FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Ragel, BT
Klimo, P
Martin, JE
Teff, RJ
Bakken, HE
Armonda, RA
AF Ragel, Brian T.
Klimo, Paul, Jr.
Martin, Jonathan E.
Teff, Richard J.
Bakken, Hans E.
Armonda, Rocco A.
TI Wartime decompressive craniectomy: technique and lessons learned
SO NEUROSURGICAL FOCUS
LA English
DT Article
DE battlefield; decompressive craniectomy; military
ID PENETRATING CRANIOCEREBRAL INJURIES; MIDDLE CEREBRAL-ARTERY; SEVERE
HEAD-INJURY; INTRACRANIAL HYPERTENSION; NEUROSURGICAL EXPERIENCE;
TRAUMATIC BRAIN; BULLET VELOCITY; INFARCTION; LEBANON; WOUNDS
AB Object. Decompressive craniectomy (DC) with dural expansion is a life-saving neurosurgical procedure performed for recalcitrant intracranial hypertension due to trauma, stroke, and a multitude of other etiologies. Illustratively, we describe technique and lessons learned using DC for battlefield trauma.
Methods. Neurosurgical operative logs from service (October 2007 to September 2009) in Afghanistan that detail DC cases for trauma were analyzed. Illustrative examples of frontotemporoparietal and bifrontal DC that depict battlefield experience performing these procedures are presented with attention drawn to the L. G. Kempe hemispherectomy incision, brainstem decompression techniques, and dural onlay substitutes.
Results. Ninety craniotomies were performed for trauma over the time period analyzed. Of these, 28 (31%) were DCs. Of the 28 DCs, 24 (86%) were frontotemporoparietal DCs, 7 (25%) were bifrontal DCs, and 2 (7%) were suboccipital DCs. Decompressive craniectomies were performed for 19 penetrating head injuries (13 gunshot wounds and 6 explosions) and 9 severe closed head injuries (6 war-related explosions and 3 others).
Conclusions. Thirty-one percent of craniotomies performed for trauma were DCs. Battlefield neurosurgeons use DC to allow for safe transfer of neurologically ill patients to tertiary military hospitals, which can be located 8-18 hours from a war zone. The authors recommend the L. G. Kempe incision for blood supply preservation, large craniectomies to prevent brain strangulation over bone edges, minimal brain debridement, adequate brainstem decompression, and dural onlay substitutes for dural closure. (DOI: 10.3171/2010.3.FOCUS1028)
C1 [Ragel, Brian T.] Oregon Hlth & Sci Univ, Dept Neurol Surg, Portland, OR 97239 USA.
[Klimo, Paul, Jr.] Neurosurg Serv, Wright Patterson AFB, OH USA.
[Martin, Jonathan E.] Connecticut Childrens Med Ctr, Div Neurosurg, Hartford, CT USA.
[Teff, Richard J.] Brooke Army Med Ctr, Dept Neurosurg, Ft Sam Houston, TX 78234 USA.
[Bakken, Hans E.] Madigan Army Med Ctr, Dept Neurosurg, Ft Lewis, WA USA.
[Armonda, Rocco A.] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA.
RP Ragel, BT (reprint author), Oregon Hlth & Sci Univ, Dept Neurol Surg, Mail Code CH8N,3303 SW Bond Ave, Portland, OR 97239 USA.
EM brian.ragel@gmail.com
NR 26
TC 18
Z9 19
U1 0
U2 1
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1092-0684
J9 NEUROSURG FOCUS
JI Neurosurg. Focus
PD MAY
PY 2010
VL 28
IS 5
AR E2
DI 10.3171/2010.3.FOCUS1028
PG 10
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA 589ZU
UT WOS:000277193600002
PM 20568936
ER
PT J
AU Stephens, FL
Mossop, CM
Bell, RS
Tigno, T
Rosner, MK
Kumar, A
Moores, LE
Armonda, RA
AF Stephens, Frederick L.
Mossop, Correy M.
Bell, Randy S.
Tigno, Teodoro, Jr.
Rosner, Michael K.
Kumar, Anand
Moores, Leon E.
Armonda, Rocco A.
TI Cranioplasty complications following wartime decompressive craniectomy
SO NEUROSURGICAL FOCUS
LA English
DT Article
DE cranioplasty; craniectomy; traumatic brain injury
ID DELAYED CRANIOPLASTY; GRAFT INFECTION; TECHNICAL NOTE; BONE-GRAFTS;
SKULL BONE; EXPERIENCE
AB Object. In support of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom-Afghanistan (OEF-A), military neurosurgeons in the combat theater are faced with the daunting task of stabilizing patients in such a way as to prevent irreversible neurological injury from cerebral edema while simultaneously allowing for prolonged transport stateside (5000-7000 miles). It is in this setting that decompressive craniectomy has become a mainstay of far-forward neurosurgical management of traumatic brain injury (TBI).
As such, institutional experience with cranioplasty at the Walter Reed Army Medical Center (WRAMC) and the National Naval Medical Center (NNMC) has expanded concomitantly. Battlefield blast explosions create cavitary injury zones that often extend beyond the border of the exposed surface wound, and this situation has created unique reconstruction challenges not often seen in civilian TBI. The loss of both soft-tissue and skull base support along with the need for cranial vault reconstruction requires a multidisciplinary approach involving neurosurgery, plastics, oral-maxillofacial surgery, and ophthalmology. With this situation in mind, the authors of this paper endeavored to review the cranial reconstruction complications encountered in these combat-related injuries.
Methods. A retrospective database review was conducted for all soldiers injured in OIF and OEF-A who had undergone decompressive craniectomy with subsequent cranioplasty between April 2002 and October 2008 at the WRAMC and NNMC. During this time, both facilities received a total of 408 OIF/OEF-A patients with severe head injuries; 188 of these patients underwent decompressive craniectomies in the theater before transfer to the US. Criteria for inclusion in this study consisted of either a closed or a penetrating head injury sustained in combat operations, resulting in the performance of a decompressive craniectomy and subsequent cranioplasty at either the WRAMC or NNMC. Excluded from the study were patients for whom primary demographic data could not be verified. Demographic data, indications for craniectomy, as well as preoperative, intraoperative, and postoperative parameters following cranioplasty, were recorded. Perioperative and postoperative complications were also recorded.
Results. One hundred eight patients (male/female ratio 107: 1) met the inclusion criteria for this study, 93 with a penetrating head injury and 15 with a closed head injury. Explosive blast injury was the predominant mechanism of injury, occurring in 72 patients (67%). The average time that elapsed between injury and cranioplasty was 190 days (range 7-546 days). An overall complication rate of 24% was identified. The prevalence of perioperative infection (12%), seizure (7.4%), and extraaxial hematoma formation (7.4%) was noted. Twelve patients (11%) required prosthetic removal because of either extraaxial hematoma formation or infection. Eight of the 13 cases of infection involved cranioplasties performed between 90 and 270 days from the date of injury (p = 0.06).
Conclusions. This study represents the largest to date in which cranioplasty and its complications have been evaluated in a trauma population that underwent decompressive craniectomy. The overall complication rate of 24% is consistent with rates reported in the literature (16-34%); however, the perioperative infection rate of 12% is higher than the rates reported in other studies. This difference is likely related to aspects of the initial injury pattern-such as skull base injury, orbitofacial fractures, sinus injuries, persistent fluid collection, and CSF leakage-which can predispose these patients to infection. (DOI: 10.3171/2010.2.FOCUS1026)
C1 [Stephens, Frederick L.] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA.
Natl Naval Med Ctr, Dept Neurosurg, Bethesda, MD USA.
RP Stephens, FL (reprint author), Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA.
EM frederick.stephens@us.army.mil
NR 16
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U1 0
U2 3
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1092-0684
J9 NEUROSURG FOCUS
JI Neurosurg. Focus
PD MAY
PY 2010
VL 28
IS 5
AR E3
DI 10.3171/2010.2.FOCUS1026
PG 6
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA 589ZU
UT WOS:000277193600003
PM 20568943
ER
PT J
AU Teff, RJ
AF Teff, Richard J.
TI Use of neurosurgical decision-making and damage-control neurosurgery
courses in the Iraq and Afghanistan conflicts: a surgeon's experience
SO NEUROSURGICAL FOCUS
LA English
DT Article
DE wartime neurosurgery; penetrating brain trauma; neurosurgical decision
making; damage-control neurosurgery
AB A shortage of Coalition neurological surgeons in the Iraq conflict prompted a creative approach to standardized neurosurgical care in 2007. After formulation of theater-wide clinical pathway guidelines, a need for standardized triage and neurological resuscitation was identified. The object was to establish a simple, reproducible course for medics, forward surgical and emergency room personnel, and other critical care providers to quickly standardize the ability of all deployed health care personnel to provide state-of-the-art neurosurgical triage and damage-control interventions. The methods applied were Microsoft PowerPoint presentations and hands-on learning. The year-long project resulted in more than 100 individuals being trained in neurosurgical decision making and in more than 15 surgeons being trained in damage-control neurosurgery. At the year's conclusion, hundreds of individuals received exceptional neurosurgical care from nonneurosurgical providers and a legacy course was left for future deployed providers to receive ongoing education at their own pace. (DOI: 10.3171/2010.2.FOCUS1017)
C1 Brooke Army Med Ctr, Div Neurosurg, Ft Sam Houston, TX 78234 USA.
RP Teff, RJ (reprint author), Brooke Army Med Ctr, Div Neurosurg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM richard.teff@yahoo.com
NR 0
TC 3
Z9 3
U1 0
U2 0
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1092-0684
J9 NEUROSURG FOCUS
JI Neurosurg. Focus
PD MAY
PY 2010
VL 28
IS 5
AR E9
DI 10.3171/2010.2.FOCUS1017
PG 3
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA 589ZU
UT WOS:000277193600009
PM 20568949
ER
PT J
AU Grimme, JM
Honda, M
Wright, R
Okuno, Y
Rothenberg, E
Mazin, AV
Ha, T
Spies, M
AF Grimme, Jill M.
Honda, Masayoshi
Wright, Rebecca
Okuno, Yusuke
Rothenberg, Eli
Mazin, Alexander V.
Ha, Taekjip
Spies, Maria
TI Human Rad52 binds and wraps single-stranded DNA and mediates annealing
via two hRad52-ssDNA complexes
SO NUCLEIC ACIDS RESEARCH
LA English
DT Article
ID REPLICATION PROTEIN-A; HOMOLOGOUS RECOMBINATION; BREAK REPAIR;
SACCHAROMYCES-CEREVISIAE; YEAST RAD52; RAD51-MEDIATED RECOMBINATION;
BIOCHEMICAL-PROPERTIES; BRANCH MIGRATION; GENE; RPA
AB Rad52 promotes the annealing of complementary strands of DNA bound by replication protein A (RPA) during discrete repair pathways. Here, we used a fluorescence resonance energy transfer (FRET) between two fluorescent dyes incorporated into DNA substrates to probe the mechanism by which human Rad52 (hRad52) interacts with and mediates annealing of ssDNA-hRPA complexes. Human Rad52 bound ssDNA or ssDNA-hRPA complex in two, concentration-dependent modes. At low hRad52 concentrations, ssDNA was wrapped around the circumference of the protein ring, while at higher protein concentrations, ssDNA was stretched between multiple hRad52 rings. Annealing by hRad52 occurred most efficiently when each complementary DNA strand or each ssDNA-hRPA complex was bound by hRad52 in a wrapped configuration, suggesting homology search and annealing occur via two hRad52-ssDNA complexes. In contrast to the wild type protein, hRad52(RQK/AAA) and hRad52(1-212) mutants with impaired ability to bind hRPA protein competed with hRPA for binding to ssDNA and failed to counteract hRPA-mediated duplex destabilization highlighting the importance of hRad52-hRPA interactions in promoting efficient DNA annealing.
C1 [Grimme, Jill M.; Honda, Masayoshi; Wright, Rebecca; Okuno, Yusuke; Spies, Maria] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA.
[Grimme, Jill M.] US Army Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA.
[Rothenberg, Eli; Ha, Taekjip; Spies, Maria] Howard Hughes Med Inst, Urbana, IL 61801 USA.
[Mazin, Alexander V.] Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USA.
[Ha, Taekjip] Univ Illinois, Dept Phys, Urbana, IL 61801 USA.
[Ha, Taekjip; Spies, Maria] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA.
RP Spies, M (reprint author), Univ Illinois, Dept Biochem, Urbana, IL 61801 USA.
EM mspies@life.illinois.edu
RI Ha, Taekjip/B-9506-2009
OI Ha, Taekjip/0000-0003-2195-6258
FU University of Illinois; American Cancer Society [RSG-09-182-01-DMC];
National Science Foundation [082265]]; National Institutes of Health
[GM065367, CA100839, MH084119]; Leukemia and Lymphoma Society [1054-09];
Howard Hughes Medical Institute
FX FUNDING; University of Illinois Startup funds and American Cancer
Society [grant RSG-09-182-01-DMC to M. S.]; National Science Foundation
under [grant no. 082265]; National Institutes of Health [grant no.
GM065367 to TH]; National Institutes of Health [grants CA100839 and
MH084119]; Leukemia and Lymphoma Society Scholar Award [1054-09 to A. V.
M.]. Funding for open access charges: Howard Hughes Medical Institute.
NR 59
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Z9 39
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0305-1048
J9 NUCLEIC ACIDS RES
JI Nucleic Acids Res.
PD MAY
PY 2010
VL 38
IS 9
BP 2917
EP 2930
DI 10.1093/nar/gkp1249
PG 14
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 600NV
UT WOS:000277994600021
PM 20081207
ER
PT J
AU Roy, D
Arason, GA
Chowdhury, B
Mitra, A
Calaf, GM
AF Roy, D.
Arason, G. A.
Chowdhury, B.
Mitra, A.
Calaf, G. M.
TI Profiling of cell cycle genes of breast cells exposed to etodolac
SO ONCOLOGY REPORTS
LA English
DT Article
DE cell cycle; breast cells; etodolac
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CANCER-CELLS; EXPRESSION;
RADIATION; LINE; REPLICATION; MECHANISMS; PREVENTION; INHIBITORS;
P27(KIP1)
AB Breast cancer represents the second leading cause of cancer-related deaths in the world. There is increasing evidence that perturbation of cell cycle regulation is an important contributing factor to various cancer progression stages. There are key checkpoints in the cell cycle involving various regulatory proteins. The relationship between these cell cycle regulatory proteins and cell cycle arrest by cyclooxygenase (COX) inhibitors during neoplastic progression remains largely unknown. Preclinical studies and epidemiological investigations have consistently shown that nonsteroidal anti-inflammatory drugs have some anti-proliferative and anti-oxidative stress response on various tumors. In this study, the effect of etodolac, a 1,8-diethyl-1,3,4,9-tetrahydropyrano (3,4-beta) indole-1-acetic acid on signaling pathways was investigated by examining the differential expression of various cell cycle regulatory protein genes. A human cell cycle gene array was used to profile the expression of 96 genes involved in the cell cycle regulation. Differentially expressed genes were highly altered by etodolac treatment. Twenty-six genes were up- and 20 down-regulated with 0.5 and 2 mM etodolac treatment. respectively. Seven genes (ATM, BAX, CCNA2, CDC27, RAD50 and p21) were prominently altered, and six (ATM, CCND2, CCNF, CDC20, CDK1A and RAD50) were commonly altered with both concentrations. This finding indicated that etodolac could play a critical role on cancer cells by inducing cell death.
C1 [Roy, D.] CUNY, Dept Nat Sci, Hostos Coll, Bronx, NY 10451 USA.
[Roy, D.; Arason, G. A.] Manhattan Coll, Grad Biotechnol Program, Riverdale, NY USA.
[Chowdhury, B.] NCI, Human Retrovirus Sect, Vaccine Branch, NIH, Frederick, MD 21701 USA.
[Chowdhury, B.] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD USA.
[Mitra, A.] Coll Mt St Vincent, Dept Chem, Riverdale, NY USA.
[Calaf, G. M.] Columbia Univ, Ctr Radiol Res, Med Ctr, New York, NY 10032 USA.
[Calaf, G. M.] Univ Tarapaca, Inst Alta Invest, Arica, Chile.
RP Roy, D (reprint author), CUNY, Dept Nat Sci, Hostos Coll, Hostos Coll Campus,A-507E,475 Grand Concourse, Bronx, NY 10451 USA.
EM droy@hostos.cuny.edu
FU Manhattan College of New York
FX This study was conducted as part of a Master's Degree thesis (GAA) and
it was funded by the Graduate Biotechnology Program of the Manhattan
College of New York. Thanks are given to FONDECYT 1080482 (GMC), CUNY
Research Release Time (DR). The secretarial assistance of Danissa
Barahona is greatly appreciated. We also thank Convenio de Desempeno
UTA/MESESUP2 from Universidad de Tarapaca, Arica, Chile.
NR 43
TC 4
Z9 4
U1 3
U2 3
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1021-335X
J9 ONCOL REP
JI Oncol. Rep.
PD MAY
PY 2010
VL 23
IS 5
BP 1383
EP 1391
DI 10.3892/or_00000775
PG 9
WC Oncology
SC Oncology
GA 588MR
UT WOS:000277075100027
PM 20372855
ER
PT J
AU Huang, WL
Jain, FC
AF Huang, Wenli
Jain, Faquir C.
TI Temperature insensitivity of the threshold current density in
exciton-dominated wide energy gap quantum wire lasers
SO OPTICAL ENGINEERING
LA English
DT Article
DE quantum wire lasers; quantum dot lasers; threshold current density
temperature dependence; excitons
ID INGAN-ALGAN; SEMICONDUCTOR-LASERS; INTRABAND RELAXATION; WELL
STRUCTURES; OPTICAL GAIN; DOT LASERS; ABSORPTION; LUMINESCENCE;
TRANSITIONS; DEPENDENCE
AB We present simulations on temperature dependence of the threshold current density (J(th)) in InGaN-AlGaN and ZnCdSe-ZnMgSSe quantum wire lasers having exciton transitions. We find that J(th) in a quantum wire laser is insensitive to temperature variation when exciton binding energies are in the range of 30 to 50 meV. This behavior is similar to quantum dot lasers having free carrier transitions. We show that the temperature dependence of the threshold current density is greatly reduced in lasers having exciton transitions in comparison to the ones having free carrier transitions. The reduced dependence of J(th) on the temperature is attributed to the inherent confinement of electron-hole pairs within the exciton radius along the wire axis, whereas the quantum wire cross section provides confinement of carriers in the plane perpendicular to the wire axis. The large exciton binding energies give rise to high exciton density of states and narrow spectral line width, thus confining the carriers into a pseudoquantum dot-like structure. The effect of exciton localization due to the randomness in quantum wire fabrication, causing exciton inhomogeneous line broadening, is also discussed. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3430578]
C1 [Huang, Wenli] US Mil Acad, Photon Res Ctr, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
[Jain, Faquir C.] Univ Connecticut, Dept Elect & Comp Engn, Storrs, CT 06269 USA.
RP Huang, WL (reprint author), US Mil Acad, Photon Res Ctr, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
EM wenli.huang@usma.edu
FU ONR [N00014-02-1-0883, N00014-06-1-0016]
FX This work is supported in part by ONR contracts N00014-02-1-0883 and
N00014-06-1-0016 (Daniel Purdy, Program Director). The views expressed
in this work are those of the authors and do not reflect the official
policy or position of the United States Military Academy, the Department
of the Army, or the Department of Defense or U. S. Government.
NR 31
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Z9 1
U1 0
U2 5
PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
J9 OPT ENG
JI Opt. Eng.
PD MAY
PY 2010
VL 49
IS 5
AR 054201
DI 10.1117/1.3430578
PG 7
WC Optics
SC Optics
GA 622BB
UT WOS:000279632000017
ER
PT J
AU Qiu, LA
Goossen, KW
Heider, D
O'Brien, DJ
Wetzel, ED
AF Qiu, Liang
Goossen, Keith W.
Heider, Dirk
O'Brien, Daniel J.
Wetzel, Eric D.
TI Nonpigtail optical coupling to embedded fiber Bragg grating sensors
SO OPTICAL ENGINEERING
LA English
DT Article
DE fiber optical sensors; fiber Bragg grating; free-space coupling;
embedded optical fiber; smart structures; structural monitoring
ID MICROSENSORS; MULTIMODE; CONCRETE
AB In recent decades, optical fiber has proven useful for many sensor applications. Specifically, fiber Bragg grating (FBG) sensors have shown great utility for integrity management and environmental sensing of composite structures. One major drawback of FBG sensors, however, is the lack of a robust, nonpigtail technique for coupling to the embedded FBG sensor. In this paper, a novel method of free-space passive coupling of light into FBG sensors is described. An angled 45-deg mirror integrated directly into the fiber was used as an input coupling technique. We investigated the application of this approach to both single- and multimode glass fibers containing FBGs. For multimode FBGs, we studied the grating's uniformity across the fiber diameter and its effect on normal free-space coupling. In single- mode investigations, a novel method of coupling to the sensor via splicing a multimode fiber to a single- mode FBG (SMFBG) was developed. Finally, free-space coupling to an embedded SMFBG was employed to measure the tensile strain. Excellent agreement was found between the FBG and conventional electrical resistance strain gauges. We conclude that this coupling method might eliminate the need for pigtailing by providing a more robust coupling method for FBG sensors. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3421552]
C1 [Qiu, Liang; Goossen, Keith W.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
[Heider, Dirk] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
[O'Brien, Daniel J.; Wetzel, Eric D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Qiu, LA (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
EM qiulion@udel.edu
FU Army Research Laboratory [W911NF-06-2-011]
FX This research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement number W911NF-06-2-011. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U. S. Government. The U. S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation hereon.
NR 20
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U1 0
U2 5
PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
EI 1560-2303
J9 OPT ENG
JI Opt. Eng.
PD MAY
PY 2010
VL 49
IS 5
AR 054402
DI 10.1117/1.3421552
PG 8
WC Optics
SC Optics
GA 622BB
UT WOS:000279632000020
ER
PT J
AU Pritchett, TM
Sun, WF
Zhang, BG
Ferry, MJ
Li, YJ
Haley, JE
Mackie, DM
Shensky, W
Mott, AG
AF Pritchett, Timothy M.
Sun, Wenfang
Zhang, Bingguang
Ferry, Michael J.
Li, Yunjing
Haley, Joy E.
Mackie, David M.
Shensky, William, III
Mott, Andrew G.
TI Excited-state absorption of a bipyridyl platinum(II) complex with
alkynyl-benzothiazolylfluorene units
SO OPTICS LETTERS
LA English
DT Article
ID PHOTOPHYSICS
AB The singlet excited-state lifetime of a bipyridyl platinum(II) complex containing two alkynyl-benzothiazolylfluorene units was determined to be 145+/-105 ps by fitting femtosecond transient difference absorption data, and the triplet quantum yield was measured to be 0.14. A ground-state absorption cross section of 6.1 x 10(-19) cm(2) at 532 nm was deduced from UV-visible absorption data. Excited-state absorption cross sections of (6.7+/-0.1) x 10(-17) cm(2) (singlet) and (4.6+/-0.1) x 10(-16) cm(2) (triplet) were obtained by using a five-level dynamic model to fit open-aperture Z scans at picosecond and nanosecond pulse widths and a variety of pulse energies. For this complex, the ratio of the triplet excited-state absorption cross section to the ground-state absorption cross section-long used as a figure of merit for reverse saturable absorbers-thus stands at 754, to our knowledge the largest ever reported at 532 nm wavelength. (C) 2010 Optical Society of America
C1 [Pritchett, Timothy M.; Ferry, Michael J.; Mackie, David M.; Shensky, William, III; Mott, Andrew G.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA.
[Sun, Wenfang; Zhang, Bingguang; Li, Yunjing] N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58108 USA.
[Haley, Joy E.] USAF, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA.
[Haley, Joy E.] Universal Energy Syst Inc, Dayton, OH 45432 USA.
RP Pritchett, TM (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM timothy.pritchett1@us.army.mil
RI Shensky, William/J-7012-2014
FU Army Research Laboratory [W911NF-06-2-0032]; National Science Foundation
(NSF) [CHE-0449598]
FX W. Sun acknowledges financial support from the Army Research Laboratory
(W911NF-06-2-0032) and the National Science Foundation (NSF) (CAREER
CHE-0449598).
NR 19
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U1 0
U2 9
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
J9 OPT LETT
JI Opt. Lett.
PD MAY 1
PY 2010
VL 35
IS 9
BP 1305
EP 1307
DI 10.1364/OL.35.001305
PG 3
WC Optics
SC Optics
GA 590IU
UT WOS:000277219800001
PM 20436550
ER
PT J
AU Fridman, M
Nixon, M
Dubinskii, M
Friesem, AA
Davidson, N
AF Fridman, Moti
Nixon, Micha
Dubinskii, Mark
Friesem, Asher A.
Davidson, Nir
TI Fiber amplification of radially and azimuthally polarized laser light
SO OPTICS LETTERS
LA English
DT Article
ID BEAMS; GENERATION; MODE; PLATE
AB The results of amplifying either radially or azimuthally polarized light with a fiber amplifier are presented. Experimental results reveal that more than 85% polarization purity can be retained at the output even with 40 dB amplification and that efficient conversion of the amplified light to linear polarization can be obtained. (C) 2010 Optical Society of America
C1 [Fridman, Moti; Nixon, Micha; Friesem, Asher A.; Davidson, Nir] Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel.
[Dubinskii, Mark] USA, Res Lab, Adelphi, MD 20783 USA.
RP Fridman, M (reprint author), Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel.
EM moti.fridman@weizmann.ac.il
NR 15
TC 9
Z9 9
U1 2
U2 5
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
J9 OPT LETT
JI Opt. Lett.
PD MAY 1
PY 2010
VL 35
IS 9
BP 1332
EP 1334
DI 10.1364/OL.35.001332
PG 3
WC Optics
SC Optics
GA 590IU
UT WOS:000277219800010
PM 20436559
ER
PT J
AU Divakov, AK
Mescheryakov, YI
Zhigacheva, NI
Barakhtin, BK
Gooch, WA
AF Divakov, A. K.
Mescheryakov, Yu. I.
Zhigacheva, N. I.
Barakhtin, B. K.
Gooch, W. A.
TI Spall strength of titanium alloys
SO PHYSICAL MESOMECHANICS
LA English
DT Article
DE titanium alloys; spall strength; phase transition; microstructure; shock
loading
ID ZIRCONIUM
AB A series of high-velocity impact tests of impactors and targets of varying acoustic impedance, including Al - Ti, steel - Ti and Ti - Ti combinations, reveals a beta <->omega to phase transition in alpha+beta Ti alloys under shock loading. The presence of the omega-phase is confirmed by X-ray diffraction analysis of Ti-4.5Al-3Mo-IV alloy specimens loaded with an impactor at different impact velocities. The experiments show that at an impact velocity greater than similar to 500 m/s, spall fracture occurs earlier than the omega -> x reverse transition (where x is the alpha-phase, or the beta-phase, or their mixture) takes place during the decay of the compression pulse. Hence, the spall fracture in the material develops in the presence of the omega-phase whose dynamic strength is much smaller than that of the beta-phase. For the spall occurring after the to omega -> x reverse transition, the spall strength of the alloy increases by 25 %.
C1 [Divakov, A. K.; Mescheryakov, Yu. I.; Zhigacheva, N. I.] Inst Problems Mech Engn RAS, St Petersburg 199178, Russia.
[Barakhtin, B. K.] Cent Res Inst Struct Mat Prometey, St Petersburg 191015, Russia.
[Gooch, W. A.] USA, Res Lab, Aberdeen, MD 21005 USA.
RP Mescheryakov, YI (reprint author), Inst Problems Mech Engn RAS, St Petersburg 199178, Russia.
EM ym38@mail.ru
NR 17
TC 3
Z9 3
U1 3
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1029-9599
J9 PHYS MESOMECH
JI Phys. Mesomech.
PD MAY-AUG
PY 2010
VL 13
IS 3-4
BP 113
EP 123
DI 10.1016/j.physme.2010.07.002
PG 11
WC Mechanics; Materials Science, Characterization & Testing
SC Mechanics; Materials Science
GA 654WU
UT WOS:000282202600002
ER
PT J
AU Cruz, AR
Pillay, A
Zuluaga, AV
Ramirez, LG
Duque, JE
Aristizabal, GE
Fiel-Gan, MD
Jaramillo, R
Trujillo, R
Valencia, C
Jagodzinski, L
Cox, DL
Radolf, JD
Salazar, JC
AF Cruz, Adriana R.
Pillay, Allan
Zuluaga, Ana V.
Ramirez, Lady G.
Duque, Jorge E.
Aristizabal, Gloria E.
Fiel-Gan, Mary D.
Jaramillo, Roberto
Trujillo, Rodolfo
Valencia, Carlos
Jagodzinski, Linda
Cox, David L.
Radolf, Justin D.
Salazar, Juan C.
TI Secondary Syphilis in Cali, Colombia: New Concepts in Disease
Pathogenesis
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID PALLIDUM SUBSP PALLIDUM; VIRULENT TREPONEMA-PALLIDUM; POLYMERASE-I GENE;
OUTER-MEMBRANE; PREGNANT-WOMEN; UNITED-STATES; SOUTH-AFRICA;
RISK-FACTORS; HEPATITIS-B; WHOLE-BLOOD
AB Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia. To be eligible for participation, study subjects were required to have cutaneous lesions consistent with SS, a reactive Rapid Plasma Reagin test (RPR-titer >= 1:4), and a confirmatory treponemal test (Fluorescent Treponemal Antibody Absorption test-FTA-ABS). Most subjects enrolled were women (64.9%), predominantly Afro-Colombian (38.6%) or mestizo (56.1%), and all were of low socio-economic status. Three (5.3%) subjects were newly diagnosed with HIV infection at study entry. The duration of signs and symptoms in most patients (53.6%) was less than 30 days; however, some patients reported being symptomatic for several months (range 5-240 days). The typical palmar and plantar exanthem of SS was the most common dermal manifestation (63%), followed by diffuse hypo-or hyperpigmented macules and papules on the trunk, abdomen and extremities. Three patients had patchy alopecia. Whole blood (WB) samples and punch biopsy material from a subset of SS patients were assayed for the presence of Tp DNA polymerase I gene (polA) target by real-time qualitative and quantitative PCR methods. Twelve (46%) of the 26 WB samples studied had quantifiable Tp DNA (ranging between 194.9 and 1954.2 Tp polA copies/ml blood) and seven (64%) were positive when WB DNA was extracted within 24 hours of collection. Tp DNA was also present in 8/12 (66%) skin biopsies available for testing. Strain typing analysis was attempted in all skin and WB samples with detectable Tp DNA. Using arp repeat size analysis and tpr RFLP patterns four different strain types were identified (14d, 16d, 13d and 22a). None of the WB samples had sufficient DNA for typing. The clinical and microbiologic observations presented herein, together with recent Cali syphilis seroprevalence data, provide additional evidence that venereal syphilis is highly endemic in this region of Colombia, thus underscoring the need for health care providers in the region to be acutely aware of the clinical manifestations of SS. This study also provides, for the first time, quantitative evidence that a significant proportion of untreated SS patients have substantial numbers of circulating spirochetes. How Tp is able to persist in the blood and skin of SS patients, despite the known presence of circulating treponemal opsonizing antibodies and the robust pro-inflammatory cellular immune responses characteristic of this stage of the disease, is not fully understood and requires further study.
C1 [Cruz, Adriana R.; Zuluaga, Ana V.; Ramirez, Lady G.; Duque, Jorge E.; Trujillo, Rodolfo; Valencia, Carlos] CIDEIM, Cali, Colombia.
[Pillay, Allan; Cox, David L.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Aristizabal, Gloria E.] Secretaria Salud Publ Municipal, Cali, Colombia.
[Fiel-Gan, Mary D.] Hartford Hosp, Dept Pathol, Hartford, CT 06115 USA.
[Jaramillo, Roberto] Fdn Clin Valle del Lili, Cali, Colombia.
[Jagodzinski, Linda] Walter Reed Army Inst Res, Rockville, MD USA.
[Radolf, Justin D.] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT USA.
[Radolf, Justin D.] Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT USA.
[Salazar, Juan C.] Univ Connecticut, Ctr Hlth, Dept Pediat, Farmington, CT USA.
[Salazar, Juan C.] Connecticut Childrens Med Ctr, Div Infect Dis, Hartford, CT USA.
RP Cruz, AR (reprint author), CIDEIM, Cali, Colombia.
EM jsalaza@ccmckids.org
FU Public Health Service [K23 AI62439, 5R03TW008023, AI-26756, AI-38894];
Connecticut Children's Medical Center (CCMC); COLCIENCIAS [222940820554]
FX This work was supported in part by Public Health Service grants K23
AI62439 (JCS), 5R03TW008023 (JCS and AC), AI-26756 (JR), AI-38894 (JR),
Connecticut Children's Medical Center's (CCMC) Arrison and Burr Curtis
Research Funds (JCS) and COLCIENCIAS grant # 222940820554 (AC). The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 78
TC 21
Z9 23
U1 1
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAY
PY 2010
VL 4
IS 5
AR e690
DI 10.1371/journal.pntd.0000690
PG 13
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 608QO
UT WOS:000278601000020
PM 20502522
ER
PT J
AU Hensley, LE
Mulangu, S
Asiedu, C
Johnson, J
Honko, AN
Stanley, D
Fabozzi, G
Nichol, ST
Ksiazek, TG
Rollin, PE
Wahl-Jensen, V
Bailey, M
Jahrling, PB
Roederer, M
Koup, RA
Sullivan, NJ
AF Hensley, Lisa E.
Mulangu, Sabue
Asiedu, Clement
Johnson, Joshua
Honko, Anna N.
Stanley, Daphne
Fabozzi, Giulia
Nichol, Stuart T.
Ksiazek, Thomas G.
Rollin, Pierre E.
Wahl-Jensen, Victoria
Bailey, Michael
Jahrling, Peter B.
Roederer, Mario
Koup, Richard A.
Sullivan, Nancy J.
TI Demonstration of Cross-Protective Vaccine Immunity against an Emerging
Pathogenic Ebolavirus Species
SO PLOS PATHOGENS
LA English
DT Article
ID NONHUMAN-PRIMATES; RHESUS-MONKEYS; HEMORRHAGIC-FEVER; VIRUS INFECTION;
CELL RESPONSES; T-LYMPHOCYTES; REPLICATION; VECTORS; GLYCOPROTEIN;
GENERATION
AB A major challenge in developing vaccines for emerging pathogens is their continued evolution and ability to escape human immunity. Therefore, an important goal of vaccine research is to advance vaccine candidates with sufficient breadth to respond to new outbreaks of previously undetected viruses. Ebolavirus (EBOV) vaccines have demonstrated protection against EBOV infection in nonhuman primates (NHP) and show promise in human clinical trials but immune protection occurs only with vaccines whose antigens are matched to the infectious challenge species. A 2007 hemorrhagic fever outbreak in Uganda demonstrated the existence of a new EBOV species, Bundibugyo (BEBOV), that differed from viruses covered by current vaccine candidates by up to 43% in genome sequence. To address the question of whether cross-protective immunity can be generated against this novel species, cynomolgus macaques were immunized with DNA/rAd5 vaccines expressing ZEBOV and SEBOV glycoprotein (GP) prior to lethal challenge with BEBOV. Vaccinated subjects developed robust, antigen-specific humoral and cellular immune responses against the GP from ZEBOV as well as cellular immunity against BEBOV GP, and immunized macaques were uniformly protected against lethal challenge with BEBOV. This report provides the first demonstration of vaccine-induced protective immunity against challenge with a heterologous EBOV species, and shows that Ebola vaccines capable of eliciting potent cellular immunity may provide the best strategy for eliciting cross-protection against newly emerging heterologous EBOV species.
C1 [Hensley, Lisa E.; Johnson, Joshua; Honko, Anna N.; Wahl-Jensen, Victoria] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Mulangu, Sabue; Asiedu, Clement; Stanley, Daphne; Fabozzi, Giulia; Bailey, Michael; Sullivan, Nancy J.] NIAID, Biodef Res Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Nichol, Stuart T.; Ksiazek, Thomas G.; Rollin, Pierre E.] Ctr Dis Control & Prevent, Special Pathogens Branch, Div Viral & Rickettsial Dis, Atlanta, GA USA.
[Jahrling, Peter B.] NIAID, Integrated Res Facil, NIH, Bethesda, MD 20892 USA.
[Roederer, Mario; Koup, Richard A.] NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
RP Hensley, LE (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
EM nsullivan@nih.gov
OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X
FU Vaccine Research Center, NIAID, National Institutes of Health
FX This work was supported in part by the Intramural Research Program of
the Vaccine Research Center, NIAID, National Institutes of Health. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 34
TC 60
Z9 62
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1553-7366
J9 PLOS PATHOG
JI PLoS Pathog.
PD MAY
PY 2010
VL 6
IS 5
AR e1000904
DI 10.1371/journal.ppat.1000904
PG 9
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA 610TL
UT WOS:000278759900023
PM 20502688
ER
PT J
AU Song, H
Hwang, J
Yi, H
Ulrich, RL
Yu, Y
Nierman, WC
Kim, HS
AF Song, Han
Hwang, Junghyun
Yi, Hyojeong
Ulrich, Ricky L.
Yu, Yan
Nierman, William C.
Kim, Heenam Stanley
TI The Early Stage of Bacterial Genome-Reductive Evolution in the Host
SO PLOS PATHOGENS
LA English
DT Article
ID MICROBIAL GENE IDENTIFICATION; BURKHOLDERIA-PSEUDOMALLEI; CAUSATIVE
AGENT; ALPHA-PROTEOBACTERIA; MALLEI; SEQUENCE; MELIOIDOSIS; EXPRESSION;
STRATEGIES; GLANDERS
AB The equine-associated obligate pathogen Burkholderia mallei was developed by reductive evolution involving a substantial portion of the genome from Burkholderia pseudomallei, a free-living opportunistic pathogen. With its short history of divergence (similar to 3.5 myr), B. mallei provides an excellent resource to study the early steps in bacterial genome reductive evolution in the host. By examining 20 genomes of B. mallei and B. pseudomallei, we found that stepwise massive expansion of IS (insertion sequence) elements ISBma1, ISBma2, and IS407A occurred during the evolution of B. mallei. Each element proliferated through the sites where its target selection preference was met. Then, ISBma1 and ISBma2 contributed to the further spread of IS407A by providing secondary insertion sites. This spread increased genomic deletions and rearrangements, which were predominantly mediated by IS407A. There were also nucleotide-level disruptions in a large number of genes. However, no significant signs of erosion were yet noted in these genes. Intriguingly, all these genomic modifications did not seriously alter the gene expression patterns inherited from B. pseudomallei. This efficient and elaborate genomic transition was enabled largely through the formation of the highly flexible IS-blended genome and the guidance by selective forces in the host. The detailed IS intervention, unveiled for the first time in this study, may represent the key component of a general mechanism for early bacterial evolution in the host.
C1 [Song, Han; Hwang, Junghyun; Yi, Hyojeong; Kim, Heenam Stanley] Korea Univ, Coll Med, Dept Med, Seoul 136705, South Korea.
[Ulrich, Ricky L.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Yu, Yan; Nierman, William C.] J Craig Venter Inst, Rockville, MD USA.
[Nierman, William C.] George Washington Univ, Sch Med, Dept Biochem & Mol Biol, Washington, DC USA.
RP Kim, HS (reprint author), Korea Univ, Coll Med, Dept Med, Seoul 136705, South Korea.
EM hstanleykim@korea.ac.kr
FU Ministry of Education, Science & Technology in the Republic of Korea
[2009K000516, 20090058514, K20601000002-09E0100-00210]; National
Institute of Allergy and Infectious Diseases, National Institutes of
Health, Department of Health and Human Services [NIAID N01-AI30071]
FX This work was supported by grants 2009K000516 from the 21C Frontier
Microbial Genomics & Applications Center Program, 20090058514 from the
Basic Research Program, and the K20601000002-09E0100-00210 from the
Korea Foundation for International Cooperation of Science & Technology
(KICOS), all of which are from the Ministry of Education, Science &
Technology in the Republic of Korea to HSK. Sequencing and annotation of
most of the Bp and Bm strains was supported in whole or part with
federal funds from the National Institute of Allergy and Infectious
Diseases, National Institutes of Health, Department of Health and Human
Services under contract number NIAID N01-AI30071. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 44
TC 42
Z9 42
U1 1
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1553-7366
J9 PLOS PATHOG
JI PLoS Pathog.
PD MAY
PY 2010
VL 6
IS 5
AR e1000922
DI 10.1371/journal.ppat.1000922
PG 10
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA 610TL
UT WOS:000278759900041
PM 20523904
ER
PT J
AU Weeks, SR
McAuliffe, CL
DuRussel, D
Pasquina, PF
AF Weeks, Sharon R.
McAuliffe, Caitlin L.
DuRussel, David
Pasquina, Paul F.
TI Physiological and Psychological Fatigue in Extreme Conditions: The
Military Example
SO PM&R
LA English
DT Article
AB The extreme conditions causing fatigue in military service members in combat and combat training deserve special consideration. The collective effects of severe exertion, limited caloric intake, and sleep deprivation, combined with the inherent stressors of combat, lead to both physiological and psychological fatigue that may significantly impair performance. Studies of combat training have revealed a myriad of endocrine, cognitive, and neurological changes that occur as a result of exposure to extreme conditions. Further contributory effects of multiple military deployments, post-traumatic stress disorder, and traumatic brain injury may also influence both the susceptibility to and expression of fatigue states. Further research is needed to explore these effects to enhance military readiness and performance as well as prevent injuries. PM R 2010;2:438-441
C1 [Weeks, Sharon R.; McAuliffe, Caitlin L.; DuRussel, David; Pasquina, Paul F.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA.
RP Pasquina, PF (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM paul.pasquina@us.army.mil
OI Weeks, Sharon/0000-0002-9952-9136
FU Military Amputee Research Program; Center for Neuroscience and
Regenerative Medicine; Center for Neuroscience and Regenerative Medicine
(CNRM) at the Uniformed Services University of the Health Sciences
FX Funded by the Military Amputee Research Program; Funded by the Center
for Neuroscience and Regenerative Medicine; The views expressed in this
article are those of the authors and do not reflect the official policy
of the Department of the Army, Department of Defense, or the United
States Government. The authors would also like to acknowledge the
support of the Center for Neuroscience and Regenerative Medicine (CNRM)
at the Uniformed Services University of the Health Sciences
NR 29
TC 9
Z9 10
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1934-1482
J9 PM&R
JI PM&R
PD MAY
PY 2010
VL 2
IS 5
BP 438
EP 441
DI 10.1016/j.pmrj.2010.03.023
PG 4
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA V23SB
UT WOS:000208361400015
PM 20656625
ER
PT J
AU Vizzard, JW
Capron, TA
AF Vizzard, James W.
Capron, Timothy A.
TI Exporting General Petraeus's Counterinsurgency Doctrine: An Assessment
of the Adequacy of Field Manual 3-24 and the US Government's
Implementation
SO PUBLIC ADMINISTRATION REVIEW
LA English
DT Article
AB The authors review the U.S. Army's field manual on counterinsurgency, consider the doctrine and tactics that it espouses, and survey its current critics. They present specific examples of its application and conclude that while counterinsurgency does achieve results, the U. S. government lacks a strategic doctrinal framework for implementing counterinsurgency elsewhere. This shortcoming urgently needs to be addressed in a meaningful way by political leaders.
C1 [Vizzard, James W.] USA, Washington, DC 20310 USA.
[Capron, Timothy A.] Calif State Univ Sacramento, Sacramento, CA 95819 USA.
RP Vizzard, JW (reprint author), USA, Washington, DC 20310 USA.
EM james.vizzard@gmail.com; capron@csus.edu
NR 17
TC 1
Z9 1
U1 1
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0033-3352
J9 PUBLIC ADMIN REV
JI Public Adm. Rev.
PD MAY-JUN
PY 2010
VL 70
IS 3
BP 485
EP 493
PG 9
WC Public Administration
SC Public Administration
GA 588OU
UT WOS:000277082500014
ER
PT J
AU Collen, J
Greenburg, D
Holley, A
King, C
Roop, S
Hnatiuk, O
AF Collen, Jacob
Greenburg, David
Holley, Aaron
King, Christopher
Roop, Stuart
Hnatiuk, Oleh
TI Racial discordance in spirometry comparing four commonly used reference
equations to the National Health and Nutrition Examination Study III
SO RESPIRATORY MEDICINE
LA English
DT Article
DE Spirometry; African-American; Discordance; Pulmonary function test
ID FORCED EXPIRATORY VOLUME; REFERENCE VALUES; LUNG-FUNCTION; VITAL
CAPACITY; UNITED-STATES; AFRICAN; MANAGEMENT; ADULTS
AB Diagnosing lung function abnormalities requires application of the appropriate reference equation for a given patient population. Current guidelines recommend the National Health and Examination Study III data set for evaluating patients in the United States. In Caucasian patients, relying on older reference equations, as opposed to those derived from the NHANES Ill data set, will often result in a different interpretation of a patient's spirometry. The present study assessed whether similar discordance would occur in African-American patients.
A cross-sectional analysis of African-American patients undergoing spirometry testing at our hospital was performed. Patients were classified as normal, restricted, obstructed or mixed based upon the ATS/ERS guidelines, using Crapo, Knudson, Morris, Glindmeyer, and NHANES III prediction equations. Differences in classification were evaluated.
4463 subjects were identified, with a mean age of 49.6. Discordance in interpretation was most common when results from prediction equations by Morris, Knudson, and Glindmeyer were compared to NHANES III (24.6%, 26.4%, and 20.1%, respectively). Discordance was less common when comparing Crapo to NHANES III (12.8%). There was a tendency for Knudson, Morris and Glindmeyer to under classify restriction, and for Crapo, Morris, and Glindmeyer to over classify obstruction.
There is significant discordance in interpretation when spirometry for African-American patients is referenced to equations published by Crapo, Morris, Knudson, and Glindmeyer, compared to NHANES III. Published by Elsevier Ltd.
C1 [Collen, Jacob; Holley, Aaron; King, Christopher; Roop, Stuart] USA, Walter Reed Army Med Ctr, Washington, DC 20310 USA.
[Greenburg, David] USA, Madigan Army Med Ctr, Tacoma, WA USA.
[Hnatiuk, Oleh] NIH, Bethesda, MD 20892 USA.
RP Collen, J (reprint author), USA, Walter Reed Army Med Ctr, Washington, DC 20310 USA.
EM jacob.collen@amedd.army.mil; dgreenburg@usuhs.mil;
aaron.holley@amedd.army.mil; christopher.king@amedd.army.mil;
stuart.roop@amedd.army.mil; hnatiuko@nhlbi.nih.gov
NR 31
TC 2
Z9 2
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0954-6111
J9 RESP MED
JI Respir. Med.
PD MAY
PY 2010
VL 104
IS 5
BP 705
EP 711
DI 10.1016/j.rmed.2009.11.001
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System
SC Cardiovascular System & Cardiology; Respiratory System
GA 604MD
UT WOS:000278282200012
PM 19931442
ER
PT J
AU Nurenberg, JR
Schleifer, SJ
Vijayalakshmy, P
AF Nurenberg, Jeffry R.
Schleifer, Steven J.
Vijayalakshmy, Patrick
TI Curtailing antipsychotic polypharmacy in a state institution: review and
update of a performance improvement intervention
SO SALUD I CIENCIA
LA Spanish
DT Article
DE antipsychotic polypharmacy; state psychiatric hospital; intervention;
restriction
AB A moderate intensity performance improvement initiative at a state psychiatric hospital to reduce antipsychotic polypharmacy was undertaken in November 2001. The Chief of Psychiatry met with each of 14 psychiatrists, comparing their rates of polypharmacy with that of their peers, and asked all to attempt a 10% decrease in antipsychotic polypharmacy. Polypharmacy fell significantly from 40 percent of patients treated with antipsychotics in November 2001 to 31 percent in August 2002. Reduced polypharmacy was not related to baseline rates or associated with increased use of other psychotropic medications. Rates of polypharmacy in 2006-2008 appear to have reverted to the 40% range, however. During a period of institutional change, possibly associated with increased clinical acuity, antipsychotic polypharmacy approached 67%. While an only modestly intensive intervention by leadership appeared to reduce polypharmacy in 2001, studies are required to determine whether such efforts can be efficacious under different more acute clinical conditions.
C1 [Nurenberg, Jeffry R.] Psychiat Greystone Pk Psychiat Hosp, Newark, NJ USA.
[Nurenberg, Jeffry R.; Schleifer, Steven J.] Univ Med & Dent New Jersey, Newark, NJ 07103 USA.
[Vijayalakshmy, Patrick] Brooke Army Med Ctr, San Antonio, TX USA.
RP Nurenberg, JR (reprint author), Greystone Pk Psychiat Hosp, Morris Plains, NJ 07950 USA.
EM Jeffry.Nurenberg@dhs.state.nj.us
NR 2
TC 0
Z9 0
U1 0
U2 0
PU SOC IBEROAMERICANA INFORMACION CIENTIFICA-S I I C
PI BUENOS AIRES
PA AVE BELGRANO 430-C1092AAR, BUENOS AIRES, 00000, ARGENTINA
SN 1667-8982
J9 SALUD CIENC
JI Salud Cienc.
PD MAY
PY 2010
VL 17
IS 5
BP 432
EP 434
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 694NV
UT WOS:000285305800006
ER
PT J
AU Sturm, M
AF Sturm, Matthew
TI Arctic Plants Feel the Heat
SO SCIENTIFIC AMERICAN
LA English
DT Article
ID ALASKA
C1 USA, Washington, DC 20310 USA.
RP Sturm, M (reprint author), USA, Washington, DC 20310 USA.
NR 5
TC 4
Z9 5
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0036-8733
J9 SCI AM
JI Sci.Am.
PD MAY
PY 2010
VL 302
IS 5
BP 66
EP 73
DI 10.1038/scientificamerican0510-66
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 586QJ
UT WOS:000276926100026
PM 20443380
ER
PT J
AU Wang, Y
Chen, LQ
Liu, ZK
Mathaudhu, SN
AF Wang, Y.
Chen, L. -Q.
Liu, Z. -K.
Mathaudhu, S. N.
TI First-principles calculations of twin-boundary and stacking-fault
energies in magnesium
SO SCRIPTA MATERIALIA
LA English
DT Article
DE Magnesium; Interfaces; Twinning; First-principles calculation
ID HCP METALS; PSEUDOPOTENTIALS
AB The interfacial energies of twin boundaries and stacking faults in metal magnesium have been calculated using first-principles supercell approach. Four types of twin boundaries and two types of stacking faults are investigated, namely, those due to the (10 (1) over bar1) mirror reflection, the (10 (1) over bar1) mirror glide, the (10 (1) over bar2) mirror reflection, the (10 (1) over bar2) mirror glide, the I1 stacking fault and the I2 stacking fault. The effects of supercell size on the calculated interfacial energies are examined. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Wang, Y.; Chen, L. -Q.; Liu, Z. -K.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Mathaudhu, S. N.] USA, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Wang, Y (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
EM yuw3@psu.edu
RI Mathaudhu, Suveen/B-4192-2009; Chen, LongQing/I-7536-2012; Wang,
Yi/D-1032-2013; Liu, Zi-Kui/A-8196-2009
OI Chen, LongQing/0000-0003-3359-3781; Liu, Zi-Kui/0000-0003-3346-3696
FU U.S. Army Research Laboratory [W911NF-08-2-0064]; Office of Science of
the U.S. Department of Energy [DE-AC02-05CH11231]; National Science
Foundation [DMR-9983532, DMR-0122638, DMR-0205232, DMR-0510180];
Materials Simulation Center; Graduate Education and Research Services at
the Pennsylvania State University
FX The financial support from U.S. Army Research Laboratory under Contract
W911NF-08-2-0064 is especially acknowledged. This research used
resources of the National Energy Research Scientific Computing Center,
which is supported by the Office of Science of the U.S. Department of
Energy under Contract No. DE-AC02-05CH11231. Calculations were also
conducted at the LION clusters at the Pennsylvania State University
(supported in part by National Science Foundation Grants Nos.
DMR-9983532, DMR-0122638, and DMR-0205232, and in part by the Materials
Simulation Center and the Graduate Education and Research Services at
the Pennsylvania State University). Additional funding from the National
Science Foundation through Grant DMR-0510180 is gratefully acknowledged.
The views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the U.S. Army Research
Laboratory or the U.S. Government. The U.S. Government is authorized to
reproduce and distributed reprints for Government purposes not
withstanding any copyright notation hereon.
NR 21
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6462
J9 SCRIPTA MATER
JI Scr. Mater.
PD MAY
PY 2010
VL 62
IS 9
BP 646
EP 649
DI 10.1016/j.scriptamat.2010.01.014
PG 4
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA 573SA
UT WOS:000275933700004
ER
PT J
AU Berman, OL
Gumbs, G
Folkes, PA
AF Berman, Oleg L.
Gumbs, Godfrey
Folkes, Patrick A.
TI Collective properties of excitons in the presence of a two-dimensional
electron gas
SO SOLID STATE COMMUNICATIONS
LA English
DT Article
DE Quantum wells; Semiconductors; Electron-electron interactions; Phase
transitions
ID COUPLED QUANTUM-WELLS; PHASE-TRANSITIONS; GROUND-STATE; SYSTEMS;
CONDENSATION; HOLE; PHOTOLUMINESCENCE; ENERGY
AB We have studied the collective properties of two-dimensional (2D) excitons immersed within a quantum well which contains 2D excitons and a two-dimensional electron gas (2DEG). We have also analyzed the excitations for a system of 2D dipole excitons with spatially separated electrons and holes in a pair of quantum wells (CQWs) when one of the wells contains a 2DEG Calculations of the superfluid density and the Kosterlitz-Thouless (K-T) phase transition temperature for the 2DEG-exciton system in a quantum well have shown that the K-T transition temperature increase with increasing exciton density and that it might be possible to have fast long-range transport of excitons The superfluid density and the K-T transition temperature for dipole excitons in CQWs in the presence of a 2DEG in one of the wells Increases with increasing inter-well separation. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Berman, Oleg L.] CUNY, New York City Coll Technol, Dept Phys, Brooklyn, NY 11201 USA.
[Gumbs, Godfrey] CUNY Hunter Coll, Dept Phys & Astron, New York, NY 10065 USA.
[Folkes, Patrick A.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Berman, OL (reprint author), CUNY, New York City Coll Technol, Dept Phys, 300 Jay St, Brooklyn, NY 11201 USA.
FU PSC CUNY [621360040]; AFRL [FA9453-07-C-0207]
FX O.L.B. would like to acknowledge the support by PSC CUNY grant 621360040
GG would like to acknowledge the support by contract FA9453-07-C-0207 of
AFRL
NR 31
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U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0038-1098
J9 SOLID STATE COMMUN
JI Solid State Commun.
PD MAY
PY 2010
VL 150
IS 17-18
BP 832
EP 835
DI 10.1016/j.ssc.2010.02.012
PG 4
WC Physics, Condensed Matter
SC Physics
GA 584VM
UT WOS:000276781600007
ER
PT J
AU Fonda, SJ
Kedziora, RJ
Vigersky, RA
Bursell, SE
AF Fonda, Stephanie J.
Kedziora, Richard J.
Vigersky, Robert A.
Bursell, Sven-Erik
TI Combining iGoogle and Personal Health Records to Create a Prototype
Personal Health Application for Diabetes Self-Management
SO TELEMEDICINE JOURNAL AND E-HEALTH
LA English
DT Article
DE e-health; technology; medical records
ID RANDOMIZED CONTROLLED-TRIAL; GLUCOSE MONITORING-SYSTEM; QUALITATIVE
RESEARCH; ETHNICALLY DIVERSE; IDEATEL PROJECT; CARE; USABILITY;
INTERNET; IMPLEMENTATION; INFORMATICS
AB Objective: The aim of this project is to create a prototype for a personal health application (PHA) for patients (i.e., consumers) with diabetes by employing a user-centered design process. This article describes the design process for and resulting architecture, workflow, and functionality of such a PHA. Materials and Methods: For the design process, we conducted focus groups with people who have diabetes (n=21) to ascertain their needs for a PHA. We then developed a prototype in response to these needs, and through additional focus groups and step-by-step demonstrations for people with diabetes as well as healthcare providers, we obtained feedback about the prototype. The feedback led to changes in the PHA's presentation and function. Results: Focus group participants said they wanted a tool that could give them timely, readily available information on how diabetes-related domains interact, how their behaviors affect them, and what to do next. Thus, the prototype PHA is Internet-based, retrieves data for diabetes self-management from a personal health record, displays those data using gadgets in the consumer's iGoogle page, and makes the data available to a decision-support component that provides lifestyle-oriented advice. Manipulation of the data enables consumers to anticipate the results of future actions and to see interrelationships. Conclusions: A user-centered design process resulted in a PHA that uses technology that is publicly available, employs a personal health record, and is Internet based. This PHA can provide the backbone for a decision support system that can bring together the cornerstones of diabetes self-management and integrate them into the life of the person with diabetes.
C1 [Fonda, Stephanie J.; Vigersky, Robert A.] Walter Reed Army Med Ctr, Dept Med, Serv Endocrinol, Washington, DC 20307 USA.
[Kedziora, Richard J.] Estenda Solut Inc, Conshohocken, PA USA.
[Bursell, Sven-Erik] Univ Hawaii, John A Burns Sch Med, Telehlth Res Inst, Honolulu, HI 96822 USA.
RP Fonda, SJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Serv Endocrinol, 6900 Georgia Ave NW,Bldg 2,Room 7D, Washington, DC 20307 USA.
EM fondasj@gmail.com
FU Robert Wood Johnson Foundation [59888, 63415, 64533]; California
HealthCare Foundation
FX This work was supported by grant 59888 (to S.J.F. and S.-E.B.) and
grants 63415 and 64533 (to S.J.F.) from the Robert Wood Johnson
Foundation and the California HealthCare Foundation.
NR 32
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U1 2
U2 14
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-5627
J9 TELEMED J E-HEALTH
JI Telemed. J. e-Health
PD MAY
PY 2010
VL 16
IS 4
BP 480
EP 489
DI 10.1089/tmj.2009.0122
PG 10
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA 601ZI
UT WOS:000278107000049
PM 20455776
ER
PT J
AU Lebeda, FJ
Cer, RZ
Mudunuri, U
Stephens, R
Singh, BR
Adler, M
AF Lebeda, Frank J.
Cer, Regina Z.
Mudunuri, Uma
Stephens, Robert
Singh, Bal Ram
Adler, Michael
TI The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins
SO TOXINS
LA English
DT Review
DE catalysis; energy; k(cat); K-m; superactivation
AB The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are the causative agents of botulism. Following exposure, the neurotoxin binds and enters peripheral cholinergic nerve endings and specifically and selectively cleaves one or more SNARE proteins to produce flaccid paralysis. This review centers on the kinetics of the Zn-dependent proteolytic activities of these neurotoxins, and briefly describes inhibitors, activators and factors underlying persistence of toxin action. Some of the structural, enzymatic and inhibitor data that are discussed here are available at the botulinum neurotoxin resource, BotDB (http://botdb.abcc.ncifcrf.gov).
C1 [Lebeda, Frank J.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Cer, Regina Z.; Mudunuri, Uma; Stephens, Robert] NCI Frederick, Bioinformat Support Grp, Adv Biomed Comp Ctr, Informat Syst Program,SAIC Frederick Inc, Ft Detrick, MD 21702 USA.
[Singh, Bal Ram] Univ Massachusetts, Botulinum Res Ctr, Dartmouth, MA 02747 USA.
[Adler, Michael] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Lebeda, FJ (reprint author), USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
EM frank.lebeda@amedd.army.mil; cerr@mail.nih.gov; mudunuriu@mail.nih.gov;
stephensr@mail.nih.gov; bsingh@umassd.edu; michael.adler@us.army.mil
FU Defense Threat Reduction Agency, Joint Science and Technology
Office-Chemical Biological Defense [3.10043-07-RD-B, T.T.0011-06-RC_B];
National Cancer Institute, National Institutes of Health
[HHSN261200800001E]
FX This study was supported by the Defense Threat Reduction Agency, Joint
Science and Technology Office-Chemical Biological Defense project
3.10043-07-RD-B (FJL), and project T.T.0011-06-RC_B (MA) and by the
National Cancer Institute, National Institutes of Health under contract
HHSN261200800001E. Opinions, interpretations, conclusions, and
recommendations are those of the authors and are not necessarily
endorsed by the U. S. Army or the Department of Health and Human
Services. The mention of trade names, commercial products, or
organizations does not imply endorsement by the U. S. Government.
Electronic versions for some of the citations used in the analysis for
this paper were obtained at the National Library of Medicine, the
Uniform Services University of the Health Sciences and the Sheridan
Libraries at Johns Hopkins University.
NR 100
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U1 1
U2 11
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6651
J9 TOXINS
JI Toxins
PD MAY
PY 2010
VL 2
IS 5
BP 978
EP 997
DI 10.3390/toxins2050978
PG 20
WC Toxicology
SC Toxicology
GA V24UI
UT WOS:000208434900004
PM 22069621
ER
PT J
AU Deters, KA
Brown, RS
Carter, KM
Boyd, JW
Eppard, MB
Seaburg, AG
AF Deters, Katherine A.
Brown, Richard S.
Carter, Kathleen M.
Boyd, James W.
Eppard, M. Brad
Seaburg, Adam G.
TI Performance Assessment of Suture Type, Water Temperature, and Surgeon
Skill in Juvenile Chinook Salmon Surgically Implanted with Acoustic
Transmitters
SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY
LA English
DT Article
ID TELEMETRY TRANSMITTERS; SWIMMING PERFORMANCE; ATLANTIC SALMON;
RAINBOW-TROUT; GROWTH; MORTALITY; SURVIVAL; FISH; WILD
AB This study assessed performance of seven suture types in subyearling Chinook salmon Oncorhynchus tshawytscha implanted with acoustic microtransmitters and held at two water temperatures (12 degrees C and 17 degrees C). Nonabsorbable (Ethilon) and absorbable (Monocryl) monofilament sutures and nonabsorbable (Nurolon and silk) and absorbable (Vicryl, Vicryl Plus, and Vicryl Rapide) braided sutures were used to close incisions in Chinook salmon. When differences existed among suture types, tag and suture retention were generally highest for monofilament sutures. Wound inflammation and ulceration were generally lower for Ethilon and Monocryl than for most of the braided sutures. In this study, Nurolon (braided) often resulted in low wound inflammation and ulceration, although suture retention was poor. Generally, fish held in 12 degrees C water had more desirable postsurgery healing characteristics (i.e., higher tag and suture retention; lower incision openness, wound inflammation, and ulceration) at 7 and 14 d postsurgery than fish held in 17 degrees C water. On days 34 and 63, tag retention remained high among fish in 12 degrees C water, while suture retention decreased dramatically in both water temperatures. We found a significant effect of surgeon on tag and suture retention, wound inflammation and ulceration, and incision openness. Surgeons in this study were initially thought to have similar surgical proficiency based on their extensive previous experience. However, surgeons who had received feedback on their previous surgical technique performed better in this study. Results indicate that surgical training (i.e., feedback) and perhaps aptitude, rather than surgeon experience alone, may be as important as suture type in influencing the retention of sutures and tags. The overall results support the conclusion that Monocryl is the best suture material for closing incisions created during surgical implantation of acoustic microtransmitters in subyearling Chinook salmon. Future research should include testing different suturing patterns and knotting techniques as well as the number of knots required for different incision lengths.
C1 [Deters, Katherine A.; Brown, Richard S.; Carter, Kathleen M.; Boyd, James W.] Pacific NW Natl Lab, Richland, WA 99352 USA.
[Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97204 USA.
[Seaburg, Adam G.] Univ Washington, Columbia Basin Res, Sch Aquat & Fishery Sci, Seattle, WA 98101 USA.
RP Deters, KA (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99352 USA.
EM katherine.deters@pnl.gov
NR 23
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U1 1
U2 8
PU AMER FISHERIES SOC
PI BETHESDA
PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA
SN 0002-8487
J9 T AM FISH SOC
JI Trans. Am. Fish. Soc.
PD MAY
PY 2010
VL 139
IS 3
BP 888
EP 899
DI 10.1577/T09-043.1
PG 12
WC Fisheries
SC Fisheries
GA 595UQ
UT WOS:000277639200022
ER
PT J
AU Serkin, FB
Soderdahl, DW
Cullen, J
Chen, YM
Hernandez, J
AF Serkin, Faye B.
Soderdahl, Douglas W.
Cullen, Jennifer
Chen, Yongmei
Hernandez, Javier
TI Patient risk stratification using Gleason score concordance and
upgrading among men with prostate biopsy Gleason score 6 or 7
SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
LA English
DT Article; Proceedings Paper
CT 3rd Annual Bladder Cancer Think Tank
CY AUG, 2008
CL Mont Tremblant, CANADA
DE Prostate cancer; Gleason sum; Discordance; Survival
ID RADICAL PROSTATECTOMY; NEEDLE-BIOPSY; CANCER; ANTIGEN; DISCREPANCIES;
SPECIMENS; ACCURACY; FEATURES; VOLUME; GRADE
AB Purpose: To define the impact of discordant Gleason sum (GS) between prostate biopsy (Pbx) tissue and radical prostatectomy (RP) specimen among men initially diagnosed with Gleason 6 or 7 prostate adenocarcinoma.
Materials and methods: We evaluated patients diagnosed with GS 6 or 7 and treated primarily with RP. We defined the frequency of GS discordance between Pbx and RP pathology reports. We analyzed pretreatment parameters associated with GS discordance and compared immediate postprostatectomy outcome variables across patient groups defined by their GS and concordance. We then conducted survival analysis for biochemical recurrence across patient groups defined by their GS and concordance status.
Results: Among patients with GS 6 on Pbx, 681/1,847 (36.86%) patients were upgraded to GS 7 or higher after RP. Surgical margin, capsular involvement, seminal vesicle, and nodal involvement status were more favorable in patients with concordant Pbx and RP specimen with GS 6 (P < 0.0001). Patients with smaller transrectal ultrasound (TRUS) prostate volume were found to have higher PSA densities and were more likely to be upgraded at RP. Multivariate survival analysis also predicted fewer biochemical recurrence events over time in men with concordant Pbx tissue and RP specimen of GS 6 vs. 6/7 or 7/7 (P = 0.0025) controlling for other relevant covariates.
Conclusions: GS discordance between Pbx tissue and RP specimens among prostate cancer patients initially diagnosed with either GS 6 or 7 adenocarcinoma of the prostate is substantial. This discordance has potential clinical significance in predicting oncologic outcomes. Published by Elsevier Inc.
C1 [Serkin, Faye B.; Soderdahl, Douglas W.; Hernandez, Javier] Brooke Army Med Ctr, Dept Surg, Urol Serv, Ft Sam Houston, TX 78234 USA.
[Cullen, Jennifer; Chen, Yongmei] CPDR, Rockville, MD 20852 USA.
RP Hernandez, J (reprint author), Brooke Army Med Ctr, Dept Surg, Urol Serv, Ft Sam Houston, TX 78234 USA.
EM javier.hernandez@amedd.army.mil
NR 18
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U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1078-1439
EI 1873-2496
J9 UROL ONCOL-SEMIN ORI
JI Urol. Oncol.-Semin. Orig. Investig.
PD MAY-JUN
PY 2010
VL 28
IS 3
BP 302
EP 307
DI 10.1016/j.urolonc.2008.09.030
PG 6
WC Oncology; Urology & Nephrology
SC Oncology; Urology & Nephrology
GA 601ED
UT WOS:000278040100013
PM 19117774
ER
PT J
AU Anderson, BA
Maslia, ML
Caparoso, JL
Ausdemore, D
Aral, MM
AF Anderson, B. A.
Maslia, M. L.
Caparoso, J. L.
Ausdemore, D.
Aral, M. M.
TI Stochastic Analysis of Pesticide Transport in the Shallow Groundwater of
Oatland Island, Georgia, USA
SO WATER QUALITY EXPOSURE AND HEALTH
LA English
DT Article
DE Analytical solutions; Monte Carlo simulation; Pesticide transport;
Probabilistic analysis; Screening-level model; United States; Wetlands
AB Analytical models, when used in stochastic analysis mode, may provide an effective tool for making informed management decisions for simplified environmental systems. This approach was used to evaluate migration of an organochlorine pesticide plume in a shallow, unconfined aquifer underlying a barrier island in coastal Georgia, USA. The contaminant plume at the site consists of four isomers of benzene hexachloride (BHC), also known as hexachlorocyclohexane (HCH). The deterministic analysis conducted at the site, which used calibrated, single-value input parameters, indicates that the contaminant plume will not reach wetlands that are downgradient of the source. Given the uncertainties involved in the deterministic analysis, this outcome was not considered to be sufficient to make effective management decisions at the site. Subsequently, probabilistic analysis using a range of input parameter values was conducted to estimate the risk that the pesticide plume would reach the downgradient wetlands. The two-stage Monte Carlo analysis that was conducted indicates the probability that contaminant levels will exceed the detection limit of BHC (0.044 micrograms per liter) at the wetlands increases from 1 percent to a maximum of 13 percent during the period 2005-2065. This represents an 87% or greater confidence level that the pesticide plume will not reach the wetlands. This outcome was used to inform environmental management decisions at the site. The modeling analysis was conducted using the publicly available analytical contaminant transport analysis system (ACTS) software.
C1 [Anderson, B. A.; Maslia, M. L.] Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA.
[Caparoso, J. L.] US Army Ctr Hlth Promot & Prevent Med Europe, Landstuhl, Germany.
[Ausdemore, D.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Aral, M. M.] Georgia Inst Technol, Sch Civil & Environm Engn, Multimedia Environm Simulat Lab, Atlanta, GA 30332 USA.
RP Anderson, BA (reprint author), Agcy Tox Subst & Dis Registry, 4770 Buford Highway NE,Mail Stop F-59, Atlanta, GA 30341 USA.
EM baanderson@cdc.gov
FU Agency for Toxic Substances and Disease Registry; Centers for Disease
Control and Prevention
FX This project was funded by the Agency for Toxic Substances and Disease
Registry and the Centers for Disease Control and Prevention. The authors
acknowledge their colleagues at ATSDR, including Rene Suarez-Soto, John
Mann, and Susan Moore, for providing assistance and advice on this
project. Caryl Wipperfurth from the U.S. Geological Survey, Atlanta,
Georgia assisted with the preparation of illustrations.
NR 39
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U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1876-1658
EI 1876-1666
J9 WATER QUAL EXPOS HEA
JI Water Qual. Expos. Health
PD MAY
PY 2010
VL 2
IS 1
BP 47
EP 64
DI 10.1007/s12403-010-0023-6
PG 18
WC Water Resources
SC Water Resources
GA V35HF
UT WOS:000209140300003
ER
PT J
AU Link, A
Chen, MJ
Powers, SE
Grimberg, SJ
AF Link, Angela
Chen, Manjiang
Powers, Susan E.
Grimberg, Stefan J.
TI Effects of growth conditions and NAPL presence on transport of
Pseudomonas saccharophilia P15 through porous media
SO WATER RESEARCH
LA English
DT Article
DE Bacterial transport; Non-aqueous phase liquid; Growth state; Bacterial
adhesion; MATH assay
ID BACTERIAL TRANSPORT; MICROBIAL ADHESION; SOIL; DEPOSITION; PHENANTHRENE;
SURFACTANTS; HYDROCARBON; ADSORPTION; HEXADECANE; STRENGTH
AB Extensive research has been done to characterize transport of bacteria in porous media; however, little is understood on how the presence of non-aqueous phase liquids (NAPLs) coupled with the growth state and carbon source of bacteria affect bacterial transport. The objective of this research is to quantify the bacterial adhesion of Pseudomonas saccharophilia P15 (P15), which is known to biodegrade polycyclic aromatic hydrocarbons (PAH) and to interact with coal tars, within a NAPL-water-mineral system. Through a series of short-pulse column experiments, the transport and deposition of P15 in porous media (quartz sand) as a function of growth state and carbon sources (peptone and naphthalene), and in the presence and absence of residual NAPL (hexadecane), is measured and evaluated. Coating 20% of the quartz grain with hexadecane as a model NAPL increased the retention of P15 by as much as a factor of 26 as compared to the retention exhibited in quartz sand with no NAPL present. P15 grown on peptone and in the late exponential growth state exhibited a greater amount of deposition within the hexadecane column than when it was grown on naphthalene or was in early exponential growth phase. During early growth stage P15 grown on naphthalene adhered stronger to the porous media compared to when grown on peptone. Results were compared with results of MATH assays, where P15 partitioning to hexadecane was evaluated as a function of carbon source and growth state. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Link, Angela; Chen, Manjiang; Powers, Susan E.; Grimberg, Stefan J.] Clarkson Univ, Dept Civil & Environm Engn, Potsdam, NY 13699 USA.
[Link, Angela] US Army Corps Engineers, Kansas City, KS USA.
[Chen, Manjiang] GAI Consultants Inc, Orlando, FL USA.
RP Grimberg, SJ (reprint author), Clarkson Univ, Dept Civil & Environm Engn, Potsdam, NY 13699 USA.
EM grimberg@clarkson.edu
FU National Science Foundation [BES-9981494, BES 0217134, DGE-0234623]
FX The writers thank M. Borkovec from the University of Geneva,
Switzerland, for supplying the computer program used for calculating the
fit of the advection-dispersion-reactive equation to the experimental
data. This work was made possible by grants from the National Science
Foundation (BES-9981494, BES 0217134 and DGE-0234623). Any opinions,
findings, and conclusions or recommendations expressed in this material
are those of the authors and do not necessarily reflect the views of the
National Science Foundation.
NR 33
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U1 1
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD MAY
PY 2010
VL 44
IS 9
BP 2793
EP 2802
DI 10.1016/j.watres.2010.02.012
PG 10
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 599AK
UT WOS:000277882000011
PM 20219231
ER
PT J
AU Cho, JH
Chen, IR
AF Cho, Jin-Hee
Chen, Ing-Ray
TI Modeling and analysis of intrusion detection integrated with batch
rekeying for dynamic group communication systems in mobile ad hoc
networks
SO WIRELESS NETWORKS
LA English
DT Article
DE Group communication systems; Mobile ad hoc networks; Batch rekeying;
Intrusion detection; Stochastic Petri net; Group key management;
Security; Performance analysis
ID SECURE GROUP COMMUNICATIONS; WIRELESS NETWORKS; KEY MANAGEMENT; PEER
GROUPS; AGREEMENT
AB We investigate performance characteristics of secure group communication systems (GCSs) in mobile ad hoc networks that employ intrusion detection techniques for dealing with insider attacks tightly coupled with rekeying techniques for dealing with outsider attacks. The objective is to identify optimal settings including the best intrusion detection interval and the best batch rekey interval under which the system lifetime (mean time to security failure) is maximized while satisfying performance requirements. We develop a mathematical model based on stochastic Petri net to analyze tradeoffs between security and performance properties, when given a set of parameter values characterizing operational and environmental conditions of a GCS instrumented with intrusion detection tightly coupled with batch rekeying. We compare our design with a baseline system using intrusion detection integrated with individual rekeying to demonstrate the effectiveness.
C1 [Chen, Ing-Ray] Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA.
[Cho, Jin-Hee] USA, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD USA.
RP Chen, IR (reprint author), Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA.
EM jinhee.cho@us.army.mil; irchen@vt.edu
NR 36
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U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1022-0038
EI 1572-8196
J9 WIREL NETW
JI Wirel. Netw.
PD MAY
PY 2010
VL 16
IS 4
BP 1157
EP 1173
DI 10.1007/s11276-009-0194-x
PG 17
WC Computer Science, Information Systems; Engineering, Electrical &
Electronic; Telecommunications
SC Computer Science; Engineering; Telecommunications
GA 593KT
UT WOS:000277454200019
ER
PT J
AU Fritz, JM
Thackeray, A
Childs, JD
Brennan, GP
AF Fritz, Julie M.
Thackeray, Anne
Childs, John D.
Brennan, Gerard P.
TI A randomized clinical trial of the effectiveness of mechanical traction
for sub-groups of patients with low back pain: study methods and
rationale
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
ID LUMBAR DISC HERNIATION; OSWESTRY DISABILITY INDEX; PHYSICAL-THERAPISTS;
SUBGROUP ANALYSES; SAMPLE-SIZE; SCIATICA; MANAGEMENT; HEALTH; CARE;
QUESTIONNAIRE
AB Background: Patients with signs of nerve root irritation represent a sub-group of those with low back pain who are at increased risk of persistent symptoms and progression to costly and invasive management strategies including surgery. A period of non-surgical management is recommended for most patients, but there is little evidence to guide non-surgical decision-making. We conducted a preliminary study examining the effectiveness of a treatment protocol of mechanical traction with extension-oriented activities for patients with low back pain and signs of nerve root irritation. The results suggested this approach may be effective, particularly in a more specific sub-group of patients. The aim of this study will be to examine the effectiveness of treatment that includes traction for patients with low back pain and signs of nerve root irritation, and within the pre-defined sub-group.
Methods/Design: The study will recruit 120 patients with low back pain and signs of nerve root irritation. Patients will be randomized to receive an extension-oriented treatment approach, with or without the addition of mechanical traction. Randomization will be stratified based on the presence of the pre-defined sub-grouping criteria. All patients will receive 12 physical therapy treatment sessions over 6 weeks. Follow-up assessments will occur after 6 weeks, 6 months, and 1 year. The primary outcome will be disability measured with a modified Oswestry questionnaire. Secondary outcomes will include self-reports of low back and leg pain intensity, quality of life, global rating of improvement, additional healthcare utilization, and work absence. Statistical analysis will be based on intention to treat principles and will use linear mixed model analysis to compare treatment groups, and examine the interaction between treatment and sub-grouping status.
Discussion: This trial will provide a methodologically rigorous evaluation of the effectiveness of using traction for patients with low back pain and signs of nerve root irritation, and will examine the validity of a pre-defined sub-grouping hypothesis. The results will provide evidence to inform non-surgical decision-making for these patients.
C1 [Fritz, Julie M.; Thackeray, Anne; Brennan, Gerard P.] Rehabil Agcy, Intermt Healthcare, Salt Lake City, UT USA.
[Fritz, Julie M.; Thackeray, Anne] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA.
[Childs, John D.] Baylor Univ, USA, Ft Sam Houston, TX USA.
RP Fritz, JM (reprint author), Rehabil Agcy, Intermt Healthcare, Salt Lake City, UT USA.
EM julie.fritz@hsc.utah.edu
OI Thackeray, Anne/0000-0002-5496-7730
FU DJO incorporated, Vista, California, USA
FX We acknowledge a potential competing interest in the funding of this
study, which is provided by DJO incorporated, Vista, California, USA.
DJO is the parent company of Chattanooga, Inc., the manufacturer of the
3D ActiveTrac traction table used in this study.
NR 49
TC 9
Z9 10
U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD APR 30
PY 2010
VL 11
AR 81
DI 10.1186/1471-2474-11-81
PG 10
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA 603RF
UT WOS:000278225000002
PM 20433733
ER
PT J
AU Vo-Dinh, T
Dhawan, A
Norton, SJ
Khoury, CG
Wang, HN
Misra, V
Gerhold, MD
AF Vo-Dinh, Tuan
Dhawan, Anuj
Norton, Stephen J.
Khoury, Christopher G.
Wang, Hsin-Neng
Misra, Veena
Gerhold, Michael D.
TI Plasmonic Nanoparticles and Nanowires: Design, Fabrication and
Application in Sensing
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID ENHANCED-RAMAN-SCATTERING; SINGLE-MOLECULE; METALLIC NANOSTRUCTURES;
OPTICAL-PROPERTIES; SILVER ELECTRODE; LINEAR-CHAINS; HOT-SPOTS;
SPECTROSCOPY; SERS; DIMERS
AB This study involves two aspects of our investigations of plasmonics-active systems: (i) theoretical and simulation studies and (ii) experimental fabrication of plasmonics-active nanostructures. Two types of nanostructures are selected as the model systems for their unique plasmonics properties: (1) nanoparticles and (2) nanowires on substrate. Special focus is devoted to regions where the electromagnetic field is strongly concentrated by the metallic nanostructures or between nanostructures. The theoretical investigations deal with dimers of nanoparticles and nanoshells using a semianalytical method based on a multipole expansion (ME) and the finite-element method (FEM) in order to determine the electromagnetic enhancement, especially at the interface areas of two adjacent nanoparticles. The experimental study involves the design of plasmonics-active nanowire arrays on substrates that can provide efficient electromagnetic enhancement in regions around and between the nanostructures. Fabrication of these nanowire structures over large chip-scale areas (from a few millimeters to a few centimeters) as well as FDTD simulations to estimate the EM fields between the nanowires are described. The application of these nanowire chips using surface-enhanced Raman scattering for detection of chemicals and labeled DNA molecules is described to illustrate the potential of the plasmonics chips for sensing.
C1 [Vo-Dinh, Tuan; Dhawan, Anuj; Norton, Stephen J.; Khoury, Christopher G.; Wang, Hsin-Neng] Duke Univ, Fitzpatrick Inst Photon, Dept Biomed Engn, Durham, NC 27708 USA.
[Vo-Dinh, Tuan; Dhawan, Anuj; Norton, Stephen J.; Khoury, Christopher G.; Wang, Hsin-Neng] Duke Univ, Dept Chem, Durham, NC 27708 USA.
[Misra, Veena] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA.
[Gerhold, Michael D.] USA, Div Elect, Res Off, Durham, NC 27703 USA.
RP Vo-Dinh, T (reprint author), Duke Univ, Fitzpatrick Inst Photon, Dept Biomed Engn, Durham, NC 27708 USA.
EM tuan.vodinh@duke.edu
RI Wang, Hsin-Neng/D-9631-2013
FU National Institutes of Health [R01 EB006201, R01 ES014774-01A1]; Army
Research Office [W911NF-04-D-0001-0008]
FX This work was sponsored by the National Institutes of Health (Grants R01
EB006201 and R01 ES014774-01A1) and Army Research Office (Grant No.
W911NF-04-D-0001-0008).
NR 80
TC 50
Z9 50
U1 3
U2 47
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD APR 29
PY 2010
VL 114
IS 16
BP 7480
EP 7488
DI 10.1021/jp911355q
PG 9
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 586FP
UT WOS:000276889300039
PM 24839505
ER
PT J
AU Berg, MJ
Hill, SC
Videen, G
Gurton, KP
AF Berg, Matthew J.
Hill, Steven C.
Videen, Gorden
Gurton, Kristan P.
TI Spatial filtering technique to image and measure two-dimensional
near-forward scattering from single particles
SO OPTICS EXPRESS
LA English
DT Article
ID LIGHT-SCATTERING; SPHERES
AB This work describes the design and use of an optical apparatus to measure the far-field elastic light-scattering pattern for a single particle over two angular-dimensions. A spatial filter composed of a mirror with a small through-hole is used to enable collection of the pattern uncommonly close to the forward direction; to within tenths of a degree. Minor modifications of the design allow for the simultaneous measurement of a particle's image along with its two-dimensional scattering pattern. Example measurements are presented involving single micrometer-sized glass spherical particles confined in an electrodynamic trap and a dilute suspension of polystyrene latex particles in water. A small forward-angle technique, called Guinier analysis, is used to determine a particle-size estimate directly from the measured pattern without a priori knowledge of the particle refractive index. Comparison of these size estimates to those obtained by fitting the measurements to Mie theory reveals relative errors as low as 2%.
C1 [Berg, Matthew J.; Hill, Steven C.; Videen, Gorden; Gurton, Kristan P.] USA, Res Lab, RDRL CIE S, Adelphi, MD 20783 USA.
RP Berg, MJ (reprint author), USA, Res Lab, RDRL CIE S, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM mberg81@gmail.com
FU National Research Council; United States Defense Threat Reduction Agency
[DAAD17-03-0070]
FX This work was supported by a National Research Council Postdoctoral
Fellowship, funded by the United States Defense Threat Reduction Agency,
contract no. DAAD17-03-0070. The authors are thankful for assistance
provided by Melvin Felton, Chatt Williamson, and Drs. David Ligon,
Leonid Beresnev, Chris Sorensen, and comments provided by two anonymous
reviewers.
