level of effectiveness and neurocognitive functioning before flight operations. The reported sleep habits and trends in types of sleep difficulties are noted. The results speak to the potential efficacy of using actigraphy and software to evaluate a pilot's effectiveness before flight operations, and suggest that flight surgeons and psychologists may be able to play a vital role in improving overall sleep patterns and enhancing the warfighting efforts of aviators in combat. They also suggest that mandated crew rest and evaluation of total reported sleep time may not be sufficient to ensure optimum performance levels. C1 [Rabinowitz, Yaron G.] Texas A&M Univ, Dept Psychol, Corpus Christi, TX 78412 USA. [Breitbach, Jill E.] Tripler Army Med Ctr, Dept Psychol, Honolulu, HI 96859 USA. [Warner, Christopher H.] 3rd Infantry Div, Div Psychiatrist, Ft Stewart, GA 31314 USA. RP Rabinowitz, YG (reprint author), Texas A&M Univ, Dept Psychol, Corpus Christi, TX 78412 USA. NR 13 TC 5 Z9 5 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2009 VL 174 IS 4 BP 358 EP 362 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 601LB UT WOS:000278059600007 PM 19485104 ER PT J AU Mitchener, TA Hauret, KG AF Mitchener, Timothy A. Hauret, Keith G. TI Air Medical Evacuations of Soldiers for Oral-Facial Disease and Injuries, 2005, Operations Enduring Freedom/Iraqi Freedom SO MILITARY MEDICINE LA English DT Article AB This retrospective study was conducted to assess the nature and causes of serious oral-facial illnesses and injuries among U.S. Army personnel deployed to Iraq and Afghanistan in 2005. Information for this study came from the U.S. Air Force Transportation Regulating and Command and Control Evacuation System (TRAC2ES) database for medical evacuations (MEDEVACS) for 2005. The study found 171 oral-facial MEDEVACS out of Iraq (cumulative incidence: 13.3/10,000 soldiers per year) and 35 out of Afghanistan (cumulative incidence: 21.6/10,000 soldiers per year), a total of 206 MEDEVACS. Fifty-three percent (n = 109) of oral-facial MEDEVACS were for battle injuries caused by acts of war. Thirty-one percent of all oral-facial MEDEVACS (n = 64) were for diseases of the oral cavity, salivary glands, and jaw. Sixteen percent (n = 33) of oral-facial MEDEVACS were for nonbattle injuries, primarily fractures of the face bones, for the most part because of motor vehicle accidents. C1 [Mitchener, Timothy A.; Hauret, Keith G.] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. RP Mitchener, TA (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. NR 6 TC 5 Z9 7 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2009 VL 174 IS 4 BP 376 EP 381 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 601LB UT WOS:000278059600010 PM 19485107 ER PT J AU Roberts, SS Kazragis, RJ AF Roberts, Stephen S. Kazragis, Robert J. TI Methicillin-Resistant Staphylococcus aureus Infections in US Service Members Deployed to Iraq SO MILITARY MEDICINE LA English DT Article ID SOFT-TISSUE INFECTIONS; EMERGENCY-DEPARTMENT; RISK-FACTORS; SKIN; POPULATION AB Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become the most common cause of skin and soft-tissue infections in the United States. However, no studies have yet examined its importance in the deployed environment. We retrospectively reviewed culture results obtained at a level II military treatment facility in Iraq over a 5-month period to determine the incidence of CA-MRSA in this population. Eighty-five percent of the cultures obtained from skin abscesses were positive for S. aureus, and 70% were methicillin-resistant S. aureus. All of the isolates recovered were sensitive to trimethoprim/sulfamethoxazole. CA-MRSA is a significant problem in deployed service members and civilians and empiric antibiotics for skin and soft-tissue infections need to provide coverage for this important pathogen. C1 [Roberts, Stephen S.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Kazragis, Robert J.] Eisenhower Army Med Ctr, Div Infect Dis, Dept Med, Ft Gordon, GA 30905 USA. RP Roberts, SS (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 19 TC 13 Z9 13 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2009 VL 174 IS 4 BP 408 EP 411 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 601LB UT WOS:000278059600015 PM 19485112 ER PT J AU Klein, TA Pacha, LA Lee, HCS Kim, HC Lee, WJ Lee, JK Jeung, GG Sames, WJ Gaydos, JC AF Klein, Terry A. Pacha, Laura A. Lee, Hee-Choon S. Kim, Heung-Chul Lee, Won-Ja Lee, Jong-Koo Jeung, Gi-Gon Sames, William J. Gaydos, Joel C. TI Plasmodium vivax Malaria Among US Forces Korea in the Republic of Korea, 1993-2007 SO MILITARY MEDICINE LA English DT Article ID DEMILITARIZED ZONE; OUTBREAK AB Malaria is a significant health threat to U.S. combat forces that are deployed to malaria-endemic regions. From 1979, when the Republic of Korea (ROK) was declared malaria free, malaria did not present a health threat to U.S. forces deployed to Korea until the early 1990s. In 1993, a temperate strain of vivax malaria expressing both latent (long prepatent incubation periods of usually 6-18 months after infection) and nonlatent (short prepatent incubation periods <30 days after infection) disease reemerged near the demilitarized zone (DMZ) and once again presented a primary health threat to U.S. military populations in the ROK. Following its reemergence, malaria rates increased dramatically through 1998 and accounted for >44% of all malaria cases among U.S. Army soldiers from 1997 to 2002. More than 60% of all Korean-acquired malaria among U.S. soldiers was identified as latent malaria. Nearly 80% of all latent malaria attributed to exposure in Korea was diagnosed in the U.S. or other countries where soldiers were deployed. These data illustrate the requirement for a comprehensive malaria education program, especially for those soldiers residing or training in malaria high-risk areas, to inform soldiers and providers of the risk of developing malaria after leaving Korea. C1 [Klein, Terry A.] USA, MEDDAC Korea, Dept Prevent Med, APO, AP 96205 USA. [Pacha, Laura A.] Martin Army Community Hosp, Dept Prevent Med, Ft Benning, GA 31905 USA. [Lee, Hee-Choon S.] Walter Reed Army Med Ctr, Dept Prevent Med, Washington, DC 20307 USA. [Kim, Heung-Chul] 5th Med Detachment, APO, AP 96205 USA. [Lee, Won-Ja; Lee, Jong-Koo] Korea Ctr Dis Control & Prevent, Seoul, South Korea. [Jeung, Gi-Gon] ROK Army, Chief Vet Corps, Taejon, South Korea. [Sames, William J.] Def Logist Agcy, Ft Belvoir, VA 22060 USA. [Gaydos, Joel C.] Ctr Hlth Promot & Prevent Med, Silver Spring, MD USA. RP Klein, TA (reprint author), USA, MEDDAC Korea, Dept Prevent Med, APO, AP 96205 USA. RI LEE, Jong-koo/E-4166-2012; Lee, JongGu/B-7384-2013; Valle, Ruben/A-7512-2013 FU U.S. Department of Defense Global Emerging Infections Surveillance and Response System, Silver Spring, MD FX We thank personnel from the 121st Combat Support Hospital (formerly 121st General Hospital) and the Troop Medical Clinics, 168th Multifunctional Medical Battalion, 18th Medical Command, and the health care providers of the 2nd Infantry Division for their support and timely reporting. We acknowledge Ms. Suk-Hee Yi for providing data analysis and the Korean Ministry of Health (Korea Center for Disease Control and Prevention and Korea National Institutes of Health) and Regional Medical Commands for their assistance in monitoring malaria incidence. We appreciate the support provided by personnel of the U.S. Army Medical Surveillance Activity, Walter Reed Army Institute of Research, Silver Spring, MD, who provided data and information on malaria in U.S. soldiers worldwide. Funding for portions of this work was provided by the U.S. Department of Defense Global Emerging Infections Surveillance and Response System, Silver Spring, MD. NR 47 TC 18 Z9 20 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD APR PY 2009 VL 174 IS 4 BP 412 EP 418 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 601LB UT WOS:000278059600016 PM 19485113 ER PT J AU Murphree, R Hackwell, N Mead, PS Bachand, A Stromdahl, EY AF Murphree, Rendi Hackwell, Nita Mead, Paul S. Bachand, Annette Stromdahl, Ellen Y. TI Prospective Health Assessment of Fort Campbell, Kentucky Patrons Bitten by Ticks SO MILITARY MEDICINE LA English DT Article ID AMBLYOMMA-AMERICANUM ACARI; IXODES-SCAPULARIS ACARI; LYME-DISEASE SPIROCHETE; LONE STAR TICK; BORRELIA-LONESTARI DNA; ERYTHEMA MIGRANS; UNITED-STATES; RASH ILLNESS; DERMACENTOR-VARIABILIS; EHRLICHIA-EWINGII AB Amblyomma americanum is an aggressive human-biting tick that transmits several known human pathogens and is associated with a Lyme disease-like illness of unknown etiology. To determine the frequency, distinguishing clinical characteristics, and etiology of A. americanum-associated illness and identify associated risk factors, a prospective study of adult tick-bite victims was conducted at Fort Campbell from 2005-2007. Forty-two participants submitted ticks, none of which contained Borrelia lonestari or B. burgdolferi DNA. Thirty-three participants completed a follow-up health survey; 14 reported at least one symptom; two had erythema migrans-like rash; eight sought medical evaluation for their symptoms. Findings suggest that a variety of symptoms are temporally associated with tick bite but data provide no clear evidence that reported symptoms were caused by an infectious process. Removing a tick by hand or being bitten on a limb may be a risk factor for illness. C1 [Murphree, Rendi; Mead, Paul S.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Murphree, Rendi; Bachand, Annette] Colorado State Univ, Ft Collins, CO 80523 USA. [Hackwell, Nita] Blanchfield Army Community Hosp, Environm Hlth Sect, Ft Campbell, KY 42223 USA. [Stromdahl, Ellen Y.] US Army, Ctr Hlth Promot & Prevent Med, Entomol Sci Program, Aberdeen Proving Ground, MD 21010 USA. RP Murphree, R (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA. NR 41 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2009 VL 174 IS 4 BP 419 EP 425 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 601LB UT WOS:000278059600017 PM 19485114 ER PT J AU Stuart, GR Copeland, WC Strand, MK AF Stuart, Gregory R. Copeland, William C. Strand, Micheline K. TI Construction and application of a protein and genetic interaction network (yeast interactome) SO NUCLEIC ACIDS RESEARCH LA English DT Article ID TRANSCRIPTIONAL REGULATORY NETWORKS; DNA-POLYMERASE-GAMMA; SACCHAROMYCES-CEREVISIAE; MITOCHONDRIAL-DNA; CELL CYCLE; GLUCOSE; EXPRESSION; PATHWAYS; PROVIDE; CAT8 AB Cytoscape is a bioinformatic data analysis and visualization platform that is well-suited to the analysis of gene expression data. To facilitate the analysis of yeast microarray data using Cytoscape, we constructed an interaction network (interactome) using the curated interaction data available from the Saccharomyces Genome Database (www. yeastgenome.org) and the database of yeast transcription factors at YEASTRACT (www.yeastract.com). These data were formatted and imported into Cytoscape using semi-automated methods, including Linux-based scripts, that simplified the process while minimizing the introduction of processing errors. The methods described for the construction of this yeast interactome are generally applicable to the construction of any interactome. Using Cytoscape, we illustrate the use of this interactome through the analysis of expression data from a recent yeast diauxic shift experiment. We also report and briefly describe the complex associations among transcription factors that result in the regulation of thousands of genes through coordinated changes in expression of dozens of transcription factors. These cells are thus able to sensitively regulate cellular metabolism in response to changes in genetic or environmental conditions through relatively small changes in the expression of large numbers of genes, affecting the entire yeast metabolome. C1 [Stuart, Gregory R.; Copeland, William C.; Strand, Micheline K.] NIEHS, Mol Genet Lab, Res Triangle Pk, NC 27709 USA. [Strand, Micheline K.] USA, Res Off, Div Life Sci, Res Triangle Pk, NC 27709 USA. RP Copeland, WC (reprint author), NIEHS, Mol Genet Lab, Res Triangle Pk, NC 27709 USA. EM copelan1@niehs.nih.gov FU National Institutes of Health; National Institute of Environmental Health Sciences [Z01-ES065078]; US Army Research Office [W991NF-04-D0001, DAAG55-98-D-0002]; National Research Council Research Associateship Award; Intramural Research Program FX National Institutes of Health, National Institute of Environmental Health Sciences (Z01-ES065078 to W. C. C.); US Army Research Office (W991NF-04-D0001 and DAAG55-98-D-0002 to G. R. S.); National Research Council Research Associateship Award. Funding for open access charge: Intramural Research Program, National Institutes of Health, National Institute of Environmental Health Sciences. NR 28 TC 6 Z9 6 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-1048 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD APR PY 2009 VL 37 IS 7 AR e54 DI 10.1093/nar/gkp140 PG 12 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 441AM UT WOS:000265741600037 PM 19273534 ER PT J AU Demirbilek, Z Morrison, D AF Demirbilek, Zeki Morrison, Denby TI Tribute to Subrata Kumar Chakrabarti Obituary SO OCEAN ENGINEERING LA English DT Biographical-Item C1 [Demirbilek, Zeki] USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. [Morrison, Denby] Shell Int Explorat & Prod Inc, EP Projects, Houston, TX 77001 USA. RP Demirbilek, Z (reprint author), USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. EM zeki.demirbilek@usace.army.mil; denby.morrison@shell.com NR 1 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD APR PY 2009 VL 36 IS 5 BP 321 EP 323 DI 10.1016/j.oceaneng.2009.02.008 PG 3 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 442BD UT WOS:000265813900001 ER PT J AU Vrabec, JT Backous, DD Djalilian, HR Gidley, PW Leonetti, JP Marzo, SJ Morrison, D Ng, M Ramsey, MJ Schaitkin, BM Smouha, E Toh, EH Wax, MK Williamson, RA Smith, EO AF Vrabec, Jeffrey T. Backous, Douglas D. Djalilian, Hamid R. Gidley, Paul W. Leonetti, John P. Marzo, Sam J. Morrison, Daniel Ng, Matthew Ramsey, Mitchell J. Schaitkin, Barry M. Smouha, Eric Toh, Elizabeth H. Wax, Mark K. Williamson, Robert A. Smith, E. O'Brian CA Facial Nerve Disorders Comm TI Facial Nerve Grading System 2.0 SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID HOUSE-BRACKMANN; AGREEMENT AB OBJECTIVE: To present an updated version of the original Facial Nerve Grading Scale (FNGS), commonly referred to as the House-Brackmann scale. STUDY DESIGN: Controlled trial of grading systems using a series of 21 videos of individuals with varying degrees of facial paralysis. RESULTS: The intraobserver and interobserver agreement was high among the original and revised scales. Nominal improvement is seen in percentage of exact agreement of grade and reduction of instances of examiners differing by more then one grade when using! FNGS 2.0. FNGS 2.0 also offers improved agreement in differentiating between grades 3 and 4. CONCLUSION: FNGS 2.0 incorporates regional scoring of facial movement, providing additional information while maintaining agreement comparable to the original scale. Ambiguities regarding use of the grading, scale are addressed. C1 [Vrabec, Jeffrey T.; Williamson, Robert A.] Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, Houston, TX 77030 USA. [Smith, E. O'Brian] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA. [Backous, Douglas D.] Virginia Mason Med Ctr, Seattle, WA 98101 USA. [Djalilian, Hamid R.] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Irvine, CA 92717 USA. [Gidley, Paul W.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Leonetti, John P.; Marzo, Sam J.] Loyola Univ, Med Ctr, Loyola Ctr Cranial Base Surg, Maywood, IL 60153 USA. [Morrison, Daniel] Dartmouth Hitchcock Med Ctr, Dept Otolaryngol, Lebanon, NH 03766 USA. [Ng, Matthew] Univ Nevada, Sch Med, Dept Surg, Div Otolaryngol, Las Vegas, NV 89154 USA. [Ramsey, Mitchell J.] Tripler Army Med Ctr, Div Otolaryngol, Honolulu, HI 96859 USA. [Schaitkin, Barry M.] Univ Pittsburgh, Dept Otolaryngol, Sch Med, Pittsburgh, PA 15260 USA. [Smouha, Eric] Mt Sinai Med Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10029 USA. [Toh, Elizabeth H.] Lahey Clin Fdn, Dept Otolaryngol, Burlington, MA USA. [Wax, Mark K.] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. RP Vrabec, JT (reprint author), Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, 6550 Fannin St,Suite 1727, Houston, TX 77030 USA. EM jvrabec@bcm.tmc.edu FU NCI NIH HHS [P30 CA016672] NR 10 TC 45 Z9 51 U1 1 U2 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2009 VL 140 IS 4 BP 445 EP 450 DI 10.1016/j.otohns.2008.12.031 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 425FP UT WOS:000264622700002 PM 19328328 ER PT J AU Acevedo, JL Lander, L Choi, S Shah, RK AF Acevedo, Jason L. Lander, Lina Choi, Sukgi Shah, Rahul K. TI Airway management in pediatric epiglottitis: A national perspective SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID RESOURCE UTILIZATION; B DISEASE; CHILDREN; SYDNEY AB OBJECTIVES: The purpose of this study was to describe current demographics and resource utilization in the treatment of pediatric epiglottitis. STUDY DESIGN: Case series from a national database. SUBJECTS AND METHODS: The Kids' Inpatient Database was systematically searched to extract patients under 19 years old admitted with a diagnosis of epiglottitis and undergoing an airway intervention. RESULTS: Three hundred forty-two sampled admissions were for epiglottitis; 40 of these patients were under the age of 19 and had an airway intervention (intubation or tracheotomy). On average, patients were 4.3 years old (SD = 6.0 years). The average length of stay was 15.6 days (SD = 33.9 and range = 0-199) with average total charges of $74,931 (SD = $163,387, range - $3342-$938,5 12). Multivariate analysis revealed that admission to a children's facility, admission other than via the emergency room, and nonemergent admission were associated with increased total charges. Twenty-two states reported an admission for pediatric epiglottitis that required airway intervention. CONCLUSIONS: in our sample, only 40 patients were identified who were under the age of 19 years and required an airway intervention for the treatment of epiglottitis. Epiglottitis is a rare. expensive, and protracted disease to treat in the postvaccine era. The unique nature of this disease has implications for training future surgeons on proper management of this potentially fatal disease. C1 [Acevedo, Jason L.] Natl Capital Consortium, Dept Otolaryngol Head & Neck Surg, Omaha, NE USA. [Lander, Lina] Univ Nebraska, Med Ctr, Dept Epidemiol, Omaha, NE USA. [Choi, Sukgi; Shah, Rahul K.] George Washington Univ, Childrens Natl Med Ctr, Div Otolaryngol, Washington, DC 20052 USA. RP Acevedo, JL (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave, Washington, DC 20307 USA. EM jasag00@yahoo.com NR 9 TC 5 Z9 5 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 2009 VL 140 IS 4 BP 548 EP 551 DI 10.1016/j.otohns.2008.12.037 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 425FP UT WOS:000264622700018 PM 19328345 ER PT J AU Gentlesk, PJ Sauer, WH Peele, ME Eckart, RE AF Gentlesk, Philip J. Sauer, William H. Peele, Mark E. Eckart, Robert E. TI Untitled Response SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY LA English DT Letter C1 [Gentlesk, Philip J.; Sauer, William H.; Peele, Mark E.; Eckart, Robert E.] Brooke Army Med Ctr, Serv Cardiol, Ft Sam Houston, TX 78234 USA. RP Gentlesk, PJ (reprint author), Brooke Army Med Ctr, Serv Cardiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0147-8389 J9 PACE JI PACE-Pacing Clin. Electrophysiol. PD APR PY 2009 VL 32 IS 4 BP 563 EP 563 PG 1 WC Cardiac & Cardiovascular Systems; Engineering, Biomedical SC Cardiovascular System & Cardiology; Engineering GA 424GF UT WOS:000264552800025 ER PT J AU Veerappan, GR Cash, BD AF Veerappan, Ganesh R. Cash, Brooks D. TI Should computed tomographic colonography replace optical colonoscopy in screening for colorectal cancer? SO POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE LA English DT Review DE colorectal cancer (CRC); colonoscopy; computed tomographic colonography (CTC); screening; virtual colonoscopy ID VIRTUAL COLONOSCOPY; CT COLONOGRAPHY; TASK-FORCE; SURVEILLANCE; GUIDELINES; NEOPLASIA; ADENOMAS; SOCIETY; DEMAND; POLYPS AB Clinical evidence amassed over the last several decades indicates that routine colorectal cancer (CRC) screening, compared to no screening, detects CRC at an earlier stage, reduces the incidence of CRC or the progression early CRC through polypectomy, and reduces CRC mortality. Computed tomographic colonography (CTC) is a minimally invasive, structural evaluation of the entire colorectum that has recently been advocated by multiple American professional medical societies as an effective alternative for CRC screening. The potential advantages of CTC, including rapid image acquisition and processing, non-invasiveness, and decreased procedural risks of perforation, bleeding, and sedation complications may serve to improve the low rates of colorectal cancer screening that are currently observed in our society. Several large studies of CTC as a CRC screening test have reported excellent results but have been criticized because of the expertise of CTC interpreters participating in those trials. As a response to these criticisms, the long-awaited results of the American College of Radiology Imaging Network (ACRIN) National CT Colonography Trial were recently published. The purpose of this study was to assess the accuracy of CTC in a "community based" environment to determine if previous results obtained at expert sites could be replicated. All CTC were confirmed and compared to conventional colonoscopy, the gold-standard colorectal cancer screening test. For polyps >10 mm, the results obtained in the ACRIN trial were comparable to previous studies with a mean CTC sensitivity of 90% and a mean CTC specificity of 86%. The sensitivity of CTC fell to 78% for lesions >6 mm, a value that some studies have suggested is comparable to the detection rate of conventional colonoscopy. This study adds to the body of literature regarding the efficacy of CTC and will likely be cited by many as evidence supporting CTC as an acceptable CRC screening test, in the same league as colonoscopy. Issues remain, however, regarding the extension and reproducibility of these results in the true community setting. There are concerns regarding thresholds for referrals, appropriate intervals between studies, the optimal management of extracolonic findings, and radiation exposure with CTC that remain unanswered by these data. C1 [Veerappan, Ganesh R.; Cash, Brooks D.] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. [Cash, Brooks D.] Natl Naval Med Ctr, Dept Gastroenterol, Bethesda, MD USA. RP Cash, BD (reprint author), Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. EM brooks.cash@med.navy.mil NR 22 TC 4 Z9 4 U1 0 U2 1 PU MEDYCYNA PRAKTYCZNA PI KRAKOW PA UL KRAKOWSKA 41, KRAKOW, 31-066, POLAND SN 0032-3772 J9 POL ARCH MED WEWN JI Pol. Arch. Med. Wewn. PD APR PY 2009 VL 119 IS 4 BP 236 EP 240 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 478NT UT WOS:000268595700009 PM 19413183 ER PT J AU Grujicic, M He, T Pandurangan, B Bell, WC Cheeseman, BA Roy, WN Skaggs, RR AF Grujicic, M. He, T. Pandurangan, B. Bell, W. C. Cheeseman, B. A. Roy, W. N. Skaggs, R. R. TI Development, parameterization, and validation of a visco-plastic material model for sand with different levels of water saturation SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS LA English DT Article DE sand; material model; saturation level; blast loading; tire-soil interactions ID HIGH-STRAIN-RATE; CAP MODEL; SOILS; DEFORMATION AB A new material model for sand has been developed in order to include the effects of the deformation rate and the degree of saturation on the constitutive response of this material. The model is an extension of the original high strain-rate compaction model for sand developed by Laine and Sandvik and an elastic-visco-plastic material model for sand recently proposed by Tong and Tuan in which these effects were neglected. The new material model was parameterized using the available experimental data for sand with different levels of saturation tested mechanically at different strain rates. The model is next used, within a non-linear-dynamics transient computational analysis, to study: (a) various phenomena associated with the explosion of shallow-buried and ground-laid mines and (b) the dynamic behaviour of a vehicle during an off-road ride. The computational results are then compared with the corresponding experimental results. This comparison suggested that the newly developed material model for sand captures the essential features of the dynamic behaviour of sand with different levels of saturation when subjected to realistic high and low strain-rate loading conditions. C1 [Grujicic, M.; He, T.; Pandurangan, B.; Bell, W. C.] Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.; Roy, W. N.; Skaggs, R. R.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica@ces.clemson.edu FU US Army/CU Cooperative [W911NF-04-2-0024, W911NF-062-0042]; US Army [DAAD19-01-1-0661]; ARC-TARDEC FX The material presented in this article is based on work supported by the US Army/CU Cooperative Agreements W911NF-04-2-0024 and W911NF-062-0042 and by the US Army Grant Number DAAD19-01-1-0661, and by an ARC-TARDEC research contract. NR 42 TC 5 Z9 5 U1 1 U2 2 PU PROFESSIONAL ENGINEERING PUBLISHING LTD PI WESTMINISTER PA 1 BIRDCAGE WALK, WESTMINISTER SW1H 9JJ, ENGLAND SN 1464-4207 J9 P I MECH ENG L-J MAT JI Proc. Inst. Mech. Eng. Pt. L-J. Mater.-Design Appl. PD APR PY 2009 VL 223 IS L2 BP 63 EP 81 DI 10.1243/14644207JMDA237 PG 19 WC Materials Science, Multidisciplinary SC Materials Science GA 455ED UT WOS:000266739400002 ER PT J AU Riggs, JE Hobbs, GR Riggs, TH AF Riggs, Jack E. Hobbs, Gerald R. Riggs, Todd H. TI Electoral College Winner's Advantage SO PS-POLITICAL SCIENCE & POLITICS LA English DT Article ID BIAS; STATES; LOCK AB Compared to the popular vote, the Electoral College magnifies the perception of the winner's margin of victory. In this analysis, a method of quantifying the magnitude of the advantage given to the winner due to the Electoral College's two electoral vote add-on and winner-take-all methodologies is presented. Using the electoral vote distribution that was present in the 2000 U.S. presidential. election, we analyzed one million random two-candidate simulated elections. The results show that the net effect of the Electoral College is to give the winning candidate an average 29.45 electoral vote advantage per election due to the winner-take-all methodology. This winner's advantage includes an average 0.42 electoral vote advantage given to the winner per election due to the two electoral vote add-on. C1 [Riggs, Jack E.; Hobbs, Gerald R.] W Virginia Univ, Morgantown, WV 26506 USA. [Riggs, Todd H.] US Mil Acad, West Point, PA USA. RP Riggs, JE (reprint author), W Virginia Univ, Morgantown, WV 26506 USA. NR 11 TC 2 Z9 2 U1 1 U2 6 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1049-0965 J9 PS-POLIT SCI POLIT JI PS-Polit. Sci. Polit. PD APR PY 2009 VL 42 IS 2 BP 353 EP 357 DI 10.1017/S1049096509090465 PG 5 WC Political Science SC Government & Law GA 434NI UT WOS:000265281000016 ER PT J AU Huzella, LM Buckley, MJ Alves, DA Stiles, BG Krakauer, T AF Huzella, Louis M. Buckley, Marilyn J. Alves, Derron A. Stiles, Bradley G. Krakauer, Teresa TI Central roles for IL-2 and MCP-1 following intranasal exposure to SEB: A new mouse model SO RESEARCH IN VETERINARY SCIENCE LA English DT Article DE Chemokines; Cytokines; Mouse model; Staphylococcal enterotoxin B (SEB); Temperature ID STAPHYLOCOCCAL-ENTEROTOXIN-B; VASCULAR LEAK SYNDROME; INDUCED TOXIC-SHOCK; TRANSGENIC MICE; AIRWAY INFLAMMATION; CYTOKINE RELEASE; PROTECTS MICE; LETHAL SHOCK; MURINE MODEL; LIPOPOLYSACCHARIDE AB Murine models for bacterial superantigens like staphylococcal enterotoxin B (SEB) have to date been rather cumbersome. The reasons include: (1) necessary use of potentiating agents such as actinomycin D, D-galactosamine, lipopolysaccharide (LPS), or viruses: (2) high toxin amounts required to elicit effects; and/or (3) generation of phenotypic-stable transgenic animals. Our study employed readily available C3H/HeJ (TLR4 negative, LPS-nonresponsive) mice with intranasal and intraperitoneal administration of low microgram quantities of SEB. These animals responded to SEB with severe lung inflammation and hypothermia, culminating in death. A survey of cytokines/chemokines in sera and lungs after lethal intoxication revealed that monocyte chemoattractant protein-1 and interleukin-2 were associated with effects in this model. In contrast, SEB had minimal effects upon congenic (TLR4 positive, LPS-responsive) C3H/OuJ mice. Lethality of SEB in C3H/HeJ mice was neutralized with SEB-specific antibodies, suggesting potential utility of this model for future therapeutic studies. (c) Published by Elsevier Ltd. C1 [Buckley, Marilyn J.; Stiles, Bradley G.; Krakauer, Teresa] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Huzella, Louis M.; Alves, Derron A.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Krakauer, T (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM teresa.krakauer@amedd.army.mil FU Defense Threat Reduction Agency [3.10035] FX The research described herein was sponsored by the Defense Threat Reduction Agency (Plan 3.10035). The opinions, interpretations, as well as conclusions represent those of the authors and are not necessarily endorsed by the Department of Defense. NR 40 TC 22 Z9 23 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0034-5288 J9 RES VET SCI JI Res. Vet. Sci. PD APR PY 2009 VL 86 IS 2 BP 241 EP 247 DI 10.1016/j.rvsc.2008.07.020 PG 7 WC Veterinary Sciences SC Veterinary Sciences GA 419UI UT WOS:000264244800010 PM 18793785 ER PT J AU Sterner, JB Morris, MJ Sill, JM Hayes, JA AF Sterner, James B. Morris, Michael J. Sill, Joshua M. Hayes, Jackie A. TI Inspiratory Flow-Volume Curve Evaluation for Detecting Upper Airway Disease SO RESPIRATORY CARE LA English DT Article DE inspiratory curve; upper airway obstruction; pulmonary function testing ID VOCAL-CORD DYSFUNCTION; OBSTRUCTING LESIONS; PULMONARY-FUNCTION; LOOPS; MANAGEMENT; DIAGNOSIS; FEATURES; TRACHEA; LARYNX AB BACKGROUND: The 2005 American Thoracic Society/European Respiratory Society guidelines on spirometry emphasize examination of the inspiratory curve of the flow-volume loop for evidence of intrathoracic or extrathoracic upper airway obstruction. We sought to determine how frequently evaluations are performed for abnormal inspiratory curves. METHODS: We retrospectively reviewed all examinations performed in our pulmonary function testing laboratory over a 12-month period (n = 2,662). In patients with normal spirometry or a mild restrictive defect, we inspected the inspiratory curves for truncation, flattening, or absent loop. With patients who had an abnormal inspiratory curve, we examined 3 flow-volume loops to determine if more than one loop showed an inspiratory abnormality, and to assess changes in the mid-flow ratio (ratio of forced expiratory flow at 50% of the forced expiratory volume to forced inspiratory flow at 50% of the forced inspiratory volume), and we used the loop that had the best inspiratory and expiratory curves. We reviewed the medical records for underlying disease processes and evidence of upper airway evaluation. RESULTS: One hundred twenty-three patients (4.6%) had an abnormal inspiratory curve. Sixty-nine (56%) of those 123 patients had inspiratory abnormalities on > 2 flow-volume loops. Evaluation of the inspiratory abnormality was undertaken in only 1.7% of all patients, and 30% of patients who had consistently abnormal inspiratory curves. A specific etiology was identified in 52% of the evaluated patients. Vocal cord dysfunction was the most frequent diagnosis. Utilizing the loop that had the combination of the best inspiratory and expiratory curves decreased the mid-flow ratio from 3.07 +/- 1.63 to 1.77 +/- 1.15. CONCLUSIONS: An abnormal inspiratory curve in the presence of otherwise normal spirometry should prompt an evaluation for the etiology. If one of the flow-volume inspiratory curves shows an abnormality, all the inspiratory curves from that PFT session should be reviewed, and if more than one inspiratory curves is abnormal, both anatomical and functional evaluation should be undertaken for intrathoracic and extrathoracic upper airway obstruction. C1 [Sterner, James B.; Morris, Michael J.; Sill, Joshua M.; Hayes, Jackie A.] Brooke Army Med Ctr, Dept Med, Pulm Dis Crit Care Serv, Ft Sam Houston, TX 78234 USA. RP Morris, MJ (reprint author), Brooke Army Med Ctr, Dept Med, Pulm Dis Crit Care Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM michael.morris@amedd.army.mil NR 30 TC 34 Z9 34 U1 3 U2 5 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD APR PY 2009 VL 54 IS 4 BP 461 EP 466 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 431PL UT WOS:000265075000006 PM 19327180 ER PT J AU Watson, MA King, CS Holley, AB Greenburg, DL Mikita, JA AF Watson, Maura A. King, Christopher S. Holley, Aaron B. Greenburg, David L. Mikita, Jeffrey A. TI Clinical and Lung-Function Variables Associated With Vocal Cord Dysfunction SO RESPIRATORY CARE LA English DT Article DE vocal cord dysfunction; paradoxical vocal cord motion; flow-volume loop; spirometry; laryngoscopy ID EXERCISE-INDUCED ASTHMA; EXERTIONAL DYSPNEA; CHILDREN; PATIENT; OBESITY; UTILITY; AIRWAY AB BACKGROUND: Vocal cord dysfunction (VCD) is difficult to diagnose. Laryngoscopy while the patient is symptomatic is the accepted standard method to establish a diagnosis of VCD, but patient characteristics and spirometry values are thought to be useful for predicting VCD. We sought to identify clinical and spirometric variables that suggest VCD. METHODS: We performed 2 parallel studies. First, 3 staff pulmonologists (who were blinded to the laryngoscopy results), scored 3 flow-volume loops from each PFT session on the likelihood that the inspiratory curve indicated VCD. We also performed a cross-sectional study of clinical characteristics and spirometric data from all patients who underwent laryngoscopy for any indication, including suspected VCD, over a 3-year period. We compared the laryngoscopy findings to the clinical characteristics, spirometry results, and the pulmonologists' assessments of the flow-volume loops. We used multivariate logistic regression to identify independent predictors of VCD. RESULTS: The pulmonologists agreed about which flow-volume loops predicted VCD (quadratic kappa range 0.55-0.76), but those ratings were not predictive of laryngoscopic diagnosis of VCD. During the study period, 226 patients underwent laryngoscopy. One hundred (44%) were diagnosed with VCD. Independent predictors of VCD included female sex (odds ratio 2.72, 95% confidence interval 1.55-4.75) and obesity (body mass index > 30 kg/m(2)) (odds ratio 2.06, 95 % confidence interval 1.12-3.80). With spirometric data from the effort that had the best forced-vital-capacity, multivariate analysis found the ratio of the forced inspiratory flow at 25% of the inspired volume to forced inspiratory flow at 75% of the inspired volume (FIF25%/75%) predictive of VCD (odds ratio 1.97, 95% confidence interval 1.12-3.44). The diagnostic performance of these characteristics was poor; the area under the receiver-operating-characteristic curve was 0.68. With the spirometric data from the effort that had the subjectively determined best inspiratory curve, and after controlling for the reproducibility of the inspiratory curves, multivariate analysis found none of the spirometric variables predictive of VCD. CONCLUSIONS: VCD remains difficult to predict with spirometry or flow-volume loops. If VCD is suspected, normal flow-volume loop patterns should not influence the decision to perform laryngoscopy. C1 [Watson, Maura A.; King, Christopher S.; Holley, Aaron B.; Greenburg, David L.; Mikita, Jeffrey A.] Walter Reed Army Med Ctr, Washington, DC 20016 USA. RP King, CS (reprint author), Walter Reed Army Med Ctr, 3831 Rodman St NW,F30, Washington, DC 20016 USA. EM christopher.king@amedd.army.mil NR 26 TC 28 Z9 28 U1 0 U2 2 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD APR PY 2009 VL 54 IS 4 BP 467 EP 473 PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 431PL UT WOS:000265075000007 PM 19327181 ER PT J AU Clausen, JL Korte, N AF Clausen, Jay L. Korte, Nic TI Environmental fate of tungsten from military use SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Tungsten; Soil; Groundwater; Contamination ID TRACE-METALS; ADSORPTION; SORPTION; CUP AB This manuscript describes the distribution, fate and transport of tungsten used in training rounds at three small arms ranges at Camp Edwards on the Massachusetts Military Reservation (MMR), USA. Practice with tungsten/nylon rounds began in 2000 subsequent to a 1997 US Environmental Protection Agency ban on training with lead. Training with the tungsten rounds was halted in 2005 because of concerns regarding tungsten's environmental mobility and potential toxicity. This study, therefore, examines how tungsten partitions in the environment when fired on a small arms training range. Soil sampling revealed surface soil concentrations, highest at the berm face, up to 2080 mg/kg. Concentrations decreased rapidly with depth-at least by an order of magnitude by 25 cm. Nonetheless, tungsten concentrations remained above background to at least 150 cm. Pore-water samples from lysimeters installed in berm areas revealed a range of concentrations (<1-400 mg/L) elevated with respect to background although there was no discernable trend with depth. Groundwater monitoring well samples collected approximately 30 m below ground surface showed tungsten (0.001-0.56 mg/L) attributable to range use. Published by Elsevier B.V. C1 [Clausen, Jay L.] USA, Cold Reg Res & Engn Lab, Ctr Res & Dev, Hanover, NH 03755 USA. RP Clausen, JL (reprint author), USA, Cold Reg Res & Engn Lab, Ctr Res & Dev, 72 Lyme Rd, Hanover, NH 03755 USA. EM Jay.LClausen@erdc.usace.army.mil FU US Army Environmental Center (USAEC) FX This work was funded by the US Army Environmental Center (USAEC). NR 28 TC 18 Z9 20 U1 3 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD APR 1 PY 2009 VL 407 IS 8 BP 2887 EP 2893 DI 10.1016/j.scitotenv.2009.01.029 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 429LN UT WOS:000264922000044 PM 19217645 ER PT J AU Gibson, S Abraham, D Heath, R Schoellhamer, D AF Gibson, Stanford Abraham, David Heath, Ronald Schoellhamer, David TI Vertical gradational variability of fines deposited in a gravel framework SO SEDIMENTOLOGY LA English DT Article DE Depth fining; flume experiments; gravel clogging; hyporheic conductivity; interstitial deposits; siltation; vertical sorting ID DAM REMOVAL; GRANULAR FILTERS; LABORATORY FLUME; STREAM; SEDIMENT; BED; TRANSPORT; EXCHANGE; RIVER; COMMUNITIES AB Vertical gradational structures develop as sand infiltrates into static gravel beds. Understanding the vertical distribution of interstitial sand deposits will improve predictions of ecological suitability and hyporheic hydrodynamics. A series of flume experiments was performed to investigate fine infiltration processes. Four sand distributions were introduced into flows over gravel beds. After each experiment, bed cores were extracted and analysed in vertical layers to examine the gradational trends with depth. Vertical trends of fine content were highly sensitive to the relative grain-size distributions of the gravel bed and the introduced sand. For experiments with d(15gravel)/d(85sand) ratios 15.4 and larger unimpeded static percolation was observed, where sand filled the voids relatively uniformly from the bottom of the gravel layer to the top. Experiments with ratios 10.6 and smaller bridged. Sand clogged a thin layer of gravel pores near the bed surface, precluding subsequent infiltration. Interstitial sand deposits fined with depth of penetration for all experiments which was the result of three distinct but overlapping processes. (i) Granular sorting: As particles fell through the substrate, smaller material preferentially passed through the voids deeper into the gravel. (ii) Bed-load sorting: Size segregation occurs in the wake of the leading bed form as smaller particles saltate further and settle first. (iii) Hydraulic sorting: Smaller sand was transported preferentially as suspended load filling the deep voids of the furthest flume positions downstream. Finally, when the experiments that formed a bridge layer were replicated with higher bed shear stresses, less interstitial sand deposition was observed. Higher shear stresses transported coarse particles downstream more efficiently causing bridge layers to form earlier and allowing less time for suspended load to settle into the deeper substrate pores before the pathways were closed. C1 [Gibson, Stanford] USA, Corps Engineers, Hydrol Engn Ctr, Davis, CA USA. [Gibson, Stanford; Schoellhamer, David] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. [Abraham, David; Heath, Ronald] USA, Corps Engineers, Coastal & Hydraul Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Gibson, S (reprint author), USA, Corps Engineers, Hydrol Engn Ctr, Davis, CA USA. EM stanford.gibson@usace.army.mil FU U.S. Army Corps of Engineers' System-Wide Water Resources Program FX This work was funded through the U.S. Army Corps of Engineers' System-Wide Water Resources Program. The sand hopper used was loaned to the CHL by the Agricultural Research Station National Sediment Laboratory of the U.S. Department of Agriculture. Bill Katzenmeyer assisted with flume maintenance and experimental set-up. Detailed reviews by Stephen Rice, Paul Carling, Maarten G. Kleinhans, Lynne Frostick, Panayiotis Diplas, John Hickey and one anonymous reviewer provided many helpful comments that greatly improved this manuscript as well as the conclusions of the study. NR 74 TC 20 Z9 20 U1 1 U2 16 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0037-0746 J9 SEDIMENTOLOGY JI Sedimentology PD APR PY 2009 VL 56 IS 3 BP 661 EP 676 DI 10.1111/j.1365-3091.2008.00991.x PG 16 WC Geology SC Geology GA 416TT UT WOS:000264029100004 ER PT J AU Moawad, FJ Goldkind, L AF Moawad, Fouad J. Goldkind, Lawrence TI An Unusual Case of Colonic Ischemia SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE estrogen; irritable bowel syndrome; ischemic colitis; migraines; sumatriptan ID ORAL-CONTRACEPTIVE USE; COLITIS AB Sumatriptan is widely prescribed for the treatment of migraine headaches. Its actions are mediated via agonist action oil the vascular 5-hydroxytryptamine 1 receptor which results in vasoconstriction. We report a case of a 46-year-old woman who developed ischemic colitis while taking increasing doses of sumatriptan for a-migraine headache. Her only other medication was oral contraceptives. Interestingly, a potential synergistic action between the two medications may exist since estrogen reduces triptan clearance through its action on monamine oxide, ail enzyme that metabolizes serotonin. Sumatriptan should be recognized as an important cause of drug-induced colonic ischemia, especially in patients taking estrogen. C1 [Moawad, Fouad J.] Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, Washington, DC 20307 USA. Natl Naval Med Ctr, Gastroenterol Serv, Bethesda, MD USA. RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, 6900 Georgia Ave, Washington, DC 20307 USA. EM fouad.moawad@amedd.army.mil NR 8 TC 8 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD APR PY 2009 VL 102 IS 4 BP 405 EP 407 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 432XI UT WOS:000265167300015 PM 19279546 ER PT J AU Minami, NA Madnick, S AF Minami, Nathan A. Madnick, Stuart TI Dynamic analysis of combat vehicle accidents SO SYSTEM DYNAMICS REVIEW LA English DT Article ID STRESS; SLEEP; QUALITY; FATIGUE; HAZARD AB To the chagrin of well-intentioned Army leaders, dozens of soldiers are killed each Year as it result of combat vehicle accidents. The objective of this study is to look beyond the events and symptoms of accidents which normally indicate human error. and instead study the upper-level organizational processes and problems that constitute the actual root causes of accidents. After a short review of the literature we report Oil our development of a system dynamics model. We then discuss the results of several simulations: these suggest that high-level decisions that balance mission rate and operations tempo with troop availability, careful management of the work-rest cycle for deployed troops. and improvement of the processes for evaluating the lessons learned from accidents would lead to a reduction in Army combat vehicle accidents. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 [Minami, Nathan A.] US Mil Acad, Dept Syst Engn, West Point, NY 10997 USA. [Madnick, Stuart] MIT, Alfred P Sloan Sch Management, Cambridge, MA 02139 USA. [Madnick, Stuart] MIT, Sch Engn, Cambridge, MA 02139 USA. RP Minami, NA (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10997 USA. EM Nathan.minami@us.army.mil RI Madnick, Stuart/A-8465-2011 NR 32 TC 6 Z9 6 U1 0 U2 8 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0883-7066 J9 SYST DYNAM REV JI Syst. Dyn. Rev. PD APR-JUN PY 2009 VL 25 IS 2 BP 79 EP 100 DI 10.1002/sdr.415 PG 22 WC Management; Social Sciences, Mathematical Methods SC Business & Economics; Mathematical Methods In Social Sciences GA 454GT UT WOS:000266671100001 ER PT J AU Rogers, CJ AF Rogers, Clifford J. TI The Battle of Hastings, 1066 SO WAR IN HISTORY LA English DT Book Review C1 [Rogers, Clifford J.] US Mil Acad, West Point, NY 10996 USA. RP Rogers, CJ (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 2 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-3445 J9 WAR HIST JI War Hist. PD APR PY 2009 VL 16 IS 2 BP 239 EP 240 DI 10.1177/0968344508100991 PG 2 WC History; International Relations SC History; International Relations GA 424FP UT WOS:000264551200005 ER PT J AU Miao, GW Himayat, N Li, Y Swami, A AF Miao, Guowang Himayat, Nageen Li, Ye (Geoffrey) Swami, Ananthram TI Cross-layer optimization for energy-efficient wireless communications: a survey SO WIRELESS COMMUNICATIONS & MOBILE COMPUTING LA English DT Article DE energy efficiency; cross-layer; wireless communications; energy aware ID SENSOR NETWORKS; SPECTRAL EFFICIENCY; DESIGN; TRANSMISSION; CHALLENGES; MANAGEMENT; LINK AB Since battery technology has not progressed as rapidly as semiconductor technology, power efficiency has become increasingly important in wireless networking, in addition to the traditional quality and performance measures, such as bandwidth, throughput, and fairness. Energy-efficient design requires a cross layer approach as power consumption is affected by all aspects of system design, ranging from silicon to applications. This article presents a comprehensive overview of recent advances in cross-layer design for energy-efficient wireless communications. We particularly focus on a system-based approaches toward energy optimal transmission and resource management across time, frequency, and spatial domains. Details related to energy-efficient hardware implementations are also covered. Copyright (C) 2008 John Wiley & Sons, Ltd. C1 [Miao, Guowang; Li, Ye (Geoffrey)] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. [Himayat, Nageen] Intel Corp, Commun Technol Lab, Santa Clara, CA 95051 USA. [Swami, Ananthram] USA, Res Lab, CISD, Washington, DC USA. RP Miao, GW (reprint author), Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA. EM gmiao3@gatech.edu FU Intel Corp.; U.S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement [DAAD 19-01-20-0011] FX This work was supported by Intel Corp. and the U.S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD 19-01-20-0011. NR 73 TC 187 Z9 195 U1 1 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1530-8669 EI 1530-8677 J9 WIREL COMMUN MOB COM JI Wirel. Commun. Mob. Comput. PD APR PY 2009 VL 9 IS 4 SI SI BP 529 EP 542 DI 10.1002/wcm.698 PG 14 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 433ZF UT WOS:000265243700007 ER PT J AU Massa, J Munger, KL O'Reilly, EJ Levin, LI Ascherio, A AF Massa, J. Munger, K. L. O'Reilly, E. J. Levin, L. I. Ascherio, A. TI Serum titers of IgG antibodies against tetanus and diphtheria toxoids and risk of multiple sclerosis SO JOURNAL OF NEUROIMMUNOLOGY LA English DT Article DE Multiple sclerosis; Tetanus; Diphtheria; Etiology; Prospective studies; IgG Antibodies AB We conducted a prospective nested case-control study among military service members to investigate whether antibodies against tetanus or diphtheria predict multiple sclerosis (MS) risk. Paired T-tests were used to compare means of anti-tetanus and diphtheria toxoids among 56 MS cases and 112 matched controls. Conditional logistic regression was used to estimate odds ratios (OR). There were no differences between the mean serum IgG antibodies against tetanus (p-value 0.28) or diphtheria (p-value 0.45) in the baseline samples. The OR of MS associated with I standard deviation difference in antibody titers was 0.76 (95% CI: 0.48-1.21) for tetanus (SD=4.71) and 1.03 (0.73-1.45) for diphtheria (SD=0.87). Results of this study suggest serum IgG antibodies against tetanus or diphtheria are not predictors of MS risk. (C) 2009 Elsevier B.V. All rights reserved. C1 [Massa, J.; Munger, K. L.; O'Reilly, E. J.; Ascherio, A.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Massa, J.; O'Reilly, E. J.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Levin, L. I.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Ascherio, A.] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA. [Ascherio, A.] Harvard Univ, Sch Med, Boston, MA USA. RP Massa, J (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA. EM jmassa@hsph.harvard.edu FU National Institutes of Health [R01 NS042194] FX The project described was supported by Grant Number R01 NS042194 from the National Institutes of Health. NR 7 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-5728 J9 J NEUROIMMUNOL JI J. Neuroimmunol. PD MAR 31 PY 2009 VL 208 IS 1-2 BP 141 EP 142 DI 10.1016/j.jneuroim.2009.01.006 PG 2 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 435QJ UT WOS:000265358100019 PM 19201486 ER PT J AU Shostakovich-Koretskaya, L Catano, G Chykarenko, ZA He, W Gornalusse, G Mummidi, S Sanchez, R Dolan, MJ Ahuja, SS Clark, RA Kulkarni, H Ahuja, SK AF Shostakovich-Koretskaya, Ludmila Catano, Gabriel Chykarenko, Zoya A. He, Weijing Gornalusse, German Mummidi, Srinivas Sanchez, Racquel Dolan, Matthew J. Ahuja, Seema S. Clark, Robert A. Kulkarni, Hemant Ahuja, Sunil K. TI Combinatorial content of CCL3L and CCL4L gene copy numbers influence HIV-AIDS susceptibility in Ukrainian children SO AIDS LA English DT Article DE AIDS; CCL3L; CCL4L; HIV; transmission ID NON-ALLELIC VARIANT; IMMUNODEFICIENCY-VIRUS; SEGMENTAL DUPLICATIONS; ANTI-HIV-1 ACTIVITY; CHEMOKINE GENES; HUMAN GENOME; VIRAL ENTRY; INFECTION; CCR5; TRANSMISSION AB Objective: CCL3L and CCL4L genes encode HIV-suppressive chemokines, colocalize on chromosome 17q12 and have copy number variation. Copy number variation of CCL3L associates with HIV-AIDS susceptibility. Here, we determined the influence of the combinatorial content of distinct CCL3L and CCL4L genes on HIV-AIDS susceptibility. Methods: By designing gene-specific assays, the association between closes of all CCL3L or CCL4L genes or their individual duplicated components (CCL3La/b and CCL4La/b) with HIV-AIDS susceptibility was determined in 298 perinatally exposed Ukrainian children. Results: The odds of transmission was increased in children with less than two copies of CCL3L or CCL4L, compared with those with at least two copies, and 10-fold higher when both mother and offspring had less than two CCL3L or CCL4L copies, compared with mother-child pairs with at least two copies. The extent of the pair-wise correlations between CCL3La, CCL3Lb, CCL4La and CCL4Lb copy number varied extensively, with an inverse correlation between CCL4L genes that transcribe a classical chemokine (CCL4La) versus aberrantly-spliced transcripts (CCL4Lb). Children possessing only CCL4Lb progressed four times faster to AIDS than those with only CCL4La. A lower content of CCL3L and CCL4L genes that transcribe classical chemokines was associated with enhanced HIV-AIDS susceptibility. Conclusion: Transmission risk is greatest when mother and offspring both have low CCL3L or CCL4L gene doses. The impact on HIV-AIDS susceptibility of the chemokine gene-rich locus on 17q12 is dependent on the balance between the doses of genes conferring protective (CCL3La and CCL4La) versus detrimental (CCL4Lb) effects. Hence, the combinatorial genomic content of distinct genes within a copy number variable region may determine disease susceptibility. (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Vet Adm HIV AIDS Ctr, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA. [Shostakovich-Koretskaya, Ludmila; Chykarenko, Zoya A.] Dnepropetrovsk State Med Acad, Dept Gen Pediat & Pediat Infect Dis, Dnepropetrovsk, Ukraine. [Catano, Gabriel; He, Weijing; Gornalusse, German; Mummidi, Srinivas; Sanchez, Racquel; Ahuja, Seema S.; Clark, Robert A.; Kulkarni, Hemant; Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr, Vet Adm Res Ctr AIDS & HIV Infect 1, Ft Sam Houston, TX USA. [Catano, Gabriel; He, Weijing; Gornalusse, German; Mummidi, Srinivas; Sanchez, Racquel; Ahuja, Seema S.; Clark, Robert A.; Kulkarni, Hemant; Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr, Dept Med, Ft Sam Houston, TX USA. [Dolan, Matthew J.] Brooke Army Med Ctr, SAMMC, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Dolan, Matthew J.] Wilford Hall USAF Med Ctr, Henry M Jackson Fdn, Lackland AFB, TX 78236 USA. RP Ahuja, SK (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Vet Adm HIV AIDS Ctr, Dept Microbiol & Immunol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM ahujas@uthscsa.edu RI Mummidi, Srinivas/C-1004-2008 OI Mummidi, Srinivas/0000-0002-4068-6380 FU U.S. Civilian Research and Development (CRDF) [UKB2-2705-DP-05]; NIH [R37046326]; Elizabeth Glaser Scientist Award; Burroughs Wellcome Clinical Scientist Award FX Supported by award no. UKB2-2705-DP-05 of the U.S. Civilian Research and Development (CRDF) to L.S.K. and S.K.A., the Veterans Administration Center on AIDS and HIV infection at the South Texas Veterans Healthcare System and a MERIT award (R37046326) from the NIH to S.K.A. This work was also supported by a Elizabeth Glaser Scientist Award and Burroughs Wellcome Clinical Scientist Award in Translational Research to S.K.A. NR 41 TC 30 Z9 31 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD MAR 27 PY 2009 VL 23 IS 6 BP 679 EP 688 DI 10.1097/QAD.0b013e3283270b3f PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 429VT UT WOS:000264948900005 PM 19279442 ER PT J AU Lyke, KE Daou, M Diarra, I Kone, A Kouriba, B Thera, MA Dutta, S Lanar, DE Heppner, DG Doumbo, OK Plowe, CV Sztein, MB AF Lyke, Kirsten E. Daou, Modibo Diarra, Issa Kone, Abdoulaye Kouriba, Bourema Thera, Mohamadou A. Dutta, Sheetij Lanar, David E. Heppner, D. Gray, Jr. Doumbo, Ogobara K. Plowe, Christopher V. Sztein, Marcelo B. TI Cell-mediated immunity elicited by the blood stage malaria vaccine apical membrane antigen 1 in Malian adults: Results of a Phase I randomized trial SO VACCINE LA English DT Article DE Malaria; Vaccine; Cell-mediated immunity; Plasmodium falciparum ID PLASMODIUM-FALCIPARUM MALARIA; CLINICAL-TRIAL; PRECLINICAL EVALUATION; PROTECTIVE IMMUNITY; ANTIBODY-RESPONSE; CANDIDATE; AMA-1; IMMUNOGENICITY; VOLUNTEERS; INVASION AB The development of a safe and effective malaria vaccine is impeded by the complexity of the Plasmodium life cycle. A vaccine that elicits both cell-mediated and humoral immune responses might be needed for protection against this multistage parasitic infection. Apical membrane antigen 1 (AMA-1) plays a key role in erythrocytic invasion but is also expressed in sporozoites and in late stage liver schizonts, where it may provide a target of protective cell-mediated immunity (CMI). A Phase 1 trial of a vaccine consisting of recombinant AMA-1 protein and the Adjuvant system AS02A was conducted in 60 Malian adults aged 18-55 years who were randomized to receive either half dose (25 mu g/0.25 ml) or full dose (50 mu g/0.5 ml) FMP2.1/AS02A or a control rabies vaccine. Interleukin 5 (IL-5) and interferon-gamma (IFN-gamma) production as evaluated by ELISpot and lymphocyte proliferation were measured after in vitro AMA-1 stimulation of peripheral blood mononuclear cells (PBMCs) collected on Days 0 and 90. Post. FMP2.1/AS02A immunization mean stimulation indices were significantly elevated as were the number of IL-5 spot forming cells (SFC)/10(6) PBMC, but no difference was noted in INF-gamma production between the AMA-1/AS02A vaccinated group and the rabies group. These results provide evidence that complex immune responses can be induced by this vaccination strategy and add further impetus for the continuing clinical evaluation Of this vaccine. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Lyke, Kirsten E.; Plowe, Christopher V.; Sztein, Marcelo B.] Univ Maryland, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Daou, Modibo; Diarra, Issa; Kone, Abdoulaye; Kouriba, Bourema; Thera, Mohamadou A.; Doumbo, Ogobara K.] Univ Bamako, Bandiagara Malaria Project, Malaria Res & Training Unit, Bamako, Mali. [Dutta, Sheetij; Lanar, David E.; Heppner, D. Gray, Jr.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Lyke, KE (reprint author), 685 W Baltimore St,HSFI,Room 480, Baltimore, MD 21201 USA. EM Klyke@medicine.umaryland.edu RI Lanar, David/B-3560-2011 FU United States Agency for International Development; Military Infectious Diseases Research Program; WRAIR FX Vaccine production and laboratory assays were supported by the United States Agency for International Development, Washington, DC and by the Military Infectious Diseases Research Program, Fort Detrick, MD. The authors would like to thank the laboratory of Urszula Krzych for help in developing laboratory assay methodology, and Ms. Lisa Ware, Project Manager at WRAIR for her support. We would expressly like to acknowledge the population of Bandiagara who so graciously consented to participate in this trial and for whom we strive to develop a malaria vaccine. NR 35 TC 13 Z9 14 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 26 PY 2009 VL 27 IS 15 BP 2171 EP 2176 DI 10.1016/j.vaccine.2009.01.097 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 426AW UT WOS:000264680800013 PM 19356621 ER PT J AU BenDor, T Westervelt, J Aurambout, JP Meyer, W AF BenDor, Todd Westervelt, James Aurambout, J. P. Meyer, William TI Simulating population variation and movement within fragmented landscapes: An application to the gopher tortoise (Gopherus polyphemus) SO ECOLOGICAL MODELLING LA English DT Article DE Habitat fragmentation; Spatial dynamic model; Gopher tortoise (Gopherus polyphemus); Conservation biology; Landscape ecology; Land-use change ID HABITAT FRAGMENTATION; UNITED-STATES; HOME-RANGE; MODELS; VIABILITY; DYNAMICS; PATTERNS; PACKAGES; SPREAD; VORTEX AB As the human activity footprint grows, land-use decisions play an increasing role in determining the future of plant and animal species. Studies have shown that urban and agricultural development cannot only harm species populations directly through habitat destruction, but also by destroying the corridors that connect habitat patches and populations within a metapopulation. Without these pathways, populations can encounter inbreeding depression and degeneration, which can increase death rates and lower rates of reproduction. This article describes the development and application of the FRAGGLE model, a spatial system dynamics model designed to calculate connectivity indices among populations. FRAGGLE can help planners and managers identify the relative contribution of populations associated with habitat patches to future populations in those patches, taking into account the importance of interstitial land to migration success. The model is applied to the gopher tortoise (Gopherus polyphemus), a threatened species whose southeastern U.S. distribution has diminished significantly within its native range due to agricultural and urban development over the last several decades. This model is parameterized with life history and movement traits of the gopher tortoise in order to simulate population demographics and spatial distribution within an area in west-central Georgia that supports a significant tortoise population. The implications of this simulation modeling effort are demonstrated using simple landscape representations and a hypothetical on land-use management scenario. Our findings show that development resulting in even limited habitat losses (10%) may lead to significant increases in fragmentation as measured by a loss in the rate of dispersions (31%) among area subpopulations. (C) 2009 Elsevier B.V. All rights reserved. C1 [BenDor, Todd] Univ N Carolina, Dept City & Reg Planning, Chapel Hill, NC 27599 USA. [Westervelt, James; Meyer, William] USA, Engineer Res & Dev Ctr, CERL, Champaign, IL 61826 USA. [Aurambout, J. P.] Australian Dept Primary Ind, Parkville, Vic 3554, Australia. RP BenDor, T (reprint author), Univ N Carolina, Dept City & Reg Planning, CB 3140,New E Bldg, Chapel Hill, NC 27599 USA. EM bendor@unc.edu RI BenDor, Todd/E-1375-2016 OI BenDor, Todd/0000-0003-0132-7702 FU Land-use Evolution and Impact Assessment Model (LEAM); U.S Army Corps of Engineers; Construction Engineering Research Laboratory (CERL) FX We thank the Land-use Evolution and Impact Assessment Model (LEAM) group as well as the U.S Army Corps of Engineers, Construction Engineering Research Laboratory (CERL) for providing financial and data support and computing capacity. We also thank Jeff Terstriep and YongWook Kim for their help with computational issues. NR 59 TC 8 Z9 8 U1 9 U2 50 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD MAR 24 PY 2009 VL 220 IS 6 BP 867 EP 878 DI 10.1016/j.ecolmodel.2009.01.005 PG 12 WC Ecology SC Environmental Sciences & Ecology GA 425NS UT WOS:000264645000011 ER PT J AU Chushak, Y Stone, MO AF Chushak, Yaroslav Stone, Morley O. TI In silico selection of RNA aptamers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Chushak, Yaroslav] USA, Med Res & Mat Command, HPC Software Applicat Inst 1Biotechnol, Ft Detrick, MD 21702 USA. [Stone, Morley O.] USAF, Res Lab, Human Effectiveness Directorate, Wright Patterson AFB, OH 45433 USA. EM schushak@bioanalysis.org; morley.stone@wpafb.af.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 91-BIOL BP 431 EP 431 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857800385 ER PT J AU Amoyaw, P Ingram, C Hsu, FL Bu, XR AF Amoyaw, Prince Ingram, Conrad Hsu, Fu-Lian Bu, Xiu R. TI Chelating polymers as absorbents for removal of low concentrations of toxic heavy metals from aqueous media SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Amoyaw, Prince; Ingram, Conrad; Bu, Xiu R.] Clark Atlanta Univ, Dept Chem, Atlanta, GA 30314 USA. [Hsu, Fu-Lian] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM xbu@cau.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 187-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857807382 ER PT J AU Banks, HD AF Banks, Harold D. TI ORGN 200-Effect of substituents on the rate of azomethine ylide formation from aziridines: A computational approach SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Banks, Harold D.] USA, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM harold.banks@us.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 200-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857806068 ER PT J AU Belden, J Chambliss, CK Lotufo, GR AF Belden, Jason Chambliss, C. Kevin Lotufo, Guilherme R. TI Accumulation of trinitrotoluene (TNT) in aquatic and terrestrial invertebrates: Formation and persistence of unextractable biotransformation products SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Belden, Jason] Oklahoma State Univ, Dept Zool, Stillwater, OK 74078 USA. [Chambliss, C. Kevin] Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA. [Lotufo, Guilherme R.] ERDC USACE, Environm Lab, Vicksburg, MS 39180 USA. EM jbelden@okstate.edu; Kevin_Chambliss@baylor.edu; Guilherme.Lotufo@erdc.usace.army.mi NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 245-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804210 ER PT J AU Bennett, B AF Bennett, Brian TI Local and national chemical science career opportunities with the US government: Vital national needs of today resolved by chemists of tomorrow SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Bennett, Brian] USA, Dugway Proving Grounds, Dugway, UT 84022 USA. EM brian.bennett13@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 1205-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857802595 ER PT J AU Brochu, S Martel, R Comeau, G Nadeau, V Hewitt, AD AF Brochu, Sylvie Martel, Richard Comeau, Guillaume Nadeau, Valerie Hewitt, Alan D. TI Canadian approach to the environmental characterization and risk assessment of military training activities SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Brochu, Sylvie] Def Res Dev Canada Valcartier, Energet Mat Sect, Quebec City, PQ G3J1X5, Canada. [Martel, Richard; Comeau, Guillaume; Nadeau, Valerie] Univ Quebec, Inst Natl Rech Sci Eau Terre & Environm, Quebec City, PQ G1K 9A9, Canada. [Hewitt, Alan D.] Cold Reg Res & Engn Lab, Geol Sci Div, Hanover, NH 03755 USA. EM sylvie.brochu@drdc-rddc.gc.ca; Richard_Martel@inrs-ete.uquebec.ca; guillaume.comeau@inrs-ete.uquebec.ca; alan.d.hewitt@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 207-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804209 ER PT J AU Brochu, S Poulin, I Faucher, D Diaz, E Walsh, MR AF Brochu, Sylvie Poulin, Isabelle Faucher, Dominic Diaz, Emmanuela Walsh, Michael R. TI Environmental assessment of small arms live firing: Study of gaseous and particulate residues SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Brochu, Sylvie; Poulin, Isabelle; Faucher, Dominic; Diaz, Emmanuela] Def Res Dev Canada Valcartier, Energet Mat Sect, Quebec City, PQ G3J1X5, Canada. [Walsh, Michael R.] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. EM isabelle.poulin@drdc-rddc.gc.ca; emmanuela.diaz@drdc-rddc.gc.ca; michael.r.walsh@erdc.usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 208-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804204 ER PT J AU Chappell, M George, AJ Porter, B Price, CL AF Chappell, Mark George, Aaron J. Porter, Beth Price, Cynthia L. TI Reductive perchlorate degradation under water-unsaturated soil conditions SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Chappell, Mark; Price, Cynthia L.] US Army Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. [George, Aaron J.] SpecPro Inc, Vicksburg, MS 39180 USA. [Porter, Beth] SpecPro, Huntsville, AL 35805 USA. EM aaron.j.george@usace.army.mil; cynthia.l.price@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 213-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804240 ER PT J AU Chappell, M Price, CL Porter, BE Bourne, G Ford, L George, AJ AF Chappell, Mark Price, Cynthia L. Porter, Beth E. Bourne, Gerald Ford, Lesley George, Aaron J. TI Optimization of TNT partitioning coefficient (Kd) in marine sediments SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Chappell, Mark; Price, Cynthia L.] US Army Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. [Porter, Beth E.; Bourne, Gerald; Ford, Lesley; George, Aaron J.] SpecPro Inc, Vicksburg, MS 39180 USA. EM cynthia.l.price@usace.army.mil; beth.e.porter@usace.army.mil; gerald.g.bourne@usace.army.mil; lesley2247@msn.com; aaron.j.george@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 110-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804232 ER PT J AU Chappell, M George, AJ Mao, JD Bourne, G Price, CL AF Chappell, Mark George, Aaron J. Mao, Jingdong Bourne, Gerald Price, Cynthia L. TI Surfactive quality of humic substances for stabilizing carbon nanotube disperisons SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Chappell, Mark; Price, Cynthia L.] US Army Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. [George, Aaron J.; Bourne, Gerald] SpecPro Inc, Vicksburg, MS 39180 USA. [Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. EM aaron.j.george@usace.army.mil; jmao@odu.edu; gerald.g.bourne@usace.army.mil; cynthia.l.price@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 12-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804237 ER PT J AU Douglas, TA Walsh, ME Jones, AM Trainor, TP McGrath, CJ Weiss, CA AF Douglas, Thomas A. Walsh, M. E. Jones, Ashley M. Trainor, Thomas P. McGrath, Christian J. Weiss, Charles A. TI Fate of nitroaromatic (TNT) and nitramine (RDX and HMX) explosives on mineral surfaces SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Douglas, Thomas A.] Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Walsh, M. E.] USA, Erdc, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Jones, Ashley M.; Trainor, Thomas P.] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA. [McGrath, Christian J.] USA, Environm Lab, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. [Weiss, Charles A.] USA, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM thomas.a.douglas@usace.army.mil; marianne@crrel.usace.army.mil; fsamj@uaf.edu; fftpt@uaf.edu; christian.j.mcgrath@usace.army.mil; charles.a.weiss@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 242-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804084 ER PT J AU Glaspell, GP Anderson, J Wilkins, JR El-Shall, MS AF Glaspell, Garry P., II Anderson, John Wilkins, James R. El-Shall, M. Samy TI Vapor phase synthesis of upconverting nanocrystals to generate red, green, blue and white light SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Glaspell, Garry P., II; Anderson, John; Wilkins, James R.] USA, Topog Engn Ctr, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. [El-Shall, M. Samy] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA. EM gglaspell@gmail.com; mselshal@vcu.edu RI El-Shall, M. Samy/K-8954-2012 OI El-Shall, M. Samy/0000-0002-1013-4948 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 111-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857805016 ER PT J AU Gu, ZF Bauman, RA Long, JB AF Gu, Zengfa Bauman, Richard A. Long, Joseph B. TI Paraoxon-induced acute brain dysfunction: Increase of EEG (electroencephalography) delta power spectra in rats SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Gu, Zengfa; Bauman, Richard A.; Long, Joseph B.] Walter Reed Army Inst Res, Dept Polytrauma & Resuscitat Res, Silver Spring, MD 20910 USA. EM zengfa.gu@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 154-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804013 ER PT J AU Gutteridge, CE Baxter, MC Sadowski, BW O'Neil, MT McCalmont, WF Gerena, L AF Gutteridge, Clare E. Baxter, Michael C. Sadowski, Brett W. O'Neil, Michael T. McCalmont, William F. Gerena, Lucia TI Design of simpler analogs of a novel antimalarial agent to assist in pharmacophore identification SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Gutteridge, Clare E.; Baxter, Michael C.; Sadowski, Brett W.] USN Acad, Dept Chem, Annapolis, MD 21402 USA. [O'Neil, Michael T.; McCalmont, William F.; Gerena, Lucia] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM gutterid@usna.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 652-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857801208 ER PT J AU Gutteridge, CE Sadowski, BW Baxter, MC O'Neil, MT McCalmont, WF Gerena, L Montip, G AF Gutteridge, Clare E. Sadowski, Brett W. Baxter, Michael C. O'Neil, Michael T. McCalmont, William F. Gerena, Lucia Montip, Gettayacamin TI Identification and development of a novel series of antimalarial agents SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Gutteridge, Clare E.; Sadowski, Brett W.; Baxter, Michael C.] USN Acad, Dept Chem, Annapolis, MD 21402 USA. [O'Neil, Michael T.; McCalmont, William F.; Gerena, Lucia] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Montip, Gettayacamin] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. EM gutterid@usna.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 662-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857801179 ER PT J AU Hewitt, AD Walsh, ME Walsh, MR Bigl, S Chappell, M AF Hewitt, Alan D. Walsh, M. E. Walsh, Michael R. Bigl, Susan Chappell, Mark TI Assessing sample processing and sampling uncertainty for energetic residues on military training ranges: Method 8330B SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Hewitt, Alan D.; Walsh, Michael R.; Bigl, Susan] Cold Reg Res & Engn Lab, Geol Sci Div, Hanover, NH 03755 USA. [Walsh, M. E.] USA, Erdc, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Chappell, Mark] US Army Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. EM alan.d.hewitt@usace.army.mil; marianne@crrel.usace.army.mil; michael.r.walsh@erdc.usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 108-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804233 ER PT J AU Isayev, O Gorb, L Cenas, N Qasim, M Leszczynski, J AF Isayev, Olexandr Gorb, Leonid Cenas, Narimantas Qasim, Mo Leszczynski, Jerzy TI Theoretical insight into the nitroreductase mechanism SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Computat Ctr Mol Struct & Interact, Dept Chem, Jackson, MS 39217 USA. [Cenas, Narimantas] Lithuania Acad Sci, Inst Biochem, Dept Biochem Xenobiot, LT-232600 Vilnius, Lithuania. [Qasim, Mo] USA, Erdc, Vicksburg, MS 39180 USA. EM alex@ccmsi.us; lgorb@ccmsi.us; jerzy@ccmsi.us NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 94-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857803540 ER PT J AU Isayev, O Leszczynski, J Gorb, L Hill, F AF Isayev, Olexandr Leszczynski, Jerzy Gorb, Leonid Hill, Frances TI Ab initio and hybrid QM/MM simulations on massively parallel supercomputers: Experience at ERDC SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Leszczynski, Jerzy; Gorb, Leonid] Jackson State Univ, Computat Ctr Mol Struct & Interact, Dept Chem, Jackson, MS 39217 USA. [Hill, Frances] USA, ERDC, Vicksburg, MS 39180 USA. EM alex@ccmsi.us; jerzy@ccmsi.us; lgorb@ccmsi.us NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 90-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857803487 ER PT J AU Kaiser, TJ Franciszkowicz, M Riegner, DE AF Kaiser, Theodore J. Franciszkowicz, Marc Riegner, Dawn E. TI Quantitative analysis of video based instruction to enhance understanding in general chemistry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Kaiser, Theodore J.; Franciszkowicz, Marc; Riegner, Dawn E.] US Mil Acad, Dept Chem & Life Sci, ATTN, MADN CHM LS, West Point, NY 10996 USA. EM ted.kaiser@usma.edu; marc.franciszkowicz@usma.edu; dawn.riegner@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 1243-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857801341 ER PT J AU Kholod, Y Gorb, L Hill, F Qasim, M Leszczynski, J AF Kholod, Yana Gorb, Leonid Hill, Frances Qasim, Mo Leszczynski, Jerzy TI Computational predictions of environmentally important physical properties of explosives SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Kholod, Yana; Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Hill, Frances; Qasim, Mo] USA, Erdc, Vicksburg, MS 39180 USA. EM yana@ccmsi.us; lgorb@ccmsi.us; jerzy@ccmsi.us NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 229-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804078 ER PT J AU Lambeth, RH AF Lambeth, Robert H., III TI Tunable high glass-transition electro-optical polymers by ring opening metathesis polymerization SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Lambeth, Robert H., III] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM bob.lambeth@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 357-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857807461 ER PT J AU Lauer, J AF Lauer, Jason TI Correlating teaching methodology and learning style quantitatively using student scores and qualitatively using student surveys in general chemistry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Lauer, Jason] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. EM Jason.Lauer@usma.edu NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 1274-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857802616 ER PT J AU Lotufo, GR Rosen, G Wild, W AF Lotufo, Guilherme R. Rosen, Gunther Wild, William TI Ecotoxicology of munitions constituents in the marine environment SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Lotufo, Guilherme R.] ERDC USACE, Environm Lab, Vicksburg, MS 39180 USA. [Rosen, Gunther; Wild, William] SPAWAR Syst Ctr Pacific, San Diego, CA 92152 USA. EM Guilherme.Lotufo@erdc.usace.army.mil; gunther.rosen@navy.mil; bill.wild@navy.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 244-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804168 ER PT J AU Luthy, RG Cho, YM Ghosh, U Kennedy, AJ Bridges, TS AF Luthy, Richard G. Cho, Yeo-Myoung Ghosh, Upal Kennedy, Alan J. Bridges, Todd S. TI Field application of activated carbon amendment for in situ stabilization of PCBs in sediment SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Luthy, Richard G.; Cho, Yeo-Myoung] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. [Ghosh, Upal] Univ Maryland Baltimore Cty, Dept Civil & Environm Engn, Baltimore, MD 21250 USA. [Kennedy, Alan J.; Bridges, Todd S.] ERDC USACE, Environm Lab, Vicksburg, MS 39180 USA. EM luthy@stanford.edu; daybreak@stanford.edu; ughosh@umbc.edu; Alan.J.Kennedy@usace.army.mil; Todd.S.Bridges@erdc.usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 148-GEOC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804314 ER PT J AU Mattson, WD Rice, BM Balu, R AF Mattson, William D. Rice, Betsy M. Balu, Radhakrishnan TI Large-scale quantum mechanical simulations of materials under extreme conditions SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Mattson, William D.; Rice, Betsy M.; Balu, Radhakrishnan] USA, Weap Mat Res Directorate, Res Lab, Ballst & Weap Concept Div,AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. EM wmattson@arl.army.mil; betsyr@arl.army.mil; radbalu@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 61-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857803526 ER PT J AU Pennington, JC Lotufo, GR Hayes, C Porter, B George, R AF Pennington, Judith C. Lotufo, Guilherme R. Hayes, Charolett Porter, Beth George, Robert TI TNT, RDX, and HMX association with organic fractions of marine sediments and bioavailability implications SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Pennington, Judith C.; Lotufo, Guilherme R.] ERDC USACE, Environm Lab, Vicksburg, MS 39180 USA. [Hayes, Charolett; Porter, Beth] SpecPro, Huntsville, AL 35805 USA. [George, Robert] SPAWAR Syst Ctr Pacific, San Diego, CA 92152 USA. EM Guilherme.Lotufo@erdc.usace.army.mil; robert.george@navy.mil NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 111-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804202 ER PT J AU Price, CL Chappell, M George, AJ Bourne, G Ford, L Porter, BE AF Price, Cynthia L. Chappell, Mark George, Aaron J. Bourne, Gerald Ford, Lesley Porter, Beth E. TI Soil vadose zone chemistry of TNT and RDX under water-unsaturated conditions SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Price, Cynthia L.; Chappell, Mark] US Army Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. [George, Aaron J.; Bourne, Gerald; Ford, Lesley; Porter, Beth E.] SpecPro Inc, Vicksburg, MS 39180 USA. EM cynthia.l.price@usace.army.mil; aaron.j.george@usace.army.mil; gerald.g.bourne@usace.army.mil; lesley2247@msn.com; beth.e.porter@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 212-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804236 ER PT J AU Price, RA Bourne, M Lindsay, J Cole, J AF Price, Richard A. Bourne, Michelle Lindsay, James Cole, Jim TI Transport of RDX and TNT from Composition B explosive during simulated rainfall SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Price, Richard A.; Bourne, Michelle] US Army Corps Engineers, Vicksburg, MS 39180 USA. [Lindsay, James; Cole, Jim] Bowhead, Vicksburg, MS 39180 USA. EM richard.a.price@usace.army.mil; michelle.bourne@usace.army.mil; jay.lindsay@usace.army.mil; jim.cole@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 230-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804238 ER PT J AU Price, RA AF Price, Richard A. TI Thermal treatment of composition B residues by wildfire and managed burns SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Price, Richard A.] US Army Corps Engineers, Vicksburg, MS 39180 USA. EM richard.a.price@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 214-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804239 ER PT J AU Rawlett, AM Martin, G Orlicki, JA LaScala, JJ Zander, NE Demaree, JD Kosik, WE Andrews, K Baranoski, M Rice, N Kagumba, L Giaya, A AF Rawlett, Adam M. Martin, George Orlicki, Joshua A. LaScala, John J. Zander, Nicole E. Demaree, J. D. Kosik, W. E. Andrews, Kevin Baranoski, Myvan Rice, Norman Kagumba, Lawino Giaya, Arjan TI Nanoengineered self-segregating additives for reactive coatings SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Rawlett, Adam M.; Orlicki, Joshua A.; Zander, Nicole E.; Kosik, W. E.] USA, Div Mat, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Demaree, J. D.] USA, Weap & Mat Res Directorate, Res Lab, AMSRD ARL WM MA, Aberdeen Proving Ground, MD 21005 USA. [Andrews, Kevin] USA, Div Mat, Mat Applicat Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Rice, Norman; Kagumba, Lawino; Giaya, Arjan] Triton Syst Inc, Chelmsford, MA USA. EM arawlett@arl.army.mil; bob.martin6@arl.army.mil; jorlicki@arl.army.mil; nzander@arl.army.mil; mbaranos@arl.army.mil; Nrice@tritonsys.com; lkagumba@tritonsys.com; agiaya@tritonsys.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 232-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857807495 ER PT J AU Riegner, DE Kazmi, SH Kaplan, SEF Fountain, AW AF Riegner, Dawn E. Kazmi, Shuja H. Kaplan, Sarah E. F. Fountain, Augustus W., III TI Developing an LC-MS analysis protocol for ammonium and urea nitrate SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Riegner, Dawn E.; Kazmi, Shuja H.; Kaplan, Sarah E. F.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Fountain, Augustus W., III] AMSRD ECB RT, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM dawn.riegner@usma.edu; Shuja.Kazmi@usma.edu; augustus-fountain@us.army.mil NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 218-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857802220 ER PT J AU Riegner, DE Swayze, MD AF Riegner, Dawn E. Swayze, Michael D. TI Integration of automated solid-phase microextraction (SPME) with portable GC-TMS detection technology SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Riegner, Dawn E.; Swayze, Michael D.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. EM dawn.riegner@usma.edu; michael.swayze@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 235-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857802177 ER PT J AU Rosen, G Lotufo, GR Wild, W AF Rosen, Gunther Lotufo, Guilherme R. Wild, William TI Fate and effects of TNT and RDX released from Composition B fragments in marine microcosm exposures SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Rosen, Gunther; Wild, William] SPAWAR Syst Ctr Pacific, San Diego, CA 92152 USA. [Lotufo, Guilherme R.] ERDC USACE, Environm Lab, Vicksburg, MS 39180 USA. EM gunther.rosen@navy.mil; Guilherme.Lotufo@erdc.usace.army.mil; bill.wild@navy.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 231-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857804201 ER PT J AU Sliozberg, YR Andzelm, JW Brennan, JK VanLandingham, M Pryamitsyn, V Ganesan, V AF Sliozberg, Yelena R. Andzelm, Jan W. Brennan, John K. VanLandingham, Mark Pryamitsyn, Victor Ganesan, Venkat TI Morphology and rheology of the blend of amphiphilic ABA and AB block copolymers: DPD simulation study SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Sliozberg, Yelena R.; Andzelm, Jan W.; Brennan, John K.; VanLandingham, Mark] USA, Weap & Mat Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Pryamitsyn, Victor; Ganesan, Venkat] Univ Texas Austin, Dept Chem Engn, Austin, TX 78712 USA. EM yelena.r.sliozberg@arl.army.mil; jandzelm@arl.army.mil; venkat@che.utexas.edu RI Ganesan, Venkat/B-9912-2011; Pryamitsyn, Victor/J-4540-2013 OI Pryamitsyn, Victor/0000-0003-2128-7461 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 118-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857803598 ER PT J AU Synowczynski, J Andzelm, JW Vlachos, DG AF Synowczynski, Jennifer Andzelm, Jan W. Vlachos, Dionisios G. TI Theoretical investigation of inverse spillover processes on alumina supported Pt catalysts SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Synowczynski, Jennifer] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Andzelm, Jan W.] USA, Weap & Mat Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Vlachos, Dionisios G.] Univ Delaware, Dept Chem Engn, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA. EM jenns@arl.army.mil; jandzelm@arl.army.mil; vlachos@udel.edu NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 39-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857803466 ER PT J AU Wagner, GW AF Wagner, George W. TI Decontamination of chemical warfare agents with nanosize metal oxides. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Wagner, George W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM george.wagner@us.army.mil NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 22 PY 2009 VL 237 MA 47-IEC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V16GJ UT WOS:000207857802780 ER PT J AU Paul, KW Hurley, MM Irikura, KK AF Paul, Kristian W. Hurley, Margaret M. Irikura, Karl K. TI Unimolecular Decomposition of 5-Aminotetrazole and its Tautomer 5-Iminotetrazole: New Insight from Isopotential Searching SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID CORRELATED MOLECULAR CALCULATIONS; GAUSSIAN-BASIS SETS; THERMAL-DECOMPOSITION; ENERGETIC MATERIALS; TETRAZOLE DERIVATIVES; DENSITY; AMINOTETRAZOLES; EXPLOSIVES; CHEMISTRY; HYDROGEN AB Aminotetrazole compounds have become attractive ingredients in gas generating compositions, solid rocket propellants, and green pyrotechnics. Therefore, a fundamental understanding of their thermal decomposition mechanisms and thermodynamics is of great interest. In this study, the specular reflection isopotential searching method was used to investigate the unimolecular decomposition mechanisms of 5-iminotetrazole (5-ITZ), 1H-5-aminotetrazole (1H-5-ATZ), and 2H-5-aminotetrazole (2H-5-ATZ). Subsequent thermochemical analysis of the unimolecular decomposition pathways was performed at the CCSD(T)/aug-cc-pVTZ//B3LYP/6-311++G(3df,3pd) level of theory. Based upon the relative reaction barriers predicted in this study, the initial gaseous products of 5-ITZ unimolecular decomposition are HN(3),, and NH(2)CN (calculated activation barrier equal to 199.5 kJ/mol). On the other hand, the initial gaseous products of 1H-5-ATZ and 2H-5-ATZ unimolecular decomposition are predicted to be N(2) and metastable CH(3)N(3) (calculated activation barriers equal to 169.2 and 153.7 kJ/mol, respectively). These predicted unimolecular decomposition products and activation barriers are in excellent agreement with thermal decomposition experiments performed by Lesnikovich et al. [Lesnikovich, A.I., Ivashkevich, O. A.; Levchik, S. V.; Balabanovich, A. I.; Gaponik, P. N.; Kulak, A. A. Thermochim, Acta 2002, 388, 233], in which the apparent activation barriers were measured to be approximately 200 and 150 kJ/mol, respectively, for 5-ITZ and 1H-5-ATZ/2H-5-ATZ. C1 [Irikura, Karl K.] Natl Inst Stand & Technol, Computat Chem Grp, Gaithersburg, MD 20899 USA. [Paul, Kristian W.; Hurley, Margaret M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Paul, KW (reprint author), DuPont Crop Protect, Stine Haskell Res Ctr, Newark, DE 19714 USA. EM kristian.paul@usa.dupont.com; hurley@arl.army.mil RI Irikura, Karl/A-4266-2009 OI Irikura, Karl/0000-0001-7515-6761 FU Army Environmental Quality Technology Program; National Research Council Research Associateship Award at the Army Research Laboratory FX The authors are grateful to the Army Environmental Quality Technology Program for financial support. This research was performed while K.W.P. held a National Research Council Research Associateship Award at the Army Research Laboratory. All calculations were performed at the ARL and AFRL Major Shared Resource Centers of the Department of Defense High Performance Computing Modernization Program. The authors also wish to thank the referees for helpful comments. NR 35 TC 22 Z9 22 U1 0 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD MAR 19 PY 2009 VL 113 IS 11 BP 2483 EP 2490 DI 10.1021/jp810359t PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 417XE UT WOS:000264111000029 PM 19236036 ER PT J AU Valcour, VG Shiramizu, BT Sithinamsuwan, P Nidhinandana, S Ratto-Kim, S Ananworanich, J Siangphoe, U Kim, JH de Souza, M Degruttola, V Paul, RH Shikuma, CM AF Valcour, V. G. Shiramizu, B. T. Sithinamsuwan, P. Nidhinandana, S. Ratto-Kim, S. Ananworanich, J. Siangphoe, U. Kim, J. H. de Souza, M. Degruttola, V. Paul, R. H. Shikuma, C. M. CA Univ Hawaii TI HIV DNA and cognition in a Thai longitudinal HAART initiation cohort The SEARCH 001 Cohort Study SO NEUROLOGY LA English DT Article ID SIMIAN IMMUNODEFICIENCY VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; BLOOD MONONUCLEAR-CELLS; NEUROCOGNITIVE IMPAIRMENT; DISEASE PROGRESSION; IMMUNE ACTIVATION; RESIDUAL VIREMIA; RISK-FACTORS; VISNA VIRUS; DEMENTIA AB Objectives: The extent to which highly active antiretroviral therapy (HAART) era cognitive disorders are due to active processes, incomplete clearance of reservoirs, or comorbidities is controversial. This study aimed to determine if immunologic and virologic factors influence cognition after first-time HAART in Thai individuals with HIV-associated dementia (HAD) and Thai individuals without HAD (non-HAD). Methods: Variables were captured longitudinally to determine factors predictive of degree of cognitive recovery after first-time HAART. Neuropsychological data were compared to those of 230 HIV-negative Thai controls. Results: HIV RNA and CD4 lymphocyte counts were not predictive of HAD cross-sectionally or degree of cognitive improvement longitudinally. In contrast, baseline and longitudinal HIV DNA isolated from monocytes correlated to cognitive performance irrespective of plasma HIV RNA and CD4 lymphocyte counts pre-HAART (p < 0.001) and at 48 weeks post HAART (p < 0.001). Levels exceeding 3.5 log(10) copies HIV DNA/10(6) monocyte at baseline distinguished all HAD and non-HAD cases (p < 0.001). At 48 weeks, monocyte HIV DNA was below the level of detection of our assay (10 copies/10(6) cells) in 15/15 non-HAD compared to only 4/12 HAD cases, despite undetectable plasma HIV RNA in 26/27 cases. Baseline monocyte HIV DNA predicted 48-week cognitive performance on a composite score, independently of concurrent monocyte HIV DNA and CD4 count (p < 0.001). Conclusions: Monocyte HIV DNA level correlates to cognitive performance before highly active antiretroviral therapy (HAART) and 48 weeks after HAART in this cohort and baseline monocyte HIV DNA may predict 48-week cognitive performance. These findings raise the possibility that short-term incomplete cognitive recovery with HAART may represent an active process related to this peripheral reservoir. Neurology (R) 2009; 72: 992-998 C1 [Valcour, V. G.; Shiramizu, B. T.; Ratto-Kim, S.; Ananworanich, J.; Kim, J. H.; Shikuma, C. M.] Univ Hawaii, John A Burns Sch Med, Hawaii AIDS Clin Res Program, Honolulu, HI 96822 USA. [Valcour, V. G.] Univ Calif San Francisco, Dept Neurol, Aging Ctr, San Francisco, CA 94143 USA. [Sithinamsuwan, P.; Nidhinandana, S.] Phramongkutklao Hosp, Dept Med, Div Neurol, Bangkok, Thailand. [Ratto-Kim, S.; Kim, J. H.; de Souza, M.] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Ananworanich, J.; Siangphoe, U.] SE Asia Res Collaborat Hawaii, Bangkok, Thailand. [Degruttola, V.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Paul, R. H.] Univ Missouri, Dept Psychol, Div Behav Neurosci, St Louis, MO 63121 USA. RP Valcour, VG (reprint author), Care of Shikuma C, Lcahi Hosp, Hawaii AIDS Clin Res Program, Young 5th Floor,3675 Kilauea Ave, Honolulu, HI 96816 USA. EM Vvalcour@hawaii.edu FU NIH [R21MH072388, R01NS053345, K23MH65857] FX Supported by NIH R21MH072388, R01NS053345, and K23MH65857. The antiretrovirals were provided via standard clinical care through the Thai Ministry of Public Health Antiretroviral Treatment Program. NR 36 TC 34 Z9 34 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAR 17 PY 2009 VL 72 IS 11 BP 992 EP 998 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA 419TW UT WOS:000264243600010 PM 19289739 ER PT J AU Mohamadzadeh, M Duong, T Sandwick, SJ Hoover, T Klaenhammer, TR AF Mohamadzadeh, M. Duong, T. Sandwick, S. J. Hoover, T. Klaenhammer, T. R. TI Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE anthrax; lactic acid bacteria; mucosal immunity; oral; vaccine ID LACTIC-ACID BACTERIA; RECOMBINANT LACTOCOCCUS-LACTIS; IMMUNE-RESPONSES; CHOLERA-TOXIN; ORAL IMMUNIZATION; PEYERS PATCH; MUCOSAL; VACCINES; IGA; DIFFERENTIATION AB Efficient vaccines potentiate antibody avidity and increase T cell longevity, which confer protection against microbial lethal challenge. A vaccine strategy was established by using Lactobacillus acidophilus to deliver Bacillus anthracis protective antigen (PA) via specific dendritic cell-targeting peptides to dendritic cells (DCs), which reside in the periphery and mucosal surfaces, thus directing and regulating acquired immunity. The efficiency of oral delivery of L. acidophilus expressing a PA-DCpep fusion was evaluated in mice challenged with lethal B. anthracis Sterne. Vaccination with L. acidophilus expressing PA-DCpep induced robust protective immunity against B. anthracis Sterne compared with mice vaccinated with L. acidophilus expressing PA-control peptide or an empty vector. Additionally, serum anti-PA titers, neutralizing PA antibodies, and the levels of IgA-expressing cells were all comparable with the historical recombinant PA plus aluminum hydroxide vaccine administered s.c. Collectively, development of this strategy for oral delivery of DC-targeted antigens provides a safe and protective vaccine via a bacterial adjuvant that may potentiate mucosal immune responses against deadly pathogens. C1 [Mohamadzadeh, M.] Northwestern Univ, Sch Med, Chicago, IL 60611 USA. [Sandwick, S. J.; Hoover, T.] USA, Med Res Inst Infect Dis, Frederick, MD 21792 USA. [Duong, T.; Klaenhammer, T. R.] N Carolina State Univ, Genom Sci Grad Program, Raleigh, NC 27695 USA. [Duong, T.; Klaenhammer, T. R.] N Carolina State Univ, Dept Food Bioproc & Nutr Sci, Raleigh, NC 27695 USA. RP Mohamadzadeh, M (reprint author), Northwestern Univ, Sch Med, 303 E Chicago Ave,Searle 10-526, Chicago, IL 60611 USA. EM m.zadeh@northwestern.edu; klaenhammer@ncsu.edu RI Duong, Tri/B-5594-2012 OI Duong, Tri/0000-0002-4803-8564 FU National Institutes of Health [R21-AI059590]; North Carolina Dairy Foundation; National Science Foundation FX We thank Dr. K. Steele, D. Lane, Dr. R. Panchal, M. Kennedy, and W. Ribot for fruitful discussion and assistance in conducting various experiments related to this project. Work conducted at North Carolina State University was supported by National Institutes of Health Grant R21-AI059590 and the North Carolina Dairy Foundation. T. D. was supported by a National Science Foundation Integrated Graduate Education and Research Traineeship in Functional Genomics. NR 47 TC 93 Z9 100 U1 1 U2 17 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAR 17 PY 2009 VL 106 IS 11 BP 4331 EP 4336 DI 10.1073/pnas.0900029106 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 420HD UT WOS:000264278800051 PM 19246373 ER PT J AU Lee, JH Feng, XH Posmentier, ES Faiia, AM Taylor, S AF Lee, Jeonghoon Feng, Xiahong Posmentier, Eric S. Faiia, Anthony M. Taylor, Susan TI Stable isotopic exchange rate constant between snow and liquid water SO CHEMICAL GEOLOGY LA English DT Article DE Isotopic exchange rate constants; Snowmelt isotope; Liquid to ice ratio ID ONE-DIMENSIONAL MODEL; HYDROGRAPH SEPARATION; MELTING SNOWPACK; OXYGEN-ISOTOPE; FRACTIONATION; EVOLUTION; CATCHMENT; MELTWATER; RUNOFF AB The isotopic exchange rate between liquid water and ice is crucial in determining the isotopic evolution of a snowpack and its melt. The rate constant for oxygen isotopic exchange has been reported by Tayloretal. [Taylor, S., Feng, X, Renshaw, C.E., Kirchner,J.W., 2002a. Isotopic evolution of snowmelt-2. Verification and parameterization of a one-dimensional model using laboratory experiments. Water Resources Research 38(10), 1218. doi:10.1029/2001WR000815] using three melting experiments with different column heights and melting rates. In this work, we obtained the hydrogen isotopic exchange rate constant using samples from two out of three experiments in Taylor et al. [Taylor, S., Feng, X., Renshaw, C.E., Kirchner,J.W., 2002a. Isotopic evolution of snowmelt-2. Verification and parameterization of a one-dimensional model using laboratory experiments. Water Resources Research 38 (10),1218. doi: 10.1029/2001WR000815]. The 1-D model developed by Feng et al. [Feng, X, Taylor, S., Renshaw, C.E., Kirchner, J.W., 2002. Isotopic evolution of snowmelt-1. A physically based one-dimensional model. Water Resources Research 38(10),1217. doi: 10.1029/2001WR000814] was fit to the isotopic results by adjusting the value of two parameters, the isotopic exchange rite constant (k(r)) and the fraction of ice participating in the exchange (f). We report that the best estimated k(r) values are from 0.070 to 0.19 h(-1) for oxygen isotopic exchange between liquid and ice, and 0.078 to 020 h(-1) for hydrogen exchange. The model results suggest that f, the fraction of ice involved in the isotopic exchange, increases with increasing wetness of snow, and is related to snow metamorphism. We discuss the physical significance of the observed variations in k(r) and f. The relationship between delta D and delta(18)O in the melt water is modeled, and the slope is close to 6. This slope is significantly different from the slope of the meteoric water line, while it is close to the ratio of ice-liquid fractionation of hydrogen to that of oxygen. (C) 2008 Elsevier B.V. All rights reserved. C1 [Lee, Jeonghoon; Feng, Xiahong; Posmentier, Eric S.; Faiia, Anthony M.] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. [Taylor, Susan] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Lee, JH (reprint author), CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA. EM jeonghoon.lee@jpl.nasa.gov RI Lee, Jeonghoon/C-7354-2008; Lee, Jeonghoon/E-8116-2010 OI Lee, Jeonghoon/0000-0002-1256-4431 FU National Science Foundation [EAR-9903281, EAR-0111403, EAR 0418809]; Dartmouth College FX This research was partially supported by the National Science Foundation (EAR-9903281, EAR-0111403, EAR 0418809) and by Dartmouth College. NR 25 TC 13 Z9 13 U1 5 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2541 J9 CHEM GEOL JI Chem. Geol. PD MAR 15 PY 2009 VL 260 IS 1-2 BP 57 EP 62 DI 10.1016/j.chemgeo.2008.11.023 PG 6 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 424RA UT WOS:000264583100005 ER PT J AU Michalsen, MM Peacock, AD Smithgal, AN White, DC Spain, AM Sanchez-Rosario, Y Krumholz, LR Kelly, SD Kemner, KM Mckinley, J Heald, SM Bogle, MA Watson, DB Istok, JD AF Michalsen, Mandy M. Peacock, Aaron D. Smithgal, Amanda N. White, David C. Spain, Anne M. Sanchez-Rosario, Yamil Krumholz, Lee R. Kelly, Shelly D. Kemner, Kenneth M. Mckinley, James Heald, Steve M. Bogle, Mary Anna Watson, David B. Istok, Jonathan D. TI Treatment of Nitric Acid-, U(VI)-, and Tc(VII)-Contaminated Groundwater in Intermediate-Scale Physical Models of an In Situ Biobarrier SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID CONTAMINATED SUBSURFACE SEDIMENTS; PHOSPHOLIPID FATTY-ACID; REAL-TIME PCR; MICROBIAL COMMUNITIES; RIBOSOMAL-RNA; SP-NOV; FE(III)-REDUCING BACTERIA; REDUCING CONDITIONS; POROUS-MEDIUM; SAND COLUMNS AB Metal and hydrogen ion acidity and extreme nitrate concentratons at Department of Energy legacy waste sites pose challenges for successful in situ U and Tc bioimmobilization. In this study, we investigated a potential in situ biobarrier configuration designed to neutralize pH and remove nitrate and radionuclides from nitric acid-, U-, and Tc-contaminated groundwater for over 21 months. Ethanol additions to groundwater flowing through native sediment and crushed limestone effectively increased pH (from 4.7 to 6.9), promoted removal of 116 mM nitrate, increased sediment biomass, and immobilized 94% of total U. Increased groundwater pH and significant U removal was also observed in a control column that received no added ethanol. Sequential extraction and XANES analyses showed U in this sediment to be solid-associated U(VI), and EXAFS analysis results were consistent with uranyl orthophosphate (UO(2))(3)(PO(4))(2)center dot 4H(2)O(s), which may control U solubility in this system. Ratios of respiratory ubiquinones to menaquinones and copies of dissimilatory nitrite reductase genes, nirS and nirK, were at least 1 order of magnitude greater in the ethanol-stimulated system compared to the control, indicating that ethanol addition promoted growth of a largely denitrifying microbial community. Sediment 16S rRNA gene clone libraries showed that Betaproteobacteria were dominant (89%) near the source of influent acidic groundwater, whereas members of Gamma- and Alphaproteobacteria and Bacteroidetes increased along the flow path as pH increased and nitrate concentrations decreased, indicating spatial shifts in community composition as a function of pH and nitrate concentrations. Results of this study support the utility of biobarriers for treating acidic radionuclide- and nitrate-contaminated groundwater. C1 [Michalsen, Mandy M.] USA, Corps Engineers, Environm Engn & Technol Sect, Seattle, WA 98134 USA. [Peacock, Aaron D.; Smithgal, Amanda N.; White, David C.] Univ Tennessee, Ctr Biomarker Anal, Knoxville, TN 37932 USA. [Spain, Anne M.; Sanchez-Rosario, Yamil; Krumholz, Lee R.] Univ Oklahoma, Dept Bot & Microbiol, Norman, OK 73019 USA. [Mckinley, James] Pacific NW Natl Lab, William R Wiley Lab, Richland, WA 99352 USA. [Heald, Steve M.] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA. [Bogle, Mary Anna; Watson, David B.] Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN 37831 USA. [Istok, Jonathan D.] Oregon State Univ, Dept Civil Engn, Corvallis, OR 97331 USA. RP Michalsen, MM (reprint author), USA, Corps Engineers, Environm Engn & Technol Sect, Seattle, WA 98134 USA. EM mandy.m.michalsen@usace.army.mil RI ID, MRCAT/G-7586-2011; Watson, David/C-3256-2016 OI Watson, David/0000-0002-4972-4136 FU DOE Office of Science (OS) [FG03-02ER63443, DE-FC02-96ER62278, FG02-OOER62986, FSU F48792, DE-AC02-06CH11357]; Office of Biological and Environmental Research (BER); Environmental Remediation Sciences Program (ERSP); Integrative Graduate Education and Research Traineeship (IGERT); National Science Foundation; NSERC FX This research was supported by Grants FG03-02ER63443, DE-FC02-96ER62278, and FG02-OOER62986 (subcontract FSU F48792) from the DOE Office of Science (OS), Office of Biological and Environmental Research (BER), Environmental Remediation Sciences Program (ERSP) (formerly Natural and Accelerated Bioremediation Research Program). Additional support was provided by Integrative Graduate Education and Research Traineeship (IGERT) grant from the National Science Foundation. The Advanced Photon Source (APS) is supported by the DOE OS, Office of Basic Energy Sciences under Contract DE-AC02-06CH11357. The Materials Research Collaborative Access Team (MR-CAT) operations are supported by the US DOE OS and the MR-CAT member institutions. The PNC/XOR facilities are supported by the US DOE OS, the APS, a major facilities access grant from NSERC, the University of Washington, and Simon Fraser University. We also thank Jesse Jones, Robert Laughman, Ben Garcia, Ellie Seiko, Melora Park, and Mohammad Azizian for their help in field and laboratory work. NR 84 TC 12 Z9 12 U1 1 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAR 15 PY 2009 VL 43 IS 6 BP 1952 EP 1961 DI 10.1021/es8012485 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 417WI UT WOS:000264108800049 PM 19368198 ER PT J AU Cochrane, CJ Lenahan, PM Lelis, AJ AF Cochrane, C. J. Lenahan, P. M. Lelis, A. J. TI Direct observation of lifetime killing defects in 4H SiC epitaxial layers through spin dependent recombination in bipolar junction transistors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID 4H-SIC EPILAYERS; SILICON-CARBIDE; RESONANCE AB We have identified a magnetic resonance spectrum associated with minority carrier lifetime killing defects in device quality 4H SiC through magnetic resonance measurements in bipolar junction transistors using spin dependent recombination (SDR). The SDR spectrum has nine distinguishable lines; it is, within experimental error, essentially isotropic with four distinguishable pairs of side peaks symmetric about the strong center line. The line shape is, within experimental error, independent of bias voltage and recombination current. The large amplitude and spacing of the inner pair of side peaks and three more widely separated pairs of side peaks are not consistent with either a simple silicon or carbon vacancy or a carbon or silicon antisite. This indicates that the lifetime killing defect is not a simple defect but a defect aggregate. The spectrum is consistent with a multidefect cluster with an electron spin S=1/2. (The observed spectrum has not been reported previously in the magnetic resonance literature on SiC.) A fairly strong argument can be made in terms of a first order model linking the SDR spectrum to a divacancy or possibly a vacancy/antisite pair. The SDR amplitude versus gate voltage is semiquantitatively consistent with a very simple model in which the defect is uniformly distributed within the depletion region of the base/collector junction and is also the dominating recombination center. The large relative amplitude of the SDR response is more nearly consistent with a Kaplan-Solomon-Mott-like model for spin dependent recombination than the Lepine model. (c) 2009 American Institute of Physics. C1 [Cochrane, C. J.; Lenahan, P. M.] Penn State Univ, University Pk, PA 16802 USA. [Lelis, A. J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Cochrane, CJ (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM pml8@psu.edu FU U. S. Army Research Laboratory, Adelphi, MD FX The work at Pennsylvania State University was supported by the U. S. Army Research Laboratory, Adelphi, MD. NR 27 TC 9 Z9 9 U1 0 U2 12 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 15 PY 2009 VL 105 IS 6 AR 064502 DI 10.1063/1.3081644 PG 7 WC Physics, Applied SC Physics GA 427IW UT WOS:000264774000163 ER PT J AU Swartz, SL Matter, PH Arkenberg, GB Holcomb, FH Josefik, NM AF Swartz, Scott L. Matter, Paul H. Arkenberg, Gene B. Holcomb, Franklin H. Josefik, Nicholas M. TI Hydrogen production from E85 fuel with ceria-based catalysts SO JOURNAL OF POWER SOURCES LA English DT Article DE E85; Ethanol; Iso-octane; Steam reforming; Ceria; Rhodium ID SULFUR TOLERANT NANOCATALYSTS; LOW-TEMPERATURE; BIMETALLIC CATALYSTS; PARTIAL OXIDATION; RH; ETHANOL; FORMULATIONS; REACTOR; GAS AB The use of renewable (crop-derived) fuels to produce hydrogen has considerable environmental advantages with respect to reducing net emissions of carbon dioxide into the atmosphere. Ethanol is an example of a renewable fuel from which hydrogen can be derived, and E85 is a commercially available ethanol-based fuel of increasing importance. The distributed production of hydrogen from E85 fuel is one potential way of assuring availability of hydrogen as PEM fuel cells are introduced into service. NexTech Materials is collaborating with the U.S. Army Construction Engineering Laboratory (CERL) on the development of a hydrogen reformation process for E85 fuel. This paper describes the technical status of E85 fuel reforming process development work using Rh/ceria catalysts. Reforming results are compared for steam reforming and oxidative steam reforming of ethanol (the primary constituent or E85 fuel), isooctane, ethanol/iso-octane fuel mixtures (as a surrogate to E85), and commercially available E85 fuel. Stable reforming of E85 at 800 C and a space velocity of 58,000 scm(3) g(cat) (-1) h (1) over a 200-h period is reported. (C) 2008 Elsevier B.V. All rights reserved. C1 [Swartz, Scott L.; Matter, Paul H.; Arkenberg, Gene B.] NexTech Mat Ltd, Lewis Ctr, Lewis Ctr, OH 43035 USA. [Holcomb, Franklin H.; Josefik, Nicholas M.] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, ERDC CERL, Champaign, IL 61826 USA. RP Matter, PH (reprint author), NexTech Mat Ltd, Lewis Ctr, 404 Enterprise Dr, Lewis Ctr, OH 43035 USA. EM p.matter@nextechmaterials.com; Franklin.H.Holcomb@erdc.usace.army.mil FU U.S. Army [W9132T-07-C-0005] FX This work was funded by the U.S. Army under Contract No. W9132T-07-C-0005. NR 16 TC 8 Z9 8 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAR 15 PY 2009 VL 188 IS 2 BP 515 EP 520 DI 10.1016/j.jpowsour.2008.12.006 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 425OL UT WOS:000264646900025 ER PT J AU Zhang, SS Foster, D Read, J AF Zhang, Sheng S. Foster, Donald Read, Jeffrey TI A low temperature electrolyte for primary Li/CFx batteries SO JOURNAL OF POWER SOURCES LA English DT Article DE Li/CFx battery; Low temperature electrolyte; Acetonitrile; gamma-Butyrolactone; Carbon monofluoride ID DOUBLE-LAYER CAPACITORS; LI-CFX BATTERIES; LITHIUM BATTERIES; PERFORMANCE; CELLS AB In this work, a 1:1 by weight blend of acetonitrile (AN) and gamma-butyrolactone (BL) was studied as the solvent of low temperature electrolyte for high energy density Li/CFx batteries. Both visual observation and impedance analysis show that metallic Li is kinetically stable in a 0.5 m LiBF4 1:1 AN/BL electrolyte. This property is attributed to the formation of a protective passivation film on the surface of metallic Li, and it has been successfully used to develop the low temperature electrolyte for Li/CFx cells. It is shown that the cell with such an electrolyte outperforms the control cell with 0.5 m LiBF4 1:1 (wt.) propylene carbonate (PC)/1,2-dimethoxyethane (DME) electrolyte in both power capability and low temperature discharge performance. Impedance analyses reveal that the improved discharge performance is attributed to the reduction in both the bulk resistance and cell reaction resistance of the Li/CFx cell. which is related to the high ionic conductivity of the AN/BL electrolyte. Due to the chemical incompatibility between metallic U and AN at high temperatures, the storage and operation temperature for the Li/CFx cells with 0.5 m LiBF4 1: 1 AN/BL electrolyte is limited to or below ambient temperature (30 degrees C). Published by Elsevier B.V. C1 [Zhang, Sheng S.; Foster, Donald; Read, Jeffrey] USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 21 TC 14 Z9 16 U1 5 U2 48 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAR 15 PY 2009 VL 188 IS 2 SI SI BP 532 EP 537 DI 10.1016/j.jpowsour.2008.12.030 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 425OL UT WOS:000264646900028 ER PT J AU Zhang, SS Foster, D Read, J AF Zhang, Sheng S. Foster, Donald Read, Jeffrey TI Enhancement of discharge performance of Li/CFx cell by thermal treatment of CFx cathode material SO JOURNAL OF POWER SOURCES LA English DT Article DE Carbon fluoride; Subfluorinated carbon; Discharge; Impedance; Li/CFx battery ID POLY(CARBON MONOFLUORIDE); LITHIUM BATTERIES; GRAPHITE OXIDE; DECOMPOSITION AB In this work we demonstrate that the thermal treatment of CFx cathode material just below the decomposition temperature can enhance discharge performance of Li/CFx cells. The performance enhancement becomes more effective when heating a mixture of CFx and citric acid (CA) since CA serves as an extra carbon source. Discharge experiments show that the thermal treatment not only reduces initial voltage delay, but also raises discharge voltage. Whereas the measurement of powder impedance indicates the thermal treatment does not increase electronic conductivity of CFx material. Based on these facts, we propose that the thermal treatment results in a limited decomposition of CFx, which yields a subfluorinated carbon (CFx-delta), instead of a highly conductive carbon. In the case of CFx/AC mixture, the AC provides extra carbon that reacts with F-2 and fluorocarbon radicals generated by the thermal decomposition of CFx to form subfluorinated carbon. The process of thermal treatment is studied by thermogravimetric analysis and X-ray diffraction, and the effect of treatment conditions such as heating temperature, heating time and CFx/CA ratio on the discharge performance of CFx cathode is discussed. As an example, a Li/CFx cell using CFx treated with CA at 500 degrees C under nitrogen for 2 h achieved theretical specific capacity when being discharged at C/5. Impedance analysis indicates that the enhanced performance is attributed to a significant reduction in the cell reaction resistance. Published by Elsevier B.V. C1 [Zhang, Sheng S.; Foster, Donald; Read, Jeffrey] USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 17 TC 21 Z9 21 U1 4 U2 43 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAR 15 PY 2009 VL 188 IS 2 SI SI BP 601 EP 605 DI 10.1016/j.jpowsour.2008.12.007 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 425OL UT WOS:000264646900040 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Masters and Commanders: How Four Titans Won the War in the West, 1941-1945 SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 15 PY 2009 VL 134 IS 5 BP 112 EP 112 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 423VE UT WOS:000264523000086 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Weller's War: A Legendary Foreign Correspondent's Saga of World War II on Five Continents SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 15 PY 2009 VL 134 IS 5 BP 113 EP + PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 423VE UT WOS:000264523000091 ER PT J AU Mathaudhu, SN Derosset, AJ Hartwig, KT Kecskes, LJ AF Mathaudhu, S. N. deRosset, A. J. Hartwig, K. T. Kecskes, L. J. TI Microstructures and recrystallization behavior of severely hot-deformed tungsten SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article; Proceedings Paper CT 1st International Symposium on Bulk Nanostructures Materials - From Fundamentals to Innovations CY AUG 14-18, 2007 CL Ufa State Aviat Tech Univ, Ufa, RUSSIA HO Ufa State Aviat Tech Univ DE ECAE; Microstructure; Recrystallization; Severe plastic deformation; Tungsten; Ultrafine grains AB When coarse-grained (CG) tungsten (W) is heavily worked by equal-channel angular extrusion (ECAE), the grain size is reduced to the ultrafine-grained/nanocrystal line regimes (UFG/NC) and the strength and ductility increase. Because of the brittle nature of CG W, the material must be hot-extruded, and, if the temperatures are near the recrystallization temperature (T(rc)), gains in properties may not be maximized. In this study, the recrystallization behavior of ECAE-processed CG W is examined as a function of the imparted strain (i.e., number of extrusions) and the hot-working extrusion temperature. Up to four ECAE passes were performed in tooling with a 90 degrees channel intersection, and at temperatures of 1000 degrees C or 1200 degrees C. Subsequent 60 min annealing of the worked material to 1600 degrees C allowed for the determination of T(rc). Vickers microhardness measurements and scanning electron microscopy, were used to characterize the microstructures in the as-worked and recrystallized states. The ECAE-processed W shows increased microstructural break-up and refinement with increasing strain and decreasing hot-working temperature in the fully worked state. T(rc) was determined to be similar to 1400 degrees C, which is nearly independent of the number of extrusions and the working temperature. These results show that if ECAE is accomplished below 1400 degrees C (i.e., at 1000 degrees C or lower) the attractive properties of the UFG/NC-worked W may be retained. Specifically, below 1000 degrees C, with increasing strain imparted to the material, high hardness values with a concomitant grain size refinement (similar to 350 nm) could be expected. published by Elsevier B.V. C1 [Mathaudhu, S. N.; deRosset, A. J.; Kecskes, L. J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Mathaudhu, S. N.; deRosset, A. J.] ORISE ORAU Maryland, Aberdeen Proving Ground, MD 21010 USA. [Hartwig, K. T.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. RP Mathaudhu, SN (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM Suveen.mathaudhu@arl.army.mil RI Mathaudhu, Suveen/B-4192-2009; Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 10 TC 20 Z9 25 U1 4 U2 31 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD MAR 15 PY 2009 VL 503 IS 1-2 SI SI BP 28 EP 31 DI 10.1016/j.msea.2008.03.051 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 414OD UT WOS:000263873100007 ER PT J AU Kulkarni, SS Lapedes, A Tang, H Gnanakaran, S Daniels, MG Zhang, M Bhattacharya, T Li, M Polonis, VR McCutchan, FE Morris, L Ellenberger, D Butera, ST Bollinger, RC Korber, BT Paranjape, RS Montefiori, DC AF Kulkarni, Smita S. Lapedes, Alan Tang, Haili Gnanakaran, S. Daniels, Marcus G. Zhang, Ming Bhattacharya, Tanmoy Li, Ming Polonis, Victoria R. McCutchan, Francine E. Morris, Lynn Ellenberger, Dennis Butera, Salvatore T. Bollinger, Robert C. Korber, Bette T. Paranjape, Ramesh S. Montefiori, David C. TI Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India SO VIROLOGY LA English DT Review DE HIV-1; Neutralizing antibodies; Envelope glycoproteins; Genetic signatures; Heatmap ID HUMAN-IMMUNODEFICIENCY-VIRUS; GP120 ENVELOPE GLYCOPROTEIN; PROXIMAL EXTERNAL REGION; CELL-SURFACE EXPRESSION; CORECEPTOR BINDING-SITE; GP41 CYTOPLASMIC TAIL; TYPE-1 ENVELOPE; ANTIBODY NEUTRALIZATION; MONOCLONAL-ANTIBODIES; GENETIC DIVERSITY AB Little is known about the neutralization properties of HIV-1 in India to optimally design and test vaccines. For this reason, a functional Env clone was obtained from each of ten newly acquired, heterosexually transmitted HIV-1 infections in Pune, Maharashtra, These clones formed a phylogenetically distinct genetic lineage within subtype C. As Env-pseudotyped Viruses the clones were mostly resistant to IgG1b12, 2G12 and 2F5 but all were sensitive to 4E10. When compared to a large multi-subtype panel of Env-pseudotyped viruses (subtypes B, C and CRF02_AG) in neutralization assays with a multi-subtype panel of HIV-1-positive plasma samples, the Indian Envs were remarkably complex. With the exception of the Indian Envs, results of a hierarchical clustering analysis showed a strong subtype association with the patterns of neutralization susceptibility. From these patterns we were able to identify 19 neutralization cluster-associated amino acid signatures in gp120 and 14 signatures in the ectodomain and cytoplasmic tail of gp41. We conclude that newly transmitted Indian Envs are antigenically complex in spite of close genetic similarity. Delineation of neutralization-associated amino acid signatures provides a deeper understanding of the antigenic structure of HIV-1 Env. (c) 2008 Elsevier Inc. All rights reserved. C1 [Tang, Haili; Li, Ming; Montefiori, David C.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Kulkarni, Smita S.; Paranjape, Ramesh S.] Natl AIDS Res Inst, Pune, Maharashtra, India. [Lapedes, Alan; Gnanakaran, S.; Daniels, Marcus G.; Zhang, Ming; Bhattacharya, Tanmoy; Korber, Bette T.] Los Alamos Natl Lab, Los Alamos, NM USA. [Polonis, Victoria R.; McCutchan, Francine E.] Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Polonis, Victoria R.; McCutchan, Francine E.] Henry M Jackson Fdn, Rockville, MD 20850 USA. [Morris, Lynn] Natl Inst Communicable Dis, Johannesburg, South Africa. [Ellenberger, Dennis; Butera, Salvatore T.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Bollinger, Robert C.] Johns Hopkins Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA. RP Montefiori, DC (reprint author), Duke Univ, Med Ctr, Dept Surg, Box 2926, Durham, NC 27710 USA. EM monte@duke.edu RI Bhattacharya, Tanmoy/J-8956-2013; OI Bhattacharya, Tanmoy/0000-0002-1060-652X; , Lynn/0000-0003-3961-7828; Gnanakaran, S/0000-0002-9368-3044; Korber, Bette/0000-0002-2026-5757 FU National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIAID, NIH) [A130034]; NIAID, NIH [Al 33879-02]; NIH-NCRR OPD-GCRC [5MOIRR00722]; Indian Council of Medical Research FX We gratefully acknowledge the staff of the "Acute Pathogenesis of HIV-1 Infection" project, National AIDS Research Institute, Pune, India who helped in collecting the samples and in generating the data. This work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIAID, NIH) (A130034) and by the Bill and Melinda Gates Foundation (#38619). This work was also supported in part by NIAID, NIH (Al 33879-02), NIH-NCRR OPD-GCRC (5MOIRR00722), the NIH-Fogarty International Center (D43TW0000), and intramural research grants from the Indian Council of Medical Research. NR 111 TC 47 Z9 47 U1 2 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD MAR 15 PY 2009 VL 385 IS 2 BP 505 EP 520 DI 10.1016/j.virol.2008.12.032 PG 16 WC Virology SC Virology GA 419XE UT WOS:000264252200024 PM 19167740 ER PT J AU Lisal, M Brennan, JK Smith, WR AF Lisal, Martin Brennan, John K. Smith, William R. TI Mesoscale simulation of polymer reaction equilibrium: Combining dissipative particle dynamics with reaction ensemble Monte Carlo. II. Supramolecular diblock copolymers SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article DE chemical equilibrium; Monte Carlo methods; polymer blends; polymerisation; thermodynamic properties ID MICROPHASE SEPARATION; COMPUTER-SIMULATION; BLENDS AB We present an alternative formulation of the reaction ensemble dissipative particle dynamics (RxDPD) method [M. Lisal, J. K. Brennan, and W. R. Smith, J. Chem. Phys. 125, 16490 (2006)], a mesoscale simulation technique for studying polymer systems in reaction equilibrium. The RxDPD method combines elements of dissipative particle dynamics (DPD) and reaction ensemble Monte Carlo (RxMC), and is primarily targeted for the prediction of the system composition, thermodynamic properties, and phase behavior of reaction equilibrium polymer systems. The alternative formulation of the RxDPD method is demonstrated by considering a supramolecular diblock copolymer (SDC) melt in which two homopolymers, A(n) and B(m), can reversibly bond at terminal binding sites to form a diblock copolymer, A(n)B(m). We consider the effect of the terminal binding sites and the chemical incompatibility between A- and B-segments on the phase behavior. Both effects are found to strongly influence the resulting phase behavior. Due to the reversible nature of the binding, the SDC melt can be treated as the reaction equilibrium system A(n)+B(m)-><- A(n)B(m). To simulate the A(n)+B(m)-><- A(n)B(m) melt, the system contains, in addition to full A(n), B(m), and A(n)B(m) polymers, two fractional polymers: one fractional polymer either fA(n) or fB(m), and one fractional polymer fA(n)B(m), which have fractional particles at the ends of the polymer chains. These fractional particles are coupled to the system via a coupling parameter. The time evolution of the system is governed by the DPD equations of motion, accompanied by random changes in the coupling parameter. Random changes in the coupling parameter mimic forward and reverse reaction steps as in the RxMC approach, and they are accepted with a probability derived from the expanded ensemble grand canonical partition function. Unlike the original RxDPD method that considers coupling of entire fractional polymers to the system, the expanded ensemble framework allows a stepwise coupling, thus greatly increasing the efficiency of the RxDPD approach. The RxDPD technique rigorously satisfies thermodynamic equilibrium, but not the hydrodynamic behavior. However, the approximate treatment of the hydrodynamics can be minimized by simulating a large number of particles. C1 [Lisal, Martin] Acad Sci Czech Republic, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, CR-16502 Prague 6, Suchdol, Czech Republic. [Lisal, Martin] Univ JE Purkyne, Inst Sci, Dept Phys, Usti Nad Labem 40096, Czech Republic. [Brennan, John K.] USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Smith, William R.] Univ Western Ontario, Inst Technol, Fac Sci, Oshawa, ON L1H 7K4, Canada. RP Lisal, M (reprint author), Acad Sci Czech Republic, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, CR-16502 Prague 6, Suchdol, Czech Republic. EM lisal@icpf.cas.cz RI Lisal, Martin/A-8176-2011; Smith, William/G-4404-2010 OI Lisal, Martin/0000-0001-8005-7143; Smith, William/0000-0002-1982-2050 FU Grant Agency of the Czech Republic [203/08/0094]; National Research Programme "Information Society" [1ET400720507]; Grant Programme of Academy of Sciences of the Czech Republic [KAN400720701]; European Community under the 6th Framework Programme [033304]; 7th Framework Programme [TD0802]; Natural Sciences and Research Council of Canada [OGP1041] FX This research was supported by the Grant Agency of the Czech Republic (Grant No. 203/08/0094), the National Research Programme "Information Society" (Project No. 1ET400720507), the Grant Programme of Academy of Sciences of the Czech Republic "Nanotechnology for Society" (Project No. KAN400720701), the European Community under the 6th Framework Programme (Project MULTIPRO No. 033304) and under the 7th Framework Programme (Project COST No. TD0802), and by the Natural Sciences and Research Council of Canada (Grant No. OGP1041); calculations were carried out on the SHARCNET network. NR 32 TC 14 Z9 14 U1 1 U2 22 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD MAR 14 PY 2009 VL 130 IS 10 AR 104902 DI 10.1063/1.3079139 PG 15 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 420IF UT WOS:000264281800038 PM 19292554 ER PT J AU Shukla, MK Dubey, M Zakar, E Leszczynski, J AF Shukla, Manoj K. Dubey, Madan Zakar, Eugene Leszczynski, Jerzy TI DFT Investigation of the Interaction of Gold Nanoclusters with Nucleic Acid Base Guanine and the Watson-Crick Guanine-Cytosine Base Pair SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID DNA BASES; THEORETICAL CHEMISTRY; IONIZATION-POTENTIALS; CLUSTERS; NANOPARTICLES; CYTOTOXICITY; COMPLEXES; SPECTRA; DENSITY; CELLS AB The interaction of gold nanoclusters (Au, n = 2, 4, 6, 8, 10, 12) with nucleic acid purine base guanine (G) and the Watson-Crick guanine-cytosine (GC) base pair through the major groove site (N7 site of guanine) of DNA was investigated theoretically. Geometries of complexes were optimized at the density functional theory (DFT) level employing the hybrid B3LYP functional. The 6-31G(d) basis set was used for all atoms except gold, for which the LANL2DZ effective core potential (ECP) was used. Natural population analysis was performed to determine NBO charges. The vertical first ionization potential and electron affinity of guanine and the guanine-cytosine base pair and their complexes with gold nanoclusters were also analyzed. It was revealed that gold clusters interact more strongly with the GC base pair than with isolated guanine. It was found that consequent to the binding of gold nanoclusters a substantial amount of electronic charge was transferred from guanine (or the guanine-cytosine base pair) to the gold clusters. Furthermore, the amount of the electronic charge transferred to the gold cluster was found to be larger for GC-Au(n) complexes than that in the G-Au(n) complexes. The vertical ionization potential, electron affinity, and biological significance of the interaction of gold nanoclusters with nucleic acid building blocks have also been discussed. C1 [Shukla, Manoj K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, NSF CREST Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. [Dubey, Madan; Zakar, Eugene] USA, Res Lab, Sensors & Elect Devices Directorate, AMSRD ARL SE RL, Adelphi, MD 20783 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, NSF CREST Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. EM jerzy@ccmsi.us RI kumar, Manoj/L-4079-2013 OI kumar, Manoj/0000-0002-3932-6505 NR 44 TC 25 Z9 25 U1 0 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAR 12 PY 2009 VL 113 IS 10 BP 3960 EP 3966 DI 10.1021/jp808622y PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 415ZM UT WOS:000263975000012 ER PT J AU Appel, DA McNear, JA Avedissian, L Castillo-Rojas, LM Atwood, JE Pearse, LA Potter, RN Burke, AP Tremaine, L Shry, EA Gentlesk, PJ Reich, SS Eckart, RE AF Appel, David A. McNear, Jennifer A. Avedissian, Lena Castillo-Rojas, Laudino M. Atwood, John E. Pearse, Lisa A. Potter, Robert N. Burke, Allen P. Tremaine, Ladd Shry, Eric A. Gentlesk, Philip J. Reich, Stephen S. Eckart, Robert E. TI Sudden Death Due to Coronary Disease in the Young: Examining Causes Other Than Atherosclerosis SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 58th Annual Scientific Session of the American-College-of-Cardiology CY MAR 28-31, 2009 CL Orlando, FL SP Amer Coll Cardiol C1 Brooke Army Med Ctr, US Dept Def, Cardiovasc Death Registry Grp, San Antonio, TX USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 10 PY 2009 VL 53 IS 10 BP A318 EP A318 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 414LD UT WOS:000263864201320 ER PT J AU Avedissian, L McNear, JA Appel, DA Castillo-Rojas, LM Atwood, JE Pearse, LA Potter, RN Burke, AP Tremaine, L Gentlesk, PJ Shry, EA Reich, SS Eckart, RE AF Avedissian, Lena McNear, Jennifer A. Appel, David A. Castillo-Rojas, Laudino M. Atwood, John E. Pearse, Lisa A. Potter, Robert N. Burke, Allen P. Tremaine, Ladd Gentlesk, Philip J. Shry, Eric A. Reich, Stephen S. Eckart, Robert E. TI Clinical and Pathologic Characteristics of Myocarditis as a Cause of Sudden Death SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 58th Annual Scientific Session of the American-College-of-Cardiology CY MAR 28-31, 2009 CL Orlando, FL SP Amer Coll Cardiol C1 Brooke Army Med Ctr, Dept Def, Cardiovasc Death Registry Grp, San Antonio, TX USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 10 PY 2009 VL 53 IS 10 BP A174 EP A174 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 414LD UT WOS:000263864200726 ER PT J AU Baggish, AL Fulco, CS Muza, S Rock, PB Beidleman, B Cymerman, A Yared, K Systrom, D Wood, MJ Weyman, AE Picard, MH Harris, NS AF Baggish, Aaron L. Fulco, Charles S. Muza, Stephen Rock, Paul B. Beidleman, Beth Cymerman, Allen Yared, Kibar Systrom, David Wood, Malissa J. Weyman, Arthur E. Picard, Michael H. Harris, N. Stuart TI Impact of Moderate Altitude Staging on Pulmonary Arterial Pressure During Ascent to High Altitude SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 58th Annual Scientific Session of the American-College-of-Cardiology CY MAR 28-31, 2009 CL Orlando, FL SP Amer Coll Cardiol C1 Massachusetts Gen Hosp, Boston, MA 02114 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 10 PY 2009 VL 53 IS 10 BP A449 EP A449 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 414LD UT WOS:000263864201864 ER PT J AU Castillo-Rojas, LM Appel, DA McNear, JA Avedissian, L Atwood, JE Pearse, LA Potter, RN Burke, AP Tremaine, L Shry, EA Gentlesk, PJ Reich, SS Eckart, RE AF Castillo-Rojas, Laudino M. Appel, David A. McNear, Jennifer A. Avedissian, Lena Atwood, John E. Pearse, Lisa A. Potter, Robert N. Burke, Allen P. Tremaine, Ladd Shry, Eric A. Gentlesk, Philip J. Reich, Stephen S. Eckart, Robert E. TI Exertional and Nonexertional Sudden Deaths: Re-examining the Role of Hypertrophic Cardiomyopathy SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 58th Annual Scientific Session of the American-College-of-Cardiology CY MAR 28-31, 2009 CL Orlando, FL SP Amer Coll Cardiol C1 Brooke Army Med Ctr, Dept Defense, Cardiovasc Death Registry Grp, San Antonio, TX USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 10 PY 2009 VL 53 IS 10 BP A348 EP A348 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 414LD UT WOS:000263864201442 ER PT J AU Castillo-Rojas, LM Appel, DA McNear, JA Avedissian, L Atwood, JE Pearse, LA Potter, RN Burke, AP Tremaine, L Shry, EA Gentlesk, PJ Reich, SS Eckart, RE AF Castillo-Rojas, Laudino M. Appel, David A. McNear, Jennifer A. Avedissian, Lena Atwood, John E. Pearse, Lisa A. Potter, Robert N. Burke, Allen P. Tremaine, Ladd Shry, Eric A. Gentlesk, Philip J. Reich, Stephen S. Eckart, Robert E. TI Sudden Death Due to Concentric Left Ventricular Hypertrophy in the Absence of Myofibrillary Disarray in African-Americans SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 58th Annual Scientific Session of the American-College-of-Cardiology CY MAR 28-31, 2009 CL Orlando, FL SP Amer Coll Cardiol C1 Brooke Army Med Ctr, Dept Def, Cardiovasc Death Registry Grp, San Antonio, TX USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 10 PY 2009 VL 53 IS 10 BP A172 EP A172 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 414LD UT WOS:000263864200717 ER PT J AU Gerasimon, G Gentlesk, PJ Peele, ME Eckart, RE AF Gerasimon, Gregg Gentlesk, Philip J. Peele, Mark E. Eckart, Robert E. TI Properties of Atrioventricular Accessory Pathways Are Concealed Pathways Safer in a Population With High Occupational Risk? SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 58th Annual Scientific Session of the American-College-of-Cardiology CY MAR 28-31, 2009 CL Orlando, FL SP Amer Coll Cardiol C1 [Gerasimon, Gregg; Gentlesk, Philip J.; Peele, Mark E.; Eckart, Robert E.] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 10 PY 2009 VL 53 IS 10 BP A111 EP A111 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 414LD UT WOS:000263864200460 ER PT J AU Taylor, AJ Munir, J Bindeman, J Bauer, K Byrd, C Wu, HY Feuerstein, I AF Taylor, Allen J. Munir, Jamalah Bindeman, Jody Bauer, Kelly Byrd, Carole Wu, Hongyan Feuerstein, Irwin TI The Perimenopausal Atherosclerosis Transition: Relationships of Calcified, Noncalcified, and Carotid Plaque to Risk Factors and Hormone Levels SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Meeting Abstract CT 58th Annual Scientific Session of the American-College-of-Cardiology CY MAR 28-31, 2009 CL Orlando, FL SP Amer Coll Cardiol C1 [Taylor, Allen J.; Munir, Jamalah; Bindeman, Jody; Bauer, Kelly; Byrd, Carole; Wu, Hongyan; Feuerstein, Irwin] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 10 PY 2009 VL 53 IS 10 BP A208 EP A208 PG 1 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 414LD UT WOS:000263864200864 ER PT J AU Bisson, IA Butler, LK Hayden, TJ Romero, LM Wikelski, MC AF Bisson, Isabelle-Anne Butler, Luke K. Hayden, Tim J. Romero, L. Michael Wikelski, Martin C. TI No energetic cost of anthropogenic disturbance in a songbird SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES LA English DT Article DE conservation; anthropogenic disturbance; heart rate telemetry; energy expenditure; fast life histories; Vireo ID HEART-RATE; BEHAVIORAL-RESPONSES; MAGELLANIC PENGUINS; OXYGEN-CONSUMPTION; STRESS; EXPENDITURE; CONSEQUENCES; REPRODUCTION; BIRDS; CALORIMETRY AB Anthropogenic or natural disturbances can have a significant impact on wild animals. Therefore, understanding when, how and what type of human and natural events disturb animals is a central problem in wildlife conservation. However, it can be difficult to identify which particular environmental stressor affects an individual most. We use heart rate telemetry to quantify the energy expenditure associated with different types of human-mediated and natural disturbances in a breeding passerine, the white-eyed vireo (Vireo griseus). We fitted 0.5 g heart rate transmitters to 14 male vireos and continuously recorded heart rate and activity for two days and three nights on a military installation. We calibrated heart rate to energy expenditure for five additional males using an open-flow, push-through respirometry system showing that heart rate predicted 74 per cent of energy expenditure. We conducted standardized disturbance trials in the field to experimentally simulate a natural stressor (predator presence) and two anthropogenic stressors. Although birds initially showed behavioural and heart rate reactions to some disturbances, we could not detect an overall increase in energy expenditure during 1- or 4-hours disturbances. Similarly, overall activity rates were unaltered between control and experimental periods, and birds continued to perform parental duties despite the experimental disturbances. We suggest that vireos quickly determined that disturbances were non-threatening and thus showed no (costly) physiological response. We hypothesize that the lack of a significant response to disturbance in vireos is adaptive and may be representative of animals with fast life histories (e. g. short lifespan, high reproductive output) so as to maximize energy allocation to reproduction. Conversely, we predict that energetic cost of human-mediated disturbances will be significant in slow-living animals. C1 [Bisson, Isabelle-Anne; Wikelski, Martin C.] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08540 USA. [Butler, Luke K.; Romero, L. Michael] Tufts Univ, Dept Biol, Medford, MA 02155 USA. [Hayden, Tim J.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Bisson, IA (reprint author), Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08540 USA. EM ibisson@princeton.edu FU US Army Corps of Engineers, Engineer Research and Development Center [W9132T-05-C-0023] FX We thank E. C. Fergus, J. Barry, J. L. Granger, S. Lovell, The Nature Conservancy ( Fort Hood Chapter) and the Fort Hood Natural Resources Management Branch for their assistance in the field. We would also like to thank M. Bowlin, R. Charif and N. Hristov for their assistance with the data acquisition and processing. This project was supported by the Department of Defense, Strategic Environmental Research and Development Program, project CS-1396, through the US Army Corps of Engineers, Engineer Research and Development Center, contract no. W9132T-05-C-0023. All protocols were approved by the Institutional Animal Care and Use Committee of Princeton University. NR 59 TC 30 Z9 30 U1 9 U2 28 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 0962-8452 J9 P R SOC B JI Proc. R. Soc. B-Biol. Sci. PD MAR 7 PY 2009 VL 276 IS 1658 BP 961 EP 969 DI 10.1098/rspb.2008.1277 PG 9 WC Biology; Ecology; Evolutionary Biology SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences & Ecology; Evolutionary Biology GA 400KS UT WOS:000262867100021 PM 19129135 ER PT J AU Loose, B McGillis, WR Schlosser, P Perovich, D Takahashi, T AF Loose, B. McGillis, W. R. Schlosser, P. Perovich, D. Takahashi, T. TI Effects of freezing, growth, and ice cover on gas transport processes in laboratory seawater experiments SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID SEA-ICE; CO2; EXCHANGE; OCEAN; FLUX AB Gas exchange through sea ice is a determining factor in the polar ocean budget of climatically-active gases. We use SF(6) and O(2) as conservative gas tracers to observe transport between the water, ice and air during conditions of freezing and partial ice cover in artificial seawater. During ice growth, O(2) and SF(6), as non-polar solutes, were rejected from the ice into the underlying water at a faster rate than that observed for salt. Measurements of the gas exchange rate, k, through partial ice cover exceeded that expected from linear scaling between 100% open water (k(100%)) and complete ice cover: at 15% open water, k was 25% of k(100%). These results indicate that the net flux of gas through the ice pack may not scale linearly with open water area, as circulation processes under the ice affect the gas exchange rate. Citation: Loose, B., W. R. McGillis, P. Schlosser, D. Perovich, and T. Takahashi (2009), Effects of freezing, growth, and ice cover on gas transport processes in laboratory seawater experiments, Geophys. Res. Lett., 36, L05603, doi:10.1029/2008GL036318. C1 [Loose, B.; McGillis, W. R.; Schlosser, P.; Takahashi, T.] Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY 10964 USA. [Perovich, D.] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Loose, B (reprint author), Columbia Univ, Lamont Doherty Earth Observ, 61 Route 9W, Palisades, NY 10964 USA. EM brice@ldeo.columbia.edu RI Schlosser, Peter/C-6416-2012 OI Schlosser, Peter/0000-0002-6514-4203 FU Climate Center at the Lamont-Doherty Earth Observatory; NSF [OPP 01-25523/ ANT 04-40825, OCE 5-25297, NOAA 5-62121] FX We would like to thank Jackie RichterMenge, Bruce Elder, Chris Polashenski, David Cole and David Ringelberg for their generous support of this work at CRREL. Bill Smethie, David Ho, and Eugene Gorman contributed to the design of the SF6 sampling and analysis procedures. Chris Zappa supported the ADV component of the study. Support for this work was provided by the Climate Center at the Lamont-Doherty Earth Observatory, an NSF IGERT Fellowship to BL, NSF grants OPP 01-25523/ ANT 04-40825 PS) and OCE 5-25297 WM), and NOAA 5-62121 WM). LDEO contribution 7234. NR 19 TC 51 Z9 52 U1 2 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD MAR 6 PY 2009 VL 36 AR L05603 DI 10.1029/2008GL036318 PG 5 WC Geosciences, Multidisciplinary SC Geology GA 415PT UT WOS:000263947200001 ER PT J AU Ogutu, BR Apollo, OJ McKinney, D Okoth, W Siangla, J Dubovsky, F Tucker, K Waitumbi, JN Diggs, C Wittes, J Malkin, E Leach, A Soisson, LA Milman, JB Otieno, L Holland, CA Polhemus, M Remich, SA Ockenhouse, CF Cohen, J Ballou, WR Martin, SK Angov, E Stewart, VA Lyon, JA Heppner, DG Withers, MR AF Ogutu, Bernhards R. Apollo, Odika J. McKinney, Denise Okoth, Willis Siangla, Joram Dubovsky, Filip Tucker, Kathryn Waitumbi, John N. Diggs, Carter Wittes, Janet Malkin, Elissa Leach, Amanda Soisson, Lorraine A. Milman, Jessica B. Otieno, Lucas Holland, Carolyn A. Polhemus, Mark Remich, Shon A. Ockenhouse, Christian F. Cohen, Joe Ballou, W. Ripley Martin, Samuel K. Angov, Evelina Stewart, V. Ann Lyon, Jeffrey A. Heppner, D. Gray, Jr. Withers, Mark R. CA MSP-1 Malaria Vaccine Working Grp TI Blood Stage Malaria Vaccine Eliciting High Antigen-Specific Antibody Concentrations Confers No Protection to Young Children in Western Kenya SO PLOS ONE LA English DT Article AB Objective: The antigen, falciparum malaria protein 1 (FMP1), represents the 42-kDa C-terminal fragment of merozoite surface protein-1 (MSP-1) of the 3D7 clone of P. falciparum. Formulated with AS02 (a proprietary Adjuvant System), it constitutes the FMP1/AS02 candidate malaria vaccine. We evaluated this vaccine's safety, immunogenicity, and efficacy in African children. Methods: A randomised, double-blind, Phase IIb, comparator-controlled trial. The trial was conducted in 13 field stations of one mile radii within Kombewa Division, Nyanza Province, Western Kenya, an area of holoendemic transmission of P. falciparum. We enrolled 400 children aged 12-47 months in general good health. Children were randomised in a 1: 1 fashion to receive either FMP1/AS02 (50 mu g) or Rabipur (R) rabies vaccine. Vaccinations were administered on a 0, 1, and 2 month schedule. The primary study endpoint was time to first clinical episode of P. falciparum malaria (temperature >= 37.5 degrees C with asexual parasitaemia of >= 50,000 parasites/mu L of blood) occurring between 14 days and six months after a third dose. Case detection was both active and passive. Safety and immunogenicity were evaluated for eight months after first immunisations; vaccine efficacy (VE) was measured over a six-month period following third vaccinations. Results: 374 of 400 children received all three doses and completed six months of follow-up. FMP1/AS02 had a good safety profile and was well-tolerated but more reactogenic than the comparator. Geometric mean anti-MSP-1(42) antibody concentrations increased from 1.3 mu g/mL to 27.3 mu g/mL in the FMP1/AS02 recipients, but were unchanged in controls. 97 children in the FMP1/AS02 group and 98 controls had a primary endpoint episode. Overall VE was 5.1% (95% CI: 226% to +28%; p-value = 0.7). Conclusions: FMP1/AS02 is not a promising candidate for further development as a monovalent malaria vaccine. Future MSP-142 vaccine development should focus on other formulations and antigen constructs. Trial Registration: Clinicaltrials. gov NCT00223990 C1 [Ogutu, Bernhards R.; Apollo, Odika J.; McKinney, Denise; Okoth, Willis; Siangla, Joram; Waitumbi, John N.; Otieno, Lucas; Polhemus, Mark; Remich, Shon A.; Martin, Samuel K.; Withers, Mark R.] USA, Med Res Unit Kenya, Nairobi, Kenya. [Ogutu, Bernhards R.; Apollo, Odika J.; McKinney, Denise; Okoth, Willis; Siangla, Joram; Waitumbi, John N.; Malkin, Elissa; Otieno, Lucas; Polhemus, Mark; Remich, Shon A.; Martin, Samuel K.; Withers, Mark R.] Kenya Govt Med Res Ctr, Ctr Clin Res, Nairobi, Kenya. [Dubovsky, Filip; Milman, Jessica B.] PATH Malaria Vaccine Initiative, Bethesda, MD USA. [Tucker, Kathryn; Wittes, Janet] Stat Collaborative Inc, Washington, DC USA. [Diggs, Carter; Soisson, Lorraine A.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC USA. [Leach, Amanda; Cohen, Joe; Ballou, W. Ripley; Heppner, D. Gray, Jr.] GlaxoSmithKline Biol sa, Rixensart, Belgium. [Holland, Carolyn A.; Ockenhouse, Christian F.; Angov, Evelina; Stewart, V. Ann; Lyon, Jeffrey A.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. RP Ogutu, BR (reprint author), USA, Med Res Unit Kenya, Nairobi, Kenya. EM bogutu@wrp-ksm.org RI Holland, Carolyn/B-7880-2011 FU PATH Malaria Vaccine Initiative (MVI); Malaria Vaccine Development Program (MVDP) of the US Agency for International Development (USAID); US Army Medical Research and Materiel Command (USAMRMC) FX The PATH Malaria Vaccine Initiative (MVI), the Malaria Vaccine Development Program (MVDP) of the US Agency for International Development (USAID), and the US Army Medical Research and Materiel Command (USAMRMC) provided funding. The three funding agencies were involved in all aspects of study design, data analysis, data interpretation, and writing of the report. The corresponding author had full access to all study data and had final responsibility for the decision to submit for publication. The study sponsor was the Office of the Surgeon General, US Army. NR 32 TC 134 Z9 136 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 5 PY 2009 VL 4 IS 3 AR e4708 DI 10.1371/journal.pone.0004708 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 437MC UT WOS:000265490600019 PM 19262754 ER PT J AU Koblmuller, G Metcalfe, GD Wraback, M Wu, F Gallinat, CS Speck, JS AF Koblmueller, G. Metcalfe, G. D. Wraback, M. Wu, F. Gallinat, C. S. Speck, J. S. TI In adlayer mediated molecular beam epitaxial growth and properties of a-plane InN on freestanding GaN SO APPLIED PHYSICS LETTERS LA English DT Article DE adsorbed layers; adsorption; energy gap; III-V semiconductors; indium compounds; molecular beam epitaxial growth; photoluminescence; plasma materials processing; reflection high energy electron diffraction; semiconductor epitaxial layers; semiconductor growth; stacking faults; surface roughness; wide band gap semiconductors ID MBE GROWTH; SAPPHIRE AB The role of the In adlayer on the morphological and structural properties of nonpolar a-plane InN films was elucidated during the plasma-assisted molecular beam epitaxy on freestanding GaN. Reflection high energy electron diffraction during In adsorption experiments on a-plane InN surfaces revealed a stable In adlayer coverage of similar to 2 ML. This In adlayer-mediated growth was responsible for achieving atomically smooth surfaces (rms roughness of < 1 nm), phase-pure material with lower x-ray rocking curve widths (Delta omega < 0.5 degrees), lower crystal mosaic tilt/twist, and decreased stacking fault densities, compared to N-rich conditions. The photoluminescence peak emission and band gap energy of the a-plane InN films were similar to 0.63 and similar to 0.7 eV, respectively. C1 [Koblmueller, G.; Wu, F.; Gallinat, C. S.; Speck, J. S.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. [Metcalfe, G. D.; Wraback, M.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Koblmuller, G (reprint author), Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. EM Gregor.Koblmueller@wsi.tum.de RI Gallinat, Chad/E-7561-2010; Speck, James/H-5646-2011; Wu, Feng/D-5641-2015 FU AFOSR; NSF FX The authors would like to thank C. Van de Walle for fruitful discussions and A. Hirai for the support with XRD analysis. This work was supported by AFOSR (D. J. Silversmith, program manager) and performed at the MRSEC facilities at UCSB (supported by NSF). NR 26 TC 23 Z9 23 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 2 PY 2009 VL 94 IS 9 AR 091905 DI 10.1063/1.3092482 PG 3 WC Physics, Applied SC Physics GA 423VF UT WOS:000264523100027 ER PT J AU Fazio, E Pettazzi, F Centini, M Chauvet, M Belardini, A Alonzo, M Sibilia, C Bertolotti, M Scalora, M AF Fazio, Eugenio Pettazzi, Federico Centini, Marco Chauvet, Mathieu Belardini, Alessandro Alonzo, Massimo Sibilia, Concita Bertolotti, Mario Scalora, Michael TI Complete spatial and temporal locking in phase-mismatched second-harmonic generation SO OPTICS EXPRESS LA English DT Article ID GROUP-VELOCITY DISPERSION; HARMONIC-GENERATION; FEMTOSECOND PULSES; LIGHT WAVES; BOUNDARY; LINBO3 AB We experimentally demonstrate simultaneous phase and group velocity locking of fundamental and generated second harmonic pulses in Lithium Niobate, under conditions of material phase mismatch. In phase-mismatched, pulsed second harmonic generation in addition to a reflected signal two forward-propagating pulses are also generated at the interface between a linear and a second order nonlinear material: the first pulse results from the solution of the homogeneous wave equation, and propagates at the group velocity expected from material dispersion; the second pulse is the solution of the inhomogeneous wave equation, is phase-locked and trapped by the pump pulse, and follows the pump trajectory. At normal incidence, the normal and phase locked pulses simply trail each other. At oblique incidence, the consequences can be quite dramatic. The homogeneous pulse refracts as predicted by material dispersion and Snell's law, yielding at least two spatially separate second harmonic spots at the medium's exit. We thus report the first experimental results showing that, at oblique incidence, fundamental and phase-locked second harmonic pulses travel with the same group velocity and follow the same trajectory. This is direct evidence that, at least up to first order, the effective dispersion of the phase-locked pulse is similar to the dispersion of the pump pulse. (C) 2009 Optical Society of America C1 [Fazio, Eugenio; Pettazzi, Federico; Centini, Marco; Belardini, Alessandro; Alonzo, Massimo; Sibilia, Concita; Bertolotti, Mario] Univ Roma La Sapienza, Dipartimento Energet, Ultrafast Photon Lab, I-00161 Rome, Italy. [Fazio, Eugenio; Pettazzi, Federico; Centini, Marco; Belardini, Alessandro; Alonzo, Massimo; Sibilia, Concita; Bertolotti, Mario] Univ Roma La Sapienza, CNISM, I-00161 Rome, Italy. [Chauvet, Mathieu] Univ Franche Comte, CNRS, UMR 6174, Inst FEMTO ST,Dept Opt, F-25030 Besancon, France. [Scalora, Michael] USA, RDECOM, Charles M Bowden Res Facil, Aviat & Missile Command, Redstone Arsenal, AL 35803 USA. RP Fazio, E (reprint author), Univ Roma La Sapienza, Dipartimento Energet, Ultrafast Photon Lab, Via Scarpa 16, I-00161 Rome, Italy. EM eugenio.fazio@uniroma1.it OI FAZIO, Eugenio/0000-0002-0995-0702; BELARDINI, ALESSANDRO/0000-0002-7574-0332; CENTINI, MARCO/0000-0003-0625-0054 FU National PRIN-05; La Sapienza University FX This work has been partially supported by the National PRIN-05 project "sorgenti e amplificatori laser in guide solitoniche in niobato di litio"; Mathieu Chauvet was partially supported by La Sapienza University with the project "professori visitatori". A. M. D. G. NR 21 TC 25 Z9 25 U1 1 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAR 2 PY 2009 VL 17 IS 5 BP 3141 EP 3147 DI 10.1364/OE.17.003141 PG 7 WC Optics SC Optics GA 417QJ UT WOS:000264090900013 PM 19259150 ER PT J AU Chen, G Xu, ZY Ding, HP Sadler, BM AF Chen, Gang Xu, Zhengyuan Ding, Haipeng Sadler, Brian M. TI Path loss modeling and performance trade-off study for short-range non-line-of-sight ultraviolet communications SO OPTICS EXPRESS LA English DT Article ID LIGHT-EMITTING-DIODES; AVALANCHE PHOTODIODES AB We consider outdoor non-line-of-sight deep ultraviolet (UV) solar blind communications at ranges up to 100 m, with different transmitter and receiver geometries. We propose an empirical channel path loss model, and fit the model based on extensive measurements. We observe range-dependent power decay with a power exponent that varies from 0.4 to 2.4 with varying geometry. We compare with the single scattering model, and show that the single scattering assumption leads to a model that is not accurate for small apex angles. Our model is then used to study fundamental communication system performance trade-offs among transmitted optical power, range, link geometry, data rate, and bit error rate. Both weak and strong solar background radiation scenarios are considered to bound detection performance. These results provide guidelines to system design. (C) 2009 Optical Society of America C1 [Chen, Gang; Xu, Zhengyuan; Ding, Haipeng] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] AMSRD ARL CI NT, US Army Res Lab, Adelphi, MD 20783 USA. RP Xu, ZY (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu RI Ding, Haipeng/B-7742-2014 FU Army Research Office [W911NF-06-1-0364, W911NF-08-1-0163, W911NF-06-1-0173]; Army Research Laboratory under the Collaborative Technology Alliance Program [DAAD19-01-2-0011] FX The authors would like to thank Qunfeng He for his invaluable help with experiments. This work was supported in part by the Army Research Office under Grants W911NF-06-1-0364, W911NF-08-1-0163, and W911NF-06-1-0173, and the Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. NR 22 TC 86 Z9 100 U1 0 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAR 2 PY 2009 VL 17 IS 5 BP 3929 EP 3940 DI 10.1364/OE.17.003929 PG 12 WC Optics SC Optics GA 417QJ UT WOS:000264090900097 PM 19259234 ER PT J AU Fernhall, B Baynard, T Collier, SR Figueroa, A Goulopoulou, S Kamimori, GH Pitetti, KH AF Fernhall, Bo Baynard, Tracy Collier, Scott R. Figueroa, Arturo Goulopoulou, Styliani Kamimori, Gary H. Pitetti, Kenneth H. TI Catecholamine Response to Maximal Exercise in Persons With Down Syndrome SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID HEART-RATE RESPONSE; MENTAL-RETARDATION; INDIVIDUALS; ADOLESCENTS; RELIABILITY; CHILDREN; FITNESS; ADULTS AB Individuals with Down syndrome (DS) exhibit low peak aerobic capacities and heart rates. Although autonomic modulation is attenuated in individuals with DS at rest, the exercise response appears normal. This suggests that mechanisms other than autonomic control influence the low aerobic capacity, such as catecholamine responsiveness to exercise. The purpose of this study was to determine catecholamine responses to a peak treadmill test in a group of subjects with DS compared with a nondisabled group. Epinephrine and norepinephrine concentrations were measured at rest and immediately after graded exercise tests on a treadmill in 20 subjects with DS (mean age, 24 7 years) and 21 nondisabled subjects (mean age, 26 6 years). Catecholamines increased significantly with peak exercise in the control group (p <0.05), with little to no change in subjects with DS. In conclusion, the different catecholamine responses to peak exercise, in particular the lack of a response in individuals with the DS, may be a primary mechanism to explain the reduced peak heart: rates and low work capacities observed in this population. (C) 2009 Elsevier Inc. (Am J Cardiol 2009;103:724-726) C1 [Fernhall, Bo; Baynard, Tracy] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA. [Fernhall, Bo; Baynard, Tracy; Collier, Scott R.; Figueroa, Arturo; Goulopoulou, Styliani] Syracuse Univ, Dept Exercise Sci, Syracuse, NY USA. [Figueroa, Arturo] Florida State Univ, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32306 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. [Pitetti, Kenneth H.] Wichita State Univ, Dept Phys Therapy, Wichita, KS USA. RP Fernhall, B (reprint author), Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA. EM fernhall@illinois.edu OI Baynard, Tracy/0000-0002-5150-4095 NR 15 TC 37 Z9 37 U1 0 U2 1 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD MAR 1 PY 2009 VL 103 IS 5 BP 724 EP 726 DI 10.1016/j.amjcard.2008.10.036 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 416DV UT WOS:000263986500027 PM 19231341 ER PT J AU Yetley, EA Brule, D Cheney, MC Davis, CD Esslinger, KA Fischer, PWF Friedl, KE Greene-Finestone, LS Guenther, PM Klurfeld, DM L'Abbe, MR McMurry, KY Starke-Reed, PE Trumbo, PR AF Yetley, Elizabeth A. Brule, Danielle Cheney, Margaret C. Davis, Cindy D. Esslinger, Krista A. Fischer, Peter W. F. Friedl, Karl E. Greene-Finestone, Linda S. Guenther, Patricia M. Klurfeld, David M. L'Abbe, Mary R. McMurry, Kathryn Y. Starke-Reed, Pamela E. Trumbo, Paula R. TI Dietary Reference Intakes for vitamin D: justification for a review of the 1997 values SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID CURRENT DILEMMAS; RESEARCH NEEDS; HEALTH; CANCER AB Recent Institute of Medicine (IOM) reviews of the process for deriving Dietary Reference Intakes (DRIs) suggest that determining the need for a new nutrient review should be evaluated against criteria set a priori. After selecting the criterion of significant new and relevant research, a working group of US and Canadian government scientists used results from a systematic review and 2 conferences on vitamin D and health to evaluate whether significant new and relevant scientific evidence had become available since the 1997 IOM publication of the DRIs for vitamin D. This working group concluded that there appears to be new research meeting the criteria for 4 key DRI questions. The new research is of larger quantity and quality for the elderly than for other groups, but overall 1) adds to the bone-related and status evidence available to the 1997 DRI Committee for several of the life-stage groups, 2) identifies new outcomes with respect to risk of falls and performance measures in the elderly and potential adverse effects, and 3) provides additional information on dose-response relations between intakes and circulating 25-hydroxyvitamin D concentrations and between 25-hydroxyvitamin D concentrations and several health outcomes (ie, bone-related outcomes for all ages and risk of falls and performance measures in older adults). Members of the working group concluded that significant new and relevant research was available for reviewing the existing DRIs for vitamin D while leaving the decision of whether the new research will result in changes to the current DRIs to a future IOM-convened DRI committee. Am J Clin Nutr 2009; 89: 719-27. C1 [Yetley, Elizabeth A.] Off Dietary Supplements, NIH, Bethesda, MD 20892 USA. [Klurfeld, David M.] Agr Res Serv, USDA, Washington, DC USA. [Guenther, Patricia M.] USDA, Ctr Nutr Policy & Promot, Washington, DC 20250 USA. [Friedl, Karl E.] USA, Med Res & Mat Command, Ft Detrick, MD USA. [Fischer, Peter W. F.; L'Abbe, Mary R.] Hlth Canada, Bur Nutr Sci, Food Directorate, Ottawa, ON K1A 0L2, Canada. [Brule, Danielle; Cheney, Margaret C.; Esslinger, Krista A.] Hlth Canada, Off Nutr Policy & Promot, Ottawa, ON K1A 0L2, Canada. [Trumbo, Paula R.] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD USA. [Starke-Reed, Pamela E.] NIH, Div Nutr Res Coordinat, Bethesda, MD 20892 USA. [Davis, Cindy D.] NCI, NIH, Bethesda, MD 20892 USA. [McMurry, Kathryn Y.] US Dept Hlth & Human Serv, Off Dis Prevent & Hlth Promot, Washington, DC USA. [Greene-Finestone, Linda S.] Publ Hlth Agcy Canada, Ottawa, ON, Canada. RP Yetley, EA (reprint author), Off Dietary Supplements, NIH, 6100 Executive Blvd,Room 3B01, Bethesda, MD 20892 USA. EM beth@yetley.com OI Friedl, Karl/0000-0002-3134-8427 NR 20 TC 36 Z9 39 U1 0 U2 1 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAR 1 PY 2009 VL 89 IS 3 BP 719 EP 727 DI 10.3945/ajcn.2008.26903 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 410IS UT WOS:000263571300001 PM 19176741 ER PT J AU Combest, T Forster, CPTC Kumar, H Pinholt, COLE AF Combest, Travis Forster, C. P. T. Christopher Kumar, Harjinder Pinholt, C. O. L. Ellen TI Outcomes of Stages of Change for Physical Activity in a Falls Prevention Clinic SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Meeting Abstract C1 [Combest, Travis; Forster, C. P. T. Christopher; Kumar, Harjinder; Pinholt, C. O. L. Ellen] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-7481 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD MAR PY 2009 VL 17 IS 3 SU 1 BP A94 EP A95 PG 2 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA V16YW UT WOS:000207905900125 ER PT J AU Laramee, JA Durst, HD Nilles, JM Connell, TR AF Laramee, James A. Durst, H. Dupont Nilles, J. Michael Connell, Theresa R. TI Alcohols Can Now Be Analyzed by a Direct Analysis in Real-Time Method: Applications for Chemical Warfare Agent Synthesis SO AMERICAN LABORATORY LA English DT Article C1 [Laramee, James A.] SAIC, Aberdeen Proving Ground, MD 21010 USA. [Durst, H. Dupont] USA, Edgewood Chem Biol Ctr, Chem Methodol Team, Aberdeen Proving Ground, MD USA. [Nilles, J. Michael; Connell, Theresa R.] Sci & Engn Technol Inc, Springfield, VA USA. RP Laramee, JA (reprint author), SAIC, Box 68, Aberdeen Proving Ground, MD 21010 USA. EM james.a.laramee@us.army.mil NR 4 TC 8 Z9 9 U1 2 U2 9 PU INT SCIENTIFIC COMMUN INC PI SHELTON PA PO BOX 870, 30 CONTROLS DRIVE, SHELTON, CT 06484-0870 USA SN 0044-7749 J9 AM LAB JI Am. Lab. PD MAR PY 2009 VL 41 IS 4 BP 24 EP + PG 3 WC Chemistry, Analytical; Instruments & Instrumentation SC Chemistry; Instruments & Instrumentation GA 422WA UT WOS:000264457200005 ER PT J AU Capacchione, JF Radimer, MC Sagel, JS Kraus, GP Sambuughin, N Muldoon, SM AF Capacchione, John F. Radimer, Matthew C. Sagel, Jeffrey S. Kraus, Gregory P. Sambuughin, Nyamkhishig Muldoon, Sheila M. TI Trauma, Systemic Inflammatory Response Syndrome, Dietary Supplements, Illicit Steroid Use and a Questionable Malignant Hyperthermia Reaction SO ANESTHESIA AND ANALGESIA LA English DT Article ID EXERCISE-INDUCED RHABDOMYOLYSIS; SKELETAL-MUSCLE; SARCOPLASMIC-RETICULUM; CALCIUM-RELEASE; NEUROMUSCULAR DISEASES; ANABOLIC-STEROIDS; CONTRACTURE TEST; RENAL-FAILURE; HALOTHANE; CAFFEINE AB BACKGROUND: Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle calcium regulation associated primarily, but not exclusively, with mutations in the skeletal muscle ryanodine receptor. Associated environmental factors, however, may also be important for expression of the syndrome. METHODS AND RESULTS: A 24-yr-old trauma patient developed a fulminant MH crisis after a 3 minute exposure to sevoflurane. A thorough evaluation of underlying co-morbidities revealed a number of environmental factors that could have altered skeletal muscle calcium regulation, and may have potentially influenced the effects of volatile inhaled anesthetics. Since MH is a syndrome characterized by abnormal skeletal muscle calcium regulation, other factors that alter calcium homeostasis may exacerbate the impact of inhaled lull-l-triggering drugs. CONCLUSIONS: While a thorough history of MH episodes in a proband and family is emphasized as part of a complete preanesthetic evaluation, obtaining a history of other environmental entities that may alter calcium regulation may be equally important to knowing the family history. C1 [Capacchione, John F.; Radimer, Matthew C.; Sagel, Jeffrey S.; Kraus, Gregory P.; Sambuughin, Nyamkhishig; Muldoon, Sheila M.] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD 20814 USA. RP Capacchione, JF (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Walter Reed Army Med Ctr, Natl Naval Med Ctr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM jcapacchione@usuhs.mil FU Department of Anesthesiology, Uniformed Services University of the Health Sciences FX Supported by Department of Anesthesiology, Uniformed Services University of the Health Sciences. NR 40 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD MAR PY 2009 VL 108 IS 3 BP 900 EP 903 DI 10.1213/ane.0b013e31819240a5 PG 4 WC Anesthesiology SC Anesthesiology GA 409WU UT WOS:000263537300036 PM 19224800 ER PT J AU Bland, CM Thomas, S AF Bland, Christopher M. Thomas, Sanil TI Micafungin plus Fluconazole in an Infected Knee with Retained Hardware due to Candida albicans SO ANNALS OF PHARMACOTHERAPY LA English DT Article DE albicans; biofilm; fluconazole; joint; micafungin; prosthetic ID ANTIFUNGAL AGENTS; AMPHOTERICIN-B; BIOFILMS; CASPOFUNGIN; ECHINOCANDINS; ARTHROPLASTY; FLUCYTOSINE; AZOLE AB OBJECTIVE: To describe the use of micafungin and fluconazole in the management of a fungal prosthetic joint infection caused by Candida albicans. CASE SUMMARY: A 55-year-old female who had undergone total left knee arthroplasty due to rheumatoid arthritis presented with symptoms of a left knee infection. Intravenous vancomycin 1 g every 12 hours and intravenous ampicillin/sulbactam 1.5 g every 6 hours were initiated. Arthrocentesis produced cloudy synovial fluid with a white blood cell (WBC) count of 5.995 x 10(3)/mu L. C-reactive protein (CRP) was 19.8 mg/dL and erythrocyte sediment rate (ESR) was greater than 120 mm/h. Gram stain was negative, but intraoperative cultures grew C. albicans. Four days later the patient's condition worsened and repeat arthrocentesis showed WBC count of 16.8 x 10(3)/mu L with budding yeast in the synovial fluid. Antibiotics were stopped and liposomal amphotericin B 5 mg/kg once daily was started but was stopped after a few doses due to renal failure. Intravenous micafungin 100 mg daily was initiated; intravenous fluconazole 400 mg daily was added 2 days later and subsequently changed to oral fluconazole after 2 days of therapy. The patient received combination micafungin/fluconazole therapy for 8 weeks. After approximately 8 weeks of therapy, the CRP level and ESR had decreased from 19.8 to 7.1 mg/dL and greater than 120 to 81 mm/h, respectively. The patient's pain and range of motion in her knee had returned to baseline levels at last follow-up after the total knee arthroplasty. After 8 weeks of combination therapy, micafungin was discontinued but oral fluconazole was continued; approximately 8 weeks later the patient relapsed, requiring removal of the prosthetic knee hardware. DISCUSSION: Fungal prosthetic joint infections are rare, but definitive data regarding appropriate treatment are lacking. Echinocandins are an attractive treatment option due to their enhanced biofilm penetration. In our patient, treatment with micafungin plus fluconazole for 8 weeks followed by fluconazole monotherapy was associated with an initial good outcome in the treatment of a C. albicans prosthetic knee infection with retained hardware. This was, to our knowledge, the first case using micafungin in a prosthetic joint infection. CONCLUSIONS: Although micafungin plus fluconazole showed positive results in our patient, more data are needed regarding combination therapy for fungal prosthetic joint infections. C1 [Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Dept Clin Pharm, Ft Gordon, GA 30905 USA. [Thomas, Sanil] Dwight D Eisenhower Army Med Ctr, Dept Infect Dis, Ft Gordon, GA 30905 USA. RP Bland, CM (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Clin Pharm, Hosp Rd Bldg 300, Ft Gordon, GA 30905 USA. EM chris.bland@us.army.mil NR 17 TC 6 Z9 9 U1 0 U2 3 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 USA SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD MAR PY 2009 VL 43 IS 3 BP 528 EP 531 DI 10.1345/aph.1L508 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 419IK UT WOS:000264212700015 PM 19261955 ER PT J AU Ellsworth, DL Ellsworth, RE Hooke, JA Shriver, CD AF Ellsworth, Darrell L. Ellsworth, Rachel E. Hooke, Jeffrey A. Shriver, Craig D. TI Reply to "Human Genetic and Structural Genomic Variation: Would Genomewide Association Studies be the Solution of Cancer Complexity Like Alexander the Great for the 'Gordian Knot'?" SO ANNALS OF SURGICAL ONCOLOGY LA English DT Letter ID BREAST-CANCER; WIDE ASSOCIATION; RISK C1 [Ellsworth, Darrell L.] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. [Ellsworth, Rachel E.] Henry M Jackson Fdn Advancement Mil Med, Clin Breast Care Project, Windber, PA 15963 USA. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. RP Ellsworth, DL (reprint author), Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. EM d.ellsworth@wriwindber.org NR 10 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD MAR PY 2009 VL 16 IS 3 BP 776 EP 777 DI 10.1245/s10434-008-0255-x PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 407GN UT WOS:000263351700032 ER PT J AU Happi, CT Gbotosho, GO Folarin, OA Sowunmi, A Hudson, T O'Neil, M Milhous, W Wirth, DF Oduola, AMJ AF Happi, C. T. Gbotosho, G. O. Folarin, O. A. Sowunmi, A. Hudson, T. O'Neil, M. Milhous, W. Wirth, D. F. Oduola, A. M. J. TI Selection of Plasmodium falciparum Multidrug Resistance Gene 1 Alleles in Asexual Stages and Gametocytes by Artemether-Lumefantrine in Nigerian Children with Uncomplicated Falciparum Malaria SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLUS SULFADOXINE-PYRIMETHAMINE; PFMDR1 GENE; CHLOROQUINE RESISTANCE; INCREASED SENSITIVITY; PLASMODIUM-FALCIPARUM-PFMDR1 ALLELES; AMODIAQUINE RESISTANCE; COMBINATION THERAPY; TANZANIAN CHILDREN; DRUG-RESISTANCE; POINT MUTATIONS AB We assessed Plasmodium falciparum mdr1 (Pfmdr1) gene polymorphisms and copy numbers as well as P. falciparum Ca(2+) ATPase (PfATPase6) gene polymorphisms in 90 Nigerian children presenting with uncomplicated falciparum malaria and enrolled in a study of the efficacy of artemether-lumefantrine (AL). The nested PCR-restriction fragment length polymorphism and the quantitative real-time PCR methodologies were used to determine the alleles of the Pfmdr1 and PfATPase6 genes and the Pfmdr1 copy number variation, respectively, in patients samples collected prior to treatment and at the reoccurrence of parasites during a 42-day follow-up. The Pfmdr1 haplotype 86N-184F-1246D was significantly associated (P < 0.00001) with treatment failures and was selected for among posttreatment samples obtained from patients with newly acquired or recrudescing infections (P < 0.00001; chi(2) = 36.5) and in gametocytes (log rank statistic = 5; P = 0.0253) after treatment with AL. All pre- and posttreatment samples as well as gametocytes harbored a single copy of the Pfmdr1 gene and the wild-type allele (L89) at codon 89 of the PfATPase6 gene. These findings suggest that polymorphisms in the Pfmdr1 gene are under AL selection pressure. Pfmdr1 polymorphisms may result in reduction in the therapeutic efficacy of this newly adopted combination treatment for uncomplicated falciparum malaria in Saharan countries of Africa. C1 [Happi, C. T.; Gbotosho, G. O.; Folarin, O. A.; Sowunmi, A.] Univ Ibadan, Malaria Res Labs, IMRAT, Coll Med, Ibadan, Nigeria. [Happi, C. T.; Wirth, D. F.] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA. [Hudson, T.; O'Neil, M.; Milhous, W.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Oduola, A. M. J.] Special Programme Res & Training Trop Dis WHO TDR, Geneva, Switzerland. RP Happi, CT (reprint author), Univ Ibadan, Malaria Res Labs, IMRAT, Coll Med, Ibadan, Nigeria. EM chappi@hsph.harvard.edu RI Hudson, Thomas/A-9152-2011 FU Fogarty International Center; Multilateral Initiative for Malaria in Africa (MIM)/TDR; UNICEF/UNDP/World Bank/WHO/TDR; Harvard Malaria Initiative; EDCTP; International Atomic Energy Agency (IAEA); Fogarty International Research Collaboration [NIH RO3TW007757-02]; IAEA [RAF/0625]; UNICEF/UNDP/World Bank/WHO/TDR/PAG/South-South Initiative [ID A50337]; European Union; Developing Countries Clinical Trial Partnership (EDCTP) [TA.2007.40200]; MIM/TDR [ID A20239]; Pfizer Global Pharmaceutical Grant FX We thank all the patients and their parents or guardians for volunteering to participate in the study. We thank the Malaria Research and Reference Reagent Resource Centre (MR4) for providing the genomic DNA used as controls for the PCR and RFLP experiments. We also thank Sarah Volkman at the Harvard School of Public Health for providing us with the Plasmodium falciparum W2mef strain for Pfmdr1 copy number analysis.; This study was supported by grants from the Fogarty International Center, the Multilateral Initiative for Malaria in Africa (MIM)/TDR, UNICEF/UNDP/World Bank/WHO/TDR, the Harvard Malaria Initiative, EDCTP, and the International Atomic Energy Agency (IAEA). C. T. Happi is supported by Fogarty International Research Collaboration award no. NIH RO3TW007757-02, IAEA project RAF/0625, UNICEF/UNDP/World Bank/WHO/TDR/PAG/South-South Initiative project ID A50337, and European Union and Developing Countries Clinical Trial Partnership (EDCTP) award no. TA.2007.40200. 016 for a senior research fellowship. G. O. Gbotosho is supported by MIM/TDR project ID A20239. A. Sowunmi is supported by a Pfizer Global Pharmaceutical Grant.; None of the authors has a conflict of interest to declare. NR 39 TC 57 Z9 57 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2009 VL 53 IS 3 BP 888 EP 895 DI 10.1128/AAC.00968-08 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 410BY UT WOS:000263552100006 PM 19075074 ER PT J AU Gupta, N AF Gupta, Neelam TI Investigation of a mercurous chloride acousto-optic cell based on longitudinal acoustic mode SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT 10th International Spring School on Acousto-Optics CY MAY, 2008 CL Sopot, POLAND ID TUNABLE FILTER; PERFORMANCE; REGION; CRYSTALS; DEVICES AB A number of spectral imagers using acousto-optic tunable filters (AOTFs) operating from the UV to the long-wave infrared (LWIR) using KDP, MgF2, TeO2, and Tl3AsSe3 crystals to cover different Spectral regions have been developed. In the LWIR there is a lack of high quality acousto-optic (AO) materials Mercurous halide (Hg2Cl2, and Hg2Br2) crystals are highly anisotropic with a high AO figure of merit due to slow acoustic velocities and high photoelastic constants and are transparent over a wide spectral region from 0.35 to 20 mu m for Hg2Cl2 and from 0.4 to 30 mu m for Hg2Br2. AO modulators, deflectors, and AOTFs based on these crystals can operate over a wide spectral range. Single crystals of these materials are being grown and some prototype devices have been fabricated. Results are presented from device characterization for an AO cell fabricated in Hg2Cl2 based on longitudinal acoustic mode propagation. This device was very useful in demonstrating the AO interaction as well as soundness of the transducer bonding technique. Acoustic phase velocity is calculated and measured, diffraction efficiency is obtained from experiments, and the AO figure of merit of the sample is evaluated. (C) 2009 Optical Society of America C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Gupta, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Gupta, Neelam/B-8702-2013 NR 36 TC 5 Z9 5 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAR 1 PY 2009 VL 48 IS 7 BP C151 EP C158 DI 10.1364/AO.48.00C151 PG 8 WC Optics SC Optics GA 422FT UT WOS:000264413600021 PM 19252608 ER PT J AU Herr, MW Williams, SB Cable, BB AF Herr, Marc W. Williams, Stephen B. Cable, Benjamin B. TI Pathology Quiz Case 1 Diagnosis: Salivary gland anlage tumor (SGAT) SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material ID CONGENITAL PLEOMORPHIC ADENOMA; NASOPHARYNX C1 [Herr, Marc W.; Williams, Stephen B.; Cable, Benjamin B.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Herr, MW (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD MAR PY 2009 VL 135 IS 3 BP 320 EP + PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 419KP UT WOS:000264218600018 PM 19289716 ER PT J AU East, EW Martinez, JC Kirby, JG AF East, E. William Martinez, Julio C. Kirby, Jeffrey G. TI Discrete-event simulation based performance quantification of web-based and traditional bidder inquiry processes SO AUTOMATION IN CONSTRUCTION LA English DT Article DE Bidder inquiry; Collaboration; Business process; Discrete-event simulation; Stroboscope; Verification; Validation ID CONSTRUCTION AB This paper describes an innovative application of discrete-event simulation to model and evaluate differences in business processes following the introduction of new information technologies. Validated models can be used by offices considering the new technology to calibrate existing work loads and then to predict the expected impact of new information technology on measurable business metrics. Following the introduction of the technology, this model may assist in the real-time verification of user paths incorporated in software support tools. This paper will be of interest to those evaluating the impact of information technology and public construction contract administration. Published by Elsevier B.V. C1 [East, E. William; Kirby, Jeffrey G.] Engn Res & Dev Ctr, Champaign, IL 61826 USA. [Martinez, Julio C.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA. RP East, EW (reprint author), Engn Res & Dev Ctr, Champaign, IL 61826 USA. EM bill.east@us.army.mil; julio@purdue.edu; jeffrey.g.kirby@rdc.usace.army.mil NR 15 TC 7 Z9 8 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-5805 J9 AUTOMAT CONSTR JI Autom. Constr. PD MAR PY 2009 VL 18 IS 2 BP 109 EP 117 DI 10.1016/j.autcon.2008.05.003 PG 9 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 401QH UT WOS:000262956200002 ER PT J AU Matyas, GR Beck, Z Karasawas, N Alving, CR AF Matyas, Gary R. Beck, Zoltan Karasawas, Nicos Alving, Carl R. TI Lipid binding properties of 4E10, 2175, and WR304 monoclonal antibodies that neutralize HIV-1 SO BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES LA English DT Article DE HIV-1; Antibody; Phospholipid; Cholesterol; Glycolipid; Lipid A ID IMMUNODEFICIENCY-VIRUS TYPE-1; PHOSPHATIDYLINOSITOL PHOSPHATE; MEMBRANE; 2F5; LIPOSOMES; EPITOPE; GP41; AUTOREACTIVITY; PROTEIN; SPECIFICITIES AB Two human mAbs (25 and 4E10), originally derived from HIV-1-infected patients, are important, but rare, mAbs that exhibit broad cross-clade neutralizing activities against HIV-1. In addition to peptide sequences on the gp41 envelope protein, both antibodies reportedly also bound specifically to several phospholipid antigens. However, the phospholipid binding property of 2175 has been disputed and, because of uncertainly regarding phospholipid binding, the modeling of neutralizing mechanisms has been difficult To explore this issue, we examined the binding of 4E10 and 2175 to a broad range of lipid antigens by ELISA. 4E10 and 2F5 both bound to a variety of purified phospholipids, and 4E10 bound, but 2F5 did not bind, to cardiolipin. Both mAbs also bound to a sulfated glycolipid, sulfogalactosyl ceramide (sulfatide), and to two neutral glycolipids, galactosyl ceramide and glucosyl ceramide, but not to other galactosyl glycolipids. 4E10, but not 2175, also bound to cholesterol, although both mAbs bound to squalene. Interestingly, 4E10, but not 2F5, exhibited striking binding to lipid A, the lipid moiety of Gram-negative bacterial lipopolysaccharide. The binding properties of 4E10 to phospholipids, sulfatide, cholesterol, squalene, and lipid A were similar to those of a neutralizing murine mAb (WR304) induced by liposomes containing phosphatidylinositol phosphate and lipid A, although WR304 did not bind to neutral glycolipids. The discovery of a binding specificity of 4E10 for lipid A, a widely used vaccine adjuvant, suggests that innate immunity stimulated by lipid A could have played a role for induction of multispecific antibodies that simultaneously recognize both HIV-1 protein and lipid antigens. (C) 2008 Elsevier B.V. All rights reserved. C1 [Matyas, Gary R.; Beck, Zoltan; Karasawas, Nicos; Alving, Carl R.] Walter Reed Army Med Ctr, US Mil HIV Res Program, Div Retrovirol, Dept Adjuvant & Antigen Res, Rockville, MD 20850 USA. [Beck, Zoltan] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA. RP Matyas, GR (reprint author), Walter Reed Army Med Ctr, US Mil HIV Res Program, Div Retrovirol, Dept Adjuvant & Antigen Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM gmatyas@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; U.S. Army Medical Research and Material Command FX We thank Tam Dinh, Francis Owusu, and Tiffany Hodges for their excellent technical assistance. This work was supported through cooperative agreement contract no. W81XWH-07-2-0067 between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Material Command, working together with the Division of AIDS, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, MD. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. The views and opinions expressed herein are the private opinions of the authors and do not necessarily reflect the views of the U.S. Army or the U.S. Department of Defense. NR 29 TC 46 Z9 46 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0005-2736 J9 BBA-BIOMEMBRANES JI Biochim. Biophys. Acta-Biomembr. PD MAR PY 2009 VL 1788 IS 3 BP 660 EP 665 DI 10.1016/j.bbamem.2008.11.015 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 420EJ UT WOS:000264271400009 PM 19100711 ER PT J AU Parnell, GS Borio, LL Cox, LA Brown, GG Pollock, S Wilson, AG AF Parnell, Gregory S. Borio, Luciana L. Cox, Louis A. (Tony) Brown, Gerald G. Pollock, Stephen Wilson, Alyson G. TI PROBABILISTIC RISK ANALYSIS AND BIOTERRORISM RISK RESPONSE SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Editorial Material C1 [Parnell, Gregory S.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Borio, Luciana L.] Johns Hopkins Univ, Baltimore, MD USA. [Cox, Louis A. (Tony)] Cox Associates, Denver, CO USA. [Cox, Louis A. (Tony)] Univ Colorado, Hlth Sci Ctr, Denver, CO USA. [Brown, Gerald G.] USN, Postgrad Sch, Dept Operat Res, Monterey, CA USA. [Pollock, Stephen] Univ Michigan, Dept Ind & Operat Engn, Ann Arbor, MI 48109 USA. [Wilson, Alyson G.] Iowa State Univ, Dept Stat, Ames, IA USA. RP Parnell, GS (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM gregory.parnell@usma.edu NR 9 TC 2 Z9 2 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 EI 1557-850X J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD MAR PY 2009 VL 7 IS 1 BP 111 EP 112 DI 10.1089/bsp.2009.0927 PG 2 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 434ZA UT WOS:000265311600011 ER PT J AU Enewold, L Zhu, KM Ron, E Marrogi, AJ Stojadinovic, A Peoples, GE Devesa, SS AF Enewold, Lindsey Zhu, Kangmin Ron, Elaine Marrogi, Aizen J. Stojadinovic, Alexander Peoples, George E. Devesa, Susan S. TI Rising Thyroid Cancer Incidence in the United States by Demographic and Tumor Characteristics, 1980-2005 SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID INCREASING INCIDENCE; REPRODUCTIVE FACTORS; POOLED ANALYSIS; TIME TRENDS; CARCINOMA; PAPILLARY; EXPOSURE; RISK; RADIATION; EPIDEMIC AB Thyroid cancer incidence has been rising in the United States, and this trend has often been attributed to heightened medical surveillance and the use of improved diagnostics. Thyroid cancer incidence varies by sex and race/ethnicity, and these factors also influence access to and utilization of healthcare. We therefore examined thyroid cancer incidence rates by demographic and tumor characteristics based on 48,403 thyroid cancer patients diagnosed during 1980-2005 from the Surveillance, Epidemiology and End Results program of the National Cancer Institute. The rates varied by histologic type, sex, and race/ethnicity. Papillary carcinoma was the only histologic type for which incidence rates increased consistently among all racial/ethnic groups. Subsequent analyses focused on the 39,706 papillary thyroid cancers diagnosed during this period. Papillary carcinoma rates increased most rapidly among females. Between 1992-1995 and 2003-2005, they increased nearly 100% among White non-Hispanics and Black females but only 20% to 50% among White Hispanics, Asian/Pacific Islanders, and Black males. The increases were most rapid for localized stage and small tumors; however, rates also increased for large tumors and tumors of regional and distant stage. Since 1992-1995, half the overall increase in papillary carcinoma rates was due to increasing rates of very small (<= 1.0 cm) cancers, 30% to cancers 1.1 to 2 cm, and 20% to cancers >2 cm. Among White females, the rate of increase for cancers >5 cm almost equaled that for the smallest cancers. Medical surveillance and more sensitive diagnostic procedures cannot completely explain the observed increases in papillary thyroid cancer rates. Thus, other possible explanations should be explored. (Cancer Epidemiol Biomarkers Prev 2009;18(3):784-91) C1 [Ron, Elaine; Devesa, Susan S.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Houston, TX USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Marrogi, Aizen J.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Marrogi, Aizen J.] Walter Reed Army Med Ctr, Area Lab Serv, Washington, DC 20307 USA. [Enewold, Lindsey; Zhu, Kangmin; Marrogi, Aizen J.; Stojadinovic, Alexander; Peoples, George E.] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. RP Enewold, L (reprint author), Armed Forces Inst Pathol, US Mil Canc Inst, Room N1512,Bldg 54,6825 16th St NW, Washington, DC 20306 USA. EM Lindsey.Enewold@us.army.mil FU Division of Cancer Epidemiology and Genetics Intramural Research Program; National Cancer Institute; NIH; Department of Health and Human Services; United States Military Cancer Institute FX Division of Cancer Epidemiology and Genetics Intramural Research Program, National Cancer Institute, NIH, Department of Health and Human Services and the United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine. The information or content and conclusions do not necessarily represent the official position or policy of, nor should any official endorsement be inferred by, the Uniformed Services University of the Health Sciences, the United States Military Cancer Institute, the Department of Defense, or the U.S. Government. NR 44 TC 325 Z9 352 U1 2 U2 13 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD MAR PY 2009 VL 18 IS 3 BP 784 EP 791 DI 10.1158/1055-9965.EPI-08-0960 PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 419NK UT WOS:000264226100015 PM 19240234 ER PT J AU Kessler, CM Cap, AP AF Kessler, Craig M. Cap, Andrew P. TI Prevention of Venous Thromboembolism in Hospitalized Medical Patients SO CANCER INVESTIGATION LA English DT Article DE Venous Thromboembolism; Hospitalized Medical Patients; Primary Prophylaxis ID DEEP-VEIN THROMBOSIS; PLACEBO-CONTROLLED TRIAL; VENA-CAVA FILTERS; PULMONARY-EMBOLISM; POSTTHROMBOTIC SYNDROME; RISK-FACTORS; ILL PATIENTS; PROPHYLAXIS; METAANALYSIS; ENOXAPARIN AB Venous thromboembolism (VTE) is a clinical disease entity which is manifested as deep venous thrombosis and/or pulmonary embolism. VTE presenting as pulmonary embolism (PE) is one of the leading causes of mortality and morbidity in the United States. Pulmonary embolism accounts for 5-10% of deaths in hospitalized patients, making VTE the most common preventable cause of in-hospital death. It appears that PE is more common in hospitalized medical patients than surgical patients, although medical patients are less likely to receive VTE prophylaxis. Up to 15% of hospitalized medical patients who do not receive thromboprophylaxis will develop symptomatic VTE. Fatal PE also seems to occur more frequently in medical rather than surgical patients. The economic burden of VTE is substantial. In 2004, the cost of a VTE occurring in hospital added over $18,000 USD to the median cost of an individual hospitalization and increased the length of stay by a median of almost 10 days. The costs associated with long-term management and chronic complications of VTE that arise after discharge from hospital are also significant. VTE prophylaxis is underused or applied incorrectly in medically ill hospitalized patients. This trend is certain to improve as external regulatory forces monitor physician practices and clinical outcomes. This review summarizes the large body of data on VTE risk factors, the efficacy and safety of pharmacologic and mechanical prophylaxis, and consensus guideline recommendations for primary in-hospital prophylaxis of medical patients. C1 [Kessler, Craig M.] Georgetown Univ, Div Hematol Oncol, Lombardi Comprehens Canc Ctr, Med Ctr, Washington, DC USA. [Cap, Andrew P.] Walter Reed Army Med Ctr, Div Hematol Oncol, Washington, DC 20307 USA. RP Kessler, CM (reprint author), Georgetown Univ, Div Hematol Oncol, Lombardi Comprehens Canc Ctr, Med Ctr, Washington, DC USA. EM kesslerc@gunet.georgetown.edu FU PFIZER FX Editorial support was provided by Informal Healthcare and distribution was funded by PFIZER NR 54 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0735-7907 J9 CANCER INVEST JI Cancer Invest. PD MAR PY 2009 VL 27 BP 17 EP 27 DI 10.1080/07357900802656525 PG 11 WC Oncology SC Oncology GA 453DC UT WOS:000266589400003 ER PT J AU McGlynn, KA Quraishi, SM Graubard, BI Weber, JP Rubertone, MV Erickson, RL AF McGlynn, Katherine A. Quraishi, Sabah M. Graubard, Barry I. Weber, Jean-Philippe Rubertone, Mark V. Erickson, Ralph L. TI Polychlorinated Biphenyls and Risk of Testicular Germ Cell Tumors SO CANCER RESEARCH LA English DT Article ID MALE REPRODUCTIVE FUNCTION; ORGANOCHLORINE COMPOUNDS; EXPOSURE; P,P'-DDE; FERTILITY; CANCER; POPULATION; CONGENERS; TOXICITY; MARKERS AB Exposure to endocrine-disrupting chemicals, such as polychlorinated biphenyls (PCB), may alter hormonal balance and thereby increase risk of testicular germ cell tumors (TGCT). To study the relationship of PCBs to TGCT, prediagnostic serum samples from 736 cases and 913 controls in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Adjusted odds ratios and 95% confidence intervals were estimated using logistic regression. PCB levels were examined in association with all TGCT and, separately, with each histologic type (seminoma and nonseminoma). Risks associated with seven functional groupings of PCBs, as well as sum of PCBs, were also examined. There were significantly decreased risks of TGCT in association with eight PCBs (PCB-118, PCB-138, PCB-153, PCB-156, PCB-163, PCB-170, PCB-180, and PCB-187) and no association Pith the remaining three (PCB-99, PCB-101, and PCB-183). The same eight congeners were significantly associated with decreased risk of nonseminoma, whereas five (PCB-138, PCB-153, PCB-156, PCB-163, and PCB-170) were associated with decreased risk of seminoma. All functional groupings of PCBs were also associated with decreased risk of TGCT and of nonseminoma, whereas six of the seven functional groups were associated with decreased risk of seminoma. Sum of PCBs was significantly associated with decreased risk of TGCT (P(trend) = 0.006), nonseminoma (P(trend) = 0.007), and seminoma (P(trend) = 0.05). Overall, these data do not support the hypothesis that PCB exposure increases the risk of TGCT. [Cancer Res 2009;69(5):1901.-9] C1 [McGlynn, Katherine A.] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA. [Weber, Jean-Philippe] Inst Natl Sante Publ Quebec, Toxicol Ctr, Quebec City, PQ, Canada. [Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP McGlynn, KA (reprint author), NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, EPS Suite 550,6120 Execut Blvd, Rockville, MD 20852 USA. EM mcglynnk@mail.nih.gov FU National Cancer Institute; NIH Department of Health and Human Services FX The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting the views of the U.S. Department of the Army or the U.S. Department of Defense. NR 36 TC 27 Z9 28 U1 1 U2 7 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD MAR 1 PY 2009 VL 69 IS 5 BP 1901 EP 1909 DI 10.1158/0008-5472.CAN-08-3935 PG 9 WC Oncology SC Oncology GA 415ML UT WOS:000263937800029 PM 19223531 ER PT J AU Tang, ZJ Butkus, MA Xie, YFF AF Tang, Zhijian Butkus, Michael A. Xie, Yuefeng F. TI Enhanced performance of crumb rubber filtration for ballast water treatment SO CHEMOSPHERE LA English DT Article DE Ballast water; Crumb rubber; Filtration; Invasive species; Coagulation; Salinity ID GREAT-LAKES; TECHNOLOGY AB Waste-tire-derived crumb rubber was utilized as filter media to develop an efficient filter for ballast water treatment. In this study, the effects of coagulation, pressure filtration and dual-media (gravity) filtration on the performance of the crumb rubber filtration were investigated. The removal efficiencies of turbidity, phytoplankton and zooplankton, and head loss development were monitored during the filtration process. The addition of a coagulant enhanced the removal efficiencies of all targeted matter, but resulted in substantial increase of head loss. Pressure filtration increased filtration rates to 220 m(3) h(-1) m(-2) for 8-h operation and improved the zooplankton removal. Dual-media (crumb rubber/sand) gravity filtration also improved the removal efficiencies of phytoplankton and zooplankton over mono-media gravity crumb rubber filtration. However, these filtration techniques alone did not meet the criteria for removing indigenous organisms from ballast water. A combination of filtration and disinfection is suggested for future studies. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Xie, Yuefeng F.] Penn State Univ, Environm Engn Programs, Middletown, PA 17057 USA. [Butkus, Michael A.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. [Tang, Zhijian] Proc Engn Dept, Wilmington, MA 01887 USA. RP Xie, YFF (reprint author), Penn State Univ, Environm Engn Programs, Middletown, PA 17057 USA. EM yxx4@psu.edu FU United States National Oceanic and Atmospheric Administration (NOAA) [NA04OAR4170151] FX This study was supported by the United States National Oceanic and Atmospheric Administration (NOAA) under a Project NA04OAR4170151. During the study, Zhijian Tang was a postdoctoral scholar at the Pennsylvania State University. The field study was done with the assistance of William Rosevear, Manager of Gifford Pinchot State Park in Pennsylvania. NR 16 TC 25 Z9 26 U1 2 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2009 VL 74 IS 10 BP 1396 EP 1399 DI 10.1016/j.chemosphere.2008.11.048 PG 4 WC Environmental Sciences SC Environmental Sciences & Ecology GA 422MM UT WOS:000264432400018 PM 19117590 ER PT J AU Collen, J Lettieri, C Kelly, W Roop, S AF Collen, Jacob Lettieri, Christopher Kelly, William Roop, Stuart TI Clinical and Polysomnographic Predictors of Short-Term Continuous Positive Airway Pressure Compliance SO CHEST LA English DT Article DE compliance; continuous positive airways pressure; hypnotic; obstructive sleep apnea; polysomnography ID OBSTRUCTIVE SLEEP-APNEA; POPULATION-BASED SAMPLE; NASAL CPAP THERAPY; APNEA/HYPOPNEA SYNDROME; PATIENT COMPLIANCE; BLOOD-PRESSURE; ADHERENCE; ACCEPTANCE; HYPERTENSION; TITRATION AB Background: Poor compliance and initial intolerance limit the effectiveness of continuous positive airway pressure (CPAP) in obstructive sleep apnea. Short-term compliance has been shown to predict long-term use. Unfortunately, few identified variables reliably, predict initial CPAP tolerance and use. We sought to identify potential pretreatment variables that would predict short-term use of CPAP. Methods: We performed a retrospective review assessing short-term CPAP compliance after 4 to 6 weeks of treatment. Consecutive patients initiating CPAP therapy, were included. Demographic and polysomnographic variables were correlated with objective measures of CPAP use. The average hours per night and percentage of nights of CPAP use were correlated with each variable. Variables were also associated with good vs poor compliance, which we defined as > 4 It per night > 70% of nights. Results: We included 400 consecutive patients (78% male; mean age, 47 +/- 8 years). Of the measured variables, only age (48 +/- 8 years vs 46 +/- 7 years, p = 0.02) and use of a sedative/hypnotic during CPAP titration (77% vs 57.6%, p < 0.0005) were associated with better compliance. Those receiving a sedative/hypnotic had longer sleep times (345 +/- 42 min vs 314 +/- 51 min, p < 0.0005) and greater sleep efficiency (84 +/- 9% vs 78 +/- 11%, p < 0.0005) during polysonmography,. CPAP titrations were improved in those receiving sedative/hypnotics, achieving lower respiratory disturbance index on the final CPAP pressure (6 +/- 7 vs 10 +/- 11, p = 0.04). Conclusioms: Of the measured variables, only age and a one-time use of sedative/hypnotics during polysomnography, correlated with greater short-term CPAP compliance. Hypnotics facilitated better quality CPAP titrations. Reliable predictors of short-term CPAP use could help identify measures to improve long-term compliance. C1 [Collen, Jacob] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. [Lettieri, Christopher; Kelly, William; Roop, Stuart] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Collen, J (reprint author), 1375 Kenyon St NW,Apt 220, Washington, DC 20010 USA. EM jacob.collen@us.army.mil NR 51 TC 34 Z9 38 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD MAR PY 2009 VL 135 IS 3 BP 704 EP 709 DI 10.1378/chest.08-2182 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 420SW UT WOS:000264310500018 PM 19017888 ER PT J AU Ellsworth, RE Seebach, J Field, LA Heckman, C Kane, J Hooke, JA Love, B Shriver, CD AF Ellsworth, Rachel E. Seebach, Jeff Field, Lori A. Heckman, Caroline Kane, Jennifer Hooke, Jeffrey A. Love, Brad Shriver, Craig D. TI A gene expression signature that defines breast cancer metastases SO CLINICAL & EXPERIMENTAL METASTASIS LA English DT Article DE Breast cancer; Metastasis; Gene expression ID LYMPH-NODE METASTASES; PRIMARY TUMORS; CELLS; CARCINOMAS; INSIGHTS; DISTINCT; ORGAN AB The most important predictor of prognosis in breast cancer is lymph node status, yet little is known about molecular changes associated with lymph node metastasis. Here, gene expression analysis was performed on primary breast (PBT) and corresponding metastatic lymph node (MLN) tumors to identify molecular signatures associated with nodal metastasis. RNA was isolated after laser microdissection from frozen PBT and MLN from 20 patients with positive lymph nodes and hybridized to the microarray chips. Differential expression was determined using Mann-Whitney testing; Bonferroni corrected P values of 0.05 and 0.001 were calculated. Results were validated using TaqMan assays. Fifty-one genes were differentially expressed (P < 1 x 10(-5), less than twofold differences) between the PBT and paired MLN; 13 with significantly higher expression in the MLN and 38 in the PBT. qRT-PCR validated the differential expression of 40/51 genes. Of the 40 validated genes, NTS and PAX5 were found to have > 100-fold higher expression in MLT while COL11A1, KRT14, MMP13, TAC1 and WNT2 had > 100-fold higher expression in PBT. Gene expression differences between PBT and MLN suggests that expression of a unique set of genes is required for successful lymph node colonization. Genes expressed at higher levels in PBT are involved in degradation of the extracellular matrix, enabling cells with metastatic potential to disseminate, while genes expressed at higher levels in metastases are involved in transcription, signal transduction and immune response, providing cells with proliferation and survival advantages. These data improve our understanding of the biological processes involved in successful metastatis and provide new targets to arrest tumor cell dissemination and metastatic colonization. C1 [Ellsworth, Rachel E.] Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, Windber, PA 15963 USA. [Seebach, Jeff; Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. [Field, Lori A.; Heckman, Caroline; Kane, Jennifer] Windber Res Inst, Clin Breast Care Project, Windber, PA USA. [Love, Brad] Invitrogen, Carlsbad, CA USA. RP Ellsworth, RE (reprint author), Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM r.ellsworth@wriwindber.org NR 27 TC 49 Z9 50 U1 1 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0262-0898 J9 CLIN EXP METASTAS JI Clin. Exp. Metastasis PD MAR PY 2009 VL 26 IS 3 BP 205 EP 213 DI 10.1007/s10585-008-9232-9 PG 9 WC Oncology SC Oncology GA 413JD UT WOS:000263788500005 PM 19112599 ER PT J AU Edgerton, C Crispin, JC Moratz, CM Bettelli, E Oukka, M Simovic, M Zacharia, A Egan, R Chen, J Lucca, JJD Juang, YT Tsokos, GC AF Edgerton, Colin Crispin, Jose C. Moratz, Chantal M. Bettelli, Estelle Oukka, Mohamed Simovic, Milomir Zacharia, Athina Egan, Ryan Chen, Jie Lucca, Jurandir J. Dalle Juang, Yuang-Taung Tsokos, George C. TI IL-17 producing CD4(+) T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice SO CLINICAL IMMUNOLOGY LA English DT Article DE Autoimmunity; IL-17; IL-23; Inflammation; Ischemia reperfusion; MRL/lpr mice; p19(-/-) mice; Systemic lupus; erythematosus; T cell ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; INTERNATIONAL INCEPTION COHORT; DISEASE RISK-FACTORS; INFLAMMATORY RESPONSES; ISCHEMIA-REPERFUSION; DENDRITIC CELLS; TH17 CELLS; LPR MICE; ANTIBODIES; ENCEPHALOMYELITIS AB Elements of the innate and adaptive immune response have been implicated in the development of tissue damage after ischemic reperfusion (I/R). Here we demonstrate that T cells infiltrate the intestine of C57BL/6 mice subjected to intestinal I/R during the first hour of reperfusion. The intensity of the T cell infiltration was higher in B6.MRL/lpr mice subjected to intestinal I/R and reflected more severe tissue damage than that observed in control mice. Depletion of T cells limited I/R damage in B6.MRL/lpr mice, whereas repletion of B6.MRL/Ipr lymph node-derived T cells into the I/R-resistant Rag-1(-/-) mouse reconstituted tissue injury. The tissue-infiltrating T cells were found to produce IL-17. Finally, IL-23 deficient mice, which are known not to produce IL-17, displayed significantly less intestinal damage when subjected to I/R. Our data assign T cells a major rote in intestinal I/R damage by virtue of producing the proinflammatory cytokine IL-17. (C) 2008 Elsevier Inc. All rights reserved. C1 [Crispin, Jose C.; Chen, Jie; Juang, Yuang-Taung; Tsokos, George C.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA. [Edgerton, Colin; Moratz, Chantal M.; Simovic, Milomir; Zacharia, Athina] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Bettelli, Estelle; Oukka, Mohamed] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA. [Moratz, Chantal M.; Simovic, Milomir; Egan, Ryan; Lucca, Jurandir J. Dalle] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. RP Tsokos, GC (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, 330 Brookline Ave,CLS-937, Boston, MA 02115 USA. EM gtsokos@bidmc.harvard.edu FU National Institutes of Health [R01 A142269]; Medical Research Command [W81XWH-07-1-0286, W81XWH-06-1-0486] FX This work was supported by the National Institutes of Health Grant R01 A142269 and Medical Research Command grants W81XWH-07-1-0286 and W81XWH-06-1-0486. NR 40 TC 61 Z9 68 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD MAR PY 2009 VL 130 IS 3 BP 313 EP 321 DI 10.1016/j.clim.2008.09.019 PG 9 WC Immunology SC Immunology GA 409UD UT WOS:000263530400011 PM 19058762 ER PT J AU Hughes, SA Nadal, NC AF Hughes, S. A. Nadal, N. C. TI Laboratory study of combined wave overtopping and storm surge overflow of a levee SO COASTAL ENGINEERING LA English DT Article DE Wave overtopping; Negative freeboard; Overtopping discharge; Laboratory experiments; Combined wave and surge overtopping AB Combined wave overtopping and storm surge overflow of a levee with a trapezoidal cross section was studied in a two-dimensional laboratory wave/flow flume at a nominal prototype-to-model length scale of 25-to-1. The goal of this study was to develop design guidance in the aftermath of Hurricane Katrina. Time series of water depth at two locations on the levee crown and flow thickness at five locations on the landward-side slope were measured along with horizontal velocity near the landward edge of the crown. New equations are presented for average overtopping discharge, distribution of instantaneous discharge, and distribution of individual wave volumes. Equations are also given for mean flow thickness, RMS wave height, mean velocity, and velocity of the wave front down the landward-side slope. Published by Elsevier B.V. C1 [Hughes, S. A.; Nadal, N. C.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Hughes, SA (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Steven.A.Hughes@usace.army.mil FU Corps of Engineers New Orleans District FX The research described and the results presented herein, unless otherwise noted, were obtained from research funded by the Department of Homeland Security's Levee Strengthening and Damage Mitigation Program and by the Corps of Engineers New Orleans District. The laboratory experiments were conducted at the US Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory. Permission was granted by Headquarters, U.S. Army Corps of Engineers, to publish this information. Special thanks to Hugh Acuff, Julie Cohen, Tim Nisley, and David Daily for their careful and critical support of the laboratory experiments, and to Dr. Jeffrey Melby for a beneficial review of the early draft. The authors sincerely appreciate the thoughtful and constructive review comments of Dr. Holgar Schuttrumpf and the anonymous reviewers. Their suggestions added significantly to the final paper. NR 22 TC 30 Z9 30 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD MAR PY 2009 VL 56 IS 3 BP 244 EP 259 DI 10.1016/j.coastaleng.2008.09.005 PG 16 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 425RK UT WOS:000264654600004 ER PT J AU Kane, SF Cohen, MI AF Kane, Shawn F. Cohen, Michael I. TI Evaluation of the Asymptomatic Athlete With Hepatic and Urinalysis Abnormalities SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID AMERICAN-UROLOGICAL-ASSOCIATION; MICROSCOPIC HEMATURIA; PRACTICE POLICY; LIVER-DISEASE; PRIMARY-CARE; FOLLOW-UP; ADULTS; BACTERIURIA; CHILDREN; PATIENT AB KANE, S. F. and M. I. COHEN. Evaluation of the asymptomatic athlete with hepatic and urinalysis abnormalities. Curr. Sports Med. Rep., Vol. 8, No. 2, pp. 77-84, 2009. In general, there is no reason to evaluate either liver function tests or a urinalysis in asymptomatic athletes. However, at times they are ordered inadvertently, and when abnormal, the provider faces a quandary V ignore or evaluate them. Up to 20% of the liver function tests and urinalyses can be abnormal in the asymptomatic healthy athlete. The key concept for the provider is to quickly, accurately, and economically identify results that are normal variants from those that may be a prelude to a pathologic process. This article will discuss the most common etiologies of these abnormal laboratory tests as well as provide a framework to the follow-up evaluation. Our goal is to aid clinicians in keeping their athletes participating in their sports while at the same time not missing any significant illnesses. C1 [Kane, Shawn F.; Cohen, Michael I.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. RP Kane, SF (reprint author), Womack Army Med Ctr, Ft Bragg, NC 28310 USA. EM shawn.kane@us.army.mil NR 28 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAR-APR PY 2009 VL 8 IS 2 BP 77 EP 84 DI 10.1249/JSR.0b013e31819e0b8d PG 8 WC Sport Sciences SC Sport Sciences GA 570HU UT WOS:000275664700011 PM 19276908 ER PT J AU Ellis, M Xia, Y Creel, NB AF Ellis, Melissa Xia, Yang Creel, Naomi B. TI What Is Your Diagnosis? The Diagnosis: Lichen Striatus SO CUTIS LA English DT Editorial Material C1 [Ellis, Melissa] Virginia Coll Osteopath Med, Blacksburg, VA 24061 USA. [Xia, Yang] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. [Creel, Naomi B.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Ellis, M (reprint author), Virginia Coll Osteopath Med, Blacksburg, VA 24061 USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD MAR PY 2009 VL 83 IS 3 BP 118 EP + PG 3 WC Dermatology SC Dermatology GA 424CZ UT WOS:000264544400002 PM 19363902 ER PT J AU Franklin, SB Kupfer, JA Pezeshki, R Gentry, R Smith, RD AF Franklin, Scott B. Kupfer, John A. Pezeshki, Reza Gentry, Randy Smith, R. Daniel TI Efficacy of the hydrogeomorphic model (HGM): A case study from western Tennessee SO ECOLOGICAL INDICATORS LA English DT Article DE Floodplain forest; Hydrogeomorphic model; Validation; Channelization; Functional assessment; Levee ID FLOODPLAIN FORESTS; RIVER-FLOODPLAIN; COASTAL-PLAIN; STREAM CHANNELIZATION; FUNCTIONAL ASSESSMENT; VEGETATION PATTERNS; FLUVIAL LANDFORMS; NEW-JERSEY; RESTORATION; HYDROLOGY AB Hydrogeomorphic models (HGM) for wetland classification and functional assessment have been developed for several regions in the United States. However, validation of models is lacking, even though models are already in use and the general idea is that each is a working model, developing over time with new ideas and information. We examined the HGM developed for western Tennessee using novel data collected from six stream systems, two channelized, two channelized and leveed, and two unchannelized. The western Tennessee HGM has the ability to differentiate altered and unaltered rivers based mainly on changes to hydrologic floodplain functions, although functional capacity index values were validated from independent measures. Effects of channelization were confounded in western Tennessee by other disturbances, channel recovery processes, and variability due to levee construction. Levees render the greatest change to floodplains as they disconnect the channel and floodplain system, decreasing water tables and possible exchanges. One of the main factors controlling productivity along channels without levees was sedimentation. We recommend that estimated rates of sedimentation be incorporated into an updated version of the HGM. Variability of human alterations and natural floodplain heterogeneity suggest landscape factors (e.g., beta diversity, degree of ponding) and use of gradient indices may result in greater resolution for determining functional capacity of low gradient, riverine systems. Published by Elsevier Ltd. C1 [Franklin, Scott B.; Pezeshki, Reza] Univ Memphis, Dept Biol, Memphis, TN 38152 USA. [Kupfer, John A.] Univ S Carolina, Dept Geog, Columbia, SC 29208 USA. [Gentry, Randy] Univ Tennessee, SE Water Resources Inst, Knoxville, TN USA. [Smith, R. Daniel] USA, Corps Engineers, Waterways Expt Stn, Vicksburg, MS 39180 USA. [Franklin, Scott B.; Kupfer, John A.] Edward J Meeman Biol Field Stn, Millington, TN USA. RP Franklin, SB (reprint author), Univ Memphis, Dept Biol, Memphis, TN 38152 USA. EM sfrankli@memphis.edu RI Kupfer, John/H-4066-2011; Gentry, Randall/J-8177-2012 OI Gentry, Randall/0000-0003-2477-8127 FU Tennessee Department of Environment and Conservation; U.S. Army Corps of Engineers; Meeman Field Station FX This research was supported in part by contracts with the Tennessee Department of Environment and Conservation and the U.S. Army Corps of Engineers. We wish to thank the many people who assisted in data collection and analysis, especially Natasja van Gestel, Stacy Anderson, Karla Gage, Kit Brown, Melissa Lee, Mitch Elcan and Jason Farmer, as well as Ellen Williams (TDEC) for her help. Facilities provided by the Edward J. Meeman Biological Field Station were essential for this project, and completion of the final manuscript was facilitated by a Summer Visiting Scholar grant from the Meeman Field Station to JAK. NR 88 TC 8 Z9 8 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X J9 ECOL INDIC JI Ecol. Indic. PD MAR PY 2009 VL 9 IS 2 BP 267 EP 283 DI 10.1016/j.ecolind.2008.05.004 PG 17 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 378CI UT WOS:000261298300006 ER PT J AU Farr, JV Brazil, DM AF Farr, John V. Brazil, Donna M. TI Leadership Skills Development for Engineers SO EMJ-ENGINEERING MANAGEMENT JOURNAL LA English DT Article DE Leadership Education; Leadership; Lifelong Learning; Leadership Development; Self Actualization AB Leadership must be a key element advancing for the engineering profession to remain relevant and connected in an era of heightened outsourcing and global competition. Companies intent on maintaining a competitive edge are Calling upon educators to produce engineers capable of leading multidisciplinary teams, combine technical ingenuity with business acumen, and produce graduates who have a passion for lifelong learning. Industry is also challenging universities to broaden curricula beyond the intellectual endeavors of design and scientific inquiry to the greater domain of professional leadership and entrepreneurship. Managers in industry are similarly challenged to cultivate key leadership attributes in junior engineers. I his article explores the changing nature of engineering in a globally competitive environment and addresses why leadership must become a key issue in the career progression of engineers. We will present a literature review of leadership models along with some proposed Solutions for cultivating leadership skills as part of the career development process. Lastly, we will present specific recommendations on how to cultivate leadership attributes throughout an engineering career. C1 [Farr, John V.] Stevens Inst Technol, Sch Syst & Enterprises, Dept Syst Engn & Engn Management, Hoboken, NJ 07030 USA. [Farr, John V.