NR 15
TC 9
Z9 10
U1 3
U2 12
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD APR 26
PY 2010
VL 18
IS 9
BP 9486
EP 9495
DI 10.1364/OE.18.009486
PG 10
WC Optics
SC Optics
GA 588OR
UT WOS:000277082200078
PM 20588794
ER
PT J
AU Cole, B
Goldberg, L
King, V
Leach, J
AF Cole, Brian
Goldberg, Lew
King, Vernon
Leach, Jeff
TI Influence of UV illumination on the cold temperature operation of a
LiNbO3 Q-switched Nd:YAG laser
SO OPTICS EXPRESS
LA English
DT Article
ID LITHIUM-NIOBATE CRYSTAL; OPTICAL DAMAGE
AB UV illumination of a lithium niobate Q-switch was demonstrated as an effective means to eliminate a loss in hold-off and associated prelasing that occurs under cold temperature operation of Q-switched lasers. This degradation occurs due to the pyroelectric effect, where an accumulation of charge on crystal faces results in a reduction in the Q-switch hold-off and a spatially variable loss of the Q-switch in its high-transmission state, both resulting in lowering of the maximum Q-switched pulse energy. With UV illumination, the resulting creation of photo-generated carriers was shown to be effective in eliminating both of these effects. A Q-switched Nd:YAG laser utilizing UV-illuminated LiNbO3 was shown to operate under cold temperatures without prelasing or spatially variable loss. (C) 2010 Optical Society of America
C1 [Cole, Brian; Goldberg, Lew; King, Vernon; Leach, Jeff] USA, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Cole, B (reprint author), USA, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
EM info@nvl.army.mil
NR 14
TC 4
Z9 4
U1 0
U2 2
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD APR 26
PY 2010
VL 18
IS 9
BP 9622
EP 9627
DI 10.1364/OE.18.009622
PG 6
WC Optics
SC Optics
GA 588OR
UT WOS:000277082200093
PM 20588809
ER
PT J
AU Crum-Cianflone, NF
Roediger, M
Eberly, LE
Vyas, K
Landrum, ML
Ganesan, A
Weintrob, AC
Barthel, RV
Agan, BK
AF Crum-Cianflone, Nancy F.
Roediger, Mollie
Eberly, Lynn E.
Vyas, Kurt
Landrum, Mike L.
Ganesan, Anuradha
Weintrob, Amy C.
Barthel, Robert Vincent
Agan, Brian K.
CA Infect Dis Clinical Res Program HI
TI Obesity among HIV-infected persons: impact of weight on CD4 cell count
SO AIDS
LA English
DT Article
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; DISEASE PROGRESSION; SURVIVAL;
OVERWEIGHT; ADULTS; AIDS; PREDICTOR; COHORT; ALPHA
AB To assess the effect of obesity on CD4 cell counts, we estimated the association of time-updated BMI categories with CD4 changes among 1001 documented HIV seroconverters. During the pre-highly active antiretroviral therapy (HAART) era, a higher BMI was associated with less reduction in CD4 cell counts over time. However during the HAART era, obese versus normal weight patients had smaller increases in CD4 cell counts (+69 versus +116 cells, P=0.01). Lower CD4 cell counts may now be another adverse consequence of obesity.
C1 [Crum-Cianflone, Nancy F.; Roediger, Mollie; Eberly, Lynn E.; Vyas, Kurt; Landrum, Mike L.; Ganesan, Anuradha; Weintrob, Amy C.; Barthel, Robert Vincent; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Crum-Cianflone, Nancy F.; Vyas, Kurt] Naval Med Ctr San Diego, Infect Dis Clin, San Diego, CA USA.
[Roediger, Mollie; Eberly, Lynn E.] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
[Landrum, Mike L.] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA.
[Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA.
[Weintrob, Amy C.] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA.
[Barthel, Robert Vincent] Naval Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA.
RP Crum-Cianflone, NF (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
OI Agan, Brian/0000-0002-5114-1669; Eberly, Lynn/0000-0003-4763-330X
FU Infectious Disease Clinical Research Program (IDCRP) [IDCRP-RV168F];
Department of Defense (DoD); National Institute of Allergy and
Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072];
N.F.C.C.; B.K.A
FX The present study (IDCRP-RV168F) was supported by the Infectious Disease
Clinical Research Program (IDCRP), a Department of Defense (DoD) program
executed through the Uniformed Services University of the Health
Sciences. This project has been funded in whole, or in part, with
federal funds from the National Institute of Allergy and Infectious
Diseases, National Institutes of Health (NIH), under Inter-Agency
Agreement Y1-AI-5072.; Obtaining funding from N.F.C.C. and B.K.A.
NR 20
TC 25
Z9 25
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
J9 AIDS
JI Aids
PD APR 24
PY 2010
VL 24
IS 7
BP 1069
EP 1072
DI 10.1097/QAD.0b013e328337fe01
PG 4
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 582AN
UT WOS:000276567500021
PM 20216300
ER
PT J
AU Mukhopadhyay, S
Gowtham, S
Scheicher, RH
Pandey, R
Karna, SP
AF Mukhopadhyay, Saikat
Gowtham, S.
Scheicher, Ralph H.
Pandey, Ravindra
Karna, Shashi P.
TI Theoretical study of physisorption of nucleobases on boron nitride
nanotubes: a new class of hybrid nano-biomaterials
SO NANOTECHNOLOGY
LA English
DT Article
ID SINGLE-WALLED CARBON; MOLECULAR-DYNAMICS; DNA; FUNCTIONALIZATION;
EXCHANGE; COVALENT; BINDING; COMPLEX
AB We investigate the adsorption of the nucleic acid bases-adenine (A), guanine (G), cytosine (C), thymine (T) and uracil (U)-on the outer wall of a high curvature semiconducting single-walled boron nitride nanotube (BNNT) by first-principles density functional theory calculations. The calculated binding energy shows the order: G > A approximate to C approximate to T approximate to U, implying that the interaction strength of the high curvature BNNT with the nucleobases, G being an exception, is nearly the same. A higher binding energy for the G-BNNT conjugate appears to result from hybridization of the molecular orbitals of G and the BNNT. A smaller energy gap predicted for the G-BNNT conjugate relative to that of the pristine BNNT may be useful in the application of this class of biofunctional materials to the design of next-generation sensing devices.
C1 [Mukhopadhyay, Saikat; Gowtham, S.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[Scheicher, Ralph H.] Uppsala Univ, Dept Phys & Mat Sci, SE-75121 Uppsala, Sweden.
[Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
EM pandey@mtu.edu
RI Scheicher, Ralph/G-1740-2012; Mukhopadhyay, Saikat/B-4402-2011
FU Army Research Office [W911NF-09-1-0221]; Wenner-Gren Foundations in
Stockholm
FX Helpful discussions with Haiying He are gratefully acknowledged. The
work at Michigan Technological University was performed under support by
the Army Research Office through contract number W911NF-09-1-0221. RHS
acknowledges financial support from Wenner-Gren Foundations in
Stockholm.
NR 37
TC 44
Z9 44
U1 1
U2 27
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0957-4484
EI 1361-6528
J9 NANOTECHNOLOGY
JI Nanotechnology
PD APR 23
PY 2010
VL 21
IS 16
AR 165703
DI 10.1088/0957-4484/21/16/165703
PG 6
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA 575YY
UT WOS:000276111200022
PM 20351402
ER
PT J
AU Jindal, RM
Ricordi, C
Shriver, CD
AF Jindal, Rahul M.
Ricordi, Camillo
Shriver, Craig D.
TI Autologous Pancreatic Islet Transplantation for Severe Trauma
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 [Jindal, Rahul M.; Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Ricordi, Camillo] Univ Miami, Diabet Res Inst, Miami, FL USA.
RP Jindal, RM (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA.
EM jindalr@msn.com
NR 3
TC 19
Z9 19
U1 1
U2 2
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD APR 22
PY 2010
VL 362
IS 16
BP 1550
EP 1550
DI 10.1056/NEJMc0912392
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 586GP
UT WOS:000276894700033
PM 20410526
ER
PT J
AU DeVine, J
Chutkan, N
Norvell, DC
Dettori, JR
AF DeVine, John
Chutkan, Norman
Norvell, Daniel C.
Dettori, Joseph R.
TI Avoiding Wrong Site Surgery A Systematic Review
SO SPINE
LA English
DT Review
DE wrong site; wrong level; wrong patient; wrong side
ID LEVEL SURGERY; DISKECTOMY
AB Study Design. Systematic review.
Objective. To report the incidence and causes of wrong site surgery and determine what preoperative measures are effective in preventing wrong site surgery.
Summary of Background Data. From 1995 to 2005, the Joint Commission (JC) sentinel event statistics database ranked wrong site surgery as the second most frequently reported event with 455 of 3548 sentinel events (12.8%). Although the event seems to be rare, the incidence of these complications has been difficult to measure and quantify. The implications for wrong site surgery go beyond the effects to the patient. Such an event has profound medical, legal, social, and emotional implications.
Methods. A systematic review of the English language literature was undertaken for articles published between 1990 and December 2008. Electronic databases and reference lists of key articles were searched to identify the articles defining wrong site surgery and reporting wrong site events. Two independent reviewers assessed the level of evidence quality using the Grading of Recommendations Assessment, Development, and Evaluation criteria and disagreements were resolved by consensus.
Results. The estimated rate of wrong site surgery varies widely ranging from 0.09 to 4.5 per 10,000 surgeries performed. There is no literature to substantiate the effectiveness of the current JC Universal Protocol in decreasing the rate of wrong site, wrong level surgery.
Conclusion. Wrong site surgery may be preventable. We suggest that the North American Spine Society and JC checklists are insufficient on their own to minimize this complication. Therefore, in addition to these protocols, we recommend intraoperative imaging after exposure- and marking of a fixed anatomic structure. This imaging should be compared with routine preoperative studies to determine the correct site for spine surgery.
C1 [DeVine, John] Eisenhower Army Med Ctr, Orthoped Serv, Dept Surg, Ft Gordon, GA 30809 USA.
[Chutkan, Norman] Med Coll Georgia, Dept Orthopaed Surg, Augusta, GA 30912 USA.
[Norvell, Daniel C.; Dettori, Joseph R.] Spectrum Res Inc, Tacoma, WA USA.
RP DeVine, J (reprint author), Eisenhower Army Med Ctr, Orthoped Serv, Dept Surg, 300 E Hosp Rd, Ft Gordon, GA 30809 USA.
EM john-devine@comcast.net
FU AOSpine North America
FX Supported by AOSpine North America. Analytic support for this work was
provided by Spectrum Research, Inc. with funding from AOSpine North
America. No benefits in any form have been or will be received from a
commercial party related directly or indirectly to the subject of this
manuscript.
NR 26
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U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-2436
J9 SPINE
JI SPINE
PD APR 20
PY 2010
VL 35
IS 9
SU S
BP S28
EP S36
DI 10.1097/BRS.0b013e3181d833ac
PG 9
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 590KI
UT WOS:000277224100004
PM 20407349
ER
PT J
AU Martin, SS
Bakken, RR
Lind, CM
Garcia, P
Jenkins, E
Glass, PJ
Parker, MD
Hart, MK
Fine, DL
AF Martin, Shannon S.
Bakken, Russell R.
Lind, Cathleen M.
Garcia, Patricia
Jenkins, Erin
Glass, Pamela J.
Parker, Michael D.
Hart, Mary Kate
Fine, Donald L.
TI Evaluation of formalin inactivated V3526 virus with adjuvant as a next
generation vaccine candidate for Venezuelan equine encephalitis virus
SO VACCINE
LA English
DT Article
DE Venezuelan equine encephalitis virus (VEEV); Formalin-inactivated
vaccine; Intramuscular vaccination
ID ENCEPHALOMYELITIS VIRUS; AEROSOL CHALLENGE; NEUTRALIZING ANTIBODIES;
ATTENUATED TC-83; VEE VIRUS; IN-VITRO; C-CLASS; PROTECTION; INFECTION;
MICE
AB V3526, a genetically modified strain of Venezuelan equine encephalitis virus (VEEV), was formalin inactivated for evaluation as a next generation vaccine candidate for VEEV. In this study, we tested formalin-inactivated V3526 (fV3526) with and without adjuvant for immunogenicity and efficacy in BALB/c mice and results were compared to the existing inactivated VEEV vaccine, C84. Mice were vaccinated intramuscularly (IM) or subcutaneously (SC) with fV3526 formulations and challenged with VEEV IAB Trinidad donkey (VEEV TrD) strain by SC or aerosol exposure. Efficacy following SC or aerosol challenge was not significantly different between the fV3526 formulations or compared to C84 despite C84 being administered in more doses and higher concentration of viral protein per dose. These data support further evaluation of fV3526 formulations as a next generation VEEV vaccine. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Martin, Shannon S.; Jenkins, Erin; Hart, Mary Kate; Fine, Donald L.] DynPort Vaccine Co LLC DVC, Frederick, MD 21702 USA.
[Bakken, Russell R.; Lind, Cathleen M.; Garcia, Patricia; Glass, Pamela J.; Parker, Michael D.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
RP Martin, SS (reprint author), DynPort Vaccine Co LLC DVC, 64 Thomas Johnson Dr, Frederick, MD 21702 USA.
EM smartin40@csc.com
RI Glass, Pamela/G-1170-2011
FU National Institute of Allergy and Infectious Diseases [1UC1AI062538-01];
Joint Science and Technology Office-Chemical, Biological Defense
[Plan1.1C0041_09_RD_B]
FX This study was funded by the National Institute of Allergy and
Infectious Diseases (1UC1AI062538-01) and Joint Science and Technology
Office-Chemical, Biological Defense ((Plan1.1C0041_09_RD_B). We thank
the aerobiology staff at USAM-RIID for their contributions to the
aerosol challenge components of this study.
NR 52
TC 10
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U1 2
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD APR 19
PY 2010
VL 28
IS 18
BP 3143
EP 3151
DI 10.1016/j.vaccine.2010.02.056
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 588JA
UT WOS:000277064500011
PM 20193792
ER
PT J
AU Banks, HD
AF Banks, Harold D.
TI Torquoselectivity Studies in the Generation of Azomethine Ylides from
Substituted Aziridines
SO JOURNAL OF ORGANIC CHEMISTRY
LA English
DT Article
ID RING-OPENING REACTIONS; CONROTATORY ELECTROCYCLIC REACTIONS; GEMINAL
BOND PARTICIPATION; CLICK CHEMISTRY; NAZAROV REACTION;
ASYMMETRIC-SYNTHESIS; 3+2 CYCLOADDITION; SOLVATION MODELS; SILYL GROUPS;
CYCLOBUTENES
AB Aziridines are useful precursors to the azomethine ylide family of 1,3-dipoles whose cycloaddition chemistry has been extensively exploited in the synthesis of heterocyclic targets. The torquoselectivity of aziridines that lack a plane of symmetry was investigated as an essential component of the calculation of the overall relative reaction rates and in prediction of the stereochemistry of the 2,3-trans compounds in 1,3-dipolar cycloaddition chemistry. It has been found at the MP2(Full)/6-311++G(d,p)//MP2(Full)/6-31+G(d) level that outward rotation is preferred for electronegative or anionic substituents while electropositive and cationic substituents favor inward rotation. After consideration of frontier molecular orbital theory, inductive, resonance, and electrostatic effects, an explanation of the preferred direction of rotation during ring cleavage that is based on substituent electron-withdrawing ability by means of a polar effect is presented.
C1 USA, Edgewood Chem Biol Ctr APG, Aberdeen Proving Ground, MD 21010 USA.
RP Banks, HD (reprint author), USA, Edgewood Chem Biol Ctr APG, Aberdeen Proving Ground, MD 21010 USA.
EM harold.banks@us.army.mil
NR 135
TC 13
Z9 13
U1 2
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-3263
J9 J ORG CHEM
JI J. Org. Chem.
PD APR 16
PY 2010
VL 75
IS 8
BP 2510
EP 2517
DI 10.1021/jo902600y
PG 8
WC Chemistry, Organic
SC Chemistry
GA 581WQ
UT WOS:000276556600010
PM 20329779
ER
PT J
AU Ghosh, S
Ingerman, LA
Frye, AG
Lee, SJ
Gagne, MR
Waters, ML
AF Ghosh, Soumyadip
Ingerman, Lindsey A.
Frye, Aaron G.
Lee, Stephen J.
Gagne, Michel R.
Waters, Marcey L.
TI Dynamic Cyclic Thiodepsipeptide Libraries From Thiol-Thioester Exchange
SO ORGANIC LETTERS
LA English
DT Article
ID HISTONE DEACETYLASE INHIBITORS; COMBINATORIAL LIBRARIES; PEPTIDES;
CHEMISTRY; LIGATION
AB Thiol thioester exchange was found to readily generate libraries of cyclic thiodepsipeptides under thermodynamic control, which will enable their use in a variety of dynamic combinatorial chemistry assays. The kinetic determinants of macrocycle formation and the role of amino acid structure on the reaction dynamics are discussed.
C1 [Ghosh, Soumyadip; Ingerman, Lindsey A.; Frye, Aaron G.; Gagne, Michel R.; Waters, Marcey L.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.
[Lee, Stephen J.] USA, Res Off, Res Triangle Pk, NC 27709 USA.
RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA.
EM mgagne@unc.edu; mlwaters@unc.edu
FU Defense Threat Reduction Agency [DTRA, W911NF-06-1-0169]
FX We thank the Defense Threat Reduction Agency (DTRA, W911NF-06-1-0169)
for support.
NR 21
TC 15
Z9 15
U1 0
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1523-7060
J9 ORG LETT
JI Org. Lett.
PD APR 16
PY 2010
VL 12
IS 8
BP 1860
EP 1863
DI 10.1021/ol1004752
PG 4
WC Chemistry, Organic
SC Chemistry
GA 581YT
UT WOS:000276562600054
PM 20329734
ER
PT J
AU Srikiatkhachorn, A
Gibbons, RV
Green, S
Libraty, DH
Thomas, SJ
Endy, TP
Vaughn, DW
Nisalak, A
Ennis, FA
Rothman, AL
Nimmannitaya, S
Kalayanarooj, S
AF Srikiatkhachorn, Anon
Gibbons, Robert V.
Green, Sharone
Libraty, Daniel H.
Thomas, Stephen J.
Endy, Timothy P.
Vaughn, David W.
Nisalak, Ananda
Ennis, Francis A.
Rothman, Alan L.
Nimmannitaya, Suchitra
Kalayanarooj, Siripen
TI Dengue Hemorrhagic Fever: The Sensitivity and Specificity of the World
Health Organization Definition for Identification of Severe Cases of
Dengue in Thailand, 1994-2005
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID DISEASE SEVERITY; CLASSIFICATION-SYSTEM; INFECTION; CHILDREN; DIAGNOSIS;
NICARAGUA; THERAPY; VIRUSES; ILLNESS
AB Background. Dengue virus infection causes a spectrum of clinical manifestations, usually classified according to the World Health Organization (WHO) guidelines into dengue fever (DF) and dengue hemorrhagic fever (DHF). The ability of these guidelines to categorize severe dengue illness has recently been questioned.
Methods. We evaluated dengue case definitions in a prospective study at a pediatric hospital in Bangkok, Thailand, during 1994-2005. One thousand thirteen children were enrolled within the first 3 days after onset of fever and observed with standardized data collection. Cases were classified on the basis of application of the strict WHO criteria. All dengue virus infections were laboratory confirmed. We retrospectively grouped patients on the basis of whether they received significant intervention based on fluid replacement and/or requirements for blood transfusion.
Results. Eighty-five (58%) of 150 persons with DHF, 40 (15%) of 264 with DF, and 73 (12%) of 599 with other febrile illnesses (OFIs) received significant intervention. Sixty-eight percent of dengue cases requiring intervention met strict WHO criteria for DHF. In contrast, only 1% of OFI cases met WHO criteria for DHF. Plasma leakage and thrombocytopenia were the 2 components contributing to the specificity of the WHO case definition and identified dengue cases that required intervention. Hemorrhagic tendency did not reliably differentiate DF and DHF. In DF cases, thrombocytopenia and bleeding were associated with severity.
Conclusions. Dengue illness is heterogeneous in severity, and severe clinical features occurred in patients whose cases were not characterized as DHF. The WHO case definition of DHF demonstrated sensitivity of 62% and specificity of 92% for identification of dengue illness requiring intervention, without the need for laboratory confirmation of dengue virus infection, in an area of endemicity.
C1 [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01655 USA.
[Endy, Timothy P.] SUNY Upstate Med Univ, Syracuse, NY USA.
[Vaughn, David W.] USA, Mil Infect Dis Res Program, Med Res & Mat Command, Ft Detrick, MD USA.
[Gibbons, Robert V.; Thomas, Stephen J.; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Nimmannitaya, Suchitra; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
RP Srikiatkhachorn, A (reprint author), Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, 55 Lake Ave N,Rm S6-862, Worcester, MA 01655 USA.
EM anon.srikiatkhachorn@umassmed.edu
FU National Institutes of Health [NIH-P01AI34533]; Military Infectious
Disease Research Program
FX The National Institutes of Health (NIH-P01AI34533) and the Military
Infectious Disease Research Program. The opinions or assertions
contained herein are the private ones of the authors and are not to be
construed as official or reflecting the view of the US Government.
NR 30
TC 50
Z9 50
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD APR 15
PY 2010
VL 50
IS 8
BP 1135
EP 1143
DI 10.1086/651268
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 570BF
UT WOS:000275645900008
PM 20205587
ER
PT J
AU Van Horn, GT
Goodrich, A
Winslow, DL
AF Van Horn, Gerald T.
Goodrich, Aryn
Winslow, Dean L.
TI Gross Hematuria in a Young Iraqi Man - Diagnosis: infection due to
Schistosoma haematobium
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Editorial Material
ID GRANULOMA
C1 [Winslow, Dean L.] Stanford Univ, Sch Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA.
[Van Horn, Gerald T.] Walter Reed Army Med Ctr, Dept Pathol & Area Lab Serv, Washington, DC 20307 USA.
[Goodrich, Aryn] 115th Combat Support Hosp, Ft Polk, LA USA.
[Winslow, Dean L.] Santa Clara Valley Med Ctr, San Jose, CA 95128 USA.
RP Winslow, DL (reprint author), Stanford Univ, Sch Med, Div Infect Dis & Geog Med, 300 Pasteur Dr,Rm S101D, Stanford, CA 94305 USA.
EM dwinslow@stanford.edu
NR 4
TC 0
Z9 0
U1 1
U2 1
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD APR 15
PY 2010
VL 50
IS 8
BP 1144
EP +
DI 10.1086/651270
PG 3
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 570BF
UT WOS:000275645900017
PM 20233043
ER
PT J
AU Halstead, SB
Thomas, SJ
AF Halstead, Scott B.
Thomas, Stephen J.
TI Japanese Encephalitis: New Options for Active Immunization
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID SA 14-14-2 VACCINE; NEUTRALIZING ANTIBODY-RESPONSE;
NILE-VIRUS-INFECTIONS; VERO CELLS; ATTENUATED VACCINE; CONTROLLED
PHASE-3; ENVELOPE GENES; PYRETHROID INSECTICIDE; FLAVIVIRUS INFECTIONS;
SA-14-14-2 VACCINE
AB Japanese encephalitis (JE) is a mosquito-borne flavivirus infection responsible for significant morbidity and mortality across Asia. Indigenous populations and those who undertake short-and long-term travel to endemic regions are at risk of infection and development of neuroinvasive disease. Effective mouse brain-derived vaccines have been available in select countries, including the United States, for decades. Limited access in Asia and safety concerns with regard to mouse brain products prompted the Chinese to develop a live, attenuated virus vaccine (SA14-14-2; Chengdu Institute of Biological Products), which has proven to be safe and efficacious following administration of >300 million doses. Recently, the portfolio of JE vaccines increased again with licensure in the United States, Europe, and Australia of a purified, inactivated virus JE vaccine (IC51; Intercell AG) and filing for licensure in Thailand and Australia of a Yellow fever-JE chimeric vaccine (ChimeriVax-JE; Sanofi Pasteur). JE is a vaccine-preventable disease with numerous options now available for active immunization. Aggressive and responsible vaccination programs should greatly diminish the burden of disease.
C1 [Halstead, Scott B.] Pediat Dengue Vaccine Initiat, Res Program, Rockville, MD 20852 USA.
[Thomas, Stephen J.] US Army Med Component Armed Forces Res Inst Med S, Dept Virol, Bangkok, Thailand.
RP Halstead, SB (reprint author), Pediat Dengue Vaccine Initiat, Res Program, 5824 Edson Lane, Rockville, MD 20852 USA.
EM halsteads@erols.com
NR 84
TC 47
Z9 54
U1 0
U2 4
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD APR 15
PY 2010
VL 50
IS 8
BP 1155
EP 1164
DI 10.1086/651271
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 570BF
UT WOS:000275645900011
PM 20218889
ER
PT J
AU Okulicz, JF
Grandits, GA
Weintrob, AC
Landrum, ML
Ganesan, A
Crum-Cianflone, NF
Agan, BK
Marconi, VC
AF Okulicz, Jason F.
Grandits, Greg A.
Weintrob, Amy C.
Landrum, Michael L.
Ganesan, Anuradha
Crum-Cianflone, Nancy F.
Agan, Brian K.
Marconi, Vincent C.
TI CD4 T Cell Count Reconstitution in HIV Controllers after Highly Active
Antiretroviral Therapy
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; LOW-LEVEL VIREMIA; RNA LEVELS;
INDIVIDUALS; INFECTION; RESPONSES; ABSENCE
AB Sixty-two human immunodeficiency virus (HIV) controllers (6 elite and 56 viremic controllers) in the US Military Department of Defense HIV Natural History Study cohort initiated highly active antiretroviral therapy (HAART) and achieved statistically significant mean CD4 cell count increases, although the gains were lower than those in treated noncontrollers. HIV controllers experienced CD4 cell count reconstitution with HAART regardless of pretherapy viral load, including patients with undetectable viral loads at HAART initiation.
C1 [Okulicz, Jason F.; Grandits, Greg A.; Weintrob, Amy C.; Landrum, Michael L.; Ganesan, Anuradha; Crum-Cianflone, Nancy F.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Ganesan, Anuradha] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA.
[Okulicz, Jason F.; Landrum, Michael L.] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA.
[Grandits, Greg A.] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
[Weintrob, Amy C.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA.
[Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, Infect Dis Clin, San Diego, CA USA.
[Marconi, Vincent C.] Emory Univ, Sch Med, Atlanta, GA USA.
RP Okulicz, JF (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM Jason.okulicz@amedd.army.mil
RI Marconi, Vincent/N-3210-2014;
OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669
FU Uniformed Services University of the Health Sciences [IDCRP-000-05];
National Institute of Allergy and Infectious Diseases, National
Institutes of Health [Y1-AI-5072]
FX Support for this work (IDCRP-000-05) was provided by the Infectious
Disease Clinical Research Program, a Department of Defense program
executed through the Uniformed Services University of the Health
Sciences. This project has been funded in whole or in part with federal
funds from the National Institute of Allergy and Infectious Diseases,
National Institutes of Health, under interagency agreement Y1-AI-5072.
NR 13
TC 19
Z9 19
U1 0
U2 0
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD APR 15
PY 2010
VL 50
IS 8
BP 1187
EP 1191
DI 10.1086/651421
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 570BF
UT WOS:000275645900015
PM 20218878
ER
PT J
AU Little, JW
Olver, KA
AF Little, J. W.
Olver, K. A.
TI Stark shifts in mid-infrared type II quantum well transitions
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID OPTIC EFFECT DEVICE; INFRARED PHOTODIODES; MU-M; DETECTORS; SWITCH
AB We have studied electric field induced (Stark) shifts in mid-infrared (IR) transitions that occur in type II AlSb/InAs/GaSb quantum wells. Because of the spatial separation of the electron and hole wave functions in the type II system, the potential drop between the layers dominates the shift in the real-space-indirect transition energies when an external electric field is applied. This can result in either a redshift or a blueshift, depending on the ordering of the quantum well layers within the intrinsic region of a p-i-n diode. The case in which a reverse bias on the diode yields a blueshift in the transition energy is of particular interest for IR electro-optic device applications. The modulator section of an integrated source/waveguide modulator would strongly absorb at zero bias and could be biased into transparency, and bistable optical switches could be made more efficient than with redshifting devices. We have used low temperature current-voltage, capacitance-voltage, and photocurrent measurements to characterize a type II quantum well structure that exhibits a blueshift in the lowest energy transitions that is roughly linear with applied bias and is comparable to the potential drop across the structure. (C) 2010 American Institute of Physics. [doi:10.1063/1.3383040]
C1 [Little, J. W.; Olver, K. A.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Little, JW (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM jlittle@arl.army.mil
NR 16
TC 2
Z9 2
U1 0
U2 4
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD APR 15
PY 2010
VL 107
IS 8
AR 083108
DI 10.1063/1.3383040
PG 4
WC Physics, Applied
SC Physics
GA 591LX
UT WOS:000277303200009
ER
PT J
AU Cheezum, MK
Lettieri, CJ
AF Cheezum, Michael K.
Lettieri, Christopher J.
TI Obstructive Sleep Apnea Presenting as Pseudopheochromocytoma
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Article
DE Obstructive sleep apnea; pheochromocytoma; pseudopheochromocytoma;
endocrinopathy
ID POSITIVE AIRWAY PRESSURE; HYPERTENSION
AB A 39-year-old man with a history of poorly controlled hypertension presented with a 2-year history of fatigue, daytime somnolence, and intermittent episodes of diaphoresis and palpitations. Episodes were self-limiting, lasting approximately 5-10 minutes and occurred several times per month, most notably at night Laboratory evaluation was significant for elevated 24-h urinary catecholamine levels, suggestive of pheochromocytoma However, thorough imaging failed to identify a catecholamine-secreting tumor Subsequent polysomnography revealed severe obstructive sleep apnea, with an apnea-hypopnea index of 112 events/h. After one month of continuous positive airway pressure therapy, the patient experienced resolution of his presenting symptoms, improved blood pressure control and normalization of his urinary catecholamine levels. This case highlights sleep disordered breathing as a potentially reversible cause of pseudopheochromocytoma
C1 [Cheezum, Michael K.; Lettieri, Christopher J.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA.
[Lettieri, Christopher J.] Walter Reed Army Med Ctr, Dept Pulm Crit Care & Sleep Med, Washington, DC 20307 USA.
RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA.
NR 6
TC 3
Z9 6
U1 0
U2 1
PU AMER ACAD SLEEP MEDICINE
PI WESTCHESTER
PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA
SN 1550-9389
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PD APR 15
PY 2010
VL 6
IS 2
BP 190
EP 191
PG 2
WC Clinical Neurology
SC Neurosciences & Neurology
GA 584XV
UT WOS:000276788500014
PM 20411698
ER
PT J
AU Carter, KA
Lettieri, CJ
Pena, JM
AF Carter, Kevin A.
Lettieri, Christopher J.
Pena, Jennifer M.
TI An Unusual Cause of Insomnia Following IED-Induced Traumatic Brain
Injury
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Editorial Material
C1 [Pena, Jennifer M.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA.
[Lettieri, Christopher J.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
NR 5
TC 3
Z9 3
U1 0
U2 0
PU AMER ACAD SLEEP MEDICINE
PI WESTCHESTER
PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA
SN 1550-9389
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PD APR 15
PY 2010
VL 6
IS 2
BP 205
EP 206
PG 2
WC Clinical Neurology
SC Neurosciences & Neurology
GA 584XV
UT WOS:000276788500017
PM 20411701
ER
PT J
AU Pelak, K
Goldstein, DB
Walley, NM
Fellay, J
Ge, D
Shianna, KV
Gumbs, C
Gao, X
Maia, JM
Cronin, KD
Hussain, SK
Carrington, M
Michael, NL
Weintrob, AC
AF Pelak, Kimberly
Goldstein, David B.
Walley, Nicole M.
Fellay, Jacques
Ge, Dongliang
Shianna, Kevin V.
Gumbs, Curtis
Gao, Xiaojiang
Maia, Jessica M.
Cronin, Kenneth D.
Hussain, Shehnaz K.
Carrington, Mary
Michael, Nelson L.
Weintrob, Amy C.
CA Natl Inst Allergy Infect Dis
TI Host Determinants of HIV-1 Control in African Americans
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; WHOLE-GENOME ASSOCIATION; LINKAGE
DISEQUILIBRIUM; VIRAL LOAD; HLA; SUSCEPTIBILITY; INFECTION; GENETICS;
MODELS; SET
AB We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.
C1 [Pelak, Kimberly; Goldstein, David B.; Walley, Nicole M.; Fellay, Jacques; Ge, Dongliang; Shianna, Kevin V.; Gumbs, Curtis; Maia, Jessica M.; Cronin, Kenneth D.] Duke Univ, Sch Med, Ctr Human Genome Variat, Durham, NC USA.
[Gao, Xiaojiang; Carrington, Mary] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick, Frederick, MD 21701 USA.
[Michael, Nelson L.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA.
[Weintrob, Amy C.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Hussain, Shehnaz K.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA.
RP Weintrob, AC (reprint author), Walter Reed Army Med Ctr, Bldg 2,Ward 63,Room 6312, Washington, DC 20307 USA.
EM amy.weintrob@us.army.mil
RI Fellay, Jacques/A-6681-2009; Marconi, Vincent/N-3210-2014
OI Fellay, Jacques/0000-0002-8240-939X; Marconi,
Vincent/0000-0001-8409-4689
FU National Institute of Allergy and Infectious Diseases [NIAID], National
Institutes of Health [NIH] [Y1-AI5072, 5 T32 GM007754-29, AI067854];
National Cancer Institute (NCI), NIH [HHSN261200800001E]; National
Heart, Lung, and Blood Institute [UO1-AI-35042, 5-M01-RR-00052,
UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613,
UO1-AI-35041]
FX Financial support: Infectious Disease Clinical Research Program
(Department of Defense program executed through the Uniformed Services
University of the Health Sciences and funded by the National Institute
of Allergy and Infectious Diseases [NIAID], National Institutes of
Health [NIH], under interagency agreement Y1-AI5072); NIH (genetics
training grant 5 T32 GM007754-29 to K. P.); NIAID Center for HIV/AIDS
Vaccine Immunology (grant AI067854); National Cancer Institute (NCI),
NIH (contract HHSN261200800001E); Center for Cancer Research, NCI, NIH.
The Multicenter AIDS Cohort Study is funded by NIAID with supplemental
funding from NCI and the National Heart, Lung, and Blood Institute
(grants UO1-AI-35042, 5-M01-RR-00052 [GCRC], UO1-AI-35043, UO1-AI-37984,
UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, and UO1-AI-35041).
NR 19
TC 85
Z9 87
U1 0
U2 7
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD APR 15
PY 2010
VL 201
IS 8
BP 1141
EP 1149
DI 10.1086/651382
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 568AJ
UT WOS:000275493400006
PM 20205591
ER
PT J
AU Sorescu, DC
Rice, BM
AF Sorescu, Dan C.
Rice, Betsy M.
TI Theoretical Predictions of Energetic Molecular Crystals at Ambient and
Hydrostatic Compression Conditions Using Dispersion Corrections to
Conventional Density Functionals (DFT-D)
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID SMALL ORGANIC-MOLECULES; PENTAERYTHRITOL TETRANITRATE PETN; DER-WAALS
CORRECTION; AB-INITIO; SOLID NITROMETHANE; BLIND TEST;
1,3,5,7-TETRANITRO-1,3,5,7-TETRAAZACYCLOOCTANE HMX; DYNAMICS
SIMULATIONS; NEUTRON-DIFFRACTION; GAMMA-RDX
AB Theoretical predictions of the crystallographic properties of a series of 10 energetic molecular crystals have been done using a semiempirical correction to account for the van der Waals interactions in conventional density functional theory (termed DFT-D) as implemented in a pseudopotential plane-wave code This series contains compounds representative for energetic materials applications, that is, hexahydro-1,3,5-trinitro-1,3,5-s triazine (alpha- and gamma-RDX phases), 1,3,5.7-tetramtro-1,3,5,7-tetraaza-cyclooctane (beta-, alpha-, and delta-HMX phases), 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (CL20) (epsilon-, beta-, and gamma-HNIW phases), nitromethane (NM), trans-1,2,-dinitrocyclopropane, 1,2,3,5,7-pentanitrocubane (PNC), pentaerythruol tetramtrate (PETN), 2,4,6-trinitro-1,3,5-benzenetriamine (TATB), 2,4,6-trinitrotoluene (TNT-I phase), and 1,1-diammo-2,2-dinitroethylene (FOX-7), systems belonging to diverse chemical classes that encompass nitramines, nitroalkanes, nitroaromatics, nitrocubanes, nitrate esters. and amino-nitro derivatives At ambient pressure, we show that the DFT-D method is capable of providing an accurate description of the crystallographic lattice parameters with error bars significantly lower than those obtained using conventional DFT Practically, for all crystals considered in this study the predicted lattice parameters are within 2% from the corresponding experimental data [alpha-RDX (1 58%), beta-HMX (0 64%). epsilon-HNIW (1 42%), NM (0.75%), DNCP (1 99%), TATB (1.74%), TNT-I (0 92%), PNC(0.78%), PETN(1.35%), FOX-7(1.57%)1, with the best level of agreement being found for systems where experimental data have been collected at low temperatures A similar good agreement of the predicted and experimental crystallographic parameters was obtained under hydrostatic compression conditions as demonstrated for the cases of RDX, HMX. CL20, NM, TATB, and PETN crystals These results indicate that the DFT-D method provides significant improvements for description of intermolecular interactions in molecular crystals at both ambient and high pressures relative to conventional DFT. In this last case, large errors of the predicted lattice parameters have been found at low pressures; theoretical values approach the experimental results only at pressures in excess of 6 GPa
C1 [Sorescu, Dan C.] Natl Energy Technol Lab, US Dept Energy, Pittsburgh, PA 15236 USA.
[Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Sorescu, DC (reprint author), Natl Energy Technol Lab, US Dept Energy, Pittsburgh, PA 15236 USA.
NR 65
TC 86
Z9 92
U1 5
U2 70
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD APR 15
PY 2010
VL 114
IS 14
BP 6734
EP 6748
DI 10.1021/jp100379a
PG 15
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 579BP
UT WOS:000276341700074
ER
PT J
AU Wolinsky, MA
Swenson, JB
Litchfield, N
McNinch, JE
AF Wolinsky, M. A.
Swenson, J. B.
Litchfield, N.
McNinch, J. E.
TI Coastal progradation and sediment partitioning in the Holocene Waipaoa
Sedimentary System, New Zealand
SO MARINE GEOLOGY
LA English
DT Article
DE deltas; accommodation; sediment budget; shoreline trajectory;
autostratigraphy; inverse modeling
ID GRAVEL-BED RIVER; NORTH-ISLAND; POVERTY BAY; CONTINENTAL-MARGIN;
EAST-COAST; SEA-LEVEL; SHORELINE; TRANSPORT; STRATIGRAPHY; ACCRETION
AB Over the late Holocene highstand, the shoreline at Poverty Bay, NZ migrated 12 km seaward, fed by sediment from the Waipaoa river. Paleo-shorelines indicate steadily decelerating progradation, possibly signaling changes in forcing on the Waipaoa Sedimentary System. To isolate the cause of this progradation slowdown we reconstruct late Holocene tectonics and stratigraphy over the Waipaoa coastal plain and nearshore from 7 ka-present. We find that decreasing rates of sediment storage by coastal progradation were driven by increasing tectonic storage in the steadily subsiding but rapidly growing coastal plain, such that net terrestrial storage remained constant at similar to 0.8 Mt/yr. Hence changes in shoreline migration were due to autogenic increases in accommodation rather than allogenic changes in forcing. Furthermore, while the Waipaoa sediment load is primarily mud, reconstructions suggest that progradation was largely controlled by the supply of coarse-grained sediment. Our results suggest that in coastal systems such as the Waipaoa, where progradation is confined and wave energy is high, net accumulation of muds occurs only behind the prograding sandy shoreface, which shelters them from wave attack. Accounting for mud storage in the Waipaoa coastal plain and Poverty Bay suggests that export of muddy sediment to the Waipaoa shelf remained roughly constant at similar to 2.0 Mt/yr from 7 ka until the onset of anthropogenic deforestation in the 19th century. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Wolinsky, M. A.] St Anthony Falls Lab, Minneapolis, MN 55414 USA.
[Swenson, J. B.] Univ Minnesota, Dept Geol Sci, Duluth, MN 55812 USA.
[Litchfield, N.] GNS Sci, Lower Hutt, New Zealand.
[McNinch, J. E.] USACE Field Res Facil, Duck, NC 27949 USA.
[McNinch, J. E.] Virginia Inst Marine Sci, Gloucester Point, VA 23062 USA.
[McNinch, J. E.] Coll William & Mary, Gloucester Point, VA 23062 USA.
RP Wolinsky, MA (reprint author), Shell Bellaire Technol Ctr, 3737 Bellaire Blvd, Houston, TX 77025 USA.
EM Matthew.Wolinsky@shell.com
NR 53
TC 18
Z9 18
U1 0
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0025-3227
J9 MAR GEOL
JI Mar. Geol.
PD APR 15
PY 2010
VL 270
IS 1-4
SI SI
BP 94
EP 107
DI 10.1016/j.margeo.2009.10.021
PG 14
WC Geosciences, Multidisciplinary; Oceanography
SC Geology; Oceanography
GA 576IF
UT WOS:000276137100008
ER
PT J
AU Litchinitser, N
Scalora, M
AF Litchinitser, Natalia
Scalora, Michael
TI Special Issue Nonlinear Optics in Metamaterials
SO OPTICS COMMUNICATIONS
LA English
DT Editorial Material
ID NEGATIVE-INDEX
C1 [Litchinitser, Natalia] SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA.
[Scalora, Michael] USA, Charles M Bowden Res Facil, AMRDEC, RDECOM,AMSRD,AMR,WS,ST, Redstone Arsenal, AL 35898 USA.
RP Litchinitser, N (reprint author), SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA.
EM natashal@buffalo.edu
NR 4
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0030-4018
J9 OPT COMMUN
JI Opt. Commun.
PD APR 15
PY 2010
VL 283
IS 8
SI SI
BP 1579
EP 1580
DI 10.1016/j.optcom.2010.01.001
PG 2
WC Optics
SC Optics
GA 570TR
UT WOS:000275701500001
ER
PT J
AU Wang, LJ
Xu, ZY
Sadler, BM
AF Wang, Leijie
Xu, Zhengyuan
Sadler, Brian M.
TI Non-line-of-sight ultraviolet link loss in noncoplanar geometry
SO OPTICS LETTERS
LA English
DT Article
ID COMMUNICATION; PERFORMANCE
AB Various path loss models have been developed for solar blind non-line-of-sight UV communication links under an assumption of coplanar source beam axis and receiver pointing direction. This work further extends an existing single-scattering coplanar analytical model to noncoplanar geometry. The model is derived as a function of geometric parameters and atmospheric characteristics. Its behavior is numerically studied in different noncoplanar geometric settings. (C) 2010 Optical Society of America
C1 [Wang, Leijie; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA.
[Sadler, Brian M.] USA, Res Lab, RDRL CIN T, Adelphi, MD 20783 USA.
RP Xu, ZY (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA.
EM dxu@ee.ucr.edu
FU US Army Research Office (USARO) [W911NF-09-1-0293]; US Army Research
Laboratory (USARL) [DAAD1901-2-0011]
FX This work was supported by US Army Research Office (USARO) grant
W911NF-09-1-0293 and US Army Research Laboratory (USARL) grant
DAAD1901-2-0011.
NR 8
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U1 1
U2 3
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
J9 OPT LETT
JI Opt. Lett.
PD APR 15
PY 2010
VL 35
IS 8
BP 1263
EP 1265
PG 3
WC Optics
SC Optics
GA 585WN
UT WOS:000276861100050
PM 20410987
ER
PT J
AU Vasic, R
Sadowski, JT
Choi, YJ
Zhou, HD
Wiebe, CR
Cheong, SW
Rowe, JE
Ulrich, MD
AF Vasic, R.
Sadowski, J. T.
Choi, Y. J.
Zhou, H. D.
Wiebe, C. R.
Cheong, S. W.
Rowe, J. E.
Ulrich, M. D.
TI Surface reconstruction of hexagonal Y-doped HoMnO3 and LuMnO3 studied
using low-energy electron diffraction
SO PHYSICAL REVIEW B
LA English
DT Article
ID MANGANITES; YMNO3; SRTIO3(100); PEROVSKITES; TRANSITION
AB We have investigated the (0001) surfaces of several hexagonal manganite perovskites by low-energy electron diffraction (LEED) in order to determine if the surface periodicity is different from that of the bulk materials. These LEED studies were conducted using near-normal incidence geometry with a low energy electron microscope (LEEM)/LEED apparatus from room temperature to 1200 degrees C and with an electron energy in the range of 15-50 eV. Diffraction patterns showed features of bulk-terminated periodicity as well as a 2 x 2 surface reconstruction. Possible origins for this surface reconstruction structure are discussed and comparisons are made with surface studies of other complex oxides.
C1 [Vasic, R.] Yeshiva Univ, Dept Phys, New York, NY 10033 USA.
[Sadowski, J. T.] Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA.
[Choi, Y. J.; Cheong, S. W.] Rutgers State Univ, Dept Phys & Astron, Piscataway, NJ 08854 USA.
[Zhou, H. D.; Wiebe, C. R.] Florida State Univ, Condensed Matter Grp Expt, NHMFL, Tallahassee, FL 32310 USA.
[Rowe, J. E.; Ulrich, M. D.] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA.
[Ulrich, M. D.] USA, Res Off, Div Phys, Res Triangle Pk, NC 27709 USA.
RP Vasic, R (reprint author), Yeshiva Univ, Dept Phys, New York, NY 10033 USA.
RI Zhou, Haidong/O-4373-2016;
OI Sadowski, Jerzy/0000-0002-4365-7796
FU U.S. Department of Energy (DOE), Office of Basic Energy Sciences (BES)
[DE-FG02-07ER46382, DE-AC02-98CH10886]; National Science Foundation
through NSF [DMR0449569]; State of Florida
FX We acknowledge Army Research Office for support for this research. Work
at Rutgers was supported by U.S. Department of Energy (DOE), Office of
Basic Energy Sciences (BES) DE-FG02-07ER46382. The NHMFL is supported by
contractual agreement between the National Science Foundation through
NSF under Grant No. DMR0449569 and the State of Florida. Research
carried out in part at the Center for Functional Nanomaterials,
Brookhaven National Laboratory, which is supported by the DOE BES, under
Contract No. DE-AC02-98CH10886. The National Synchrotron Light Source,
Brookhaven National Laboratory, is supported by the DOE BES, under
Contract No. DE-AC02-98CH10886.
NR 32
TC 0
Z9 0
U1 0
U2 22
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1098-0121
J9 PHYS REV B
JI Phys. Rev. B
PD APR 15
PY 2010
VL 81
IS 16
AR 165417
DI 10.1103/PhysRevB.81.165417
PG 6
WC Physics, Condensed Matter
SC Physics
GA 590HX
UT WOS:000277217200094
ER
PT J
AU Pang, YP
Davis, J
Wang, SH
Park, JG
Nambiar, MP
Schmidt, JJ
Millard, CB
AF Pang, Yuan-Ping
Davis, Jon
Wang, Shaohua
Park, Jewn Giew
Nambiar, Madhusoodana P.
Schmidt, James J.
Millard, Charles B.
TI Small Molecules Showing Significant Protection of Mice against Botulinum
Neurotoxin Serotype A
SO PLOS ONE
LA English
DT Article
ID AB-INITIO CALCULATIONS; DYNAMICS SIMULATION; ZINC ENDOPEPTIDASE; TOXIN;
INHIBITORS; IDENTIFICATION; AMBER; RECOGNITION; PERFORMANCE; MANAGEMENT
AB Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism that could afflict large, unprotected populations if the toxin were employed in an act of bioterrorism. Current post-exposure therapy is limited to symptomatic treatment or passive immunization that is effective for treating infant botulism at a cost of US $45,300 per treatment regimen. Antibodies can neutralize the extracellular but not the intracellular BoNTA. Moreover, antibody production, storage, and administration in a mass casualty scenario pose logistical challenges. Alternatively, small-molecule inhibitors of BoNTA endopeptidase (BoNTAe) are sought to antagonize the extracellular or intracellular toxin. While several such molecules reportedly demonstrated efficacy in protecting cells against BoNTA, there is scant information to show that small molecules can significantly protect mammals against BoNTA. Herein we report the development of effective small-molecules BoNTAe inhibitors with promising in vivo pharmacokinetics. One such molecule has an in vivo half-life of 6.5 hours and is devoid of obvious sign of toxicity. Pre-treatment with this molecule at 2 mg/kg protected 100% and 70% of treated mice against BoNTA at 5 times of its median-lethal dose during the periods of 2 and 4 half-lives of the inhibitor, respectively. In contrast, 40% and 0% of untreated mice survived during the respective periods. Similar levels of protection were also observed with two other small molecules. These results demonstrate that small molecules can significantly protect mice against BoNTA and support the pursuit of small-molecule antagonists as a cost-effective alternative or as an adjunct to passive immunity for treating botulism.
C1 [Pang, Yuan-Ping; Wang, Shaohua; Park, Jewn Giew] Mayo Clin, Comp Aided Mol Design Lab, Rochester, MN 55905 USA.
[Davis, Jon; Nambiar, Madhusoodana P.; Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD USA.
[Schmidt, James J.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA.
RP Pang, YP (reprint author), Mayo Clin, Comp Aided Mol Design Lab, Rochester, MN 55905 USA.
EM pang@mayo.edu; charles.b.millard@us.army.mil
OI Pang, Yuan-Ping/0000-0003-0838-2560
FU United States Army Medical Research and Materiel Command
[W81XWH-04-2-0001, W81XWH-08-1-0154]; United States Army Research Office
[W911NF-09-1-0095]; United States Defense Threat Reduction Agency
[3.10023_07_RD_B, 3.10014_08_WR_B]; University of Minnesota
Supercomputing Institute
FX This work was supported by the United States Army Medical Research and
Materiel Command (W81XWH-04-2-0001 and W81XWH-08-1-0154), the United
States Army Research Office (W911NF-09-1-0095), the United States
Defense Threat Reduction Agency (3.10023_07_RD_B and 3.10014_08_WR_B),
and the University of Minnesota Supercomputing Institute. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript. The opinions and assertions
contained herein are the private views of the authors and are not to be
construed as official or as reflecting the views of the United States
Army, Navy or the Department of Defense.
NR 45
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U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 13
PY 2010
VL 5
IS 4
AR e10129
DI 10.1371/journal.pone.0010129
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 583UV
UT WOS:000276706300002
PM 20405003
ER
PT J
AU Fazio, E
Belardini, A
Alonzo, M
Centini, M
Chauvet, M
Devaux, F
Scalora, M
AF Fazio, Eugenio
Belardini, Alessandro
Alonzo, Massimo
Centini, Marco
Chauvet, Mathieu
Devaux, Fabrice
Scalora, Michael
TI Observation of photorefractive simultons in lithium niobate
SO OPTICS EXPRESS
LA English
DT Article
ID DISPERSIVE DIELECTRIC FIBERS; NONLINEAR OPTICAL PULSES; 2ND-HARMONIC
GENERATION; QUADRATIC MEDIUM; SOLITARY WAVES; STEADY-STATE; SOLITONS;
BEAM; TRANSMISSION; BOUNDARY
AB Spatial and temporal locking of fundamental and second harmonic pulses was realized by means of photorefractive nonlinearity and highly mismatched harmonic generation. Due to the presence of both phase-locked and unlocked second harmonic pulses, a twin simultonic state was observed. Simultonic filamentation occurring at high pumping rates allowed us to determine a relation between the simulton's waist and its intensity. (C) 2010 Optical Society of America
C1 [Fazio, Eugenio; Belardini, Alessandro; Alonzo, Massimo; Centini, Marco] Univ Roma La Sapienza, Dipartimento Energet, Ultrafast Photon Lab, I-00161 Rome, Italy.
[Fazio, Eugenio; Belardini, Alessandro; Alonzo, Massimo; Centini, Marco] Univ Roma La Sapienza, CNISM, I-00161 Rome, Italy.
[Chauvet, Mathieu; Devaux, Fabrice] Univ Franche Comte, CNRS, UMR 6174, Inst FEMTO ST,Dept Opt, F-25030 Besancon, France.
[Scalora, Michael] USA, Aviat & Missile Command, RDECOM, Charles M Bowden Res Facil, Redstone Arsenal, AL 35803 USA.
RP Fazio, E (reprint author), Univ Roma La Sapienza, Dipartimento Energet, Ultrafast Photon Lab, Via Scarpa 16, I-00161 Rome, Italy.
EM eugenio.fazio@uniroma1.it
RI devaux, fabrice/A-9231-2013;
OI BELARDINI, ALESSANDRO/0000-0002-7574-0332; CENTINI,
MARCO/0000-0003-0625-0054; FAZIO, Eugenio/0000-0002-0995-0702
FU Sapienza Universita di Roma
FX This work has been supported by the contracts from Sapienza Universita
di Roma A) ricerche universitarie 2007(processi ottici nonlineari di
generazione di armonica in materiali massivi e nanostrutturati altamente
dispersivi) and B) ricerche di ateneo federato 2008 (generazione di
seconda armonica in sistemi dispersivi e nano strutturati). E. F. is
grateful to the Universite de Franche Comte for the visiting
professorship under which part of this work has been performed. A. M. D.
G.
NR 27
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U1 0
U2 3
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD APR 12
PY 2010
VL 18
IS 8
BP 7972
EP 7981
DI 10.1364/OE.18.007972
PG 10
WC Optics
SC Optics
GA 582PP
UT WOS:000276610300045
PM 20588640
ER
PT J
AU Hrozhyk, UA
Serak, SV
Tabiryan, NV
Hoke, L
Steeves, DM
Kimball, BR
AF Hrozhyk, Uladzimir A.
Serak, Svetlana V.
Tabiryan, Nelson V.
Hoke, Landa
Steeves, Diane M.
Kimball, Brian R.
TI Azobenzene liquid crystalline materials for efficient optical switching
with pulsed and/or continuous wave laser beams
SO OPTICS EXPRESS
LA English
DT Article
ID PHOTOISOMERIZATION; FULLERENES; SENSOR; STATE; FILMS
AB This study compares optical switching capabilities of liquid crystal (LC) materials based on different classes of azobenzene dyes. LCs based on molecules containing benzene rings with nearly symmetrical pi-pi conjugation respond more efficiently to a cw beam than to a nanosecond laser pulse and maintain the changes induced by the beam for tens of hours. Using azo dye molecules containing two benzene rings with push-pull pi-pi conjugation we demonstrate high photosensitivity to both a cw beam as well as nanosecond laser pulse with only 1 s relaxation of light-induced changes in material properties. Even faster, 1 ms restoration time is obtained for azo dye molecules containing hetaryl (benzothiazole) ring with enhanced pushpull pi-pi conjugation. These materials respond most efficiently to pulsed excitation while discriminating cw radiation. 2010 Optical Society of America
C1 [Hrozhyk, Uladzimir A.; Serak, Svetlana V.; Tabiryan, Nelson V.] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA.
[Hoke, Landa; Steeves, Diane M.; Kimball, Brian R.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Hrozhyk, UA (reprint author), Beam Engn Adv Measurements Co, 809 S Orlando Ave,Suite I, Winter Pk, FL 32789 USA.
EM brian.r.kimball@us.army.mil
NR 27
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U1 1
U2 22
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD APR 12
PY 2010
VL 18
IS 8
BP 8697
EP 8704
DI 10.1364/OE.18.008697
PG 8
WC Optics
SC Optics
GA 582PP
UT WOS:000276610300118
PM 20588713
ER
PT J
AU Cerco, CF
Noel, MR
AF Cerco, Carl F.
Noel, Mark R.
TI Monitoring, modeling, and management impacts of bivalve filter feeders
in the oligohaline and tidal fresh regions of the Chesapeake Bay system
SO ECOLOGICAL MODELLING
LA English
DT Article
DE Chesapeake Bay; Potomac River; Eutrophication model; Rangia cuneata;
Corbicula fluminea
ID CORBICULA-FLUMINEA BIVALVIA; ASIATIC CLAM; POTOMAC RIVER;
EUTROPHICATION; PHYTOPLANKTON; DYNAMICS; SEDIMENT; MARYLAND; ESTUARY;
GROWTH
AB Populations of bivalve filter feeders are distributed throughout the oligohaline waters of the Chesapeake Bay system and, to a lesser extent, in tidal fresh waters as well. Previous studies indicate these bivalves significantly diminish phytoplankton concentrations in one major tributary, the Potomac River, and observed chlorophyll concentrations suggest bivalve influence on phytoplankton in other oligohaline reaches. We incorporated a model of these bivalves into an existing eutrophication model of the system. The model indicated that bivalves may reduce phytoplankton concentrations in oligohaline and tidal fresh waters throughout the system but the most significant effects were noted in the Potomac and Patuxent tributaries. Bivalve impacts were related to hydraulic residence time. The greatest phytoplankton reductions occurred in the regions with the longest residence time. Model carbon and nutrient budgets indicated bivalves removed 14% to 40% of the carbon load, 11% to 23% of the nitrogen load, and 37% to 84% of the phosphorus load to the regions where their impact on computed chlorophyll was greatest. Published by Elsevier B.V.
C1 [Cerco, Carl F.; Noel, Mark R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Cerco, CF (reprint author), USA, Engineer Res & Dev Ctr, Mail Stop EP-W,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM carl.f.cerco@usace.army.mil
NR 33
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U1 4
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3800
J9 ECOL MODEL
JI Ecol. Model.
PD APR 10
PY 2010
VL 221
IS 7
BP 1054
EP 1064
DI 10.1016/j.ecolmodel.2009.07.024
PG 11
WC Ecology
SC Environmental Sciences & Ecology
GA 572DT
UT WOS:000275808200010
ER
PT J
AU Wang, Y
Li, YS
Lucca, SLD
Simovic, M
Tsokos, GC
Lucca, JJD
AF Wang, Ying
Li, Yansong
Lucca, Shawn L. Dalle
Simovic, Milomir
Tsokos, George C.
Lucca, Jurandir J. Dalle
TI Decay accelerating factor (CD55) protects neuronal cells from chemical
hypoxia-induced injury
SO JOURNAL OF NEUROINFLAMMATION
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; MEMBRANE ATTACK COMPLEX; CENTRAL-NERVOUS-SYSTEM;
D-ASPARTATE RECEPTOR; TYROSINE PHOSPHORYLATION; CEREBRAL-ISCHEMIA;
DENDRITIC SPINES; DIFFERENT MODES; ACTIVATION; SRC
AB Background: Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy for the management of ischemic brain injury. Decay-accelerating factor (DAF, also known as CD55) inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. The present study investigates the ability of DAF to protect primary cultured neuronal cells subjected to sodium cyanide (NaCN)-induced hypoxia from degeneration and apoptosis.
Methods: Cultured primary cortical neurons from embryonic Sprague-Dawley rats were assigned one of four groups: control, DAF treatment alone, hypoxic, or hypoxic treated with DAF. Hypoxic cultures were exposed to NaCN for 1 hour, rinsed, followed by 24 hour exposure to 200 ng/ml of recombinant human DAF in normal medium. Human DAF was used in the present study and it has been shown to effectively regulate complement activation in rats. Neuronal cell function, morphology and viability were investigated by measuring plateau depolarization potential, counting the number dendritic spines, and observing TUNEL and MTT assays. Complement C3, C3a, C3a receptor (R) production, C3a-C3aR interaction and MAC formation were assessed along with the generation of activated caspase-9, activated caspase-3, and activated Src.
Results: When compared to controls, hypoxic cells had fewer dendritic spines, reduced plateau depolarization accompanied by increased apoptotic activity and accumulation of MAC, as well as up-regulation of C3, C3a and C3aR, enhancement of C3a-C3aR engagement, and elevated caspase and Src activity. Treatment of hypoxic cells with 200 ng/ml of recombinant human DAF resulted in attenuation of neuronal apoptosis and exerted significant protection against neuronal dendritic spine loss and plateau depolarization reduction. Furthermore, treatment with DAF resulted in decreased accumulation of C3a, MAC, C3a-C3aR interaction, caspase-9, activated caspase-3, and pTyr416-Src (activated Src) tyrosine kinase.
Conclusion: DAF was found to reduce neuronal cell death and apoptosis in NaCN induced hypoxia. This effect is attributed to the ability of DAF to limit complement activation and inhibit the activity of Src and caspases 9 and 3. This study supports the inhibiting of complement as a neuroprotective strategy against CNS ischemia/reperfusion injury.
C1 [Wang, Ying; Li, Yansong; Simovic, Milomir; Lucca, Jurandir J. Dalle] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA.
[Lucca, Shawn L. Dalle] Clin Res Management Inc, Frederick, MD 21701 USA.
[Tsokos, George C.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA.
RP Lucca, JJD (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA.
EM jurandir.dallelucca@us.army.mil
FU Department of Defense; Army Technology Objective for Damage Control
Resuscitation
FX The authors wish to thank Dr. Feng Yang for the whole cell recordings
and scientific consultation, Dr. Yuanyuan Ji for technical expertise in
primary neuronal culture, and the Department of Defense Combat Casualty
Care Research Program and Army Technology Objective for Damage Control
Resuscitation for supporting this work.
NR 53
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U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD APR 9
PY 2010
VL 7
AR 24
DI 10.1186/1742-2094-7-24
PG 13
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA 595SL
UT WOS:000277633300001
PM 20380727
ER
PT J
AU Crum-Cianflone, N
Roediger, MP
Eberly, L
Headd, M
Marconi, V
Ganesan, A
Weintrob, A
Barthel, RV
Fraser, S
Agan, BK
AF Crum-Cianflone, Nancy
Roediger, Mollie Poehlman
Eberly, Lynn
Headd, Maryam
Marconi, Vincent
Ganesan, Anuradha
Weintrob, Amy
Barthel, R. Vincent
Fraser, Susan
Agan, Brian K.
CA Infect Dis Clinical Res Program HI
TI Increasing Rates of Obesity among HIV-Infected Persons during the HIV
Epidemic
SO PLOS ONE
LA English
DT Article
ID ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS;
WEIGHT-LOSS; BODY-COMPOSITION; COHORT; RISK; ERA; OVERWEIGHT; SURVIVAL;
ADULTS
AB Background: The prevalence and factors associated with overweight/obesity among human immunodeficiency virus (HIV)-infected persons are unknown.
Methods: We evaluated prospective data from a U. S. Military HIV Natural History Study (1985-2004) consisting of early diagnosed patients. Statistics included multivariate linear regression and longitudinal linear mixed effects models.
Results: Of 1682 patients, 2% were underweight, 37% were overweight, and 9% were obese at HIV diagnosis. Multivariate predictors of a higher body mass index (BMI) at diagnosis included more recent year of HIV diagnosis, older age, African American race, and earlier HIV stage (all p < 0.05). The majority of patients (62%) gained weight during HIV infection. Multivariate factors associated with a greater increase in BMI during HIV infection included more recent year of diagnosis, lower BMI at diagnosis, higher CD4 count, lower HIV RNA level, lack of AIDS diagnosis, and longer HIV duration (all p < 0.05). Nucleoside agents were associated with less weight gain; other drug classes had no significant impact on weight change in the HAART era.
Conclusions: HIV-infected patients are increasingly overweight/obese at diagnosis and during HIV infection. Weight gain appears to reflect improved health status and mirror trends in the general population. Weight management programs may be important components of HIV care.
C1 [Crum-Cianflone, Nancy; Roediger, Mollie Poehlman; Eberly, Lynn; Marconi, Vincent; Ganesan, Anuradha; Weintrob, Amy; Barthel, R. Vincent; Fraser, Susan; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Crum-Cianflone, Nancy] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92152 USA.
[Crum-Cianflone, Nancy; Headd, Maryam] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA.
[Roediger, Mollie Poehlman; Eberly, Lynn] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
[Marconi, Vincent] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA.
[Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA.
[Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA.
[Barthel, R. Vincent] USN, Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA.
[Fraser, Susan] Tripler Med Ctr, Infect Dis Clin, Honolulu, HI USA.
RP Crum-Cianflone, N (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
EM nancy.crum@med.navy.mil
RI Marconi, Vincent/N-3210-2014;
OI Marconi, Vincent/0000-0001-8409-4689; Eberly, Lynn/0000-0003-4763-330X;
Agan, Brian/0000-0002-5114-1669
FU Infectious Disease Clinical Research Program (IDCRP); Department of
Defense (DoD); National Institute of Allergy and Infectious Diseases,
National Institutes of Health (NIH) [Y1-AI-5072]
FX Support for this work was provided by the Infectious Disease Clinical
Research Program (IDCRP), a Department of Defense (DoD) program executed
through the Uniformed Services University of the Health Sciences. This
project has been funded in whole, or in part, with federal funds from
the National Institute of Allergy and Infectious Diseases, National
Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 40
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U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 9
PY 2010
VL 5
IS 4
AR e10106
DI 10.1371/journal.pone.0010106
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 580WU
UT WOS:000276482100019
PM 20419086
ER
PT J
AU Kelly, EP
Puri, B
Sun, W
Falgout, B
AF Kelly, Eileen P.
Puri, Beena
Sun, Wellington
Falgout, Barry
TI Identification of mutations in a candidate dengue 4 vaccine strain
341750 PDK20 and construction of a full-length cDNA clone of the PDK20
vaccine candidate
SO VACCINE
LA English
DT Article
DE Dengue virus; Vaccine virus mutation analysis; Infectious clone
ID BORNE ENCEPHALITIS-VIRUS; HEPATITIS-C VIRUS; AMINO-ACID SUBSTITUTION;
DOUBLE-STRANDED-RNA; ENVELOPE PROTEIN; VIRAL-RNA; HEMORRHAGIC-FEVER;
CRYSTAL-STRUCTURE; NS1 PROTEIN; NONSTRUCTURAL GLYCOPROTEIN-NS1
AB Dengue 4 virus strain 341750 serially passaged 20 times in primary dog kidney (PDK) cells was shown to have reduced infectivity for rhesus monkeys but was immunogenic and protected the monkeys from challenge with low passage parent dengue 4 virus. The dengue 4 PDK20 virus was also shown to be attenuated for human volunteers. We compared the genomic nucleotide sequences of low passage parent and PDK20 attenuated vaccine strains and identified 11 nucleotide (nt) substitutions in the PDK20 genome. Five mutations caused amino acid changes in viral proteins E (N366N/S), NS1 (E146Q), NS4B (S/L112L and A240V), and NS5 (F/L790L). Silent mutations occurred in genes encoding NS1 (nt 2609), NS3 (nt 6113, 6230 and 6239) and NS5 (nt 8081 and 8588). A full-length cDNA clone of the dengue 4 strain 341750 PDK20 was constructed and RNA transcripts of the clone were infectious in monkey kidney (LLC-MK(2)) and Aedes albopictus (C6/36) cells. The sequence analysis and availability of an infectious clone provide molecular tools to investigate the basis for the attenuation of dengue 4 virus. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Kelly, Eileen P.; Sun, Wellington] Walter Reed Army Inst Res, Div Virus Dis, Dept Virus Dis, Silver Spring, MD 20910 USA.
[Puri, Beena] USN, Dept Infect Dis, Viral Dis Program, Med Res Ctr, Silver Spring, MD USA.
[Falgout, Barry] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20952 USA.
RP Kelly, EP (reprint author), Walter Reed Army Inst Res, Div Virus Dis, Dept Virus Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM eileen.kelly@amedd.army.mil; beena.puri@fda.hhs.gov;
wellington.sun@fda.hhs.gov; barry.falgout@fda.hhs.gov
FU United States Army Medical Research and Materiel Command
FX We thank Dr. Ken Eckels, Walter Reed Army Institute of Research, for
providing the lyophilized parent and vaccine candidate viruses. The
studies were supported by the United States Army Medical Research and
Materiel Command.
NR 53
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U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD APR 9
PY 2010
VL 28
IS 17
BP 3030
EP 3037
DI 10.1016/j.vaccine.2009.10.084
PG 8
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 586CE
UT WOS:000276877900016
PM 19874927
ER
PT J
AU Sloan, SD
Tsoflias, GP
Steeples, DW
AF Sloan, Steven D.
Tsoflias, Georgios P.
Steeples, Don W.
TI Ultra-shallow seismic imaging of the top of the saturated zone
SO GEOPHYSICAL RESEARCH LETTERS
LA English
DT Article
ID WATER-TABLE; REFLECTION; AQUIFER
AB We collected ultra-shallow seismic-reflection data to image the near-surface stratigraphy of a Kansas River point bar. We were successful in identifying a discontinuous clay layer and the top of the saturated zone at depths of 0.95 and 1.4 m. Seismic walkaway data collected using various .22-caliber ammunition show that decreased source energy is necessary to generate higher frequencies and prevent clipping of critical near-offset traces needed to identify ultra-shallow reflections. The seismic reflections exhibited average normal moveout velocities of 180-195 m/s with dominant frequencies of 200-450 Hz. Coincident subsurface features were also imaged using 200-MHz ground-penetrating radar. This study presents the shallowest seismic reflection from the top of the saturated zone reported in the literature to date and further demonstrates the potential of using seismic-reflection methods for ultra-shallow imaging of the subsurface as a stand-alone tool or in conjunction with other high-resolution geophysical techniques. Citation: Sloan, S. D., G. P. Tsoflias, and D. W. Steeples (2010), Ultra-shallow seismic imaging of the top of the saturated zone, Geophys. Res. Lett., 37, L07405, doi:10.1029/2010GL043034.
C1 [Sloan, Steven D.] USA, Corps Engineers, Engineer Res & Dev Ctr, CEERD GS S, Vicksburg, MS 39180 USA.
[Tsoflias, Georgios P.; Steeples, Don W.] Univ Kansas, Dept Geol, Lawrence, KS 66045 USA.
RP Sloan, SD (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, CEERD GS S, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM steven.d.sloan@usace.army.mil; tsoflias@ku.edu; don@ku.edu
NR 11
TC 1
Z9 1
U1 0
U2 7
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0094-8276
J9 GEOPHYS RES LETT
JI Geophys. Res. Lett.
PD APR 8
PY 2010
VL 37
AR L07405
DI 10.1029/2010GL043034
PG 5
WC Geosciences, Multidisciplinary
SC Geology
GA 581SN
UT WOS:000276544900008
ER
PT J
AU Wagner, GW
Procell, LR
Sorrick, DC
Lawson, GE
Wells, CM
Reynolds, CM
Ringelberg, DB
Foley, KL
Lumetta, GJ
Blanchard, DL
AF Wagner, George W.
Procell, Lawrence R.
Sorrick, David C.
Lawson, Glenn E.
Wells, Claire M.
Reynolds, Charles M.
Ringelberg, David B.
Foley, Karen L.
Lumetta, Gregg J.
Blanchard, David L., Jr.
TI All-Weather Hydrogen Peroxide-Based Decontamination of CBRN Contaminants
SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
LA English
DT Article
ID CHROMATOGRAPHY MASS-SPECTROMETRY; CHEMICAL WARFARE SAMPLES; NERVE AGENT
VX; DEGRADATION-PRODUCTS; SULFUR MUSTARD; DETOXIFICATION; OXIDATION;
SARIN
AB A hydrogen peroxide-based decontaminant, Decon Green, is efficacious for the decontamination of chemical agents VX (S-2-(diisopropylamino)ethyl O-ethyl methylphosphonothioate), GD (Soman, pinacolyl methylphosphonofluoridate), and HD (mustard, bis(2-chloroethyl) sulfide); the biological agent anthrax (Bacillus anthracis); and radiological isotopes (137)Cs and (60)Co; thus demonstrating the ability of this decontamination approach to ameliorate the aftermath of all three types of weapons of mass destruction (WMD). Reaction mechanisms afforded for the chemical agents are discussed as are rationales for the enhanced removal efficacy of recalcitrant (60)Co on certain surfaces. Decontaminants of this nature can be deployed, and are effective, at very low temperatures (-32 degrees C), as shown for studies done with VX and HD simulants, without the need for external heat sources. Finally, the efficacy of a lower-logistics, dry decontaminant powder concentrate (utilizing the solid active-oxygen compounds peracetyl borate and Peroxydone) which can be reconstituted with water in the field prior to use, is presented.
C1 [Wagner, George W.; Procell, Lawrence R.; Sorrick, David C.] USA, ECBC, Aberdeen Proving Ground, MD 21010 USA.
[Lawson, Glenn E.; Wells, Claire M.] USN, Ctr Surface Warfare, Dahlgren, VA 22448 USA.
[Reynolds, Charles M.; Ringelberg, David B.; Foley, Karen L.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Lumetta, Gregg J.; Blanchard, David L., Jr.] Pacific NW Natl Lab, Richland, WA 99352 USA.
RP Wagner, GW (reprint author), USA, ECBC, Aberdeen Proving Ground, MD 21010 USA.
EM george.wagner@us.army.mil
FU Defense Threat Reduction Agency (DTRA) [CDEC3007, BA06DEC052];
[206023.84BP0]
FX The many participants who contributed to this work can be found in the
references to the prior work, and they are gratefully acknowledged for
their technical and experimental endeavors. Support of this work was
provided under Project Nos. 206023.84BP0 and CDEC3007, and Defense
Threat Reduction Agency (DTRA) Projects CDEC3007 and BA06DEC052.
NR 39
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U1 2
U2 39
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0888-5885
J9 IND ENG CHEM RES
JI Ind. Eng. Chem. Res.
PD APR 7
PY 2010
VL 49
IS 7
BP 3099
EP 3105
DI 10.1021/ie9019177
PG 7
WC Engineering, Chemical
SC Engineering
GA 574TI
UT WOS:000276016100008
ER
PT J
AU Dmytriiev, O
Meitzler, T
Bankowski, E
Slavin, A
Tiberkevich, V
AF Dmytriiev, O.
Meitzler, T.
Bankowski, E.
Slavin, A.
Tiberkevich, V.
TI Spin wave excitations of a magnetic pillar with dipolar coupling between
the layers
SO JOURNAL OF PHYSICS-CONDENSED MATTER
LA English
DT Article
AB It is demonstrated analytically that the spectrum of small-amplitude spatially uniform magnetization excitations in an in-plane magnetized magnetic pillar with two ferromagnetic layers coupled by dipole-dipole interaction can be approximately described by the traditional Kittel formula with reduced saturation magnetization and effective anisotropy field. The spectrum consists of a quasi-symmetric and a quasi-antisymmetric mode, and the apparent reduction of saturation magnetization for the quasi-symmetric mode (<= 50%) is much larger than that for the quasi-antisymmetric mode (<= 10%). The effect of dynamic dipolar coupling between the nano-pillar layers could be partly responsible for the apparent reduction of static magnetization seen in many spin-torque experiments performed on magnetic nano-pillars.
C1 [Dmytriiev, O.; Slavin, A.; Tiberkevich, V.] Oakland Univ, Dept Phys, Rochester, MI 48309 USA.
[Dmytriiev, O.] Inst Magnetism, UA-142 Kiev, Ukraine.
[Meitzler, T.; Bankowski, E.] USA, TARDEC, Warren, MI 48397 USA.
RP Dmytriiev, O (reprint author), Oakland Univ, Dept Phys, Rochester, MI 48309 USA.
EM slavin@oakland.edu; tyberkev@oakland.edu
RI Tiberkevich, Vasil/A-8697-2008; Meitzler, Thomas/D-1065-2017
OI Tiberkevich, Vasil/0000-0002-8374-2565;
FU National Science Foundation of the USA [ECCS 0653901]; US Army TARDEC,
RDECOM [W56HZW-09-P-L564]; US Army Research Office (MURI)
[W911NF-04-1-0247]
FX We acknowledge support from the National Science Foundation of the USA
(grant No. ECCS 0653901), from the US Army TARDEC, RDECOM (contract N0.
W56HZW-09-P-L564), and from the US Army Research Office (MURI grant No.
W911NF-04-1-0247).
NR 13
TC 20
Z9 20
U1 0
U2 4
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0953-8984
J9 J PHYS-CONDENS MAT
JI J. Phys.-Condes. Matter
PD APR 7
PY 2010
VL 22
IS 13
AR 136001
DI 10.1088/0953-8984/22/13/136001
PG 6
WC Physics, Condensed Matter
SC Physics
GA 570MS
UT WOS:000275683000017
PM 21389519
ER
PT J
AU Cureton, LT
Beyer, FL
Turner, SR
AF Cureton, LaShonda T.
Beyer, Frederick L.
Turner, S. Richard
TI Synthesis and characterization of hexafluoroisopropylidene bisphenol
poly(arylene ether sulfone) and polydimethylsiloxane segmented block
copolymers
SO POLYMER
LA English
DT Article
DE Poly(arylene ether sulfone); Segmented block copolymer; Morphology
ID POLYURETHANE ELASTOMERS; MULTIBLOCK COPOLYMERS; MEMBRANES; MORPHOLOGY;
POLYMERS; SERIES; POLYSTYRENE; STABILITY; CARBONATE; SURFACE
AB A series of hexafluoroisopropylidene bisphenol poly(arylene ether sulfone) (BAF PAES) segmented block copolymers with varying fractions of polydimethylsiloxane (PDMS) were synthesized by a condensation reaction of hydroxyl-terminated BAF PAES and dimethylamino endcapped PDMS. The segmented block copolymers have high thermal stability. The BAF PAES homopolymer exhibits a tensile modulus of 1700 MPa and an elongation at break of 16%. Copolymerizing BAF PAES with increasing molecular weight amounts of PDMS results in tensile properties ranging from plastic to elastomeric where the elongation is 417% for a segmented block copolymer with 64 wt% PDMS incorporated. The morphological properties of these segmented block copolymers were characterized by atomic force microscopy (AFM), small-angle X-ray scattering (SAXS), and transmission electron microscopy (TEM). AFM and TEM images show the segmented block copolymers were microphase separated, and comparison with bisphenol A (BA) PAES-b-PDMS segmented block copolymers revealed complex differences between the morphological behavior of the two systems. SAXS data of the segmented block copolymers supports AFM and TEM images, indicating microphase separation but little long-range order. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Cureton, LaShonda T.; Turner, S. Richard] Virginia Polytech Inst & State Univ, Dept Chem Macromol & Interfaces Inst MII, Blacksburg, VA 24061 USA.
[Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Turner, SR (reprint author), Virginia Polytech Inst & State Univ, Dept Chem Macromol & Interfaces Inst MII, Blacksburg, VA 24061 USA.
EM srturner@vt.edu
FU Army Research Laboratory [W911NF-06-2-0014]
FX This research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-06-2-0014. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation hereon.
NR 41
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U1 3
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
J9 POLYMER
JI Polymer
PD APR 6
PY 2010
VL 51
IS 8
BP 1679
EP 1686
DI 10.1016/j.polymer.2010.02.010
PG 8
WC Polymer Science
SC Polymer Science
GA 580WR
UT WOS:000276481800003
ER
PT J
AU Lee, I
Choi, KK
Gorsich, D
AF Lee, Ikjin
Choi, K. K.
Gorsich, David
TI Sensitivity analyses of FORM-based and DRM-based performance measure
approach (PMA) for reliability-based design optimization (RBDO)
SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING
LA English
DT Article
DE sensitivity analyses; dimension reduction method (DRM); inverse
reliability analysis; first-order reliability method (FORM); performance
measure approach (PMA); most probable point (MPP) update;
reliability-based design optimization (RBDO)
ID DIMENSION-REDUCTION METHOD; MULTIDIMENSIONAL INTEGRATION; STOCHASTIC
MECHANICS
AB In gradient-based design optimization, the sensitivities of the constraint with respect to the design variables are required. In reliability-based design optimization (RBDO), the probabilistic constraint is evaluated at the most probable point (MPP), and thus the sensitivities of the probabilistic constraints at MPP are required. This paper presents the rigorous analytic derivation of the sensitivities of the probabilistic constraint at MPP for both first-order reliability method (FORM)-based performance measure approach (PMA) and dimension reduction method (DRM)-based PMA. Numerical examples are used to demonstrate that the analytic sensitivities agree very well with the sensitivities obtained from the finite difference method (FDM). However, as the sensitivity calculation at the true DRM-based MPP requires the second-order derivatives and additional MPP search, the sensitivity derivation at the approximated DRM-based MPP, which does not require the second-order derivatives and additional MPP search to find the DRM-based MPP, is proposed in this paper. A convergence study illustrates that the sensitivity at the approximated DRM-based MPP converges to the sensitivity at the true DRM-based MPP as the design approaches the optimum design. Hence, the sensitivity at the approximated DRM-based MPP is proposed to be used for the DRM-based RBDO to enhance the efficiency of the optimization. Copyright (C) 2009 John Wiley & Sons, Ltd.
C1 [Lee, Ikjin; Choi, K. K.] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA.
[Gorsich, David] USA, RDECOM TARDEC, AMSRD TAR, Warren, MI 48397 USA.
RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA.
EM kkchoi@engineering.uiowa.edu
RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008
OI Choi, Kyung/0000-0003-2384-6220
FU Automotive Research Center; U.S. Army TARDEC
FX Research is supported by the Automotive Research Center, which is
sponsored by the U.S. Army TARDEC.
NR 34
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U1 0
U2 11
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 0029-5981
J9 INT J NUMER METH ENG
JI Int. J. Numer. Methods Eng.
PD APR 2
PY 2010
VL 82
IS 1
BP 26
EP 46
DI 10.1002/nme.2752
PG 21
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications
SC Engineering; Mathematics
GA 574EM
UT WOS:000275971500002
ER
PT J
AU Behrens, DA
Lee, IC
Waits, CM
AF Behrens, Douglas A.
Lee, Ivan C.
Waits, C. Michael
TI Catalytic combustion of alcohols for microburner applications
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Alcohols; Combustion; Microburner; Reforming; Electrospray; Bio-refinery
ID PARTIAL OXIDATION; ETHANOL; FUEL; MESOSCALE; LIQUIDS
AB The combustion of energy dense liquid fuels in a catalytic micro-combustor, whose temperatures can be used in energy conversion devices, is an attractive alternative to cumbersome batteries. To miniaturize the reactor, an evaporation model was developed to calculate the minimum distance required for complete droplet vaporization. By increasing the ambient temperature from 298 to 350 K, the distance required for complete evaporation of a 6.5 mu m droplet decreases from 3.5 to 0.15 cm. A platinum mesh acted as a preliminary measurement and demonstrated 75% conversion of ethanol. We then selected a more active rhodium-coated alumina foam with a larger surface area and attained 100% conversion of ethanol and 95% conversion of 1-butanol under fuel lean conditions. Effluent post-combustion gas analysis showed that varying the equivalence ratio results in three possible modes of operation. A regime of high carbon selectivity for CO(2) occurs at low equivalence ratios and corresponds to complete combustion with a typical temperature of 775 K that is ideal for PbTe thermoelectric energy conversion devices. Conversely for equivalence ratios greater than 1, carbon selectivity for CO(2) decreases as hydrogen, olefin and paraffin production increases. By tuning the equivalence ratio, we have shown that a single device can combust completely for thermoelectric applications, operate as a fuel reformer to produce hydrogen gas for fuel cells or perform as a bio-refinery for paraffin and olefin synthesis. Published by Elsevier B.V.
C1 [Behrens, Douglas A.; Lee, Ivan C.; Waits, C. Michael] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
RP Lee, IC (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Road, Adelphi, MD 20783 USA.
EM ilee@arl.army.mil
RI Lee, Ivan/H-6444-2011
NR 18
TC 9
Z9 9
U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD APR 2
PY 2010
VL 195
IS 7
SI SI
BP 2008
EP 2013
DI 10.1016/j.jpowsour.2009.10.001
PG 6
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 547JM
UT WOS:000273883400037
ER
PT J
AU Hekman, DR
Aquino, K
Owens, BP
Mitchell, TR
Schilpzand, P
Leavitt, K
AF Hekman, David R.
Aquino, Karl
Owens, Bradley P.
Mitchell, Terence R.
Schilpzand, Pauline
Leavitt, Keith
TI AN EXAMINATION OF WHETHER AND HOW RACIAL AND GENDER BIASES INFLUENCE
CUSTOMER SATISFACTION
SO ACADEMY OF MANAGEMENT JOURNAL
LA English
DT Article
ID IMPLICIT ASSOCIATION TEST; PATIENT-PHYSICIAN RELATIONSHIP; PERFORMANCE
RATINGS; FINANCIAL PERFORMANCE; SHAREHOLDER VALUE; LABOR-MARKET; RACE;
ATTITUDES; IMPACT; DISCRIMINATION
AB We examined whether and how various biases may influence customers' satisfaction evaluations and produce discriminatory judgments for minority and female service employees. We argue that customer satisfaction evaluations are biased because they are anonymous judgments by untrained raters that usually lack an evaluation standard. Laboratory and field samples provide disturbing evidence generally confirming our arguments and suggesting that the presence of nonwhite and women service employees may produce lower aggregated customer satisfaction evaluations that may ultimately hurt individuals and organizations financially.
C1 [Hekman, David R.] Univ Wisconsin Milwaukee, Lubar Sch Business, Milwaukee, WI 53201 USA.
[Aquino, Karl] Univ British Columbia, Sauder Sch Business, Vancouver, BC V5Z 1M9, Canada.
[Owens, Bradley P.] Univ Michigan, Ctr Posit Org Scholarship, Ann Arbor, MI 48109 USA.
[Mitchell, Terence R.] Univ Washington, Seattle, WA 98195 USA.
[Schilpzand, Pauline; Leavitt, Keith] US Mil Acad, West Point, PA USA.
RP Hekman, DR (reprint author), Univ Wisconsin Milwaukee, Lubar Sch Business, Milwaukee, WI 53201 USA.
EM hekman@uwm.edu; karl.aquino@sauder.ubc.ca; bpowens@bus.umich.edu;
trm@u.washington.edu; pauline.schilpzand@usma.edu;
keith.leavitt@usma.edu
RI Leavitt, Keith/D-6686-2012
OI Leavitt, Keith/0000-0003-3729-3997
NR 107
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U1 6
U2 42
PU ACAD MANAGEMENT
PI BRIARCLIFF MANOR
PA PACE UNIV, PO BOX 3020, 235 ELM RD, BRIARCLIFF MANOR, NY 10510-8020 USA
SN 0001-4273
EI 1948-0989
J9 ACAD MANAGE J
JI Acad. Manage. J.
PD APR
PY 2010
VL 53
IS 2
BP 238
EP 264
DI 10.5465/AMJ.2010.49388763
PG 27
WC Business; Management
SC Business & Economics
GA 596BC
UT WOS:000277657300003
ER
PT J
AU Peterson, AM
Jensen, RE
Palmese, GR
AF Peterson, Amy M.
Jensen, Robert E.
Palmese, Giuseppe R.
TI Room-Temperature Healing of a Thermosetting Polymer Using the
Diels-Alder Reaction
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE biomimetic; Diels-Alder polymers; functionalization of polymers;
stimuli-sensitive polymers
ID FIBER-REINFORCED POLYMER; EPOXY-AMINE THERMOSETS; SILICA; COMPOSITES;
COPOLYMERS; MALEIMIDE; BEHAVIOR; AGENTS; RESINS
AB Self-healing materials are particularly desirable for load-bearing applications because they offer the potential For increased safety and material lifetimes. A furan-functionalized polymer network was designed that can heal via covalent bonding across the crack surface with the use of a healing agent consisting of a bismaleimide in solution. Average healing efficiencies of approximately 70% were observed. The healing ability of fiber-reinforced composite specimens was investigated with flexural, short beam shear, and double cantilever beam specimens. It was found that solvent amount and maleimide concentration play key roles in determining healing efficiency.
C1 [Peterson, Amy M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
[Jensen, Robert E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
EM palmese@coe.drexel.edu
RI Peterson, Amy/A-2945-2012
OI Peterson, Amy/0000-0002-4612-0062
FU U.S. Army Research Laboratory [W911NF-06-2-0013]; National Science
Foundation; University of Pennsylvania [DGE-0654313]; Graduate Research
Fellowship Program
FX The authors wish to acknowledge the U.S. Army Research Laboratory for
financial support under the Army Materials Center of Excellence Program,
contract W911NF-06-2-0013. Financial support for Amy M. Peterson was
provided by the National Science Foundation under the Integrated
Graduate Education and Research Traineeship in Nanoscale Science and
Engineering administered by Drexel University and the University of
Pennsylvania, Contract DGE-0654313. as well as the Graduate Research
Fellowship Program. The authors also thank Claude Robotham and Joseph
Dorsheimer of Thermo Fisher Scientific for DCB specimen surface
analysis.
NR 37
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U1 7
U2 98
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD APR
PY 2010
VL 2
IS 4
BP 1141
EP 1149
DI 10.1021/am9009378
PG 9
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA 588BT
UT WOS:000277042000031
PM 20423133
ER
PT J
AU Gerard, BF
AF Gerard, Brian F.
TI Anisotropy and Voiding at High Strain Rates in a Mg Alloy Extrudate
SO ADVANCED MATERIALS & PROCESSES
LA English
DT Article
C1 [Gerard, Brian F.] Lehigh Univ, Bethlehem, PA 18015 USA.
RP Gerard, BF (reprint author), USA, Picatinny Arsenal, NJ USA.
EM brian.f.gerard@us.army.mil
NR 0
TC 3
Z9 3
U1 0
U2 1
PU ASM INT
PI MATERIALS PARK
PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002
USA
SN 0882-7958
J9 ADV MATER PROCESS
JI Adv. Mater. Process.
PD APR
PY 2010
VL 168
IS 4
BP 32
EP 33
PG 2
WC Materials Science, Multidisciplinary
SC Materials Science
GA 582XH
UT WOS:000276633300006
ER
PT J
AU Nie, JH
Hopkins, DA
Chen, YT
Hsieh, HT
AF Nie, J. H.
Hopkins, D. A.
Chen, Y. T.
Hsieh, H. T.
TI Development of an object-oriented finite element program with adaptive
mesh refinement for multi-physics applications
SO ADVANCES IN ENGINEERING SOFTWARE
LA English
DT Article
DE Computer engineering application; Numerical modeling; Software
development
ID PARTIAL-DIFFERENTIAL EQUATIONS; ERROR ESTIMATION; COMPUTATIONS
AB In this paper, an object-oriented framework for numerical analysis of multi-physics applications is presented. The framework is divided into several basic sets of classes that enable the code segments to be built according to the type of problem to be solved. Fortran 2003 was used in the development of this finite element program due to its advantages for scientific and engineering programming and its new object-oriented features. The program was developed with h-type adaptive mesh refinement, and it was tested for several classical cases involving heat transfer, fluid mechanics and structural mechanics. The test cases show that the adaptive mesh is refined only in the localization region where the feature gradient is relatively high. The overall mesh refinement and the h-adaptive mesh refinement were justified with respect to the computational accuracy and the CPU time cost. Both methods can improve the computational accuracy with the refinement of mesh. The overall mesh refinement causes the CPU time cost to greatly increase as the mesh is refined. However, the CPU time cost does not increase very much with the increase of the level of h-adaptive mesh refinement. The CPU time cost can be saved by up to 90%, especially for the simulated system with a large number of elements and nodes. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Nie, J. H.; Chen, Y. T.; Hsieh, H. T.] Univ Nevada, Dept Mech Engn, Las Vegas, NV 89154 USA.
[Hopkins, D. A.] USA, Res Lab, Weapon & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Nie, JH (reprint author), Univ Nevada, Dept Mech Engn, Las Vegas, NV 89154 USA.
EM jianhu@nscee.edu
FU US Department of Defense (Army Research Office) [DAAD 19-03-2-0007]
FX The authors gratefully acknowledge the financial support by the US
Department of Defense (Army Research Office) under Grant No. DAAD
19-03-2-0007.
NR 49
TC 5
Z9 5
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-9978
J9 ADV ENG SOFTW
JI Adv. Eng. Softw.
PD APR
PY 2010
VL 41
IS 4
BP 569
EP 579
DI 10.1016/j.advengsoft.2009.11.004
PG 11
WC Computer Science, Interdisciplinary Applications; Computer Science,
Software Engineering; Engineering, Multidisciplinary
SC Computer Science; Engineering
GA 571ON
UT WOS:000275763700007
ER
PT J
AU Muramatsu, RS
Litzinger, MHJ
Fisher, E
Takeshita, J
AF Muramatsu, Russ S.
Litzinger, Mark H. J.
Fisher, Ed
Takeshita, Junji
TI Alternative Formulations, Delivery Methods, and Administration Options
for Psychotropic Medications in Elderly Patients With Behavioral and
Psychological Symptoms of Dementia
SO AMERICAN JOURNAL OF GERIATRIC PHARMACOTHERAPY
LA English
DT Review
DE BPSD; medication delivery; alternative medication formulations;
psychotropic medicine use in elderly
ID ENTERAL FEEDING TUBES; ATYPICAL ANTIPSYCHOTIC MEDICATIONS; NURSING-HOME
PLACEMENT; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS; PSYCHIATRIC
MEDICATIONS; INTRAVENOUS VALPROATE; COVERT MEDICATION; LATE PARAPHRENIA;
DRUG-THERAPY
AB Objective: The purpose of this paper was to review alternative formulations, delivery methods, and administration options for psychotropic medications in elderly patients with behavioral and psychological symptoms of dementia (BPSD).
Methods: A MEDLINE search was conducted initially in December 2008 and was updated in September 2009, including the search terms pharmacologic treatment and dementia, behavioral and psychological symptoms of dementia, alternative psychotropic medication formulations, alternative dosing methods of medication, drug delivery options, antidepressants and dementia, anxiolytics and dementia, antipsychotics and dementia, mood stabilizers and dementia, cognitive enhancers and dementia, medications and enteral feeding tubes, and hiding medication. Studies were limited to English-language articles dated from 1950 to 2009. Additional relevant articles were obtained by reviewing the references in the initial articles. Drug Facts and Comparisons 4.0 Online, Lexi-Comp Online, and Lexi-Drugs Online were used to obtain additional information. Targeted patients were elderly individuals with BPSD who were considered difficult to treat because they were unable to swallow, were refusing medications, or were not able to eat or drink per physician order.
Results: In addition to the standard capsule or tablet given orally, a variety of formulations and delivery methods for psychotropic medications are available. Options include short- and long-acting intramuscular, intravenous, liquid, orally disintegrating, transdermal patch, sublingual, and rectal forms. Additionally, all formulations can be further altered in substance, delivery, or both. For example, tablets may be crushed and capsules opened; this changes their formulation and allows the option of mixing with food or liquids to be taken by mouth or through a tube. Caution must be used, however; in certain cases, alteration of the original form or the intended delivery method is contraindicated. In addition, many alternative administration options are not formally approved for use in the manner in which they are commonly applied and are therefore used with little or no information on tolerability and effectiveness. Ethical and legal issues include patient consent and off-label use.
Conclusions: Overall, few studies have examined the use and efficacy of alternative psychotropic formulations and delivery methods in elderly patients with BPSD, and none have specifically addressed drug-alteration and alternative-administration issues. There is no evidence to compare alternative delivery forms (eg, tablet or capsule) of a given medication in terms of efficacy or tolerability. Still, alternative methods may be the only option for treatment of some patients. Practitioners must be familiar with the range of formulations and delivery options available so that they can optimize their patients' medication regimens. More data are needed on the use of alternative formulations, delivery methods, and administration options and their limitations in this population. (Am J Geriatr Pharmacother. 2010;8:98-114) (C) 2010 Excerpta Medica Inc.
C1 [Muramatsu, Russ S.] Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA.
[Litzinger, Mark H. J.] Philadelphia Coll Osteopath Med Georgia, Sch Pharm, Suwanee, GA USA.
[Fisher, Ed] Univ Hawaii, Coll Pharm, Hilo, HI 96720 USA.
[Takeshita, Junji] Univ Hawaii, John A Burns Sch Med, Dept Psychiat, Honolulu, HI 96822 USA.
RP Muramatsu, RS (reprint author), Tripler Army Med Ctr, Dept Psychiat, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM russ.muramatsu@amedd.army.mil
FU Department of Psychiatry, Tripler Army Medical Center (TAMC), Honolulu,
Hawaii
FX This study was funded by the Department of Psychiatry, Tripler Army
Medical Center (TAMC), Honolulu, Hawaii. The views expressed in this
manuscript are those of the authors and do not reflect the official
policy or position of the TAMC Department of Psychiatry, Department of
the Army, Department of Defense, or the US Government. The authors have
indicated that they have no other conflicts of interest regarding the
content of this article.
NR 85
TC 9
Z9 9
U1 3
U2 24
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 1543-5946
J9 AM J GERIATR PHARMAC
JI Am. J. Geriatr. Pharmacother.
PD APR
PY 2010
VL 8
IS 2
BP 98
EP 114
DI 10.1016/j.amjopharm.2010.03.003
PG 17
WC Geriatrics & Gerontology; Pharmacology & Pharmacy
SC Geriatrics & Gerontology; Pharmacology & Pharmacy
GA 589NQ
UT WOS:000277157400001
PM 20439060
ER
PT J
AU Kraft, M
Amick, MM
Barth, JT
French, LM
Lew, HL
AF Kraft, Malissa
Amick, Melissa M.
Barth, Jeffrey T.
French, Louis M.
Lew, Henry L.
TI A Review of Driving Simulator Parameters Relevant to the Operation
Enduring Freedom/Operation Iraqi Freedom Veteran Population
SO AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
LA English
DT Review
DE Brain Injury; Driving; Virtual Reality; Posttraumatic Stress Disorder
ID TRAUMATIC BRAIN-INJURY; OBSTRUCTIVE SLEEP-APNEA;
POSTTRAUMATIC-STRESS-DISORDER; ALZHEIMER-DISEASE; WAKEFULNESS TEST;
MEDICAL FITNESS; PERSIAN-GULF; PERFORMANCE; ALCOHOL; US
AB Kraft M, Amick MM, Barth JT, French LM, Lew HL: A review of driving simulator parameters relevant to the Operation Enduring Freedom/Operation Iraqi Freedom veteran population. Am J Phys Med Rehabil 2010;89:336-344.
There is currently a pressing need for safe, reliable, cost-effective methods of evaluating driving ability. With recent improvements in virtual reality technology, driving simulators seem to offer a promising alternative to on-road methods of driving assessment. One population at risk for driving difficulties may be veterans returning from combat in Iraq or Afghanistan. The use of driving simulators to evaluate and remediate veterans' abilities to operate a motor vehicle is a rehabilitative goal. However, there are no consistent standardized procedures for determining safe from unsafe driving using driving simulators, which limit the clinical utility of this important tool. The purposes of this article are (1) to give the reader a better understanding of the parameters that are most commonly measured in the driving simulation literature and (2) to review parameters that are most relevant for the Operation Enduring Freedom/Operation Iraqi Freedom veteran population.
C1 [Lew, Henry L.] VA Boston Hlth Care Syst, PM&R Serv, Dept Vet Affairs, Boston, MA 02130 USA.
[Kraft, Malissa; Amick, Melissa M.; Lew, Henry L.] VA Boston Healthcare Syst, Polytrauma & Traumat Brain Injury Ctr, Boston, MA USA.
[Lew, Henry L.] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA.
[Barth, Jeffrey T.; Lew, Henry L.] Virginia Neurocare, Def & Vet Brain Injury Ctr, Charlottesville, VA USA.
[Barth, Jeffrey T.] Lakeview Healthcare Syst, Charlottesville, VA USA.
[Barth, Jeffrey T.] Univ Virginia, Sch Med, Div Neuropsychol, Charlottesville, VA 22908 USA.
[French, Louis M.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA.
[French, Louis M.] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA.
[French, Louis M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA.
RP Lew, HL (reprint author), VA Boston Hlth Care Syst, PM&R Serv, Dept Vet Affairs, 150 S Huntington Ave, Boston, MA 02130 USA.
NR 69
TC 12
Z9 12
U1 2
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0894-9115
J9 AM J PHYS MED REHAB
JI Am. J. Phys. Med. Rehabil.
PD APR
PY 2010
VL 89
IS 4
BP 336
EP 344
DI 10.1097/PHM.0b013e3181d3eb5f
PG 9
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA 584CA
UT WOS:000276726400009
PM 20299851
ER
PT J
AU Forman, HP
Javitt, MC
Monsees, B
Crowe, JK
Beauchamp, NJ
Larson, DB
Kaye, A
Kazerooni, EA
Norbash, A
Messinger, N
Hricak, H
Thrall, JH
AF Forman, Howard P.
Javitt, Marcia C.
Monsees, Barbara
Crowe, John K.
Beauchamp, Norman J., Jr.
Larson, David B.
Kaye, Alan
Kazerooni, Ella A.
Norbash, Alexander
Messinger, Neil
Hricak, Hedvig
Thrall, James H.
TI Masters of Radiology Panel Discussion: Role of Communication in Today's
Radiologic Practices
SO AMERICAN JOURNAL OF ROENTGENOLOGY
LA English
DT Editorial Material
DE communications; critical reports; MQSA; technology
C1 [Forman, Howard P.] Yale Univ, MBA Program, New Haven, CT 06520 USA.
[Forman, Howard P.] Yale Univ, MBA Execut, New Haven, CT USA.
[Javitt, Marcia C.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA.
[Monsees, Barbara] Washington Univ, Med Ctr, Mallinckrodt Inst Radiol, Breast Imaging Sect, St Louis, MO 63110 USA.
[Crowe, John K.] Scottsdale Med Imaging, Scottsdale, AZ USA.
[Beauchamp, Norman J., Jr.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA.
[Larson, David B.] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH USA.
[Kaye, Alan] Bridgeport Hosp, Dept Radiol, Westport, CT USA.
[Kazerooni, Ella A.] Univ Michigan Hosp, Dept Radiol, Ann Arbor, MI 48109 USA.
[Norbash, Alexander] Boston Univ, Med Ctr, Dept Radiol, Boston, MA 02118 USA.
[Messinger, Neil] Baptist Hlth Syst, Dept Radiol, Miami, FL USA.
[Hricak, Hedvig] Mem Sloan Kettering Canc Ctr, Dept Radiol, Seattle, WA USA.
[Thrall, James H.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA.
RP Forman, HP (reprint author), Yale Univ, MBA Program, New Haven, CT 06520 USA.
EM howard.forman@yale.edu
OI Norbash, Alexander/0000-0003-2986-2563; Hricak,
Hedvig/0000-0003-2240-9694
NR 0
TC 3
Z9 3
U1 0
U2 0
PU AMER ROENTGEN RAY SOC
PI RESTON
PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA
SN 0361-803X
J9 AM J ROENTGENOL
JI Am. J. Roentgenol.
PD APR
PY 2010
VL 194
IS 4
BP 1014
EP 1017
DI 10.2214/AJR.09.4060
PG 4
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 572VX
UT WOS:000275863300023
PM 20308504
ER
PT J
AU Waterman, BR
Belmont, PJ
Cameron, KL
DeBerardino, TM
Owens, BD
AF Waterman, Brian R.
Belmont, Philip J., Jr.
Cameron, Kenneth L.
DeBerardino, Thomas M.
Owens, Brett D.
TI Epidemiology of Ankle Sprain at the United States Military Academy
SO AMERICAN JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE ankle; sprain; epidemiology; risk factor; military
ID CRUCIATE LIGAMENT INJURY; EXERCISE-RELATED INJURIES; INTRINSIC
RISK-FACTORS; FEMALE ARMY TRAINEES; HIGH-SCHOOL SPORTS; LATERAL ANKLE;
SYNDESMOSIS SPRAINS; ATHLETIC POPULATION; BASKETBALL PLAYERS; SOCCER
INJURIES
AB Background: Ankle sprain is a common injury in athletic populations that results in significant time lost to injury.
Hypothesis: The incidence rates (IRs) of ankle ligament sprains are influenced by gender, height, weight, body mass index (BMI), physical conditioning, level of competition, type of sport, and athlete exposure to sport.
Study Design: Cohort study; Level of evidence, 2.
Methods: A longitudinal cohort study was performed to determine the effect of risk factors for ankle sprain at the United States Military Academy between 2005 and 2007.
Results: A total 614 cadets sustained new ankle sprains during 10511 person-years at risk, resulting in an overall IR of 58.4 per 1000 person-years. Women (96.4), compared with men (52.7), had a significantly increased rate ratio (IRR) for ankle sprain of 1.83 (95% confidence interval [CI], 1.52-2.20). Men with ankle sprains had higher mean height, weight, and BMI than uninjured men (P < .001). Men with ankle sprains had higher average scores in push-ups, sit-ups, and run time than uninjured men (P < .001). Ankle sprain occurred most commonly during athletics (64.1%). Ankle sprain IR did not significantly differ between intercollegiate and intramural athletic competition after controlling for athlete-exposure (IRR, 1.05; 95% CI, 0.81-1.37). The ankle sprain IRR of female compared with male intercollegiate athletes was 0.93 (95% CI, 0.67-1.32) per 1000 person-years and 1.04 (95% CI, 0.74-1.47) per 1000 athlete-exposures. The intercollegiate sports of men's rugby, women's cheerleading, and men's/women's basketball, soccer, and lacrosse had the highest ankle sprain IR.
Conclusion: Higher mean height and weight in men, increased BMI in men, greater physical conditioning in men, and athlete exposure to selected sports were all risk factors for ankle sprain.
C1 [Owens, Brett D.] US Mil Acad, Orthopaed Surg Serv, Keller Army Hosp, West Point, NY 10996 USA.
[Waterman, Brian R.; Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA.
[DeBerardino, Thomas M.] Univ Connecticut, Ctr Hlth, Farmington, CT USA.
RP Waterman, BR (reprint author), US Mil Acad, Orthopaed Surg Serv, Keller Army Hosp, West Point, NY 10996 USA.
EM b.owens@us.army.mil
OI DeBerardino, Thomas/0000-0002-7110-8743; Belmont,
Philip/0000-0003-2618-199X; Cameron, Kenneth/0000-0002-6276-4482
NR 62
TC 50
Z9 52
U1 5
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0363-5465
J9 AM J SPORT MED
JI Am. J. Sports Med.
PD APR
PY 2010
VL 38
IS 4
BP 979
EP 803
DI 10.1177/0363546509350757
PG 7
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA 576RZ
UT WOS:000276167200019
PM 20145281
ER
PT J
AU Lee, JJ
Hurst, FP
Abbott, KC
Agodoa, LY
Jindal, RM
AF Lee, Jessica J.
Hurst, Frank P.
Abbott, Kevin C.
Agodoa, Lawrence Y.
Jindal, Rahul M.
TI Outcomes Associated with Influenza Vaccination in the First Year after
Kidney Transplantation: Analysis of USRDS
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Meeting Abstract
CT 10th American Transplant Congress
CY MAY 01-05, 2010
CL San Diego, CA
SP Amer Soc Transplantat
C1 [Lee, Jessica J.; Hurst, Frank P.; Abbott, Kevin C.; Jindal, Rahul M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Agodoa, Lawrence Y.] NIDDK, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1600-6135
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD APR
PY 2010
VL 10
SU 4
SI SI
BP 127
EP 127
PG 1
WC Surgery; Transplantation
SC Surgery; Transplantation
GA 573NX
UT WOS:000275921701292
ER
PT J
AU Hurst, FP
Sajjad, I
Elster, EA
Falta, EM
Agodoa, LY
Abbott, KC
Jindal, RM
AF Hurst, Frank P.
Sajjad, Imran
Elster, Eric A.
Falta, Edward M.
Agodoa, Lawrence Y.
Abbott, Kevin C.
Jindal, Rahul M.
TI Transplantation of A2 Kidneys into B and O Recipients: USRDS Experience.
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Meeting Abstract
CT 10th American Transplant Congress
CY MAY 01-05, 2010
CL San Diego, CA
SP Amer Soc Transplantat
C1 [Hurst, Frank P.; Elster, Eric A.; Falta, Edward M.; Abbott, Kevin C.; Jindal, Rahul M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Sajjad, Imran] Univ Wisconsin, Madison, WI USA.
[Agodoa, Lawrence Y.] NIDDK, Natl Inst Hlth, Bethesda, MD USA.
[Jindal, Rahul M.] George Washington Univ, Med Ctr, Washington, DC 20037 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1600-6135
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD APR
PY 2010
VL 10
SU 4
SI SI
BP 282
EP 282
PG 1
WC Surgery; Transplantation
SC Surgery; Transplantation
GA 573NX
UT WOS:000275921702254
ER
PT J
AU Stevens, K
Phinney, S
Graybill, C
Gillern, S
Salifu, MO
Jindal, RM
Brown, TS
Elster, EA
AF Stevens, Kristin
Phinney, Samuel
Graybill, Christopher
Gillern, Suzanne
Salifu, Moro O.
Jindal, Rahul M.
Brown, Trevor S.
Elster, Eric A.
TI Bayesian Modeling of the United States Renal Data System Pre-Transplant
Variables Accurately Predicts Graft Survival
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Meeting Abstract
CT 10th American Transplant Congress
CY MAY 01-05, 2010
CL San Diego, CA
SP Amer Soc Transplantat
C1 [Stevens, Kristin; Phinney, Samuel; Graybill, Christopher; Gillern, Suzanne; Brown, Trevor S.; Elster, Eric A.] USN, Med Res Ctr, Silver Spring, MD USA.
[Salifu, Moro O.] Suny Downstate Med Ctr, Transplant Program, Brooklyn, NY 11203 USA.
[Phinney, Samuel; Graybill, Christopher; Gillern, Suzanne; Jindal, Rahul M.] Walter Reed Army Med Ctr, Transplant Program, Washington, DC 20307 USA.
[Stevens, Kristin] USN, San Diego Med Ctr, Dept Surg, San Diego, CA 92152 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1600-6135
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD APR
PY 2010
VL 10
SU 4
SI SI
BP 369
EP 369
PG 1
WC Surgery; Transplantation
SC Surgery; Transplantation
GA 573NX
UT WOS:000275921702567
ER
PT J
AU Nam, DH
Oh, JS
Nam, MH
Park, HC
Lim, CS
Lee, WJ
Sattabongkot, J
Klein, TA
Ayala, FJ
AF Nam, Deok Hwa
Oh, Jun Seo
Nam, Myoung Hyun
Park, Hae Chul
Lim, Chae Seung
Lee, Won Ja
Sattabongkot, Jetsumon
Klein, Terry A.
Ayala, Francisco J.
TI Short Report: Emergence of New Alleles of the MSP-3 alpha Gene in
Plasmodium vivax Isolates from Korea
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID MEROZOITE SURFACE PROTEIN-3-ALPHA; DIVERSITY; MALARIA; POLYMORPHISM;
INFECTIONS
AB Nucleotide sequence analysis of the Plasmodium vivax PvMSP-3 alpha gene was conducted on blood from 143 malaria patients admitted to Korea University Medical Center from 1996 to 2007 in the Republic of Korea (ROK). From 1996 to 2002, the PvMSP-3 alpha alleles were of two types, SKOR-67 (2.53 kb) and SKOR-69 (1.78 kb), which differed in length and amino acid sequence. Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006-2007 accounted for nearly 50% (25/51) of the sampled isolates. The new variants had the same amino acid sequence as SKOR-69 in the N-terminal region, but in Blocks I and II and in the C-terminal region, they were similar to previously reported isolates from Thailand, Papua New Guinea, India, Brazil, and Ecuador strains.
C1 [Nam, Deok Hwa; Nam, Myoung Hyun; Lim, Chae Seung] Korea Univ, Coll Med, Brain Korea Grad Sch Med 21, Dept Lab Med, Seoul 136705, South Korea.
[Oh, Jun Seo] Korea Univ, Coll Med, Brain Korea Grad Sch Med 21, Cellular Oncol Lab, Seoul 136705, South Korea.
[Lee, Won Ja] Minist Hlth & Welf, Korean Ctr Dis Control & Prevent, Lab Med Entomol, Seoul, South Korea.
[Sattabongkot, Jetsumon] US Army Mil Component, Armed Forces Inst Med Sci, Dept Entomol, Bangkok, Thailand.
[Klein, Terry A.] 65th Med Brigade, Force Hlth Protect, Unit 15281, Seoul, South Korea.
[Ayala, Francisco J.] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92717 USA.
[Park, Hae Chul] Korea Univ, Coll Med, Brain Korea Grad Sch Med 21, Lab Neurodev, Seoul 136705, South Korea.
RP Lim, CS (reprint author), Korea Univ, Ansan Hosp, Coll Med, Dept Lab Med, 516 Gojan Dong, Ansan 425707, Gyoenggi Prov, South Korea.
EM malarim@korea.ac.kr
RI Valle, Ruben/A-7512-2013
NR 9
TC 5
Z9 6
U1 0
U2 0
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD APR
PY 2010
VL 82
IS 4
BP 522
EP 524
DI 10.4269/ajtmh.2010.08-0332
PG 3
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 577JR
UT WOS:000276219700003
PM 20348492
ER
PT J
AU Kolodzinski, JJ
Tannenbaum, LV
Muller, LI
Osborn, DA
Adams, KA
Conner, MC
Ford, WM
Miller, KV
AF Kolodzinski, Jeffrey J.
Tannenbaum, Lawrence V.
Muller, Lisa I.
Osborn, David A.
Adams, Kent A.
Conner, Mark C.
Ford, W. Mark
Miller, Karl V.
TI Excursive Behaviors by Female White-tailed Deer during Estrus at Two
Mid-Atlantic Sites
SO AMERICAN MIDLAND NATURALIST
LA English
DT Article
AB Current research suggests that female white-tailed deer (Odocoileus virginianus) will adopt sedentary breeding strategies in populations with an abundance of males and a more active mate-searching strategy in low-density or unbalanced herds. We used GPS collars to document, the movements of 10 female deer during the breeding season at two Mid-Atlantic study sites that support high-density herds with nearly equal sex ratios. We calculated 95% and 50% seasonal and weekly kernel home ranges and the daily percentage of points located outside of the seasonal home range (SHR). Peaks in weekly home range size and in the percentage of points located outside of the SHR occurred between 7 Nov. and 9 Dec. ((x) over bar = 22 Nov.) for eight deer. Past data from one of the study sites have indicated that most breeding activity occurs from 5-25 Nov. Peaks in the percentage of points outside of the SHR corresponded to brief ((x) over bar = 24.0 h, SD = 18.2 h; range 8-68 h) excursions. On peak days, 46-100% ((x) over bar = 68.3%, SD = 17.1%) of data points were located outside of the SHR. No other excursions were observed during the 17 wk study period. Our results suggest that female deer may travel outside of their home range during the breeding season even when presented with an abundance of potential mates; these data suggest females are engaging in a discrete form of mate selection.
C1 [Kolodzinski, Jeffrey J.; Osborn, David A.; Miller, Karl V.] Univ Georgia, DB Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA.
[Ford, W. Mark] USA, Ecol Resources Branch, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Conner, Mark C.] DuPont Agr Enterprise, Chesapeake Farms, Chestertown, MD 21620 USA.
[Adams, Kent A.] Natl Wild Turkey Federat, Effingham, IL 62401 USA.
[Muller, Lisa I.] Univ Tennessee, Dept Forestry Wildlife & Fisheries, Knoxville, TN 37996 USA.
[Tannenbaum, Lawrence V.] USA, Ctr Hlth Promot & Prevent Med, MCHB TS REH, Aberdeen Proving Ground, MD 21010 USA.
RP Miller, KV (reprint author), Univ Georgia, DB Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA.
EM kmiller@warnell.uga.edu
OI Muller, Lisa/0000-0001-7833-2273
FU Department of Defense; U.S. Army Environmental Command; U.S. Forest
Service; Northern Research Station; University of Tennessee
FX We thank the Department of Defense, U.S. Army Environmental Command, the
U.S. Forest Service, Northern Research Station and the University of
Tennessee for funding this research. Chesapeake Farms and Delaware Wild
Lands Inc. graciously allowed us to conduct this study on their
properties and provided welcomed logistical support. We thank Ralph
Fleege, Ron Haas, Vanessa Lane and Family, Dustin Rutledge, Jenny
Petersen, and Blake Fountain for field assistance and Michael T. Sense
and the Delaware Department of Agriculture for the use of a dart rifle.
NR 17
TC 10
Z9 11
U1 2
U2 13
PU AMER MIDLAND NATURALIST
PI NOTRE DAME
PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA
SN 0003-0031
EI 1938-4238
J9 AM MIDL NAT
JI Am. Midl. Nat.
PD APR
PY 2010
VL 163
IS 2
BP 366
EP 373
DI 10.1674/0003-0031-163.2.366
PG 8
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 575ET
UT WOS:000276050400010
ER
PT J
AU Darling, MJ
Bryant, SD
Kunz, AN
Weisse, ME
AF Darling, Matthew J.
Bryant, Summer D.
Kunz, Anjali N.
Weisse, Martin E.
TI Necrobacillosis: A case report of complicated Fusobacterium necrophorum
septicemia
SO ANAEROBE
LA English
DT Article
DE Necrobacillosis; Lemierre's syndrome; Fusobacterium necrophorum
ID LEMIERRES-SYNDROME; THROMBOPHLEBITIS; PHARYNGITIS; INFECTION; CHILDREN
AB Necrobacillosis due to Fusobacterium necrophorum is an uncommon anaerobic infection. It has a wide range of presentations and commonly presents as Lemierre's syndrome. We present a case of necrobacillosis defined by F. necrophorum bacteremia with epidural and pararectal fluid collection without evidence of internal jugular vein thrombophlebitis. Published by Elsevier Ltd.
C1 [Darling, Matthew J.; Bryant, Summer D.; Kunz, Anjali N.; Weisse, Martin E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Darling, MJ (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM matt.darling@nccpeds.com
NR 14
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1075-9964
J9 ANAEROBE
JI Anaerobe
PD APR
PY 2010
VL 16
IS 2
BP 171
EP 173
DI 10.1016/j.anaerobe.2009.05.005
PG 3
WC Microbiology
SC Microbiology
GA 597CW
UT WOS:000277734600017
PM 19501182
ER
PT J
AU Maier, RM
Palmer, MW
Andersen, GL
Halonen, MJ
Josephson, KC
Maier, RS
Martinez, FD
Neilson, JW
Stern, DA
Vercelli, D
Wright, AL
AF Maier, Raina M.
Palmer, Michael W.
Andersen, Gary L.
Halonen, Marilyn J.
Josephson, Karen C.
Maier, Robert S.
Martinez, Fernando D.
Neilson, Julia W.
Stern, Debra A.
Vercelli, Donata
Wright, Anne L.
TI Environmental Determinants of and Impact on Childhood Asthma by the
Bacterial Community in Household Dust
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID GRADIENT GEL-ELECTROPHORESIS; CANONICAL CORRESPONDENCE-ANALYSIS; 16S
RIBOSOMAL-RNA; EARLY-LIFE; YOUNG-CHILDREN; EXPOSURE; RISK; POPULATIONS;
ENDOTOXIN; AGE
AB Asthma increased dramatically in the last decades of the 20th century and is representative of chronic diseases that have been linked to altered microbial exposure and immune responses. Here we evaluate the effects of environmental exposures typically associated with asthma protection or risk on the microbial community structure of household dust ( dogs, cats, and day care). PCR-denaturing gradient gel analysis (PCR-DGGE) demonstrated that the bacterial community structure in house dust is significantly impacted by the presence of dogs or cats in the home (P = 0.0190 and 0.0029, respectively) and by whether or not children attend day care (P = 0.0037). In addition, significant differences in the dust bacterial community were associated with asthma outcomes in young children, including wheezing (P = 0.0103) and specific IgE (P = 0.0184). Our findings suggest that specific bacterial populations within the community are associated with either risk or protection from asthma.
C1 [Maier, Raina M.; Josephson, Karen C.; Neilson, Julia W.] Univ Arizona, Dept Soil Water & Environm Sci, Tucson, AZ 85721 USA.
[Vercelli, Donata] Univ Arizona, Dept Cell Biol & Anat, Tucson, AZ 85721 USA.
[Martinez, Fernando D.; Wright, Anne L.] Univ Arizona, Dept Pediat, Tucson, AZ 85721 USA.
[Halonen, Marilyn J.] Univ Arizona, Dept Pharmacol, Tucson, AZ 85721 USA.
[Halonen, Marilyn J.; Martinez, Fernando D.; Stern, Debra A.; Vercelli, Donata; Wright, Anne L.] Univ Arizona, Arizona Resp Ctr, Tucson, AZ 85721 USA.
[Palmer, Michael W.] Oklahoma State Univ, Dept Bot, Stillwater, OK 74078 USA.
[Andersen, Gary L.] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Earth Sci, Berkeley, CA 94720 USA.
[Maier, Robert S.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Maier, RM (reprint author), Univ Arizona, Dept Soil Water & Environm Sci, 429 Shantz Bldg 38, Tucson, AZ 85721 USA.
EM rmaier@ag.arizona.edu
RI Palmer, Michael/A-2519-2008; Andersen, Gary/G-2792-2015
OI Andersen, Gary/0000-0002-1618-9827
FU NIAID NIH HHS [AI61811, R01 AI042268, AI 42268, R01 AI061811]
NR 29
TC 30
Z9 31
U1 0
U2 10
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD APR
PY 2010
VL 76
IS 8
BP 2663
EP 2667
DI 10.1128/AEM.01665-09
PG 5
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 578FX
UT WOS:000276280100036
PM 20154107
ER
PT J
AU Nersisyan, SR
Tabiryan, NV
Steeves, DM
Kimball, BR
Chigrinov, VG
Kwok, HS
AF Nersisyan, Sarik R.
Tabiryan, Nelson V.
Steeves, Diane M.
Kimball, Brian R.
Chigrinov, Vladimir G.
Kwok, Hoi Sing
TI Study of azo dye surface command photoalignment material for photonics
applications
SO APPLIED OPTICS
LA English
DT Article
ID POLARIZATION CONVERTERS; ALIGNING LAYERS; LIQUID-CRYSTALS; GENERATION;
LIGHT
AB We provide detailed quantitative characterization of sulfonic bisazodye SD1 as a photoalignment material for photonics applications. The reversibility of photoalignment was tested for transformations between planar and 90 degrees twist orientation states in a liquid crystal (LC) cell using polarized UV light. No degradation was observed for 100 cycles of transformations. A given twist angle of the LC orientation was obtained in a single step, as well as in a sequence of gradually increasing angles. A hysteresis is revealed in the latter case for planar-twist-planar cycles. The material was used for obtaining patterned orientation of a LC polymer providing similarly good quality photoalignment for UV as well as visible light. High efficiency large area and high spatial frequency optical axis gratings (or, polarization gratings) were demonstrated on a polycarbonate substrate. We show the opportunity of obtaining photoalignment in a multilayer system with single exposure to a polarized light. Finally, we provide evidence of a positive feedback in the dynamics of photoalignment due to the orientational effect of an increasing number of aligned molecules. (C) 2010 Optical Society of America
C1 [Steeves, Diane M.; Kimball, Brian R.] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
[Nersisyan, Sarik R.; Tabiryan, Nelson V.] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA.
[Chigrinov, Vladimir G.; Kwok, Hoi Sing] Hong Kong Univ Sci & Technol, Dept Elect & Elect Engn, Kowloon, Hong Kong, Peoples R China.
RP Kimball, BR (reprint author), USA, Natick Soldier Res, Ctr Dev & Engn, Kansas St, Natick, MA 01760 USA.
EM Brian.R.Kimball@us.army.mil
FU Hong Kong University of Science and Technology (HKUST) [CERG 612409,
CERG 612208, RPC07/08.EG01]
FX V. Chigrinov acknowledges support from Hong Kong University of Science
and Technology (HKUST) grants CERG 612409, CERG 612208, and
RPC07/08.EG01. This document has been approved for public release. U. S.
Army Natick Soldier Research, Development and Engineering Center Public
Affairs Office U09-192.
NR 31
TC 12
Z9 12
U1 5
U2 14
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD APR 1
PY 2010
VL 49
IS 10
BP 1720
EP 1727
DI 10.1364/AO.49.001720
PG 8
WC Optics
SC Optics
GA 576WD
UT WOS:000276179500045
PM 20357851
ER
PT J
AU Auger, JC
Fernandes, GE
Aptowicz, KB
Pan, YL
Chang, RK
AF Auger, J. -C.
Fernandes, G. E.
Aptowicz, K. B.
Pan, Y. -L.
Chang, R. K.
TI Influence of surface roughness on the elastic-light scattering patterns
of micron-sized aerosol particles
SO APPLIED PHYSICS B-LASERS AND OPTICS
LA English
DT Article
ID BIOLOGICAL PARTICLES; CLASSIFICATION
AB The relation between the surface roughness of aerosol particles and the appearance of island-like features in their angle-resolved elastic-light scattering patterns is investigated both experimentally and with numerical simulation. Elastic scattering patterns of polystyrene spheres, Bacillus subtilis spores and cells, and NaCl crystals are measured and statistical properties of the island-like intensity features in their patterns are presented. The island-like features for each class of particle are found to be similar; however, principal-component analysis applied to extracted features is able to differentiate between some of the particle classes. Numerically calculated scattering patterns of Chebyshev particles and aggregates of spheres are analyzed and show qualitative agreement with experimental results.
C1 [Auger, J. -C.; Fernandes, G. E.; Chang, R. K.] Yale Univ, Ctr Laser Diagnost, New Haven, CT 06520 USA.
[Auger, J. -C.; Fernandes, G. E.; Chang, R. K.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA.
[Aptowicz, K. B.] W Chester Univ, Dept Phys, W Chester, PA 19383 USA.
[Pan, Y. -L.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Auger, JC (reprint author), Yale Univ, Ctr Laser Diagnost, New Haven, CT 06520 USA.
EM augerjc@gmail.com
FU Defense Threat Reduction Agency
FX This research was supported by the Defense Threat Reduction Agency under
the Physical Science and Technology Basic Research Program.
NR 18
TC 7
Z9 7
U1 2
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0946-2171
J9 APPL PHYS B-LASERS O
JI Appl. Phys. B-Lasers Opt.
PD APR
PY 2010
VL 99
IS 1-2
BP 229
EP 234
DI 10.1007/s00340-010-3914-0
PG 6
WC Optics; Physics, Applied
SC Optics; Physics
GA 573EW
UT WOS:000275892200035
ER
PT J
AU Johnson, MS
McFarland, CA
Bazar, MA
Quinn, MJ
LaFiandra, EM
Talent, LG
AF Johnson, Mark S.
McFarland, Craig A.
Bazar, Matthew A.
Quinn, Michael J., Jr.
LaFiandra, Emily May
Talent, Larry G.
TI Toxicity of Octahydro-1,3,5,7-Tetranitro-1,3,5,7-Tetrazocine (HMX) in
Three Vertebrate Species
SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
ID EXPOSURE; 2,4,6-TRINITROTOLUENE; STAGEWISE; FATE
AB The explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine or high-melting explosive (HMX), has been found in soils in areas used for testing and training by the military. Many of these areas contain habitat for valued wildlife species. In an effort to better understand the environmental consequences from exposure, a reptilian (western fence lizard [Sceloporus occidentalis]), an amphibian (red-backed salamander [Plethodon cinereus]), and a mammalian species (rabbit [Oryctolagus cuniculus]) were exposed to HMX under controlled laboratory conditions. Lizards and rabbits were exposed to HMX by way of corn oil through gavage, and salamanders were exposed to HMX in soil. Two deaths occurred from acute oral exposures to lizards to 5000 mg HMX/kg BW. Histological and gross pathologic assessment suggested gut impaction as a possible cause of death. Salamanders exposed to concentrations of HMX in soil a parts per thousand currency sign1970 mg HMX/kg soil for 10 days did not show adverse effects. Rabbits, however, showed neurologic effects manifested as hyperkinetic events with convulsions at > 24 h after oral exposures. An LD(50) for rabbits was calculated as 93 mg/kg (95% confidence interval 76-117). A subacute 14-day testing regime found a lowest observed effect level of 10 mg/kg-d and a no observed adverse effect level of 5 mg/kg-d based on hyperkinesia and seizure incidence, although changes suggesting functional hepatic alterations were also found. These data suggest that physiologic differences between species, particularly in gastrointestinal structure and function, can affect the absorption of HMX and hence lead to marked differences in toxicity from exposure to the same compound.
C1 [Johnson, Mark S.; McFarland, Craig A.; Bazar, Matthew A.; Quinn, Michael J., Jr.; LaFiandra, Emily May] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA.
[Talent, Larry G.] Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74078 USA.
RP Johnson, MS (reprint author), USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA.
EM mark.s.johnson@us.army.mil
FU Strategic Environmental Research and Development (SERDP) program
[ER1420]
FX We thank Curtis Oliver and Michael Hable for analytic chemistry support,
Patricia Beall for laboratory coordination, Kristie Mozzachio and
Kyleigh Mahard for histopathology, and Ann Schiavetta for veterinary
care. This work was funded by the Strategic Environmental Research and
Development (SERDP) program through ER1420. The views expressed in this
article are those of the authors and do not necessarily reflect the
views and policies of the United States Army. Mention of trade names or
commercial products does not constitute endorsement or recommendation
for use.
NR 24
TC 4
Z9 4
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-4341
J9 ARCH ENVIRON CON TOX
JI Arch. Environ. Contam. Toxicol.
PD APR
PY 2010
VL 58
IS 3
BP 836
EP 843
DI 10.1007/s00244-009-9431-7
PG 8
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 581GV
UT WOS:000276510700037
PM 20012743
ER
PT J
AU Heller, CE
AF Heller, Charles E.
TI The US Army, the Civilian Conservation Corps, and Leadership for World
War II, 1933-1942
SO ARMED FORCES & SOCIETY
LA English
DT Article
DE Civilian Conservation Corps (CCC); Great Depression; World War II
mobilization; interwar period
AB Prior to World War II, the U.S. Army numbered 187,000 soldiers. Its growth to more than 8 million was a significant accomplishment. Little known to most, the Franklin D. Roosevelt administration's youth program, the Civilian Conservation Corps (CCC), provided the pretrained manpower to fill the U.S. Army's ranks upon mobilization with men who readily assumed the role of Non-Commissioned Officers (NCOs). It also gave Organized Reserve Corps officers the opportunity to occupy leadership positions, an experience that would have been unavailable otherwise. By the same token, it allowed the Regular Army to assess the leadership potential of both Regular and Reserve Officers in leading future citizen soldiers. Last, it provided the Army with an opportunity to exercise its mobilization plans.
C1 USA, Command & Gen Staff Coll, Dept Command & Leadership, Ft Leavenworth, KS USA.
RP Heller, CE (reprint author), USA, Command & Gen Staff Coll, Dept Command & Leadership, Ft Leavenworth, KS USA.
NR 32
TC 1
Z9 1
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0095-327X
J9 ARMED FORCES SOC
JI Armed Forces Soc.
PD APR
PY 2010
VL 36
IS 3
BP 439
EP 453
DI 10.1177/0095327X09333944
PG 15
WC Political Science; Sociology
SC Government & Law; Sociology
GA 571GF
UT WOS:000275739100003
ER
PT J
AU Mizuno, DR
Kraemer, KE
Flagey, N
Billot, N
Shenoy, S
Paladini, R
Ryan, E
Noriega-Crespo, A
Carey, SJ
AF Mizuno, D. R.
Kraemer, K. E.
Flagey, N.
Billot, N.
Shenoy, S.
Paladini, R.
Ryan, E.
Noriega-Crespo, A.
Carey, S. J.
TI A CATALOG OF MIPSGAL DISK AND RING SOURCES
SO ASTRONOMICAL JOURNAL
LA English
DT Article
DE catalogs; infrared: ISM; planetary nebulae: general
ID SPITZER-SPACE-TELESCOPE; INNER GALACTIC PLANE; IMAGING SURVEY; MU-M;
NEBULA; DISCOVERY; GLIMPSE; CANDIDATES; OBJECTS; IMAGES
AB We present a catalog of 416 extended, resolved, disk and ringlike objects as detected in theMIPSGAL 24 mu m survey of the Galactic plane. This catalog is the result of a search in the MIPSGAL image data for generally circularly symmetric, extended "bubbles" without prior knowledge or expectation of their physical nature. Most of the objects have no extended counterpart at 8 mu m or 70 mu m, with less than 20% detections at each wavelength. For the 54 objects with central point sources, the sources are nearly always seen in all Infrared Array Camera bands. About 70 objects (16%) have been previously identified, with another 35 listed as Infrared Astronomical Satellite sources. Among the identified objects, those with central sources are mostly listed as emission-line stars, but with other source types including supernova remnants (SNRs), luminous blue variables, and planetary nebulae (PNe). The 57 identified objects (of 362) without central sources are nearly all PNe (similar to 90%), which suggests that a large fraction of the 300+ unidentified objects in this category are also PNe. These identifications suggest that this is primarily a catalog of evolved stars. Also included in the catalog are two filamentary objects that are almost certainly SNRs, and 10 unusual compact extended objects discovered in the search. Two of these show remarkable spiral structure at both 8 mu m and 24 mu m. These are likely background galaxies previously hidden by the intervening Galactic plane.
C1 [Mizuno, D. R.] Boston Coll, Inst Sci Res, Chestnut Hill, MA 02467 USA.
[Kraemer, K. E.] USA, Res Lab, RVBYB, Hanscom Afb, MA 01731 USA.
[Flagey, N.; Paladini, R.; Noriega-Crespo, A.; Carey, S. J.] CALTECH, Spitzer Sci Ctr, Pasadena, CA 91125 USA.
[Billot, N.] CALTECH, Infrared Proc & Anal Ctr, Pasadena, CA 91125 USA.
[Shenoy, S.] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA.
[Ryan, E.] Univ Minnesota, Dept Astron, Minneapolis, MN 55455 USA.
RP Mizuno, DR (reprint author), Boston Coll, Inst Sci Res, 140 Commonwealth Ave, Chestnut Hill, MA 02467 USA.
EM afrl.rvb.pa@hanscom.af.mil
OI Kraemer, Kathleen/0000-0002-2626-7155
NR 32
TC 35
Z9 35
U1 0
U2 1
PU IOP PUBLISHING LTD
PI BRISTOL
PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
SN 0004-6256
J9 ASTRON J
JI Astron. J.
PD APR
PY 2010
VL 139
IS 4
BP 1542
EP 1552
DI 10.1088/0004-6256/139/4/1542
PG 11
WC Astronomy & Astrophysics
SC Astronomy & Astrophysics
GA 568BO
UT WOS:000275496900023
ER
PT J
AU Iversen, P
McLeod, DG
See, WA
Morris, T
Armstrong, J
Wirth, MP
AF Iversen, Peter
McLeod, David G.
See, William A.
Morris, Thomas
Armstrong, Jon
Wirth, Manfred P.
CA Casodex Early Prostate Canc Triali
TI Antiandrogen monotherapy in patients with localized or locally advanced
prostate cancer: final results from the bicalutamide Early Prostate
Cancer programme at a median follow-up of 9.7 years
SO BJU INTERNATIONAL
LA English
DT Article
DE adjuvant; antiandrogen; bicalutamide; localized; locally advanced;
prostate cancer
ID ANDROGEN DEPRIVATION THERAPY; QUALITY-OF-LIFE; RADICAL PROSTATECTOMY;
STANDARD CARE; PELVIC LYMPHADENECTOMY; HORMONAL-THERAPY;
RANDOMIZED-TRIAL; 150 MG; ADJUVANT; MEN
AB OBJECTIVE
To evaluate the efficacy and tolerability of bicalutamide 150 mg once-daily as immediate hormonal therapy in patients with prostate cancer or as adjuvant to radical prostatectomy or radiotherapy.
PATIENTS AND METHODS
In all, 8113 patients with localized (T1-2, N0/Nx) or locally advanced (T3-4, any N; or any T, N+) prostate cancer (all M0) were enrolled in three complementary, double-blind, placebo-controlled trials. Patients were randomized to receive standard care plus either oral bicalutamide 150 mg once-daily or oral placebo. Primary endpoints were progression-free survival (PFS) and overall survival (OS). Data were collated from individual trials and evaluated in a combined analysis.
RESULTS
Overall, at a median follow-up of 9.7 years, bicalutamide significantly improved PFS (hazard ratio 0.85, 95% confidence interval 0.79-0.91; P = 0.001). Compared with placebo there was no difference in OS (hazard ratio 1.01, P = 0.77). Patients who derived benefit from bicalutamide in terms of PFS were those with locally advanced disease, with OS significantly favouring bicalutamide in patients with locally advanced disease undergoing radiotherapy (P = 0.031). Patients with localized disease showed no clinically or statistically significant improvements in PFS; there was a survival trend in favour of placebo in patients with localized disease undergoing watchful waiting (P = 0.054). The overall tolerability of bicalutamide was consistent with previous analyses, with breast pain (73.7%) and gynaecomastia (68.8%) the most frequently reported adverse events in patients randomized to bicalutamide.
CONCLUSIONS
Bicalutamide 150 mg, either as monotherapy or adjuvant to standard care, improved PFS in patients with locally advanced prostate cancer, but not in patients with localized disease. A pre-planned subset analysis showed a benefit for OS in patients with locally advanced disease undergoing radiotherapy. Bicalutamide 150 mg might represent an alternative for patients with locally advanced prostate cancer considering androgen-deprivation therapy.
C1 [Iversen, Peter] Univ Copenhagen, Dept Urol, Rigshosp, DK-2100 Copenhagen, Denmark.
[McLeod, David G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[See, William A.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
[Morris, Thomas; Armstrong, Jon] AstraZeneca, Macclesfield, Cheshire, England.
[Wirth, Manfred P.] Tech Univ Dresden, Dresden, Germany.
RP Iversen, P (reprint author), Univ Copenhagen, Dept Urol, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM peter.iversen@rh.regionh.dk
FU AstraZeneca
FX The EPC programme was funded by AstraZeneca. We thank Sarah Lewis, from
Complete Medical Communications, who provided medical writing support
funded by AstraZeneca. Casodex (R) and Zoladex (R) are registered
trademarks of the AstraZeneca group of companies. Clinical trial
registration numbers: Study 0023 (NCT00657904), Study 0024
(NCT00673205), Study 0025 (NCT00672282).
NR 25
TC 37
Z9 42
U1 0
U2 6
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1464-4096
J9 BJU INT
JI BJU Int.
PD APR
PY 2010
VL 105
IS 8
BP 1074
EP 1081
DI 10.1111/j.1464-410X.2010.09319.x
PG 8
WC Urology & Nephrology
SC Urology & Nephrology
GA 574SO
UT WOS:000276013800006
PM 22129214
ER
PT J
AU Pratt, WD
Wang, D
Nichols, DK
Luo, M
Woraratanadharm, J
Dye, JM
Holman, DH
Dong, JY
AF Pratt, William D.
Wang, Danher
Nichols, Donald K.
Luo, Min
Woraratanadharm, Jan
Dye, John M.
Holman, David H.
Dong, John Y.
TI Protection of Nonhuman Primates against Two Species of Ebola Virus
Infection with a Single Complex Adenovirus Vector
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID VACCINE PROTECTS; MARBURG VIRUS; HEMORRHAGIC-FEVER; RHESUS-MONKEYS;
GUINEA-PIGS; NEUTRALIZING ANTIBODIES; BIOLOGICAL WEAPONS;
IMMUNE-RESPONSES; CHALLENGE; SUDAN
AB Ebola viruses are highly pathogenic viruses that cause outbreaks of hemorrhagic fever in humans and other primates. To meet the need for a vaccine against the several types of Ebola viruses that cause human diseases, we developed a multivalent vaccine candidate (EBO7) that expresses the glycoproteins of Zaire ebolavirus (ZEBOV) and Sudan ebolavirus (SEBOV) in a single complex adenovirus-based vector (CAdVax). We evaluated our vaccine in nonhuman primates against the parenteral and aerosol routes of lethal challenge. EBO7 vaccine provided protection against both Ebola viruses by either route of infection. Significantly, protection against SEBOV given as an aerosol challenge, which has not previously been shown, could be achieved with a boosting vaccination. These results demonstrate the feasibility of creating a robust, multivalent Ebola virus vaccine that would be effective in the event of a natural virus outbreak or biological threat.
C1 [Pratt, William D.; Nichols, Donald K.; Dye, John M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Wang, Danher; Luo, Min; Woraratanadharm, Jan; Holman, David H.; Dong, John Y.] GenPhar Inc, Div Biodefense Vaccines, Mt Pleasant, SC 29464 USA.
[Dong, John Y.] Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA.
RP Pratt, WD (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM williamd.pratt@us.army.mil
FU Defense Threat Reduction Agency [1.1C0001_07_RD_B, DAMD17-02-2-0035]; U.
S. Public Health Service, National Institute of Allergy and Infectious
Diseases [AI070382]
FX We thank Carlton Rice for animal care and the staff of the Center for
Aerobiological Sciences, USAMRIID, particularly Mathew Lackemeyer, for
assistance with aerosol exposures. We also thank Ana Kuehne, Jay Wells,
and Ramon Ortiz for their technical assistance.; Work on filoviruses at
USAMRIID was funded by the Defense Threat Reduction Agency (project
number 1.1C0001_07_RD_B and Cooperative Agreement DAMD17-02-2-0035) and
in part by U. S. Public Health Service grant AI070382 from the National
Institute of Allergy and Infectious Diseases to J.Y.D.
NR 45
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U1 2
U2 10
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD APR
PY 2010
VL 17
IS 4
BP 572
EP 581
DI 10.1128/CVI.00467-09
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 576TG
UT WOS:000276170900013
PM 20181765
ER
PT J
AU Goo, R
Miller, M
McArthur, T
AF Goo, Roy
Miller, Michael
McArthur, Todd
TI Provider Compliance With the Food and Drug Administration Recommendation
to Avoid the Use of Over-the-Counter (Nonprescription) Cough and Cold
Medications in Children Younger Than 2 Years
SO CLINICAL PEDIATRICS
LA English
DT Article
C1 [Goo, Roy; Miller, Michael] Tripler Army Med Ctr, Honolulu, HI 96851 USA.
[McArthur, Todd] Madigan Army Med Ctr, Dept Emergency Med, Ft Lewis, WA USA.
RP Miller, M (reprint author), Tripler Army Med Ctr, 1 Jarett White Rd, Honolulu, HI 96851 USA.
EM michael.adam.miller@us.army.mil
NR 9
TC 1
Z9 1
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0009-9228
J9 CLIN PEDIATR
JI Clin. Pediatr.
PD APR
PY 2010
VL 49
IS 4
BP 384
EP 387
DI 10.1177/0009922809343719
PG 4
WC Pediatrics
SC Pediatrics
GA 577XD
UT WOS:000276256400013
PM 19745097
ER
PT J
AU Valisetty, R
Rajendran, A
Grove, D
AF Valisetty, R.
Rajendran, A.
Grove, D.
TI Mesh Effects in Predictions of Progressive Damage in 3D Woven Composites
SO CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
LA English
DT Article
DE Fabrics/textiles; Stress concentrations; Impact behavior; Damage
Mechanics
ID TRANSFORMATION FIELD ANALYSIS; IMPACT; MODEL; HOMOGENIZATION; FAILURE
AB A multi-scale model exhibiting progressive damage is considered for a 3D-woven composite. It is based on the evolution of some fundamental damage modes in a representative volume element (RVE) of a composite's woven architecture. The overall response of a woven composite due to a variety of damage modes is computationally obtained through a transformation field analysis (TFA) that is capable of quantifying the effects of spatial distribution of micro stresses and strains on strength. Since the model is computationally intensive, its numerical requirements are to be understood before it can successfully be used in design studies or in conjunction with Lagrangian explicit codes. This paper examines the effect of the local micro-mesh size on the progression of certain damage modes in 3D-woven composites and the predicted overall response.
C1 [Valisetty, R.; Grove, D.] USA, Comput & Inform Sci Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Rajendran, A.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA.
RP Valisetty, R (reprint author), USA, Comput & Inform Sci Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM raj@olemiss.edu
FU U.S. Army Research Office, Durham, NC
FX The authors are grateful to Dr. Yehia Bahei-El-Din, who is currently
with the British University, Cairo, Egypt, for his suggestions to the
manuscript. This work was partially funded by the U.S. Army Research
Office, Durham, NC. The simulations were performed in Army's MSRC at
Aberdeen Proving Ground, MD.
NR 25
TC 0
Z9 0
U1 0
U2 1
PU TECH SCIENCE PRESS
PI NORCROSS
PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA
SN 1526-1492
J9 CMES-COMP MODEL ENG
JI CMES-Comp. Model. Eng. Sci.
PD APR
PY 2010
VL 60
IS 1
BP 41
EP 71
PG 31
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications
SC Engineering; Mathematics
GA 643PU
UT WOS:000281311600002
ER
PT J
AU Ditman, T
Brunye, TT
Mahoney, CR
Taylor, HA
AF Ditman, Tali
Brunye, Tad T.
Mahoney, Caroline R.
Taylor, Holly A.
TI Simulating an enactment effect: Pronouns guide action simulation during
narrative comprehension
SO COGNITION
LA English
DT Article
DE Perspective-taking; Embodied cognition; Discourse comprehension;
Language; Action understanding
ID LANGUAGE COMPREHENSION; SITUATION MODELS; PERSPECTIVE-TAKING; MOTOR
RESONANCE; MEMORY; INFORMATION; REPRESENTATIONS; ACCESSIBILITY;
CONSTRUCTION; OBJECTS
AB Recent research has suggested that reading involves the mental simulation of events and actions described in a text. It is possible however that previous findings did not tap into processes engaged during natural reading but rather those triggered by task demands. The present study examined whether readers spontaneously mentally simulate the actions described in simple narratives by using a memory task that did not encourage the formation of mental images. During encoding, participants read event scenarios preceded by 'I', 'You', or 'He', and then 10 min (Experiment 1) or 3 days later (Experiment 2), we examined memory for action and descriptive elements of these scenarios. Given previous research demonstrating that readers simulate described actions preceded by 'You' from an actor's perspective, we predicted that such action statements would be better remembered than those preceded by 'He' or 'I' a simulated enactment effect. Results of both experiments supported this prediction; readers had better memory for actions but not descriptive information (10 min and 3 days later) after reading statements preceded by 'You'. Results demonstrate that readers spontaneously mentally simulate actions during language comprehension and take different mental perspectives, even when doing so is not necessary to perform the task. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Ditman, Tali; Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA.
[Ditman, Tali] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA.
[Brunye, Tad T.; Mahoney, Caroline R.] USA, NSRDEC, Natick, MA 01760 USA.
RP Ditman, T (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA.
EM tali.ditman@tufts.edu
RI 江, 鈺麒/G-1379-2014
NR 53
TC 28
Z9 29
U1 1
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
J9 COGNITION
JI Cognition
PD APR
PY 2010
VL 115
IS 1
BP 172
EP 178
DI 10.1016/j.cognition.2009.10.014
PG 7
WC Psychology, Experimental
SC Psychology
GA 576EF
UT WOS:000276126400017
PM 19939357
ER
PT J
AU Adley, MD
Frank, AO
Danielson, KT
Akers, SA
O'Daniel, JL
AF Adley, Mark D.
Frank, Andreas O.
Danielson, Kent T.
Akers, Stephen A.
O'Daniel, James L.
TI The virtual penetration laboratory: new developments for projectile
penetration in concrete
SO COMPUTERS AND CONCRETE
LA English
DT Article
DE penetration mechanics; constitutive modeling; evolutionary algorithms
ID MICROPLANE MODEL; STRESS
AB This paper discusses new capabilities developed for the Virtual Penetration Laboratory (VPL) software package to address the challenges of determining Penetration Resistance (PR) equations for concrete materials. Specifically, the paper introduces a three-invariant concrete constitutive model recently developed by the authors. The Advanced Fundamental Concrete (AFC) model was developed to provide a fast-running predictive model to simulate the behavior of concrete and other high-strength geologic materials. The Continuous Evolutionary Algorithms (CEA) automatic fitting algorithms used to fit the new model are discussed, and then examples are presented to demonstrate the effectiveness of the new AFC model. Finally, the AFC model in conjunction with the VPL software package is used to develop a PR equation for a concrete material.
C1 [Adley, Mark D.; Frank, Andreas O.; Danielson, Kent T.; Akers, Stephen A.; O'Daniel, James L.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
RP Adley, MD (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM mark.d.adley@usace.army.mil
NR 16
TC 3
Z9 3
U1 0
U2 3
PU TECHNO-PRESS
PI DAEJEON
PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA
SN 1598-8198
J9 COMPUT CONCRETE
JI Comput. Concr.
PD APR
PY 2010
VL 7
IS 2
SI SI
BP 87
EP 102
PG 16
WC Computer Science, Interdisciplinary Applications; Construction &
Building Technology; Engineering, Civil; Materials Science,
Characterization & Testing
SC Computer Science; Construction & Building Technology; Engineering;
Materials Science
GA 723ZH
UT WOS:000287545400002
ER
PT J
AU O'Daniel, J
Adley, M
Danielson, K
DiPaolo, B
Boone, N
AF O'Daniel, James
Adley, Mark
Danielson, Kent
DiPaolo, Beverly
Boone, Nicholas
TI Comparing finite element and meshfree particle formulations for
projectile penetration into fiber reinforced concrete
SO COMPUTERS AND CONCRETE
LA English
DT Article
DE Fiber Reinforced Concrete; finite element; meshfree; penetration
ID HYDRODYNAMICS; ALGORITHM
AB Penetration of a fragment-like projectile into Fiber Reinforced Concrete (FRC) was simulated using finite element (FE) and particle formulations. Extreme deformations and failure of the material during the penetration event were modeled with multiple approaches to evaluate how well each represented the actual physics of the penetration process and compared to experimental data. A Fragment Simulating Projectile (FSP) normally impacting a flat, square plate of FRC was modeled using two target thicknesses to examine the different levels of damage. The thinner plate was perforated by the FSP, while the thicker plate captured the FSP and only allowed penetration part way through the thickness. Full three dimensional simulations were performed, so the capability was present for non-symmetric FRC behavior and possible projectile rotation in all directions. These calculations assessed the ability of the finite element and particle formulations to calculate penetration response while assessing criteria necessary to perform the computations. The numerical code EPIC contains the element and particle formulations, as well as the explicit methodology and constitutive models, needed to perform these simulations.
C1 [O'Daniel, James; Adley, Mark] USAF, Res Lab, Eglin AFB, USA Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP O'Daniel, J (reprint author), USAF, Res Lab, Eglin AFB, USA Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM James.L.O'Daniel@usace.army.mil
NR 18
TC 1
Z9 1
U1 1
U2 4
PU TECHNO-PRESS
PI DAEJEON
PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA
SN 1598-8198
J9 COMPUT CONCRETE
JI Comput. Concr.
PD APR
PY 2010
VL 7
IS 2
SI SI
BP 103
EP 118
PG 16
WC Computer Science, Interdisciplinary Applications; Construction &
Building Technology; Engineering, Civil; Materials Science,
Characterization & Testing
SC Computer Science; Construction & Building Technology; Engineering;
Materials Science
GA 723ZH
UT WOS:000287545400003
ER
PT J
AU Littlefield, D
Walls, KC
Danielson, KT
AF Littlefield, David
Walls, Kenneth C.
Danielson, Kent T.
TI Integration of the microplane constitutive model into the EPIC code
SO COMPUTERS AND CONCRETE
LA English
DT Article
DE microplane model; constitutive model framework; EPIC code
ID CONCRETE; STRESS; STRAIN
AB In this work the implementation of a production-level port of the Microplane constitutive model for concrete into the EPIC code is described. The port follows guidelines outlined in the Material Model Module (MMM) standard used in EPIC to insure a seamless interface with the existing code. Certain features of the model were not implemented using the MMM interface due to compatibility reasons; for example, a separate module was developed to initialize, store and update internal state variables. Objective strain and deformation measures for use in the material model were also implemented into the code. Example calculations were performed and illustrate the veracity of this new implementation.
C1 [Littlefield, David] Univ Alabama, Dept Mech Engn, Birmingham, AL 35294 USA.
[Danielson, Kent T.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Littlefield, D (reprint author), Univ Alabama, Dept Mech Engn, Birmingham, AL 35294 USA.
EM littlefield@uab.edu
FU DoD
FX This work was supported by the DoD High Performance Computing
Modernization Program (HPCMP) under the Productivity Enhancement and
Technology Transfer (PET) Program.
NR 16
TC 2
Z9 2
U1 2
U2 3
PU TECHNO-PRESS
PI DAEJEON
PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA
SN 1598-8198
J9 COMPUT CONCRETE
JI Comput. Concr.
PD APR
PY 2010
VL 7
IS 2
SI SI
BP 145
EP 158
PG 14
WC Computer Science, Interdisciplinary Applications; Construction &
Building Technology; Engineering, Civil; Materials Science,
Characterization & Testing
SC Computer Science; Construction & Building Technology; Engineering;
Materials Science
GA 723ZH
UT WOS:000287545400005
ER
PT J
AU Danielson, KT
Adley, MD
O'Daniel, JL
AF Danielson, Kent T.
Adley, Mark D.
O'Daniel, James L.
TI Numerical procedures for extreme impulsive loading on high strength
concrete structures
SO COMPUTERS AND CONCRETE
LA English
DT Article
DE nonlinear finite element analysis; reinforced concrete; microplane
constitutive model; parallel computing
ID MICROPLANE MODEL; STRESS; STRAIN
AB This paper demonstrates numerical techniques for complex large-scale modeling with microplane constitutive theories for reinforced high strength concrete, which for these applications, is defined to be around the 7000 psi (48 MPa) strength as frequently found in protective structural design. Applications involve highly impulsive loads, such as an explosive detonation or impact-penetration event. These capabilities were implemented into the authors' finite element code, Para Able and the PRONTO 3D code from Sandia National Laboratories. All materials are explicitly modeled with eight-noded hexahedral elements. The concrete is modeled with a microplane constitutive theory, the reinforcing steel is modeled with the Johnson-Cook model, and the high explosive material is modeled with a JWL equation of state and a programmed burn model. Damage evolution, which can be used for erosion of elements and/or for post-analysis examination of damage, is extracted from the microplane predictions and computed by a modified Holmquist-Johnson-Cook approach that relates damage to levels of inelastic strain increment and pressure. Computation is performed with MPI on parallel processors. Several practical analyses demonstrate that large-scale analyses of this type can be reasonably run on large parallel computing systems.
C1 [Danielson, Kent T.; Adley, Mark D.; O'Daniel, James L.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Danielson, KT (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Kent.T.Danielson@us.army.mil
FU DOD at the ERDC DOD Supercomputing Resource Center (DSRC)
FX Permission to publish was granted by Director, Geotechnical and
Structures Laboratory. The work was supported in part by grants of
computer time from the DOD High Performance Computing Modernization
Program at the ERDC DOD Supercomputing Resource Center (DSRC).
NR 18
TC 5
Z9 5
U1 2
U2 5
PU TECHNO-PRESS
PI DAEJEON
PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA
SN 1598-8198
J9 COMPUT CONCRETE
JI Comput. Concr.
PD APR
PY 2010
VL 7
IS 2
SI SI
BP 159
EP 167
PG 9
WC Computer Science, Interdisciplinary Applications; Construction &
Building Technology; Engineering, Civil; Materials Science,
Characterization & Testing
SC Computer Science; Construction & Building Technology; Engineering;
Materials Science
GA 723ZH
UT WOS:000287545400006
ER
PT J
AU Roth, MJ
Slawson, TR
Flores, OG
AF Roth, M. Jason
Slawson, Thomas R.
Flores, Omar G.
TI Flexural and tensile properties of a glass fiber-reinforced
ultra-high-strength concrete: an experimental, micromechanical and
numerical study
SO COMPUTERS AND CONCRETE
LA English
DT Article
DE ultra-high-strength concrete; alkali resistant glass fiber;
micromechanical model; tensile failure function; finite element
analysis; concrete damage plasticity
ID CEMENT-BASED COMPOSITES; BEHAVIOR; FRACTURE; TOUGHNESS; INTERFACE; MODEL
AB The focus of this research effort was characterization of the flexural and tensile properties of a specific ultra-high-strength, fiber-reinforced concrete material. The material exhibited a mean unconfined compressive strength of approximately 140 MPa and was reinforced with short, randomly distributed alkali resistant glass fibers. As a part of the study, coupled experimental, analytical and numerical investigations were performed. Flexural and direct tension tests were first conducted to experimentally characterize material behavior. Following experimentation, a micromechanically-based analytical model was utilized to calculate the material's tensile failure response, which was compared to the experimental results. Lastly, to investigate the relationship between the tensile failure and flexural response, a numerical analysis of the flexural experiments was performed utilizing the experimentally developed tensile failure function. Results of the experimental, analytical and numerical investigations are presented herein.
C1 [Roth, M. Jason; Slawson, Thomas R.; Flores, Omar G.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Roth, MJ (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM michael.j.roth@usace.army.mil
NR 36
TC 4
Z9 4
U1 0
U2 3
PU TECHNO-PRESS
PI DAEJEON
PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA
SN 1598-8198
J9 COMPUT CONCRETE
JI Comput. Concr.
PD APR
PY 2010
VL 7
IS 2
SI SI
BP 169
EP 190
PG 22
WC Computer Science, Interdisciplinary Applications; Construction &
Building Technology; Engineering, Civil; Materials Science,
Characterization & Testing
SC Computer Science; Construction & Building Technology; Engineering;
Materials Science
GA 723ZH
UT WOS:000287545400007
ER
PT J
AU Williams, EM
Graham, SS
Akers, SA
Reed, PA
Rushing, TS
AF Williams, E. M.
Graham, S. S.
Akers, S. A.
Reed, P. A.
Rushing, T. S.
TI Constitutive property behavior of an ultra-high-performance concrete
with and without steel fibers
SO COMPUTERS AND CONCRETE
LA English
DT Article
DE ultra-high-performance concrete; steel fibers; mechanical response
AB A laboratory investigation was conducted to characterize the constitutive property behavior of Cor-Tuf, an ultra-high-performance composite concrete. Mechanical property tests (hydrostatic compression, unconfined compression (UC), triaxial compression (TXC), unconfined direct pull (DP), uniaxial strain, and uniaxial-strain-load/constant-volumetric-strain tests) were performed on specimens prepared from concrete mixtures with and without steel fibers. From the UC and TXC test results, compression failure surfaces were developed for both sets of specimens. Both failure surfaces exhibited a continuous increase in maximum principal stress difference with increasing confining stress. The DP tests results determined the unconfined tensile strengths of the two mixtures. The tensile strength of each mixture was less than the generally assumed tensile strength for conventional strength concrete, which is 10 percent of the unconfined compressive strength. Both concretes behaved similarly, but Cor-Tuf with steel fibers exhibited slightly greater strength with increased confining pressure, and Cor-Tuf without steel fibers displayed slightly greater compressibility.
C1 [Williams, E. M.; Graham, S. S.; Akers, S. A.; Reed, P. A.; Rushing, T. S.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS USA.
RP Williams, EM (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS USA.
EM erin.m.williams@usace.army.mil
NR 5
TC 11
Z9 11
U1 0
U2 3
PU TECHNO-PRESS
PI DAEJEON
PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA
SN 1598-8198
J9 COMPUT CONCRETE
JI Comput. Concr.
PD APR
PY 2010
VL 7
IS 2
SI SI
BP 191
EP 202
PG 12
WC Computer Science, Interdisciplinary Applications; Construction &
Building Technology; Engineering, Civil; Materials Science,
Characterization & Testing
SC Computer Science; Construction & Building Technology; Engineering;
Materials Science
GA 723ZH
UT WOS:000287545400008
ER
PT J
AU Chung, K
Renz, EM
Cancio, LC
Wolf, S
AF Chung, Kevin
Renz, Evan M.
Cancio, Leopoldo C.
Wolf, Steven
TI Regarding critical care of the burn patient: The first 48 hours
SO CRITICAL CARE MEDICINE
LA English
DT Letter
ID RESUSCITATION; FLUID
C1 [Chung, Kevin; Renz, Evan M.; Cancio, Leopoldo C.] USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA.
[Wolf, Steven] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
RP Chung, K (reprint author), USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA.
OI Wolf, Steven/0000-0003-2972-3440
NR 5
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
J9 CRIT CARE MED
JI Crit. Care Med.
PD APR
PY 2010
VL 38
IS 4
BP 1225
EP 1225
DI 10.1097/CCM.0b013e3181cd0f87
PG 1
WC Critical Care Medicine
SC General & Internal Medicine
GA 581CW
UT WOS:000276499700035
PM 20335710
ER
PT J
AU Henning, JS
Firoz, BF
AF Henning, J. Scott
Firoz, Bahar F.
TI The Use of a Cooling Device as an Analgesic Before Injectable Local
Anesthesia in the Pediatric Population
SO DERMATOLOGIC SURGERY
LA English
DT Article
ID EMERGENCY-DEPARTMENT; ETHYL CHLORIDE; INTRAVENOUS CANNULATION;
VAPOCOOLANT SPRAY; PAIN; CHILDREN; VENIPUNCTURE; INSERTION; PLACEBO
C1 [Henning, J. Scott] Brooke Army Med Ctr, Houston, TX USA.
[Firoz, Bahar F.] Univ Texas Hlth Sci Ctr San Antonio, Dept Dermatol & Mohs Surg, San Antonio, TX 78229 USA.
RP Henning, JS (reprint author), Dept Dermatol, 3851 Roger Brooke Dr, Houston, TX 78251 USA.
EM Jeffrey.henning@lackland.af.mil
NR 17
TC 2
Z9 2
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1076-0512
J9 DERMATOL SURG
JI Dermatol. Surg.
PD APR
PY 2010
VL 36
IS 4
BP 520
EP 523
DI 10.1111/j.1524-4725.2010.01487.x
PG 4
WC Dermatology; Surgery
SC Dermatology; Surgery
GA 576SL
UT WOS:000276168500013
PM 20187896
ER
PT J
AU Bennett, JW
Mende, K
Herrera, ML
Yu, X
Lewis, JS
Wickes, BL
Jorgensen, JH
Murray, CK
AF Bennett, Jason W.
Mende, Katrin
Herrera, Monica L.
Yu, Xin
Lewis, James S., II
Wickes, Brian L.
Jorgensen, James H.
Murray, Clinton K.
TI Mechanisms of carbapenem resistance among a collection of
Enterobacteriaceae clinical isolates in a Texas city
SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
LA English
DT Article
DE Carbapenem; Enterobacteriaceae; Extended spectrum beta-lactamases;
KPC-2; AmpC beta-lactamase; Porins; Texas city
ID SPECTRUM BETA-LACTAMASES; KLEBSIELLA-PNEUMONIAE CARBAPENEMASE;
GRAM-NEGATIVE BACTERIA; ESCHERICHIA-COLI; PORIN; EXPRESSION; EMERGENCE;
ENTEROBACTETIACEAE; CEPHALOSPORINS; ERTAPENEM
AB Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum beta-lactamase or AmpC beta-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC beta-lactamase, 1 Escherichia colt expressed plasmid-mediated AmpC beta-lactamase, and 1 E. cloacae produced a carbapenemase. Published by Elsevier Inc.
C1 [Bennett, Jason W.; Mende, Katrin; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA.
[Mende, Katrin] Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Herrera, Monica L.; Wickes, Brian L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.
[Yu, Xin] San Antonio Mil Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[Lewis, James S., II] Univ Hlth Syst, Dept Pharm, San Antonio, TX 78229 USA.
[Jorgensen, James H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA.
RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
EM clinton.murray@amedd.army.mil
RI Valle, Ruben/A-7512-2013
NR 25
TC 8
Z9 9
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0732-8893
J9 DIAGN MICR INFEC DIS
JI Diagn. Microbiol. Infect. Dis.
PD APR
PY 2010
VL 66
IS 4
BP 445
EP 448
DI 10.1016/j.diagmicrobio.2009.11.013
PG 4
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA 574FD
UT WOS:000275973200016
PM 20226336
ER
PT J
AU Wilk, JE
Bliese, PD
Kim, PY
Thomas, JL
McGurk, D
Hoge, CW
AF Wilk, Joshua E.
Bliese, Paul D.
Kim, Paul Y.
Thomas, Jeffrey L.
McGurk, Dennis
Hoge, Charles W.
TI Relationship of combat experiences to alcohol misuse among US soldiers
returning from the Iraq war
SO DRUG AND ALCOHOL DEPENDENCE
LA English
DT Article
DE Alcohol misuse; Combat; Military
ID UK ARMED-FORCES; POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS;
GENERAL-POPULATION; TRAUMATIC EVENTS; SELF-REPORTS; CONSEQUENCES;
CONSISTENCY; VETERANS; CARE
AB Objective: Studies have shown a relationship between combat experiences and alcohol misuse in military personnel; it is not known if there are specific combat experiences that confer a greater risk. The current study examined the association of specific types of combat experiences with a positive screen for alcohol misuse.
Methods: 1120 U.S. soldiers who were members of brigade combat infantry teams were surveyed anonymously 3-4 months after returning from deployment to Iraq regarding their experiences in combat and their physical and mental health. Combat items were independently rated and placed into the following categories: (1) Fighting; (2) Killing; (3) Threat to oneself; (4) Death/injury of others; (5) Atrocities; and, (6) Positive experiences. Alcohol misuse was measured using a 2-item alcohol screen combined with alcohol-related behavioral items.
Results: Of the soldiers sampled, 25% (N=275) screened positive for alcohol misuse 3-4 months post-deployment; 12% (N = 125) screened positive and exhibited alcohol-related behavioral problems. Most combat exposure factors were significantly related to alcohol misuse individually. When factors were analyzed simultaneously, soldiers who had higher rates of exposure to the threat of death/injury were significantly more likely to screen positive for alcohol misuse; exposure to atrocities predicted misuse of alcohol with alcohol-related behavioral problems.
Conclusions: High exposure to threatening situations and atrocities was associated with a positive screen for alcohol misuse. Clinicians treating combat veterans should be aware of the potential association of alcohol misuse with specific types of experiences and closely follow those soldiers upon their return home. Published by Elsevier Ireland Ltd.
C1 [Wilk, Joshua E.; Bliese, Paul D.; Kim, Paul Y.; Thomas, Jeffrey L.; Hoge, Charles W.] USA, Med Res & Mat Command, Div Psychiat & Neurosci, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
USA, Med Res Unit Europe, Walter Reed Army Inst Res, Med Res & Mat Command, APO, AE 09042 USA.
RP Wilk, JE (reprint author), USA, Med Res & Mat Command, Div Psychiat & Neurosci, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM joshua.wilk@amedd.army.mil
NR 29
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U1 1
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0376-8716
J9 DRUG ALCOHOL DEPEN
JI Drug Alcohol Depend.
PD APR 1
PY 2010
VL 108
IS 1-2
BP 115
EP 121
DI 10.1016/j.drugalcdep.2009.12.003
PG 7
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA 579NB
UT WOS:000276376600016
PM 20060237
ER
PT J
AU Dean, TR
Hromadka, TV
AF Dean, T. R.
Hromadka, T. V., II
TI A collocation CVBEM using program Mathematica
SO ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
LA English
DT Article
DE CVBEM; Complex variable boundary elements; Collocation; Complex
variables
AB The well-known complex variable boundary element method (CVBEM) is extended for using collocation points not located at the usual boundary nodal point locations. In this work, several advancements to the implementation of the CVBEM are presented. The first advancement is enabling the CVBEM nodes to vary in location, impacting the modeling accuracy depending on chosen node locations. A second advancement is determining values of the CVBEM basis function complex coefficients by collocation at evaluation points defined on the problem boundary but separate and distinct from nodal point locations (if some or all nodes are located on the problem boundary). A third advancement is the implementation of these CVBEM modeling features on computer program Mathematica, in order to reduce programming requirements and to take advantage of Mathematica's library of mathematical capabilities and graphics features. Published by Elsevier Ltd.