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Farr, JV (reprint author), Stevens Inst Technol, Sch Syst & Enterprises, Dept Syst Engn & Engn Management, Hoboken, NJ 07030 USA. EM jfarr@stevens.edu NR 18 TC 22 Z9 22 U1 3 U2 19 PU AMER SOC ENGINEERING MANAGEMENT PI ROLLA PA PO BOX 820, ROLLA, MO 65402 USA SN 1042-9247 J9 EMJ-ENG MANAG J JI EMJ-Eng. Manag. J. PD MAR PY 2009 VL 21 IS 1 BP 3 EP 8 PG 6 WC Engineering, Industrial; Management SC Engineering; Business & Economics GA 424ZP UT WOS:000264607100002 ER PT J AU Bannon, DI Johnson, M Williams, L Adams, V Perkins, E Gust, K Gong, P AF Bannon, Desmond I. Johnson, Mark Williams, Larry Adams, Valerie Perkins, Edward Gust, Kurt Gong, Ping TI RDX and miRNA Expression in B6C3F1 Mice SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Letter ID MICRORNAS; LIVER C1 [Bannon, Desmond I.; Johnson, Mark; Williams, Larry; Adams, Valerie] USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, Aberdeen Proving Ground, MD USA. [Perkins, Edward; Gust, Kurt; Gong, Ping] USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS USA. RP Bannon, DI (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, Aberdeen Proving Ground, MD USA. EM desmond.bannon@us.army.mil NR 6 TC 2 Z9 2 U1 0 U2 0 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAR PY 2009 VL 117 IS 3 BP A98 EP A98 DI 10.1289/ehp.0800276 PG 1 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 415KV UT WOS:000263933600002 PM 19337499 ER PT J AU Raney, NH Petersen, EJ Smith, TA Cowan, JE Rendeiro, DG Deyle, GD Childs, JD AF Raney, Nicole H. Petersen, Evan J. Smith, Tracy A. Cowan, James E. Rendeiro, Daniel G. Deyle, Gail D. Childs, John D. TI Development of a clinical prediction rule to identify patients with neck pain likely to benefit from cervical traction and exercise SO EUROPEAN SPINE JOURNAL LA English DT Article DE Neck pain; Classification; Cervical traction ID LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; FEAR-AVOIDANCE BELIEFS; PHYSICAL-THERAPY; NONOPERATIVE MANAGEMENT; GENERAL-PRACTITIONER; MANIPULATIVE THERAPY; SPINAL MANIPULATION; OUTCOME MEASURES; DIAGNOSTIC-TEST AB The objective of the study was to develop a clinical prediction rule (CPR) to identify patients with neck pain likely to improve with cervical traction. The study design included prospective cohort of patients with neck pain referred to physical therapy. Development of a CPR will assist clinicians in classifying patients with neck pain likely to benefit from cervical traction. Eighty patients with neck pain received a standardized examination and then completed six sessions of intermittent cervical traction and cervical strengthening exercises twice weekly for 3 weeks. Patient outcome was classified at the end of treatment, based on perceived recovery according to the global rating of change. Patients who achieved a change a parts per thousand yen+6 ("A great deal better" or "A very great deal better") were classified as having a successful outcome. Univariate analyses (t tests and chi-square) were conducted on historical and physical examination items to determine potential predictors of successful outcome. Variables with a significance level of P a parts per thousand currency sign 0.15 were retained as potential prediction variables. Sensitivity, specificity and positive and negative likelihood ratios (LRs) were then calculated for all variables with a significant relationship with the reference criterion of successful outcome. Potential predictor variables were entered into a step-wise logistic regression model to determine the most accurate set of clinical examination items for prediction of treatment success. Sixty-eight patients (38 female) were included in data analysis of which 30 had a successful outcome. A CPR with five variables was identified: (1) patient reported peripheralization with lower cervical spine (C4-7) mobility testing; (2) positive shoulder abduction test; (3) age a parts per thousand yen55; (4) positive upper limb tension test A; and (5) positive neck distraction test. Having at least three out of five predictors present resulted in a +LR equal to 4.81 (95% CI = 2.17-11.4), increasing the likelihood of success with cervical traction from 44 to 79.2%. If at least four out of five variables were present, the +LR was equal to 23.1 (2.5-227.9), increasing the post-test probability of having improvement with cervical traction to 94.8%. This preliminary CPR provides the ability to a priori identify patients with neck pain likely to experience a dramatic response with cervical traction and exercise. Before the rule can be implemented in routine clinical practice, future studies are necessary to validate the rule. The CPR developed in this study may improve clinical decision-making by assisting clinicians in identifying patients with neck pain likely to benefit from cervical traction and exercise. C1 [Raney, Nicole H.] Wilford Hall USAF Med Ctr, Dept Phys Therapy, San Antonio, TX 78209 USA. [Petersen, Evan J.] Brooke Army Med Ctr, Dept Phys Therapy, San Antonio, TX USA. [Smith, Tracy A.] US Sergeants Major Acad, Army Phys Fitness Res Inst, El Paso, TX USA. [Cowan, James E.] USN, Special Warfare Ctr, BUD S, Coronado, CA USA. [Rendeiro, Daniel G.] Carl R Darnall Army Med Ctr, Phys Therapy Serv, Ft Hood, TX USA. [Deyle, Gail D.] USA, Brooke Army Med Ctr, Ft Sam Houston, TX USA. [Childs, John D.] Baylor Univ, USA, Ft Sam Houston, TX USA. RP Raney, NH (reprint author), Wilford Hall USAF Med Ctr, Dept Phys Therapy, 134 Evans Ave, San Antonio, TX 78209 USA. EM Sanantoniogirl1@hotmail.com; evan.petersen@amedd.army.mil; tracy.alexandra.smith@gmail.com; James.cowan@navsoc.socom.mil; Daniel.rendeiro@amedd.army.mil; gdeyle@satx.rr.com; childsjd@gmail.com FU Brooke Army Medical Center; Department of the Army; Department of the Air Force; Department of the Navy; Department of Defense FX This study was approved by the Institutional Review Board at Brooke Army Medical Center, Fort Sam Houston, Texas. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official as reflecting the views of the Department of the Army, Department of the Air Force, Department of the Navy, or the Department of Defense. NR 64 TC 25 Z9 27 U1 1 U2 21 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0940-6719 EI 1432-0932 J9 EUR SPINE J JI Eur. Spine J. PD MAR PY 2009 VL 18 IS 3 BP 382 EP 391 DI 10.1007/s00586-008-0859-7 PG 10 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 414NE UT WOS:000263870200013 PM 19142674 ER PT J AU Amelino-Camelia, G Aplin, K Arndt, M Barrow, JD Bingham, RJ Borde, C Bouyer, P Caldwell, M Cruise, AM Damour, T D'Arrigo, P Dittus, H Ertmer, W Foulon, B Gill, P Hammond, GD Hough, J Jentsch, C Johann, U Jetzer, P Klein, H Lambrecht, A Lamine, B Lammerzahl, C Lockerbie, N Loeffler, F Mendonca, JT Mester, J Ni, WT Pegrum, C Peters, A Rasel, E Reynaud, S Shaul, D Sumner, TJ Theil, S Torrie, C Touboul, P Trenkel, C Vitale, S Vodel, W Wang, C Ward, H Woodgate, A AF Amelino-Camelia, G. Aplin, K. Arndt, M. Barrow, J. D. Bingham, R. J. Borde, C. Bouyer, P. Caldwell, M. Cruise, A. M. Damour, T. D'Arrigo, P. Dittus, H. Ertmer, W. Foulon, B. Gill, P. Hammond, G. D. Hough, J. Jentsch, C. Johann, U. Jetzer, P. Klein, H. Lambrecht, A. Lamine, B. Laemmerzahl, C. Lockerbie, N. Loeffler, F. Mendonca, J. T. Mester, J. Ni, W. -T. Pegrum, C. Peters, A. Rasel, E. Reynaud, S. Shaul, D. Sumner, T. J. Theil, S. Torrie, C. Touboul, P. Trenkel, C. Vitale, S. Vodel, W. Wang, C. Ward, H. Woodgate, A. TI GAUGE: the GrAnd Unification and Gravity Explorer SO EXPERIMENTAL ASTRONOMY LA English DT Article DE Fundamental physics; Space mission; Equivalence principle; Mass-spin coupling; Atom interferometry ID NONCONFORMAL METRIC FLUCTUATIONS; QUANTUM-GRAVITY; EQUIVALENCE PRINCIPLE; SYMMETRY-BREAKING; BROWNIAN-MOTION; DECOHERENCE; SPACETIME; AXION; REDUCTION; PARTICLES AB The GAUGE (GrAnd Unification and Gravity Explorer) mission proposes to use a drag-free spacecraft platform onto which a number of experiments are attached. They are designed to address a number of key issues at the interface between gravity and unification with the other forces of nature. The equivalence principle is to be probed with both a high-precision test using classical macroscopic test bodies, and, to lower precision, using microscopic test bodies via cold-atom interferometry. These two equivalence principle tests will explore string-dilaton theories and the effect of space-time fluctuations respectively. The macroscopic test bodies will also be used for intermediate-range inverse-square law and an axion-like spin-coupling search. The microscopic test bodies offer the prospect of extending the range of tests to also include short-range inverse-square law and spin-coupling measurements as well as looking for evidence of quantum decoherence due to space-time fluctuations at the Planck scale. C1 Univ Roma Sapienza, Dipartmento Fis, Rome, Italy. Sci & Technol Facil Council, Rutherford Appleton Lab, Didcot, Oxon, England. Univ Wien, Inst Experimentalphysik, Vienna, Austria. Syst Reference Temps Espace Lab Phys Lasers, Paris, France. Inst dOpt, Laboratoire Charles Fabry, Palaiseau, France. Inst Hautes Etud Scientif, Bures-sur-Yvette, France. EADS Astrium, Stevenage, Herts, England. Univ Bremen, ZARM, Bremen, Germany. Leibniz Univ Hannover, Inst Quantum Optic, Hannover, NH, Germany. Off Natl Etud & Rech Aerosp, Chatillon, France. Natl Phys Lab, Teddington, Middx, England. Univ Glasgow, Inst Gravitat Res, Glasgow, Lanark, Scotland. EADS Astrium, Friedrichshafen, Germany. Univ Zurich, Inst Theoret Phys, Zurich, Switzerland. Laboratoire Kastler Brossel, Paris, France. Univ Strathclyde, Glasgow, Lanark, Scotland. Physikalisch Techn Bundesanstalt, Braunschweig, Germany. Inst Super T, Cnico, Lisbon, Portugal. Stanford Univ, Standford, USA, Stanford, CA USA. Humboldt Univ, Berlin, Germany. Univ Trento, Trento, Italy. Friedrich Schiller Univ, Jena, Germany. [Shaul, D.; Sumner, T. J.] Univ London Imperial Coll Sci Technol & Med, London, England. [Peters, A.] Humboldt Univ, Berlin, Germany. [Ni, W. -T.] Acad Sinica, Purple Mt Observ, Nanjing 210008, Peoples R China. [Mester, J.] Stanford Univ, Stanford, CA 94305 USA. [Mendonca, J. T.] Inst Super Tecn, Lisbon, Portugal. [Vitale, S.] Univ Trento, Trento, Italy. [Vodel, W.] Univ Jena, Jena, Germany. [Wang, C.] Univ Aberdeen, Aberdeen, Scotland. [Amelino-Camelia, G.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy. [Aplin, K.; Bingham, R. J.; Caldwell, M.] Rutherford Appleton Lab, Sci & Technol Facil Council, Didcot OX11 0QX, Oxon, England. [Arndt, M.] Univ Vienna, Inst Expt Phys, A-1090 Vienna, Austria. [Barrow, J. D.] Univ Cambridge, Dept Appl Math & Theoret Phys, Cambridge CB3 9EW, England. [Borde, C.] Syst Reference Temps Espace Lab Phys Lasers, Paris, France. [Bouyer, P.] Inst Opt, Lab Charles Fabry, Palaiseau, France. [Cruise, A. M.; Hammond, G. D.] Univ Birmingham, Birmingham, W Midlands, England. [Damour, T.] Inst Hautes Etud Sci, F-91440 Bures Sur Yvette, France. [D'Arrigo, P.; Trenkel, C.] EADS Astrium, Stevenage, Herts, England. [Dittus, H.; Laemmerzahl, C.; Theil, S.] Univ Bremen, ZARM, Bremen, Germany. [Ertmer, W.; Rasel, E.] Leibniz Univ Hannover, Inst Quantum Opt, Hannover, Germany. [Foulon, B.; Touboul, P.] Off Natl Etud & Rech Aerosp, Chatillon, France. [Gill, P.; Klein, H.] Natl Phys Lab, Teddington TW11 0LW, Middx, England. [Hough, J.; Torrie, C.; Ward, H.; Woodgate, A.] Univ Glasgow, Inst Gravitat Res, Glasgow, Lanark, Scotland. [Jentsch, C.; Johann, U.] EADS, Friedrichshafen, Germany. [Jetzer, P.] Univ Zurich, Inst Theoret Phys, CH-8001 Zurich, Switzerland. [Lambrecht, A.; Lamine, B.; Reynaud, S.] Lab Kastler Brossel, Paris, France. [Lockerbie, N.; Pegrum, C.] Univ Strathclyde, Glasgow, Lanark, Scotland. [Loeffler, F.] Phys Tech Bundesanstalt, D-3300 Braunschweig, Germany. RP Sumner, TJ (reprint author), Univ London Imperial Coll Sci Technol & Med, London, England. EM t.sumner@imperial.ac.uk RI Theil, Stephan/O-2305-2015; Laemmerzahl, Claus/P-3552-2016; Peters, Achim/G-3742-2010; Hammond, Giles/B-7861-2009; BOUYER, Philippe/A-9823-2009; Hammond, Giles/A-8168-2012; Lamine, Brahim/J-8907-2012; Reynaud, Serge/J-8061-2014; Lambrecht, Astrid/K-1208-2014; Vitale, Stefano/C-2312-2012; Arndt, Markus/A-4571-2012 OI Theil, Stephan/0000-0002-5346-8091; Laemmerzahl, Claus/0000-0002-8276-5415; Mendonca, Jose Tito/0000-0001-8951-3395; BOUYER, Philippe/0000-0003-4458-0089; Lamine, Brahim/0000-0002-9416-2320; Reynaud, Serge/0000-0002-1494-696X; Lambrecht, Astrid/0000-0002-5193-1222; Vitale, Stefano/0000-0002-2427-8918; Arndt, Markus/0000-0002-9487-4985 NR 56 TC 8 Z9 8 U1 0 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0922-6435 EI 1572-9508 J9 EXP ASTRON JI Exp. Astron. PD MAR PY 2009 VL 23 IS 2 BP 549 EP 572 DI 10.1007/s10686-008-9086-9 PG 24 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 409KW UT WOS:000263505600003 ER PT J AU Kuppers, M Keller, HU Kuhrt, E A'Hearn, MF Altwegg, K Bertrand, R Busemann, H Capria, MT Colangeli, L Davidsson, B Ehrenfreund, P Knollenberg, J Mottola, S Rathke, A Weiss, P Zolensky, M Akim, E Basilevsky, A Galimov, E Gerasimov, M Korablev, O Lomakin, I Marov, M Martynov, M Nazarov, M Zakharov, A Zelenyi, L Aronica, A Ball, AJ Barbieri, C Bar-Nun, A Benkhoff, J Biele, J Biver, N Blum, J Bockelee-Morvan, D Botta, O Bredehoft, JH Capaccioni, F Charnley, S Cloutis, E Cottin, H Cremonese, G Crovisier, J Crowther, SA Epifani, EM Esposito, F Ferrari, AC Ferri, F Fulle, M Gilmour, J Goesmann, F Gortsas, N Green, SF Groussin, O Grun, E Gutierrez, PJ Hartogh, P Henkel, T Hilchenbach, M Ho, TM Horneck, G Hviid, SF Ip, WH Jackel, A Jessberger, E Kallenbach, R Kargl, G Komle, NI Korth, A Kossacki, K Krause, C Kruger, H Li, ZY Licandro, J Lopez-Moreno, JJ Lowry, SC Lyon, I Magni, G Mall, U Mann, I Markiewicz, W Martins, Z Maurette, M Meierhenrich, U Mennella, V Ng, TC Nittler, LR Palumbo, P Patzold, M Prialnik, D Rengel, M Rickman, H Rodriguez, J Roll, R Rost, D Rotundi, A Sandford, S Schonbachler, M Sierks, H Srama, R Stroud, RM Szutowicz, S Tornow, C Ulamec, S Wallis, M Waniak, W Weissman, P Wieler, R Wurz, P Yung, KL Zarnecki, JC AF Kueppers, Michael Keller, H. U. Kuehrt, E. A'Hearn, M. F. Altwegg, K. Bertrand, R. Busemann, H. Capria, M. T. Colangeli, L. Davidsson, B. Ehrenfreund, P. Knollenberg, J. Mottola, S. Rathke, A. Weiss, P. Zolensky, M. Akim, E. Basilevsky, A. Galimov, E. Gerasimov, M. Korablev, O. Lomakin, I. Marov, M. Martynov, M. Nazarov, M. Zakharov, A. Zelenyi, L. Aronica, A. Ball, A. J. Barbieri, C. Bar-Nun, A. Benkhoff, J. Biele, J. Biver, N. Blum, J. Bockelee-Morvan, D. Botta, O. Bredehoeft, J. -H. Capaccioni, F. Charnley, S. Cloutis, E. Cottin, H. Cremonese, G. Crovisier, J. Crowther, S. A. Epifani, E. M. Esposito, F. Ferrari, A. C. Ferri, F. Fulle, M. Gilmour, J. Goesmann, F. Gortsas, N. Green, S. F. Groussin, O. Gruen, E. Gutierrez, P. J. Hartogh, P. Henkel, T. Hilchenbach, M. Ho, T. -M. Horneck, G. Hviid, S. F. Ip, W. -H. Jaeckel, A. Jessberger, E. Kallenbach, R. Kargl, G. Koemle, N. I. Korth, A. Kossacki, K. Krause, C. Krueger, H. Li, Z. -Y. Licandro, J. Lopez-Moreno, J. J. Lowry, S. C. Lyon, I. Magni, G. Mall, U. Mann, I. Markiewicz, W. Martins, Z. Maurette, M. Meierhenrich, U. Mennella, V. Ng, T. C. Nittler, L. R. Palumbo, P. Paetzold, M. Prialnik, D. Rengel, M. Rickman, H. Rodriguez, J. Roll, R. Rost, D. Rotundi, A. Sandford, S. Schoenbaechler, M. Sierks, H. Srama, R. Stroud, R. M. Szutowicz, S. Tornow, C. Ulamec, S. Wallis, M. Waniak, W. Weissman, P. Wieler, R. Wurz, P. Yung, K. L. Zarnecki, J. C. TI Triple F-a comet nucleus sample return mission SO EXPERIMENTAL ASTRONOMY LA English DT Article DE Comets; Cosmogony; Sample return; Space mission ID DEEP IMPACT OBSERVATIONS; TERRESTRIAL PLANETS; MECHANICAL-PROPERTIES; ROSETTA MISSION; ORGANIC-MATTER; SOLAR-SYSTEM; WATER ICE; ORIGIN; SURFACE; SPECTROMETER AB The Triple F (Fresh From the Fridge) mission, a Comet Nucleus Sample Return, has been proposed to ESA's Cosmic Vision program. A sample return from a comet enables us to reach the ultimate goal of cometary research. Since comets are the least processed bodies in the solar system, the proposal goes far beyond cometary science topics (like the explanation of cometary activity) and delivers invaluable information about the formation of the solar system and the interstellar molecular cloud from which it formed. The proposed mission would extract three sample cores of the upper 50 cm from three locations on a cometary nucleus and return them cooled to Earth for analysis in the laboratory. The simple mission concept with a touch-and-go sampling by a single spacecraft was proposed as an M-class mission in collaboration with the Russian space agency ROSCOSMOS. C1 [Kueppers, Michael; Keller, H. U.; Goesmann, F.; Hartogh, P.; Hilchenbach, M.; Hviid, S. F.; Kallenbach, R.; Korth, A.; Krueger, H.; Mall, U.; Markiewicz, W.; Rengel, M.; Roll, R.; Sierks, H.] Max Planck Inst Solar Syst Res, D-37191 Katlenburg Lindau, Germany. [Kueppers, Michael; Lyon, I.] European Space Astron Ctr, Madrid 28691, Spain. [Kuehrt, E.; Knollenberg, J.; Mottola, S.; Benkhoff, J.; Biele, J.; Horneck, G.; Krause, C.; Tornow, C.] DLR, Berlin, Germany. [A'Hearn, M. F.] Univ Maryland, College Pk, MD 20742 USA. [Altwegg, K.; Jaeckel, A.; Wurz, P.] Univ Bern, Bern, Switzerland. [Bertrand, R.] CNES, Toulouse, France. [Busemann, H.; Ball, A. J.; Green, S. F.; Zarnecki, J. C.] Open Univ, Milton Keynes MK7 6AA, Bucks, England. [Capria, M. T.; Capaccioni, F.; Magni, G.] IASF INAF, Rome, Italy. [Colangeli, L.; Epifani, E. M.; Esposito, F.; Mennella, V.] Osserv Astron Capodimonte, INAF, I-80131 Naples, Italy. [Davidsson, B.; Rickman, H.] Uppsala Univ, Uppsala, Sweden. [Ehrenfreund, P.] Leiden Univ, Leiden, Netherlands. [Rathke, A.] EADS Astrium, Friedrichshafen, Germany. [Weiss, P.; Ng, T. C.; Yung, K. L.] Hong Kong Polytech Univ, Hong Kong, Hong Kong, Peoples R China. [Zolensky, M.] NASA, Lyndon B Johnson Space Ctr, Houston, TX 77058 USA. [Akim, E.; Marov, M.] Keldysh Inst, Moscow, Russia. [Basilevsky, A.; Galimov, E.; Nazarov, M.] Vernadskij Inst, Moscow, Russia. [Gerasimov, M.; Korablev, O.; Zakharov, A.; Zelenyi, L.] Space Res Inst, Moscow, Russia. [Lomakin, I.; Martynov, M.] Lavochkin Assoc, Moscow, Russia. [Aronica, A.; Palumbo, P.; Rotundi, A.] Univ Naples Federico 2, Naples, Italy. [Barbieri, C.; Cremonese, G.; Ferri, F.] Univ Padua, Padua, Italy. [Bar-Nun, A.; Prialnik, D.] Tel Aviv Univ, IL-69978 Tel Aviv, Israel. [Blum, J.] Tech Univ Carolo Wilhelmina Braunschweig, Braunschweig, Germany. [Botta, O.] Int Space Sci Inst, Bern, Switzerland. [Bredehoeft, J. -H.] Univ Bremen, Bremen, Germany. [Cloutis, E.] Univ Winnipeg, Winnipeg, MB R3B 2E9, Canada. [Cottin, H.] Univ Paris, F-75252 Paris, France. [Gruen, E.; Srama, R.] MPIfK, Heidelberg, Germany. [Gutierrez, P. J.; Lopez-Moreno, J. J.; Rodriguez, J.] CSIC, IAA, Granada, Spain. [Ho, T. -M.] ESA, Estec, Noordwijk, Netherlands. [Ip, W. -H.; Li, Z. -Y.] Natl Cent Univ, Taipei, Taiwan. [Jessberger, E.] Univ Munster, Munster, Germany. [Kargl, G.; Koemle, N. I.] IWF, Graz, Austria. [Kossacki, K.] Univ Warsaw, Warsaw, Poland. [Licandro, J.] IAC, Tenerife, Spain. [Lowry, S. C.] Queens Univ Belfast, Belfast, Antrim, North Ireland. [Mann, I.] Kobe Univ, Kobe, Hyogo 657, Japan. [Maurette, M.] CNRS, F-91405 Orsay, France. [Meierhenrich, U.] Univ Nice, Nice, France. [Nittler, L. R.] Carnegie Inst Washington, Washington, DC 20005 USA. [Paetzold, M.] Univ Cologne, Cologne, Germany. [Sandford, S.] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. [Stroud, R. M.] USA, Res Lab, Washington, DC 20310 USA. [Szutowicz, S.] PAS, Space Res Ctr, Warsaw, Poland. [Ulamec, S.] DLR, Cologne, Germany. [Wallis, M.] Cardiff Univ, Cardiff, Wales. [Waniak, W.] Krakow Tech Univ, PL-31155 Krakow, Poland. [Weissman, P.] JPL, Pasadena, CA USA. [Wieler, R.] ETH, Zurich, Switzerland. [Martins, Z.; Schoenbaechler, M.] Univ London Imperial Coll Sci Technol & Med, London, England. [Groussin, O.] LAM, Marseille, France. [Fulle, M.] Trieste Observ, Trieste, Italy. [Ferrari, A. C.] Univ Cambridge, Cambridge, England. [Crowther, S. A.; Gilmour, J.; Henkel, T.; Lyon, I.; Rost, D.] Univ Manchester, Manchester, Lancs, England. [Charnley, S.] NASA, Ames Res Ctr, Mountain View, CA USA. [Biver, N.; Bockelee-Morvan, D.; Crovisier, J.] Observ Paris, Meudon, France. RP Kuppers, M (reprint author), Max Planck Inst Solar Syst Res, Max Planck Str 2, D-37191 Katlenburg Lindau, Germany. EM Michael.Kueppers@sciops.esa.int RI Stroud, Rhonda/C-5503-2008; Green, Simon/C-7408-2009; Wieler, Rainer/A-1355-2010; Blum, Jurgen/B-5590-2011; Gilmour, Jamie/G-7515-2011; Bredehoft, Jan Hendrik/E-4221-2012; Cottin, Herve/H-5654-2013; Korablev, Oleg/L-5083-2013; Meierhenrich, Uwe/A-1643-2008; Ball, Andrew/B-6747-2009; Gutierrez, Pedro/K-9637-2014; Crowther, Sarah/P-7082-2014; Lopez-Moreno, Jose Juan/C-7976-2011; Martins, Zita/H-4860-2015; OI Stroud, Rhonda/0000-0001-5242-8015; Busemann, Henner/0000-0002-0867-6908; Aronica, Alessandro/0000-0003-3205-9472; Cremonese, Gabriele/0000-0001-9021-1140; Esposito, Francesca/0000-0001-9962-1648; Crowther, Sarah/0000-0002-5396-1775; Lopez-Moreno, Jose Juan/0000-0002-7946-2624; Gilmour, Jamie/0000-0003-1990-8636; Capaccioni, Fabrizio/0000-0003-1631-4314; Wieler, Rainer/0000-0001-5666-7494; Blum, Jurgen/0000-0003-1531-737X; Bredehoft, Jan Hendrik/0000-0002-7977-6762; Cottin, Herve/0000-0001-9170-5265; Meierhenrich, Uwe/0000-0001-6422-3930; Ball, Andrew/0000-0003-1593-3279; Gutierrez, Pedro/0000-0002-7332-6269; Martins, Zita/0000-0002-5420-1081; fulle, marco/0000-0001-8435-5287; Rotundi, Alessandra/0000-0001-5467-157X; Korablev, Oleg/0000-0003-1115-0656 NR 63 TC 5 Z9 5 U1 1 U2 11 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0922-6435 J9 EXP ASTRON JI Exp. Astron. PD MAR PY 2009 VL 23 IS 3 BP 809 EP 847 DI 10.1007/s10686-008-9115-8 PG 39 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 409RP UT WOS:000263523800005 ER PT J AU Tournier, JN Ulrich, RG Quesnel-Hellmann, A Mohamadzadeh, M Stiles, BG AF Tournier, Jean-Nicolas Ulrich, Robert G. Quesnel-Hellmann, Anne Mohamadzadeh, Mansour Stiles, Bradley G. TI Anthrax, toxins and vaccines: a 125-year journey targeting Bacillus anthracis SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY LA English DT Review DE anthrax; Bacillus anthracis; PA; pathogenesis; protective antigen; vaccine ID RECOMBINANT PROTECTIVE ANTIGEN; CARBOXY-TERMINAL DOMAIN; HUMAN-ANTIBODY RESPONSE; LETHAL FACTOR CLEAVES; NECROSIS-FACTOR-ALPHA; POLY-GAMMA-GLUTAMATE; INHALATIONAL ANTHRAX; DENDRITIC CELLS; IMMUNE-RESPONSE; EDEMA-TOXIN AB Bacillus anthracis is the causative agent of anthrax, a disease that plagues both humans and various animal species. Effective vaccines are available, but those approved for human use are crude culture supernatants that require multiple injections and a yearly boost. Many experts agree that it is now time for the next generation of human vaccines against anthrax. Accordingly, this review will succinctly focus upon: pathogenesis of B. anthracis, with particular emphasis upon the immune system; the pertinent biophysical nature of protective antigen, which includes how the protein toxin component affords protection as a vaccine target; alternative methods for improving protective antigen as an immunogen; and additional B. anthracis antigens that might further sustain protective titers in humans. In addition to a better understanding of the disease process elicited by B. anthracis, which will logically lead to better vaccines (and therapeutics), there also needs to be the same level of open-mindedness applied to the politics of anthrax. C1 [Tournier, Jean-Nicolas; Quesnel-Hellmann, Anne] CRSSA, Unite Interact Hote Pathogene, Dept Biol Agents Transmissibles, F-38702 La Tronche, France. [Ulrich, Robert G.; Stiles, Bradley G.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Mohamadzadeh, Mansour] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. RP Tournier, JN (reprint author), CRSSA, Unite Interact Hote Pathogene, Dept Biol Agents Transmissibles, BP 87, F-38702 La Tronche, France. EM jntournier@crssa.net; robert.ulrich@amedd.army.mil; aquesnel@crssa.net; m.zadeh@northwestern.edu; bradley.stiles@amedd.army.mil RI Quesnel-Hellmann, anne/M-7696-2014 OI Quesnel-Hellmann, anne/0000-0002-7589-8834 NR 185 TC 34 Z9 38 U1 2 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1478-7210 EI 1744-8336 J9 EXPERT REV ANTI-INFE JI Expert Rev. Anti-Infect. Ther. PD MAR PY 2009 VL 7 IS 2 BP 219 EP 236 DI 10.1586/14787210.7.2.219 PG 18 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 418AS UT WOS:000264120200020 PM 19254170 ER PT J AU Hill, MJ McWilliams, GDE Miller, KA Scott, RT Frattarelli, JL AF Hill, Micah J. McWilliams, Grant D. E. Miller, Kathleen A. Scott, Richard T., Jr. Frattarelli, John L. TI A luteal estradiol protocol for anticipated poor-responder patients may improve delivery rates SO FERTILITY AND STERILITY LA English DT Article DE Poor responders; IVF outcome; luteal phase; estradiol; embryo morphology; oocytes; pregnancy; microdose flare; GnRH antagonist ID IN-VITRO FERTILIZATION; CONTROLLED OVARIAN HYPERSTIMULATION; ANTRAL FOLLICLES; EMBRYO-TRANSFER; STIMULATION; GROWTH; CYCLES; MANAGEMENT; ANTAGONIST; FLARE AB Objective: To compare IVF data and outcomes between a standard protocol and a luteal phase E(2) protocol. Design: Retrospective cohort analysis. Setting(s): Large academic assisted reproduction technologies center. Patient(S): Fifty-seven infertile patients with a history of poor response to IVF stimulation and 228 matched control patients. Intervention(s): IVF with a standard protocol or a luteal phase E(2) protocol. Main Outcome Measure(s): Live-birth rates. Result(s): Patients in the luteal E(2) protocol required more days of stimulation and total gonadotropins and had higher peak E(2) levels when compared with the control group. The luteal E(2) protocol showed a greater percentage of embryos with >= 7 cells on day 3. A trend toward improved delivery rates was seen in the luteal E(2) protocol (28.1% vs. 22.4%; relative risk, 1.25, 0.78-2.03). Conclusion(S): A luteal E(2) protocol results in improved day 3 embryo development as demonstrated by the percent of embryos at the >= 7-cell stage. Likewise, the luteal E(2) protocol may ultimately improve pregnancy outcomes for patients with poor response to IVF stimulation. (Fertil Steril (R) 2009;91:739-43. (C) 2009 by American Society for Reproductive Medicine.) C1 [Miller, Kathleen A.; Scott, Richard T., Jr.; Frattarelli, John L.] Reprod Med Associates New Jersey, Morristown, NJ USA. [Hill, Micah J.] Blanchfield Army Community Hosp, Ft Campbell, KY USA. [McWilliams, Grant D. E.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Frattarelli, JL (reprint author), Robert Wood Johnson Med Sch, 100 Franklin Sq Dr,Suite 200, Somerset, NJ 08873 USA. EM jfrattarelli@rmanj.com RI Hill, Micah/A-6777-2009 NR 21 TC 17 Z9 18 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD MAR PY 2009 VL 91 IS 3 BP 739 EP 743 DI 10.1016/j.fertnstert.2007.12.073 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 418JC UT WOS:000264143500015 PM 18314123 ER PT J AU Xu, Q Pichichero, ME Simpson, LL Elias, M Smith, LA Zeng, M AF Xu, Q. Pichichero, M. E. Simpson, L. L. Elias, Md Smith, L. A. Zeng, M. TI An adenoviral vector-based mucosal vaccine is effective in protection against botulism SO GENE THERAPY LA English DT Article DE botulinum neurotoxin; mucosal vaccine; protective immunity; replication-incompetent adenovirus ID HUMORAL IMMUNE-RESPONSES; NEUROTOXIN SEROTYPE-A; CLOSTRIDIUM-BOTULINUM; BINDING DOMAIN; CHOLERA-TOXIN; RECOMBINANT ADENOVIRUSES; CANDIDATE VACCINE; ANTIBODY-RESPONSE; INFLUENZA VACCINE; PICHIA-PASTORIS AB A replication-incompetent adenoviral vector encoding the heavy chain C-fragment (H(C)50) of botulinum neurotoxin type C (BoNT/C) was evaluated as a mucosal vaccine against botulism in a mouse model. Single intranasal inoculation of the adenoviral vector elicited a high level of H(C)50-specific IgG, IgG1 and IgG2a in sera and IgA in mucosal secretions as early as 2 weeks after vaccination. The antigen-specific serum antibodies were maintained at a high level at least until the 27th week. Immune sera showed high potency in neutralizing BoNT/C as indicated by in vitro toxin neutralization assay. The mice receiving single dose of 2 x 10(7) p.f.u. (plaque-forming unit) of adenoviral vector were completely protected against challenge with up to 10(4) x MLD(50) of BoNT/C. The protective immunity showed vaccine dose dependence from 105 to 2 x 10(7) p.f.u. of adenoviral vector. In addition, animals receiving single intranasal dose of 2 x 10(7) p.f.u. adenoviral vector could be protected against 100 x MLD(50) 27 weeks after vaccination. Animals with preexisting immunity to adenovirus could also be vaccinated intranasally and protected against lethal challenge with BoNT/C. These results suggest that the adenoviral vector is a highly effective gene-based mucosal vaccine against botulism. C1 [Xu, Q.; Pichichero, M. E.; Zeng, M.] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA. [Simpson, L. L.; Elias, Md] Thomas Jefferson Univ, Jefferson Med Coll, Dept Biochem & Mol Biol, Philadelphia, PA 19107 USA. [Simpson, L. L.; Elias, Md] Thomas Jefferson Univ, Dept Med, Philadelphia, PA 19107 USA. [Smith, L. A.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD USA. RP Zeng, M (reprint author), Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, 601 Elmwood Ave,Box 672, Rochester, NY 14642 USA. EM Mingtao_Zeng@urmc.rochester.edu RI Xu, Qingfu/A-1597-2011 OI Xu, Qingfu/0000-0002-1957-8502 FU National Institute of Allergy and Infectious Diseases [AI055946]; National Institutes of Health [NO1-AI30028, NS022153, GM57345] FX This work was supported by the US Public Service research Grant AI055946 (MZ) from the National Institute of Allergy and Infectious Diseases. ME and LLS were supported by National Institutes of Health Contract NO1-AI30028, Grants NS022153 and GM57345. We are grateful to Eric D Hesek for constructing and purifying the adenoviral vectors. NR 54 TC 24 Z9 24 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0969-7128 J9 GENE THER JI Gene Ther. PD MAR PY 2009 VL 16 IS 3 BP 367 EP 375 DI 10.1038/gt.2008.181 PG 9 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 417ZB UT WOS:000264115900008 PM 19129860 ER PT J AU Havrilesky, LJ Maxwell, GL Chan, JK Myers, ER AF Havrilesky, Laura J. Maxwell, G. Larry Chan, John K. Myers, Evan R. TI Cost effectiveness of a test to detect metastases for endometrial cancer SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Endometrial cancer; Lymph node metastasis; Diagnostic test; Cost effectiveness; Gynecologic Oncologist ID GYNECOLOGIC-ONCOLOGY-GROUP; LYMPH-NODE METASTASIS; CORPUS CANCER; CARCINOMA; SURVIVAL; RESECTION; DETERMINANTS; RADIOTHERAPY AB Objective. To estimate the potential cost-effectiveness of a hypothetical test to screen for lymph node metastases in women with newly diagnosed, apparent early stage endometrial cancer. Methods. A decision model was constructed to inform a choice between the following strategies: (I) Usual care, in which the probability of undergoing full surgical staging (29%) is based on literature review; (2) Noninvasive diagnostic testing for metastasis (Testing), in which patients with abnormal test results undergo full surgical staging; (3) 100% referral, in which all patients are referred for full surgical staging. Survival was modeled using Surveillance Epidemiology and End Results (SEER) database. Base case diagnostic test characteristic estimates (sensitivity 0.90, specificity 0.90) were varied for sensitivity analysis. Cost of the diagnostic test was set at $500 and varied; costs of treatment for endometrial cancer (surgery, adjuvant therapies, diagnosis of recurrence, salvage therapies and palliative care) were incorporated. Results. Usual care was the least expensive strategy, while Testing was more expensive and more effective, with an incremental cost-effectiveness ratio (ICER) of $18,785 per year of life saved (YLS) compared to Usual care. 100% referral was the most expensive and most effective strategy, with an ICER of $35,358 per YLS compared to Testing. Results are relatively sensitive to variation in test characteristics and the cost of the diagnostic test but insensitive to cost of treatment and probability of adjuvant therapies. Testing remains cost-effective compared to Usual care unless the usual rate of referral to a Gynecologic Oncologist for full staging exceeds 90%. Conclusions. Given the current low rates of full surgical staging and/or referral to a Gynecologic Oncologist, a diagnostic test to detect nodal metastasis for endometrial cancer has potential to be costeffective when compared to usual care. Testing is also potentially cost-effective compared to 100% referral at very high test sensitivities and at the lower range of test costs. (C) 2008 Elsevier Inc. All rights reserved. C1 [Havrilesky, Laura J.] Duke Univ, Med Ctr, Div Gynecol Oncol, Durham, NC 27710 USA. [Myers, Evan R.] Duke Univ, Med Ctr, Div Clin & Epidemiol Res, Durham, NC 27710 USA. [Havrilesky, Laura J.; Myers, Evan R.] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA. [Havrilesky, Laura J.; Myers, Evan R.] Duke Univ, Med Ctr, Duke Comprehens Canc Ctr, Durham, NC 27710 USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Maxwell, G. Larry] United States Mil Canc Inst, Washington, DC USA. [Maxwell, G. Larry] NCI, Lab Biosyst & Canc, Bethesda, MD 20892 USA. [Chan, John K.] Univ Calif San Francisco, Div Gynecol Oncol, San Francisco, CA 94143 USA. [Chan, John K.] Univ Calif San Francisco, Dept Obstet & Gynecol, San Francisco, CA 94143 USA. [Chan, John K.] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA. RP Havrilesky, LJ (reprint author), Box 3079 DUMC, Durham, NC 27710 USA. EM havri001@mc.duke.edu FU American Board of Obstetrics and Gynecology; American Association of Obstetricians and Gynecologists Foundation. FX LH is supported by a grant from the American Board of Obstetrics and Gynecology/American Association of Obstetricians and Gynecologists Foundation. NR 19 TC 3 Z9 3 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2009 VL 112 IS 3 BP 526 EP 530 DI 10.1016/j.ygyno.2008.11.017 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 418QH UT WOS:000264162800018 PM 19100608 ER PT J AU Szrom, F Falo, GA Parkhurst, MA Whicker, JJ Alberth, DP AF Szrom, Frances Falo, Gerald A. Parkhurst, Mary Ann Whicker, Jeffrey J. Alberth, David P. TI CALCULATING CAPSTONE DEPLETED URANIUM AEROSOL CONCENTRATIONS FROM BETA ACTIVITY MEASUREMENTS SO HEALTH PHYSICS LA English DT Article DE beta particles; counting efficiency; radioactivity, airborne; uranium, depleted AB Beta activity measurements were used as surrogate measurements of uranium mass in aerosol samples collected during the field testing phase of the Capstone Depleted Uranium (DU) Aerosol Study. These aerosol samples generated by the perforation of armored combat vehicles were used to characterize the DU source term for the subsequent Human Health Risk Assessment (HHRA) of Capstone aerosols. Establishing a calibration curve between beta activity measurements and uranium mass measurements is straightforward if the uranium isotopes are in equilibrium with their immediate short-lived, beta-emitting progeny. For DU samples collected during the Capstone study, it was determined that the equilibrium between the uranium isotopes and their immediate short-lived, beta-emitting progeny had been disrupted when penetrators had perforated target vehicles. Adjustments were made to account for the disrupted equilibrium and for wall losses in the aerosol samplers. Values for the equilibrium fraction ranged from 0.16 to 1, and the wall loss correction factors ranged from 1 to 1.92. This paper describes the process used and adjustments necessary to calculate uranium mass from proportional counting measurements. C1 [Szrom, Frances; Falo, Gerald A.; Alberth, David P.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Parkhurst, Mary Ann] Pacific NW Natl Lab, Richland, WA 99352 USA. [Whicker, Jeffrey J.] Los Alamos Natl Lab, Los Alamos, NM 87544 USA. RP Szrom, F (reprint author), USA, Ctr Hlth Promot & Prevent Med, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM fran.szrom@us.army.mil FU U.S. Office of the Special Assistant for Gulf War Illnesses, Medical Readiness and Military Deployment (OSAGWI); U.S. Army FX The authors would like to thank the ATC Health Physics Laboratory, in particular Julie Long, and the USACHPPM Laboratory staff, in particular David Morrow, Ronald Swatski, Thomas Beegle, and Angel Christman. We also want to thank John Collins for his invaluable assistance with the sample loss evaluation. Technical reviews were conducted by Mr. Don Bihl and Dr. Joseph McDonald (ret.) of Pacific Northwest National Laboratory. Funding was provided by the U.S. Office of the Special Assistant for Gulf War Illnesses, Medical Readiness and Military Deployment (OSAGWI, currently referred to as Force Health Protection & Readiness Policy & Programs) and the U.S. Army. NR 9 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAR PY 2009 VL 96 IS 3 BP 238 EP 250 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 407DD UT WOS:000263342900003 PM 19204483 ER PT J AU Krupka, KM Parkhurst, MA Gold, K Arey, BW Jenson, ED Guilmette, RA AF Krupka, Kenneth M. Parkhurst, Mary Ann Gold, Kenneth Arey, Bruce W. Jenson, Evan D. Guilmette, Raymond A. TI PHYSICOCHEMICAL CHARACTERIZATION OF CAPSTONE DEPLETED URANIUM AEROSOLS III: MORPHOLOGIC AND CHEMICAL OXIDE ANALYSES SO HEALTH PHYSICS LA English DT Article DE aerosols; contamination, environmental; uranium, depleted; radioactivity, airborne ID OXIDATION-STATES; PARTICLES; KOSOVO; PENETRATORS; TANK AB The impact of depleted uranium (DU) penetrators against an armored target causes erosion and fragmentation of the penetrators, the extent of which is dependent on the thickness and material composition of the target. Vigorous oxidation of the DU particles and fragments creates an aerosol of DU oxide particles and DU particle agglomerations combined with target materials. Aerosols from the Capstone DU aerosol study, in which vehicles were perforated by DU penetrators, were evaluated for their oxidation states using x-ray diffraction (XRD), and particle morphologies were examined using scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS). The oxidation state of a DU aerosol is important as it offers a clue to its solubility in lung fluids. The XRD analysis showed that the aerosols evaluated were a combination primarily of U3O8 (insoluble) and UO3 (relatively more soluble) phases, though intermediate phases resembling U4O9 and other oxides were prominent in some samples. Analysis of particle residues in the micrometer-size range by SEM/EDS provided microstructural information such as phase composition and distribution, fracture morphology, size distribution, and material homogeneity. Observations from SEM analysis show a wide variability in the shapes of the DU particles. Some of the larger particles were spherical, occasionally with dendritic or lobed surface structures. Others appear to have fractures that perhaps resulted from abrasion and comminution, or shear bands that developed from plastic deformation of the DU material. Amorphous conglomerates containing metals other than uranium were also common, especially with the smallest particle sizes. A few samples seemed to contain small bits of nearly pure uranium metal, which were verified by EDS to have a higher uranium content exceeding that expected for uranium oxides. Results of the XRD and SEM/EDS analyses were used in other studies described in this issue of Health Physics to interpret the results of lung solubility studies and in selecting input parameters for dose assessments. C1 [Krupka, Kenneth M.; Parkhurst, Mary Ann; Arey, Bruce W.; Jenson, Evan D.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Gold, Kenneth] USA, RDECOMARDEC, Picatinny Arsenal, NJ 07806 USA. [Guilmette, Raymond A.] Lovelace Resp Res Inst, Albuquerque, NM 87108 USA. RP Krupka, KM (reprint author), Pacific NW Natl Lab, POB 999,K6-81, Richland, WA 99352 USA. EM ken.krupka@pnl.gov FU U.S. Office of the Special Assistant for Gulf War Illnesses, Medical Readiness and Military Deployment (OSAGWI); U.S. Army; U.S. Department of Energy [DE-AC05-76RL01830] FX The authors thank H. Todd Schaef for his thorough review and helpful comments. We also thank Dr. Larry Thomas for his advice regarding the interpretation of particles evaluated using SEM/EDS, and to Drs. Lee Magness and Joseph McDonald for their reviews. The Capstone DU Aerosol Study was jointly supported by the U.S. Office of the Special Assistant for Gulf War Illnesses, Medical Readiness and Military Deployment (OSAGWI, currently referred to as Force Health Protection & Readiness Policy & Programs) and the U.S. Army. The Pacific Northwest National Laboratory (PNNL) is operated by Battelle for the U.S. Department of Energy under contract DE-AC05-76RL01830. NR 30 TC 14 Z9 14 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAR PY 2009 VL 96 IS 3 BP 276 EP 291 PG 16 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 407DD UT WOS:000263342900006 PM 19204486 ER PT J AU Roszell, LE Hahn, FF Lee, RB Parkhurst, MA AF Roszell, Laurie E. Hahn, Fletcher F. Lee, Robyn B. Parkhurst, Mary Ann TI ASSESSING THE RENAL TOXICITY OF CAPSTONE DEPLETED URANIUM OXIDES AND OTHER URANIUM COMPOUNDS SO HEALTH PHYSICS LA English DT Article DE uranium, depleted; kidneys; modeling, dose assessment; risk estimates ID GULF-WAR VETERANS; FOLLOW-UP; URANYL; RAT; NEPHROTOXICITY; CELLS AB The primary target for uranium toxicity is the kidney. The most frequently used guideline for uranium kidney burdens is the International Commission on Radiological Protection value of 3 mu g U g(-1) kidney, a value that is based largely upon chronic studies in animals. In the present effort, a risk model equation was developed to assess potential outcomes of acute uranium exposure. Twenty-seven previously published case studies in which workers were acutely exposed to soluble compounds of uranium (as a result of workplace accidents) were analyzed. Kidney burdens of uranium for these individuals were determined based on uranium in the urine, and correlated with health effects observed over a period of up to 38 years. Based upon the severity of health effects, each individual was assigned a score (- to + + +) and then placed into it Renal Effects Group (REG). A discriminant analysis was used to build it model equation to predict the REG based on the amount of uranium in the kidneys. The model equation was able to predict the REG, with 85% accuracy. The risk model was used to predict the REG for soldiers exposed to depleted uranium as a result of friendly fire incidents during the 1991 Gulf War. This model equation can also be used to predict the REG of new cases in which acute exposures to uranium have occurred. C1 [Roszell, Laurie E.; Lee, Robyn B.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Hahn, Fletcher F.] Lovelace Resp Res Inst, Albuquerque, NM 87105 USA. [Parkhurst, Mary Ann] Pacific NW Natl Lab, Richland, WA 99352 USA. RP Roszell, LE (reprint author), USA, Ctr Hlth Promot & Prevent Med, 5159 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM laurie.roszell@us.army.mil FU U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM), Aberdeen, MD FX The authors want to thank Raymond Guilmette, Guthrie Miller. and Thomas Little for the dose modeling that provided the predicted kidney uranium concentrations, and Eric Daxon, Gerald Falo, Fran Szrom and LTC Gordon Lodde (USA-Ret.) for reviews of early versions of this manuscript. Funding was provided by the U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM), Aberdeen, MD. NR 34 TC 11 Z9 11 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAR PY 2009 VL 96 IS 3 BP 343 EP 351 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 407DD UT WOS:000263342900010 PM 19204490 ER PT J AU Hahn, FF Roszell, LE Daxon, EG Guilmette, RA Parkhurst, MA AF Hahn, Fletcher F. Roszell, LaLtrie E. Daxon, Eric G. Guilmette, Raymond A. Parkhurst, Mary Ann TI RADIOLOGICAL RISK ASSESSMENT OF CAPSTONE DEPLETED URANIUM AEROSOLS SO HEALTH PHYSICS LA English DT Article DE radiation risk; health effects; uranium, depleted; inhalation ID LUNG-CANCER RISK; NATURAL URANIUM; EXPOSURE; TISSUES; RADIONUCLIDES; INHALATION; ISOTOPES; DUST AB Assessment of the health risk from exposure to aerosols of depleted uranium (DU) is an important outcome of the Capstone aerosol studies that established exposure ranges to personnel in armored combat vehicles perforated by DU munitions. Although the radiation exposure from DU is low, there is concern that DU deposited in the body may increase cancer rates. Radiation doses to various organs of the body resulting from the inhalation of DU aerosols measured in the Capstone studies were calculated using International Commission on Radiological Protection (ICRP) models. Organs and tissues with the highest calculated committed equivalent 50-y doses were lung and extrathoracic tissues (nose and nasal passages, pharynx, larynx, mouth, and thoracic lymph nodes). Doses to the bone surface and kidney were about 5 to 10% of the doses to the extrathoracic tissues. Organ-specific risks were estimated using ICRP and U.S. Environmental Protection Agency (EPA) methodologies. Risks for crewmembers and first responders were determined for selected scenarios based on the time interval of exposure and for vehicle and armor type. The lung was the organ with the highest cancer mortality risk, accounting for about 97% of the risks summed from all organs. The highest mean lifetime risk for lung cancer for the scenario with the longest exposure time interval (2 h) was 0.42%. This risk is low compared with the natural or background risk of 7.35%. These risks can be significantly reduced by using an existing ventilation system (if operable) and by reducing personnel time in the vehicle immediately after perforation. C1 [Hahn, Fletcher F.; Guilmette, Raymond A.] Lovelace Resp Res Inst, Albuquerque, NM 87105 USA. [Roszell, LaLtrie E.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Daxon, Eric G.] Battelle Mem Inst, San Antonio, TX 78228 USA. [Parkhurst, Mary Ann] Pacific NW Natl Lab, Richland, WA 99352 USA. RP Hahn, FF (reprint author), Lovelace Resp Res Inst, 2425 Ridgecrest Dr SE, Albuquerque, NM 87105 USA. EM fhahn@LLRI.org FU U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM), Aberdeen, MD FX Funding and technical guidance were provided by the U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM), Aberdeen, MD. NR 45 TC 6 Z9 6 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAR PY 2009 VL 96 IS 3 BP 352 EP 362 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 407DD UT WOS:000263342900011 PM 19204491 ER PT J AU Szrom, F Falo, GA Lodde, GM Parkhurst, MA Daxon, EG AF Szrom, Frances Falo, Gerald A. Lodde, Gordon M. Parkhurst, Mary Ann Daxon, Eric G. TI INHALATION AND INGESTION INTAKES WITH ASSOCIATED DOSE ESTIMATES FOR LEVEL II AND LEVEL III PERSONNEL USING CAPSTONE STUDY DATA SO HEALTH PHYSICS LA English DT Article DE ingestion; inhalation; radioactivity, airborne; uranium, depleted ID HAND EXPOSURE AB Depleted uranium (DU) intake rates and subsequent dose rates were estimated for personnel entering armored combat vehicles perforated with DU penetrators (level II and level III personnel) using data generated during the Capstone DU Aerosol Study. Inhalation intake rates and associated dose rates were estimated from cascade impactors worn by sample recovery personnel and from cascade impactors that served as area monitors. Ingestion intake rates and associated dose rates were estimated from cotton gloves worn by sample recovery personnel and from wipe-tests samples from the interior of vehicles perforated with large-caliber DU munitions. The mean DU inhalation intake rate for level II personnel ranged from 0.447 mg h(-1) based on breathing zone monitor data (in and around a perforated vehicle) to 14.5 rug h(-1) based on area monitor data (in a perforated vehicle). The mean DU ingestion intake rate for level II ranged from 4.8 mg h(-1) to 38.9 mg h(-1) based on the wipe-tests data including surface-to-glove transfer factors derived from the Capstone data. Based on glove contamination data, the mean DU ingestion intake rates for level II and level III personnel were 10.6 mg h(-1) and 1.78 mg h(-1), respectively. Effective dose rates and peak kidney uranium concentration rates were calculated based on the intake rates. The peak kidney uranium concentration rate cannot be multiplied by the total exposure duration when multiple intakes occur because uranium will clear from the kidney between the exposures. C1 [Szrom, Frances; Falo, Gerald A.; Lodde, Gordon M.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Parkhurst, Mary Ann] Pacific NW Natl Lab, Richland, WA 99352 USA. [Daxon, Eric G.] Battelle Columbus Operat, San Antonio, TX 78228 USA. RP Szrom, F (reprint author), USA, Ctr Hlth Promot & Prevent Med, 5158 Blackliawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM fran.szrom@us.army.mil NR 22 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAR PY 2009 VL 96 IS 3 BP 363 EP 379 PG 17 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 407DD UT WOS:000263342900012 PM 19204492 ER PT J AU Daxon, EG Parkhurst, MA Melanson, MA Roszell, LE AF Daxon, Eric G. Parkhurst, Mary Ann Melanson, Mark A. Roszell, Laurie E. TI APPLICATIONS OF CAPSTONE DEPLETED URANIUM AEROSOL RISK DATA TO MILITARY COMBAT RISK MANAGEMENT SO HEALTH PHYSICS LA English DT Article DE aerosols; uranium, depleted; inhalation; risk analysis AB Risks to personnel engaged in military operations include not only the threat of enemy firepower but also risks from exposure to other hazards such as radiation. Combatant commanders of the U.S. Army carefully weigh risks of casualties before implementing battlefield actions using an established paradigm that takes these risks into consideration. As a result of the inclusion of depleted uranium (DU) anti-armor ammunition in the conventional (non-nuclear) weapons arsenal, the potential for exposure to DU aerosols and its associated chemical and radiological effects becomes an element of the commanders' risk assessment. The Capstone DU Aerosol Study measured the range of likely DU oxide aerosol concentrations created inside a combat vehicle perforated with a DU munition, and the Capstone Human Health Risk Assessment (HHRA) estimated the associated doses and calculated risks. This paper focuses on the development of a scientific approach to adapt the risks from DU's non-uniform dose distribution within the body using the current U.S. Department of Defense radiation risk management approach. The approach developed equates the Radiation Exposure Status categories to the estimated radiological risks of DU and makes use of the Capstone-developed Renal Effects Group as a measure of chemical risk from DU intake. Recommendations are provided for modifying Army guidance and policy in order to better encompass the potential risks from DU aerosol inhalation during military operations. C1 [Daxon, Eric G.] Battelle San Antonio Operat, San Antonio, TX 78228 USA. [Parkhurst, Mary Ann] Pacific NW Natl Lab, Richland, WA 99352 USA. [Melanson, Mark A.] USA, Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Roszell, Laurie E.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Daxon, EG (reprint author), Battelle San Antonio Operat, 4100 Piedras Dr E,Suite 185, San Antonio, TX 78228 USA. EM daxone@battelle.org FU U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM), Aberdeen, MD FX The author wish to thank Raymond A. Guilmette and Chad B. McKee for their ideas and guidance, Fletcher Hahn and Robyn Lee for their assistance with the development of the Renal Effects Groups, and reviews by Fran Szrom, Gerald Falo, David Alberth, Donald Bihl, and Joseph McDonald. Funding was provided by the U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM), Aberdeen, MD. NR 35 TC 1 Z9 1 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAR PY 2009 VL 96 IS 3 BP 380 EP 392 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 407DD UT WOS:000263342900013 PM 19204493 ER PT J AU Vorontsov, MA Weyrauch, T Beresnev, LA Carhart, GW Liu, L Aschenbach, K AF Vorontsov, Mikhail A. Weyrauch, Thomas Beresnev, Leonid A. Carhart, Gary W. Liu, Ling Aschenbach, Konley TI Adaptive Array of Phase-Locked Fiber Collimators: Analysis and Experimental Demonstration SO IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS LA English DT Article DE Adaptive optics (AO); optical arrays; optical beams; phased arrays ID LASER-BEAM PROJECTION; WAVE-FRONT CONTROL; ATMOSPHERIC COMPENSATION; DISTORTION CORRECTION; OPTIMIZATION; TURBULENCE; OPTICS AB We discuss development and integration of a coherent fiber array system composed of densely packed fiber collimators with built-in capabilities for adaptive wavefront phase piston and tilt control at each fiber collimator. In this system, multi-channel fiber-integrated phase shifters are used for phase locking of seven fiber collimators and the precompensation of laboratory-generated turbulence-induced phase aberrations. Controllable x and y displacements of the fiber tips in the fiber collimator array provide additional adaptive compensation of the tip and tilt phase aberration components. An additional control system is utilized for equalization of the intensity of each of the fiber collimator beams. All three control systems are based on the stochastic parallel gradient descent optimization technique. The paper presents the first experimental results of adaptive dynamic phase distortion compensation with an adaptive phase-locked fiber collimator array system. C1 [Vorontsov, Mikhail A.; Beresnev, Leonid A.; Carhart, Gary W.; Aschenbach, Konley] USA, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD 20783 USA. [Vorontsov, Mikhail A.; Weyrauch, Thomas; Liu, Ling] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA. RP Vorontsov, MA (reprint author), USA, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD 20783 USA. EM mvorontsov@arl.army.mil; weyrauch@umd.edu; lberesnev@arl.army.mil; gcarhart@arl.army.mil; liuling@umd.edu; konley.aschenbach@arl.army.mil FU Defense Advanced Research Projects Agency (DARPA); Joint Technology Office; Cooperative Agreements between Army Research Laboratory (ARL); University of Maryland, College Park [W911NF-06-2-0009, W911NF-07-2-0009] FX This work was supported in part by the Defense Advanced Research Projects Agency (DARPA) and the Joint Technology Office and by the Cooperative Agreements between Army Research Laboratory (ARL) and the University of Maryland, College Park, under Contracts W911NF-06-2-0009 and W911NF-07-2-0009. NR 25 TC 78 Z9 88 U1 4 U2 16 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1077-260X EI 1558-4542 J9 IEEE J SEL TOP QUANT JI IEEE J. Sel. Top. Quantum Electron. PD MAR-APR PY 2009 VL 15 IS 2 BP 269 EP 280 DI 10.1109/JSTQE.2008.2010875 PG 12 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 435WB UT WOS:000265372900005 ER PT J AU Clark, OE Nealley, EW Miller, AL Jung, YS Smith, WJ AF Clark, O. E. Nealley, E. W. Miller, A. L. Jung, Y. -S. Smith, W. J. TI Human Bronchial Epithelial Cells as a Model for Human Lung Airway Injury and Therapeutic Intervention Following Sulfur Mustard Exposure In Vitro. SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Clark, O. E.; Nealley, E. W.; Miller, A. L.; Smith, W. J.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Jung, Y. -S.] Korea Res Inst Chem Technol, Taejon 305606, South Korea. EM offie.clark@us.army.mil; William.j.smith3@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2009 VL 45 BP S45 EP S45 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 481ZS UT WOS:000268853400117 ER PT J AU Gross, VCL Nealley, EW Miller, AL Nipwoda, MT Clark, OE Smith, WJ AF Gross, Vx C. L. Nealley, E. W. Miller, A. L. Nipwoda, M. T. Clark, O. E. Smith, W. J. TI Lack of Genotoxicity in Cultured Human Small Airway and Microvascular Cells Following Exposure to the Nerve Agent. SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Gross, Vx C. L.; Nealley, E. W.; Miller, A. L.; Nipwoda, M. T.; Clark, O. E.; Smith, W. J.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. EM clark.gross@us.army.mil; William.j.smith3@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2009 VL 45 BP S45 EP S45 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 481ZS UT WOS:000268853400118 ER PT J AU Miller, AL Gross, CL Nealley, EW Clark, OE Waraich, NK Rodgers, KL Smith, WJ AF Miller, A. L. Gross, C. L. Nealley, E. W. Clark, O. E. Waraich, N. K. Rodgers, K. L. Smith, W. J. TI Use of Cultured Human Skin Cells and a Skin Tissue Construct as Models to Study the Genotoxic Marker gamma-H2AX Following Sulfur Mustard Exposure. SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Miller, A. L.; Gross, C. L.; Nealley, E. W.; Clark, O. E.; Waraich, N. K.; Rodgers, K. L.; Smith, W. J.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. EM adele.miller@us.army.mil; William.j.smith3@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD SPR PY 2009 VL 45 BP S44 EP S45 PG 2 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 481ZS UT WOS:000268853400116 ER PT J AU Grujicic, M Pandurangan, B Coutris, N Cheeseman, BA Fountzoulas, C Patel, P Templeton, DW Bishnoi, KD AF Grujicic, M. Pandurangan, B. Coutris, N. Cheeseman, B. A. Fountzoulas, C. Patel, P. Templeton, D. W. Bishnoi, K. D. TI A simple ballistic material model for soda-lime glass SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Transparent armor; Material modeling; Ballistic performance; Soda-lime glass ID BRITTLE MATERIALS; FRAGMENTATION; DAMAGE AB Various open-literature experimental findings pertaining to the ballistic behavior of glass are used to construct a simple, physically based, high strain-rate, high-pressure, large-strain constitutive model for this material. The basic components of the model are constructed in such a way that the model is suitable for direct incorporation into standard commercial transient non-linear dynamics finite-element based software packages like ANSYS/Autodyn [ANSYS/Autodyn version 11.0, User documentation, Century Dynamics Inc. a subsidiary of ANSYS Inc.; 2007.] or ABAQUS/Explicit [ABAQUS version 6.7, User documentation, Dessault systems, 2007.]. To validate the material model, a set of finite element analyses of the Edge-on-Impact (EOI) tests is carried out and the results compared with their experimental counterparts obtained in the recent work of Strassburger et al. [Strassburger E, Patel P, McCauley JW, Kovalchick C, Ramesh KT Templeton DW. High-speed transmission shadowgraphic and dynamic photoelasticity study of stress wave and impact damage propagation in transparent materials and laminates using the edge-on impact method. In: Proceedings of the twenty-third international symposium on ballistics. Spain: April 2007, and Strassburger E, Patel P, McCauley W, Templeton DW. Visualization of wave propagation and impact damage in a polycrystalline transparent ceramic-AION. In: Proceedings of the twenty-second international symposium on ballistics. Vancouver, Canada: November 2005.]. Overall, a good agreement is found between the computational and the experimental results pertaining to: (a) the front-shapes and propagation velocities of the longitudinal and transverse waves generated in the target during impact; (b) the front-shapes and propagation velocities of the "coherent-damage" zone (a zone surrounding the projectile/target contact surface which consists of numerous micron- and submicron-size cracks); and (c) the formation of "crack centers", i.e. isolated cracks nucleated ahead of the advancing coherent-damage zone front. Relatively minor discrepancies between the computational and the experimental results are attributed to the effects of damage-promoting target-fixturing induced stresses and cutting/grinding-induced flaws located along the narrow faces of the target and the surrounding regions. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Grujicic, M.; Pandurangan, B.; Coutris, N.] Clemson Univ, Dept Mech Engn, ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.; Fountzoulas, C.; Patel, P.] USA, Res Lab, Survivabil Mat Branch, Proving Ground, MD 21005 USA. [Templeton, D. W.; Bishnoi, K. D.] USA, TARDEC, AMSRD TAR RMS 263, Warren, MI 48397 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, ICAR, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu NR 21 TC 22 Z9 23 U1 3 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAR PY 2009 VL 36 IS 3 BP 386 EP 401 DI 10.1016/j.ijimpeng.2008.08.001 PG 16 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 392YU UT WOS:000262338900003 ER PT J AU Waxman, S Beekley, A Morey, A Soderdahl, D AF Waxman, S. Beekley, A. Morey, A. Soderdahl, D. TI Penetrating trauma to the external genitalia in Operation Iraqi Freedom SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH LA English DT Article DE trauma; genitalia; testicle; penis; scrotum ID UROGENITAL INJURIES; WAR INJURIES; EXPERIENCE; WOUNDS AB This report details the incidence and description of trauma to the external genitalia experienced during Operation Iraqi Freedom at a United States Army Combat Support Hospital, and demonstrates that acceptable rates of testicular salvage are possible in the combat setting. The operating room logs and the Joint Theater Trauma Registry were used to conduct a retrospective review of the patients who sustained genitourinary (GU) injuries at an US Army Combat Support Hospital (CSH) in Iraq from 27 February 2007 to 14 August 2007. Of the 3595 battle trauma injuries seen at the CSH during the time period, 168 (4.7%) had one or more GU injuries for a total of 172 GU injuries. Of these patients, 115 (68%) with GU injuries had one or more injuries to the external genitalia for a total of 119 external GU injuries. Penetrating trauma to the penis and scrotum accounted for 59 of the injuries. In total, 43 testicles were injured in 34 patients (9 had bilateral injuries). In total, 32 testes were repaired primarily and 11 were removed. Injuries to the external genitalia continue to account for the vast majority of GU trauma in a combat setting. Of patients who presented with penetrating testicular trauma, there was a 74.4% salvage rate, which is higher than previous reports of combat external genitalia injuries. Treatment of penetrating trauma to the external genitalia in a combat setting requires attention to tissue preservation while coordinating associated surgical procedures. International Journal of Impotence Research ( 2009) 21, 145-148; doi:10.1038/ijir.2008.59; published online 20 November 2008 C1 [Waxman, S.; Soderdahl, D.] Brooke Army Med Ctr, San Antonio, TX USA. [Beekley, A.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Morey, A.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. EM steve-waxman@uiowa.edu NR 16 TC 21 Z9 21 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0955-9930 J9 INT J IMPOT RES JI Int. J. Impot. Res. PD MAR PY 2009 VL 21 IS 2 BP 145 EP 148 DI 10.1038/ijir.2008.59 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 419TS UT WOS:000264243200008 PM 19020522 ER PT J AU Randow, CL Gazonas, GA AF Randow, C. L. Gazonas, G. A. TI Transient stress wave propagation in one-dimensional micropolar bodies SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Microstructures; Stress waves; Plate impact; Anisotropic material ID MICROSTRUCTURED SOLIDS; COMPRESSIONAL WAVE; ACCELERATION-WAVES; RANDOM-MEDIA; OSCILLATIONS; TRANSITION; COLUMN AB Certain types of structures and materials, such as engineered multi-scale systems and comminuted zones in failed ceramics, may be modeled using continuum theories incorporating additional kinematic degrees of freedom beyond the scope of classical continuum theories. If such material systems are to be subjected to high strain rate loads, such as those resulting from ballistic impact or blast, it will be necessary to develop models capable of describing transient stress wave propagation through these media. Such a model is formulated, solved, and applied to the impact between two bodies and to a two-layer bar or strip subjected to an instantaneously applied stress. Results from these examples suggest that the model parameters, and therefore constitutive properties and geometries, may be tuned to reduce and control the transmission of stress through these bodies. Published by Elsevier Ltd. C1 [Randow, C. L.] USA, Res Lab, ATTN AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Randow, CL (reprint author), USA, Res Lab, ATTN AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. EM charles.randow@arl.army.mil OI Gazonas, George/0000-0002-2715-016X FU U.S. Army Research Laboratory Postdoctoral Fellowship Program FX The first author acknowledges that this research was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with U.S. Army Research Laboratory. NR 29 TC 3 Z9 3 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD MAR 1 PY 2009 VL 46 IS 5 BP 1218 EP 1228 DI 10.1016/j.ijsolstr.2008.10.024 PG 11 WC Mechanics SC Mechanics GA 408GC UT WOS:000263422500022 ER PT J AU Katayama, T Kato, T Tanaka, M Douglas, TA Brouchkov, A Fukuda, M Tomita, F Asano, K AF Katayama, Taiki Kato, Tomoko Tanaka, Michiko Douglas, Thomas A. Brouchkov, Anatoli Fukuda, Masami Tomita, Fusao Asano, Kozo TI Glaciibacter superstes gen. nov., sp nov., a novel member of the family Microbacteriaceae isolated from a permafrost ice wedge SO INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY LA English DT Article ID SEQUENCE DATA; TREES; ARB AB Gram-positive, aerobic, non-spore-forming, irregular rod-shaped bacteria, designated strains AHU1791(T) and AHU1810, were isolated from a permafrost ice wedge in Alaska. Cells were motile by means of a polar flagellum. The strains were psychrophilic, growing at -5 to 25 degrees C. Phylogenetic analysis of 16S rRNA gene sequences indicated that the ice-wedge isolates formed a clade distinct from other genera affiliated with the family Microbacteriaceae. The novel strains showed highest levels of 16S rRNA gene sequence similarity with members of the genera Agreia and Subtercola (95.6-95.9%). The level of 16S rRNA gene sequence similarity between strains showed highest levels of 16S rRNA gene sequence similarity with members of the genera Agreia and Subtercola (95.6-95.9%). The level of 16S rRNA gene sequence similarity between strains AHU1791(T) and AHU1810 was 99.8%. The cell-wall peptidoglycan type of the two strains was B2 gamma, containing 2,4-diaminobutyric acid as the diagnostic amino acid. The predominant menaquinones were MK-12 and MK-13 (strain AHU1791(T)) and MK-11 and MK-12 (strain AHU1810). The major fatty acids of the two strains were 12-methyl tetradecanoic acid (anteiso-C(15:0)), 14-methyl hexadecanoic acid (anteiso-C(17:0)), 14-methyl pentadecanoic acid iSO-C(16:0)) and 13-methyl tetradecanoic acid (iso-C(15:0)). The DNA G+C contents of strains AHU1791(T) and AHU1810 were approximately 65 mol%. These phenotypic characteristics differentiated the ice-wedge strains from their closest phylogenetic neighbours, namely Subtercola boreus and the two recognized species of the genus Agreia. The sequences of the housekeeping genes coding for DNA gyrase subunit B (gyrB), RNA polymerase subunit B (rpoB) and recombinase A (recA) were almost identical between strains AHU1791(T) and AHU1810. Although the predominant menaquinones found in strains AHU1791(T) and AHU1810 were different, no other distinct differences were found with regard to other phenotypic and genotypic characteristics, indicating that the two strains were members of the same species. Accordingly, strains AHU1791T and AHU1810 are considered to represent a single novel species of a new genus, for which the name Glaciibacter superstes gen. nov., sp. nov. is proposed. The type strain of Glaciibacter superstes is AHU1791(T) (=DSM 21135(T) =NBRC 104264(T)). C1 [Katayama, Taiki; Kato, Tomoko; Tanaka, Michiko; Asano, Kozo] Hokkaido Univ, Grad Sch Agr, Appl Microbiol Lab, Kita Ku, Sapporo, Hokkaido 0608589, Japan. [Douglas, Thomas A.] Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Brouchkov, Anatoli] Tyumen State Oil & Gas Univ, Siberian Branch, Russian Acad Sci, Tyumen Sci Ctr, Tyumen 625048, Russia. [Fukuda, Masami] Univ Alaska, Int Arctic Res Ctr, Fairbanks, AK 99775 USA. [Tomita, Fusao] Univ Air, Hokkaido Study Ctr, Kita Ku, Chiba, Hokkaido 0600817, Japan. RP Asano, K (reprint author), Hokkaido Univ, Grad Sch Agr, Appl Microbiol Lab, Kita Ku, N9 W9, Sapporo, Hokkaido 0608589, Japan. EM asanok@chem.agr.hokudai.ac.jp RI Tanaka, Michiko/F-5790-2012; ASANO, Kozo/F-6927-2012 FU Institute for Fermentatio, Osaka FX This study was supported in part by a grant from the Institute for Fermentatio, Osaka. NR 27 TC 15 Z9 15 U1 0 U2 3 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1466-5026 J9 INT J SYST EVOL MICR JI Int. J. Syst. Evol. Microbiol. PD MAR PY 2009 VL 59 BP 482 EP 486 DI 10.1099/ijs.0.001354-0 PG 5 WC Microbiology SC Microbiology GA 425VA UT WOS:000264664400006 PM 19244426 ER PT J AU Valentine, T AF Valentine, Timothy TI Philosophy of Education: An Anthology SO INTERNATIONAL PHILOSOPHICAL QUARTERLY LA English DT Book Review C1 [Valentine, Timothy] US Mil Acad, West Point, NY 10996 USA. RP Valentine, T (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU PHILOSOPHY DOCUMENTATION CENTER PI CHARLOTTESVILLE PA PO BOX 7147, CHARLOTTESVILLE, VA 22906-7147 USA SN 0019-0365 J9 INT PHILOS QUART JI Int. Philos. Q. PD MAR PY 2009 VL 49 IS 1 BP 109 EP 112 PG 4 WC Philosophy SC Philosophy GA 428QA UT WOS:000264862600008 ER PT J AU Fleming, S Jordan, T Madden, M Usery, EL Welch, R AF Fleming, S. Jordan, T. Madden, M. Usery, E. L. Welch, R. TI GIS applications for military operations in coastal zones SO ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSING LA English DT Article DE GIS; Coastal mapping; Landscape modeling; Visualization AB In order to successfully support current and future US military operations in coastal zones, geospatial information must be rapidly integrated and analyzed to meet ongoing force structure evolution and new mission directives. Coastal zones in a military-operational environment are complex regions that include sea, land and air features that demand high-volume databases of extreme detail within relatively narrow geographic corridors. Static products in the form of analog maps at varying scales traditionally have been used by military commanders and their operational planners. The rapidly changing battlefield of 21st Century warfare, however, demands dynamic mapping solutions. Commercial geographic information system (GIS) software for military-specific applications is now being developed and employed with digital databases to provide customized digital maps of variable scale, content and symbolization tailored to unique demands of military units. Research conducted by the Center for Remote Sensing and Mapping Science at the University of Georgia demonstrated the utility of GIS-based analysis and digital map creation when developing large-scale (1:10,000) products from littoral warfare databases. The methodology employed-selection of data sources (including high resolution commercial images and Lidar), establishment of analysis/modeling parameters, conduct of vehicle mobility analysis, development of models and generation of products (such as a continuous sea-land DEM and geo-visualization of changing shorelines with tidal levels)-is discussed. Based on observations and identified needs from the National Geospatial-Intelligence Agency, formerly the National imagery and Mapping Agency, and the Department of Defense, prototype GIS models for military operations in sea, land and air environments were created from multiple data sets of a study area at US Marine Corps Base Camp Lejeune, North Carolina. Results of these models, along with methodologies for developing large-scale littoral warfare databases, aid the National Geospatial-Intelligence Agency in meeting littoral warfare analysis, modeling and map generation requirements for US military organizations. (C) 2008 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS). Published by Elsevier B.V. All rights reserved. C1 [Jordan, T.; Madden, M.; Welch, R.] Univ Georgia, Dept Geog, Ctr Remote Sensing & Mapping Sci, Athens, GA 30602 USA. [Fleming, S.] US Mil Acad, Dept Geog & Environm Engn, Ctr Environm & Geog Sci, West Point, NY 10996 USA. [Usery, E. L.] US Geol Survey, Ctr Excellence Geospatial Informat Sci, Rolla, MO 65401 USA. RP Madden, M (reprint author), Univ Georgia, Dept Geog, Ctr Remote Sensing & Mapping Sci, Athens, GA 30602 USA. EM Steven.Fleming@usma.edu; tombob@uga.edu; mmadden@uga.edu; usery@usgs.gov; rwelch@uga.edu FU National Geospatial-Intelligence Agency's University Research Initiative [NMA 201-01-1-2009] FX This study was conducted in support of Agreement NMA 201-01-1-2009, funded by the National Geospatial-Intelligence Agency's University Research Initiative. The authors wish to express their appreciation to Dr. Scott Loomer of the National Geospatial-Intelligence Agency (NGA) for his assistance throughout the project along with other NGA personnel: Rear Admiral Christian Andreasen, Brian Carson, Karen Gray and Dr. Richard Brand. The cooperation of numerous Marine Corps and civilian personnel at Camp Lejeune permitted field checks to be completed and database entries to be verified. We would particularly like to thank Master Sergeant Russell Dominessy, I.t. Colonel C. Reid Nichols and Ms. Frances Railey. Bathymetric and coastal data lists for the onslow Beach area were provided by the Naval Oceanographic Office with many valuable suggestions provided by Timothy Cox and other Naval Oceanographic Office personnel. Finally, we gratefully acknowledge the University of Georgia research assistants and staff at Center for Remote Sensing and Mapping Science: Jinmu Choi, Yanfen Le, Yangrong Ling, Thomas Litts and Virginia Vickery. NR 31 TC 4 Z9 5 U1 3 U2 39 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-2716 J9 ISPRS J PHOTOGRAMM JI ISPRS-J. Photogramm. Remote Sens. PD MAR PY 2009 VL 64 IS 2 BP 213 EP 222 DI 10.1016/j.isprsjprs.2008.10.004 PG 10 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA 425WN UT WOS:000264668600009 ER PT J AU Collen, J Mount, G Pollock, P Shrout, J Malafronte, P Vangeertruyden, P Oglesby, R AF Collen, Jacob Mount, George Pollock, Patrick Shrout, Joseph Malafronte, Patrick Vangeertruyden, Peter Oglesby, Robert TI Giant Cell Tumor of the Tendon Sheath SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY LA English DT Article ID LESIONS; HAND AB Giant cell tumor of the tendon sheath is a benign lesion of unclear etiology. It has characteristics that are consistent with chronic inflammation and neoplasm(1) and is considered the most common true neoplasm of the hand(2) and second most common tumor of the hand (after ganglia).(1) The exact tissue of origin is unknown,(3) but the lesion is thought to represent extra-articular extension of pigmented villonodular synovitis.(2) Cases of giant cell tumors in the fingers of patients with rheumatoid arthritis have been reported and may be coincidental.(4) Giant cell tumor of the tendon sheath are slow growing, persistent, and typically larger than rheumatoid tenosynovitis.(4) C1 [Collen, Jacob; Mount, George; Oglesby, Robert] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Pollock, Patrick; Shrout, Joseph] Walter Reed Army Med Ctr, Dept Orthoped, Hand Surg Serv, Washington, DC 20307 USA. [Malafronte, Patrick] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Vangeertruyden, Peter] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Collen, J (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM jcollen2002@hotmail.com NR 6 TC 2 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-1608 J9 JCR-J CLIN RHEUMATOL JI JCR-J. Clin. Rheumatol. PD MAR PY 2009 VL 15 IS 2 BP 85 EP 87 DI 10.1097/RHU.0b013e31818aa87a PG 3 WC Rheumatology SC Rheumatology GA 419KW UT WOS:000264219400011 PM 19265354 ER PT J AU Sadeck, JE Lee, CK AF Sadeck, James E. Lee, Calvin K. TI Continuous Disreefing Method for Parachute Opening SO JOURNAL OF AIRCRAFT LA English DT Article; Proceedings Paper CT AIAA Aerodynamics Decelerator Systems Technology Conference CY MAY 21-24, 2008 CL Williamsburg, VA SP Amer Inst Aeronaut & Astronaut AB Although round parachutes have been used for airdrop for over 60 years, damage to canopy fabric and suspension lines still occurs during parachute opening due to the rapid canopy opening and the associated high opening force. Continuous disreefing of round parachutes to slow down the opening and decrease the peak opening force has been discussed in the literature, but no viable continuous disreefing method has ever been developed. In this paper, we present a practical, effective, and low-cost continuous disreefing method that does not use any external electrical or power source, only the opening force and the weight of the payload. The method was successfully demonstrated in a full-scale test from an aircraft using a 10.7-m (35-ft) diameter round parachute. The kinetic energy of the payload at parachute deployment of that test was 11 times higher than that of the standard deployment that the parachute is designed for. In spite of the severe deployment condition, no damage to the parachute was observed after ground impact. C1 [Sadeck, James E.; Lee, Calvin K.] USA, Natick Soldier Res Dev & Engn Ctr, Warfighter Protect & Aerial Delivery Directorate, Natick, MA 01760 USA. RP Sadeck, JE (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, Warfighter Protect & Aerial Delivery Directorate, 15 Kansas St, Natick, MA 01760 USA. NR 9 TC 1 Z9 2 U1 0 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD MAR-APR PY 2009 VL 46 IS 2 BP 501 EP 504 DI 10.2514/1.37444 PG 4 WC Engineering, Aerospace SC Engineering GA 428OR UT WOS:000264858800013 ER PT J AU Ballato, J Hawkins, T Foy, P Kokuoz, B Stolen, R McMillen, C Daw, M Su, Z Tritt, TM Dubinskii, M Zhang, J Sanamyan, T Matthewson, MJ AF Ballato, J. Hawkins, T. Foy, P. Kokuoz, B. Stolen, R. McMillen, C. Daw, M. Su, Z. Tritt, T. M. Dubinskii, M. Zhang, J. Sanamyan, T. Matthewson, M. J. TI On the fabrication of all-glass optical fibers from crystals SO JOURNAL OF APPLIED PHYSICS LA English DT Article DE amorphisation; doping profiles; erbium; optical fibre cladding; optical fibre fabrication; optical fibre losses; silicon compounds; thermal conductivity; X-ray diffraction; yttrium compounds ID CR-DOPED FIBERS; AMPLIFIER; EMISSION; LASER AB The highly nonequilibrium conditions under which optical fibers conventionally are drawn afford considerable, yet underappreciated, opportunities to realize fibers comprised of novel materials or materials that themselves cannot be directly fabricated into fiber form using commercial scalable methods. Presented here is an in-depth analysis of the physical, compositional, and selected optical properties of silica-clad erbium-doped yttrium aluminosilicate glass optical fibers derived from undoped, 0.25, and 50 wt % Er(3+)-doped yttrium aluminum garnet (YAG) crystals. The YAG-derived fibers were found to be noncrystalline as evidenced by x-ray diffraction and corroborated by spectroscopic measurements. Elemental analysis across the core/clad interface strongly suggests that diffusion plays a large role in this amorphization. Despite the noncrystalline nature of the fibers, they do exhibit acceptable low losses (similar to 0.15-0.2 dB/m) for many applications, broad-band emissions in the near-infrared, and enhanced thermal conductivity along their length while maintaining equivalent mechanical strength with respect to conventional silica optical fibers. Further, considerably higher rare-earth doping levels are realized than can be achieved by conventional solution or vapor-phase doping schemes. A discussion of opportunities for such approaches to nontraditional fiber materials is presented. C1 [Ballato, J.; Hawkins, T.; Foy, P.; Kokuoz, B.; Stolen, R.; McMillen, C.; Daw, M.; Su, Z.; Tritt, T. M.] Clemson Univ, Sch Mat Sci & Engn, COMSET, Clemson, SC 29634 USA. [McMillen, C.] Clemson Univ, Dept Chem, Clemson, SC 29634 USA. [Daw, M.; Su, Z.; Tritt, T. M.] Clemson Univ, Dept Phys & Astron, Clemson, SC 29634 USA. [Dubinskii, M.; Zhang, J.; Sanamyan, T.] USA, Res Lab, AMSRD ARL SE EO, Adelphi, MD 20783 USA. [Matthewson, M. J.] Rutgers State Univ, Dept Mat Sci & Engn, Piscataway, NJ 08854 USA. RP Ballato, J (reprint author), Clemson Univ, Sch Mat Sci & Engn, COMSET, Clemson, SC 29634 USA. EM jballat@clemson.edu RI Matthewson, John /H-6198-2012 OI Matthewson, John /0000-0002-8173-414X FU Joint Technology Office (JTO); USARO [W911NF-05-10517]; USAFOSR [FA9550-07-1-0566] FX This work was supported in part by the Joint Technology Office (JTO) through their High Energy Laser Multidisciplinary Research Initiative (HEL-MRI) programs at Clemson University: "High Power Fiber Lasers" under an ARL supplement to USARO under Contract No. W911NF-05-10517 and "Eye-Safe Polycrystalline Lasers" under USAFOSR under Contract No. FA9550-07-1-0566. Additionally, the authors wish to thank Northrop Grumman- Synoptics (Charlotte, NC) for providing at no cost the undoped and doped YAG samples, Dr. Bob Rice of Northrop Grumman Space Technology (Redondo Beach, CA) for insightful comments, and Dr. Larry McCandlish of Ceramare (Piscataway, NJ) for core- drilling the YAG samples. NR 14 TC 43 Z9 43 U1 0 U2 28 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 1 PY 2009 VL 105 IS 5 AR 053110 DI 10.1063/1.3080135 PG 9 WC Physics, Applied SC Physics GA 418NZ UT WOS:000264156300011 ER PT J AU Metcalfe, GD Readinger, ED Shen, H Woodward, NT Dierolf, V Wraback, M AF Metcalfe, Grace D. Readinger, Eric D. Shen, Hongen Woodward, Nathaniel T. Dierolf, Volkmar Wraback, Michael TI Crystal-field split levels of Nd3+ ions in GaN measured by luminescence spectroscopy SO JOURNAL OF APPLIED PHYSICS LA English DT Article DE crystal field interactions; energy gap; excited states; gallium compounds; III-V semiconductors; molecular beam epitaxial growth; neodymium; photoluminescence; plasma materials processing; semiconductor doping; semiconductor thin films; Stark effect; wide band gap semiconductors ID DOPED GAN; ROOM-TEMPERATURE; ER; ELECTROLUMINESCENCE; PHOTOLUMINESCENCE; EMISSION AB We present the Stark energy sublevels of Nd3+ ions in GaN grown by plasma-assisted molecular beam epitaxy as determined by luminescence spectra. We correlate the photoluminescence spectra with transitions from the F-4(3/2) excited state to the I-4(9/2), I-4(11/2), and I-4(13/2) multiplets of the Nd3+ ion for above and below bandgap excitation, with the strongest emission occurring at 1.12 eV (1106 nm). We determine a splitting of the F-4(3/2) excited state to be 4.1 meV. From photoluminescence excitation spectra, we also identify the Stark sublevels of the upper states F-4(5/2), H-2(9/2), F-4(7/2), S-4(3/2), (2)G(7/2), and (4)G(5/2). Photoluminescence excitation spectra reveal an optimal excitation energy of 1.48 eV (836 nm). Site-selective spectroscopy studies using combined excitation-emission spectroscopy with confocal microscopy indicate enhanced substantial doping at the Ga site. C1 [Metcalfe, Grace D.; Readinger, Eric D.; Shen, Hongen; Wraback, Michael] USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, Adelphi, MD 20783 USA. [Woodward, Nathaniel T.; Dierolf, Volkmar] Lehigh Univ, Dept Phys, Bethlehem, PA 18015 USA. RP Metcalfe, GD (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM grace.metcalfe@us.army.mil NR 17 TC 19 Z9 19 U1 1 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 1 PY 2009 VL 105 IS 5 AR 053101 DI 10.1063/1.3082500 PG 5 WC Physics, Applied SC Physics GA 418NZ UT WOS:000264156300002 ER PT J AU Potter, BK Adams, SC Qadir, R Pitcher, JD Temple, HT AF Potter, Benjamin K. Adams, Sheila C. Qadir, Rabah Pitcher, J. David Temple, H. Thomas TI Fungating Soft-Tissue Sarcomas Treatment Implications and Prognostic Importance of Malignant Ulceration SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID ADJUVANT CHEMOTHERAPY; RADIATION-THERAPY; CHRONIC OSTEOMYELITIS; RANDOMIZED-TRIAL; LOCAL RECURRENCE; LOWER-EXTREMITY; SURVIVAL; SURGERY; SYSTEM; LIMB AB Background: Several variables have been reported as being prognostic with regard to the outcomes of soft-tissue sarcomas. Although the tumors are subjectively ominous, no prior study has been performed to evaluate the treatment or prognosis of fungating soft-tissue sarcomas. Methods: We performed a retrospective review of all soft-tissue sarcomas treated at our institution between 1989 and 2004 that had been followed for a minimum of two years or until the death of the patient. Our study group consisted of twenty-four patients with a primary high-grade fungating tumor, and our control group consisted of 146 consecutive patients with a primary high-grade non-fungating tumor. The study cohorts were compared with regard to disease presentation, treatment, and oncologic outcomes. Results: There were no significant differences in tumor size, tumor depth, or histopathologic diagnoses between the cohorts, although the patients with a fungating tumor tended to be older (mean, sixty-five years compared with fifty-five years in the control group; p = 0.004) and have shorter postoperative follow-up (mean, thirty-eight months compared with sixty-five months in the control group; p = 0.03). The proportion of patients presenting with metastases was significantly greater in the group with a fungating tumor (33% compared with 9% in the control group; p = 0.003). Significantly more patients with a fungating tumor underwent amputation (35% compared with 12% in the control group; p = 0.01), while a greater proportion of control patients received radiation therapy (68% compared with 39% in the group with a fungating tumor; p = 0.02). There was no difference in the proportions of patients receiving chemotherapy or in the local recurrence rates between the two cohorts. The Kaplan-Meier five-year overall survival estimates were 20% in the group with a fungating tumor compared with 63% (p < 0.0001) in the control group. The Kaplan-Meier five-year disease-specific survival estimates for patients presenting with localized disease was 58% in the group with a fungating tumor and 74% in the control group (p = 0.05). Multivariate analysis demonstrated that disease stage, fungation, and a tumor size of >= 10 cm were significant independent negative prognostic factors for disease-specific survival. Conclusions: Malignant tumor ulceration is an independent predictor of a poor prognosis for patients with a high-grade soft-tissue sarcoma. Despite the discouraging overall prognosis, aggressive multidisciplinary treatment can lead to long-term survival in an important subgroup of patients with fungating lesions. C1 [Potter, Benjamin K.; Adams, Sheila C.; Qadir, Rabah; Pitcher, J. David; Temple, H. Thomas] Univ Miami, Miller Sch Med, Dept Orthopaed, Miami, FL 33136 USA. RP Potter, BK (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW,Bldg 2A,Room 205, Washington, DC 20307 USA. EM benjamin.potter@amedd.army.mil OI Potter, MD, Benjamin K./0000-0002-8771-0317 NR 39 TC 1 Z9 1 U1 0 U2 0 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD MAR PY 2009 VL 91A IS 3 BP 567 EP 574 DI 10.2106/JBJS.H.00071 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 416CA UT WOS:000263981600008 PM 19255216 ER PT J AU Mack, AW Freedman, BA Shawen, SB Gajewski, DA Kalasinsky, VF Lewin-Smith, MR AF Mack, Andrew W. Freedman, Brett A. Shawen, Scott B. Gajewski, Donald A. Kalasinsky, Victor F. Lewin-Smith, Michael R. TI Wound Complications Following the Use of FiberWire in Lower-Extremity Traumatic Amputations A Case Series SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID SILICONE BREAST IMPLANTS; CAPSULAR CONTRACTURE; AUGMENTATION; SHOULDER; FIBROSIS; REPAIR C1 [Mack, Andrew W.; Freedman, Brett A.; Shawen, Scott B.; Gajewski, Donald A.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC 20307 USA. Armed Forces Inst Pathol, Dept Environm & Toxicol Pathol, Washington, DC 20306 USA. RP Mack, AW (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Orthopaed Surg Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM andrew.mack@amedd.army.mil NR 16 TC 8 Z9 8 U1 0 U2 0 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD MAR PY 2009 VL 91A IS 3 BP 680 EP 685 DI 10.2106/JBJS.H.00110 PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 416CA UT WOS:000263981600022 PM 19255230 ER PT J AU Marshall, DA Walizer, EM Vernalis, MN AF Marshall, Debra A. Walizer, Elaine M. Vernalis, Marina N. TI Achievement of Heart Health Characteristics Through Participation in an Intensive Lifestyle Change Program (Coronary Artery Disease Reversal Study) SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION LA English DT Article DE coronary disease; lifestyle; prevention; risk factors ID ATHEROSCLEROTIC VASCULAR-DISEASE; CARDIOVASCULAR RISK PROFILE; ALL-CAUSE MORTALITY; QUALITY-OF-LIFE; PRIMARY PREVENTION; SERUM-LIPIDS; MIDDLE-AGE; EXERCISE; WOMEN; MEN AB PURPOSE: Lifestyle habits and cardiovascular disease (CVD) risk factors are closely linked. Unfortunately, few individuals meet the goals for cardiovascular health that are recommended in public health initiatives. The purpose of this Study was to determine the effect of an intensive lifestyle intervention program on the achievement of a group of recognized heart health characteristics as well as on the reduction of individual CVD risk factors. METHODS: Of 200 military healthcare beneficiaries with coronary artery disease or CVD risk factors (mean age = 61 years) who entered a 1-year, prospective, cohort, multicomponent lifestyle intervention study (lacto-ovo vegetarian diet, exercise, stress management, group support), 186 subjects enrolled and 144 participated for 1 year. RESULTS: At 3 months and 1 year compared with baseline, the proportion Of Subjects meeting 5 recognized heart health characteristics improved (P <.001): fiber intake >25 g/d (94% and 72% vs 35%); exercise >= 150 min/wk (79% and 58% vs 31 V; low-density lipoprotein cholesterol <100 mg/dL (75% and 63% vs 46%); body mass index <25 kg/m(2) (34% and 38% vs 23%); and blood pressure < 140/90 mm Hg (84% and 83% vs 69%). At 1 year, more subjects (72% vs 32% at baseline), especially those with intervention adherence above (94%) versus below (58%) the study population median (P <.0005), achieved 3 or more of these characteristics. CONCLUSION: An intensive lifestyle intervention promotes achievement of important heart health characteristics that, if maintained, may so stantially reduce CVD events. C1 [Walizer, Elaine M.] Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, Washington, DC 20012 USA. Henry M Jackson Fdn Advancement Mil Med, Rockville, MD USA. RP Walizer, EM (reprint author), Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, POB 59608, Washington, DC 20012 USA. EM elaine.walizer@amedd.army.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine (Rockville, Maryland); US Army Medical Research and Materiel Command; Uniformed Services University of the Health Sciences; Department of Clinical Investigation at the Walter Reed Army Medical Center FX This work was supported by the Integrative Cardiac Health Project, a congressionally funded program of the Henry M. Jackson Foundation for the Advancement of Military Medicine (Rockville, Maryland), the US Army Medical Research and Materiel Command, the Uniformed Services University of the Health Sciences, and the Department of Clinical Investigation at the Walter Reed Army Medical Center. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the US government. NR 32 TC 7 Z9 8 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1932-7501 J9 J CARDIOPULM REHABIL JI J. Cardiopulm. Rehabil. Prev. PD MAR-APR PY 2009 VL 29 IS 2 BP 84 EP 94 PG 11 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 426QZ UT WOS:000264724100003 PM 19305232 ER PT J AU Mahlen, SD Clarridge, JE AF Mahlen, Steven D. Clarridge, Jill E., III TI Oral Abscess Caused by Campylobacter rectus: Case Report and Literature Review SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID WOLINELLA-RECTA; PERIODONTITIS LESIONS; GEN-NOV; GINGIVITIS; MICROBIOTA; INFECTIONS; GRACILIS; HEALTH; BONE AB Campylobacter rectus was isolated under routine anaerobic conditions (no additional hydrogen gas in the atmosphere) from an oral, nonperiodontal abscess from a patient with gastroesophageal adenocarcinoma. We report the first case of a palate abscess caused by C. rectus and review the literature and atmospheric requirements of this organism. C1 [Clarridge, Jill E., III] Vet Affairs Puget Sound Hlth Care Syst, Pathol & Lab Serv, Seattle, WA 98108 USA. [Mahlen, Steven D.; Clarridge, Jill E., III] Univ Washington, Dept Lab Med, USA, Seattle, WA 98195 USA. RP Clarridge, JE (reprint author), VA PSHCS, Pathol & Lab Serv 113, 1660 S Columbian Way, Seattle, WA 98108 USA. EM Jill.clarridge@va.gov NR 21 TC 10 Z9 10 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 2009 VL 47 IS 3 BP 848 EP 851 DI 10.1128/JCM.01590-08 PG 4 WC Microbiology SC Microbiology GA 413UU UT WOS:000263818800060 PM 19109480 ER PT J AU Vuyovich, CM Daly, SF Gagnon, JJ Weyrick, P Zaitsoff, M AF Vuyovich, Carrie M. Daly, Steven F. Gagnon, John J. Weyrick, Patricia Zaitsoff, Mark TI Monitoring River Ice Conditions Using Web-Based Cameras SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Article AB It is necessary to monitor river ice conditions at many northern locations where river ice can pose a risk. Web cameras have been used to monitor real-time ice conditions at hydropower plants, navigation reaches, or locations of ice-related flooding. This study demonstrates how Web cameras can also be used to investigate river ice processes. Hourly images taken over three winters at the confluence of the Allegheny River and Oil Creek in Oil City, Pa. were analyzed. Each image was manually reviewed and classified according to surface ice conditions: stationary ice cover, frazil ice, brash ice, or open lead formation in an ice cover. The percentage of the channel width in the image covered by each ice condition was recorded. The time series of ice data are presented along with the concurrent hydrological and meteorological data. The Web cameras were operational during the 2000-2001, 2001-2002, and 2002-2003 winter seasons and provided an effective and relatively inexpensive means of monitoring and analyzing the river ice conditions. C1 [Vuyovich, Carrie M.; Daly, Steven F.; Gagnon, John J.; Weyrick, Patricia] USA, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Zaitsoff, Mark] USA, Corps Engineers, Pittsburgh, PA 15222 USA. RP Vuyovich, CM (reprint author), USA, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM carrie.m.vuyovich@erdc.usace.army.mil NR 19 TC 6 Z9 7 U1 1 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD MAR PY 2009 VL 23 IS 1 BP 1 EP 17 DI 10.1061/(ASCE)0887-381X(2009)23:1(1) PG 17 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 407XL UT WOS:000263397500001 ER PT J AU Rao, MP Nilakantan, G Keefe, M Powers, BM Bogetti, TA AF Rao, M. P. Nilakantan, G. Keefe, M. Powers, B. M. Bogetti, T. A. TI Global/Local Modeling of Ballistic Impact onto Woven Fabrics SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article; Proceedings Paper CT 22nd Annual Technical Conference of the American-Society-for-Composites CY SEP 17-19, 2007 CL Seattle, WA SP Amer Soc Composites DE Ballistic impact; finite element modeling; projectile velocity; woven fabric; fabric material properties; fabric deformation ID ENERGY-ABSORPTION; FRICTION; COMPOSITES; ARMOR AB This study focuses on developing a global/local three-dimensional (3D) finite element model of a Kevlar KM2 (R) plain woven fabric applicable for examining ballistic impact from a spherical projectile. The impact event is modeled in LS-DYNA (R) including friction between the individual yarns as well as the projectile and fabric. When compared with the predictive capabilities of a 3D finite element model that includes the detailed undulating representation of the fabric architecture over the entire solution domain, the savings in computational effort afforded by the global/local model become especially attractive. The agreement with fully detailed 3D finite element simulations and ballistic experiments is also demonstrated. C1 [Rao, M. P.] Univ Florida, Dept Mech & Aerosp Engn, Ctr Adv Composites, Gainesville, FL 32608 USA. [Nilakantan, G.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Keefe, M.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Powers, B. M.; Bogetti, T. A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Rao, MP (reprint author), Univ Florida, Dept Mech & Aerosp Engn, Ctr Adv Composites, Gainesville, FL 32608 USA. EM mprao@ufl.edu RI Rao, Prabhakar/B-1415-2010; Nilakantan, Gaurav/B-8643-2012 OI Nilakantan, Gaurav/0000-0002-5375-9681 NR 21 TC 20 Z9 20 U1 0 U2 5 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD MAR PY 2009 VL 43 IS 5 BP 445 EP 467 DI 10.1177/0021998308097684 PG 23 WC Materials Science, Composites SC Materials Science GA 417OV UT WOS:000264086700004 ER PT J AU Lin, AE Yuzuriha, S McLean, S Mulliken, JB AF Lin, Angela E. Yuzuriha, Shunsuke McLean, Scott Mulliken, John B. TI Lesser Forms of Cleft Lip Associated With the Branchio-Oculo-Facial Syndrome SO JOURNAL OF CRANIOFACIAL SURGERY LA English DT Article DE Branchio-oculo-facial syndrome; cleft lip; cleft lip and palate; microform cleft lip; pseudocleft lip ID BILATERAL DERMAL THYMUS; MINI-MICROFORM; MUTATIONS; TISSUE; NECK AB Lesser forms of incomplete cleft lip (CL) have been called microfom, occult, forme fruste, and congenitally healed. The association of a minimal bilateral CL in branchio-oculo-facial syndrome (BOFS) is well described and commonly referred to as a "pseudocleft." We conducted a systematic analysis of CL types in BOFS, including a retrospective cross-sectional chart and photographic review with variable longitudinal follow-up of our patients and those described in the literature. We compared data on the type of CL and palate (CL/P) and craniofacial and extracranial anomalies in patients with BOFS and classified the lesser forms CL as either minor-form, microform, or mini-microform as defined by the extent of disruption at the vermilion-cutaneous junction. The study comprised 62 patients with BOFS (1 new and 61 in literature, 4 treated by J.B.M). Forty-four patients (71%) had CL only; 16 (26%) had CL/P; and 2 patients had neither CL nor isolated CP Thirty-five patients with CL had adequate information for analysis (defined as either seen by J.B.M., having a published photograph, or having a detailed description). The most common type was bilateral symmetrical, lesser form CL (n = 20): minor-form (n = 2), microform (n = 6), or mini-microform (n = 12). Among 17 asymmetrical forms, the left side was more severely affected side than the right (12 vs 5). Of 9 patients with CUP and adequate clinical description, 4 were bilaterally symmetrically complete. Other anomalies, in addition to the familiar cardinal features of BOFS, included facial nerve weakness (n = 6), chin dimple or cleft of the lower lip (n = 4), upper labial pits (n = 6), minor digital anomalies (n = 12), renal anomalies (n = 14), and ectopic thymus (n = 18). This analysis reaffirms the high frequency of CL or CL/P in BOFS and the rarity of isolated cleft palate and underscores that the term "pseudocleft" lip is incorrect. The more precise lesser form designations used in this study may prove useful for future clinical studies because the causative gene, TFAP2A, is known. Lesser forms of CL may be the most subtle expression of BOFS and assist in identifying patients. Unlike major forms of CL/P, either, syndromic or non syndromic, lesser forms suggest that the developmental insult occurs later in labial formation when fusion of the medial nasal process and maxillary process is nearly complete. The deficient vermilion-mucosa and hypoplastic orbicularis oris may be the result of incomplete or deficient mesodermal penetration of the ectodermal envelope. Another possible pathogenic explanation is that failure of labial closure occurs earlier than in a major cleft when the primitive cells of ectoderm and mesoderm retain the capacity to "heal" the defect. C1 [Lin, Angela E.] MassGen Hosp Children, Genet Unit, Boston, MA USA. [Yuzuriha, Shunsuke; Mulliken, John B.] Childrens Hosp, Dept Plast Surg, Boston, MA 02115 USA. [McLean, Scott] Brooke Army Med Ctr, Dept Pediat, Houston, TX USA. RP Lin, AE (reprint author), 185 Cambridge St,Suite 2222, Boston, MA 02114 USA. EM lin.angela@mgh.harvard.edu NR 32 TC 9 Z9 9 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1049-2275 J9 J CRANIOFAC SURG JI J. Craniofac. Surg. PD MAR PY 2009 VL 20 BP 608 EP 611 DI 10.1097/SCS.0b013e3181927fb6 PG 4 WC Surgery SC Surgery GA 424MM UT WOS:000264570800010 PM 19795528 ER PT J AU Grimm, JW Wells, JL AF Grimm, Jason W. Wells, Jeffrey L. TI ILLEGAL IMMIGRANTS IN THE EMERGENCY DEPARTMENT: AN ETHICAL DILEMMA FOR NURSES? SO JOURNAL OF EMERGENCY NURSING LA English DT Article ID CARE C1 [Grimm, Jason W.] USAF, Lackland AFB, TX USA. [Wells, Jeffrey L.] USA, Walter Reed Army Med Ctr, Washington, DC 20310 USA. RP Grimm, JW (reprint author), 13000 Vista Norte,Apt 1425, San Antonio, TX 78216 USA. EM jasonwgrimm@aol.com NR 8 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-1767 J9 J EMERG NURS JI J. Emerg. Nurs. PD MAR PY 2009 VL 35 IS 2 BP 127 EP 128 DI 10.1016/j.jen.2008.08.018 PG 2 WC Emergency Medicine; Nursing SC Emergency Medicine; Nursing GA 426TU UT WOS:000264731600013 PM 19285176 ER PT J AU Yamane, K Ogawa, K Yoshida, M Hayashi, H Nakamura, T Yamanaka, T Tamaki, T Hojoh, H Leung, KP Fukushima, H AF Yamane, Kazuyoshi Ogawa, Kan Yoshida, Masahiro Hayashi, Hiroyuki Nakamura, Toshio Yamanaka, Takeshi Tamaki, Toshio Hojoh, Hirokazu Leung, Kai-Poon Fukushima, Hisanori TI Identification and Characterization of Clinically Isolated Biofilm-forming Gram-positive Rods from Teeth Associated with Persistent Apical Periodontitis SO JOURNAL OF ENDODONTICS LA English DT Article DE Bacillus subtilis; biofilm; periapical periodontitis ID BACILLUS-SUBTILIS; CHEMICAL-CHARACTERIZATION; CAPNOCYTOPHAGA-OCHRACEA; ENDODONTIC INFECTIONS; PERIAPICAL PATHOSIS; ROOT CANALS; BACTERIA; EXOPOLYSACCHARIDE; POLYSACCHARIDE; MICROORGANISMS AB We isolated spore-forming gram-positive aerobic rods from three patients with persistent periapical periodontitis. These cells possessed unique phenotypic characteristics by exhibiting dense meshwork-like structures on their cell surfaces that could be found in a number of biofilm-forming bacteria. We identified these strains as Bacillus subtilis by the API system and 16S ribosomal RNA gene (rRNA) sequencing. Treatment of the meshwork-like structures with protease K and staining with calcofluor for polysaccharides indicated that these structures were polysaccharides in nature and could be essential for biofilm formation by these isolates. Our findings suggest that B. subtilis could form biofilms in periapical periodontitis lesions, and this might contribute to the resistance to treatment resulting in the development of persistent periapical periodontitis observed in these patients. The particular mechanisms for B. subtilis biofilms to develop periapical periodontitis are still unknown. Further studies are needed to clarify the role of biofilms in persistent infections. (J Endod 2009;35:347-352) C1 [Yamane, Kazuyoshi; Ogawa, Kan; Nakamura, Toshio; Yamanaka, Takeshi; Fukushima, Hisanori] Osaka Dent Univ, Dept Bacteriol, Hirakata, Osaka 5731121, Japan. [Yoshida, Masahiro; Hayashi, Hiroyuki] Osaka Dent Univ, Dept Endodont, Hirakata, Osaka 5731121, Japan. [Leung, Kai-Poon] Walter Reed Army Inst Res, Microbiol Branch, US Army Dent & Trauma Res Detachment, Great Lakes, IL USA. RP Yamane, K (reprint author), Osaka Dent Univ, Dept Bacteriol, 8-1 Kuzuhahanazono Cho, Hirakata, Osaka 5731121, Japan. EM yamane@cc.osaka-dent.ac.jp NR 33 TC 7 Z9 9 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAR PY 2009 VL 35 IS 3 BP 347 EP 352 DI 10.1016/j.joen.2008.11.032 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 427EF UT WOS:000264761900006 PM 19249593 ER PT J AU Roberts, S Vender, JR Causey, MS Roberts, JR Loushine, RJ Morris, WJ Looney, SW AF Roberts, Steven Vender, John R. Causey, Mark S. Roberts, Jefferson R. Loushine, Robert J. Morris, Walter J. Looney, Stephen W. TI The Impact of Dental Devices on Neurostimulators SO JOURNAL OF ENDODONTICS LA English DT Article DE Apex locator; electric pulp tester; electrocautery; neurostimulator ID STIMULATION AB Spinal cord stimulation has been a therapeutic option for chronic pain for over 40 years. The neurostimulator (NS) is a device consisting of three primary components: an electrode array configured either as a paddle or wire; an implantable pulse generator (IPG) consisting of a minicomputer, a transceiver/antenna, an electrical generator, and a battery; and insulated wiring connecting the electrode to the IPG. The electrode array can be implanted into the epidural space overlying the dorsal spinal cord or along a peripheral nerve. The device generates pulsed electrical signals that stimulate the underlying dorsal columns of the spinal cord resulting in the perception of paresthesia by the patient. When overlapped with painful areas, the paresthesia can help decrease the patient's level of pain. The increased applications and indications for this technology enhance the likelihood that the NS patient will be seen in the dental practice. Therefore, the purpose of this study was to investigate whether electromagnetic interference of the NS occurred during the operation of the apex locator, the electric pulp tester (EPT), or the electrocautery unit. An NS was implanted into the epidural space of a human cadaver. The dental devices were used intraorally, and the implant's circuitry was tested after each trial. Two apex locators, two EPTs, and one electrocautery unit were tested. Seventy trials were used by each dental device on each tissue. Using the exact binomial method of determining confidence intervals, the probability of damage to the NS by any of the devices was negligible. (J Endod 2009;35:422-425) C1 [Roberts, Steven] Med Coll Georgia, Dept Endodont, Sch Dent, Augusta, GA 30912 USA. [Vender, John R.] Med Coll Georgia, Dept Neurosurg, Sch Med, Augusta, GA 30912 USA. [Roberts, Jefferson R.] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC USA. [Morris, Walter J.] Med Coll Georgia, Sch Dent, Dept Prosthodont, Augusta, GA 30912 USA. [Looney, Stephen W.] Med Coll Georgia, Dept Biostat, Augusta, GA 30912 USA. RP Roberts, S (reprint author), Med Coll Georgia, Dept Endodont, Sch Dent, Augusta, GA 30912 USA. EM Sroberts@mail.mcg.edu NR 13 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAR PY 2009 VL 35 IS 3 BP 422 EP 425 DI 10.1016/j.joen.2008.12.005 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 427EF UT WOS:000264761900022 PM 19249609 ER PT J AU McGowan, CP Millspaugh, JJ Ryan, MR Kruse, CD Pavelka, G AF McGowan, Conor P. Millspaugh, Joshua J. Ryan, Mark R. Kruse, Casey D. Pavelka, Greg TI Estimating survival of precocial chicks during the prefledging period using a catch-curve analysis and count-based age-class data SO JOURNAL OF FIELD ORNITHOLOGY LA English DT Article DE catch-curve; Charadrius melodus; chick survival; count data; fecundity; Piping Plover; reproductive success ID REPRODUCTIVE SUCCESS; LOCAL-POPULATION; PLOVERS; GROWTH; MODEL AB Estimating reproductive success for birds with precocial young can be difficult because chicks leave nests soon after hatching and individuals or broods can be difficult to track. Researchers often turn to estimating survival during the prefledging period and, though effective, mark-recapture based approaches are not always feasible due to cost, time, and animal welfare concerns. Using a threatened population of Piping Plovers (Charadrius melodus) that breeds along the Missouri River, we present an approach for estimating chick survival during the prefledging period using long-term (1993-2005), count-based, age-class data. We used a modified catch-curve analysis, and data collected during three 5-day sampling periods near the middle of the breeding season. The approach has several ecological and statistical assumptions and our analyses were designed to minimize the probability of violating those assumptions. For example, limiting the sampling periods to only 5 days gave reasonable assurance that population size was stable during the sampling period. Annual daily survival estimates ranged from 0.825 (SD = 0.03) to 0.931 (0.02) depending on year and sampling period, with these estimates assuming constant survival during the prefledging period and no change in the age structure of the population. The average probability of survival to fledging ranged from 0.126 to 0.188. Our results are similar to other published estimates for this species in similar habitats. This method of estimating chick survival may be useful for a variety of precocial bird species when mark-recapture methods are not feasible and only count-based age class data are available. C1 [McGowan, Conor P.; Millspaugh, Joshua J.; Ryan, Mark R.] Univ Missouri, Sch Nat Resources, Dept Fisheries & Wildlife Sci, Columbia, MO 65211 USA. [Kruse, Casey D.; Pavelka, Greg] USA, Corps Engineers, Yankton, SD 57078 USA. RP McGowan, CP (reprint author), US Geol Survey, Patuxent Wildlife Res Ctr, 12100 Beech Forest Rd, Laurel, MD 20708 USA. EM cpmcg00@hotmail.com FU U. S. Fish and Wildlife Service; U. S. Geological Survey; Missouri Cooperative Fish; Wildlife Research Unit FX We thank the U. S. Fish and Wildlife Service, U. S. Geological Survey, and the Missouri Cooperative Fish and Wildlife Research Unit for financial and logistical support. We thank the U. S. Army Corps of Engineers for access to and use of the Piping Plover reproductive success database. We are grateful to M. A. Larson for assistance with data analysis and study design, and to M. A. Larson, J. S. Rikoon, F. R. Thompson III, S. J. Dinsmore, G. Ritchison, three anonymous reviewers, and the University of Missouri Avian Ecology Lab for reviewing this manuscript and helping us improve this study. NR 33 TC 11 Z9 11 U1 1 U2 12 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0273-8570 J9 J FIELD ORNITHOL JI J. Field Ornithol. PD MAR PY 2009 VL 80 IS 1 BP 79 EP 87 DI 10.1111/j.1557-9263.2009.00207.x PG 9 WC Ornithology SC Zoology GA 410TS UT WOS:000263601800009 ER PT J AU Waite, JG Jones, JM Turek, EJ Dunne, CP Wright, AO Yang, TCS Beckwitt, R Yousef, AE AF Waite, J. G. Jones, J. M. Turek, E. J. Dunne, C. P. Wright, A. O. Yang, T. C. S. Beckwitt, R. Yousef, A. E. TI Production of Shelf-Stable Ranch Dressing Using High-Pressure Processing SO JOURNAL OF FOOD SCIENCE LA English DT Article DE high-pressure processing; organic acid profile; ranch dressing; sensory analysis; spoilage ID SALAD DRESSINGS; PYROGLUTAMIC ACID; SPOILAGE; MICROORGANISMS; MAYONNAISE; FLAVOR; FOODS; FAT AB High-pressure processing (HPP) can reduce or eliminate microorganisms of concern in food without deteriorating product quality; however, quality benefits must justify the substantial capital investment for the utilization of this technology. HPP is particularly a beneficial preservation technology for products damaged by thermal treatments or when product quality could be improved by reformulation to raise pH or eliminate chemical preservatives. The primary objectives of this study were to determine the efficacy of HPP to protect premium ranch dressing (pH 4.4) from microbial spoilage and to assess changes in physical, chemical, and sensory attributes throughout the product's shelf life. In inoculated-packages studies, the efficacy of HPP was measured against ranch dressing spoilage organisms: Pediococcus acidilactici, Lactobacillus brevis, and Torulaspora delbrueckii. HPP treatment (600MPa, 3 min) decreased population of P. acidilactici, the most pressure-resistant spoilage organism tested, by >= 6.4 log CFU/g. During a shelf-life study of edible product, treating ranch dressing at 600 MPa for 5 min effectively prevented microbial spoilage throughout the storage period ( 26 wk at 4 and 26 degrees C). The pH and emulsion stability of ranch dressing were not adversely influenced by HPP. Extended storage of HPP product for 16 to 26 wk at 26 degrees C resulted in a decrease in consumer acceptance and significant changes in color and organic acid profile ( specifically, increased pyroglutamic acid). These changes were consistent with those expected during extended storage of commercially available products. HPP may be used to produce premium ranch dressing, with defined shelf-life and storage conditions, without significantly changing product attributes. C1 [Waite, J. G.; Jones, J. M.; Yousef, A. E.] Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA. [Turek, E. J.] Kraft Foods Global Inc, Glenview, IL 60025 USA. [Dunne, C. P.; Wright, A. O.; Yang, T. C. S.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Beckwitt, R.] Framingham State Coll, Dept Biol, Framingham, MA 01701 USA. RP Yousef, AE (reprint author), Ohio State Univ, Dept Food Sci & Technol, Parker Food Sci Bldg,2015 Fyffe Court, Columbus, OH 43210 USA. EM yousef.1@osu.edu RI Yousef, Ahmed/E-4358-2011; OI Beckwitt, Richard/0000-0003-4315-2808 FU U. S. Dept. of Agriculture [962099] FX This study was funded by the U. S. Dept. of Agriculture ( grant nr 962099). The authors would also like to thank Erin Horton, Shara Johnson, and Teresa Nguyen for assistance with preparation of dressing and preliminary data collection. The authors acknowledge the kind assistance of these researchers at Kraft Foods Global, Inc., D. Legan, A. Tay, and L. Young, for assistance in experimental planning and logistics and in conducting large-scale HPP of the samples; D. Dozier for conducting the viscosity measurements; and A. Mirarefi for the NMR/oil droplet size analyses. NR 34 TC 2 Z9 2 U1 2 U2 24 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD MAR PY 2009 VL 74 IS 2 BP M83 EP M93 DI 10.1111/j.1750-3841.2008.01064.x PG 11 WC Food Science & Technology SC Food Science & Technology GA 420EU UT WOS:000264272500042 PM 19323763 ER PT J AU Garcia, RD Valavanis, KP AF Garcia, R. D. Valavanis, K. P. TI The Implementation of an Autonomous Helicopter Testbed SO JOURNAL OF INTELLIGENT & ROBOTIC SYSTEMS LA English DT Article CT International Symposium on Unmanned Aerial Vehicles CY JUN 23-25, 2008 CL Orlando, FL DE Mobile robots; Helicopter control; Helicopter reliability; Modular computer systems ID SURVEILLANCE AB Miniature Unmanned Aerial Vehicles (UAVs) are currently being researched for a wide range of tasks, including search and rescue, surveillance, reconnaissance, traffic monitoring, fire detection, pipe and electrical line inspection, and border patrol to name only a few of the application domains. Although small/miniature UAVs, including both Vertical Takeoff and Landing (VTOL) vehicles and small helicopters, have shown great potential in both civilian and military domains, including research and development, integration, prototyping, and field testing, these unmanned systems/vehicles are limited to only a handful of laboratories. This lack of development is due to both the extensive time and cost required to design, integrate and test a fully operational prototype as well as the shortcomings of published materials to fully describe how to design and build a "complete" and "operational" prototype system. This work attempts to overcome existing barriers and limitations by detailing the technical aspects of a small UAV helicopter designed specifically as a testbed vehicle. This design aims to provide a general framework that will not only allow researchers the ability to supplement the system with new technologies but will also allow researchers to add innovation to the vehicle itself. C1 [Garcia, R. D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Valavanis, K. P.] Univ Denver, Dept Elect & Comp Engn, Sch Engn & Comp Sci, Denver, CO 80208 USA. RP Garcia, RD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM duster3@gmail.com; kvalavan@du.edu NR 48 TC 13 Z9 14 U1 1 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-0296 J9 J INTELL ROBOT SYST JI J. Intell. Robot. Syst. PD MAR PY 2009 VL 54 IS 1-3 BP 423 EP 454 DI 10.1007/s10846-008-9273-y PG 32 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA 423GN UT WOS:000264484900023 ER PT J AU Brown, A Garcia, R AF Brown, Ainsmar Garcia, Richard TI Concepts and Validation of a Small-Scale Rotorcraft Proportional Integral Derivative (PID) Controller in a Unique Simulation Environment SO JOURNAL OF INTELLIGENT & ROBOTIC SYSTEMS LA English DT Article CT International Symposium on Unmanned Aerial Vehicles CY JUN 23-25, 2008 CL Orlando, FL DE Simulink; MATLAB; UAV; UAS; Simulation; X-Plane; PID AB At the current time, the U. S. Army Research Laboratory's (ARL's) Vehicle Technology Directorate is interested in expanding its Unmanned Vehicles Division to include rotary wing and micro-systems control. The intent is to research unmanned aircraft systems not only for reconnaissance missions but also for targeting and lethal attacks. This project documents ongoing work expanding ARL's program in research and simulation of autonomous control systems. A proportional integral derivative control algorithm was modeled in Simulink (Simulink is a trademark of The MathWorks) and communicates to a flight simulator modeling a physical radio-controlled helicopter. Waypoint navigation and flight envelope testing were then systematically evaluated to the final goal of a feasible autopilot design. Conclusions are made on how to perhaps make this environment more dynamic in the future. C1 [Brown, Ainsmar] USA, Res Lab, Vehicle Technol Directorate, Natl Inst Aerosp, Aberdeen Proving Ground, MD 21005 USA. [Garcia, Richard] USA, Res Lab, Vehicle Technol Directorate, Motile Robot Inc, Aberdeen Proving Ground, MD 21005 USA. RP Brown, A (reprint author), USA, Res Lab, Vehicle Technol Directorate, Natl Inst Aerosp, Aberdeen Proving Ground, MD 21005 USA. EM ainsmar.brown@nianet.org NR 7 TC 6 Z9 6 U1 1 U2 8 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-0296 J9 J INTELL ROBOT SYST JI J. Intell. Robot. Syst. PD MAR PY 2009 VL 54 IS 1-3 BP 511 EP 532 DI 10.1007/s10846-008-9277-7 PG 22 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA 423GN UT WOS:000264484900027 ER PT J AU Dehn, JC AF Dehn, John C. TI The Hamdan Case and the Application of a Municipal Offence The Common Law Origins of 'Murder in Violation of the Law of War' SO JOURNAL OF INTERNATIONAL CRIMINAL JUSTICE LA English DT Article AB This article examines the legal origins of 'murder in violation of the law of war', an offence defined in the US Military Commissions Act (MCA) and resorted to in the case against Salim Ahmed Hamdan. Hamdan was acquitted of conspiring to commit this offence based in part on a questionable legal instruction. The acquittal may have been proper under a correct view of the law. Nevertheless, the specific context in which this offence was alleged, combined with the judge's instruction, highlights key aspects of the US approach to the prosecution of unprivileged fighters for a 'law of war violation'. This approach, which is substantially represented by the US Supreme Court's judgment in Ex parte Quirin, has been criticized by International Humanitarian Law (IHL) scholars as an erroneous view of customary IHL. However, close analysis of the legal and historical context in which this approach developed reveals that 'murder in violation of the law of war' is a municipal US offence that represents an English common law implementation of the law of nations. This article explains why reading this offence to incorporate IHL war crimes, as Hamdan's judge did, is inappropriate in the context of the MCA and Hamdan's case. It then demonstrates that the authorities relied upon by the Quirin Court, the Lieber Code and a treatise by authoritative US military law commentator, William Winthrop, understood punishment for law of war violations to be permitted by the law of nations but imposed under municipal law. Thus, 'murder in violation of the law of war' is properly viewed as a municipal, common law offence punishing unprivileged fighters. In future studies the author will address the appropriateness of prescribing and enforcing this municipal offence in extraterritorial armed conflict. C1 USMA, West Point, NY USA. RP Dehn, JC (reprint author), USMA, West Point, NY USA. EM johncdehn@gmail.com NR 26 TC 2 Z9 2 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1478-1387 J9 J INT CRIM JUSTICE JI J. Int. Crim. Justice PD MAR PY 2009 VL 7 IS 1 BP 63 EP 82 DI 10.1093/jicj/mqp015 PG 20 WC Law SC Government & Law GA V17VM UT WOS:000207964700006 ER PT J AU Sanghadasa, M Ashley, PR Lindsay, GA Bramson, MD Tawney, J AF Sanghadasa, Mohan Ashley, Paul R. Lindsay, Geoffrey A. Bramson, Michael D. Tawney, Jesse TI Backscatter Compensation in IFOG Based Inertial Measurement Units With Polymer Phase Modulators SO JOURNAL OF LIGHTWAVE TECHNOLOGY LA English DT Article DE Electro-optic polymers; gyroscopes; integrated optics devices; polymer waveguides ID FABRICATION; CHROMOPHORE; COMPONENTS AB Precision guidance in navigation systems requires highly accurate, compact, and low cost inertial measurement units (IMUs). The key active guided-wave component of the IMU is the phase modulator. In our approach, electro-optic polymers have been utilized in fabricating low loss phase modulators with low half-wave drive voltage using advanced hybrid waveguide fabrication processes and novel optical integration techniques. However, the interference between the primary wave and the backscatter waves generated by the phase modulator and/or the interference between the two counter-propagating backscatter waves at the detector of the IMU has been a major source of error in this approach. A novel technique was introduced in assessing the error caused by backscatter and an offset waveguide design was developed to suppress the interference of backscatter light. The novel design not only preserved the miniaturization, but also improved the insertion loss with the use of a shorter waveguide. The gyro level tests performed with the backscatter compensated modulators showed about 5 times improvement of the average bias uncertainty over gyros integrated with a standard symmetric phase modulator. C1 [Sanghadasa, Mohan; Ashley, Paul R.] USA, Weap Sci Directorate, Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. [Lindsay, Geoffrey A.; Bramson, Michael D.] NAVAIR, Res Dept, China Lake, CA 93555 USA. [Tawney, Jesse] Charles Stark Draper Lab Inc, Cambridge, MA 02139 USA. RP Sanghadasa, M (reprint author), USA, Weap Sci Directorate, Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. EM Mohan.Sanghadasa@us.army.mil; Paul.Ashley@us.army.mil; Geoffrey.Lindsay@navy.mil; Michael.Bramson@navy.mil; jtawney@draper.com NR 18 TC 2 Z9 3 U1 3 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0733-8724 J9 J LIGHTWAVE TECHNOL JI J. Lightwave Technol. PD MAR-APR PY 2009 VL 27 IS 5-8 BP 806 EP 813 DI 10.1109/JLT.2008.928915 PG 8 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA 439HH UT WOS:000265617700037 ER PT J AU Nersisyan, SR Tabiryan, NV Steeves, DM Kimball, BR AF Nersisyan, S. R. Tabiryan, N. V. Steeves, D. M. Kimball, B. R. TI OPTICAL AXIS GRATINGS IN LIQUID CRYSTALS AND THEIR USE FOR POLARIZATION INSENSITIVE OPTICAL SWITCHING SO JOURNAL OF NONLINEAR OPTICAL PHYSICS & MATERIALS LA English DT Review DE Polarization gratings; liquid crystals; optical switching; polymers; azobenzene; diffractive optics; photoalignment ID FOURIER-TRANSFORM POLARIMETRY; HOLOGRAPHIC GRATINGS; ANISOTROPIC GRATINGS; HIGH-EFFICIENCY; AZO-DYE; PHOTOINDUCED ANISOTROPY; SUBWAVELENGTH GRATINGS; DIFFRACTION EFFICIENCY; RELIEF GRATINGS; POLYMER-FILMS AB The ability of optical axis gratings (OAGs) to fully transfer the energy of an unpolarized incident light beam into the +/- 1st diffraction orders is explored below for development of a polarization-independent optical system with nonlinear transmission. Diffractive properties of OAGs based on azo dye doped liquid crystals (azo LCs) are efficiently controlled with low power radiation. Switching from diffractive to transmissive states of the OAG takes place within 50 ms at 60 W/cm(2) power density level, while the diffractive state is restored within similar to 1 s in the absence of radiation. High contrast optical switching is demonstrated with violet as well as green laser beams. A photoswitchable OAG is paired with a light-insensitive OAG in diffraction compensation configuration to obtain an optical system switchable from high to low transmission state. The thinness of OAGs required for high contrast switching ensures high overall transmission of the system. Given also the spectrally and angularly broadband nature of OAG diffraction and the capability of azo LC material systems to respond both to cw as well as short laser pulses makes the optical system under discussion very promising for optical switching applications. Presentation of these results is preceded by an "opinionated" review of prior developments and demystifying of the fabrication technique of high efficiency large area OAGs. C1 [Nersisyan, S. R.; Tabiryan, N. V.] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. [Steeves, D. M.; Kimball, B. R.] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Tabiryan, NV (reprint author), Beam Engn Adv Measurements Co, 809 S Orlando Ave,Suite 1, Winter Pk, FL 32789 USA. EM nelson@beamco.com FU U. S. Army Natick Soldier RDE Center PAO [U09-105] FX This work was supported by the U. S. Army Natick Soldier RD&E Center. The authors are grateful to L. Hoke, U. Hrozhyk, S. Serak and B. Ya. Zeldovich for discussions. This document has been approved for public release. US Army Natick Soldier RD&E Center PAO # U09-105. NR 187 TC 45 Z9 46 U1 2 U2 23 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-8635 EI 1793-6624 J9 J NONLINEAR OPT PHYS JI J. Nonlinear Opt. Phys. Mater. PD MAR PY 2009 VL 18 IS 1 BP 1 EP 47 PG 47 WC Optics; Physics, Applied SC Optics; Physics GA 441XA UT WOS:000265802600001 ER PT J AU Cole, RE Horacek, T AF Cole, Renee E. Horacek, Tanya TI Applying PRECEDE-PROCEED to Develop an Intuitive Eating Nondieting Approach to Weight Management Pilot Program SO JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR LA English DT Article DE participatory planning; intuitive eating; nondieting; Stages of Change AB Objective: To describe the use of a consolidated version of the PRECEDE-PROCEED participatory program planning model to collaboratively design an intuitive eating program with Fort Drum military Spouses tailored to their readiness to reject the dieting mentality and make healthful lifestyle modifications. Design: A consolidated version of PPECEDE-PROCEED guided demographic, epidemiological, behavioral, organizational, and administrative diagnosis through survey research. Focus groups composed of planning/steering committee members diagnosed environmental, organizational, adimistrative. and policy considerations. Objectives were set For each phase to assist with program tailoring. Setting: Recruitment at Fort Drum Army Installation, NY, summer 2004. Participants: Ninety-one military health beneficiaries aged 20-65 years of age completed the pilot-tested survey packet. Phenomenon of Interest: The survey assessed quality Of life issues, Diet Mentality, Healthy Eating Index, and Intuitive Eating Stages of Change scores, and desired program mix. Analysis: Mean and mode of survey responses and scores. Results: A 10-week "My Body Kriows When" intuitive eating program was tailored to increase attendance, reduce barriers, and increase successful rejection of a dieting mentality. Conclusions and Implications: A coiisolidated vcrsiou of PRECEDE-PROCEED efficiently guided participatory planning to tailor this program. C1 [Cole, Renee E.] Brooke Army Med Ctr, Outpatient Nutr Clin, Ft Sam Houston, TX 78234 USA. [Horacek, Tanya] Syracuse Univ, Dietet Dept Nutr & Hosp Management, Syracuse, NY USA. RP Cole, RE (reprint author), Brooke Army Med Ctr, Outpatient Nutr Clin, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM renee.e.cole@amedd.army.mil RI Horacek, Tanya/D-6355-2013 NR 29 TC 10 Z9 12 U1 1 U2 17 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1499-4046 J9 J NUTR EDUC BEHAV JI J. Nutr. Educ. Behav. PD MAR-APR PY 2009 VL 41 IS 2 BP 120 EP 126 DI 10.1016/j.jneb.2008.03.006 PG 7 WC Education, Scientific Disciplines; Nutrition & Dietetics SC Education & Educational Research; Nutrition & Dietetics GA 425BN UT WOS:000264612100008 PM 19304257 ER PT J AU Mojica, EK Watts, BD Paul, JT Voss, ST Pottie, J AF Mojica, Elizabeth K. Watts, Bryan D. Paul, John T. Voss, Samuel T. Pottie, James TI FACTORS CONTRIBUTING TO BALD EAGLE ELECTROCUTIONS AND LINE COLLISIONS ON ABERDEEN PROVING GROUND, MARYLAND SO JOURNAL OF RAPTOR RESEARCH LA English DT Article DE Bald Eagle; Haliaeetus leucocephalus; Chesapeake Bay; collision; eagle concentration area; electrocution; electrical line; mortality ID CHESAPEAKE BAY C1 [Mojica, Elizabeth K.; Watts, Bryan D.] Coll William & Mary, Ctr Conservat Biol, Williamsburg, VA 23187 USA. [Paul, John T.; Pottie, James] USA, Directorate Safety Hlth & Environm, Aberdeen Proving Ground, MD 21010 USA. [Voss, Samuel T.] EA Engn Sci & Technol, Edgewood, MD 21040 USA. RP Mojica, EK (reprint author), Coll William & Mary, Ctr Conservat Biol, POB 8795, Williamsburg, VA 23187 USA. EM ekmojica@wm.edu RI Mojica, Elizabeth/G-1504-2012 OI Mojica, Elizabeth/0000-0001-6941-4840 FU U.S. Army FX This work was funded by the U.S. Army. We thank the many Army personnel and game wardens who documented carcasses. Three anonymous reviewers provided comments and suggestions that improved the manuscript. NR 19 TC 5 Z9 5 U1 1 U2 8 PU RAPTOR RESEARCH FOUNDATION INC PI HASTINGS PA 14377 117TH STREET SOUTH, HASTINGS, MN 55033 USA SN 0892-1016 J9 J RAPTOR RES JI J. Raptor Res. PD MAR PY 2009 VL 43 IS 1 BP 57 EP 61 DI 10.3356/JRR-07-60.1 PG 5 WC Ornithology SC Zoology GA 420MG UT WOS:000264293300007 ER PT J AU Gomez, R Murray, CK Hospenthal, DR Cancio, LC Renz, EM Holcomb, JB Wade, CE Wolf, SE AF Gomez, Ruben Murray, Clinton K. Hospenthal, Duane R. Cancio, Leopoldo C. Renz, Evan M. Holcomb, John B. Wade, Charles E. Wolf, Steven E. TI Causes of Mortality by Autopsy Findings of Combat Casualties and Civilian Patients Admitted to a Burn Unit SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID RENAL REPLACEMENT THERAPY; ACUTE KIDNEY INJURY; BETA-BLOCKER USE; DEPENDENT DIFFERENCES; IMPROVED OUTCOMES; SURVIVAL; INFECTION; FAILURE; CARE; COLONIZATION AB BACKGROUND: Approximately 5% of combat-related injuries include burns. Previous studies have shown similar mortality rates between military and civilian burn casualties; but causes of death were not detailed. STUDY DESIGN: We retrospectively reviewed autopsy reports of patients with burns treated at the US Army Institute of Surgical Research Burn Center from 2004 to 2007. RESULTS: Of 1,255 admissions, 100 (8%) died, with autopsies performed on 74 (36 burned during military operations). Causes of death included infection (61%); disorders of the pulmonary (55%), cardiac (36%), renal (27%), gastrointestinal (27%), and central nervous (11%) systems; and multiorgan dysfunction (15%). Patients burned as a result of military operations were younger men with more associated inhalation injuries, greater severity of injury, and longer time from injury to admission and to death. They died more frequently of infection (notably fungus, Pseudomonas, and Klebsiella) and gastrointestinal complications; and those not burned in military operations had greater numbers of cardiac and renal causes of death. CONCLUSION: Casualties of military operations are clinically different and die from different causes than patients not burned during military operations. The differences are likely reflective of a younger population, with greater severity of illness and longer times from injury to admission. Therapeutic interventions should focus on prevention of infection and gastrointestinal catastrophes in military burn casualties, which are similar to younger burn patients in the US, and minimizing cardiac complications in civilian burn casualties, who are typically older patients and possibly reflective of patients with more comorbidities. (J Am Coll Surg 2009;208:348-354. (C) 2009 by the American College of Surgeons) C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.; Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Gomez, Ruben; Cancio, Leopoldo C.; Renz, Evan M.; Holcomb, John B.; Wade, Charles E.; Wolf, Steven E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 40 TC 41 Z9 42 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD MAR PY 2009 VL 208 IS 3 BP 348 EP 354 DI 10.1016/j.jamcollsurg.2008.11.012 PG 7 WC Surgery SC Surgery GA 420AE UT WOS:000264260000004 PM 19317995 ER PT J AU Kim, HC Sames, WJ Chong, ST Lee, IY Lee, DK Kim, HD Rueda, LM Klein, TA AF Kim, Heung-Chul Sames, William J. Chong, Sung-Tae Lee, In-Yong Lee, Dong-Kyu Kim, Hyun-Doo Rueda, Leopoldo M. Klein, Terry A. TI OVERWINTERING OF ANOPHELES LINDESAYI JAPONICUS LARVAE IN THE REPUBLIC OF KOREA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Overwintering; Anopheles lindesayi japonicus; larvae; Korea; Aedes togoi ID CULICIDAE; DIPTERA AB Mosquito larval surveillance for environmental monitoring and pest-control purposes was conducted monthly at dredged soil-dumping areas during the construction of a new harbor in Yongcheon Bay, approximately 5 kin SE of Jinhae, on the SW side of Namsan (Mt. Nam) and across the bay from Su-do (Su Island) in Gyeongsangnam Province, Republic or Korea (ROK) from November 2007 through April 2008. During this study, mosquitoes collected as overwintering larvae were Aedes togoi in brackish rock pools along the seashore and Anopheles lindesayi japonicus along the vegetated margins of a slow-flowing drainage ditch and associated freshwater ground pools containing green algae. Overwintering An. lindesayi larvae also were collected along stream margins and stream pools of moderate- to fast-flowing mountain streams near Chungju (Chungeheongbuk Province) (October 2007 and March 2008) and Munsan (Gyeonggi Province) (September 2007 and April 2008). First and second instars were collected and identified in late September 2007 through February 2008. During March and April, collections were primarily 3rd and 4th instars, and by the end of April, pupae were collected. This is the first report of An. lindesayi japonicus overwintering as larvae in the ROK. C1 [Sames, William J.] Def Logist Agcy, Ft Belvoir, VA USA. [Lee, In-Yong] Yonsei Univ, Dept Environm Med Biol, Coll Med, Seoul 120752, South Korea. [Lee, Dong-Kyu; Kim, Hyun-Doo] Kosin Univ, Dept Hlth & Environm, Pusan 606701, South Korea. [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Div Entomol, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA. [Klein, Terry A.] USAMED DAC K, Dept Prevent Med, APO, AP 96205 USA. RP Klein, TA (reprint author), 65th Med Brigade,Unit 15281, APO, AP 96205 USA. EM terry.klein@amedd.army.mil FU Center for Health Promotion and Preventive Medicine; Global Emerging Infections Surveillance and Response System; National Center for Medical Intelligence; Ministry of Maritime Affairs and Fisheries in the Republic of Korea FX Disclaimer: The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of Army, the Department of Defense, or the US government. NR 20 TC 4 Z9 4 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 2009 VL 25 IS 1 BP 32 EP 37 DI 10.2987/08-5781.1 PG 6 WC Entomology SC Entomology GA 425UZ UT WOS:000264664300005 PM 19432066 ER PT J AU Abadie, JM AF Abadie, Jude M. TI Henry Bence Jones: The Father of Clinical Chemistry? SO LABMEDICINE LA English DT Biographical-Item C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Abadie, JM (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0007-5027 J9 LABMEDICINE JI Labmedicine PD MAR PY 2009 VL 40 IS 3 BP 181 EP 182 DI 10.1309/LMA7XI9FGWDJZ4OY PG 2 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 411ND UT WOS:000263655400010 ER PT J AU Pierce, JR Tuckow, AP Alemany, JA Rarick, KR Staab, JS Harman, EA Nindl, BC AF Pierce, Joseph R. Tuckow, Alexander P. Alemany, Joseph A. Rarick, Kevin R. Staab, Jeffery S. Harman, Everett A. Nindl, Bradley C. TI Effects of Acute and Chronic Exercise on Disulfide-Linked Growth Hormone Variants SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE SOMATOTROPIN; GLUTATHIONE REDUCTION; RECEPTOR DIMERIZATION; GH DIMERS ID HEAVY RESISTANCE EXERCISE; AEROBIC EXERCISE; RESPONSES; ISOFORMS; INTENSITY; RELEASE; WOMEN; MEN; GH; HETEROGENEITY AB PIERCE, J. R., A. P. TUCKOW, J. A. ALEMANY, K. R. RARICK, J, S. STAAB, E. A. HARMAN, and B. C. NINDL. Effects of Acute and Chronic Exercise on Disulfide-Linked Growth Hormone Variants. Hed. Sci. Sports Exerc., Vol. 41, No. 3, pp. 581 597, 2009. Purpose: To test the hypothesis that the appearance of disulfide-linked growth hormone (GH) aggregates (luring and after an acute resistance exercise test (ARET) in men could be influenced by chronic physical training. Methods: Fourteen men (28 +/- 1 yr) underwent two different 8-wk physical training programs designed to improve military performance. Before and after chronic training, Subjects performed an ARET (six sets of 10 repetition-maximum squat) and had venous blood drawn pre-, mid-, and post-ARET (0, 15, and 30 min postexercise). To determine whether GH molecules were disuffide-linked, serum samples were chemically reduced via glutathione (GSH). Scrum immunoreactive GH (IRGH) and immunofunctional GH (IFGH) concentrations were determined using two specific immunoassays, in nonreduced (-GSH) and reduced (+GSH) states. Data were analyzed using repeated-measures ANOVA. Results: No differences were observed in the GH responses of the two training programs; therefore, training group data were combined for analysis. GSH reduction increased the mean GH signal (-GSH: 1.4 +/- 0.3 mu g.L-1 vs +GSH: 1.7 +/- 0.3 mu g.L-1; P < 0.01) only when quantitying IRGH. Post hoc testing indicated that serum contained IRGH disulfide-linked GH aggregates at the mid, 0-, 15-, and 30-min posttime points of the ARET (P < 0.01), whereas GSH reduction did not affect IFGH concentrations. Chronic physical training had no effect on the ARET-induced GH response. Conclusion: Acute resistance exercise leads to the appearance of disulfide-linked IRGH aggregates, and this response does not appear to be affected by 8 wk of chronic physical training. The physiological significance of increased proportions of disulfide-linked GH aggregates postexercise remains uncertain; however, structural alterations in GH moieties after acute exercise may represent important regulatory steps in mediating GH biological activity at selected target tissues. C1 [Pierce, Joseph R.; Tuckow, Alexander P.; Alemany, Joseph A.; Rarick, Kevin R.; Staab, Jeffery S.; Harman, Everett A.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Nindl, BC (reprint author), 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM bradley.nindl@amedd.army.mil NR 34 TC 7 Z9 7 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAR PY 2009 VL 41 IS 3 BP 581 EP 587 DI 10.1249/MSS.0b013e31818c6d93 PG 7 WC Sport Sciences SC Sport Sciences GA 412VL UT WOS:000263752200012 PM 19204593 ER PT J AU Goodman, DA Kenefick, RW Cadarette, BS Cheuvront, SN AF Goodman, Daniel A. Kenefick, Robert W. Cadarette, Bruce S. Cheuvront, Samuel N. TI Influence of Sensor Ingestion Timing on Consistency of Temperature Measures SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE GASTROINTESTINAL MOTILITY; INTESTINAL TEMPERATURE; MEANINGFUL THRESHOLD OF ACCEPTANCE; TELEMETRY ID CORE TEMPERATURE; GASTROINTESTINAL TRANSIT; CIRCADIAN-RHYTHM; BODY-TEMPERATURE; TELEMETRY PILL; EXERCISE; VALIDITY; VALIDATION; AGREEMENT; MODERATE AB GOODMAN, D. A., R. W. KENEFICK, B. S. CADARETTE, and S. N. CHEUVRONT. Influence of Sensor Ingestion Timing on Consistency of Temperature Measure. Med, Sci. Sports Exerc., Vol. 41, No. 3, pp. 597-602, 2009. Purpose: The validity and the reliability of using intestinal temperature (T(int)) via ingestible temperature sensors (ITS) to measure core body temperature have been demonstrated. However, the effect of elapsed time between ITS ingestion and Tint measurement has not been thoroughly studied. Methods: Eight volunteers (six men and two women) swallowed ITS 5 h (ITS-5) and 29 h (ITS-29) before 4 h of varying intensity activity. T(int) was measured simultaneously from both ITS, and T(int) differences between the ITS-5 and the ITS-29 over the 4 h of activity were plotted and compared relative to a meaningful threshold of acceptance (+0.25 degrees C). The percentage of time in which the differences between paired ITS (ITS-5 vs ITS-29) were greater than or less than the threshold of acceptance was calculated. Results: Tint Values showed no systematic bias, were normally distributed, and ranged from 36.94 degrees C to 39.24 degrees C. The maximum T(int) difference between paired ITS was 0.83 degrees C with a minimum difference of 0.00 degrees C. The typical magnitude of the differences (SE of the estimate) was 0.24 degrees C, and these differences were uniform across the entire range of observed temperatures. Paired Tint measures fell outside of the threshold of acceptance 43.8% of the time during the 4 h of activity. Conclusions: The differences between ITS-5 and ITS-29 Were larger than the threshold of acceptance during a Substantial portion of the observed 4-h activity period. Ingesting an ITS more than 5 h before activity will not completely eliminate confounding factors but may improve accuracy and consistency of core body temperature. C1 [Kenefick, Robert W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, 15 Kansas St, Natick, MA 01760 USA. EM kenefick@us.army.mil NR 31 TC 20 Z9 20 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAR PY 2009 VL 41 IS 3 BP 597 EP 602 DI 10.1249/MSS.0b013e31818a0eef PG 6 WC Sport Sciences SC Sport Sciences GA 412VL UT WOS:000263752200014 PM 19204591 ER PT J AU Bandara, AB Poff-Reichow, SA Nikolich, M Hoover, DL Sriranganathan, N Schurig, GG Dobrean, V Boyle, SM AF Bandara, Aloka B. Poff-Reichow, Sherry A. Nikolich, Mikeljon Hoover, David L. Sriranganathan, Nammalwar Schurig, Gerhardt G. Dobrean, Victor Boyle, Stephen M. TI Simultaneous expression of homologous and heterologous antigens in rough, attenuated Brucella melitensis SO MICROBES AND INFECTION LA English DT Article DE Brucella; Anthrax; Protective antigen; O-antigen; Persistence; Protection ID BACILLUS-ANTHRACIS; PROTECTIVE ANTIGEN; IMMUNE-RESPONSES; ABORTUS; MICE; RB51; DELETION; PLASMID; CLONING; VECTOR AB The possibility of expressing a homologous antigen and a heterologous antigen simultaneously in an attenuated Brucella melitensis strain was investigated. The Brucella wboA gene encoding a mannosyltransferase involved in biosynthesis of lipopolysaccharide O-antigen, and the Bacillus anthracis pag gene encoding the protective antigen (PA) were cloned into plasmid pBBR4MCS. The resulting plasmid was introduced into O-antigen deficient B. melitensis strain WRRP1 to produce strain WRSPA. Strain WRSPA produced O-antigen and a series of PA products, induced protection in BALB/c mice against challenge with B. melitensis strain 16M, but failed to protect A/J mice against challenge with B. anthracis Sterne strain. (C) 2009 Elsevier Masson SAS. All rights reserved. C1 [Bandara, Aloka B.; Poff-Reichow, Sherry A.; Sriranganathan, Nammalwar; Schurig, Gerhardt G.; Dobrean, Victor; Boyle, Stephen M.] Virginia Polytech Inst & State Univ, Ctr Mol Med & Infect Dis, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24061 USA. [Nikolich, Mikeljon; Hoover, David L.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Bandara, AB (reprint author), Virginia Polytech Inst & State Univ, Ctr Mol Med & Infect Dis, Virginia Maryland Reg Coll Vet Med, Washington St, Blacksburg, VA 24061 USA. EM abandara@vt.edu RI Nikolich, Mikeljon/B-2868-2011 FU Department of Defense [DAMD17-01-2-0035] FX This project was funded by Department of Defense grant # DAMD17-01-2-0035. The authors would like to thank Dr. Terri Koehler for providing the pag gene, and Dr. Steve Leppla for the anti-PA serum. NR 20 TC 3 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1286-4579 J9 MICROBES INFECT JI Microbes Infect. PD MAR PY 2009 VL 11 IS 3 BP 424 EP 428 DI 10.1016/j.micinf.2009.01.003 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 436HA UT WOS:000265402100015 PM 19397881 ER PT J AU Ku, F AF Ku, Fansu TI FROM LAW MEMBER TO MILITARY JUDGE: THE CONTINUING EVOLUTION OF AN INDEPENDENT TRIAL JUDICIARY IN THE TWENTY-FIRST CENTURY SO MILITARY LAW REVIEW LA English DT Article ID J.-HODSON-LECTURE C1 [Ku, Fansu] USA, Washington, DC USA. RP Ku, F (reprint author), 101st Airborne Div Air Assault, Ft Campbell, KY USA. NR 30 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2009 VL 199 BP 49 EP 88 PG 40 WC Law SC Government & Law GA 437XU UT WOS:000265521000002 ER PT J AU Brown, WE AF Brown, William E. TI DUAL STATUS NATIONAL GUARD TECHNICIANS SHOULD BE BARRED FROM BRINGING CIVIL SUITS UNDER TITLE VII SO MILITARY LAW REVIEW LA English DT Article C1 USA, TJAGLCS, Charlottesville, VA USA. RP Brown, WE (reprint author), USA, TJAGLCS, Charlottesville, VA USA. NR 7 TC 0 Z9 0 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2009 VL 199 BP 89 EP 118 PG 30 WC Law SC Government & Law GA 437XU UT WOS:000265521000003 ER PT J AU Huffman, WB AF Huffman, Walter B. TI THE FOURTEENTH HUGH J. CLAUSEN LECTURE IN LEADERSHIP SO MILITARY LAW REVIEW LA English DT Article C1 [Huffman, Walter B.] USA, Washington, DC USA. [Huffman, Walter B.] Texas Tech Univ, Sch Law, Lubbock, TX 79409 USA. RP Huffman, WB (reprint author), USA, Washington, DC USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2009 VL 199 BP 119 EP 134 PG 16 WC Law SC Government & Law GA 437XU UT WOS:000265521000004 ER PT J AU McCarthy, KA AF McCarthy, Kevin A. TI THE DARK SIDE: THE INSIDE STORY OF HOW THE WAR ON TERROR TURNED INTO A WAR ON AMERICAN IDEALS SO MILITARY LAW REVIEW LA English DT Book Review C1 [McCarthy, Kevin A.] USA, Washington, DC 20310 USA. RP McCarthy, KA (reprint author), USA, Washington, DC 20310 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2009 VL 199 BP 144 EP 152 PG 9 WC Law SC Government & Law GA 437XU UT WOS:000265521000006 ER PT J AU Berlin, S AF Berlin, Steve TI PRIVATE SECTOR, PUBLIC WARS: CONTRACTORS IN COMBAT-AFGHANISTAN, IRAQ AND FUTURE CONFLICTS SO MILITARY LAW REVIEW LA English DT Book Review C1 [Berlin, Steve] USA, Washington, DC 20310 USA. RP Berlin, S (reprint author), USA, Washington, DC 20310 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2009 VL 199 BP 153 EP 161 PG 9 WC Law SC Government & Law GA 437XU UT WOS:000265521000007 ER PT J AU Kamimori, GH Beller, D Fein, HG Smallridge, RC AF Kamimori, G. H. Beller, D. Fein, H. G. Smallridge, R. C. TI Hormonal and Cardiovascular Response to Low-Intensity Exercise With Atropine Administration SO MILITARY MEDICINE LA English DT Article ID INDUCED GH SECRETION; BLOCKADE; CORTISOL; STRESS; MEN AB The hormonal and cardiovascular responses to atropine and low-intensity exercise were examined in 7 young men. Subjects completed 3 trials in a single blind crossover design. During the first trial (T1), subjects received 2.0 mg of atropine intramuscularly at rest. Subsequently in trial 2 (T2), subjects received a saline placebo before 90 minutes of intermittent exercise, and during trial 3 (T3), they received atropine before 90 min of intermittent exercise [3 x (25-minute cycle/5-minute rest) @ 40% VO(2) peak]. Venous blood samples and physiological data were collected before, during, and post exercise. Growth hormone (GH) was significantly increased in T2 but unchanged in T1 and T3. Cortisol (CORT) was unchanged in T1 and T2, but in T3 significantly increased (p < 0.05) from 45 to 90 minutes compared to T2. Plasma luteinizing hormone (LH) was unaffected in all trials. Plasma prolactin (PRO) significantly increased in T3 from 45 to 90 minutes in comparison to T2. Norepinephrine (NE) was unaffected in T1, but significantly increased in both T2 and T3 (5 to 90 minutes). NE in T3 was also significantly higher compared to T2 (30 to 90 minutes). The heart rate (HR) and rate pressure product (RPP) significantly increased in all trials (15 to 90 minutes) and T3 was significantly elevated in comparison to T2. The administration of atropine before 90 minutes of low-intensity exercise significantly increased cortisol, prolactin, and norepinephrine, decreased growth hormone, and significantly increased cardiovascular stress. C1 [Kamimori, G. H.; Beller, D.; Fein, H. G.; Smallridge, R. C.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Behav Biol, Washington, DC 20307 USA. RP Kamimori, GH (reprint author), Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Behav Biol, Washington, DC 20307 USA. FU Division of Neuropsychiatry, Walter Reed Army Institute of Research FX We acknowledge the assistance of the staff of the Division of Neuropsychiatry, Walter Reed Army Institute of Research for their assistance and support in the completion of this study and the preparation of this manuscript. We also thank all persons from the Department of Exercise Leisure and Sport at Kent State University who assisted with the preparation of this manuscript. Human volunteers participated after giving their free and informed written consent. This research was conducted in conformity with AR 70-25 and U.S. Army Medical Research and Development Command (USAMRDC) Reg 70-25 on the use of human volunteers in research and the "Guiding Principles for Research Involving Animals and Human Beings." NR 24 TC 0 Z9 0 U1 0 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2009 VL 174 IS 3 BP 253 EP 258 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 601KZ UT WOS:000278059400007 PM 19354088 ER PT J AU Smith, EJ AF Smith, Earl Justice TI Multiple Sclerosis Presenting With Erotomanic Delusions in the Context of "Don't Ask, Don't Tell" SO MILITARY MEDICINE LA English DT Article ID PSYCHOSIS AB A female patient presented with erotomanic delusions of other female soldiers sexually harassing her and plotting to sexually assault her. On MRI, the patient was found to have numerous periventricular foci of signal changes extending into the deep white matter of both hemispheres. The MRI findings, along with lumbar puncture findings of oligoclonal bands in the cerebral spinal fluid, were consistent with a diagnosis of multiple sclerosis. After treatment with aripiprazole acutely and interferon beta-la for several months, the patient experienced a decrease in her psychosis. The discussion of this case includes a brief overview of psychosis as a presenting symptom of multiple sclerosis, and also includes consideration of the patient's initial reluctance to seek treatment in light of the policy known colloquially as "don't ask, don't tell." C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Smith, EJ (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW,Bldg 6,Borden Pavil, Washington, DC 20307 USA. NR 10 TC 4 Z9 4 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2009 VL 174 IS 3 BP 297 EP 298 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 601KZ UT WOS:000278059400013 PM 19354094 ER PT J AU Sherman, EM Svec, RV AF Sherman, Eric M. Svec, Rita V. TI Barriers to Vitamin D Supplementation Among Military Physicians SO MILITARY MEDICINE LA English DT Article ID BREAST-FED INFANTS; NUTRITIONAL RICKETS; D-DEFICIENCY; HEALTH SYSTEM; SUN EXPOSURE; CHILDREN; CARE; 25-HYDROXYVITAMIN-D; PREVENTION; PERCEPTIONS AB Objective: We surveyed military pediatricians and family physicians about barriers to vitamin D supplementation. Methods: We obtained lists of uniformed members of the American Academy of Pediatrics (AAP) and American Academy of Family Practice (AAFP). Three hundred individuals were randomly selected from each group and surveyed about: (1) practice habits; (2) vitamin D use and barriers to supplementation; (3) demographic factors. Results: Pediatricians were 40% more likely to be aware of AAP recommendations about vitamin D (p < 0.001) and 40% more likely to prescribe vitamin D to exclusively breastfed infants (p < 0.001). The most common reason for not recommending vitamin D was the belief that breastfed infants received adequate sunlight. Conclusions: Most military pediatricians supplement breastfed infants with vitamin D. Military family physicians are less likely to supplement breastfed infants and are targets for educational interventions. Many physicians mistakenly believe that adequate sunlight exposure prevents vitamin D deficiency, another focus for future interventions. C1 [Sherman, Eric M.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Svec, Rita V.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. RP Sherman, EM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. FU Uniformed Services University Office of Research FX We thank Cara Olsen, a statistician at Uniformed Services University of the Health Sciences who assisted with experimental design and data analysis and who edited the manuscript. This work was funded by the Uniformed Services University Office of Research. NR 36 TC 4 Z9 5 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2009 VL 174 IS 3 BP 302 EP 307 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 601KZ UT WOS:000278059400015 PM 19354096 ER PT J AU Sit, MT Arroyo, R AF Sit, Michelle T. Arroyo, Ramon TI Common Rheumatic Diseases of the Middle East SO MILITARY MEDICINE LA English DT Article ID FAMILIAL MEDITERRANEAN FEVER; BEHCETS-DISEASE AB Objective: The objective of this article is to educate military physicians and providers about rare, endemic rheumatic diseases that may be encountered in deployments to the Middle East region, specifically Familial Mediterranean Fever (FMF), Behcet's disease (BD), and tumor necrosis factor-associated periodic syndrome (TRAPS). Methods: We found review articles using MDConsult and Ovid. Results: Suitable articles were employed to describe the characteristics of each disease. Conclusions: Although these diseases are considered rare, they can be endemic to current areas of deployment. Awareness of these conditions may prevent unnecessary and invasive treatment as well as make the clinician aware of possible disease complications. C1 [Sit, Michelle T.; Arroyo, Ramon] Brooke Army Med Ctr, San Antonio, TX 78234 USA. RP Sit, MT (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. NR 15 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2009 VL 174 IS 3 BP 311 EP 314 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 601KZ UT WOS:000278059400017 PM 19354098 ER PT J AU Greenwald, BND Rigg, JL AF Greenwald, Bria N. D. Rigg, John L. TI Neurorehabilitation in Traumatic Brain Injury: Does It Make a Difference? SO MOUNT SINAI JOURNAL OF MEDICINE LA English DT Article DE brain injury; evidence; rehabilitation ID REHABILITATION; ATTENTION; SEIZURES; CRITERIA AB Each year, 1.4 million people in the United States are seen in a hospital for a traumatic brain injury. Those with moderate-to-serve traumatic brain injury frequently go through a course of inpatient neurorehabilitation prior to discharge back into the community. A broad overview of neurorehabilitation is presented, including the standards for admission to inpatient rehabilitation and the members and roles of the neurorehabilitation team. Common medical complications that are managed after moderate-to-severe traumatic brain injury are reviewed. The spectrum of arousal issues is summarized. The evidence regarding neurorehabilitation is then reviewed. Future studies that are underway to better understand the utility of neurohabilitation are then discussed. Mt Sinai J Med 76:182-189, 2009(C) 2009 Mount Sinai School of Medicine C1 [Greenwald, Bria N. D.] Mt Sinai Sch Med, Dept Rehabil Med, New York, NY USA. [Rigg, John L.] SE Reg Med Command, Dwight D Eisenhower Army Med Ctr, Traumat Brain Injury Program, Ft Gordon, GA USA. RP Greenwald, BND (reprint author), Mt Sinai Sch Med, Dept Rehabil Med, New York, NY USA. EM brian.greenwald@mountsinai.org NR 22 TC 9 Z9 9 U1 2 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0027-2507 J9 MT SINAI J MED JI Mt. Sinai J. Med. PD MAR-APR PY 2009 VL 76 IS 2 BP 182 EP 189 DI 10.1002/msj.20103 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 427OE UT WOS:000264787800011 PM 19306378 ER PT J AU Proper, A Zhang, W Bartolucci, S Oberai, AA Koratkar, N AF Proper, A. Zhang, W. Bartolucci, S. Oberai, A. A. Koratkar, N. TI In-Situ Detection of Impact Damage in Composites Using Carbon Nanotube Sensor Networks SO NANOSCIENCE AND NANOTECHNOLOGY LETTERS LA English DT Article DE Nano-Composites; Nano-Sensors; Impact Damage Detection; Structural Health Monitoring AB Fiber-reinforced composites are favored in aerospace and automotive applications due to their enhanced strength-to-weight and stiffness-to-weight ratios. However, impact-induced internal damage following low velocity impact is a major concern preventing the more aggressive use of fiber-reinforced composites in high performance structural applications. Here we show that by infiltrating a multiwalled carbon nanotube network into the composite, it is possible to detect impact-induced internal damage by monitoring localized disruptions in the electrical conductivity of the nanotube network. Such a built-in array of non-intrusive nano-sensors could enable the early detection of impending failures in real time before they become catastrophic. C1 [Proper, A.; Zhang, W.; Oberai, A. A.; Koratkar, N.] Rensselaer Polytech Inst, Troy, NY 12180 USA. [Bartolucci, S.] USA, Benet Labs, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. RP Koratkar, N (reprint author), Rensselaer Polytech Inst, 110 8th St, Troy, NY 12180 USA. FU US government [W911W6-06-2-0008]; United States-Israel Binational Science Foundation (BSF), Jerusalem, Israel [2004400] FX This research is partially funded by the US government under agreement No. W911W6-06-2-0008. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Government. A. A. Oberai acknowledges the support of Grant No. 2004400 from the United States-Israel Binational Science Foundation (BSF), Jerusalem, Israel. NR 12 TC 10 Z9 10 U1 0 U2 13 PU AMER SCIENTIFIC PUBLISHERS PI STEVENSON RANCH PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA SN 1941-4900 J9 NANOSCI NANOTECH LET JI Nanosci. Nanotechnol. Lett. PD MAR PY 2009 VL 1 IS 1 BP 3 EP 7 DI 10.1166/nnl.2009.002 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA V18KZ UT WOS:000208005000002 ER PT J AU Genovese, RF Benton, BJ Johnson, CC Jakubowski, EM AF Genovese, Raymond F. Benton, Bernard J. Johnson, Christina C. Jakubowski, E. Michael TI Assessment of low level whole-body soman vapor exposure in rats SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Soman; GD; Nerve agent; Cognition; Memory; Performance ID SCHEDULE-CONTROLLED BEHAVIOR; RADIAL-ARM MAZE; SUBLETHAL INHALATION EXPOSURE; AFRICAN-GREEN MONKEYS; MASS-SPECTROMETRY; ORGANOPHOSPHORUS COMPOUNDS; CHOLINESTERASE ACTIVITY; NERVOUS-SYSTEM; GUINEA-PIG; AGED RATS AB We evaluated biochemical and behavioral effects of single, low-level exposures to the chemical warfare nerve agent soman (GD). Male Sprague-Dawley rats were trained on a variable-interval, 56-sec schedule of food reinforcement (VI56). The schedule specifies that a single lever press, following an average interval of 56 s, produces food reinforcement (i.e., a single food pellet). After training, rats received a single 60 min exposure to soman vapor at concentrations of 1.0-7.0 mg/m(3), or air control (n = 8 for each treatment condition). Blood was sampled before and after the exposure. Following exposures, performance on the VI56 was evaluated for approximately 11 weeks. Additionally, the acquisition and maintenance of a radial-arm maze (RAM) spatial memory task were evaluated in the same subjects during the same 11-week period. Soman exposures produced miosis in all subjects but were otherwise essentially asymptomatic. That is, no convulsions or major signs of toxicity were observed in any subjects, a result consistent with a low-level concentration. Soman exposures produced significant and concentration-dependent decreases in circulating acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity. Soman exposures also produced concentration-dependent levels of regenerated soman in plasma and red blood cell fractions that served to verify the systemic exposure and estimate the total body burden. Soman exposure did not disrupt performance on the VI56 schedule as responding was maintained at pre-exposure levels throughout the 11-week period in all treatment groups. All subjects acquired, and maintained, performance on the RAM task and no significant differences were observed as a result of soman exposure. That is, soman-exposed rats learned the RAM task at the same general rate and to the same general level of accuracy as air-control rats. No delayed effects from exposures were observed. These results demonstrate that, in rats, single exposures to soman vapors at levels that produce substantial AChE and BChE inhibition, but below those producing convulsions and other severe clinical signs of toxicity, may not produce observable effects on the performance of a previously learned task or the acquisition of a new task. Published by Elsevier Inc. C1 [Genovese, Raymond F.; Johnson, Christina C.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Benton, Bernard J.; Jakubowski, E. Michael] USA, Edgewood Chem Biol Ctr, Operat Team, Aberdeen Proving Ground, MD USA. [Benton, Bernard J.; Jakubowski, E. Michael] USA, Edgewood Chem Biol Ctr, Analyt Toxicol Team, Aberdeen Proving Ground, MD USA. RP Genovese, RF (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM Raymond.Genovese@US.ARMY.MIL NR 56 TC 4 Z9 4 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAR-APR PY 2009 VL 31 IS 2 BP 110 EP 118 DI 10.1016/j.ntt.2008.10.003 PG 9 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA 435MM UT WOS:000265348000007 PM 19026741 ER PT J AU Smith, JC Henderson, DL Ortega, A DeVoe, J AF Smith, J. Cole Henderson, Dale L. Ortega, Alfonso DeVoe, Jason TI A parameter optimization heuristic for a temperature estimation model SO OPTIMIZATION AND ENGINEERING LA English DT Article DE Heuristic; Nonconvex optimization; Parameter estimation; Compact thermal models ID ELECTRONIC SYSTEMS; PACKAGE AB We present a heuristic technique for solving a parameter estimation problem that arises in modeling the thermal behavior of electronic chip packages. Compact Thermal Models (CTMs) are network models of steady state thermal behavior, which show promise in augmenting the use of more detailed and computationally expensive models. The CTM parameter optimization problem that we examine is a nonconvex optimization problem in which we seek a set of CTM parameters that best predicts, under general conditions, the thermal response of a particular chip package geometry that has been tested under a small number of conditions. We begin by developing a nonlinear programming formulation for this parameter optimization problem, and then develop an algorithm that uses special characteristics of the optimization problem to quickly generate heuristic solutions. Our algorithm descends along a series of solutions to one-dimensional nonconvex optimization problems, obtaining a locally optimal set of model parameters at modest computational cost. Finally, we provide some experimental results and recommendations for extending this research. C1 [Smith, J. Cole] Univ Florida, Dept Ind & Syst Engn, Gainesville, FL 32611 USA. [Henderson, Dale L.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Ortega, Alfonso] Villanova Univ, Dept Mech Engn, Villanova, PA 19085 USA. [DeVoe, Jason] ASE Technol, Phoenix, AZ 85021 USA. RP Smith, JC (reprint author), Univ Florida, Dept Ind & Syst Engn, 303 Weil Hall, Gainesville, FL 32611 USA. EM cole@ise.ufl.edu NR 24 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1389-4420 J9 OPTIM ENG JI Optim. Eng. PD MAR PY 2009 VL 10 IS 1 BP 19 EP 42 DI 10.1007/s11081-008-9039-1 PG 24 WC Engineering, Multidisciplinary; Operations Research & Management Science; Mathematics, Interdisciplinary Applications SC Engineering; Operations Research & Management Science; Mathematics GA 407TY UT WOS:000263388400002 ER PT J AU Glinka, YD Everitt, HO Lee, DS Steckl, AJ AF Glinka, Y. D. Everitt, H. O. Lee, D. S. Steckl, A. J. TI Effect of Tm3+-induced defects on the photoexcitation energy relaxation in Tm-doped AlxGa1-xN SO PHYSICAL REVIEW B LA English DT Article DE aluminium compounds; gallium compounds; III-V semiconductors; photoexcitation; photoluminescence; thulium; wide band gap semiconductors ID RARE-EARTH IONS; EMISSION; GAN AB We provide evidence that the Tm3+-induced defects in Tm-doped AlxGa1-xN hosts play a major role in the nonradiative transfer of the excitation energy from the I-1(6) state to the D-1(2) state of Tm3+ ions from which the most efficient photoluminescence (PL) transition (465 nm) occurs. Once the concentration of the Tm3+-induced defects decreases with increasing x, the PL transitions starting from the I-1(6) state (298, 357, 395, 530, and 785 nm) may be significantly enhanced. It is shown that the indirect excitation of the I-1(6) state results from the Auger-type energy transfer due to the nonradiative band-to-band recombinations in the AlxGa1-xN host of a given x. In contrast, the PL transitions starting from the (1)G(4) level (479 and 807 nm) can be excited through either an indirect or a direct regime. In both cases the (1)G(4) level is populated by the radiative relaxation of the higher energy excited states I-1(6), P-3(0), P-3(1), and P-3(2) of Tm3+ ions. C1 [Glinka, Y. D.] Natl Acad Sci Ukraine, Inst Phys, UA-03028 Kiev, Ukraine. [Everitt, H. O.] USA, Aviat & Missile RDEC, Redstone Arsenal, AL 35809 USA. [Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [Lee, D. S.; Steckl, A. J.] Univ Cincinnati, Nanoelect Lab, Cincinnati, OH 45221 USA. RP Glinka, YD (reprint author), Natl Acad Sci Ukraine, Inst Phys, UA-03028 Kiev, Ukraine. EM yuridglinka@yahoo.com RI Everitt, Henry/L-7118-2013; OI Everitt, Henry/0000-0002-8141-3768; Steckl, Andrew/0000-0002-1868-4442 FU U.S. Army Research Office [DAAD19-03-1-0101] FX One of the authors (Y.D.G.) gratefully acknowledges support from the U. S. Army Aviation and Missile RDEC. The work at Cincinnati was supported in part by the U.S. Army Research Office (Contract No. DAAD19-03-1-0101). NR 13 TC 5 Z9 6 U1 0 U2 6 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAR PY 2009 VL 79 IS 11 AR 113202 DI 10.1103/PhysRevB.79.113202 PG 4 WC Physics, Condensed Matter SC Physics GA 427GX UT WOS:000264768900010 ER PT J AU DeSilva, AW Vunni, GB AF DeSilva, Alan W. Vunni, G. B. TI Electrical conductivity of carbon plasma SO PHYSICAL REVIEW E LA English DT Article DE carbon; discharges (electric); electrical conductivity; hydrodynamics; plasma density; plasma pressure; plasma theory; water ID RESISTIVITY MEASUREMENTS; ALUMINUM PLASMAS; DENSE ALUMINUM; STATE AB The electrical conductivity of carbon plasmas is measured in the range of densities from about 0.6 solid density down to about 0.05 solid density, and reported for values of internal energy ranging from 2 to 22 kJ/gm. Plasmas are formed by rapid electrical discharge through thin graphite fibers immersed in a water bath. The pressure in the expanding plasma column is determined by use of a hydrodynamic model to describe the effect on the water surround. It is found that at constant internal energy per unit mass U, conductivity sigma varies with specific volume v as sigma=v(-alpha), where alpha is about 1 for U < 6 kJ/gm, and rises to about 1.5 for U=22 kJ/gm. C1 [DeSilva, Alan W.] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. [Vunni, G. B.] USA, Res Lab, Aberdeen Proving Ground, MD 20005 USA. RP DeSilva, AW (reprint author), Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. FU U. S. Army Research Laboratory, Aberdeen, MD FX We wish to acknowledge the contribution of A. D. Rakhel for suggesting the hydrodymanic approach to determination of pressures that was used in this work. This work was supported by the U. S. Army Research Laboratory, Aberdeen, MD. NR 17 TC 4 Z9 4 U1 1 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD MAR PY 2009 VL 79 IS 3 AR 036403 DI 10.1103/PhysRevE.79.036403 PG 5 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 427GI UT WOS:000264767400057 PM 19392060 ER PT J AU Kaempfer, TU Plapp, M AF Kaempfer, Thomas U. Plapp, Mathis TI Phase-field modeling of dry snow metamorphism SO PHYSICAL REVIEW E LA English DT Article DE crystal microstructure; diffusion; heat transfer; porous materials; snow; sublimation; thermal conductivity ID TEMPERATURE-GRADIENT METAMORPHISM; ICE; SOLIDIFICATION; CRYSTALS; MICROSTRUCTURE; SIMULATIONS; EVOLUTION; GROWTH; HEAT AB Snow on the ground is a complex three-dimensional porous medium consisting of an ice matrix formed by sintered snow crystals and a pore space filled with air and water vapor. If a temperature gradient is imposed on the snow, a water vapor gradient in the pore space is induced and the snow microstructure changes due to diffusion, sublimation, and resublimation: the snow metamorphoses. The snow microstructure, in turn, determines macroscopic snow properties such as the thermal conductivity of a snowpack. We develop a phase-field model for snow metamorphism that operates on natural snow microstructures as observed by computed x-ray microtomography. The model takes into account heat and mass diffusion within the ice matrix and pore space, as well as phase changes at the ice-air interfaces. Its construction is inspired by phase-field models for alloy solidification, which allows us to relate the phase-field to a sharp-interface formulation of the problem without performing formal matched asymptotics. To overcome the computational difficulties created by the large difference between diffusional and interface-migration time scales, we introduce a method for accelerating the numerical simulations that formally amounts to reducing the heat- and mass-diffusion coefficients while maintaining the correct interface velocities. The model is validated by simulations for simple one- and two-dimensional test cases. Furthermore, we perform qualitative metamorphism simulations on natural snow structures to demonstrate the potential of the approach. C1 [Kaempfer, Thomas U.] ERDC CRREL, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Plapp, Mathis] Ecole Polytech, CNRS, F-91128 Palaiseau, France. RP Kaempfer, TU (reprint author), ERDC CRREL, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM thomas.kaempfer@usace.army.mil; mathis.plapp@polytechnique.fr FU U. S. Army Basic Research Terrain Properties and Processes Program; Oak Ridge Institute for Science and Education; U. S. Department of Energy; USACRREL; U. S. Army Engineer Research and Development Center Major Shared Resource Center; Information Technology Laboratory, Vicksburg, Mississippi FX The computed x-ray microtomography snow images were measured in collaboration with Martin Schneebeli at the WSL Institute for Snow and Avalanche Research SLF, Davos, Switzerland. This project was funded by the U. S. Army Basic Research Terrain Properties and Processes Program and has been supported in part by an appointment to the Research Participation Program at the USACRREL administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and USACRREL. This work was supported in part by an allocation of computer time from the Department of Defense High Performance Computing Modernization Program at the U. S. Army Engineer Research and Development Center Major Shared Resource Center, Information Technology Laboratory, Vicksburg, Mississippi. NR 46 TC 26 Z9 26 U1 1 U2 16 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 EI 1550-2376 J9 PHYS REV E JI Phys. Rev. E PD MAR PY 2009 VL 79 IS 3 AR 031502 DI 10.1103/PhysRevE.79.031502 PN 1 PG 17 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 427GH UT WOS:000264767300069 PM 19391945 ER PT J AU Armstrong, SC Wynn, GH Sandson, NB AF Armstrong, Scott C. Wynn, Gary H. Sandson, Neil B. TI Pharmacokinetic Drug Interactions of Synthetic Opiate Analgesics SO PSYCHOSOMATICS LA English DT Article ID HUMAN LIVER-MICROSOMES; IN-VITRO; PLASMA-CONCENTRATIONS; CLINICAL REALITY; N-DEMETHYLATION; METHADONE; MEPERIDINE; TRAMADOL; CYP2D6; DEXTROPROPOXYPHENE AB Earlier reviews have covered pharmacokinetic drug interactions of natural and semi-synthetic opioid analgesics. This review will focus on the pharmacokinetic drug-drug interactions of methadone, propoxyphene, levomethadyl, meperidine, other phenylpiperidines (such as fentanyl), pentazocine, diphenoxylate, loperimide, and tramadol. The authors present an extensive review of the current literature. These drugs, with a few exceptions, are, at least partially, if not primarily, metabolized by the cytochrome P450 isoenzyme system (CYP) 3A4, and the action/interaction of these enzymes can have an effect on outcome. Therefore, these drugs are likely to produce drug-drug interactions when the CYP3A4 system is inhibited or induced. Knowledge of these drug-drug interactions is important because such interactions may decrease drug efficacy or result in adverse effects. (Psychosomatics 2009; 50:169-176) C1 [Wynn, Gary H.] Walter Reed Army Med Ctr, Dept Psychiat, Inpatient Psychiat Serv, Washington, DC 20307 USA. [Wynn, Gary H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Armstrong, Scott C.] Tual Forest Grove Hosp, Ctr Geriatr Psychiat, Forest Grove, OR USA. [Armstrong, Scott C.] Oregon Hlth & Sci Univ, Portland, OR USA. [Sandson, Neil B.] Univ Maryland, Dept Psychiat, College Pk, MD 20742 USA. RP Wynn, GH (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, Inpatient Psychiat Serv, Washington, DC 20307 USA. EM wynn.md@gmail.com RI Wynn, Gary/B-3618-2011 NR 52 TC 21 Z9 25 U1 1 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD MAR-APR PY 2009 VL 50 IS 2 BP 169 EP 176 PG 8 WC Psychiatry; Psychology SC Psychiatry; Psychology GA 434JG UT WOS:000265270400012 PM 19377028 ER PT J AU Smith, R AF Smith, Roger TI SUPERCOMPUTING ON YOUR DESKTOP SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Editorial Material C1 [Smith, Roger] US Army Simulat Training & Instrumentat, Orlando, FL USA. RP Smith, R (reprint author), US Army Simulat Training & Instrumentat, Orlando, FL USA. EM rdsmith@modelbenders.com NR 3 TC 0 Z9 0 U1 0 U2 0 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 EI 1930-0166 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD MAR-APR PY 2009 VL 52 IS 2 BP 9 EP 12 PG 4 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA 413PN UT WOS:000263805100004 ER PT J AU Allan, PF Hollingsworth, MJ Maniere, GC Rakofsky, AK Chung, KK Naworol, GA Ward, JA Perello, M Morris, MJ AF Allan, Patrick F. Hollingsworth, Michael J. Maniere, Gordon C. Rakofsky, Anthony K. Chung, Kevin K. Naworol, Gregory A. Ward, John A. Perello, Michelle Morris, Michael J. TI Airway Humidification During High-Frequency Percussive Ventilation SO RESPIRATORY CARE LA English DT Article DE high-frequency percussive ventilation; high-frequency ventilation; airway humidification AB BACKGROUND: We were concerned about the risk of inadequate humidification during high-frequency percussive ventilation (HFPV). METHODS: We studied 5 humidifiers during HFPV with a lung model, at bias gas flows of 10 L/min, 30 L/min, and 50 L/min, and compared the results to those from a comparator ventilator/humidifier setup and to the minimum temperature (30 degrees C) and humidity (30 g/L) recommended by the American Association for Respiratory Care, at both regular room temperature and a high ambient temperature. Temperature was measured at the humidifier outflow point and at the artificial carina. Humidity was measured at the artificial carina. RESULTS: Of the 7 HFPV/humidifier combinations, 2 (the MR850 at a bias flow of 50 L/min, and the ConchaTherm Hi-Flow with VDR nebulizer) provided a carinal temperature equivalent to the comparator setup at room temperature, whereas one HFPV/humidifier combination (the ConchaTherm Hi-Flow with modified programming, at bias flows of 30 L/min and 50 L/min) provided a higher carinal temperature. At high ambient temperature, all of the setups delivered lower carinal temperature than the comparator setup. Only 2 setups (the ConchaTherm with modified programming at a bias flow of 50 L/min, and the ConchaTherm Hi-Flow with VDR nebulizer) provided carinal humidification equivalent to the comparator setup, without regard to ambient temperature; the other humidifiers were less effective. The ConchaTherm with modified programming, and the ConchaTherm with the VDR nebutizer provided the most consistent humidification. CONCLUSION: HFPV's distinctive gas-flow mechanism may impair gas heating and humidification, so all humidification systems should be tested with HFPV prior to clinical use. C1 [Allan, Patrick F.; Perello, Michelle] Landstuhl Reg Med Ctr, Pulm Serv, D-09180 APO AE, Germany. [Hollingsworth, Michael J.; Maniere, Gordon C.; Naworol, Gregory A.] Dept Resp Therapy, Lackland AFB, TX USA. [Rakofsky, Anthony K.; Chung, Kevin K.; Ward, John A.; Morris, Michael J.] Brooke Army Med Ctr, US Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Allan, PF (reprint author), Landstuhl Reg Med Ctr, Pulm Serv, CMR 402,Box 307, D-09180 APO AE, Germany. EM patrick.allan@amedd.army.mil NR 5 TC 10 Z9 10 U1 0 U2 2 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD MAR PY 2009 VL 54 IS 3 BP 350 EP 358 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 417XU UT WOS:000264112600009 PM 19245729 ER PT J AU Weichel, ED Colyer, MH AF Weichel, Eric D. Colyer, Marcus H. TI TRAUMATIC MACULAR HOLES SECONDARY TO COMBAT OCULAR TRAUMA SO RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES LA English DT Article ID LIMITING MEMBRANE REMOVAL; VITREOUS SURGERY; MANAGEMENT AB Purpose: This study reports on the visual impact of combat related traumatic macular hole formation at a single tertiary referral center. Methods: Retrospective, noncomparative, interventional consecutive case series. Results: Seventeen of 432 consecutive traumatic macular holes occurred in 387 United States soldiers during Operations Iraqi and Enduring Freedom between March 2003 and October 2006. The median age was 28 +/- 9 years (range, 19-49 years) and the median follow-up was 292 +/- 453 days (range, 59-1640 days). Closed-globe macular holes equaled 11 of 234 cases (5%), and open-globe macular holes were 6 of 198 (3%). Traumatic macular hole was associated with a retinal detachment in 8 of 17 cases (47%). The overall documented macular hole closure rate was 9 of 15 cases (60%). There was no statistical difference in hole closure rates between surgery and observation (P = 0.34). Severe nonocular injuries occurred in 12 of 17 (71 %), with the median time to macular hole surgical repair of 18 +/- 37 days (range, 7-132). There was a significant positive association between the Ocular Trauma Score equal to or greater than 80 and a best-corrected visual acuity of 20/200 or greater (r = 0.87, n = 15; P < 0.005). Conclusion: Traumatic macular hole occurs in both open and closed globe combat trauma with high rates of nonocular injuries. Visual outcome is highly variable despite macular hole closure in a majority of patients due to concomitant globe injuries. The Ocular Trauma Score is useful in predicting final visual acuity and traumatic macular hole closure. C1 [Weichel, Eric D.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. RP Weichel, ED (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM eweichel@hotmail.com NR 20 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0275-004X J9 RETINA-J RET VIT DIS JI Retin.-J. Retin. Vitr. Dis. PD MAR PY 2009 VL 29 IS 3 BP 349 EP 354 PG 6 WC Ophthalmology SC Ophthalmology GA 420RK UT WOS:000264306700011 PM 18997638 ER PT J AU Feroli, T Litz, MS Merkel, G Smith, T Pereira, NR Carroll, JJ AF Feroli, T. Litz, M. S. Merkel, G. Smith, T. Pereira, N. R. Carroll, J. J. TI Megavoltage bremsstrahlung end point voltage diagnostic SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article DE accelerator magnets; bremsstrahlung; Compton effect; dosimetry; electron accelerators; linear accelerators; particle beam diagnostics; X-ray spectrometers ID DIFFERENTIAL ABSORPTION SPECTROMETER; NUCLEAR ISOMERS AB In a material, a beam of x rays is accompanied by various kinds of secondary radiation, including Compton electrons from collisions between the x rays and the material's electrons. For megavoltage bremsstrahlung in air, many of these Compton electrons are forward-directed and fast enough to be deflected outside the beam's edge by a magnetic field perpendicular to the beam. At the beam's edge, the dose from the deflected Compton electrons has a pattern that depends on the radiation's end point energy. Dose patterns measured with radiochromic film on a nominally 1 and 2 MV linear accelerator agree reasonably well with the corresponding Monte Carlo computations. With further development, the dose pattern produced outside the beam by such a sweeper magnet could become a noninvasive way to monitor megavoltage bremsstrahlung, when the end point energies are difficult to determine with other methods. C1 [Feroli, T.; Litz, M. S.; Merkel, G.; Smith, T.] USA, Res Lab, Adelphi, MD 20873 USA. [Pereira, N. R.] Ecopulse Inc, Springfield, VA 22150 USA. [Carroll, J. J.] Youngstown State Univ, Youngstown, OH 44555 USA. RP Feroli, T (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20873 USA. EM pereira@speakeasy.net FU Naval Research Laboratory [W911QX07C0002] FX We thank Dr. D. Murphy at the Naval Research Laboratory for the TLD calibrations and acknowledge the support for NRP under Contract No. W911QX07C0002 from ARL. NR 12 TC 1 Z9 1 U1 1 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD MAR PY 2009 VL 80 IS 3 AR 034301 DI 10.1063/1.3098947 PG 11 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 427JW UT WOS:000264776600038 PM 19334938 ER PT J AU Cowan, DN Weber, NS Bedno, SA Cavicchia, MA Yolken, R Niebuhr, DW AF Cowan, David N. Weber, N. S. Bedno, S. A. Cavicchia, M. A. Yolken, R. Niebuhr, D. W. TI ADULT-ONSET SCHIZOPHRENIA IN THE US MILITARY: PATTERNS BY SEX, RACE AND AGE SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 12th International Congress on Schizophrenia Research CY MAR 28-APR 01, 2009 CL San Diego, CA C1 [Cowan, David N.; Weber, N. S.; Bedno, S. A.; Cavicchia, M. A.; Niebuhr, D. W.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Yolken, R.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2009 VL 35 BP 66 EP 66 PG 1 WC Psychiatry SC Psychiatry GA 415VP UT WOS:000263964700195 ER PT J AU Weber, N Cowan, DN Bedno, SA Cavicchia, MA Yolken, R Niebuhr, DW AF Weber, Natalya Cowan, D. N. Bedno, S. A. Cavicchia, M. A. Yolken, R. Niebuhr, D. W. TI DESCRIPTIVE EPIDEMIOLOGY AND COMORBIDITY OF SCHIZOPHRENIA VS. BIPOLAR DISORDER IN THE NATIONAL HOSPITAL DISCHARGE SURVEY (NHDS) SO SCHIZOPHRENIA BULLETIN LA English DT Meeting Abstract CT 12th International Congress on Schizophrenia Research CY MAR 28-APR 01, 2009 CL San Diego, CA C1 [Weber, Natalya; Cowan, D. N.; Bedno, S. A.; Cavicchia, M. A.; Niebuhr, D. W.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Yolken, R.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD MAR PY 2009 VL 35 BP 66 EP 66 PG 1 WC Psychiatry SC Psychiatry GA 415VP UT WOS:000263964700194 ER PT J AU Blank, S AF Blank, Stephen TI The Rebuilding of Greater Russia: Putin's Foreign Policy towards the CIS Countries SO SLAVIC REVIEW LA English DT Book Review C1 [Blank, Stephen] USA, War Coll, Washington, DC USA. RP Blank, S (reprint author), USA, War Coll, Washington, DC USA. NR 1 TC 0 Z9 0 U1 2 U2 4 PU UNIV ILLINOIS, URBANA-CHAMPAIGN PI URBANA PA 1207 W OREGON ST, URBANA, IL 61801-3716 USA SN 0037-6779 J9 SLAVIC REV JI Slavic Rev. PD SPR PY 2009 VL 68 IS 1 BP 210 EP 211 PG 2 WC Area Studies; Humanities, Multidisciplinary SC Area Studies; Arts & Humanities - Other Topics GA 414GB UT WOS:000263850800068 ER PT J AU Rupp, TL Wesensten, NJ Bliese, PD Balkin, TJ AF Rupp, Tracy L. Wesensten, Nancy J. Bliese, Paul D. Balkin, Thomas J. TI Banking Sleep: Realization of Benefits During Subsequent Sleep Restriction and Recovery SO SLEEP LA English DT Article DE Sleep restriction; partial sleep deprivation; cognitive performance; sleep extension; recovery sleep; discontinuous growth modeling ID DOSE-RESPONSE; REACTION-TIME; DEPRIVATION; PERFORMANCE; PATTERNS; EEG; AGE AB Objective: Determine whether sleep extension (a) improves alertness and performance during subsequent sleep restriction and (b) impacts the rate at which alertness and performance are restored by post-restriction recovery sleep. Design: Participants were randomly assigned to an Extended (10 h time in bed [TIB]) or Habitual TIB (mean (SD) hours = 7.09 (0.7)] sleep group for one week, followed by 1 Baseline (10 hours or habitual TIB), 7 Sleep Restriction (3 h TIB), and 5 Recovery Sleep nights (8 h TIB). Performance and alertness tests were administered hourly between 08:00-18:00 during all in-laboratory phases of the study. Setting: Residential sleep/performance testing facility. Participants: Twenty-four healthy adults (ages 18-39) participated in the study. Interventions: Extended vs. habitual sleep durations prior to sleep restriction. Results: Psychomotor vigilance task (PVT) lapses were more frequent and modified maintenance of wakefulness (MWT) sleep latency was shorter in the Habitual group than in the Extended group across the sleep restriction phase. During the Recovery phase, PVT speed rebounded faster (and PVT lapsing recovered significantly after the first night of recovery sleep) in the Extended group. No group differences in subjective sleepiness were evident during any phase of the study. Conclusion: The extent to which sleep restriction impairs objectively measured alertness and performance, and the rate at which these impairments are subsequently reversed by recovery sleep, varies as a function of the amount of nightly sleep obtained prior to the sleep restriction period. This suggests that the physiological mechanism(s) underlying chronic sleep debt undergo long-term (days/weeks) accommodative/adaptive changes. C1 [Rupp, Tracy L.] Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Rupp, TL (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, Rm 2w88,503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM tracy.rupp@amedd.army.mil RI Rupp, Tracy/B-3605-2011 FU US Army Medical Research and Materiel Command FX This material has been reviewed by the Walter Reed Army Institute of Research, and there is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the position of the Department of the Army of the Department of Defense. NR 30 TC 66 Z9 66 U1 0 U2 5 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD MAR 1 PY 2009 VL 32 IS 3 BP 311 EP 321 PG 11 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 412ED UT WOS:000263705500005 PM 19294951 ER PT J AU DaCunha, JJ Gibbs, SG AF DaCunha, J. J. Gibbs, S. G. TI Modeling a Finite-Length Sucker Rod Using the Semi-Infinite-Wave Equation and a Proof of Gibbs' Conjecture SO SPE JOURNAL LA English DT Article; Proceedings Paper CT 2007 SPE Annual Technical Conference and Exhibition CY NOV 11-14, 2007 CL Anaheim, CA SP SPE ID DIAGNOSIS; WELLS AB In this paper, we study semi-infinite-spatial-domain wave equations modeling the real-world problem of longitudinal waves propagating along a long, slender, homogeneous elastic rod of finite length. A practical conclusion from the paper is that precision of the downhole card can be increased by improving the accuracy of the friction law in the wave equation. To conclude, we provide a rigorous proof of Gibbs' theorem and illustrate its validity with an existing well. C1 [DaCunha, J. J.] US Mil Acad, West Point, NY 10996 USA. NR 16 TC 5 Z9 5 U1 1 U2 1 PU SOC PETROLEUM ENG PI RICHARDSON PA 222 PALISADES CREEK DR,, RICHARDSON, TX 75080 USA SN 1086-055X J9 SPE J JI SPE J. PD MAR PY 2009 VL 14 IS 1 BP 112 EP 119 PG 8 WC Engineering, Petroleum SC Engineering GA 469MT UT WOS:000267904200013 ER PT J AU Pak, HS Datta, SK Triplett, CA Lindquist, JH Grambow, SC Whited, JD AF Pak, Hon S. Datta, Santanu K. Triplett, Crystal A. Lindquist, Jennifer H. Grambow, Steven C. Whited, John D. TI Cost Minimization Analysis of a Store-and-Forward Teledermatology Consult System SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Article DE teledermatology; store-and-forward system; cost-savings ID RANDOMIZED CONTROLLED-TRIAL; REALTIME TELEDERMATOLOGY; CONVENTIONAL CARE; SERVICE AB The aim of this study was to perform a cost minimization analysis of store-and-forward teledermatology compared to a conventional dermatology referral process (usual care). In a Department of Defense (DoD) setting, subjects were randomized to either a teledermatology consult or usual care. Accrued healthcare utilization recorded over a 4-month period included clinic visits, teledermatology visits, laboratories, preparations, procedures, radiological tests, and medications. Direct medical care costs were estimated by combining utilization data with Medicare reimbursement rates and wholesale drug prices. The indirect cost of productivity loss for seeking treatment was also included in the analysis using an average labor rate. Total and average costs were compared between groups. Teledermatology patients incurred $103,043 in total direct costs ($294 average), while usual-care patients incurred $98,365 ($283 average). However, teledermatology patients only incurred $16,359 ($47 average) in lost productivity cost while usual-care patients incurred $30,768 ($89 average). In total, teledermatology patients incurred $119,402 ($340 average) and usual-care patients incurred $129,133 ($372 average) in costs. From the economic perspective of the DoD, store-and-forward teledermatology was a cost-saving strategy for delivering dermatology care compared to conventional consultation methods when productivity loss cost is taken into consideration. C1 [Pak, Hon S.] Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Datta, Santanu K.; Whited, John D.] Duke Univ, Med Ctr, Div Gen Internal Med, Vet Affairs Med Ctr,Ctr Hlth Serv Res Primary Car, Durham, NC 27710 USA. [Triplett, Crystal A.] Brooke Army Med Ctr, Dept Dermatol, Ft Sam Houston, TX 78234 USA. [Grambow, Steven C.] Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Vet Affairs Med Ctr,Ctr Hlth Serv Res Primary Car, Durham, NC 27710 USA. RP Datta, SK (reprint author), VA Med Ctr 152, 508 Fulton St, Durham, NC 27705 USA. EM datta@mc.duke.edu RI Grambow, Steven/E-1422-2015 OI Grambow, Steven/0000-0001-6037-3253 FU U. S. Army's Telemedicine; Advanced Technology Research Center, Fort Detrick, Maryland FX This study was funded by the U. S. Army's Telemedicine and Advanced Technology Research Center, Fort Detrick, Maryland. NR 14 TC 27 Z9 28 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD MAR PY 2009 VL 15 IS 2 BP 160 EP 165 DI 10.1089/tmj.2008.0083 PG 6 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 420IX UT WOS:000264284000043 PM 19292625 ER PT J AU Logue, BA Maserek, WK Rockwood, GA Keebaugh, MW Baskin, SI AF Logue, Brian A. Maserek, Wendy K. Rockwood, Gary A. Keebaugh, Michael W. Baskin, Steven I. TI The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE 2-amino-2-thiazoline-4-carboxylic acid; ATCA; Biomarker; Cyanide; Gas-chromatography mass-spectrometry ID METABOLITE 2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID; PERFORMANCE LIQUID-CHROMATOGRAPHY; 2-IMINOTHIAZOLIDINE-4-CARBOXYLIC ACID; WHOLE-BLOOD; CYANIDE CONCENTRATIONS; THIOCYANATE; URINE; EXPOSURE; ANIMALS; SMOKING AB ATCA (2-amino-2-thiazoline-4-carboxylic acid) is a promising marker to assess cyanide exposure because of several advantages of ATCA analysis over direct determination of cyanide and alternative cyanide biomarkers (i.e. stability in biological matrices, consistent recovery, and relatively small endogenous concentrations). Concentrations of ATCA in the plasma of smoking and non-smoking human volunteers were analyzed using gas-chromatography mass-spectrometry to establish the feasibility of using ATCA as a marker for cyanide exposure. The levels of ATCA in plasma of smoking volunteers, 17.2 ng/ml, were found to be significantly (p < 0.001) higher than that of non-smoking volunteers, 11.8 ng/ml. Comparison of ATCA concentrations of smokers relative to nonsmokers in both urine and plasma yielded relatively similar results. The concentration ratio of ATCA for smokers versus non-smokers in plasma and urine was compared to similar literature studies of cyanide and thiocyanate, and correlations are discussed. This study supports previous evidence that ATCA can be used to determine past cyanide exposure and indicates that further studies should be pursued to validate the use of ATCA as a marker of cyanide exposure. C1 [Logue, Brian A.; Maserek, Wendy K.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Rockwood, Gary A.; Keebaugh, Michael W.; Baskin, Steven I.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu NR 41 TC 14 Z9 15 U1 1 U2 14 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD MAR PY 2009 VL 19 IS 3 BP 202 EP 208 DI 10.1080/15376510802488165 PG 7 WC Toxicology SC Toxicology GA 453SF UT WOS:000266631100003 PM 19730703 ER PT J AU Stromberg, JC Hazelton, AF White, MS White, JM Fischer, RA AF Stromberg, Juliet C. Hazelton, Andrea F. White, Margaret S. White, Jacqueline M. Fischer, Richard A. TI EPHEMERAL WETLANDS ALONG A SPATIALLY INTERMITTENT RIVER: TEMPORAL PATTERNS OF VEGETATION DEVELOPMENT SO WETLANDS LA English DT Article DE dryland river; intermittent flow; riparian vegetation; seed bank; temporary stream ID SEED BANK DYNAMICS; SAN-PEDRO RIVER; RIPARIAN VEGETATION; PLANT DISPERSAL; DESERT FLOODPLAIN; SURFACE-WATER; SOUTH-AFRICA; ARIZONA; RESTORATION; HYDROCHORY AB Dryland rivers arc characterized by high spatio-temporal variability ill water resources, With alternating wet and dry reaches and fluctuating stream flow rates. To investigate response to this dynamic. riparian plant communities from perennial, temporally intermittent. and ephemeral-flow reaches of the Hassayampa River and an ephemeral tributary (southwestern USA) were characterized over a three year period. and soil seed banks (emergence method) were assessed. Variance through time in cover and diversity of wetland (hydric) species was lowest at perennial sites and highest at ephemeral flow sites. Wetland plants established along the active channel of the ephemeral reach Following a 10-year recurrence interval flood, and compositional similarity between perennial and ephemeral sites was high during this wet year. About half of the wetland species growing at ephemeral flow sites were present ill floodplain soil seed banks. Wetland species emerged from soils of the ephemeral Hassayampa River (but not of the ephemeral tributary) but their density Mid diversity declined with distance downstream of the perennial reach. Wetland species ill the seed banks of ephemeral-flow sites were a nested subset those at wetter sites, raising the possibility of dispersal from upstream sites. These results indicate that wetlands develop episodically oil ephemeral reaches of spatially intermittent rivers of the Sonoran Desert following high winter runoff, and suggest that the wetland plants arise from local seed banks and off-site sources. The study also suggests that riverine restoration success is sensitive to location within a stream network: upon re-watering, sites closer to perennial reaches will have greater capacity to self-assemble wetland plant communities. C1 [Stromberg, Juliet C.; Hazelton, Andrea F.; White, Margaret S.; White, Jacqueline M.] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA. [Fischer, Richard A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Stromberg, JC (reprint author), Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA. EM jstrom@asu.edu NR 58 TC 13 Z9 13 U1 1 U2 19 PU SOC WETLAND SCIENTISTS PI LAWRENCE PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 USA SN 0277-5212 J9 WETLANDS JI Wetlands PD MAR PY 2009 VL 29 IS 1 BP 330 EP 342 PG 13 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 434SN UT WOS:000265294500033 ER PT J AU Gurjala, AN Leung, KP Galiano, RD Mustoe, TA AF Gurjala, Anandev N. Leung, Kai P. Galiano, Robert D. Mustoe, Thomas A. TI STAPHYLOCOCCUS AUREUS AND EPIDERMIDIS BACTERIAL BIOFILMS DELAY WOUND HEALING IN A NOVEL MODEL IN RABBIT SO WOUND REPAIR AND REGENERATION LA English DT Meeting Abstract C1 [Gurjala, Anandev N.; Galiano, Robert D.; Mustoe, Thomas A.] NW Feinberg Sch Med, Chicago, IL USA. [Leung, Kai P.] US Army Dent & Trauma Res Detachment, Microbiol & Immunol Branch, Walter Reed Army Inst Res, Great Lakes Naval Training Stn, Great Lakes, IL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1067-1927 J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD MAR-APR PY 2009 VL 17 IS 2 BP A26 EP A26 PG 1 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA 418ZJ UT WOS:000264188600083 ER PT J AU Lee, PJ Bhonsle, JB Gaona, HW Huddler, DP Heady, TN Kreishman-Deitrick, M Bhattacharjee, A McCalmont, WF Gerena, L Lopez-Sanchez, M Roncal, NE Hudson, TH Johnson, JD Prigge, ST Waters, NC AF Lee, Patricia J. Bhonsle, Jayendra B. Gaona, Heather W. Huddler, Donald P. Heady, Tiffany N. Kreishman-Deitrick, Mara Bhattacharjee, Apurba McCalmont, William F. Gerena, Lucia Lopez-Sanchez, Miriam Roncal, Norma E. Hudson, Thomas H. Johnson, Jacob D. Prigge, Sean T. Waters, Norman C. TI Targeting the Fatty Acid Biosynthesis Enzyme, beta-Ketoacyl-Acyl Carrier Protein Synthase III (PfKASIII), in the Identification of Novel Antimalarial Agents SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID PARASITE PLASMODIUM-FALCIPARUM; CRYSTAL-STRUCTURE; FUNCTIONAL-CHARACTERIZATION; BIOLOGICAL PROPERTIES; ANTIBIOTIC PROPERTIES; ANTIMICROBIAL AGENTS; TOXOPLASMA-GONDII; POTENT INHIBITORS; ESCHERICHIA-COLI; ACP REDUCTASE AB The importance of fatty acids to the human malaria parasite, Plasmodium falciparum, and differences due to a type I fatty acid synthesis (FAS) pathway in the parasite, make it an attractive drug target. In the present study, we developed and a utilized a pharmacophore to select compounds for testing against PfKASIII, the initiating enzyme of FAS. This effort identified several PfKASIII inhibitors that grouped into various chemical classes of sulfides, sulfonamides, and sulfonyls. Approximately 60% of the submicromolar inhibitors of PfKASIII inhibited in vitro growth of the malaria parasite. These compounds inhibited both drug sensitive and resistant parasites and testing against a mammalian cell line revealed an encouraging in vitro therapeutic index for the most active compounds. Docking studies into the active site of PfKASIII suggest a potential binding mode that exploits amino acid residues at the mouth of the substrate tunnel. C1 [Lee, Patricia J.; Bhonsle, Jayendra B.; Gaona, Heather W.; Huddler, Donald P.; Heady, Tiffany N.; Kreishman-Deitrick, Mara; Bhattacharjee, Apurba; McCalmont, William F.; Gerena, Lucia; Lopez-Sanchez, Miriam; Roncal, Norma E.; Hudson, Thomas H.; Johnson, Jacob D.; Waters, Norman C.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Prigge, Sean T.] Johns Hopkins Bloomberg Sch Publ Hlth, Malaria Res Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. RP Waters, NC (reprint author), Australian Army Malaria Inst, Weary Dunlop Dr, Enoggera, Qld, Australia. EM norman.waters@us.army.mil RI Bhonsle, Jayendra/A-9139-2011; Hudson, Thomas/A-9152-2011 FU NIAID NIH HHS [R01 AI065853, R01 AI065853-04] NR 60 TC 32 Z9 32 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD FEB 26 PY 2009 VL 52 IS 4 BP 952 EP 963 DI 10.1021/jm8008103 PG 12 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 409UB UT WOS:000263530200009 PM 19191586 ER PT J AU Bell, BA Wood, JF Bansal, R Ragab, H Cargo, J Washington, MA Wood, CL Ware, LA Ockenhouse, CF Yadava, A AF Bell, Brian A. Wood, James F. Bansal, Reeta Ragab, Hatem Cargo, John Washington, Michael A. Wood, Chloe L. Ware, Lisa A. Ockenhouse, Christian F. Yadava, Anjali TI Process development for the production of an E. coli produced clinical grade recombinant malaria vaccine for Plasmodium vivax SO VACCINE LA English DT Article DE Vivax vaccine; cGMP; Circumsporozoite protein ID CIRCUMSPOROZOITE PROTEIN VACCINE; RANDOMIZED CONTROLLED-TRIAL; FALCIPARUM MALARIA; CANDIDATE; EFFICACY; CHILDREN; DISEASE; SAFETY AB The global eradication of malaria will require the development of vaccines to prevent infection cause by Plasmodium vivax in addition to Plasmodium falciparum. In an attempt to contribute to this effort we have previously reported the cloning and expression of a vaccine based on the circumsporozoite protein of P vivax. The synthetic vaccine encodes for a full-length molecule encompassing the N-terminal and C-terminal regions flanking a chimeric repeat region representing VK210 and VK247, the two major alleles of P. vivax CSP. The vaccine, designated vivax malaria protein 001 (VMP001), was purified to >95% homogeneity using a three-column purification scheme and had low endotoxin levels and passed the rabbit pyrogenicity assay. The protein is recognized by monoclonal antibodies directed against the two repeat motifs, as well as polyclonal antibodies. Immunization with VMP001 induced high titer antibodies in mice using Montanide ISA 720. We currently have More than 10,000 doses of purified bulk and 1800 vials of formulated bulk vaccine available for clinical testing and VMP001 is currently undergoing further development as a candidate vaccine to prevent malaria in humans. Published by Elsevier Ltd. C1 [Yadava, Anjali] US Mil Malaria Vaccine Program, Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Bell, Brian A.; Wood, James F.; Bansal, Reeta; Ragab, Hatem] Walter Reed Army Inst Res, Pilot Bioprod Facil, Silver Spring, MD 20910 USA. RP Yadava, A (reprint author), US Mil Malaria Vaccine Program, Walter Reed Army Inst Res, Div Malaria Vaccine Dev, 503 Robert Grant Ave,Room 3W63, Silver Spring, MD 20910 USA. EM Anjali.Yadava@us.army.mil FU U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland; Animal Welfare Act FX Research was conducted in compliance with the Animal Welfare Act and other federal Statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals (NRC Publication, 1996 ed.). NR 15 TC 26 Z9 28 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD FEB 25 PY 2009 VL 27 IS 9 BP 1448 EP 1453 DI 10.1016/j.vaccine.2008.12.027 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 422LV UT WOS:000264430400023 PM 19138714 ER PT J AU Leal, AA Deitzel, JM McKnight, SH Gillespie, JW AF Leal, A. Andres Deitzel, Joseph M. McKnight, Steven H. Gillespie, John W., Jr. TI Interfacial behavior of high performance organic fibers SO POLYMER LA English DT Article DE Organic fiber; Interfacial shear strength; Polymer composite materials ID OXYGEN PLASMA TREATMENT; MATRIX ADHESION; BONDING MECHANISM; MICROBOND METHOD; RESIN INTERFACE; SHEAR-STRENGTH; EPOXY MATRICES; ARAMID FIBERS; COMPOSITES; INTERPHASE AB The surface and interfacial properties of different high performance fibers of current interest have been analyzed. The pyridobisimidazole fiber M5 shows a markedly higher polar contribution to its surface free energy than the rest of the organic fibers under study. Interfacial shear strength (IFSS) values measured by means of the microdroplet test indicate that M5 fiber has an IFSS that doubles that of the Kevlar fibers, in agreement with the observed results from surface free energy tests. Armos fiber, a para-aramid material that incorporates imidazole functional groups, shows an average IFSS 30-35% higher than the Kevlar fibers. SEM micrographs of failed microdroplet specimens show different failure mechanisms for the Kevlar KM2, Armos and M5 fibers. The KM2 specimens fail due to complete detachment of surface fibrils from the bulk of the fiber, while Armos specimens fail by the combined effect of microfibrillation on the fiber surface coupled with adhesive failure. In contrast, M5 microdroplet specimens exhibit failure surfaces consisting of partial matrix yielding during droplet debonding, indicative of the high level of interfacial bonding to the surface and higher levels of hydrogen bonding within the fiber that suppress microfibrillation. The higher polar character of the M5 surface can lead to the presence of an interphase region with different mechanical properties from the bulk matrix. (c) 2009 Elsevier Ltd. All rights reserved. C1 [Leal, A. Andres; Deitzel, Joseph M.; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Leal, A. Andres; Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [McKnight, Steven H.] USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM gillespi@udel.edu FU US Army Research laboratory [DAAD19-01-2-0005] FX The authors wish to acknowledge the financial support provided by the Composite Materials Technology (CMT) Collaborative Program sponsored by the US Army Research laboratory under Cooperative Agreement DAAD19-01-2-0005. Additionally, the authors would like to thank Dr. Philip Cunniff for providing the M5" fiber and Dr. Sergey Lopatnikov for his help in obtaining the AriTlos' fiber. NR 23 TC 34 Z9 35 U1 6 U2 45 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD FEB 23 PY 2009 VL 50 IS 5 BP 1228 EP 1235 DI 10.1016/j.polymer.2009.01.018 PG 8 WC Polymer Science SC Polymer Science GA 415SR UT WOS:000263955800020 ER PT J AU Yan, XQ Tang, Z Zhang, L Guo, JJ Jin, CQ Zhang, Y Goto, T McCauley, JW Chen, MW AF Yan, X. Q. Tang, Z. Zhang, L. Guo, J. J. Jin, C. Q. Zhang, Y. Goto, T. McCauley, J. W. Chen, M. W. TI Depressurization Amorphization of Single-Crystal Boron Carbide SO PHYSICAL REVIEW LETTERS LA English DT Article ID RAMAN-SPECTROSCOPY; SHOCK COMPRESSION; HIGH-PRESSURE; DIAMOND; B4C AB We report depressurization amorphization of single-crystal boron carbide (B4C) investigated by in situ high-pressure Raman spectroscopy. It was found that localized amorphization of B4C takes place during unloading from high pressures, and nonhydrostatic stresses play a critical role in the high-pressure phase transition. First-principles molecular dynamics simulations reveal that the depressurization amorphization results from pressure-induced irreversible bending of C-B-C atomic chains cross-linking 12 atom icosahedra at the rhombohedral vertices. C1 [Yan, X. Q.; Zhang, L.; Guo, J. J.; Chen, M. W.] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan. [Yan, X. Q.; Zhang, Y.] Univ Sci & Technol Beijing, Dept Mat Phys & Chem, Beijing 100083, Peoples R China. [Tang, Z.] E China Normal Univ, Key Lab Polar Mat & Devices, Shanghai 200062, Peoples R China. [Jin, C. Q.] Chinese Acad Sci, Inst Phys, Beijing 100080, Peoples R China. [Goto, T.; Chen, M. W.] Tohoku Univ, Inst Mat Res, Sendai, Miyagi 9808577, Japan. [McCauley, J. W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chen, MW (reprint author), Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan. EM mwchen@imr.tohoku.ac.jp RI GOTO, TAKASHI/C-2470-2011; Chen, Mingwei/A-4855-2010; guo, junjie/I-3189-2012; TANG, Zheng/B-4518-2014 OI Chen, Mingwei/0000-0002-2850-8872; guo, junjie/0000-0002-3414-3734; TANG, Zheng/0000-0003-1069-7182 NR 30 TC 58 Z9 58 U1 7 U2 51 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD FEB 20 PY 2009 VL 102 IS 7 AR 075505 DI 10.1103/PhysRevLett.102.075505 PG 4 WC Physics, Multidisciplinary SC Physics GA 410SV UT WOS:000263599500041 PM 19257688 ER PT J AU Spillane, M Schoch, R Cooke, M Harvey, T Greenwood, M Kreider, R Willoughby, DS AF Spillane, Mike Schoch, Ryan Cooke, Matt Harvey, Travis Greenwood, Mike Kreider, Richard Willoughby, Darryn S. TI The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Article ID EXERCISE PERFORMANCE; SKELETAL-MUSCLE; MONOHYDRATE SUPPLEMENTATION; METABOLISM; STRENGTH; MASS; RAT AB Numerous creatine formulations have been developed primarily to maximize creatine absorption. Creatine ethyl ester is alleged to increase creatine bio-availability. This study examined how a seven-week supplementation regimen combined with resistance training affected body composition, muscle mass, muscle strength and power, serum and muscle creatine levels, and serum creatinine levels in 30 non-resistance-trained males. In a double-blind manner, participants were randomly assigned to a maltodextrose placebo (PLA), creatine monohydrate (CRT), or creatine ethyl ester (CEE) group. The supplements were orally ingested at a dose of 0.30 g/kg fat-free body mass (approximately 20 g/day) for five days followed by ingestion at 0.075 g/kg fat free mass (approximately 5 g/day) for 42 days. Results showed significantly higher serum creatine concentrations in PLA (p = 0.007) and CRT (p = 0.005) compared to CEE. Serum creatinine was greater in CEE compared to the PLA (p = 0.001) and CRT (p = 0.001) and increased at days 6, 27, and 48. Total muscle creatine content was significantly higher in CRT (p = 0.026) and CEE (p = 0.041) compared to PLA, with no differences between CRT and CEE. Significant changes over time were observed for body composition, body water, muscle strength and power variables, but no significant differences were observed between groups. In conclusion, when compared to creatine monohydrate, creatine ethyl ester was not as effective at increasing serum and muscle creatine levels or in improving body composition, muscle mass, strength, and power. Therefore, the improvements in these variables can most likely be attributed to the training protocol itself, rather than the supplementation regimen. C1 [Spillane, Mike; Cooke, Matt; Greenwood, Mike; Willoughby, Darryn S.] Baylor Univ, Dept Hlth Human Performance & Recreat, Waco, TX 76798 USA. [Willoughby, Darryn S.] Baylor Univ, Inst Biomed Sci, Waco, TX 76798 USA. [Kreider, Richard] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 78743 USA. [Schoch, Ryan] Purdue Univ, Interdept Nutr Program, W Lafayette, IN 47907 USA. [Harvey, Travis] US Mil Acad, Dept Phys Educ, West Point, NY 10096 USA. RP Willoughby, DS (reprint author), Baylor Univ, Dept Hlth Human Performance & Recreat, Box 97313, Waco, TX 76798 USA. EM micheilspillane@hotmail.com; rschoch@purdue.edu; matt_cooke@baylor.edu; Travis.Harvey@usma.edu; mike_greenwood@baylor.edu; rkreider@hlkn.tamu.edu; darryn_willoughby@baylor.edu RI Kreider, Richard/O-1804-2014 OI Kreider, Richard/0000-0002-3906-1658 FU Labrada Nutritionals ( Houston, TX); AST Sport Science ( Colorado Springs, CO) FX We would like to thank the individuals that participated as subjects in this study. This study was supported by supplement donations from Labrada Nutritionals ( Houston, TX) and AST Sport Science ( Colorado Springs, CO) to Baylor University. Written consent for participation was obtained from all subjects. All researchers involved independently collected, analyzed, and interpreted the results from this study and have no financial interests concerning the outcome of the investigation. NR 34 TC 24 Z9 26 U1 0 U2 21 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD FEB 19 PY 2009 VL 6 AR 6 DI 10.1186/1550-2783-6-6 PG 14 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 487OD UT WOS:000269283200001 PM 19228401 ER PT J AU Gong, HG Andrews, RS Zuccarello, JL Lee, SJ Gagne, MR AF Gong, Hegui Andrews, R. Stephen Zuccarello, Joseph L. Lee, Stephen J. Gagne, Michel R. TI Sn-Free Ni-Catalyzed Reductive Coupling of Glycosyl Bromides with Activated Alkenes SO ORGANIC LETTERS LA English DT Article ID ALPHA-C-GLYCOSIDES; SECONDARY ALKYL BROMIDES; CROSS-COUPLINGS; GLYCOSYLTRANSFERASE INHIBITORS; NICKEL; HALIDES; RADICALS; REAGENTS; ACID; CONFORMATION AB A mild, stereoselective method for the Ni-catalyzed synthesis of alpha-C-alkylglycosides is reported. This approach entails the reductive coupling of glycosyl bromides with activated alkenes at room temperature, with low alkene loading as an important feature. Diastereoselective coupling with 2-substituted acrylate derivatives was made possible through the use of 2,4-dimethyl-3-pentanol as a proton source. C1 [Gong, Hegui; Andrews, R. Stephen; Zuccarello, Joseph L.; Gagne, Michel R.] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Lee, Stephen J.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. RP Gagne, MR (reprint author), USA, Res Off, POB 12211, Res Triangle Pk, NC 27709 USA. EM mgagne@unc.edu FU National Research Council for a Postdoctoral Fellowship; Department of Energy [DE-FG02-05ER15630] FX We thank Andrew Parsons (UNC-CH) for his generous donation of compound 40. J.L.Z. thanks the National Research Council for a Postdoctoral Fellowship, S.J.L. thanks the ARO for Staff Research Funding, and M.R.G. thanks the Department of Energy (DE-FG02-05ER15630) for generous support. NR 48 TC 48 Z9 48 U1 6 U2 31 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1523-7060 J9 ORG LETT JI Org. Lett. PD FEB 19 PY 2009 VL 11 IS 4 BP 879 EP 882 DI 10.1021/ol8028737 PG 4 WC Chemistry, Organic SC Chemistry GA 406MG UT WOS:000263299000024 PM 19170565 ER PT J AU Gabel, F Masson, P Froment, MT Doctor, BP Saxena, A Silman, I Zaccai, G Weik, M AF Gabel, F. Masson, P. Froment, M. -T. Doctor, B. P. Saxena, A. Silman, I. Zaccai, G. Weik, M. TI Direct Correlation between Molecular Dynamics and Enzymatic Stability: A Comparative Neutron Scattering Study of Native Human Butyrylcholinesterase and its "Aged" Soman Conjugate SO BIOPHYSICAL JOURNAL LA English DT Article ID PROTEIN DYNAMICS; ACETYLCHOLINESTERASE; CHOLINESTERASES; SIMULATIONS; TRANSITION; PROTECTION; COMPLEXES; TOXICITY; PRODUCTS; POWDER AB An incoherent elastic neutron scattering study of the molecular dynamics of native human butyrylcholinesterase and its "aged" soman-inhibited conjugate revealed a significant change in molecular flexibility on an angstrom-nanosecond scale as a function of temperature. The results were related to the stability of each state as established previously by differential scanning calorimetry. A striking relationship was found between the denaturation behavior and the molecular flexibility of the native and inhibited enzymes as a function of temperature. This was reflected in a quantitative correlation between the atomic mean-square displacements on an angstrom-nanosecond scale determined by neutron spectroscopy and the calorimetric specific heat. By the application of a simple two-state model that describes the transition from a folded to a denatured state, the denaturation temperatures of the native and the inhibited enzyme were correctly extracted from the atomic mean-square displacements. Furthermore, the transition entropy and enthalpy extracted from the model fit of the neutron data were, within the experimental accuracy, compatible with the values determined by differential scanning calorimetry. C1 [Gabel, F.; Masson, P.; Zaccai, G.; Weik, M.] CEA CNRS UJF, Inst Biol Struct Jean Pierre Ebel, Lab Mol Biophys, Grenoble, France. [Froment, M. -T.] Serv Sante Armees, Ctr Rech, Unite Enzymol, La Tronche, France. [Doctor, B. P.; Saxena, A.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD USA. [Silman, I.] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel. [Zaccai, G.] Inst Max Von Laue Paul Langevin, F-38042 Grenoble, France. RP Gabel, F (reprint author), CEA CNRS UJF, Inst Biol Struct Jean Pierre Ebel, Lab Mol Biophys, Grenoble, France. EM frank.gabel@ibs.fr; martin.weik@ibs.fr RI Masson, Patrick/J-3964-2013 OI Masson, Patrick/0000-0002-7837-3662 FU European Union [HPRI-CT-2001-50035, RI13-CT-2003-505925]; Agence Nationale de la Recherche [JC05_45685] FX This study was supported by the European Union DLAB program under contract Nos. HPRI-CT-2001-50035 and RI13-CT-2003-505925. M.W. was supported by a grant from the Agence Nationale de la Recherche (project No. JC05_45685). NR 32 TC 7 Z9 7 U1 0 U2 3 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 EI 1542-0086 J9 BIOPHYS J JI Biophys. J. PD FEB 18 PY 2009 VL 96 IS 4 BP 1489 EP 1494 DI 10.1016/j.bpj.2008.10.029 PG 6 WC Biophysics SC Biophysics GA 450CE UT WOS:000266377800024 PM 19217865 ER PT J AU Peterson, GW Karwacki, CJ Feaver, WB Rossin, JA AF Peterson, Gregory W. Karwacki, Christopher J. Feaver, William B. Rossin, Joseph A. TI Zirconium Hydroxide as a Reactive Substrate for the Removal of Sulfur Dioxide SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID SO2 ADSORPTION; METAL-OXIDES; ACTIVATED CARBONS; TEMPERATURE; OXIDATION; CATALYST; COPPER; AIR; XPS AB Zirconium hydroxide [Zr(OH)(4)], with a surface area of 365 m(2)/g, was evaluated for its ability to remove SO(2) from streams of air at room temperature. The SO(2) removal capacity of Zr(OH)(4) was similar to 90 mg SO(2) removed per cm(3) bed volume, which is almost an order of magnitude greater than the value achieved for activated carbon and is more than twice the value achieved for activated carbon impregnated with 10% CuO. Temperature-programmed desorption results indicate that SO(2) is strongly retained by Zr(OH)(4). X-ray photoelectron spectroscopy results reveals the presence of sulfite (SO(3)(2-)) species following reaction exposure, which suggests the formation of zirconium sulfite. Although the SO(2) removal capacity (volume basis) of Zr(OH)(4) is high, relative to that of impregnated activated carbon, only 10% of the stoichiometric hydroxyl groups are able to contribute to the removal of SO(2). C1 [Feaver, William B.; Rossin, Joseph A.] Guild Associates Inc, Dublin, OH 43228 USA. [Peterson, Gregory W.; Karwacki, Christopher J.] USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Rossin, JA (reprint author), Guild Associates Inc, 5750 Shier Rings Rd, Dublin, OH 43228 USA. EM jarossin@guildassociates.com FU JSTO-CBD FX The authors wish to thank JSTO-CBD for their financial support. NR 21 TC 23 Z9 23 U1 1 U2 29 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD FEB 18 PY 2009 VL 48 IS 4 BP 1694 EP 1698 DI 10.1021/ie801403h PG 5 WC Engineering, Chemical SC Engineering GA 406BB UT WOS:000263268900002 ER PT J AU Lim, W Douglas, EA Kim, SH Norton, DP Pearton, SJ Ren, F Shen, H Chang, WH AF Lim, Wantae Douglas, E. A. Kim, S. -H. Norton, D. P. Pearton, S. J. Ren, F. Shen, H. Chang, W. H. TI High mobility InGaZnO4 thin-film transistors on paper SO APPLIED PHYSICS LETTERS LA English DT Article DE amorphous semiconductors; gallium compounds; indium compounds; lithography; paper; sputter deposition; thin film transistors ID PERFORMANCE; ARRAY AB We report on the fabrication and the electrical properties of amorphous (alpha-)InGaZnO4 thin-film transistors deposited on cellulose paper by sputtering at room temperature. The 150-mu m-thick paper was used as both a gate dielectric and a substrate for device structural support. The transistors on paper were patterned by lithography and operated in enhancement mode with a threshold voltage of 3.75 V, and exhibited saturation mobility, subthreshold gate-voltage swing, and drain current on-to-off ratio of similar to 35 cm(2) V-1 s(-1), 2.4 V decade(-1), and similar to 10(4), respectively. These results verify that simple cellulose paper is a good gate dielectric as well as a low-cost substrate for flexible electronic devices such as paper-based displays. C1 [Lim, Wantae; Douglas, E. A.; Kim, S. -H.; Norton, D. P.; Pearton, S. J.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Ren, F.] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. [Shen, H.; Chang, W. H.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Lim, W (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.ufl.edu RI Douglas, Erica/J-3732-2014 OI Douglas, Erica/0000-0003-1873-0223 FU Army Research Office [DAAD19-01-1-0603]; Army Research Laboratory; NSF [DMR 0700416] FX The work at UF was supported in part by the Army Research Office under Grant No. DAAD19-01-1-0603 (monitored by Dr. M. Gerhold) and the Army Research Laboratory and NSF (Grant No. DMR 0700416, Dr. L. Hess). We thank UFNF staff for their help in the performance of this work. NR 13 TC 54 Z9 56 U1 4 U2 23 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 16 PY 2009 VL 94 IS 7 AR 072103 DI 10.1063/1.3086394 PG 3 WC Physics, Applied SC Physics GA 410SS UT WOS:000263599200034 ER PT J AU Jacobson, IG Smith, TC Smith, B Keel, PK Amoroso, PJ Wells, TS Bathalon, GP Boyko, EJ Ryan, MAK AF Jacobson, Isabel G. Smith, Tyler C. Smith, Besa Keel, Pamela K. Amoroso, Paul J. Wells, Timothy S. Bathalon, Gaston P. Boyko, Edward J. Ryan, Margaret A. K. CA Millennium Cohort Study Team TI Disordered Eating and Weight Changes After Deployment: Longitudinal Assessment of a Large US Military Cohort SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE body weight changes; cohort studies; eating disorders; military medicine; military personnel ID POSTTRAUMATIC-STRESS-DISORDER; READJUSTMENT RATING-SCALE; MENTAL-HEALTH PROBLEMS; GULF-WAR VETERANS; MILLENNIUM COHORT; CONTRIBUTING FACTORS; CAGE QUESTIONNAIRE; BULIMIA-NERVOSA; ALCOHOL-USE; PREVALENCE AB The effect of military deployments to combat environments on disordered eating and weight changes is unknown. Using longitudinal data from Millennium Cohort Study participants who completed baseline (2001-2003) and follow-up (2004-2006) questionnaires (n = 48,378), the authors investigated new-onset disordered eating and weight changes in a large military cohort. Multivariable logistic regression was used to compare these outcomes among those who deployed and reported combat exposures, those who deployed but did not report combat exposures, and those who did not deploy in support of the wars in Iraq and Afghanistan. Deployment was not significantly associated with new-onset disordered eating in women or men, after adjustment for baseline demographic, military, and behavioral characteristics. However, in subgroup comparison analyses of deployers, deployed women reporting combat exposures were 1.78 times more likely to report new-onset disordered eating (95% confidence interval: 1.02, 3.11) and 2.35 times more likely to lose 10% or more of their body weight compared with women who deployed but did not report combat exposures (95% confidence interval: 1.17, 4.70). Despite no significant overall association between deployment and disordered eating and weight changes, deployed women reporting combat exposures represent a subgroup at higher risk for developing eating problems and weight loss. C1 [Jacobson, Isabel G.; Smith, Tyler C.; Smith, Besa; Ryan, Margaret A. K.] USN, Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, San Diego, CA 92106 USA. [Keel, Pamela K.] Florida State Univ, Dept Psychol, Tallahassee, FL 32306 USA. [Amoroso, Paul J.] Madigan Army Med Ctr, Ft Lewis, WA USA. [Wells, Timothy S.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Bathalon, Gaston P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. RP Jacobson, IG (reprint author), USN, Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, 140 Sylvester Rd, San Diego, CA 92106 USA. EM isabel.jacobson@med.navy.mil FU Military Operational Medicine Research Program of the US Army Medical Research; Materiel Command, Fort Dietrick, Maryland FX The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the US Army Medical Research and Materiel Command, Fort Dietrick, Maryland. NR 55 TC 43 Z9 44 U1 2 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD FEB 15 PY 2009 VL 169 IS 4 BP 415 EP 427 DI 10.1093/aje/kwn366 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 407ZR UT WOS:000263403300005 PM 19193718 ER PT J AU Van Dam, CN Syed, S Eron, JJ Ostrander, M Engler, RJM Damon, I Montgomery, JR Tong, SX Adimora, AA Kahn, KA Ruone, S Anderson, L Weber, DJ AF Van Dam, Cornelius N. Syed, Samina Eron, Joseph J. Ostrander, Matthew Engler, Renata J. M. Damon, Inger Montgomery, Jay R. Tong, Suxiang Adimora, Adaora A. Kahn, Kevin A. Ruone, Susan Anderson, Larry Weber, David J. TI Severe Postvaccinia Encephalitis with Acute Disseminated Encephalomyelitis: Recovery with Early Intravenous Immunoglobulin, High-Dose Steroids, and Vaccinia Immunoglobulin SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID SMALLPOX VACCINATION AB We report the second case of severe postvaccinial encephalitis with acute disseminated encephalomyelitis since smallpox vaccination was reintroduced in 2002. Both affected patients responded dramatically with early intervention of intravenous immunoglobulin. Our patient, who also received concurrent vaccinia immunoglobulin and corticosteroids, demonstrated full recovery. C1 [Van Dam, Cornelius N.] Univ N Carolina, AHEC, Moses Cone Hosp, Dept Internal Med Infect Dis, Greensboro, NC 27401 USA. [Eron, Joseph J.; Adimora, Adaora A.; Weber, David J.] Univ N Carolina, Dept Med, Div Infect Dis, Chapel Hill, NC USA. [Ostrander, Matthew; Kahn, Kevin A.] Univ N Carolina, Dept Neurol, Chapel Hill, NC USA. [Syed, Samina] Univ Illinois, Dept Internal Med, Chicago, IL USA. [Engler, Renata J. M.; Montgomery, Jay R.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Washington, DC 20307 USA. [Engler, Renata J. M.; Montgomery, Jay R.] Walter Reed Army Med Ctr, Allergy Immunol Dept, Washington, DC 20307 USA. [Damon, Inger] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA USA. [Tong, Suxiang; Ruone, Susan; Anderson, Larry] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. RP Van Dam, CN (reprint author), Univ N Carolina, AHEC, Moses Cone Hosp, Dept Internal Med Infect Dis, 1200 N Elm St, Greensboro, NC 27401 USA. EM kvandam@med.unc.edu FU University of North Carolina at Chapel Hill FX Financial support. University of North Carolina at Chapel Hill. NR 9 TC 6 Z9 6 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD FEB 15 PY 2009 VL 48 IS 4 BP E47 EP E49 DI 10.1086/596553 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 396IP UT WOS:000262585700028 PM 19133803 ER PT J AU Chia, VM Li, Y Goldin, LR Graubard, BI Greene, MH Korde, L Rubertone, MV Erickson, RL McGlynn, KA AF Chia, Victoria M. Li, Yan Goldin, Lynn R. Graubard, Barry I. Greene, Mark H. Korde, Larissa Rubertone, Mark V. Erickson, Ralph L. McGlynn, Katherine A. TI Risk of cancer in first- and second-degree relatives of testicular germ cell tumor cases and controls SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article DE testicular cancer; family; aggregation ID FAMILY-HISTORY; POPULATION; BREAST; EPIDEMIOLOGY; BROTHERS; SWEDEN; TRENDS AB Risk factors for testicular germ cell tumors (TGCT) have not been well identified; however, data suggest that risks of cancer in family members or men with TGCT is elevated. Using family history data from 738 cases and 904 controls enrolled in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) Study from 2002 to 2005, the risk of cancer in first- and second-degree faimly members of these men was examined. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusting for reference age of case or control, race/ethnicity of case or control, sex of family member and lineage (maternal vs. paternal). An increased risk of all cancer among first-degree relatives of cases compared to controls was observed (RR = 1.17, 95% CI: 1.01-1.35). There were suggestions of differences in risk when stratifying all relatives by lineage. For maternal relatives, there was a statistically significant increased risk of all cancer (RR = 1.16, 95% CI: 1.04 1.30), digestive tract (RR 1.52, 95% CI: 1.15-2.00) and male genital organ cancer (RR 1.70, 95% CI: 1.15-2.51). there was also a suggestion of increased risks of hematopoetic cancers, cancers in the female genital organs and nonmelanoma skin cancer. For paternal relatives, there was a statistically significant association only with decreased risk of lung cancer (RR = 0.69, 95% CI: 0.51-0.0). Thus, this study suggests that there may be aggregation of cancer among families of men diagnosed with TGCT. C1 [Chia, Victoria M.] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Army Med Surveillance Act, Washington, DC 20310 USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, GEIS, Div Prevent Med, Silver Spring, MD USA. RP Chia, VM (reprint author), NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, EPS Suite 550,6120 Execut Blvd, Bethesda, MD 20892 USA. EM chiav@mail.nih.gov FU Intramural NIH HHS [Z01 CP010126-12, NIH0013310441] NR 29 TC 10 Z9 10 U1 0 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0020-7136 J9 INT J CANCER JI Int. J. Cancer PD FEB 15 PY 2009 VL 124 IS 4 BP 952 EP 957 DI 10.1002/ijc.23971 PG 6 WC Oncology SC Oncology GA 396VD UT WOS:000262618400026 PM 19035442 ER PT J AU Brevett, CAS Sumpter, KB Nickol, RG AF Brevett, Carol A. S. Sumpter, Kenneth B. Nickol, Robert G. TI Kinetics of the degradation of sulfur mustard on ambient and moist concrete SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Sulfur mustard; H-2TG; Sulfonium ion; HD; (13)C SSMAS NMR ID CHEMICAL WARFARE; BIS(2-CHLOROETHYL) SULFIDE; 2-CHLOROETHYL SULFIDES; IMPREGNATED CARBONS; HD; VX; AGENTS; GAS; NMR; GD AB The rate of degradation of the chemical warfare agent sulfur mustard, bis(2-chloroethyl) sulfide, was measured on ambient and moist concrete using (13)C Solid State Magic Angle Spinning Nuclear Magnetic Resonance (SSMAS NMR). Three samples of concrete made by the same formulation, but differing in age and alkalinity were used. The sulfur mustard eventually degraded to thiodiglycol and 1,4-oxathiane via the intermediate sulfonium ions CH-TG, H-TG, H-2TG and O(CH(2)CH(2))(2)S(+)CH(2)CH(2)OH on all of the concrete samples, and in addition formed 8-31% vinyl moieties on the newer, more alkaline concrete samples. This is the first observation of the formation of O(CH(2)CH(2))(2)S(+)CH(2)CH(2)OH on a solid substrate. The addition of 2-chloroethanol to concrete on which mustard had fully degraded to thiodiglycol and 1,4-oxathiane resulted in the formation of O(CH(2)CH(2))(2)S(+)CH(2)CH(2)OH, thus demonstrating the reversibility of sulfur mustard degradation pathways. The sulfur mustard degradation half-lives on ambient concrete at 22 degrees C ranged from 3.5 to 54 weeks. When the substrates were moistened, the degradation half-lives at 22 degrees C ranged from 75 to 350 h. The degradation of sulfur mustard occurred more quickly at elevated temperatures and with added water. The non-volatile toxic sulfonium ions persisted for months to years on concrete at 22 degrees C and weeks to months on concrete at 35 degrees C, before decomposing to the relatively non-toxic compounds thiodiglycol and 1,4-oxathiane. (C) 2008 Elsevier B.V. All rights reserved. C1 [Brevett, Carol A. S.; Nickol, Robert G.] SAIC, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. [Sumpter, Kenneth B.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Brevett, CAS (reprint author), SAIC, Gunpowder Branch, POB 68, Aberdeen Proving Ground, MD 21010 USA. EM carol.brevett@us.army.mil FU SAIC [DAAD13-03-D-0017] FX The authors thank Drs. James Savage, H. Dupont Durst and Mark Brickhouse for programmatic support, Dr. George Wagner for stimulating discussions, and Mr. David Sorrick for the supply of 13C-labeled sulfur mustard (U.S. Army Research, Development and Engineering Command, Aberdeen Proving Ground, MD). The authors acknowledge Ms. Christine Franklin (SAIC) for administrative support, Mr. Carroll Cook (SAIC) for assistance with the agent operations, Mr. Dennis Bevilacqua (SAIC) for instrumentation support, Mr. Richard Smith (U.S. Air Force Civil Engineering Support Agency, Tyndall, FL) for the aged concrete sample; and Dr. C. Weiss (U.S.Army Engineering R&D Center, Vicksburg, MS)for the concrete, mortar and limestone samples. The work described in this report was performed under SAIC Contract No DAAD13-03-D-0017. NR 35 TC 12 Z9 12 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD FEB 15 PY 2009 VL 162 IS 1 BP 281 EP 291 DI 10.1016/j.jhazmat.2008.05.033 PG 11 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 404KC UT WOS:000263149400035 PM 18584953 ER PT J AU Nadavala, SK Swayampakula, K Boddu, VM Abburi, K AF Nadavala, Siva Kumar Swayampakula, Kalyani Boddu, Veere M. Abburi, Krishnaiah TI Biosorption of phenol and o-chlorophenol from aqueous solutions on to chitosan-calcium alginate blended beads SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Biosorption; Chitosan-alginate blended beads; o-Chlorophenol; Phenol ID ACTIVATED CARBON; ADSORPTION; REMOVAL; WATER; SORBENT; RELEASE; CHITIN; RESIN AB Beads of chitosan-sodium alginate are prepared from naturally occurring biopolymers, chitosan (a cationic polysaccharide) and sodium alginate (an anionic polysaccharide). These beads are treated with CaCl(2) in order to improve the stability as well as the sorption capacity of the biosorbent. The resulting chitosan-alginate beads are characterized by BET surface area analysis, Fourier transformer infrared spectroscopy (FTIR) and wide-angle X-ray diffraction (WXRD) techniques. The efficiency of the biosorbent is studied by measuring the uptake using the equilibrium batch technique and breakthrough curves obtained from column flow experiments. The effect of pH, contact time, initial concentration of adsorbate and amount of biosorbent on adsorption capacity of the biosorbent is investigated. The equilibrium adsorption data are fitted to first-order and second-order kinetic equations, and to Weber-Morris model. The Freundlich, Langmuir and Dubinin-Radushkevich (D-R) adsorption isotherm models are used for the description of the biosorption process. Further, column break-through curves are obtained and the sorbent loaded with phenol and o-chlorophenol is regenerated using 0.1 M NaOH solution. The experimental results suggest that the chitosan-calcium alginate blended biosorbent is effective for the removal of phenol and o-chlorophenol from an aqueous medium. (c) 2008 Elsevier B.V. All rights reserved. C1 [Nadavala, Siva Kumar; Swayampakula, Kalyani; Abburi, Krishnaiah] Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Labs, Tirupati 517502, Andhra Pradesh, India. [Boddu, Veere M.] Engn Res & Dev Ctr CERL, Champaign, IL 61826 USA. RP Abburi, K (reprint author), Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Labs, Tirupati 517502, Andhra Pradesh, India. EM abburikrishnaiah@gmail.com RI Dr., Nadavala Siva Kumar /D-5404-2011; swayampakula, kalyani/D-6233-2011 OI Dr., Nadavala Siva Kumar /0000-0003-3210-8254; NR 37 TC 72 Z9 76 U1 4 U2 38 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD FEB 15 PY 2009 VL 162 IS 1 BP 482 EP 489 DI 10.1016/j.jhazmat.2008.05.070 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 404KC UT WOS:000263149400063 PM 18573601 ER PT J AU Buchireddy, PR Bricka, RM Gent, DB AF Buchireddy, Prashanth R. Bricka, R. Mark Gent, David B. TI Electrokinetic remediation of wood preservative contaminated soil containing copper, chromium, and arsenic SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Electrokinetics; Copper; Chromium; Arsenic; Soil; CCA; Remediation; Treatment; Contaminant removal; Metals treatment; Electrochemical ID CONDITIONING CATHOLYTE PH; HEAVY-METALS; ELECTRODIALYTIC REMEDIATION; RED SOIL; REMOVAL; LEAD; CADMIUM; EXTRACTION; SCALE; CLAY AB As a result of wood treatment, and the recent banning of the copper, chromium, and arsenic (CCA) treated wood for residential use many CCA treatment facilities have been abandoned or being closed. Soil contamination resulting from CCA is common at these sites. In this study, the feasibility of electrokinetic technique to remove CCA from contaminated soil was investigated. To better understand the ionic mobility within the soil and to detect the generation and advancement of acid front. sampling ports were provided along the longitudinal axis of a test cell. To determine the effect of varying current. three tests were performed at different current densities of 5.9, 2.9, and 1.5 mA/cm(2) for a period of 15 days. The initial concentrations of copper, chromium, and arsenic in the soil were 4800, 3100, and 5200 mg/kg, respectively. Dilute nitric acid was used as an amendment to neutralize the hydroxyl ions produced at the cathode. Experiments resulted in removal efficiencies as high as 65% for copper, 72% for chromium, and 77% for arsenic. The results also indicated that the advancement of acid front favored desorption of metals from the soil and the metals were mobilized either as free cations or metal complexes. Chromium that was in its +6 valence state was transported as anion prior to its reduction. However, once the chromium was reduced to chromium(III) its transport direction reversed with transport being favored towards the cathode. (c) 2008 Elsevier B.V. All rights reserved. C1 [Buchireddy, Prashanth R.; Bricka, R. Mark] Mississippi State Univ, Dave C Swalm Sch Chem Engn, Mississippi State, MS 39762 USA. [Gent, David B.] US ACE Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Bricka, RM (reprint author), Mississippi State Univ, Dave C Swalm Sch Chem Engn, Mississippi State, MS 39762 USA. EM bricka@che.msstate.edu FU Research Initiation Program; Mississippi State University FX This work was supported by the Research Initiation Program, Office of Research at Mississippi State University. The authors would like to thank Mr. Chris Fetters for his technical input and assistance designing experimental set up. Also, the authors would like to acknowledge Mr. Brad Hensarling, Mr. Anirudha Marwaha, and Mr. Monty Singletary for providing laboratory assistance. NR 42 TC 21 Z9 24 U1 4 U2 42 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD FEB 15 PY 2009 VL 162 IS 1 BP 490 EP 497 DI 10.1016/j.jhazmat.2008.05.092 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 404KC UT WOS:000263149400064 PM 18599200 ER PT J AU Paredes, R Sagar, M Marconi, VC Hoh, R Martin, JN Parkin, NT Petropoulos, CJ Deeks, SG Kuritzkes, DR AF Paredes, Roger Sagar, Manish Marconi, Vincent C. Hoh, Rebecca Martin, Jeffrey N. Parkin, Neil T. Petropoulos, Christos J. Deeks, Steven G. Kuritzkes, Daniel R. TI In Vivo Fitness Cost of the M184V Mutation in Multidrug-Resistant Human Immunodeficiency Virus Type 1 in the Absence of Lamivudine SO JOURNAL OF VIROLOGY LA English DT Article ID CYTOTOXIC T-LYMPHOCYTES; HIV-1 INFECTION; REVERSE-TRANSCRIPTASE; RELATIVE FITNESS; THERAPY; RECOMBINATION; INTERRUPTION; RECOGNITION; EVOLUTION; VARIANTS AB Lamivudine therapy selects for the M184V mutation. Although this mutation reduces the replicative capacity of human immunodeficiency virus in vitro, its impact on viral fitness in vivo has not been well defined. We used quantitative allele-specific PCR to precisely calculate the fitness differences between the mutated M184V virus and one that had reverted to the wild type in a cohort of patients by selectively interrupting reverse transcriptase inhibitor therapy, and we found that the M184V variants were consistently 4 to 8% less fit than the wild type in the absence of drug. After a lag phase of variable duration, wild-type variants emerged due to continued evolution of pol and back mutation rather than through emergence of an archived wild-type variant. C1 [Paredes, Roger; Sagar, Manish; Marconi, Vincent C.; Kuritzkes, Daniel R.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Sect Retroviral Therapeut, Cambridge, MA 02139 USA. [Paredes, Roger] Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Fdn IrsiCaixa & Lluita SIDA, Badalona, Catalonia, Spain. [Marconi, Vincent C.] San Antonio Mil Med Ctr, Brooke Army Med Ctr, Infect Dis Serv, San Antonio, TX USA. [Hoh, Rebecca; Martin, Jeffrey N.; Deeks, Steven G.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Hoh, Rebecca; Martin, Jeffrey N.; Deeks, Steven G.] San Francisco Gen Hosp, San Francisco, CA 94110 USA. [Parkin, Neil T.; Petropoulos, Christos J.] Monogram Biosci Inc, San Francisco, CA USA. RP Kuritzkes, DR (reprint author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Sect Retroviral Therapeut, 65 Landsdowne St,Rm 449, Cambridge, MA 02139 USA. EM dkuritzkes@partners.org RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Sagar, Manish/0000-0001-9803-6594 FU National Institutes of Health [R01 AI42567, R01 AI052745, R37 AI055357, K24 RR16482]; Adult ACTG [U01 AI068636]; Harvard Medical School Center for AIDS Research Virology Core [P30 AI060354]; UCSF/Gladstone CFAR [P30 MH59037]; UCSF Clinical and Translational Science Institute [UL1 RR024131-01]; La Caixa Fellowship Grant; Caixa d'Estalvis i Pensions de Barcelona, La Caixa, Barcelona, Catalonia, Spain FX This work was supported in part by the following: U.S. Public Health Service grants from the National Institutes of Health (R01 AI42567, R01 AI052745, R37 AI055357, K24 RR16482), a Virology Support Laboratory contract from the Adult ACTG (U01 AI068636), a grant from the Harvard Medical School Center for AIDS Research Virology Core (P30 AI060354) to D. R. K, and grants from the UCSF/Gladstone CFAR (P30 MH59037) and the UCSF Clinical and Translational Science Institute (UL1 RR024131-01) to S. G. D. Roger Paredes received the La Caixa Fellowship Grant for Post-Graduate Studies, Caixa d'Estalvis i Pensions de Barcelona, La Caixa, Barcelona, Catalonia, Spain. NR 21 TC 49 Z9 51 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD FEB 15 PY 2009 VL 83 IS 4 BP 2038 EP 2043 DI 10.1128/JVI.02154-08 PG 6 WC Virology SC Virology GA 400AK UT WOS:000262840200051 PM 19019971 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Hitler's Pro-Emptive War: The Battle for Norway, 1940 SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD FEB 15 PY 2009 VL 134 IS 3 BP 116 EP 116 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 411GI UT WOS:000263636900153 ER PT J AU Dmitriev, AE Lehman, RA Helgeson, MD Sasso, RC Kuhns, C Riew, DK AF Dmitriev, Anton E. Lehman, Ronald A., Jr. Helgeson, Melvin D. Sasso, Rick C. Kuhns, Craig Riew, Daniel K. TI Acute and Long-term Stability of Atlantoaxial Fixation Methods A Biomechanical Comparison of Pars, Pedicle, and Intralaminar Fixation in an Intact and Odontoid Fracture Model SO SPINE LA English DT Article DE intralaminar screw; atlantoaxial fixation; axis; biomechanics; atlantoaxial instability; transpedicular fixation ID TRANSARTICULAR SCREW FIXATION; C1-C2 FUSION; CERVICAL-SPINE; TECHNICAL NOTE; C2 PEDICLE; ARTHRODESIS AB Study Design. In vitro human cadaveric biomechanical study. Objective. The aims of this project were to evaluate the acute segmental fixation and long-term screw stability afforded by 3 C2 fixation techniques: intralaminar, pars, and pedicle. Summary of Background Data. C2 intralaminar screws offer the advantages of avoiding the vertebral artery; however, direct biomechanical comparison of this technique to the other methods of instrumenting C2 has not been performed. Methods. Fourteen cadaveric specimens were dual energy radiograph absorptiometry scanned and segregated into 2 groups (n = 7/group) matching the C2 bone mineral density. All specimens were instrumented with C1 lateral mass and C2 intralaminar screws while measuring the insertional torque (IT). In group 1 C2 pars screws were inserted while in group 2 pedicle screws were placed. Nondestructive testing was performed in axial rotation, flexion/extension (FE), and lateral bending. The odontoid was then resected and loading repeated. Subsequently, specimens were disarticulated about C2 and individually loaded for 2000 cycles in the cephalocaudad plane. The screws were then failed by a tensile load directed in the parasagittal plane. Full range of motion over C1-C2 and peak screw pull-out force was quantified. Results. Transpedicular technique generated significantly higher IT than the pars screws and marginally greater IT than intralaminar screws. With the intact atlantoaxial ligamentous complex, intralaminar fixation was superior to pars and similar to pedicle instrumentation at limiting axial torsion. After odontoid destabilization, however, this technique was less effective at reducing the lateral bending range of motion. Destructive loading revealed the highest pull-out forces with the pedicle screws, followed by intralaminar and pars screws. Conclusion. Our results suggest that C2 intralaminar fixation provides a viable alternative to pedicle screws and is superior to pars instrumentation in cases with preserved atlantoaxial ligamentous attachments. In the presence of a traumatic dens fracture, however, intralaminar fixation may not be the optimal choice. C1 [Dmitriev, Anton E.] Walter Reed Army Med Ctr, Spine Res Lab, Dept Orthopaed & Rehabil, Washington, DC 20012 USA. [Sasso, Rick C.] Univ Indianapolis, Sch Med, Indiana Spine Grp, Indianapolis, IN 46227 USA. [Kuhns, Craig] Univ Missouri, Columbia, MO USA. [Riew, Daniel K.] Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA. RP Dmitriev, AE (reprint author), Walter Reed Army Med Ctr, Spine Res Lab, Dept Orthopaed & Rehabil, POB 59037, Washington, DC 20012 USA. EM aedortho@gmail.com NR 19 TC 20 Z9 25 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD FEB 15 PY 2009 VL 34 IS 4 BP 365 EP 370 DI 10.1097/BRS.0b013e3181976aa9 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 409PH UT WOS:000263517800010 PM 19214095 ER PT J AU Nersisyan, HH Il Won, H Won, CW Cho, KC AF Nersisyan, Hayk H. Il Won, Hyung Won, Chang Whan Cho, Kyu C. TI Combustion synthesis of nanostructured tungsten and its morphological study SO POWDER TECHNOLOGY LA English DT Article DE Tungsten nanopowder; Combustion synthesis; Particle size; Oxygen; Zinc ID NANOCRYSTALLINE; ALLOYS AB A tungsten trioxide, zinc, and sodium chloride (WO(3)+3Zn+kNaCl) mixture was used as a precursor material for the manufacture of tungsten (W) nanopowders. Precursor material components were dry mixed and heated up to 450 degrees C under a constant argon gas flow to promote a combustion reaction. Combustion products were subjected to acid enrichment followed by isothermal heat treatment under hydrogen flow at temperatures ranging from 650 to 850 degrees C to reduce oxygen concentration. As-synthesized W nanopowders were characterized with respect to average particle size, particle size distribution, oxygen concentration, and phases. Under optimized reaction conditions, W particles with diameters less than 100 nm and an average interstitial oxygen concentration lower than 1.0 wt.% were obtained. (C) 2008 Elsevier B.V. All rights reserved. C1 [Nersisyan, Hayk H.; Il Won, Hyung; Won, Chang Whan] Chungnam Natl Univ, Rapidly Solidified Mat Res Ctr RASOM, Taejon 305764, South Korea. [Cho, Kyu C.] USA, Res Lab, Weap & Mat Res Directorate, APG, Aberdeen Proving Ground, MD 21005 USA. RP Nersisyan, HH (reprint author), Chungnam Natl Univ, Rapidly Solidified Mat Res Ctr RASOM, Taejon 305764, South Korea. EM haykrasom@hotmail.com NR 11 TC 20 Z9 20 U1 1 U2 4 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0032-5910 J9 POWDER TECHNOL JI Powder Technol. PD FEB 13 PY 2009 VL 189 IS 3 BP 422 EP 425 DI 10.1016/j.powtec.2008.07.002 PG 4 WC Engineering, Chemical SC Engineering GA 416MQ UT WOS:000264010600006 ER PT J AU O'Malley, PG AF O'Malley, Patrick G. TI Cost-effective Primary Care-Based Strategies to Improve Smoking Cessation More Value for Money INVITED COMMENTARY SO ARCHIVES OF INTERNAL MEDICINE LA English DT Editorial Material C1 Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Bethesda, MD 20814 USA. RP O'Malley, PG (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Bethesda, MD 20814 USA. EM pomalley@usuhs.mil NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD FEB 9 PY 2009 VL 169 IS 3 BP 235 EP 236 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 405DK UT WOS:000263202600004 ER PT J AU Bromberg, L Schreuder-Gibson, H Creasy, WR McGarvey, DJ Fry, RA Hatton, TA AF Bromberg, Lev Schreuder-Gibson, Heidi Creasy, William R. McGarvey, David J. Fry, Roderick A. Hatton, T. Alan TI Degradation of Chemical Warfare Agents by Reactive Polymers SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID ISOPROPYL METHYLPHOSPHONOFLUORIDATE SARIN; HYDROXAMIC ACIDS; NMR-SPECTROSCOPY; POLY(HYDROXAMIC ACID); CATALYTIC HYDROLYSIS; NITROPHENYL ACETATE; FUNCTIONAL-GROUPS; AMIDOXIME FIBER; NERVE AGENTS; VX AB Nucleophilic hydrolysis of chemical warfare agents (CWA), S-2-(diisopropylamino)ethyl O-ethyl methylphosphonothioate (VX), O-pinacolyl methylphosphonofluoridate (soman, or GD), and isopropyl methylphosphonofluoridate (sarin, or GB) by polyacrylamidoxime (PANOx) and poly(N-hydroxyacrylanmide) (PHA) has been demonstrated. The reactive PANOx and PHA were obtained by one-step oximation of polyacrylonitrile and polyacrylamide, respectively. The polymers were converted to their respective oximate salts at pH values greater than the pK(a) of oximate or amidoximate groups of 7.5 and 10.8, respectively. Although the PANOx and PHA exhibited spontaneous hydrolysis at ambient temperature and humidity, the conversion of the hydroxamate into the unreactive carboxylic groups was insignificant even at prolonged storage, so that the polymers maintained reactivity at ambient conditions. When exposed to ambient air or 100% humidity, the polymers imbibed up to 65 wt % water, which dramatically enhanced the polymer reactivity toward the CWA under study. The half-lives of VX in heterogeneous hydrolysis, which appeared to be pseudo-first-order in the polymer dispersions, were measured to be from 0.093 to 4.3 and 7.7 h in the presence of PANOx and PHA, respectively. The rates of hydrolytic activity of PANOx for VX exhibited a strong dependency on the degree of conversion of the amidoxime to amidoximate groups. The half-life of GB was less than 3 min. Only a minor presence of the toxic VX degradation product, S-[2-(diisopropylamino)ethyl]methylphonothioate (EA-2192), was detected in the course of degradation by the reactive polymers. The efficiency, ease of synthesis, and nontoxic nature of the PANOx and PHA polymers make them attractive materials in decontamination and as components of reactive barriers. C1 [Bromberg, Lev; Hatton, T. Alan] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Schreuder-Gibson, Heidi] US Army Natick Soldier Res, Ctr Dev & Engn, Macromol Sci Team, Natick, MA 01760 USA. [Creasy, William R.; Fry, Roderick A.] Sci Applicat Int Corp, Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [McGarvey, David J.] USA, Edgewood Chem & Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Hatton, TA (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA. EM tahatton@mit.edu FU Department of the Army, U.S. Army Research Office [W911NF-07-1-0139]; Defense Threat Reduction Agency [BAO7PRO102] FX L.B. and T.A.H. acknowledge sponsorship by the Department of the Army, U.S. Army Research Office, under Grant W911NF-07-1-0139. NSRDEC and SAIC teams were supported via Defense Threat Reduction Agency Project BAO7PRO102. W.R.C., D.J.M., and R.A.F. are grateful to Dr. H. Dupont burst (Edgewood Chemical and Biological Center) for his support. NR 62 TC 37 Z9 37 U1 3 U2 35 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD FEB 4 PY 2009 VL 48 IS 3 BP 1650 EP 1659 DI 10.1021/ie801150y PG 10 WC Engineering, Chemical SC Engineering GA 400TY UT WOS:000262892800079 ER PT J AU Wang, CC Trivedi, S Jin, F Swaminathan, V Rodriguez, P Prasad, NS AF Wang, Chen-Chia Trivedi, Sudhir Jin, Feng Swaminathan, V. Rodriguez, Ponciano Prasad, Narasimha S. TI High sensitivity pulsed laser vibrometer and its application as a laser microphone SO APPLIED PHYSICS LETTERS LA English DT Article DE diaphragms; measurement by laser beam; microphones; rough surfaces; vibration measurement AB We experimentally demonstrate a high sensitivity pulsed laser vibrometer that is capable of detecting optically rough surfaces vibrating with the displacement value of 75 pm as well as its application as a laser microphone. By directing the probe light beam repeatedly onto the vibrating diaphragm and/or pressure sensing interface, the sensitivity of the pulsed laser vibrometer in detecting the displacement of the vibrating diaphragm is significantly improved down to an estimated value of less than 4 pm In this paper, we present the principles of operation of this new kind of laser microphone together with experimental validations. C1 [Wang, Chen-Chia; Trivedi, Sudhir; Jin, Feng] Brimrose Corp Amer, Baltimore, MD 21236 USA. [Swaminathan, V.] USA, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. [Rodriguez, Ponciano] INAOE, Puebla 7200, Mexico. [Prasad, Narasimha S.] NASA, Langley Res Ctr, Hampton, VA 23681 USA. RP Wang, CC (reprint author), Brimrose Corp Amer, 7720 Belair Rd, Baltimore, MD 21236 USA. EM ccwang@brimrose.com FU U. S. Army ARDEC [W15QKN-07-P0546]; U. S. Army RDECOM CERDEC NVESD [W15P7T-O6-CF004] FX The authors acknowledge the partial financial support by U. S. Army ARDEC under Contract No. W15QKN-07-P0546 and U. S. Army RDECOM CERDEC NVESD through a SBIR Phase II contract (Contract No. W15P7T-O6-CF004). We also thank Brad Libbey and James Habersat of U. S. Army Nightvision Laboratory for their insightful guidance and comments that contributed to the foundation of our work. NR 9 TC 8 Z9 8 U1 0 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 2 PY 2009 VL 94 IS 5 AR 051112 DI 10.1063/1.3078520 PG 3 WC Physics, Applied SC Physics GA 404QB UT WOS:000263167000012 ER PT J AU Cole, B Goldberg, L Trussell, CW Hays, A Schilling, BW McIntosh, C AF Cole, Brian Goldberg, Lew Trussell, C. Ward Hays, Alan Schilling, Bradley W. McIntosh, Chris TI Reduction of timing jitter in a Q-Switched Nd:YAG laser by direct bleaching of a Cr4+:YAG saturable absorber SO OPTICS EXPRESS LA English DT Article ID ABSORPTION AB A method for optical triggering of a Q-switched Nd:YAG laser by direct bleaching of a Cr:YAG saturable absorber is described. This method involves the bleaching of a thin sheet of the saturable absorber from a direction orthogonal to the lasing axis using a single laser diode bar, where the Cr:YAG transmission increased from a non-bleached value of 47% to a bleached value of 63%. For steady state operation of a passively Q-switched laser (PRF=10Hz), the pulse-to-pulse timing jitter showed similar to 12X reduction in standard deviation, from 241 nsec for free running operation to 20 nsec with optical triggering. (C) 2009 Optical Society of America C1 [Cole, Brian; Goldberg, Lew; Trussell, C. Ward; Hays, Alan; Schilling, Bradley W.; McIntosh, Chris] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Cole, B (reprint author), USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 9 TC 33 Z9 34 U1 4 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD FEB 2 PY 2009 VL 17 IS 3 BP 1766 EP 1771 DI 10.1364/OE.17.001766 PG 6 WC Optics SC Optics GA 408JX UT WOS:000263432400065 PM 19189006 ER PT J AU Nersisyan, SR Tabiryan, NV Hoke, L Steeves, DM Kimball, B AF Nersisyan, Sarik R. Tabiryan, Nelson V. Hoke, Landa Steeves, Diane M. Kimball, Brian TI Polarization insensitive imaging through polarization gratings SO OPTICS EXPRESS LA English DT Article ID LIQUID-CRYSTAL; PROJECTION DISPLAYS; LIGHT SOURCE; AZOBENZENE; BANDGAP AB Liquid crystal polarization gratings exhibit high diffraction efficiency (similar to 100%) in thin material layers comparable to the radiation wavelength. We demonstrate that they can be combined for polarization-insensitive imaging and optical switching applications. A pair of closely spaced, parallel oriented, cycloidal polarization gratings is capable of canceling the diffractive property of an individual grating. As a result, the phase of the beam is not distorted, and holographic images can be formed through them. An anti-parallel arrangement results in a broader effective diffraction band and doubles the diffraction angle. Broadband diffraction spanning from 480 nm to beyond 900 nm wavelengths has been obtained for a pair of gratings with 500 nm and 633 nm peak diffraction wavelengths. Liquid crystal polymer cycloidal gratings were used in the study showing 98% diffraction efficiency over a large area, and allowed for the use of laser beams expanded to 25 mm. The characteristics of combined cycloidal gratings were tested with laser beams at both UV and red wavelengths. (C) 2009 Optical Society of America C1 [Hoke, Landa; Steeves, Diane M.; Kimball, Brian] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Nersisyan, Sarik R.; Tabiryan, Nelson V.] BEAM Engn Adv Measurements Co, Winter Pk, FL 32789 USA. RP Kimball, B (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, Kansas St, Natick, MA 01760 USA. EM brian.r.kimball@us.army.mil NR 29 TC 35 Z9 35 U1 2 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD FEB 2 PY 2009 VL 17 IS 3 BP 1817 EP 1830 DI 10.1364/OE.17.001817 PG 14 WC Optics SC Optics GA 408JX UT WOS:000263432400071 PM 19189012 ER PT J AU Wu, JR Moser, DK De Jong, MJ Rayens, MK Chung, ML Riegel, B Lennie, TA AF Wu, Jia-Rong Moser, Debra K. De Jong, Marla J. Rayens, Mary Kay Chung, Misook L. Riegel, Barbara Lennie, Terry A. TI Defining an evidence-based cutpoint for medication adherence in heart failure SO AMERICAN HEART JOURNAL LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; ACUTE MYOCARDIAL-INFARCTION; HEALTH-CARE COSTS; QUALITY-OF-LIFE; ELDERLY-PATIENTS; REFILL ADHERENCE; STATIN THERAPY; PREDICTORS; INTERVENTION; NONADHERENCE AB Background Despite the importance of medication adherence in heart failure, clinically relevant cutpoints for distinguishing the level of adherence associated with outcomes are unknown. Objective The purpose of this study is to determine the cutpoint above which there is a positive relationship between level of medication adherence and event-free survival. Methods This was a longitudinal study of 135 patients with heart failure. Medication adherence was measured using a valid and objective measure, the Medication Event Monitoring System. Two indicators of adherence were assessed by the Medication Event Monitoring System (AARDEX, Union City, CA): (1) dose count, percentage of prescribed doses taken, and (2) dose days, percentage of days the correct number of doses was taken. Patients were followed up to 3.5 years to collect data on outcomes. A series of Kaplan-Meier plots with log-rank tests, Cox survival analyses, and receiver operating characteristic curves were assessed comparing event-free survival in patients divided at one-point incremental cutpoints. Results Event-free survival was significantly better when the prescribed number of doses taken (dose count) or the correct dose (dose day) was >= 88%. This level was confirmed in a Cox regression model controlling for age, gender, ejection fraction, New York Heart Association, comorbidity, angiotensin-converting enzyme inhibitor use, and p-blocker use. Receiver operating characteristic curves showed that adherence rates above 88% produced the optimal combination of sensitivity and specificity with respect to predicting better event-free survival. With 88% as the adherence cutpoint, the hazard ratio for time to first event for the nonadherent group was 2.2 by dose count (P =.021) and 3.2 by dose day (P =.002). Conclusion The results of this study provide clinicians and researchers with an evidence-based recommendation about the level of adherence needed to achieve optimal clinical outcomes. (Am Heart J 2009; 157:285-91.) C1 [Wu, Jia-Rong; Moser, Debra K.; Rayens, Mary Kay; Chung, Misook L.; Lennie, Terry A.] Univ Kentucky, Coll Nursing, Lexington, KY 40536 USA. [De Jong, Marla J.] USA, Res & Mat Command, DoD Blast Injury Res Program, Coordinating Off, Ft Detrick, MD USA. [Riegel, Barbara] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA. RP Wu, JR (reprint author), Univ Kentucky, Coll Nursing, 509 CON Bldg,760 Rose St, Lexington, KY 40536 USA. EM jiarongwu@uky.edu FU NCRR NIH HHS [M01 RR002602-200220, M01 RR000034-410538, M01 RR002602-210211, M01 RR000034-380538, M01 RR002602, M01 RR002602-225140, M01 RR002602-210220, M01 RR002602-200211, M01 RR000034-400619, M01 RR002602-225137, M01 RR002602-22S15353, M01 RR000034-420538, M01 RR000034, M01 RR000034-390538, M01 RR000034-40S10619, M01 RR000034-370538, M01 RR002602-22S15356]; NINR NIH HHS [R01 NR008567-01A1, R01 NR008567, P20 NR010679-01, R01 NR008567-04, P20 NR010679-02, R01 NR008567-02, R01 NR008567-05, 1P20NR010679, R01 NR008567-03, P20 NR010679] NR 49 TC 67 Z9 68 U1 1 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD FEB PY 2009 VL 157 IS 2 BP 285 EP 291 DI 10.1016/j.ahj.2008.10.001 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 409DL UT WOS:000263486300010 PM 19185635 ER PT J AU Abadie, JM van Hoeven, KH Wells, JM AF Abadie, Jude M. van Hoeven, K. H. Wells, Justin M. TI Are Renal Reference Intervals Required When Screening for Plasma Cell Disorders With Serum Free Light Chains and Serum Protein Electrophoresis? SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article DE Free light chains; Monoclonal gammopathy; Electrophoresis ID BENCE-JONES PROTEIN; MONOCLONAL GAMMOPATHIES; MULTIPLE-MYELOMA; AL AMYLOIDOSIS; URINE; IMMUNOFIXATION; ASSAYS AB Renal impairment and polyclonal hypergammaglobulinemia may abnormally increase the serum free light chain (sFLC) ratio, giving false-positive results with current reference intervals. We measured sFLCs with concomitant serum protein electrophoresis (SPEP) and urine protein electrophoresis (UPEP) in 281 patients. Results were interpreted relative to renal function (serum creatinine concentrations) and polyclonal hypergammaglobulinemia. Overall, 78 plasma cell disorders (PCDs) were detected with the serum panel of SPEP/sFLC vs 76 with SPEP/UPEP. In 13 samples with negative SPEP/UPEP, mildly increased ratios up to 3.1 (normal, 0.26-1.65) were observed: 10 were associated with increased serum creatinine and I with polyclonal hypergammaglobulinemia: 2 were unassociated with either condition. In 2 samples, decreased kappa/lambda ratios were identified that were clinically significant despite normal SPEP/UPEP. Two monoclonal gammopathies were identfied with UPEP and sFLC, but samples were normal with SPEP Screening for PCDs with a serum panel consisting of SPEP and the sFLC assays is a highly sensitive approach that could eliminate the need for UPEP. A mildly increased kappa/lambda ratio up to 3.1 was observed with increased serum creatinine and/or polyclonal hypergammaglobulinemia that was consistent with pathophysiologic changes, and, therefore, renal reference intervals are recommended. C1 [Abadie, Jude M.; Wells, Justin M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Abadie, JM (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW,DPALS Core Lab Bldg 2 2B-48, Washington, DC 20307 USA. NR 18 TC 30 Z9 32 U1 0 U2 2 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD FEB PY 2009 VL 131 IS 2 BP 166 EP 171 DI 10.1309/AJCPR2M4EUYNHLGM PG 6 WC Pathology SC Pathology GA 395RC UT WOS:000262540200002 PM 19141376 ER PT J AU Miller, MA Levsky, ME Enslow, W Rosin, A AF Miller, Michael A. Levsky, Marc E. Enslow, William Rosin, Alex TI Randomized evaluation of octreotide vs prochlorperazine for ED treatment of migraine headache SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article CT ACEP Scientific Assembly 2007 CY OCT, 2007 CL Seattle, WA SP ACEP ID DOUBLE-BLIND TRIAL; DROPERIDOL VS. PROCHLORPERAZINE; EMERGENCY-DEPARTMENTS; CLUSTER HEADACHE; SOMATOSTATIN; NEUROPEPTIDES; KETOROLAC; ATTACKS AB Patients with headaches account for approximately 2% of all ED visits, with migraines being the most common defined primary headache syndrome. Our goals were to evaluate the efficacy of intravenous octreotide (OC) for the treatment of migraines, when compared to standard therapy with prochlorperazine. Methods: The study was conducted as a double-blinded, randomized controlled trial. Each subject received either 100 tug of octreotide or 10 mg of prochlorperazine intravenously for a 2-minute period. Results: Comparison of the change in median visual analog scale scores for 60 minutes demonstrated that octreotide was less effective at reducing pain (P = .03) and producing clinical success (P < .01). Restlessness consistent with akathisia was noted by 35% of the PC group and 8% of the OC group (P < .01). At 60 minutes, rescue medication was required by 48% of the patients in the OC group, whereas 10% of the PC group required such therapy (P < .01). All 44 patients were contacted for follow-up at 48 to 72 hours after enrollment. At that tithe, 10% of the prochlorperazine and 25% of the octreotide patients had experienced some headache recurrence (P = .1). Conclusion: Prochlorperazine was statistically superior to octreotide in clinical success rate and decrease in pain in migraine patients but caused more restlessness and sedation. (C) 2009 Published by Elsevier Inc. C1 [Miller, Michael A.; Enslow, William] Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. [Levsky, Marc E.; Rosin, Alex] Carl R Darnall Army Med Ctr, Dept Emergency Med, Ft Hood, TX 76544 USA. RP Miller, MA (reprint author), Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. EM michael.adam.miller@us.army.mil NR 21 TC 13 Z9 13 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD FEB PY 2009 VL 27 IS 2 BP 160 EP 164 DI 10.1016/j.ajem.2008.01.015 PG 5 WC Emergency Medicine SC Emergency Medicine GA 416DN UT WOS:000263985600005 PM 19371522 ER PT J AU Shi, T Moulton, VR Lapchak, PH Deng, GM Lucca, JJD Tsokos, GC AF Shi, Tong Moulton, Vaishali R. Lapchak, Peter H. Deng, Guo-Min Lucca, Jurandir J. Dalle Tsokos, George C. TI Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY LA English DT Article DE cytochalasin D; complement; deposition ID ALTERNATIVE COMPLEMENT PATHWAY; CORONARY-ARTERY OCCLUSION; APOPTOTIC CELL CLEARANCE; ISCHEMIA/REPERFUSION INJURY; CYTOCHALASIN-D; MESENTERIC ISCHEMIA/REPERFUSION; BETA(2)-GLYCOPROTEIN I; MICE; POLYMERIZATION; FILAMENTS AB Shi T, Moulton VR, Lapchak PH, Deng G, Dalle Lucca JJ, Tsokos GC. Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 296: G339-G347, 2009. First published December 18, 2008; doi:10.1152/ajpgi.90607.2008.-Ischemiareperfusion (IR) injury represents a major clinical challenge, which contributes to morbidity and mortality during surgery. The critical role of natural immunoglobulin M (IgM) and complement in tissue injury has been demonstrated. However, cellular mechanisms that result in the deposition of natural IgM and the activation of complement are still unclear. In this report, using a murine intestinal IR injury model, we demonstrated that the beta-actin protein in the small intestine was cleaved and actin filaments in the columnar epithelial cells were aggregated after a transient disruption during 30 min of ischemia. Ischemia also led to deposition of natural IgM and complement 3 (C3). A low dose of cytochalasin D, a depolymerization reagent of the actin cytoskeleton, attenuated this deposition and also attenuated intestinal tissue injury in a dose-dependent manner. In contrast, high doses of cytochalasin D failed to worsen the injury. These data indicate that ischemia-mediated aggregation of the actin cytoskeleton, rather than its disruption, results directly in the deposition of natural IgM and C3. We conclude that ischemia-mediated aggregation of the actin cytoskeleton leads to the deposition of natural IgM and the activation of complement, as well as tissue injury. C1 [Shi, Tong; Moulton, Vaishali R.; Lapchak, Peter H.; Deng, Guo-Min; Tsokos, George C.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02215 USA. [Lucca, Jurandir J. Dalle] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Shi, T (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, 330 Brookline Ave,CLS 928, Boston, MA 02215 USA. EM tshi@bidmc.harvard.edu; gtsokos@bidmc.harvard.edu RI Ji, Haofeng/G-6206-2012; OI Lapchak, Peter/0000-0001-8597-088X FU Medical Research and Materiel Command [W81XWH-07-1-0286] FX The work was supported by Grant no. W81XWH-07-1-0286 from Medical Research and Materiel Command. NR 51 TC 14 Z9 15 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1857 J9 AM J PHYSIOL-GASTR L JI Am. J. Physiol.-Gastroint. Liver Physiol. PD FEB PY 2009 VL 296 IS 2 BP G339 EP G347 DI 10.1152/ajpgi.90607.2008 PG 9 WC Gastroenterology & Hepatology; Physiology SC Gastroenterology & Hepatology; Physiology GA 399EC UT WOS:000262782200023 PM 19095765 ER PT J AU Cheuvront, SN Ely, BR Kenefick, RW Michniak-Kohn, BB Rood, JC Sawka, MN AF Cheuvront, Samuel N. Ely, Brett R. Kenefick, Robert W. Michniak-Kohn, Bozena B. Rood, Jennifer C. Sawka, Michael N. TI No effect of nutritional adenosine receptor antagonists on exercise performance in the heat SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE caffeine; quercetin; thermoregulation; central fatigue; dietary supplements ID CYCLING TIME TRIAL; CAFFEINE INGESTION; AMBIENT-TEMPERATURE; PROLONGED EXERCISE; BLOOD-FLOW; RESPONSES; FATIGUE; FLAVONOIDS; SYSTEM; SUPPLEMENTATION AB Cheuvront SN, Ely BR, Kenefick RW, Michniak-Kohn BB, Rood JC, Sawka MN. No effect of nutritional adenosine receptor antagonists on exercise performance in the heat. Am J Physiol Regul Integr Comp Physiol 296: R394-R401, 2009. First published November 19, 2008; doi: 10.1152/ajpregu.90812.2008.-Nutritional adenosine receptor antagonists can enhance endurance exercise performance in temperate environments, but their efficacy during heat stress is not well understood. This double-blinded, placebo-controlled study compared the effects of an acute dose of caffeine or quercetin on endurance exercise performance during compensable heat stress (40 degrees C, 20-30% rh). On each of three occasions, 10 healthy men each performed 30-min of cycle ergometry at 50% (V) over dot O(2peak) followed by a 15-min performance time trial after receiving either placebo (Group P), caffeine (Group C; 9 mg/kg), or quercetin (Group Q; 2,000 mg). Serial blood samples, physiological (heart rate, rectal, and mean skin body temperatures), perceptual (ratings of perceived exertion, pain, thermal comfort, motivation), and exercise performance measures (total work and pacing strategy) were made. Supplementation with caffeine and quercetin increased preexercise blood concentrations of caffeine (55.62 +/- 4.77 mu M) and quercetin (4.76 +/- 2.56 mu M) above their in vitro inhibition constants for adenosine receptors. No treatment effects were observed for any physiological or perceptual measures, with the exception of elevated rectal body temperatures (0.20-0.30 degrees C; P < 0.05) for Group C vs. Groups Q and P. Supplementation did not affect total work performed (Groups P: 153.5 +/- 28.3, C: 157.3 +/- 28.9, and Q: 151.1 +/- 31.6 kJ; P > 0.05) or the self-selected pacing strategy employed. These findings indicate that the nutritional adenosine receptor antagonists caffeine and quercetin do not enhance endurance exercise performance during compensable heat stress. C1 [Cheuvront, Samuel N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Michniak-Kohn, Bozena B.] Rutgers State Univ, Ernest Mario Sch Pharm, Piscataway, NJ USA. [Rood, Jennifer C.] Pennington Biomed Res Ctr, Baton Rouge, LA USA. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM samuel.n.cheuvront@us.army.mil FU Defense Advanced Research Projects Agency; U.S. Army [W911QY-07-C0027] FX This research was supported, in part, by funding from the Defense Advanced Research Projects Agency and U.S. Army Contract W911QY-07-C0027. NR 52 TC 35 Z9 36 U1 0 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD FEB PY 2009 VL 296 IS 2 BP R394 EP R401 DI 10.1152/ajpregu.90812.2008 PG 8 WC Physiology SC Physiology GA 399DS UT WOS:000262781200024 PM 19020291 ER PT J AU Gerhardt, RT De Lorenzo, RA Oliver, J Holcomb, JB Pfaff, JA AF Gerhardt, Robert T. De Lorenzo, Robert A. Oliver, Jeffrey Holcomb, John B. Pfaff, James A. TI Out-of-Hospital Combat Casualty Care in the Current War in Iraq SO ANNALS OF EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT 12th Annual TRISAT Trauma Symposium CY SEP, 2006 CL San Antonio, TX ID OPERATION-ENDURING-FREEDOM; SURGICAL-TEAM; ARMY; BATTLEFIELD; EXPERIENCE; INJURY; AFGHANISTAN; DEATH AB Study objective: We describe outcomes for battle casualties receiving initial treatment at a US Army consolidated battalion aid station augmented with emergency medicine practitioners, advanced medic treatment protocols, and active medical direction. Battalion aid stations are mobile facilities integral to combat units, providing initial phases of advanced trauma life support and then evacuation. The setting was a forward base in central Iraq, with units engaged in urban combat operations. Methods: This was a retrospective observational study. Rates of battle casualties, mechanism, evacuations, and outcome were calculated. Corresponding Iraqi theater-wide US casualty rates were also calculated for indirect comparison. Results: The study population consisted of 1.1% of the total US military population in the Iraqi theater. Data were available for all battle casualties. The study facility's battle casualty rate was 22.2%. The case fatality rate was 7.14%, and the out-of-theater evacuation rate was 27%. Analysis of evacuated patients revealed a study average Injury Severity Score of 10 (95% confidence interval [CI] 8 to 12). Concurrent theater aggregate US casualty rates are provided for contextual reference and include battle casualty rate of 6.7%, case fatality rate of 10.45%, out-of-theater evacuation rate of 18%, and average out-of-theater evacuation casualty Injury Severity Score of 10 (95% CI 9.5 to 10.5). Conclusion: The study battalion aid station experienced high casualty and evacuation rates while also demonstrating relatively low case fatality rates. A relatively high proportion of patients were evacuated out of the combat zone, reflecting both the battle casualty rate and number of patients surviving. Future effort should focus on improving out-of-hospital combat casualty data collection and prospective validation of emergency medicine-based out-of-hospital battlefield care and medical direction. [Ann Emerg Med. 2009;53:169-174.] C1 [Gerhardt, Robert T.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. RP Gerhardt, RT (reprint author), Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Robert.Gerhardt@amedd.army.mil NR 33 TC 36 Z9 36 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD FEB PY 2009 VL 53 IS 2 BP 169 EP 174 DI 10.1016/j.annemergmed.2008.04.013 PG 6 WC Emergency Medicine SC Emergency Medicine GA 405LI UT WOS:000263225900002 PM 18472183 ER PT J AU De Lorenzo, RA AF De Lorenzo, Robert A. TI Thinking the Unthinkable SO ANNALS OF EMERGENCY MEDICINE LA English DT Editorial Material ID HEALTH-CARE; DISASTER PREPAREDNESS C1 [De Lorenzo, Robert A.] Brooke Army Med Ctr, Dept Clin Invest, MCHE CI, Ft Sam Houston, TX 78234 USA. [De Lorenzo, Robert A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD USA. RP De Lorenzo, RA (reprint author), Brooke Army Med Ctr, Dept Clin Invest, MCHE CI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Robert.DeLorenzo@amedd.army.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD FEB PY 2009 VL 53 IS 2 BP 223 EP 225 DI 10.1016/j.annemergmed.2008.02.012 PG 3 WC Emergency Medicine SC Emergency Medicine GA 405LI UT WOS:000263225900011 PM 18387705 ER PT J AU Wahi, MM Shah, N Schrock, CE Rosemurgy, AS Goldin, SB AF Wahi, Monika M. Shah, Nilay Schrock, Christopher E. Rosemurgy, Alexander S., II Goldin, Steven B. TI Reproductive Factors and Risk of Pancreatic Cancer in Women: A Review of the Literature SO ANNALS OF EPIDEMIOLOGY LA English DT Review DE Pancreatic neoplasms; Review literature as topic; Reproductive history women; Risk factors ID GROWTH-FACTOR-I; RANDOMIZED CONTROLLED TRIAL; FRANCISCO-BAY AREA; UNITED-STATES; CIGARETTE-SMOKING; ANTHROPOMETRIC FACTORS; DIABETES-MELLITUS; HORMONAL ASPECTS; PROSTATE-CANCER; BREAST-CANCER AB PURPOSE: Pancreatic cancer (PCA) is the fourth leading cause of cancer death in the United States. The male-to-female incidence and mortality ratio of PCA is 1.1-2.0. One possible explanation for this difference is that female hormone exposure is protective for the development of PCA. Several hypotheses were investigated in this systematic review: (1) increased exposure to estrogen through early menarche and later menopause is associated with a decreased risk of PCA; (2) increased exposure to pregnancy is associated with decreased risk of PCA; and (3) increased exposure to oral contraceptives and/or hormone replacement therapy is associated with decreased risk of PCA. METHODS: Of 371 articles identified, 10 case-control and 5 cohort studies met the criteria for Our review. Odds ratios for case-control studies and hazard ratios for cohort studies and their accompanying 95% confidence intervals for analyses relevant to our hypotheses were considered in the review. RESULTS: For all 3 hypotheses, studies displayed inconsistent results, and this may have been Line to the diversity of Study populations, exposure quantification, analysis approach, confounding and other limitations, and biases across Studies. CONCLUSIONS: As there was no strong Support for any of the 3 hypotheses, it appears that reproductive factors are nor associated with the development of PCA in women. C1 [Wahi, Monika M.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Wahi, Monika M.] Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA. [Schrock, Christopher E.; Rosemurgy, Alexander S., II; Goldin, Steven B.] Univ S Florida, Coll Med, Dept Surg, Tampa, FL 33612 USA. RP Wahi, MM (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM monika.wahi@us.army.mil NR 66 TC 14 Z9 14 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD FEB PY 2009 VL 19 IS 2 BP 103 EP 111 DI 10.1016/j.annepidem.2008.11.003 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 407UC UT WOS:000263388800006 PM 19185803 ER PT J AU Ellsworth, R Becker, TE Progar, C Deyarmin, B Shriver, CD AF Ellsworth, R. Becker, T. E. Progar, C. Deyarmin, B. Shriver, C. D. TI Characterization of screen versus non-screen detected breast tumors SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract C1 [Ellsworth, R.] Henry M Jackson Fdn Advancement Mil Med, Windber, PA USA. [Deyarmin, B.] Windber Res Inst, Windber, PA USA. [Becker, T. E.; Progar, C.; Shriver, C. D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2009 VL 16 SU 1 BP 48 EP 48 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA V16GF UT WOS:000207857400152 ER PT J AU Clifton, GT Holmes, JP Patel, R Benavides, LC Gates, JD Hueman, MT Mittendorf, EA Ponniah, S Peoples, GE AF Clifton, G. T. Holmes, J. P. Patel, R. Benavides, L. C. Gates, J. D. Hueman, M. T. Mittendorf, E. A. Ponniah, S. Peoples, G. E. TI Use of booster inoculations to sustain the clinical effect of an adjuvant breast cancer vaccine SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract C1 [Clifton, G. T.; Benavides, L. C.; Gates, J. D.; Peoples, G. E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Patel, R.] Joyce Murtha Breast Care Ctr, Winber, PA USA. [Holmes, J. P.] USN, Med Ctr, San Diego, CA 92152 USA. [Hueman, M. T.] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. [Mittendorf, E. A.] UT MD Anderson Canc Ctr, Houston, TX USA. [Ponniah, S.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2009 VL 16 SU 1 BP 58 EP 58 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA V16GF UT WOS:000207857400186 ER PT J AU Henry, LR Horst, LB Howard, RS Solomon, NP Eberhardt, C Coppit, GL Shaha, AR Stojadinovic, A AF Henry, L. R. Horst, L. B. Howard, R. S. Solomon, N. P. Eberhardt, C. Coppit, G. L. Shaha, A. R. Stojadinovic, A. TI Validation of the Voice Handicap Index in Predicting Voice Dysfunction after Thyroidectomy SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract C1 [Henry, L. R.] Uniformed Serv Univ Hlth Sci, Natl Naval Med Ctr, United States Mil Canc Inst, Bethesda, MD 20814 USA. [Shaha, A. R.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. [Stojadinovic, A.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, United States Mil Canc Inst, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2009 VL 16 SU 1 BP 63 EP 63 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA V16GF UT WOS:000207857400208 ER PT J AU Henry, LR Horst, LB Howard, RS Gurevich-Uvena, J Coppit, GL Felix, TL Solomon, NP Stojadinovic, A AF Henry, L. R. Horst, L. B. Howard, R. S. Gurevich-Uvena, J. Coppit, G. L. Felix, T. L. Solomon, N. P. Stojadinovic, A. TI Functional Voice Outcomes after Thyroidectomy: Are early reported voice symptoms related to durable laryngoscopic abnormalities? SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract C1 [Henry, L. R.] Uniformed Serv Univ Hlth Sci, Natl Naval Med Ctr, US Mil Canc Inst, Bethesda, MD 20814 USA. [Stojadinovic, A.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2009 VL 16 SU 1 BP 64 EP 64 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA V16GF UT WOS:000207857400209 ER PT J AU Ricciardi, R Metter, EJ Cavanaugh, EW Ghambaryan, A Talbot, LA AF Ricciardi, Richard Metter, E. Jeffery Cavanaugh, Erica W. Ghambaryan, Anna Talbot, Laura A. TI Predicting cardiovascular risk using measures of regional and total body fat SO APPLIED NURSING RESEARCH LA English DT Article ID CORONARY-HEART-DISEASE; BIOELECTRICAL-IMPEDANCE ANALYSIS; TO-HIP RATIO; WAIST CIRCUMFERENCE; MASS INDEX; METABOLIC SYNDROME; POSTMENOPAUSAL WOMEN; ABDOMINAL OBESITY; ADIPOSE-TISSUE; VISCERAL FAT AB Excessive body fat is associated with increased risk for coronary heart disease (CHD). Various anthropometric methods are currently used to quantify regional and total body fat. The objectives of this study were to provide more insight into differences in cutoff points between methods for measuring total body fat and those for measuring regional body fat, independently and in combination, and to determine how well anthropometric and bioelectrical impedance methods of estimating body composition predict cardiovascular risk in a sample of unfit National Guard soldiers. Unfit healthy men (n = 123) and women (n = 32) between 21 and 55 years old from the Army National Guard were assessed for total and regional body fat. After having their degree of total and regional body fat assessed, the participants were categorized by level of body fat and 10-year CHD risk. Comparisons and predictions were made between degree of total as well as regional body fat and 10-year CHD risk estimated from Framingham Heart Study equations. A significant positive relationship was observed between waist circumference and 10-year CHD risk in men. When controlling for age, waist circumference was predictive of 10-year CHD risk, contributing to 6.4% of the variance, whereas waist-to-hip ratio did not contribute to the model significantly. The results of this study show that waist circumference is the best measure for identifying unfit male individuals at risk for CHD. (c) 2009 Elsevier Inc. All rights reserved. C1 [Ricciardi, Richard] Walter Reed Army Med Ctr, Walter Reed Stn, Washington, DC 20012 USA. [Metter, E. Jeffery] Harbor Hosp, NIA, Intramural Res Program, NIH, Baltimore, MD 21225 USA. [Cavanaugh, Erica W.] Henry M Jackson Fdn, Rockville, MD 20852 USA. [Ghambaryan, Anna] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA. [Talbot, Laura A.] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. RP Ricciardi, R (reprint author), Walter Reed Army Med Ctr, Walter Reed Stn, Washington, DC 20012 USA. EM richard.ricciardi@us.army.mil; metterj@grc.nia.nih.gov; ewitham@usuhs.mil; aghambaryan@usuhs.mil; ltalbot@usuhs.mil FU Uniformed Services University of the Health Sciences; National Institutes of Health-National Institute on Aging FX This research was sponsored by the TriService Nursing Research Program of the Uniformed Services University of the Health Sciences and in part by the Intramural Research Program of the National Institutes of Health-National Institute on Aging; however, the information or content and conclusions do not necessarily represent the official positions or policies of the Triservice Nursing Research Program, the Uniformed Services University of the Health Sciences, the Department of Defense, the National Institutes of Health, and the U.S. Government. Neither should any official endorsement by these entities be inferred. NR 32 TC 6 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0897-1897 J9 APPL NURS RES JI Appl. Nurs. Res. PD FEB PY 2009 VL 22 IS 1 BP 2 EP 9 DI 10.1016/j.apnr.2007.01.011 PG 8 WC Nursing SC Nursing GA 409BG UT WOS:000263480600002 PM 19171289 ER PT J AU Demirbilek, Z Morrison, D AF Demirbilek, Zeki Morrison, Denby TI Tribute to Subrata Kumar Chakrabarti SO APPLIED OCEAN RESEARCH LA English DT Biographical-Item C1 [Demirbilek, Zeki] USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. [Morrison, Denby] Shell Int Explorat & Prod Inc, EP Projects, Shell Woodcreek, Houston, TX 77001 USA. RP Demirbilek, Z (reprint author), USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. EM zeki.demirbilek@usace.army.mil; denby.morrison@shell.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-1187 J9 APPL OCEAN RES JI Appl. Ocean Res. PD FEB PY 2009 VL 31 IS 1 BP 1 EP 3 DI 10.1016/j.apor.2009.04.003 PG 3 WC Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 493FD UT WOS:000269718800001 ER PT J AU Druger, SD Czege, J Li, ZZ Bronk, BV AF Druger, Stephen D. Czege, Jozsef Li, Zhaozhang Bronk, Burt V. TI Light scattering calculations exploring sensitivity of depolarization ratio to shape changes. I. Single spores in air SO APPLIED OPTICS LA English DT Article ID DISCRETE-DIPOLE APPROXIMATION AB Calculations of the depolarization ratio, D(Theta,lambda) = 1 - < S-22 >/< S-11 >, for light scattered from an ensemble or cloud of single aerosolized spores in air were studied using the discrete dipole approximation (DDA), sometimes also called the coupled-dipole approximation. Here S-ij is the appropriate Mueller matrix element for scattering angle Theta and wavelength 2. The effect of modest shape changes on D(Theta,lambda) was determined. The shapes compared were prolate ellipsoids versus right circular cylinders joined smoothly to end caps consisting of hemispheres of the same diameter as the cylinder. Using the same models, the graphs of < S-34 >/< S-11 > versus angle were compared with those for D(Theta,lambda). The latter shows sensitivity to length in some cases we examined, while < S-34 >/< S-11 > does not. Size parameters and optical constants suggested by measurements of Bacillus cereus endospores were used. An ensemble of spores was modeled with prolate spheroids. The results of this model were compared with results of a model using the same size and optical parameters, but for capped cylinders. The two models produced distinguishably different results for the same parameters. In calculations for all the graphs shown, averaging over random orientations was performed. Averaging over size distributions similar to those from experimental measurements was performed where indicated. The results show that measurements of D(Theta,lambda) could be quite useful in characterizing the shape of particles in an unknown aerosol and for distinguishing between two likely shapes, but not to reconstruct the shapes from the graphs alone without additional information. (C) 2009 Optical Society of America C1 [Druger, Stephen D.] Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA 01854 USA. [Czege, Jozsef; Li, Zhaozhang] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Bronk, Burt V.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Bronk, Burt V.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Druger, SD (reprint author), Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA 01854 USA. EM steve_druger@uml.edu NR 14 TC 1 Z9 1 U1 0 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 1 PY 2009 VL 48 IS 4 BP 716 EP 724 DI 10.1364/AO.48.000716 PG 9 WC Optics SC Optics GA 422FR UT WOS:000264413400034 PM 19183599 ER PT J AU Brestoff, JR Clippinger, B Spinella, T von Duvillard, SP Nindl, B Arciero, PJ AF Brestoff, Jonathan R. Clippinger, Benjamin Spinella, Thomas von Duvillard, Serge P. Nindl, Bradley Arciero, Paul J. TI An acute bout of endurance exercise but not sprint interval exercise enhances insulin sensitivity SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME LA English DT Article DE insulin sensitivity; endurance exercise; sprint interval exercise; cytokines ID HUMAN SKELETAL-MUSCLE; NECROSIS-FACTOR-ALPHA; 5'-AMP-ACTIVATED PROTEIN-KINASE; WEIGHT-LOSS; GLUCOSE-TOLERANCE; PHYSICAL-ACTIVITY; MITOCHONDRIAL-FUNCTION; ECCENTRIC EXERCISE; TRAINING INCREASES; HEALTHY-SUBJECTS AB An acute bout of endurance exercise (EE) enhances insulin sensitivity, but the effects of sprint interval exercise (SIE) have not yet been described. We sought to compare insulin sensitivity at baseline and after an acute bout of EE and SIE in healthy men (n = 8) and women (n = 5) (age, 20.7 +/- 0.3 years; peak oxygen consumption (VO(2peak)), 42.6 +/- 1.7 mL.kg(-1).min(-1); <1.5 days.week(-1) structured exercise; body fat, 21.1 +/- 1.9%). Subjects underwent 3 oral glucose tolerance tests (OGTTs) the day after each of the following 3 conditions: no exercise, baseline (OGTT(B)); SIE at similar to 125% VO(2peak) (OGTT(SIE)); and EE at similar to 75% VO(2peak) (OGTT(EE)). SIE and EE sessions were randomized for each subject. Subjects consumed identical meals the day preceding each OGTT. Two insulin sensitivity indices - composite whole-body insulin sensitivity index (ISI-COMP) and ISI-hepatic insulin sensitivity (HOMA) - were calculated, using previously validated formulas (ISI-COMP = 10000/root(glucose(fasting) x insulin(fasting) x glucose(mean) OGTT x insulin(mean) OGTT); ISI-HOMA = 22.5/ (insulin(fasting) x glucose(fasting))), and the plasma concentrations of cytokines interleukin-6 and tumor necrosis factor-alpha were measured. There were no differences by sex for any condition (men vs. women, p > 0.05). Pearson's correlation coefficients between ISI-COMP and ISI-HOMA for each condition were highly correlated (p < 0.01), and followed similar patterns of response. ISI-COMP(EE) was 71.4% higher than ISI-COMP(B) (8.4 +/- 1.4 vs. 4.9 +/- 1.0; p < 0.01) and 40.0% higher than ISI-COMP(SIE) (8.4 +/- 1.4 vs. 6.0 +/- 1.5; p < 0.05), but there was no difference between ISI-COMPB and ISI-COMPSIE (p = 0.182). VO(2peak) was highly correlated with both ISI-COMP and ISI-HOMA during baseline and SIE test conditions (p < 0.02). These findings demonstrate that an acute bout of EE, but not SIE, increases insulin sensitivity relative to a no-exercise control condition in healthy males and females. While these findings underscore the use of regular EE as an effective intervention strategy against insulin resistance, additional research examining repeated sessions of SIE on insulin sensitivity is warranted. C1 [Brestoff, Jonathan R.; Clippinger, Benjamin; Spinella, Thomas; Arciero, Paul J.] Skidmore Coll, Dept Exercise Sci, Saratoga Springs, NY 12866 USA. [Nindl, Bradley] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [von Duvillard, Serge P.] Salzburg Univ, Dept Sport Sci & Kinesiol, A-5020 Salzburg, Austria. RP Arciero, PJ (reprint author), Skidmore Coll, Dept Exercise Sci, Saratoga Springs, NY 12866 USA. EM parciero@skidmore.edu NR 41 TC 15 Z9 15 U1 4 U2 11 PU NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS PI OTTAWA PA BUILDING M 55, OTTAWA, ON K1A 0R6, CANADA SN 1715-5312 J9 APPL PHYSIOL NUTR ME JI Appl. Physiol. Nutr. Metab. PD FEB PY 2009 VL 34 IS 1 BP 25 EP 32 DI 10.1139/H08-126 PG 8 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA 439CK UT WOS:000265604600004 PM 19234582 ER PT J AU Piva, SR Fitzgerald, GK Irrgang, JJ Fritz, JM Wisniewski, S McGinty, GT Childs, JD Domenech, MA Jones, S Delitto, A AF Piva, Sara R. Fitzgerald, G. Kelley Irrgang, James J. Fritz, Julie M. Wisniewski, Stephen McGinty, Gerald T. Childs, John D. Domenech, Manuel A. Jones, Scott Delitto, Anthony TI Associates of Physical Function and Pain in Patients with Patellofemoral Pain Syndrome SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Anxiety; Fear; Pain; Patella; Quality of life; Rehabilitation ID LOW-BACK-PAIN; FEAR-AVOIDANCE BELIEFS; ANTERIOR KNEE PAIN; CRUCIATE LIGAMENT RECONSTRUCTION; CLOSED KINETIC CHAIN; CHRONIC MUSCULOSKELETAL PAIN; CHONDROMALACIA PATELLAE; PSYCHOLOGICAL-FACTORS; QUADRICEPS STRENGTH; SELF-EFFICACY AB Objectives: To explore whether impairment of muscle strength, soft tissue length, movement control, postural and biomechanic alterations, and psychologic factors are associated with physical function and pain in patients with patellofemoral pain syndrome (PFPS). Design: Cross-sectional study. Setting: Rehabilitation outpatient. Participants: Seventy-four patients diagnosed with PFPS. Interventions: Not applicable. Main Outcome Measures: Measurements were self-reported function and pain; strength of quadriceps, hip abduction, and hip external rotation; length of hamstrings, quadriceps, plantar flexors, iliotibial band/tensor fasciae latae complex, and lateral retinaculum; foot pronation; Q-angle; tibial torsion; visual observation of quality of movement during a lateral step-down task; anxiety; and fear-avoidance beliefs. Results: After controlling for age and sex, anxiety and fear-avoidance beliefs about work and physical activity were associated with function, while only fear-avoidance beliefs about work and physical activity were associated with pain. Conclusions: Psychologic factors were the only associates of function and pain in patients with PFPS. Factors related to physical impairments did not associate to function or pain. Our results should be validated in other samples of patients with PFPS. Further studies should determine the role of other psychologic factors, and how they relate to anxiety and fear-avoidance beliefs in these patients. C1 [Piva, Sara R.] Univ Pittsburgh, Dept Phys Therapy, SHRS, Pittsburgh, PA 15260 USA. [Irrgang, James J.] Univ Pittsburgh, Dept Orthopaed Surg, Pittsburgh, PA 15260 USA. [Wisniewski, Stephen] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA. [Fritz, Julie M.] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA. [McGinty, Gerald T.] USAF Acad, Colorado Springs, CO USA. [Childs, John D.] Baylor Univ, USA, Doctor Program Phys Therapy, Ft Sam Houston, TX USA. [Domenech, Manuel A.] Texas Tech Univ, Hlth Sci Ctr, Dept Rehabil Sci, Odessa, TX USA. [Jones, Scott] Ramstein Air Base, Ramstein Outpatient Phys Med Clin, Kaiserslautern, Germany. RP Piva, SR (reprint author), Univ Pittsburgh, Dept Phys Therapy, SHRS, Room 6035,Forbes Tower, Pittsburgh, PA 15260 USA. EM spiva@pitt.edu OI Wisniewski, Stephen/0000-0002-3877-9860 FU Clinical Research Grant Program of the Orthopacclic Section of the American Physical Therapy Association; Pennsylvania Physical Therapy Association Research Fund FX Supported by the Clinical Research Grant Program of the Orthopacclic Section of the American Physical Therapy Association, and the Pennsylvania Physical Therapy Association Research Fund. NR 89 TC 23 Z9 24 U1 0 U2 16 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD FEB PY 2009 VL 90 IS 2 BP 285 EP 295 DI 10.1016/j.apmr.2008.08.214 PG 11 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 410KX UT WOS:000263577000011 PM 19236982 ER PT J AU Killgore, WDS Grugle, NL Reichardt, RM Killgore, DB Balkin, TJ AF Killgore, William D. S. Grugle, Nancy L. Reichardt, Rebecca M. Killgore, Desiree B. Balkin, Thomas J. TI Executive Functions and the Ability to Sustain Vigilance During Sleep Loss SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE sleep deprivation; individual differences; executive function; prefrontal cortex; vigilance; PVT ID PSYCHOMOTOR VIGILANCE; DECISION-MAKING; INDIVIDUAL-DIFFERENCES; WORKING-MEMORY; NEURAL BASIS; ONE NIGHT; INTERINDIVIDUAL DIFFERENCES; TASK-DIFFICULTY; RECOVERY SLEEP; 24 H AB Introduction: There is considerable individual variability in the ability to sustain performance during sleep loss. Preliminary evidence suggests that individuals with higher trait-like activation/functioning of the prefrontal cortex may be less vulnerable to fatigue. Methods: We tested this hypothesis in a sample of 54 healthy volunteers who were assessed hourly, oil a variant of the Psychomotor Vigilance Test during 41 h of sleep deprivation. A subset of these subjects, representing the top and bottom 25%, of the sample based on their ability to sustain vigilance performance during sleep deprivation, were compared with respect to baseline neurocognitive abilities. Results: The sleep deprivation Resistant group (N = 13) scored significantly higher than the sleep deprivation Vulnerable (N = 13), group on all three baseline tasks assessing prefrontal executive function abilities (letter fluency, Stroop Color-Word test, Color Trails Form 2), whereas no differences were found on non-executive function tasks. Similarly, groups showed differences on demographic variables Including age, education, hand preference, morningness-eveningness preference, global intellectual ability, or pre-study sleep history. Discussion: Findings are consistent with the hypothesis that greater prefrontal/executive functioning may he protective against the adverse effects of sleep deprivation and suggest that baseline executive function testing may prove useful for prediction of resilience during sleep loss. C1 [Killgore, William D. S.] Harvard Univ, Sch Med, McLean Hosp, Neuroimaging Ctr, Belmont, MA 02478 USA. [Killgore, Desiree B.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. [Grugle, Nancy L.; Reichardt, Rebecca M.] USA, Med Res & Mat Command, Ft Detrick, MD USA. RP Killgore, WDS (reprint author), Harvard Univ, Sch Med, McLean Hosp, Neuroimaging Ctr, 115 Mill St, Belmont, MA 02478 USA. EM killgore@mclean.harvard.edu OI Killgore, William/0000-0002-5328-0208 NR 63 TC 30 Z9 30 U1 3 U2 16 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 2009 VL 80 IS 2 BP 81 EP 87 DI 10.3357/ASEM.2396.2009 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 399RX UT WOS:000262818100002 PM 19198192 ER PT J AU Arnett, CM Adrian, NR AF Arnett, Clint M. Adrian, Neal R. TI Cosubstrate independent mineralization of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by a Desulfovibrio species under anaerobic conditions SO BIODEGRADATION LA English DT Article DE Desulfovibrio; Explosive; Hexahydro-1,3,5-trinitro-1,3,5-triazine; RDX degradation; Sulfate-reducing bacteria ID SULFATE-REDUCING BACTERIA; CLOSTRIDIUM-BIFERMENTANS; MIXED CULTURE; BIODEGRADATION; EXPLOSIVES; BIOTRANSFORMATION; SLUDGE; SOIL; HEXAHYDRO-1-NITROSO-3,5-DINITRO-1,3,5-TRIAZINE; 2,4,6-TRINITROTOLUENE AB Past handling practices associated with the manufacturing and processing of the high explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) has resulted in extensive environmental contamination. In-situ biodegradation is a promising technology for remediating RDX contaminated sites but often relies on the addition of a cosubstrate. A sulfate-reducing bacterium isolated from an RDX-degrading enrichment culture was studied for its ability to grow on RDX as a sole source of carbon and nitrogen and for its ability to mineralize RDX in the absence of a cosubstrate. The results showed the isolate degraded 140 mu M RDX in 63 days when grown on RDX as a carbon source. Biomass within the carbon limited culture increased 9-fold compared to the RDX unamended controls. When the isolate was incubated with RDX as sole source of nitrogen it degraded 160 mu M RDX in 41 days and exhibited a 4-fold increase in biomass compared to RDX unamended controls. Radiolabeled studies under carbon limiting conditions with (14)C-hexahydro-1,3,5-trinitro-1,3,5-triazine confirmed mineralization of the cyclic nitramine. After 60 days incubation 26% of the radiolabel was recovered as (14)CO(2), while in the control bottles less than 1% of the radiolabel was recovered as (14)CO(2). Additionally, 2% of the radiolabeled carbon was found to be associated with the biomass. The 16S rDNA gene was sequenced and identified the isolate as a novel species of Desulfovibrio, having a 95.1% sequence similarity to Desulfovibrio desulfuricans. This is the first known anaerobic bacterium capable of mineralizing RDX when using it as a carbon and energy source for growth. C1 [Arnett, Clint M.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61821 USA. [Arnett, Clint M.; Adrian, Neal R.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61822 USA. RP Arnett, CM (reprint author), USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61821 USA. EM Clint.Arnett@usace.army.mil FU Oak Ridge Institute for Science and Education; U.S. Department of Energy; US Army Corps of Engineers FX This research was supported in part by an appointment at the Research Participation Program administered by the Oak Ridge Institute for Science and Education through a cooperative agreement between the U.S. Department of Energy and US Army Corps of Engineers. Although this research was conducted at the Construction Engineering Research Laboratory for the United States Army Engineer Research & Development Center, it has not been subjected to Army review and therefore does not necessarily reflect the views of the Army and no official endorsement should be inferred. NR 39 TC 16 Z9 16 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0923-9820 J9 BIODEGRADATION JI Biodegradation PD FEB PY 2009 VL 20 IS 1 BP 15 EP 26 DI 10.1007/s10532-008-9195-1 PG 12 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 389II UT WOS:000262085700002 PM 18459059 ER PT J AU Quinn, MJ Crouse, LCB McFarland, CA LaFiandra, EM Johnson, MS AF Quinn, Michael J., Jr. Crouse, Lee C. B. McFarland, Craig A. LaFiandra, Emily M. Johnson, Mark S. TI Reproductive and Developmental Effects and Physical and Chemical Properties of Pentaerythritol Tetranitrate (PETN) in the Rat SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY LA English DT Article DE pentaerythritol tetranitrate; PETN; reproduction; development AB Pentaerythritol tetranitrate (PETN) is an explosive chemical that has been detected in environmental media. Although previous toxicology studies have shown PETN to be relatively benign, a lack of available information concerning developmental and reproductive effects from oral PETN exposure was needed. Sprague-Dawley rats were exposed to oral daily adjusted volumetric doses of 0, 100, 500, or 1,000mg PETN/kg body mass in a corn oil vehicle for up to 56 days. Mating, duration of gestation, body weight, feed consumption, overall condition of adults, and the number, sex, and condition of pups were recorded. Histological examinations were also performed oil the ovaries, testes, and epididymides of animals from the control and the highest dose groups. Other environmental criteria, water solubility, octanol/water partition coefficient, and biodegradation rates of neat PETN were also determined. Only body weights and feed consumption were affected by treatment; however, these differences may be attributed more to volumetric adjustments of vehicle in the control and high-dose groups than to PETN toxicity. No adverse effects on development or reproduction from PETN exposure were observed. Water solubility, octanol water partition coefficient, and water suspension and biodegradation rates suggest PETN is unlikely to transport or bioaccumulate in the environment to any appreciable extent. Additionally, biotic processes are most likely faster in breaking down PETN than the abiotic processes involved in dissolving PETN in water. Birth Defects Res (Part B) 86:65-71, 2009. (C) 2009 Wiley-Liss, Inc. C1 [Quinn, Michael J., Jr.; Crouse, Lee C. B.; McFarland, Craig A.; LaFiandra, Emily M.; Johnson, Mark S.] USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, Aberdeen Proving Ground, MD 21010 USA. RP Quinn, MJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, Aberdeen Proving Ground, MD 21010 USA. EM michael.james.quinn@us.army.mil NR 12 TC 3 Z9 3 U1 0 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1542-9733 J9 BIRTH DEFECTS RES B JI Birth Defects Res. Part B-Dev. Reprod. Toxicol. PD FEB PY 2009 VL 86 IS 1 BP 65 EP 71 DI 10.1002/bdrb.20184 PG 7 WC Oncology; Genetics & Heredity; Toxicology SC Oncology; Genetics & Heredity; Toxicology GA 415FS UT WOS:000263920300006 PM 19197946 ER PT J AU Aluarado, R Chung, KK CanCio, LC Wolf, SE AF Aluarado, Ricardo Chung, Keuin K. CanCio, Leopoldo C. Wolf, Steuen E. TI Burn resuscitation SO BURNS LA English DT Review DE Burn resuscitation; Burns; Burn resuscitation evolution; Future consideration in burn resuscitation ID ABDOMINAL COMPARTMENT SYNDROME; HIGH-VOLUME HEMOFILTRATION; THERMALLY INJURED PATIENTS; FLUID RESUSCITATION; MAJOR BURNS; COLLOID RESUSCITATION; SHOCK RESUSCITATION; RINGERS SOLUTION; SALINE SOLUTION; DIARRHEA AB Current guidelines outlining the resuscitation of severely burned patients, in the United States, were developed over 30 years ago. Unfortunately, clinical burn resuscitation has not advanced significantly since that time despite ongoing research efforts. Many formulas exist and have been developed with the intention of providing appropriate, more precise fluid resuscitation with decreased morbidity as compared to the current standards, such as the Parkland and modified Brooke formulas. The aim of this review was to outline the evolution of burn resuscitation, while closely analyzing current worldwide guidelines, adjuncts to resuscitation, as well as addressing future goals. (C) 2008 Elsevier Ltd and ISBI. All rights reserved. C1 [Aluarado, Ricardo; CanCio, Leopoldo C.; Wolf, Steuen E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX USA. [Aluarado, Ricardo; Chung, Keuin K.; CanCio, Leopoldo C.; Wolf, Steuen E.] USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. RP Wolf, SE (reprint author), USA, Inst Surg Res, Burn Ctr, 3400 Rawley E Chambers,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM steven.wolf@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 67 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD FEB PY 2009 VL 35 IS 1 BP 4 EP 14 DI 10.1016/j.burns.2008.03.008 PG 11 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 405CY UT WOS:000263201200001 ER PT J AU McNeill, M Zanders, TB Morris, MJ AF McNeill, Matthew Zanders, Thomas B. Morris, Michael J. TI A 49-Year-Old Man With Concurrent Diagnoses of Lung Cancer, Sarcoidosis, and Multiple Regions of Adenopathy on Positron Emission Tomography SO CHEST LA English DT Editorial Material ID FINE-NEEDLE-ASPIRATION; ENDOSCOPIC ULTRASOUND C1 [McNeill, Matthew] Brooke Army Med Ctr, Internal Med Residency & Pulm Dis Serv, Ft Sam Houston, TX 78234 USA. [Zanders, Thomas B.; Morris, Michael J.] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. RP McNeill, M (reprint author), Brooke Army Med Ctr, Internal Med Residency & Pulm Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM matthew.mcneill@amedd.army.mil NR 11 TC 4 Z9 4 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD FEB PY 2009 VL 135 IS 2 BP 546 EP 549 DI 10.1378/chest.08-1221 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 405VH UT WOS:000263251800043 PM 19201718 ER PT J AU McNeill, M Hill, E Humphreys, C AF McNeill, Matthew Hill, Eric Humphreys, Christopher TI A 53-Year-Old Woman With a Myocardial Infarction, Hypotension, and Abdominal Distension SO CHEST LA English DT Editorial Material ID CARDIOPULMONARY-RESUSCITATION; NONSURGICAL CAUSES; PNEUMOPERITONEUM C1 [McNeill, Matthew] Brooke Army Med Ctr, Pulm Dis Serv, San Antonio, TX USA. [Humphreys, Christopher] Brooke Army Med Ctr, Dept Med & Emergency Med Residency, San Antonio, TX USA. [Hill, Eric] Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX USA. RP McNeill, M (reprint author), William Beaumont Army Med Ctr, 5005 N Piedras St, El Paso, TX 79920 USA. EM matthew.mcneill@amedd.army.mil NR 7 TC 0 Z9 0 U1 1 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD FEB PY 2009 VL 135 IS 2 BP 554 EP 557 DI 10.1378/chest.08-2224 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 405VH UT WOS:000263251800045 PM 19201720 ER PT J AU Clifton, GT Peoples, GE AF Clifton, Guy T. Peoples, George E. TI Overcoming Cancer Immune Tolerance and Escape SO CLINICAL CANCER RESEARCH LA English DT Editorial Material ID LISTERIA; VACCINE; HER-2/NEU; DELIVERY C1 [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@amedd.army.mil NR 12 TC 6 Z9 7 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD FEB 1 PY 2009 VL 15 IS 3 BP 749 EP 751 DI 10.1158/1078-0432.CCR-08-2805 PG 3 WC Oncology SC Oncology GA 405HK UT WOS:000263213600001 PM 19188142 ER PT J AU Hurst, FP Neff, RT Falta, EM Jindal, RM Lentine, KL Swanson, JS Agodoa, LY Abbott, KC AF Hurst, Frank P. Neff, Robert T. Falta, Edward M. Jindal, Rahul M. Lentine, Krista L. Swanson, John S. Agodoa, Lawrence Y. Abbott, Kevin C. TI Incidence, Predictors, and Associated Outcomes of Prostatism after Kidney Transplantation SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ACUTE URINARY RETENTION; RENAL-TRANSPLANTATION; UNITED-STATES; UROLOGICAL COMPLICATIONS; CLINICAL PROGRESSION; NATURAL-HISTORY; HYPERPLASIA; DISEASE; RISK; FINASTERIDE AB Background and objectives: Renal transplantation is increasingly performed in elderly patients, and the incidence of benign prostatic hyperplasia (BPH) increases with age. Anuric males on dialysis may have occult BPH and not develop obstructive symptoms until urine flow is restored after transplantation. If left untreated, BPH poses a risk for numerous complications, including acute urinary retention (AUR), recurrent urinary tract infections (UTI), and renal failure. The authors hypothesized that incident BPH after renal transplantation would adversely affect allograft survival. Design, setting, participants, & measurements: Medicare claims for BPH, AUR, UTI, and prostate resection procedures (transurethral resection of the prostate; TURP) were assessed in a retrospective cohort of 23,622 adult male Medicare primary renal transplant recipients in the United States Renal Data System database who received transplants from 1 January 2000 to 31 July 2005 and followed through 31 December 2005. Results: The 3-yr incidence of BPH post-transplant was 9.7%. The incidences of AUR, UTI, and TURP after BPH diagnosis (up to 3 yr posttransplant) were 10.3%, 6.5%, and 7.3% respectively, and each was significantly associated with BPH. Cox regression analysis showed that recipient age per year, later year of transplant, and dialysis vintage were associated with incident BPH. Using Cox nonproportional hazards regression, BPH was significantly associated with renal allograft loss (including death). Conclusions: BPH is common in males after renal transplant and is independently associated with AUR, UTI, and graft loss. It is unknown whether treatment of BPH, either medical or surgical, attenuates these risks. C1 [Hurst, Frank P.] Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, Washington, DC 20307 USA. [Falta, Edward M.; Jindal, Rahul M.] Walter Reed Army Med Ctr, Organ Transplantat Serv, Washington, DC 20307 USA. [Hurst, Frank P.; Neff, Robert T.; Falta, Edward M.; Abbott, Kevin C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Lentine, Krista L.] St Louis Univ, Sch Med, Div Nephrol, Ctr Outcomes Res, St Louis, MO USA. [Swanson, John S.] Christiana Care Hlth Network, Organ Transplantat Serv, Newark, DE USA. [Agodoa, Lawrence Y.] NIDDK, NIH, Bethesda, MD USA. RP Hurst, FP (reprint author), Walter Reed Army Med Ctr, Dept Nephrol, Serv Nephrol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM frank.hurst@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 25 TC 14 Z9 17 U1 0 U2 0 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD FEB PY 2009 VL 4 IS 2 BP 329 EP 336 DI 10.2215/CJN.04370808 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 407NY UT WOS:000263372800013 PM 19176793 ER PT J AU Kuehl, WM Demchenko, Y Glebov, O Zingone, A Staudt, L Brents, L Weiss, B Barlogie, B Shaughnessy, J Bergsagel, PL AF Kuehl, W. M. Demchenko, Y. Glebov, O. Zingone, A. Staudt, L. Brents, L. Weiss, B. Barlogie, B. Shaughnessy, J. Bergsagel, P. L. TI Molecular Pathogenesis of MGUS and Multiple Myeloma SO CLINICAL LYMPHOMA & MYELOMA LA English DT Meeting Abstract C1 [Kuehl, W. M.; Demchenko, Y.; Glebov, O.; Zingone, A.; Staudt, L.; Brents, L.] NCI, Bethesda, MD 20892 USA. [Weiss, B.] Walter Reed Army Med Ctr, Washington, DC USA. [Barlogie, B.; Shaughnessy, J.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CIG MEDIA GROUP, LP PI DALLAS PA 3500 MAPLE AVENUE, STE 750, DALLAS, TX 75219-3931 USA SN 1557-9190 J9 CLIN LYMPHOMA MYELOM JI Clin. Lymphoma Myeloma PD FEB PY 2009 VL 9 BP S149 EP S149 PG 1 WC Oncology SC Oncology GA 473LB UT WOS:000268206500343 ER PT J AU Kuehl, WM Demchenko, Y Glebov, O Zingone, A Staudt, L Brents, L Weiss, B Barlogie, B Shaughnessy, J Bergsagel, L AF Kuehl, W. M. Demchenko, Y. Glebov, O. Zingone, A. Staudt, L. Brents, L. Weiss, B. Barlogie, B. Shaughnessy, J. Bergsagel, L. TI Molecular Pathogenesis of MGUS and Multiple Myeloma SO CLINICAL LYMPHOMA & MYELOMA LA English DT Meeting Abstract C1 [Kuehl, W. M.; Demchenko, Y.; Glebov, O.; Zingone, A.; Staudt, L.; Brents, L.] NCI, Bethesda, MD 20892 USA. [Weiss, B.] Walter Reed Army Med Ctr, Silver Spring, MD USA. [Barlogie, B.; Shaughnessy, J.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CIG MEDIA GROUP, LP PI DALLAS PA 3500 MAPLE AVENUE, STE 750, DALLAS, TX 75219-3931 USA SN 1557-9190 J9 CLIN LYMPHOMA MYELOM JI Clin. Lymphoma Myeloma PD FEB PY 2009 VL 9 BP S11 EP S11 PG 1 WC Oncology SC Oncology GA 472EE UT WOS:000268111400008 ER PT J AU Schlegel, KE Kao, YE Kim, SY AF Schlegel, Kevin E. Kao, Yang-En Kim, Sun Y. TI Papillary Muscle Hypertrophy Appreciated on MUGA SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE MUGA; papillary hypertrophy; cardiac ventriculography ID ENDOCARDITIS; DISEASE AB Multiple gated cardiac blood pool ventriculography was performed on a 53-year-old man with multiple myeloma. The left ventricular ejection fraction was normal but a small area of photon deficiency was present in the anterolateral left ventricular chamber. Cardiac MRI revealed slight thickenting of the left ventricular myocardium and a hypertrophied papillary muscle. C1 [Schlegel, Kevin E.; Kao, Yang-En; Kim, Sun Y.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Schlegel, KE (reprint author), Walter Reed Army Med Ctr, Dept Radiol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM kevin.schlegel@amedd.army.mil NR 11 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD FEB PY 2009 VL 34 IS 2 BP 94 EP 95 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 401CT UT WOS:000262916600011 PM 19352261 ER PT J AU Tuthill, AM White, KD Vuyovich, CM Daniels, LA AF Tuthill, A. M. White, K. D. Vuyovich, C. M. Daniels, L. A. TI Effects of proposed dam removal on ice jamming and bridge scour on the Clark Fork River, Montana SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Ice jams; Ice jam bed scour; Ice jam modeling; Dam removal; Remediation of contaminated sediment; Clark Fork River; Superfund Project AB The Milltown Dam, at the confluence of the Clark Fork and Blackfoot Rivers ill Montana, lies at the downstream end of the nation's largest Superfund Project. Since its construction in 1906, several hundred thousand tonnes of metal-contaminated sediment from upstream mining activities, primarily copper. have accumulated in the dam impoundment. A large amount of this sediment was scoured during a 1996 ice jam event on Clark Fork and Blackfoot Rivers and transported downstream. The EPA remediation plan calls for phased removal and off-site disposal of much of the contaminated sediment. and removal of the Milltown Dam and a smaller mill dam upstream on the Blackfoot River. As Much as possible, the river channels will be restored to their pre-project natural morphology. This study assessed ice impacts associated with the restoration plan. specifically where ice jams and related ice jam Scour might occur with and without the dams in place. Also addressed was the effect of dam removal on potential ice-related scour around the piers of five bridges that cross the Blackfoot River just upstream of the Milltown Dam. Because this type of problem is relatively new, relevant engineering guidelines are lacking. Shortcomings of the tools and methods used are discussed. It is hoped that the study described herein will assist those addressing similar problems in the future, and also point to areas where analysis methods and tools could be improved. Published by Elsevier B.V. C1 [Tuthill, A. M.; White, K. D.; Vuyovich, C. M.