C1 [Hromadka, T. V., II] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
[Dean, T. R.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
NR 4
TC 5
Z9 5
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0955-7997
J9 ENG ANAL BOUND ELEM
JI Eng. Anal. Bound. Elem.
PD APR
PY 2010
VL 34
IS 4
BP 417
EP 422
DI 10.1016/j.enganabound.2009.10.007
PG 6
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications
SC Engineering; Mathematics
GA 561UA
UT WOS:000275003500012
ER
PT J
AU Cerco, CF
Tillman, D
Hagy, JD
AF Cerco, Carl F.
Tillman, Dorothy
Hagy, James D.
TI Coupling and comparing a spatially- and temporally-detailed
eutrophication model with an ecosystem network model: An initial
application to Chesapeake Bay
SO ENVIRONMENTAL MODELLING & SOFTWARE
LA English
DT Article
DE CE-QUAL-ICM; Ecopath; Eutrophication; Chesapeake Bay; Atlantic menhaden;
Phytoplankton
AB Coastal waters are modeled for a variety of purposes including eutrophication remediation and fisheries management. Combining these two approaches provides insights which are not available from either approach independently. Coupling is confounded, however, by differences in model formulations and "currencies." We present here an initial coupling of a spatially- and temporally-detailed eutrophication model, CE-QUAL-ICM, with a network fisheries model, Ecopath. We list commonalities between the models and present algorithms and software for the exchange of information. The models are applied to the central portion of Chesapeake Bay for a contemporary summer period. After comparison of the representations of Chesapeake Bay by the two models, an illustrative example one-way, off-line, coupling is presented. In an initial examination of a 20% increase in predation on phytoplankton by a small, highly-exploited fish (Atlantic menhaden, Brevoortia tyrannus), computed reduction in phytoplankton biomass is accompanied by increased production due to enhanced nutrient recycling. Minimal impact on the structure of the food web or on biomass of higher-trophic level organisms is computed. The algorithms and software can be adapted to alternate eutrophication models and Ecopath applications and provide the first, necessary, steps for subsequent coupling with the time-variable Ecosim model. Published by Elsevier Ltd.
C1 [Cerco, Carl F.; Tillman, Dorothy] USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA.
[Hagy, James D.] US EPA, Gulf Breeze, FL 32561 USA.
RP Cerco, CF (reprint author), USA, Ctr Res Dev & Engn, Mail Stop EP W,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM carl.f.cerco@usace.army.mil
FU US Army Engineers System-Wide Water Resources Program (SWRRP)
FX Funding for this investigation was provided by the US Army Engineers
System-Wide Water Resources Program (SWRRP) under the Ecological
Modeling Focus Area. For more information on SWRRP, please consult
https://swwrp.usace.army.mil/Improvements to an earlier version of this
manuscript were guided by helpful comments from the editor and two
reviewers. Reviewer 1 suggested the hierarchy of couplings described
here.
NR 31
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U1 2
U2 36
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1364-8152
EI 1873-6726
J9 ENVIRON MODELL SOFTW
JI Environ. Modell. Softw.
PD APR
PY 2010
VL 25
IS 4
BP 562
EP 572
DI 10.1016/j.envsoft.2009.09.008
PG 11
WC Computer Science, Interdisciplinary Applications; Engineering,
Environmental; Environmental Sciences
SC Computer Science; Engineering; Environmental Sciences & Ecology
GA 553FB
UT WOS:000274350400017
ER
PT J
AU Savard, K
Sarrazin, M
Dodard, SG
Monteil-Rivera, F
Kuperman, RG
Hawari, J
Sunahara, GI
AF Savard, Kathleen
Sarrazin, Manon
Dodard, Sabine G.
Monteil-Rivera, Fanny
Kuperman, Roman G.
Hawari, Jalal
Sunahara, Geoffrey I.
TI ROLE OF SOIL INTERSTITIAL WATER IN THE ACCUMULATION OF
HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE IN THE EARTHWORM EISENIA ANDREI
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Hexahydro-1,3,5-trinitro-1,3,5-triazine; Bioaccumulation;
Bioavailability; Bioconcentration; Equilibrium partitioning
ID SANDY LOAM SOIL; HETEROCYCLIC EXPLOSIVES RDX; ORGANIC-CHEMICALS;
BIOACCUMULATION; TOXICITY; REPRODUCTION; HMX; BIOAVAILABILITY;
OLIGOCHAETA; SURVIVAL
AB The uptake of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) from soil by the earthworm Eisenia andrei was examined by using the equilibrium partitioning (EqP) theory and a three-compartment model including soil (S), interstitial water (IW), and earthworms (E). The RDX concentrations were measured using U.S. Environmental Protection Agency (U.S. EPA) Method 8330A and high-performance liquid chromatography (HPLC). The S-IW studies were conducted using four natural soils with contrasting physicochemical properties that were hypothesized to affect the bioavailability of RDX. Each soil was amended with nominal RDX concentrations ranging from 1 to 10,000 mg/kg. The HPLC analysis showed that the IW extracted from soil was saturated with RDX at 80 mg/kg or greater soil concentrations. The calculated S-IW coefficient (K(p)) values for RDX ranged from 0.4 to 1.8 ml/g soil, depending on the soil type, and were influenced by the organic matter content. In the IW-E studies, earthworms were exposed to nonlethal RDX concentrations in aqueous media. The uptake of RDX by the earthworms correlated well (r(2) = 0.99) with the dissolved RDX concentrations. For the E-S studies, earthworms were exposed to RDX-amended soils used in the S-IW studies. The bioconcentration factors (BCF; ratios of E-to-IW RDX concentrations) were relatively constant (similar to 5) up to 80 mg/kg soil RDX concentrations, which encompass the RDX saturation limit in the interstitial water of the tested soils. At this concentration range, the RDX uptake from interstitial water was likely dominated by passive diffusion and could be used as an indicator of bioavailability. Other mechanisms may be involved at greater RDX soil concentrations. Environ. Toxicol. Chem. 2010;29:998-1005. (C) 2009 SETAC
C1 [Savard, Kathleen; Sarrazin, Manon; Dodard, Sabine G.; Monteil-Rivera, Fanny; Hawari, Jalal; Sunahara, Geoffrey I.] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada.
[Kuperman, Roman G.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Sunahara, GI (reprint author), Natl Res Council Canada, Biotechnol Res Inst, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, Canada.
EM geoffrey.sunahara@cnrc-nrc.gc.ca
RI Kuperman, Roman/D-4297-2009;
OI Kuperman, Roman/0000-0001-5344-1633
FU U.S. Department of Defense [ER-1256, ER-1416]; Defence Research and
Development Canada, Valcartier
FX This research project was supported by the U.S. Department of Defense
through the Strategic Environmental Research and Development Program
(SERDP Projects ER-1256 and ER-1416) and by the Defence Research and
Development Canada, Valcartier. The authors offer special thanks to
Sonia Thiboutot and Guy Ampleman for their continuing support of this
project and to Louise Paquet for her analytical support. This
publication was assigned National Research Council-Canada NRC 50001.
NR 42
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U1 1
U2 15
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD APR
PY 2010
VL 29
IS 4
BP 998
EP 1005
DI 10.1002/etc.113
PG 8
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 582NI
UT WOS:000276604100029
PM 20821531
ER
PT J
AU Ignaccolo, M
Latka, M
West, BJ
AF Ignaccolo, M.
Latka, M.
West, B. J.
TI Detrended fluctuation analysis of scaling crossover effects
SO EPL
LA English
DT Article
ID HEART-RATE DYNAMICS; TIME-SERIES
AB Detrended fluctuation analysis (DFA) is one of the most frequently used fractal time series algorithms. DFA has also become the tool of choice for analysis of the short-time fluctuations despite the fact that its validity in this domain has never been demonstrated. We adopt an Ornstein-Uhlenbeck Langevin equation to generate a time series which exhibits short-time power-law scaling and incorporates the fundamental property of physiological control systems-negative feedback. To determine the scaling exponent, we derive the analytical expressions for the standard deviation of the solution X(t) of this equation using both the ensemble of statistically independent trajectories and the ensemble obtained by partitioning a single trajectory. The latter approach is used in DFA and many other physiological applications. Surprisingly, the formulas for the standard deviations are different for these two ensembles. We demonstrate that the partitioning amounts to building up deterministic trends that satisfy the "trend + signal" decomposition assumption which is characteristic of DFA. Consequently, the dependence of the rms of DFA residuals F(tau) on the length tau of data window is the same for both ensembles. The growth of F(tau) is significantly different from that of the standard deviation of X(t). While the DFA estimate of the short-time scaling exponent is correct, the polynomial detrending delays the approach of F(tau) to the asymptotic value by as much as an order of magnitude. This delay may underlie the gradual change of the DFA scaling index typically observed in time series that exhibit crossover between the short- and long-time scaling. Copyright (C) EPLA, 2010
C1 [Latka, M.] Wroclaw Univ Technol, Inst Biomed Engn, PL-50370 Wroclaw, Poland.
[Ignaccolo, M.] Duke Univ, Dept Phys, Durham, NC 27708 USA.
[West, B. J.] USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA.
RP Ignaccolo, M (reprint author), Wroclaw Univ Technol, Inst Biomed Engn, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland.
EM Miroslaw.Latka@pwr.wroc.pl
FU U.S. Army Research Office
FX MI thanks the U.S. Army Research Office for support of this research. We
thank a referee for suggesting the two-walker interpretation of STE
averaging.
NR 29
TC 6
Z9 6
U1 0
U2 3
PU EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY
PI MULHOUSE
PA 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE
SN 0295-5075
EI 1286-4854
J9 EPL-EUROPHYS LETT
JI EPL
PD APR
PY 2010
VL 90
IS 1
AR 10009
DI 10.1209/0295-5075/90/10009
PG 6
WC Physics, Multidisciplinary
SC Physics
GA 615FJ
UT WOS:000279118900009
ER
PT J
AU Kimberley, J
Lambros, J
Chasiotis, I
Pulskamp, J
Polcawich, R
Dubey, M
AF Kimberley, J.
Lambros, J.
Chasiotis, I.
Pulskamp, J.
Polcawich, R.
Dubey, M.
TI A Hybrid Experimental/Numerical Investigation of the Response of
Multilayered MEMS Devices to Dynamic Loading
SO EXPERIMENTAL MECHANICS
LA English
DT Article
DE MEMS; Dynamic loading; SHPB; High speed imaging; Failure
ID RELIABILITY
AB In order to probe the mechanical response of microelectromechanical systems (MEMS) subjected to dynamic loading, a modified split Hopkinson pressure bar was used to load MEMS devices at accelerations ranging from 10(3)-10(5) g. Multilayer beams consisting of a PZT film sandwiched between two metal electrodes atop an elastic layer of silicon dioxide were studied because of their relevance to active MEMS devices. Experiments were conducted using the modified split Hopkinson pressure bar to quantify the effects of dynamic loading amplitude, duration, and temporal profile on the failure of the multilayered cantilever beams. Companion finite element simulations of these beams, informed by experimental measurements, were conducted to shed light into the deformation of the multilayered beams. Results of the numerical simulations were then coupled with independent experimental measurements of failure stress in order to predict the material layer at which failure initiation occurred, and the associated time to failure. High-speed imaging was also used to capture the first real-time images of MEMS structures responding to dynamic loading and successfully compare the recorded failure event with those predicted numerically.
C1 [Kimberley, J.; Lambros, J.; Chasiotis, I.] Univ Illinois, Urbana, IL 61801 USA.
[Pulskamp, J.; Polcawich, R.; Dubey, M.] USA, Res Labs, Adelphi, MD USA.
RP Lambros, J (reprint author), Univ Illinois, Urbana, IL 61801 USA.
EM lambros@illinois.edu
FU Army Research Office (ARO) [W911NF-05-1-0063]; National Science
Foundation [CMS-0555787]; US Department of Energy [DEFG02-91-ER45439]
FX The authors would like to acknowledge the support of the Army Research
Office (ARO) under the Grant W911NF-05-1-0063 with Dr. Bruce LaMattina
as the program manager, and the support by the National Science
Foundation under Grant CMS-0555787. Electron microscopy was carried out
in the Center for Microanalysis of Materials, University of Illinois,
which is partially supported by the US Department of Energy under grant
DEFG02-91-ER45439. The authors would also like to thank Richard Piekarz,
John Conrad, and Joel Martin of the Army Research Laboratory along with
Prashant Ranade of General Technical Services for their assistance in
the fabrication of the MEMS devices.
NR 19
TC 3
Z9 3
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4851
J9 EXP MECH
JI Exp. Mech.
PD APR
PY 2010
VL 50
IS 4
BP 527
EP 544
DI 10.1007/s11340-009-9259-0
PG 18
WC Materials Science, Multidisciplinary; Mechanics; Materials Science,
Characterization & Testing
SC Materials Science; Mechanics
GA 568TY
UT WOS:000275547000011
ER
PT J
AU Jackson, WM
Nesti, LJ
Tuan, RS
AF Jackson, Wesley M.
Nesti, Leon J.
Tuan, Rocky S.
TI Potential therapeutic applications of muscle-derived mesenchymal stem
and progenitor cells
SO EXPERT OPINION ON BIOLOGICAL THERAPY
LA English
DT Review
DE MPCs; MSCs; regenerative medicine; skeletal muscle stem cells; tissue
engineering
ID HUMAN SKELETAL-MUSCLE; HUMAN TRABECULAR BONE; VIVO GENE-THERAPY;
MYOGENIC ENDOTHELIAL-CELLS; MORPHOGENETIC PROTEIN 4; REGENERATIVE
MEDICINE; IMMUNOLOGICAL-PROPERTIES; TECHNOLOGY INSIGHT; CARTILAGE
REPAIR; DENTAL-TISSUES
AB Importance of the field: Mesenchymal adult stem cells have properties that make them attractive for use in tissue engineering and regenerative medicine. They are inherently plastic, enabling them to differentiate along different lineages, and promote wound healing and regeneration of surrounding tissues by modulating immune and inflammatory responses, promoting angiogenesis and secreting other trophic factors. Unlike embryonic stem cells, clinical uses of mesenchymal stem cells are not encumbered by ethical considerations or legal restrictions.
Areas covered in this review: We discuss skeletal muscle as a source of mesenchyma I stem and progenitor cells by reviewing their biology and current applications in tissue engineering and regenerative medicine. This paper covers literature from the last 5 - 10 years.
What the reader will gain: Skeletal muscle is a plentiful source of mesenchymal stem and progenitor cells. This tissue may be obtained via routine biopsy or collection after surgical debridement. We describe the biology of these cells and provide an overview of therapeutic applications currently being developed to take advantage of their regenerative properties.
Take home message: There is potential for stem and progenitor cells derived from skeletal muscle to be incorporated in clinical interventions, either as a cellular therapy to modify the natural history of disease or as a component of engineered tissue constructs that can replace diseased or damaged tissues.
C1 [Tuan, Rocky S.] Univ Pittsburgh, Sch Med, Ctr Cellular & Mol Engn, Dept Orthopaed Surg, Pittsburgh, PA 15232 USA.
[Jackson, Wesley M.; Nesti, Leon J.; Tuan, Rocky S.] NIAMSD, NIH, Cartilage Biol & Orthopaed Branch, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Jackson, Wesley M.; Nesti, Leon J.] NIAMSD, NIH, Dept Hlth & Human Serv, Clin & Expt Orthopaed Lab, Bethesda, MD 20892 USA.
[Nesti, Leon J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA.
RP Tuan, RS (reprint author), Univ Pittsburgh, Sch Med, Ctr Cellular & Mol Engn, Dept Orthopaed Surg, 450 Technol Dr,Room 221, Pittsburgh, PA 15232 USA.
EM rst13@pitt.edu
FU Military Amputee Research Program [P05-A011]; Comprehensive
Neurosciences Program [CNP-2008-CR01]; NIH [Z01 AR41131]
FX LJ Nesti has received funding from the Military Amputee Research Program
#P05-A011 and Comprehensive Neurosciences Program #CNP-2008-CR01. RS
Tuan received NIH intramural Support (Z01 AR41131).
NR 117
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U1 4
U2 20
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1471-2598
J9 EXPERT OPIN BIOL TH
JI Expert Opin. Biol. Ther.
PD APR
PY 2010
VL 10
IS 4
BP 505
EP 517
DI 10.1517/14712591003610606
PG 13
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 582CQ
UT WOS:000276573500003
PM 20218920
ER
PT J
AU Weiss, BM
Kuehl, WM
AF Weiss, Brendan M.
Kuehl, W. Michael
TI Advances in understanding monoclonal gammopathy of undetermined
significance as a precursor of multiple myeloma
SO EXPERT REVIEW OF HEMATOLOGY
LA English
DT Review
DE MGUS; monoclonal gammopathy of undetermined significance; multiple
myeloma; pathogenesis
ID LIGHT-CHAIN RATIO; INDEPENDENT RISK-FACTOR; PLASMA-CELL DISORDERS;
SIGNIFICANCE MGUS; NATURAL-HISTORY; WORKING GROUP; 1ST-DEGREE RELATIVES;
MARROW ANGIOGENESIS; PRIMARY AMYLOIDOSIS; PESTICIDE EXPOSURE
AB Monoclonal gammopathy of undetermined significance (MGUS) affects at least 3% of the population above the age of 50 and is the precursor to multiple myeloma (MM), an incurable malignancy of plasma cells. Recent advances in MGUS include: an improved understanding of the pathogenesis of MGUS and its progression to MM, involving molecular events intrinsic to the malignant plasma cell as well as the microenvironment; novel techniques to assess risk for progression to MM using serum-free light-chain analysis and immunophenotyping; and a renewed interest in chemoprevention of MM. In the future, continued improvement in our understanding of MGUS will lead to the development of better biomarkers for prognosis and therapies for chemoprevention of MM.
C1 [Weiss, Brendan M.] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA.
[Kuehl, W. Michael] NCI, Genet Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
RP Weiss, BM (reprint author), Walter Reed Army Med Ctr, Hematol Oncol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM brendan.weiss@us.army.mil
FU NIH, National Cancer Institute, Center for Cancer Research; Binding
Site, Inc., Birmingham, UK
FX The views expressed in this article are those of the authors and do not
necessarily reflect the official policy or position of the Department of
the Army, nor the US Government. W Michael Kuehl is supported by the
Intramural Research Program of the NIH, National Cancer Institute,
Center for Cancer Research. Other research support was provided by The
Binding Site, Inc., Birmingham, UK. The authors have no other relevant
affiliations or financial involvement with any organization or entity
with a financial interest in or financial conflict with the subject
matter or materials discussed in the manuscript apart from those
disclosed.
NR 75
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U1 1
U2 5
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1747-4086
J9 EXPERT REV HEMATOL
JI Expert Rev. Hematol.
PD APR
PY 2010
VL 3
IS 2
BP 165
EP 174
DI 10.1586/EHM.10.13
PG 10
WC Hematology
SC Hematology
GA 687TT
UT WOS:000284801500010
PM 20473362
ER
PT J
AU Andaya, JM
Hernandez, CA
Sato, AK
Uyehara, CFT
AF Andaya, January May
Hernandez, Claudia A.
Sato, Aileen K.
Uyehara, Catherine F. T.
TI Sex differences in estrogen receptor mediation of vasopressin synthesis
and release in rats chronically exposed to alcohol
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Andaya, January May] Univ Hawaii Manoa, Honolulu, HI 96822 USA.
[Andaya, January May; Hernandez, Claudia A.; Sato, Aileen K.; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675503692
ER
PT J
AU Andersen, NE
Karl, JP
Diaz, JE
Cable, SJ
Williams, KW
Rood, JC
Young, AJ
Lieberman, HR
McClung, JP
AF Andersen, Nancy Ellen
Karl, J. Philip
Diaz, Jennifer E.
Cable, Sonya J.
Williams, Kelly W.
Rood, Jennifer C.
Young, Andrew J.
Lieberman, Harris R.
McClung, James P.
TI Changes in vitamin D status of female Soldiers during basic combat
training
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Andersen, Nancy Ellen; Karl, J. Philip; Diaz, Jennifer E.; Young, Andrew J.; Lieberman, Harris R.; McClung, James P.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA.
[Rood, Jennifer C.] Pennington Biomed Res Ctr, Baton Rouge, LA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675501508
ER
PT J
AU Baer, L
Pidcoke, H
Wu, XW
Silliman, D
Walters, T
Tou, J
Wolf, S
Wade, C
AF Baer, Lisa
Pidcoke, Heather
Wu, Xiaowu
Silliman, David
Walters, Thomas
Tou, Janet
Wolf, Steven
Wade, Charles
TI Effects of Daily Insulin Treatment on Bone in Rats Following Severe Burn
and Disuse
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Baer, Lisa; Pidcoke, Heather; Wu, Xiaowu; Silliman, David; Walters, Thomas; Wolf, Steven; Wade, Charles] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Tou, Janet] W Virginia Univ, Morgantown, WV 26506 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675501793
ER
PT J
AU Carbone, JW
Pasiakos, SM
Vislocky, LM
Anderson, JM
Rodriguez, NR
AF Carbone, John W.
Pasiakos, Stefan M.
Vislocky, Lisa M.
Anderson, Jeffrey M.
Rodriguez, Nancy R.
TI Moderate energy deprivation increases caspase-3 activity and fractional
breakdown rate in human skeletal muscle
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Carbone, John W.] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA.
[Pasiakos, Stefan M.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Vislocky, Lisa M.; Anderson, Jeffrey M.; Rodriguez, Nancy R.] Univ Connecticut, Storrs, CT USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675504543
ER
PT J
AU Darlington, DN
Kheirabadi, BS
Martini, WZ
Dubick, MA
AF Darlington, Daniel Norman
Kheirabadi, Bijan S.
Martini, Wenjun Z.
Dubick, Michael A.
TI Hemorrhagic-induced acidosis does not affect recombinant Factor VIIa
(rFVIIa) function in Swine
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Darlington, Daniel Norman; Kheirabadi, Bijan S.; Martini, Wenjun Z.; Dubick, Michael A.] USA, Inst Surg Res, DCRP, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675505878
ER
PT J
AU DeGroot, DW
Ely, MR
Karl, JP
Young, AJ
AF DeGroot, David W.
Ely, Matthew R.
Karl, J. Philip
Young, Andrew J.
TI Altered substrate utilization during sequential short-term under- and
over-feeding
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [DeGroot, David W.; Ely, Matthew R.; Karl, J. Philip; Young, Andrew J.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675501171
ER
PT J
AU Dubick, MA
Mase, VJ
Barr, JL
Grubbs, DL
Roe, JL
Walters, TJ
AF Dubick, Michael A.
Mase, Vincent J., Jr.
Barr, Johnny L.
Grubbs, Dana L.
Roe, Janet L.
Walters, Thomas J.
TI Effect of skeletal muscle ischemia-reperfusion (I/R) post-conditioning
(Post C) on antioxidant status in rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Dubick, Michael A.; Mase, Vincent J., Jr.; Barr, Johnny L.; Grubbs, Dana L.; Roe, Janet L.; Walters, Thomas J.] USA, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675501536
ER
PT J
AU Gribok, AV
Rumpler, WV
Hoyt, R
Buller, M
AF Gribok, Andrei V.
Rumpler, William V.
Hoyt, Reed
Buller, Mark
TI A method to estimate instantaneous rates of gas exchange in indirect
calorimetry
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Gribok, Andrei V.; Rumpler, William V.] Beltsville Human Nutr Res Ctr, Food Intake & Energy Regulat Lab, Beltsville, MD USA.
[Hoyt, Reed; Buller, Mark] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675505220
ER
PT J
AU Hammamieh, R
Jett, M
AF Hammamieh, Rasha
Jett, Marti
TI Systems biology approaches to characterize exposures to infectious
agents
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675504300
ER
PT J
AU Jackson, SJT
Venema, RC
Murphy, LL
Singletary, KW
Young, AJ
AF Jackson, Steven J. T.
Venema, Richard C.
Murphy, Laura L.
Singletary, Keith W.
Young, Andrew J.
TI Curcumin modulates hemeoxygenase-1, eNOS, and endothelial cell cycle
progression
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Jackson, Steven J. T.; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Venema, Richard C.] Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA.
[Murphy, Laura L.] So Illinois Univ, Dept Physiol, Carbondale, IL 62901 USA.
[Singletary, Keith W.] Univ Illinois, Urbana, IL 61801 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675500429
ER
PT J
AU Karl, JP
Lieberman, HR
Cable, SJ
Williams, KW
Young, AJ
McClung, JP
AF Karl, J. Philip
Lieberman, Harris R.
Cable, Sonya J.
Williams, Kelly W.
Young, Andrew J.
McClung, James P.
TI Relationships between iron status, serum hepcidin and inflammation in
female Soldiers during military training
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Karl, J. Philip; Lieberman, Harris R.; Young, Andrew J.; McClung, James P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
[Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675500396
ER
PT J
AU Kenefick, RW
Cheuvront, SN
Ely, BR
Palombo, LJ
Sawka, MN
AF Kenefick, Robert W.
Cheuvront, Samuel N.
Ely, Brett R.
Palombo, Laura J.
Sawka, Michael N.
TI High Skin Temperature Accentuates Aerobic Performance Degradation when
Hypohydrated
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kenefick, Robert W.; Cheuvront, Samuel N.; Ely, Brett R.; Palombo, Laura J.; Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675501115
ER
PT J
AU Kenefick, RW
Ely, BR
Cheuvront, SN
Palombo, LJ
Sawka, MN
AF Kenefick, Robert W.
Ely, Brett R.
Cheuvront, Samuel N.
Palombo, Laura J.
Sawka, Michael N.
TI Effects of Skin Temperature on Hypohydration Mediated Hemodynamic
Responses to Submaximal Exercise.
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kenefick, Robert W.; Ely, Brett R.; Cheuvront, Samuel N.; Palombo, Laura J.; Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675500530
ER
PT J
AU Kirby, S
Norris, J
Cerasoli, D
Bahnson, B
AF Kirby, Stephen
Norris, Joseph
Cerasoli, Douglas
Bahnson, Brian
TI Engineering Platelet-Activating Factor Acetylhydrolase as a Catalytic
Bioscavenger for Organophosphorus Compounds
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Kirby, Stephen; Norris, Joseph; Cerasoli, Douglas] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA.
[Kirby, Stephen; Bahnson, Brian] Univ Delaware, Newark, DE USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675504103
ER
PT J
AU Klemcke, HG
Rose, R
Oh, T
Calderon, ML
AF Klemcke, Harold G.
Rose, Rajiv
Oh, Thomas
Calderon, Mariam L.
TI Survival time after hemorrhage (STaH) in inbred rats with known blood
volumes
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Klemcke, Harold G.; Rose, Rajiv; Oh, Thomas; Calderon, Mariam L.] USA, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675505367
ER
PT J
AU Lieberman, HR
Kellogg, MD
Lesher, LL
Kramer, FM
AF Lieberman, Harris R.
Kellogg, Mark D.
Lesher, Larry L.
Kramer, F. Matthew
TI Improved Overall Mood during Military Basic Combat Training (BCT),
including lower Anxiety, Fatigue and Depression, is associated with
changes in nutritional and metabolic state
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Lieberman, Harris R.; Kellogg, Mark D.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Lesher, Larry L.; Kramer, F. Matthew] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675502877
ER
PT J
AU Lorenzo, S
Sawka, MN
Minson, CT
AF Lorenzo, Santiago
Sawka, Michael N.
Minson, Christopher T.
TI Heat acclimation induces peripheral modifications in cutaneous vascular
function in humans
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Lorenzo, Santiago; Minson, Christopher T.] Univ Oregon, Eugene, OR 97403 USA.
[Sawka, Michael N.] USA, Thermal & Mt Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675500733
ER
PT J
AU Lorenzo, S
Miller, D
Halliwill, JR
Sawka, MN
Minson, CT
AF Lorenzo, Santiago
Miller, Danielle
Halliwill, John R.
Sawka, Michael N.
Minson, Christopher T.
TI Heat acclimation improves central cardiac function and performance
variables in cool environments
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Lorenzo, Santiago; Miller, Danielle; Halliwill, John R.; Minson, Christopher T.] Univ Oregon, Eugene, OR 97403 USA.
[Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675500421
ER
PT J
AU Martens, ME
AF Martens, Margaret E.
TI Mechanisms of Mitochondrial Dysfunction Induced by Sulfur Mustard in
Human Epidermal Keratinocytes (HEK)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Martens, Margaret E.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675505127
ER
PT J
AU Martens, ME
Olivera, DS
AF Martens, Margaret E.
Olivera, Dorian S.
TI Impaired Energy Metabolism in Airway Epithelial Cells Exposed to the
Industrial Toxicant Phosgene
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Martens, Margaret E.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA.
[Olivera, Dorian S.] USA, Med Res Inst Chem Def, Med Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675502685
ER
PT J
AU McClung, JP
Andersen, NE
Wiley, BC
Marchitelli, LJ
Hennigar, SR
Young, AJ
AF McClung, James P.
Andersen, Nancy E.
Wiley, Bryan C.
Marchitelli, Louis J.
Hennigar, Stephen R.
Young, Andrew J.
TI Iron deficiency does not cause obesity in adult rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [McClung, James P.; Andersen, Nancy E.; Wiley, Bryan C.; Marchitelli, Louis J.; Hennigar, Stephen R.; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675500866
ER
PT J
AU McGraw, SM
DeGroot, DW
Ely, MR
Karl, JP
Young, AJ
Lieberman, HR
AF McGraw, Susan M.
DeGroot, David W.
Ely, Matthew R.
Karl, James P.
Young, Andrew J.
Lieberman, Harris R.
TI Effects on mood and satiety of 4 days of partial energy deficit (60%) or
energy excess (150%)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [McGraw, Susan M.; Ely, Matthew R.; Karl, James P.; Young, Andrew J.; Lieberman, Harris R.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
[DeGroot, David W.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675503870
ER
PT J
AU Miller, SA
Muhie, S
Juibitu, M
Moyler, C
Hammamieh, R
Jett, M
AF Miller, Stacy-Ann
Muhie, Seid
Juibitu, Meskerem
Moyler, Candace
Hammamieh, Rasha
Jett, Marti
TI Gene Profiles of Host Biological Processes Targeted by Yersinia pestis
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Miller, Stacy-Ann; Muhie, Seid; Juibitu, Meskerem; Moyler, Candace; Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675502891
ER
PT J
AU Moeckel-Cole, SA
Zambraski, E
Gordish-Dressman, H
Hoffman, E
Devaney, J
Clarkson, P
AF Moeckel-Cole, Stephanie Anne
Zambraski, Edward
Gordish-Dressman, Heather
Hoffman, Eric
Devaney, Joe
Clarkson, Priscilla
TI A Single Nucleotide Polymorphism (SNP) in Titin (TTN) Decreases Muscle
Soreness and Strength Deficits after Eccentric Exercise in Women
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Moeckel-Cole, Stephanie Anne; Clarkson, Priscilla] Univ Massachusetts, Amherst, MA 01003 USA.
[Zambraski, Edward] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Gordish-Dressman, Heather; Hoffman, Eric; Devaney, Joe] Med Genet Res Ctr, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675501328
ER
PT J
AU Mu, TS
Batts, SG
Sato, A
Hernandez, C
Ichimura, W
Lentz-Kapua, SL
Uyehara, CFT
AF Mu, Thornton Samuel
Batts, Sherreen G.
Sato, Aileen
Hernandez, Claudia
Ichimura, Wayne
Lentz-Kapua, Sarah L.
Uyehara, Catherine F. T.
TI Renin-Angiotensin-Aldosterone System During Extracorporeal Membrane
Oxygenation (ECMO) in a Pig Model of Septic Shock
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Mu, Thornton Samuel; Batts, Sherreen G.; Sato, Aileen; Hernandez, Claudia; Ichimura, Wayne; Lentz-Kapua, Sarah L.; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675505109
ER
PT J
AU Muhie, S
Hammamieh, R
Yang, D
Jett, M
AF Muhie, Seid
Hammamieh, Rasha
Yang, David
Jett, Marti
TI Staphylococcus Enterotoxin B induced Host Response Signatures in the
Presence and Absence of Battlefield-like Stress
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Muhie, Seid; Yang, David; Jett, Marti] Georgetown Univ, Washington, DC USA.
[Muhie, Seid; Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675502843
ER
PT J
AU Norris, J
Chung, M
Smith, JR
Kirby, S
AF Norris, Joseph
Chung, Myra
Smith, J. Richard
Kirby, Stephen
TI Engineering Human Paraoxonase-1 Double Mutants to Hydrolyze
Organophosphorus Compounds
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Norris, Joseph; Chung, Myra; Smith, J. Richard; Kirby, Stephen] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675502838
ER
PT J
AU Oh, T
Calderon, ML
Klemcke, HG
AF Oh, Taesung
Calderon, M. L.
Klemcke, H. G.
TI Brain stem heme oxygenase 1 (HO-1) mRNA expression in inbred rat strains
after severe hemorrhage
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Oh, Taesung; Calderon, M. L.; Klemcke, H. G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675506623
ER
PT J
AU Polykratis, IA
Rubal, BJ
Sondeen, JL
DeLorenzo, RA
Dubick, MA
AF Polykratis, Irene Amy
Rubal, Bernard J.
Sondeen, Jill L.
DeLorenzo, Robert A.
Dubick, Michael A.
TI The hypercoagulability of initial intraosseous aspirates
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Polykratis, Irene Amy] Intstitute Surg Res, Damage Control & Resuscitat Program, Ft Sam Houston, TX USA.
[Rubal, Bernard J.; DeLorenzo, Robert A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Sondeen, Jill L.; Dubick, Michael A.] USA, Inst Surg Res, Damage Control & Resuscitat Program, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675502559
ER
PT J
AU Rastogi, A
Yang, J
Wang, XY
Bynum, J
Stavchansky, S
Bowman, PD
AF Rastogi, Ashish
Yang, John
Wang, Xinyu
Bynum, James
Stavchansky, Salomon
Bowman, Phillip D.
TI Induction of Hypoxia Inducible Factor 1 Alpha (HIF1 alpha) by Caffeic
Acid Phenethyl Ester (CAPE) and Caffeic Acid Phenethyl Amide (CAPA) in
Mouse Skin Fibroblasts
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Rastogi, Ashish; Yang, John; Wang, Xinyu; Bynum, James; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX USA.
[Rastogi, Ashish; Yang, John; Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Austin, TX 78712 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675505230
ER
PT J
AU Rose, R
Oh, T
Calderon, M
Klemcke, H
AF Rose, Rajiv
Oh, Taesung
Calderon, Mariam
Klemcke, Harold
TI Inter- and intra-strain variability for survival time after hemorrhage
in inbred rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Rose, Rajiv; Oh, Taesung; Calderon, Mariam; Klemcke, Harold] USA, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675507115
ER
PT J
AU Shih, TM
Skovira, JW
McDonough, JH
AF Shih, Tsung-Ming
Skovira, Jacob W.
McDonough, John H.
TI Specificity of Brain Structures Sensitive to Initiating Nerve
Agent-Induced Seizures
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Shih, Tsung-Ming; Skovira, Jacob W.; McDonough, John H.] USA, Div Res, Med Res Inst Chem Defn, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675506460
ER
PT J
AU Shih, TM
Koenig, JA
Tarzia, KA
Skovira, JW
McDonough, JH
AF Shih, Tsung-Ming
Koenig, Jeffrey A.
Tarzia, Kristin A.
Skovira, Jacob W.
McDonough, John H.
TI Protective Effects of Midazolam and MMB-4 plus Atropine Sulfate in Nerve
Agent Intoxication
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Shih, Tsung-Ming; Koenig, Jeffrey A.; Tarzia, Kristin A.; Skovira, Jacob W.; McDonough, John H.] USA, Div Res, Med Res Inst Chem Defn, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675500102
ER
PT J
AU Siller-Jackson, AJ
Bowman, PD
Wenke, JC
Bynum, JA
Hammamieh, R
AF Siller-Jackson, Arlene J.
Bowman, Phillip D.
Wenke, Joseph C.
Bynum, James A.
Hammamieh, Rasha
TI Temporal Gene Expression Profiling of Bone Repair in a Rat Calvarial
Defect
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Siller-Jackson, Arlene J.; Bowman, Phillip D.; Wenke, Joseph C.; Bynum, James A.] USAISR, Ft Sam Houston, TX USA.
[Hammamieh, Rasha] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675507494
ER
PT J
AU Smith, TJ
Anderson, D
Sikes, A
Margolis, LM
Young, AJ
AF Smith, Tracey J.
Anderson, Danielle
Sikes, Anthony
Margolis, Lee M.
Young, Andrew J.
TI Persistence of Lactobacillus Reuteri DSM17938 in the Human Intestinal
Tract
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Smith, Tracey J.; Margolis, Lee M.; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Anderson, Danielle; Sikes, Anthony] Natick Soldier Res, Combat Feeding Directorate, Ctr Dev & Engn, Natick, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675501718
ER
PT J
AU Srinivasan, S
Miller, SA
Shupp, JW
Crosby, MC
Hammamieh, R
Jett, M
AF Srinivasan, Seshamalini
Miller, Stacy-Ann
Shupp, Jeffrey W.
Crosby, Margaret C.
Hammamieh, Rasha
Jett, Marti
TI Differential Gene Expression of Cutaneous Cells Upon Exposure to
Staphylococcal Enterotoxin B (SEB) Superantigen
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Srinivasan, Seshamalini; Miller, Stacy-Ann; Shupp, Jeffrey W.; Crosby, Margaret C.; Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Shupp, Jeffrey W.] Washington Hosp Ctr, Burn Ctr, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 2
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675504786
ER
PT J
AU Stauss, HM
Liaboe, FO
Leon, LR
Kregel, KC
AF Stauss, Harald M.
Liaboe, Frederick O.
Leon, Lisa R.
Kregel, Kevin C.
TI Effect of exertional vs. passive heat stress on diurnal rhythms of
hemodynamic parameters and parasympathetic modulation of cardiac
function
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Stauss, Harald M.; Liaboe, Frederick O.; Kregel, Kevin C.] Univ Iowa, Iowa City, IA USA.
[Leon, Lisa R.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675503166
ER
PT J
AU Stoltenburg, AA
Kemmer, TM
Gidvani-Diaz, V
Lougee, D
Coello, M
Amador, WE
Lynch, J
Thanapura, P
AF Stoltenburg, Ashley Ann
Kemmer, Teresa M.
Gidvani-Diaz, Vinod
Lougee, Douglas
Coello, Miguel
Amador, Wilmer E.
Lynch, Julia
Thanapura, Pravara
TI Mapping of anemia prevalence among Honduran children ages 6-60 months
using global positioning system data
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Stoltenburg, Ashley Ann; Kemmer, Teresa M.; Thanapura, Pravara] S Dakota State Univ, Brookings, SD 57007 USA.
[Gidvani-Diaz, Vinod; Lougee, Douglas] San Antonio Mil Pediat Ctr, San Antonio, TX USA.
[Coello, Miguel; Amador, Wilmer E.] Joint Task Force Bravo, Soto Cano, Honduras.
[Lynch, Julia] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675505687
ER
PT J
AU Urso, ML
Wang, RB
Zambraski, EJ
Liang, BT
AF Urso, Maria Laina
Wang, Ruibo
Zambraski, Edward J.
Liang, Bruce T.
TI Adenosine A3 Receptor Agonists (A3RA) Induce Favorable Alterations in
the MMP/TIMP Response in Skeletal Muscle Following Traumatic Injury
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Urso, Maria Laina; Zambraski, Edward J.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA.
[Wang, Ruibo; Liang, Bruce T.] Univ Connecticut, Ctr Hlth, Pat & Jim Calhoun Cardiol Ctr, Farmington, CT USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675500853
ER
PT J
AU Uyehara, CFT
Sato, AK
Hernandez, CA
Ichimura, WM
Batts, S
Mu, TS
Andaya, JM
AF Uyehara, Catherine F. T.
Sato, Aileen K.
Hernandez, Claudia A.
Ichimura, Wayne M.
Batts, Sherreen
Mu, Thornton S.
Andaya, January M.
TI Extracorporeal Membrane Oxygenation (ECMO) Does Not Restore Renal
Autoregulation in Endotoxin-Induced Acute Renal Failure
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Uyehara, Catherine F. T.; Sato, Aileen K.; Hernandez, Claudia A.; Ichimura, Wayne M.; Batts, Sherreen; Mu, Thornton S.; Andaya, January M.] Tripler Army Med Ctr, Tripler, HI USA.
[Andaya, January M.] Univ Hawaii, Honolulu, HI 96822 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675506470
ER
PT J
AU Wang, XY
Bynum, J
Stavchansky, S
Dubick, M
Hackman, R
Keen, C
Bowman, P
AF Wang, Xinyu
Bynum, James
Stavchansky, Salomon
Dubick, Michael
Hackman, Robert
Keen, Carl
Bowman, Phillip
TI Cytoprotection of human endothelial cells from oxidative stress by
polyphenols: the role of gene expression versus direct antioxidant
effect
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wang, Xinyu; Bynum, James; Dubick, Michael; Bowman, Phillip] USA, Inst Surg Res, San Antonio, TX USA.
[Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Div Pharmaceut, Austin, TX 78712 USA.
[Hackman, Robert; Keen, Carl] Univ Calif Davis, Davis, CA 95616 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675504360
ER
PT J
AU Wang, XY
Bynum, J
Stavchansky, S
Bowman, P
AF Wang, Xinyu
Bynum, James
Stavchansky, Salomon
Bowman, Phillip
TI Network Analysis of the Cytoprotective Effect of CDDO-IM against Oxidant
Stress in Human Umbilical Vein Endothelial Cells (HUVEC)
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wang, Xinyu; Bynum, James; Bowman, Phillip] USA, Inst Surg Res, San Antonio, TX USA.
[Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Div Pharmaceut, Austin, TX 78712 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675504221
ER
PT J
AU Wu, XW
Xiao, YF
Baer, LA
Chen, YD
Wolf, SE
Walters, TJ
Wade, CE
AF Wu, Xiaowu
Xiao, Yufei
Baer, Lisa A.
Chen, Yidong
Wolf, Steven E.
Walters, Thomas J.
Wade, Charles E.
TI The Gene Profile of the Skeletal Muscle in Response to Burn and Hindlimb
Unloading
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Wu, Xiaowu; Baer, Lisa A.; Wolf, Steven E.; Walters, Thomas J.; Wade, Charles E.] USA, Inst Surg Res, San Antonio, TX USA.
[Wu, Xiaowu; Xiao, Yufei; Chen, Yidong; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675504066
ER
PT J
AU Zindel, K
Wiewel, K
Hammamieh, R
Jett, M
Mendis, C
AF Zindel, Kristin
Wiewel, Kurstin
Hammamieh, Rasha
Jett, Marti
Mendis, Chanaka
TI Effect of SEB induced cell death in DU 145 cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Zindel, Kristin; Wiewel, Kurstin; Mendis, Chanaka] Univ Wisconsin, Dept Chem & Engn Phys, Platteville, WI USA.
[Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2010
VL 24
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V28IW
UT WOS:000208675503210
ER
PT J
AU Henne, MB
Bundorf, MK
AF Henne, Melinda B.
Bundorf, M. Kate
TI The effects of competition on assisted reproductive technology outcomes
SO FERTILITY AND STERILITY
LA English
DT Article
DE Assisted reproductive technology; competition; multiple birth rates;
patient selection
ID IN-VITRO FERTILIZATION; HOSPITAL MARKET-STRUCTURE; MULTIPLE GESTATION;
INSURANCE-COVERAGE; PRACTICE PATTERNS; EMBRYO-TRANSFER; INFERTILITY;
COUPLES; BIRTHS; PREGNANCIES
AB Objective: To evaluate the relationship between competition among fertility clinics and assisted reproductive technology (ART) treatment outcomes, particularly multiple births.
Design: Using clinic-level data from 1995 to 2001, we examined the relationship between competition and clinic-level ART outcomes and practice patterns.
Setting: National database registry.
Patient(s): Clinics performing ART.
Intervention(s): The number of clinics within a 20-mile (32.19-km) radius of a given clinic.
Main Outcome Measure(s): Clinic-level births, singleton births, and multiple births per ART cycle; multiple births per ART birth; average number of embryos transferred per cycle; and the proportion of cycles for women under age 35 years.
Result(s): The number of competing clinics is not strongly associated with ART birth and multiple birth rates. Relative to clinics with no competitors, the rate of multiple births per cycle is lower (-0.03 percentage points) only for clinics with more than 15 competitors. Embryo transfer practices are not statistically significantly associated with the number of competitors. Clinic-level competition is strongly associated with patient mix. The proportion of cycles for patients under 35 years old is 6.4 percentage points lower for clinics with more than 15 competitors than for those with no competitors.
Conclusion(s): Competition among fertility clinics does not appear to increase rates of multiple births from ART by promoting more aggressive embryo transfer decisions. (Fertil Steril(R) 2010;93:1820-30. (C) 2010 by American Society for Reproductive Medicine.)
C1 [Henne, Melinda B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Henne, Melinda B.] Stanford Univ, Sch Med, Ctr Hlth Policy Primary Care & Outcomes Res, Stanford, CA 94305 USA.
[Bundorf, M. Kate] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA.
RP Henne, MB (reprint author), Walter Reed Army Med Hosp, Dept Obstet & Gynecol, 6900 Georgia Ave NW,Bldg 2,Room 2J06, Washington, DC 20307 USA.
EM redbbdoc@aol.com
FU Agency for Healthcare Research and Quality (AHRQ); Institute for
Research on Women and Gender at Stanford University
FX Supported by funding from a National Research Service Award training
grant from the Agency for Healthcare Research and Quality (AHRQ) and the
Iris M. Litt Fund from the Institute for Research on Women and Gender at
Stanford University.
NR 41
TC 9
Z9 10
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD APR
PY 2010
VL 93
IS 6
BP 1820
EP 1830
DI 10.1016/j.fertnstert.2008.02.159
PG 11
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 583LS
UT WOS:000276678100014
PM 18442821
ER
PT J
AU Jumaily, JS
Noordzij, JP
Dukas, AG
Lee, SL
Bernet, VJ
Payne, RJ
McLeod, IK
Hier, MP
Black, MJ
Kerr, PD
Raffaelli, M
Bellantone, R
Lombardi, CP
Dietrich, MS
AF Jumaily, Jeffrey Saad
Noordzij, J. Pieter
Dukas, Alex G.
Lee, Stephanie L.
Bernet, Victor J.
Payne, Richard J.
McLeod, Ian K.
Hier, Michael P.
Black, Martin J.
Kerr, Paul D.
Raffaelli, Marco
Bellantone, Rocco
Lombardi, Celestino P.
Dietrich, Mary S.
TI PREDICTION OF HYPOCALCEMIA AFTER USING 1-TO 6-HOUR POSTOPERATIVE
PARATHYROID HORMONE AND CALCIUM LEVELS: AN ANALYSIS OF POOLED INDIVIDUAL
PATIENT DATA FROM 3 OBSERVATIONAL STUDIES
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
NECK
LA English
DT Article
DE thyroidectomy; hypocalcemia; parathyroid hormone (PTH); postoperative
management; rapid parathyroid hormone assay
ID POST-THYROIDECTOMY HYPOCALCEMIA; POSTTHYROIDECTOMY HYPOCALCEMIA;
SURGERY; ASSAY; HYPOPARATHYROIDISM; MANAGEMENT; DISCHARGE
AB Background. Parathyroid hormone (PTH) levels up to 6 hours postthyroidectomy have been shown to have excellent predictive power in determining hypocalcemia. In this study, we investigate the usefulness of combining calcium and PTH to increase the predictive power.
Methods. Individual patient data were obtained from 3 studies (152 patients) that fulfilled our criteria (using PTH assay within hours postthyroidectomy to predict symptomatic hypocalcemia).
Results. Changes in combined PTH and calcium threshold levels checked 1 to 6 hours after thyroidectomy were excellent in predicting postoperative hypocalcemia. A decrease in PTH of 60%, coupled with a simultaneous decrease in calcium of 10%, 5 to 6 hours postoperatively resulted in a sensitivity and specificity of 100%. However, combined PTH and calcium threshold changes were not significantly better than using PTH threshold changes alone.
Conclusions. Threshold changes in serum calcium and PTH, checked hours after surgery, can be used together to accurately predict whether a patient will become hypocalcemic after thyroidectomy. (C) 2009 Wiley Periodicals, Inc. Head Neck 32: 427-434, 2010
C1 [Jumaily, Jeffrey Saad; Noordzij, J. Pieter; Dukas, Alex G.] Boston Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA 02215 USA.
[Lee, Stephanie L.] Boston Univ, Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA USA.
[Bernet, Victor J.] Walter Reed Army Med Ctr, Dept Endocrinol, Washington, DC 20307 USA.
[Payne, Richard J.] McGill Univ, Jewish Gen Hosp, Dept Otolaryngol Head & Neck Surg, Montreal, PQ H3T 1E2, Canada.
[McLeod, Ian K.] Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20307 USA.
[Hier, Michael P.; Black, Martin J.; Kerr, Paul D.] Univ Manitoba, Dept Otolaryngol, Winnipeg, MB, Canada.
[Raffaelli, Marco; Bellantone, Rocco; Lombardi, Celestino P.] Univ Cattolica Sacro Cuore, Dept Surg, Div Endocrine Surg, Rome, Italy.
[Dietrich, Mary S.] Vanderbilt Univ, Sch Nursing, Nashville, TN 37240 USA.
[Dietrich, Mary S.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
RP Noordzij, JP (reprint author), Boston Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA 02215 USA.
EM noordzij@bu.edu
OI Dukas, Alex/0000-0003-1300-4038
NR 34
TC 19
Z9 19
U1 0
U2 4
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1043-3074
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD APR
PY 2010
VL 32
IS 4
BP 427
EP 434
DI 10.1002/hed.21199
PG 8
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA 576HV
UT WOS:000276136000002
PM 19780054
ER
PT J
AU Labrie, JE
Keiser, PB
AF Labrie, Joseph E., III
Keiser, Paul B.
TI Whole cell vaccination for meningococcus Lessons from an idea for which
time has gone
SO HUMAN VACCINES
LA English
DT Editorial Material
DE Neisseria meningitidis; endotoxin; vaccine; outer membrane vesicle;
lipopolysaccharide
ID PROPHYLACTIC VACCINATION; EPIDEMIC MENINGITIS
C1 [Labrie, Joseph E., III; Keiser, Paul B.] Walter Reed Army Inst Res, Dept Meningococcal Vaccines, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
RP Keiser, PB (reprint author), Walter Reed Army Inst Res, Dept Meningococcal Vaccines, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
EM paul.keiser@us.army.mil
NR 46
TC 3
Z9 3
U1 0
U2 0
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1002 WEST AVENUE, 2ND FLOOR, AUSTIN, TX 78701 USA
SN 1554-8600
J9 HUM VACCINES
JI Hum. Vaccines
PD APR
PY 2010
VL 6
IS 4
BP 360
EP 365
PG 6
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA 652GH
UT WOS:000281990800015
PM 20372072
ER
PT J
AU Ehasz, EJ
Goyette, TM
Giles, RH
Nixon, WE
AF Ehasz, Elizabeth J.
Goyette, Thomas M.
Giles, Robert H.
Nixon, William E.
TI High-Resolution Frequency Measurements of Far-Infrared Laser Lines
SO IEEE JOURNAL OF QUANTUM ELECTRONICS
LA English
DT Article
DE Far-infrared (FIR) laser; gas laser; molecular laser; submillimeter-wave
laser; terahertz source
AB The frequency of four previously reported far-infrared laser lines have been measured to an accuracy of 100 kHz. These laser lines were measured using a heterodyne system which allowed for more accurate measurement. The four far-infrared laser lines which originated from Formic Acid (HCOOH), O-Deutero-Formic Acid (HCOOD), C-Deutero-Formic Acid (DCOOH), and Methyl Chloride (CH(3)Cl) were optically pumped by a highly stable, grating-tunable, CO(2) laser. Three of the far-infrared laser lines have been measured previously using Fabry-Perot cavities not typicaly known for their high accuracy. The fourth far-infrared laser line had been measured previously by heterodyne methods but under nonoptimal conditions. The difference between the frequencies measured here and the listed frequencies for these laser lines ranged from 0.9 MHz to 3.9 GHz.
C1 [Ehasz, Elizabeth J.; Goyette, Thomas M.; Giles, Robert H.] Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA.
[Nixon, William E.] USA, Natl Ground Intelligence Ctr, Charlottesville, VA 22911 USA.
RP Ehasz, EJ (reprint author), Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA.
EM elizabeth_ehasz@student.uml.edu
NR 14
TC 2
Z9 2
U1 1
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9197
J9 IEEE J QUANTUM ELECT
JI IEEE J. Quantum Electron.
PD APR
PY 2010
VL 46
IS 4
BP 474
EP 477
DI 10.1109/JQE.2009.2036378
PG 4
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA 558GW
UT WOS:000274730100007
ER
PT J
AU Cheng, SF
Tom, K
Thomas, L
Pecht, M
AF Cheng, Shunfeng
Tom, Kwok
Thomas, Larry
Pecht, Michael
TI A Wireless Sensor System for Prognostics and Health Management
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Cross-validation; prognostics and health management (PHM); radio
frequency identification (RFID); sequential probability ratio test
(SPRT); wireless sensor system
ID ELECTRONICS
AB This paper introduces a novel radio-frequency-based wireless sensor system and describes its prognostics and health management functions. The wireless sensor system includes a radio frequency identification sensor tag, a wireless reader, and diagnostic-prognostic software. The software uses the sequential probability ratio test with a cross-validation procedure to detect anomalies, assess degradation, and predict failures. The prognostic performance of the sensor system is demonstrated by a field application.
C1 [Cheng, Shunfeng] Univ Maryland, CALCE, Prognost & Hlth Management Lab, College Pk, MD 20742 USA.
[Tom, Kwok] USA, Res Lab, Adelphi, MD 20783 USA.
[Thomas, Larry] EPrognost Syst LLC, Leander, TX 78641 USA.
[Pecht, Michael] City Univ Hong Kong, Prognost & Hlth Management Ctr, Hong Kong, Hong Kong, Peoples R China.
RP Cheng, SF (reprint author), Univ Maryland, CALCE, Prognost & Hlth Management Lab, College Pk, MD 20742 USA.
EM chengsf@calce.umd.edu; kwok.tom@us.army.mil; Larry@eProgSys.com;
pecht@calce.umd.edu
OI Pecht, Michael/0000-0003-1126-8662
FU CALCE; Army Research Laboratory; United States Army
FX We thank ePrognostic Systems LLC for providing the data and CALCE's
sponsors, the Army Research Laboratory, and the United States Army
SWORDS project, for providing us guidance and a platform for testing.
NR 13
TC 31
Z9 37
U1 2
U2 28
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD APR
PY 2010
VL 10
IS 4
BP 856
EP 862
DI 10.1109/JSEN.2009.2035817
PG 7
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 566LL
UT WOS:000275371700012
ER
PT J
AU Liao, DH
Sarabandi, K
AF Liao, DaHan
Sarabandi, Kamal
TI On the Effective Low-Grazing Reflection Coefficient of Random Terrain
Roughness for Modeling Near-Earth Radiowave Propagation
SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
LA English
DT Article
DE Monte Carlo simulations; near-earth radiowave propagation; rough
surfaces; volumetric perturbation method
ID WAVE-PROPAGATION; SURFACE
AB An investigation on the effects of terrain roughness on near-ground radiowave propagation is featured. In spite of the fact that a variety of analytical and numerical routines have been proposed by many workers for the general treatment of the scattering properties of rough surfaces, much disagreement remains in the solution of the problem for near-grazing scenarios. In striving to analytically describe the near-grazing propagation of signals from 2D and 3D radiators, an existing volumetric polarization current-based perturbation approach is exploited in this work to formulate closed-form expressions for the coherent rough surface reflection coefficients. Although the perturbation approach was originally intended for analyzing the scattering coefficients of a ground with scale of roughness much smaller than the wavelength, it is shown through Monte Carlo simulations that the effective reflection coefficients reported herein are applicable for near-ground path-loss prediction even when the surface variation (height) is on the order of a wavelength or more.
C1 [Liao, DaHan; Sarabandi, Kamal] Univ Michigan, Radiat Lab, Ann Arbor, MI 48109 USA.
RP Liao, DH (reprint author), USA, Res Lab, Adelphi, MD USA.
EM liaod@umich.edu; saraband@eecs.umich.edu
NR 19
TC 4
Z9 4
U1 0
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-926X
J9 IEEE T ANTENN PROPAG
JI IEEE Trans. Antennas Propag.
PD APR
PY 2010
VL 58
IS 4
BP 1315
EP 1324
DI 10.1109/TAP.2010.2041310
PG 10
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 579YX
UT WOS:000276414500032
ER
PT J
AU Wijewarnasuriya, PS
Chen, YP
Brill, G
Zandi, B
Dhar, NK
AF Wijewarnasuriya, Priyalal S.
Chen, Yuanping
Brill, Gregory
Zandi, Bahram
Dhar, Nibir K.
TI High-Performance Long-Wavelength Infrared HgCdTe Focal Plane Arrays
Fabricated on CdSeTe Compliant Si Substrates
SO IEEE TRANSACTIONS ON ELECTRON DEVICES
LA English
DT Article
DE CdSeTe; CdTe; compliant Si substrates; focal plane arrays (FPAs);
HgCdTe; infrared (IR) detectors; long-wavelength IR; molecular beam
epitaxy (MBE)
ID MOLECULAR-BEAM EPITAXY; HG1-XCDXTE PHOTOVOLTAIC DETECTORS;
REMOTE-SENSING APPLICATIONS; GROWTH; PHOTODIODES; CDZNTE/SI; QUALITY;
DEFECTS; SI(211)
AB At the U.S. Army Research Laboratory, a new ternary semiconductor system CdSe(x)Te(1-x)/Si(211) is being investigated as an alternative substrate to bulk-grown CdZnTe substrates for HgCdTe growth by molecular beam epitaxy. Long-wavelength (LW) photovoltaic devices fabricated on this compliant substrate material show diffusion limited performance at 78 K, indicating a high-quality material. The measured R(o)A at 78 K on lambda(co) = 10 mu m material is on the order of 340 Omega . cm(2). In addition to single devices, we have fabricated 256 x 256 2-D arrays with a 40-mu m pixel pitch on LW-HgCdTe grown on CdSe(x)Te(1-x)/Si(211) compliant substrates. The data show an excellent quantum efficiency operability of 99% at 78 K under a tactical background flux of 6.7 x 10(15) ph/cm(2)s. The most probable dark current at peak distribution is 5.5 x 10(9) e-/s and is very consistent with the measured R(o)A values from single devices. This work demonstrates that CdSe(x)Te(1-x)/Si(211) substrates provide a potential roadmap for more affordable robust third-generation focal plane arrays.
C1 [Wijewarnasuriya, Priyalal S.; Chen, Yuanping; Brill, Gregory; Zandi, Bahram; Dhar, Nibir K.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Wijewarnasuriya, PS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM priyalal.wijewarnasuriya@us.army.mil
FU U.S. Department of Commerce [BS123456]; Dr. M. Tidrow of the Missile
Defense Agency
FX This work was supported in part by the U.S. Department of Commerce under
Grant BS123456 and in part by Dr. M. Tidrow of the Missile Defense
Agency. The review of this paper was arranged by Editor J. Tower.
NR 19
TC 10
Z9 10
U1 0
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9383
J9 IEEE T ELECTRON DEV
JI IEEE Trans. Electron Devices
PD APR
PY 2010
VL 57
IS 4
BP 782
EP 787
DI 10.1109/TED.2010.2041511
PG 6
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA 574OB
UT WOS:000275998500007
ER
PT J
AU Elliott, LR
van Erp, JBF
Redden, ES
Duistermaat, M
AF Elliott, Linda R.
van Erp, Jan B. F.
Redden, Elizabeth S.
Duistermaat, Maaike
TI Field-Based Validation of a Tactile Navigation Device
SO IEEE TRANSACTIONS ON HAPTICS
LA English
DT Article
DE Psychology; social and behavioral sciences; computer applications;
design for wearability; user interfaces; information interfaces and
representation (HCI); information technology and systems; military;
computers in other systems; haptic I/O
ID VIBROTACTILE; PERFORMANCE; DISPLAYS; SIGNALS; DESIGN; TORSO
AB In this paper, we present three field-based evaluations of a tactile land navigation system. In Experiment 1, we transition from a laboratory setting to rugged terrain used to train US Army soldier land navigation. Navigation in this challenging terrain requires careful attention to one's surroundings. Participants navigated 3 waypoints along 600 meters through heavily wooded terrain, using 1) map and compass, 2) standard alpha-numeric handheld GPS device, and 3) the tactile GPS system, while also responding to radio requests for information. Experiment 2 used the same challenging terrain during night operations, where participants must also search for live and silhouette targets, using 1) handheld GPS device, 2) head-mounted map-based GPS, and 3) the tactile GPS system. In addition to navigating, participants searched for silhouette and live (human) targets. Experiment 3 had participants navigate with 1) a commercial GPS arrow display, 2) the tactile GPS system, and 3) both together. We conclude that tactile navigation displays can be used in strenuous outdoor environments and can outperform visual displays under conditions of high cognitive and visual workload.
C1 [Elliott, Linda R.; Redden, Elizabeth S.] USA, Army Res Lab Field Element, Infantry Ctr, Ft Benning, GA 31905 USA.
[van Erp, Jan B. F.; Duistermaat, Maaike] TNO Human Factors, NL-3769 ZG Soesterberg, Netherlands.
RP Elliott, LR (reprint author), USA, Army Res Lab Field Element, Infantry Ctr, Bldg 4, Ft Benning, GA 31905 USA.
EM Linda.r.elliott@us.army.mil; jan.vanerp@tno.nl;
elizabeth.redden@us.army.mil; maaike.duistermaat@tno.nl
OI van Erp, Jan/0000-0002-6511-2850
FU US Army
FX This work was supported by an Advanced Technology Objective for enhanced
situational understanding for dismount infantry soldiers of the US Army.
The views, opinions, and/or findings contained in this paper are those
of the authors and should not be construed as an official Department of
the Army position, policy, or decision unless so designated by other
documentation.
NR 49
TC 22
Z9 22
U1 1
U2 4
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1939-1412
EI 2329-4051
J9 IEEE T HAPTICS
JI IEEE Trans. Haptics
PD APR-JUN
PY 2010
VL 3
IS 2
BP 78
EP 87
DI 10.1109/ToH.2010.3
PG 10
WC Computer Science, Cybernetics
SC Computer Science
GA 749MB
UT WOS:000289470300002
PM 27788115
ER
PT J
AU Tribble, DR
Baqar, S
Scott, DA
Oplinger, ML
Trespalacios, F
Rollins, D
Walker, RI
Clements, JD
Walz, S
Gibbs, P
Burg, EF
Moran, AP
Applebee, L
Bourgeois, AL
AF Tribble, David R.
Baqar, Shahida
Scott, Daniel A.
Oplinger, Michael L.
Trespalacios, Fernando
Rollins, David
Walker, Richard I.
Clements, John D.
Walz, Steven
Gibbs, Paul
Burg, Edward F., III
Moran, Anthony P.
Applebee, Lisa
Bourgeois, A. Louis
TI Assessment of the Duration of Protection in Campylobacter jejuni
Experimental Infection in Humans
SO INFECTION AND IMMUNITY
LA English
DT Article
ID GUILLAIN-BARRE-SYNDROME; CLINICAL-FEATURES; IMMUNE-RESPONSE; DENDRITIC
CELLS; PHASE VARIATION; RAW-MILK; IN-VIVO; CHILDREN; THAILAND;
LIPOOLIGOSACCHARIDE
AB A human Campylobacter jejuni infection model provided controlled exposure to assess vaccine efficacy and investigate protective immunity for this important diarrheal pathogen. A well-characterized outbreak strain, C. jejuni 81-176, was investigated using a volunteer experimental infection model to evaluate the dose range and duration of protection. Healthy Campylobacter-seronegative adults received C. jejuni strain 81-176 via oral inoculation of 10(5), 10(7), or 10(9) CFU (5 adults/dose), which was followed by clinical and immunological monitoring. Based on dose range clinical outcomes, the 10(9)-CFU dose (n = 31) was used to assess homologous protection at 28 to 49 days (short-term veterans [STV]; n = 8) or 1 year (long-term veterans [LTV]; n = 7) after primary infection. An illness dose effect was observed for naive subjects (with lower doses, 40 to 60% of the subjects were ill; with the 10(9)-CFU dose, 92% of the subjects were ill) along with complete protection for the STV group and attenuated illness for the LTV group (57%). Partial resistance to colonization was seen in STV (25% of the subjects were not infected; 3-log-lower maximum excretion level). Systemic and mucosal immune responses were robust in naive subjects irrespective of the dose or the severity of illness. In contrast, in STV there was a lack of circulating antibody-secreting cells (ASC), reflecting the local mucosal effector responses. LTV exhibited comparable ASC responses to primary infection, and anamnestic fecal IgA responses likely contributed to self-resolving illness prior to antibiotic treatment. Campylobacter antigen-dependent production of gamma interferon by peripheral blood mononuclear cells was strongly associated with protection from illness, supporting the hypothesis that TH1 polarization has a primary role in acquired immunity to C. jejuni. This study revealed a C. jejuni dose-related increase in campylobacteriosis rates, evidence of complete short-term protection that waned with time, and immune response patterns associated with protection.
C1 [Tribble, David R.; Baqar, Shahida; Scott, Daniel A.; Rollins, David; Walz, Steven; Burg, Edward F., III; Applebee, Lisa; Bourgeois, A. Louis] USN, Med Res Ctr, Silver Spring, MD USA.
[Oplinger, Michael L.; Trespalacios, Fernando; Gibbs, Paul] USA, Med Res Inst Infect Dis, Frederick, MD USA.
[Clements, John D.] Tulane Univ, Sch Med, New Orleans, LA 70112 USA.
[Walker, Richard I.] Antex Biol, Gaithersburg, MD USA.
[Moran, Anthony P.] Natl Univ Ireland, Galway, Ireland.
RP Tribble, DR (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM dtribble@usuhs.mil
FU [643807A.849.D.A0002]
FX This work was supported by Work Unit no. 643807A.849.D.A0002.
NR 55
TC 28
Z9 28
U1 0
U2 10
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD APR
PY 2010
VL 78
IS 4
BP 1750
EP 1759
DI 10.1128/IAI.01021-09
PG 10
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 570FA
UT WOS:000275656400034
PM 20086085
ER
PT J
AU Weintrob, AC
Roediger, MP
Barber, M
Summers, A
Fieberg, AM
Dunn, J
Seldon, V
Leach, F
Huang, XZ
Nikolich, MP
Wortmann, GW
AF Weintrob, Amy C.
Roediger, Mollie P.
Barber, Melissa
Summers, Amy
Fieberg, Ann M.
Dunn, James
Seldon, Venus
Leach, Fluryanne
Huang, Xiao-Zhe
Nikolich, Mikeljon P.
Wortmann, Glenn W.
TI Natural History of Colonization with Gram-Negative Multidrug-Resistant
Organisms among Hospitalized Patients
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
ID TERM-CARE FACILITY; MULTIRESISTANT ACINETOBACTER-BAUMANNII;
STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA;
CALCOACETICUS COMPLEX; DIGESTIVE-TRACT; CANCER-PATIENTS; RISK-FACTORS;
ICU PATIENTS
AB OBJECTIVE. To determine the anatomic sites and natural history of colonization with gram-negative multidrug-resistant organisms (MDROs).
DESIGN. Prospective, longitudinal cohort study.
SETTING. Walter Reed Army Medical Center, a 236-bed tertiary care center in Washington, DC.
PATIENTS. Deployed subjects (ie, inpatients medically evacuated from Iraq or Afghanistan) or nondeployed subjects admitted to the same hospital.
METHODS. Consenting patients had 6 anatomic sites cultured every 3 days for 2 weeks and then weekly. Gram-negative organisms resistant to 3 or more classes of antibiotics were considered MDROs. Isolates were genotyped using pulsed-field gel electrophoresis. Clinical data, data on antibiotic use, and clinical culture results were collected.
RESULTS. Of 60 deployed subjects, 14 (23%) were colonized with an MDRO at admission, and 13 (22%) had incident colonization during hospitalization. The groin was the most sensitive anatomic site for detecting MDRO colonization, and all but one subject remained colonized for the duration of their hospitalization. Sixty percent of subjects with incident Acinetobacter colonization and 25% of subjects with incident Klebsiella colonization had strains that were related to those isolated from other subjects. Of 60 nondeployed subjects, 5 (8%) were colonized with an MDRO at admission; all had recent healthcare contact, and 1 nondeployed subject had an isolate related to a strain recovered from a deployed subject.
CONCLUSIONS. Colonization with gram-negative MDROs is common among patients with war-related trauma admitted to a military hospital and also occurs among nondeployed patients with recent healthcare contact. The groin is the most sensitive anatomic site for active surveillance, and spontaneous decolonization is rare.
C1 [Weintrob, Amy C.; Barber, Melissa] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Huang, Xiao-Zhe; Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Weintrob, Amy C.; Dunn, James; Seldon, Venus; Leach, Fluryanne; Wortmann, Glenn W.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA.
[Summers, Amy] Walter Reed Army Med Ctr, Microbiol Serv, Washington, DC 20307 USA.
[Roediger, Mollie P.; Fieberg, Ann M.] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
RP Weintrob, AC (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, 6900 Georgia Ave,NW,Bldg 2,Ward 63,Room 6312, Washington, DC 20307 USA.
EM Amy.Weintrob@us.army.mil
FU NIAID NIH HHS [Y1-AI-5072]
NR 35
TC 37
Z9 40
U1 2
U2 6
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD APR
PY 2010
VL 31
IS 4
BP 330
EP 337
DI 10.1086/651304
PG 8
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 562DW
UT WOS:000275030600003
PM 20175687
ER
PT J
AU Aldous, WK
Co, EMA
AF Aldous, Wade K.
Co, Edgie-Mark A.
TI Factors Associated with Recovery of Multidrug-Resistant Bacteria in a
Combat Support Hospital in Iraq
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Editorial Material
C1 [Aldous, Wade K.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA.
[Aldous, Wade K.; Co, Edgie-Mark A.] Ibn Sina Hosp, Combat Support Hosp 10, Lab Serv, Baghdad, Iraq.
[Co, Edgie-Mark A.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
RP Aldous, WK (reprint author), Brooke Army Med Ctr, Dept Pathol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM wade.aldous@us.army.mil
RI Co, Edgie-Mark/A-9142-2011
NR 8
TC 2
Z9 2
U1 0
U2 0
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD APR
PY 2010
VL 31
IS 4
BP 425
EP 427
DI 10.1086/651302
PG 3
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 562DW
UT WOS:000275030600019
PM 20184421
ER
PT J
AU Levin, AO
Carpenter, KM
Fowler, JM
Brothers, BM
Andersen, BL
Maxwell, GL
AF Levin, Anna O.
Carpenter, Kristen M.
Fowler, Jeffrey M.
Brothers, Brittany M.
Andersen, Barbara L.
Maxwell, G. Larry
TI Sexual Morbidity Associated With Poorer Psychological Adjustment Among
Gynecological Cancer Survivors
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
LA English
DT Article
DE Sexual morbidity; Gynecological cancers; Survivorship; Quality of life;
Psychological adjustment
ID LONG-TERM ADJUSTMENT; EARLY-STAGE BREAST; QUALITY-OF-LIFE; SCALE CES-D;
CERVICAL-CANCER; OVARIAN-CANCER; PSYCHOEDUCATIONAL INTERVENTION;
ONCOLOGY-GROUP; EVENT SCALE; WOMEN
AB Objectives: Sexual morbidity is a distressing and undertreated problem in gynecological cancer survivorship known to occur early and persist well beyond the period of physical recovery. Although often studied as a separate domain, sexuality represents an integral component of psychological adjustment and quality of life (QoL) that is adversely affected by cancer treatments. The present study tests the association between sexual morbidity, and adverse psychological adjustment and QoL outcomes.
Methods: A cross-sectional design was used. The participants were gynecological (cervical, endometrial, ovarian, and vulvar) cancer survivors who were partnered (N = 186), whose cancer was diagnosed 2 to 10 years previously, and who were at least 6 months post any cancer therapy. Most had been found to have early-stage disease (70%) and were treated with hysterectomy (77%), chemotherapy (43%), and/or radiotherapy (23%). Sexual morbidity was operationalized as a multidimensional construct including sexual behavior, sexual functioning, and subjective sexual satisfaction, assessed by patient self-report. Outcomes included self-reported depressive symptoms, traumatic stress symptoms, cancer-specific stress, stress about body changes, and QoL. Nurse-rated of performance status and disruptive signs/symptoms of treatment toxicity, as well as relevant sociodemographic and disease variables were collected as potential controls.
Results: Hierarchical multiple regression analyses tested sexual morbidity as a predictor of poor outcomes. All statistical models were significant, accounting for 12% to 53% of the variance in psychological adjustment/QoL. Sexual morbidity covaried with worsened depressive symptoms, body change stress, and psychological QoL beyond the negative contributions of (older) age, (poorer) performance status, and (greater) fatigue. Notably, disease and treatment variables were not statistically significant correlates of psychological adjustment or QoL.
Conclusions: These findings suggest that prevention or treatment of sexual morbidity might foster improved psychological adjustment/ QoL. Given the high rates of sexual morbidity in this population and the connection between sexuality and broader psychological adjustment/ QoL, there is a clear need for better integration of sexuality rehabilitation into routine clinical care.
C1 [Levin, Anna O.; Carpenter, Kristen M.; Andersen, Barbara L.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
[Fowler, Jeffrey M.] Ohio State Univ, Dept Obstet & Gynecol, Columbus, OH 43210 USA.
[Fowler, Jeffrey M.; Brothers, Brittany M.; Andersen, Barbara L.] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA.
[Maxwell, G. Larry] Walter Reed Army Med Ctr, Gynecol Dis Ctr, US Mil Canc Inst, Washington, DC 20307 USA.
RP Carpenter, KM (reprint author), Ohio State Univ, Dept Psychol, Psychol Bldg 159,1885 Neil Ave, Columbus, OH 43210 USA.
EM carpenter.292@osu.edu
RI Carpenter, Kristen/I-1569-2013
FU Henry M. Jackson Foundation for Military Medicine [DODGCC-2004-1];
National Cancer Institute [R01CA92704, K05CA098133]; Graduate School of
The Ohio State University
FX This study was supported by the Henry M. Jackson Foundation for Military
Medicine (DODGCC-2004-1), the National Cancer Institute (R01CA92704 and
K05CA098133), and the Graduate School of The Ohio State University.
NR 43
TC 30
Z9 30
U1 3
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1048-891X
J9 INT J GYNECOL CANCER
JI Int. J. Gynecol. Cancer
PD APR
PY 2010
VL 20
IS 3
BP 461
EP 470
DI 10.1111/IGC.0b013e3181d24ce0
PG 10
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 586IJ
UT WOS:000276899900025
PM 20375814
ER
PT J
AU Shaffer, DN
Ngetich, IK
Bautista, CT
Sawe, FK
Renzullo, PO
Scott, PT
Kibaya, RM
Imbuki, KO
Michael, NL
Birx, DL
Wasunna, MK
Robb, ML
AF Shaffer, Douglas N.
Ngetich, Ignatius K.
Bautista, Christian T.
Sawe, Frederick K.
Renzullo, Philip O.
Scott, Paul T.
Kibaya, Rukia M.
Imbuki, Kennedy O.
Michael, Nelson L.
Birx, Deborah L.
Wasunna, Monique K.
Robb, Merlin L.
TI HIV-1 Incidence Rates and Risk Factors in Agricultural Workers and
Dependents in Rural Kenya: 36-Month Follow-Up of the Kericho HIV Cohort
Study
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE HIV; incidence; cohort; Kericho; Kenya
ID REPRODUCTIVE AGE; KAGERA REGION; INFECTION; UGANDA; POPULATION;
PREVALENCE; TRENDS; MALAWI; PROSTITUTES; TANZANIA
AB Background: Incidence data from prospective cohort studies using rigorous laboratory methods are important in designing and evaluating HIV vaccine and therapeutic clinical trials and health care programs. We report 36-month HIV-1 incidence rates and demographic and psychosocial risks from the Kericho cohort in rural Kenya's southern Rift Valley Province.
Methods: Thirty-six month, prospective, closed, observational cohort study of adult plantation workers and dependents followed biannually. HIV-1 incidence rates per 100 person-years (py) were calculated, and Cox regression analyses were used to estimate hazards ratios (HR) associated with seroconversion.
Results: Two thousand four hundred volunteers (mean age +/- SD = 30.1 +/- 8.5 years; 36.5% women) participated. Twenty-nine new HIV cases were identified in year 1 of follow-up, which increased to cumulative totals of 49 and 63 cases in years 2 and 3, respectively. The corresponding 1-, 2-, and 3-year incidence rates were 1.41 [95% confidence interval (CI) = 0.95-2.02], 1.16 (95% CI = 0.86-1.54), and 1.00 (95% CI = 0.77-1.28) per 100 py. Risk factors associated with HIV seroconversion included the following: of the Luo tribe (HR = 3.31; 95% CI = 1.65-6.63), marriage more than once (HR = 2.83; 95% CI = 1.20-6.69), self-reported male circumcision (HR = 0.32; 95% CI = 0.17-0.60), history of sexually transmitted infection (HR = 2.40; 95% CI = 1.09-5.26), history of substance abuse during sex (HR = 2.44; 95% CI = 1.16-5.13), and history of transactional sex (HR = 3.30; 95% CI = 1.79-6.09).
Conclusions: HIV-1 incidence rates were relatively low in adult plantation workers and dependents in rural Kenya. Cohorts including higher risk populations (eg, commercial sex workers) warrant consideration for regional HIV preventive vaccine trials. Even low incidence, well-described cohorts generate valuable epidemiological clinical trial data.
C1 [Shaffer, Douglas N.; Ngetich, Ignatius K.; Bautista, Christian T.; Sawe, Frederick K.; Scott, Paul T.; Kibaya, Rukia M.; Imbuki, Kennedy O.; Michael, Nelson L.; Birx, Deborah L.; Robb, Merlin L.] US Mil HIV Res Program, Rockville, MD USA.
[Shaffer, Douglas N.] Kenya Walter Reed Project HIV Program, US Army Med Res Unit, Kericho, Kenya.
[Shaffer, Douglas N.; Scott, Paul T.; Michael, Nelson L.; Birx, Deborah L.] Walter Reed Army Inst Res, Rockville, MD USA.
[Ngetich, Ignatius K.; Sawe, Frederick K.; Kibaya, Rukia M.; Imbuki, Kennedy O.; Wasunna, Monique K.] Kenya Govt Med Res Ctr, Kericho, Kenya.
[Ngetich, Ignatius K.; Sawe, Frederick K.; Kibaya, Rukia M.; Imbuki, Kennedy O.; Wasunna, Monique K.] Kenya Govt Med Res Ctr, Nairobi, Kenya.
[Bautista, Christian T.] Adv Mil Med Inc, Henry M Jackson Fdn, Rockville, MD USA.
[Renzullo, Philip O.; Robb, Merlin L.] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA.
RP Shaffer, DN (reprint author), Kenya Walter Reed Project HIV Program, US Army Med Res Unit, Kericho, Kenya.
EM dshaffer@wrp-kch.org
RI Bautista, Christian/B-2812-2011
FU Walter Reed Army Institute of Research Institutional Research Board
[RV142]; HIV and Malaria Cohort Study Among Plantation Workers and Adult
Dependents in Kericho, Kenya, is funded through the United States
Military HIV Research Program
FX Supported by The Walter Reed Army Institute of Research Institutional
Research Board human use protocol #855 (RV142); "HIV and Malaria Cohort
Study Among Plantation Workers and Adult Dependents in Kericho, Kenya,"
is funded through the United States Military HIV Research Program (the
Walter Reed Army Institute of Research and the Henry M. Jackson
Foundation for the Advancement of Military Medicine Inc).
NR 24
TC 5
Z9 5
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 1
PY 2010
VL 53
IS 4
BP 514
EP 521
DI 10.1097/QAI.0b013e3181bcdae0
PG 8
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 567YW
UT WOS:000275486600013
PM 19855286
ER
PT J
AU Collamer, A
Arroyo, R
AF Collamer, Angelique
Arroyo, Ramon
TI Bone Marrow Hemophagocytosis Complicating Rheumatoid Arthritis
SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
LA English
DT Article
C1 [Collamer, Angelique; Arroyo, Ramon] Brooke Army Med Ctr, Rheumatol Serv, Ft Sam Houston, TX 78234 USA.
RP Collamer, A (reprint author), Brooke Army Med Ctr, Rheumatol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM angelique.collamer@amedd.army.mil
NR 2
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-1608
J9 JCR-J CLIN RHEUMATOL
JI JCR-J. Clin. Rheumatol.
PD APR
PY 2010
VL 16
IS 3
BP 151
EP 151
DI 10.1097/RHU.0b013e3181d569e1
PG 1
WC Rheumatology
SC Rheumatology
GA 584CB
UT WOS:000276726500015
PM 20375826
ER
PT J
AU Ashar, R
Lewis, S
Blazes, DL
Chretien, JP
AF Ashar, Raj
Lewis, Sheri
Blazes, David L.
Chretien, J. P.
TI Applying information and communications technologies to collect health
data from remote settings: A systematic assessment of current
technologies
SO JOURNAL OF BIOMEDICAL INFORMATICS
LA English
DT Article
DE Public health; Disease surveillance; Health surveillance; Developing
nations; Data collection; Communications networks; Telecommunications;
Mobile technologies
ID DISEASE SURVEILLANCE
AB Modern information and communications technologies (ICTs) are now so feature-rich and widely available that they can be used to "capture," or collect and transmit, health data from remote settings. Electronic data capture can reduce the time necessary to notify public health authorities, and provide important baseline information. A number of electronic health data capture systems based on specific ICTs have been developed for remote areas. We expand on that body of work by defining and applying an assessment process to characterize ICTs for remote-area health data capture. The process is based on technical criteria, and assesses the feasibility and effectiveness of specific technologies according to the resources and constraints of a given setting. Our characterization of current ICTs compares different system architectures for remote-area health data capture systems. Ultimately, we believe that our criteria-based assessment process will remain useful for characterizing future ICTs. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Ashar, Raj; Lewis, Sheri] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.
[Blazes, David L.] Armed Forces Hlth Surveillance Ctr, Div GEIS Operat, Silver Spring, MD USA.
[Chretien, J. P.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA.
RP Ashar, R (reprint author), Johns Hopkins Univ, Appl Phys Lab, 11100 Johns Hopkins Rd, Laurel, MD 20723 USA.
EM Raj.Ashar@jhuapl.edu
NR 46
TC 6
Z9 6
U1 0
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1532-0464
J9 J BIOMED INFORM
JI J. Biomed. Inform.
PD APR
PY 2010
VL 43
IS 2
BP 332
EP 341
DI 10.1016/j.jbi.2009.11.009
PG 10
WC Computer Science, Interdisciplinary Applications; Medical Informatics
SC Computer Science; Medical Informatics
GA 574SG
UT WOS:000276012800017
PM 19961957
ER
PT J
AU Akers, KS
Chaney, C
Barsoumian, A
Beckius, M
Zera, W
Yu, X
Guymon, C
Keen, EF
Robinson, BJ
Mende, K
Murray, CK
AF Akers, Kevin S.
Chaney, Chris
Barsoumian, Alice
Beckius, Miriam
Zera, Wendy
Yu, Xin
Guymon, Charles
Keen, Edward F., III
Robinson, Brian J.
Mende, Katrin
Murray, Clinton K.
TI Aminoglycoside Resistance and Susceptibility Testing Errors in
Acinetobacter baumannii-calcoaceticus Complex
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID GRAM-NEGATIVE BACILLI; INFECTIOUS-DISEASES SOCIETY; VITEK-2 SYSTEM;
IDENTIFICATION; ANTIBIOTICS; MECHANISMS; GUIDELINES; COLISTIN; AMERICA;
ENZYMES
AB Antimicrobial resistance is depleting the pharmacopeia of agents clinically useful against Gram-negative bacilli. As the number of active agents diminishes, accurate susceptibility testing becomes critical. We studied the susceptibilities of 107 isolates of the Acinetobacter baumannii-calcoaceticus complex to amikacin, gentamicin, and tobramycin using disk diffusion, Etest, as well as the Phoenix, Vitek 2, and MicroScan automated systems, and compared the results to those obtained by broth microdilution. Genes encoding aminoglycoside-modifying enzymes (AMEs) were detected by multiplex PCR, and clonal relationships were determined by pulsed-field gel electrophoresis. Tobramycin was the most active aminoglycoside (27.1% of isolates were susceptible). Disk diffusion and Etest tended to be more accurate than the Vitek 2, Phoenix, and MicroScan automated systems; but errors were noted with all methods. The Vitek 2 instrument incorrectly reported that more than one-third of the isolates were susceptible to amikacin (a very major error). Isolates were polyclonal, with 26 distinct strains, and carried multiple AME genes unrelated to the strain type. The presence of the ant(2 '')-Ia gene was statistically associated with resistance to each aminoglycoside. The AME genotype accounted for the resistance profile observed in a minority of isolates, suggesting the involvement of multiple resistance mechanisms. Hospital pharmacy records indicated the preferential use of amikacin over other aminoglycosides in the burn intensive care unit, where aminoglycoside resistance is prevalent. The resistance in that unit did not correlate with a predominant strain, AME genotype, or total annual aminoglycoside consumption. Susceptibility to tobramycin increased, even though susceptible isolates carried AME genotypes predicting the inactivation of tobramycin. Determination of the relative contribution of multiple concurrent resistance mechanisms may improve our understanding of aminoglycoside resistance in the Acinetobacter baumannii-calcoaceticus complex.
C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA.
[Akers, Kevin S.; Chaney, Chris; Barsoumian, Alice; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA.
[Beckius, Miriam; Yu, Xin] San Antonio Mil Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[Guymon, Charles] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Keen, Edward F., III; Robinson, Brian J.] San Antonio Mil Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA.
[Keen, Edward F., III; Robinson, Brian J.] San Antonio Mil Med Ctr, Area Lab Serv, Ft Sam Houston, TX 78234 USA.
[Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM Clinton.Murray@amedd.army.mil
RI Valle, Ruben/A-7512-2013
FU U.S. Armed Forces Health Surveillance Center (AFHSC); Division of Global
Emerging Infections Surveillance and Response System (GEIS) Operations;
Infectious Diseases Clinical Research Program (IDCRP)
FX We gratefully acknowledge support from the U.S. Armed Forces Health
Surveillance Center (AFHSC) Division of Global Emerging Infections
Surveillance and Response System (GEIS) Operations and the Infectious
Diseases Clinical Research Program (IDCRP).
NR 37
TC 32
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U1 0
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD APR
PY 2010
VL 48
IS 4
BP 1132
EP 1138
DI 10.1128/JCM.02006-09
PG 7
WC Microbiology
SC Microbiology
GA 576OC
UT WOS:000276153200016
PM 20107089
ER
PT J
AU Kajon, AE
Dickson, LM
Metzgar, D
Houng, HS
Lee, V
Tan, BH
AF Kajon, Adriana E.
Dickson, Laura M.
Metzgar, David
Houng, Huo-Shu
Lee, Vernon
Tan, Boon-Huan
TI Outbreak of Febrile Respiratory Illness Associated with Adenovirus 11a
Infection in a Singapore Military Training Camp
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID GENOME TYPES; RECRUITS; DISEASE; PCR; HEALTHY; TYPE-11; ADULTS; GENE
AB Outbreak cases of acute respiratory disease (ARD) associated with subspecies B2 human adenovirus 11a (HAdV-11a) infection were detected during 2005 in a military basic training camp in Singapore. The Singapore HAdV-11a strain is highly similar to other Asian strains of HAdV-11, including strain QS-DLL, which is responsible for the recently described 2006 outbreak of ARD in China.
C1 [Kajon, Adriana E.; Dickson, Laura M.] LRRI, Program Infect Dis, Albuquerque, NM 87108 USA.
[Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, NHRC, San Diego, CA 92106 USA.
[Houng, Huo-Shu] Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD 20910 USA.
[Lee, Vernon] Biodef Ctr, Singapore 778910, Singapore.
[Tan, Boon-Huan] Def Med & Environm Res Inst, Detect & Diagnost Lab, DSO Natl Labs, Singapore 117510, Singapore.
RP Kajon, AE (reprint author), LRRI, Program Infect Dis, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108 USA.
EM akajon@lrri.org
RI Valle, Ruben/A-7512-2013
FU Global Emerging Infections Surveillance and Response System; Division of
the U.S. Armed Forces Health Surveillance Center; Henry M. Jackson
Foundation for the Advancement of Military Medicine; Singapore Ministry
of Defense
FX Funding for this work was provided by the Global Emerging Infections
Surveillance and Response System, a Division of the U.S. Armed Forces
Health Surveillance Center, the Henry M. Jackson Foundation for the
Advancement of Military Medicine, and the Singapore Ministry of Defense.
We declare that no financial conflict of interest exists.; Views and
opinions of and endorsements by the authors do not reflect those of the
U.S. Army or the Department of Defense (DoD), the Department of the
Navy, or the United States and Singapore governments. This research has
been conducted in compliance with all applicable federal and
international regulations governing the protection of human subjects in
research (DoD protocol NHRC. 1999.0002).
NR 36
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U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD APR
PY 2010
VL 48
IS 4
BP 1438
EP 1441
DI 10.1128/JCM.01928-09
PG 4
WC Microbiology
SC Microbiology
GA 576OC
UT WOS:000276153200064
PM 20129957
ER
PT J
AU Kwon, DH
Bennett, W
Herberg, S
Bastone, P
Pippig, S
Rodriguez, NA
Susin, C
Wikesjo, UME
AF Kwon, David H.
Bennett, William
Herberg, Samuel
Bastone, Patrizia
Pippig, Susanne
Rodriguez, Nancy A.
Susin, Cristiano
Wikesjoe, Ulf M. E.
TI Evaluation of an injectable rhGDF-5/PLGA construct for minimally
invasive periodontal regenerative procedures: a histological study in
the dog
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE bone; cementum; GDF-5; periodontal ligament; periodontal regeneration;
PLGA; tissue engineering
ID BONE MORPHOGENETIC PROTEIN-2; GUIDED TISSUE REGENERATION;
GROWTH/DIFFERENTIATION FACTOR-5; DIFFERENTIATION FACTORS;
CLINICAL-APPLICATIONS; OSTEOGENIC PROTEIN; GENE-EXPRESSION; ALVEOLAR
BONE; BETA FAMILY; RAT MODEL
AB P>Aim
To evaluate the injectability, biocompatibility, safety, and periodontal wound healing/regeneration following application of a novel bioresorbable recombinant human growth/differentiation factor-5 (rhGDF-5)/poly(lactic-co-glycolic acid) (PLGA) construct.
Material and Methods
Periodontal pockets (3 x 6 mm, width x depth) were surgically created over the buccal roots of the second and fourth mandibular pre-molars in eight adult Hound Labrador mongrel dogs. Surgeries including injection of the rhGDF-5/PLGA construct into the pockets were sequenced that four animals provided 2-/4-week and four animals 6-/8-week observations of sites receiving rhGDF-5/PLGA or serving as sham-surgery control.
Results
The rhGDF-5/PLGA construct was easy to prepare and apply. Approximately 0.2 ml (93 mu g rhGDF-5)/tooth was used. Clinical and radiographic healing was exemplary without adverse events. Healing was characterized by a non-specific connective tissue attachment, acellular/cellular cementum, periodontal ligament (PDL), bone regeneration, and a junctional epithelium. PLGA fragments were observed in 4/7, 2/8, and 1/8 sites at 2, 4, and 6 weeks, respectively. Associated inflammatory reactions exhibited no limiting effect on periodontal wound healing/regeneration. Root resorption/ankylosis was not observed. Bone formation showed apparent increased maturity (lamellar bone) at 6 weeks in sites receiving rhGDF-5/PLGA compared with the control. Both protocols exhibited significant increases in PDL, cementum, and bone regeneration over time, without significant differences between treatments. In time, PDL and cementum regeneration was twofold greater for the control at 4 weeks (p=0.04) while increased bone formation was observed at sites receiving rhGDF-5/PLGA (p < 0.01).
Conclusions
In conclusion, the rhGDF-5/PLGA construct appears to be a safe technology for injectable, ease-of-use application of rhGDF-5-stimulated periodontal wound healing/regeneration. Additional work to optimize the polymer carrier and rhGDF-5 release kinetics/dose might be required before evaluating the efficacy of this technology in clinical settings using minimally invasive approaches.
C1 [Kwon, David H.; Bennett, William; Herberg, Samuel; Susin, Cristiano; Wikesjoe, Ulf M. E.] Med Coll Georgia, Sch Dent, Dept Periodont, LAPCR, Augusta, GA 30912 USA.
[Kwon, David H.; Bennett, William; Herberg, Samuel; Susin, Cristiano; Wikesjoe, Ulf M. E.] Med Coll Georgia, Sch Dent, Dept Oral Biol, LAPCR, Augusta, GA 30912 USA.
[Kwon, David H.] USA, Adv Educ Program Periodont, Ft Gordon, GA USA.
[Bastone, Patrizia; Pippig, Susanne] Scil Technol GmbH, Martinsried, Germany.
[Rodriguez, Nancy A.] Med Coll Georgia, Lab Anim Serv, Augusta, GA 30912 USA.
RP Wikesjo, UME (reprint author), Med Coll Georgia, Sch Dent, Dept Periodont, LAPCR, AD 1430 1120 15th St, Augusta, GA 30912 USA.
EM uwikesjo@mcg.edu
RI Wikesjo, Ulf/A-4159-2009; Susin, Cristiano/B-9822-2008
OI Wikesjo, Ulf/0000-0003-1607-0583;
NR 50
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Z9 28
U1 0
U2 3
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0303-6979
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD APR
PY 2010
VL 37
IS 4
BP 390
EP 397
DI 10.1111/j.1600-051X.2010.01546.x
PG 8
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 571CM
UT WOS:000275728600010
PM 20447263
ER
PT J
AU Sharma, Y
Xu, T
Graf, WM
Fobbs, A
Sherwood, CC
Hof, PR
Allman, JM
Manaye, KF
AF Sharma, Yukti
Xu, Tao
Graf, Werner M.
Fobbs, Archie
Sherwood, Chet C.
Hof, Patrick R.
Allman, John M.
Manaye, Kebreten F.
TI Comparative Anatomy of the Locus Coeruleus in Humans and Nonhuman
Primates
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE locus coeruleus; nonhuman primates; hominids; tyrosine hydroxylase;
stereology
ID TYROSINE-HYDROXYLASE; BEHAVING RATS; DOPAMINERGIC INNERVATION; BRAIN;
NEURONS; NUMBER; EVOLUTION; CERULEUS; COMPLEX; MACAQUE
AB The locus coeruleus (LC) is a dense cluster of neurons that projects axons throughout the neuroaxis and is located in the rostral pontine tegmentum extending from the level of the inferior colliculus to the motor nucleus of the trigeminal nerve. LC neurons are lost in the course of several neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. In this study we used Nissl staining and tyrosine hydroxylase (TH) immunoreactivity to compare the human LC with that of closely related primate species, including great and lesser apes, and macaque monkeys. TH catalyzes the initial and rate-limiting step in catecholamine biosynthesis. The number of TH-immunoreactive (TH-ir) neurons was estimated in each species using stereologic methods. In the LC of humans the mean total number of TH-ir neurons was significantly higher compared to the other primates. Because the total number of TH-ir neurons in the LC was highly correlated with the species mean volume of the medulla oblongata, cerebellum, and neocortical gray matter, we conclude that much of the observed phylogenetic variation can be explained by anatomical scaling. Notably, the total number of LC neurons in humans was most closely predicted by the nonhuman allometric scaling relationship relative to medulla size, whereas the number of LC neurons in humans was considerably lower than predicted according to neocortex and cerebellum volume. J. Comp. Neurol. 518: 963-971,2010. (C) 2009 Wiley-Liss, Inc.
C1 [Sharma, Yukti; Xu, Tao; Graf, Werner M.; Manaye, Kebreten F.] Howard Univ, Dept Physiol & Biophys, Coll Med, Washington, DC 20059 USA.
[Fobbs, Archie] Walter Reed Army Med Ctr, Armed Forces Inst Pathol, Natl Museum Hlth & Med, Washington, DC 20307 USA.
[Sherwood, Chet C.] George Washington Univ, Dept Anthropol, Washington, DC 20052 USA.
[Hof, Patrick R.] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA.
[Hof, Patrick R.] New York Consortium Evolutionary Primatol, New York, NY USA.
[Allman, John M.] CALTECH, Div Biol, Pasadena, CA 91125 USA.
RP Manaye, KF (reprint author), Howard Univ, Dept Physiol & Biophys, Coll Med, 520 W St NW,Suite 2305, Washington, DC 20059 USA.
EM kmanaye@howard.edu
FU James McDonnell's Foundation [22002078]; NIH/NINDS [U54 NS39407,
NS42867]; National Science Foundation [BCS-0515484, BCS-0549117,
BCS-0827531, DGE-0801634]
FX Grant sponsor: the James McDonnell's Foundation; Grant number: 22002078;
Grant sponsor: NIH/NINDS; Grant numbers: U54 NS39407 (Specialized
Neuroscience Research Program) and NS42867; Grant sponsor: National
Science Foundation; Grant numbers: BCS-0515484, BCS-0549117,
BCS-0827531, and DGE-0801634.
NR 52
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Z9 8
U1 1
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9967
EI 1096-9861
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD APR 1
PY 2010
VL 518
IS 7
BP 963
EP 971
DI 10.1002/cne.22249
PG 9
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA 559OE
UT WOS:000274834200002
PM 20127761
ER
PT J
AU Blomberg, SB
Engel, RC
Sawyer, R
AF Blomberg, S. Brock
Engel, Rozlyn C.
Sawyer, Reid
TI On the Duration and Sustainability of Transnational Terrorist
Organizations
SO JOURNAL OF CONFLICT RESOLUTION
LA English
DT Article
DE conflict; terrorism; survival analysis
AB This article aims to improve scholars' understanding of how transnational terrorist organizations emerge, survive, thrive, and eventually die. The authors use a data set that catalogues terrorist organizations and their attacks over time (the ITERATE database of thousands of terrorist events from 1968 through 2007) and merge those data with socioeconomic information about the environment in which each attack occurs. They use these data to trace the life cycle pattern of terrorist activity and the organizations that perpetrate them. They identify at least two types of terrorist organizations recidivists and one-hit wonders. The authors find that recidivist organizations, those that have repeatedly attacked,are less likely to survive once political and socioeconomic factors have been included. However, they find that sporadic or one-hit wonders are not easily deterred by socioeconomic factors, leaving open a role for counterinsurgency tactics.
C1 [Blomberg, S. Brock] Claremont Mckenna Coll, Robert Day Sch Econ & Finance, Claremont, CA 91711 USA.
[Engel, Rozlyn C.; Sawyer, Reid] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
RP Blomberg, SB (reprint author), Claremont Mckenna Coll, Robert Day Sch Econ & Finance, Claremont, CA 91711 USA.
EM bblomberg@cmc.edu
NR 19
TC 23
Z9 23
U1 1
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-0027
J9 J CONFLICT RESOLUT
JI J. Confl. Resolut.
PD APR
PY 2010
VL 54
IS 2
SI SI
BP 303
EP 330
DI 10.1177/0022002709355431
PG 28
WC International Relations; Political Science
SC International Relations; Government & Law
GA 579KC
UT WOS:000276367800006
ER
PT J
AU Escobedo, A
Quinones, S
Adame, M
McClure, J
Zubia, D
Brill, G
AF Escobedo, A.
Quinones, S.
Adame, M.
McClure, J.
Zubia, D.
Brill, G.
TI Characterization of Smooth CdTe(111) Films by the Conventional
Close-Spaced Sublimation Technique
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article
DE CdTe; II-VI semiconductors; close-spaced sublimation (CSS); scanning
electron microscopy (SEM); x-ray diffraction (XRD)
ID MOLECULAR-BEAM EPITAXY; CHEMICAL-VAPOR-DEPOSITION; CDTE LAYERS;
SUBSTRATE ORIENTATION; PHASE EPITAXY; (111)B CDTE; SOLAR-CELLS; GROWTH;
HGCDTE; GAAS
AB Thin epitaxial CdTe films were grown on CdTe(111)B substrates by the close-spaced sublimation (CSS) technique and were characterized over a range of experimental parameters. The source temperature was varied between 480A degrees C and 540A degrees C, maintaining an average constant source-substrate temperature difference Delta T of similar to 130A degrees C. Helium was used as a carrier gas at pressures between 2 Torr and 10 Torr. Scanning electron microscopy (SEM) and x-ray diffraction (XRD) were used to analyze the film morphology and structure. Growth rates ranging from 1 mu m/h to 4 mu m/h were observed, based on profilometer thickness measurements. The addition of a pre-growth heat treatment step and post-growth annealing treatment resulted in smooth CdTe(111) films. An evolution in growth morphology was demonstrated with SEM images and film quality was confirmed with XRD.
C1 [Escobedo, A.; Quinones, S.; Adame, M.; Zubia, D.] Univ Texas El Paso, Dept Elect & Comp Engn, El Paso, TX 79968 USA.
[McClure, J.] Univ Texas El Paso, Dept Met & Mat Engn, El Paso, TX 79968 USA.
[Brill, G.] USA, Res Lab, Adelphi, MD USA.
RP Escobedo, A (reprint author), Univ Texas El Paso, Dept Elect & Comp Engn, El Paso, TX 79968 USA.
EM stellaq@utep.edu
RI Schaff, William/B-5839-2009; Brill, Gregory/G-4877-2013
FU Texas Instruments Foundation; National Science Foundation [0245071];
Forrest O. and Henrietta Lewis Foundation
FX This material is based upon work supported by the Texas Instruments
Foundation, the National Science Foundation under grant no. 0245071, and
the Forrest O. and Henrietta Lewis Foundation. Support received by all
NanoMaterials Integration Laboratory (NanoMIL) research members at The
University of Texas at El Paso (UTEP) is greatly appreciated.
NR 38
TC 11
Z9 11
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD APR
PY 2010
VL 39
IS 4
BP 400
EP 409
DI 10.1007/s11664-010-1082-y
PG 10
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA 573HN
UT WOS:000275900100007
ER
PT J
AU Philips, DA
Bauch, TD
AF Philips, David A.
Bauch, Terry D.
TI RAPID CORRECTION OF HYPOKALEMIA IN A PATIENT WITH AN IMPLANTABLE
CARDIOVERTER-DEFIBRILLATOR AND RECURRENT VENTRICULAR TACHYCARDIA
SO JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
DE hypokalemia; implantable cardioverter-defibrillator (ICD);
cardiomyopathy; potassium; ventricular tachycardia (VT)
ID POTASSIUM-CHLORIDE INFUSIONS; ANTIARRHYTHMIC-DRUG-THERAPY; SOTALOL;
ARRHYTHMIAS; AMIODARONE
AB We present the case of a 74-year-old man with non-ischemic dilatated cardiomyopathy and an implantable cardioverter-defibrillator presenting with a serum potassium of 2.6 mmol/L, recurrent unstable ventricular tachycardia, and multiple defibrillations. Administration of a rapid bolus of 20 mEq KCL solution via central venous access, followed by an additional total of 80 mEq (orally and intravenously [i.v.]) over the next 2 h, resulted in immediate resolution of his recurrent unstable dysrhythmia without toxic side effects. Guidelines for rapid correction of hypokalemia quote a maximum safe administration of 20 mEq i.v./h. In addition to discussing the clinical relevance and physiologic interactions of the variables leading to this patient's presentation, we discuss the successful termination of his sustained recurrent ventricular dysrhythmia by rapid potassium repletion above currently recommended rates. The patient we present is representative of a growing population, given medical and technological advances over the years. Potassium boluses may be reasonable in such circumstances, particularly in patients with ICDs. (C) 2010 Elsevier Inc.
C1 [Philips, David A.] Brooke Army Med Ctr, Dept Cardiol, San Antonio, TX 78209 USA.
[Bauch, Terry D.] Univ Texas Hlth Sci Ctr San Antonio, Serv Cardiol, Dept Med, San Antonio, TX 78229 USA.
RP Philips, DA (reprint author), Brooke Army Med Ctr, Dept Cardiol, San Antonio, TX 78209 USA.
NR 26
TC 1
Z9 1
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0736-4679
J9 J EMERG MED
JI J. Emerg. Med.
PD APR
PY 2010
VL 38
IS 3
BP 308
EP 316
DI 10.1016/j.jemermed.2007.06.019
PG 9
WC Emergency Medicine
SC Emergency Medicine
GA 581ZI
UT WOS:000276564200006
PM 18375090
ER
PT J
AU Lux, S
Gu, LF
Kopec, G
Bernas, R
Miley, G
AF Lux, Scott
Gu, Lifeng
Kopec, Grant
Bernas, Robert
Miley, George
TI Water Management Issues for Direct Borohydride/Peroxide Fuel Cells
SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY
LA English
DT Article
DE sodium borohydride; water management; hydrogen peroxide; fuel cell
ID SODIUM METABORATE; BORIC-ACID; HYDROGEN; GENERATION; CATALYST; CURVES;
OXIDE
AB This study evaluated water management strategies to lengthen the run time of a batch fueled direct sodium borohydride/peroxide (NaBH(4)/H(2)O(2)) proton exchange membrane fuel cell. The term "batch fueled" refers specifically to a fuel tank containing a fixed volume of fuels for use in the run. The length of a run using a fixed fuel tank is strongly influenced by water dynamics. The water that reacts at the anode is produced at the cathode, and is transported through the membrane via drag and diffusion. Resulting concentration changes in the fuel of the NaBH(4)/H(2)O(2) fuel cell were modeled to evaluate the run lifetime. The run time is defined as the amount of time required for NaBH(4) or for NaBO(2) (the byproduct compound) to reach either solubility limit or until the fuel is depleted, whichever occurs first. As part of the evaluation, an "effective" H(2)O drag coefficient (net drag minus back diffusion) with Nafion (R) 112 was experimentally determined to be 1.14 and 4.36 at 25 degrees C and 60 degrees C, respectively. The concentrations of the NaBH(4) and NaBO(2) solutions were calculated as a function of initial concentration, and for the case where H(2)O was supplied to the anode compartment during operation. Several strategies to increase the run time by both passive and active water management were considered. It is found that the run time is increased from 10 W h to 57 W h, with a decrease in the initial NaBH(4) concentration from 30 wt % (typically employed in these cells) to 10 wt %. Adding 0.125 ml/min H(2)O to the bulk anode solution increases the run time of a 10 wt % NaBH(4) solution by a factor of 1.6. Adding 0.225 ml/min H(2)O to 30 wt % NaBH(4) bulk solution increases the run time by a factor of 4.4. While attractive for increasing run time, the practicality of water addition depends on its availability or requires incorporation of an added unit, designed to separate and recirculate water from the cathode solution. [DOI: 10.1115/1.3176218]
C1 [Lux, Scott] USA, Erdc, CERL, Champaign, IL 61822 USA.
[Gu, Lifeng; Kopec, Grant; Bernas, Robert; Miley, George] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA.
RP Lux, S (reprint author), USA, Erdc, CERL, Champaign, IL 61822 USA.
FU NPL Associates, Inc. under DARPA [SB04-032, FA9453-05-C-0084];
Cooperative Research and Development Agreement with U. S. Army ERDC-CERL
[CRADA-07-CERL-01]
FX The authors thank NPL Associates, Inc. for sharing their original DBFC
technology for this work. This work was supported through NPL
Associates, Inc. under DARPA Contract Nos. SB04-032 and FA9453-05-C-0084
and a Cooperative Research and Development Agreement with U. S. Army
ERDC-CERL under Grant No. CRADA-07-CERL-01.
NR 14
TC 5
Z9 5
U1 0
U2 5
PU ASME-AMER SOC MECHANICAL ENG
PI NEW YORK
PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1550-624X
J9 J FUEL CELL SCI TECH
JI J. Fuel Cell Sci. Technol.
PD APR
PY 2010
VL 7
IS 2
AR 024501
DI 10.1115/1.3176218
PG 5
GA 549AN
UT WOS:000274013200025
ER
PT J
AU Pisarcik, S
Herbert, A
Olinger, G
AF Pisarcik, Sarah
Herbert, Andrew
Olinger, Gene
TI Alphavirus particle filovirus vaccine activation of Dendritic cells
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Pisarcik, Sarah; Herbert, Andrew; Olinger, Gene] US Army Med Res Inst Infect Dis, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2010
VL 184
SU 1
MA 52.7
PG 1
WC Immunology
SC Immunology
GA V44OM
UT WOS:000209758301172
ER
PT J
AU Patel, GK
Yee, CL
Montemorano, A
Maggio, K
Vogel, IC
AF Patel, G. K.
Yee, C. L.
Montemorano, A.
Maggio, K.
Vogel, I. C.
TI The role of cancer stem cells in the initiation and propagation of human
cutaneous squamous cell carcinoma in an in vivo model
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the Society-for-Investigative-Dermatology
CY MAY 05-08, 2010
CL Atlanta, GA
SP Soc Investtigat Dermatol
C1 [Patel, G. K.] Cardiff Univ, Dept Dermatol & Wound Healing, Cardiff, Wales.
[Patel, G. K.; Yee, C. L.; Vogel, I. C.] Natl Canc Inst, Dermatol Branch, Bethesda, MD USA.
[Montemorano, A.] Rockledge Skin Canc Clin, Bethesda, MD USA.
[Maggio, K.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2010
VL 130
SU 1
MA 167
BP S28
EP S28
PG 1
WC Dermatology
SC Dermatology
GA 580ND
UT WOS:000276455100165
ER
PT J
AU Cobb, BL
Crowe, SR
James, JA
Engler, RJ
Kaufman, KM
Harley, JB
AF Cobb, Beth L.
Crowe, Sherry R.
James, Judith A.
Engler, Renata J.
Kaufman, Kenneth M.
Harley, John B.
TI ANTHRAX VACCINE ADSORBED VACCINATION ANTI-PROTECTIVE ANTIGEN ANTIBODY
LEVELS ARE ASSOCIATED WITH SLC35F1, ST6GALNAC3 AND RGS6
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Meeting Abstract
CT Annual Combined Meeting of the
Central-Society-for-Clinical-Research/Midwestern Section of the
American-Federation-for-Medical-Research
CY APR 22-23, 2010
CL Chicago, IL
SP Cent Soc Clin Res, Amer Federat Med Res, Midwestern Sect
C1 [Cobb, Beth L.; Crowe, Sherry R.; James, Judith A.; Kaufman, Kenneth M.; Harley, John B.] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA.
[James, Judith A.; Kaufman, Kenneth M.; Harley, John B.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
[Engler, Renata J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1081-5589
J9 J INVEST MED
JI J. Invest. Med.
PD APR
PY 2010
VL 58
IS 4
MA 85
BP 669
EP 670
PG 2
WC Medicine, General & Internal; Medicine, Research & Experimental
SC General & Internal Medicine; Research & Experimental Medicine
GA 583ZL
UT WOS:000276719600097
ER
PT J
AU Grujicic, M
Pandurangan, B
Coutris, N
Cheeseman, BA
Roy, WN
Skaggs, RR
AF Grujicic, M.
Pandurangan, B.
Coutris, N.
Cheeseman, B. A.
Roy, W. N.
Skaggs, R. R.
TI Derivation, Parameterization and Validation of a Sandy-Clay Material
Model for Use in Landmine Detonation Computational Analyses
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE blast resistance; granular materials; material modeling
ID SATURATION; STRESS
AB A set of large-strain/high-deformation-rate/high-pressure material models for sand-based soils with different saturation levels and clay and gravel contents was recently proposed and validated in our study, and the same has been extended in this study to include clay-based soils of different saturation levels and sand contents. The model includes an equation of state which reveals the material response under hydrostatic pressure, a strength model which captures material elastic-plastic response under shear, and a failure model which defines the laws and conditions for the initiation and evolution of damage and ultimate failure of the material under negative pressure and/or shear. The model was first parameterized using various open-literature experimental results and property correlation analyses and, then, validated by comparing the computational results obtained in an ANSYS/Autodyn-based transient non-linear dynamics analysis of detonation of a landmine buried in sandy-clay with their experimental counterparts.
C1 [Grujicic, M.; Pandurangan, B.; Coutris, N.] Clemson Univ, Dept Mech Engn, ICAR, Clemson, SC 29634 USA.
[Cheeseman, B. A.; Roy, W. N.; Skaggs, R. R.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, ICAR, Clemson, SC 29634 USA.
EM mica.grujicic@ces.clemson.edu
FU U. S. Army/Clemson University Cooperative Agreements [W911NF-04-2-0024,
W911NF-06-2-0042]; U. S. Army [DAAD19-01-1-0661]; ARC-TARDEC
FX This study is based on the support provided by the U. S. Army/Clemson
University Cooperative Agreements, W911NF-04-2-0024 and
W911NF-06-2-0042, and by the U. S. Army Grant Number DAAD19-01-1-0661,
and through an ARC-TARDEC research contract.
NR 40
TC 6
Z9 6
U1 1
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD APR
PY 2010
VL 19
IS 3
BP 434
EP 450
DI 10.1007/s11665-009-9509-4
PG 17
WC Materials Science, Multidisciplinary
SC Materials Science
GA 568RU
UT WOS:000275541100017
ER
PT J
AU James, CD
McClain, J
Pohl, KR
Reuel, N
Achyuthan, KE
Bourdon, CJ
Rahimian, K
Galambos, PC
Ludwig, G
Derzon, MS
AF James, Conrad D.
McClain, Jaime
Pohl, Kenneth R.
Reuel, Nigel
Achyuthan, Komandoor E.
Bourdon, Christopher J.
Rahimian, Kamyar
Galambos, Paul C.
Ludwig, George
Derzon, Mark S.
TI High-efficiency magnetic particle focusing using dielectrophoresis and
magnetophoresis in a microfluidic device
SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING
LA English
DT Article
ID PATHOGEN DETECTION; ON-CHIP; SEPARATION; INSTRUMENTS; SIMULANTS;
CHANNELS; AGENTS; ELISA; FOOD
AB We describe a novel technique that utilizes simultaneous implementation of dielectrophoresis (DEP) and magnetophoresis (MAP) to focus magnetic particles into streams for optical analysis of biological samples. This technique does not require sheath flow and utilizes a novel interdigitated electrode array chip that yields multiple streams of flowing magnetic particles in single-file columns. The MAP force placed particles in close proximity to the microelectrodes where they were subjected to a strong DEP force that generated the particle focusing effect. Particle focusing efficiency was improved using this combination DEP-MAP technique compared to DEP alone: particle stream widths were reduced similar to 47% and stream width variability was reduced 80% for focused streams of 8.5 mu m diameter magnetic particles. 3 mu m diameter magnetic particles were strongly focused with DEP-MAP (similar to 4 mu m wide streams with sub-mu m variability in stream width) while DEP alone provided minimal focusing. Additional components of a prototype detection system were also demonstrated including an integrated magnetic pelleting component, a hand-held MHz frequency signal generator and a bench-top near-confocal microscope for optical analysis of flowing particles. Preliminary testing of a sandwich assay performed on the surface of magnetic particles showed 50 ppb detection levels of a surrogate biotoxin (ovalbumin) in a raw milk sample.
C1 [James, Conrad D.; McClain, Jaime; Pohl, Kenneth R.; Achyuthan, Komandoor E.; Bourdon, Christopher J.; Rahimian, Kamyar; Galambos, Paul C.; Derzon, Mark S.] Sandia Natl Labs, Albuquerque, NM 87185 USA.
[Reuel, Nigel] MIT, Cambridge, MA 02139 USA.
[Ludwig, George] USA, Med Res & Mat Command, Frederick, MD 21702 USA.
RP James, CD (reprint author), Sandia Natl Labs, Albuquerque, NM 87185 USA.
EM cdjame@sandia.gov
FU United States Department of Energy [DE-AC04-94AL85000]
FX The authors thank Vickie Peck, Matthew Hopkins, James Cullor and Paul
Rossitto for useful discussions, and Darin Graf, Cody Washburn, Patty
Sawyer and John Anderson for device fabrication and experimental
support. This work was funded by Sandia's Laboratory Directed Research
and Development program. Sandia National Laboratories is a multiprogram
laboratory operated by Sandia Corporation, a Lockheed Martin Company,
for the United States Department of Energy under contract
DE-AC04-94AL85000.
NR 32
TC 16
Z9 16
U1 2
U2 14
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0960-1317
J9 J MICROMECH MICROENG
JI J. Micromech. Microeng.
PD APR
PY 2010
VL 20
IS 4
AR 045015
DI 10.1088/0960-1317/20/4/045015
PG 9
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Instruments & Instrumentation; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Instruments &
Instrumentation; Physics
GA 572OG
UT WOS:000275841800016
ER
PT J
AU Rafuse, ES
AF Rafuse, Ethan S.
TI West Pointers and the Civil War: The Old Army in War and Peace.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2010
VL 74
IS 2
BP 597
EP 598
PG 2
WC History
SC History
GA 581KO
UT WOS:000276521600036
ER
PT J
AU Short, CA
AF Short, Courtney A.
TI Japanese Assimilation Policies in Colonial Korea 1910-1945.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Short, Courtney A.] US Mil Acad, West Point, NY 10996 USA.
RP Short, CA (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2010
VL 74
IS 2
BP 609
EP 610
PG 2
WC History
SC History
GA 581KO
UT WOS:000276521600045
ER
PT J
AU Stentiford, BM
AF Stentiford, Barry M.
TI Guarding the Border: The Military Memoirs of Ward Schrantz, 1912-1917.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Stentiford, Barry M.] Sch Adv Mil Studies, Ft Leavenworth, KS USA.
RP Stentiford, BM (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2010
VL 74
IS 2
BP 611
EP 612
PG 2
WC History
SC History
GA 581KO
UT WOS:000276521600046
ER
PT J
AU Bielakowski, AM
AF Bielakowski, Alexander M.
TI Tank Men: The Human Story of Tanks at War.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Bielakowski, Alexander M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
RP Bielakowski, AM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2010
VL 74
IS 2
BP 619
EP 620
PG 2
WC History
SC History
GA 581KO
UT WOS:000276521600052
ER
PT J
AU House, JM
AF House, Jonathan M.
TI The Second World War on the Eastern Front.
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2010
VL 74
IS 2
BP 633
EP 634
PG 2
WC History
SC History
GA 581KO
UT WOS:000276521600061
ER
PT J
AU Betros, L
AF Betros, Lance
TI American Civil-Military Relations: The Soldier and the State in a New
Era
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Betros, Lance] US Mil Acad, West Point, NY 10996 USA.
RP Betros, L (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
J9 J MILITARY HIST
JI J. Mil. Hist.
PD APR
PY 2010
VL 74
IS 2
BP 657
EP 659
PG 3
WC History
SC History
GA 581KO
UT WOS:000276521600078
ER
PT J
AU Crowell, HP
Milner, CE
Hamill, J
Davis, IS
AF Crowell, Harrison Philip
Milner, Clare E.
Hamill, Joseph
Davis, Irene S.
TI Reducing Impact Loading During Running With the Use of Real-Time Visual
Feedback
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE accelerometer; gait retraining; ground reaction forces; stress fracture;
tibia
ID GROUND REACTION FORCES; STRESS-FRACTURES; LOWER-EXTREMITY; ORTHOTIC
DEVICE; SHOCK; INSTRUCTION; JUMP; BIOFEEDBACK; PREVENTION; INJURIES
AB STUDY DESIGN: Single-subject with repeated measures.
OBJECTIVES: To determine if runners can use real-time visual feedback from an accelerometer to achieve immediate reductions in tibial acceleration and vertical-force loading rates.
BACKGROUND: Stress fractures are a common injury among runners. Previous studies suggest that runners with higher than normal tibial acceleration and vertical-force loading rates are at increased risk for tibial stress fractures. If these runners can be trained to reduce the loading on their lower extremities, it may reduce their risk of stress fractures.
METHODS: five subjects participated in this study. All subjects ran on a treadmill, instrumented with force transducers, during a single 30-minute session that was divided into warm-up, feedback, no-feedback, and cool-down periods. During running, the subjects also wore an accelerometer taped to their distal right tibia. Peak positive acceleration of the tibia, vertical force impact peak, and average and instantaneous vertical-force loading rates were assessed at the end of the warm-up, feedback, and no-feedback periods.
RESULTS: Single-subject analysis revealed that 4 of the 5 subjects had significant reductions in their peak positive acceleration at the end of the no-feedback period compared to the warm-up. In addition, all of the subjects had significant decreases in impact peak and vertical ground reaction force loading rates at the end of the no feedback period.
CONCLUSION: In a single session of training with real-time visual feedback, it appears that most runners can reduce the types of lower extremity loading associated with stress fractures. This may lead to training programs that reduce the risk of stress fractures for runners,
LEVEL OF EVIDENCE: Prevention, level 5. J Orthop Sports Phys Ther 2010;40(4):206-213. doi:10.2519/jospt.2010.3166
C1 [Crowell, Harrison Philip] USA, Res Lab, RDRL HRS B, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Milner, Clare E.] Univ Tennessee, Dept Exercise Sport & Leisure Studies, Knoxville, TN USA.
[Hamill, Joseph] Univ Massachusetts, Dept Kinesiol, Amherst, MA 01003 USA.
[Davis, Irene S.] Univ Delaware, Dept Phys Therapy, Newark, DE USA.
[Davis, Irene S.] Drayer Phys Therapy Inst, Hummelstown, PA USA.
RP Crowell, HP (reprint author), USA, Res Lab, RDRL HRS B, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM harrison.philip.crowell@us.army.mil
OI Milner, Clare/0000-0002-8267-605X
FU Department of Defense [DAMD17-00-1-0515]
FX This work was supported by Department of Defense grant DAMD17-00-1-0515.
NR 43
TC 50
Z9 51
U1 0
U2 31
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD APR
PY 2010
VL 40
IS 4
BP 206
EP 213
DI 10.2519/jospt.2010.3166
PG 8
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 578UV
UT WOS:000276322500003
PM 20357417
ER
PT J
AU Hsu, JR
Stinner, DJ
Brown, DA
AF Hsu, Joseph R.
Stinner, Daniel J.
Brown, David A.
CA Skeletal Trauma Res Consortium STR
TI Splitting of the Proximal Femur With a New Femoral Nail
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE lateral entry; trochanteric nail; intramedullary nailing; femur;
complication
ID ENTRY POINT; GAMMA-NAIL; SHAFT FRACTURES; INSERTION; TROCHANTER; INJURY
AB We present a case of a 19-year-old woman with a closed diaphyseal femur fracture and who had fixation of the fracture using a newer lateral entry nail, which resulted in an intraoperative proximal femur fracture. The patient underwent revision the following day and subsequently returned to regular activity without signs of implant failure or loss of reduction at latest follow-up. Caution should be exercised with the use of new implants that require a change in customary technique. In addition, some concern must be raised by the amount of offset from the top of this particular nail to its long axis.
C1 [Hsu, Joseph R.; Stinner, Daniel J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Brown, David A.] Brooke Army Med Ctr, Orthoped Serv, Ft Sam Houston, TX 78234 USA.
EM daniel.stinner@amedd.army.mil
OI Stinner, Daniel/0000-0002-8981-6262
NR 18
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD APR
PY 2010
VL 24
IS 4
BP E40
EP E43
DI 10.1097/BOT.0b013e3181a53790
PG 4
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA 578XB
UT WOS:000276329000015
PM 20335750
ER
PT J
AU Oetgen, ME
Walick, KS
Tulchin, K
Karol, LA
Johnston, CE
AF Oetgen, Matthew E.
Walick, Kristina S.
Tulchin, Kirsten
Karol, Lori A.
Johnston, Charles E.
TI Functional Results After Surgical Treatment for Congenital Knee
Dislocation
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE functional outcome; congenital deformity; knee dislocation
AB Background: Congenital knee dislocation (CDK) is a rare congenital deformity, which often requires surgery for treatment. Little objective data exist characterizing the outcome of patients who require operative treatment for this condition. The purposes of this study were to objectively evaluate the functional, clinical, and gait outcomes of patients who underwent surgical treatment of CDK; and compare the results of outcome between 2 surgical approaches for this condition: quadricepsplasty and femoral shortening.
Methods: We performed a retrospective review of all patients (7) treated surgically for CDK. Patients were evaluated at an average follow-up of 12+6 years. Each patient underwent a clinical examination, functional evaluation using the Lysholm Knee Questionnaire and Pediatric Outcomes Data Collection Instrument, and a 3-dimensional gait evaluation. The results of the total group were compared with normal controls. Additionally, results of the patients treated with quadricepsplasty were compared with patients treated with femoral shortening.
Results: Total knee range of motion for the entire group averaged 112 degrees, with 8 of the 9 knees having flexion>90 degrees. Seven of the 9 knees were found to have some degree of instability on examination, yet none of the patients reported using any form of brace for ambulation. Functional evaluation showed good knee specific and overall function, comparable to normal controls. There were no differences in clinical or functional outcomes between the 2 surgical approaches. Gait analysis revealed a stiff-knee gait pattern to the congenital knee dislocation group, as compared with normal controls, and subtle differences in knee function between the surgical approaches.
Conclusions: The function of patients after surgical treatment for CDK seems to be quite good compared with normal controls. Good knee specific and overall function scores are reported with limitations seen only in higher demand activities. Despite instability of the knee noticed on clinical examination, patients ambulate without braces and have a functional knee range of motion. Little difference in outcome was seen between the 2 surgical approaches used to treat this condition.
C1 [Oetgen, Matthew E.; Tulchin, Kirsten; Karol, Lori A.; Johnston, Charles E.] Texas Scottish Rite Hosp Children, Dallas, TX 75219 USA.
[Walick, Kristina S.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
RP Johnston, CE (reprint author), Texas Scottish Rite Hosp Children, 2222 Welborn St, Dallas, TX 75219 USA.
EM Charles.Johnston@tsrh.org
NR 20
TC 9
Z9 9
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-6798
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD APR-MAY
PY 2010
VL 30
IS 3
BP 216
EP 223
DI 10.1097/BPO.0b013e3181d48375
PG 8
WC Orthopedics; Pediatrics
SC Orthopedics; Pediatrics
GA 573XU
UT WOS:000275950600002
PM 20357585
ER
PT J
AU Sanan, TT
Muthukrishnan, S
Beck, JM
Tao, P
Hayes, CJ
Otto, TC
Cerasoli, DM
Lenz, DE
Hadad, CM
AF Sanan, Toby T.
Muthukrishnan, Sivaramakrishnan
Beck, Jeremy M.
Tao, Peng
Hayes, Carrigan J.
Otto, Tamara C.
Cerasoli, Douglas M.
Lenz, David E.
Hadad, Christopher M.
TI Computational modeling of human paraoxonase 1: preparation of protein
models, binding studies, and mechanistic insights
SO JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
LA English
DT Article; Proceedings Paper
CT International Symposium on Reactive Intermediates and Unusual Molecules
CY JUL 05-10, 2009
CL Liblice, CZECH REPUBLIC
DE bioscavenger; catalytic hydrolysis; organophosphorus compounds;
paraoxonase
ID DENSITY-FUNCTIONAL THERMOCHEMISTRY; HUMAN SERUM PARAOXONASE; DIISOPROPYL
FLUOROPHOSPHATASE; MOLECULAR-DYNAMICS; POTENTIAL FUNCTIONS; LACTONASE
ACTIVITY; LIQUID WATER; FORCE-FIELD; HYDROLYSIS; EXCHANGE
AB The enzyme human paraoxonase 1 (huPON1) has demonstrated significant potential for use as a bioscavenger for treatment of exposure to organophosphorus (OP) nerve agents. Herein we report the development of protein models for the human isoform derived from a crystal structure of a chimeric version of the protein (pdb ID: 1V04) and a homology model derived from the related enzyme diisopropylfluorophosphatase (pdb ID: 1XHR). From these structural models, binding modes for OP substrates are predicted, and these poses are found to orient substrates in proximity to residues known to modulate specificity of the enzyme. Predictions are made with regard to the role that residues play in altering substrate binding and turnover, in particular with regard to the stereoselectivity of the enzyme, and the known differences in activity related to a natural polymorphism in the enzyme. Potential mechanisms of action of the protein for catalytic hydrolysis of OP substrates are also evaluated in light of the proposed binding modes. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Sanan, Toby T.; Muthukrishnan, Sivaramakrishnan; Beck, Jeremy M.; Tao, Peng; Hayes, Carrigan J.; Hadad, Christopher M.] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA.
[Otto, Tamara C.; Cerasoli, Douglas M.; Lenz, David E.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA.
RP Hadad, CM (reprint author), Ohio State Univ, Dept Chem, 100 W 18th Ave, Columbus, OH 43210 USA.
EM hadad.1@osu.edu
RI Tao, Peng/H-4925-2014;
OI Tao, Peng/0000-0002-2488-0239; Hadad, Christopher/0000-0003-1211-4315
FU National Institutes of Health [U54-N5058183]
FX We gratefully acknowledge financial support of this research by the
National Institutes of Health (U54-N5058183). Generous computational
resources have been provided by the Ohio Supercomputer Center. We also
acknowledge fruitful and insightful discussions with Professor Thomas
Magliery (OSU). The opinions or assertions contained herein are the
private views of the authors and are not to be construed as official or
as reflecting the views of the United States Army or the Department of
Defense.
NR 57
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Z9 12
U1 1
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0894-3230
EI 1099-1395
J9 J PHYS ORG CHEM
JI J. Phys. Org. Chem.
PD APR
PY 2010
VL 23
IS 4
SI SI
BP 357
EP 369
DI 10.1002/poc.1678
PG 13
WC Chemistry, Organic; Chemistry, Physical
SC Chemistry
GA 584UG
UT WOS:000276778100012
PM 24077808
ER
PT J
AU Utz, ER
Elster, EA
Tadaki, DK
Gage, F
Perdue, PW
Forsberg, JA
Stojadinovic, A
Hawksworth, JS
Brown, TS
AF Utz, Edward R.
Elster, Eric A.
Tadaki, Douglas K.
Gage, Frederick
Perdue, Philip W.
Forsberg, Jonathan A.
Stojadinovic, Alexander
Hawksworth, Jason S.
Brown, Trevor S.
TI Metalloproteinase Expression is Associated with Traumatic Wound Failure
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Luminex; MMP-2; MMP-3; MMP-7; effluent; multiplex; dehiscence; acute
wound; VAC
ID OPERATION IRAQI FREEDOM; GINGIVAL CREVICULAR FLUID; MATRIX
METALLOPROTEINASES; EXTREMITY WOUNDS; ENDURING FREEDOM; THERAPY; BLAST;
MECHANISMS; INJURIES; BIOLOGY
AB Background. Matrix metalloproteinases (MMPs) are crucial in the inflammatory and remodeling phases of wound healing. We previously reported the correlation between pro-inflammatory cytokines and timing of successful combat-wound closure. We now extend our studies to investigate the correlation between wound-remodeling MMP expression and wound healing.
Methods. Thirty-eight wounds in 25 patients with traumatic extremity combat wounds were prospectively studied. Surgical debridement with vacuum-assisted closure (VAC) device application was repeated every 48 to 72h until surgical wound closure. Wound effluent and patient serum were collected at each wound debridement and analyzed for five matrix metalloproteinases using the Luminex multiplex system; Millipore Corp, Billerica, MA. The primary outcome was wound healing within 30 d of definitive wound closure. Impairment was defined as delayed wound closure (>21 d from injury) or wound dehiscence. MMP expression was compared between impaired and normal healing wounds.
Results. Elevated levels of serum MMP-2 and MMP-7 and reduced levels of effluent MMP3 were seen in impaired wounds (n = 9) compared with wounds that healed (n = 29; P<0.001). Receiver operating characteristic (ROC) curve analysis yielded area-under-the-curve (AUC) of 0.744, 0.783, and 0.805, respectively.
Conclusions. Impaired wound healing is characterized by pro-inflammatory MMP-2 and MMP-7. Serum and effluent concentrations of MMP-2, MMP-3, and MMP-7 can effectively predict the outcome of traumatic war wounds and can potentially provide decision-supportive, objective evidence for the timing of wound closure. Published by Elsevier Inc.
C1 [Utz, Edward R.; Elster, Eric A.; Tadaki, Douglas K.; Gage, Frederick; Forsberg, Jonathan A.; Hawksworth, Jason S.; Brown, Trevor S.] USN, Med Res Ctr, Regenerat Med Dept, Silver Spring, MD 20910 USA.
[Stojadinovic, Alexander; Hawksworth, Jason S.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
[Utz, Edward R.; Elster, Eric A.; Tadaki, Douglas K.; Forsberg, Jonathan A.; Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
[Elster, Eric A.; Perdue, Philip W.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA.
[Forsberg, Jonathan A.] Walter Reed Natl Mil Med Ctr, Integrated Dept Orthopaed & Rehabil, Bethesda, MD USA.
RP Brown, TS (reprint author), USN, Med Res Ctr, Regenerat Med Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Trevor.Brown@med.navy.mil
RI Brown, Trevor/K-4703-2012; Brown, Trevor/F-7392-2015
OI Brown, Trevor/0000-0001-7042-785X; Brown, Trevor/0000-0001-7042-785X
FU U.S. Navy Bureau of Medicine and Surgery [PE 0604771 N]; Alpha Omega
Alpha Carolyn L. Kuckein Student Research Fellowship
FX The multidisciplinary care of these patients would not have been
possible without the dedicated efforts of everyone at NNMC. Both
civilian and military personnel have rendered skilled and compassionate
care for these casualties. All of our efforts are dedicated to those who
have been placed in harm's way for the good of our nation. This effort
was supported (in part) by the U.S. Navy Bureau of Medicine and Surgery
under the Medical Development Program (PE 0604771 N) and in part by an
Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship.
NR 27
TC 38
Z9 38
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
J9 J SURG RES
JI J. Surg. Res.
PD APR
PY 2010
VL 159
IS 2
BP 633
EP 639
DI 10.1016/j.jss.2009.08.021
PG 7
WC Surgery
SC Surgery
GA 575MU
UT WOS:000276072000005
PM 20056248
ER
PT J
AU Pinholt, E
Castro, E
Mitchell, J
Butler, J
AF Pinholt, E.
Castro, E.
Mitchell, J.
Butler, J.
TI When Providers Find a Loaded Gun: Advocating Gun Safety Competency for
Home Visit Providers.
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Geriatrics-Society
CY MAY 12-15, 2010
CL Orlando, FL
SP Amer Geriatr Soc
C1 [Pinholt, E.; Castro, E.; Mitchell, J.; Butler, J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0002-8614
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD APR
PY 2010
VL 58
SU 1
BP 79
EP 80
PG 2
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA 577TO
UT WOS:000276247100228
ER
PT J
AU Zivan, L
Tischler, MB
AF Zivan, Lior
Tischler, Mark B.
TI Development of a Full Flight Envelope Helicopter Simulation Using System
Identification
SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY
LA English
DT Article; Proceedings Paper
CT 63rd Annual Forum of the American-Helicopter-Society
CY MAY 01-03, 2007
CL Virginia Beach, VA
SP Amer Helicopter Soc
AB Frequency-domain system identification techniques were used to develop a series of mathematical models of the Bell 206 helicopter, each valid at different flight conditions. The models were combined and "stitched" together to produce a continuous full flight envelope model of the helicopter. The model was implemented in a simple simulator and evaluated by several pilots, all flight qualified in this helicopter. It was the opinion of the pilots that the simulation is a good representation of the aircraft for all tasks of interest.
C1 [Zivan, Lior] Ben Gurion Int Airport, Israel Aerosp Ind, Div Engn, Flight Control Syst Dept, Tel Aviv, Israel.
[Tischler, Mark B.] USA, Res Dev & Engn Command, Ames Res Ctr, Moffett Field, CA USA.
RP Zivan, L (reprint author), Ben Gurion Int Airport, Israel Aerosp Ind, Div Engn, Flight Control Syst Dept, Tel Aviv, Israel.
EM lzivan@iai.co.il
NR 13
TC 3
Z9 3
U1 0
U2 5
PU AMER HELICOPTER SOC INC
PI ALEXANDRIA
PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA
SN 0002-8711
J9 J AM HELICOPTER SOC
JI J. Am. Helicopter Soc.
PD APR
PY 2010
VL 55
IS 2
AR 022003
DI 10.4050/JAHS.55.022003
PG 15
WC Engineering, Aerospace
SC Engineering
GA 745OV
UT WOS:000289175900003
ER
PT J
AU Gould, M
Adler, A
Zamorski, M
Castro, C
Hanily, N
Steele, N
Kearney, S
Greenberg, N
AF Gould, Matthew
Adler, Amy
Zamorski, Mark
Castro, Carl
Hanily, Natalie
Steele, Nicole
Kearney, Steve
Greenberg, Neil
TI Do stigma and other perceived barriers to mental health care differ
across Armed Forces?
SO JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
LA English
DT Article
ID MILITARY PERSONNEL; PSYCHOLOGICAL ILLNESS; SERVICE PERSONNEL; IRAQ WAR;
COMBAT; POPULATION; DISORDERS; SAMPLE
AB Objectives Military organizations are keen to address barriers to mental health care yet stigma and barriers to care remain little understood, especially potential cultural differences between Armed Forces. The aim of this study was to compare data collected by the US, UK, Australian, New Zealand and Canadian militaries using Hoge et al.'s perceived stigma and barriers to care measure (Combat duty in Iraq and Afghanistan, mental health problems and barriers to care. New Engl J Med 2004;351:13-22).
Design Each member country identified data sources that had enquired about Hoge et al.'s perceived stigma and perceived barriers to care items in the re-deployment or immediate post-deployment period. Five relevant statements were included in the study.
Setting US, UK Australian, New Zealand and Canadian Armed Forces.
Results Concerns about stigma and barriers to care tended to be more prominent among personnel who met criteria for a mental health problem. The pattern of reported stigma and barriers to care was similar across the Armed Forces of all five nations.
Conclusions Barriers to care continue to be a major issue for service personnel within Western military forces. Although there are policy, procedural and cultural differences between Armed Forces, the nations studied appear to share some similarities in terms of perceived stigma and barriers to psychological care. Further research to understand patterns of reporting and subgroup differences is required.
C1 [Greenberg, Neil] Kings Coll London, Acad Ctr Def Mental Hlth, Weston Educ Ctr, London SE5 9RJ, England.
[Gould, Matthew] DCMH, UK Minist Def, Def Clin Psychol Serv, Portsmouth PO1 3LT, Hants, England.
[Adler, Amy] US Army Med Res Unit Europe, D-69126 Heidelberg, Germany.
[Zamorski, Mark] Canadian Forces Hlth Serv Grp, Ottawa, ON K1A 0KG, Canada.
[Castro, Carl] Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD 20910 USA.
[Hanily, Natalie] Psychol Support Sect S Queensland, Enoggera, Qld 4035, Australia.
[Steele, Nicole] Joint Hlth Command CP 2 7 098, Canberra, ACT 2600, Australia.
[Kearney, Steve] HQ Joint Forces, Wellington, New Zealand.
RP Greenberg, N (reprint author), Kings Coll London, Acad Ctr Def Mental Hlth, Weston Educ Ctr, Cutcombe Rd, London SE5 9RJ, England.
EM sososanta@aol.com
NR 26
TC 49
Z9 49
U1 2
U2 13
PU ROYAL SOC MEDICINE PRESS LTD
PI LONDON
PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND
SN 0141-0768
J9 J ROY SOC MED
JI J. R. Soc. Med.
PD APR
PY 2010
VL 103
IS 4
BP 148
EP 156
DI 10.1258/jrsm.2010.090426
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA 619NL
UT WOS:000279436800011
PM 20382906
ER
PT J
AU Yokota, M
Berglund, LG
Bathalon, GP
AF Yokota, Miyo
Berglund, Larry G.
Bathalon, Gaston P.
TI Monte Carlo simulations of individual variability and their effects on
simulated heat stress using thermoregulatory modeling
SO JOURNAL OF THERMAL BIOLOGY
LA English
DT Article
DE Anthropometry; Monte Carlo; Thermal regulatory model; Heat stress; Core
temperature
ID RESPONSES; WORK
AB This paper addresses a variable-dependence (VD) MC method developed based on a previous attempt (VI-MC method) (J. Therm. Biol. 29 (2004), 515) to be incorporated in a thermoregulatory model. Simulated individuals with anthropometrics by VI- and VD-MC methods for US Army population were compared using principal component analysis and Fisher's exact tests. The results indicated that VD-MC data represented overall body size as the primary component and body shape as the secondary component that were more realistic and similar to the measured US Army data (p > 0.05) rather than VI-MC data (p < 0.05). Such differences consequently affected individual thermoregulatory responses to simulated heat stress. The VD-MC method provides a more realistic representation of individual variability and thus underpins more realistic predictions of individual thermoregulatory responses. Published by Elsevier Ltd.
C1 [Yokota, Miyo; Berglund, Larry G.; Bathalon, Gaston P.] USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA.
RP Yokota, M (reprint author), USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA.
EM Miyo.Yokota@us.army.mil
NR 20
TC 3
Z9 3
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4565
J9 J THERM BIOL
JI J. Therm. Biol.
PD APR
PY 2010
VL 35
IS 3
BP 154
EP 159
DI 10.1016/j.jtherbio.2010.02.002
PG 6
WC Biology; Zoology
SC Life Sciences & Biomedicine - Other Topics; Zoology
GA 579MF
UT WOS:000276374100008
ER
PT J
AU Milner, EE
AF Milner, Erin Elizabeth
TI The Grandfather of Organic Chemistry: Robert Burns Woodward, PhD
SO LABMEDICINE
LA English
DT Biographical-Item
C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Milner, EE (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
NR 1
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CLINICAL PATHOLOGY
PI CHICAGO
PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA
SN 0007-5027
J9 LABMEDICINE
JI Labmedicine
PD APR
PY 2010
VL 41
IS 4
BP 245
EP 246
DI 10.1309/LM7LBJZCC20JLKSD
PG 2
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 575BN
UT WOS:000276039000010
ER
PT J
AU St-Louis, V
Pidgeon, AM
Clayton, MK
Locke, BA
Bash, D
Radeloff, VC
AF St-Louis, Veronique
Pidgeon, Anna M.
Clayton, Murray K.
Locke, Brian A.
Bash, Dallas
Radeloff, Volker C.
TI Habitat variables explain Loggerhead Shrike occurrence in the northern
Chihuahuan Desert, but are poor correlates of fitness measures
SO LANDSCAPE ECOLOGY
LA English
DT Article
DE Loggerhead Shrike; Chihuahuan Desert; Habitat use; Habitat quality;
Fitness; Multi-scale habitat associations; Image texture
ID SPARROW AMPHISPIZA-BILINEATA; SATELLITE IMAGE TEXTURE; NESTING SUCCESS;
REPRODUCTIVE SUCCESS; VEGETATION STRUCTURE; BREEDING SUCCESS; GRASSLAND
BIRDS; DENSITY; MODELS; CONSERVATION
AB Conservation efforts should be based on habitat models that identify areas of high quality and that are built at spatial scales that are ecologically relevant. In this study, we developed habitat models for the Loggerhead Shrike (Lanius ludovicianus) in the Chihuahuan Desert of New Mexico to answer two questions: (1) are highly used habitats of high quality for shrikes in terms of individual fitness? and (2) what are the spatial scales of habitat associations relevant to this species? Our study area was Fort Bliss Army Reserve (New Mexico). Bird abundance was obtained from 10 min point counts conducted at forty-two 108 ha plots during a 3-year period. Measures of fitness were obtained by tracking a total of 73 nests over the 3 years. Habitat variables were measured at spatial scales ranging from broad to intermediate to local. We related habitat use and measures of fitness to habitat variables using Bayesian model averaging. We found a significant relationship between bird abundance and measures of fitness averaged across nesting birds in each plot (correlation up to 0.61). This suggests that measures of habitat use are indicative of habitat quality in the vicinity of Fort Bliss. Local- and intermediate-scale variables best explained shrike occurrence. Habitat variables were not related to any measures of fitness. A better understanding of the factors that limit individual bird fitness is therefore necessary to identify areas of high conservation value for this species.
C1 [St-Louis, Veronique; Pidgeon, Anna M.; Radeloff, Volker C.] Univ Wisconsin, Dept Forest & Wildlife Ecol, Madison, WI 53706 USA.
[Clayton, Murray K.] Univ Wisconsin, Dept Stat, Madison, WI 53706 USA.
[Locke, Brian A.; Bash, Dallas] IMWE PWD E, Div Environm, DPW, Ft Bliss, TX 79916 USA.
RP St-Louis, V (reprint author), Brown Univ, Environm Change Initiat, Box 1951, Providence, RI 02912 USA.
EM veroniquestlouis@gmail.com
RI Radeloff, Volker/B-6124-2016
OI Radeloff, Volker/0000-0001-9004-221X
NR 56
TC 6
Z9 6
U1 2
U2 24
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-2973
J9 LANDSCAPE ECOL
JI Landsc. Ecol.
PD APR
PY 2010
VL 25
IS 4
BP 643
EP 654
DI 10.1007/s10980-010-9451-8
PG 12
WC Ecology; Geography, Physical; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 567JY
UT WOS:000275444100012
ER
PT J
AU Steere, PJ
AF Steere, Paul J.
TI CONGRESS CREATES SUPER FEDERAL LIBRARY AGENCY
SO LIBRARY JOURNAL
LA English
DT Article
C1 [Steere, Paul J.] USA, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 18
EP 21
PG 4
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400006
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI The Ice Road: An Epic Journey from the Stalinist Labor Camps to Freedom
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 85
EP 85
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400134
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Winston's War: Churchill, 1940-1945
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 85
EP 86
PG 2
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400135
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI On the Front Lines of the Cold War: An American Correspondent's Journal
from the Chinese Civil War to the Cuban Missile Crisis and Vietnam
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 85
EP 85
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400133
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Every Man in This Village Is a Liar: An Education in War
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 85
EP 85
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400132
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Fighter Pilot: The Memoirs of Legendary Ace Robin Olds
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 85
EP 85
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400131
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Kaboom: Embracing the Suck in a Savage Little War
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 85
EP 85
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400130
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI The World's Bloodiest History: Massacre, Genocide, and the Scars Left on
Civilization
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 86
EP 86
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400138
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Hero of the Air: Glenn Curtiss and the Birth of Naval Aviation
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 86
EP 86
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400142
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Eyes in the Sky: Eisenhower, the CIA, and the Cold War
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 86
EP 86
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400141
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI The Dream Machine: The Untold History of the Notorious V-22 Osprey
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 2
U2 3
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 86
EP 86
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400143
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Islands of Hell: The US Marines in the Western Pacific, 1944-1945
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 86
EP 86
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400140
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI The Long Way Home: An American Journey from Ellis Island to the Great
War
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 86
EP 86
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400139
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI SEAL of Honor: Operation Red Wings and the Life of Lt.
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 86
EP 86
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400136
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI The Immortals: History's Fighting Elites
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 86
EP 86
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400137
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI The Untold War: Inside the Hearts, Minds, and Souls of Our Soldiers
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 87
EP 87
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400148
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Dangerous Ground: America's Failed Arms Control Policy, from FDR to
Obama
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 87
EP 87
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400146
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Waging War in Waziristan: The British Struggle in the Land of Bin Laden,
1849-1947
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
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PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 87
EP 87
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400147
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI War by Land, Sea and Air: Dwight Eisenhower and the Concept of Unified
Command
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
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PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 87
EP 87
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400145
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI Militant Islamist Ideology: The Threat to the West
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD APR 1
PY 2010
VL 135
IS 6
BP 87
EP 87
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 576KE
UT WOS:000276142400144
ER
PT J
AU Cloran, FJ
Banks, KP
Song, WS
Kim, Y
Bradley, YC
AF Cloran, Francis J.
Banks, Kevin P.
Song, Won S.
Kim, Young
Bradley, Yong C.
TI Limitations of dual time point PET in the assessment of lung nodules
with low FDG avidity
SO LUNG CANCER
LA English
DT Article
DE Dual time point; Delayed imaging; Positron emission tomography; Lung
cancer; Lung nodule; SUV
ID POSITRON-EMISSION-TOMOGRAPHY; PULMONARY NODULES; F-18-FDG PET; DIAGNOSIS
AB FDG PET has long shown efficacy in the evaluation of indeterminate pulmonary nodules. More recently, the use of dual time point imaging has been looked at as a means for improving sensitivity and accuracy. While initial reports were very promising, more recent results looking specifically at pulmonary lesions with low levels of FDG avidity demonstrated limitations. These lesions (initial maximum standard uptake value of less than 2.5) are of particular interest due to the fact that well-differentiated adenocarcinomas, broncheoaveolar carcinoma and carcinoid may have low FDG avidity on standard PET imaging, leading to false-negative exams. Our study retrospectively reviewed the accuracy of dual time point (DTP) FDG PET imaging to determine if it aided in the identification of malignant pulmonary nodules when initial time point imaging showed a maximum SUV of less than 2.5. 113 patients had undergone a total of 130 DTP PET/CT with 152 lesions assessed. 67 lesions were subsequently definitively diagnosed as benign or malignant based upon biopsy or imaging follow-up. Utilizing a maximum SUV increase of 10%, which optimizes our sensitivity and specificity; our results demonstrate a sensitivity of 63% and a specificity of 59%, similar to other investigators evaluating lesions with low FDG avidity Increasing or decreasing this threshold did not improve our results, nor did the addition of lesions with maximum SUV's of 2.5 or greater on initial imaging. Specifically in nodules with low FDG avidity (max SUV < 2.5), the sensitivity was 61%, specificity 58%, and accuracy was 60%. Our findings suggest that DTP FOG PET may not be of benefit in the assessment of pulmonary nodules with maximum SUV of less than 2.5 on initial imaging. Published by Elsevier Ireland Ltd.
C1 [Cloran, Francis J.; Banks, Kevin P.; Song, Won S.; Kim, Young; Bradley, Yong C.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA.
[Cloran, Francis J.; Kim, Young] Wilford Hall USAF Med Ctr, Dept Radiol, Lackland AFB, TX 78236 USA.
RP Banks, KP (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM kevin.banks@amedd.army.mil
NR 9
TC 34
Z9 37
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0169-5002
J9 LUNG CANCER
JI Lung Cancer
PD APR
PY 2010
VL 68
IS 1
BP 66
EP 71
DI 10.1016/j.lungcan.2009.05.013
PG 6
WC Oncology; Respiratory System
SC Oncology; Respiratory System
GA 579NN
UT WOS:000276378400010
PM 19559496
ER
PT J
AU Kenefick, RW
AF Kenefick, Robert W.
TI Energy Cost of Physical Activities in Persons with Spinal Cord
Injury-Comment
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Editorial Material
ID MEN
C1 USA, Environm Med Res Inst, Natick, MA 01760 USA.
RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA.
NR 8
TC 1
Z9 1
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD APR
PY 2010
VL 42
IS 4
BP 689
EP 690
DI 10.1249/MSS.0b013e3181bf631b
PG 2
WC Sport Sciences
SC Sport Sciences
GA 571DC
UT WOS:000275730500009
PM 21099758
ER
PT J
AU Chen, MK
Chang, YC
Yang, CE
Guo, YH
Mazurowski, J
Yin, S
Ruffin, P
Brantley, C
Edwards, E
Luo, C
AF Chen, Meng-Ku
Chang, Yun-Ching
Yang, Chia-En
Guo, Yaohui
Mazurowski, John
Yin, Stuart
Ruffin, Paul
Brantley, Christina
Edwards, Eugene
Luo, Claire
TI TUNABLE TERAHERTZ PLASMONIC LENSES BASED ON SEMICONDUCTOR MICROSLITS
SO MICROWAVE AND OPTICAL TECHNOLOGY LETTERS
LA English
DT Article
DE terahertz; plasmonics; semiconductor microslits
ID TRANSMISSION; ARRAYS
AB A theoretical investigation of tunable terahertz (THz) plasmonic lenses on the basis of InSb microslits is presented. First, it is demonstrated that the surface plasmon polaritons propagating in an InSb microslit array with variant slit widths would face different phase retardations. which. by design. can produce a focusing wavefront. The extraordinary transmission of THz radiation through the InSb subwavelength slit array is also observed. Second. a method for timing the focal lengths of InSb plasmonic lenses is proposed. The results in this article provide a potential way to realize a tunable terahertz plasmonic lens with high transmission, which can be applied to the application of rapid 3D z-scanning based THz imaging and sensing. (C) 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 979-981, 2010: Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25079
C1 [Chen, Meng-Ku; Chang, Yun-Ching; Yang, Chia-En; Guo, Yaohui; Yin, Stuart] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
[Mazurowski, John] Penn State Univ, Ctr Electroopt, University Pk, PA 16802 USA.
[Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA.
[Luo, Claire] Gen Opto Solut LLC, State Coll, PA 16803 USA.
RP Chen, MK (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
EM sxy105@psu.edu
FU Office of Naval Research
FX Partial financial support of this work by the Basic Research Program of
the Office of Naval Research is greatly appreciated.
NR 10
TC 18
Z9 18
U1 2
U2 9
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0895-2477
J9 MICROW OPT TECHN LET
JI Microw. Opt. Technol. Lett.
PD APR
PY 2010
VL 52
IS 4
BP 979
EP 981
DI 10.1002/mop.25079
PG 3
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA 569YZ
UT WOS:000275640100057
ER
PT J
AU Zacker, LL
Thompson, JC
Murray, CK
AF Zacker, Lisa L.
Thompson, Jennifer C.
Murray, Clinton K.
TI Re: Determination of the Internal Medicine Service's Role in Emergency
Department Length of Stay at a Military Medical Center. Mil Med 2009;
174: 1163-6. Response
SO MILITARY MEDICINE
LA English
DT Letter
C1 [Zacker, Lisa L.; Thompson, Jennifer C.; Murray, Clinton K.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Zacker, LL (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD APR
PY 2010
VL 175
IS 4
BP III
EP IV
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 582GQ
UT WOS:000276585100002
ER
PT J
AU Pickering, MA
Hammermeister, J
Ohson, C
Holliday, B
Ulmer, G
AF Pickering, Michael A.
Hammermeister, Jon
Ohson, Carl
Holliday, Bernie
Ulmer, Graham
TI An Exploratory Investigation of Relationships Among Mental Skills and
Resilience in Warrior Transition Unit Cadre Members
SO MILITARY MEDICINE
LA English
DT Article
ID POSITIVE EMOTIONS; STRESS; INDIVIDUALS; EXPERIENCES; ADVERSITY; HEALTH;
SCALE; BACK
AB Warrior transition unit (WTU) cadre members are exposed to a variety of stressors that put them at risk for adverse conditions and events. Resilience may be a construct capable of moderating some of these potential negative outcomes. In turn, mental toughness is a concept associated with resilience that may provide a unique framework from which to train resilient behavior. This article explored associations between resilience and several mental skills that are assumed to be related to mental toughness, in a sample (n = 27) of WTU cadre members in the U.S. Army. Instruments included the Ottawa Mental Skills Inventory (OMSAT-3) and the Resilience Scale (RS). Both cognitive mental skills and emotion management skills were positively associated with resilience. Results also indicated a model specifying emotion management as a mediator of the relationship between cognitive skills and resilience was consistent with the study data.
C1 [Pickering, Michael A.; Hammermeister, Jon; Ohson, Carl; Holliday, Bernie] W Point Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA.
[Ulmer, Graham] Univ Idaho, Coll Educ, Moscow, ID 83844 USA.
RP Pickering, MA (reprint author), W Point Mil Acad, Ctr Enhanced Performance, 745A Brewerton Rd, West Point, NY 10996 USA.
NR 42
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Z9 6
U1 2
U2 7
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD APR
PY 2010
VL 175
IS 4
BP 213
EP 219
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 582GQ
UT WOS:000276585100003
PM 20446495
ER
PT J
AU Bell, NS
Amoroso, PJ
Williams, JO
Yore, MM
Engel, CC
Senier, L
DeMattos, AC
Wegman, DH
AF Bell, Nicole S.
Amoroso, Paul J.
Williams, Jeffrey O.
Yore, Michelle M.
Engel, Charles C., Jr.
Senier, Laura
DeMattos, Annette C.
Wegman, David H.
TI Demographic, Physical, and Mental Health Factors Associated With
Deployment of US Army Soldiers to the Persian Gulf
SO MILITARY MEDICINE
LA English
DT Article
ID OPERATION-DESERT-STORM; TRAUMA-RELATED SYMPTOMS; WAR VETERANS;
POSTTRAUMATIC-STRESS; SELF-REPORTS; ALCOHOL-CONSUMPTION; MILITARY
PERSONNEL; CAGE QUESTIONNAIRE; FOLLOW-UP; MORTALITY
AB A total of 675,626 active duty Army soldiers who were known to be at risk for deployment to the Persian Gulf were followed from 1980 through the Persian Gulf War. Hospitalization histories for the entire cohort and Health Risk Appraisal surveys for a subset of 374 soldiers were used to evaluate prewar distress, health, and behaviors. Deployers were less likely to have had any prewar hospitalizations or hospitalization for a condition commonly reported among Gulf War veterans or to report experiences of depression/suicidal ideation. Deployers reported greater satisfaction with life and relationships but displayed greater tendencies toward risk taking, such as drunk driving, speeding, and failure to wear safety belts. Deployed veterans were more likely to receive hazardous duty pay and to he hospitalized for an injury than nondeployed Gulf War-era veterans. If distress is a predictor of postwar morbidity, it is likely attributable to experiences occurring during or after the war and not related to prewar exposures or health status. Postwar excess injury risk may be explained in part by a propensity for greater risk taking, which was evident before and persisted throughout the war.
C1 [Bell, Nicole S.; Williams, Jeffrey O.; Senier, Laura; DeMattos, Annette C.] SSDC Inc, Natick, MA USA.
[Amoroso, Paul J.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Yore, Michelle M.; Engel, Charles C., Jr.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA.
[Yore, Michelle M.; Engel, Charles C., Jr.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA.
[Wegman, David H.] Univ Massachusetts, Dept Work Environm, Lowell, MA USA.
RP Bell, NS (reprint author), SSDC Inc, Natick, MA USA.
FU U.S. Army Medical Research Acquisition Activity [DAMD17-98-1-8610];
National Institute on Alcohol Abuse and Alcoholism [1 R29 AA11407-01A1]
FX This study was made possible by grant DAMD17-98-1-8610 from the U.S.
Army Medical Research Acquisition Activity and by grant 1 R29
AA11407-01A1 from the National Institute on Alcohol Abuse and
Alcoholism.
NR 41
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U1 1
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD APR
PY 2010
VL 175
IS 4
BP 227
EP 237
PG 11
WC Medicine, General & Internal
SC General & Internal Medicine
GA 582GQ
UT WOS:000276585100005
PM 20446497
ER
PT J
AU Fulton, LV
Devore, RB
McMurry, PM
AF Fulton, Lawrence V.
Devore, Raymond B., Jr.
McMurry, Pat M.
TI Estimating Sustaining Base-Hospital Personnel Requirements During
Extended Operations
SO MILITARY MEDICINE
LA English
DT Article
AB This case study provides a unique method for estimating sustaining base military hospital personnel requirements during combat and stability operations while underscoring the need for such analysis before the commencement of combat operations. The requirement estimates are based on a major combat operation (MCO) scenario, which was extended to simulate stability operations. The scenario selected derived from Department of Defense strategic planning guidance as modeled by the Total Army Analysis (TAA). Since casualties experienced in combat result in additional workload for military hospitals, a mechanism for estimating that workload is required. A single scenario generated as part of an analysis for the acting Army surgeon general produced a median requirement of 1,299 additional full-time equivalents (FTEs) over the course of 36 months, highlighting a significant gap between capabilities and requirements.
C1 [Fulton, Lawrence V.; Devore, Raymond B., Jr.; McMurry, Pat M.] USA, Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, Ft Sam Houston, TX 78234 USA.
RP Fulton, LV (reprint author), USA, Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, 1608 Stanley Rd,Suite 47, Ft Sam Houston, TX 78234 USA.
NR 8
TC 2
Z9 2
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD APR
PY 2010
VL 175
IS 4
BP 238
EP 246
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA 582GQ
UT WOS:000276585100006
PM 20446498
ER
PT J
AU Weber, NS
Cowan, DN
Bedno, SA
Niebuhr, DW
AF Weber, Natalya S.
Cowan, David N.
Bedno, Sheryl A.
Niebuhr, David W.
TI Descriptive Epidemiology of Bipolar I Disorder Among United States
Military Personnel
SO MILITARY MEDICINE
LA English
DT Article
ID GENDER-DIFFERENCES; MENTAL-DISORDERS; US MILITARY; ONSET; AGE; MANIA;
COMORBIDITY; PREVALENCE; DIAGNOSIS; ETHNICITY
AB Psychiatric disorders in military members require substantial medical, administrative, and financial resources, and are among the leading causes of hospitalization and early discharge. We reviewed available data to better understand the incidence of bipolar I disorder among military personnel. Defense Medical Epidemiology Database inpatient data were used. Descriptive and comparative statistics were performed. From 1997-2006 there were 3,317 first hospitalizations for bipolar I disorder with a mean of 1.2 hospitalizations per case. The rate of first occurrence among this adult population was 0.24 per 1,000 person-years. The incidence increased over time or depressed and mixed episode types among both genders. High risk groups include women, younger individuals, and whites. This population provides insight into adult onset bipolar! disorder incidence and demographic patterns not available elsewhere and offers potential opportunities to improve its understanding.
C1 [Weber, Natalya S.; Cowan, David N.; Bedno, Sheryl A.; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, Silver Spring, MD 20910 USA.
RP Weber, NS (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
NR 37
TC 6
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U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD APR
PY 2010
VL 175
IS 4
BP 247
EP 251
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 582GQ
UT WOS:000276585100007
PM 20446499
ER
PT J
AU Platteborze, LS
Young-McCaughan, S
King-Letzkus, I
McClinton, A
Halliday, A
Jefferson, TC
AF Platteborze, Lynn S.
Young-McCaughan, Stacey
King-Letzkus, Ileana
McClinton, Annette
Halliday, Ann
Jefferson, Thomas C.
TI Performance Improvement/Research Advisory Panel: A Model for Determining
Whether a Project Is a Performance or Quality Improvement Activity or
Research
SO MILITARY MEDICINE
LA English
DT Article
AB The determination of whether an activity is performance improvement governed by The Joint Commission standards and local hospital policy or research governed by federal regulation and requiring institutional review board (IRB) review and approval can be complex, especially in academic clinical organizations. Both processes can address scientific validity, fair participant selection, favorable risk-benefit ratio, respect for participants, and independent review. In an attempt to guide staff as to whether their project needs IRB review or not, a performance improvement/research advisory panel (PIRAP) was formed to serve two military organizations. In this article, performance improvement and quality improvement is differentiated from research as much as possible, the composition and function of PIRAP is described, and guidelines for publishing findings that support the nature of the project are provided.
C1 [Platteborze, Lynn S.; McClinton, Annette] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Young-McCaughan, Stacey] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Dept Psychiat, San Antonio, TX 78229 USA.
[King-Letzkus, Ileana] Brooke Army Med Ctr, HIPAA Res Compliance, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[Halliday, Ann] Brooke Army Med Ctr, Dept Qual Serv, Ft Sam Houston, TX 78234 USA.
[Jefferson, Thomas C.] Brooke Army Med Ctr, Dept Pediat, Ft Sam Houston, TX 78234 USA.
RP Platteborze, LS (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
NR 5
TC 4
Z9 4
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD APR
PY 2010
VL 175
IS 4
BP 289
EP 291
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 582GQ
UT WOS:000276585100014
PM 20446506
ER
PT J
AU Lenart, M
Buckenmaier, CC
Kim, MJ
Plunkett, AR
AF Lenart, Mark
Buckenmaier, Chester C., III
Kim, Moon J.
Plunkett, Anthony R.
TI Development of a Complicated Pain Syndrome Following Cyanide Poisoning
in a US Soldier
SO MILITARY MEDICINE
LA English
DT Article
ID REFLEX SYMPATHETIC DYSTROPHY; PATIENT; BLOCK
AB A majority of modern war wounds are caused by blasts and high-energy ballistics. Extremity injuries predominate since modern body armor does not protect these areas due to mobility limitations. A less known and more insidious mechanism of enemy attack among our soldiers involves treachery by the local populace posing as noncombatants. One such recent event involved the contamination of tobacco with cyanide (CN(-)). We describe a case of a soldier with CN(-) intoxication due to ingestion of tobacco purchased from a local merchant. The soldier developed a complex neuropathic pain syndrome and was successfully treated with an inpatient high-dose intravenous ketamine infusion in combination with continuous peripheral nerve blockade.
C1 [Lenart, Mark; Buckenmaier, Chester C., III; Plunkett, Anthony R.] USA, Walter Reed Army Med Ctr, Reg Anaesthesia & Pain Management Initiat, Anaesthesia & Operat Serv, Washington, DC 20307 USA.
[Kim, Moon J.] Walter Reed Army Med Ctr, Dept Phys Med & Rehabil, Washington, DC 20307 USA.
RP Lenart, M (reprint author), USA, Walter Reed Army Med Ctr, Reg Anaesthesia & Pain Management Initiat, Anaesthesia & Operat Serv, Bldg 2,Ward 44,Room 4418, Washington, DC 20307 USA.
NR 15
TC 0
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD APR
PY 2010
VL 175
IS 4
BP 292
EP 294
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 582GQ
UT WOS:000276585100015
PM 20446507
ER
PT J
AU Mitchell, JL
Chatwell, N
Christensen, D
Diaper, H
Minogue, TD
Parsons, TM
Walker, B
Weller, SA
AF Mitchell, Jan L.
Chatwell, Nicola
Christensen, Deanna
Diaper, Helen
Minogue, Timothy D.
Parsons, Tanya M.
Walker, Brian
Weller, Simon A.
TI Development of real-time PCR assays for the specific detection of
Francisella tularensis ssp tularensis, holarctica and mediaasiatica
SO MOLECULAR AND CELLULAR PROBES
LA English
DT Article
DE Tularaemia; Real-time PCR; Diagnosis; Francisella tularensis
ID SUBSP TULARENSIS; IDENTIFICATION; TULAREMIA; STRAINS; SPECIMENS; AGENT
AB Real-time polymerase chain reaction (PCR) assays were developed to detect Francisella tularensis (Ft), the causative agent of tularaemia in humans. Two real-time PCRs (FTT0376 and FTT0523) were designed in genetic sequences identified by the Insignia genome comparison tool (http://insignia.cbcb.umd.edu/) as being unique to pathogenic subspecies of F tularensis. Both PCRs identified all pathogenic E tularensis subspecies but did not cross react with avirulent Francisella philomiragia or F tularensis ssp. novicida or other environmental bacteria. Limits of detection from DNA purified from pure culture (FTT0376 similar to 80 Ft genome equivalents (GEs) per PCR; FTT0523 similar to 20 Ft GEs per PCR;) and DNA purified from spiked blood samples (4 x 10(4) to 4 x 10(3) cfu ml(-1), both assays) were determined. (C) 2009 Published by Elsevier Ltd.
C1 [Mitchell, Jan L.; Chatwell, Nicola; Diaper, Helen; Parsons, Tanya M.; Walker, Brian; Weller, Simon A.] Def Sci & Technol Lab, Detect Dept, Salisbury SP4 0JQ, Wilts, England.
[Christensen, Deanna; Minogue, Timothy D.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Mitchell, JL (reprint author), Def Sci & Technol Lab, Detect Dept, Salisbury SP4 0JQ, Wilts, England.