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Daniels, L. A.] USA, Corps Engineers, Missoula Business Off, Missoula, MT 59801 USA. RP Tuthill, AM (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Andrew.M.Tuthill@erdc.usace.army.mil FU Missoula, MT; Business Office of the US Army Corps of Engineers. Seattle District FX This study was supported by the Missoula, MT, Business Office of the US Army Corps of Engineers. Seattle District. The ice evaluation is a component of the larger EPA effort to remediate contaminated sediment in the Clark Fork River. NR 23 TC 1 Z9 1 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD FEB PY 2009 VL 55 IS 2 BP 186 EP 194 DI 10.1016/j.coldregions.2008.09.004 PG 9 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 399LP UT WOS:000262801700002 ER PT J AU Ettema, R Kirkil, G Daly, S AF Ettema, Robert Kirkil, Gokhan Daly, Steven TI Frazil ice concerns for channels, pump-lines, penstocks, siphons, and tunnels in mountainous regions SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Frazil ice; Rivers; Hydropower; Tunnels; Pumps ID FREEZE-ON MECHANISM; RICH BASAL ICE AB This paper discusses frazil ice concerns associated with water-conveyance systems located in mountainous regions. Such systems commonly comprise open-water channels (or reservoirs) linked to pressurized conduits (pump-lines, penstocks, siphons, and tunnels) that pass water down, up, over. or through steep terrain. The discussion addresses fundamental aspects of frazil formation and behavior in flows undergoing Substantial pressure changes. An important consideration for such flows is that increased pressure depresses the freezing temperature of water. As flow pressure subsequently decreases (e.g.. on passing through a turbine, or rising up a pump-line), water may become supercooled and prone to form frazil. The melting of ice entering a pressurized conduit (e.g., a penstock) call cool water flowing through the conduit. Such cooling may occur even when there is no heat loss through the conduit's wall. It is well known that water-conveyance systems in cold regions are prone to significant frazil-blockage problems at entrance trash-racks. Less well known, however, are that some pressurized conduits also are at risk of accumulating frazil within themselves, and others may disgorge bolus accumulations of frazil, possibly mixed with other ice, that then create blockage problems at a downstream section. Several case-studies are used to illustrate situations where frazil has posed problems for penstocks, siphons, and tunnels in mountainous regions. (C) 2008 Elsevier B.V. All rights reserved. C1 [Ettema, Robert] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 83072 USA. [Kirkil, Gokhan] Univ Iowa, Dept Civil & Environm Engn, Iowa City, IA 52242 USA. [Daly, Steven] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Ettema, R (reprint author), Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 83072 USA. EM rettema@uwyo.edu; gokhan-kirkil@uiowa.edu; Steven.F.Daly@erdc.usace.army.mil RI Kirkil, Gokhan/D-8481-2014 NR 18 TC 7 Z9 7 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD FEB PY 2009 VL 55 IS 2 BP 202 EP 211 DI 10.1016/j.coldregions.2008.04.008 PG 10 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 399LP UT WOS:000262801700004 ER PT J AU Leconte, R Daly, S Gauthier, Y Yankielun, N Berube, F Bernier, M AF Leconte, R. Daly, S. Gauthier, Y. Yankielun, N. Berube, F. Bernier, M. TI A controlled experiment to retrieve freshwater ice characteristics from an FM-CW radar system SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Freshwater ice; Radar; Laboratory experiment; Ice thickness ID SUB-ARCTIC LAKES; BACKSCATTER CHARACTERISTICS; RIVER ICE; THICKNESS; MANITOBA AB A controlled experiment was conducted at the Cold Re ion Research and Engineering Laboratory (CRREL) facilities for retrieving freshwater ice characteristics using a Frequency Modulated Continuous Wave (FM-CW) radar system. The purpose of this Study is to quantify the interactions between a backscattered radar signal and ice cover characteristics such as thickness and air bubble content: and to provide a comprehensive data set for testing a theoretical radar backscattering model currently under development. The experiment was held in an indoor test basin (36.5 mx9.4 mx2.5 m), where an ice sheet was grown from 0 to 24 cm thickness and monitored with a series of radar and geophysical measurements. Backscattering of the ice cover using an in-house FM-CW C-band radar was repeatedly measured at incidence angles varying from 0 to 50 degrees for four polarisation combinations, HH, VV, HV. and VH. Ancillary data. such as ice thickness, crystalline structure and air bubble content, air temperature and hoarfrost water equivalent were collected to support the analysis and interpretation of the radar data. Analysis of the radar backscattered signal indicates that the received power is notably affected by ice thickness. For example. the HH/HV ratio of power signals cot-related with ice thickness between 8 and 24 cm with R 2 value ranging from 0.75 to 0.90. It was shown through modeling of the radar reflectivity that the lack of correlation at less than 8 cm was caused by the coherent addition of the multiple reflections at the air/ice and the ice/water boundaries. These results are encouraging as for the potential of retrieving lake and river ice thickness from satellite SAR sensors operating at C-band frequencies and at 20 to 50 degrees incidence angles, such as Radarsat 1 and 2 and Envisat, although their current radiometric resolution may limit ice thickness retrieval to thicker ice covers. Also, a number of unresolved issues must be addressed before taking full advantage of these sensors for operational retrieving of freshwater ice thickness. For one, additional controlled experiments must be carried out with ice covers embracing a range of surface roughness values. Ice covers with more diversified air inclusions and snow cover characteristics also need to be investigated, which probably can be best done by deploying radar systems next to natural ice covers. (C) 2008 Elsevier B.V. All rights reserved. C1 [Leconte, R.] Ecole Technol Super, Montreal, PQ H3C 1K3, Canada. [Daly, S.; Yankielun, N.] USA, Ctr Res & Dev, Cold Reg Res & Engn Lab, Hanover, NH 03779 USA. [Gauthier, Y.; Berube, F.; Bernier, M.] Ctr Eau Terre & Environm, Inst Natl Rech Sci, Quebec City, PQ G1K 9A9, Canada. RP Leconte, R (reprint author), Ecole Technol Super, 1100 Rue Notre Dame Ouest, Montreal, PQ H3C 1K3, Canada. EM robert.leconte@estmtl.ca FU Canadian Networks of Centres of Excellence FX This work was funded by the Canadian Networks of Centres of Excellence program through the Geoide Network. The Cold Regions and Research Engineering Laboratory generously provided infrastructure Support. Contributors at CRREL include Nancy Perron, thin section preparation and imaging; William Burch and Christopher Donnelly, radar mounting apparatus design and construction; Jesse Stanley and Nathan Lamie, technical support; and Leonard Zabilansky, facilities management. The authors also wish to thank Dr. Steve Arcone, of CRREL, and one anonymous reviewer for the helpful suggestions which helped improve this manuscript. NR 25 TC 10 Z9 11 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD FEB PY 2009 VL 55 IS 2 BP 212 EP 220 DI 10.1016/j.coldregions.2008.04.003 PG 9 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA 399LP UT WOS:000262801700005 ER PT J AU Edwards, JD Bower, KS Brooks, DB Walter, A AF Edwards, Jayson D. Bower, Kraig S. Brooks, Dain B. Walter, Angela TI Fabry Disease and Chemosis SO CORNEA LA English DT Article DE Fabry disease; chemosis; anterior segment fluorescein angiography ID ENZYME REPLACEMENT THERAPY; OCULAR MANIFESTATIONS; CORNEA AB Purpose: To report the case of it patient with Fabry disease (ED) whose ocular presentation with chronic chemosis we feel is related to ED and to describe the conjunctival fluorescein angiographic findings. Methods: A 51-year-old male patient with FD on enzyme replacement therapy presented with 1-month chemosis and mild irritation in the left eye. Ocular examination revealed pronounced noninflammatory chemosis inferotemporally in the left eye with Conjunctival tortuosity and microaneurysms bilaterally. There was mild corneal verticillata. spoke-like lens opacities, and retinal vascular tortuosity bilaterally, with no evidence of disc or macular edema. Evaluation revealed no systemic cause for his chemosis.. including an orbital computerized tomography scan, which showed clear sinuses and no evidence of all intraorbital mass. Results: Conjunctival fluorescein angiography revealed rapid subconjunctival accumulation of dye in the involved eye but failed to demonstrate leakage from tortuous conjunctival vessels or microaneurysms. Conclusions: Although the pathology of chronic chemosis ill patients with FD is as yet unknown, we believe that FD Should be considered in the differential diagnosis of patients presenting with chronic chemosis Of unknown etiology. C1 [Edwards, Jayson D.] Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Washington, DC 20307 USA. [Brooks, Dain B.] Bayne Jones Army Community Hosp, Ophthalmol Serv, Ft Folk, LA USA. [Walter, Angela] Genzyme Corp, Cambridge, MA USA. RP Edwards, JD (reprint author), Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Room 2F-200,6900 Georgia Ave, Washington, DC 20307 USA. EM jayson.edwards@amedd.army.mil NR 22 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-3740 J9 CORNEA JI Cornea PD FEB PY 2009 VL 28 IS 2 BP 224 EP 227 PG 4 WC Ophthalmology SC Ophthalmology GA 400BX UT WOS:000262844100022 PM 19158572 ER PT J AU Luria, RB Conologue, T AF Luria, Rebecca B. Conologue, Theresa TI Atrophoderma Vermiculatum: A Case Report and Review of the Literature on Keratosis Pilaris Atrophicans SO CUTIS LA English DT Review ID ULERYTHEMA-OPHRYOGENES; ASSOCIATION; 18P AB This article has been poor reviewed and approved by Michael Fisher, MD, Professor of Medicine, Albert Einstein College of Medicine. Review date: January 2009. This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Albert Einstein College of Medicine and Quadrant HealthCom, Inc. Albert Einstein College of Medicine is accredited by the ACCME to provide continuing medical education for physicians. Albert Einstein College of Medicine designates this educational activity for a maximum of 1 AMA PRA Category I Credit (TM), Physicians should only claim credit commensurate with the extent of their participation in the activity. This activity has been planned and produced in accordance with ACCME Essentials. C1 [Luria, Rebecca B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Luria, RB (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM rluria@usuhs.mil NR 22 TC 9 Z9 11 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD FEB PY 2009 VL 83 IS 2 BP 83 EP 86 PG 4 WC Dermatology SC Dermatology GA 412SL UT WOS:000263744400007 PM 19326693 ER PT J AU Du, K Rood, MJ Kim, BJ Kemme, MR Franek, B Mattison, K AF Du, Ke Rood, Mark J. Kim, Byung J. Kemme, Michael R. Franek, Bill Mattison, Kevin TI Evaluation of Digital Optical Method To Determine Plume Opacity during Nighttime SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ATMOSPHERE AB United States Environmental Protection Agency (USEPA) set opacity standards for visual emissions from industrial sources to protect ambient air quality. USEPA developed Method 9, which is a reference method to describe how plume opacity can be quantified by human observers during daytime conditions. However, it would be beneficial to determine plume opacity with digital still cameras (DSCs) to provide graphical records of the plume and its environment during visual emission evaluation and to be able to determine plume opacity with DSCs during nighttime conditions. Digital optical method (DOM) was developed to quantify plume opacity from photographs that were provided by a DSC during daytime. Past daytime field campaigns have demonstrated that DOM provided opacity readings that met Method 9 certification requirements. In this paper, the principles and methodology of DOM to quantify plume opacity during nighttime are described. Also, results are described from a nighttime field campaign that occurred at Springfield, IL Opacity readings provided by DOM were compared with the opacity values obtained with the reference in-stack transmissometer of the smoke generator. The average opacity errors were 2.3-3.5% for contrast model of DOM for all levels of plume opacity. The average opacity errors were 2.0-7.6% for the transmission model of DOM for plumes with opacity 0-50%. These results are encouraging and indicate that DOM has the potential to quantify plume opacity during nighttime. C1 [Du, Ke; Rood, Mark J.] Univ Illinois, Urbana, IL 61801 USA. [Kim, Byung J.; Kemme, Michael R.] USA, ERDC, CERL, Champaign, IL USA. [Franek, Bill; Mattison, Kevin] Illinois Environm Protect Agcy, Des Plaines, IL USA. RP Rood, MJ (reprint author), Univ Illinois, Urbana, IL 61801 USA. EM mrood@illinois.edu RI Du, Ke/A-6649-2012 FU Department of Defense with contracts Army [W9132T-05-2-0022, W9132T-08-2-0003] FX Financial support is acknowledged from the Department of Defense with contracts Army W9132T-05-2-0022 and Army W9132T-08-2-0003. NR 15 TC 3 Z9 3 U1 2 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 1 PY 2009 VL 43 IS 3 BP 783 EP 789 DI 10.1021/es800483x PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 401FX UT WOS:000262926400043 PM 19245017 ER PT J AU Hilakivi-Clarke, L Yu, W Cline, M Rodriguez, GC Maxwell, GL AF Hilakivi-Clarke, L. Yu, W. Cline, M. Rodriguez, G. C. Maxwell, G. L. TI Dietary vitamin D exposure reverses the effects of obesity-inducing high-fat diet on premalignant and malignant endometrial changes in Pten+/- mice SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Hilakivi-Clarke, L.; Yu, W.] Georgetown Univ, Dept Oncol, Washington, DC USA. [Cline, M.] Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Winston Salem, NC 27103 USA. [Rodriguez, G. C.] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. [Maxwell, G. L.] Walter Reed Army Med Ctr, Gynecol Dis Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD FEB PY 2009 VL 112 IS 2 MA 25 BP S14 EP S14 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 419OY UT WOS:000264230200026 ER PT J AU Levin, AO Carpenter, KM Brothers, B Andersen, BL Maxwell, GL Fowler, JM AF Levin, A. O. Carpenter, K. M. Brothers, B. Andersen, B. L. Maxwell, G. L. Fowler, J. M. TI Sexual morbidity as a risk factor for poorer quality of life and psychological outcomes in gynecologic cancer SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Levin, A. O.; Brothers, B.; Andersen, B. L.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA. [Carpenter, K. M.] Univ Calif Los Angeles, Div Canc Prevent & Control Res, Los Angeles, CA USA. [Maxwell, G. L.] Walter Reed Army Med Ctr, Div Gynecol Oncol, Bethesda, MD USA. [Fowler, J. M.] Ohio State Univ, James Canc Ctr, Columbus, OH 43210 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD FEB PY 2009 VL 112 IS 2 MA 66 BP S35 EP S36 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 419OY UT WOS:000264230200067 ER PT J AU Stany, MP Bidus, MA Dainty, LA Krivak, TC McHale, MT Winter, WE Tedjarati, SS Bieber, A Berek, JS Rose, GS Elkas, JC AF Stany, M. P. Bidus, M. A. Dainty, L. A. Krivak, T. C. McHale, M. T. Winter, W. E. Tedjarati, S. S. Bieber, A. Berek, J. S. Rose, G. S. Elkas, J. C. TI Does early treatment with platinum improve survival in patients with platinum-resistant ovarian cancer? SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Stany, M. P.; Rose, G. S.] Walter Reed Army Med Ctr, Dept Gynecol Oncol, Washington, DC 20307 USA. [Bidus, M. A.] Portsmouth Naval Hosp, Dept Gynecol Oncol, Portsmouth, Hants, England. [Dainty, L. A.] Madigan Army Med Ctr, Dept Gynecol Oncol, Tacoma, WA 98431 USA. [Krivak, T. C.] Magee Womens Hosp, Dept Gynecol Oncol, Pittsburgh, PA USA. [McHale, M. T.] Univ Calif San Diego, Dept Gynecol Oncol, Moores Canc Ctr, La Jolla, CA 92093 USA. [Winter, W. E.] NW Canc Specialists, Dept Gynecol Oncol & Pelv Surg, Portland, OR USA. [Tedjarati, S. S.] Texas Tech Univ, Dept Gynecol Oncol, Hlth Sci Ctr, Amarillo, TX USA. [Bieber, A.; Elkas, J. C.] No Virginia Pelv Surg Associate PC, Fairfax, VA USA. [Berek, J. S.] Stanford Univ, Dept Gynecol Oncol, Palo Alto, CA 94304 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD FEB PY 2009 VL 112 IS 2 MA 246 BP S125 EP S126 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 419OY UT WOS:000264230200245 ER PT J AU Zhang, QC Jonas, C O'Loughlin, M Callanan, R Agarwal, A Scozzie, C AF Zhang, Qingchun Jonas, Charlotte O'Loughlin, Michael Callanan, Robert Agarwal, Anant Scozzie, Charles TI A 10-kV Monolithic Darlington Transistor With beta(forced) of 336 in 4H-SiC SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Bipolar junction transistors (BJTs); BVCBO; BVCEO; current gain; Darlington transistor; silicon carbide ID BIPOLAR-JUNCTION-TRANSISTORS; CURRENT GAIN AB 4H-SiC bipolar Darlington transistors with a record-high current gain have been demonstrated. The de forced current gain was measured up to 336 at 200 W/cm(2) (J(C) = 35 A/cm(2) at V-CE = 5.7 V) at room temperature. The current gain exhibits a negative temperature coefficient and remains as high as 135 at 200 degrees C. The specific on-resistance is 140 M Omega . cm(2) at room temperature and increases at elevated temperatures. An open-emitter breakdown voltage (BVCBO) of 10 kV was achieved at a leakage current density of < 1 mA/cm(2). The device exhibits an open-base breakdown voltage (BVCEO) of 9.5 kV. The high current gain of SiC Darlington transistors can significantly reduce the gate-drive power consumption with the same forward-voltage drop as that of 10-kV SiC bipolar junction transistors, thus making the device attractive for high-power high-temperature applications. C1 [Zhang, Qingchun; Jonas, Charlotte; O'Loughlin, Michael; Callanan, Robert; Agarwal, Anant] Cree Inc, Res Triangle Pk, NC 27709 USA. [Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, QC (reprint author), Cree Inc, Res Triangle Pk, NC 27709 USA. EM Jon_Zhang@cree.com; Charlotte_Jonas@cree.com; michael_oloughlin@cree.com; Robert_Callanan@cree.com; anant_agarwal@cree.com; sscozzie@arl.army.mil FU Army Research Laboratory, Adelphi, MD [W911NF-04-2-0022] FX This work was supported by the Cooperative Agreement W911NF-04-2-0022 Program funded by the Army Research Laboratory, Adelphi, MD. The review of this letter was arranged by Editor J. K. 0. Sin. NR 8 TC 7 Z9 7 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD FEB PY 2009 VL 30 IS 2 BP 142 EP 144 DI 10.1109/LED.2008.2009953 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 400IP UT WOS:000262861600015 ER PT J AU Gani, A Gribok, AV Rajaraman, S Ward, WK Reifman, J AF Gani, Adiwinata Gribok, Andrei V. Rajaraman, Srinivasan Ward, W. Kenneth Reifman, Jaques TI Predicting Subcutaneous Glucose Concentration in Humans: Data-Driven Glucose Modeling SO IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING LA English DT Article DE Diabetes; glucose regulation; inverse problems; mathematical model; prediction; regularization; system identification ID MATHEMATICAL-MODELS; BLOOD AB The combination of predictive data-driven models with frequent glucose measurements may provide for an early warning of impending glucose excursions and proactive regulatory interventions for diabetes patients. However, from a modeling perspective, before the benefits of such a strategy can be attained, we must first be able to quantitatively characterize the behavior of the model coefficients as well as the model predictions as a function of prediction horizon. We need to determine if the model coefficients reflect viable physiologic dependencies of the individual glycemic measurements and whether the model is stable with respect to small changes in noise levels, leading to accurate near-future predictions with negligible time lag. We assessed the behavior of linear autoregressive data-driven models developed under three possible modeling scenarios, using continuous glucose measurements of nine subjects collected on a minute-by-minute basis for approximately 5 days. Simulation results indicated that stable and accurate models for near-future glycemic predictions (<60 min) with clinically acceptable time lags are attained only when the raw glucose measurements are smoothed and the model coefficients are regularized. This study provides a starting point for further needed investigations before real-time deployment can be considered. C1 [Gani, Adiwinata; Gribok, Andrei V.; Rajaraman, Srinivasan; Reifman, Jaques] USA, Med Res & Mat Command, Bioinformat Cell Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Gribok, Andrei V.] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA. [Ward, W. Kenneth] ISense Corp, Wilsonville, OR 97070 USA. [Ward, W. Kenneth] Oregon Hlth & Sci Univ, Portland, OR 97239 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, Bioinformat Cell Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM agani@ucla.edu; agribok@bioanalysis.org; srini@bioanalysis.org; kward@isensecorp.com; Jaques.reifman@us.army.mil FU Telemedicine and Advanced Technology Research Center; U.S. Army Medical Research and Materiel Command, Fort Detrick, MD; U.S. Army Medical Department, Advanced Medical Technology Initiative FX This work was supported by the Telemedicine and Advanced Technology Research Center of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, under the U.S. Army Medical Department, Advanced Medical Technology Initiative. NR 20 TC 46 Z9 48 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9294 J9 IEEE T BIO-MED ENG JI IEEE Trans. Biomed. Eng. PD FEB PY 2009 VL 56 IS 2 BP 246 EP 254 DI 10.1109/TBME.2008.2005937 PG 9 WC Engineering, Biomedical SC Engineering GA 435VZ UT WOS:000265372700007 PM 19272928 ER PT J AU Cox, GW Hughes, WE Etzkorn, LH Weisskopf, ME AF Cox, Glenn W. Hughes, William E., Jr. Etzkorn, Letha H. Weisskopf, Mary Ellen TI Predicting Computer Science Ph.D. Completion: A Case Study SO IEEE TRANSACTIONS ON EDUCATION LA English DT Article DE Computer science; factors affecting graduation; Ph.D. program; statistical analysis AB This paper presents the results of an analysis of indicators that can be used to predict whether a student will succeed in a Computer Science Ph.D. program. The analysis was conducted by studying the records of 75 students who have been in the Computer Science Ph.D. program of the University of Alabama in Huntsville. Seventy-seven variables were extracted from each student's record, and the variables were correlated with whether the student did or did not successfully graduate from the program. A multivariate model was developed that predicts success with a high degree of accuracy. Importantly, the model relies on variables that can be determined reasonably early in a student's Ph.D. class work, enabling its use as a selection metric. Hypotheses about the composition of the model are also presented and discussed. C1 [Cox, Glenn W.; Etzkorn, Letha H.; Weisskopf, Mary Ellen] Univ Alabama, Dept Comp Sci, Huntsville, AL 35899 USA. [Hughes, William E., Jr.] USASMDC, Tech Interoperabil & Matrix Ctr, Huntsville, AL 35999 USA. RP Cox, GW (reprint author), Univ Alabama, Dept Comp Sci, Huntsville, AL 35899 USA. EM gcox@c8.uah.edu NR 9 TC 3 Z9 3 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9359 J9 IEEE T EDUC JI IEEE Trans. Educ. PD FEB PY 2009 VL 52 IS 1 BP 137 EP 143 DI 10.1109/TE.2008.921458 PG 7 WC Education, Scientific Disciplines; Engineering, Electrical & Electronic SC Education & Educational Research; Engineering GA 405LD UT WOS:000263225300018 ER PT J AU Anandkumar, A Tong, L Swami, A AF Anandkumar, Animashree Tong, Lang Swami, Ananthram TI Detection of Gauss-Markov Random Fields With Nearest-Neighbor Dependency SO IEEE TRANSACTIONS ON INFORMATION THEORY LA English DT Article DE Detection and estimation; error exponent; Gauss-Markov random fields; law of large numbers ID HYPOTHESIS-TESTING PROBLEM; LARGE DEVIATIONS; COMPUTATIONAL GEOMETRY; INVERSION ALGORITHMS; STOCHASTIC-PROCESSES; QUADRATIC-FORMS; ERROR EXPONENT; GRAPHS; MATRICES; NOISE AB The problem of hypothesis testing against independence for a Gauss-Markov random field (GMRF) is analyzed. Assuming an acyclic dependency graph, an expression for the log-likelihood ratio of detection is derived. Assuming random placement of nodes over a large region according to the Poisson or uniform distribution and nearest-neighbor dependency graph, the error exponent of the Neyman-Pearson detector is derived using large-deviations theory. The error exponent is expressed as a dependency-graph functional and the limit is evaluated through a special law of large numbers for stabilizing graph functionals. The exponent is analyzed for different values of the variance ratio and correlation. It is found that a more correlated GMRF has a higher exponent at low values of the variance ratio whereas the situation is reversed at high values of the variance ratio. C1 [Anandkumar, Animashree; Tong, Lang] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Anandkumar, A (reprint author), Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. EM aa332@ece.cornell.edu; ltong@ece.cornell.edu; a.swami@ieee.org FU U.S. Army Research Laboratory [DAAD19-01-2-0011]; Army Research Office [ARO-W911NF-06-1-0346] FX This work was supported in part through the collaborative participation in the Communications and Networks Consortium sponsored by the U.S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011 and by the Army Research Office under Grant ARO-W911NF-06-1-0346. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation thereon. The material in this paper was presented in part at IEEE International Conference on Acoustics, Speech and Signal Processing, Hawaii, April 2007. NR 52 TC 23 Z9 23 U1 3 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9448 J9 IEEE T INFORM THEORY JI IEEE Trans. Inf. Theory PD FEB PY 2009 VL 55 IS 2 BP 816 EP 827 DI 10.1109/TIT.2008.2009855 PG 12 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 407OZ UT WOS:000263375500025 ER PT J AU Chen, YX Zhao, Q Swami, A AF Chen, Yunxia Zhao, Qing Swami, Ananthram TI Distributed Spectrum Sensing and Access in Cognitive Radio Networks With Energy Constraint SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Cognitive radio; opportunistic spectrum access; partially observable Markov decision process (POMDP); spectrum sensing AB We design distributed spectrum sensing and access strategies for opportunistic spectrum access (OSA) under an energy constraint on secondary users. Both the continuous and the bursty traffic models art, considered for different applications of the secondary network. In each slot, a secondary user sequentially decides whether to sense, where in the spectrum to sense, and whether to access. By casting this sequential decision-making problem in the framework of partially observable Markov decision processes, we obtain stationary optimal spectrum sensing and access policies that maximize the throughput of the secondary user during its battery lifetime. We also establish threshold structures of the optimal policies and study the fundamental tradeoffs involved in the energy-constrained OSA design. Numerical results tire provided to investigate the impact of the secondary user's residual energy on the optimal spectrum sensing and access decisions. C1 [Chen, Yunxia; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, YX (reprint author), Cisco Syst Inc, San Jose, CA 95134 USA. EM yxchen@ece.ucdavis.edu; qzhao@ece.ucdavis.edu; aswami@arl.army.mil FU Army Research Laboratory CTA on Communication and Networks [DAAD19-01-2-0011]; National Science Foundation [CNS-0627090, ECS-0622200] FX Manuscript received October 31, 2007: revised August 21. 2008. First published October 31, 2008; Current version published January 30, 2009. The associate editor coordinating the review of this manuscript and approving it tor publication was Dr. Mats Bengtsson. This work was supported in part by the Army Research Laboratory CTA on Communication and Networks under (Grant DAAD19-01-2-0011 and by the National Science Foundation under Grants CNS-0627090 and ECS-0622200. This work was presented in part at the IEEE MILCOM Conference, Washington DC, October November, 2006, and in the IEEE Global Telecommunications (GLOBECOM) Conference, Washington DC, November 2007. NR 24 TC 81 Z9 88 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD FEB PY 2009 VL 57 IS 2 BP 783 EP 797 DI 10.1109/TSP.2008.2007928 PG 15 WC Engineering, Electrical & Electronic SC Engineering GA 404OB UT WOS:000263161500031 ER PT J AU Yong, YK Patel, M Vig, J Ballato, A AF Yong, Yook-Kong Patel, Mihir Vig, John Ballato, Arthur TI Effects of Electromagnetic Radiation on the Q of Quartz Resonators SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article AB The quartz resonator Q with aluminum electrodes was studied with respect to its fundamental thickness shear mode frequency and its viscoelastic, viscopiezoelectric, and viscopiezoelectromagnetic behaviors. The governing equations for viscoelasticity, viscopiezoelectricity, and viscopiezo-electromagnetism were implemented for an AT-cut quartz resonator. To simulate the radiation conditions at infinity for the viscopiezoelectromagnetic model, perfectly matched layers over a surface enclosing the resonator were implemented to absorb all incident electromagnetic radiation. The shape of the radiation spectrum of a 5.6 MHz AT-cut quartz resonator was found to compare relatively well the measured results by Campbell and Weber. The mesa-plate resonator was studied for a frequency range of 1.4 GHz to 3.4 GHz. The resonator Q was determined to be influenced predominantly by the quartz viscoelasticity; however at frequencies greater than 2.3 GHz, the quartz electromagnetic radiation had an increasingly significant effect on the resonator Q. At 3.4 CHz, the elect romagnetic radiation accounted for about 14% of the loss in resonator Q. At frequencies less than 2 GHz, the calculated resonator Q compared well with the intrinsic Q(x) provided by the formula Q(x) = 16 X 10(6)/f where f was in MHz. At frequencies higher than 2.3 GHz, the aluminum electrodes had significant effects on the resonator Q. At 3.4 GHz, the electromagnetic radiation loss in the electrodes was an order of magnitude greater than their viscoelastic loss; hence, the vibrating aluminum electrodes became an efficient emitter of electroniagnetic waves. The effects of electrical resistance in both the electrodes and quartz were determined to be negligible. C1 [Yong, Yook-Kong; Patel, Mihir] Rutgers State Univ, Dept Civil & Environm Engn, Piscataway, NJ 08854 USA. [Vig, John] Syst Planning Corp, Arlington, VA USA. [Ballato, Arthur] USA, Commun Elect Res Dev & Engn Ctr, Ft Monmouth, NJ USA. RP Yong, YK (reprint author), Rutgers State Univ, Dept Civil & Environm Engn, Piscataway, NJ 08854 USA. EM yyong@rci.rutgers.edu OI Vig, John/0000-0002-2378-0113 NR 12 TC 2 Z9 2 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD FEB PY 2009 VL 56 IS 2 BP 353 EP 360 DI 10.1109/TUFFC.2009.1044 PG 8 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 398ED UT WOS:000262714500015 PM 19251522 ER PT J AU Zajic, AG Stuber, GL Pratt, TG Nguyen, ST AF Zajic, Alenka G. Stuber, Gordon L. Pratt, Thomas G. Nguyen, Son T. TI Wideband MIMO Mobile-to-Mobile Channels: Geometry-Based Statistical Modeling With Experimental Verification SO IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY LA English DT Article DE Channel sounding; mobile-to-mobile (M-to-M) channels; parameter estimation; wideband channel model ID POWER AB A 3-D reference model for wideband multiple-input multiple-output (MIMO) mobile-to-mobile (M-to-M) channels is reviewed along with its corresponding first- and second-order channel statistics. To validate the reference model, an experimental MIMO M-to-M channel-sounding campaign was conducted for M-to-M vehicular communication with vehicles that travel along surface streets and expressways in a metropolitan area. To compare the first- and second-order channel statistics that were obtained from the reference model with those obtained from the empirical measurements, a new maximum-likelihood-based stochastic estimator is derived to extract the relevant model parameters from the measured data. The measured data is processed and compared with the analytical results. The close agreement between the analytically and empirically obtained channel statistics confirms the utility of the proposed reference model and the method for estimating the model parameters. C1 [Zajic, Alenka G.] Georgia Inst Technol, Sch Elect & Comp Engn, Wireless Syst Lab, Atlanta, GA 30332 USA. [Pratt, Thomas G.; Nguyen, Son T.] Georgia Inst Technol, Georgia Tech Res Inst, Software Radio Lab, Atlanta, GA 30332 USA. [Nguyen, Son T.] Army Res Lab, Adelphi, MD 20783 USA. RP Zajic, AG (reprint author), Georgia Inst Technol, Sch Elect & Comp Engn, Wireless Syst Lab, Atlanta, GA 30332 USA. EM alenka@ece.gatech.edu; stuber@ece.gatech.edu; Thomas.Pratt@gtri.gatech.edu FU U.S. Army Research Laboratory [DAAD19-01-2-0011] FX Manuscript received January 10, 2008; revised April 25, 2008 and June 1, 2008. First published June 7, 2008; current version published February 17, 2009. This work was prepared through collaborative participation ill the Collaborative-Technology Alliance for Communications and Networks sponsored by the U.S. Army Research Laboratory under Cooperative Agreement DAAD19-01-2-0011. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose, notwithstanding any copyright notation thereon. The view, and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The review of this paper was coordinated by Dr. R. Qiu. NR 24 TC 58 Z9 58 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9545 J9 IEEE T VEH TECHNOL JI IEEE Trans. Veh. Technol. PD FEB PY 2009 VL 58 IS 2 BP 517 EP 534 DI 10.1109/TVT.2008.928001 PG 18 WC Engineering, Electrical & Electronic; Telecommunications; Transportation Science & Technology SC Engineering; Telecommunications; Transportation GA 411HE UT WOS:000263639300002 ER PT J AU Ezzell, JW Abshire, TG Panchal, R Chabot, D Bavari, S Leffel, EK Purcell, B Friedlander, AM Ribot, WJ AF Ezzell, J. W. Abshire, T. G. Panchal, R. Chabot, D. Bavari, S. Leffel, E. K. Purcell, B. Friedlander, A. M. Ribot, W. J. TI Association of Bacillus anthracis Capsule with Lethal Toxin during Experimental Infection SO INFECTION AND IMMUNITY LA English DT Article ID PROTECTIVE ANTIGEN; MONOCLONAL-ANTIBODIES; ADENYLATE-CYCLASE; MOLECULAR-CLONING; KINASE-KINASE; EDEMA FACTOR; IN-VITRO; PLASMID; CELLS; GENE AB Bacillus anthracis lethal toxin ( LT) was characterized in plasma from infected African Green monkeys, rabbits, and guinea pigs. In all cases, during the terminal phase of infection only the protease-activated 63-kDa form of protective antigen (PA(63)) and the residual 20-kDa fragment (PA(20)) were detected in the plasma. No uncut PA with a molecular mass of 83 kDa was detected in plasma from toxemic animals during the terminal stage of infection. PA(63) was largely associated with lethal factor (LF), forming LT. Characterization of LT by Western blotting, capture enzyme-linked immunosorbent assay, and size exclusion chromatography revealed that the antiphagocytic poly-gamma-D-glutamic acid (gamma-DPGA) capsule released from B. anthracis bacilli was associated with LT in animal blood in variable amounts. While the nature of this in vivo association is not understood, we were able to determine that a portion of these LT/gamma-DPGA complexes retained LF protease activity. Our findings suggest that the in vivo LT complexes differ from in vitro-produced LT and that including gamma-DPGA when examining the effects of LT on specific immune cells in vitro may reveal novel and important roles for gamma-DPGA in anthrax pathogenesis. C1 [Ribot, W. J.] USA, Med Res Inst Infect Dis, Dept Bacteriol, Bacteriol Div, Ft Detrick, MD 21702 USA. [Ezzell, J. W.; Abshire, T. G.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Panchal, R.] USA, Med Res Inst Infect Dis, Toxinol Div, Ft Detrick, MD 21702 USA. [Leffel, E. K.] USA, Med Res Inst Infect Dis, Natl Biodef Anal & Countermeasures Ctr, Ft Detrick, MD 21702 USA. RP Ribot, WJ (reprint author), USA, Med Res Inst Infect Dis, Dept Bacteriol, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM Wilson.ribot@amedd.army.mil FU The Defense Advanced Research Projects Agency FX We thank Katheryn Kenyon for her editorial review, Stephen F. Little for providing monoclonal antibodies against PA and NR 37 TC 25 Z9 25 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD FEB PY 2009 VL 77 IS 2 BP 749 EP 755 DI 10.1128/IAI.00764-08 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 399CF UT WOS:000262777300021 PM 19064632 ER PT J AU Hebert, CG Valdes, JJ Bentley, WE AF Hebert, Colin G. Valdes, James J. Bentley, William E. TI Investigating apoptosis: Characterization and analysis of Trichoplusia ni-caspase-1 through overexpression and RNAi mediated silencing SO INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY LA English DT Article DE Caspase; Apoptosis; RNA interference; Baculovirus expression vector systems; Insect cells ID BACULOVIRUS-EXPRESSION SYSTEM; GREEN FLUORESCENT PROTEIN; PROGRAMMED CELL-DEATH; SPODOPTERA-FRUGIPERDA CASPASE-1; NUCLEAR POLYHEDROSIS-VIRUS; TRICHOPLUSIA-NI CELLS; HAMSTER OVARY CELLS; INSECT CELLS; IN-VIVO; EFFECTOR CASPASE AB In both mammals and invertebrates, caspases play a critical role in apoptosis. Although Lepidopteron caspases have been widely studied in Spodoptera frugiperda cells, this is not the case for Trichoplusia ni cells, despite their widespread use for the production of recombinant protein and differences in baculovirus infectivity between the two species. We have cloned, expressed, purified and characterized Tn-caspase-1 in several situations: in its overexpression, in silencing via RNA interference (RNAi), during baculovirus infection, and in interactions with baculovirus protein p35. Overexpression can transiently increase caspase activity in T ni (High Five (TM)) cells, while silencing results in a greater than 6-fold decrease. The reduction in caspase activity resulted in a reduction in the level of apoptosis, demonstrating the ability to affect apoptosis by modulating Tn-caspase-1. During baculovirus infection, caspase activity remains low until approximately 5 days post infection, at which point it increases dramatically, though not in those cells treated with dsRNA. Our results demonstrate that Tn-caspase-1 is presumably the principal effector caspase present in High Five cells, and that it is inhibited by baculovirus protein p35. Finally, our results indicate differences between RNAi and p35 as effector molecules for modulating caspase activity and apoptosis during cell growth and baculovirus infection. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Hebert, Colin G.; Bentley, William E.] Univ Maryland, Ctr Biosyst Res, Inst Biotechnol, College Pk, MD 20742 USA. [Hebert, Colin G.; Valdes, James J.] USA, Edgewood Chem Biol Ctr, AMSRD ECB AP B Michel E3330, Aberdeen Proving Ground, MD 21010 USA. [Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Hebert, Colin G.; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. RP Bentley, WE (reprint author), Univ Maryland, Ctr Biosyst Res, Inst Biotechnol, 5115 Plant Sci Bldg, College Pk, MD 20742 USA. EM bentley@umd.edu FU National Institutes of Health [GM70851-01] FX The authors would like to thank P.D. Friesen and his lab at the University of Wisconsin-Madison for providing the alpha-Sfcasp-1 antibody. Also D. Moser from the Cell Biology and Molecular Genetics Department at the University of Maryland for use of the flow cytometer. This work was partially supported by the National Institutes of Health (GM70851-01). NR 72 TC 15 Z9 19 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0965-1748 EI 1879-0240 J9 INSECT BIOCHEM MOLEC JI Insect Biochem. Mol. Biol. PD FEB PY 2009 VL 39 IS 2 BP 113 EP 124 DI 10.1016/j.ibmb.2008.10.009 PG 12 WC Biochemistry & Molecular Biology; Entomology SC Biochemistry & Molecular Biology; Entomology GA 425AA UT WOS:000264608200006 PM 19027856 ER PT J AU Butler, LK Ries, L Hayden, TJ Bisson, IA Wikelski, M Romero, LM AF Butler, L. K. Ries, L. Hayden, T. J. Bisson, I-A Wikelski, M. Romero, L. M. TI Physiological and demographic effects of roads on an endangered, old-growth specialist and a common generalist SO INTEGRATIVE AND COMPARATIVE BIOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Integrative-and-Comparative-Biology CY JAN 03-07, 2009 CL Boston, MA SP Soc Integrat & Comparat Biol C1 Princeton Univ, Max Planck Inst Ornitholog, Princeton, NJ 08544 USA. Tufts Univ, Medford, MA 02155 USA. Univ Maryland, Ctr Res Dev & Engn, College Pk, MD 20742 USA. EM luke.butler@tufts.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1540-7063 J9 INTEGR COMP BIOL JI Integr. Comp. Biol. PD FEB PY 2009 VL 49 BP E24 EP E24 PG 1 WC Zoology SC Zoology GA 481KL UT WOS:000268808800094 ER PT J AU Smith, LC Mendonca, MT Richardson, CS Widmaier, EP Hohmann, MG AF Smith, L. C. Mendonca, M. T. Richardson, C. S. Widmaier, E. P. Hohmann, M. G. TI Neutrophil/Lymphocyte Ratio and Stress in Three Species of Myotis: Effects of Sex, Reproductive Stage, Size-Corrected Mass and Site SO INTEGRATIVE AND COMPARATIVE BIOLOGY LA English DT Meeting Abstract CT Annual Meeting of the Society-for-Integrative-and-Comparative-Biology CY JAN 03-07, 2009 CL Boston, MA SP Soc Integrat & Comparat Biol C1 Auburn Univ, Auburn, AL 36849 USA. Boston Univ, Boston, MA 02215 USA. USA, Erdc, CERL, Washington, DC USA. EM smithl9@auburn.edu NR 0 TC 0 Z9 0 U1 1 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1540-7063 J9 INTEGR COMP BIOL JI Integr. Comp. Biol. PD FEB PY 2009 VL 49 BP E307 EP E307 PG 1 WC Zoology SC Zoology GA 481KL UT WOS:000268808801224 ER PT J AU Sun, X Liu, WN Chen, WN Templeton, D AF Sun, Xin Liu, Wenning Chen, Weinong Templeton, Douglas TI Modeling and characterization of dynamic failure of borosilicate glass under compression/shear loading SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Glass brittle failure; Multi-axial loading; Shear failure; Failure strength; Damage mode ID CONTINUUM DAMAGE MECHANICS; STONE-IMPACT RESISTANCE; SMALL STEEL SPHERES; CRACK-GROWTH; INDENTATION; SURFACES; CERAMICS; FRACTURE AB In this paper, we study the impact-induced dynamic failure of a borosilicate glass block using an integrated experimental/analytical approach. Previous experimental studies on dynamic failure of borosilicate glass have been reported by Nie et al. [Nie X, Chen WW, Sun X, Templeton DW. Dynamic failure of borosilicate glass under compression/shear loading - experiments.] Am Ceram Soc, in press.] using the split Hopkinson pressure bar (SHPB) technique. The damage growth patterns and stress histories have been reported for various glass specimen designs. In this study, we propose to use a continuum damage mechanics (CDM)-based constitutive model to describe the initial failure and subsequent stiffness reduction of glass. Explicit finite element analyses are used to simulate the glass specimen impact event. A maximum shear stress-based damage evolution law is used in describing the glass damage process under combined compression/shear loading. The impact test results are used in quantifying the critical shear stress for the borosilicate glass under examination. It is shown that with only two modeling parameters, reasonably good comparisons between the predicted and the experimentally measured failure maps can be obtained for various glass sample geometries. Comparisons between the predicted stress histories for different sample designs are also used as model validations. Published by Elsevier Ltd. C1 [Sun, Xin; Liu, Wenning] Pacific NW Natl Lab, Richland, WA 99352 USA. [Chen, Weinong] Purdue Univ, AAE Sch, W Lafayette, IN 47907 USA. [Templeton, Douglas] USA, Tank Automot Res, Ctr Dev & Engn, AMSRD TAR R, Warren, MI 48397 USA. RP Sun, X (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99352 USA. EM xin.sun@pnl.gov NR 30 TC 12 Z9 13 U1 3 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD FEB PY 2009 VL 36 IS 2 BP 226 EP 234 DI 10.1016/j.ijimpeng.2008.01.014 PG 9 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 393QC UT WOS:000262386800007 ER PT J AU Smith, TJ Montain, SJ Anderson, D Young, AJ AF Smith, Tracey J. Montain, Scott J. Anderson, Danielle Young, Andrew J. TI Plasma Amino Acid Responses After Consumption of Beverages With Varying Protein Type SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE milk protein; exercise; carbohydrate supplements ID INSULIN RESPONSES; HEALTHY-SUBJECTS; DIGESTION RATE; MILK PROTEIN; HUMANS; INGESTION; EXERCISE; NITROGEN; DIETARY; CARBOHYDRATE AB To examine how different proteins in a carbohydrate-protein beverage affect postprandial amino acid (AA), glucose, and insulin responses. Methods: Two randomized, repeated-measures experiments were performed. In one, 10 volunteers drank 3 carbohydrate-protein beverages (390 kcal, 76 g carbohydrate, It) g protein, 2 g fat) in Separate (>7 days) trial,, each differing in protein type. All drinks consisted of cocoa (4 g) and nonfat dry milk (I g) supplemented with casein (CAS), whey (WP), of a casein and whey blend (CAS-WP). Ten additional volunteers consumed the same drinks after 60 min of varying-intensity exercise (60% and 85% VO(2peak)). Blood glucose, insulin, glucose-dependent insulinotrophic polypeptide (GIP), anti AAs were measured every 15-30 min for 4 hr after beverage consumption. Results: Branched-chain AA concentrations peaked at 30 min and did not differ between beverages at rest (0.69 +/- 0.12 mmol/L) or postexercise (0.70 +/- 0.07 mmol/L). There were no significant differences between beverages with respect to initial (time 0-60) or total area under the curve (lime 0-240) for any outcome measures at rest or postexercise. Conclusion: High-carbohydrate beverages containing various proportions of milk proteins procured from a supplier to the commercial industry had no impact on AA concentration. Retrospective chemical analysis of commercial proteins showed that casein was partially hydrolyzed; therefore, consumers should carefully consider the Manufacturer (to ensure that the product contains intact protein) or other factors (i.e., cost or taste) when procuring these beverages tint their purported physiological effects. C1 [Smith, Tracey J.; Montain, Scott J.; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Anderson, Danielle] Natick Soldier Res Dev & Engn Ctr, Natick, MA USA. RP Smith, TJ (reprint author), USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 22 TC 6 Z9 6 U1 2 U2 3 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD FEB PY 2009 VL 19 IS 1 BP 1 EP 17 PG 17 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 412LM UT WOS:000263726300001 PM 19403950 ER PT J AU Fadare, O Carns, B Vos, JA Wang, SA AF Fadare, Oluwole Carns, Bhavini Vos, Jeffrey A. Wang, Sa A. TI Clinicopathologic Features Associated With Cytohistologic Noncorrelation in the Diagnosis of Cervical Dysplasia: A Study of Concurrently Obtained Samples SO INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY LA English DT Article DE cytohistologic correlation; Papanicolaou test; cervical intraepithelial neoplasia; obscuring inflammation ID INTRAEPITHELIAL NEOPLASIA; PAPANICOLAOU TEST; CANCER DETECTION; ACCURACY; SMEARS; PATHOLOGISTS; TRENDS AB On the basis of the unique Subset of our database comprising patients who received a Papanicolaou test and a cervical biopsy during the same clinic visit, clinicopathologic factors potentially associated with cytohistologic diagnostic noncorrelation in these concurrently collected samples is investigated. In the first analysis, a selected group of variables potentially associated with noncorrelation relative to the diagnosis of high-grade dysplasia were examined, whereas the second analysis was centered oil the effect of varying levels of Papanicolaou test inflammation (below the Bethesda 2001 threshold, ie, partially obscuring inflammation) oil noncorrelation regarding the overall diagnosis of dysplasia. For the latter, the overall density of neutrophilic infiltrate oil each Papanicolaou test slide was graded in a blinded fashion on a 4-tiered scale (no significant amount, Mild, moderate, and severe), followed by a comparison of correlating and noncorrelating cases at each tier. There was no overrepresentation of noncorrelating cases in severe inflammation group. Indeed, correlating and noncorrelating cases did not significantly differ at any level of inflammation. In the first analysis, correlating (n = 17) and noncorrelating (n = 17) cases did not significantly differ in patient age, number of biopsies obtained, endocervical curettage status, glandular involvement by high-grade dysplasia or frequency of background grade 1 cervical intraepithelial neoplasia. Noncorrelating cases were more likely than correlating cases to be grade 2 cervical intraepithelial neoplasia rather than grade 3 or worse (82% vs 41 %, respectively, P =.02), which is probably attributable to the absence of a basaloid proliferation ill the most Superficial layers of grade 2 lesions. Furthermore, noncorrelating cases showed a comparatively smaller percentage of submitted biopsies involved by high-grade dysplasia (52% vs 75%, respectively, P =.03), consistent with smaller extent of disease. These findings further illustrate that lesional factors are important potential contributors to the false-negative rate of the Papanicolaou test. C1 [Fadare, Oluwole; Carns, Bhavini] Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX 78236 USA. [Fadare, Oluwole] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Carns, Bhavini; Vos, Jeffrey A.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Carns, Bhavini; Vos, Jeffrey A.] Brooke Army Med Ctr, Lab Serv, Ft Sam Houston, TX 78234 USA. [Carns, Bhavini] San Antonio Uniformed Serv Hlth Educ Consortium, Pathol Program, San Antonio, TX USA. [Wang, Sa A.] Univ Massachusetts, Med Ctr, Dept Pathol, Worcester, MA USA. RP Fadare, O (reprint author), Wilford Hall USAF Med Ctr, Dept Pathol, 2200 Bergquist Dr,St 1, Lackland AFB, TX 78236 USA. EM oluwolefadare@yahoo.com FU NCI NIH HHS [P30 CA016672] NR 21 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1066-8969 J9 INT J SURG PATHOL JI Int. J. Surg. Pathol. PD FEB PY 2009 VL 17 IS 1 BP 31 EP 37 DI 10.1177/1066896908315818 PG 7 WC Pathology; Surgery SC Pathology; Surgery GA 398ZL UT WOS:000262770100005 PM 18480391 ER PT J AU Davis, TA Stojadinovic, A Anam, K Amare, M Naik, S Peoples, GE Tadaki, D Elster, EA AF Davis, Thomas A. Stojadinovic, Alexander Anam, Khairul Amare, Mihret Naik, Shruti Peoples, George E. Tadaki, Douglas Elster, Eric A. TI Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury SO INTERNATIONAL WOUND JOURNAL LA English DT Article DE Burns; Chemokines; Extracorporeal shock wave therapy; Inflammation; Wound healing AB Following severe burn injury, persistent inflammation perpetuated by surface eschar, bacterial colonisation and neutrophil proteolytic activity can impede normal healing and result in further tissue damage. Extracorporeal shock wave treatment (ESWT) has been shown in the clinical setting to promote the healing of burn and difficult-to-heal wounds; however, the mechanism is unclear. We investigated the role of ESWT on the early proinflammatory response using a severe, full-thickness and highly inflammatory cutaneous burn wound in a murine model. Various wound-healing parameters were measured and leukocyte infiltration quantitated. A panel of 188 candidate genes known to be involved in acute inflammation and wound healing was screened. We show that ESWT of burn wounds 1 hour postwounding significantly blunts polymorphonuclear neutrophil and macrophage infiltration into the wound. ESWT treatment potently attenuates both CC- and CXC-chemokine expression, acute proinflammatory cytokine expression and extracellular matrix proteolytic activity at the wound margin. Given these findings and the clinical success of ESWT, we speculate that ESWT may be a potential therapeutic modality to treat severe wounds wherein excessive inflammatory responses involving increased levels of inflammatory cells, proinflammatory cytokines and proteases may become self-resolving allowing wound healing to progresses by way of normal physiological repair processes. C1 [Davis, Thomas A.; Anam, Khairul; Amare, Mihret; Naik, Shruti; Tadaki, Douglas; Elster, Eric A.] USN, Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Combat Wound Initiat, Washington, DC 20307 USA. [Stojadinovic, Alexander; Peoples, George E.; Tadaki, Douglas; Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Combat Wound Initiat, Ft Sam Houston, TX 78234 USA. [Elster, Eric A.] Natl Naval Med Ctr, Dept Surg, Combat Wound Initiat, Bethesda, MD USA. RP Davis, TA (reprint author), USN, Med Res Ctr, Dept Regenerat Med, Room 2A10,503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM thomas.davis1@med.navy.mil FU Office of Naval Research (ONR) work unit [601153N.4508.519.A0508] FX We thank Tissue Regenerative Technologies Inc. (Woodstock, GA, USA) for the use of the DermaGold shock wave instrument. This work was supported by the Office of Naval Research (ONR) work unit 601153N.4508.519.A0508. NR 36 TC 56 Z9 60 U1 1 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1742-4801 J9 INT WOUND J JI Int. Wound J. PD FEB PY 2009 VL 6 IS 1 BP 11 EP 21 DI 10.1111/j.1742-481X.2008.00540.x PG 11 WC Dermatology; Surgery SC Dermatology; Surgery GA V16BS UT WOS:000207845700003 PM 19291111 ER PT J AU Klein, DA Gilderngorin, G Mosher, P Adelman, WR AF Klein, David A. Gilderngorin, Ginny Mosher, Peter Adelman, William R. TI BIRTHS TO ADOLESCENTS IN THE UNITED STATES MILITARY HEALTH CARE SYSTEM SO JOURNAL OF ADOLESCENT HEALTH LA English DT Meeting Abstract C1 [Adelman, William R.] Walter Reed Army Med Ctr, Dept Pediat, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2009 VL 44 IS 2 SU 1 MA 73 BP S44 EP S44 PG 1 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 406BN UT WOS:000263270100103 ER PT J AU Klein, DA Gildengorin, G Mosher, P Adelman, WP AF Klein, David A. Gildengorin, Ginny Mosher, Peter Adelman, William P. TI PROFILE OF ADOLESCENTS UNDERGOING CAESARIAN SECTION IN A UNIVERSAL HEALTH CARE SYSTEM SO JOURNAL OF ADOLESCENT HEALTH LA English DT Meeting Abstract C1 [Mosher, Peter] David Grant Med Ctr, TRICARE, Travis AFB, CA USA. [Adelman, William P.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 2009 VL 44 IS 2 MA 5 BP S5 EP S5 PG 1 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 406BN UT WOS:000263270100011 ER PT J AU Engler, RJM With, CM Gregory, PJ Jellin, JM AF Engler, Renata J. M. With, Catherine M. Gregory, Philip J. Jellin, Jeff M. TI Complementary and alternative medicine for the allergist-immunologist: Where do I start? SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE Complementary and alternative medicine; integrative medicine; herbals; herbs; adverse reactions; risk communication; quality of care ID ADVISING PATIENTS; PELARGONIUM-SIDOIDES; UNITED-STATES; COMMON COLD; THERAPIES; CURRICULUM; ANAPHYLAXIS; EDUCATION; REFLECTIONS; HEALTH AB Complementary and alternative medicine (CAM) therapies present a growing information management challenge for physicians because nearly 40% of their patients may be using and another 50% may he considering use of CAM as part of their healthcare regimen. The National Health Statistics Reports for 2007 described the most commonly used nonvitamin, nonmineral therapy as natural products (eg, herbals at 17.7%). More than 5% of children under the age of 18 years used CAM for allergic conditions including asthma. The amount and quality of information available and concerns about liability risk represent a challenge for most physicians. This review focuses on considerations for approaching a CAM-related consultation, incorporating legal and logistic factors affecting how such an encounter should be approached. A 10-step process is presented that addresses different components of (CAM consultations and what should be documented. Access to timely, high-quality information regarding product specific efficacy and safety data, as found in the Natural Medicines Comprehensive Database, is needed to support CAM consultation efficiently. Understanding of serious adverse events associated with CAM is limited; an international need exists for improved safety surveillance and information sharing. Allergy-immunology, as a specialty with expertise in adverse drug reaction evaluation and management, has a unique opportunity to support enhanced CAM-related adverse events evaluations, reporting, and research. (J Allergy Clin Immunol 2009;123:309-16. C1 [Engler, Renata J. M.] Walter Reed Army Med Ctr, Allergy Immunol Dept, Vaccine Healthcare Ctr Network, Washington, DC 20307 USA. [Engler, Renata J. M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [With, Catherine M.] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Gregory, Philip J.; Jellin, Jeff M.] Nat Med Comprehensiv Databse, Stockton, CA USA. [Jellin, Jeff M.] Pharmacists Letter & Prescribers Letter, Stockton, CA USA. [Gregory, Philip J.] Creighton Univ, Ctr Drug Informat & Evidence Based Practice, Omaha, NE 68178 USA. RP Engler, RJM (reprint author), Walter Reed Army Med Ctr, Allergy Immunol Dept, Vaccine Healthcare Ctr Network, Washington, DC 20307 USA. EM renata.engler@gmail.com FU NCCIH NIH HHS [K07 AT005463] NR 51 TC 14 Z9 14 U1 1 U2 7 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2009 VL 123 IS 2 BP 309 EP 316 DI 10.1016/j.jaci.2009.01.001 PG 8 WC Allergy; Immunology SC Allergy; Immunology GA 409GU UT WOS:000263495000003 PM 19203654 ER PT J AU Scranton, SE Gonzalez, EG Waibel, KH AF Scranton, Stephen E. Gonzalez, Erika G. Waibel, Kirk H. TI Incidence and characteristics of biphasic reactions after allergen immunotherapy SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE Anaphylaxis; biphasic; immunotherapy ID ANAPHYLACTIC REACTIONS; PREDICTORS AB Background: The reported incidence of biphasic anaphylactic reactions varies from 1% to 20%. Reported risk factors for biphasic reactions include a delay in epinephrine administration and a longer interval to initial improvement. To date, only 4 cases of biphasic reactions after allergen immunotherapy have been reported. Objective: We sought to determine the incidence, clinical characteristics, and risk factors for biphasic reactions after allergen-specific immunotherapy. Methods: Patients who were treated with epinephrine for systemic reactions after allergen immunotherapy were prospectively enrolled. Patients were assessed initially and at 24 hours by using a 31-symptom scoring system. Results: Sixty systemic reactions occurred in 55 patients; 14 (23%) biphasic reactions were reported. Patients experiencing biphasic reactions were more likely to be female (P = .03) and older (P = .01) and require greater than 1 dose of epinephrine (P = .001). There was no difference between groups (biphasic vs no biphasic reaction) regarding the type of immunotherapy, current asthma, initial symptom scores, or time to symptoms, initial epinephrine, or improvement. No specific symptom predicted biphasic reactions. Biphasic reactions were significantly less severe compared with the initial reaction (P < .001), did not occur in children, and did not require additional epinephrine. Conclusions: Twenty-three percent of patients requiring epinephrine for systemic reactions caused by allergen immunotherapy experienced biphasic symptoms. Patients treated promptly with epinephrine for systemic reactions should he cautioned regarding biphasic reactions; however, biphasic reactions after allergen immunotherapy were mild and did not require additional epinephrine. (J Allergy Clin Immunol 2009;123:493-8.) C1 [Scranton, Stephen E.] Landstuhl Reg Med Ctr, Dept Allergy & Immunol, Landstuhl, Germany. [Gonzalez, Erika G.] Wilford Hall USAF Med Ctr, Dept Allergy & Immunol, Lackland AFB, TX 78236 USA. [Waibel, Kirk H.] Brooke Army Med Ctr, Allergy Immunol Clin, Ft Sam Houston, TX 78234 USA. RP Scranton, SE (reprint author), CMR 402,Box 1448, APO, AE 09180 USA. EM scrantons@gmail.com NR 13 TC 33 Z9 33 U1 1 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2009 VL 123 IS 2 BP 493 EP 498 DI 10.1016/j.jaci.2008.10.026 PG 6 WC Allergy; Immunology SC Allergy; Immunology GA 409GU UT WOS:000263495000031 PM 19064282 ER PT J AU Engler, RJM Silvers, WS Bielory, L AF Engler, Renata J. M. Silvers, William S. Bielory, Leonard TI Complementary and alternative medicine education: Need for expanded educational resources for American Academy of Allergy, Asthma & Immunology members SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Letter C1 [Engler, Renata J. M.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Engler, Renata J. M.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Allergy Immunol Dept, Washington, DC 20307 USA. [Silvers, William S.] Univ Colorado, Sch Med, Englewood, CO USA. [Silvers, William S.] Univ Colorado, Allergy Asthma & Immunol Clin Colorado PC, Englewood, CO USA. [Bielory, Leonard] Clin Res & Dev UMDNJ New Jersey Med Sch, Dept Pediat, Div Rheumatol Allergy & Immunol, Newark, NJ USA. [Bielory, Leonard] Clin Res & Dev UMDNJ New Jersey Med Sch, UMDNJ Asthma & Allergy Res Ctr, Newark, NJ USA. RP Engler, RJM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. EM Renata.engler@gmail.com NR 8 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2009 VL 123 IS 2 BP 511 EP 512 DI 10.1016/j.jaci.2008.11.020 PG 2 WC Allergy; Immunology SC Allergy; Immunology GA 409GU UT WOS:000263495000040 PM 19203668 ER PT J AU Engler, RJM Collins, LC Gibbs, BT Hemann, BA Gates, DG Cassimatis, DC Atwood, JE Nelson, MR Spooner, CE Wilsons, CB Davis, RL AF Engler, R. J. M. Collins, L. C. Gibbs, B. T. Hemann, B. A. Gates, D. G. Cassimatis, D. C. Atwood, J. E. Nelson, M. R. Spooner, C. E. Wilsons, C. B. Davis, R. L. TI Myocarditis after Smallpox/Vaccinia Immunization: Passive Vaccine Safety Surveillance Compared to Prospective Studies SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 13-17, 2009 CL Washington, DC SP Amer Acad Allergy, Asthma & Immunol C1 [Engler, R. J. M.; Collins, L. C.; Spooner, C. E.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Washington, DC 20307 USA. [Gates, D. G.] Womack Army Med Ctr, Ft Bragg, NC USA. [Cassimatis, D. C.] Landstuhl Army Med Ctr, Landstuhl, Germany. [Wilsons, C. B.] Univ Washington, Seattle, WA 98195 USA. [Davis, R. L.] Kaiser Permanente Res, Atlanta, GA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2009 VL 123 IS 2 MA 1024 BP S264 EP S264 DI 10.1016/j.jaci.2008.12.1022 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 410RR UT WOS:000263596301496 ER PT J AU Kosisky, SE Engle, CE Marks, MS Bienlein, AB Nelson, MR AF Kosisky, S. E. Engle, C. E. Marks, M. S. Bienlein, A. B. Nelson, M. R. TI An Internet Accessible Extract Lab Management System (ELMS) Increases Efficiency and Minimizes Prescription Ordering Discrepancies in a Centralized Allergen Extract Mixing Laboratory SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 13-17, 2009 CL Washington, DC SP Amer Acad Allergy, Asthma & Immunol C1 [Kosisky, S. E.; Engle, C. E.; Marks, M. S.; Bienlein, A. B.; Nelson, M. R.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2009 VL 123 IS 2 MA 444 BP S117 EP S117 DI 10.1016/j.jaci.2008.12.430 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 410RR UT WOS:000263596300457 ER PT J AU Martin, CR Haymore, B Nelson, M McClenathan, B Johnson, J Engler, R AF Martin, C. R. Haymore, B. Nelson, M. McClenathan, B. Johnson, J. Engler, R. TI Cutaneous Reactivity to Smallpox Vaccine: Gender and Product Differences SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 13-17, 2009 CL Washington, DC SP Amer Acad Allergy, Asthma & Immunol C1 [Martin, C. R.; Haymore, B.; Nelson, M.; Engler, R.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [McClenathan, B.] Womack Army Med Ctr, Ft Bragg, NC USA. [Johnson, J.] Irwin Army Community Hosp, Ft Riley, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2009 VL 123 IS 2 MA 625 BP S163 EP S163 DI 10.1016/j.jaci.2008.12.615 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 410RR UT WOS:000263596301098 ER PT J AU Turbyville, JC Payne, K Gada, S Nelson, M AF Turbyville, J. C. Payne, K. Gada, S. Nelson, M. TI Post-tussive Emesis as a Symptom of Asthma in Children SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 65th Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology CY MAR 13-17, 2009 CL Washington, DC SP Amer Acad Allergy, Asthma & Immunol C1 [Turbyville, J. C.; Payne, K.; Gada, S.; Nelson, M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD FEB PY 2009 VL 123 IS 2 MA 17 BP S9 EP S9 DI 10.1016/j.jaci.2008.12.044 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 410RR UT WOS:000263596300028 ER PT J AU Yin, LY Calhoun, JH Thomas, TS Wirtz, ED AF Yin, Li-Yan Calhoun, Jason H. Thomas, Theodore S. Wirtz, Eric D. TI Efficacy of telavancin in the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis: studies with a rabbit model SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY LA English DT Article ID LIPOGLYCOPEPTIDE AB Staphylococcus aureus is the most common pathogen isolated in osteomyelitis. This study evaluated the efficacies of telavancin (an investigational, rapidly bactericidal lipoglycopeptide with a multifunctional mechanism of action against Gram-positive bacteria), vancomycin and linezolid in a rabbit methicillin-resistant S. aureus (MRSA) osteomyelitis model. Localized osteomyelitis was induced in New Zealand White rabbits by percutaneous injection of 10(6) cfu of MRSA clinical isolate 168-1 into the intramedullary cavity. Two weeks post-infection, rabbits with radiographically confirmed, localized proximal tibial osteomyelitis were randomized into four groups (n = 15 per group): untreated controls; vancomycin 30 mg/kg subcutaneously every 12 h; linezolid 60 mg/kg orally every 8 h; and telavancin 30 mg/kg subcutaneously every 12 h. After 4 weeks of antibiotic treatment, animals were left untreated for 2 weeks. Rabbits were then euthanized and the tibias harvested. Bone matrix and marrow from each tibia were cultured and bacterial counts determined. For MRSA isolate 168-1, the MIC was 0.25 mg/L for telavancin, 0.5 mg/L for vancomycin and 0.5 mg/L for linezolid. Tibial cultures were positive for MRSA in 9 of 15 (60%) untreated controls, and 3 of 15 (20%) telavancin-treated, 3 of 15 (20%) vancomycin-treated and 4 of 14 (29%) linezolid-treated rabbits. Telavancin has comparable efficacy to vancomycin and linezolid in a rabbit model of MRSA osteomyelitis. C1 [Yin, Li-Yan; Calhoun, Jason H.; Thomas, Theodore S.] Univ Missouri, Dept Orthopaed Surg, Columbia, MO 65212 USA. [Wirtz, Eric D.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Calhoun, JH (reprint author), Univ Missouri, Dept Orthopaed Surg, Columbia, MO 65212 USA. EM calhounj@health.missouri.edu FU Theravance, Inc. FX This research was supported by a grant from Theravance, Inc. NR 9 TC 19 Z9 20 U1 1 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-7453 J9 J ANTIMICROB CHEMOTH JI J. Antimicrob. Chemother. PD FEB PY 2009 VL 63 IS 2 BP 357 EP 360 DI 10.1093/jac/dkn490 PG 4 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA 395LD UT WOS:000262524700024 PM 19060292 ER PT J AU Akturk, A Goldsman, N Potbhare, S Lelis, A AF Akturk, Akin Goldsman, Neil Potbhare, Siddharth Lelis, Aivars TI High field density-functional-theory based Monte Carlo: 4H-SiC impact ionization and velocity saturation SO JOURNAL OF APPLIED PHYSICS LA English DT Article DE carrier density; conduction bands; density functional theory; electronic density of states; electron-phonon interactions; impact ionisation; Monte Carlo methods; pseudopotential methods; silicon compounds; tunnelling; valence bands; wide band gap semiconductors ID 4H SILICON-CARBIDE; ELECTRON-TRANSPORT; SIC POLYTYPES; COEFFICIENTS; SIMULATION; MOSFETS AB We present 4H-SiC electron and hole Monte Carlo transport calculations that are obtained using the density functional theory (DFT) calculated conduction and valence band density-of-states (DOS) curves. The transport properties include room temperature average electron-hole velocities, energies, and impact ionization rates as functions of applied fields, as well as mobilities. This is achieved employing detailed DFT-DOS curves, which obviate the need to consider electron-hole energy dispersion details that are generally calculated using the empirical pseudopotential method. Thus the proposed method facilitates fast computations of carrier-phonon and semiclassical field-carrier interactions, and the relevant field-dependent averages. Specifically, our calculated average electron velocities peak at 1.6x10(7) cm/s for 0.2 MV/cm field bias, and the simulated electron ionization coefficients match well with experimental data in the 3-5 MV/cm range. To obtain similar averages for 4H-SiC's holes, we resolve the hole transport semiclassically in conjunction with hole-phonon couplings, but also include additional quantum tunnelinglike effects to determine experiment corroborated ionization rates. Our calculated average hole velocities saturate at roughly 1x10(7) cm/s after 0.5 MV/cm. Further, the hole ionization coefficients, which are considerably higher than the electron ionization coefficients, match with experimental data for a wide range of field values >= 2 MV/cm. C1 [Akturk, Akin; Goldsman, Neil; Potbhare, Siddharth] Univ Maryland, College Pk, MD 20742 USA. [Lelis, Aivars] USA, Res Lab, Adelphi, MD 20783 USA. RP Akturk, A (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM akturka@umd.edu NR 29 TC 8 Z9 8 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 2009 VL 105 IS 3 AR 033703 DI 10.1063/1.3074107 PG 7 WC Physics, Applied SC Physics GA 408BZ UT WOS:000263409700039 ER PT J AU Hager, CE Jones, KA Derenge, MA Zheleva, TS AF Hager, C. E. Jones, K. A. Derenge, M. A. Zheleva, T. S. TI Activation of ion implanted Si in GaN using a dual AlN annealing cap SO JOURNAL OF APPLIED PHYSICS LA English DT Article DE adhesion; aluminium compounds; annealing; diffusion; electron mobility; gallium compounds; III-V semiconductors; ion implantation; mechanical strength; MOCVD; semiconductor thin films; silicon; sputtered coatings; surface roughness; wide band gap semiconductors ID GALLIUM NITRIDE; OHMIC CONTACTS; FILMS; SILICON; STRENGTH; LAYERS AB A dual annealing cap composed of a thin, low temperature metal-organic chemical vapor deposition (MOCVD) deposited AlN adhesion layer and a thicker, sputtered AlN film for added mechanical strength enabled us to anneal Si-implanted layers for 30 min at temperatures up to 1250 degrees C. At higher temperatures the cap was destroyed by the large partial pressure of the N(2) from the GaN, which exceeds the yield strength of AlN. Electrical activations as high as 70% and electron mobilities comparable to those of in situ doped films were achieved. Compared to other methods, the surfaces are better protected using this cap because it adheres better than sputtered AlN, SiO(2), or Si(3)N(4); does not crack like MOCVD grown AlN films deposited at normal temperatures (similar to 1100 degrees C); and is stronger than thin MOCVD grown AlN films deposited at low temperatures (similar to 600 degrees C). Even though N does not escape, and in so doing, forms thermal etch pits, the surface of the annealed GaN is roughened by solid state diffusion with the surface roughness increasing with the annealing temperature. C1 [Hager, C. E.; Jones, K. A.; Derenge, M. A.; Zheleva, T. S.] USA, Res Lab, SEDD, Adelphi, MD 20783 USA. RP Hager, CE (reprint author), USA, Res Lab, SEDD, Adelphi, MD 20783 USA. EM kajones@arl.army.mil NR 31 TC 15 Z9 15 U1 1 U2 18 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 2009 VL 105 IS 3 AR 033713 DI 10.1063/1.3068317 PG 7 WC Physics, Applied SC Physics GA 408BZ UT WOS:000263409700049 ER PT J AU Tan, ZN Xu, J Zhang, CF Zhu, T Zhang, F Hedrick, B Pickering, S Wu, J Su, HP Gao, S Wang, AY Kimball, B Ruzyllo, J Dellas, NS Mohney, SE AF Tan, Zhanao Xu, Jian Zhang, Chunfeng Zhu, Ting Zhang, Fan Hedrick, Brittany Pickering, Shawn Wu, Jian Su, Huaipeng Gao, Shuai Wang, Andrew Y. Kimball, Brian Ruzyllo, Jerzy Dellas, Nicholas S. Mohney, Suzanne E. TI Colloidal nanocrystal-based light-emitting diodes fabricated on plastic toward flexible quantum dot optoelectronics SO JOURNAL OF APPLIED PHYSICS LA English DT Article DE brightness; colloids; light emitting diodes; nanostructured materials; quantum dots ID SEMICONDUCTING POLYMER; ELECTROLUMINESCENCE; PHOTODETECTORS; DEVICES; BRIGHT; ENERGY AB We report the demonstration of mechanically flexible quantum dot light emitting diodes (QD-LEDs) of all three primary colors (red, green, and blue). The QD-LEDs have been fabricated over poly(ethylene-terephthalate) substrates and exhibited high brightness, saturated colors, and pronounced flexibility with a critical bending radius of similar to 5 mm. The efficiencies of the flexible QD-LEDs are comparable with the devices fabricated on rigid substrates, suggesting the intrinsic flexibility of quantum dot-based optoelectronic devices. C1 [Tan, Zhanao; Xu, Jian; Zhang, Chunfeng; Zhu, Ting; Zhang, Fan; Hedrick, Brittany; Pickering, Shawn; Wu, Jian] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA. [Su, Huaipeng; Gao, Shuai] Tianjin Univ, Dept Chem Engn, Tianjin 300072, Peoples R China. [Wang, Andrew Y.] Ocean NanoTech LLC, Fayetteville, AR 72702 USA. [Kimball, Brian] USA, Natick Res Dev & Engn Ctr, Nanomat Sci Team, Natick, MA 01760 USA. [Ruzyllo, Jerzy] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Dellas, Nicholas S.; Mohney, Suzanne E.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. RP Tan, ZN (reprint author), Penn State Univ, Dept Engn Sci & Mech, 227 Hammond Bldg, University Pk, PA 16802 USA. EM jianxu@engr.psu.edu RI Wu, Jian/D-8134-2011; Tan, Zhan'ao/D-2691-2011; Zhang, Fan/G-5220-2012; Zhang, Chunfeng/D-4732-2013 OI Tan, Zhan'ao/0000-0003-2700-4725; Zhang, Chunfeng/0000-0001-9030-5606 FU National Science Foundation [CMMI-0729263, ECCS-0824186]; Army Research Office [49653-EL]; Ocean Nano-Tech, LLC; Army Research Office under SBIR [W911QY-06-C-0042] FX The research at Penn State University is being supported by the National Science Foundation under Grant Nos. CMMI-0729263 and ECCS-0824186 and the Army Research Office under Grant No. 49653-EL. The work at Ocean Nano-Tech, LLC. is supported by the National Science Foundation under Grant No. 0638209 and Army Research Office under SBIR Grant No. W911QY-06-C-0042. This paper is also dedicated to Professor Yongfang Li on the occasion of his 60th birthday. NR 23 TC 23 Z9 24 U1 0 U2 20 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 2009 VL 105 IS 3 AR 034312 DI 10.1063/1.3074335 PG 5 WC Physics, Applied SC Physics GA 408BZ UT WOS:000263409700101 ER PT J AU Popovic, D King, C Guerrero, M Levendowski, DJ Henninger, D Westbrook, PR AF Popovic, Djordje King, Christopher Guerrero, Melanie Levendowski, Daniel J. Henninger, Delmer Westbrook, Philip R. TI VALIDATION OF FOREHEAD VENOUS PRESSURE AS A MEASURE OF RESPIRATORY EFFORT FOR THE DIAGNOSIS OF SLEEP APNEA SO JOURNAL OF CLINICAL MONITORING AND COMPUTING LA English DT Article DE respiratory effort; sleep disordered breathing; central sleep apnea; OSA; effort bands; venous pressure; photoplethysmography AB Objectives. The aim of the study was to validate the measurement of Forehead Venous Pressure derived from a single site on the forehead as an alternative to esophageal manometry and respiratory effort bands in the differential diagnosis of sleep apnea. Methods. Fourteen subjects underwent a laboratory polysomnography concurrently with ARES Unicorder at Walter Reed Army Medical Center. Two-hundred respiratory events were selected by a scorer boarded in sleep medicine and classified into six event categories used in the differential diagnosis of sleep disordered breathing. Four sets of events were prepared, each containing airflow and one of four measures of respiratory effort (i.e., esophageal manometer, chest and abdomen bands, and forehead venous pressure). A second board-certified scorer scored each set of events twice while blinded to the type of the effort signal. Results. The inter-rater Kappa scores across all event types indicated all four effort signals provided moderate agreement (kappa = 0.43-0.47). When comparing the intra-rater Kappa scores, the chest belt was superior (kappa = 0.88) to the esophageal manometry, FVP and abdomen belt (kappa = 0.78-0.82). The Kappa scores for the intra-rater comparison with the esophageal serving as the gold standard, FVP abdomen and chest all showed near perfect agreement (kappa = 0.81-0.86). The esophageal manometer and FVP provided slightly better inter-rater agreement in the detection of both obstructive hypopneas and apneas as compared to the chest and abdomen belts. There was a 20-30% drop in inter-rater reliability in the detection of flow-limitation and ventilation-change events compared to obstructive events, and all effort signals showed poor inter-rater agreement for central and mixed events. Conclusions. The results of the study suggest that the FVP can serve as an alternative to respiratory bands in the differential diagnosis of sleep disordered breathing, and in the recognition of patients appropriate for bilevel continuous positive airway pressure devices. C1 [Levendowski, Daniel J.; Westbrook, Philip R.] Adv Brain Monitoring Inc, Carlsbad, CA 92008 USA. [Popovic, Djordje] Univ So Calif, Los Angeles, CA USA. [King, Christopher; Guerrero, Melanie] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Henninger, Delmer] Complete Sleep Solut Inc, Murrieta, CA USA. RP Levendowski, DJ (reprint author), Adv Brain Monitoring Inc, 2237 Faraday Ave,Suite 100, Carlsbad, CA 92008 USA. EM Dan@b-alert.com FU NIH [5R44HL068463-05, 1R43HL088781-01, R44DE016772] FX Dr. Popovic was a consultant to and now is an employee of Advanced Brain Monitoring, Inc. Mr. Levendowski and Dr. Westbrook are employees and shareholders in Advanced Brain Monitoring, Inc. This study was partially funded by NIH Grants 5R44HL068463-05, 1R43HL088781-01, R44DE016772. The authors wish to thank Teotimo Andrada of Walter Reed Army Medical Center for assistance in acquiring the PSG and ARES data, and Daniela Scarfeo and Timothy Zavora of Advanced Brain Monitoring for assistance in processing and reviewing the ARES data. NR 29 TC 6 Z9 6 U1 0 U2 4 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1387-1307 J9 J CLIN MONIT COMPUT JI J. Clin. Monitor. Comp. PD FEB PY 2009 VL 23 IS 1 BP 1 EP 10 DI 10.1007/s10877-008-9154-8 PG 10 WC Anesthesiology SC Anesthesiology GA V20OZ UT WOS:000208150600001 PM 19116764 ER PT J AU Liu, XY Wazne, M Christodoulatos, C Jasinkiewicz, KL AF Liu, Xuyang Wazne, Mahmoud Christodoulatos, Christos Jasinkiewicz, Kristin L. TI Aggregation and deposition behavior of boron nanoparticles in porous media SO JOURNAL OF COLLOID AND INTERFACE SCIENCE LA English DT Article DE Nanoparticles; Boron; Aggregation; Deposition; Fate and transport; DLVO; Critical coagulation concentration; Attachment efficiency; Primary energy minima; Secondary energy minima ID NATURAL ORGANIC-MATTER; UNFAVORABLE CHEMICAL CONDITIONS; FULLERENE C-60 NANOPARTICLES; PARTICLE ADHESION; ELECTROLYTE-SOLUTIONS; COLLOIDAL STABILITY; LATEX-PARTICLES; BED FILTRATION; MODEL SYSTEMS; KINETICS AB New kinds of solid fuels and propellants comprised of nanomaterials are making their way into civilian and military applications yet the impact of their release on the environment remains largely unknown. One such material is nano boron, a promising solid fuel and propellant. The fate and transport of nano boron under various aquatic systems was investigated in aggregation and deposition experiments. Column experiments were performed to examine the effects of electrolyte concentration and flow velocity on the transport of boron nanoparticles under saturated conditions, whereas aggregation tests were conducted to assess the effects of electrolytes on the aggregation of the boron nanoparticles. Aggregation tests indicated the presence of different reaction-controlled and diffusion-controlled regimes and yielded critical coagulation concentrations (CCC) of 200 mM, 0.7 mM and 1.5 mM for NaCl, CaCl(2), and MgCl(2), respectively. Aggregation and deposition experimental data corresponded with the classic Derjaguin-Landau-Verwey-Overbeek (DLVO) model and the constant attachment efficiency filtration model, respectively. Theoretical calculations indicated that both the primary and secondary energy minima play important roles in the deposition of nano boron in sand columns. (C) 2008 Elsevier Inc. All rights reserved. C1 [Liu, Xuyang; Wazne, Mahmoud; Christodoulatos, Christos] Stevens Inst Technol, Ctr Environm Syst, Keck Geotech Geoenvironm Lab, Hoboken, NJ 07030 USA. [Jasinkiewicz, Kristin L.] USA, Demil & Environm Technol Div, Picatinny Arsenal, NJ 07806 USA. RP Wazne, M (reprint author), Stevens Inst Technol, Ctr Environm Syst, Keck Geotech Geoenvironm Lab, Hoboken, NJ 07030 USA. EM mwazne@stevens.edu RI Liu, Xuyang/F-3373-2011 FU RDECOM/ARDEC [W15QKN-05-D-011] FX This study Was Supported by RDECOM/ARDEC, Picatinny Arsenal under Contract #W15QKN-05-D-011. NR 49 TC 44 Z9 45 U1 1 U2 19 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9797 J9 J COLLOID INTERF SCI JI J. Colloid Interface Sci. PD FEB 1 PY 2009 VL 330 IS 1 BP 90 EP 96 DI 10.1016/j.jcis.2008.10.028 PG 7 WC Chemistry, Physical SC Chemistry GA 391JN UT WOS:000262229700013 PM 18977491 ER PT J AU Distefano, MJ O'Brien, WJ AF Distefano, Marc J. O'Brien, William J. TI Comparative Analysis of Infrastructure Assessment Methodologies at the Small Unit Level SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT-ASCE LA English DT Article AB This paper presents a comparative analysis of three different infrastructure assessment tools currently used by the U.S. Army's combat engineer small units (squad, platoon, company). The infrastructure assessment tools included one pen and paper checklist and two software-based tools based on specialized handheld hardware for data collection in combat conditions. Evaluation was conducted using macroergonomic and applied cognitive task analysis methods with soldiers of varying levels of infrastructure assessment expertise. Each assessment method was evaluated based on performance (time, errors, and accuracy) and usability (ergonomic and cognitive challenges). We found that soldiers documented more accurate data using handheld digital devices instead of pen-and-paper assessment forms, but there was little difference in time between the methods. Contrary to initial expectation, we also found that most soldiers prefer a slightly more difficult to use handheld assessment device with customized checklists rather than an easier to use, less restrictive device. Critiques developed by this research can be used to improve engineering and construction organizations as well as add to our design guidelines for portable infrastructure assessment tools and methods. C1 [Distefano, Marc J.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [O'Brien, William J.] Univ Texas Austin, Construct Engn & Project Management Program, Dept Civil Architectural & Environm Engn, Austin, TX 78712 USA. RP Distefano, MJ (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. FU CERL; EI2RC FX The writers thank the officers and soldiers of the 1st BCT, 1st CD, the 1-395 EN BN, the officers and cadets of West Point's Systems Department, CERL for their support on HAMMER, and EI2RC for their support with GATER. NR 10 TC 2 Z9 2 U1 0 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9364 J9 J CONSTR ENG M ASCE JI J. Constr. Eng. Manage.-ASCE PD FEB PY 2009 VL 135 IS 2 BP 96 EP 107 DI 10.1061/(ASCE)0733-9364(2009)135:2(96) PG 12 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA 395LV UT WOS:000262526500003 ER PT J AU Quinn, MJ McKernan, M Lavoie, ET Ottinger, MA AF Quinn, Michael James, Jr. McKernan, Moira Lavoie, Emma T. Ottinger, Mary Ann TI Effects of Estradiol on the Development of the Bursa of Fabricius in Japanese Quail SO JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL GENETICS AND PHYSIOLOGY LA English DT Article ID IMMUNE; BURSECTOMY; ESTROGEN AB Effects of androgens on the development of the bursa of Fabricius are better understood than those of estradiol, despite the known sensitivity of the bursa to estradiol early in embryogenesis. The goal of this study was to determine the effects of one-time yolk injections of estradiol at day 4 of incubation on the development of the bursa and spleen as indices of treatment effects on the immune system. Follicle size and numbers in hatchling bursas were significantly reduced at 50 and 500 mu g/egg, respectively. Additionally, distorted plicae and thicker epithelial layers surrounding the plicae were observed in day-old chicks at the same treatment levels. Adult bursas from birds embryonically exposed to estrogen were significantly larger than controls, suggesting an inhibition of natural bursal regression. Although estradiol altered the development of the bursa, the spleen appeared to be unaffected. The observed effects of estradiol on the development of the bursa indicate that this lymphoid organ may be a target for developmental disruption by estrogenic endocrine disrupting chemicals, though long-term consequences of embryonic exposure on immune function remain unknown. J. Exp. Zool. 311A:91-95, 2009. (c) 2008 Wiley-Liss, Inc. C1 [Quinn, Michael James, Jr.] USA, Ctr Hlth Promot & Prevent Med, Edgewood Area, Aberdeen Proving Ground, MD 21010 USA. [McKernan, Moira] Univ Maryland, Marine Estuarine & Environm Sci Dept, College Pk, MD 20742 USA. [Lavoie, Emma T.; Ottinger, Mary Ann] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA. RP Quinn, MJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Edgewood Area, Bldg E-2100, Aberdeen Proving Ground, MD 21010 USA. EM michael.james.quinn@us.army.mil FU EPA [R826134010]; Battelle contract FX Grant sponsor: EPA; Grant number: R826134010; Grant sponsor: Battelle contract. NR 15 TC 6 Z9 7 U1 0 U2 9 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1932-5223 J9 J EXP ZOOL PART A JI J. Exp. Zool. Part A PD FEB 1 PY 2009 VL 311A IS 2 BP 91 EP 95 DI 10.1002/jez.504 PG 5 WC Zoology SC Zoology GA 420UY UT WOS:000264315900003 PM 18925651 ER PT J AU Baird, DC Usatine, RP AF Baird, Drew C. Usatine, Richard P. TI Bilateral lea edema and difficulty swallowing SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material ID ACHALASIA; DIAGNOSIS C1 [Baird, Drew C.] DD Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA 30905 USA. [Usatine, Richard P.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA. RP Baird, DC (reprint author), DD Eisenhower Army Med Ctr, Dept Family & Community Med, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM drew.baird@us.army.mil NR 6 TC 1 Z9 1 U1 0 U2 0 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD FEB PY 2009 VL 58 IS 2 BP 89 EP 92 PG 4 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 408FB UT WOS:000263419800008 PM 19203493 ER PT J AU Vietri, NJ Purcell, BK Tobery, SA Rasmussen, SL Leffel, EK Twenhafel, NA Ivins, BE Kellogg, MD Webster, WM Wright, ME Friedlander, AM AF Vietri, Nicholas J. Purcell, Bret K. Tobery, Steven A. Rasmussen, Suzanne L. Leffel, Elizabeth K. Twenhafel, Nancy A. Ivins, Bruce E. Kellogg, Mark D. Webster, Wendy M. Wright, Mary E. Friedlander, Arthur M. TI A Short Course of Antibiotic Treatment Is Effective in Preventing Death from Experimental Inhalational Anthrax after Discontinuing Antibiotics SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PROTECTIVE ANTIGEN; BACILLUS-ANTHRACIS; IMMUNOGLOBULIN-G; PROPHYLAXIS; PATHOGENESIS; ANTIBODIES; PATHOLOGY; OUTBREAK; VACCINE; SPORES AB Background. Postexposure prophylaxis of inhalational anthrax requires prolonged antibiotic therapy or antibiotics and vaccination. The duration of treatment for established anthrax is controversial, because retained spores may germinate and cause disease after antibiotics are discontinued. Using rhesus macaques, we determined whether a short course of antibiotic treatment, as opposed to prophylaxis, could effectively treat inhalational anthrax and prevent disease caused by the germination of spores after discontinuation of antibiotics. Methods. Two groups of 10 rhesus macaques were exposed to an aerosol dose of Bacillus anthracis spores. Animals in group 1 received ciprofloxacin prophylaxis beginning 1-2 h after exposure. Those in group 2 began receiving ciprofloxacin after becoming bacteremic, and treatment was continued for 10 days. When each group 2 animal completed 10 days of therapy, the prophylactic antibiotic was discontinued in the paired group 1 animal. Results. In group 1 (prophylaxis), no deaths occurred during antibiotic treatment, but only 2 (20%) of 10 animals survived after antibiotics were discontinued. In contrast, in group 2 (treatment), 3 deaths occurred during antibiotic treatment, but all 7 animals (100%) alive after 10 days of therapy survived when antibiotics were discontinued. Conclusions. In the treatment of inhalational anthrax, the prolonged course of antibiotics required to achieve prophylaxis may not be necessary to prevent anthrax that results from the germination of retained spores after the discontinuation of antibiotics. C1 [Vietri, Nicholas J.; Purcell, Bret K.; Tobery, Steven A.; Rasmussen, Suzanne L.; Ivins, Bruce E.; Webster, Wendy M.] USA, Med Res Inst Infect Dis, Div Bacteriol, Frederick, MD 21702 USA. [Twenhafel, Nancy A.] USA, Med Res Inst Infect Dis, Div Pathol, Frederick, MD 21702 USA. [Kellogg, Mark D.] USA, Med Res Inst Infect Dis, Div Diagnost Syst, Frederick, MD 21702 USA. [Leffel, Elizabeth K.] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Frederick, MD 21702 USA. [Wright, Mary E.] NIAID, Bethesda, MD 20892 USA. RP Vietri, NJ (reprint author), USA, Med Res Inst Infect Dis, Div Bacteriol, 1425 Porter St, Frederick, MD 21702 USA. EM nicholas.vietri@amedd.army.mil; arthur.friedlander@amedd.army.mil OI Kellogg, Mark/0000-0003-1868-2153 NR 30 TC 16 Z9 16 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 1 PY 2009 VL 199 IS 3 BP 336 EP 341 DI 10.1086/596063 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 392UB UT WOS:000262326600007 PM 19099484 ER PT J AU Glackin, J Ecker, JG Kupferschmid, M AF Glackin, J. Ecker, J. G. Kupferschmid, M. TI Solving Bilevel Linear Programs Using Multiple Objective Linear Programming SO JOURNAL OF OPTIMIZATION THEORY AND APPLICATIONS LA English DT Article DE Bilevel linear programming; Multiple objective linear programming; Efficient set; Rational reaction set; Simplex algorithm pivot ID EFFICIENT SET; MATHEMATICAL PROGRAMS; EXTREME-POINT; ALGORITHM; OPTIMIZATION; CONSTRAINTS; SEARCH AB We present an algorithm for solving bilevel linear programs that uses simplex pivots on an expanded tableau. The algorithm uses the relationship between multiple objective linear programs and bilevel linear programs along with results for minimizing a linear objective over the efficient set for a multiple objective problem. Results in multiple objective programming needed are presented. We report computational experience demonstrating that this approach is more effective than a standard branch-and-bound algorithm when the number of leader variables is small. C1 [Glackin, J.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Ecker, J. G.] Rensselaer Polytech Inst, Dept Math Sci, Troy, NY 12180 USA. [Kupferschmid, M.] Rensselaer Polytech Inst, Acad & Res Comp, Troy, NY 12180 USA. RP Glackin, J (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM james.glackin@us.army.mil; eckerj@rpi.edu; mikek@rpi.edu NR 30 TC 7 Z9 8 U1 3 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-3239 J9 J OPTIMIZ THEORY APP JI J. Optim. Theory Appl. PD FEB PY 2009 VL 140 IS 2 BP 197 EP 212 DI 10.1007/s10957-008-9467-2 PG 16 WC Operations Research & Management Science; Mathematics, Applied SC Operations Research & Management Science; Mathematics GA 402AZ UT WOS:000262987900001 ER PT J AU Hannah, ST Woolfolk, RL Lord, RG AF Hannah, Sean T. Woolfolk, Robert L. Lord, Robert G. TI Leader self-structure: a framework for positive leadership SO JOURNAL OF ORGANIZATIONAL BEHAVIOR LA English DT Review ID SPREADING ACTIVATION; RELEVANT INFORMATION; JOB-SATISFACTION; MENTAL CONTROL; MEDIATING ROLE; IDENTITY; COMPLEXITY; CHARISMA; EFFICACY; ESTEEM AB We expand the conceptualization of positive leadership and hypothesize that leaders' ability to influence followers across varied complex situations will be enhanced through the development of a rich and multifaceted self-construct. Utilizing self-complexity theory and other aspects of research on self-representation, we show how the structure and structural dynamics of leaders' self-constructs are linked to their varied role demands by calling forth cognitions, affects, goals and values, expectancies, and self-regulatory plans that enhance performance. Through this process, a leader is able to bring the "right stuff" (the appropriate ensemble of attributes) to bear on and succeed in the multiple challenges of leadership. We suggest future research to develop dimensional typologies related to leadership-relevant aspects of the self and also to link individual positive self-complexity to more aggregate positive organizational processes. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 [Hannah, Sean T.] US Mil Acad, Dept Behav Sci & Leadership Leadership & Manageme, West Point, NY 10996 USA. [Woolfolk, Robert L.] Rutgers State Univ, Dept Psychol, Piscataway, NJ USA. [Woolfolk, Robert L.] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA. [Lord, Robert G.] Univ Akron, Dept Psychol, Akron, OH 44325 USA. RP Hannah, ST (reprint author), US Mil Acad, Dept Behav Sci & Leadership Leadership & Manageme, West Point, NY 10996 USA. EM Sean.Hinnah@usma.edu RI Woolfolk, Robert/N-7265-2016 NR 102 TC 38 Z9 38 U1 12 U2 48 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0894-3796 J9 J ORGAN BEHAV JI J. Organ. Behav. PD FEB PY 2009 VL 30 IS 2 BP 269 EP 290 DI 10.1002/job.586 PG 22 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA 415HC UT WOS:000263923900008 ER PT J AU Fawcett, WP Aracava, Y Adler, M Pereira, EFR Albuquerque, EX AF Fawcett, William P. Aracava, Yasco Adler, Michael Pereira, Edna F. R. Albuquerque, Edson X. TI Acute Toxicity of Organophosphorus Compounds in Guinea Pigs Is Sex- and Age-Dependent and Cannot Be Solely Accounted for by Acetylcholinesterase Inhibition SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID SOMAN TOXICITY; HIGH-AFFINITY; NERVE AGENT; BRAIN; CHOLINESTERASE; RAT; EXPOSURE; BLOOD; NEUROTOXICITY; TESTOSTERONE AB This study was designed to test the hypothesis that the acute toxicity of the nerve agents S-[2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate (VX), O-pinacolyl methylphosphonofluoridate (soman), and O-isopropyl methylphosphonofluoridate ( sarin) in guinea pigs is age- and sex-dependent and cannot be fully accounted for by the irreversible inhibition of acetylcholinesterase (AChE). The subcutaneous doses of nerve agents needed to decrease 24-h survival of guinea pigs by 50% (LD(50) values) were estimated by probit analysis. In all animal groups, the rank order of LD(50) values was sarin > soman > VX. The LD(50) value of soman was not influenced by sex or age of the animals. In contrast, the LD(50) values of VX and sarin were lower in adult male than in age- matched female or younger guinea pigs. A colorimetric assay was used to determine the concentrations of nerve agents that inhibit in vitro 50% of AChE activity (IC(50) values) in guinea pig brain extracts, plasma, red blood cells, and whole blood. A positive correlation between LD(50) values and IC(50) values for AChE inhibition would support the hypothesis that AChE inhibition is a major determinant of the acute toxicity of the nerve agents. However, such a positive correlation was found only between LD(50) values and IC(50) values for AChE inhibition in brain extracts from neonatal and prepubertal guinea pigs. These results demonstrate for the first time that the lethal potencies of some nerve agents in guinea pigs are age- and sex-dependent. They also support the contention that mechanisms other than AChE inhibition contribute to the lethality of nerve agents. C1 [Fawcett, William P.; Aracava, Yasco; Pereira, Edna F. R.; Albuquerque, Edson X.] Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA. [Adler, Michael] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Albuquerque, EX (reprint author), Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, 655 W Baltimore St, Baltimore, MD 21201 USA. EM ealbuque@umaryland.edu FU NINDS NIH HHS [U01-NS059344, U01 NS059344] NR 40 TC 13 Z9 13 U1 0 U2 7 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD FEB PY 2009 VL 328 IS 2 BP 516 EP 524 DI 10.1124/jpet.108.146639 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 396WZ UT WOS:000262623600017 PM 18984651 ER PT J AU Sloop, JC AF Sloop, Joseph C. TI Quinoline formation via a modified Combes reaction: examination of kinetics, substituent effects, and mechanistic pathways SO JOURNAL OF PHYSICAL ORGANIC CHEMISTRY LA English DT Article DE Hammett correlation; steric effects; substituent effects; kinetics; Combes quinoline synthesis; trifluoromethyl-1,3-diketones ID TAUTOMERISM; DERIVATIVES; CYCLIZATION; CONSTANTS; SERIES; ETHYL; ACID; ENOL AB A comprehensive product regioselectivity and kinetics study of the modified Combes quinoline synthesis shown below has been undertaken: [GRAPHICS] This is the first reported investigation of the Combes condensation employing 19F NMR spectroscopy to monitor intermediate consumption and product formation rates. The reaction was found to be first order in both the diketone and aniline. Product regioselectivity and reaction rates were found to be influenced by substituents on the diketones and anilines with rates varying as much as five fold. The consumption rate of key imine and enamine intermediates mirrored quinoline formation rates, in accord with rate determining annulation. A rho of -0.32 was determined for this cyclization. While the sign of the reaction constant is consistent with rate limiting electrophilic aromatic substitution (EAS), the magnitude is likely a composite value, resulting from opposing substituent effects in the nucleophilic addition and EAS steps. Mechanistic details and reaction pathways supporting these findings are proposed. Copyright (c) 2008 John Wiley & Sons, Ltd. C1 US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Sloop, JC (reprint author), US Mil Acad, Dept Chem & Life Sci, 646 Swift Rd, West Point, NY 10996 USA. EM joseph.sloop@usma.edu OI Sloop, Joseph/0000-0001-7639-0234 FU USMA FX The author is indebted to Dr Gary Washington for the useful kinetics discussions. The author thanks the USMA Faculty Research Fund for providing financial support for this work. NR 43 TC 13 Z9 14 U1 3 U2 18 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0894-3230 J9 J PHYS ORG CHEM JI J. Phys. Org. Chem. PD FEB PY 2009 VL 22 IS 2 BP 110 EP 117 DI 10.1002/poc.1433 PG 8 WC Chemistry, Organic; Chemistry, Physical SC Chemistry GA 397XD UT WOS:000262694800004 ER PT J AU Zhang, SS Foster, D Wolfenstine, J Read, J AF Zhang, Sheng S. Foster, Donald Wolfenstine, Jeff Read, Jeffrey TI Electrochemical characteristic and discharge mechanism of a primary Li/CFx cell SO JOURNAL OF POWER SOURCES LA English DT Article DE Carbon monofluoride; Graphite intercalation compound; Discharge; Impedance; Lithium battery ID SOLID-ELECTROLYTE INTERFACE; PRIMARY LITHIUM BATTERIES; GRAPHITE OXIDE AB dc-polarization and ac-impedance techniques were used to analyze the discharge characteristic of a primary Li/CFx cell. In most cases, impedance spectrum of a Li/CFx cell shows a suppressed semicircle followed by a sloping straight line. The semicircle is shown to present a cell reaction resistance (R-cr), which reflects an ohmic resistance (mainly, ionic conductivity of the discharge product shell) and a charge-transfer process. It is shown that the overall resistance of a Li/CFx cell is dominated by the CFx cathode, whose resistance is further dominated by the R-cr that is found to be extremely sensitive to the temperature. Therefore, the low temperature performance and rate capability of a Li/CFx cell are mainly determined by the CFx cathode. In addition, based on the discharge curve and open circuit voltage (OCV) recovery of a Li/CFx cell, we proposed a "core-shell" model consisting of a shrinking "CFx core" and a growing "product shell" for the discharge process of CFx, cathode. The "product shell" plays an important role in the discharge performance of Li/CFx cells. Published by Elsevier B.V. C1 [Zhang, Sheng S.; Foster, Donald; Wolfenstine, Jeff; Read, Jeffrey] USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 20 TC 31 Z9 33 U1 7 U2 69 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD FEB 1 PY 2009 VL 187 IS 1 SI SI BP 233 EP 237 DI 10.1016/j.jpowsour.2008.10.076 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 406PB UT WOS:000263306300030 ER PT J AU Karl, JP Lieberman, HR Cable, SJ Williams, KW Glickman, EL Young, AJ McClung, JP AF Karl, J. Philip Lieberman, Harris R. Cable, Sonya J. Williams, Kelly W. Glickman, Ellen L. Young, Andrew J. McClung, James P. TI Poor Iron Status Is Not Associated with Overweight or Overfat in Non-Obese Pre-Menopausal Women SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Article; Proceedings Paper CT Annual Scientific Meeting of the Obesity-Society CY OCT 03-07, 2008 CL Phoenix, AZ SP Obes Soc DE iron; iron deficiency; obesity; body fat ID SOLUBLE TRANSFERRIN RECEPTOR; DEFICIENCY; HEPCIDIN; OBESITY; ADOLESCENTS; ABSORPTION; CHILDREN; HYPOFERREMIA; INFLAMMATION; PREVALENCE AB Background: Associations between obesity and poor iron status have been described in children and adults. Proposed mechanisms for this association implicate a physiologic etiology, suggesting body fat accretion may progressively degrade iron status. However, the relationship between iron status and body composition in non-obese adults remains unclear. Objective: In this study we examined the relationship between body composition, inflammation, and iron status in healthy, non-obese, pre-menopausal females. Methods: Iron status was assessed using red cell distribution width, transferrin saturation, serum ferritin, and soluble transferrin receptor (sTfR). Tumor-necrosis factor-a provided a marker of inflammation, and body fat percentage (BF) was calculated from mean skinfold thickness measurements at 3 sites. Results: In this cohort (n = 207), the prevalence of iron deficiency was similar (p > 0.05) between normal and overweight (BMI 25.0-30.0 kg/m(2)), and normal and overfat (BF >= 30.0%) volunteers. There were no differences in individual iron status indicators, including sTfR, between overweight or overfat volunteers as compared to normal weight and normal fat peers. Logistic regression analyses indicated that overfat volunteers had a lower (p < 0.05) risk of iron deficiency, whereas overweight individuals demonstrated no change in relative risk as compared to peers. Conclusion: These findings suggest that, in non-obese adults, decrements in iron status are not associated with increasing adiposity. C1 [Karl, J. Philip; Lieberman, Harris R.; Glickman, Ellen L.; Young, Andrew J.; McClung, James P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. RP McClung, JP (reprint author), 42 Kansas St, Natick, MA 01760 USA. EM James.McClung@amedd.army.mil RI McClung, James/A-1989-2009; OI Karl, J. Philip/0000-0002-5871-2241 NR 32 TC 12 Z9 13 U1 1 U2 3 PU AMER COLLEGE NUTRITION PI CLEARWATER PA 300 SOUTH DUNCAN AVENUE, STE 225, CLEARWATER, FL 33755 USA SN 0731-5724 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD FEB PY 2009 VL 28 IS 1 BP 37 EP 42 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 471FJ UT WOS:000268041000006 PM 19571158 ER PT J AU Gates, JD Carmichael, MG Benavides, LC Holmes, JP Hueman, MT Woll, MM Ioannides, CG Robson, CH McLeod, DG Ponniah, S Peoples, GE AF Gates, Jeremy D. Carmichael, Mark G. Benavides, Linda C. Holmes, Jarrod P. Hueman, Matthew T. Woll, Michael M. Ioannides, Constantine G. Robson, Craig H. McLeod, David G. Ponniah, Sathibalan Peoples, George E. TI Longterm Followup Assessment of a HER2/neu Peptide (E75) Vaccine for Prevention of Recurrence in High-Risk Prostate Cancer Patients SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID FOLATE-BINDING-PROTEIN; IN-SITU HYBRIDIZATION; PHASE-II TRIAL; PROGNOSTIC-SIGNIFICANCE; RADICAL PROSTATECTOMY; ANTIGEN RECURRENCE; METASTATIC BREAST; OVARIAN-CANCER; HER-2/NEU; IDENTIFICATION AB BACKGROUND: E75 is an immunogenic peptide from the HER2/neu protein that is expressed in prostate cancer. High-risk prostate cancer (HRPC) patients demonstrating varying levels of HER2/neu expression were vaccinated with E75 peptide Plus granulocyte-macrophage colony-stimulating factor to prevent postprostatectomy PSA and clinical recurrences. STUDY DESIGN: Forty evaluable HRPC patients were prospectively identified using the validated Center for Prostate Disease Research/CaPSURE high-risk equation and enrolled. HLA-A2(+) patients (n = 21) were vaccinated, and HLA-A2(-) patients (n = 19) were followed as clinical controls. All patients were assessed for clinicopathologic factors, biochemical recurrence (consecutive PSA value >= 0.2 ng/mL), clinical recurrence, and survival. RESULTS: Comparing the vaccinated and control groups, there were no statistical differences in clinicopathologic prognostic factors. At a median followup of 58.2 months (range 18.8 to 62.7 months), PSA recurrence rates were not different between vaccinated (29%) and control (26%) groups. Median time to recurrence from operation was 14.0 months (range 5.7 to 53.4 months) versus 8.5 months (range 4.7 to 34.1 months) (p = 0.7), respectively. Three vaccinated patients had PSA recurrences during the vaccine series. If these patients were excluded, median time to recurrence for the vaccinated group extends to 42.7 months (range 20.4 to 53.4 months) (p = 0.4). Study-wide, only one clinical recurrence and death occurred in a vaccinated patient that was early in the vaccine series. Subset analysis comparing vaccinated recurrent patients with control recurrences noted some statistical trends. CONCLUSIONS: The HER2/neu (E75) vaccine can prevent or delay recurrences in HRPC patients if completed before PSA recurrence. A larger randomized phase II trial in HLA-A2(+) patients will be required to confirm these findings. (J Am Coll Surg 2009;208:193-201. (C) 2009 by the American College of Surgeons) C1 [Gates, Jeremy D.; Benavides, Linda C.; Peoples, George E.] Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, Ft Sam Houston, TX 78234 USA. [Carmichael, Mark G.; Hueman, Matthew T.; Woll, Michael M.; Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD 20814 USA. [Carmichael, Mark G.] Walter Reed Army Med Ctr, Div Med, Hematol & Med Oncol Serv, Washington, DC 20307 USA. [Holmes, Jarrod P.] USN, San Diego Med Ctr, Dept Hematol & Med Oncol, San Diego, CA 92152 USA. [Ioannides, Constantine G.