EM jan.mitchell@salisbury.nhs.uk
FU Ministry of Defence (UK)
FX The development of the multiplex F tularensis PCR assay was funded by
the Ministry of Defence (UK). The authors wish to thank the Technical
Cooperation Program, especially Technical Panel 14 and the Detection and
Diagnostic Reagents Working Group, for facilitating the collaboration
between Dstl and USAMRIID. The UK authors would like to thank David
Norwood & Jim Jaissle (USAMRIID) for enabling access to DNA reference
panels. Opinions, interpretations, conclusions and recommendations
stated in this paper are those of the authors and are not necessarily
endorsed by the U.S. Army.
NR 22
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U1 2
U2 11
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0890-8508
J9 MOL CELL PROBE
JI Mol. Cell. Probes
PD APR
PY 2010
VL 24
IS 2
BP 72
EP 76
DI 10.1016/j.mcp.2009.10.004
PG 5
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Biotechnology & Applied Microbiology; Cell Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Cell Biology
GA 566WJ
UT WOS:000275403700003
PM 19833196
ER
PT J
AU Sharlow, ER
Grogl, M
Johnson, J
Lazo, JS
AF Sharlow, Elizabeth R.
Groegl, Max
Johnson, Jacob
Lazo, John S.
TI Anti-leishmanial Drug Discovery: Rising to the Challenges of a Highly
Neglected Disease
SO MOLECULAR INTERVENTIONS
LA English
DT Editorial Material
ID CUTANEOUS-LEISHMANIASIS; FUTURE; STRATEGIES; EFFICACY; GROWTH; BURDEN;
CELLS
C1 [Sharlow, Elizabeth R.; Lazo, John S.] Univ Pittsburgh, Drug Discovery Inst, Pittsburgh, PA 15260 USA.
[Sharlow, Elizabeth R.; Lazo, John S.] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15260 USA.
[Groegl, Max; Johnson, Jacob] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Sharlow, ER (reprint author), Univ Pittsburgh, Drug Discovery Inst, Pittsburgh, PA 15260 USA.
EM lazo@pitt.edu
NR 31
TC 6
Z9 6
U1 0
U2 4
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 1534-0384
J9 MOL INTERV
JI Mol. Interv.
PD APR
PY 2010
VL 10
IS 2
BP 72
EP 75
DI 10.1124/mi.10.2.4
PG 4
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 578QO
UT WOS:000276309200003
PM 20368366
ER
PT J
AU Hemmert, AC
Otto, TC
Wierdl, M
Edwards, CC
Fleming, CD
MacDonald, M
Cashman, JR
Potter, PM
Cerasoli, DM
Redinbo, MR
AF Hemmert, Andrew C.
Otto, Tamara C.
Wierdl, Monika
Edwards, Carol C.
Fleming, Christopher D.
MacDonald, Mary
Cashman, John R.
Potter, Philip M.
Cerasoli, Douglas M.
Redinbo, Matthew R.
TI Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent
Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin
SO MOLECULAR PHARMACOLOGY
LA English
DT Article
ID OXIME-INDUCED REACTIVATION; ORGANOPHOSPHORUS COMPOUNDS;
CRYSTAL-STRUCTURES; MAMMALIAN CARBOXYLESTERASES; HUMAN
ACETYLCHOLINESTERASE; ACTIVE-CENTER; INHIBITION; PROTECTION; SOMAN;
TOXICITY
AB Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholinergic crisis. Development of protein-based therapeutics is being pursued with the goal of preventing nerve agent toxicity and protecting against the long-term side effects of these agents. The drug-metabolizing enzyme human carboxylesterase 1 (hCE1) is a candidate protein-based therapeutic because of its similarity in structure and function to the cholinesterase targets of nerve agent poisoning. However, the ability of wild-type hCE1 to process the G-type nerve agents sarin and cyclosarin has not been determined. We report the crystal structure of hCE1 in complex with the nerve agent cyclosarin. We further use stereoselective nerve agent analogs to establish that hCE1 exhibits a 1700- and 2900-fold preference for the P R enantiomers of analogs of soman and cyclosarin, respectively, and a 5-fold preference for the P S isomer of a sarin analog. Finally, we show that for enzyme inhibited by racemic mixtures of bona fide nerve agents, hCE1 spontaneously reactivates in the presence of sarin but not soman or cyclosarin. The addition of the neutral oxime 2,3-butanedione monoxime increases the rate of reactivation of hCE1 from sarin inhibition by more than 60-fold but has no effect on reactivation with the other agents examined. Taken together, these data demonstrate that hCE1 is only reactivated after inhibition with the more toxic P S isomer of sarin. These results provide important insights toward the long-term goal of designing novel forms of hCE1 to act as protein-based therapeutics for nerve agent detoxification.
C1 [Redinbo, Matthew R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.
[Hemmert, Andrew C.; Fleming, Christopher D.; Redinbo, Matthew R.] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA.
[Otto, Tamara C.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, Baltimore, MD USA.
[MacDonald, Mary; Cashman, John R.] Human BioMol Res Inst, San Diego, CA USA.
[Wierdl, Monika; Edwards, Carol C.; Potter, Philip M.] St Jude Childrens Hosp, Dept Mol Pharmacol, Memphis, TN 38105 USA.
RP Redinbo, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA.
EM redinbo@unc.edu
RI Potter, Philip/J-4515-2013
FU National Institutes of Health National Institute of Neurological
Disorders and Stroke [NS58089]; National Institutes of Health National
Cancer Institute [CA21765]; American Lebanese Syrian Associated
Charities
FX This work was supported by the National Institutes of Health National
Institute of Neurological Disorders and Stroke [Grant NS58089]; the
National Institutes of Health National Cancer Institute [Grant CA21765];
and the American Lebanese Syrian Associated Charities.
NR 40
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U2 14
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0026-895X
J9 MOL PHARMACOL
JI Mol. Pharmacol.
PD APR
PY 2010
VL 77
IS 4
BP 508
EP 516
DI 10.1124/mol.109.062356
PG 9
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 571BZ
UT WOS:000275725600002
PM 20051531
ER
PT J
AU Brown, RS
Harnish, RA
Carter, KM
Boyd, JW
Deters, KA
Eppard, MB
AF Brown, Richard S.
Harnish, Ryan A.
Carter, Kathleen M.
Boyd, James W.
Deters, Katherine A.
Eppard, M. Brad
TI An Evaluation of the Maximum Tag Burden for Implantation of Acoustic
Transmitters in Juvenile Chinook Salmon
SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT
LA English
DT Article
ID ATLANTIC SALMON; SWIMMING PERFORMANCE; RADIO TRANSMITTERS; PREDATOR
AVOIDANCE; COLUMBIA RIVERS; SURVIVAL; TROUT; SMOLTS; GROWTH; WILD
AB A substantial percentage of the Pacific salmon Oncorhynchus spp. and steelhead O. mykiss smolts that emigrate to the ocean each year are smaller than 110 mm (fork length). However, relatively few researchers have implanted acoustic transmitters in fish of this size, and none have reported minimum fish lengths below 110 mm for which the tag burden did not negatively influence growth or survival. The influence of a surgically implanted acoustic microtransmitter and a passive integrated transponder (PIT) tag on the growth and survival of hatchery-reared juvenile Chinook salmon was examined over a period of 30 d. Growth and survival were compared between treatment (tagged) and control (untagged) fish within three size-groups (80-89, 90-99, and 100-109 mm). The acoustic microtransmitter and PIT tag implanted in our study had a combined weight of 0.74 g; the combined tag burden for implanted fish ranged from 4.5% to 15.7%. The results indicated that growth and survival among implanted juvenile Chinook salmon were size dependent. Significant differences in growth rate and survival were observed between treatment and control fish in the 80-89-mm group. The survival of implanted fish smaller than 11.1 g (tag burden, >6.7%) and the growth of fish smaller than 9.0 g (tag burden, >8.2%) were negatively affected by the implantation or presence of an acoustic microtransmitter and PIT tag. The results of this study will aid researchers in determining the minimum fish size suitable for use in acoustic telemetry studies that estimate the short-term (30-d) survival and growth of juvenile salmonids.
C1 [Brown, Richard S.; Harnish, Ryan A.; Carter, Kathleen M.; Boyd, James W.; Deters, Katherine A.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA.
[Eppard, M. Brad] US Army Corps Engineers, Portland, OR 97204 USA.
RP Brown, RS (reprint author), Pacific NW Natl Lab, Ecol Grp, POB 999, Richland, WA 99352 USA.
EM rich.brown@pnl.gov
FU U.S. Army Corps of Engineers, Portland District; U.S. Department of
Energy [DE-AC05-76RL01830]
FX This study was funded by the U.S. Army Corps of Engineers, Portland
District. The Pacific Northwest National Laboratory is operated by
Battelle for the U.S. Department of Energy under contract
DE-AC05-76RL01830. With appreciation, we acknowledge the technical
contributions to the project made by the following people from the
Pacific Northwest National Laboratory: Brian Bellgraph, Geoffrey
McMichael, Jessica Carter, David Geist, Tom Carlson, Abby Welch, Marie
Theriault, Garrett McKinney, Jennifer Panther, Katie Ovink, Katie
Murray, Gayle Dirkes, Tirell Monter, Ian Welch, Julie Miller, Brooke
Sakara, Chris Eilers, Scott Abernethy, Craig McKinstry, and Andrea
Currie. We also thank John Skalski of the University of Washington. Our
thanks go also to Brad Ryan, Eric Hockersmith, and Michelle Rub of NOAA
Fisheries.
NR 28
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U1 0
U2 12
PU AMER FISHERIES SOC
PI BETHESDA
PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA
SN 0275-5947
J9 N AM J FISH MANAGE
JI North Am. J. Fish Manage.
PD APR
PY 2010
VL 30
IS 2
BP 499
EP 505
DI 10.1577/M09-038.1
PG 7
WC Fisheries
SC Fisheries
GA 599XP
UT WOS:000277947800014
ER
PT J
AU Ter-Gabrielyan, N
Merkle, LD
Kupp, ER
Messing, GL
Dubinskii, M
AF Ter-Gabrielyan, N.
Merkle, L. D.
Kupp, E. R.
Messing, G. L.
Dubinskii, M.
TI Efficient resonantly pumped tape cast composite ceramic Er:YAG laser at
1645 nm
SO OPTICS LETTERS
LA English
DT Article
ID ND-YAG
AB Laser operation of a composite ceramic Er:YAG rod is demonstrated at 1645 nm with a slope efficiency of 56.9% under resonant pumping at 1532.3 nm. This is believed to be the first reported composite ceramic Er: YAG laser and also the first reported use of a tape cast technique for producing laser ceramics.
C1 [Ter-Gabrielyan, N.; Merkle, L. D.; Dubinskii, M.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA.
[Kupp, E. R.; Messing, G. L.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Kupp, E. R.; Messing, G. L.] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA.
RP Dubinskii, M (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM mdubinskiy@arl.army.mil
FU High Energy Laser Joint Technology Office [BAA 05-DE-01]
FX This work was partially supported by the High Energy Laser Joint
Technology Office under BAA 05-DE-01.
NR 11
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U1 2
U2 30
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
J9 OPT LETT
JI Opt. Lett.
PD APR 1
PY 2010
VL 35
IS 7
BP 922
EP 924
PG 3
WC Optics
SC Optics
GA 578QP
UT WOS:000276309300010
PM 20364170
ER
PT J
AU Bulatov, D
Lavery, JE
AF Bulatov, Dimitri
Lavery, John E.
TI Reconstruction and Texturing of 3D Urban Terrain from Uncalibrated
Monocular Images Using L-1 Splines
SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING
LA English
DT Article
ID SURFACE RECONSTRUCTION
AB We propose a five-step procedure for reconstruction and texturing of 3D urban terrain based on a novel approach for 3D surface reconstruction from optical images produced by monocular optical cameras on small, inexpensive vehicles without external referencing. The approach consists of generation of a nonparametric 2.5D L-1-spline surface from a point cloud and iterative creation of parametric 3D L-1-spline surfaces based on parametrizations using the previous surface. Computational results for a model house and for Gottesaue Palace in Karlsruhe, Germany are presented. The results presented here are proof of principle results that show that the L-1-spline-based procedure is able to reconstruct and texture 3D urban terrain in spite of the large, abrupt changes in density of the point cloud, and that it produces results that are visually competitive with or superior to competing procedures. Future improvements (finer grids, adaptive grids and parameters, reduction of computing time) are outlined.
C1 [Bulatov, Dimitri; Lavery, John E.] FOM, FGAN, Res Inst Optron & Pattern Recognit, Scene Anal Div, D-76275 Ettlingen, Germany.
[Lavery, John E.] USA, Res Lab, Army Res Off, Div Math, Res Triangle Pk, NC 27709 USA.
RP Bulatov, D (reprint author), FOM, FGAN, Res Inst Optron & Pattern Recognit, Scene Anal Div, Gutleuthausstr 1, D-76275 Ettlingen, Germany.
EM bulatov@fom.fgan.de
NR 32
TC 9
Z9 9
U1 0
U2 1
PU AMER SOC PHOTOGRAMMETRY
PI BETHESDA
PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA
SN 0099-1112
EI 2374-8079
J9 PHOTOGRAMM ENG REM S
JI Photogramm. Eng. Remote Sens.
PD APR
PY 2010
VL 76
IS 4
BP 439
EP 449
PG 11
WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing;
Imaging Science & Photographic Technology
SC Physical Geography; Geology; Remote Sensing; Imaging Science &
Photographic Technology
GA 577NZ
UT WOS:000276231900011
ER
PT J
AU Litz, MS
Merkel, G
Pereira, NR
Boyer, CN
Holland, GE
Schumer, JW
Seely, JF
Hudson, LT
Carroll, JJ
AF Litz, M. S.
Merkel, G.
Pereira, N. R.
Boyer, C. N.
Holland, G. E.
Schumer, J. W.
Seely, J. F.
Hudson, L. T.
Carroll, J. J.
TI Anomalous fluorescence line intensity in megavoltage bremsstrahlung
SO PHYSICS OF PLASMAS
LA English
DT Article
DE bremsstrahlung; fluorescence; plasma diagnostics; tungsten
ID KEV ENERGY-RANGE; RAY; ELEMENTS
AB An anomalous ratio between K alpha and K beta fluorescence interpreted with plasma radiation modeling can be a useful diagnostic in laser-produced plasmas. In cold tungsten there exists a similar but as yet undocumented anomaly: for 2 MeV end point bremsstrahlung in the forward direction K beta/K alpha(1)similar or equal to 1, while this ratio is closer to 0.5 for bremsstrahlung in reflection and for an isolated atom. As in the laser-produced plasma, the anomalous ratio reflects a localized source of fluorescence inside the material combined with differential attenuation of the fluorescence photons on their way out. To measure the similar or equal to 60 keV fluorescence lines, a Cauchois transmission crystal spectrograph that works well for laser-produced plasmas must suppress the intense bremsstrahlung that accompanies the fluorescence, by beefing up marginal shielding and avoiding extraneous scatter sources.
C1 [Litz, M. S.; Merkel, G.] USA, Res Lab, Adelphi, MD 20873 USA.
[Pereira, N. R.] Ecopulse Inc, Springfield, VA 22150 USA.
[Boyer, C. N.] L3 Commun, Washington, DC 20375 USA.
[Holland, G. E.; Hudson, L. T.] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA.
[Schumer, J. W.; Seely, J. F.] USN, Res Lab, Washington, DC 20375 USA.
[Carroll, J. J.] Youngstown State Univ, Youngstown, OH 44555 USA.
RP Litz, MS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20873 USA.
EM pereira@speakeasy.net
RI Schumer, Joseph/D-7591-2013
FU Army Research Laboratory [W911QX07C0002]; DTRA's Basic Research Sciences
[MIPR 08-2468, MIPR 09-2156]; Naval Research Laboratory
FX This work was supported by the Army Research Laboratory, Ecopulse's
Contract No. W911QX07C0002, and by DTRA's Basic Research Sciences
Contract Nos. MIPR 08-2468 and MIPR 09-2156 with the Naval Research
Laboratory. N.R.P. thanks R. Kensek (SNL) for discussions about ITS.
NR 20
TC 5
Z9 5
U1 0
U2 1
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 1070-664X
J9 PHYS PLASMAS
JI Phys. Plasmas
PD APR
PY 2010
VL 17
IS 4
AR 043302
DI 10.1063/1.3389226
PG 8
WC Physics, Fluids & Plasmas
SC Physics
GA 590QV
UT WOS:000277243000058
ER
PT J
AU Naumann, JC
Anderson, JE
Young, DR
AF Naumann, J. C.
Anderson, J. E.
Young, D. R.
TI Remote detection of plant physiological responses to TNT soil
contamination
SO PLANT AND SOIL
LA English
DT Article
DE Trinitrotoluene; Hyperspectral reflectance; Chlorophyll fluorescence;
Photosynthesis
ID LEAF CHLOROPHYLL FLUORESCENCE; 2,4,6-TRINITROTOLUENE TNT; HYPERSPECTRAL
IMAGERY; MYRICA-CERIFERA; SALINITY STRESS; WATER-STRESS; REFLECTANCE;
VEGETATION; INDEXES; TREES
AB Our study was aimed at understanding physiological responses to trinitrotoluene (TNT) soil contamination, and using optical methods to detect TNT-induced stress in a woody plant prior to visible changes. Myrica cerifera plants were potted in soil concentrations of TNT ranging from 30-500 mg kg(-1). Physiological measurements were significantly affected by TNT exposure at all treatment levels, and photosynthetic decline likely resulted from metabolic impairment rather than stomatal closure as the experiment progressed. Several reflectance indices were able to detect TNT-induced stress before any changes in chlorophyll concentrations occurred. The most sensitive index was the simple ratio R(761)/R(757) which is linked to fluorescence in-filling of the 0(2) atmospheric absorption. Changes at R(740)/R(850) and R(735)/R(850) may be attributed to both fluorescence and structural characteristics of leaf anatomy in the near infrared region. This could have been influenced by transformation and conjugation of TNT metabolites with other compounds. chlorophyll index (CHL) or in the water band index (WBI(970)), which are indices typically associated with drought stress, and may provide a means of separating stress due to explosives. Further studies need to be conducted with a combination of stressors (TNT and natural) to determine if responses are in fact generalized or if any of these changes are separable from natural stress.
C1 [Naumann, J. C.; Anderson, J. E.] USA, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA.
[Young, D. R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
RP Naumann, JC (reprint author), USA, Erdc, Fluorescence Spect Lab, 7701 Telegraph Rd, Alexandria, VA 22315 USA.
EM jczinner@vcu.edu
FU United States Army Research Office; U.S. Department of Energy; ERDC
FX This research was support by a grant to DRY from the United States Army
Research Office. Spencer Bissett, Steven Brantley and Kati Rubis
provided support with spectral reflectance collection and data
processing. This research was also supported in part by an appointment
for JCN to the Postgraduate Research Participation Program at the U.S.
Army Corps of Engineers/Engineer Research and Development Center (ERDC)
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and ERDC.
NR 39
TC 10
Z9 10
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0032-079X
J9 PLANT SOIL
JI Plant Soil
PD APR
PY 2010
VL 329
IS 1-2
BP 239
EP 248
DI 10.1007/s11104-009-0148-1
PG 10
WC Agronomy; Plant Sciences; Soil Science
SC Agriculture; Plant Sciences
GA 568SP
UT WOS:000275543300018
ER
PT J
AU Mabry, RL
Edens, JW
Pearse, L
Kelly, JF
Harke, H
AF Mabry, Robert L.
Edens, Jason W.
Pearse, Lisa
Kelly, Joseph F.
Harke, Howard
TI Fatal Airway Injuries during Operation Enduring Freedom and Operation
Iraqi Freedom
SO PREHOSPITAL EMERGENCY CARE
LA English
DT Article
DE airway; tactical; cricothyroidotomy; Operation Iraqi Freedom; Operation
Enduring Freedom; Iraq War; combat
ID COMBAT CASUALTY CARE; MAJOR LIMB TRAUMA; SURGICAL CRICOTHYROTOMY;
HEMORRHAGE CONTROL; TOURNIQUET USE; UNITED-STATES; DEATH;
CRICOTHYROIDOTOMY; MANAGEMENT; SURVIVAL
AB Introduction. Airway compromise is the third leading cause of potentially preventable death on the battlefield. An understanding of the injuries associated with fatal airway compromise is necessary to develop improvements in equipment, training, and prehospital management strategies in order to maximize survival. Objective. To determine injury patters resulting in airway compromise in the combat setting. Methods. This was a subgroup analysis of cases previously examined by Kelly and colleagues, who reviewed autopsies of military personnel who died in combat in Iraq and Afghanistan between 2003 and 2006. Casualties with potentially survivable (PS) injuries and deaths related to airway compromise previously identified by Kelly et al. were reviewed in depth by a second panel of military physicians. Results. There were 982 cases that met the inclusion criteria. Of these, 232 cases had PS injuries. Eighteen (1.8%) cases were found to have airway compromise as the likely cause of primary death. All had penetrating injuries to the face or neck. Twelve deaths (67%) were caused by gunshot wounds, while six deaths (33%) were caused by explosions. Nine cases had concomitant injury to major vascular structures, and eight had significant airway hemorrhage. Cricothyroidotomy was attempted in five cases; all were unsuccessful. Conclusion. Airway compromise from battlefield trauma results in a small number of PS fatalities. Penetrating trauma to the face or neck may be accompanied by significant hemorrhage, severe and multiple facial fractures, and airway disruption, leading to death from airway compromise. Cricothyroidotomy may be required to salvage these patients, but the procedure failed in all instances in this series of cases. Further studies are warranted to determine the appropriate algorithm of airway management in combat casualties sustaining traumatic airway injuries.
C1 [Mabry, Robert L.] USA, Dept Combat Med Training, ATTN MCCS HW, Ft Sam Houston, TX 78114 USA.
[Edens, Jason W.; Kelly, Joseph F.] USA, Inst Surg Res, Ft Sam Houston, TX 78114 USA.
[Pearse, Lisa; Harke, Howard] Off Armed Forces Med Examiner, Rockville, MD USA.
RP Mabry, RL (reprint author), USA, Dept Combat Med Training, ATTN MCCS HW, 3151 WW White, Ft Sam Houston, TX 78114 USA.
EM robert.mabry@us.army.mil
NR 23
TC 19
Z9 20
U1 0
U2 2
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1090-3127
J9 PREHOSP EMERG CARE
JI Prehosp. Emerg. Care
PD APR-JUN
PY 2010
VL 14
IS 2
BP 272
EP 277
DI 10.3109/10903120903537205
PG 6
WC Emergency Medicine; Public, Environmental & Occupational Health
SC Emergency Medicine; Public, Environmental & Occupational Health
GA 563SW
UT WOS:000275155100021
PM 20199236
ER
PT J
AU Gao, XG
Ray, R
Xiao, Y
Ishida, K
Ray, P
AF Gao, Xiugong
Ray, Radharaman
Xiao, Yan
Ishida, Keiko
Ray, Prabhati
TI Macrolide antibiotics improve chemotactic and phagocytic capacity as
well as reduce inflammation in sulfur mustard-exposed monocytes
SO PULMONARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
DE Macrolide antibiotic; Chemotaxis; Phagocytosis; Inflammation; Sulfur
mustard; Monocyte
ID OBSTRUCTIVE PULMONARY-DISEASE; NORMAL HUMAN KERATINOCYTES; AIRWAY
EPITHELIAL-CELLS; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; ALVEOLAR
MACROPHAGES; CYTOKINE RELEASE; MOUSE SKIN; AZITHROMYCIN; EXPRESSION
AB Background: Sulfur mustard (SM) inhalation causes apoptosis and death of airway epithelial cells as well as inflammation in the airway. Efficient clearance of the cell debris by alveolar macrophages is necessitated to reduce the inflammation. Macrolide antibiotics have been reported to have anti-inflammatory properties by modulating the production of proinflammatory cytokines and mediators, and by improving macrophage functions. The present study investigated the effects of four commonly used macrolide antibiotics, namely azithromycin, clarithromycin, erythromycin, and roxithromycin, on chemotactic and phagocytotic function and on inflammatory cytokines/mediators production in vitro in SM-exposed monocyte THP-1 cells.
Results: Chemotaxis and phagocytosis of the monocytes reduced upon exposure to 10 mu M SM (8.1% and 17.5%, respectively) were restored by treatment with 10 mu M of any of the four macrolides. Overexpression of inflammatory cytokines following SM exposure was decreased by 50-70% with macrolide treatment. Similarly, exaggerated iNOS expression and nitric oxide (NO) production induced by SM exposure was largely inhibited by treatment with macrolides.
Conclusion: The data demonstrate that macrolide antibiotics were effective in improving the degenerated chemotactic and phagocytotic functions of monocytes following SM exposure, and in reducing SM-induced overproduction of proinflammatory cytokines and mediators. Thus, treatment with macrolide antibiotics may lead to improved clearance of apoptotic material in the airway and ultimately result in reduced airway inflammation and injury caused by SM inhalation, suggesting that macrolide antibiotics may serve as potential vesicant respiratory therapeutics. Published by Elsevier Ltd.
C1 [Gao, Xiugong; Ishida, Keiko; Ray, Prabhati] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
[Ray, Radharaman] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA.
[Xiao, Yan] Natl Inst Stand & Technol, Div Biochem Sci, Gaithersburg, MD 20899 USA.
RP Ray, P (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM xiugong.gao@amedd.army.mil; radharaman.ray@amedd.army.mil;
yan.xiao@nist.gov; keikoishida71@yahoo.com; prabhati.ray@amedd.army.mil
FU Defense Threat Reduction Agency [3.F0003_05_WR_C]
FX This work was supported by the Defense Threat Reduction Agency (DTRA)
Project No. 3.F0003_05_WR_C. We thank Dr. Hiroshi Ishida (Walter Reed
Army Institute of Research) for helpful discussions and Dr. Peter E.
Barker (National Institute of Standards and Technology) for advice on
immunocytochemical study. We also thank Ms. Betty Benton (US Army
Medical Research Institute of Chemical Defense) for technical assistance
with sulfur mustard exposure. The opinions or assertions contained
herein are the private views of the authors and are not to be construed
as official or as reflecting true views of the US Army or the Department
of Defense. Certain commercial equipment or materials are identified in
this paper in order to specify adequately the experimental procedures.
Such identification does not imply recommendation or endorsement by the
National Institute of Standards and Technology, nor does it imply that
the materials or equipment identified are necessarily the best available
for the purpose.
NR 51
TC 28
Z9 29
U1 0
U2 0
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1094-5539
J9 PULM PHARMACOL THER
JI Pulm. Pharmacol. Ther.
PD APR
PY 2010
VL 23
IS 2
BP 97
EP 106
DI 10.1016/j.pupt.2009.10.010
PG 10
WC Pharmacology & Pharmacy; Respiratory System
SC Pharmacology & Pharmacy; Respiratory System
GA 566FY
UT WOS:000275356700005
PM 19895898
ER
PT J
AU Deng, ZQ
Weiland, M
Carlson, T
Eppard, MB
AF Deng, Zhiqun
Weiland, Mark
Carlson, Thomas
Eppard, M. Brad
TI Design and Instrumentation of a Measurement and Calibration System for
an Acoustic Telemetry System
SO SENSORS
LA English
DT Article
DE underwater transducers; piezoelectric sensors; acoustic telemetry
AB The Juvenile Salmon Acoustic Telemetry System (JSATS) is an active sensing technology developed by the U. S. Army Corps of Engineers, Portland District, for detecting and tracking small fish. It is used primarily for evaluating behavior and survival of juvenile salmonids migrating through the Federal Columbia River Power System to the Pacific Ocean. It provides critical data for salmon protection and development of more "fishfriendly" hydroelectric facilities. The objective of this study was to design and build a Measurement and Calibration System (MCS) for evaluating the JSATS components, because the JSATS requires comprehensive acceptance and performance testing in a controlled environment before it is deployed in the field. The MCS consists of a reference transducer, a water test tank lined with anechoic material, a motion control unit, a reference receiver, a signal conditioner and amplifier unit, a data acquisition board, MATLAB control and analysis interface, and a computer. The fully integrated MCS has been evaluated successfully at various simulated distances and using different encoded signals at frequencies within the bandwidth of the JSATS transmitter. The MCS provides accurate acoustic mapping capability in a controlled environment and automates the process that allows real-time measurements and evaluation of the piezoelectric transducers, sensors, or the acoustic fields. The MCS has been in use since 2009 for acceptance and performance testing of, and further improvements to, the JSATS.
C1 [Deng, Zhiqun; Weiland, Mark; Carlson, Thomas] Pacific NW Natl Lab, Richland, WA 99332 USA.
[Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97208 USA.
RP Deng, ZQ (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99332 USA.
EM zhiqun.deng@pnl.gov; Mark.Weiland@pnl.gov; thomas.carlson@pnl.gov;
Matthew.B.Eppard@usace.army.mil
RI Deng, Daniel/A-9536-2011
OI Deng, Daniel/0000-0002-8300-8766
FU U.S. Army Corps of Engineers, Portland District
FX The work described in this article was conducted at Pacific Northwest
National Laboratory (PNNL) in Richland, Washington, which is operated by
Battelle for the U. S. Department of Energy. The authors thank Eric
Choi, Brian LaMarche, Geoff McMichael, Brian Noland, and Tom Seim of
PNNL for their help with this study. Andrea Currie, Jayson Martinez, and
Tao Fu of PNNL provided comments and technical help preparing the
manuscript. This study was funded by the U.S. Army Corps of Engineers,
Portland District.
NR 11
TC 19
Z9 19
U1 0
U2 7
PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
PI BASEL
PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND
SN 1424-8220
J9 SENSORS-BASEL
JI Sensors
PD APR
PY 2010
VL 10
IS 4
BP 3090
EP 3099
DI 10.3390/s100403090
PG 10
WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
SC Chemistry; Electrochemistry; Instruments & Instrumentation
GA 589OI
UT WOS:000277159700032
PM 22319288
ER
PT J
AU Currano, LJ
Yu, M
Balachandran, B
AF Currano, Luke J.
Yu, Miao
Balachandran, Balakumar
TI Latching in a MEMS shock sensor: Modeling and experiments
SO SENSORS AND ACTUATORS A-PHYSICAL
LA English
DT Article
DE Shock sensor; Acceleration switch; Threshold; Latching; Reduced-order
model; Inertial switch
AB Modeling, numerical, and experimental efforts undertaken to develop a fundamental understanding of latching in a MEMS shock sensor are presented. A two degree-of-freedom model is developed and numerical studies are conducted with this model. These studies, which help shed light on difficult to observe experimental aspects, are used to examine the interaction forces between the shock sensor mass and latch, bounce effects, and loss of contact between the mass and the latch. High-speed video images of the shock sensor motions collected during a latching event are shown, and these results are used to verify the model predictions. Parametric studies conducted to examine the sensitivity of the design to friction and the effects of the latch mass and stiffness properties on the latch bounce are presented and discussed. Published by Elsevier B.V.
C1 [Currano, Luke J.] USA, Res Lab, RDRL SER L, Adelphi, MD 20783 USA.
[Currano, Luke J.; Yu, Miao; Balachandran, Balakumar] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA.
RP Currano, LJ (reprint author), USA, Res Lab, RDRL SER L, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM luke.currano@us.army.mil
RI Yu, Miao/M-6252-2013
OI Yu, Miao/0000-0003-4180-5094
NR 15
TC 28
Z9 31
U1 0
U2 9
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0924-4247
J9 SENSOR ACTUAT A-PHYS
JI Sens. Actuator A-Phys.
PD APR
PY 2010
VL 159
IS 1
BP 41
EP 50
DI 10.1016/j.sna.2010.02.008
PG 10
WC Engineering, Electrical & Electronic; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA 596CP
UT WOS:000277661800006
ER
PT J
AU Batchinsky, AI
Jordan, BS
Necsoiu, C
Dubick, MA
Cancio, LC
AF Batchinsky, Andriy I.
Jordan, Bryan S.
Necsoiu, Corina
Dubick, Michael A.
Cancio, Leopoldo C.
TI DYNAMIC CHANGES IN SHUNT AND VENTILATION-PERFUSION MISMATCH FOLLOWING
EXPERIMENTAL PULMONARY CONTUSION
SO SHOCK
LA English
DT Article
DE Pulmonary contusion; true shunt; multiple inert gas elimination
technique; computed tomography
ID RESPIRATORY-DISTRESS-SYNDROME; VITRO THROMBELASTOGRAPHY MEASUREMENTS;
DILUTIONAL HYPOTHERMIC COAGULOPATHY; LIFE-THREATENING COAGULOPATHY;
TRAUMA PATIENT HYPOTHERMIA; VIVO BLEEDING-TIME; COMBAT CASUALTIES;
INHALATION INJURY; PROTHROMBIN TIME; GAS-EXCHANGE
AB The objective of this study was to investigate early changes in oxygenation by means of the multiple inert gas elimination technique and in coagulation by means of thromboelastography (TEG) after right-sided pulmonary contusion (PC) in swine. Anesthetized swine (group 1; n = 8) sustained a right-chest PC by a captive-bolt stunner. Multiple inert gas elimination technique, TEG, and thoracic computed tomography (CT) scans were performed before and 10, 30, 60, and 120 min after injury. Three-dimensional CT scan reconstruction enabled measurement of volumes of poorly (Vol(Poor)) and nonaerated (Vol(Non)) lung. Eight animals (group 0) were used as uninjured controls. Pulmonary contusion led to sustained tachycardia and transient hypotension. Partial pressure of arterial oxygen (PaO(2)) decreased from 83.9 +/- 4.2 mmHg at baseline to 51.3 +/- 2.8 mmHg 10 min after PC (P < 0.001). Vol(Poor) and Vol(Non) on the right increased significantly after PC, followed by gradual progression in injury marked by decreased Vol(Poor) and increased Vol(Non). By the multiple inert gas elimination technique, blood flow to the true shunt compartment increased from 4.4% +/- 1.0% at baseline to 21.2% +/- 4.9% 10 min after PC, P < 0.001, peaked at 33.2% +/- 7.5% 30 min after PC, P < 0.001, and remained significantly higher compared with controls. Transient increase in blood flow to low and very low ventilation-perfusion (V/Q) compartments was also seen. Clot reaction time and formation rate by TEG increased at 2 h after PC. True shunt is the major cause of hypoxemia after PC, but V/Q mismatch also contributes significantly early after injury. By CT, PC leads to significant loss of functional lung volume on the side of injury. A mild hypocoagulable state was identified 2 h after injury.
C1 [Batchinsky, Andriy I.; Jordan, Bryan S.; Necsoiu, Corina; Dubick, Michael A.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Batchinsky, AI (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA.
EM andriy.batchinsky@amedd.army.mil
RI Necsoiu, Corina/A-6255-2013
FU Combat Casualty Care Research Program; Telemedicine and Advanced
Technology Research Center, US Army Medical Research and Materiel
Command
FX Funded by the Combat Casualty Care Research Program and the Telemedicine
and Advanced Technology Research Center, US Army Medical Research and
Materiel Command.
NR 34
TC 11
Z9 11
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1073-2322
J9 SHOCK
JI Shock
PD APR
PY 2010
VL 33
IS 4
BP 419
EP 425
DI 10.1097/SHK.0b013e3181b8bcd9
PG 7
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA 575BG
UT WOS:000276037700013
PM 20407408
ER
PT J
AU Loffredo, E
Palazzo, AJ
Senesi, N
Clapp, CE
Bashore, TL
AF Loffredo, Elisabetta
Palazzo, Antonio J.
Senesi, Nicola
Clapp, C. Edward
Bashore, Terry L.
TI Germination and Early Growth of Slickspot Peppergrass (Lepidium
papilliferum) as Affected by Desert Soil Humic Acids
SO SOIL SCIENCE
LA English
DT Article
DE Slickspot peppergrass; soil humic acids; germination; early growth
ID BRASSICACEAE
AB Slickspot peppergrass (Lepidium papilliferum) is a biennial, or possibly perennial, endemic plant growing in the Southern Idaho high desert in visually distinct small-scale depressions in soils that collect water (so-called slickspots). Lepidium papilliferum establishes seed banks not germinating the first year but remaining dormant and viable for several years. Humic acids (HA) are universally considered to be the most important, abundant, and biologically and chemically active fractions of soil organic matter and are known to affect plant growth by various mechanisms, depending on their origin, nature, and concentration. The effects of HA in slickspot soils and how they relate to the possibility of being a factor in restoring native plants is only partially known. Thus, the objective of this study was to identify and evaluate the effects of HA isolated from three different layers within the soil pro. le (silt, vesicular, and clay) from inside a representative slickspot on the germination and early growth of slickspot peppergrass. Furthermore, these effects were tentatively related to the chemical, physicochemical, compositional, structural, and functional characteristics of the HA. Results of statistical analysis showed that both the type and concentration of the three HA examined exert a highly significant or significant effect on the germination and early growth of slickspot peppergrass as a function of the soil depth from which the HA originated in the slickspot. In particular, germination seemed to be enhanced, especially at higher concentrations, by the less hydrophobic HA, rich in oxygen and total sugars, present in the bottom clay soil layer, whereas root growth and shoot growth were positively influenced by the more hydrophobic and probably more polycondensed HA, rich in C, H, N, and phenolic OH present in the top layer rich in silt.
C1 [Loffredo, Elisabetta; Senesi, Nicola] Univ Bari, Dipartimento Biol & Chim Agroforestale & Ambienta, I-70126 Bari, Italy.
[Palazzo, Antonio J.] ERDC CRREL, Hanover, NH USA.
[Clapp, C. Edward] USDA ARS, St Paul, MN USA.
[Clapp, C. Edward] Univ Minnesota, St Paul, MN 55108 USA.
[Bashore, Terry L.] Airfield Operat Div, HQ ACC A3A, Langley AFB, VA USA.
RP Loffredo, E (reprint author), Univ Bari, Dipartimento Biol & Chim Agroforestale & Ambienta, I-70126 Bari, Italy.
EM loffredo@agr.uniba.it
OI Loffredo, Elisabetta/0000-0003-0783-5193
FU U.S. Army European Research Office, London, England [N62558-03-M-0010];
USACE Engineer Research and Development Center (ERDD) [A896]
FX This work was supported by the Research Contract No. N62558-03-M-0010 of
the U.S. Army European Research Office, London, England. The authors
acknowledge the funding support from the USACE Engineer Research and
Development Center (ERDD) A896 RDT&E program in the project entitled
Influence of Seedbanks on the Emergence of Buried Seeds to Predict
Future Populations of Invasive and Endangered Species under the
Habitat-Centric Species at Risk (SAR) Research to Avoid Future Training
Restrictions work package. This work is part of a study on Recovery and
Management of Slickspot Peppergrass (Lepidium papilliferum) at the Air
Force Juniper Butte Training Range, ID, Classification, Seed Viability,
and the Role of Slickspots, funded by the Airspace, Ranges, and Air
field Operations Division, HQ Air Combat Command, Langley AFB, VA. The
opinions and conclusions in this article are those of the authors and do
not necessarily reject those of the U. S. Air Force, United States Army,
or the federal government.
NR 20
TC 4
Z9 4
U1 3
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0038-075X
J9 SOIL SCI
JI Soil Sci.
PD APR
PY 2010
VL 175
IS 4
BP 186
EP 193
DI 10.1097/SS.0b013e3181d9942e
PG 8
WC Soil Science
SC Agriculture
GA 587WT
UT WOS:000277027400005
ER
PT J
AU Cohen, SP
Kapoor, SG
Nguyen, C
Anderson-Barnes, VC
Brown, C
Schiffer, D
Turabi, A
Plunkett, A
AF Cohen, Steven P.
Kapoor, Shruti G.
Nguyen, Cuong
Anderson-Barnes, Victoria C.
Brown, Charlie
Schiffer, Dominique
Turabi, Ali
Plunkett, Anthony
TI Neck Pain During Combat Operations An Epidemiological Study Analyzing
Clinical and Prognostic Factors
SO SPINE
LA English
DT Article
DE combat; military; neck pain; outcome predictor; war
ID 2000-2010 TASK-FORCE; RISK-FACTORS; BACK-PAIN; GENERAL-POPULATION;
OFFICE WORKERS; IRAQI FREEDOM; DISORDERS; RETURN; DETERMINANTS;
PREVALENCE
AB Study Design. Prospective observational study among soldiers medically evacuated out of theaters of combat operations for neck pain, with retrospective analysis of variables associated with return-to-duty.
Objectives. To provide an epidemiological overview of the burden of neck pain in deployed soldiers involved in combat operations and to identify factors associated with return-to-duty.
Summary of Background Data. Neck pain represents one of the leading causes of medical evacuation out of theaters of combat operations. Yet when compared to other diagnostic categories, treatment outcomes, militarily defined as returning a soldier to duty, remain appallingly low.
Methods. Demographic, military-specific, and outcome data were prospectively collected over a 2-week period at the Deployed Warrior Medical Management Center in Germany on 374 consecutive soldiers medically evacuated out of theaters of combat operations for a primary diagnosis pertaining to neck pain between 2004 and 2007. The 2-week period represents the maximal allowable time an evacuated soldier can spend in treatment before disposition (i.e., return to theater or evacuate to United States) is rendered. Electronic medical records were reviewed to examine the effect the following variables had on the categorical outcome measure, return-to-unit: age, gender, service-affiliation, rank and seniority, smoking history, coexisting psychiatric diagnosis, prior neck pain, mechanism of injury, whether or not the injury was combat-related, presence of headache, quality of symptoms, correlation with radiologic imaging, and referral to pain specialist.
Results. Only 14% of service members returned to their units. Significant correlations were found between female gender and non-army service affiliation, and a service member returning to their unit. Weak trends toward returning to duty were noted for nonsmokers, absence of prior neck pain, concomitant psychiatric diagnosis, corresponding complaints of headache, and referral to a pain specialist.
Conclusion. The treatment of service members medically evacuated for neck pain at the main receiving center, the level IV military treatment facility in Landstuhl, Germany, is associated with a low return-to-unit rate. Future studies should consider whether treating personnel predisposed towards a positive outcome with the limited resources available can improve return-to-duty rates.
C1 [Cohen, Steven P.; Kapoor, Shruti G.; Brown, Charlie] Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD USA.
[Cohen, Steven P.; Turabi, Ali; Plunkett, Anthony] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
[Nguyen, Cuong] Landstuhl Reg Med Ctr, Phys Med & Rehabil Serv, Dept Surg, Landstuhl, Germany.
[Anderson-Barnes, Victoria C.] Walter Reed Army Med Ctr, Dept Orthoped Surg & Rehabil, Washington, DC 20307 USA.
[Schiffer, Dominique] Univ Colorado, Sch Med, Dept Anesthesiol, Denver, CO USA.
RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21029 USA.
EM scohen40@jhmi.edu
FU John P. Murtha Neuro-science and Pain Institute, Johnstown, PA; US Army;
Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC
FX Supported by a Congressional Grant from the John P. Murtha Neuro-science
and Pain Institute, Johnstown, PA; the US Army; and the Army Regional
Anesthesia & Pain Medicine Initiative, Washington, DC.
NR 22
TC 10
Z9 10
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-2436
J9 SPINE
JI SPINE
PD APR 1
PY 2010
VL 35
IS 7
BP 758
EP 763
DI 10.1097/BRS.0b013e3181bb11a8
PG 6
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 585NV
UT WOS:000276833500007
PM 20228712
ER
PT J
AU Kashani, MD
Eliasson, AH
Hoffman, JA
Vernalis, MN
AF Kashani, Mariam D.
Eliasson, Arn H.
Hoffman, Jacqueline A.
Vernalis, Marina N.
TI Assessing Perceived Stress Provides Targets for Stroke Prevention
SO STROKE
LA English
DT Meeting Abstract
CT International Stroke Conference
CY FEB 23-26, 2010
CL San Antonio, TX
SP Amer Heart Assoc, Amer Stroke Assoc
C1 [Kashani, Mariam D.; Eliasson, Arn H.; Hoffman, Jacqueline A.; Vernalis, Marina N.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0039-2499
J9 STROKE
JI Stroke
PD APR
PY 2010
VL 41
IS 4
BP E292
EP E292
PG 1
WC Clinical Neurology; Peripheral Vascular Disease
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA 575XU
UT WOS:000276106100397
ER
PT J
AU Natesan, S
Baer, DG
Walters, TJ
Babu, M
Christy, RJ
AF Natesan, Shanmugasundaram
Baer, David G.
Walters, Thomas J.
Babu, Mary
Christy, Robert J.
TI Adipose-Derived Stem Cell Delivery into Collagen Gels Using Chitosan
Microspheres
SO TISSUE ENGINEERING PART A
LA English
DT Article
ID HUMAN BONE-MARROW; REGENERATIVE MEDICINE; IN-VITRO; STROMAL CELLS;
TISSUE REPAIR; LINEAGE CELLS; DIFFERENTIATION; VIVO; SCAFFOLD; THERAPY
AB Integration of stem cells to injured tissues requires an appropriate delivery device and scaffolding system. In the present study we have developed an in vitro strategy to load and release adipose-derived mesenchymal stem cells (ASC) from chitosan microspheres (CSM) into a collagen gel scaffold. Porous CSM of uniform size and composition were prepared and used as a stem cell carrier. ASC were allowed to attach to the microspheres and infiltrate through the microsphere pores. The number of viable cells was counted in vitro, using MTT and Calcein acetoxymethyl ester ( AM) assays, and it showed a proportional increase with seeding density and reached a maximum cell number by 24 h. The cells inside the microspheres remained metabolically active and viable, could be retrieved from the spheres, and maintained expression of stem-cell-specific markers. Electron microscopic evaluation of the cell-microsphere complex showed that the CSM were able to support cell attachment and that the cells had infiltrated into the pores of the microspheres. The ability of the cells to proliferate and differentiate into adipogenic- and osteogenic-like precursors indicates that the cells have maintained their multipotency after migration out of the microspheres. To mimic cell delivery into a tissue, ASC-loaded CSM were embedded in type-1 collagen scaffold by mixing them with type-1 collagen solution while inducing gelation. By 14 days the cells released into the collagen gel and were able to populate the entire scaffold. When observed through transmission electron microscopy, the cells align along the collagen fibrils with a characteristic fibroblast-like morphology. This study provides a model to capture pluripotent stem cells, expand their cell number within a biomaterial scaffold in vitro, and deliver within an appropriate matrix to repair damaged tissue.
C1 [Natesan, Shanmugasundaram; Baer, David G.; Walters, Thomas J.; Christy, Robert J.] USA, Inst Surg Res, Regenerat Med Res Program, Ft Sam Houston, TX 78234 USA.
[Babu, Mary] Cent Leather Res Inst, Madras 600020, Tamil Nadu, India.
RP Christy, RJ (reprint author), USA, Inst Surg Res, Regenerat Med Res Program, 3400 Rawley Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA.
EM robert.christy@amedd.army.mil
OI Natesan, Shanmugasundaram/0000-0003-4213-3111
FU University of Texas Health Science Center, San Antonio, TX [NIH-NCI P30
CA54174, NIH-NIA P30 AG013319, NIH-NIA P01AG19316]
FX The authors would like to thank Ms. Janet Roe for isolation of adipose
tissue and technical support. S.N. was supported by a Postdoctoral
Fellowship Grant from the Pittsburgh Tissue Engineering Initiative.
Confocal images were generated in the core optical imaging facility,
which is supported by the University of Texas Health Science Center, San
Antonio, TX, NIH-NCI P30 CA54174 ( San Antonio Cancer Institute),
NIH-NIA P30 AG013319 (Nathan Shock Center, San Antonio, TX), and NIH-NIA
P01AG19316. The authors also thank Dr. Robert Reddick, Medical Director,
and Lauren Chesnut, Technical Director, Electron Microscopy Facility,
Department of Pathology, the University of Texas Health Science Center,
San Antonio, TX, for use of facility and assistance in the analysis of
electron micrographs.
NR 58
TC 31
Z9 31
U1 1
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD APR
PY 2010
VL 16
IS 4
BP 1369
EP 1384
DI 10.1089/ten.tea.2009.0404
PG 16
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA 579GJ
UT WOS:000276356700024
PM 19916819
ER
PT J
AU Merritt, EK
Hammers, DW
Tierney, M
Suggs, LJ
Walters, TJ
Farrar, RP
AF Merritt, Edward K.
Hammers, David W.
Tierney, Matthew
Suggs, Laura J.
Walters, Thomas J.
Farrar, Roger P.
TI Functional Assessment of Skeletal Muscle Regeneration Utilizing
Homologous Extracellular Matrix as Scaffolding
SO TISSUE ENGINEERING PART A
LA English
DT Article
ID ABDOMINAL-WALL DEFECTS; OPERATION-IRAQI-FREEDOM; ACELLULAR MATRIX;
BONE-MARROW; MOUSE MODEL; STEM-CELL; IN-VIVO; REPAIR; RAT; LACERATION
AB The loss of a portion of skeletal muscle poses a unique challenge for the normal regeneration of muscle tissue. A transection injury with tissue loss will not heal due to the gap between muscle segments. A damage model was developed by removing a portion of the lateral gastrocnemius (GAS) of Sprague-Dawley rats. Maximal isometric, tetanic tension (P-o) was measured after the removal of either a small defect (0.5 x 1.0 cm) or a large defect (1.0 x 1.0 cm) piece of the GAS. In situ P-o immediately after creation of the defect was 88.3 +/- 2.0% of the non-operated contralateral GAS force for small defect and 76.9 +/- 3.2% of control for large defect. No functional recovery occurred in either group over the course of 28 days. To enhance recovery, a homologous, decellularized, muscle extracellular matrix (ECM) was implanted into the 1 x 1 cm defect of the lateral GAS of Lewis rats. After 42 days, growth of blood vessels and myofibers into the ECM was apparent, but no restoration of P-o occurred. These data demonstrate the ability of the ECM to support muscle and blood vessel regeneration, but full recovery of function does not occur after 42 days.
C1 [Merritt, Edward K.; Hammers, David W.; Tierney, Matthew; Farrar, Roger P.] Univ Texas Austin, Dept Kinesiol, Austin, TX 78712 USA.
[Suggs, Laura J.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA.
[Walters, Thomas J.] USA, Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA.
RP Farrar, RP (reprint author), Univ Texas Austin, Dept Kinesiol, 1 Univ Stn D3700, Austin, TX 78712 USA.
EM rfarrar@mail.utexas.edu
FU U.S. Army MRMC [DAMD W81XWH-06-1-0540]
FX This work was funded by the U.S. Army MRMC Grant DAMD W81XWH-06-1-0540.
NR 42
TC 54
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U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD APR
PY 2010
VL 16
IS 4
BP 1395
EP 1405
DI 10.1089/ten.tea.2009.0226
PG 11
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA 579GJ
UT WOS:000276356700026
PM 19929169
ER
PT J
AU Naumann, JC
Bissett, SN
Young, DR
Edwards, J
Anderson, JE
AF Naumann, Julie C.
Bissett, Spencer N.
Young, Donald R.
Edwards, Jarrod
Anderson, John E.
TI Diurnal patterns of photosynthesis, chlorophyll fluorescence, and PRI to
evaluate water stress in the invasive species, Elaeagnus umbellata
Thunb.
SO TREES-STRUCTURE AND FUNCTION
LA English
DT Article
DE Elaeagnus; PRI; Fluorescence; Photosynthesis; Chlorophyll; Drought
stress
ID NET CO2 ASSIMILATION; DESERT SHRUB; ENERGY-DISSIPATION;
ENCELIA-FARINOSA; LEAF PUBESCENCE; C-3 PLANTS; EFFICIENCY; LEAVES;
STATE; PHOTOPROTECTION
AB Photosynthesis, chlorophyll fluorescence, and hyperspectral reflectance were used to evaluate diurnal changes of Elaeagnus umbellata to quantify physiological responses of the invasive species during times of stress. Field measurements showed that E. umbellata is able to maintain higher levels of photosynthesis relative to nearby Quercus alba plants, with less water loss. Plants subjected to progressive drought were able to recover photosynthesis one day following re-watering. Laboratory and field measurements revealed decreasing Delta F/F'(m) values in response to drought stress, with little corresponding decrease in photochemical reflectance index values. This research supports the view that xanthophyll cycle dissipation is not the photoprotective mechanism at work for Elaeagnus species under water stress. Elaeagnus umbellata maintains photosynthetic carbon assimilation even under drought conditions, in part, due to chemical dissipation of excess light, and in part because of morphological features that limit excess radiation while maximizing photosynthetic carbon gain. These characteristics may contribute to the invasive success of E. umbellata.
C1 [Naumann, Julie C.; Edwards, Jarrod; Anderson, John E.] US Army, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA.
[Naumann, Julie C.; Bissett, Spencer N.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
RP Naumann, JC (reprint author), US Army, Erdc, Fluorescence Spect Lab, 7701 Telegraph Rd, Alexandria, VA 22315 USA.
EM jczinner@vcu.edu
FU United States Army Research Office; U.S. Army Corps of
Engineers/Engineer Research and Development Center (ERDC)
FX The authors thank Cody Connolly, Sheri Shiflett, and Ellen Young for
help with field and laboratory measurements. This research was support
by a grant to DRY from the United States Army Research Office. This
research was also supported in part by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Corps of
Engineers/Engineer Research and Development Center (ERDC) administered
by the Oak Ridge Institute for Science and Education through an
interagency agreement between the US Department of Energy and ERDC.
NR 36
TC 11
Z9 12
U1 5
U2 30
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0931-1890
J9 TREES-STRUCT FUNCT
JI Trees-Struct. Funct.
PD APR
PY 2010
VL 24
IS 2
BP 237
EP 245
DI 10.1007/s00468-009-0394-0
PG 9
WC Forestry
SC Forestry
GA 570QZ
UT WOS:000275694400003
ER
PT J
AU Hakami, RM
Ruthel, G
Stahl, AM
Bavari, S
AF Hakami, Ramin Mollaaghababa
Ruthel, Gordon
Stahl, Andrea M.
Bavari, Sina
TI Gaining ground: assays for therapeutics against botulinum neurotoxin
SO TRENDS IN MICROBIOLOGY
LA English
DT Review
ID TOXIN TYPE-A; SMALL-MOLECULE INHIBITORS; SEROTYPE-B; CLOSTRIDIAL
NEUROTOXINS; CONFORMATIONAL-CHANGES; PROTEASE ACTIVITY; LIGHT-CHAIN;
IN-VIVO; SUBSTRATE; IDENTIFICATION
AB Owing in part to recently heightened concern over bio-terrorism, interest in the mechanism of action of botulinum neurotoxin (BoNT) and development of effective therapeutic strategies has dramatically increased. The emergence of BoNT as an effective treatment for a variety of neurological disorders and its growing use in the cosmetic industry have also increased interest in developing effective countermeasures. Although recent attempts to create effective vaccines appear promising, the multitude of clinical and cosmetic uses of BoNT make mass vaccination against the toxin undesirable and impractical, leading to intensified efforts to develop effective therapeutics to combat large-scale intoxications. In this review, we examine the relevant and available in vitro cell-based assays and in vivo assays for drug discovery and development, especially with regard to the potential for medium- to high-throughput automation and its use in identifying physiologically relevant inhibitors.
C1 [Hakami, Ramin Mollaaghababa] Oak Ridge Associated Univ, Fac Res Participat Program, Belcamp, MD USA.
[Hakami, Ramin Mollaaghababa; Ruthel, Gordon; Stahl, Andrea M.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA.
[Hakami, Ramin Mollaaghababa] Akimeka Technol LLC, Honolulu, HI USA.
RP Hakami, RM (reprint author), Oak Ridge Associated Univ, Fac Res Participat Program, Belcamp, MD USA.
EM ramin.hakami@us.army.mil; sina.bavari@us.army.mil
FU Defense Threat Reduction Agency [3.10084_09_RD_B]
FX We thank Dr James J. Schmidt and Dr Erkan Kiris for their insightful
contributions to the manuscript. The views, opinions and/or findings
presented here are those of the authors and should not be construed as
an official Department of the Army position, policy or decision unless
designated by other documentation. This work was supported by a grant
from the Defense Threat Reduction Agency (3.10084_09_RD_B to S.B.).
NR 67
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U1 0
U2 7
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0966-842X
J9 TRENDS MICROBIOL
JI Trends Microbiol.
PD APR
PY 2010
VL 18
IS 4
BP 164
EP 172
DI 10.1016/j.tim.2010.02.001
PG 9
WC Biochemistry & Molecular Biology; Microbiology
SC Biochemistry & Molecular Biology; Microbiology
GA 585DH
UT WOS:000276804000004
PM 20202845
ER
PT J
AU Zhang, HF
Turner, JA
Yang, JS
Kosinski, JA
AF Zhang, Haifeng
Turner, Joseph A.
Yang, Jiashi
Kosinski, John A.
TI Force-frequency effect of thickness mode langasite resonators
SO ULTRASONICS
LA English
DT Article
DE Force-frequency effect; Langasite; Resonators
ID PERTURBATION-THEORY; QUARTZ; LANGATATE; LANGANITE; SHIFTS
AB Langasite resonators are of recent interest for a variety of applications because of their good temperature behavior, good piezoelectric coupling, low acoustic loss and high Q factor. The force-frequency effect describes the shift in resonant frequency a resonator experiences due to the application of a mechanical load. A clear understanding of this effect is essential for many design applications such as pressure sensors. In this article, the frequency shift is analyzed theoretically and numerically for thin, circular langasite plates subjected to a pair of diametrical forces. In addition, the sensitivity of the force-frequency effect is analyzed with respect to the nonlinear material constants. The results are anticipated to be valuable for experimental measurements of nonlinear material constants as well as for device design. (C) 2009 Published by Elsevier B. V.
C1 [Zhang, Haifeng; Turner, Joseph A.; Yang, Jiashi] Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA.
[Kosinski, John A.] US Army RDECOM CERDEC, ATTN AMSRD CER IW DT, Ft Monmouth, NJ 07703 USA.
RP Turner, JA (reprint author), Univ Nebraska, Dept Engn Mech, W317-4 Nebraska Hall, Lincoln, NE 68588 USA.
EM jaturner@unl.edu
RI Turner, Joseph/F-5165-2010
FU Army Research Office [DAAD19-01-1-0443]
FX E. Bigler is gratefully acknowledged for his assistance in providing the
experimental data for inclusion in Fig. 15. We would also like to thank
Bill Horton and Eric Hague of MtronPTI for their helpful suggestions for
this article. [This research was supported by the Army Research Office
under Grant No. DAAD19-01-1-0443.]
NR 26
TC 6
Z9 6
U1 1
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0041-624X
J9 ULTRASONICS
JI Ultrasonics
PD APR
PY 2010
VL 50
IS 4-5
BP 479
EP 490
DI 10.1016/j.ultras.2009.10.008
PG 12
WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
GA 554PI
UT WOS:000274446500007
PM 19942246
ER
PT J
AU Furusato, B
Tsunoda, T
Shaheduzzaman, S
Nau, ME
Vahey, M
Petrovics, G
McLeod, DG
Naito, S
Shirasawa, S
Srivastava, S
Sesterhenn, IA
AF Furusato, Bungo
Tsunoda, Toshiyuki
Shaheduzzaman, Syed
Nau, Martin E.
Vahey, Maryanne
Petrovics, Gyorgy
McLeod, David G.
Naito, Seiji
Shirasawa, Senji
Srivastava, Shiv
Sesterhenn, Isabell A.
TI Osteoblast-specific Factor 2 Expression in Prostate Cancer-associated
Stroma: Identification Through Microarray Technology
SO UROLOGY
LA English
DT Article
ID CELL ADHESION MOLECULE; REACTIVE STROMA; PROGNOSTIC MARKER;
TUMOR-STROMA; PERIOSTIN; PROGRESSION; CARCINOMA; MYOFIBROBLASTS;
TRANSCRIPTOME; FIBROBLASTS
AB OBJECTIVES To better understand the gene expression patterns in tumor-associated stroma, laser-capture-microdissections from clinical specimens were analyzed by genome-wide-expression microarray technology. The epithelial-stromal interaction plays a critical role in prostate development, reactive changes, and tumorigenesis. Diverse microarray technologies have been used to characterize the molecular changes in prostate cancer. Even though these gene expression studies are compromised by the heterogeneity of the tumor, as well as by the difficulty associated with collecting appropriate counterparts to represent normal prostate cells, the gene array data from tumors have shown promising results. Currently, little is known about the tumor-associated stromal gene expression profile in prostate cancer.
METHODS Matching benign and malignant epithelial cell-related stroma cells were subjected to microarray platforms.
RESULTS The prostatatic stroma expressed several osteogenic molecules. In particular, one of the genes, OSF2, was upregulated in tumor-associated stroma compared with benign epithelial cell associated stroma, which was further validated by immunohistochemical examination.
CONCLUSIONS These data show that the combination of laser capture dissection with computational enhancement of epithelial and stromal microarray data is a useful tool to assess gene expression changes in prostate cancer stroma. UROLOGY 75: 768-772, 2010. (C) 2010 Elsevier Inc.
C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA.
Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA.
[Furusato, Bungo] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA.
Fukuoka Univ, Fac Med, Dept Cell Biol, Jonan Ku, Fukuoka 81401, Japan.
Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA.
Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA.
Kyushu Univ, Grad Sch Med Sci, Dept Urol, Fukuoka 812, Japan.
RP Furusato, B (reprint author), Armed Forces Inst Pathol, Dept Genitourinary Pathol, 6825 16 Th St NW, Washington, DC 20306 USA.
EM bfurusato@cpdr.org; sesterhe@afip.osd.mil
OI Furusato, Bungo/0000-0003-4614-9882
NR 30
TC 3
Z9 4
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0090-4295
J9 UROLOGY
JI Urology
PD APR
PY 2010
VL 75
IS 4
BP 768
EP 772
DI 10.1016/j.urology.2009.10.026
PG 5
WC Urology & Nephrology
SC Urology & Nephrology
GA 577XW
UT WOS:000276258300003
PM 20035976
ER
PT J
AU Ozkaya, E
Dincer, E
Carhan, A
Uyar, Y
Ertek, M
Whitehouse, CA
Ozkul, A
AF Ozkaya, Etem
Dincer, Ender
Carhan, Ahmet
Uyar, Yavuz
Ertek, Mustafa
Whitehouse, Chris A.
Ozkul, Aykut
TI Molecular epidemiology of Crimean-Congo hemorrhagic fever virus in
Turkey: Occurrence of local topotype
SO VIRUS RESEARCH
LA English
DT Article
DE CCHFV; S-segment; M-segment; Phylogenetic analysis; Turkey; Arboviruses;
Bunyaviruses
ID NEIGHBOR-JOINING METHOD; GENETIC-ANALYSIS; RNA SEGMENT; RUSSIA;
PHYLOGENIES; STRAINS; KOSOVO
AB The goal of this study was to investigate the molecular epidemiology of Crimean-Congo hemorrhagic fever virus (CCHFV) in Turkey. The study was performed on a total of 48 confirmed human CCHF cases from 2006 to 2008. The majority of the CCHF viral strains in Turkey were found to belong to the European lineage. Local CCHF viral strains are grouped into two main clusters, which can be further divided into two sub-groups. We also identified an AP92-like virus causing clinical disease in Corum (a mid-Anatolian province). Phylogenetic analysis revealed that the most recent CCHFV infections were caused by intrinsic (or native) CCHF viral strains, which we identified as the local topotype. Comparison of deduced amino acid sequences of S-segment RNAs indicated that the local topotype was derived from viruses of previous years, most likely by a low rate recombination. No genetic differences, based on S- and M-segment RNA sequences, were found between human and tick viral isolates. This data suggest that replication of CCHFV in the tick vector, whether Rhiphicephalus spp. or Hyalomma spp., has no effect on the viral genomic structure. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Ozkul, Aykut] Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey.
[Ozkaya, Etem; Carhan, Ahmet; Uyar, Yavuz; Ertek, Mustafa] Minist Hlth, RSNPHA, Virol Reference & Res Lab, TR-06100 Ankara, Turkey.
[Dincer, Ender] Ankara Univ, Inst Biotechnol, TR-06500 Ankara, Turkey.
[Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Ozkul, A (reprint author), Ankara Univ, Fac Vet Med, Dept Virol, TR-06110 Ankara, Turkey.
EM ozkul@veterinary.ankara.edu.tr
RI Dincer, Ender/B-1350-2016;
OI Carhan, Ahmet/0000-0003-1584-0072
FU RSNPHA Virology Reference and Research Laboratory
FX Authors would like to thank to Directory of Refik Saydam National Public
Health Agency (RSNPHA) for providing local CCHF virus isolated and to
teh technical staff of RSNPHA Virology Reference and Research Laboratory
for their kind support.
NR 31
TC 31
Z9 31
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1702
J9 VIRUS RES
JI Virus Res.
PD APR
PY 2010
VL 149
IS 1
BP 64
EP 70
DI 10.1016/j.virusres.2009.12.014
PG 7
WC Virology
SC Virology
GA 579BQ
UT WOS:000276341900009
PM 20079776
ER
PT J
AU Shearer, JF
AF Shearer, Judy F.
TI A Historical Perspective of Pathogen Biological Control of Aquatic
Plants
SO WEED TECHNOLOGY
LA English
DT Article
DE Aquatic plant management; integrated pest management
ID HYACINTH EICHHORNIA-CRASSIPES; WATER-HYACINTH; HYDRILLA-VERTICILLATA;
INTEGRATED CONTROL; MYCOLEPTODISCUS-TERRESTRIS; EURASIAN WATERMILFOIL;
MYRIOPHYLLUM-SPICATUM; CERCOSPORA-RODMANII; FUSARIUM-CULMORUM; FUNGAL
PATHOGEN
AB Pathogens were not seriously considered as biological control agents for aquatic plants in the United States until the Chesapeake Bay Eurasian watermilfoil decline occurred in the 1960s. The decline and suggestion that it was induced by pathogens spawned interest in the use of pathogens as biological control agents for nuisance aquatic species. In the years that followed, emphasis was placed on finding pathogen agents for some of the most problematic aquatic weeds, including waterhyacinth, Eurasian watermilfoil, and hydrilla. The scientist that has contributed the most to our knowledge of pathogen biological control in aquatic plants has been Dr. Raghavan Charudattan (University of Florida, Gainesville, FL). For the past 40 yr, he has authored or coauthored more than 50 manuscripts devoted to the subject in peer-reviewed journals, books, and proceedings.
C1 USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA.
RP Shearer, JF (reprint author), USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA.
EM Judy.F.Shearer@usace.army.mil
FU USACE, Engineer Research and Development Center, Environmental
Laboratory
FX Support for this manuscript came from the USACE, Engineer Research and
Development Center, Environmental Laboratory, Aquatic Plant Control
Research Program (Vicksburg, MS). Permission was granted by the Chief of
Engineers to publish this information.
NR 58
TC 2
Z9 2
U1 1
U2 16
PU WEED SCI SOC AMER
PI LAWRENCE
PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA
SN 0890-037X
J9 WEED TECHNOL
JI Weed Technol.
PD APR-JUN
PY 2010
VL 24
IS 2
BP 202
EP 207
DI 10.1614/WT-D-09-00001.1
PG 6
WC Agronomy; Plant Sciences
SC Agriculture; Plant Sciences
GA 603JE
UT WOS:000278204000022
ER
PT J
AU Wang, HC
Brown, J
Alayon, H
Stuck, BE
AF Wang, Heuy-Ching
Brown, Jeremiah
Alayon, Helena
Stuck, Bruce E.
TI Transplantation of quantum dot-labelled bone marrow-derived stem cells
into the vitreous of mice with laser-induced retinal injury: Survival,
integration and differentiation
SO VISION RESEARCH
LA English
DT Article; Proceedings Paper
CT 12th Annual Vision Research Conference on Mechanisms of Macular
Degeneration
CY MAY 01-02, 2009
CL Lauderdale, FL
SP Convent Ctr
DE Laser-induced retinal injury; Lineage negative bone marrow cells;
Photoreceptor apoptosis; Choroid neovascularization; Retinal pigment
epithelium
ID ENDOTHELIAL PROGENITOR CELLS; CHOROIDAL NEOVASCULARIZATION;
PHOTORECEPTOR SURVIVAL; DIABETIC-RETINOPATHY; PIGMENT EPITHELIUM;
VASCULAR REPAIR; STROMAL CELLS; DEGENERATION; MODEL; RESCUE
AB Accidental laser exposure to the eyes may result in serious visual impairment due to retina degeneration. Currently limited treatment is available for laser eye injury. In the current study, we investigated the therapeutic potential of bone marrow-derived stem cells (BMSCs) for laser-induced retinal trauma. Lineage negative bone marrow cells (Lin(-) BMCs) were labelled with quantum dots (Qdots) to track the cells in vivo. Lin(-) BMCs survived well after intravitreal injection. In vivo bromodeoxyuridine (BrdU) labelling showed these cells continued to proliferate and integrate into injured retinas. Furthermore, they expressed markers that distinguished retinal pigment epithelium (RPE), endothelium, pericytes and photoreceptors. Our results suggest that BMSCs participate in the repair of retinal lesions by differentiating into retinal cells. Intravitreal transplantation of BMSCs is a potential treatment for laser-induced retinal trauma. Published by Elsevier Ltd.
C1 [Wang, Heuy-Ching; Alayon, Helena; Stuck, Bruce E.] USA Med Res Detachment, Walter Reed Army Inst Res, Brooks City Base, TX 78235 USA.
[Brown, Jeremiah] Northrop Grumman, San Antonio, TX USA.
RP Wang, HC (reprint author), USA Med Res Detachment, Walter Reed Army Inst Res, 7965 Dave Erwin Dr, Brooks City Base, TX 78235 USA.
EM Heuy-ching.hetty.wang@us.army.mil
NR 40
TC 25
Z9 28
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0042-6989
J9 VISION RES
JI Vision Res.
PD MAR 31
PY 2010
VL 50
IS 7
SI SI
BP 665
EP 673
DI 10.1016/j.visres.2009.09.003
PG 9
WC Neurosciences; Ophthalmology
SC Neurosciences & Neurology; Ophthalmology
GA 574OP
UT WOS:000276000600005
PM 19782698
ER
PT J
AU Samet, ED
AF Samet, Elizabeth D.
TI Man of Letters Captain Whitten was my student.
SO NEW REPUBLIC
LA English
DT Editorial Material
C1 US Mil Acad, West Point, NY 10996 USA.
RP Samet, ED (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NEW REPUBLIC INC
PI WASHINGTON
PA 1331 H STREET, NW STE 700, WASHINGTON, DC 20005 USA
SN 0028-6583
J9 NEW REPUBLIC
JI New Repub.
PD MAR 25
PY 2010
VL 241
IS 4
BP 5
EP 6
PG 2
WC Political Science
SC Government & Law
GA 568SU
UT WOS:000275543800003
ER
PT J
AU Clements, DE
Coller, BAG
Lieberman, MM
Ogata, S
Wang, G
Harada, KE
Putnak, JR
Ivy, JM
McDonell, M
Bignami, GS
Peters, ID
Leung, J
Weeks-Levy, C
Nakano, ET
Humphreys, T
AF Clements, David E.
Coller, Beth-Ann G.
Lieberman, Michael M.
Ogata, Steven
Wang, Gordon
Harada, Kent E.
Putnak, J. Robert
Ivy, John M.
McDonell, Michael
Bignami, Gary S.
Peters, Iain D.
Leung, Julia
Weeks-Levy, Carolyn
Nakano, Eileen T.
Humphreys, Tom
TI Development of a recombinant tetravalent dengue virus vaccine:
Innmunogenicity and efficacy studies in mice and monkeys
SO VACCINE
LA English
DT Article
DE Dengue; Envelope; Subunit; Vaccine
ID ENVELOPE GLYCOPROTEIN; HEMORRHAGIC-FEVER; NEUTRALIZING ANTIBODIES;
MONOCLONAL-ANTIBODIES; STRUCTURAL PROTEINS; DISEASE SEVERITY; STRAIN
16681; CDNA-CLONES; CELLS; DETERMINANTS
AB Truncated recombinant dengue virus envelope protein subunits (80E) are efficiently expressed using the Drosophila Schneider-2 (S2) cell expression system. Binding of conformationally sensitive antibodies as well as X-ray crystal structural studies indicate that the recombinant 80E subunits are properly folded native-like proteins. Combining the 80E subunits from each of the four dengue serotypes with ISCOMATRIX (R) adjuvant, an adjuvant selected from a set of adjuvants tested for maximal and long lasting immune responses, results in high titer virus neutralizing antibody responses. Immunization of mice with a mixture of all four 80E subunits and ISCOMATRIX (R) adjuvant resulted in potent virus neutralizing antibody responses to each of the four serotypes. The responses to the components of the tetravalent mixture were equivalent to the responses to each of the subunits administered individually. In an effort to evaluate the potential protective efficacy of the Drosophila expressed 80E, the dengue serotype 2 (DEN280E) subunit was tested in both the mouse and monkey challenge models. In both models protection against viral challenge was achieved with low doses of antigen in the vaccine formulation. In non-human primates, low doses of the tetravalent formulation induced good virus neutralizing antibody titers to all four serotypes and protection against challenge with the two dengue virus serotypes tested. In contrast to previous reports, where subunit vaccine candidates have generally failed to induce potent, protective responses, native-like soluble 80E proteins expressed in the Drosophila S2 cells and administered with appropriate adjuvants are highly immunogenic and capable of eliciting protective responses in both mice and monkeys. These results support the development of a dengue virus tetravalent vaccine based on the four 80E subunits produced in the Drosophila S2 cell expression system. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Clements, David E.; Coller, Beth-Ann G.; Lieberman, Michael M.; Ogata, Steven; Wang, Gordon; Harada, Kent E.; Ivy, John M.; McDonell, Michael; Bignami, Gary S.; Peters, Iain D.; Leung, Julia; Weeks-Levy, Carolyn; Nakano, Eileen T.; Humphreys, Tom] Hawaii Biotech Inc, Aiea, HI 96701 USA.
[Putnak, J. Robert] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Coller, BAG (reprint author), Hawaii Biotech Inc, 99-193 Aiea Hts Dr, Aiea, HI 96701 USA.
EM coller@hibiotech.com
FU Public Health Service [1 R43A135401, 2 R44A135401]; USDA [1890-119];
Department of Defense [DAMD17-93-C-3128]
FX The authors thank Dennis Trent formerly at the Food and Drug
Administration for providing dengue viral strains and Alan Shatzman at
GSK for the Drosophila expression vectors. They also thank Y.S. Hahn for
the gift of the plasmid pC8. The authors also thank James Senda, Eric
Rohlinger, Beverly Orillo, Timothy Martyak, Michael Thorne, Teri Wong,
Milicent Yong, Abu Aslamkhan, Tim Chamberlain, and David Chang for
excellent technical assistance. This work was supported by Public Health
Service Grants 1 R43A135401 and 2 R44A135401, USDA Contract 1890-119,
and a grant from the Department of Defense DAMD17-93-C-3128.
NR 65
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U1 3
U2 19
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD MAR 24
PY 2010
VL 28
IS 15
BP 2705
EP 2715
DI 10.1016/j.vaccine.2010.01.022
PG 11
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 576UK
UT WOS:000276174600004
PM 20097152
ER
PT J
AU Byrd, CM
Xiong, ZQ
Tsao, CY
Bentley, WE
AF Byrd, Christopher M.
Xiong, Zhiqiang
Tsao, Chen-Yu
Bentley, William E.
TI Understanding mechanistic basis for QS signaling via ChIP-Chip analysis
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
USA, Res Lab, Sensors & Electon Devices Directorate, Adelphi, MD USA.
Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA.
Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 7-BIOT
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189300685
ER
PT J
AU Chappell, MA
Mao, JD
Ford, LS
Price, CL
AF Chappell, Mark A.
Mao, Jing-Dong
Ford, Lesley S.
Price, Cynthia L.
TI Biochars and soil humic surfactancy
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 USA, Engn Res & Dev Ctr, Vicksburg, MS USA.
Old Domin Univ, Dept Chem, Norfolk, VA USA.
SpecPro Inc, Huntsville, AL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 439-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189302383
ER
PT J
AU Getsinger, KD
AF Getsinger, Kurt D.
TI Status and future of herbicide use for controlling invasive aquatic
plants
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 USA, Corps Engineers, Dept Engineer Res, Vicksburg, MS 39180 USA.
USA, Corps Engineers, Dev Ctr, Vicksburg, MS 39180 USA.
NR 0
TC 0
Z9 0
U1 1
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 44-AGRO
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189300228
ER
PT J
AU Gu, ZF
Bauman, RA
Long, JB
AF Gu, Zengfa
Bauman, Richard A.
Long, Joseph B.
TI Paraoxon causes brain injury and increases the total power of EEG
(Electroencephalography) in rats
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Gu, Zengfa; Bauman, Richard A.; Long, Joseph B.] Walter Reed Army Inst Res, Dept Closed Head Injury Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 299-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189302306
ER
PT J
AU Hackley, VA
MacCuspie, RI
Kennedy, AJ
AF Hackley, Vincent A.
MacCuspie, Robert I.
Kennedy, Alan J.
TI Barriers to the environmental, health and safety assessment of silver
nanoparticles
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 NIST, Mat Sci & Engn Lab, Gaithersburg, MD 20899 USA.
USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 10-IEC
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189302721
ER
PT J
AU Lambeth, RH
Pederson, SJ
Rawlett, AM
AF Lambeth, Robert H.
Pederson, Samuel J.
Rawlett, Adam M.
TI Analysis and removal of residual catalyst from ROMP based polymers
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Lambeth, Robert H.; Pederson, Samuel J.; Rawlett, Adam M.] USA, Res Lab, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 320-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189304760
ER
PT J
AU Orlicki, JA
Leadore, JL
Strawhecker, KE
AF Orlicki, Joshua A.
Leadore, Julia L.
Strawhecker, Kenneth E.
TI Physical property gradients driven by light attenuation during
photopolymerization
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Orlicki, Joshua A.; Leadore, Julia L.; Strawhecker, Kenneth E.] USA, Multifunct Mat Branch, Res Lab, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 475-PMSE
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189304634
ER
PT J
AU Riegner, DE
Swayze, MD
Lachance, ZT
AF Riegner, Dawn E.
Swayze, Michael D.
Lachance, Zachary T.
TI Characterization of automated solid phase micro-extraction (SPME) with
GC-Toroidal ion trap mass spectrometry for detection of CWA simulants
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Riegner, Dawn E.; Swayze, Michael D.; Lachance, Zachary T.] United States Mil Acad, Dept Chem & Life Sci, West Point, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 372-CHED
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189301493
ER
PT J
AU Rinderspacher, BC
Andzelm, J
Rawlett, A
Dougherty, J
Lambeth, R
AF Rinderspacher, Berend C.
Andzelm, Jan
Rawlett, Adam
Dougherty, Joseph
Lambeth, Robert
TI Searching chemical space by inverse design
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Rinderspacher, Berend C.; Andzelm, Jan; Rawlett, Adam; Dougherty, Joseph; Lambeth, Robert] USA, Res Lab, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 58-CINF
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189301783
ER
PT J
AU Rinderspacher, BC
Andzelm, J
Rawlett, AM
Dougherty, J
AF Rinderspacher, Berend Christopher
Andzelm, Jan
Rawlett, Adam M.
Dougherty, Joseph
TI Influence of p-bridges in push-pull-chromophores on the
transparency-hyperpolarizability tradeoff
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Rinderspacher, Berend Christopher; Andzelm, Jan; Rawlett, Adam M.; Dougherty, Joseph] RDRL WMM A Army Res Lab, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 21
PY 2010
VL 239
MA 136-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V21DW
UT WOS:000208189302088
ER
PT J
AU Guo, JS
Hsu, A
Chu, D
Chen, RR
AF Guo, Junsong
Hsu, Andrew
Chu, Deryn
Chen, Rongrong
TI Improving Oxygen Reduction Reaction Activities on Carbon-Supported Ag
Nanoparticles in Alkaline Solutions
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID MEMBRANE FUEL-CELLS; CATALYSTS; PLATINUM; SILVER; HYDRAZINE; OXIDATION;
ELECTROCATALYSTS; ELECTROREDUCTION; ELECTROLYTE; MECHANISM
AB Carbon-supported Ag (Ag/C) catalysts with four different metal loadings were prepared by a citrate-protecting method. Oxygen reduction reaction (ORR) activities oil these carbon-supported Ag-nanocatalysts (Ag/C) in alkaline solutions were Studied. Four major findings are reported in this paper: (1) Test results indicate that the Ag/C catalysts promote predominately a four-electron pathway for ORR oil electrodes over the swept potentials from 0.2 to -0.8 V vs Hg/HgO in O(2)-saturated 0.1 M NaOH Solutions. (2) A novel marker for predicting ORR activities on the Ag/C catalysts based oil the cyclic voltammetry characteristic Curves has been identified: the ORR activities have a strong correlation with the intensity of the anodic peak at the potential of 0.230 V vs Hg/HgO in Ar-saturated 0.1 M NaOH Solutions. (3) As the metal loading on carbon particles increases from 10 to 60 wt %, the peak intensities increase linearly, and the ORR onset potentials shift positively with maximum shift of 62 mV for 60% Ag oil carbon Support. (4) A hitherto unnoticed poisoning effect has been discovered: silicate has a significant poisoning effect oil the ORR activities of the Ag/C catalysts.
C1 [Guo, Junsong; Hsu, Andrew; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46204 USA.
[Chu, Deryn] Army Res Lab, Adelphi, MD 20783 USA.
RP Guo, JS (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46204 USA.
FU U.S. Army Research Lab [W911NF-07-2-0036]
FX This work was supported by the U.S. Army Research Lab (Grant No.
W911NF-07-2-0036).
NR 28
TC 143
Z9 146
U1 12
U2 127
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD MAR 18
PY 2010
VL 114
IS 10
BP 4324
EP 4330
DI 10.1021/jp910790u
PG 7
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 565XD
UT WOS:000275328700011
ER
PT J
AU Dirlam, PT
Strange, GA
Orlicki, JA
Wetzel, ED
Costanzo, PJ
AF Dirlam, Philip T.
Strange, Gregory A.
Orlicki, Joshua A.
Wetzel, Eric D.
Costanzo, Philip J.
TI Controlling Surface Energy and Wetability with Diels-Alder Chemistry
SO LANGMUIR
LA English
DT Article
ID 3-DIMENSIONAL MICROVASCULAR NETWORKS; HOLLOW GLASS-FIBERS; MICROFLUIDICS
AB Reversible Diels-Alder chemistry was utilized to manipulate the surface energy of glass substrates. Hydrophobic dieneophiles were prepared and attached to glass slides and capillaries to yield a nonwetting surface. Thermal treatment of the surfaces cleaved the Diels-Alder linkage, and resulted in the fabrication of a hydrophilic surface. Preliminary analysis utilized contact angle (CA) Measurements to monitor the change ill Surface energy, and observed a hydrophilic state (CA - 70 +/- 3 degrees) before attachment of the dieneophile to a hydrophobic state (CA - 101 +/- 9 degrees) followed by regeneration of the hydrophilic state (CA - 70 +/- 6 degrees) upon cleavage of the Diels-Alder linkage. The treatments were then applied to glass capillaries, with effective treatment confirmed by fluid column measurements. Patterned treatments were also demonstrated to provide effective flow gating. Finally, attempts to create self-pressurizing capillaries were unsuccessful due to pronounced contact angle hysteresis for the hydrophobic surface treatment.
C1 [Dirlam, Philip T.; Strange, Gregory A.; Costanzo, Philip J.] Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA.
[Orlicki, Joshua A.; Wetzel, Eric D.] USA, Res Lab, Div Mat, Aberdeen, MD 21005 USA.
RP Costanzo, PJ (reprint author), Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA.
EM pcostanz@calpoly.edu
RI Costanzo, Philip/E-8879-2011
OI Costanzo, Philip/0000-0001-6220-463X
FU U.S. Army Research Laboratory through the Army Materials Center of
Excellence [W911NF-O6-2-0013]; California Polytechnic State University
FX Funding and support were provided by the U.S. Army Research Laboratory
through the Army Materials Center of Excellence (W911NF-O6-2-0013)
program at Drexel University. Additional funding was provided by
California Polytechnic State University via start-up funds. Prof.
Giuseppe Palinese of Drexel University is acknowledged for stimulating
our interest in reversible surface treatments for control of vascular
flows. Finally, we would like to acknowledge and thank the Materials
Research Facilities Network (MRFN) program at the University of
California, Santa Barbara, (NSF-DMR-0520415) for providing
instrumentation support used to obtain XPS analysis of samples.
NR 25
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Z9 11
U1 2
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD MAR 16
PY 2010
VL 26
IS 6
BP 3942
EP 3948
DI 10.1021/la9032805
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA 564PE
UT WOS:000275226700030
PM 20020732
ER
PT J
AU Opperman, TJ
Williams, JD
Houseweart, C
Panchal, RG
Bavari, S
Peet, NP
Moir, DT
Bowlin, TL
AF Opperman, Timothy J.
Williams, John D.
Houseweart, Chad
Panchal, Rekha G.
Bavari, Sina
Peet, Norton P.
Moir, Donald T.
Bowlin, Terry L.
TI Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals
differential substrate specificities for MepA and MepR
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Resistance; Bis-indole antibiotics; Efflux; MepR; MepA; Staphylococcus
aureus
ID MATE FAMILY; REDUCED SUSCEPTIBILITY; MULTIDRUG-RESISTANCE; BACTERIAL
GENOMES; PUMP MEPA; BINDING; OVEREXPRESSION; EXPRESSION; PROTEIN; GROOVE
AB The bis-indoles are a novel class of compounds with potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative pathogens. The mechanism of action of these compounds has not been clearly defined. To study the mechanism of action of bis-indoles, selections for mutants of Staphylococcus aureus NCTC 8325 with reduced susceptibility to several chemically related bis-indoles were carried out using serial passages in subinhibitory compound concentrations. Resistant mutants were only obtained for one of the four bis-indoles tested (MBX-1090), and these appeared at concentrations up to 16X MIC within 10-12 passages. MBX-1090 resistance mutations produced a truncated open reading frame of mepR (SAOUHSC_00314), a gene encoding a MarR-like repressor. MepR regulates expression of mepA (SAOUHSC_00315), which encodes a member of the Multidrug and Toxic Compound Extrusion (MATE) family of efflux pumps. MBX-1090 resistance was reverted when mepR (wild type) was provided in trans. Microarray experiments and RT-PCR experiments confirmed that over-expression of mepA is required for resistance. Interestingly, MBX-1090 resistant mutants and strains overexpressing mepA from an expression vector did not exhibit cross-resistance to closely related bis-indole compounds. MBX-1090 did not induce expression of mepA, suggesting that this compound does not directly interact with MepR. Conversely, the bis-indoles that were not substrates of MepA strongly induced mepA expression. The results of this study suggest that MepA and MepR exhibit remarkably distinct substrate specificity for closely related bis-indoles. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Opperman, Timothy J.; Williams, John D.; Houseweart, Chad; Peet, Norton P.; Moir, Donald T.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01605 USA.
[Panchal, Rekha G.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Opperman, TJ (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01605 USA.
EM topperman@microbiotix.com
OI Williams, John/0000-0001-6609-3842
FU Defense Threat Reduction Agency [HDTRA1-06-C-0042]
FX This project has been funded by the following contract from the Defense
Threat Reduction Agency: HDTRA1-06-C-0042. The authors would like to
thank Bing Li for the calculations describing the predicted physical
properties of the bis-indoles.
NR 26
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U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD MAR 15
PY 2010
VL 18
IS 6
BP 2123
EP 2130
DI 10.1016/j.bmc.2010.02.005
PG 8
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
Organic
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 568HR
UT WOS:000275513700007
PM 20188576
ER
PT J
AU Mantey, K
Kwit, M
Nayfeh, MH
Kumar, A
Stephenson, LD
Nelson, AJ
AF Mantey, Kevin
Kwit, Matthew
Nayfeh, M. H.
Kumar, Ashok
Stephenson, Larry D.
Nelson, Andrew J.
TI Measurement of the photostability of silicon nanoparticles under UVA and
near infrared irradiation
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
DE disperse systems; dyes; elemental semiconductors; gels; laser materials
processing; nanoparticles; photoluminescence; quenching (thermal);
silicon; ultraviolet radiation effects
ID ULTRASMALL SI NANOPARTICLES; POROUS SILICON; PHOTOLUMINESCENCE;
ULTRABRIGHT; SURFACES; FILMS
AB We examine the photostability of silicon nanoparticles when they are dispersed in liquid or immobilized in gels or on surfaces. We show that the photoluminescence in static solution develops, under UV irradiation, a long-term stability at the 50% level. Under the same conditions, common dye molecules such as coumarin and stilbene quench with time at rates 8 and 50 fold faster, and exhibit no long-term stability. For the case of immobilized particles in agarose gel as well as on a quartz substrate we used two-photon near infrared femtosecond excitation at 780 nm to induce the blue luminescence. "Parking" the excitation beam, focused on such stationery particles shows that they, unlike similarly immobilized dye molecules, are highly photostable at more than 80%-90% level and do not bleach. The photostability is discussed in terms of excited state interactions and structuring of the silicon outer shell.
C1 [Mantey, Kevin; Kwit, Matthew; Nayfeh, M. H.] Univ Illinois, Dept Phys, Urbana, IL 61801 USA.
[Kumar, Ashok; Stephenson, Larry D.; Nelson, Andrew J.] ERDC CERL, Champaign, IL 61826 USA.
RP Mantey, K (reprint author), Univ Illinois, Dept Phys, 1110 W Green St Urbana, Urbana, IL 61801 USA.
EM m-nayfeh@illinois.edu
NR 30
TC 3
Z9 3
U1 2
U2 15
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD MAR 15
PY 2010
VL 107
IS 6
AR 064316
DI 10.1063/1.3326161
PG 5
WC Physics, Applied
SC Physics
GA 577GP
UT WOS:000276210800096
ER
PT J
AU Eppinger, M
Worsham, PL
Nikolich, MP
Riley, DR
Sebastian, Y
Mou, S
Achtman, M
Lindler, LE
Ravel, J
AF Eppinger, Mark
Worsham, Patricia L.
Nikolich, Mikeljon P.
Riley, David R.
Sebastian, Yinong
Mou, Sherry
Achtman, Mark
Lindler, Luther E.
Ravel, Jacques
TI Genome Sequence of the Deep-Rooted Yersinia pestis Strain Angola Reveals
New Insights into the Evolution and Pangenome of the Plague Bacterium
SO JOURNAL OF BACTERIOLOGY
LA English
DT Article
ID PLASMINOGEN-ACTIVATOR; PHYLOGENETIC ANALYSIS; PNEUMONIC PLAGUE;
PESTOIDES-F; VIRULENCE; BIOVAR; PFRA; PSEUDOTUBERCULOSIS; RESISTANCE;
DIVERSITY
AB To gain insights into the origin and genome evolution of the plague bacterium Yersinia pestis, we have sequenced the deep-rooted strain Angola, a virulent Pestoides isolate. Its ancient nature makes this atypical isolate of particular importance in understanding the evolution of plague pathogenicity. Its chromosome features a unique genetic make-up intermediate between modern Y. pestis isolates and its evolutionary ancestor, Y. pseudotuberculosis. Our genotypic and phenotypic analyses led us to conclude that Angola belongs to one of the most ancient Y. pestis lineages thus far sequenced. The mobilome carries the first reported chimeric plasmid combining the two species-specific virulence plasmids. Genomic findings were validated in virulence assays demonstrating that its pathogenic potential is distinct from modern Y. pestis isolates. Human infection with this particular isolate would not be diagnosed by the standard clinical tests, as Angola lacks the plasmid-borne capsule, and a possible emergence of this genotype raises major public health concerns. To assess the genomic plasticity in Y. pestis, we investigated the global gene reservoir and estimated the pangenome at 4,844 unique protein-coding genes. As shown by the genomic analysis of this evolutionary key isolate, we found that the genomic plasticity within Y. pestis clearly was not as limited as previously thought, which is strengthened by the detection of the largest number of isolate-specific single-nucleotide polymorphisms (SNPs) currently reported in the species. This study identified numerous novel genetic signatures, some of which seem to be intimately associated with plague virulence. These markers are valuable in the development of a robust typing system critical for forensic, diagnostic, and epidemiological studies.
C1 [Eppinger, Mark; Riley, David R.; Ravel, Jacques] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA.
[Eppinger, Mark; Riley, David R.; Ravel, Jacques] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA.
[Worsham, Patricia L.; Mou, Sherry] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
[Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
[Sebastian, Yinong] J Craig Venter Inst, Rockville, MD 20850 USA.
[Achtman, Mark] Univ Coll Cork, ERI, Cork, Ireland.
[Lindler, Luther E.] Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA.
RP Ravel, J (reprint author), Univ Maryland, Sch Med, Inst Genome Sci, 801 W Baltimore St, Baltimore, MD 21201 USA.
EM jravel@som.umaryland.edu
OI Ravel, Jacques/0000-0002-0851-2233
FU National Institute of Allergy and Infectious Diseases, National
Institutes of Health, Department of Health and Human Services [NIAID N01
AI-30071]; Defense Threat Reduction Agency [1.1A0021_07_RD_B]
FX This work was supported with federal funds from the National Institute
of Allergy and Infectious Diseases, National Institutes of Health,
Department of Health and Human Services, under NIAID contract N01
AI-30071, and Defense Threat Reduction Agency JSTO-CBD project
1.1A0021_07_RD_B (P. W. L.).; Opinions, interpretations, conclusions,
and recommendations are those of the authors and are not necessarily
endorsed by the U. S. Army.; We thank Richard Borschel for performing
the guinea pig assay. Research was conducted in compliance with the
Animal Welfare Act and other federal statutes and regulations involving
animals and adheres to the principles stated in the Guide for the Care
and Use of Laboratory Animals, National Research Council, 1996. The
facility where this animal research was conducted is fully accredited by
the Association for Assessment and Accreditation of Laboratory Animal
Care International.
NR 74
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Z9 644
U1 3
U2 20
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0021-9193
J9 J BACTERIOL
JI J. Bacteriol.
PD MAR 15
PY 2010
VL 192
IS 6
BP 1685
EP 1699
DI 10.1128/JB.01518-09
PG 15
WC Microbiology
SC Microbiology
GA 560GW
UT WOS:000274891300023
PM 20061468
ER
PT J
AU Choi, MS
Saxena, A
Chilukuri, N
AF Choi, Moonsuk S.
Saxena, Ashima
Chilukuri, Nageswararao
TI A strategy for the production of soluble human senescence marker
protein-30 in Escherichia coli
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Senescence marker protein-30 (SMP30); Diisopropyl fluorophosphatase
(DFPase); Bacterial expression; Molecular chaperones; Solubility;
Two-step growth
ID RECOMBINANT PROTEINS; TRIGGER FACTOR; DIISOPROPYL PHOSPHOROFLUORIDATE;
INCLUSION-BODIES; LIVER; PURIFICATION; AGGREGATION; CHAPERONES;
EXPRESSION; PROMOTES
AB Senescence marker protein-30 (SMP30) has been reported to hydrolyze diisopropyl fluorophosphate (DFP), a surrogate compound of chemical warfare nerve agents. Thus, SMP30 has the potential to be useful as a prophylactic against chemical warfare nerve agent toxicity. Our efforts to generate human SMP30 in bacteria using a variety of expression vectors invariably resulted in insoluble and inactive preparations. In this study, properly folded and active recombinant human SMP30 (rHuSMP30) was produced in Escherichia coli by coexpressing it with molecular chaperones in a combined strategy. The coexpression of rHuSMP30 with GroES/GroEL/Tf at 15 degrees C, combined with the addition of a membrane fluidizer, increased osmolytes, and a two-step expression resulted in the highest enhancement of solubility and DFPase activity. Our results pave the way for exploring the use of rHuSMP30 against organophosphate and nerve agent toxicity. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Choi, Moonsuk S.; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
[Chilukuri, Nageswararao] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA.
RP Choi, MS (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM moonsuk.choi@amedd.army.mil
FU Defense Threat Reduction Agency [D.0024_07_WR_C]; Department of Defense
(DOD)
FX This work is supported by a grant from Defense Threat Reduction Agency
(DTRA, Project No. D.0024_07_WR_C to Dr. N Chilukuri) from the
Department of Defense (DOD). We also thank Dr. Veeraswamy Manne for
suggestions with the preparation of the manuscript.
NR 23
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Z9 5
U1 2
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 12
PY 2010
VL 393
IS 3
BP 509
EP 513
DI 10.1016/j.bbrc.2010.02.036
PG 5
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 574GW
UT WOS:000275978400031
PM 20152811
ER
PT J
AU Li, B
Pai, R
Cardinale, SC
Butler, MM
Peet, NP
Moir, DT
Bavari, S
Bowlin, TL
AF Li, Bing
Pai, Ramdas
Cardinale, Steven C.
Butler, Michelle M.
Peet, Norton P.
Moir, Donald T.
Bavari, Sina
Bowlin, Terry L.
TI Synthesis and Biological Evaluation of Botulinum Neurotoxin A Protease
Inhibitors
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID SMALL-MOLECULE INHIBITORS; SEROTYPE-A; LIGHT-CHAIN; IDENTIFICATION;
CHEMISTRY; TOXINS; METALLOPROTEASE; RESOLUTION
AB NSC 240898 was previously identified as a botulinum neurotoxin A light chain (BoNT/A LC) endopeptidase inhibitor by screening the National Cancer Institute Open Repository diversity set. Two types of analogues have been synthesized and shown to inhibit BoNT/A LC in a FRET-based enzyme assay, with confirmation in an HPLC-based assay. These two series of compounds have also been evaluated for inhibition of anthrax lethal factor (LF), an unrelated metalloprotease, to examine enzyme specificity of the BoNT/A LC inhibition. The most potent inhibitor against BoNT/A LC in these two series is compound 12 (IC(50) = 2.5 mu M, FRET assay), which is 4.4-fold more potent than the lead structure and 11.2-fold more selective for BoNT/A LC versus the anthrax LF metalloproteinase. Structure-activity relationship studies have revealed structural features important to potency and enzyme specificity.
C1 [Li, Bing; Pai, Ramdas; Cardinale, Steven C.; Butler, Michelle M.; Peet, Norton P.; Moir, Donald T.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01605 USA.
[Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Li, B (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01605 USA.
EM bli@microbiotix.com
FU National Institutes of Health/National Institute of Allergy and
Infectious Diseases [5U01A1070430]
FX This work was supported by the National Institutes of Health/National
Institute of Allergy and Infectious Diseases (Grant 5U01A1070430). The
content of this publication does not necessarily reflect the views or
policies of the Department of Health and Human Services. The authors
thank CreaGen Biosciences, Inc. for the preparation of noncommercial
starting material 20b and for scale-up synthesis of compounds 9 and 39.
NR 32
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U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
J9 J MED CHEM
JI J. Med. Chem.
PD MAR 11
PY 2010
VL 53
IS 5
BP 2264
EP 2276
DI 10.1021/jm901852f
PG 13
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 562WT
UT WOS:000275087000032
PM 20155918
ER
PT J
AU He, HY
Pandey, R
Boustani, I
Karna, SP
AF He, Haiying
Pandey, Ravindra
Boustani, Ihsan
Karna, Shashi P.
TI Metal-like Electrical Conductance in Boron Fullerenes
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID VIBRATIONAL PROPERTIES; ELECTRONIC-PROPERTIES; LASER-ABLATION;
NANOWIRES; CLUSTERS; TRANSPORT; STABILITY; NANOTUBES; JUNCTIONS; DENSITY
AB Electron transport properties of B-fullerenes, B-80 and B-100, are investigated with the use of the first-principles density functional theory (DFT), in conjunction with the Landauer-Buttiker formalism and compared with C-fullerene, C-60, under similar conditions. The differential conductance and the tunnel Current for B-fullerenes sandwiched between Au contacts are calculated to be much higher than those for C-60. An analysis of the calculated density of states and frontier orbitals suggests Such a behavior of B-fullerenes to result from metal-like states, formed from the hybridization of ALL 6s orbital with the highest Occupied molecular orbital of B-fullerenes delocalized over the equator of the icosahedral cages, generally absent in Au-C-60-Au complex. Due to their enhanced electron transport properties, B-fullerenes appear to be attractive candidates for future nanoscale electronics.
C1 [He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
[He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Multiscale Technol Inst, Houghton, MI 49931 USA.
[Boustani, Ihsan] Univ Wuppertal, Fachbereich Theoret Chem C, D-42097 Wuppertal, Germany.
[Karna, Shashi P.] USA, Res Lab, Weapons & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
EM pandey@mtu.edu; shashi.karna@us.army.mil
FU Army Research Office [W911NF-09-1-0221]; Army Research Laboratory
[W911NF-09-2-0026]
FX The work at Michigan Technological University was performed under
support by Army Research Office through contract number W911NF-09-1-0221
and Army Research Laboratory through contract number W911NF-09-2-0026.
NR 50
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U1 0
U2 18
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD MAR 11
PY 2010
VL 114
IS 9
BP 4149
EP 4152
DI 10.1021/jp9095776
PG 4
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 562JG
UT WOS:000275045600063
ER
PT J
AU Reisler, RB
Danner, DK
Gibbs, PH
AF Reisler, Ronald B.
Danner, Denise K.
Gibbs, Paul H.
TI Immunogenicity of an inactivated Japanese encephalitis vaccine (JE-VAX)
in humans over 20 years at USAMRIID: Using PRNT50 as an endpoint for
immunogenicity
SO VACCINE
LA English
DT Article
DE Japanese encephalitis; Japanese encephalitis vaccine; Plaque-reduction
neutralization test (PRNT)
ID VIRUS; CONSULTATION; ANTIBODY; SAFETY; GENEVA
AB Two hundred and ninety-three subjects received a three-dose primary JE-VAX series and had post-primary shot 3 titers within 56 days at USAMRIID from 1985 to 2005. Overall, the PRNT50 primary response rate (titer of 1:10 or greater) was 269/293 (92%). Eighteen out of 19 subjects (95%) responded with adequate PRNT50 titer within 56 days after first JE-VAX boost. Primary PRNT50 responses to JE-VAX varied significantly in response rates and in geometric means (GMT) by vaccine lot. We recommend that future vaccine studies using PRNT as an immunologic endpoint include a coefficient of variation result alongside the GMT to assist in evaluating GMT results. For subjects who responded within 56 days of primary shot 3, 50% experienced a PRNT50 decline in titer to <1:10 at 805 days and a PRNT80 decline in titer to <1:10 at 355 days. Consequently, for individuals traveling to JE endemic areas, we recommend JE-VAX boost every 2 years and for individuals working with high titers of JE virus in the lab setting, we would recommend JE-VAX boost annually. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Reisler, Ronald B.; Danner, Denise K.; Gibbs, Paul H.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM Ronald.Reisler@amedd.army.mil
NR 19
TC 6
Z9 6
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD MAR 11
PY 2010
VL 28
IS 12
BP 2436
EP 2441
DI 10.1016/j.vaccine.2009.12.080
PG 6
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 576HN
UT WOS:000276135200011
PM 20060946
ER
PT J
AU Heinlen, LD
McClain, MT
Ritterhouse, LL
Bruner, BF
Edgerton, CC
Keith, MP
James, JA
Harley, JB
AF Heinlen, Latisha D.
McClain, Micah T.
Ritterhouse, Lauren L.
Bruner, Benjamin F.
Edgerton, Colin C.
Keith, Michael P.
James, Judith A.
Harley, John B.
TI 60 kD Ro and nRNP A Frequently Initiate Human Lupus Autoimmunity
SO PLOS ONE
LA English
DT Article
ID ANTI-SM ANTIBODIES; CLINICAL-SIGNIFICANCE; PEPTIDE IMMUNIZATION; HUMORAL
AUTOIMMUNITY; SURFACE-STRUCTURES; REVISED CRITERIA; ERYTHEMATOSUS;
AUTOANTIBODIES; DIAGNOSIS; NEPHRITIS
AB Systemic lupus erythematosus (SLE) is a clinically heterogeneous, humoral autoimmune disorder. The unifying feature among SLE patients is the production of large quantities of autoantibodies. Serum samples from 129 patients collected before the onset of SLE and while in the United States military were evaluated for early pre-clinical serologic events. The first available positive serum sample frequently already contained multiple autoantibody specificities (65%). However, in 34 SLE patients the earliest pre-clinical serum sample positive for any detectable common autoantibody bound only a single autoantigen, most commonly 60 kD Ro (29%), nRNP A (24%), anti-phospholipids (18%) or rheumatoid factor (15%). We identified several recurrent patterns of autoantibody onset using these pre-diagnostic samples. In the serum samples available, anti-nRNP A appeared before or simultaneously with anti-nRNP 70 K in 96% of the patients who had both autoantibodies at diagnosis. Anti-60 kD Ro antibodies appeared before or simultaneously with anti-La (98%) or anti-52 kD Ro (95%). The autoantibody response in SLE patients begins simply, often binding a single specific autoantigen years before disease onset, followed by epitope spreading to additional autoantigenic specificities that are accrued in recurring patterns.
C1 [Heinlen, Latisha D.; McClain, Micah T.; Ritterhouse, Lauren L.; Bruner, Benjamin F.; James, Judith A.] Oklahoma Med Res Fdn, Dept Clin Immunol, Oklahoma City, OK 73104 USA.
[Heinlen, Latisha D.; Ritterhouse, Lauren L.; James, Judith A.; Harley, John B.] Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Oklahoma City, OK USA.
[Heinlen, Latisha D.; Ritterhouse, Lauren L.; James, Judith A.; Harley, John B.] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA.
[Edgerton, Colin C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Keith, Michael P.] Natl Naval Med Ctr, Bethesda, MD USA.
[Harley, John B.] US Dept Vet Affairs, Oklahoma City, OK USA.
[Harley, John B.] Oklahoma Med Res Fdn, Dept Arthrit & Immunol, Oklahoma City, OK 73104 USA.
RP Heinlen, LD (reprint author), Oklahoma Med Res Fdn, Dept Clin Immunol, 825 NE 13th St, Oklahoma City, OK 73104 USA.
EM harley@omrf.org
FU National Institutes of Health [AI31584, AR48045, AR49084, AR45084,
AR45451, RR15577, AR48940, RR20143, AI62629, AI50350]; Kirkland Scholar
Awards; United States Department of Veterans Affairs; Lou Kerr Chair in
Biomedical Research
FX This work was supported in part by grants from the National Institutes
of Health (AI31584, AR48045, AR49084, AR45084, AR45451, RR15577,
AR48940, RR20143, AI62629, AI50350), Kirkland Scholar Awards (JBH and
JAJ) and the United States Department of Veterans Affairs. This work was
also supported in part by the Lou Kerr Chair in Biomedical Research to
JAJ. Bio-Rad provided the ANA test kits and selected the laboratory as a
beta-test site for their commercial bead based assay. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 39
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U1 1
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 10
PY 2010
VL 5
IS 3
AR e9599
DI 10.1371/journal.pone.0009599
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 565XE
UT WOS:000275328800012
PM 20224770
ER
PT J
AU Petrus, P
Lisal, M
Brennan, JK
AF Petrus, Pavel
Lisal, Martin
Brennan, John K.
TI Self-Assembly of Symmetric Diblock Copolymers in Planar Slits with and
without Nanopatterns: Insight from Dissipative Particle Dynamics
Simulations
SO LANGMUIR
LA English
DT Article
ID CHEMICALLY PATTERNED SURFACES; GRAIN-BOUNDARY MORPHOLOGY;
BLOCK-COPOLYMERS; THIN-FILMS; ADSORPTION; POLYMER
AB We present a dissipative particle dynamics simulation study on the formation of nanostructures of symmetric diblock copolymers confined between planar surfaces with and without nanopatterns. The nanopatterned surface is mimicked by alternating portions of the surface that interact differently with the diblock copolymers. The formation of the diblock-copolymer nanostructures confined between the planar surfaces is investigated and characterized by the separation width and the strength of the interaction between the surfaces and the diblock copolymers. For surfaces with nanopatterns, we also vary both the mutual area and location of the nanopatterns, where we consider nanopatterns oil the opposing surfaces that are vertically (a) aligned, (b) staggered, and (c) partially staggered. In the case of planar slits without nanopatterns, we observe the formation of perpendicular and parallel lamellar phases with different numbers of lamellae. In addition, the symmetric diblock copolymers self-assemble into adsorbed layer and adsorbed layer-parallel lamellar phases and a mixed lamellar phase when the opposing surfaces of the planar slits are modeled by different types of wall beads. In the case of nanopatterned planar slits, we observe novel nanostructures and attempt to rationalize the diblock copolymer self-assembly on the basis of the behavior that we observed in the planar slits without nanopatterns. In particular, we investigate the applicability of predicting the structures formed in the nanopatterned slits by a superposition of the observed structures in slits without nanopatterns.
C1 [Petrus, Pavel; Lisal, Martin] ASCR, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, Vvi, Prague 6, Suchdol, Czech Republic.
[Brennan, John K.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM lisal@icpf.cas.cz
RI Lisal, Martin/A-8176-2011
OI Lisal, Martin/0000-0001-8005-7143
FU Grant Agency of the Czech Republic [203/08/0094]; National Research
Programme "Information Society" [IET400720507]; Academy of Sciences of
the Czech Republic "Nanotechnology for Society" [KAN400720701]; European
Community [033304]; COST TD0802
FX This research was supported by the Grant Agency of the Czech Republic
(grant no. 203/08/0094), by the National Research Programme "Information
Society" (project no. IET400720507), by the Grant Programme of the
Academy of Sciences of the Czech Republic "Nanotechnology for Society"
(project no. KAN400720701), and by the European Community under the
sixth Framework Programme (project MULTIPRO no. 033304) and under the
seventh Framework Programme (project COST TD0802).
NR 34
TC 16
Z9 18
U1 1
U2 22
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD MAR 2
PY 2010
VL 26
IS 5
BP 3695
EP 3709
DI 10.1021/la903200j
PG 15
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA 556ZP
UT WOS:000274636900107
PM 19839566
ER
PT J
AU Roth, MJ
Eamon, CD
Slawson, TR
Tonyan, TD
Dubey, A
AF Roth, M. J.
Eamon, C. D.
Slawson, T. R.
Tonyan, T. D.
Dubey, A.
TI Ultra-High-Strength, Glass Fiber-Reinforced Concrete: Mechanical
Behavior and Numerical Modeling
SO ACI MATERIALS JOURNAL
LA English
DT Article
DE direct tension test; finite element analysis; flexural test; glass
fiber-reinforced concrete; ultra-high-strength concrete
ID DIRECT TENSION TEST; UNIAXIAL TENSION; SPECIMENS; TOUGHNESS; TESTS
AB The results of a study on the mechanical behavior of a newly developed ultra-high-strength, glass fiber-reinforced concrete (UHS-GFRC) material are presented. Third-point bending experiments, direct tension experiments, and finite element analyses were used to study the material's responses under various loading conditions, and an understanding of the tensile failure characteristics and their relationship to flexural response was developed. Elastic and post first-crack stiffness moduli were determined, as were first-crack strength and a recommended tensile failure function based on the influence of randomly distributed glass reinforcing fibers Finite element analyses using the measured tensile failure function were also used to model flexural response. and comparisons are made to the third-point bending experimental data.
C1 [Roth, M. J.] USA, Erdc, Vicksburg, MS USA.
[Eamon, C. D.] Lawrence Technol Univ, Dept Civil Engn, Southfield, MI USA.
[Slawson, T. R.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS USA.
[Tonyan, T. D.] US Gypsum Co USG, Syst Dev Struct Technol Grp, Gypsum, CO USA.
[Dubey, A.] USG Corp Innovat Ctr, US Gypsum Corp, Libertyville, IL USA.
RP Roth, MJ (reprint author), USA, Erdc, Vicksburg, MS USA.
NR 32
TC 1
Z9 1
U1 0
U2 6
PU AMER CONCRETE INST
PI FARMINGTON HILLS
PA 38800 COUNTRY CLUB DR, FARMINGTON HILLS, MI 48331 USA
SN 0889-325X
J9 ACI MATER J
JI ACI Mater. J.
PD MAR-APR
PY 2010
VL 107
IS 2
BP 185
EP 194
PG 10
WC Construction & Building Technology; Materials Science, Multidisciplinary
SC Construction & Building Technology; Materials Science
GA 610SP
UT WOS:000278756100011
ER
PT J
AU Gupta, N
Cho, K
AF Gupta, Nikhil
Cho, Kyu
TI Blast Protection Materials
SO ADVANCED MATERIALS & PROCESSES
LA English
DT Editorial Material
AB A symposium on High Strain Rate Behaviors of Composites and Heterogeneous Materials will be presented at MS&T 2010 in Houston. This is a brief introduction to the topics to be covered.
C1 [Gupta, Nikhil] NYU, Polytech Inst, Dept Mech & Aerosp Engn, Brooklyn, NY 11201 USA.
[Cho, Kyu] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Gupta, N (reprint author), NYU, Polytech Inst, Dept Mech & Aerosp Engn, Brooklyn, NY 11201 USA.
EM ngupta@poly.edu; kcho@arl.army.mil
RI Gupta, Nikhil/F-8094-2012
NR 0
TC 1
Z9 1
U1 0
U2 1
PU ASM INT
PI MATERIALS PARK
PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002
USA
SN 0882-7958
J9 ADV MATER PROCESS
JI Adv. Mater. Process.
PD MAR
PY 2010
VL 168
IS 3
BP 32
EP 33
PG 2
WC Materials Science, Multidisciplinary
SC Materials Science
GA 568XV
UT WOS:000275560400006
ER
PT J
AU Patel, SH
Bakeev, KA
Chen, G
Zhang, Q
Wan, C
AF Patel, S. H.
Bakeev, Katherine A.
Chen, Gary
Zhang, Qi
Wan, Chen
TI Determination of %Polyvinyl Alcohol in Vinyl Acetate-Alcohol Resins by
Quantitative Near Infrared Spectroscopic Analysis
SO ADVANCES IN POLYMER TECHNOLOGY
LA English
DT Article
DE Copolymer composition; Hydrolysis of VAAR; Hydroxyl content of polymers;
Near infrared spectroscopy
ID LEAST-SQUARES REGRESSION; REFLECTANCE SPECTROSCOPY; MULTIVARIATE
CALIBRATION; NIR SPECTROSCOPY; HYDROXYL VALUE; POLYESTER; POLYMERS;
NUMBER
AB A number of vinyl acetate-alcohol resins (VAAR) samples were collected during partial hydrolysis of poly(vinyl acetate) at different conversions levels (<30%). Using these VAAR samples with known OH (hydroxyl) content, it has been demonstrated that near infrared (NIR) spectroscopic data produced a near perfect fit for the calibration of OH content. A 4-factor partial least-squares method was employed and gave the best results. Further work also confirmed that NIR, operating at a well-controlled environment, is able to quantify, with great precision, the OH content of the selected model compound. In the case for the OH content analysis of VAAR resins, solvent mix ratio (methyl acetate: methanol) and temperature have been identified to be the two most influential factors on the analytical results. (C) 2010 Wiley Periodicals, Inc. Ads' Polym Techn 29: 1-10, 2010; Published online in Wiley Inter Science (www.interscience.wiley.com). DOI 10.1002/adv.20166
C1 [Patel, S. H.; Zhang, Qi] Inst Polymer Proc, Newark, NJ 07102 USA.
[Bakeev, Katherine A.] CAMO Software Inc, Woodbridge, NJ 07095 USA.
[Chen, Gary] USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
[Wan, Chen] SABIC Innovat Plast, Washington, WV 26181 USA.
RP Patel, SH (reprint author), Inst Polymer Proc, Newark, NJ 07102 USA.
EM subhash@polymers-ppi.org
FU U.S. Army Armament Research, Development and Engineering Center,
Picatinny, NJ
FX Contract grant sponsor: U.S. Army Armament Research, Development and
Engineering Center, Picatinny, NJ.
NR 21
TC 3
Z9 3
U1 1
U2 12
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0730-6679
J9 ADV POLYM TECH
JI Adv. Polym. Technol.
PD SPR
PY 2010
VL 29
IS 1
BP 1
EP 10
DI 10.1002/adv.20166
PG 10
WC Engineering, Chemical; Polymer Science
SC Engineering; Polymer Science
GA 598AZ
UT WOS:000277805600001
ER
PT J
AU Abbott, KC
Yuan, CM
AF Abbott, Kevin C.
Yuan, Cristina M.
TI The Map Is Not the Territory-Mapping Out the Course and Cost of CKD
SO AMERICAN JOURNAL OF KIDNEY DISEASES
LA English
DT Editorial Material
C1 [Abbott, Kevin C.] Walter Reed Army Med Ctr, Dialysis & Nephrol Serv, Washington, DC 20307 USA.
RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Dialysis & Nephrol Serv, 6900 Georgia Ave, Washington, DC 20307 USA.
EM kevin.abbott@us.army.mil
OI Abbott, Kevin/0000-0003-2111-7112
NR 11
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0272-6386
J9 AM J KIDNEY DIS
JI Am. J. Kidney Dis.
PD MAR
PY 2010
VL 55
IS 3
BP 419
EP 422
DI 10.1053/j.ajkd.2010.01.003
PG 4
WC Urology & Nephrology
SC Urology & Nephrology
GA 563DW
UT WOS:000275109000005
PM 20189049
ER
PT J
AU Broy, C
AF Broy, Charles
TI Computer Calls for Cardiology Consult STAT!
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Editorial Material
ID INTRAVENTRICULAR-CONDUCTION DISTURBANCES; EARLY REPOLARIZATION; ACUTE
PERICARDITIS; ELECTROCARDIOGRAM; CRITERIA
C1 [Broy, Charles] USA, Infantry Div 4, Washington, DC USA.
RP Broy, C (reprint author), 1501 Cedar Springs Circle, Clarksville, TN 37042 USA.
EM broychar@yahoo.com
NR 6
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9343
J9 AM J MED
JI Am. J. Med.
PD MAR
PY 2010
VL 123
IS 3
BP 225
EP 227
DI 10.1016/j.amjmed.2009.11.007
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 572EE
UT WOS:000275809400010
PM 20193829
ER
PT J
AU Bochicchio, GV
Kilbourne, MJ
Keledjian, K
Hess, J
Scalea, T
AF Bochicchio, Grant V.
Kilbourne, Michael J.
Keledjian, Kaspar
Hess, John
Scalea, Thomas
TI Evaluation of a New Hemostatic Agent in a Porcine Grade V Liver Injury
Model
SO AMERICAN SURGEON
LA English
DT Article
ID FIBRIN SEALANT DRESSINGS; HYPOTHERMIC COAGULOPATHIC SWINE; REDUCE
BLOOD-LOSS; RESUSCITATION VOLUME; PERIHEPATIC PACKING; IMPROVE SURVIVAL;
HEMORRHAGE; TRAUMA; EFFICACY
AB Our objective was to evaluate the hemostatic efficacy of a newly modified chitosan in a porcine grade V liver injury model. Fifteen Yorkshire pigs underwent standardized grade V liver injuries with a specially designed liver clamp and were randomized to either modified chitosan (MC) patch treatment or standard gauze packing. Free bleeding was allowed for 30 seconds. Fluid resuscitation was infused as necessary to reestablish a mean arterial pressure (MAP) within at least 80 percent of the preinjury MAR Animals were observed for 90 minutes or until death. Endpoints were survival, total blood loss, time to hemostasis, and resuscitation MAP, and resuscitation volume. Total mean blood loss was less in the MC patch group (464 +/- 267 mL vs 1234 +/- 78 mL, P < 0.001). Time to hemostasis was significantly less (4.8 +/- 2.5 minutes in the MC patch group VS 9.6 +/- 2.5 minutes, P < 0.01). Fluid resuscitation was less (1098 459 mL in the MC patch group vs 1.770 +/- 172 mL, 13 < 0.01). Survival was 100 per cent in the MC patch group and 80 per cent in the gauze packing group. MC patches demonstrate the continued hemostatic agent evolution for improved control of lethal solid organ bleeding.
C1 [Bochicchio, Grant V.; Keledjian, Kaspar; Scalea, Thomas] R Adams Cowley Shock Trauma Ctr, Div Clin & Outcomes Res, Dept Surg, Baltimore, MD 21201 USA.
[Kilbourne, Michael J.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
[Hess, John] Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA.
RP Bochicchio, GV (reprint author), R Adams Cowley Shock Trauma Ctr, Div Clin & Outcomes Res, Dept Surg, 22 S Greene St,T1R60, Baltimore, MD 21201 USA.
NR 19
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Z9 5
U1 0
U2 1
PU SOUTHEASTERN SURGICAL CONGRESS
PI ATLANTA
PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA
SN 0003-1348
J9 AM SURGEON
JI Am. Surg.
PD MAR
PY 2010
VL 76
IS 3
BP 317
EP 320
PG 4
WC Surgery
SC Surgery
GA 560VT
UT WOS:000274932700015
PM 20349664
ER
PT J
AU Kosisky, SE
Marks, MS
Nelson, MR
AF Kosisky, Susan E.
Marks, Mariko S.
Nelson, Michael R.
TI Pollen aeroallergens in the Washington, DC, metropolitan area: a 10-year
volumetric survey (1998-2007)
SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
LA English
DT Article
ID AMBROSIA-ARTEMISIIFOLIA L.; AIRBORNE POLLEN; ALLERGIC RHINITIS;
NEW-JERSEY; CALIFORNIA; COUNTS; CITY; EPIDEMIOLOGY; ASTHMA; FUNGI
AB Background: Local aeroallergen surveys identify and establish patterns of prevalence for tree, grass, and weed species that enable the clinician to more effectively select allergens for skin testing and therapy.
Objectives: To determine peak pollination periods, atmospheric concentrations, and year-to-year variation for identified tree, weed, and grass aeroallergens and examine the influence of selected meteorological parameters.
Methods: Atmospheric sampling for pollen aeroallergens was performed using a volumetric rotating-arm impaction sampler. The Spearman correlation coefficient was used to determine the relationship between daily counts and selected meteorological parameters.
Results: Previous findings for area trees, conducted at a different location, are corroborated. Predominant pollen types include Quercus, Cupressaceae, Pinaceae, Morus, Betulaceae, Acer, Platanus, Fraxinus, Poaceae, and Ambrosia. Early flowering weeds (Rumex and Typha) and Poaceae overlap with peak tree season in April. Biphasic seasons are noted for Poaceae and Ulmus. Tree pollen accounts for 91.2%, weeds 3.8%, and grasses 3.2% of total annual pollen yield. Variation in overall pollen production is evident from year to year. High production years for some species are low for others. Cyclic pollinating patterns for Alnus, Betulaceae, and Fagus were observed. Grass and weed pollen correlated positively with maximum temperature and dew point; however, the results for individual tree species were variable.
Conclusion: The Washington, DC, metropolitan area is host to a variety of tree, weed, and grass species that produce copious amounts of pollen. Further investigation into year-to-year variation with respect to inherent cycling and meteorological influences is warranted. Ann Allergy Asthma Immunol. 2010; 104:223-235.
C1 [Kosisky, Susan E.; Marks, Mariko S.; Nelson, Michael R.] Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA.
RP Kosisky, SE (reprint author), USA, Centralized Allergen Extract Lab, Bldg 512,Forest Glen Annex,9100 Brookeville Rd, Silver Spring, MD 20910 USA.
EM Susan.Kosisky@amedd.army.mil
NR 50
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Z9 18
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1081-1206
J9 ANN ALLERG ASTHMA IM
JI Ann. Allergy Asthma Immunol.
PD MAR
PY 2010
VL 104
IS 3
BP 223
EP 235
DI 10.1016/j.anai.2010.01.005
PG 13
WC Allergy; Immunology
SC Allergy; Immunology
GA 701OI
UT WOS:000285828900007
PM 20377112
ER
PT J
AU Heine, HS
Purcell, BK
Bassett, J
Miller, L
Goldstein, BP
AF Heine, Henry S.
Purcell, Bret K.
Bassett, Jennifer
Miller, Lynda
Goldstein, Beth P.
TI Activity of Dalbavancin against Bacillus anthracis In Vitro and in a
Mouse Inhalation Anthrax Model
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID AEROSOL CHALLENGE MODEL; STAPHYLOCOCCUS-AUREUS; POSTEXPOSURE
PROPHYLAXIS; BACTERICIDAL ACTIVITY; INFECTION MODEL; PHARMACOKINETICS;
GLYCOPEPTIDE; EFFICACY; RESISTANCE; SPECTRUM
AB Bacillus anthracis, the causative agent of anthrax, can produce fatal disease when it is inhaled or ingested by humans. Dalbavancin, a novel, semisynthetic lipoglycopeptide, has potent activity, greater than that of vancomycin, against Gram-positive bacteria and a half-life in humans that supports once-weekly dosing. Dalbavancin demonstrated potent in vitro activity against B. anthracis (MIC range, <= 0.03 to 0.5 mg/liter; MIC(50) and MIC(90), 0.06 and 0.25 mg/liter, respectively), which led us to test its efficacy in a murine inhalation anthrax model. The peak concentrations of dalbavancin in mouse plasma after the administration of single intraperitoneal doses of 5 and 20 mg/kg of body weight were 15 and 71 mg/kg, respectively. At 20 mg/kg, the dalbavancin activity was detectable for 6 days after administration (terminal half-life, 53 h), indicating that long intervals between doses were feasible. The mice were challenged with 50 to 100 times the median lethal dose of the Ames strain of B. anthracis, an inoculum that kills untreated animals within 4 days. The efficacy of dalbavancin was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h (q36h) or 30 to 240 mg/kg every 72 h (q72h). A regimen of ciprofloxacin known to protect 100% of animals was tested in parallel. Delayed dalbavancin treatment (beginning 36 or 48 h postchallenge) with 60 mg/kg q36h or 120 mg/kg q72h still provided 70 to 100% survival. The low MICs and long duration of efficacy in vivo suggest that dalbavancin may have potential as an alternative treatment or for the prophylaxis of B. anthracis infections.
C1 [Heine, Henry S.; Purcell, Bret K.; Bassett, Jennifer; Miller, Lynda] USA, Med Res Inst Infect Dis, Frederick, MD USA.
[Goldstein, Beth P.] Vicuron Pharmaceut, New York, NY USA.
RP Heine, HS (reprint author), Div Bacteriol, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM henry.heine@amedd.army.mil
FU Defense Threat Reduction Agency [02-4-2C-013]; Pfizer Inc.
FX The research described herein was sponsored by the Defense Threat
Reduction Agency (project no. 02-4-2C-013). B. P. G. was an employee of
Vicuron Inc., which was acquired by Pfizer Inc. after completion of this
study. B. P. G. received an honorarium from Pfizer Inc. in connection
with the development of the manuscript.; The opinions, interpretations,
conclusions, and recommendations presented here are those of the authors
and are not necessarily endorsed by the U. S. Army. Downloaded from aac.
asm. org by Institute Thomson Reuters on February 23, 2010
NR 46
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U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAR
PY 2010
VL 54
IS 3
BP 991
EP 996
DI 10.1128/AAC.00820-09
PG 6
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 558HY
UT WOS:000274733300004
PM 20047912
ER
PT J
AU Elkins, CA
Mullis, LB
Lacher, DW
Jung, CM
AF Elkins, Christopher A.
Mullis, Lisa B.
Lacher, David W.
Jung, Carina M.
TI Single Nucleotide Polymorphism Analysis of the Major Tripartite
Multidrug Efflux Pump of Escherichia coli: Functional Conservation in
Disparate Animal Reservoirs despite Exposure to Antimicrobial
Chemotherapy
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID ENTERICA SEROVAR TYPHIMURIUM; LARGE PERIPLASMIC LOOPS;
SUBSTRATE-SPECIFICITY; PHYLOGENETIC NETWORKS; MEMBRANE PROTEINS;
RESISTANCE; SALMONELLA; MUTATIONS; RECOMBINATION; TETRACYCLINE
AB AcrAB-TolC imparts a strong intrinsic resistance phenotype to many clinically significant molecules in Escherichia coli. This complex is composed of a pump, AcrB, and a periplasmic protein, AcrA, that exports substrates through a common outer membrane porin, TolC. A sequence survey of the pump-specific components, acrA and acrB, was conducted on three discrete animal reservoirs: rodents, bovines, and catfish. Although two of the reservoirs (bovine and catfish) were agrarian, and antibiotic use (ceftiofur and oxytetracycline/Romet 30, respectively) was reported for them, the vast majority of structural polymorphisms were silent except for T104A (AcrA) and Q733R (AcrB), found in certain bovine-derived strains. Overall, the genes were well conserved, with high ratios of synonymous to nonsynonymous substitutions (d(S)/d(N) ratios), consistent with or, in the case of acrB, better than those of standard multilocus sequence typing (MLST) loci. Furthermore, predicted recombination points from single nucleotide polymorphism (SNP) patterns in acrB support a modular evolution of transporter proteins, consistent with an ancient origin. However, functional studies with clones representing the major silent SNPs and the nonsilent mutation in acrB failed to generate significant differences in resistance to a range of common efflux pump substrates. Interestingly, a comparison between log-phase acrA and acrB expression profiles yielded inconsistent trends, with acrB expression increasing modestly (<1.8-fold) in many strains from the antibiotic-enriched pools. Our results suggest that structural polymorphisms in this major efflux pump system may not contribute significantly to adaptive resistance by altering function or substrate specificity but may have a potential use in improving phylogenetic relationships and/or source tracking.
C1 [Elkins, Christopher A.; Lacher, David W.] US FDA, Div Mol Biol, Ctr Food Safety & Appl Nutr, Laurel, MD 20708 USA.
[Elkins, Christopher A.; Mullis, Lisa B.; Jung, Carina M.] US FDA, Div Microbiol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.
[Jung, Carina M.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Elkins, CA (reprint author), US FDA, Div Mol Biol, Ctr Food Safety & Appl Nutr, 8301 Muirkirk Rd, Laurel, MD 20708 USA.
EM chris.elkins@fda.hhs.gov
NR 35
TC 6
Z9 6
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAR
PY 2010
VL 54
IS 3
BP 1007
EP 1015
DI 10.1128/AAC.01126-09
PG 9
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 558HY
UT WOS:000274733300006
PM 20038628
ER
PT J
AU Krakauer, T
Buckley, M
Issaq, HJ
Fox, SD
AF Krakauer, Teresa
Buckley, Marilyn
Issaq, Haleem J.
Fox, Stephen D.
TI Rapamycin Protects Mice from Staphylococcal Enterotoxin B-Induced Toxic
Shock and Blocks Cytokine Release In Vitro and In Vivo
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID REGULATORY T-CELLS; CLASS-II MOLECULES; MAMMALIAN TARGET; LETHAL SHOCK;
BACTERIAL SUPERANTIGENS; THERAPEUTIC TARGET; DENDRITIC CELLS; TRANSGENIC
MICE; HUMAN-DISEASE; ACTIVATION
AB Staphylococcal enterotoxins are potent activators for human T cells and cause lethal toxic shock. Rapamycin, an immunosuppressant, was tested for its ability to inhibit staphylococcal enterotoxin B (SEB)-induced activation of human peripheral blood mononuclear cells (PBMC) in vitro and toxin-mediated shock in mice. Stimulation of PMBC by SEB was effectively blocked by rapamycin as evidenced by the inhibition of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), IL-6, IL-2, gamma interferon (IFN-gamma), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1 alpha (MIP-1 alpha), MIP-1 beta, and T-cell proliferation. In vivo, rapamycin protected 100% of mice from lethal shock, even when administered 24 h after intranasal SEB challenge. The serum levels of MCP-1 and IL-6, after intranasal exposure to SEB, were significantly reduced in mice given rapamycin versus controls. Additionally, rapamycin diminished the weight loss and temperature fluctuations elicited by SEB.
C1 [Krakauer, Teresa; Buckley, Marilyn] USA, Med Res Inst Infect Dis, Dept Immunol, Integrated Toxicol Div, Frederick, MD 21702 USA.
[Issaq, Haleem J.; Fox, Stephen D.] Sci Applicat Int Corp Frederick Inc, Lab Prote & Analyt Technol, Frederick, MD 21702 USA.
RP Krakauer, T (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, Integrated Toxicol Div, Bldg 1425, Frederick, MD 21702 USA.
EM teresa.krakauer@amedd.army.mil
FU Defense Threat Reduction Agency
FX The views expressed in this publication are those of the author and do
not reflect the official policy or position of the Department of the
Army, the Department of Defense, or the U. S. Government.; The source of
support was the Defense Threat Reduction Agency.
NR 56
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U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAR
PY 2010
VL 54
IS 3
BP 1125
EP 1131
DI 10.1128/AAC.01015-09
PG 7
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 558HY
UT WOS:000274733300021
PM 20086156
ER
PT J
AU Whitehouse, CA
Baldwin, C
Sampath, R
Blyn, LB
Melton, R
Li, F
Hall, TA
Harpin, V
Matthews, H
Tediashvili, M
Jaiani, E
Kokashvili, T
Janelidze, N
Grim, C
Colwell, RR
Huq, A
AF Whitehouse, Chris A.
Baldwin, Carson
Sampath, Rangarajan
Blyn, Lawrence B.
Melton, Rachael
Li, Feng
Hall, Thomas A.
Harpin, Vanessa
Matthews, Heather
Tediashvili, Marina
Jaiani, Ekaterina
Kokashvili, Tamar
Janelidze, Nino
Grim, Christopher
Colwell, Rita R.
Huq, Anwar
TI Identification of Pathogenic Vibrio Species by Multilocus
PCR-Electrospray Ionization Mass Spectrometry and Its Application to
Aquatic Environments of the Former Soviet Republic of Georgia
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID CHOLERAE
AB The Ibis T5000 is a novel diagnostic platform that couples PCR and mass spectrometry. In this study, we developed an assay that can identify all known pathogenic Vibrio species and field-tested it using natural water samples from both freshwater lakes and the Georgian coastal zone of the Black Sea. Of the 278 total water samples screened, 9 different Vibrio species were detected, 114 (41%) samples were positive for V. cholerae, and 5 (0.8%) samples were positive for the cholera toxin A gene (ctxA). All ctxA-positive samples were from two freshwater lakes, and no ctxA-positive samples from any of the Black Sea sites were detected.
C1 [Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA.
[Sampath, Rangarajan; Blyn, Lawrence B.; Melton, Rachael; Li, Feng; Hall, Thomas A.; Harpin, Vanessa; Matthews, Heather] Ibis Biosci, Carlsbad, CA USA.
[Tediashvili, Marina; Jaiani, Ekaterina; Kokashvili, Tamar; Janelidze, Nino] G Eliava Inst Bacteriophage Microbiol & Virol, Tbilisi, Rep of Georgia.
[Grim, Christopher; Colwell, Rita R.; Huq, Anwar] Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA.
[Colwell, Rita R.] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA.
RP Whitehouse, CA (reprint author), USA, Med Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Frederick, MD 21702 USA.
EM chris.whitehouse@us.army.mil
FU U.S. Defense Threat Reduction Agency (DTRA) [GG-13]; IC [HM15820612010]
FX This research was supported, in part, by the U.S. Defense Threat
Reduction Agency (DTRA) Cooperative Threat Reduction Program (project
GG-13). C. Grim was supported by an IC Postdoctoral Research Fellowship
(NGA grant HM15820612010).
NR 10
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U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD MAR
PY 2010
VL 76
IS 6
BP 1996
EP 2001
DI 10.1128/AEM.01919-09
PG 6
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 564DQ
UT WOS:000275193900033
PM 20118359
ER
PT J
AU Blue, MA
Ntuen, C
Letowski, T
AF Blue, Misty A.
Ntuen, Celestine
Letowski, Tomasz
TI Speech intelligibility measured with shortened versions of Callsign
Acquisition Test (CAT)
SO APPLIED ERGONOMICS
LA English
DT Article
DE Callsign Acquisition Test (CAT); Speech intelligibility testing;
Predictive power
ID WORD RECOGNITION
AB The Callsign Acquisition Test (CAT) is a new speech intelligibility test developed by the Human Research and Engineering Directorate of the U.S. Army Research Laboratory (ARL-HRED). CAT uses the phonetic alphabet and digit stimuli combined together to form 126 test items.
Objective: The purpose of this study was to assess the reliability of data collected with shorter versions of CAT.
Design: A total of 5 shorter versions of the original list (CAT-120, CAT-60, CAT-40, CAT-30, and CAT-24) were formed and evaluated using 19 participants. Each of the subsets of CAT was presented in pink noise at signal-to-noise ratios (SNRs) of -6 dB and -9 dB.
Results: Results showed that shortened CAT lists have the capability of providing the same predictive power as the full CAT with good test-retest reliability.
Conclusions: Under the experimental conditions of this study, any of the shorter versions of the CAT can be utilized in place of the full version to reduce testing times with no effect on predictive power. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Blue, Misty A.] Wright State Univ, Dept Biomed Ind & Human Factors Engn, Dayton, OH 45435 USA.
[Ntuen, Celestine] N Carolina Agr & Tech State Univ, Dept Ind & Syst Engn, Greensboro, NC 27411 USA.
[Letowski, Tomasz] USA, Res Lab, Human Res & Engn Directorate, Aberdeen, MD USA.
RP Blue, MA (reprint author), Wright State Univ, Dept Biomed Ind & Human Factors Engn, 240 Russ Engn Ctr,3640 Colonel Glenn Highway, Dayton, OH 45435 USA.
EM misty.blue@wright.edu
FU United States Army Research Laboratory - Human Research and Engineering
Directorate in Aberdeen Proving Grounds, Maryland
FX This work was funded by the United States Army Research Laboratory -
Human Research and Engineering Directorate in Aberdeen Proving Grounds,
Maryland.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0003-6870
J9 APPL ERGON
JI Appl. Ergon.
PD MAR
PY 2010
VL 41
IS 2
BP 291
EP 294
DI 10.1016/j.apergo.2009.07.011
PG 4
WC Engineering, Industrial; Ergonomics; Psychology, Applied
SC Engineering; Psychology
GA 527YD
UT WOS:000272406300014
PM 19748610
ER
PT J
AU Maloney, PG
Smith, P
King, V
Billman, C
Winkler, M
Mazur, E
AF Maloney, Patrick G.
Smith, Peter
King, Vernon
Billman, Curtis
Winkler, Mark
Mazur, Eric
TI Emissivity of microstructured silicon
SO APPLIED OPTICS
LA English
DT Article
ID FEMTOSECOND-LASER-PULSES
AB Infrared transmittance and hemispherical-directional reflectance data from 2.5 to 25 mu m on microstructured silicon surfaces have been measured, and spectral emissivity has been calculated for this wavelength range. Hemispherical-total emissivity is calculated for the samples and found to be 0.84 before a measurement-induced annealing and 0.65 after the measurement for the sulfur-doped sample. Secondary samples lack a measurement-induced anneal, and reasons for this discrepancy are presented. Emissivity numbers are plotted and compared with a silicon substrate, and Aeroglaze Z306 black paint. Use of microstructured silicon as a blackbody or microbolometer surface is modeled and presented, respectively. (C) 2010 Optical Society of America
C1 [Maloney, Patrick G.; Smith, Peter; King, Vernon; Billman, Curtis] USA, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Res Dev & Engn Command,Sci & Technol Div, Ft Belvoir, VA 22060 USA.
[Winkler, Mark; Mazur, Eric] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA.
RP Maloney, PG (reprint author), USA, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Res Dev & Engn Command,Sci & Technol Div, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA.
EM info@nvl.army.mil
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U1 0
U2 19
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD MAR 1
PY 2010
VL 49
IS 7
BP 1065
EP 1068
DI 10.1364/AO.49.001065
PG 4
WC Optics
SC Optics
GA 566RF
UT WOS:000275390000008
PM 20197803
ER
PT J
AU Liu, L
Dharne, M
Kannan, P
Smith, A
Meng, JH
Fan, MT
Boren, TL
Ranallo, RT
Bhagwat, AA
AF Liu, Liu
Dharne, Mahesh
Kannan, Porteen
Smith, Allen
Meng, Jianghong
Fan, Mingtao
Boren, Tara L.
Ranallo, Ryan T.
Bhagwat, Arvind A.
TI Osmoregulated periplasmic glucans synthesis gene family of Shigella
flexneri
SO ARCHIVES OF MICROBIOLOGY
LA English
DT Article
DE Periplasmic glucans; Low osmolarity; Food- and water-borne Shigellosis
ID ENTERICA SEROVAR TYPHIMURIUM; ESCHERICHIA-COLI; BIOSYNTHESIS;
OLIGOSACCHARIDES; RESISTANCE; PROTEIN; MICE
AB Osmoregulated periplasmic glucans (OPGs) of food- and water-borne enteropathogen Shigella flexneri were characterized. OPGs were composed of 100% glucose with 2-linked glucose as the most abundant residue with terminal glucose, 2-linked and 2,6-linked glucose also present in high quantities. Most dominant backbone polymer chain length was seven glucose residues. Individual genes from the opg gene family comprising of a bicistronic operon opgGH, opgB, opgC and opgD were mutagenized to study their effect on OPGs synthesis, growth in hypo-osmotic media and ability to invade HeLa cells. Mutation in opgG and opgH abolished OPGs biosynthesis, and mutants experienced longer lag time to initiate growth in hypo-osmotic media. Longer lag times to initiate growth in hypo-osmotic media were also observed for opgC and opgD mutants but not for opgB mutant. All opg mutants were able to infect HeLa cells, and abolition of OPGs synthesis did not affect actin polymerization or plaque formation. Ability to synthesize OPGs was beneficial to bacteria in order to initiate growth under low osmolarity conditions, in vitro mammalian cell invasion assays, however, could not discriminate whether OPGs were required for basic aspect of Shigella virulence.
C1 [Liu, Liu; Dharne, Mahesh; Kannan, Porteen; Bhagwat, Arvind A.] ARS, Environm Microbial & Food Safety Lab, Henry A Wallace Beltsville Agr Res Ctr, USDA, Beltsville, MD 20705 USA.
[Liu, Liu; Fan, Mingtao] NW A&F Univ, Coll Food Sci & Technol, Yangling 712100, Peoples R China.
[Smith, Allen] ARS, Diet Genom & Immunol Lab, Henry A Wallace Beltsville Agr Res Ctr, USDA, Beltsville, MD 20705 USA.
[Liu, Liu; Meng, Jianghong] Univ Maryland, Dept Food Sci & Nutr, College Pk, MD 20742 USA.
[Boren, Tara L.; Ranallo, Ryan T.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA.
RP Bhagwat, AA (reprint author), ARS, Environm Microbial & Food Safety Lab, Henry A Wallace Beltsville Agr Res Ctr, USDA, 10300 Baltimore Ave,Bldg 002,BARC W, Beltsville, MD 20705 USA.
EM arvind.bhagwat@ars.usda.gov
RI Dharne, Mahesh/K-3541-2012;
OI Kannan, Porteen/0000-0002-6925-328X
FU China Scholarship Council; Ministry of Education, China
FX The study was supported in part by the China Scholarship Council,
Ministry of Education, China (LL). We would like to thank Malabi
Venkatesan for support of this project. The content of this publication
does not necessarily reflect the views or policies of the US Department
of the Army, US Department of Agriculture or the US Department of
Defense nor does the mention of trade names, commercial products, or
organizations imply endorsement by the US Government.
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U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0302-8933
J9 ARCH MICROBIOL
JI Arch. Microbiol.
PD MAR
PY 2010
VL 192
IS 3
BP 167
EP 174
DI 10.1007/s00203-009-0538-z
PG 8
WC Microbiology
SC Microbiology
GA 554SV
UT WOS:000274455600003
PM 20062978
ER
PT J
AU Nadeau, DP
Rich, JN
Brietzke, SE
AF Nadeau, Daniel P.
Rich, Jeremy N.
Brietzke, Scott E.
TI Informed Consent in Pediatric Surgery Do Parents Understand the Risks?
SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
LA English
DT Article
ID NECK-SURGERY; OTITIS-MEDIA; INFANTS; HEAD
AB Objective: To investigate parent understanding of the risks of pediatric ear, nose, and throat surgery after counseling with and Without the use of informational aids.
Design: Prospective, randomized trial.
Setting: Academic tertiary care center
Participants: Parents of children undergoing car, nose, and throat surgery.
Interventions: Parents were randomized to receive standard informed consent with or without detailed information aids.
Main Outcome Measures: Parents completed identical questionnaires testing their general procedure knowledge and their recall of 9 specific surgical risks both immediately after counseling and on the day of surgery.
Results: Thirty-four parents enrolled in and completed the study (18 in the control group and 1.6 in the test group). The mean time from informed consent to surgery was 6.3 days (range, 1-22 days). Parents in the test group scored significantly higher on identifying the 9 risks on both the preoperative questionnaire (mean score, 6.00 vs 4.44; P=.007, 2-tailed t test) and the postoperative questionnaire (6.25 vs 4.17; P<.001). There was a negative correlation (inverse relationship) between parent education score and risk recall, with parents with lower education levels scoring higher on both the preoperative (Pearson r=-0.36; P=.04) and the postoperative (r=-0.35; P=.04) surveys. The maternal parent recalled risks significantly better than the paternal parent, with surgical risk recall scores of 5.46 out of 9 vs 3.67 Out Of 9 (P=.02, 2-tailed t test).
Conclusions: Parents of children undergoing car, nose, and throat surgery recall far less than 100% of courseled risks. The use of detailed surgical risk counseling improves measured parental understanding Of Surgical risk. Parental educational level and maternal vs paternal parent may affect risk counseling recall.
C1 [Nadeau, Daniel P.; Rich, Jeremy N.; Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20307 USA.
RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 6900 Georgia Ave, Washington, DC 20307 USA.
EM scott.brietzke@amedd.army.mil
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U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0886-4470
J9 ARCH OTOLARYNGOL
JI Arch. Otolaryngol. Head Neck Surg.
PD MAR
PY 2010
VL 136
IS 3
BP 265
EP 269
PG 5
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA 569FI
UT WOS:000275581600009
PM 20231645
ER
PT J
AU Reed, J
Mans, CK
Brietzke, SE
AF Reed, Jeremy
Mans, Carolyn K.
Brietzke, Scott E.
TI Statistics or Ethics? Decision to Treat Drooling Reply
SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
LA English
DT Letter
C1 [Reed, Jeremy; Mans, Carolyn K.; Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA.
RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, 6900 Georgia Ave, Washington, DC 20307 USA.
EM scott.brietzke@amedd.army.rnil
OI Brietzke, Scott/0000-0002-2844-6026
NR 2
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U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0886-4470
J9 ARCH OTOLARYNGOL
JI Arch. Otolaryngol. Head Neck Surg.
PD MAR
PY 2010
VL 136
IS 3
BP 315
EP 316
PG 2
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA 569FI
UT WOS:000275581600023
ER
PT J
AU Yildirim, ED
Besunder, R
Pappas, D
Allen, F
Guceri, S
Sun, W
AF Yildirim, Eda D.
Besunder, Robyn
Pappas, Daphne
Allen, Fred
Guceri, Selcuk
Sun, Wei
TI Accelerated differentiation of osteoblast cells on polycaprolactone
scaffolds driven by a combined effect of protein coating and plasma
modification
SO BIOFABRICATION
LA English
DT Article
ID FIBRONECTIN CONFORMATION; TISSUE SCAFFOLDS; PROLIFERATION; ADHESION;
DEPOSITION; BIOMATERIALS; ATTACHMENT; PHENOTYPE; FIBER
AB A combined effect of protein coating and plasma modification on the quality of the osteoblast-scaffold interaction was investigated. Three-dimensional polycaprolactone (PCL) scaffolds were manufactured by the precision extrusion deposition (PED) system. The structural, physical, chemical and biological cues were introduced to the surface through providing 3D structure, coating with adhesive protein fibronectin and modifying the surface with oxygen-based plasma. The changes in the surface properties of PCL after those modifications were examined by contact angle goniometry, surface energy calculation, surface chemistry analysis (XPS) and surface topography measurements (AFM). The effects of modification techniques on osteoblast short-term and long-term functions were examined by cell adhesion, proliferation assays and differentiation markers, namely alkaline phosphatase activity (ALP) and osteocalcin secretion. The results suggested that the physical and chemical cues introduced by plasma modification might be sufficient for improved cell adhesion, but for accelerated osteoblast differentiation the synergetic effects of structural, physical, chemical and biological cues should be introduced to the PCL surface.
C1 [Yildirim, Eda D.; Guceri, Selcuk; Sun, Wei] Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA.
[Besunder, Robyn; Allen, Fred] Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USA.
[Pappas, Daphne] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Yildirim, ED (reprint author), Drexel Univ, Dept Mech Engn & Mech, 3141 Chestnut St, Philadelphia, PA 19104 USA.
EM edy22@drexel.edu
OI Pappas, Daphne/0000-0002-5746-8873
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U1 2
U2 14
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1758-5082
EI 1758-5090
J9 BIOFABRICATION
JI Biofabrication
PD MAR
PY 2010
VL 2
IS 1
AR 014109
DI 10.1088/1758-5082/2/1/014109
PG 12
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 602DJ
UT WOS:000278118400010
PM 20811124
ER
PT J
AU Hari, PN
Majhail, NS
Zhang, MJ
Hassebroek, A
Siddiqui, F
Ballen, K
Bashey, A
Bird, J
Freytes, CO
Gibson, J
Hale, G
Holmberg, L
Kamble, R
Kyle, RA
Lazarus, HM
LeMaistre, CF
Loberiza, F
Maiolino, A
McCarthy, PL
Milone, G
Omondi, N
Reece, DE
Seftel, M
Trigg, M
Vesole, D
Weiss, B
Wiernik, P
Lee, SJ
Rizzo, JD
Mehta, P
AF Hari, Parameswaran N.
Majhail, Navneet S.
Zhang, Mei-Jie
Hassebroek, Anna
Siddiqui, Fareeha
Ballen, Karen
Bashey, Asad
Bird, Jenny
Freytes, Cesar O.
Gibson, John
Hale, Gregaory
Holmberg, Leona
Kamble, Ram
Kyle, Robert A.
Lazarus, Hillard M.
LeMaistre, Charles F.
Loberiza, Fausto
Maiolino, Angelo
McCarthy, Philip L.
Milone, Gustavo
Omondi, Nancy
Reece, Donna E.
Seftel, Matthew
Trigg, Michael
Vesole, David
Weiss, Brendan
Wiernik, Peter
Lee, Stephanie J.
Rizzo, J. Douglas
Mehta, Paulette
TI Race and Outcomes of Autologous Hematopoietic Cell Transplantation for
Multiple Myeloma
SO BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
LA English
DT Article
DE Autologous hematopoietic cell transplantation; Multiple myeloma; Race;
Survival; Progression-free survival
ID AFRICAN-AMERICAN PATIENTS; UNITED-STATES VETERANS; UNDETERMINED
SIGNIFICANCE; MONOCLONAL GAMMOPATHY; SOCIOECONOMIC-STATUS; SURVIVAL;
CANCER; CHEMOTHERAPY; WHITE; RISK
AB Blacks are twice as likely to develop and die from multiple myeloma (MM), and are less likely to receive an autologous hematopoietic-cell transplant (AHCT) for MM compared to Whites. The influence of race on outcomes of AHCT for MM is not well described. We compared the probability of overall survival (OS), progression-free survival (PFS), disease progression, and nonrelapse mortality (NRM) among Black (N = 303) and White (N = 1892) recipients of AHCT for MM, who were reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) from 1995 to 2005. The Black cohort was more likely to be female, and had better Karnofsky performance scores, but lower hemoglobin and albumin levels at diagnosis. Black recipients were younger and more likely to be transplanted later in their disease course. Disease stage and treatment characteristics prior to AHCT were similar between the 2 groups. Black and White recipients had similar probabilities of 5-year OS (52% versus 47%, P = .19) and PFS (19% versus 21%, P = .64) as well as cumulative incidences of disease progression (72% versus 72%, P = .97) and NRM (9% versus 8%, P = .52). In multivariate analyses, race was not associated with any of these endpoints. Black recipients of AHCT for MM have similar outcomes compared to Whites, suggesting that the reasons underlying lower rates of AHCT in Blacks need to be studied further to ensure equal access to effective therapy. Biol Blood Marrow Transplant 16: 395-402 (2010) (C) 2010 American Society for Blood and Marrow Transplantation
C1 [Hari, Parameswaran N.; Zhang, Mei-Jie; Lee, Stephanie J.; Rizzo, J. Douglas] Med Coll Wisconsin, CIBMTR, Milwaukee, WI 53226 USA.
[Majhail, Navneet S.; Hassebroek, Anna] Ctr Int Blood & Marrow Transplant Res, Natl Marrow Donor Program, Minneapolis, MN USA.
[Majhail, Navneet S.] Univ Minnesota, Minneapolis, MN USA.
[Ballen, Karen] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Bashey, Asad] Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.
[Bird, Jenny] Bristol Haematol & Oncol Ctr, Bristol, Avon, England.
[Freytes, Cesar O.] S Texas Vet Hlth Care Syst, San Antonio, TX USA.
[Freytes, Cesar O.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Gibson, John] Royal Prince Alfred Hosp, Camperdown, NSW 2050, Australia.
[Hale, Gregaory] Childrens Hosp, St Petersburg, FL USA.
[Holmberg, Leona] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Kamble, Ram] Baylor Coll Med, Houston, TX 77030 USA.
[Kyle, Robert A.] Mayo Clin, Rochester, MN USA.
[Lazarus, Hillard M.] Univ Hosp Cleveland, Case Med Ctr, Cleveland, OH 44106 USA.
[LeMaistre, Charles F.] Texas Transplant Inst, San Antonio, TX USA.
[Loberiza, Fausto] Univ Nebraska Med Ctr, Omaha, NE USA.
[Maiolino, Angelo] Hosp Univ Clementino Frago Filho, Rio De Janeiro, Brazil.
[McCarthy, Philip L.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA.
[Milone, Gustavo] Angelica Ocampo Hosp & Res Ctr, Fundaleu Buenos Aires, Argentina.
[Reece, Donna E.] Univ Toronto, Toronto, ON, Canada.
[Seftel, Matthew] CancerCare Manitoba, Morden, MB, Canada.
[Trigg, Michael] Merck & Co Inc, Wilmington, DE USA.
[Vesole, David] Loyola Univ Hlth Syst, Maywood, IL USA.
[Weiss, Brendan] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Wiernik, Peter] New York Med Coll, Bronx, NY USA.
[Mehta, Paulette] Univ Arkansas, Little Rock, AR 72204 USA.
RP Hari, PN (reprint author), Med Coll Wisconsin, CIBMTR, POB 26509,8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.
EM phari@mcw.edu
OI Hari, Parameswaran/0000-0002-8800-297X
FU National Cancer Institute (NCI) [U24-CA76518]; National Heart, Lung and
Blood Institute (NHLBI) [5U01HL069294]; National Institute of Allergy
and Infectious Diseases (NIAID); Health Resources and Services
Administration (HRSA/DHHS) [HHSH234200637015C]; Office of Naval Research
[N00014-06-1-0704, N00014-08-1-0058]; AABB; Aetna; American Society for
Blood and Marrow Transplantation; Amgen, Inc.
FX The CIBMTR is supported by Public Health Service Grant/Cooperative
Agreement U24-CA76518 from the National Cancer Institute (NCI), the
National Heart, Lung and Blood Institute (NHLBI), and the National
Institute of Allergy and Infectious Diseases (NIAID); a
Grant/Cooperative Agreement 5U01HL069294 from NHLBI and NCI; a contract
HHSH234200637015C with Health Resources and Services Administration
(HRSA/DHHS); 2 Grants N00014-06-1-0704 and N00014-08-1-0058 from the
Office of Naval Research; and grants from AABB; Aetna; American Society
for Blood and Marrow Transplantation; Amgen, Inc.; anonymous donation to
the Medical College of Wisconsin; Association of Medical Microbiology
and Infectious Disease Canada; Astellas Pharma US, Inc.; Baxter
International, Inc.; Bayer HealthCare Pharmaceuticals; Blood Center of
Wisconsin; Blue Cross and Blue Shield Association; Bone Marrow
Foundation; Canadian Blood and Marrow Transplant Group; Celgene
Corporation; CellGenix, GmbH; Centers for Disease Control and
Prevention; ClinImmune Labs; CTI Clinical Trial and Consulting Services;
Cubist Pharmaceuticals; Cylex Inc.; CytoTherm; DOR BioPharma, Inc.;
Dynal Biotech, an Invitrogen Company; Enzon Pharmaceuticals, Inc.;
European Group for Blood and Marrow Transplantation; Gambro BCT, Inc.;
Gamida Cell, Ltd.; Genzyme Corporation; Histogenetics, Inc.; HKS Medical
Information Systems; Hospira, Inc.; Infectious Diseases Society of
America; Kiadis Pharma; Kirin Brewery Co., Ltd.; Merck & Company; The
Medical College of Wisconsin; MGI Pharma, Inc.; Michigan Community Blood
Centers; Millennium Pharmaceuticals, Inc.; Miller Pharmacal Group;
Milliman USA, Inc.; Miltenyi Biotec, Inc.; National Marrow Donor
Program; Nature Publishing Group; New York Blood Center; Novartis
Oncology; Oncology Nursing Society; Osiris Therapeutics, Inc.; Otsuka
Pharmaceutical Development & Commercialization, Inc.; Pall Life
Sciences; PDL BioPharma, Inc; Pfizer Inc; Pharmion Corporation; Saladax
Biomedical, Inc.; Schering Plough Corporation; Society for Healthcare
Epidemiology of America; StemCyte, Inc.; StemSoft Software, Inc.;
Sysmex; Teva Pharmaceutical Industries; The Marrow Foundation; THERAKOS,
Inc.; Vidacare Corporation; Vion Pharmaceuticals, Inc.; ViraCor
Laboratories; ViroPharma, Inc.; and Wellpoint, Inc.
NR 28
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U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1083-8791
EI 1523-6536
J9 BIOL BLOOD MARROW TR
JI Biol. Blood Marrow Transplant.
PD MAR
PY 2010
VL 16
IS 3
BP 395
EP 402
DI 10.1016/j.bbmt.2009.11.007
PG 8
WC Hematology; Immunology; Transplantation
SC Hematology; Immunology; Transplantation
GA 584DO
UT WOS:000276730800012
PM 19922808
ER
PT J
AU Du, YN
Hancock, MJ
He, JK
Villa-Uribe, JL
Wang, B
Cropek, DM
Khademhosseini, A
AF Du, Yanan
Hancock, Matthew J.
He, Jiankang
Villa-Uribe, Jose L.
Wang, Ben
Cropek, Donald M.
Khademhosseini, Ali
TI Convection-driven generation of long-range material gradients
SO BIOMATERIALS
LA English
DT Article
DE Anisotropic materials; Composite materials; Microfluidics; Gradients
ID RECTANGULAR CONDUITS; FLUORESCENCE RECOVERY; MICROFLUIDIC DEVICE;
LAMINAR DISPERSION; HYALURONIC-ACID; SELF-DIFFUSION; CELL-GROWTH;
CHEMOTAXIS; SCAFFOLDS; FLOWS
AB Natural materials exhibit anisotropy with variations in soluble factors, cell distribution, and matrix properties The ability to recreate the heterogeneity of the natural materials is a major challenge for investigating cell-material interactions and for developing biomimetic: materials Here we present a generic fluidic approach using convection and alternating flow to rapidly generate multi-centimeter gradients of biomolecules, polymers, beads and cells and cross-gradients of two species in a microchannel. Accompanying theoretical estimates and simulations of gradient growth provide design criteria over a range of material properties A poly(ethylene-glycol) hydrogel gradient. a Porous collagen gradient and a composite material with a hyaluronic acid/gelatin cross-gradient were generated with continuous variations in material properties and in their ability to regulate cellular response This simple yet generic fluidic platform should prove useful for creating anisotropic biomimetic materials and high-throughput platforms for investigating cell-microenvironment interactions (C) 2009 Elsevier Ltd All rights reserved.
C1 [Du, Yanan; Hancock, Matthew J.; He, Jiankang; Villa-Uribe, Jose L.; Wang, Ben; Khademhosseini, Ali] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Ctr Biomed Engn, Cambridge, MA 02139 USA.
[Du, Yanan; Hancock, Matthew J.; He, Jiankang; Villa-Uribe, Jose L.; Wang, Ben; Khademhosseini, Ali] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
[He, Jiankang] Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Shaanxi, Peoples R China.
[Cropek, Donald M.] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA.
RP Khademhosseini, A (reprint author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Ctr Biomed Engn, Cambridge, MA 02139 USA.
RI Hancock, Matthew/G-3859-2010; Khademhosseini, Ali/A-9435-2010; Wang,
Ben/B-6488-2011;
OI Hancock, Matthew/0000-0001-9820-3620; Khademhosseini,
Ali/0000-0002-2692-1524; Wang, Ben/0000-0002-4134-1835; Khademhosseini,
Ali/0000-0001-6322-8852
FU US Army Engineer Research and Development Center; Institute for Soldier
Nanotechnology; NIH [HL092836, DE019024, EB007249]; National Science
Foundation; China Scholarship Council (CSC); Program for Changjiang
Scholars and Innovative Research Team in University, China [IRT0646]
FX This research was funded by the US Army Engineer Research and
Development Center, the Institute for Soldier Nanotechnology, the NIH
(HL092836, DE019024. EB007249), and the National Science Foundation
CAREER award (AK). YD was supported by an appointment to the
postgraduate research participation program at the US Army Engineer
Research and Development Center, Construction Engineering Research
Laboratory (ERDC-CERL), administered by the Oak Ridge Institute for
Science and Education JH was partially sponsored by the China
Scholarship Council (CSC), the Program for Changjiang Scholars and
Innovative Research Team in University (IRT0646), China. Comsol was
provided through the CrimsonGrid initiative at Harvard University. We
would like to thank Dr. Jaesool Shim, Dr. Jason Nichol, Dr. Lianyong
Wang, and Dr Ian Wheeldon for scientific and technical support.
NR 35
TC 41
Z9 41
U1 5
U2 29
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0142-9612
J9 BIOMATERIALS
JI Biomaterials
PD MAR
PY 2010
VL 31
IS 9
BP 2686
EP 2694
DI 10.1016/j.biomaterials.2009.12.012
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 566CX
UT WOS:000275348800026
PM 20035990
ER
PT J
AU Park, JP
Cropek, DM
Banta, S
AF Park, Jong Pil
Cropek, Donald M.
Banta, Scott
TI High Affinity Peptides for the Recognition of the Heart Disease
Biomarker Troponin I Identified Using Phage Display
SO BIOTECHNOLOGY AND BIOENGINEERING
LA English
DT Article
DE troponin I; phage display; cardiac biomarker; peptide recognition
sequences; homolog specificity
ID BIOLOGICAL THREAT AGENTS; MYOCARDIAL-INFARCTION; MOLECULAR RECOGNITION;
CARDIAC INJURY; PROTEIN; ASSAY; LIBRARIES; TECHNOLOGIES; ELECTRODES;
LIGANDS
AB Troponin I is a specific and sensitive clinical biomarker for myocardial injury. In this Study we have used polyvalent phage display to isolate unique linear peptide motifs which recognize both the human and rat homologs of troponin I. The peptide specific for human troponin I has a sequence of FYSHSFHENWPS and the peptide specific for the rat troponin I has a sequence of FHSSWPVNGSTI. Enzyme-linked immunosorbent assays (ELISAs) were used to evaluate the binding interactions, and the two phage-displayed peptides exhibited some cross-reactivity, but they were both more specific for the troponin I homolog they were selected against. The binding affinities of the phage-displayed peptides were decreased by the presence of complex tissue culture media (MEM), and the addition of 10% calf serum further interfered with the binding of the target proteins. Kinetic indirect phage ELISAs revealed that both troponin I binding peptides were found to have nanomolar affinities for the troponin proteins while attached to the phage particles. To our knowledge, this is the first example of isolation and characterization of troponin I binders using phage display technology. These new peptides may have potential utility in the development of new clinical assays for cardiac injury as well as in monitoring of cardiac cells grown in culture. Biotechnol. Bioeng. 2010;105: 678-686. (C) 2009 Wiley Periodicals, Inc.
C1 [Park, Jong Pil; Banta, Scott] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA.
[Cropek, Donald M.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61824 USA.
RP Banta, S (reprint author), Columbia Univ, Dept Chem Engn, 500 W 120th St, New York, NY 10027 USA.
EM sbanta@cheme.columbia.edu
FU U.S. Army [W9132T-07-2-0008, W9132T-08-2-0002]; CERL; Oak Ridge
Institute for Science and Engineering
FX Contract grant sponsor: U.S. Army Basic Research Program Contract grant
number: W9132T-07-2-0008; W9132T-08-2-0002; Funding was provided by the
U.S. Army Basic Research Program and Columbia University was supported
by the U.S. Army, CERL, Agreement No. W9132T-07-2-0008 and Agreement No.
W9132T-08-20002. J.P. Park is grateful to CERL and the Oak Ridge
Institute for Science and Engineering program for support.
NR 47
TC 29
Z9 29
U1 10
U2 31
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0006-3592
J9 BIOTECHNOL BIOENG
JI Biotechnol. Bioeng.
PD MAR 1
PY 2010
VL 105
IS 4
BP 678
EP 686
DI 10.1002/bit.22597
PG 9
WC Biotechnology & Applied Microbiology
SC Biotechnology & Applied Microbiology
GA 558KX
UT WOS:000274742200002
PM 19891006
ER
PT J
AU Wehrum, MJ
Hines, JF
Hayes, EB
Kost, ER
Hall, KL
Paidas, MJ
AF Wehrum, Mark J.
Hines, Jeffrey F.
Hayes, Edwin B.
Kost, Edward R.
Hall, Kevin L.
Paidas, Michael J.
TI Comparative assessment of hypercoagulability in women with and without
gynecologic malignancies using the thromboelastograph coagulation
analyzer
SO BLOOD COAGULATION & FIBRINOLYSIS
LA English
DT Article
DE gynecologic malignancies; hypercoagulability; thromboelastograph
coagulation analyzer
ID CANCER-PATIENTS
AB The hypercoagulability status of women with and without gynecologic malignancies was compared using the thromboelastograph coagulation analyzer. Blood specimens from 25 women with newly diagnosed gynecologic malignancies and from 21 age-matched controls were analyzed. Hypercoagulability is defined by a short R value (min), a short K value (min), an elevated maximum amplitude (MA) value (mm), and a broad alpha-angle (degrees). A two-tailed, two-sample t-test was used for statistical analysis. When compared with specimens from age-matched controls, specimens from women with gynecologic malignancies demonstrated values consistent with hypercoagulability. The specific parameters are presented as a mean (+/- SD). Patients with gynecologic malignancies were found to have a short R value (7.1 +/- 2.1 vs. 11.8 +/- 1.8 min; P<0.001), a short K value (3.1 +/- 0.9 vs. 4.6 +/- 0.9 min; P<0.001), a prolonged MA value (64.7 +/- 5.4 vs. 58.8 +/- 6.1 mm; P=0.001), and a greater alpha-angle (70.6 +/- 5.3 vs. 61.6 +/- 4.90; P<0.001). Detection of hypercoagulability as measured by thromboelastography is statistically more common among women with gynecologic malignancies compared with age-matched controls. Future studies may address the use of thromboelastography to identify patients at risk for gynecologic malignancies. Blood Coagul Fibrinolysis 21:140-143 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Wehrum, Mark J.; Paidas, Michael J.] Yale Univ, Div Maternal Fetal Med, Dept Obstet Gynecol & Reprod Sci, Yale Women & Childrens Ctr Blood Disorders, New Haven, CT 06520 USA.
[Wehrum, Mark J.; Hines, Jeffrey F.; Hayes, Edwin B.; Kost, Edward R.; Hall, Kevin L.] Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Houston, TX USA.
RP Wehrum, MJ (reprint author), Yale Univ, Div Maternal Fetal Med, Dept Obstet Gynecol & Reprod Sci, Yale Women & Childrens Ctr Blood Disorders, 333 Cedar St,FMB 339B, New Haven, CT 06520 USA.