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Robson, Craig H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA. [McLeod, David G.] Walter Reed Army Med Ctr, Dept Urol, Ctr Prostate Dis Res, Washington, DC 20307 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@amedd.army.mil FU Center for Prostate Disease Research; Henry M Jackson Foundation for the Advancement of Military Medicine FX Supported by grants from the Center for Prostate Disease Research, a Congressionally funded program of the Henry M Jackson Foundation for the Advancement of Military Medicine. NR 38 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD FEB PY 2009 VL 208 IS 2 BP 193 EP 201 DI 10.1016/j.jamcollsurg.2008.10.018 PG 9 WC Surgery SC Surgery GA 407TP UT WOS:000263387500004 PM 19228530 ER PT J AU Pak, JH Kou, ZQ Kwon, HJ Lee, JJ AF Pak, Jang Hyuk Kou, Zhiqing Kwon, Hyuk Jae Lee, Jiin-Jen TI PREDICTING DEBRIS YIELD FROM BURNED WATERSHEDS: COMPARISON OF STATISTICAL AND ARTIFICIAL NEURAL NETWORK MODELS SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE debris; fire; sediment; mountain; watersheds; statistical and artificial neural networks ID EVENTS; FIRE AB Alluvial fans in southern California are continuously being developed for residential, industrial, commercial, and agricultural purposes. Development and alteration of alluvial fans often require consideration of mud and debris flows from burned mountain watersheds. Accurate prediction of sediment (hyper-concentrated sediment or debris) yield is essential for the design, operation, and maintenance of debris basins to safeguard properly the general population. This paper presents results based on a statistical model and Artificial Neural Network (ANN) models. The models predict sediment yield caused by storms following wildfire events in burned mountainous watersheds. Both sediment yield prediction models have been developed for use in relatively small watersheds (50-800 ha) in the greater Los Angeles area. The statistical model was developed using multiple regression analysis on sediment yield data collected from 1938 to 1983. Following the multiple regression analysis, a method for multi-sequence sediment yield prediction under burned watershed conditions was developed. The statistical model was then calibrated based on 17 years of sediment yield, fire, and precipitation data collected between 1984 and 2000. The present study also evaluated ANN models created to predict the sediment yields. The training of the ANN models utilized single storm event data generated for the 17-year period between 1984 and 2000 as the training input data. Training patterns and neural network architectures were varied to further study the ANN performance. Results from these models were compared with the available field data obtained from several debris basins within Los Angeles County. Both predictive models were then applied for hind-casting the sediment prediction of several post 2000 events. Both the statistical and ANN models yield remarkably consistent results when compared with the measured field data. The results show that these models are very useful tools for predicting sediment yield sequences. The results can be used for scheduling cleanout operation of debris basins. It can be of great help in the planning of emergency response for burned areas to minimize the damage to properties and lives. C1 [Pak, Jang Hyuk] US Army Corps Engineers, Inst Water Resources, Hydraul Engn Ctr, Davis, CA 95616 USA. [Pak, Jang Hyuk; Kou, Zhiqing; Lee, Jiin-Jen] Univ So Calif, Dept Civil & Environm Engn, Los Angeles, CA 90089 USA. [Kwon, Hyuk Jae] Kangwon Natl Univ, Dept Civil Engn, Chunchon 200701, South Korea. RP Pak, JH (reprint author), US Army Corps Engineers, Inst Water Resources, Hydraul Engn Ctr, 609 2nd St, Davis, CA 95616 USA. EM hyukjae68@hotmail.com NR 29 TC 3 Z9 3 U1 1 U2 4 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1093-474X J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD FEB PY 2009 VL 45 IS 1 BP 210 EP 223 DI 10.1111/j.1752-1688.2008.00272.x PG 14 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 402QE UT WOS:000263027400018 ER PT J AU Jackson, WM Aragon, AB Djouad, F Song, Y Koehler, SM Nesti, LJ Tuan, RS AF Jackson, W. M. Aragon, A. B. Djouad, F. Song, Y. Koehler, S. M. Nesti, L. J. Tuan, R. S. TI Mesenchymal progenitor cells derived from traumatized human muscle SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE LA English DT Article DE mesenchymal stem cells; multipotent progenitor cells; muscle stem cells; heterotopic ossification; regenerative medicine; orthopaedic trauma ID HUMAN BONE-MARROW; HUMAN TRABECULAR BONE; HUMAN SYNOVIAL-MEMBRANE; ADULT STEM-CELLS; STROMAL CELLS; HETEROTOPIC OSSIFICATION; IN-VITRO; UMBILICAL-CORD; DIFFERENTIATION; TISSUE AB Mesenchymal stem cells (MSCs) derived from adult tissues are an important candidate cell type for cell-based tissue engineering and regenerative medicine. Currently, clinical applications for MSCs require additional surgical procedures to harvest the autologous MSCs (i.e. from bone marrow) or commercial allogeneic alternatives. We have recently identified a population of mesenchymal progenitor cells (MPCs) in traumatized muscle tissue that has been surgically debrided from traumatic orthopaedic extremity wounds. The purpose of this study was to evaluate whether MPCs derived from traumatized muscle may provide a clinical alternative to bone-marrow MSCs, by comparing their morphology, proliferation capacity, cell surface epitope profile and differentiation capacity. After digesting the muscle tissue with collagenase, the MPCs were enriched by a direct plating technique. The morphology and proliferation rate of the muscle-derived MPCs was similar to bone-marrow derived MSCs. Both populations expressed cell surface markers characteristic for MSCs (CD 73, CD 90 and CD105), and did not express markers typically absent on MSCs (CD14, CD34 and CD45). After 21 days in specific differentiation media, the histological staining and gene expression of the MPCs and MSCs was characteristic for differentiation into osteoblasts, chondrocytes and adipocytes, but not into myoblasts. Our findings demonstrate that traumatized muscle-derived MPCs exhibit a similar phenotype and resemble MSCs derived from the bone marrow. MPCs harvested from traumatized muscle tissue may be considered for applications in tissue engineering and regenerative medicine following orthopaedic trauma requiring circumferential debridement. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 [Jackson, W. M.; Aragon, A. B.; Djouad, F.; Song, Y.; Koehler, S. M.; Nesti, L. J.; Tuan, R. S.] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Aragon, A. B.; Nesti, L. J.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Tuan, RS (reprint author), NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, 50 S Dr,Room 1140,MSC 8022, Bethesda, MD 20892 USA. EM tuanr@mail.nih.gov OI Djouad, Farida/0000-0001-8248-6822 FU WRAMC [P05-A011]; NIH NIAMS Intramural Research Program [Z01 AR41131] FX This study was supported by the Military Amputee Research Program at WRAMC (Grant No. P05-A011) and the NIH NIAMS Intramural Research Program (Grant No. Z01 AR41131). FACS data were collected at the NIAMS Flow Cytometry Section with the expert assistance of Jim Simone. Portions of this work were performed at the Naval Surgical Research laboratory in the National Naval Medical Center. The authors would like to thank Michael K. Sracic and James R. Bailey for their assistance in performing the differentiation experiments in this study. NR 53 TC 39 Z9 43 U1 1 U2 2 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1932-6254 J9 J TISSUE ENG REGEN M JI J. Tissue Eng. Regen. Med. PD FEB PY 2009 VL 3 IS 2 BP 129 EP 138 DI 10.1002/term.149 PG 10 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology; Engineering, Biomedical SC Cell Biology; Biotechnology & Applied Microbiology; Engineering GA 421VA UT WOS:000264385200008 PM 19170141 ER PT J AU Johnson, ON Gillespie, DL Aidinian, G White, PW Adams, E Fox, CJ AF Johnson, Owen N., III Gillespie, David L. Aidinian, Gilbert White, Paul W. Adams, Eric Fox, Charles J. TI The use of retrievable inferior vena cava filters in severely injured military trauma patients SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID DEEP-VEIN THROMBOSIS; HIGH-RISK; PULMONARY-EMBOLISM; EARLY EXPERIENCE; MULTIPLE TRAUMA; FOLLOW-UP; PREVENTION; THROMBOEMBOLISM; PROPHYLAXIS; MANAGEMENT AB Objective: Important recent data on retrievable inferior vena cava filter (R-IVCF) used in civilian trauma centers suffer from poor follow-up in these transient patients. Because US military casualties can be more easily followed globally, our objective was to further characterize R-IVCF outcomes in a trauma population with improved follow-up. Methods: From July 2003 to June 2007, trauma registry records were retrospectively reviewed for US soldiers injured in Iraq and Afghanistan who had R-IVCF placement. Indications, type of filter, complications, outcomes, and retrieval data were analyzed. Results. Seventy-two R-IVCFs were placed during the study period. Mean follow-up was 28.0 +/- 12.0 months, in 61 (85%) patients. Mean injury severity score (ISS) was 36.3 +/- 10.4 and mean patient age was 27.4 +/- 6.4 years. Fifty-nine R-IVCFs (82%) were not retrieved due to: death (1, 1.3%), technical failure (2, 2.8%), lost to follow-up (11, 15.2%), or contraindications to retrieval (45, 62.5%). Thirteen R-IVCFs were successfully removed, an overall retrieval rate of 18%. Median dwell time of those removed was 47 days (range, 10-94). IVCF indications were prophylactic in 23 (32%) and therapeutic in 49 (68%) cases. Both retrieval failures were due to incorporation into the caval wall, attempted at 90 and 156 days. Deep vein thromboses at the insertion site or pulmonary embolism following R-IVCF placement or removal were not observed. To date, there have been no reports of IVC stenosis or occlusion. Conclusion: R-IVCFs were safely and effectively used in severely injured military trauma patients with high ISS. Despite improved follow-up, overall retrieval remained low, reflecting the civilian experience. Indication, rather than follow-up losses, accounted for the low retrieval rate. Practice patterns for R-IVCF in trauma may need to be re-examined to optimize outcomes. (J Vasc Surg 2009;49:410-6.) C1 [Johnson, Owen N., III; Gillespie, David L.; Aidinian, Gilbert; White, Paul W.; Adams, Eric; Fox, Charles J.] Walter Reed Army Med Ctr, Dept Surg, Peripheral Vasc Surg Serv, Washington, DC 20307 USA. [Gillespie, David L.; Aidinian, Gilbert; White, Paul W.; Adams, Eric; Fox, Charles J.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Div Vasc Surg, Bethesda, MD 20814 USA. RP Johnson, ON (reprint author), Walter Reed Army Med Ctr, Dept Surg, Peripheral Vasc Surg Serv, 6900 Georgia Ave NW,Bldg 2,Ward 5C, Washington, DC 20307 USA. EM Owen.Johnson@amedd.army.mil OI Johnson III, Owen/0000-0001-6497-1285; Gillespie, David/0000-0002-4378-9465 NR 25 TC 22 Z9 23 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD FEB PY 2009 VL 49 IS 2 BP 410 EP 416 DI 10.1016/j.jvs.2008.09.004 PG 7 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 407ND UT WOS:000263370700028 PM 19038528 ER PT J AU Hannah, ST Lester, PB AF Hannah, Sean T. Lester, Paul B. TI A multilevel approach to building and leading learning organizations SO LEADERSHIP QUARTERLY LA English DT Review DE Leadership; Organizational learning; Multilevel; Knowledge catalyst; Knowledge network; Diffusion ID LEADER-MEMBER EXCHANGE; PATH-GOAL THEORY; PSYCHOLOGICAL CONDITIONS; COLLABORATION NETWORKS; COGNITIVE APPROACH; SHARED LEADERSHIP; DECISION-MAKING; SELF-EFFICACY; PERFORMANCE; INFORMATION AB A multilevel model is offered proposing that organizational learning is an interdependent system where effective leaders enact intervention strategies at the individual (micro), network (meso), and systems (macro) levels. We suggest that leaders approach organizational learning by setting the conditions and structure for learning to occur, while limiting direct interference in the actual creative processes. First, leaders may increase the level of developmental readiness of individual followers, thereby increasing their motivation and ability to approach learning experiences and adapt their mental models. These individuals then serve as catalysts of learning within and between social networks. Second, leaders may promote the diffusion of knowledge between these knowledge catalysts within and across social networks through influencing both the structure and functioning of knowledge networks. Finally, leaders may target actions at the systems level to improve the diffusion to, and institutionalization of, knowledge to the larger organization. Published by Elsevier Inc. C1 [Hannah, Sean T.; Lester, Paul B.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Hannah, ST (reprint author), US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. EM Sean.Hannah@usma.edu; Paul.Lester@usma.edu NR 161 TC 48 Z9 48 U1 11 U2 64 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 EI 1873-3409 J9 LEADERSHIP QUART JI Leadersh. Q. PD FEB PY 2009 VL 20 IS 1 SI SI BP 34 EP 48 DI 10.1016/j.leaqua.2008.11.003 PG 15 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 406HH UT WOS:000263285100004 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI My Hope for Peace SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD FEB 1 PY 2009 VL 134 IS 2 BP 83 EP 83 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 400PF UT WOS:000262879900208 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Halliburton's Army: The Long, Strange Tale of a Private, Profitable and Out of Control Texas Oil Company SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 1 U2 3 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD FEB 1 PY 2009 VL 134 IS 2 BP 83 EP 83 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 400PF UT WOS:000262879900167 ER PT J AU Sarkar, D Phibeck, T AF Sarkar, Debjeet Phibeck, Thomas TI The Use of Multiple Intraosseous Catheters in Combat Casualty Resuscitation SO MILITARY MEDICINE LA English DT Article ID FLUID RESUSCITATION; INFUSION; ACCESS AB During the current military engagements in Iraq and Afghanistan, establishing intravenous (IV) access for resuscitation of critically injured casualties remains a persistent challenge. Intraosseous (IO) access has emerged as a viable alternative in resuscitation. In this case report, a 19 year-old male soldier was severely wounded by a roadside bomb in Iraq. Given the heavy initial blood loss, anatomic location of the injuries and gross wound contamination, peripheral IV access could not be established. Instead, multiple IO catheters were used to initiate fluid resuscitation prior to transfer to a combat support hospital. To our knowledge, this is the first report of such extensive usage of IO catheters. Multiple IO catheters can be placed rapidly and safely and may help solve the challenge of establishing vascular access for resuscitation of critically injured casualties. C1 [Sarkar, Debjeet] Brooke Army Med Ctr, San Antonio, TX 78234 USA. [Phibeck, Thomas] Vidacare Corp, San Antonio, TX 78216 USA. RP Sarkar, D (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. NR 21 TC 14 Z9 14 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2009 VL 174 IS 2 BP 106 EP 108 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 601LO UT WOS:000278061200002 PM 19317188 ER PT J AU Morgan, CA Hazlett, G Southwick, S Rasmusson, A Lieberman, HR AF Morgan, Charles A., III Hazlett, Gary Southwick, Steven Rasmusson, Ann Lieberman, Harris R. TI Effect of Carbohydrate Administration on Recovery From Stress-Induced Deficits in Cognitive Function: A Double-Blind, Placebo-Controlled Study of Soldiers Exposed to Survival School Stress SO MILITARY MEDICINE LA English DT Article ID UNCONTROLLABLE STRESS; NEUROPEPTIDE-Y; PERFORMANCE; EXERCISE; HUMANS; MOOD; CAFFEINE; CORTISOL AB Objective: The goal of this project was to evaluate the effects of energy supplementation, as liquid carbohydrate (CHO), on facilitating recovery of cognitive function in soldiers who have been exposed to sustained psychological and physical stress during Survival School Training. Project Design: A double-blind, placebo-controlled design was used. Healthy, male volunteers attending survival training were recruited for participation in the study. At the conclusion of the mock captivity phase of survival training and before a recovery night of sleep, subjects participated in cognitive testing. After this, subjects were randomly assigned to one of three treatment groups. Subjects received either a 6% CHO (35.1 kJ/kg), 12% CHO (70.2 kJ/kg), or placebo beverage in four isovolemic doses. In the morning of the following day, all subjects participated in a second assessment of cognitive functioning. Results: Compared to subjects who received placebo, those who received supplemental CHO beverages exhibited significantly improved performance on a complex cognitive task (i.e., Stroop Test) involving concentration effectiveness associated with selective attention and response inhibition. No differences were observed on a variety of cognitive tasks of lesser complexity. Discussion: These data suggest nutritional interventions enhance the rapid recovery of complex cognitive functions impaired by exposure to significant or sustained stressful conditions. In addition to enhancing speed of recovery of function between operational intervals, the current data suggest that dietary supplement strategies may hold promise for enhancing field performance and a capacity to assist in sustaining operations by military personnel over time. C1 [Morgan, Charles A., III; Southwick, Steven; Rasmusson, Ann] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA. [Morgan, Charles A., III; Southwick, Steven; Rasmusson, Ann] VA New England Hlth Care Syst, Clin Neurosci Div, Natl Ctr PTSD, West Haven, CT 06519 USA. [Hazlett, Gary] Woodard Cody Specialty Consulting Inc, Chapel Hill, NC 27514 USA. [Rasmusson, Ann] Boston Univ, Sch Med, VA Natl Ctr PTSD, Womens Hlth Sci Div,VA Boston Hlth Care Syst, Boston, MA 02130 USA. [Lieberman, Harris R.] USA, Mil Nutr Div, Army Res Inst Environm Med, Natick, MA 01760 USA. RP Morgan, CA (reprint author), Yale Univ, Sch Med, Dept Psychiat, 300 George St, New Haven, CT 06511 USA. FU United States Special Operations Command Biomedical Initiatives Steering Committee FX Funding for this research was provided by a grant to Charles A. Morgan III from the United States Special Operations Command Biomedical Initiatives Steering Committee. NR 25 TC 5 Z9 5 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2009 VL 174 IS 2 BP 132 EP 138 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 601LO UT WOS:000278061200007 PM 19317193 ER PT J AU Zantek, PF Nestler, ST AF Zantek, Paul F. Nestler, Scott T. TI Performance and Properties of Q-Statistic Monitoring Schemes SO NAVAL RESEARCH LOGISTICS LA English DT Article DE quality control; statistical process control; run-length distribution; self-starting method; Monte Carlo integration ID RUN-LENGTH DISTRIBUTIONS; CONTROL CHARTS; ESTIMATED PARAMETERS; MODEL; VARIANCE AB In this article, we study the Shewhart chart of Q statistics proposed for the detection of process mean shifts in start-up processes and short runs. Exact expressions for the run-length distribution of this chart are derived and evaluated using an efficient computational procedure. The procedure can be considerably faster than using direct simulation. We extend our work to analyze the practice of requiring Multiple signals from the chart before responding, a practice sometimes followed with Shewhart charts. The results show that waiting to receive multiple signals severely reduces the probability of quickly detecting shifts in certain cases, and therefore may be considered a risky practice. Operational guidelines for practitioners implementing the chart are discussed. (C) 2009 Wiley Periodicals, Inc. Naval Research Logistics 56: 279-292, 2009 C1 [Zantek, Paul F.] Univ Minnesota, Dept Operat & Management Sci, Carlson Sch Management, Minneapolis, MN 55455 USA. [Nestler, Scott T.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Zantek, PF (reprint author), Univ Minnesota, Dept Operat & Management Sci, Carlson Sch Management, Minneapolis, MN 55455 USA. EM zant0004@umn.edu OI Zantek, Paul/0000-0001-8171-1901 NR 25 TC 5 Z9 5 U1 1 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD FEB PY 2009 VL 56 IS 3 BP 279 EP 292 DI 10.1002/nav.20330 PG 14 WC Operations Research & Management Science SC Operations Research & Management Science GA 421YH UT WOS:000264393700007 ER PT J AU Meurers, BH Zhu, C Fernagut, PO Richter, F Hsia, YC Fleming, SM Oh, M Elashoff, D DiCarlo, CD Seaman, RL Chesselet, MF AF Meurers, B. H. Zhu, C. Fernagut, P. O. Richter, F. Hsia, Y. C. Fleming, S. M. Oh, M. Elashoff, D. DiCarlo, C. D. Seaman, R. L. Chesselet, M. F. TI Low dose rotenone treatment causes selective transcriptional activation of cell death related pathways in dopaminergic neurons in vivo SO NEUROBIOLOGY OF DISEASE LA English DT Article ID UP-REGULATED PROTEIN-1; THIOREDOXIN-INTERACTING PROTEIN; HEAT-SHOCK-PROTEIN; HUMAN COLON-CANCER; PARKINSONS-DISEASE; GENE-EXPRESSION; SUBSTANTIA-NIGRA; OXIDATIVE STRESS; N-MYRISTOYLTRANSFERASE; PEROXISOME PROLIFERATION AB Mitochondrial complex I inhibition has been implicated in the degeneration of midbrain dopaminergic (DA) neurons in Parkinson's disease. However, the mechanisms and pathways that determine the cellular fate of DA neurons downstream of the mitochondrial dysfunction have not been fully identified. We conducted cell-type specific gene array experiments with nigral DA neurons from rats treated with the complex I inhibitor, rotenone, at a dose that does not induce cell death. The genome wide screen identified transcriptional changes in multiple cell death related pathways that are indicative of a simultaneous activation of both degenerative and protective mechanisms. Quantitative PCR analyses of a subset of these genes in different neuronal populations of the basal ganglia revealed that some of the changes are specific for DA neurons, suggesting that these neurons are highly sensitive to rotenone. Our data provide insight into potentially defensive strategies of DA neurons against disease relevant insults. (C) 2008 Elsevier Inc. All rights reserved. C1 [Meurers, B. H.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA. [Chesselet, M. F.] Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA. [Oh, M.; Elashoff, D.] Univ Calif Los Angeles, Dept Publ Hlth, Los Angeles, CA 90095 USA. [DiCarlo, C. D.] SW Fdn Biomed Res, SW Natl Primate Res Ctr, San Antonio, TX 78284 USA. [Seaman, R. L.] USA, Med Res Detachment, McKesson BioServ, Brooks City Base, TX USA. RP Meurers, BH (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, 710 Westwood Plaza, Los Angeles, CA 90095 USA. EM bmeurers@mednet.ucla.edu RI Richter, Franziska/N-8009-2014; OI Richter, Franziska/0000-0003-0803-4398; Fernagut, Pierre-Olivier/0000-0002-7737-5439 FU US Army MRMC [DAMD17-94-C-4069]; Public Health Service [U54 ES12078, P50 NS38367] FX The work was supported by US Army MRMC contract DAMD17-94-C-4069 and Public Health Service awards U54 ES12078 and P50 NS38367. NR 65 TC 17 Z9 17 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0969-9961 J9 NEUROBIOL DIS JI Neurobiol. Dis. PD FEB PY 2009 VL 33 IS 2 BP 182 EP 192 DI 10.1016/j.nbd.2008.10.001 PG 11 WC Neurosciences SC Neurosciences & Neurology GA 403ZM UT WOS:000263120500005 PM 19013527 ER PT J AU Bondugula, R Lee, MS Wallqvist, A AF Bondugula, Rajkumar Lee, Michael S. Wallqvist, Anders TI FIEFDom: a transparent domain boundary recognition system using a fuzzy mean operator SO NUCLEIC ACIDS RESEARCH LA English DT Article ID PROTEIN-STRUCTURE PREDICTION; SECONDARY STRUCTURE; AUTOMATED PREDICTION; SEQUENCE-ANALYSIS; NEURAL-NETWORKS; DATABASE; SERVER; REGIONS; CATH; SCOP AB Protein domain prediction is often the preliminary step in both experimental and computational protein research. Here we present a new method to predict the domain boundaries of a multidomain protein from its amino acid sequence using a fuzzy mean operator. Using the nr-sequence database together with a reference protein set (RPS) containing known domain boundaries, the operator is used to assign a likelihood value for each residue of the query sequence as belonging to a domain boundary. This procedure robustly identifies contiguous boundary regions. For a dataset with a maximum sequence identity of 30, the average domain prediction accuracy of our method is 97 for one domain proteins and 58 for multidomain proteins. The presented model is capable of using new sequence/structure information without re-parameterization after each RPS update. When tested on a current database using a four year old RPS and on a database that contains different domain definitions than those used to train the models, our method consistently yielded the same accuracy while two other published methods did not. A comparison with other domain prediction methods used in the CASP7 competition indicates that our method performs better than existing sequence-based methods. C1 [Bondugula, Rajkumar; Lee, Michael S.; Wallqvist, Anders] USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Lee, Michael S.] USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [Lee, Michael S.] USA, Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Ft Detrick, MD 21702 USA. RP Bondugula, R (reprint author), USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM raj@bioanalysis.org OI wallqvist, anders/0000-0002-9775-7469 FU U. S. Department of Defense High Performance Computing Modernization Program, under the High Performance Computing Software Applications Institutes initiative FX This work was supported by the U. S. Department of Defense High Performance Computing Modernization Program, under the High Performance Computing Software Applications Institutes initiative. Funding for open access charge is same as funding for work. NR 50 TC 13 Z9 13 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0305-1048 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD FEB PY 2009 VL 37 IS 2 BP 452 EP 462 DI 10.1093/nar/gkn944 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 401SW UT WOS:000262963400022 PM 19056827 ER PT J AU McClung, JP Karl, JP AF McClung, James P. Karl, J. Philip TI Iron deficiency and obesity: the contribution of inflammation and diminished iron absorption SO NUTRITION REVIEWS LA English DT Review DE hepcidin; inflammation; iron; obesity ID PREVIOUSLY UNTRAINED WOMEN; CONTROLLED-TRIAL; DOUBLE-BLIND; FERRIC PYROPHOSPHATE; DUAL FORTIFICATION; OVERWEIGHT; ADOLESCENTS; CHILDREN; ANEMIA; CAPACITY AB Poor iron status affects billions of people worldwide. The prevalence of obesity continues to rise in both developed and developing nations. An association between iron status and obesity has been described in children and adults. The mechanism explaining this relationship remains unknown; however, findings from recent reports suggest that body mass index and inflammation predict iron absorption and affect the response to iron fortification. The relationship between inflammation and iron absorption may be mediated by hepcidin, although further studies will be required to confirm this potential physiological explanation for the increased prevalence of iron deficiency in the obese. C1 [McClung, James P.; Karl, J. Philip] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP McClung, JP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM James.McClung@amedd.army.mil RI McClung, James/A-1989-2009; OI Karl, J. Philip/0000-0002-5871-2241 NR 33 TC 64 Z9 68 U1 0 U2 8 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0029-6643 J9 NUTR REV JI Nutr. Rev. PD FEB PY 2009 VL 67 IS 2 BP 100 EP 104 DI 10.1111/j.1753-4887.2008.00145.x PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 397VB UT WOS:000262689100005 PM 19178651 ER PT J AU Reed, J Sridhara, S Brietzke, SE AF Reed, Jeremy Sridhara, Shankar Brietzke, Scott E. TI Electrocautery adenoidectomy outcomes: A meta-analysis SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review ID SUCTION-DIATHERMY; RISK AB OBJECTIVE: Review the published literature regarding clinical outcomes of suction electrocautery adenoidectomy (ECA) in pediatric patients. DATA SOURCE: The MEDLINE database was systematically reviewed for articles reporting on the use of ECA. REVIEW METHODS: Each study was independently reviewed by each investigator. Inclusion criteria included English language, sample size greater than five, and presentation of extractable data regarding outcomes with ECA. Random-effects modeling was used to estimate summary outcomes. RESULTS: Nine studies met the inclusion criteria. The mean sample size was 276 patients with a grand mean age of 6.0 years. Random-effects modeling of intraoperative hemorrhage (4.1 cc vs 24.0 cc, 95 percent CI of difference = 16.5-23.1, P < 0.001) and operative time (10.0 minutes vs 18.4 minutes. 95 percent CI of difference = 0.82-2.90. P < 0.001) favored ECA vs curette adenoidectomy. Subjective success was reported in 95.0 percent (95% CI = 92.7%-97.3%, P < 0.001) of ECA patients with a grand mean of 5.8 months of follow-up. Adenoid regrowth was evaluated objectively (endoscopy or x ray) in only 116 of 2132 patients (5.4%), with an observed regrowth rate of 2.8 percent that (95%n CI = 0%-5.5%, P = 0.052). CONCLUSIONS: The preponderance of available evidence favors ECA vs curette adenoidectomy in terms of decreased intraoperative hemorrhage and operative time. Long-term outcome data for ECA are scarce but suggest a low regrowth and complication rate. C1 [Reed, Jeremy; Sridhara, Shankar; Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Deptartment Otolaryngol, 6900 Georgia Ave, Washington, DC 20307 USA. EM Scott.brietzke@amedd.army.mil OI Brietzke, Scott/0000-0002-2844-6026 NR 14 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD FEB PY 2009 VL 140 IS 2 BP 148 EP 153 DI 10.1016/j.otohns.2008.11.030 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 404LL UT WOS:000263153500002 PM 19201279 ER PT J AU Genovese, RF Mioduszewski, RJ Benton, BJ Pare, MA Cooksey, JA AF Genovese, Raymond F. Mioduszewski, Robert J. Benton, Bernard J. Pare, Matthew A. Cooksey, Jessica A. TI Behavioral evaluation of rats following low-level inhalation exposure to sarin SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE Nerve agent; Spatial memory; Operant behavior; Radial maze; Cognitive deficit ID RADIAL ARM MAZE; NERVOUS-SYSTEM; PHYSOSTIGMINE; SCOPOLAMINE; CYCLOSARIN; DURATION; SAMPLES; VAPOR AB We evaluated the effects, in rats, of single and multiple low-level inhalation exposures to sarin. Rats were trained on a variable-interval, 56 s (VI56) schedule of food reinforcement and then exposed to sarin vapor (1.7-4.0 mg/m(3) x 60 min) or air control. The exposures did not produce clinical signs of toxicity other than miosis. Subsequently, performance on the VI56 and acquisition of a radial-arm maze spatial memory task was evaluated over approximately 11 weeks. Single exposures did not affect performance on the VI56 and had little effect on acquisition of the radial-arm maze task. Multiple exposures (4.0 mg/m(3) x 60 min/day x 3) disrupted performance on the VI56 schedule during the initial post-exposure sessions. The disruption, however, resolved after several days. Multiple exposures also produced a deficit on the radial-arm maze task in that sarin-exposed rats tended to take it longer to complete the maze and to make more errors. The deficit, however, resolved during the first three weeks of acquisition. These results demonstrate that in rats, inhalation exposure to sarin at levels below those causing overt signs of clinical toxicity can produce cognitive and performance deficits. Furthermore, the observed deficits do not appear to be persistent. Published by Elsevier Inc. C1 [Genovese, Raymond F.; Pare, Matthew A.; Cooksey, Jessica A.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Mioduszewski, Robert J.; Benton, Bernard J.] USA, Edgewood Chem Biol Ctr, Operat Toxicol Team, Aberdeen Proving Ground, MD USA. RP Genovese, RF (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM Raymond.Genovese@US.Army.Mil NR 29 TC 4 Z9 4 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD FEB PY 2009 VL 91 IS 4 BP 517 EP 525 DI 10.1016/j.pbb.2008.09.006 PG 9 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA 411FI UT WOS:000263633900006 PM 18835292 ER PT J AU Chen, JYC AF Chen, Jessie Y. C. TI Concurrent Performance of Military and Robotics Tasks and Effects of Cueing in a Simulated Multi-Tasking Environment SO PRESENCE-TELEOPERATORS AND VIRTUAL ENVIRONMENTS LA English DT Article AB We simulated a military mounted crewstation environment and conducted two experiments to examine the workload and performance of the combined position of gunner and robotics operator. The robotics tasks involved managing a semi-autonomous ground robot or teleoperating a ground robot to conduct reconnaissance tasks. We also evaluated whether aided target recognition (AiTR) capabilities (delivered either through tactile or tactile + visual cueing) for the gunnery task might benefit the concurrent robotics and communication tasks. Results showed that participants' gunnery task performance degraded significantly when they had to concurrently monitor, manage, or teleoperate an unmanned ground vehicle compared to the gunnery-single task condition. When there was AiTR to assist them with their gunnery task, operators' concurrent performance of robotics and communication tasks improved significantly. However, there was a tendency for participants to over-rely on automation when task load was heavy, and performance degradations were observed in instances where automation failed to be entirely reliable. Participants' spatial ability was found to be a reliable predictor of robotics task performance, although the performance gap between those with higher and lower spatial ability appeared to be narrower when the AiTR was available to assist the gunnery task. Participants' perceived workload increased consistently as the concurrent task conditions became more challenging and when their gunnery task was unassisted. Individual difference factors such as spatial ability and perceived attentional control were found to correlate significantly with some of the performance measures. Implications for military personnel selection were discussed. C1 USA, Res Lab, Human Res & Engn Directorate, Orlando, FL 32826 USA. RP Chen, JYC (reprint author), USA, Res Lab, Human Res & Engn Directorate, 12423 Res Pkwy, Orlando, FL 32826 USA. EM jessie.chen@us.army.mil FU U.S. Army's Robotics Collaboration Army Technology Objective; U.S. Army Research Laboratory (ARL); Human Research & Engineering Directorate (HRED); U.S. Army RDECOM-Simulation & Training Technology Center; ARL; U.S. Army Research Institute; UCF-Institute for Simulation Training FX This project was funded by the U.S. Army's Robotics Collaboration Army Technology Objective. I would like to thank Mr. Michael J. Barnes of the U.S. Army Research Laboratory (ARL), Human Research & Engineering Directorate (HRED) for his guidance throughout the process of this research project. I would like to acknowledge Major Carla Joyner of the U.S. Military Academy and Dr. Peter Terrence of State Farm Insurance for their contributions to this research. I would also like to thank U.S. Army RDECOM-Simulation & Training Technology Center, Dr. Jon Bornstein's group of ARL, Dr. Paula Durlach of the U.S. Army Research Institute, and UCF-Institute for Simulation & Training for their support. NR 28 TC 5 Z9 5 U1 2 U2 5 PU M I T PRESS PI CAMBRIDGE PA 238 MAIN STREET, STE 500, CAMBRIDGE, MA 02142-1046 USA SN 1054-7460 J9 PRESENCE-TELEOP VIRT JI Presence-Teleoper. Virtual Env. PD FEB PY 2009 VL 18 IS 1 BP 1 EP 15 DI 10.1162/pres.18.1.1 PG 15 WC Computer Science, Cybernetics; Computer Science, Software Engineering SC Computer Science GA 403ZZ UT WOS:000263121800001 ER PT J AU Yu, CG Zavaijevski, N Desai, V Reifman, J AF Yu, Chenggang Zavaijevski, Nela Desai, Valmik Reifman, Jaques TI Genome-wide enzyme annotation with precision control: Catalytic families [CatFam] databases SO PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS LA English DT Article DE catalytic function; automated annotation; Enzyme Commission number; profile method; protein function prediction ID PROTEIN FUNCTION; SEQUENCE ANNOTATION; PREDICTION; PROFILES; PRORULE; EFICAZ; MODELS AB In this article, we present a new method termed CatFam (Catalytic Families) to automatically infer the functions of catalytic proteins, which account for 20-40% of all proteins in living organisms and play a critical role in a variety of biological processes. CatFam is a sequence-based method that generates sequence profiles to represent and infer protein catalytic functions. CatFam generates profiles through a stepwise procedure that carefully controls profile quality and employs nonenzymes as negative samples to establish profile-specific thresholds associated with a predefined nominal false-positive rate (FPR) of predictions. The adjustable FPR allows for fine precision control of each profile and enables the generation of profile databases that meet different needs: function annotation with high precision and hypothesis generation with moderate precision but better recall. Multiple tests of CatFam databases (generated with distinct nominal FPRs) against enzyme and nonenzyme datasets show that the method's predictions have consistently high precision and recall. For example, a 1% FPR database predicts protein catalytic functions for a dataset of enzymes and nonenzymes with 98.6% precision and 95.0% recall. Comparisons of CatFam databases against other established profile-based methods for the functional annotation of 13 bacterial genomes indicate that CatFam consistently achieves higher precision and (in most cases) higher recall, and that (on average) CatFam provides 21.9% additional catalytic functions not inferred by the other similarly reliable methods. These results strongly suggest that the proposed method provides a valuable contribution to the automated prediction of protein catalytic functions. The CatFam databases and the database search program are freely available at http://www.bhsai.org/downloads/catfam.tar.gz. C1 [Yu, Chenggang; Zavaijevski, Nela; Desai, Valmik; Reifman, Jaques] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.miil FU The US Department of Defense High Performance Computing Modernization Program; High performance Computing Software Applications Institutes (HSAI) initiative FX Grant sponsor: The US Department of Defense High Performance Computing Modernization Program, under the High performance Computing Software Applications Institutes (HSAI) initiative. NR 39 TC 25 Z9 25 U1 0 U2 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0887-3585 J9 PROTEINS JI Proteins PD FEB 1 PY 2009 VL 74 IS 2 BP 449 EP 460 DI 10.1002/prot.22167 PG 12 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 389NR UT WOS:000262100800015 PM 18636476 ER PT J AU Warner, CH Appenzeller, GN Warner, CM Grieger, T AF Warner, Christopher H. Appenzeller, George N. Warner, Carolynn M. Grieger, Thomas TI Psychological Effects of Deployments of Military Families SO PSYCHIATRIC ANNALS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; OPERATION DESERT-STORM; PERSIAN-GULF; SOLDIERS; VETERANS; SPOUSES; WAR; COMBAT; WIVES C1 [Warner, Christopher H.] USA, Dept Behav Hlth, Winn Army Community Hosp, Ft Stewart, GA 31314 USA. [Appenzeller, George N.] USA, Clin Serv, Winn Army Community Hosp, Ft Stewart, GA 31314 USA. [Grieger, Thomas] Uniformed Serv Univ Hlth Sci, USN, Dept Psychiat, Bethesda, MD 20814 USA. RP Warner, CH (reprint author), USA, Dept Behav Hlth, Winn Army Community Hosp, Ft Stewart, GA 31314 USA. NR 25 TC 23 Z9 23 U1 1 U2 4 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0048-5713 J9 PSYCHIAT ANN JI Psychiatr. Ann. PD FEB PY 2009 VL 39 IS 2 BP 56 EP 63 PG 8 WC Psychiatry SC Psychiatry GA 411EW UT WOS:000263632100005 ER PT J AU Landau, ME Barner, KC AF Landau, Mark E. Barner, Kristen C. TI Vestibulocochlear Nerve SO SEMINARS IN NEUROLOGY LA English DT Article DE Vestibulocochlear nerve; cranial nerve; vertigo; acoustic; nystagmus ID PAROXYSMAL POSITIONAL VERTIGO; CANALITH REPOSITIONING PROCEDURE; MENIERES-DISEASE; RANDOMIZED-TRIAL; DEHISCENCE SYNDROME; HEARING-LOSS; DIZZINESS AB The vestibulocochlear or eighth cranial nerve (CN VIII) has purely special sensory afferent function. The nerve has two components, the vestibular nerve, that detects head and body motion, and the cochlear nerve that detects sound. The primary receptors that convey information to the vestibular portion of CN VIII are the semicircular canals that detect angular acceleration, and the otolithic organs that detect linear acceleration. The organ of Corti receives auditory signals and conveys its information via the cochlear portion. Processes that affect the receptors or the nerve will cause hearing loss, tinnitus, otalgia, vertigo, oscillopsia, and disequilibrium. In this review, the authors discuss the anatomy of CN VIII, the clinical evaluation of patients with vertigo and hearing loss, and specific disease entities. C1 [Landau, Mark E.; Barner, Kristen C.] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. RP Landau, ME (reprint author), Walter Reed Army Med Ctr, Dept Neurol, 6900 Georgia Ave, Washington, DC 20307 USA. EM Mark.Landau@amedd.army.mil NR 39 TC 2 Z9 2 U1 1 U2 1 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 0271-8235 J9 SEMIN NEUROL JI Semin. Neurol. PD FEB PY 2009 VL 29 IS 1 BP 66 EP 73 DI 10.1055/s-0028-1124024 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA 442WR UT WOS:000265871900009 PM 19214934 ER PT J AU Killgore, WDS Kahn-Greene, ET Grugle, NL Killgore, DB Balkin, TJ AF Killgore, William D. S. Kahn-Greene, Ellen T. Grugle, Nancy L. Killgore, Desiree B. Balkin, Thomas J. TI Sustaining Executive Functions During Sleep Deprivation: A Comparison of Caffeine, Dextroamphetamine, and Modafinil SO SLEEP LA English DT Article DE Sleep deprivation; stimulants; caffeine; modafinil; dextroamphetamine; executive function; prefrontal cortex; problem solving; tower; Wisconsin Card Sorting Test ID CARD SORTING TEST; POSITRON-EMISSION-TOMOGRAPHY; FRONTAL-LOBE FUNCTION; WORKING-MEMORY; DECISION-MAKING; LONDON TASK; COGNITIVE PERFORMANCE; PREFRONTAL CORTEX; RECOVERY SLEEP; 24 H AB Objectives: Stimulant medications appear effective at restoring simple alertness and. psychomotor vigilance in sleep deprived individuals, but it is not clear whether these medications are effective at restoring higher order complex cognitive capacities such as planning, sequencing, and decision making. Design: After 44 hours awake, participants received a double-blind dose of one of 3 stimulant medications or placebo. After 45-50 hours awake, participants were tested on computerized versions of the 5-Ring Tower of Hanoi (TOH), the Tower of London (TOL), and the Wisconsin Card Sorting Test (WCST). Setting: In-residence sleep-laboratory facility at the Walter Reed Army Institute of Research. Participants: Fifty-four healthy adults (29 men, 25 women), ranging in age from 18 to 36 years. Interventions: Participants were randomly assigned to 1 of 3 stimulant medication groups, including caffeine, 600 mg (n = 12), modafinil, 400 mg (n = 12), dextroamphetamine, 20 mg (n = 16), or placebo (n = 14). Measurements and Results: At the doses tested, modafinil and dextroamphetamine groups completed the TOL task in significantly fewer moves than the placebo group, and the modafinil group demonstrated greater deliberation before making moves. In contrast, subjects receiving caffeine completed the TOH in fewer moves than all 3 of the other groups, although speed of completion was not influenced by the stimulants. Finally, the modafinil group outperformed all other groups on indices of perseverative responding and perseverative errors from the WCST Conclusions: Although comparisons across tasks cannot be made due to the different times of administration, within-task comparisons suggest that, at the doses tested here, each stimulant may produce differential advantages depending on the cognitive demands of the task. C1 [Killgore, William D. S.; Kahn-Greene, Ellen T.; Grugle, Nancy L.; Killgore, Desiree B.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Killgore, WDS (reprint author), Harvard Univ, McLean Hosp, Sch Med, Neuroimaging Ctr, 115 Mill St, Belmont, MA 02478 USA. EM killgore@mclean.harvard.edu NR 70 TC 45 Z9 48 U1 3 U2 24 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD FEB 1 PY 2009 VL 32 IS 2 BP 205 EP 216 PG 12 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 400TA UT WOS:000262890300012 PM 19238808 ER PT J AU Feng, WJ Pan, E Wang, X Gazonas, GA AF Feng, W. J. Pan, E. Wang, X. Gazonas, G. A. TI A second-order theory for magnetoelectroelastic materials with transverse isotropy SO SMART MATERIALS & STRUCTURES LA English DT Article ID ELECTRO-ELASTIC PLATES; 3-DIMENSIONAL GREENS-FUNCTIONS; PIEZOELECTRIC MATERIALS; COMPOSITE-MATERIALS; INTERFACE CRACK; SOLIDS; WAVES; INCLUSION; BEHAVIOR; MEDIA AB In this paper, we concentrate on the basic governing equations of three-dimensional problems in transversely isotropic and nonlinear magnetoelectroelastic materials (i.e., 6 (m) under bar (m) under bar magnetic crystals). We place emphasis on developing the nonlinear and fully coupled constitutive relations between extended traction (including elastic stress, polarization and magnetization) and extended strain (including elastic strain, electric field and magnetic induction). Simplified results are also presented for the corresponding small deformation problems in the case of both strong magnetic and electric fields and in the case of both weak magnetic and electric fields. The derived concise equations are important in investigating the nonlinear magnetoelectric effects of novel magnetoelectroelastic materials. C1 [Feng, W. J.; Pan, E.; Wang, X.] Univ Akron, Dept Civil Engn, Akron, OH 44329 USA. [Feng, W. J.; Pan, E.; Wang, X.] Univ Akron, Dept Appl Math, Akron, OH 44329 USA. [Feng, W. J.] Shijiazhuang Railway Inst, Dept Engn Mech, Shijiazhuang 050043, Peoples R China. [Gazonas, G. A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Feng, WJ (reprint author), Univ Akron, Dept Civil Engn, Akron, OH 44329 USA. RI Pan, Ernian/F-4504-2011; OI Pan, Ernian/0000-0001-6640-7805; Gazonas, George/0000-0002-2715-016X FU Natural Science Fund of China [10772123]; AFRL/ARL FX The authors would like to thank the Editor and the reviewers for their constructive comments. Partial support from the Natural Science Fund of China (10772123) and AFRL/ARL are also acknowledged. NR 57 TC 5 Z9 5 U1 1 U2 5 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 J9 SMART MATER STRUCT JI Smart Mater. Struct. PD FEB PY 2009 VL 18 IS 2 AR 025001 DI 10.1088/0964-1726/18/2/025001 PG 8 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA 396HM UT WOS:000262582800010 ER PT J AU Johnson, KJ Minor, CP Guthrie, VN Rose-Pehrsson, SL AF Johnson, Kevin J. Minor, Christian P. Guthrie, Verner N. Rose-Pehrsson, Susan L. TI Intelligent data fusion for wide-area assessment of UXO contamination SO STOCHASTIC ENVIRONMENTAL RESEARCH AND RISK ASSESSMENT LA English DT Article DE Wide-area; UXO; Data fusion; Feature selection ID PARTIALLY SUPERVISED CLASSIFICATION; UNEXPLODED ORDNANCE; LAND-COVER; MAGNETOMETRY; IMAGES AB The remediation of sites contaminated with unexploded ordnance (UXO) remains an area of intense focus for the Department of Defense. Under the sponsorship of SERDP, data fusion techniques are being developed for use in enhancing wide-area assessment UXO remediation efforts and a data fusion framework is being created to provide a cohesive data management and decision-making utility to allow for more efficient expenditure of time, labor and resources. An important first step in this work is the development of feature extraction utilities and feature probability density maps for eventual input to data fusion algorithms, making data fusion of estimates of data quality, UXO-related features, non-UXO backgrounds, and correlations among independent data streams possible. Utilizing data acquired during ESTCP's Wide-Area Assessment Pilot Program, the results presented here successfully demonstrate the feasibility of automated feature extraction from light detection and ranging, orthophotography, and helicopter magnetometry wide-area assessment survey data acquired at the Pueblo Precision Bombing Range #2. These data were imported and registered to a common survey map grid and UXO-related features were extracted and utilized to construct survey site-wide probability density maps that are well-suited for input to higher level data fusion algorithms. Preliminary combination of feature maps from the various data sources yielded maps for the Pueblo site that offered a more accurate UXO assessment than any one data source alone. C1 [Johnson, Kevin J.; Rose-Pehrsson, Susan L.] USN, Res Lab, Washington, DC 20375 USA. [Minor, Christian P.] Nova Res Inc, Alexandria, VA 22308 USA. [Guthrie, Verner N.] USA, Topog Engn Ctr, Alexandria, VA 22315 USA. RP Rose-Pehrsson, SL (reprint author), USN, Res Lab, Washington, DC 20375 USA. EM susan.rosepehrsson@nrl.navy.mil FU Strategic Environmental Research and Development Program (SERDP) [MM-1510] FX This work is funded by the Strategic Environmental Research and Development Program (SERDP) under Project MM-1510. The researchers would like to thank Dr Anne Andrews and Dr Herb Nelson for their invaluable expertise with survey data, and the survey teams that participated in ESTCP Wide-Area Assessment Pilot Program, without which there would be no data for data fusion efforts. NR 35 TC 6 Z9 6 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1436-3240 J9 STOCH ENV RES RISK A JI Stoch. Environ. Res. Risk Assess. PD FEB PY 2009 VL 23 IS 2 BP 237 EP 252 DI 10.1007/s00477-007-0204-4 PG 16 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences; Statistics & Probability; Water Resources SC Engineering; Environmental Sciences & Ecology; Mathematics; Water Resources GA 392QH UT WOS:000262316800009 ER PT J AU Wells, GD AF Wells, G. Damon TI The Post-Workout Protein Puzzle: Which Protein Packs the Most Punch? SO STRENGTH AND CONDITIONING JOURNAL LA English DT Article DE protein; amino acids; post-workout; leucine; glutamine ID RESISTANCE EXERCISE; SKELETAL-MUSCLE; ENDURANCE EXERCISE; COMBINED INGESTION; DIETARY-PROTEIN; AMINO-ACIDS; YOUNG MEN; RECOVERY; LEUCINE; CONSUMPTION AB Current research on protein supplementation has focused on the effectiveness of post-workout (PWO) consumption of specific proteins and/or amino acids. Further research shows that PWO protein supplementation can significantly increase skeletal muscle protein synthesis and reduce protein breakdown in muscles, especially if intake is timed properly. Whole foods, protein supplements, and amino acid supplements are the primary sources of PWO protein. Most commercially available protein supplements are produced from sources such as milk, egg albumin, soy, wheat, and collagen. This article examines the wide variety of protein sources and proposes a comprehensive guide for strength and conditioning coaches. C1 US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. RP Wells, GD (reprint author), US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. NR 23 TC 0 Z9 0 U1 2 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-1602 J9 STRENGTH COND J JI Strength Cond. J. PD FEB PY 2009 VL 31 IS 1 BP 27 EP 30 DI 10.1519/SSC.0b013e3181956b8b PG 4 WC Sport Sciences SC Sport Sciences GA 614PE UT WOS:000279071400004 ER PT J AU Lanier, CR AF Lanier, Clinton R. TI Analysis of the Skills Called for by Technical Communication Employers in Recruitment Postings SO TECHNICAL COMMUNICATION LA English DT Article AB Provides a framework of experiences and skills employers call for in job postings Shows that potential employers are seeking very technical or domain-specific knowledge from technical writers Shows that specific technology tool skills are less important to employers than more basic technical writing skills. C1 [Lanier, Clinton R.] USA, Res Lab, Washington, DC USA. NR 20 TC 10 Z9 10 U1 0 U2 2 PU SOC TECHNICAL COMMUNICATION PI ARLINGTON PA 901 NORTH STUART ST, STE 904, ARLINGTON, VA 22203 USA SN 0049-3155 J9 TECH COMMUN JI Tech. Commun. PD FEB PY 2009 VL 56 IS 1 BP 51 EP 61 PG 11 WC Communication SC Communication GA 407DY UT WOS:000263345000006 ER PT J AU Yoosuf, AA Shiham, I Mohamed, AJ Ali, G Luna, JM Pandav, R Gongal, GN Nisaluk, A Jarman, RG Gibbons, RV AF Yoosuf, Abdul Azeez Shiham, Ibrahim Mohamed, Ahmed Jamsheed Ali, Geela Luna, J. M. Pandav, R. Gongal, G. N. Nisaluk, Ananda Jarman, Richard G. Gibbons, Robert V. TI First report of chikungunya from the Maldives SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE Chikungunya virus; Dengue; Arboviruses; Aedes; Epidemics; Indian Ocean Islands ID REUNION ISLAND; EPIDEMIC; DENGUE; OUTBREAK; VIRUSES; INDIA AB An outbreak, characterised by fever, arthralgia and myalgia, in Male and other islands of the Maldives began in December 2006. The illness was suspected as being due to chikungunya virus based on clinical symptoms and the prevailing chikungunya epidemic in the Indian Ocean region. The Department of Public Health initiated an investigation and collected blood samples from 67 patients; 21% were IgM-positive for chikungunya and 96% were PCR-positive. Six percent were positive for dengue by enzyme immunosorbent assay and 4% had evidence of dual infection. This is the first time that chikungunya fever has been confirmed in the Maldives. A total of 11879 suspected and confirmed cases affecting 61% of inhabited islands (attack rate ranging from 0% to 72% on individual islands) were reported by the end of the epidemic in April 2007. Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene. C1 [Yoosuf, Abdul Azeez; Ali, Geela] Minist Hlth, Male 20379, Maldives. [Shiham, Ibrahim; Mohamed, Ahmed Jamsheed] Indira Gandhi Mem Hosp, Male, Maldives. [Gongal, G. N.] Reg Off SE Asia, New Delhi 110002, India. [Nisaluk, Ananda; Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Gibbons, RV (reprint author), AFRIMS, USAMC, APO, AP 96546 USA. EM robert.gibbons@afrims.org NR 14 TC 20 Z9 20 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD FEB PY 2009 VL 103 IS 2 BP 192 EP 196 DI 10.1016/j.trstmh.2008.09.006 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 407XD UT WOS:000263396700014 PM 18930301 ER PT J AU Cardo, LJ Salata, J Wilder, D AF Cardo, Lisa J. Salata, Jeanne Wilder, Donna TI Removal of Plasmodium falciparum-infected red blood cells from whole blood by leukoreduction filters SO TRANSFUSION LA English DT Article ID MEMBRANE PHOSPHOLIPID ASYMMETRY; ERYTHROCYTE PHOSPHATIDYLSERINE EXPOSURE; LEUKODEPLETION FILTERS; LEUKOCYTE DEPLETION; HYPERCOAGULABLE STATE; TRYPANOSOMA-CRUZI; ENDOTHELIAL-CELLS; DONOR BLOOD; MALARIA; TRANSFUSION AB There has been an unexplained decrease in the incidence of transfusion-transmitted malaria in recent years. The decrease in incidence has paralleled the increasing use of leukoreduction filters. Malaria-infected red blood cells (RBCs) share surface characteristics of hemoglobin S-containing cells. Because units collected from donors with sickle trait do not filter optimally due to adherence of RBCs to the filters, the possibility that malaria-infected RBCs may also adhere to filters was investigated. Malaria-infected whole blood or calcium ionophore (A25187)-treated and control RBCs were filtered with leukoreduction filters. Quantitation of malaria-infected RBCs before and after filtration was performed by flow cytometry to determine the presence of DNA within RBCs, indicating malaria infection. Annexin V binding was also determined before and after filtration of RBCs treated with A25187. Immediately after filtration, filters were fixed and examined by scanning and transmission electron microscopy. There were at least three configurations of adherence of malaria-infected RBCs demonstrated within the filters. The first was direct adherence of infected RBCs to filter fibers; the second involved adherence of malaria-infected RBCs to platelets, which were adherent to filter fibers; and the third was adherence of infected RBCs to other RBCs. Filtration also resulted in preferential removal of phosphatidylserine (PS)-expressing cells as seen by the reduction of annexin V binding after filtration. This was further confirmed by electron micrographic examination of the filters in which untreated RBCs sit within the filter resting on top of filter fibers; however, calcium ionophore-treated RBCs are seen to cling tightly to the fibers. PS expression by RBCs leads to their adherence within leukoreduction filters. Malaria-infected RBCs are retained via more than one mechanism. The efficiency of removal requires further study. C1 Walter Reed Army Inst Res, Transfus Med Branch, Silver Spring, MD USA. RP Cardo, LJ (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM lisa.cardo@us.army.mil NR 43 TC 5 Z9 5 U1 1 U2 4 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD FEB PY 2009 VL 49 IS 2 BP 337 EP 346 DI 10.1111/j.1537-2995.2008.01974.x PG 10 WC Hematology SC Hematology GA 397XT UT WOS:000262696400022 PM 19389214 ER PT J AU Mores, CN Turell, MJ Dyer, J Rossi, CA AF Mores, Christopher N. Turell, Michael J. Dyer, Jessie Rossi, Cindi A. TI Phylogenetic Relationships Among Orthobunyaviruses Isolated from Mosquitoes Captured in Peru SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Orthobunyavirus; Bunyamwera; arbovirus; NSs; Phylogenetic analysis ID CALIFORNIA SEROGROUP VIRUSES; NONSTRUCTURAL PROTEIN NSS; ARTHROPOD-BORNE VIRUSES; MEDIUM RNA SEGMENT; BUNYAMWERA GROUP; GROUP-C; SIMBU SEROGROUP; OROPOUCHE VIRUS; SEQUENCE; BUNYAVIRIDAE AB The Orthobunyavirus genus of the family Bunyaviridae is comprised of over 220 extremely diverse viral species. Members of this genus are often associated with acute febrile illness in animals and humans. As part of a long-term study of the ecology of arboviruses in the Amazon basin of Peru, we have isolated over 60 orthobunyaviruses from mosquitoes. The identification of many of these isolates by fluorescent antibody assay has been confounded by the lack of specificity of many available reagents. Therefore, we initiated genetic characterization, based on the S and M genomic segments, of selected viral isolates. Based on comparisons of the nucleotide sequences of the nucleocapsid gene, Wyeomyia, a virus in the Bunyamwera group, was the most related Orthobunyavirus species. Within the nonstructural S (NSs) open reading frame of the S segment, we found four conserved stop codons for the Peruvian isolates. Detailed comparisons of Bunyamwera, Simbu viruses, Group C viruses, and California viruses revealed all four of these NSs stop codons only appeared in Wyeomyia and the Peruvian isolates, and Guaroa conserved one of these stop codons. Such an apparent obliteration of the native NSs protein has not been described. Analysis of partial M segment amino acid sequence supports the conclusion that the viruses in this study are members of an uncharacterized orthobunyavirus group. C1 [Mores, Christopher N.] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA. [Mores, Christopher N.; Turell, Michael J.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Dyer, Jessie] Tulane Univ, Dept Mol & Cellular Biol, New Orleans, LA 70118 USA. [Rossi, Cindi A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Mores, CN (reprint author), Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA. EM cmores@lsu.edu NR 32 TC 6 Z9 6 U1 1 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD FEB PY 2009 VL 9 IS 1 BP 25 EP 32 DI 10.1089/vbz.2008.0030 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 407SY UT WOS:000263385800004 PM 18759638 ER PT J AU Perovich, DK Grenfell, TC Light, B Elder, BC Harbeck, J Polashenski, C Tucker, WB Stelmach, C AF Perovich, Donald K. Grenfell, Thomas C. Light, Bonnie Elder, Bruce C. Harbeck, Jeremy Polashenski, Christopher Tucker, Walter B., III Stelmach, Casey TI Transpolar observations of the morphological properties of Arctic sea ice SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID MASS-BALANCE; PHYSICAL-PROPERTIES; FRAM STRAIT; SUMMER; THICKNESS; ALBEDO; OCEAN; COVER; SOOT; SNOW AB During the 5 August to 30 September 2005 Healy Oden Trans-Arctic Expedition a trans-Arctic survey of the physical properties of the polar ice pack was conducted. The observational program consisted of four broad classes of snow and ice characterization activities: observations made while the ship was in transit, ice station measurements, helicopter survey flights, and the deployment of autonomous ice mass balance buoys. Ice conditions, including ice thicknesses, classes, and concentrations of primary, secondary, and tertiary categories were reported at 2-hour intervals. Pond fractions were large early in the cruise at the southern edge of the ice pack, reaching peak values of 0.5 and averaging 0.25. Ice concentrations ranged from 0.8 to 1.0 north of 79 degrees N, save for an area between 88 degrees 30'N and 89 degrees 30'N, where polynyas and thin ice were observed. Surveys of snow depth, ice thickness, and ice properties were conducted at ice stations. Thickness observations suggest a general latitudinal trend of increasing ice thickness moving northward, with considerable variability from floe to floe and within a single floe. Average floe thicknesses varied from 1.0 to > 2.8 m, and the standard deviation of thickness on an individual floe was as large as 1 m. Ice crystallography showed a large amount of granular ice. The average optical-equivalent soot content was 4 ng C g(-1) for new snow, 8 ng C g(-1) for the surface granular layer of multiyear ice, and 18 ng C g (-1) for the interior of multiyear ice, indicating a tendency of the particulates to concentrate at the surface with melting. C1 [Perovich, Donald K.; Elder, Bruce C.] Erdc, CRREL, Hanover, NH 03755 USA. [Light, Bonnie] Univ Washington, Polar Sci Ctr, Seattle, WA 98125 USA. [Grenfell, Thomas C.] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA. [Harbeck, Jeremy] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. [Polashenski, Christopher; Stelmach, Casey] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Tucker, Walter B., III] Terry Tucker Res, Enfield, NH 03748 USA. RP Perovich, DK (reprint author), Erdc, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM donald.k.perovich@erdc.usace.army.mil FU National Science Foundation; Office of Polar Programs; Arctic Natural Sciences FX The authors thank the crew of the USCGC icebreaker Healy for their indefatigable assistance during the cruise. This work was funded by the National Science Foundation, Office of Polar Programs, Arctic Natural Sciences. NR 44 TC 41 Z9 43 U1 0 U2 14 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JAN 30 PY 2009 VL 114 AR C00A04 DI 10.1029/2008JC004892 PG 17 WC Oceanography SC Oceanography GA 401ZM UT WOS:000262983100002 ER PT J AU Judy, DC Qiu, JX Pulskamp, JS Polcawich, G Kaul, R AF Judy, D. C. Qiu, J. X. Pulskamp, J. S. Polcawich, G. Kaul, R. TI Reflection-type continuously-tunable phase shifter using PZT thin-film capacitors SO ELECTRONICS LETTERS LA English DT Article AB The design, fabrication and performance of a re. ection-type tunable phase shifter based on a lead zirconate titanate (PZT) thin-film process is presented. The phase shifter consists of a coplanar wave-guide Lange coupler on high resistivity silicon (HRSi) and two ferroelectric PZT varactors. At 12 GHz, the varactors achieve a capacitance tuning range of 5.5 to 1 along with a phase shift of 86 degrees with bias voltages in the range 0 - 26 V. Analysis of the losses due to the varactors and the rest of the phase shifter is also presented. C1 [Judy, D. C.; Qiu, J. X.; Pulskamp, J. S.; Polcawich, G.; Kaul, R.] USA, Res Lab, Adelphi, MD 20783 USA. RP Judy, DC (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM djudy@arl.army.mil NR 8 TC 2 Z9 2 U1 0 U2 3 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD JAN 29 PY 2009 VL 45 IS 3 BP 171 EP 173 DI 10.1049/el:20093372 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 400ND UT WOS:000262874100025 ER PT J AU He, HY Pandey, R Mallick, G Karna, SP AF He, Haiying Pandey, Ravindra Mallick, Govind Karna, Shashi P. TI Asymmetric Currents in a Donor-Bridge-Acceptor Single Molecule: Revisit of the Aviram-Ratner Diode SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID CURRENT-VOLTAGE CHARACTERISTICS; ELECTRONIC-STRUCTURE; CONDUCTANCE; RECTIFICATION; 1ST-PRINCIPLES; RECTIFIERS; MONOLAYER; DENSITY; WIRES AB The quantum transport via a donor (D)-bridge (B)-acceptor (A) single molecule is studied using density functional theory in conjunction with the Landauer-Buttiker formalism. Asymmetric electrical response for opposite biases is observed resulting in significant rectification in current. The intrinsic dipole moment induced by substituent side groups in the molecule leads to enhanced/reduced polarization of the system under a forward/reverse applied potential, thus asymmetry in the charge distribution and the electronic current under bias. Under a forward bias, the energy gap between the D and A frontier orbitals closes and the current increases rapidly, whereas under a reverse bias, the D-A gap widens and the current remains small. C1 [He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Multiscale Technol Inst, Houghton, MI 49931 USA. [Mallick, Govind; Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu; skarna@arl.army.mil FU DARPA [ARL-DAAD17-03-C-0115] FX The work at Michigan Technological University was performed under support by the DARPA through Contract No. ARL-DAAD17-03-C-0115. The work at Army Research Laboratory was supported by the DARPA MoleApps program and ARL-Director's Research Initiative-FY05-WMR01. Helpful discussions with S. Gowtham, K. C. Lau, and R. Pati are acknowledged. NR 29 TC 21 Z9 21 U1 2 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JAN 29 PY 2009 VL 113 IS 4 BP 1575 EP 1579 DI 10.1021/jp808010a PG 5 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 397MA UT WOS:000262665600060 ER PT J AU Jiang, JY Lima, OV Pei, Y Zeng, XC Tan, L Forsythe, E AF Jiang, Jinyue Lima, Ocelio V. Pei, Yong Zeng, Xiao Cheng Tan, Li Forsythe, Eric TI Dipole-Induced, Thermally Stable Lamellar Structure by Polar Aromatic Silane SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID ALKYLSILOXANES; HYDROLYSIS; MONOLAYERS; PRECURSORS; POLYMERS AB Controlled self-assembly of polar aromatic silane leads to the formation of well-ordered lamellar structures. Graphite-like features are clearly visible with a scanning electron microscope (SEM). In addition, X-ray diffraction (XRD) patterns suggest a d spacing of 14.28 angstrom along the z-axis and 4.42 angstrom in the xy plane, which all agree with theoretical modeling. Constructing multistacks of silane molecules with a high degree of ordering is a daunting task. Amorphous monolayers are frequently reported. Aggravated van der Waals interaction, pi-pi electron overlapping, and solvophobic interactions can all lead the formation of multistacks. The importance of a dipole to the ordered stacking is essentially unknown. This work suggests that a strong dipole-dipole interaction can be another important driving force in forming lamettar structures. The resulting large electrostatic interactions between the dipole and water provide an excellent thermal stability for these lamellas up to 350 degrees C. Organized, layered structures with a permanent dipole can be used in piezoelectric devices or as active surfaces to bind polar molecules, such as toxic gas, methanol, or DNA. C1 [Pei, Yong; Zeng, Xiao Cheng] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA. [Jiang, Jinyue; Lima, Ocelio V.; Tan, Li] Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA. [Jiang, Jinyue; Lima, Ocelio V.; Tan, Li] Univ Nebraska, Nebraska Ctr Mat & Nanosci, Lincoln, NE 68588 USA. [Forsythe, Eric] USA, Res Lab, Flexbile Display Ctr, Adelphi, MD 20783 USA. RP Zeng, XC (reprint author), Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA. EM xzeng1@unl.edu; ltan4@unl.edu; eric.forsythe@us.army.mil RI Pei, Yong/G-1564-2015 FU NSF [CMMI 0825905]; Army Research Office [W911NF-08-1-0190] FX The authors thank Prof. Patrick H. Dussault and his group for their generous help and acknowledge the financial support from the NSF (CMMI 0825905) and the Army Research Office (W911NF-08-1-0190). NR 13 TC 18 Z9 18 U1 0 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JAN 28 PY 2009 VL 131 IS 3 BP 900 EP + DI 10.1021/ja808103h PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA 427PQ UT WOS:000264791600014 PM 19125570 ER PT J AU Huang, LH Xie, J Chu, W Chen, RR Chu, D Hsu, AT AF Huang, Lihong Xie, Jian Chu, Wei Chen, Rongrong Chu, Deryn Hsu, Andrew T. TI Iron-promoted nickel-based catalysts for hydrogen generation via auto-thermal reforming of ethanol SO CATALYSIS COMMUNICATIONS LA English DT Article DE Hydrogen generation; Nickel catalyst; Iron promoter; Auto-thermal reforming; Ethanol ID NI/AL2O3 CATALYSTS; CARBON NANOFIBERS; METAL-CATALYSTS; STEAM; TEMPERATURE; WATER; HYDROTALCITES; OXIDATION; METHANE AB A series of iron-promoted nickel-based catalysts were prepared, and tested in auto-thermal reforming (ATR) of ethanol for hydrogen generation. With iron introduction, mixed crystals of NiAl(2)O(4)-FeAl(2)O(4) spinel phase are formed, which results in modifications in reduction properties and surface electronic properties. The reaction results show a synergic effect of mixed crystals that significantly promotes the catalytic performance: over 10 wt.% iron loading nickel catalyst, conversion of ethanol at 98.43% and selectivity to hydrogen at 108.71% can be achieved at 600 degrees C in ATR of ethanol, which is higher than that of the conventional Ni catalyst (i.e. by 47.44% on hydrogen selectivity). (C) 2008 Elsevier B.V. All rights reserved. C1 [Hsu, Andrew T.] Purdue Univ, Indiana Univ, Purdue Sch Engn & Technol, Indianapolis, IN 46202 USA. [Huang, Lihong; Xie, Jian; Chu, Wei; Chen, Rongrong; Hsu, Andrew T.] Purdue Univ, Indiana Univ, Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Hsu, AT (reprint author), Purdue Univ, Indiana Univ, Purdue Sch Engn & Technol, 799 W Michigan St,ET 215, Indianapolis, IN 46202 USA. EM anhsu@iupui.edu RI Chu, Wei/I-4486-2013; Chu, Wei/C-6140-2011 OI Chu, Wei/0000-0002-7166-5443 FU US Army Research Lab [W911NF-07-2-0036] FX This research work is partially supported by the US Army Research Lab (Grant No. W911NF-07-2-0036). The authors wish to thank Dr. Jeffrey Swope, Department of Geography Science at IU-PUI for XRD test, and to Dr. Dmitry Zemlyanov, Birck Nanotechnology Center of Purdue University for XPS characterizations, and acknowledge the useful discussions provided by Drs. Muhua Chen, Dong Xie, Guigui Wang, Luhua Jiang, and Mr. Michael Reed. NR 26 TC 17 Z9 17 U1 2 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1566-7367 J9 CATAL COMMUN JI Catal. Commun. PD JAN 25 PY 2009 VL 10 IS 5 BP 502 EP 508 DI 10.1016/j.catcom.2008.10.018 PG 7 WC Chemistry, Physical SC Chemistry GA 414LJ UT WOS:000263864900019 ER PT J AU Lennon, C AF Lennon, Craig TI On the Locality of the Prufer Code SO ELECTRONIC JOURNAL OF COMBINATORICS LA English DT Article AB The Prufer code is a bijection between trees on the vertex set [n] and strings on the set [n] of length n 2 (Prufer strings of order n). In this paper we examine the 'locality' properties of the Prufer code, i.e. the effect of changing an element of the Prufer string on the structure of the corresponding tree. Our measure for the distance between two trees T,T* is Delta(T,T*) = n - 1 -vertical bar E(T) boolean AND E(T*)vertical bar. We randomly mutate the mu th element of the Prufer string of the tree T, changing it to the tree T*, and we asymptotically estimate the probability that this results in a change of l edges, i.e. P (Delta = l vertical bar mu) : We find that P (Delta = l vertical bar mu) is on the order of n(-1/3+o(1)) for any integer l > 1; and that P (Delta = 1 vertical bar mu) = (1 - mu/n)(2) + o(1) : This result implies that the probability of a 'perfect' mutation in the Prufer code (one for which Delta(T,T*) - 1) is 1/3 . C1 US Mil Acad, Dept Math, West Point, NY 10996 USA. RP Lennon, C (reprint author), US Mil Acad, Dept Math, 218 Thayer Hall, West Point, NY 10996 USA. EM craigtlennon@gmail.com NR 9 TC 0 Z9 0 U1 0 U2 0 PU ELECTRONIC JOURNAL OF COMBINATORICS PI NEWARK PA C/O FELIX LAZEBNIK, RM 507, EWING HALL, UNIV DELAWARE, DEPT MATHEMATICAL SCIENCES, NEWARK, DE 19716 USA SN 1077-8926 J9 ELECTRON J COMB JI Electron. J. Comb. PD JAN 23 PY 2009 VL 16 IS 1 AR R10 PG 23 WC Mathematics, Applied; Mathematics SC Mathematics GA 397AQ UT WOS:000262634600002 ER PT J AU Anyamba, A Chretien, JP Small, J Tucker, CJ Formenty, PB Richardson, JH Britch, SC Schnabelf, DC Erickson, RL Linthicum, KJ AF Anyamba, Assaf Chretien, Jean-Paul Small, Jennifer Tucker, Compton J. Formenty, Pierre B. Richardson, Jason H. Britch, Seth C. Schnabelf, David C. Erickson, Ralph L. Linthicum, Kenneth J. TI Prediction of a Rift Valley fever outbreak SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE El Nino; Horn of Africa; vegetation index; risk mapping; zoonotic disease ID EL-NINO; ECOLOGICAL CONDITIONS; SOUTHERN OSCILLATION; DOMESTIC-ANIMALS; SATELLITE DATA; KENYA; VIRUS; VEGETATION; AFRICA; EPIDEMICS AB El Nino/Southern Oscillation related climate anomalies were analyzed by using a combination of satellite measurements of elevated sea-surface temperatures and subsequent elevated rainfall and satellite-derived normalized difference vegetation index data. A Rift Valley fever (RVF) risk mapping model using these climate data predicted areas where outbreaks of RVF in humans and animals were expected and occurred in the Horn of Africa from December 2006 to May 2007. The predictions were subsequently confirmed by entomological and epidemiological field investigations of virus activity in the areas identified as at risk. Accurate spatial and temporal predictions of disease activity, as it occurred first in southern Somalia and then through much of Kenya before affecting northern Tanzania, provided a 2 to 6 week period of warning for the Horn of Africa that facilitated disease outbreak response and mitigation activities. To our knowledge, this is the first prospective prediction of a RVF outbreak. C1 [Anyamba, Assaf; Small, Jennifer; Tucker, Compton J.] NASA, Goddard Space Flight Ctr, Biospher Sci Branch, Greenbelt, MD 20771 USA. [Chretien, Jean-Paul; Erickson, Ralph L.] Walter Reed Army Inst Res, Div Prevent Med, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. [Formenty, Pierre B.] WHO, Communicable Dis Cluster Dept Epidem & Pandem Ale, CH-1211 Geneva, Switzerland. [Richardson, Jason H.] USA, Med Res Unit Kenya, Dept Entomol & Vector Borne Dis, APO, AE 09831 USA. [Britch, Seth C.; Linthicum, Kenneth J.] ARS, USDA, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA. [Schnabelf, David C.] USA, Med Res Unit Kenya, APO, AE 09831 USA. RP Anyamba, A (reprint author), NASA, Goddard Space Flight Ctr, Biospher Sci Branch, Code 614-4, Greenbelt, MD 20771 USA. EM asaph.anyamba-1@nasa.gov RI Richardson, Jason/A-9441-2011; Valle, Ruben/A-7512-2013 FU United States Army Medical Research Unit-Kenya; World Health Organization Department of Epidemic and Pandemic Alert and Response; Food and Agricultural Organization of the United Nations; United States Department of Agriculture Foreign Agricultural Service; Centers for Disease Control and Prevention; Department of Defense Global Emerging Infections Surveillance and Response System; United States Department of Agriculture-Agricultural Research Service FX We thank the contributions of the United States Army Medical Research Unit-Kenya, the World Health Organization Department of Epidemic and Pandemic Alert and Response, the Food and Agricultural Organization of the United Nations, The United States Department of Agriculture Foreign Agricultural Service, and the Centers for Disease Control and Prevention. This work and project is supported in part by the Department of Defense Global Emerging Infections Surveillance and Response System and the United States Department of Agriculture-Agricultural Research Service. NR 28 TC 141 Z9 146 U1 6 U2 33 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN 20 PY 2009 VL 106 IS 3 BP 955 EP 959 DI 10.1073/pnas.0806490106 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 399OR UT WOS:000262809700052 PM 19144928 ER PT J AU Sun, PF Fernandez, S Marovich, MA Palmer, DR Celluzzi, CM Boonnak, K Liang, ZD Subramanian, H Porter, KR Sun, W Burgess, TH AF Sun, Peifang Fernandez, Stefan Marovich, Mary A. Palmer, Dupeh R. Celluzzi, Christina M. Boonnak, Kobporn Liang, Zhaodong Subramanian, Hemavathy Porter, Kevin R. Sun, Wellington Burgess, Timothy H. TI Functional characterization of ex vivo blood myeloid and plasmacytoid dendritic cells after infection with dengue virus SO VIROLOGY LA English DT Article DE Dengue virus; Viral infection; Dendritic cell subset; Cytokine; Toll-like receptor ID DOUBLE-STRANDED-RNA; TOLL-LIKE RECEPTOR-3; INTERFERON-PRODUCING CELLS; PROTEIN-KINASE-R; DC-SIGN; ACTIVATION; RECOGNITION; SUBSETS; DISEASE; TLR7 AB Myeloid and plasmacytoid dendritic cells (mDC and pDC) are naturally distinctive subsets. We exposed both subsets to dengue virus (DV) in vitro and investigated their functional characteristics. High levels of DV replication in mDC were found to correlate with DC-SIGN expression. Production of inflammatory cytokines by mDC increased gradually after DV-infection, which was dependent on DV replication. Co-stimulatory markers were upregulated on mDC upon DV-infection. On the contrary, lower levels of DV-replication were observed in pDC, but the cytokine production in pDC was quicker and stronger. This cytokine response was not dependent on viral replication, but dependent on cell endosomal activity and TLR7, and could be also induced by purified DV genome RNA. These results clearly suggested functional differences between mDC and pDC in response to DV infection. Additionally, the TLR7-mediated recognition of DV RNA may be involved in pDC functional activation. (c) 2008 Elsevier Inc. All rights reserved. C1 [Sun, Peifang; Liang, Zhaodong; Subramanian, Hemavathy; Porter, Kevin R.; Burgess, Timothy H.] USN, Med Res Ctr, Silver Spring, MD 20910 USA. [Fernandez, Stefan; Marovich, Mary A.; Palmer, Dupeh R.; Boonnak, Kobporn; Sun, Wellington] Walter Reed Army Inst Res, Silver Spring, MD USA. [Celluzzi, Christina M.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. RP Sun, PF (reprint author), USN, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM sunp@nmrc.navy.mil RI Porter, Kevin/A-8027-2011 NR 39 TC 48 Z9 51 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JAN 20 PY 2009 VL 383 IS 2 BP 207 EP 215 DI 10.1016/j.virol.2008.10.022 PG 9 WC Virology SC Virology GA 396QH UT WOS:000262605700006 PM 19013627 ER PT J AU Bednar, AJ Kirgan, RA Jones, WT AF Bednar, A. J. Kirgan, R. A. Jones, W. T. TI Comparison of standard and reaction cell inductively coupled plasma mass spectrometry in the determination of chromium and selenium species by HPLC-ICP-MS SO ANALYTICA CHIMICA ACTA LA English DT Article DE Chromium; Selenium; Speciation; Reaction cell; Inductively coupled plasma mass spectrometry ID ARSENIC SPECIATION; WATER; CHROMATOGRAPHY; EVOLUTION; REMOVAL; SYSTEM AB Elemental speciation is becoming a common analytical procedure for geochemical investigations. The various redox species of environmentally relevant metals can have vastly different biogeochemical properties, including sorption, solubility, bioavailability, and toxicity. The use of high performance liquid chromatography (HPLC) coupled to elemental specific detectors. such as inductively coupled plasma mass spectrometry (ICP-MS), has become one of the most important speciation methods employed. This is due to the separation versatility of HPLC and the sensitive and selective detection capabilities of ICP-MS. The current study compares standard mode ICP-MS to recently developed reaction cell (RC) ICP-MS, which has the ability to remove or reduce many common polyatomic interferences that can limit the ability of ICP-MS to quantitate certain analytes in complex matrices. Determination of chromium and selenium redox species is achieved using ion-exchange chromatography with elemental detection by standard and RC-ICP-MS, using various chromium and selenium isotopes. In this study, method performance and detection limits for the various permutations of the method (isotope monitored or ICP-MS detection mode) were found to be comparable and generally less than 1 mu g L(-1). The method was tested on synthetic laboratory samples, surface water, groundwater, and municipal tap water matrices. Published by Elsevier B.V. C1 [Bednar, A. J.; Kirgan, R. A.; Jones, W. T.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Bednar, AJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.j.Bednar@erdc.usace.army.mil NR 20 TC 51 Z9 57 U1 5 U2 45 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD JAN 19 PY 2009 VL 632 IS 1 BP 27 EP 34 DI 10.1016/j.aca.2008.10.050 PG 8 WC Chemistry, Analytical SC Chemistry GA 396IN UT WOS:000262585500005 PM 19100879 ER PT J AU De Lucia, FC Gottfried, JL Miziolek, AW AF De Lucia, Frank C., Jr. Gottfried, Jennifer L. Miziolek, Andrzej W. TI Evaluation of femtosecond laser-induced breakdown spectroscopy for explosive residue detection SO OPTICS EXPRESS LA English DT Article ID INDUCED PLASMA SPECTROSCOPY; SPECTROCHEMICAL ANALYSIS; ABLATION; PULSES; NANOSECOND; METALS; SAMPLES; LIBS; CU AB Recently laser-induced breakdown spectroscopy (LIBS) has been investigated as a potential technique for trace explosive detection. Typically LIBS is performed using nanosecond laser pulses. For this work, we have investigated the use of femtosecond laser pulses for explosive residue detection at two different fluences. Femtosecond laser pulses have previously been shown to provide several advantages for laser ablation and other LIBS applications. We have collected LIBS spectra of several bulk explosives and explosive residues at different pulse durations and energies. In contrast to previous femtosecond LIBS spectra of explosives, we have observed atomic emission peaks for the constituent elements of explosives carbon, hydrogen, nitrogen, and oxygen. Preliminary results indicate that several advantages attributed to femtosecond pulses are not realized at higher laser fluences. (C) 2009 Optical Society of America C1 [De Lucia, Frank C., Jr.; Gottfried, Jennifer L.; Miziolek, Andrzej W.] USA, Res Lab, AMSRD, ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. RP De Lucia, FC (reprint author), USA, Res Lab, AMSRD, ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. EM fdelucia@arl.army.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012 NR 28 TC 44 Z9 44 U1 4 U2 18 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JAN 19 PY 2009 VL 17 IS 2 BP 419 EP 425 DI 10.1364/OE.17.000419 PG 7 WC Optics SC Optics GA 408JW UT WOS:000263432300005 PM 19158854 ER PT J AU Yamanaka, T Furukawa, T Matsumoto-Mashimo, C Yamane, K Sugimori, C Nambu, T Mori, N Nishikawa, H Walker, CB Leung, KP Fukushima, H AF Yamanaka, Takeshi Furukawa, Tomoyo Matsumoto-Mashimo, Chiho Yamane, Kazuyoshi Sugimori, Chieko Nambu, Takayuki Mori, Naoki Nishikawa, Hiroyuki Walker, Clay B. Leung, Kai-Poon Fukushima, Hisanori TI Gene expression profile and pathogenicity of biofilm-forming Prevotella intermedia strain 17 SO BMC MICROBIOLOGY LA English DT Article ID PSEUDOMONAS-AERUGINOSA BIOFILMS; FACTOR ALGU SIGMA(E); ESCHERICHIA-COLI; STAPHYLOCOCCUS-EPIDERMIDIS; CHEMICAL-CHARACTERIZATION; CAPNOCYTOPHAGA-OCHRACEA; BACTERIAL BIOFILMS; CLINICAL ISOLATE; CYSTIC-FIBROSIS; COLANIC ACID AB Background: Prevotella intermedia (P. intermedia), a gram-negative, black-pigmented anaerobic rod, has been implicated in the development of chronic oral infection. P. intermedia strain 17 was isolated from a chronic periodontitis lesion in our laboratory and described as a viscous material producing strain. The stock cultures of this strain still maintain the ability to produce large amounts of viscous materials in the spent culture media and form biofilm-like structures. Chemical analyses of this viscous material showed that they were mainly composed of neutral sugars with mannose constituting 83% of the polysaccharides. To examine the biological effect of the extracellular viscous materials, we identified and obtained a naturally-occurring variant strain that lacked the ability to produce viscous materials in vitro from our stock culture collections of strain 17, designated as 17-2. We compared these two strains (strains 17 versus 17-2) in terms of their capacities to form biofilms and to induce abscess formation in mice as an indication of their pathogenicity. Further, gene expression profiles between these two strains in planktonic condition and gene expression patterns of strain 17 in solid and liquid cultures were also compared using microarray assays. Results: Strain 17 induced greater abscess formation in mice as compared to that of the variant. Strain 17, but not 17-2 showed an ability to interfere with the phagocytic activity of human neutrophils. Expression of several genes which including those for heat shock proteins (DnaJ, DnaK, ClpB, GroEL and GroES) were up-regulated two to four-fold with statistical significance in biofilm-forming strain 17 as compared to the variant strain 17-2. Strain 17 in solid culture condition exhibited more than eight-fold up-regulated expression levels of several genes which including those for levanase, extracytoplasmic function-subfamily sigma factor (. E; putative) and polysialic acid transport protein (KpsD), as compared to those of strain 17 in liquid culture media. Conclusion: These results demonstrate that the capacity to form biofilm in P. intermedia contribute to their resistance against host innate defence responses. C1 [Yamanaka, Takeshi; Furukawa, Tomoyo; Matsumoto-Mashimo, Chiho; Yamane, Kazuyoshi; Sugimori, Chieko; Nambu, Takayuki; Mori, Naoki; Nishikawa, Hiroyuki; Fukushima, Hisanori] Osaka Dent Univ, Dept Bacteriol, Osaka, Japan. [Walker, Clay B.] Univ Florida, Coll Dent, Dept Oral Biol, Gainesville, FL 32610 USA. [Leung, Kai-Poon] Walter Reed Army Inst Res, US Army Dent & Trauma Res Detachment, Microbiol Branch, Great Lakes, IL 60088 USA. RP Yamanaka, T (reprint author), Osaka Dent Univ, Dept Bacteriol, Osaka, Japan. EM yamanaka@cc.osaka-dent.ac.jp; tomomo-f@ezweb.ne.jp; mashimo@cc.osaka-dent.ac.jp; yamane@cc.osaka-dent.ac.jp; chieko@cc.osaka-dent.ac.jp; nambu-t@cc.osaka-dent.ac.jp; mori3636@ezweb.ne.jp; nishikawa.dc@kha.biglobe.ne.jp; walkercl@ufl.edu; Kai.Leung@amedd.army.mil; hisanori@cc.osaka-dent.ac.jp FU Osaka Dental University Joint Research Fund [B08-01] FX We would like to acknowledge Mr. Hideaki Hori for his excellent assistance with the electron microscopy. Part of this study was performed at the Institute of Dental Research, Osaka Dental University. This study was supported in part by Osaka Dental University Joint Research Fund (B08-01). NR 61 TC 15 Z9 18 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD JAN 16 PY 2009 VL 9 AR 11 DI 10.1186/1471-2180-9-11 PG 15 WC Microbiology SC Microbiology GA 404TI UT WOS:000263175500001 PM 19146705 ER PT J AU Ellsworth, DL Ellsworth, RE Patney, HL Oviedo, A George, A Croft, DT Love, B Jordan, RM Deyarmin, B Becker, TE Hooke, JA Shriver, CD AF Ellsworth, D. L. Ellsworth, R. E. Patney, H. L. Oviedo, A. George, A. Croft, D. T. Love, B. Jordan, R. M. Deyarmin, B. Becker, T. E. Hooke, J. A. Shriver, C. D. TI Fingerprinting genomic heterogeneity in primary breast carcinomas and among sentinel lymph node metastases: implications for clinical management of breast cancer patients SO CANCER RESEARCH LA English DT Meeting Abstract CT 31st Annual San Antonio Breast Cancer Symposium CY DEC 10-14, 2008 CL San Antonio, TX C1 Windber Res Inst, Windber, PA USA. Henry M Jackson Fdn Advancement Mil Med, Rockville, MD USA. Univ Pittsburgh, Pittsburgh, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Invitrogen, Carlsbad, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JAN 15 PY 2009 VL 69 IS 2 BP 123S EP 123S PG 1 WC Oncology SC Oncology GA 396HQ UT WOS:000262583200191 ER PT J AU Ellsworth, RE Heckman, C Love, B Shriver, CD Henry, M AF Ellsworth, R. E. Heckman, C. Love, B. Shriver, C. D. Henry, M. TI Identification of breast cancer metastasis initiation and virulence genes SO CANCER RESEARCH LA English DT Meeting Abstract CT 31st Annual San Antonio Breast Cancer Symposium CY DEC 10-14, 2008 CL San Antonio, TX C1 Jackson Fdn Med Educ & Res, Windber, PA USA. Windber Res Inst, Windber, PA USA. Invitrogen, Carlsbad, CA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JAN 15 PY 2009 VL 69 IS 2 BP 171S EP 171S PG 1 WC Oncology SC Oncology GA 396HQ UT WOS:000262583200340 ER PT J AU Croft, DT Mao, X Hooke, JA Shriver, CD Shriver, MD Ellsworth, RE AF Croft, D. T. Mao, X. Hooke, J. A. Shriver, C. D. Shriver, M. D. Ellsworth, R. E. TI Admixture mapping to identify breast cancer susceptibility loci in African American women. SO CANCER RESEARCH LA English DT Meeting Abstract CT 31st Annual San Antonio Breast Cancer Symposium CY DEC 10-14, 2008 CL San Antonio, TX C1 Windber Res Inst, Windber, PA USA. Penn State Univ, University Pk, PA 16802 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Henry M Jackson Fdn, Windber, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JAN 15 PY 2009 VL 69 IS 2 BP 184S EP 184S PG 1 WC Oncology SC Oncology GA 396HQ UT WOS:000262583200380 ER PT J AU Field, LA Love, B Kane, J Deyarmin, B Hooke, JA Ellsworth, RE Shriver, CD AF Field, L. A. Love, B. Kane, J. Deyarmin, B. Hooke, J. A. Ellsworth, R. E. Shriver, C. D. TI Role of phosphoserine phosphatase-like in breast disease in African American women. SO CANCER RESEARCH LA English DT Meeting Abstract CT 31st Annual San Antonio Breast Cancer Symposium CY DEC 10-14, 2008 CL San Antonio, TX C1 Windber Res Inst, Windber, PA USA. Invitrogen Informat, Carlsbad, CA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JAN 15 PY 2009 VL 69 IS 2 BP 185S EP 185S PG 1 WC Oncology SC Oncology GA 396HQ UT WOS:000262583200385 ER PT J AU Gotes, JD Benavides, LC Carmichael, MG Hueman, MT Holmes, JP Khoo, S Stojadinovic, A von Hafie, E Ponniah, S Peoples, GE AF Gotes, J. D. Benavides, L. C. Carmichael, M. G. Hueman, M. T. Holmes, J. P. Khoo, S. Stojadinovic, A. von Hafie, E. Ponniah, S. Peoples, G. E. TI Circulating regulatory (CD4(+)CD25(+)FOXP3(+)) T cells decrease in breast cancer patients after vaccination with an Ii-Key-modified class II HER2/neu peptide (AE37) SO CANCER RESEARCH LA English DT Meeting Abstract CT 31st Annual Meeting of the San Antonio Breast Cancer Symposium CY DEC 10-14, 2008 CL San Antonio, TX C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USUHS, Dept Surg, Bethesda, MD USA. USN, San Diego Med Ctr, San Diego, CA 92152 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Antigen Express Inc, Worcester, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JAN 15 PY 2009 VL 69 IS 2 SU S BP 242S EP 242S PG 1 WC Oncology SC Oncology GA 396HQ UT WOS:000262583201152 ER PT J AU Benavides, LC Gates, JD Holmes, JP Mittendorf, EA Ponniah, S Peoples, GE AF Benavides, L. C. Gates, J. D. Holmes, J. P. Mittendorf, E. A. Ponniah, S. Peoples, G. E. TI Optimal method of dosing HER2/neu peptide vaccines: US Military Cancer Institute Clinical Trials Group Study 1-01, 1-02, 1-03, and 1-04 SO CANCER RESEARCH LA English DT Meeting Abstract CT 31st Annual San Antonio Breast Cancer Symposium CY DEC 10-14, 2008 CL San Antonio, TX C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USN, Med Ctr, San Diego, CA 92152 USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. USUHS, Dept Surg, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JAN 15 PY 2009 VL 69 IS 2 BP 244S EP 244S PG 1 WC Oncology SC Oncology GA 396HQ UT WOS:000262583201157 ER PT J AU Holmes, JP Benavides, LC Gatav, JD Mittendorf, EA Ponniah, S Peoples, GE AF Holmes, J. P. Benavides, L. C. Gatav, J. D. Mittendorf, E. A. Ponniah, S. Peoples, G. E. TI Incidence of hormone-receptor negative and basal type breast tumors among HLA-A2(+) patients and possible implications for cancer vaccine trials: US Military Cancer Institute clinical trials group study I-01, I-02, I-03, and I-04 SO CANCER RESEARCH LA English DT Meeting Abstract CT 31st Annual Meeting of the San Antonio Breast Cancer Symposium CY DEC 10-14, 2008 CL San Antonio, TX C1 USN, Med Ctr, San Diego, CA 92152 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. UTMD Anderson Canc Ctr, Houston, TX USA. USUHS, Dept Surg, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JAN 15 PY 2009 VL 69 IS 2 SU S BP 248S EP 249S PG 2 WC Oncology SC Oncology GA 396HQ UT WOS:000262583201171 ER PT J AU Stout Gergich, NL Levy, E Springer, B Pfalzer, L McGarvey, C Gerber, L Soballe, P AF Stout Gergich, N. L. Levy, E. Springer, B. Pfalzer, L. McGarvey, C. Gerber, L. Soballe, P. TI Pre operative assessment enables the early detection and treatment of shoulder impairments related to breast cancer treatment. SO CANCER RESEARCH LA English DT Meeting Abstract CT 31st Annual San Antonio Breast Cancer Symposium CY DEC 10-14, 2008 CL San Antonio, TX C1 Natl Naval Med Ctr, Bethesda, MD USA. NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Michigan, Flint, MI 48503 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JAN 15 PY 2009 VL 69 IS 2 BP 277S EP 277S PG 1 WC Oncology SC Oncology GA 396HQ UT WOS:000262583201260 ER PT J AU Ellsworth, DL Gillard, D Love, B Ellsworth, RE Deyarmin, B Hooke, JA Kostyniak, PJ Shriver, CD AF Ellsworth, D. L. Gillard, D. Love, B. Ellsworth, R. E. Deyarmin, B. Hooke, J. A. Kostyniak, P. J. Shriver, C. D. TI Abundance and distribution of polychlorinated biphenyls (PCBs) in breast tissue SO CANCER RESEARCH LA English DT Meeting Abstract CT 31st Annual San Antonio Breast Cancer Symposium CY DEC 10-14, 2008 CL San Antonio, TX C1 Windber Res Inst, Windber, PA USA. SUNY Buffalo, Buffalo, NY 14260 USA. Invitrogen, Carlsbad, CA USA. Henry M Jackson Fdn, Rockville, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JAN 15 PY 2009 VL 69 IS 2 BP 312S EP 313S PG 2 WC Oncology SC Oncology GA 396HQ UT WOS:000262583201365 ER PT J AU Pan, YL Pinnick, RG Hill, SC Chang, RK AF Pan, Yang-Le Pinnick, Ronald G. Hill, Steven C. Chang, Richard K. TI Particle-Fluorescence Spectrometer for Real-Time Single-Particle Measurements of Atmospheric Organic Carbon and Biological Aerosol SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MASS-SPECTROMETRY; INTRINSIC FLUORESCENCE; BIOAEROSOLS; SPECTRA; LASER; SIZE; CLASSIFICATION; INSTRUMENT; DESIGN AB A particle-fluorescence spectrometer (PFS) for real-time measurements of single-particle UV-laser-induced fluorescence (UV-LIF) excited with a pulsed (263-nm) laser is reported. The dispersed UV-LIF spectra are measured by a 32-anode PMT detector with spectral coverage from 280-600 nm. The PFS represents a significant improvement over our previous apparatus [Pinnick et al. Atmos. Environ. 2004 38 1657] and can (1) measure fluorescence spectra of bacterial particles having light-scattering sizes as small as 1 mu m (previously limited to about 3 mu m) and so can measure particles with size in the range of 1-10 mu m, (2) measure each particle's elastic scattering which can be used to estimate particle size (not (3) measure single-particle fluorescence available previously), spectra with a laser and detector that can record spectra as fast as 90,000/s, although the highest rates we have found experimentally in atmospheric measurements is only several per second (previously limited by detectors to only 25/s) and (4) provide a time stamp a data block of spectra, with time resolution from 10 ms to 10 min. In addition, the PFS has been modified to be more robust, transportable, and smaller. The use of an aerodynamic-focusing sheath inlet nozzle assembly has improved the sample rate. The PFS has been employed to measure UV-LIF spectra from individual atmospheric particles during October-December 2006 and January-May 2008 in New Haven, CT, and during January-May 2007 in Las Cruces, NM. C1 [Pan, Yang-Le; Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. [Pinnick, Ronald G.; Hill, Steven C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Pan, YL (reprint author), Yale Univ, Dept Appl Phys, 15 Prospect St, New Haven, CT 06520 USA. EM yongle.pan@yale.edu FU Physical Science and Technology Basic Research Program and by the Army Research Laboratory FX We acknowledge support by the Defense Threat Reduction Agency under the Physical Science and Technology Basic Research Program and by the Army Research Laboratory. We thank Professor Menachem Elimelech (Yale) for providing laboratory space with a window that enabled us to make the atmospheric aerosol measurements. John Bowersett (ARL machinist) made the double-nozzle (clean-air sheath) assembly for the PFS. NR 25 TC 28 Z9 28 U1 2 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 15 PY 2009 VL 43 IS 2 BP 429 EP 434 DI 10.1021/es801544y PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 394FG UT WOS:000262430700034 PM 19238975 ER PT J AU Neumann, TA Albert, MR Engel, C Courville, Z Perron, F AF Neumann, Thomas A. Albert, Mary R. Engel, Chandler Courville, Zoe Perron, Frank TI Sublimation rate and the mass-transfer coefficient for snow sublimation SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article DE Sublimation; Snow; Mass transfer; Mass-transfer coefficient ID VAPOR TRANSPORT; BLOWING SNOW; ICE-SHEET; SURFACE; FIRN; RESPECT; STATION; BALANCE; SCALE; AIR AB Sublimation of snow is a fundamental process that affects the crystal structure of snow, and is important for ice core interpretation, remote sensing, snow hydrology and chemical processes in snow. Prior investigations have inferred the sublimation rate from energy, isotopic, or mass-balance calculations using field data. Consequently, these studies were unable to control many of the environmental parameters which determine sublimation rate (e.g. temperature, relative humidity, snow microstructure). We present Sublimation rate measurements on snow samples in the laboratory, where we have controlled many of these parameters simultaneously. Results show that the air stream exiting the snow sample is typically saturated under a wide range of sample temperature and air-flow rate, within measurement precision. This result Supports theoretical work on single ice grains which found that there is no energy barrier to be overcome during sublimation, and suggests that snow sublimation is limited by vapor diffusion into pore spaces, rather than sublimation at crystal faces. Undersaturation may be possible in large pore spaces (i.e. surface- or depth-hoar layers) with relatively high air-flow rates. We use these data to place bounds on the mass-transfer coefficient for snow as a linear function of Reynolds number, and find that h(m) = 0.566 Re + 0.075. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Neumann, Thomas A.; Engel, Chandler] Univ Vermont, Dept Geol, Burlington, VT 05405 USA. [Albert, Mary R.; Courville, Zoe; Perron, Frank] US Army Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Engel, Chandler] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. RP Neumann, TA (reprint author), Univ Vermont, Dept Geol, Burlington, VT 05405 USA. EM Thomas.Neumann@uvm.edu RI Neumann, Thomas/D-5264-2012; OI Albert, Mary/0000-0001-7842-2359 FU NSF-OPP [0338008, 0337304] FX This work was supported by NSF-OPP 0338008 to T. Neumann and NSF-OPP 0337304 to M. Albert. We thank E.J. Steig, J.S. WettlaLlfer and E.D. Waddington for helpful discussions, and an anonymous reviewer for suggestions that have improved the content and clarity of the manuscript. NR 20 TC 15 Z9 16 U1 4 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0017-9310 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD JAN 15 PY 2009 VL 52 IS 1-2 BP 309 EP 315 DI 10.1016/j.ijheatmasstransfer.2008.06.003 PG 7 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA 390ZV UT WOS:000262203100033 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Dmitry Shkuratov, Yuriy Videen, Gorden TI Light scattering by a finite cylinder containing a spherical cavity using Sh-matrices SO OPTICS COMMUNICATIONS LA English DT Article ID PARTICLES; CAPSULE AB We use the Sh-matrix formalism that contains the shape-dependent parameters of the T-matrix to derive an analytical solution for the light scattering from a finite cylinder containing a spherical cavity. The integral expressions for the Sh-matrix elements are simpler than those of the T-matrix elements and the case of a sphere embedded in a finite cylinder these integrals can be solved analytically. Published by Elsevier B.V. C1 [Videen, Gorden] USA, Res Lab, AMSRD ARL CI EM, Adelphi, MD 20783 USA. [Petrov, Dmitry; Shkuratov, Yuriy] Kharkov Natl Univ, Astron Inst Kharkov, UA-61022 Kharkov, Ukraine. RP Videen, G (reprint author), USA, Res Lab, AMSRD ARL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM petrov@astron.kharkov.ua; gvideen@arl.army.mil NR 16 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JAN 15 PY 2009 VL 282 IS 2 BP 156 EP 166 DI 10.1016/j.optcom.2008.09.060 PG 11 WC Optics SC Optics GA 385ZP UT WOS:000261852400003 ER PT J AU Thomas, SJ Hombach, J Barrett, A AF Thomas, Stephen J. Hombach, Joachim Barrett, Alan TI Scientific consultation on cell mediated immunity (CMI) in dengue and dengue vaccine development SO VACCINE LA English DT Review DE Dengue; Vaccine; CMI ID T-LYMPHOCYTE RESPONSES; HUMAN DENDRITIC CELLS; ORIGINAL ANTIGENIC SIN; ANTIBODY-DEPENDENT ENHANCEMENT; VIRUS TYPE-1 INFECTION; HEMORRHAGIC-FEVER; VIRAL LOAD; PERIPHERAL-BLOOD; YELLOW-FEVER; HIV TYPE-1 AB Dengue is a re-emerging arboviral disease of great public health importance. Limited understanding of protective immune responses against dengue has hampered advancement of dengue vaccine candidates. Demonstrating an immunological correlate of protection has been limited to associating quantitative neutralizing antibody titers with clinical outcomes following infection. There have been a number of studies investigating the role of cell mediated immunity (CMI) in natural infections and these have demonstrated roles in both virus clearance and potentiating disease. Vaccine developers have extended the exploratory study of CMI in natural infection to the study of dengue vaccine recipients. Primary infections and rnonovalent vaccine administration generates dengue type-specific T-cell responses. Secondary infection, vaccination of flavivirus primed individuals, or administration of multivalent vaccine candidates results in broad, cross-reactive T-cell responses, similar to the broadening of antibody patterns. However, the precise function of CMI in protection or disease pathology remains ill-defined and, at present, there is no evidence to suggest that CMI can be utilized as a correlate of protection. Nonetheless, the study of CMI in natural infection and following vaccine administration should continue in an attempt to improve the understanding of dengue immunopathology, vaccine candidate immunogenicity, and potential correlates of protection. Published by Elsevier Ltd. C1 [Thomas, Stephen J.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Hombach, Joachim] WHO, Initiat Vaccine Res, CH-1211 Geneva, Switzerland. [Barrett, Alan] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX USA. [Barrett, Alan] Univ Texas Med Branch, Dept Pathol, Galveston, TX USA. RP Thomas, SJ (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM Stephen.thomas@afrims.org FU Bill & Melinda Gates Foundation FX The financial support from the Bill & Melinda Gates Foundation is kindly acknowledged. NR 110 TC 24 Z9 24 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 14 PY 2009 VL 27 IS 3 BP 355 EP 368 DI 10.1016/j.vaccine.2008.10.086 PG 14 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 399DJ UT WOS:000262780300005 PM 19022321 ER PT J AU Lederman, E Miramontes, R Openshaw, J Olson, VA Karem, KL Marcinak, J Panares, R Staggs, W Allen, D Weber, SG Vora, S Gerber, SI Hughes, CM Regnery, R Collins, L Diaz, PS Reynolds, MG Damon, I AF Lederman, Edith Miramontes, Roque Openshaw, John Olson, Victoria A. Karem, Kevin L. Marcinak, John Panares, Rodrigo Staggs, Wayne Allen, Donna Weber, Stephen G. Vora, Surabhi Gerber, Susan I. Hughes, Christine M. Regnery, Russell Collins, Limone Diaz, Pamela S. Reynolds, Mary G. Damon, Inger TI Eczema vaccinatum resulting from the transmission of vaccinia virus from a smallpox vaccinee: An investigation of potential fomites in the home environment SO VACCINE LA English DT Article DE Smallpox vaccination; Vaccinia virus; Eczema vaccinatum; Environmental sampling ID MONKEYPOX-VIRUS; INFECTION; IMMUNITY; ORTHOPOXVIRUS; EFFICACY; CONTACT AB On March 3, 2007, a 2-year-old boy was hospitalized with eczema vaccinatum. His two siblings, one with eczema, were subsequently removed from the home. Swabs of household items obtained on March 13th were analyzed for orthopoxvirus DNA signatures with real-time PCR. Virus Culture was attempted on positive specimens. Eight of 25 household samples were positive by PCR for orthopoxvirus; of these, three yielded viable vaccinia virus in culture. Both siblings were found to have serologic evidence of orthopoxvirus exposure. These findings have implications for smallpox preparedness, especially in situations where some household members are not candidates for vaccination. Published by Elsevier Ltd. C1 [Lederman, Edith; Olson, Victoria A.; Karem, Kevin L.; Hughes, Christine M.; Regnery, Russell; Reynolds, Mary G.; Damon, Inger] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Poxvirus & Rabies Branch, Atlanta, GA USA. [Lederman, Edith; Miramontes, Roque; Openshaw, John] Ctr Dis Control & Prevent, Off Workforce & Dev, Atlanta, GA USA. [Miramontes, Roque; Diaz, Pamela S.] Ctr Dis Control & Prevent, Div Bioterrorism Preparedness & Response, Epidemiol Surveillance & Response Branch, Atlanta, GA USA. [Panares, Rodrigo] Hammond City Hlth Dept, Hammond, IN USA. [Staggs, Wayne; Allen, Donna] Indiana State Dept Hlth, Indianapolis, IN 46202 USA. [Weber, Stephen G.] Univ Chicago, Infect Dis Sect, Dept Internal Med, Chicago, IL 60637 USA. [Gerber, Susan I.] Chicago Dept Publ Hlth, Chicago, IL USA. [Collins, Limone] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Washington, DC 20307 USA. RP Lederman, E (reprint author), USN, Med Ctr, Div Infect Dis, 34800 Bob Wilson Dr, San Diego, CA 92134 USA. EM edith.lederman@med.navy.mil OI Miramontes, Roque/0000-0001-9535-460X NR 24 TC 13 Z9 14 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 14 PY 2009 VL 27 IS 3 BP 375 EP 377 DI 10.1016/j.vaccine.2008.11.019 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 399DJ UT WOS:000262780300007 PM 19027813 ER PT J AU Martini, WZ AF Martini, Wenjun Zhou TI Fibrinogen metabolic responses to trauma SO SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE LA English DT Review ID FRESH-FROZEN PLASMA; LIFE-THREATENING COAGULOPATHY; REQUIRING MASSIVE TRANSFUSION; OTHERWISE FATAL HEMORRHAGE; WHOLE-BLOOD TRANSFUSION; HYPOTHERMIC COAGULOPATHY; DILUTIONAL COAGULOPATHY; FLUID RESUSCITATION; LACTATED RINGERS; COAGULATION AB Coagulation complications are significant contributors to morbidity and mortality in trauma patients. Although the lethal triad of hypothermia, acidosis and coagulopathy has been recognized for over a decade, the underlying mechanisms related to the development of coagulopathy remain unclear. Recent data suggest that decreased fibrinogen levels contribute to the development of coagulation disorders. Thus, regulation of fibrinogen availability, not fully understood at present, may play an important role in survival of trauma patients. This review summarizes the recent findings of the studies that have explored mechanisms related to changes in fibrinogen availability following trauma-related events. Trauma alters fibrinogen metabolism in a variety of ways: hemorrhage-accelerated fibrinogen breakdown; hypothermia-inhibited fibrinogen synthesis; and, acidosis-accelerated fibrinogen breakdown. However, hemorrhage, hypothermia andcidosis all result in a consistent outcome of fibrinogen availability deficit, supporting the notion of fibrinogen supplementation in trauma patients with coagulation defects. Future prospective clinical trials are needed to confirm the beneficial effects of fibrinogen supplementation in trauma patients with bleeding complications. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM wenjun.martini@amedd.army.mil FU US Army Medical Research and Medical Command FX This work was supported by the US Army Medical Research and Medical Command. NR 74 TC 20 Z9 21 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1757-7241 J9 SCAND J TRAUMA RESUS JI Scand. J. Trauma Resusc. Emerg. Med. PD JAN 13 PY 2009 VL 17 AR 2 DI 10.1186/1757-7241-17-2 PG 6 WC Emergency Medicine SC Emergency Medicine GA 661OL UT WOS:000282737500001 PM 19144127 ER PT J AU Onorato, M Osborne, AR Janssen, PAEM Resio, D AF Onorato, M. Osborne, A. R. Janssen, P. A. E. M. Resio, D. TI Four-wave resonant interactions in the classical quadratic Boussinesq equations SO JOURNAL OF FLUID MECHANICS LA English DT Article ID SURFACE GRAVITY-WAVES; ENERGY-TRANSFER; SPECTRA AB We investigate theoretically the irreversibile energy transfer in flat bottom shallow water waves. Starting from the oldest weakly nonlinear dispersive wave model in shallow water, i.e. the original quadratic Boussinesq equations, and by developing a statistical theory (kinetic equation) of the aforementioned equations, we show that the four-wave resonant interactions are naturally part of the shallow water wave dynamics. These interactions are responsible for a constant flux of energy in the wave spectrum, i.e. an energy cascade towards high wavenumbers, leading to a power law in the wave spectrum or the form of k(-3/4). The nonlinear time scale of the interaction is found to be of the order of (h/a)(4) wave periods, with a the wave amplitude and h the water depth. We also compare the kinetic equation arising from the Boussinesq equations with the arbitrary-depth Hasselmann equation and show that, in the limit of shallow water, the two equations coincide. It is found that in the narrow band case, both in one-dimensional propagation and in the weakly two-dimensional case, there is no irreversible energy transfer because the coupling coefficient in the kinetic equation turns out to be identically zero on the resonant manifold. C1 [Onorato, M.; Osborne, A. R.] Univ Turin, Dipartimento Fis Gen, I-10125 Turin, Italy. [Janssen, P. A. E. M.] ECMWF, Reading, Berks, England. [Resio, D.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Onorato, M (reprint author), Univ Turin, Dipartimento Fis Gen, Via Pietro Giuria 1, I-10125 Turin, Italy. EM onorato@ph.unito.it RI Onorato, Miguel/G-7104-2012 OI Onorato, Miguel/0000-0001-9141-2147 NR 22 TC 9 Z9 9 U1 1 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD JAN 10 PY 2009 VL 618 BP 263 EP 277 DI 10.1017/S0022112008004229 PG 15 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA 398ON UT WOS:000262741500012 ER PT J AU Byrd, EFC Rice, BM AF Byrd, Edward F. C. Rice, Betsy M. TI A Comparison of Methods To Predict Solid Phase Heats of Formation of Molecular Energetic Salts SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID LATTICE ENERGIES; ACCURATE THERMOCHEMISTRY; ELECTROSTATIC POTENTIALS; BOND SEPARATION; DENSITY; THERMODYNAMICS; GAUSSIAN-3; VOLUMES; PACKING AB In this study a variety of methods were used to compute the energies for lattice enthalpies and gas phase heats of formation of the ionic constituents used in Born-Fajans-Haber cycles to produce solid phase heats of formation of molecular ionic energetic crystals. Several quantum mechanically based or empirical approaches to calculate either the heat of formation of the ionic constituents in the gas phase (Delta H(f(g))(degrees)) or the lattice enthalpy were evaluated. Solid phase heats of formation calculated from combinations of Delta H(f(g))(degrees) and Delta H(Lattice)(degrees) determined through various approaches are compared with experimental values for a series of molecular energetic salts with 1: 1, 2:1 and 2:2 charge ratios. Recommendations for combinations of Delta H(f(g))(degrees) and Delta H(Lattice)(degrees) to produce best agreement with experiment are given, along with suggestions for improvements. of the methods. C1 [Byrd, Edward F. C.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Byrd, EFC (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. FU Office of Naval Research; Environmental Quality Technology Ordnance Program FX This work was partially supported by the Office of Naval Research and the Environmental Quality Technology Ordnance Program. All calculations were performed at either the ARL or ASC Major Shared Resource Centers of the Department of Defense High Performance Computing Modernization Program. NR 32 TC 24 Z9 24 U1 2 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD JAN 8 PY 2009 VL 113 IS 1 BP 345 EP 352 DI 10.1021/jp807822e PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 390BU UT WOS:000262140100044 PM 19086797 ER PT J AU Clayton, JD AF Clayton, J. D. TI A continuum description of nonlinear elasticity, slip and twinning, with application to sapphire SO PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES LA English DT Article DE crystal plasticity; twinning; alumina ID SINGLE-CRYSTALS; SHOCK-WAVE; BASAL SLIP; PLASTIC DEFORMATION; ALPHA-AL2O3; DISLOCATIONS; DENSITY; THERMODYNAMICS; COMPRESSION; SIMULATION AB A model is developed for elasticity, plasticity and twinning in anisotropic single crystals subjected to large deformations. Dislocation glide and deformation twinning are dissipative, while energy storage mechanisms associated with dislocation lines and twin boundaries are described via scalar internal state variables. Concepts from continuum crystal plasticity are invoked, with shearing rates on discrete glide and twinning systems modelled explicitly. The model describes aspects of thermomechanical behaviour of single crystals of alumina over a range of loading conditions. Resolved shear stresses necessary for glide or twin nucleation at low to moderate temperatures are estimated from nonlinear elastic calculations, theoretical considerations of Peierls barriers and stacking fault energies and observations from shock physics experiments. These estimates are combined with the existing data from high-temperature experiments to provide initial yield conditions spanning a wide range of temperatures. The model reflects hardening of glide and twin systems from dislocations accumulated during basal slip. Residual elastic volume changes, predicted from nonlinear elastic considerations and approximated dislocation line energies, are positive and proportional to the dislocation line density. While the model suggests that generation of very large dislocation densities could influence the pressure volume response, volume increases from defects are predicted to be small in crystals deformed via basal glide on a single system. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil RI Clayton, John/C-7760-2009 NR 60 TC 44 Z9 46 U1 0 U2 9 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 1364-5021 J9 P R SOC A JI Proc. R. Soc. A-Math. Phys. Eng. Sci. PD JAN 8 PY 2009 VL 465 IS 2101 BP 307 EP 334 DI 10.1098/rspa.2008.0281 PG 28 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 375YU UT WOS:000261150500018 ER PT J AU Guwatudde, D Wabwire-Mangen, F Eller, LA Eller, M McCutchan, F Kibuuka, H Millard, M Sewankambo, N Serwadda, D Michael, N Robb, M AF Guwatudde, David Wabwire-Mangen, Fred Eller, Leigh Anne Eller, Michael McCutchan, Francine Kibuuka, Hannah Millard, Monica Sewankambo, Nelson Serwadda, David Michael, Nelson Robb, Merlin CA Kayunga Cohort Res Team TI Relatively Low HIV Infection Rates in Rural Uganda, but with High Potential for a Rise: A Cohort Study in Kayunga District, Uganda SO PLOS ONE LA English DT Article AB Background: Few studies have been conducted in Uganda to identify and quantify the determinants of HIV-1 infection. We report results from a community-based cohort study, whose primary objectives were to determine HIV-1 prevalence, incidence, and determinants of these infections, among other objectives. Methodology: Consenting volunteers from the rural district of Kayunga in Uganda aged 15-49 years were enrolled between March and July 2006. Participants were evaluated every six months. A questionnaire that collected information on behavioral and other HIV-1 risk factors was administered, and a blood sample obtained for laboratory analysis at each study visit. Principal Findings: HIV-1 prevalence among the 2025 participants was 9.9% (95% CI = 8.6%-11.2%). By the end of 12 months of follow-up, 1689.7 person-years had been accumulated, with a median follow-up time of 11.97 months. Thirteen HIV-1 incident cases were detected giving an annual HIV-1 incidence of 0.77% (95% CI = 0.35-1.19). Prevalence of HSV-2 infection was 57% and was strongly associated with prevalent HIV-1 infection (adjusted Odds Ratio = 3.9, 95% CI = 2.50-6.17); as well as incident HIV-1 infection (adjusted Rate Ratio (RR) = 8.7, 95% CI = 1.11-67.2). The single most important behavioral characteristic associated with incident HIV infection was the number of times in the past 6 months, a participant had sex with person(s) they suspected/knew were having sex with others; attaining statistical significance at 10 times and higher (adjusted RR = 6.3, 95% CI = 1.73-23.1). By the end of 12 months of follow-up, 259 participants (13%) were lost to follow-up, 13 (0.6%) had died, and 2 (0.1%) had withdrawn consent. Conclusions: Despite relatively low HIV-1 incidence observed in this community, prevalence remains relatively high. In the presence of high prevalence of HSV-2 infection and the behavioral characteristic of having sex with more than one partner, there is potential for increase in HIV-1 incidence. C1 [Guwatudde, David; Eller, Leigh Anne; Eller, Michael; Kibuuka, Hannah; Millard, Monica] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Guwatudde, David; Wabwire-Mangen, Fred; Serwadda, David] Makerere Univ, Sch Publ Hlth, Kampala, Uganda. [Eller, Leigh Anne; Eller, Michael; McCutchan, Francine; Robb, Merlin] Henry M Jackson Fdn, Rockville, MD USA. [Sewankambo, Nelson] Makerere Univ, Sch Med, Kampala, Uganda. [Michael, Nelson] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. RP Guwatudde, D (reprint author), Makerere Univ, Walter Reed Project, Kampala, Uganda. EM dguwatudde@muwrp.org OI Sewankambo, Nelson/0000-0001-9362-053X FU U.S. Army Medical Research and Material Command [W81XWH-04-02-0005]; Henry M. Jackson Foundation for the Advancement of Military Medicine [1Y-A1-26-42-07]; DAIDS [1Y-A1-26-42-07] FX This study was supported by the U.S. Army Medical Research and Material Command and its cooperative agreement (W81XWH-04-02-0005) with the Henry M. Jackson Foundation for the Advancement of Military Medicine and by an interagency agreement (1Y-A1-26-42-07) with DAIDS. The funders of this study had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 37 TC 19 Z9 19 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 7 PY 2009 VL 4 IS 1 AR e4145 DI 10.1371/journal.pone.0004145 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 437FX UT WOS:000265473300010 PM 19127290 ER PT J AU Pati, RK Lee, IC Gaskell, KJ Ehrman, SH AF Pati, Ranjan K. Lee, Ivan C. Gaskell, Karen J. Ehrman, Sheryl H. TI Precipitation of Nanocrystalline CeO2 Using Triethanolamine SO LANGMUIR LA English DT Article ID CERIUM(IV) OXIDE; POWDERS; CEO2-TIO2; CATALYSTS; ALCOHOL; CERIA AB Synthesis of cerium oxide nanocrystallites via precipitation using triethanolamine is reported. The molecular water associated with the cerium nitrate precursor is exploited to generate hydroxyl ions with the help of triethanolamine, facilitating precipitation. The small crystallite diameter (3 nm) in the as prepared powder is believed to result from the limited amount of water present. Solvent type has no effect on the final crystallite size or structure; however, it plays an important role in the dispersion of the nanoparticles with dispersity of the particles increasing with increasing carbon chain length of the solvent alcohol used. C1 [Ehrman, Sheryl H.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. RP Ehrman, SH (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM sehrman@umd.edu RI Lee, Ivan/H-6444-2011; Gaskell, Karen/H-8270-2014 FU U.S. Army Research Laboratory [W911QX-04-C-0105]; National Science Foundation [DMR-0080008]; Maryland NanoCenter and its NispLab; National Science Foundation; MRSEC Shared Experimental Facility FX The authors would like to thank Kirtland Linegar for assistance with DLS measurements and Peter Zavalij for assistance with X-ray diffraction. This work was partially supported by U.S. Army Research Laboratory, Contract Number: W911QX-04-C-0105. Support from the National Science Foundation. under Grant No. DMR-0080008 for the purchase of the X-ray photoelectron spectrometer is acknowledged. Support of the Maryland NanoCenter and its NispLab is also acknowledged. The NispLab is supported in part by the National Science Foundation as a MRSEC Shared Experimental Facility. NR 27 TC 18 Z9 21 U1 1 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD JAN 6 PY 2009 VL 25 IS 1 BP 67 EP 70 DI 10.1021/la8031286 PG 4 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 390PQ UT WOS:000262176600018 PM 19061314 ER PT J AU Wang, GG Weng, YM Chu, D Xie, D Chen, RR AF Wang, Guigui Weng, Yiming Chu, Deryn Xie, Dong Chen, Rongrong TI Preparation of alkaline anion exchange membranes based on functional poly(ether-imide) polymers for potential fuel cell applications SO JOURNAL OF MEMBRANE SCIENCE LA English DT Article DE Poly(ether-imide); Alkaline anion exchange membrane; Ionic conductivity ID IONIC-CONDUCTIVITY AB A novel poly(ether-imide)-based alkaline anion exchange membrane with no free base has been prepared and characterized for its ionic conductivity in water, which is a critical metric of its applicability in a liquid-fed direct methanol fuel cell. The poly(ether-imide)-based membranes were prepared by chloromethylation, quaternization and alkalization of commercial poly(ether-imide) and the derivatives were characterized by NMR. The chemical and thermal stabilities were investigated by measuring changes of ionic conductivities when the membranes were placed in various alkaline concentrations and temperatures for 24 h. The membranes were stable at all concentrations of KOH at room temperature, but not at elevated temperatures. The membranes were stable in 1.0M KOH solution up to 80 degrees C without losing membrane integrity. The measured conductivity of the formed membrane ranged from 2.28 to 3.51 X 10(-3) S/cm at room temperature. This preliminary study indicates that functionalized poly(etherimide) has suitable conductivity suggesting that it can be used as an alkaline anion exchange membrane in fuel cell applications. (C) 2008 Elsevier B.V. All rights reserved. C1 [Wang, Guigui; Weng, Yiming; Xie, Dong; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, 799 W Michigan St,ET 209E, Indianapolis, IN 46202 USA. EM rochen@iupui.edu FU US Army Research Laboratory [W911NF-07-2-0036] FX This work was sponsored by the US Army Research Laboratory (W911NF-07-2-0036) and the Richard G. Lugar Center for Renewable Energy at Indiana University - Purdue University, Indianapolis. NR 15 TC 178 Z9 181 U1 2 U2 69 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0376-7388 J9 J MEMBRANE SCI JI J. Membr. Sci. PD JAN 5 PY 2009 VL 326 IS 1 BP 4 EP 8 DI 10.1016/j.memsci.2008.09.037 PG 5 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA 386TY UT WOS:000261906700003 ER PT J AU Crum-Cianflone, N Hullsiek, KH Marconi, V Weintrob, A Ganesan, A Barthel, RV Fraser, S Agan, BK Wegner, S AF Crum-Cianflone, Nancy Hullsiek, Katherine Huppler Marconi, Vincent Weintrob, Amy Ganesan, Anuradha Barthel, R. Vincent Fraser, Susan Agan, Brian K. Wegner, Scott TI Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study SO AIDS LA English DT Article DE cancer; epidemiology; HAART; HIV; malignancy; military ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; NONMELANOMA SKIN-CANCER; AIDS-DEFINING CANCERS; NON-HODGKINS-LYMPHOMA; HUMAN-PAPILLOMAVIRUS; KAPOSIS-SARCOMA; ERA; INDIVIDUALS; ADULTS; RISK AB Objective: To describe trends in incidence rates of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) during the HIV epidemic and to evaluate predictors, including the impact of antiretroviral therapy, of cancer development. Design: Retrospective analysis of a multicenter, prospective natural history study including 4498 HIV-infected US military beneficiaries with 33486 person-years of follow-up. Methods: Predictors evaluated included demographics, clinical data, time-updated CD4 cell counts, HIV viral loads, and antiretroviral history. Time periods were classified as early pre (1984-1990), late pre (1991 - 1995), early post (1996-2000), and late post (2001 - 2006) HAART eras. Cox proportional hazard models were used to evaluate the association of specific factors with cancer. Results: Ten percent of HIV-infected persons developed cancer. ADC rates increased between the early and late pre-HAART eras (7.6 and 14.2 cases per 1000 person-years) and have since declined from 5.4 to 2.7 in the early and late HAART eras, respectively (P < 0.001). Rates of NADCs have risen over the four periods (2.9, 2.8, 4.2, 6.7, P=0.0004). During the late HAART era, 71%, of cancers were NADCs. Predictors for ADCs included low CD4 cell count, noncancer AIDS diagnosis, and lack of HAART. NADCs were predicted by increasing age and white race (clue to skin cancers). Conclusion: Although the rate of ADCs continues to fall, the rate of NADCs is rising and now accounts for the majority of cancers in HIV-infected persons. The development of NADCs is associated with increasing age among HIV patients. HAART use is protective for ADCs, but did not significantly impact NADCs. (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [Crum-Cianflone, Nancy] USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy; Hullsiek, Katherine Huppler; Marconi, Vincent; Weintrob, Amy; Ganesan, Anuradha; Barthel, R. Vincent; Fraser, Susan; Agan, Brian K.; Wegner, Scott] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, TriServ AIDS Clin Consortium, Bethesda, MD 20814 USA. [Hullsiek, Katherine Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Marconi, Vincent; Agan, Brian K.] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Barthel, R. Vincent] USN, Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, Hants, England. [Fraser, Susan] Tripler Army Med Ctr, Infect Dis Clin, Honolulu, HI 96859 USA. RP Crum-Cianflone, N (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU NIAID NIH HHS [HU0001-05-2-0011]; PHS HHS [HU0001-05-2-0011] NR 39 TC 131 Z9 132 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD JAN 2 PY 2009 VL 23 IS 1 BP 41 EP 50 DI 10.1097/QAD.0b013e328317cc2d PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 390XS UT WOS:000262197600007 PM 19050385 ER PT S AU Dai, TH Tegos, GP Lu, ZS Zhiyentayev, T Huang, LY Franklin, MJ Baer, DG Hamblin, MR AF Dai, Tianhong Tegos, George P. Lu, Zongshun Zhiyentayev, Timur Huang, Liyi Franklin, Michael J. Baer, David G. Hamblin, Michael R. BE Kessel, DH TI Antimicrobial photodynamic therapy in a mouse model of Acinetobacter baumannii burn infection SO 12TH WORLD CONGRESS OF THE INTERNATIONAL PHOTODYNAMIC ASSOCIATION: PHOTODYNAMIC THERAPY: BACK TO THE FUTURE SE Proceedings of SPIE LA English DT Proceedings Paper CT 12th World Congress of the International-Photodynamic-Association (IPA) on Photodynamic Therapy - Back to the Future CY JUN 11-15, 2009 CL Seattle, WA SP Int Photodynam Assoc (IPA), SPIE, AF Off Sci Res, Axcan Pharma Inc, Covidien Imaging Solut, Ondine Biopharma Corp, Photocure ASA, QinetiQ N Amer, Wellman Ctr PhotoMed, Wayne State Univ DE Antimicrobial photodynamic therapy; photosensitizer; mouse model; Acinetobacter baumannii; infection ID GRAM-NEGATIVE BACTERIA; PSEUDOMONAS-AERUGINOSA; MICE; TRANSLOCATION; WOUNDS AB Multi-drug resistant Acinetobacter baumanii infections represent a growing problem, especially in traumatic wounds and burns suffered by military personnel injured in Middle Eastern conflicts. Effective treatment using traditional antibiotics can be extremely difficult and new antimicrobial approaches are being investigated. One of these antimicrobial alternatives could be the combination of non-toxic photosensitizers (PS) and visible light known as photodynamic therapy (PDT). We report on the establishment of a new mouse model of full thickness thermal burns infected with a bioluminescent derivative of a clinical Iraqi isolate of A. baumannii and its PDT treatment by topical application of a PS produced by covalent conjugation chlorin(e6) to polyethylenimine followed by illumination of the burn surface with red light. Application of 10 8 A. baumannii cells to the surface of 10-second burns made on the dorsal surface of shaved female BALB/c mice led to chronic infections that lasted on average 22 days characterized by a remarkably stable bacterial bioluminescence. PDT carried out on day 0 soon after applying bacteria gave over three logs of loss of bacterial luminescence in a light exposure dependent manner, while PDT carried out on day 1 and day 2 gave approximately a 1.7-log reduction. Application of PS dissolved in 10% or 20% DMSO without light gave only modest reduction in bacterial luminescence from mouse burns. Some bacterial regrowth in the treated burn was observed but was generally modest. It was also found that PDT did not lead to inhibition of wound healing. The data suggest that PDT may be an effective new treatment for multi-drug resistant localized A. baumannii infections. C1 [Dai, Tianhong; Tegos, George P.; Lu, Zongshun; Zhiyentayev, Timur; Huang, Liyi; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Dai, Tianhong; Tegos, George P.; Huang, Liyi; Hamblin, Michael R.] Harvard Med Sch, Dept Dermatol, Boston, MA USA. [Lu, Zongshun] Tianjin Med Univ Gen Hosp, Dept Gastroenterol, Tianjin, Peoples R China. [Zhiyentayev, Timur] M Lomonosov Moscow State Univ, Dept Chem, Moscow, Russia. [Huang, Liyi] Guangxi Med Univ, Dept Infect Dis, First Affiliated Coll Hosp, Nanning, Peoples R China. [Franklin, Michael J.] Montana State Univ, Dept Microbiol, Bozeman, MT USA. [Baer, David G.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Hamblin, Michael R.] Harvard Div Hlth Sci & Technol, Cambridge, MA USA. RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. OI Hamblin, Michael/0000-0001-6431-4605 FU US Air Force MFEL [FA9550-04-1-0079]; NIH [AI050875] FX This work was supported by the US Air Force MFEL program (contract FA9550-04-1-0079) and the NIH (grant AI050875).. We are grateful to Victoria Hamrahi for assistance with bacterial identification and to Christopher H. Contag, Tayyaba Hasan, Albert T. McManus for helpful advice and discussion. NR 24 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7660-9 J9 PROC SPIE PY 2009 VL 7380 AR 738037 DI 10.1117/12.823065 PG 9 WC Optics; Radiology, Nuclear Medicine & Medical Imaging SC Optics; Radiology, Nuclear Medicine & Medical Imaging GA BDM00 UT WOS:000313709100049 ER PT B AU Tahmoush, D Silvious, J AF Tahmoush, Dave Silvious, Jerry BE DawsonHowe, K Dahyot, R Kokaram, A Lacey, G TI Radar Stride Rate Extraction SO 2009 13TH INTERNATIONAL MACHINE VISION AND IMAGE PROCESSING CONFERENCE LA English DT Proceedings Paper CT 13th International Machine Vision and Image Processing Conference CY SEP 02-04, 2009 CL Trinity Coll Dublin, Dublin, IRELAND HO Trinity Coll Dublin ID HUMAN GAIT; DOPPLER; MODEL AB We seek to understand the extraction of radar signals generated by human motion and extract information from them. We demonstrate the extraction of information associated with gait, especially the stride rate, from radar data. We describe algorithms used for detection, the radar sensors used for the measurements, and detail some of the features that can be extracted. We make measurements of human subjects in outdoor clutter backgrounds for identification. These features can serve as identifying information in a scene with multiple subjects. We gather ground truth using video and accelerometers to validate the radar data. C1 [Tahmoush, Dave; Silvious, Jerry] USA, Res Lab, Washington, DC USA. RP Tahmoush, D (reprint author), USA, Res Lab, Washington, DC USA. EM david.tahmoush@us.army.mil NR 25 TC 3 Z9 3 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-4875-3 PY 2009 BP 128 EP 133 DI 10.1109/IMVIP.2009.30 PG 6 WC Computer Science, Artificial Intelligence; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BPD49 UT WOS:000278570100023 ER PT B AU Xu, GS Shi, YQ Su, W AF Xu, Guanshuo Shi, Yun Qing Su, Wei GP IEEE TI CAMERA BRAND AND MODEL IDENTIFICATION USING MOMENTS OF 1-D AND 2-D CHARACTERISTIC FUNCTIONS SO 2009 16TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, VOLS 1-6 LA English DT Proceedings Paper CT 16th IEEE International Conference on Image Processing CY NOV 07-10, 2009 CL Cairo, EGYPT SP IEEE DE Moments of Characteristic Functions; Camera Identification AB Camera brand and model identification has become one important task of image forensics. Most of the research on this topic focuses on only one or two parts of camera inner structure. In this paper, we propose a universal image statistical model which takes the whole image formation pipeline of cameras into consideration. By examining their comprehensive effects on the formulated images, our assumption is that any difference of the parts of the image formation pipeline can result in the statistical difference of the output image. Moments of 1-D characteristic functions generated from the given image, its JPEG 2-D array, their prediction-error 2-D arrays, and all of their three-level wavelet subbands, and moments of 2-D characteristic functions generated only from JPEG 2-D array accordingly are used to build the statistical model for classification. Our experimental works have verified the effectiveness of this proposed method. C1 [Xu, Guanshuo; Shi, Yun Qing] New Jersey Inst Technol, Newark, NJ 07102 USA. [Su, Wei] US Army, CERDEC, Ft Monmouth, NJ 07703 USA. RP Xu, GS (reprint author), New Jersey Inst Technol, Newark, NJ 07102 USA. EM gx3@njit.edu; shi@njit.edu; Wei.Su@us.army.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5653-6 PY 2009 BP 2917 EP + PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BQA01 UT WOS:000280464301177 ER PT B AU Peng, HH Rao, R AF Peng, Honghong Rao, Raghuveer GP IEEE TI HYPERSPECTRAL IMAGE ENHANCEMENT WITH VECTOR BILATERAL FILTERING SO 2009 16TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING, VOLS 1-6 LA English DT Proceedings Paper CT 16th IEEE International Conference on Image Processing CY NOV 07-10, 2009 CL Cairo, EGYPT SP IEEE DE Hyperspectral imaging; Bilateral filtering; Remote sensing AB An approach is proposed to extend bilateral filtering to the vector case so as to simultaneously take spectral and spatial information into account by using spectral distances and multivariate Gaussian functions. To simplify the determination of the parameters of the corresponding covariance matrix, the data vectors are transformed to eigenspace through principal component analysis (PCA). By locally adapting to the spectral distribution in decorrelated PCA space, the proposed approach offers effective noise removal while keeping the spatial details in the band images. It also provides dynamic range enhancement of severely affected bands to make meaningful data extraction possible. Experimental results with the proposed approach using remote-sensed hyperspectral data demonstrate improved denoising and enhancement in comparison to existing methods. C1 [Peng, Honghong] Rochester Inst Technol, Ctr Imaging Sci, 54 Lomb Mem Dr, Rochester, NY 14623 USA. [Rao, Raghuveer] AMSRD, ARL SE SE, Army Res Lab, Adelphi, MD 20783 USA. RP Peng, HH (reprint author), Rochester Inst Technol, Ctr Imaging Sci, 54 Lomb Mem Dr, Rochester, NY 14623 USA. EM hxp4595@rit.edu; raghuveer.rao@us.army.mil NR 9 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5653-6 PY 2009 BP 3713 EP + DI 10.1109/ICIP.2009.5414250 PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BQA01 UT WOS:000280464301374 ER PT B AU Mitasova, H Hardin, E Overton, M Harmon, RS AF Mitasova, Helena Hardin, Eric Overton, Margery Harmon, Russell S. BE Di, L Chen, A TI New spatial measures of terrain dynamics derived from time series of lidar data SO 2009 17TH INTERNATIONAL CONFERENCE ON GEOINFORMATICS, VOLS 1 AND 2 LA English DT Proceedings Paper CT 17th International Conference on Geoinformatics CY AUG 12-14, 2009 CL George Mason Univ, Fairfax, VA HO George Mason Univ ID NORTH-CAROLINA AB We anticipate that multiyear lidar surveys, currently focused on vulnerable coastal areas, will soon become a common resource for monitoring and analysis of various aspects of regional terrain change. We propose raster based measures for mapping and quantification of discrete and continuous terrain changes by introducing novel concepts, such as core and envelope surfaces, contour evolution band, and evolution regression slope map that can provide insights into the spatial aspects of terrain dynamics and changes in structures. The methodology is applied to a section of North Carolina coast where multiyear time series of lidar data is already available. Dynamics of bare dune and beach systems, changes in structures and vegetation growth are mapped and quantified to evaluate the proposed approach. C1 [Mitasova, Helena; Hardin, Eric; Overton, Margery] North Carolina State Univ, Dept Marine Earth & Atmospher Sci & Phys, Raleigh, NC 27695 USA. [Overton, Margery] North Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Harmon, Russell S.] US Army, Res Lab, Army Res Off, Environm Sci Div, Durham, NC 27703 USA. RP Mitasova, H (reprint author), North Carolina State Univ, Dept Marine Earth & Atmospher Sci & Phys, Raleigh, NC 27695 USA. EM hmitaso@unity.ncsu.edu; ejhardin@ncsu.edu; overton@ncsu.edu; russell.harmon@us.army.mil FU North Carolina Sea; u.S. Army Research Office FX North Carolina Sea Grant and u.S. Army Research Office support for this research is gratefully acknowledge NR 13 TC 1 Z9 1 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-4562-2 PY 2009 BP 363 EP + PG 2 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Remote Sensing SC Computer Science; Engineering; Remote Sensing GA BOU28 UT WOS:000277622400070 ER PT B AU Rogers, JP Barbara, D Domeniconi, C AF Rogers, James P. Barbara, Daniel Domeniconi, Carlotta BE Di, L Chen, A TI Detecting Spatio-Temporal Outliers with Kernels and Statistical Testing SO 2009 17TH INTERNATIONAL CONFERENCE ON GEOINFORMATICS, VOLS 1 AND 2 LA English DT Proceedings Paper CT 17th International Conference on Geoinformatics CY AUG 12-14, 2009 CL George Mason Univ, Fairfax, VA HO George Mason Univ AB Outlier detection is the discovery of points that are exceptional when compared with a set of observations that are considered normal. Such points are important since they often lead to the discovery of exceptional events. In spatio-temporal data, observations are vectors of feature values, tagged with a geographical location and a timestamp. A spatio-temporal outlier is an observation whose attribute values are significantly different from those of other spatially and temporally referenced objects in a spatio-temporal neighborhood. It represents an object that is significantly different from its neighbors, even though it may not be significantly different from the entire population. The discovery of outliers in spatio-temporal data is then complicated by the fact that one needs to focus the search on appropriate spatio-temporal neighborhoods of points. The work in this paper leverages an algorithm, StrOUD (Strangeness-based Outlier Detection algorithm), that has been developed and used by the authors to detect outliers in various scenarios (including vector spaces and non-vectorial data). StrOUD uses a measure of strangeness to categorize an observation, and compares the strangeness of a point with the distribution of strangeness of a set of baseline observations (which are assumed to be mostly from normal points). Using statistical testing, StrOUD determines if the point is an outlier or not. The technique described in this paper defines strangeness as the sum of distances to nearest neighbors, where the distance between two observations is computed as a weighted combination of the distance between their vectors of features, their geographical distance, and their temporal distance. Using this multi-modal distance measure (thereby called kernel), our technique is able to diagnose outliers with respect to spatio-temporal neighborhoods. We show how our approach is capable of determining outliers in real-life data, including crime data, and a set of observations collected by buoys in the Gulf of Mexico during the 2005 hurricane season. We show that the use of different weightings on the kernel distances allows the user to adapt the size of spatio-temporal neighborhoods. C1 [Rogers, James P.] USA, Engn Res & Dev Ctr, 7701 Telegraph Rd, Alexandria, VA 22315 USA. [Barbara, Daniel; Domeniconi, Carlotta] George Mason Univ, Dept CS, MSN 4A5, Fairfax, VA 22030 USA. RP Rogers, JP (reprint author), USA, Engn Res & Dev Ctr, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM James.P.Rogers.II@erdc.usace.army.mil; dbarbara@gmu.edu; carlotta@cs.gmu.edu NR 11 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-4562-2 PY 2009 BP 639 EP + PG 2 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Remote Sensing SC Computer Science; Engineering; Remote Sensing GA BOU28 UT WOS:000277622400123 ER PT S AU Zhang, QC Burk, A Husna, F Callanan, R Agarwal, A Palmour, J Stahlbush, R Scozzie, C AF Zhang, Qingchun (Jon) Burk, Al Husna, Fatima Callanan, Robert Agarwal, Anant Palmour, John Stahlbush, Robert Scozzie, Charles GP IEEE TI 4H-SiC Bipolar Junction Transistors: From Research to Development - A Case Study: 1200 V, 20 A, Stable SiC BJTs with High Blocking Yield SO 2009 21ST INTERNATIONAL SYMPOSIUM ON POWER SEMICONDUCTOR DEVICES & ICS SE Proceedings of the International Symposium on Power Semiconductor Devices & ICs LA English DT Proceedings Paper CT 21st International Symposium on Power Semiconductor Devices & ICs CY JUN 14-18, 2009 CL Barcelona, SPAIN SP IEEE Electron Devices Soc, IEEE Power Elect Soc, IEEJ, CSIC, Ctr Nacl Microelect, IMB, Gen Catalunya, Minist Ciencia & Innovac AB In this paper, for the first time, large area SiC BJTs were fabricated on SiC wafers with reduced Basal Plane Dislocations (BPDs). We have demonstrated: (1) stable performance on 1200 V, 20 A SiC BJTs after long duration of electrical stress at 2 different current densities up to 150 A/cm(2); (2) a blocking yield of >80% with low leakage current (<20 nA at 1800 V) on 3 '' wafers along with current gains in a range of 35-40. Both breakthroughs highlight the possibility for SiC BJTs to be commercialized and utilized in power electronics. C1 [Zhang, Qingchun (Jon); Burk, Al; Husna, Fatima; Callanan, Robert; Agarwal, Anant; Palmour, John] Cree Inc, 3026 E Cornwallis Rd, Res Triangle Pk, NC 27709 USA. [Stahlbush, Robert] US Navy, Res Lab, Washington, DC 20375 USA. [Scozzie, Charles] US Army, Res Lab, Adelphi, MD 20783 USA. RP Zhang, QC (reprint author), Cree Inc, 3026 E Cornwallis Rd, Res Triangle Pk, NC 27709 USA. EM Jon_Zhang@cree.com FU Army Research Laboratory, Adelphi, Maryland FX The authors would like to acknowledge the funding support from Army Research Laboratory, Adelphi, Maryland. The authors are grateful to Dr. Peter Muzykov and Prof. T. S. Sudarshan at University of South Carolina for EBIC measurements. NR 6 TC 12 Z9 12 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1063-6854 BN 978-1-4244-3525-8 J9 PROC INT SYMP POWER PY 2009 BP 339 EP + PG 2 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BNP83 UT WOS:000275190100086 ER PT B AU Li, DP Calvert, P Mello, C AF Li, Dapeng Calvert, Paul Mello, Charlene GP IEEE TI Inkjet printing virus-based sensors SO 2009 35TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE LA English DT Proceedings Paper CT 35th Annual Northeast Bioengineering Conference CY APR 03-05, 2009 CL Cambridge, MA ID IMMOBILIZED MAGNETOELASTIC SENSOR; FLUORESCENT-BACTERIOPHAGE ASSAY; ESCHERICHIA-COLI O157-H7; SALMONELLA-TYPHIMURIUM; PHAGE; MILK AB Bacteriophages are viruses that infect bacteria. They are highly specific for bacteria; moreover, one phage can only infect a subgroup of strains within the same bacterial species. Therefore, bacteriophage attached to a surface offers a promising method to detect specific bacterial pathogens in an air or water environment. We envision a pattern of such phage-sensing spots or lines printed onto a surface to provide sensitivity to multiple organisms and multi-sensor reliability. To realize such an application several key technical challenges must first be overcome. The phage must be attached or printed on a surface such that it remains able to interact with and infect the bacteria. After infection there must be a system for growing the bacteria and amplifying the phage without losing the integrity of the pattern. This article discusses the potential of inkjet printed viruses as sensors for bacterial detection and shows our initial efforts in exploring the immobilization of M 13 as a model virus on various substrates via inkjet printing and examining the infectivity of viruses to E. coli cells after the immobilization. Virus lines are inkjet printed on glass, textiles and gels with immobilization via chemical bonding or a soft polymer overlayer. Agrose top overlay assays were preformed to evaluate the infectivity of immobilized M 13 viruses. C1 [Li, Dapeng; Calvert, Paul] Univ Massachusetts Dartmouth, Dept Mat & Text, 285 Old Westport Rd, N Dartmouth, MA 02747 USA. [Mello, Charlene] US Army, Natick Res Dev & Engn Ctr, Biosci & Technol Team, Natick, MA 01760 USA. RP Li, DP (reprint author), Univ Massachusetts Dartmouth, Dept Mat & Text, 285 Old Westport Rd, N Dartmouth, MA 02747 USA. NR 18 TC 0 Z9 0 U1 1 U2 10 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-4362-8 PY 2009 BP 244 EP + PG 2 WC Engineering, Biomedical SC Engineering GA BKP77 UT WOS:000268886300120 ER PT B AU Zaghloul, AI Anthony, TK AF Zaghloul, Amir I. Anthony, Theodore K. GP IEEE TI A 76-GHz Antenna with Highly-Tapered Aperture for Collision Avoidance Systems SO 2009 3RD EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION, VOLS 1-6 LA English DT Proceedings Paper CT 3rd European Conference on Antennas and Propagation CY MAR 23-27, 2009 CL Berlin, GERMANY AB Vehicle-mounted radar systems for collision avoidance require receive antennas with scanned narrow beams in azimuth and a broad beam in elevation. This paper presents a pyramidal horn array of 32 elements, designed at 76 GHz with a 40-dB Taylor aperture distribution. A tightly spaced waveguide power divider provides the tapered distribution with adjusted waveguide lengths between the different stages in order to achieve the uniform phase in all paths. The last stage of the power divider uses equal power splits because of space limitations, which results in slightly higher side-lobes and low-level grating lobes. The fabricated array shows results that match the HFSS-simulated results. C1 [Zaghloul, Amir I.; Anthony, Theodore K.] USA, Res Lab, Adelphi, MD USA. RP Zaghloul, AI (reprint author), USA, Res Lab, Adelphi, MD USA. EM amir.zaghloul@arl.army.mil; tanthony@arl.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-4753-4 PY 2009 BP 472 EP 476 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BOF99 UT WOS:000276522100112 ER PT B AU Keller, SD Coburn, WO Weiss, SJ AF Keller, Steven D. Coburn, William O. Weiss, Steven J. GP IEEE TI Efficient Electromagnetic Modeling of Bent Monopole Antenna on Aircraft Wing Using FEKO SO 2009 3RD EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION, VOLS 1-6 LA English DT Proceedings Paper CT 3rd European Conference on Antennas and Propagation CY MAR 23-27, 2009 CL Berlin, GERMANY AB A VHF bent monopole antenna mounted on an Army UAV wing platform is modeled and simulated using the FEKO electromagnetic simulation software package and the results are compared with measured radiation pattern data. In order to reduce the complexity of the final FEKO simulation and minimize its runtime and memory usage, the simplification of the composite wing structure as a PEC wing is verified through measurement and comparison of a foil-wrapped wing platform vs. a bare composite wing platform. The results of this comparison indicate that a PEC model of the wing platform is an appropriate approximation of the composite wing structure and should yield radiation patterns discrepancies less than 2.6 dB. Using a PEC wing model, the FEKO simulation results correspond well with the measured data for the azimuth-plane radiation pattern, with < 2.5 dB difference for the majority of the data. C1 [Keller, Steven D.; Coburn, William O.; Weiss, Steven J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Keller, SD (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM steven.keller4@us.army.mil; keefe.coburn@us.army.mil; steven.weiss@us.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-4753-4 PY 2009 BP 2141 EP 2143 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BOF99 UT WOS:000276522101052 ER PT B AU Weiss, S AF Weiss, Steven GP IEEE TI A Vector Transform for use in Solving Electromagnetic Problems in Cartesian Coordinates SO 2009 3RD EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION, VOLS 1-6 LA English DT Proceedings Paper CT 3rd European Conference on Antennas and Propagation CY MAR 23-27, 2009 CL Berlin, GERMANY AB This document develops the formulation of a vector transform in Cartesian coordinates - originally conceived by Chew and Habashy in 1986 [1]. This transform is ideally organized for realizing Green's functions in layered media. Such Green's functions are fundamental to the analytical setup of many problems that may then be solved by the method of moments. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Weiss, S (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM sweiss@arl.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-4753-4 PY 2009 BP 2409 EP 2412 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BOF99 UT WOS:000276522101116 ER PT J AU Kozick, RJ Sadler, BM AF Kozick, Richard J. Sadler, Brian M. GP IEEE TI Accuracy of Source Localization Based on Squared-Range Least Squares (SR-LS) Criterion SO 2009 3RD IEEE INTERNATIONAL WORKSHOP ON COMPUTATIONAL ADVANCES IN MULTI-SENSOR ADAPTIVE PROCESSING (CAMSAP) LA English DT Proceedings Paper CT 3rd IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing (CAMSAP) CY DEC 13-16, 2009 CL Aruba, NETHERLANDS SP IEEE, IEEE Signal Proc Soc ID LOCATION AB An estimator for source localization from range measurements was recently proposed by Beck, Stoica, and Li. The method is based on minimizing a least squares criterion for the squared-ranges (SR-LS), and a key advantage is that the global minimum of the SR-LS criterion can be computed efficiently. If the range measurements are modeled with additive, Gaussian noise, then the maximum likelihood (ML) estimator minimizes the LS criterion based on the ranges (R-LS). However, no computationally efficient algorithm is currently known for finding the global minimum of R-LS, so it is useful to study the sensitivity of SR-LS to additive noise. We compare the asymptotic (large sample) accuracy of source location estimates based on the R-LS and SR-LS criteria to study the robustness of SR-LS to additive noise on the range measurements. The asymptotic covariance of SR-LS is equal to or greater than R-LS, and we provide compact matrix expressions for the difference. The covariance expressions are analyzed to gain insight regarding sensor geometries for which SR-LS is more sensitive to noise than R-LS. The case of three sensors is analyzed completely, and while sensor configurations exist for which the difference is unbounded, we show that these are peculiar limiting cases and that the difference is bounded in cases of practical interest. C1 [Kozick, Richard J.] Bucknell Univ, Lewisburg, PA 17837 USA. [Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Kozick, RJ (reprint author), Bucknell Univ, Lewisburg, PA 17837 USA. NR 8 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5180-7 PY 2009 BP 37 EP 40 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BYI50 UT WOS:000298924200010 ER PT J AU Ravindra, VC Bar-Shalom, Y Damarla, T AF Ravindra, Vishal Cholapadi Bar-Shalom, Yaakov Damarla, Thyagaraju GP IEEE TI Feature-Aided Localization and Tracking of Ground Vehicles Using Passive Acoustic Sensor Networks SO 2009 3RD IEEE INTERNATIONAL WORKSHOP ON COMPUTATIONAL ADVANCES IN MULTI-SENSOR ADAPTIVE PROCESSING (CAMSAP) LA English DT Proceedings Paper CT 3rd IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing (CAMSAP) CY DEC 13-16, 2009 CL Aruba, NETHERLANDS SP IEEE, IEEE Signal Proc Soc AB Tracking of a moving ground target using acoustic signals obtained from a passive sensor network is a difficult problem as the signals are contaminated by wind noise and are hampered by road conditions, terrain and multipath, etc., and are not deterministic. Multiple target tracking becomes even more challenging, especially when some of the vehicles are light (wheeled) and some are heavy (e. g., tracked vehicles like tanks). In such cases the stronger acoustic signals from the heavy vehicles can mask those from the light vehicles, leading to poor detection of such targets. Acoustic passive sensor arrays obtain direction of arrival (DoA) angle estimates of such emitters from the received signals. The full position estimates of targets, obtained following the association of the DoA angle estimates from least three sensor arrays, are used for target tracking. However, because of the particular challenges encountered in multiple ground vehicle tracking, this association is not always reliable and thus, target tracking using such full position measurements only is difficult and it can lead to lost tracks. In this paper we propose a new feature-aided tracking (FAT) algorithm to augment the existing target tracking algorithms which use only kinematic measurements, in order to improve the tracking performance. We present a novel DoA detection technique followed by frequency domain feature extraction from real data. The techniques are developed based on real data sets and tested on real data based on a field experiment. C1 [Ravindra, Vishal Cholapadi; Bar-Shalom, Yaakov] Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA. [Damarla, Thyagaraju] Army Res Lab, Adelphi, MD 20783 USA. RP Ravindra, VC (reprint author), Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA. EM vcr@engr.uconn.edu; ybs@engr.uconn.edu; rdamarla@arl.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5180-7 PY 2009 BP 241 EP 244 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BYI50 UT WOS:000298924200061 ER PT B AU Kozick, RJ Sadler, BM AF Kozick, Richard J. Sadler, Brian M. GP IEEE TI Accuracy of Source Localization Based on Squared-Range Least Squares (SR-LS) Criterion SO 2009 3RD IEEE INTERNATIONAL WORKSHOP ON COMPUTATIONAL ADVANCES IN MULTI-SENSOR ADAPTIVE PROCESSING (CAMSAP 2009) LA English DT Proceedings Paper CT 3rd IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing (CAMSAP) CY DEC 13-16, 2009 CL Aruba, NETHERLANDS SP IEEE, IEEE Signal Proc Soc ID LOCATION AB An estimator for source localization from range measurements was recently proposed by Beck, Stoica, and Li. The method is based on minimizing a least squares criterion for the squared-ranges (SR-LS), and a key advantage is that the global minimum of the SR-LS criterion can be computed efficiently. If the range measurements are modeled with additive, Gaussian noise, then the maximum likelihood (ML) estimator minimizes the LS criterion based on the ranges (R-LS). However, no computationally efficient algorithm is currently known for finding the global minimum of R-LS, so it is useful to study the sensitivity of SR-LS to additive noise. We compare the asymptotic (large sample) accuracy of source location estimates based on the R-LS and SR-LS criteria to study the robustness of SR-LS to additive noise on the range measurements. The asymptotic covariance of SR-LS is equal to or greater than R-LS, and we provide compact matrix expressions for the difference. The covariance expressions are analyzed to gain insight regarding sensor geometries for which SR-LS is more sensitive to noise than R-LS. The case of three sensors is analyzed completely, and while sensor configurations exist for which the difference is unbounded, we show that these are peculiar limiting cases and that the difference is bounded in cases of practical interest. C1 [Kozick, Richard J.] Bucknell Univ, Lewisburg, PA 17837 USA. [Sadler, Brian M.] US Army Res Lab, Washington, DC USA. RP Kozick, RJ (reprint author), Bucknell Univ, Lewisburg, PA 17837 USA. NR 7 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5179-1 PY 2009 BP 37 EP + PG 2 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BUK97 UT WOS:000289697600010 ER PT B AU Ravindra, VC Bar-Shalom, Y Damarla, T AF Ravindra, Vishal Cholapadi Bar-Shalom, Yaakov Damarla, Thyagaraju GP IEEE TI Feature-Aided Localization and Tracking of Ground Vehicles Using Passive Acoustic Sensor Networks SO 2009 3RD IEEE INTERNATIONAL WORKSHOP ON COMPUTATIONAL ADVANCES IN MULTI-SENSOR ADAPTIVE PROCESSING (CAMSAP 2009) LA English DT Proceedings Paper CT 3rd IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing (CAMSAP) CY DEC 13-16, 2009 CL Aruba, NETHERLANDS SP IEEE, IEEE Signal Proc Soc AB Tracking of a moving ground target using acoustic signals obtained from a passive sensor network is a difficult problem as the signals are contaminated by wind noise and are hampered by road conditions, terrain and multipath, etc., and are not deterministic. Multiple target tracking becomes even more challenging, especially when some of the vehicles are light (wheeled) and some are heavy (e.g., tracked vehicles like tanks). In such cases the stronger acoustic signals from the heavy vehicles can mask those from the light vehicles, leading to poor detection of such targets. Acoustic passive sensor arrays obtain direction of arrival (DoA) angle estimates of such emitters from the received signals. The full position estimates of targets, obtained following the association of the DoA angle estimates from least three sensor arrays, are used for target tracking. However, because of the particular challenges encountered in multiple ground vehicle tracking, this association is not always reliable and thus, target tracking using such full position measurements only is difficult and it can lead to lost tracks. In this paper we propose a new feature-aided tracking (FAT) algorithm to augment the existing target tracking algorithms which use only kinematic measurements, in order to improve the tracking performance. We present a novel DoA detection technique followed by frequency domain feature extraction from real data. The techniques are developed based on real data sets and tested on real data based on a field experiment. C1 [Ravindra, Vishal Cholapadi; Bar-Shalom, Yaakov] Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA. [Damarla, Thyagaraju] US Army Res Lab, Adelphi, MD 20783 USA. RP Ravindra, VC (reprint author), Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA. EM vcr@engr.uconn.edu; ybs@engr.uconn.edu; rdamarla@arl.army.mil RI Ravindra, Vishal/C-7967-2012 NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5179-1 PY 2009 BP 241 EP + PG 2 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BUK97 UT WOS:000289697600061 ER PT B AU Benson, K Marvel, LM AF Benson, Karyn Marvel, Lisa M. GP IEEE TI Using Adaptive Lossless Compression to Characterize Network Traffic SO 2009 43RD ANNUAL CONFERENCE ON INFORMATION SCIENCES AND SYSTEMS, VOLS 1 AND 2 LA English DT Proceedings Paper CT 43rd Annual Conference on Information Sciences and Systems CY MAR 18-20, 2009 CL Baltimore, MD SP Johns Hopkins Univ, Dept Elect & Comp Engn, IEEE Informat Theory Soc AB Detecting anomalies in network traffic is a challenging task, not only because of the inherent difficulty of identifying anomalies such as intrusions [1] but also because of the sheer volume of data. In this paper, we attempt to extend existing work in the field of steganalysis to the problem of detecting anomalies in network traffic. By losslessly compressing network traffic using an adaptive compression algorithm, we postulate that it is possible to characterize normal network traffic. Once typical traffic has been defined, it is possible to identify anomalous traffic as the traffic that does not compress well. C1 [Benson, Karyn; Marvel, Lisa M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Benson, K (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM karyn.benson@arl.army.mil; marvel@arl.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-2733-8 PY 2009 BP 276 EP 277 DI 10.1109/CISS.2009.5054730 PG 2 WC Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BLT78 UT WOS:000270992700053 ER PT B AU Blum, RS Xu, ZM Sadler, BM AF Blum, Rick S. Xu, Zhemin Sadler, Brian M. GP IEEE TI Decentralized Sensor Selection Based on Sensor Observations for Energy Efficient Hypothesis Testing SO 2009 43RD ANNUAL CONFERENCE ON INFORMATION SCIENCES AND SYSTEMS, VOLS 1 AND 2 LA English DT Proceedings Paper CT 43rd Annual Conference on Information Sciences and Systems CY MAR 18-20, 2009 CL Baltimore, MD SP Johns Hopkins Univ, Dept Elect & Comp Engn, IEEE Informat Theory Soc ID NETWORKS AB We consider the sensor selection problem in a wireless sensor network attempting to solve a binary hypothesis testing problem. The selection is based only on the sensor observations and the focus is on the extreme case where the position of the sensors is not exploited except through its influence on the sensor observations. Decentralized processing approaches are desired. A subset of sensors are selected to transmit their observations to a fusion center where the hypothesis testing decision will be made. We propose three new sensor selection schemes based on observed data. The first scheme, called optimum sensor selection (OSS), uses all sensor observations to compute the metric used to rank each candidate subset The second scheme, called selection by averaging over unseen sensors (SAUS), uses only the observations of the candidate subset to compute the ranking metric. The third approach, called GSAUS, is a distributed greedy sensor selection scheme based on SAUS. The performance of each proposed scheme is evaluated by Monte Carlo simulation for a Gaussian shift-in-mean hypothesis testing problem so that a comparison between the various sensor selection schemes can be performed. The results indicate that proper distributed selection approaches can provide performance close to the optimum centralized selection approaches and significant Improvement over random selection, an approach which has been suggested in the past. A particular approach called the ordered magnitude log-likelihood ratio (OLLR) approach, which,was suggested previously for a different problem formulation, looks especially attractive. C1 [Blum, Rick S.; Xu, Zhemin] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Blum, RS (reprint author), Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. EM rblum@eecs.lehigh.edu; zhx4@lehigh.edu; bsadler@arl.army.mil FU National Science Foundation [CCF-0829958]; U.S. Army Research Office [W911NF-08-1-0449] FX This work was supported in part by the National Science Foundation under Grant No. CCF-0829958, and in part by the U.S. Army Research Office under grant W911NF-08-1-0449. NR 4 TC 2 Z9 2 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-2733-8 PY 2009 BP 618 EP + DI 10.1109/CISS.2009.5054793 PG 3 WC Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BLT78 UT WOS:000270992700116 ER PT B AU Chen, X Blum, R Sadler, BM AF Chen, Xun Blum, Rick Sadler, Brian M. GP IEEE TI A New Scheme for Energy-efficient Estimation in a Sensor Network SO 2009 43RD ANNUAL CONFERENCE ON INFORMATION SCIENCES AND SYSTEMS, VOLS 1 AND 2 LA English DT Proceedings Paper CT 43rd Annual Conference on Information Sciences and Systems CY MAR 18-20, 2009 CL Baltimore, MD SP Johns Hopkins Univ, Dept Elect & Comp Engn, IEEE Informat Theory Soc DE energy efficiency; ML-estimation; sensor network; ordered transmissions AB In this paper, energy efficient estimation of an unknown parameter in Gaussian noise is studied in a sensor networking context. A new approach is suggested to obtain a good approximation to the traditional maximum likelihood (ML) estimate, which can save energy by reducing the number of sensor transmissions. Specifically, we describe a new and simple transmission scheme in which the sensor transmissions are ordered according to the magnitude of their measurements, and the sensors with small magnitude measurements, smaller than a threshold, do not transmit. A bound on the error of approximation is derived, which can be utilized to dynamically determine the threshold such that a trade-off between the accuracy of the approximation and the energy savings can be maintained. Through the numerical results, we show that our approach can be very energy efficient with only a negligible estimation error introduced. C1 [Chen, Xun; Blum, Rick] Lehigh Univ, Dept ECE, Bethlehem, PA 18015 USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Chen, X (reprint author), Lehigh Univ, Dept ECE, Bethlehem, PA 18015 USA. EM xuc204@lehigh.edu; rblum@eecs.lehigh.edu; bsadler@arl.army.mil FU Commonwealth of Pennsylvania, Department of Community and Economic Development, in part by the National Science Foundation [CCF-0829958]; U.S. Army Research Office [W911NF-08-I-0449] FX This work was supported in part by a Grant from the Commonwealth of Pennsylvania, Department of Community and Economic Development, in part by the National Science Foundation under Grant No. CCF-0829958, and in part by the U.S. Army Research Office under grant W911NF-08-I-0449. NR 10 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-2733-8 PY 2009 BP 799 EP + DI 10.1109/CISS.2009.5054827 PG 2 WC Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BLT78 UT WOS:000270992700150 ER PT S AU He, T Tong, L Swami, A AF He, Ting Tong, Lang Swami, Ananthram GP IEEE TI Maximum Throughput of Clandestine Relay SO 2009 47TH ANNUAL ALLERTON CONFERENCE ON COMMUNICATION, CONTROL, AND COMPUTING, VOLS 1 AND 2 SE Annual Allerton Conference on Communication Control and Computing LA English DT Proceedings Paper CT 47th Annual Allerton Conference on Communication, Control, and Computing CY SEP 30-OCT 02, 2009 CL Monticello, IL DE Information flow/Relayed traffic flow; Clandestine relay; Anonymous networking; Intrusion detection AB The maximum throughput of relaying information flows while concealing their presence is studied. The concealment is achieved by embedding transmissions of information flows into truly independent transmission schedules that resemble the normal transmission behaviors without any flow. Such embedding may reduce the throughput for delay-sensitive flows, and the paper provides a quantitative characterization of the level of reduction. Under a strict or average delay constraint, the maximum normalized throughput is measured by the efficiency of the optimal relay algorithms that embed the most flow into given transmission schedules. Exact analytical solutions and closed-form approximations are derived for renewal schedules, verified by simulations on both synthetic traffic and traces. The results reveal general relationships between the clandestine throughput and system parameters including delay constraints, traffic load, and traffic distributions. In particular, the throughput is found to be negatively related to the burstiness of the cover traffic. Moreover, simulations show that the throughputs of renewal traffic with certain power. law interarrival distributions can closely approximate those of actual traces. C1 [He, Ting] IBM TJ Watson Res Ctr, Hawthorne, NY 10532 USA. [Tong, Lang] Cornell Univ, Sch Elect & Comp Engn, Phillips Hall, Ithaca, NY 14853 USA. [Swami, Ananthram] US Army, Res Lab, Adelphi, MD 20783 USA. RP He, T (reprint author), IBM TJ Watson Res Ctr, Hawthorne, NY 10532 USA. EM the@us.ibm.com; lt35@cornell.edu; aswami@arl.army.mil FU U.S. Army Research Laboratory and the U.K. Ministry of Defence [W911NF-06-3-0001]; National Science Foundation [CCF-0635070] FX Research was sponsored in part by the U.S. Army Research Laboratory and the U.K. Ministry of Defence under Agreement Number W911NF-06-3-0001 and the National Science Foundation under award CCF-0635070 NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2474-0195 BN 978-1-4244-5870-7 J9 ANN ALLERTON CONF PY 2009 BP 1082 EP + DI 10.1109/ALLERTON.2009.5394874 PG 2 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA BPQ13 UT WOS:000279627100148 ER PT B AU Ganesh, S Sethi, A Hardy, R AF Ganesh, Shriram Sethi, Adarshpal Hardy, Rommie BE Medhi, D Tipper, D Doucette, J TI Lightweight Scheme for Generating Stealthy Probes SO 2009 7TH INTERNATIONAL WORKSHOP ON THE DESIGN OF RELIABLE COMMUNICATION NETWORKS (DRCN 2009) LA English DT Proceedings Paper CT 7th International Workshop on the Design of Reliable Communication Networks CY OCT 25-28, 2009 CL Washington, DC SP Univ Pittsburgh, AT & T, IEEE, IEEE Commun Soc DE stealthy probing; intrusion detection; network management; packet stamping AB Probing based approaches have been effectively used for network monitoring in the past. Probes such as ICMP pings provide an effective tool for detecting compromised nodes which try to delay or drop traffic. But an intelligent attacker may evade detection by giving preferential treatment to probe traffic. This is usually possible because probe packets have a different format from regular application packets and are easily distinguishable. The solution to this problem is to create stealthy probes which are indistinguishable from normal application traffic. In this paper, we build upon our earlier work on the design approaches for stealthy probing, and we propose a lightweight and effective scheme for generating stealthy probes. C1 [Ganesh, Shriram; Sethi, Adarshpal] Univ Delaware, Newark, DE 19716 USA. [Hardy, Rommie] US Army, Res Lab, Adelphi, MD USA. RP Ganesh, S (reprint author), Univ Delaware, Newark, DE 19716 USA. EM ganesh@cis.udel.edu; sethi@cis.udel.edu; rhardy@arl.army.mil FU U.S. Army Research Laboratory under the Collaborative Technology Alliance Program; Cooperative Agreement [DAAD19-01-2-0011] FX Prepared through collaborative participation in the Communications and Networks Consortium sponsored by the U.S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation thereon. NR 19 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5047-3 PY 2009 BP 212 EP + DI 10.1109/DRCN.2009.5340003 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BVV12 UT WOS:000292860600028 ER PT S AU Reed, NE Nie, YH Mahnke, CB AF Reed, Nancy E. Nie, Yanhan Mahnke, C. Becket GP IEEE TI A portable graphical representation tool for phonocardiograms SO 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20 SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society CY SEP 03-06, 2009 CL Minneapolis, MN SP IEEE Engn Med & Biol Soc ID AUSCULTATION SKILLS AB This paper describes a prototype software application to display graphical and editable representations of patient data for use in electronic medical records (EMRs). The application dynamically generates graphics of cardiac and other patient data, and displays or saves them both in graphic and in text formats. The presentation of heart and other data in a consistent, clinically familiar, graphical format is designed to reduce the time necessary for anyone to review and understand this important information. Results of preliminary testing on actual case data are encouraging. C1 [Reed, Nancy E.; Nie, Yanhan] Univ Hawaii, Dept Informat & Comp Sci, 1680 East West Rd, Honolulu, HI 96822 USA. [Mahnke, C. Becket] Tripler Army Med Ctr, Div Pediat Cardiol, Honolulu, HI 96859 USA. RP Reed, NE (reprint author), Univ Hawaii, Dept Informat & Comp Sci, 1680 East West Rd, Honolulu, HI 96822 USA. EM nreed@hawaii.edu; yanhan@hawaii.edu; Christopher.Mahnke@us.army.mil FU Telemedicine and Advanced Technology Research Center of the Army's Advanced Medical Technology Initiative (AAMTI) program FX This work was supported in part by the Telemedicine and Advanced Technology Research Center of the Armys Advanced Medical Technology Initiative (AAMTI) program. NR 18 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-3295-0 J9 IEEE ENG MED BIO PY 2009 BP 3111 EP 3114 DI 10.1109/IEMBS.2009.5332544 PG 4 WC Engineering, Biomedical SC Engineering GA BQB05 UT WOS:000280543602142 ER PT S AU Mahnke, CB AF Mahnke, C. Becket GP IEEE TI Automated heartsound analysis/Computer-aided auscultation: A cardiologist's perspective and suggestions for future development SO 2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20 SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society CY SEP 03-06, 2009 CL Minneapolis, MN SP IEEE Engn Med & Biol Soc ID SYSTOLIC MURMURS; DISEASE; CHILDREN; SKILLS; PHONOCARDIOGRAPHY AB Heart disease is a major cause of worldwide morbidity and mortality. Properly performed, the cardiac auscultatory examination (listening to the heart with a stethoscope) is an inexpensive, widely available tool in the detection and management of heart disease. Unfortunately, accurate interpretation of heartsounds by primary care providers is fraught with error, leading to missed diagnosis of disease and/or excessive costs associated with evaluation of normal variants. Therefore, automated heartsound analysis, also known as computer aided auscultation (CAA), has the potential to become a cost-effective screening and diagnostic tool in the primary care setting. A cardiologist's suggestions for CAA system design and algorithmic development are provided. C1 Tripler Army Med Ctr, Dept Pediat Cardiol, Honolulu, HI 96859 USA. RP Mahnke, CB (reprint author), Tripler Army Med Ctr, Dept Pediat Cardiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Christopher.Mahnke@us.army.mil NR 24 TC 6 Z9 6 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-3295-0 J9 IEEE ENG MED BIO PY 2009 BP 3115 EP 3118 DI 10.1109/IEMBS.2009.5332551 PG 4 WC Engineering, Biomedical SC Engineering GA BQB05 UT WOS:000280543602143 ER PT B AU Okusaga, O Zhou, WM Levy, E Horowitz, M Carter, G Menyuk, C AF Okusaga, Olukayode Zhou, Weimin Levy, Etgar Horowitz, Moshe Carter, Gary Menyuk, Curtis GP IEEE TI Non-ideal Loop-Length-Dependence of Phase Noise in OEOs SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD ID OSCILLATOR AB We present an experimental study of the phase noise spectrum's dependence oil the loop length in OEOs. As the loop length increases, the spectrum deviates significantly from the ideal dependence. (C) 2009 Optical Society of America C1 [Okusaga, Olukayode; Zhou, Weimin] US Army, Res Lab, Adelphi, MD 20783 USA. [Okusaga, Olukayode; Carter, Gary; Menyuk, Curtis] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA. [Levy, Etgar; Horowitz, Moshe] Technion Israel Inst Technol, Haifa, Israel. RP Okusaga, O (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM OOkusaga@arl.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 19 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751300010 ER PT B AU Zhang, JW Guo, X Fan, L Zou, YK Craley, J AF Zhang, J. W. Guo, X. Fan, L. Zou, Y. K. Craley, J. GP IEEE TI Night Vision Enhancement Technology with Pyroelectric Field Driven Liquid Crystal Display SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB A novel night vision enhancement technology based on IR to visible light translation was demonstrated with a specifically designed liquid crystal cell sandwiched with pyroelectric and glass plates, which can be viewed by naked eyes. (C) 2009 Optical Society of America. C1 [Zhang, J. W.; Guo, X.; Fan, L.; Zou, Y. K.] Boston Appl Technol Inc, 6F Gill St, Woburn, MA 01801 USA. [Craley, J.] US Army, Natick Soldier RD & E Ctr, Natick, MA 01760 USA. RP Zhang, JW (reprint author), Boston Appl Technol Inc, 6F Gill St, Woburn, MA 01801 USA. EM jwzhang@bostonati.com; Jason.Craley@us.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 140 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751300071 ER PT B AU Dubinskii, M Zhang, J Ter-Mikirtychev, V AF Dubinskii, M. Zhang, J. Ter-Mikirtychev, V. GP IEEE TI Power Scaling of Yb-Free, Er-Doped Fiber Laser with Resonant Clad Pumping SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB We report resonantly cladding-pumped Yb-free Er-doped fiber laser delivering similar to 48 W of CW output at 1590 nm with similar to 57% efficiency. It is believed to be the highest power ever reported from Yb-free, Er-doped LMA fiber. (C)2009 Optical Society of America C1 [Dubinskii, M.; Zhang, J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Dubinskii, M (reprint author), USA, Res Lab, 2800 Powder Hill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 151 EP 152 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751300077 ER PT B AU Garrett, GA Moe, CG Reed, ML Wraback, M Sun, WH Shatalov, M Hu, XH Yang, JW Bilenko, Y Lunev, A Shur, MS Gaska, R AF Garrett, Gregory A. Moe, Craig G. Reed, Meredith L. Wraback, Michael Sun, Wenhong Shatalov, Max Hu, Xuhong Yang, Jinwei Bilenko, Yuriy Lunev, Alex Shur, Michael S. Gaska, Remis GP IEEE TI Time-Resolved Photoluminescence Studies of AlGaN-based Deep UV LED Structures Emitting Down to 229 nm SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB Photoluminescence lifetime and internal quantum efficiency measurements of deep ultraviolet (similar to 230 nm) light-emitting diode structures are correlated to packaged devices and compared to measurements on more mature 280 nm structures. (C) 2009 Optical Society of America C1 [Garrett, Gregory A.; Moe, Craig G.; Reed, Meredith L.; Wraback, Michael] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Garrett, GA (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ggarrett@arl.army.mil RI Shur, Michael/A-4374-2016 OI Shur, Michael/0000-0003-0976-6232 NR 3 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 385 EP 386 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751300194 ER PT B AU Sampath, AV Garrett, GA Sarney, WL Shen, H Wraback, W Grandusky, JR Schowalter, LJ AF Sampath, A. V. Garrett, G. A. Sarney, W. L. Shen, H. Wraback, W. Grandusky, James R. Schowalter, Leo J. GP IEEE TI The Effects of Increasing AlN Mole Fraction on the Performance of AlGaN based Ultraviolet Light Emitting Diode Active Regions SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB Time-resolved photoluminescence and transmission electron microscopy results suggest that the density of point defects may have a more significant role than threading dislocations in the performance of UVLED AlGaN active regions emitting at shorter wavelengths. C1 [Sampath, A. V.; Garrett, G. A.; Sarney, W. L.; Shen, H.; Wraback, W.] USA, Res Lab, Adelphi, MD 20783 USA. RP Sampath, AV (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 4 TC 0 Z9 0 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 389 EP 390 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751300196 ER PT B AU Reed, ML Shen, H Wraback, M Syrkin, A Usikov, A AF Reed, M. L. Shen, H. Wraback, M. Syrkin, A. Usikov, A. GP IEEE TI Electro-Optical Properties of n-InGaN/p-GaN LED with p-side Down With Varying Indium Composition SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB The negative polarization charge at the n-InGaN/p-GaN interface of single heterojunction LEDs with p-side down are investigated for various In-compositions. We demonstrate peak emission wavelength blue-shift and intensity dependence on In-composition with increasing current density. (C)2009 Optical Society of America C1 [Reed, M. L.; Shen, H.; Wraback, M.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Syrkin, A.; Usikov, A.] Technol Device Int Inc, Silver Spring, MD 20904 USA. RP Reed, ML (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM Meredith.L.Reed@us.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 564 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751300284 ER PT B AU Safaisini, R Joseph, JR Dang, G Lear, KL AF Safaisini, Rashid Joseph, John R. Dang, Gerard Lear, Kevin L. GP IEEE TI Uniform high bandwidth, high CW power VCSEL arrays SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB A high bandwidth, high power, 980 nm vertical-cavity surface-emitting laser (VCSEL) array with 3dB frequency response over 7.5 GHz and continuous wave (CW) power of greater than 120 mW at room temperature is reported. (C) 2006 Optical Society of America C1 [Safaisini, Rashid; Joseph, John R.; Lear, Kevin L.] Colorado State Univ, Dept Elect & Comp Engn, Ft Collins, CO 80523 USA. [Dang, Gerard] US Army Res Lab, Adelphi, MD 20783 USA. RP Safaisini, R (reprint author), Colorado State Univ, Dept Elect & Comp Engn, Ft Collins, CO 80523 USA. EM kllear@engr.colostate.edu NR 2 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 692 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751300348 ER PT B AU Ter-Gabrielyan, N Sanamyan, T Dubinskii, N AF Ter-Gabrielyan, N. Sanamyan, T. Dubinskii, N. GP IEEE TI Eye-safe Pr(3+):RbPb(2)Cl(5) Laser at similar to 1.65 mu m Resonantly-Pumped at 1547 nm SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB Resonantly-pumped laser action based on (3)F(3) double right arrow (3)H(4) transition of Pr(3+) ion is reported for the first time. Pr(3+):RbPb(2)Cl(5) laser demonstrated slope efficiency of over 21% at 1647 nm despite the marginal initial sample quality. (C)2009 Optical Society of America C1 [Ter-Gabrielyan, N.; Sanamyan, T.; Dubinskii, N.] USA, Res Lab, Adelphi, MD USA. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, Adelphi, MD USA. EM mdubinskiy@arl.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 814 EP 815 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751300410 ER PT B AU Metcalfe, GD Shen, HE Wraback, M Koblmuller, G Gallinat, CS Speck, JS AF Metcalfe, Grace D. Shen, Hongen Wraback, Michael Koblmueller, Gregor Gallinat, Chad S. Speck, James S. GP IEEE TI Terahertz Emission from Nonpolar Indium Nitride SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB We present terahertz emission from nonpolar InN due to carrier transport in stacking fault-related internal in-plane electric fields. Evidence of in-plane transport is observed as a terahertz waveform polarity flip with reversal of the c-axis. (C)2009 Optical Society of America C1 [Metcalfe, Grace D.; Shen, Hongen; Wraback, Michael] USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Koblmueller, Gregor; Gallinat, Chad S.; Speck, James S.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. RP Metcalfe, GD (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM grace.metcalfe@us.army.mil NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 1395 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751301021 ER PT B AU Das, NC Chang, W AF Das, N. C. Chang, W. GP IEEE TI Performance Comparison of Bottom and Top Emitting LWIR (8 mu m) LED Devices SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB For similar GaSb substrate thickness, flip-chip mount bottom emitting LWIR LED device has higher light intensity than top emitting device. Enhanced emission is attributed to better cooling and reflection of light from anode metal surface of the device. (C) 2009 Optical society of America C1 [Das, N. C.; Chang, W.] USA, Res Lab, Microphoton Branch, Adelphi, MD 20783 USA. RP Das, NC (reprint author), USA, Res Lab, Microphoton Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ndas@arl.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 1613 EP 1614 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751301130 ER PT B AU Kudryashov, I Katsnelson, A Ter-Gabrielyan, N Dubinskii, M AF Kudryashov, I. Katsnelson, A. Ter-Gabrielyan, N. Dubinskii, M. GP IEEE TI Room Temperature Power Scalability of the Diode-Pumped Er:YAG Eye-Safe Laser SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB Laser performance of the Er:YAG resonantly end-pumped by a high-brightness InGaAsP/InP 10-bar stack is reported. Achieved 80 W power is believed to be the highest CW power ever reported from diode-pumped room-temperature Er:YAG laser. (C) 2009 Optical Society of America C1 [Kudryashov, I.; Katsnelson, A.] Princeton Lightwave Inc, 2555 US Route 130, Cranbury, NJ 08512 USA. [Ter-Gabrielyan, N.; Dubinskii, M.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Kudryashov, I (reprint author), Princeton Lightwave Inc, 2555 US Route 130, Cranbury, NJ 08512 USA. EM mdubinskiy@arl.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 1650 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751301149 ER PT B AU White, JO AF White, Jeffrey O. GP IEEE TI Er:YAG is a 2.5-Level Laser at 300 degrees K SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB We propose the "level parameters" l(0) and l(1) to quantify the concept of two-, three- and four-level laser, for comparing different laser media, operating temperatures, and choices of pump and laser transitions. (C) 2009 Optical Society of America C1 USA, Res Lab, Adelphi, MD 20783 USA. RP White, JO (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jeffrey.owen.white@arl.army.mil NR 1 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 1656 EP 1657 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751301152 ER PT B AU Levy, EC Horowitz, M Menyuk, CR Okusaga, O Zhou, WM Carter, GM AF Levy, Etgar C. Horowitz, Moshe Menyuk, Curtis R. Okusaga, Olukayode Zhou, Weimin Carter, Gary M. GP IEEE TI Modeling opto-electronic oscillators SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB A comprehensive model to accurately study phase noise and dynamics in optoelectronic oscillators is presented. The model results are compared to experiments. The comparison shows that the flicker noise increases as the cavity length increases. (C) 2009 Optical Society of America C1 [Levy, Etgar C.; Horowitz, Moshe] Technion Israel Inst Technol, Dept Elect Engn, IL-32000 Haifa, Israel. [Menyuk, Curtis R.; Carter, Gary M.] Univ Maryland, Dept Elect Engn, Baltimore, MD 21250 USA. [Okusaga, Olukayode; Zhou, Weimin] US Army Res Lab, Adelphi, MD USA. RP Levy, EC (reprint author), Technion Israel Inst Technol, Dept Elect Engn, IL-32000 Haifa, Israel. EM etgarlevy@gmail.com FU DARPA MTO FX This work is supported by DARPA MTO. NR 3 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 2643 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751302306 ER PT B AU Pritchett, TM Wang, JW Lawson, CM Zhao, Q Gray, GM AF Pritchett, Timothy M. Wang, Jianwei Lawson, Christopher M. Zhao, Qun Gray, Gary M. GP IEEE TI Characterization of Nonlinear Absorption in Phosphine-Substituted Bithiophenes SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB The two-photon absorption cross-sections of two novel derivatives of 5,5'-bis(diphenylphosphino)-2,2'-bithiophene have been measured using Z scans employing 27-ps pulses at multiple pulse energies, yielding values of 1500 +/- 50 GM and 2830 +/- 50 GM. (C) 2009 Optical Society of America C1 [Pritchett, Timothy M.] USA, Res Lab, AMSRD ARL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Wang, Jianwei; Lawson, Christopher M.] Univ Alabama Birmingham, Ctr Opt Sensors & Spectroscopy, Birmingham, AL 35294 USA. [Zhao, Qun; Gray, Gary M.] Univ Alabama Birmingham, Dept Chem, Birmingham, AL 35294 USA. RP Pritchett, TM (reprint author), USA, Res Lab, AMSRD ARL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM timothy.pritchett1@us.army.mil NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 3039 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751302505 ER PT B AU Fernandes, GE Kim, JH Liu, ZJ Shainline, J Osgood, R Xu, J AF Fernandes, Gustavo E. Kim, Jin-Ho Liu, Zhijun Shainline, Jeffrey Osgood, Richard, III Xu, Jimmy GP IEEE TI Anomalously High Refractive Index of an Array of Vertically Aligned Gold Nanopillars on Silicon SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB Reflectivity measurements on a film consisting of gold nanopillars surrounded by an anodized aluminum oxide medium suggest a refractive index much larger than that predicted by considering the dispersion curves of gold and aluminum oxide. (C) 2009 Optical Society of America C1 [Fernandes, Gustavo E.; Kim, Jin-Ho; Liu, Zhijun; Shainline, Jeffrey; Xu, Jimmy] Brown Univ, Div Engn, Box D, Providence, RI 02912 USA. [Osgood, Richard, III] US Army, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Fernandes, GE (reprint author), Brown Univ, Div Engn, Box D, Providence, RI 02912 USA. EM Gustavo_Fernandes@Brown.edu NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 3047 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751302509 ER PT B AU Forsythe, EW Shi, J Liu, S Morton, DC Loy, D Lee, YK Bell, C Richards, M Bawolek, E Ageno, S Moyer, C Marrs, M Kaminski, J Colaneri, N O'Rourke, SM Silvernail, J Rajan, K Ma, RQ Hack, M Brown, JJ AF Forsythe, E. W. Shi, J. Liu, S. Morton, D. C. Loy, Doug Lee, Yong Kyun Bell, Cynthia Richards, Mark Bawolek, Ed Ageno, Scott Moyer, Curt Marrs, Michael Kaminski, Jann Colaneri, Nick O'Rourke, Shawn M. Silvernail, Jeff Rajan, Kamala Ma, Ruiqing Hack, Michael Brown, Julie J. GP IEEE TI Future Flexible OLED Displays for Army Applications SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB Organic light emitting diodes have been fabricated on an active matrix backplane from an 180C processed amorphous Si thin film transistors on polyethylene naphthalate (PEN) substrates. Organic light emitting diodes have been fabricated on the active matrix backplane. The presentation will include organic material development from ARL in the context of future Army applications. C1 [Forsythe, E. W.; Shi, J.; Liu, S.; Morton, D. C.] USA, Res Lab, MS AMSRD ARL SE EO, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Loy, Doug; Lee, Yong Kyun; Bell, Cynthia; Richards, Mark; Bawolek, Ed; Ageno, Scott; Moyer, Curt; Marrs, Michael; Kaminski, Jann; Colaneri, Nick; O'Rourke, Shawn M.] Arizona State Univ, Flexible Display Ctr, Tempe, AZ 85284 USA. [Silvernail, Jeff; Rajan, Kamala; Ma, Ruiqing; Hack, Michael; Brown, Julie J.] Universal Display Corp, Ewing, NJ 08618 USA. RP Forsythe, EW (reprint author), USA, Res Lab, MS AMSRD ARL SE EO, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 3234 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751302603 ER PT B AU Swim, C Vanderbeek, R Emge, D AF Swim, Cindy Vanderbeek, Richard Emge, Darren GP IEEE TI Chemical-Biological Detection Overview SO 2009 CONFERENCE ON LASERS AND ELECTRO-OPTICS AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (CLEO/QELS 2009), VOLS 1-5 LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference (CLEO/QELS 2009) CY JUN 02-04, 2009 CL Baltimore, MD AB State-of-the-art sensors and emerging technologies are under development for chemical and biological agent defense. Spectroscopic approaches such as differential scattering, depolarization, and Raman will be discussed. (C) 2009 Optical Society of America C1 [Swim, Cindy; Vanderbeek, Richard; Emge, Darren] USA, Edgewood Chem Biol Ctr, Edgewood, MD 21010 USA. RP Swim, C (reprint author), USA, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd,AMSRD ECB RT D, Edgewood, MD 21010 USA. EM cynthia.swim@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5184-5 PY 2009 BP 3251 EP 3252 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BNJ62 UT WOS:000274751302613 ER PT B AU Nasrabadi, NM AF Nasrabadi, Nasser M. GP IEEE TI KERNEL SUBSPACE-BASED ANOMALY DETECTION FOR HYPERSPECTRAL IMAGERY SO 2009 FIRST WORKSHOP ON HYPERSPECTRAL IMAGE AND SIGNAL PROCESSING: EVOLUTION IN REMOTE SENSING LA English DT Proceedings Paper CT 1st Workshop on Hyperspectral Image and Signal Processing - Evolution in Remote Sensing CY AUG 26-29, 2009 CL Grenoble, FRANCE SP IEEE Geosci & Remote Sensing Soc DE Anomaly detection; kernel machine learning ID EIGENSPACE SEPARATION TRANSFORM AB This paper provides a performance comparison of various linear and nonlinear subspace-based anomaly detectors. Three different techniques, Principal Component Analysis (PCA), Fisher Linear Discriminant (FLD) Analysis, and the Eigenspace Separation Transform (EST), are used to generate the linear projection subspaces. Each of these three linear methods is then extended to its corresponding nonlinear kernel version. The well-known Reed-Xiaoli (RX) anomaly detector and its kernel version (kernel RX) are also implemented. Comparisons between all linear and non-linear anomaly detectors are made using receiver operating characteristics (ROC) curves for several hyperspectral imagery. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Nasrabadi, NM (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-4686-5 PY 2009 BP 83 EP 86 PG 4 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BOC66 UT WOS:000276190400021 ER PT B AU Pelaez, JC Fernandez, EB AF Pelaez, Juan C. Fernandez, Eduardo B. BE Danubianu, M Noll, J Dini, C TI VoIP Network Forensic Patterns SO 2009 FOURTH INTERNATIONAL MULTI-CONFERENCE ON COMPUTING IN THE GLOBAL INFORMATION TECHNOLOGY (ICCGI 2009) LA English DT Proceedings Paper CT 4th International Multi-Conference on Computing in the Global Information Technology CY AUG 23-29, 2009 CL Cannes, FRANCE DE forensic patterns; network architecture; software architecture; Voice over IP AB We discuss a systematic approach to network forensic collection and analysis of data in converged networks. Since attacks cannot be completely avoided, it is necessary to have appropriate forensics systems. Upon integration into a network forensic infrastructure, we expect this forensic model will enable a faster response and more structured investigations of VoIP-based network attacks. C1 [Pelaez, Juan C.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Fernandez, Eduardo B.] Florida Atlantic Univ, Dept Comp Sci & Engn, Boca Raton, FL 33433 USA. RP Pelaez, JC (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM juan.c.pelaez@arl.army.mil; ed@cse.fau.edu NR 13 TC 3 Z9 3 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-4680-3 PY 2009 BP 175 EP + DI 10.1109/ICCGI.2009.53 PG 2 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BUL11 UT WOS:000289710400030 ER PT B AU Tahmoush, D Silvious, J AF Tahmoush, Dave Silvious, Jerry GP IEEE TI Radar Micro-Doppler for Long Range Front-View Gait Recognition SO 2009 IEEE 3RD INTERNATIONAL CONFERENCE ON BIOMETRICS: THEORY, APPLICATIONS AND SYSTEMS LA English DT Proceedings Paper CT 3rd IEEE International Conference on Biometrics - Theory, Applications and Systems (BTAS 2009) CY SEP 28-30, 2009 CL Washington, DC SP IEEE, IEEE Syst, Man & Cybernet Soc, IEEE Biometr Council ID MODEL AB We seek to understand the extraction of radar micro-Doppler signals generated by human motions at long range and with a front-view to use them as a biometric. We describe micro-Doppler algorithms used for the detection and tracking, and detail the gait features that can be extracted. We have measurements of multiple human subjects in outdoor but low-clutter backgrounds for identification and find that at long range and front-view, the probability of correct classification can be over 80%. However, the micro-Doppler signals are dependent on the direction of motion, and we discuss methods to reduce the effect of the direction of motion. These radar biometric features can serve as identifying features in a scene with multiple subjects. Ground truth using video and GPS is used to validate the radar data. C1 [Tahmoush, Dave; Silvious, Jerry] USA, Res Lab, Adelphi, MD 20783 USA. RP Tahmoush, D (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 33 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5019-0 PY 2009 BP 346 EP 351 PG 6 WC Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic; Mathematical & Computational Biology; Statistics & Probability SC Computer Science; Engineering; Mathematical & Computational Biology; Mathematics GA BOC54 UT WOS:000276176000055 ER PT S AU Rock, JC Hudson, T Wolfson, B Lawrence, D Pillans, B Brown, AR Coryell, L AF Rock, Janice C. Hudson, Tracy Wolfson, Brandon Lawrence, Daniel Pillans, Brandon Brown, Andrew R. Coryell, Louis GP IEEE TI A MEMS-Based, Ka-Band, 16-Element Sub-Array SO 2009 IEEE AEROSPACE CONFERENCE, VOLS 1-7 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2009 IEEE Aerospace Conference CY MAR 07-14, 2009 CL Big Sky, MT ID DESIGN AB The Aviation and Missile Research, Development and Engineering Center (AMRDEC) has been involved in an Army Technology Objective (ATO) aimed at furthering phased arrays for both tactical seekers and communication links. The ATO has been pursuing both MicroElectroMechanical Systems (MEMS) and MMIC-based phase shifters with an overall goal of $50K for a tactical seeker at Ka-band and $5K for a communication link at Ku-band. (1,2) In a collaborative effort with the Communications-Electronics Research, Development and Engineering Center (CERDEC), the AMRDEC has worked to improve the maturity of Radio Frequency (RF) M EMS devices for use in phase shifters for phased arrays. This paper shows that RF MEMS have vastly improved in reliability over the past few years. This paper presents the background and most current results of a task to implement a 16-element phased sub-array with RF MEMS-based phase shifters. The slat is centered at 33.4GHz and utilizes 1/2-wavelength spacing between elements. The individual elements consist of Vivaldi antennas. Taylor Weighting is applied to lower the overall sidelobes. This paper discusses the MEMS design being produced and the current maturity of the design. It also discusses the insertion loss, power consumption, linearity and reliability of the phasing network. C1 [Rock, Janice C.; Hudson, Tracy] USA, Aviat & Missile Res Dev & Engn Ctr, AMSRD AMR WD UR, Redstone Arsenal, AL 35898 USA. [Wolfson, Brandon; Lawrence, Daniel] Technol Serv Corp, Huntsville, AL 35805 USA. [Pillans, Brandon] Adv Prod Ctr, Raytheon Space & Airborne Syst, Dallas, TX 75243 USA. [Brown, Andrew R.] Brown Design, Northvale, NJ 48167 USA. [Coryell, Louis] US Army Commun Elect Dev & Engn Ctr, AMSRD CER ST SS TS, Ft Monmouth, NJ 07703 USA. RP Rock, JC (reprint author), USA, Aviat & Missile Res Dev & Engn Ctr, AMSRD AMR WD UR, Redstone Arsenal, AL 35898 USA. EM janice.rock@us.army.mil; tracy.hudson@us.army.mil; brandon.wolfson@phaseiv.com; dan.lawrence@phaseiv.com; b-pillans@raytheon.com; Andrew.r.brown@sbcglobal.net; Louis.coryell@us.armny.mil NR 10 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 978-1-4244-2621-8 J9 AEROSP CONF PROC PY 2009 BP 665 EP + PG 4 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA BME07 UT WOS:000271964000062 ER PT S AU Booth, JP Read, S Allen, B AF Booth, Joel P. Read, Sonya Allen, Barry GP IEEE TI Weather and Propagation Effects on Multi-Mode Seeker Systems SO 2009 IEEE AEROSPACE CONFERENCE, VOLS 1-7 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2009 IEEE Aerospace Conference CY MAR 07-14, 2009 CL Big Sky, MT AB This paper will discuss the progression of army seeker systems from a single mode to a multi-mode configuration. This progression is in part due to the effects of weather on seeker system performance. This discussion will be based on computer simulations and climatological data and test data. The relationships between frequency and range will be explored as they interact with the weather. This effort is being conducted in the RF Technology Function of the Applied Sensors, Guidance, and Electronics Division, U.S. Army Aviation and Missile Research, Development, and Engineering Center (AMRDEC) on the Redstone Arsenal in Huntsville, Alabama. While there is extensive work in this area, which is represented here in a condensed form, this paper will go into greater detail of the attenuation due to rainfall rates and cloud water content. The ground work for this effort was described in a paper "Weather and Radar Interactions. This research is a continuation of that work. The goal is to update the current trend in seeker development. The data obtained front this effort will be used to support the selection of new seeker system parameters. The effects of the weather would impact the selection of operating frequency and modes. This paper will also present some of the early test bed results of multimode seeker trials. (12) C1 [Booth, Joel P.; Read, Sonya; Allen, Barry] USA, Aviat & Missile Command, Ctr Dev & Engn, AMSRD AMR WD UR, Redstone Arsenal, AL 35898 USA. RP Booth, JP (reprint author), USA, Aviat & Missile Command, Ctr Dev & Engn, AMSRD AMR WD UR, Redstone Arsenal, AL 35898 USA. EM Joel.booth@rdec.redstone.army.mil NR 16 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 978-1-4244-2621-8 J9 AEROSP CONF PROC PY 2009 BP 676 EP 684 PG 9 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA BME07 UT WOS:000271964000063 ER PT S AU Patrick, R Smith, MJ Zhang, B Byington, CS Vachtsevanos, GJ Del Rosario, R AF Patrick, Romano Smith, Matthew J. Zhang, Bin Byington, Carl S. Vachtsevanos, George J. Del Rosario, Romeo GP IEEE TI Diagnostic Enhancements for Air Vehicle HUMS to Increase Prognostic System Effectiveness SO 2009 IEEE AEROSPACE CONFERENCE, VOLS 1-7 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2009 IEEE Aerospace Conference CY MAR 07-14, 2009 CL Big Sky, MT AB A major objective of Health and Usage Monitoring Systems (HUMS) is to transition from time based part replacement to performing maintenance actions based on evidence of need. While existing HUMS capability has demonstrated progress, the ability to diagnose component faults in their early stages is limited. This is due in part to sensitivity to signal noise, variations in environmental and operating conditions, and underutilization of prognostic techniques. Using the representative example of the fan support bearing in the oil cooler of the UH-60 helicopter, this paper discusses key areas to improve fault detection methods for health monitoring of a damaged helicopter transmission component. These include: (1) sensing and data processing tools, (2) selection and extraction of optimum condition indicators/features, (3) fusion of data at the sensor and feature levels, and (4) incipient fault detection using a Bayesian estimation framework. Results illustrating the effectiveness of these techniques are presented for fielded UH-60 bearing vibration data and laboratory test results.(12) C1 [Patrick, Romano; Smith, Matthew J.; Byington, Carl S.] Impact Technol LLC, 200 Canal View Blvd, Rochester, NY 14623 USA. [Zhang, Bin; Vachtsevanos, George J.] Georgia Inst Technol, Elect & Comp Engn, Atlanta, GA 30332 USA. [Del Rosario, Romeo] US Army, Res Lab, AMSRD ARL SE RE, Adelphi, MD 20783 USA. RP Patrick, R (reprint author), Impact Technol LLC, 200 Canal View Blvd, Rochester, NY 14623 USA. EM romano.patrick@impact-tek.com; matthew.smith@impact-tek.com; bin.zhang@gatech.edu; carl.byington@impact-tek.com; gjv@ece.gatech.edu; romeo@arl.army.mil FU Army Research Laboratory [W911NF-07-2-0075] FX This work has been partially supported with a cooperative agreement by the Army Research Laboratory under contract number W911NF-07-2-0075. In addition to the primary authors, we would like to thank government and contractor representatives from organizations supporting the Army Utility (Blackhawk) Program Manager including Mr. Don Estes, Mr. Carlos Rivera, and Dr. Jon Keller. This work has also benefitted greatly from consultations with other Army Research Laboratory and NASA Glenn researchers such as: Dr. Timothy Krantz, Dr. David Lewicki, Dr. Harry Decker, Dr. Hiralal Khatri, Mr. Ken Ranney and Mr. Kwok Tom. NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 978-1-4244-2621-8 J9 AEROSP CONF PROC PY 2009 BP 3486 EP + PG 3 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA BME07 UT WOS:000271964001094 ER PT S AU Rabeno, E Bounds, M AF Rabeno, Eric Bounds, Mark GP IEEE TI Condition Based Maintenance of Military Ground Vehicles SO 2009 IEEE AEROSPACE CONFERENCE, VOLS 1-7 SE IEEE Aerospace Conference Proceedings LA English DT Proceedings Paper CT 2009 IEEE Aerospace Conference CY MAR 07-14, 2009 CL Big Sky, MT AB The performance of military ground vehicle systems quickly degrades due to high operation tempo and extreme environments while performing in-theater service. Current maintenance methods associated with this degradation are not sufficiently optimized for cost and performance. To address this issue, the United States Army is implementing a policy of Condition Based Maintenance (CBM) and being supported by the Army Materiel System Analysis Activity (AMSAA). CBM is a plan of maintenance for a system based upon the actual condition of the system as enabled by the application of usage, diagnostic and prognostic processes executed on a Health and Usage Monitoring System (HUMS). AMSAA has developed and is implementing a CBM system for ground vehicles. This development process has included the development of a robust military-grade HUMS in conjunction with the Aberdeen Test Center and the development of data collection, reduction, analysis, and reporting processes. A key requirement underlying these processes is a thorough understanding of both the ways in which system condition is degenerated and the ability of the HUMS to detect, identify, and communicate all conditions that requires maintenance in a timely manner. AMSAA and the US Army Aberdeen Test Center (ATC) have jointly initiated testing and applications as the critical means of filling this requirement.(1 2) C1 [Rabeno, Eric; Bounds, Mark] USA, Mat Syst Anal Activ AMSAA, Aberdeen Proving Ground, MD 21005 USA. RP Rabeno, E (reprint author), USA, Mat Syst Anal Activ AMSAA, 392 Hopkins Rd,Bldg 392 AMSRD AMS LA, Aberdeen Proving Ground, MD 21005 USA. EM eric.l.rabeno@us.army.mil; mark.s.bounds@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1095-323X BN 978-1-4244-2621-8 J9 AEROSP CONF PROC PY 2009 BP 3792 EP 3797 PG 6 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA BME07 UT WOS:000271964001124 ER PT B AU Goldman, GH AF Goldman, Geoffrey H. GP IEEE TI Frequency Scanning Antenna Concept with Random Feed Lengths SO 2009 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM AND USNC/URSI NATIONAL RADIO SCIENCE MEETING, VOLS 1-6 LA English DT Proceedings Paper CT IEEE Antennas and Propagation International Symposium /USNC/URSI National Radio Science Meeting CY JUN 01-05, 2009 CL N Charleston, SC SP IEEE, USNC, URSI C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Goldman, GH (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM ggoldman@arl.army.mil NR 5 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3646-0 PY 2009 BP 357 EP 360 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BON71 UT WOS:000277085400091 ER PT B AU Zaghloul, AI Kilic, O DaSilva, LA Midkiff, SF AF Zaghloul, Amir I. Kilic, Ozlem DaSilva, Luiz A. Midkiff, Scott F. GP IEEE TI Satellite-Based Assured Communications for Critical Mobile Network Infrastructure SO 2009 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM AND USNC/URSI NATIONAL RADIO SCIENCE MEETING, VOLS 1-6 LA English DT Proceedings Paper CT IEEE Antennas and Propagation International Symposium /USNC/URSI National Radio Science Meeting CY JUN 01-05, 2009 CL N Charleston, SC SP IEEE, USNC, URSI AB This paper presents a concept for a satellite-based solution for assured communications for mobile public safety groups, law enforcement vehicles and other first responders. System connectivity is assured under normal operating conditions through a combination of wireless base stations and, in areas with minimal or no existing terrestrial communications infrastructure or following a disaster, satellite communications. The proposed solution alleviates critical barriers to the adoption of satellite communications as the backup system by using on-demand services, allowing the rapid and cost-effective configuration of satellite links and a wireless mesh network to support voice and data communications. C1 [Zaghloul, Amir I.; DaSilva, Luiz A.; Midkiff, Scott F.] Virginia Polytech Inst & State Univ, Blacksburg, VA 22043 USA. [Kilic, Ozlem] Catholic Univ Amer, Washington, DC 20064 USA. [Zaghloul, Amir I.] US Army Res Lab, Adelphi, MD 20783 USA. RP Zaghloul, AI (reprint author), Virginia Polytech Inst & State Univ, Blacksburg, VA 22043 USA. EM amirz@vt.edu; kilic@cua.edu; ldasilva@vt.edu; midkiff@vt.edu NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3646-0 PY 2009 BP 1320 EP + PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BON71 UT WOS:000277085400332 ER PT B AU Tahmoush, D Silvious, J AF Tahmoush, Dave Silvious, Jerry GP IEEE TI Angle, Elevation, PRF, and Illumination in Radar Micro Doppler for Security Applications SO 2009 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM AND USNC/URSI NATIONAL RADIO SCIENCE MEETING, VOLS 1-6 LA English DT Proceedings Paper CT IEEE Antennas and Propagation International Symposium /USNC/URSI National Radio Science Meeting CY JUN 01-05, 2009 CL N Charleston, SC SP IEEE, USNC, URSI C1 [Tahmoush, Dave; Silvious, Jerry] USA, Res Lab, Adelphi, MD 20783 USA. RP Tahmoush, D (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM david.tahmoush@us.army.mil NR 7 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3646-0 PY 2009 BP 1332 EP 1335 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BON71 UT WOS:000277085400335 ER PT B AU Tahmoush, D Sivious, J AF Tahmoush, Dave Sivious, Jerry GP IEEE TI Radar MicroDoppler for Security Applications: Modeling Men versus Women SO 2009 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM AND USNC/URSI NATIONAL RADIO SCIENCE MEETING, VOLS 1-6 LA English DT Proceedings Paper CT IEEE Antennas and Propagation International Symposium /USNC/URSI National Radio Science Meeting CY JUN 01-05, 2009 CL N Charleston, SC SP IEEE, USNC, URSI ID MOTION C1 [Tahmoush, Dave; Sivious, Jerry] USA, Res Lab, Adelphi, MD 20783 USA. RP Tahmoush, D (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM david.tahmoush@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3646-0 PY 2009 BP 1336 EP 1339 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BON71 UT WOS:000277085400336 ER PT B AU Kenyon, C AF Kenyon, Christopher GP IEEE TI Optimization of a Resistively-Loaded Horn for Mine Detection SO 2009 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM AND USNC/URSI NATIONAL RADIO SCIENCE MEETING, VOLS 1-6 LA English DT Proceedings Paper CT IEEE Antennas and Propagation International Symposium /USNC/URSI National Radio Science Meeting CY JUN 01-05, 2009 CL N Charleston, SC SP IEEE, USNC, URSI AB Five basic versions of an U.S. Army Research Laboratory (ARL) built Synchronous Impulse Reconstruction (SIRE) radar antenna were modeled using the method of moments (MOM) algorithm in FEKO computational electromagnetics software with the goal of improving the antenna performance. The antennas consist of two-sided, open horns where horizontal, resistively loaded parallel plates were attached at the radiating end of the horn. Three of the models featured cylindrical flares attached to the end of the parallel plates. Each of the five versions was optimized over a small range of geometry and resistance parameters. The computations predicted that the design using resistive sheets in the parallel line structure with no flare had the best performance because of its combination of favorably low S11 parameters and forward-directed vertical electric far field. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Kenyon, C (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ckenyon@arl.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3646-0 PY 2009 BP 1340 EP 1343 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BON71 UT WOS:000277085400337 ER PT B AU Weiss, S AF Weiss, Steven GP IEEE TI Radiation from Transverse Sources Using Coupled Vector Potentials SO 2009 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM AND USNC/URSI NATIONAL RADIO SCIENCE MEETING, VOLS 1-6 LA English DT Proceedings Paper CT IEEE Antennas and Propagation International Symposium /USNC/URSI National Radio Science Meeting CY JUN 01-05, 2009 CL N Charleston, SC SP IEEE, USNC, URSI C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Weiss, S (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM sweiss@arl.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3646-0 PY 2009 BP 2387 EP 2390 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BON71 UT WOS:000277085401127 ER PT B AU Anthony, TK Zaghloul, AI AF Anthony, Theodore K. Zaghloul, Amir I. GP IEEE TI Designing a 32 Element Array at 76GHz with a 33dB Taylor Distribution in Waveguide for a Radar System SO 2009 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM AND USNC/URSI NATIONAL RADIO SCIENCE MEETING, VOLS 1-6 LA English DT Proceedings Paper CT IEEE Antennas and Propagation International Symposium /USNC/URSI National Radio Science Meeting CY JUN 01-05, 2009 CL N Charleston, SC SP IEEE, USNC, URSI C1 [Anthony, Theodore K.; Zaghloul, Amir I.] USA, Res Lab, Adelphi, MD 20783 USA. RP Anthony, TK (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM tanthony@arl.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3646-0 PY 2009 BP 2539 EP 2542 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BON71 UT WOS:000277085401165 ER EF