EM Mark.Wehrum@Yale.Edu
NR 15
TC 9
Z9 10
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0957-5235
J9 BLOOD COAGUL FIBRIN
JI Blood Coagul. Fibrinolysis
PD MAR
PY 2010
VL 21
IS 2
BP 140
EP 143
DI 10.1097/MBC.0b013e3283358179
PG 4
WC Hematology
SC Hematology
GA 555LZ
UT WOS:000274513600007
PM 20083998
ER
PT J
AU Brunye, TT
Mahoney, CR
Lieberman, HR
Taylor, HA
AF Brunye, Tad T.
Mahoney, Caroline R.
Lieberman, Harris R.
Taylor, Holly A.
TI Caffeine modulates attention network function
SO BRAIN AND COGNITION
LA English
DT Article
DE Caffeine; Arousal; Attention networks; Visuospatial attention
ID ANTERIOR CINGULATE CORTEX; WORKING-MEMORY; PREFRONTAL CORTEX;
PSYCHOMOTOR PERFORMANCE; SELECTIVE ATTENTION; COGNITIVE PERFORMANCE;
INHIBITORY CONTROL; CEREBRAL-CORTEX; DOPAMINE; MOOD
AB The present work investigated the effects of caffeine (0 mg. 100 mg, 200 mg, 400 mg) on a flanker task designed to test Posner's three visual attention network functions: alerting, orienting, and executive control [Posner, M. I. (2004). Cognitive neuroscience of attention. New York, NY: Guilford Press]. In a placebo-controlled, double-blind study using a repeated-measures design, we found that the effects of caffeine on visual attention vary as a function of dose and the attention network under examination. Caffeine improved alerting and executive control function in a dose-response manner, asymptoting at 200 mg; this effect is congruent with caffeine's adenosine-mediated effects on dopamine-rich areas of brain, and the involvement of these areas in alerting and the executive control of visual attention. Higher doses of caffeine also led to a marginally less efficient allocation of visual attention towards cued regions during task performance (i.e., orienting). Taken together, results of this study demonstrate that caffeine has differential effects on visual attention networks as a function of dose, and such effects have implications for hypothesized interactions of caffeine, adenosine and dopamine in brain areas mediating visual attention. Published by Elsevier Inc.
C1 [Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA.
[Brunye, Tad T.; Mahoney, Caroline R.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA.
[Lieberman, Harris R.] USA, Environm Med Res Inst, Washington, DC USA.
RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA.
EM tbruny01@tufts.edu
NR 94
TC 39
Z9 45
U1 2
U2 26
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0278-2626
J9 BRAIN COGNITION
JI Brain Cogn.
PD MAR
PY 2010
VL 72
IS 2
BP 181
EP 188
DI 10.1016/j.bandc.2009.07.013
PG 8
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 555LP
UT WOS:000274512600004
PM 19733954
ER
PT J
AU Popentiu, AI
Weber-Lauer, C
Nieman, C
Kauvar, DS
Sabau, D
AF Popentiu, A. I.
Weber-Lauer, C.
Nieman, C.
Kauvar, D. S.
Sabau, D.
TI Late presentation of a shrapnel wound-induced traumatic intra-thoracic
abdominal evisceration, as colon perforation with left faecopneumothorax
SO CHIRURGIA
LA English
DT Article
DE intra-thoracic evisceration; complication; faeco-pneumothorax
ID DIAPHRAGMATIC RUPTURE
AB The diaphragmatic hernia is a well recognized and common complication of both the penetrating and blunt thoraco-abdominal trauma. The clinical presentation is eather in the acute phase, or later, when it features the symptoms of obstructive complications. The aim of the study is to report a case of delayed presentation of a blast wound with diaphragmatic hernia, complicated by herniation and perforation of the left colonic angle in the pleural cavity. The report highlights the multiple complications following the initial event and the staged management of the case.
C1 [Popentiu, A. I.] Emergency Mil Hosp Sibiu, Dept Surg, Sibiu, Romania.
[Popentiu, A. I.; Weber-Lauer, C.; Nieman, C.; Kauvar, D. S.] 115th Combat Support Hosp Baghdad, Baghdad, Iraq.
[Weber-Lauer, C.] Bayne Jones Army Community Hosp, Dept Surg, Ft Polk, LA USA.
[Nieman, C.] Womack Army Med Ctr, Dept Radiol, Ft Bragg, NC USA.
[Kauvar, D. S.] Univ Utah, Sch Med, Salt Lake City, UT 84112 USA.
[Kauvar, D. S.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
[Sabau, D.] Victor Papilian Fac Med, Dept Surg Prof, Sibiu, Romania.
RP Popentiu, AI (reprint author), Emergency Mil Hosp, Dept Surg, B Dul Victoriei 44-46 Sibiu, Sibiu, Romania.
EM adipopentiu@yahoo.com
RI Florin, Popentiu/E-5787-2010
NR 10
TC 0
Z9 0
U1 0
U2 0
PU EDITURA CELSIUS
PI BUCHAREST
PA STR LITOVOI VOIEVOD NR 1, BL OD7A, SC A, AP 20, SECTOR 2, BUCHAREST,
00000, ROMANIA
SN 1221-9118
J9 CHIRURGIA-BUCHAREST
JI Chirurgia
PD MAR-APR
PY 2010
VL 105
IS 2
BP 253
EP 256
PG 4
WC Surgery
SC Surgery
GA 593OG
UT WOS:000277467300019
PM 20540242
ER
PT J
AU Rice, KR
Chen, YM
Ali, A
Whitman, EJ
Blase, A
Ibrahim, M
Elsamanoudi, S
Brassell, S
Furusato, B
Stingle, N
Sesterhenn, IA
Petrovics, G
Miick, S
Rittenhouse, H
Groskopf, J
McLeod, DG
Srivastava, S
AF Rice, Kevin R.
Chen, Yongmei
Ali, Amina
Whitman, Eric J.
Blase, Amy
Ibrahim, Mona
Elsamanoudi, Sally
Brassell, Stephen
Furusato, Bungo
Stingle, Norbert
Sesterhenn, Isabell A.
Petrovics, Gyorgy
Miick, Siobhan
Rittenhouse, Harry
Groskopf, Jack
McLeod, David G.
Srivastava, Shiv
TI Evaluation of the ETS-Related Gene mRNA in Urine for the Detection of
Prostate Cancer
SO CLINICAL CANCER RESEARCH
LA English
DT Article
ID TMPRSS2-ERG FUSION TRANSCRIPTS; PCA3; MEN; DIAGNOSIS; BIOPSY; ASSAY
AB Purpose: Prevalent gene fusions in prostate cancer involve androgen-regulated promoters (primarily TMPRSS2) and ETS transcription factors (predominantly ETS-regulated gene (ERG)], which result in tumor selective overexpression of ERG in two thirds of patients. Because diverse genomic fusion events lead to ERG overexpression in prostate cancer, we reasoned that it may be more practical to capture such alterations using an assay targeting ERG sequences retained in such gene fusions. This study evaluates the potential of an assay quantitating ERG mRNA in post-digital rectal exam (DRE) urine for improving prostate cancer detection.
Experimental Design: Patients scheduled to undergo transrectal ultrasound-guided needle biopsy of the prostate were prospectively enrolled. On the day of biopsy, patients provided a urine sample immediately following a DRE. Urine ERG mRNA was measured and normalized to urine prostate-specific antigen (PSA) mRNA using the DTS 400 system. Demographic traits, clinical characteristics and biopsy results were analyzed for association with urine ERG score.
Results: The study was conducted on 237 patients. Prostate cancer was shown on biopsy in 40.9% of study subjects. A higher urine ERG score associated significantly with malignancy on biopsy (P = 0.0145), but not with clinical stage or Gleason score. Urine ERG score performed best in Caucasians and in men with a PSA of <= 4 ng/mL (area under the curve = 0.8).
Conclusions: A higher urine ERG score in post-DRE urine is associated with the diagnosis of prostate cancer on biopsy. Urine ERG score performed particularly well in men with a PSA of <= 4.0 ng/mL, a segment of the screening population in which further diagnostic markers are needed to determine in whom biopsy should be done. Clin Cancer Res; 16(5); 1572-6. (C)2010 AACR.
C1 [Chen, Yongmei; Brassell, Stephen; Stingle, Norbert; Petrovics, Gyorgy; McLeod, David G.; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD USA.
[Rice, Kevin R.; Ali, Amina; Whitman, Eric J.; Ibrahim, Mona; Elsamanoudi, Sally; Brassell, Stephen; McLeod, David G.] Walter Reed Army Med Ctr, Serv Urol, Washington, DC 20307 USA.
[Furusato, Bungo; Sesterhenn, Isabell A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA.
[Blase, Amy; Miick, Siobhan; Rittenhouse, Harry; Groskopf, Jack] Gen Probe Inc, San Diego, CA USA.
RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA.
EM David.McLeod@amedd.army.mil; ssrivastava@cpdr.org
OI Furusato, Bungo/0000-0003-4614-9882
NR 18
TC 32
Z9 35
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1078-0432
J9 CLIN CANCER RES
JI Clin. Cancer Res.
PD MAR 1
PY 2010
VL 16
IS 5
BP 1572
EP 1576
DI 10.1158/1078-0432.CCR-09-2191
PG 5
WC Oncology
SC Oncology
GA 607ZJ
UT WOS:000278545500024
PM 20160063
ER
PT J
AU Lehman, RA
Lenke, LG
Helgeson, MD
Eckel, TT
Keeler, KA
AF Lehman, Ronald A., Jr.
Lenke, Lawrence G.
Helgeson, Melvin D.
Eckel, Tobin T.
Keeler, Kathryn A.
TI Do Intraoperative Radiographs in Scoliosis Surgery Reflect Radiographic
Result?
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID ADOLESCENT IDIOPATHIC SCOLIOSIS; PEDICLE SCREW PLACEMENT; POSTERIOR
SPINAL-FUSION; PLAIN RADIOGRAPHS; COMPUTED-TOMOGRAPHY; VERTEBRAL
ROTATION; ACCURACY; FIXATION; INSTRUMENTATION; DEFORMITIES
AB It is often difficult to predict postoperative radiographic curve magnitude and balance parameters while performing intraoperative correction during scoliosis surgery. We asked whether there was a radiographic correlation between intraoperative long-cassette scoliosis film and postoperative standing radiographs of adolescent idiopathic scoliosis with pedicle screw instrumentation. We retrospectively reviewed 44 patients with adolescent idiopathic scoliosis who underwent posterior instrumentation with pedicle screws. We made preoperative, intraoperative (after instrumentation and correction), and standing postoperative radiographic measurements (eg, curve magnitudes, coronal and sagittal balance, disc angles) and compared those for the intra- and postoperative radiographs. The intraoperative long-cassette scoliosis film correlated with the immediate postoperative standing film for all curve correction and balance parameters. The routine use of a long-cassette intraoperative scoliosis film provides the surgeon with a valuable tool to guide intraoperative decision-making and foreshadows the correction and balance obtained on the immediate postoperative film.
Level of Evidence: Level IV, retrospective study. See Guidelines for Authors for a complete description of levels of evidence.
C1 [Lehman, Ronald A., Jr.] Walter Reed Army Med Ctr, Potomac, MD 20854 USA.
[Helgeson, Melvin D.; Eckel, Tobin T.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC 20307 USA.
[Lenke, Lawrence G.; Keeler, Kathryn A.] Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA.
RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, 1528 Blue Meadow Rd, Potomac, MD 20854 USA.
EM armyspine@yahoo.com
FU Medtronic; DePuy; Axial Biotech; Quality Medical Publishing
FX One or more of the authors (LGL) has received funding from Medtronic,
DePuy, Axial Biotech, and Quality Medical Publishing. Each author
certifies that his or her institution has approved the human protocol
for this investigation, that all investigations were conducted in
conformity with ethical principles of research, and that informed
consent for participation in the study was obtained. This work was
performed at the Walter Reed Army Medical Center, Washington, DC, and
Washington University School of Medicine, St Louis, MO.
NR 25
TC 4
Z9 4
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-921X
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD MAR
PY 2010
VL 468
IS 3
BP 679
EP 686
DI 10.1007/s11999-009-0873-z
PG 8
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA 558HM
UT WOS:000274731700006
PM 19421829
ER
PT J
AU Dawood, M
Taylor, E
Rizkalla, S
AF Dawood, M.
Taylor, E.
Rizkalla, S.
TI Two-way bending behavior of 3-D GFRP sandwich panels with
through-thickness fiber insertions
SO COMPOSITE STRUCTURES
LA English
DT Article
DE Sandwich construction; Membrane action; Plate bending; Non-linear
analysis; Rational approach; Parametric study
AB This paper presents the details of a research program that was conducted to evaluate the two-way bending behavior of 3-D glass fiber reinforced polymer (GFRP) sandwich panels. The panels consist of GFRP skins with a foam core and through-thickness fiber insertions. While the behavior of these panels under one-way bending is relatively well understood the behavior under two-way bending has not yet been investigated. An experimental program was conducted to evaluate the effect of the fiber insertion pattern and the panel thickness on the two-way bending behavior under the effect of a concentrated load. The experimental results were used to verify a non-linear, static finite element model which was used to introduce a simplified method to predict the behavior. The measured and predicted responses indicate that at lower deflections the panel behavior is dominated by plate bending action while for higher deflections membrane action dominates. The finite element analysis was extended to study the effect of different parameters which were not tested in the experimental program. The parametric study indicates that increasing the relative flexural or shear rigidities of the panel alters the behavior towards the plate bending mechanism thereby reducing the percentage of load carried by membrane action. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Dawood, M.] Univ Houston, Dept Civil & Environm Engn, Houston, TX 77204 USA.
[Taylor, E.] USA, Corps Engineers, Area Off, Ft Bragg, NC 28310 USA.
[Rizkalla, S.] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
RP Dawood, M (reprint author), Univ Houston, Dept Civil & Environm Engn, N107 Engn Bldg 1,4800 Calhoun Rd, Houston, TX 77204 USA.
EM mmdawood@uh.edu
OI Dawood, Mina/0000-0003-1941-1240
FU Martin Marietta Composites through the National Science Foundation
(NSF); Industry/University Cooperative Research Center (I/UCRC)
[0741676]
FX The authors would like to acknowledge the support of Martin Marietta
Composites through the National Science Foundation (NSF)
Industry/University Cooperative Research Center (I/UCRC) on Repair of
Buildings and Bridges with Composites (RB2C), award number
0741676. The authors would like to thank Mr. Wesley Ballew for his
support throughout the research program. The authors would also like to
thank Dr. Halit Cenan Mertol and Mr. Charles DeVoto for their efforts in
testing the one-way flexural specimens used to characterize the
fundamental properties of the panels.
NR 12
TC 12
Z9 12
U1 1
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0263-8223
J9 COMPOS STRUCT
JI Compos. Struct.
PD MAR
PY 2010
VL 92
IS 4
BP 950
EP 963
DI 10.1016/j.compstruct.2009.09.040
PG 14
WC Materials Science, Composites
SC Materials Science
GA 547BD
UT WOS:000273859000013
ER
PT J
AU Patel, AJ
Sottos, NR
Wetzel, ED
White, SR
AF Patel, Amit J.
Sottos, Nancy R.
Wetzel, Eric D.
White, Scott R.
TI Autonomic healing of low-velocity impact damage in fiber-reinforced
composites
SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
LA English
DT Article
DE Self-healing materials; Polymer-matrix composites (PMCs); Delamination;
Impact behavior
ID TOUGHENED EPOXY COMPOSITE; COMPRESSIVE STRENGTH; FATIGUE CRACKS;
RESIDUAL STRENGTH; WOVEN COMPOSITES; REPAIR; POLYMER; PREDICTION;
RETARDATION; CHALLENGES
AB In this study autonomic self-healing of impact damage in composite materials is shown using a microen-capsulated healing agent. The components for self-healing, urea-formaldehyde microcapsules containing dicyclopentadiene (DCPD) liquid healing agent and paraffin wax microspheres containing 10 wt% Grubbs' catalyst, have been successfully incorporated in a woven S2-glass-reinforced epoxy composite. Low-velocity impact tests reveal that the self-healing composite panels are able to autonomically repair impact damage. Fluorescent labeling of damage combined with image processing shows that total crack length per imaged cross-section is reduced by 51% after self-healing. A testing protocol based on compression after impact reveals significant recovery of residual compressive strength (RCS) in self-healing panels. Self-healing panels show a higher threshold impact energy before RCS reduction, and as impact energy increases. RCS recovery decreases. Qualitative inspection shows that crack separation increases with increasing impact energy, indicating that self-healing performance depends on the ability to adequately fill damage volume. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Patel, Amit J.; Sottos, Nancy R.; White, Scott R.] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA.
[Patel, Amit J.; Sottos, Nancy R.] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA.
[Wetzel, Eric D.] USA, Res Lab, Div Mat, AMSRD ARL WM MA, Aberdeen Proving Ground, MD 21005 USA.
[White, Scott R.] Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA.
RP White, SR (reprint author), Univ Illinois, Beckman Inst Adv Sci & Technol, 405 N Mathews Ave, Urbana, IL 61801 USA.
EM swhite@illinois.edu
FU US Army Research Laboratory (ARL); U.S. Department of Energy
FX Funding for this project is provided by the US Army Research Laboratory
(ARL). The authors would like to thank Seth Ghiorse and Dan Baechle of
ARL for helpful discussions. The authors would also like to thank John
D. Williams and the Materials Testing Instructional Laboratory at the
University of Illinois (UI) for use of the drop-weight impact tester.
Other facilities used at UI include the Advanced Materials Testing and
Engineering Laboratory, the Composites Manufacturing Laboratory, and the
Beckman Institute for Advanced Science and Technology. Electron
microscopy was carried out in the Center for Microanalysis of Materials
at UI, which is supported by the U.S. Department of Energy.
NR 51
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U1 2
U2 32
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-835X
J9 COMPOS PART A-APPL S
JI Compos. Pt. A-Appl. Sci. Manuf.
PD MAR
PY 2010
VL 41
IS 3
BP 360
EP 368
DI 10.1016/j.compositesa.2009.11.002
PG 9
WC Engineering, Manufacturing; Materials Science, Composites
SC Engineering; Materials Science
GA 557YJ
UT WOS:000274706200004
ER
PT J
AU Derby, R
deWeber, K
AF Derby, Richard
deWeber, Kevin
TI The Athlete and High Altitude
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID ACUTE MOUNTAIN-SICKNESS; PULMONARY-EDEMA; ILLNESS; PERFORMANCE;
TREKKERS; ASCENT; LEVEL
AB DERBY, R. and K. DEWEBER. The athlete and high altitude. Curr. Sports Med. Rep., Vol. 9, No. 2, pp. 79-85, 2010. Expanding athlete participation in high-altitude environments highlights the importance for a sports physician to have a good understanding of the high-altitude illness (HAI) syndromes: acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE). All may occur in the setting of acute altitude exposure higher than 2500 m; incidence and severity increases as altitudes or ascent rates increase. Once HAI is recognized, proven therapies should be instituted to alleviate symptoms and avert the possibility of critical illness. Allowing for acclimatization is the best strategy for preventing HAI. Acetazolamide and dexamethasone are additional preventive measures for AMS/HACE; nifedipine, salmeterol, and phosphodiesterase inhibitors are useful in preventing HAPE. Along with the immediate hazards of HAI with altitude exposure, the sport physician also should be familiar with altitude/hypoxic training practices used by athletes to enhance fitness and performance.
C1 [Derby, Richard; deWeber, Kevin] Uniformed Serv Univ Hlth Sci, Tri Serv Mil Primary Care Sports Med Program, Bethesda, MD 20814 USA.
[deWeber, Kevin] USA, Washington, DC USA.
RP Derby, R (reprint author), Uniformed Serv Univ Hlth Sci, Tri Serv Mil Primary Care Sports Med Program, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM rderby@usuhs.mil
NR 36
TC 2
Z9 4
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1537-890X
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD MAR-APR
PY 2010
VL 9
IS 2
BP 79
EP 85
DI 10.1249/JSR.0b013e3181d404ac
PG 7
WC Sport Sciences
SC Sport Sciences
GA 570IY
UT WOS:000275668100005
PM 20220348
ER
PT J
AU Atkins, JM
Taylor, JC
Kane, SF
AF Atkins, Justin M.
Taylor, Jonathan C.
Kane, Shawn F.
TI Acute and Overuse Injuries of the Abdomen and Groin in Athletes
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID TRANSIENT ABDOMINAL-PAIN; REPAIR; HERNIA
AB ATKINS, J.M., J.C. TAYLOR, and S.F. KANE. Acute and overuse injuries of the abdomen and groin in athletes. Curr. Sports Med. Rep., Vol. 9, No. 2, pp. 115-120, 2010. Abdominal and groin injuries are common problems encountered by athletes across a wide variety of sports. They range from benign but annoying, such as exercise-related transient abdominal pain ( ETAP), to the activity-limiting and possibly career-ending condition of athletic hernia. This article covers ETAP, rectus abdominus injuries, osteitis pubis, athletic hernia, and abdominal/groin hernias to provide an update on the current pathophysiology and treatment of common abdominal and pelvic conditions in the athlete.
C1 [Atkins, Justin M.] Womack Army Med Ctr, Family Med Clin, Ft Bragg, NC 28301 USA.
RP Atkins, JM (reprint author), Womack Army Med Ctr, Family Med Clin, Ft Bragg, NC 28301 USA.
EM justin.atkins@us.army.mil
NR 24
TC 5
Z9 5
U1 2
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1537-890X
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD MAR-APR
PY 2010
VL 9
IS 2
BP 115
EP 120
DI 10.1249/JSR.0b013e3181d40080
PG 6
WC Sport Sciences
SC Sport Sciences
GA 570IY
UT WOS:000275668100012
PM 20220355
ER
PT J
AU Zaleski, L
Turiansky, GW
AF Zaleski, Lisa
Turiansky, George W.
TI Squamous Cell Carcinoma of the Anal Canal
SO CUTIS
LA English
DT Review
ID HUMAN-PAPILLOMAVIRUS INFECTION; CANCER; POPULATION
AB Squamous cell carcinoma of the anal canal (SCCAC) is an increasing concern in the human immunodeficiency virus (HIV)-positive population in the highly active antiretroviral therapy (HAART) era. A discussion of the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of SCCAC is presented, Cutis. 2010;85:143-145.
C1 [Zaleski, Lisa] Expeditionary Hlth Serv Atlantic Fleet, Norfolk, VA USA.
[Turiansky, George W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Turiansky, George W.] Natl Capital Consortium Dermatol Residency Progra, Bethesda, MD USA.
[Turiansky, George W.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA.
[Turiansky, George W.] Natl Naval Med Ctr, Dept Dermatol, Bethesda, MD USA.
RP Zaleski, L (reprint author), Dept Dermatol, 34800 Bob Wilson Dr, San Diego, CA 92134 USA.
NR 12
TC 1
Z9 1
U1 0
U2 0
PU QUADRANT HEALTHCOM INC
PI PARSIPPANY
PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA
SN 0011-4162
J9 CUTIS
JI Cutis
PD MAR
PY 2010
VL 85
IS 3
BP 143
EP 145
PG 3
WC Dermatology
SC Dermatology
GA 573GJ
UT WOS:000275896300008
PM 20408513
ER
PT J
AU Kinnaird, KEH
Sauerwein, TJ
AF Kinnaird, Kate E. H.
Sauerwein, Tom J.
TI LACK OF CORRELATION BETWEEN 1,5-ANHYDROGLUCITOL ASSAY AND ORAL GLUCOSE
TOLERANCE TEST IN PATIENTS WITH CYSTIC FIBROSIS
SO ENDOCRINE PRACTICE
LA English
DT Article
ID DIABETES-MELLITUS; PULMONARY-FUNCTION; MONITORING-SYSTEM; GLYCEMIA;
LEVEL
AB Objective: To determine whether the 1,5-anhydroglucitol (1,5-AG) assay, which reflects serum glucose levels during the preceding 2 weeks, could be used as an alternative to the current standard screening test for cystic fibrosis-related diabetes (CFRD)the oral glucose tolerance test (OGTT).
Methods: Serum 1,5-AG, hemoglobin A1c (A1C), fructosamine, and glucose at various time intervals during the OGTT were measured in 10 patients, 19 to 36 years old, with cystic fibrosis. Correlation coefficients were calculated to compare 1,5-AG with A1C, fructosamine, and serum glucose levels during the OGTT, and the mean 1,5-AG, A1C, and fructosamine for normal glucose tolerance, impaired glucose tolerance (IGT), and CFRD were compared statistically.
Results: On the basis of the 120-minute OGTT, 1 of the 10 study subjects had CFRD and 4 had IGT. The mean 1,5-AG for patients with normal glucose tolerance was not significantly different from that for patients with IGT (P = .063). The 1,5-AG value was not significantly correlated with serum glucose during the OGTT, A1C, or fructosamine.
Conclusion: In this pilot study, we found no significant correlation between 1,5-AG and glucose values during the OGTT or between 1,5-AG and other glycemic markers. Hence, the utility of the 1,5-AG assay for screening for CFRD in the population of patients with cystic fibrosis may be limited. (Endocr Pract. 2010;16:167-170)
C1 [Kinnaird, Kate E. H.] Walter Reed Army Med Ctr, Dept Endocrinol, Washington, DC 20307 USA.
[Sauerwein, Tom J.] San Antonio Mil Med Ctr, Dept Endocrinol, Lackland AFB, TX USA.
RP Kinnaird, KEH (reprint author), Walter Reed Army Med Ctr, Dept Endocrinol, 6900 Georgia Ave, Washington, DC 20307 USA.
EM Kate.Kinnaird@us.army.mil
FU Surgeon General's Office of the Department of the Air Force
FX This study was funded by the Surgeon General's Office of the Department
of the Air Force. We are grateful to Dr. Catherin Selloff and Dr.
Stephen Derdak of the Wilford Hall Medical Center pulmonary clinic for
their help in recruiting patients for this study. In addition, we thank
Dr. Anneke Bush and Dr. Stephanie Fonda for their assistance with
statistical analysis. Elliott Liezl and Terri Magram, our 2 metabolic
nurses, were extremely helpful in collecting blood specimens and
administering the OGTT.
NR 27
TC 1
Z9 1
U1 0
U2 1
PU AMER ASSOC CLIN ENDOCRINOL
PI JACKSONVILLE
PA 1000 RIVERSIDE AVE, STE 205, JACKSONVILLE, FL 32204 USA
SN 1530-891X
J9 ENDOCR PRACT
JI Endocr. Pract.
PD MAR-APR
PY 2010
VL 16
IS 2
BP 167
EP 170
DI 10.4158/EP09149.OR
PG 4
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 593XU
UT WOS:000277497400006
PM 19833588
ER
PT J
AU Matheny, RW
Nindl, BC
Adamo, ML
AF Matheny, Ronald W., Jr.
Nindl, Bradley C.
Adamo, Martin L.
TI Minireview: Mechano-Growth Factor: A Putative Product of IGF-I Gene
Expression Involved in Tissue Repair and Regeneration
SO ENDOCRINOLOGY
LA English
DT Review
ID SKELETAL-MUSCLE HYPERTROPHY; STEM-CELL ACTIVATION;
MESSENGER-RIBONUCLEIC-ACID; SATELLITE CELLS; SPLICE VARIANTS; PROPROTEIN
CONVERTASES; MONOCLONAL-ANTIBODIES; PROGENITOR CELLS; FACTOR (IGF)-I;
NITRIC-OXIDE
AB The discovery that IGF-I mRNAs encoding isoforms of the pro-IGF-I molecule are differentially regulated in response to mechanical stress in skeletal muscle has been the impetus for a number of studies designed to demonstrate that alternative splicing of IGF-I pre-mRNA involving exons 4, 5, and 6 gives rise to a unique peptide derived from pro-IGF-I that plays a novel role in myoblast proliferation. Research suggests that after injury to skeletal muscle, the IGF-IEb mRNA splice variant is up-regulated initially, followed by up-regulation of the IGF-IEa splice variant at later time points. Up-regulation of IGF-IEb mRNA correlates with markers of satellite cell and myoblast proliferation, whereas up-regulation of IGF-IE amRNA is correlated with differentiation to mature myofibers. Due to the apparent role of IGF-IEb up-regulation in muscle remodeling, IGF-IEb mRNA was also named mechano-growth factor (MGF). A synthetically manufactured peptide (also termed MGF) corresponding to the 24 most C-terminal residues of IGF-IEb has been shown to promote cellular proliferation and survival. However, no analogous peptide product of the Igf1 gene has been identified in or isolated from cultured cells, their conditioned medium, or in vivo animal tissues or biological fluids. This review will discuss the relationship of the Igf1 gene to MGF and will differentiate actions of synthetic MGF from any known product of Igf1. Additionally, the role of MGF in satellite cell activation, aging, neuroprotection, and signaling will be discussed. A survey of outstanding questions relating to MGF will also be provided. (Endocrinology 151: 865-875, 2010)
C1 [Matheny, Ronald W., Jr.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
[Adamo, Martin L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA.
[Adamo, Martin L.] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA.
RP Matheny, RW (reprint author), USA, Environm Med Res Inst, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
EM ronald.matheny@us.army.mil
RI Mat Zain, Mazatulikhma/B-2025-2010
FU National Institute [R01AG026012]
FX This work was supported by National Institute on Aging Grant R01AG026012
to M.L.A. and an appointment to the Postgraduate Research Participation
Program at the U.S. Army Research Institute of Environmental Medicine
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and U.S. Army Medical Research and Materiel Command (R.W.M.).
NR 82
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U1 1
U2 10
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAR
PY 2010
VL 151
IS 3
BP 865
EP 875
DI 10.1210/en.2009-1217
PG 11
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 558AF
UT WOS:000274711600007
PM 20130113
ER
PT J
AU Kwok, RM
Moawad, FJ
Laczek, JT
Horwhat, JD
AF Kwok, R. M.
Moawad, F. J.
Laczek, J. T.
Horwhat, J. D.
TI Intestinal endometriosis: an uncommon cause of rectal bleeding
SO ENDOSCOPY
LA English
DT Editorial Material
C1 [Kwok, R. M.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA.
RP Kwok, RM (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, 6900 Georgia Ave, Washington, DC 20307 USA.
EM Ryan.Kwok@amedd.army.mil
NR 4
TC 1
Z9 1
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0013-726X
J9 ENDOSCOPY
JI Endoscopy
PD MAR
PY 2010
VL 42
SU 2
BP E112
EP E113
DI 10.1055/s-0029-1243943
PG 2
WC Gastroenterology & Hepatology; Surgery
SC Gastroenterology & Hepatology; Surgery
GA 571MT
UT WOS:000275756600030
PM 20306398
ER
PT J
AU Bluman, EM
Ficke, JR
Covey, DC
AF Bluman, Eric M.
Ficke, James R.
Covey, Dana C.
TI War Wounds of the Foot and Ankle: Causes, Characteristics, and Initial
Management
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Battlefield injuries; Explosive weaponry; Lower extremity injuries;
Negative pressure wound therapy
ID RED-CROSS; TRAUMATIC AMPUTATION; LEAD-INTOXICATION; BLAST INJURIES;
TECHNIQUE TIP; BALLISTICS; CLASSIFICATION; RESUSCITATION; EXPLOSIONS;
TERRORISM
AB There are many challenges inherent in caring for battlefield injuries to the foot and ankle. Optimal treatment for these injuries continues to change overtime. Newer techniques in the management of massive soft tissue and bony wounds will help to restore the best possible function. These include early damage control surgery, modern limb salvage techniques, and SAWD. The current wars in Iraq and Afghanistan will continue to provide a stimulus for advances in the treatment of high-energy, complex musculoskeletal trauma.
C1 [Bluman, Eric M.] Brigham & Womens Hosp, Dept Orthoped, Foot & Ankle Serv, Boston, MA 02115 USA.
[Bluman, Eric M.] Harvard Univ, Sch Med, Boston, MA USA.
[Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
[Covey, Dana C.] USN, Med Ctr, Dept Orthopaed Surg, San Diego, CA 92134 USA.
RP Bluman, EM (reprint author), Brigham Foot & Ankle Ctr Faulkner, 1153 Ctr St,Suite 56, Boston, MA 02130 USA.
EM ebluman@partners.org
NR 51
TC 7
Z9 8
U1 2
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 1
EP 21
DI 10.1016/j.fcl.2009.11.004
PG 21
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200002
PM 20189114
ER
PT J
AU Bluman, EM
Ficke, JR
AF Bluman, Eric M.
Ficke, James R.
TI Traumatic Foot and Ankle Injuries Related to Recent International
Conflicts Preface
SO FOOT AND ANKLE CLINICS
LA English
DT Editorial Material
C1 [Bluman, Eric M.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Foot & Ankle Serv,Dept Orthoped, Boston, MA 02115 USA.
[Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
RP Bluman, EM (reprint author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Foot & Ankle Serv,Dept Orthoped, 75 Francis St, Boston, MA 02115 USA.
EM ebluman@partners.org; james.ficke@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP XIII
EP XIV
DI 10.1016/j.fcl.2009.12.001
PG 2
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200001
PM 20189113
ER
PT J
AU Kragh, JF
AF Kragh, John F., Jr.
TI Use of Tourniquets and Their Effects on Limb Function in the Modern
Combat Environment
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE First aid; Hemorrhage control; Resuscitation; Mass casualties; Disaster
ID OPERATION-IRAQI-FREEDOM; DAMAGE CONTROL RESUSCITATION; ENDURING-FREEDOM;
CASUALTY CARE; PNEUMATIC TOURNIQUET; HEMORRHAGE CONTROL; TRAUMA; DEATH;
INJURY; EXTREMITY
AB Tourniquets are lifesaving in emergency care of bleeding casualties by controlling hemorrhage and preventing shock. Modern tourniquets used in combat after widespread fielding and universal training have been consistently associated with improved survival with minor morbidity.
C1 USA, Inst Surg Res, Dept Damage Control Resuscitat, Ft Sam Houston, TX 78234 USA.
RP Kragh, JF (reprint author), USA, Inst Surg Res, Dept Damage Control Resuscitat, 3400 Rawley E Chambers Ave,Bldg 3611,Room L82-16, Ft Sam Houston, TX 78234 USA.
EM john.kragh@amedd.army.mil
NR 72
TC 18
Z9 19
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 23
EP 40
DI 10.1016/j.fcl.2009.11.001
PG 18
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200003
PM 20189115
ER
PT J
AU Shawen, SB
Keeling, JJ
Branstetter, J
Kirk, KL
Ficke, JR
AF Shawen, Scott B.
Keeling, John J.
Branstetter, Joanna
Kirk, Kevin L.
Ficke, James R.
TI The Mangled Foot and Leg: Salvage Versus Amputation
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Limb salvage; Amputation; Trauma; Foot; Ankle
ID OPEN CALCANEAL FRACTURES; OPERATION ENDURING FREEDOM; OPEN TIBIAL
FRACTURES; LIMB SALVAGE; LOWER-EXTREMITY; IRAQI FREEDOM; SURAL FLAP;
FOLLOW-UP; RECONSTRUCTION; INJURY
AB Treatment of the severely injured lower extremity and mangled foot is fraught with difficulty. Experience has improved the surgeons' ability to salvage limbs, but has not routinely given them the ability to predict which patients will thrive after this choice is made and executed. The authors believe that involving peers and mentors, patient counselors, educating the patients themselves, and comprehensive rehabilitation programs help to prevent patients from losing the desire to improve during the treatment process so that they can eventually return to a productive life.
C1 [Shawen, Scott B.] Walter Reed Army Med Ctr, Orthopaed Foot & Ankle Serv, Washington, DC 20307 USA.
[Shawen, Scott B.; Keeling, John J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Shawen, Scott B.; Keeling, John J.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA.
[Shawen, Scott B.] Natl Capital Consortium, Bethesda, MD USA.
[Keeling, John J.] Natl Naval Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA.
[Keeling, John J.] Natl Naval Med Ctr, Orthopaed Foot & Ankle Serv, Bethesda, MD 20889 USA.
[Keeling, John J.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Washington, DC USA.
[Branstetter, Joanna] Madigan Army Med Ctr, Orthopaed Surg Serv, Tacoma, WA 98431 USA.
[Kirk, Kevin L.] San Antonio Mil Med Ctr, Integrated Orthoped Surg Serv, San Antonio, TX USA.
[Kirk, Kevin L.] Baylor Univ, Sch Grad Studies, Houston, TX 77030 USA.
[Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
RP Shawen, SB (reprint author), Walter Reed Army Med Ctr, Orthopaed Foot & Ankle Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM scott.shawen@us.army.mil
NR 28
TC 21
Z9 22
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 63
EP 75
DI 10.1016/j.fcl.2009.11.005
PG 13
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200005
PM 20189117
ER
PT J
AU Masini, BD
Murray, CK
Wenke, JC
Hsu, JR
AF Masini, Brendan D.
Murray, Clinton K.
Wenke, Joseph C.
Hsu, Joseph R.
TI Prevention and Treatment of Infected Foot and Ankle Wounds Sustained in
the Combat Environment
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Combat; Trauma; Foot and ankle; Infection
ID OPEN TIBIAL FRACTURES; OPERATION ENDURING FREEDOM; PRESSURE PULSATILE
LAVAGE; DAMAGE CONTROL ORTHOPEDICS; DELAYED SURGICAL-TREATMENT; OPEN
CALCANEAL FRACTURES; OPEN EXTREMITY FRACTURES; FEMORAL-SHAFT FRACTURES;
EXTERNAL FIXATION; SOFT-TISSUE
AB Open fractures to the foot and ankle are a challenge to manage, especially in a combat environment with high-energy explosive injuries, high contamination rates, challenging environmental constraints, different capabilities of medical care, and varying evacuation procedures and times. The management of these combat wounds has not substantially changed over the last 50 years, with early surgical debridement and stabilization, antibiotic administration, and delayed primary closures. Although the civilian community has tried to advance the understanding of open-fracture care during peace time, there are still many unanswered questions with regard to the optimal management of these casualties. Most of the recommendations for combat-related infections are not supported by good cohort controlled studies, much less randomized control trials. Further efforts need to be made to answer many fundamental questions and establish best treatment strategies. This manuscript addresses the data and recommendations for management of combat-wounded soldiers through the various levels of current military medical care.
C1 [Wenke, Joseph C.; Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Masini, Brendan D.; Murray, Clinton K.; Hsu, Joseph R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Hsu, JR (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA.
EM Joseph.Hsu@amedd.army.mil
NR 140
TC 2
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U1 1
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 91
EP 112
DI 10.1016/j.fcl.2009.10.002
PG 22
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200007
PM 20189119
ER
PT J
AU Baechler, MF
Groth, AT
Nesti, LJ
Martin, BD
AF Baechler, Martin F.
Groth, Adam T.
Nesti, Leon J.
Martin, Barry D.
TI Soft Tissue Management of War Wounds to the Foot and Ankle
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE War; Foot; Ankle; Flap; Reconstruction; Microsurgery
ID OPERATION IRAQI-FREEDOM; THIGH PERFORATOR FLAP; BREVIS MUSCLE FLAP;
MICROSURGICAL RECONSTRUCTION; EXTERNAL FIXATION; ENDURING FREEDOM; OPEN
FRACTURES; DISTAL LEG; SURAL FLAP; THERAPY
AB Reconstruction of the war-wounded foot and ankle is a challenging process requiring endurance, patience, diligence, and many harrowing decisions for the patient and surgeon. These decisions involve reconciling the difficult balance between expectations and feasibility. The reconstructive process does not end with the successful healing of a flap. Indeed, the surgeon must counsel the patient that flap coverage is but one small component of the reconstruction process. Multiple procedures may be necessary before the patient reaches maximum function. Overtime, the patient and the surgeon may consider revisions of a flap to improve shoe wear and weight-bearing of the reconstructed foot and ankle. Also of high importance is the availability of a skilled orthotist for custom fitting of braces and shoe wear in the post-reconstructive period. Ultimately, the patient is the final judge of the outcome of foot and ankle reconstruction. It is not a rare occurrence that the patient and surgeon agree at some point during reconstructive efforts that an amputation is the best option.
C1 [Baechler, Martin F.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA.
[Baechler, Martin F.; Martin, Barry D.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
[Groth, Adam T.] Tripler Army Med Ctr, Dept Surg, Orthopaed Surg Serv, Honolulu, HI 96859 USA.
[Nesti, Leon J.] McDonald Army Community Hosp, Dept Surg, Orthopaed Surg Serv, Ft Eustis, VA 23604 USA.
[Nesti, Leon J.] NIAMSD, NIH, Bethesda, MD 20892 USA.
[Martin, Barry D.] Walter Reed Army Med Ctr, Dept Surg, Integrated Plast Surg Serv, Washington, DC 20307 USA.
RP Baechler, MF (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM martin.baechler@us.army.mil
RI Groth, Adam/P-9366-2016
OI Groth, Adam/0000-0003-2475-6200
FU NIAAA NIH HHS [F30 AA005516-01, F30 AA005516-02, F30 AA005516-03]
NR 67
TC 14
Z9 17
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 113
EP 138
DI 10.1016/j.fcl.2009.10.006
PG 26
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200008
PM 20189120
ER
PT J
AU Keeling, JJ
Hsu, JR
Shawen, SB
Andersen, RC
AF Keeling, John J.
Hsu, Joseph R.
Shawen, Scott B.
Andersen, Romney C.
TI Strategies for Managing Massive Defects of the Foot in High-Energy
Combat Injuries of the Lower Extremity
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Open fracture; Calcaneus Fracture; Midfoot fracture; Segmental bone
loos; Bone graft
ID BLAIR TIBIOTALAR ARTHRODESIS; RING EXTERNAL FIXATION; TALAR NECK
FRACTURES; BONE-GRAFT; CALCIUM-SULFATE; ANKLE SURGERY; RECONSTRUCTION;
TISSUE; TALUS; METATARSAL
AB Bone loss caused by blast-related trauma or secondary infection in the foot and ankle continues to be a difficult problem. The high functional demands required of active service members, also create several reconstructive challenges. Because many of these injured warriors have expectation to return to duty, the demands of service require advanced techniques to obtain adequate outcomes. Even simple uniform requirements affect the service member's perception of his/her reconstruction. Furthermore, occupational requirements such as marching and running on uneven ground require adequate functional motion and a sufficient calcaneal fat pad to tolerate the effect.
It is not a stretch to state that the "terminal extremity" drives the success of limb salvage surgery in many of these patients. Moreover, continued research and application of new and improved techniques to address these severe injuries are needed to provide a functional and painless distal extremity in comparison to the high-demand amputee with a well-fitting prosthesis.
C1 [Keeling, John J.] Natl Naval Med Ctr, Orthopaed Foot & Ankle Serv, Bethesda, MD 20889 USA.
[Keeling, John J.] Natl Naval Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA.
[Keeling, John J.; Shawen, Scott B.; Andersen, Romney C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Keeling, John J.; Shawen, Scott B.; Andersen, Romney C.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA.
[Keeling, John J.; Andersen, Romney C.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Washington, DC USA.
[Hsu, Joseph R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Shawen, Scott B.] Walter Reed Army Med Ctr, Orthopaed Foot & Ankle Serv, Washington, DC 20307 USA.
[Shawen, Scott B.] Natl Capital Consortium, Bethesda, MD USA.
RP Keeling, JJ (reprint author), Natl Naval Med Ctr, Orthopaed Foot & Ankle Serv, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM john.keeling@med.navy.mil
NR 41
TC 10
Z9 13
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 139
EP 149
DI 10.1016/j.fcl.2009.10.003
PG 11
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200009
PM 20189121
ER
PT J
AU Fergason, J
Keeling, JJ
Bluman, EM
AF Fergason, John
Keeling, John J.
Bluman, Eric M.
TI Recent Advances in Lower Extremity Amputations and Prosthetics for the
Combat Injured Patient
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Blast-related extremity trauma; Lower limb amputation; Heterotopic
ossification; Prosthetics
ID PARTIAL FOOT AMPUTATIONS; TRANS-TIBIAL AMPUTATION; HETEROTOPIC
OSSIFICATION; TRANSTIBIAL AMPUTATION; KNEE DISARTICULATION; INTERFACE
PRESSURES; ANKLE EXOSKELETONS; SYMES AMPUTATION; SKIN PROBLEMS; AMPUTEES
C1 [Fergason, John] Brooke Army Med Ctr, DOR, Ft Sam Houston, TX 78234 USA.
[Keeling, John J.] Natl Naval Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA.
[Keeling, John J.] Natl Naval Med Ctr, Orthopaed Foot & Ankle Serv, Bethesda, MD 20889 USA.
[Keeling, John J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Keeling, John J.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Bethesda, MD 20889 USA.
[Keeling, John J.] Walter Reed Natl Mil Med Ctr, Orthopaed Surg Serv, Washington, DC USA.
[Bluman, Eric M.] Brigham & Womens Hosp, Dept Orthoped, Boston, MA 02115 USA.
[Bluman, Eric M.] Harvard Univ, Sch Med, Boston, MA USA.
RP Fergason, J (reprint author), Brooke Army Med Ctr, DOR, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM john.fergason1@amedd.army.mil
NR 66
TC 16
Z9 17
U1 1
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 151
EP 174
DI 10.1016/j.fcl.2009.10.001
PG 24
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200010
PM 20189122
ER
PT J
AU Owens, JG
AF Owens, Johnny G.
TI Physical Therapy of the Patient with Foot and Ankle Injuries Sustained
in Combat
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Ankle trauma; Combat injuries; Limb salvage; Rehabilitation
ID OPERATION ENDURING FREEDOM; LOWER-EXTREMITY TRAUMA; LOW-BACK-PAIN; IRAQI
FREEDOM; MOBILIZATION; FRACTURE; OUTCOMES; IMMOBILIZATION; RECRUITMENT;
RESISTANCE
AB Foot and ankle injuries sustained in combat pose a challenge to the rehabilitation specialist. Restoring full ROM, strength, and function can be difficult and lasting impairments are common. Current rehabilitative guidelines with this population are limited. Future research in the civilian and military setting is needed to help guide clinical protocols and appropriate outcome measures.
C1 Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
RP Owens, JG (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM johnny.owens@amedd.army.mil
NR 26
TC 14
Z9 14
U1 1
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 175
EP 186
DI 10.1016/j.fcl.2009.10.005
PG 12
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200011
PM 20189123
ER
PT J
AU Granville, R
Menetrez, J
AF Granville, Robert
Menetrez, Jennifer
TI Rehabilitation of the Lower-Extremity War-Injured at the Center for the
Intrepid
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Center for the intrepid; Amputee care; Rehabilitation of the severely
wounded; Armed Forces Amputee Care Program; Lower-extremity war-injured
ID MANAGEMENT; AMPUTEES
AB The Center for the Intrepid (CFI) is a unique facility among the three amputee care centers that comprise the Armed Forces Amputee Care Program. The mission of the CFI is threefold: (1) to provide the best possible patient care to the severely war-wounded, (2) to educate providers in the most advanced methods of rehabilitation for the severely wounded, and (3) to perform research to improve the care of these war-wounded patients. The center's program is based on three critical factors: (1) concentration of similarly injured patients as a cohort, (2) a multidisciplinary approach to patient care, and (3) the concentration of subspecialty skills that ensures the best possible care at an institutional level. The center's active training program benefits professional and ancillary personnel from military community hospitals that may subsequently treat the center's patients as they transition back to duty or retirement. The center's research may ultimately be generalized to amputees of various ages and etiologies, with the goal of returning these patients to productive, fulfilling lives.
C1 [Menetrez, Jennifer] Brooke Army Med Ctr, Ctr Intrepid, ATTN MCHE DOR I, Ft Sam Houston, TX 78234 USA.
[Granville, Robert] Brooke Army Med Ctr, ATTN MCHE DOR O, Ft Sam Houston, TX 78234 USA.
[Menetrez, Jennifer] Brooke Army Med Ctr, Phys Med Serv, Ft Sam Houston, TX 78234 USA.
RP Menetrez, J (reprint author), Brooke Army Med Ctr, Ctr Intrepid, ATTN MCHE DOR I, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM jennifer.menetrez@amedd.army.mil
FU federal government
FX Research is critical to our efforts to identify appropriate
evidenced-based surgical and rehabilitation techniques that improve
patient outcomes. The majority of our patients elect to enroll in any
number of prospective trials currently underway at BAMC and the CFI. The
Department of Orthopaedics and Rehabilitation currently has over 90
active protocols. Some of these are being conducted in concert with the
Institute of Surgical Research (also located on the BAMC campus) or with
external institutions. The CFI has three full-time physical therapists
dedicated to research. Each of them holds a doctorate. The Department of
Orthopaedics and Rehabilitation employs four full-time research nurses
to assist in data collection. Funding is largely derived from the
federal government, although some projects have industry support
meticulously examined for the ethical nature of the relationships.
NR 11
TC 4
Z9 4
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 187
EP 199
DI 10.1016/j.fcl.2009.10.004
PG 13
WC Orthopedics
SC Orthopedics
GA 745TK
UT WOS:000289189200012
PM 20189124
ER
PT J
AU Rush, JK
Kirk, K
Kirby, J
Hsu, J
AF Rush, Jeremy K.
Kirk, Kevin
Kirby, Jess
Hsu, Joseph
TI Lateral Talar Dome Access Utilizing Temporary Invasive Distraction
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE Talus; Osteochondral Lesions; Osteochondral Fractures; Temporary
Invasive Distraction; Temporary External Fixation
ID OSTEOCHONDRAL LESIONS; TRANSCHONDRAL FRACTURES; ANKLE ARTHROSCOPY;
SURGICAL APPROACH; TALUS; TRANSPLANTATION; DISSECANS; DEFECTS;
OSTEOTOMY; JOINT
AB Background: Autogenous osteochondral grafting is an operative option for the treatment of osteochondral lesions of the talus (OLT). Graft implantation often requires an osteotomy to gain perpendicular access to the recipient site. The purpose of this study was to determine the relative contributions of soft tissue releases, osteotomies, and invasive distraction on perpendicular access to the lateral talar dome. We hypothesized that temporary invasive distraction (TID) would provide greater perpendicular access than anterolateral arthrotomy alone and similar access compared to an anterolateral tibial osteotomy. Materials and Methods: Eight fresh frozen cadaveric limb specimens were utilized. An anterolateral arthrotomy was performed and an osteochondral plug was harvested as far posterior as allowed. An additional two Kirschner wires were placed to mark the borders of the area of access. This process was then repeated utilizing: 1) an external fixator for distraction alone, 2) an anterolateral tibial osteotomy alone (with distraction released), and 3) an anterolateral tibial osteotomy (with distraction reapplied). The area accessible as well as the anterior to posterior (AP) access was measured and recorded for each approach. Results: The approach utilizing TID provided greater access than arthrotomy with regard to AP access (p = 0.0007) as well as area (p = 0.003). The approach utilizing TID alone was equivalent to the anterolateral tibial osteotomy with regard to AP access as well as area. TID combined with osteotomy provided greater access than the TID or osteotomy approaches alone with regard to AP access (p = 0.01 and p = 0.02, respectively) and greater access than the external fixator alone with regard to area (p = 0.02). Conclusion: Temporary distraction utilizing external fixation provides greater perpendicular access than anterolateral arthrotomy and access equivalent to anterolateral osteotomy alone. Clinical Relevance: Utilizing TID may obviate the morbidity and possible complications associated with osteotomy and may prove to be a valuable tool in the treatment or osteochondral lesions of the talus.
C1 [Rush, Jeremy K.; Kirk, Kevin] Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA.
[Kirby, Jess] USA, Trauma Training Ctr, Ryder Trauma Training Ctr, Miami, FL USA.
[Hsu, Joseph] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Rush, JK (reprint author), Brooke Army Med Ctr, Dept Orthoped & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM jeremy.rush@amedd.army.mil
NR 30
TC 4
Z9 4
U1 0
U2 0
PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC
PI SEATTLE
PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA
SN 1071-1007
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD MAR
PY 2010
VL 31
IS 3
BP 236
EP 241
DI 10.3113/FAI.2010.0236
PG 6
WC Orthopedics
SC Orthopedics
GA 573GC
UT WOS:000275895500007
PM 20230702
ER
PT J
AU Ellefsen, KJ
Croize, D
Mazzella, AT
McKenna, JR
AF Ellefsen, Karl J.
Croize, Delphine
Mazzella, Aldo T.
McKenna, Jason R.
TI Reply to the discussion on "Frequency-domain Green's functions for radar
waves in heterogeneous 2.5D media" (K. J. Ellefsen, D. Croizeacute, A.
T. Mazzella, and J. R. McKenna, 2009, GEOPHYSICS, 74, no. 3, J13-J22)
SO GEOPHYSICS
LA English
DT Editorial Material
DE electromagnetic waves; finite difference methods; geomagnetism; Green's
function methods; terrestrial electricity; wave equations
C1 [Ellefsen, Karl J.] US Geol Survey, Denver, CO 80225 USA.
[Croize, Delphine] Univ Oslo, Oslo, Norway.
[Mazzella, Aldo T.] US EPA, Las Vegas, NV 89193 USA.
[McKenna, Jason R.] USA, Engn Res & Dev Ctr, Vicksburg, MS USA.
RP Ellefsen, KJ (reprint author), US Geol Survey, Box 25046, Denver, CO 80225 USA.
EM ellefsen@usgs.gov; croize@geo.uio.no; mazzella.aldo@epa.gov;
Jason.R.McKenna@usace.army.mil
NR 2
TC 0
Z9 0
U1 0
U2 0
PU SOC EXPLORATION GEOPHYSICISTS
PI TULSA
PA 8801 S YALE ST, TULSA, OK 74137 USA
SN 0016-8033
J9 GEOPHYSICS
JI Geophysics
PD MAR-APR
PY 2010
VL 75
IS 2
BP X5
EP X5
DI 10.1190/1.3340918
PG 1
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 585YY
UT WOS:000276868100035
ER
PT J
AU Harwell, XS
AF Harwell, Xenia Srebrianski
TI Beyond Vienna: Contemporary Literature from the Austrian Provinces
SO GERMAN QUARTERLY
LA English
DT Book Review
C1 [Harwell, Xenia Srebrianski] US Mil Acad, West Point, NY 10996 USA.
RP Harwell, XS (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC TEACHERS GERMAN
PI CHERRY HILL
PA 112 HADDONTOWNE COURT #104, CHERRY HILL, NJ 08034-3668 USA
SN 0016-8831
J9 GER QUART
JI Ger. Q.
PD SPR
PY 2010
VL 83
IS 2
BP 261
EP 262
PG 2
WC Language & Linguistics; Literature, German, Dutch, Scandinavian
SC Linguistics; Literature
GA 601AX
UT WOS:000278031500019
ER
PT J
AU Weichel, ED
Bower, KS
Colyer, MH
AF Weichel, Eric D.
Bower, Kraig S.
Colyer, Marcus H.
TI Chorioretinectomy for perforating or severe intraocular foreign body
injuries
SO GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
LA English
DT Article
DE Ocular trauma; Open globe injury; Intraocular foreign body; Globe
perforation; Chorioretinectomy
ID PARS-PLANA VITRECTOMY; PENETRATING OCULAR INJURIES; OPERATION IRAQI
FREEDOM; POSTERIOR SEGMENT; EYE INJURIES; PROGNOSTIC-FACTORS; LENS
IMPLANTATION; PROLIFERATIVE VITREORETINOPATHY; ENDURING FREEDOM; VISUAL
OUTCOMES
AB To report the outcomes of chorioretinectomy versus non-chorioretinectomy in combat ocular injuries where a foreign body penetrated the choroid or perforated the globe.
Retrospective, comparative, consecutive interventional case series of 32 perforating or severe intraocular foreign body combat ocular trauma injuries sustained by United States military soldiers and treated at a single institution from March 2003 to March 2009. Final best-corrected visual acuity (BCVA) in 19 non-chorioretinectomy-treated eyes was compared to 13 chorioretinectomy-treated eyes. The chorioretinectomy group was repaired with a 20 gauge three-port pars plana vitrectomy (PPV) by removing the choroid and/or retina at the impact or perforation site of the foreign body following evacuation from a combat zone. The main outcome measures were best-corrected visual acuity and rates of globe survival, retina reattachment and proliferative vitreoretinopathy.
Thirty-two eyes of 31 patients with a mean age of 29 +/- 9 years (range, 19-53 years) were followed for a median of 463 +/- 226 days (range, 59-1022 days). The mean time of injury to the operating room in the chorioretinectomy group was 12.6 +/- 9.8 days, compared to that of the non-chorioretinectomy group of 22.1 +/- 16.4 days (P = 0.05) Final BCVA a parts per thousand yen20/200 occurred in seven of 13 (54%) of the chorioretinectomy group, compared to two of 19 (11%) in the non-chorioretinectomy group (P = 0.04). Globe survival rates were higher in the chorioretinectomy group [11 of 13 (85%) vs 9 of 19 (45%); P = 0.06], as well as the final retinal reattachment rate [8 of 13 (62%) vs 8 of 19 (42%); P = 0.47]. The proliferative vitreoretinopathy rate was eight of 13 (62%) in the chorioretinectomy group, compared to 14 of 19 (74%) in the non-chorioretinectomy group (P = 0.70). Graft failure occurred in five of six eyes (83%) of non-chorioretinectomy cases, requiring temporary keratoprosthesis and penetrating keratoplasty.
Chorioretinectomy is a surgical option that may improve final BCVA and increase globe survival rates when a foreign body penetrates the choroid or perforates the globe.
C1 [Weichel, Eric D.; Bower, Kraig S.; Colyer, Marcus H.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA.
RP Weichel, ED (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, 6900 Georgia Ave, Washington, DC 20307 USA.
EM ericweichel@gmail.com
NR 72
TC 7
Z9 9
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0721-832X
J9 GRAEF ARCH CLIN EXP
JI Graefes Arch. Clin. Exp. Ophthalmol.
PD MAR
PY 2010
VL 248
IS 3
BP 319
EP 330
DI 10.1007/s00417-009-1236-x
PG 12
WC Ophthalmology
SC Ophthalmology
GA 555GP
UT WOS:000274497200005
PM 20155279
ER
PT J
AU Chan, J
Cohen, J
Shin, J
Hamilton, C
Chen, L
Kapp, D
AF Chan, J.
Cohen, J.
Shin, J.
Hamilton, C.
Chen, L.
Kapp, D.
TI Characteristics of SGO plenary presentations that result in subsequent
publication in peer-reviewed journals: What factors are responsible?
SO GYNECOLOGIC ONCOLOGY
LA English
DT Meeting Abstract
C1 [Chan, J.; Cohen, J.; Shin, J.; Chen, L.] UCSF, Ctr Comprehens Canc, San Francisco, CA USA.
[Hamilton, C.] Walter Reed Army Med Ctr, Bethesda, MD USA.
[Kapp, D.] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAR
PY 2010
VL 116
IS 3
SU 1
MA 392
BP S151
EP S151
PG 1
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 594LA
UT WOS:000277538000380
ER
PT J
AU Miller, C
Hamilton, C
Farley, J
Chernofsky, M
Krivak, T
Miller, A
Brady, M
Staney, M
Rose, S
Maxwell, G
AF Miller, C.
Hamilton, C.
Farley, J.
Chernofsky, M.
Krivak, T.
Miller, A.
Brady, M.
Staney, M.
Rose, S.
Maxwell, G.
TI The impact of disease distribution on survival in patients with
advanced-stage epithelial ovarian cancer cytoreduced to microscopic
residual: A Gynecologic Oncology Group study
SO GYNECOLOGIC ONCOLOGY
LA English
DT Meeting Abstract
C1 [Miller, C.; Hamilton, C.; Staney, M.; Rose, S.; Maxwell, G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Farley, J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Chernofsky, M.] Sibley Mem Hosp, Potomac, MD USA.
[Krivak, T.] Univ Pittsburgh, Magee Womens Hosp, Sewickley, PA USA.
[Miller, A.] Gynecol Oncol Grp, Buffalo, NY USA.
[Brady, M.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAR
PY 2010
VL 116
IS 3
SU 1
MA 35
BP S15
EP S16
PG 2
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 594LA
UT WOS:000277538000032
ER
PT J
AU Risinger, J
Chandramouli, G
Maxwell, G
AF Risinger, J.
Chandramouli, G.
Maxwell, G.
TI Identification of epigenetically downregulated microRNAs in endometrial
cancer
SO GYNECOLOGIC ONCOLOGY
LA English
DT Meeting Abstract
C1 [Risinger, J.; Chandramouli, G.] Michigan State Univ, Grand Rapids, MI USA.
[Maxwell, G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAR
PY 2010
VL 116
IS 3
SU 1
MA 195
BP S78
EP S78
PG 1
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 594LA
UT WOS:000277538000189
ER
PT J
AU Doughty, RA
AF Doughty, Robert A.
TI An Improbable War: The Outbreak of World War I and European Political
Culture before 1914
SO HISTORIAN
LA English
DT Book Review
C1 [Doughty, Robert A.] US Mil Acad, West Point, NY 10996 USA.
RP Doughty, RA (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0018-2370
J9 HISTORIAN
JI Historian
PD SPR
PY 2010
VL 72
IS 1
BP 204
EP 205
PG 2
WC History
SC History
GA 564KJ
UT WOS:000275212700047
ER
PT J
AU Boggs, SA
Ho, J
Jow, TR
AF Boggs, Steven A.
Ho, Janet
Jow, T. Richard
TI Overview of Laminar Dielectric Capacitors
SO IEEE ELECTRICAL INSULATION MAGAZINE
LA English
DT Article
DE capacitor; laminar dielectric; film dielectric; paper
ID FAILURE
C1 [Boggs, Steven A.] Univ Connecticut, Elect Insulat Res Ctr, Storrs, CT 06269 USA.
[Ho, Janet; Jow, T. Richard] USA, Res Lab, Adelphi, MD USA.
RP Boggs, SA (reprint author), Univ Connecticut, Elect Insulat Res Ctr, Storrs, CT 06269 USA.
EM janet.ho@arl.army.mil
NR 7
TC 6
Z9 6
U1 0
U2 9
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0883-7554
J9 IEEE ELECTR INSUL M
JI IEEE Electr. Insul. Mag.
PD MAR-APR
PY 2010
VL 26
IS 2
BP 7
EP 13
PG 7
WC Engineering, Electrical & Electronic
SC Engineering
GA 611JK
UT WOS:000278811200003
ER
PT J
AU Jensen, JO
Trew, RJ
Woolard, DL
Gupta, N
Theriault, JM
Hayat, MM
Li, YQ
Gillespie, P
AF Jensen, James O.
Trew, Robert J.
Woolard, Dwight L.
Gupta, Neelam
Theriault, Jean-Marc
Hayat, Majeed M.
Li, Yanqiu
Gillespie, Patti
TI Special Issue on Enhancement Algorithms, Methodologies and Technology
for Spectral Sensing
SO IEEE SENSORS JOURNAL
LA English
DT Editorial Material
C1 [Jensen, James O.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 20783 USA.
[Trew, Robert J.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
[Gupta, Neelam] USA, Res Lab, Sensors & Electron Devices Div, Adelphi, MD 20783 USA.
[Theriault, Jean-Marc] Def Res & Dev Canada, Valcartier, PQ G3J 1X5, Canada.
[Hayat, Majeed M.] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA.
[Li, Yanqiu] Beijing Inst Technol, Beijing 100081, Peoples R China.
[Gillespie, Patti] USA, Res Lab, Electroopt & Photon Div, Adelphi, MD 20783 USA.
RP Jensen, JO (reprint author), Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 20783 USA.
EM jim.jensen@us.army.mil; trew@ncsu.edu; dwight.woolard@us.army.mil;
jean-marc.theriault@drdc-rddc.gc.ca; hatat@ece.unm.edu;
liyang@mial.iee.ac.cn; patti-gillespie@us.army.mil
RI Hayat, Majeed/E-4924-2010
NR 0
TC 0
Z9 0
U1 0
U2 5
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAR
PY 2010
VL 10
IS 3
BP 373
EP 378
DI 10.1109/JSEN.2010.2041385
PG 6
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 561RN
UT WOS:000274996500001
ER
PT J
AU Kwan, C
Snyder, AP
Erickson, RP
Smith, PA
Maswadeh, WM
Ayhan, B
Jensen, JL
Jensen, JO
Tripathi, A
AF Kwan, Chiman
Snyder, A. Peter
Erickson, Richard P.
Smith, Philip A.
Maswadeh, Waleed M.
Ayhan, Bulent
Jensen, Janet L.
Jensen, James O.
Tripathi, Ashish
TI Chemical Agent Detection Using GC-IMS: A Comparative Study
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Gas chromatography (GC); ion mobility spectrometry (IMS); image
processing; receiver operating characteristic (ROC)
ID GAS-CHROMATOGRAPHY
AB Low-cost and portable gas chromatography-ion mobility spectrometry (GC-IMS) has been used to identify chemicals. To accomplish this, two parameters are used. The first parameter relates to the GC retention time (RT), which is the residence time of an analyte as it passes through the column. Different chemicals have different RTs. The second parameter is the drift time of ionized species derived for a specific chemical in the IMS. Due to molecular cross section, mass, and chemical properties, different chemicals produce ionized species with different drift times. Combining these two parameters, GC-IMS has been shown to distinguish between different chemicals.
Chemical detection and identification are not that easy in practice. First, the concentration of chemicals may be very low, and it may be difficult to determine the chromatographic RT and IMS drift time for chemicals under these conditions. Second, the specific ionized species produced in the IMS are concentration dependent and the IMS spectra obtained at different analyte concentrations are not easily predictable. For example, at low concentrations, chemicals seldom form dimers following atmospheric pressure ionization. The possible presence of either monomers or dimers in the IMS drift tube may confuse the chemical classification process. Third, it is important to estimate the concentration of chemicals, as this information will provide toxicity, and the linear dynamic range of typical IMS systems is relatively low
In this study, an image processing approach to enhancing the GC-IMS signal quality is introduced. The key idea in this approach is to treat GC-IMS data as an image and then apply an anomaly detector to detect and enhance abnormal regions in the image. The results of a study that compares a conventional approach to chemical detection and the introduced image enhancement approach are presented. Receiver operating characteristics curves were used to compare the detection performances of the two approaches.
C1 [Kwan, Chiman; Ayhan, Bulent] Signal Proc Inc, Rockville, MD 20850 USA.
[Maswadeh, Waleed M.] USA, Res Dev & Engn Command, Chem & Biol Point Detect Team, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21040 USA.
[Erickson, Richard P.] Naval Submarine Med Res Lab, Submarine Med & Survival Syst Dept, Groton, CT 06349 USA.
[Smith, Philip A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Jensen, Janet L.] USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Standoff Detect Team, Aberdeen Proving Ground, MD 21040 USA.
[Tripathi, Ashish] Sci Applicat Int Corp, Edgewood, MD 21040 USA.
RP Kwan, C (reprint author), Signal Proc Inc, Rockville, MD 20850 USA.
EM chiman.kwan@signalpro.net
FU Army Research Office [W911NF-08-C-0031]
FX Manuscript received August 09, 2008; revised January 14, 2009; accepted
January 21, 2009. Current version published February 24, 2010. This work
was supported in part by the Army Research Office under Contract
W911NF-08-C-0031. The associate editor coordinating the review of this
paper and approving it for publication was Dr. James Jensen.
NR 11
TC 7
Z9 7
U1 0
U2 24
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
EI 1558-1748
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAR
PY 2010
VL 10
IS 3
BP 451
EP 460
DI 10.1109/JSEN.2009.2038128
PG 10
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 561RO
UT WOS:000274996600001
ER
PT J
AU Gupta, N
AF Gupta, Neelam
TI Spectropolarimetric Imaging of Laser-Induced Fluorescence
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Acoustooptic tunable filter (AOTF); fluorescence spectroscopy;
hyperspectral/polarization imager; liquid crystal variable retarder
(LCVR)
ID TUNABLE FILTERS; POLARIZATION; IMAGER
AB A compact wavelength and polarization agile acoustooptic tunable filter (AOTF)-based imager is used to obtain both spectral and polarization signatures from laser-induced fluorescence in a solution for the first time. This imager covers the visible to near-IR region from 400 to 800 nm, with a 10-nm spectral resolution at 600 nm, it uses an electronically tunable TeO(2) AOTF as a bandpass filter, and a nematic liquid crystal variable retarder to change polarization to obtain two orthogonally polarized images at each spectral wavelength. In this experiment, a blocking filter for the laser was not used before the camera. Here we present fluorescence measurement results for a dilute solution of fluorescein in acetone, using a 532-nm laser. Our results showed that for the vertically polarized exciting light, the fluorescence has a spectropolari-metric dependence in agreement with literature. This imager provides a simpler yet powerful tool to facilitate such measurements remotely with ability to extract both spectral and polarization information at each pixel of an extended sample image.
C1 USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Gupta, N (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM neelam.gupta@us.army.mil
RI Gupta, Neelam/B-8702-2013
NR 22
TC 1
Z9 1
U1 3
U2 9
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAR
PY 2010
VL 10
IS 3
BP 503
EP 508
DI 10.1109/JSEN.2009.2038189
PG 6
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 561RQ
UT WOS:000274996800001
ER
PT J
AU Heinz, DC
Davidson, CE
Ben-David, A
AF Heinz, Daniel C.
Davidson, Charles E.
Ben-David, Avishai
TI Temporal-Spectral Detection in Long-Wave IR Hyperspectral Imagery
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Anomaly; detection; hyperremote sensing; hyperspatial; hyperspectral;
hypertemporal; matched; spectral; temporal
AB Ground-based staring hyperspectral chemical detectors allow for repeated measurements through time with near-perfect image registration. The problem with standard spectral-based hyperspectral detection algorithms is that they do not make effective use of this temporal information. In this paper, we develop new temporal-spectral detection algorithms, and show that significant improvements in detection performance for staring geometry are achieved by making use of statistical and signal information obtained from previous samples. These new algorithms have the advantage that they limit detection to regions where both temporally and spectrally significant events have occurred. We present the development of these algorithms and demonstrate the performance of both temporal-spectral and spectral-only detectors for detection of gaseous plumes using data from a passive long-wave IR hyperspectral sensor.
C1 [Heinz, Daniel C.; Davidson, Charles E.] Sci Technol Corp, Edgewood, MD 21040 USA.
[Ben-David, Avishai] USA, Edgewood Chem Biol Ctr, Edgewood, MD 21010 USA.
RP Heinz, DC (reprint author), Sci Technol Corp, Edgewood, MD 21040 USA.
EM daniel.c.heinz@us.army.mil
NR 11
TC 2
Z9 2
U1 0
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAR
PY 2010
VL 10
IS 3
BP 509
EP 517
DI 10.1109/JSEN.2009.2038624
PG 9
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 559BS
UT WOS:000274795400001
ER
PT J
AU Xie, Z
Bykhovski, A
Gelmont, B
Globus, T
Jensen, JO
AF Xie, Zhen
Bykhovski, Alexei
Gelmont, Boris
Globus, Tatiana
Jensen, James O.
TI Computational Modeling of the Molecular Complex Formed by DIPAIN II and
T-2 Toxin
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Biosensing; computational modeling; solid-state detection; trichothecene
mycotoxins
ID TRICHOTHECENE MYCOTOXINS; CHROMATOGRAPHY
AB A fluorescence enhancement in the visible range under UV excitation has been observed in 2-(diphenylacetyl)-l,3indanedione-l-(p-(dimethylamino)benzaldazine) (DIPAIN) II and its derivatives when associating with trichothecene mycotoxins on the solid support. Chromatographic study has shown that it is the molecular complex formed by weak association between DIPAIN II and 12,13-epoxytrichothec-9-ene-3,4,8,15-tetraol 4,15-diacetate 8-(3-methylbutanoate) (T-2) toxin that is directly related to the enhanced fluorescence activity. Previously, a model was proposed by other group to predict a mechanism of the interaction between the molecules in the complex. In this model, five functional groups and regions of DIPAIN II were identified as possible interaction sites with the toxin compounds. More than one area could interact with the compound at the same time. Inspired by these ideas, three mixture conformations of DIPAIN II and T-2 toxin are generated and studied in this paper. The initial geometric structures of two molecules were constructed according to the published papers, and optimization was performed using the Hartree-Fock and the density functional theories followed by calculations of the excited-state energy. The optimization results indicate that there is no chemical bonding between DIPAIN II and T-2 toxin. Nonbonded interactions between T-2 toxin and DIPAIN II could be responsible for the fluorescence enhancement. This conclusion is in agreement with the prediction of the model. The excitation energies are consistent with the experiment results.
C1 [Xie, Zhen; Bykhovski, Alexei; Gelmont, Boris; Globus, Tatiana] Univ Virginia, Charlottesville, VA 22904 USA.
[Jensen, James O.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 20783 USA.
RP Xie, Z (reprint author), Univ Virginia, Charlottesville, VA 22904 USA.
EM gb7k@virginia.edu
NR 11
TC 0
Z9 0
U1 1
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
EI 1558-1748
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAR
PY 2010
VL 10
IS 3
BP 541
EP 546
DI 10.1109/JSEN.2009.2037290
PG 6
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 559BS
UT WOS:000274795400005
ER
PT J
AU Holthoff, EL
Heaps, DA
Pellegrino, PM
AF Holthoff, Ellen L.
Heaps, David A.
Pellegrino, Paul M.
TI Development of a MEMS-Scale Photoacoustic Chemical Sensor Using a
Quantum Cascade Laser
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Microelectromechanical system (MEMS); photoacoustic spectroscopy (PAS);
quantum cascade laser (QCL); sensor
ID TRACE GAS-DETECTION; ACOUSTIC SPECTROSCOPY; MINIATURIZATION;
INTEGRATION; CELL
AB The development of a microelectromechanical systems-scale photoacoustic chemical sensor is described. Specifically, both a pulsed and a modulated continuous wave quantum cascade laser were used to determine detection limits for dimethyl methylphosphonate (DMMP), a standard nerve gas simulant. These sources were continuously tunable from 9.3 to 10 mu m. We report a minimum detection level of 20 parts-per-billion (ppb) and exceptional agreement between the measured photoacoustic vibrational spectrum and the IR spectrum of DMMP. The results support the continued development of a miniaturized photoacoustic sensor.
C1 [Holthoff, Ellen L.; Pellegrino, Paul M.] USA, Res Lab, Adelphi, MD 20783 USA.
[Heaps, David A.] Astra Zeneca Pharmaceut LP, Wilmington, DE 19850 USA.
RP Holthoff, EL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM ellen.holthoff@us.army.mil; david.heaps@astrazeneca.com;
ppel-legr@arl.army.mil
FU U.S. Army Research Laboratory
FX Manuscript received August 29, 2008; revised February 27, 2009; accepted
March 13, 2009. Current version published February 24, 2010. This work
was supported in part by an appointment to the U.S. Army Research
Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge
Associated Universities (OARU) under a contract with the U. S. Army
Research Laboratory. The associate editor coordinating the review of
this paper and approving it for publication was Dr. James Jensen.
NR 32
TC 30
Z9 31
U1 1
U2 14
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAR
PY 2010
VL 10
IS 3
BP 572
EP 577
DI 10.1109/JSEN.2009.2038665
PG 6
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 561RR
UT WOS:000274996900001
ER
PT J
AU Bykhovski, A
Zhao, PJ
Woolard, D
AF Bykhovski, Alexei
Zhao, Peiji
Woolard, Dwight
TI First Principle Study of the Terahertz and Far-Infrared Spectral
Signatures in DNA Bonded to Silicon Nanodots
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Ab initio; DNA; nano; terahertz
ID ATOMIC CHARGES
AB The first principle study of hydrogen-terminated silicon (111) with deoxyguanosine (dG) residues chemically bonded to a silicon surface via Carbon linkers is performed to reveal new insights into the spectral signatures of constrained DNA chains. Silicon surface structure models are generated to accommodate one or two dG residues. In particular, structural models for two dG residues bonded onto silicon nanodots and that formed a single strand of DNA in the lateral direction (along the surface) were developed. First principle simulations with valence electron basis and effective core potentials are conducted. These studies utilized all-atom geometric optimizations to determine the final conformations and normal mode analyses to derive the spectral absorption information. Stable dG conformations on silicon are obtained for varying types of DNA chain length and Nanodot size/shape. These results show that optically active modes lying within the terahertz spectrum typically arise out of joint coupling between the DNA's vibrational behavior and that of the substrate. However, the dominant absorption line below 6 THz is predicted to most strongly represent the DNA dynamics and effects of sodium, but it is only weakly influenced by the Nanodot vibrations. In this study, the phonon-induced light absorption spectra of the DNA chains were analyzed in the context of nanodot influence (e.g., edge effects). These results suggest that DNA strands can be chemically bonded to arbitrary nanosized features on silicon surfaces without perturbing some of the key spectral signatures in the THz regime, and this suggests active THz illumination strategies for DNA identification and characterization.
C1 [Bykhovski, Alexei; Zhao, Peiji; Woolard, Dwight] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
[Woolard, Dwight] USA, Res Off, Div Elect, Res Triangle Pk, NC 27709 USA.
RP Bykhovski, A (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
EM abykhov@ncsu.edu; pzhao@unity.ncsu.edu; dwight.woolard@us.army.mil
FU National Research Council
FX Manuscript received October 16, 2008; revised January 25, 2009; accepted
February 06, 2009. Current version published February 24, 2010. This
work was supported in part by the National Research Council under Senior
Fellowship Program Physics and Modeling of Terahertz Electronic Devices
and Nanostructures. The associate editor coordinating the review of this
paper and approving it for publication was Dr. James Jensen.
NR 13
TC 1
Z9 1
U1 2
U2 11
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAR
PY 2010
VL 10
IS 3
BP 585
EP 598
DI 10.1109/JSEN.2009.2038442
PG 14
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 561RR
UT WOS:000274996900003
ER
PT J
AU Dhawan, A
Du, Y
Yan, F
Gerhold, MD
Misra, V
Vo-Dinh, T
AF Dhawan, Anuj
Du, Yan
Yan, Fei
Gerhold, Michael D.
Misra, Veena
Vo-Dinh, Tuan
TI Methodologies for Developing Surface-Enhanced Raman Scattering (SERS)
Substrates for Detection of Chemical and Biological Molecules
SO IEEE SENSORS JOURNAL
LA English
DT Article
DE Annealing; focused ion beam; nanoislands; nanopillars; nanowires;
surface-enhanced Raman scattering (SERS); surface plasmons
ID PLASMON RESONANCE; NANOPARTICLE ARRAYS; GOLD NANOPARTICLES; SILVER
ELECTRODE; SPECTROSCOPY; SPECTRA; SENSOR; GRATINGS
AB This paper describes methodologies for developing efficient surface-enhanced Raman scattering (SERS) substrates such as annealing thin gold films for developing gold nanoislands, fabrication of nanopillars arrays and roughened films by employing focused ion beam (FIB) milling of gold films, as well as overcoating deep-UV-fabricated silicon nanowires with a layer of gold film. Excitation of surface plasmons in these gold nanostructures leads to substantial enhancement in the Raman scattering signal obtained from molecules lying in the vicinity of the nanostructure surface. In this paper, we perform comparative studies of SERS signals from molecules such as p-mercaptobenzoic acid and cresyl fast violet attached to or adsorbed on various gold SERS substrates. It was observed that gold-coated silicon nanowire substrates and annealed gold island substrates provided considerably higher SERS signals as compared to those from the FIB patterned substrates and planar gold films. The SERS substrates developed by the different processes were employed for detection of biological molecules such as dipicolinic acid, an excellent marker for spores of bacteria such as Anthrax.
C1 [Dhawan, Anuj; Gerhold, Michael D.] USA, Res Off, Durham, NC 27703 USA.
[Du, Yan; Misra, Veena] N Carolina State Univ, Raleigh, NC 27695 USA.
[Yan, Fei] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA.
RP Dhawan, A (reprint author), USA, Res Off, Durham, NC 27703 USA.
EM anuj.dhawan@duke.edu; ydu@ncsu.edu; fei.yan@duke.edu;
mike.gerhold@us.army.mil; vmisra@ncsu.edu; tuan.vodinh@duke.edu
FU U.S. Army Research Office; National Research Council; National
Institutes of Health [R01 EB006201, R01 ES014774]
FX Manuscript received March 26, 2009; accepted May 24, 2009. Current
version published February 24, 2010. This work was supported by the U.S.
Army Research Office, National Research Council, and by the National
Institutes of Health under Grant R01 EB006201 and Grant R01 ES014774.
The associate editor coordinating the review of this paper and approving
it for publication was Dr. Dwight Woolard.
NR 40
TC 15
Z9 15
U1 2
U2 63
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-437X
J9 IEEE SENS J
JI IEEE Sens. J.
PD MAR
PY 2010
VL 10
IS 3
BP 608
EP 616
DI 10.1109/JSEN.2009.2038634
PG 9
WC Engineering, Electrical & Electronic; Instruments & Instrumentation;
Physics, Applied
SC Engineering; Instruments & Instrumentation; Physics
GA 561RR
UT WOS:000274996900006
ER
PT J
AU Cho, JH
Chen, IR
Feng, PG
AF Cho, Jin-Hee
Chen, Ing-Ray
Feng, Phu-Gui
TI Effect of Intrusion Detection on Reliability of Mission-Oriented Mobile
Group Systems in Mobile Ad Hoc Networks
SO IEEE TRANSACTIONS ON RELIABILITY
LA English
DT Article
DE Intrusion detection; intrusion detection system; mean time to security
failure; mission-oriented group communication systems; mobile ad hoc
networks
ID SENSOR NETWORKS; WIRELESS NETWORKS; SECURITY; OPTIMIZATION; LIFETIME;
MODEL
AB For mission-oriented mobile group systems designed to continue mission execution in hostile environments in the presence of security attacks, it is critical to properly deploy intrusion detection techniques to cope with insider attacks to enhance the system reliability. In this paper, we analyze the effect of intrusion detection system (IDS) techniques on the reliability of a mission-oriented group communication system consisting of mobile groups set out for mission execution in mobile ad hoc networks. Unlike the common belief that IDS should be executed as often as possible to cope with insider attacks to prolong the system lifetime, we discover that IDS should be executed at an optimal rate to maximize the mean time to failure of the system. Further, the optimal rate at which IDS is executed depends on the operational conditions, system failure definitions, attacker behaviors, and IDS techniques used. We develop mathematical models based on Stochastic Petri nets to identify the optimal rate for IDS execution to maximize the mean time to failure of the system, when given a set of parameter values characterizing the operational conditions, and attacker behaviors.
C1 [Cho, Jin-Hee] USA, Res Lab, Adelphi, MD 20783 USA.
[Chen, Ing-Ray] Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA.
[Feng, Phu-Gui] Mitre Corp, Bedford, MA 01730 USA.
RP Cho, JH (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM jinhee.cho@arl.army.mil; irchen@vt.edu; pfeng@mitre.org
NR 31
TC 29
Z9 29
U1 0
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9529
EI 1558-1721
J9 IEEE T RELIAB
JI IEEE Trans. Reliab.
PD MAR
PY 2010
VL 59
IS 1
BP 231
EP 241
DI 10.1109/TR.2010.2040534
PG 11
WC Computer Science, Hardware & Architecture; Computer Science, Software
Engineering; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA 608XA
UT WOS:000278618100025
ER
PT J
AU Fan, XC
McNeese, M
Sun, BJ
Hanratty, T
Allender, L
Yen, J
AF Fan, Xiaocong
McNeese, Michael
Sun, Bingjun
Hanratty, Timothy
Allender, Laurel
Yen, John
TI Human-Agent Collaboration for Time-Stressed Multicontext Decision Making
SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART A-SYSTEMS AND
HUMANS
LA English
DT Article
DE Cognitive agents; context switching; human-centered computing;
naturalistic decision making
ID TEAMWORK; UNCERTAINTY; MODEL
AB Multicontext team decision making under time stress is an extremely challenging issue faced by various real-world application domains. In this paper, we employ an experience-based cognitive agent architecture (called R-CAST) to address the informational challenges associated with military command and control (C(2)) decision-making teams, the performance of which can be significantly affected by dynamic context switching and tasking complexities. Using context switching frequency and task complexity as two factors, we conducted an experiment to evaluate whether the use of R-CAST agents as teammates and decision aids can benefit C(2) decision-making teams. Members from a U. S. Army Reserve Officer Training Corps organization were randomly recruited as human participants. They were grouped into ten human-human teams, each composed of two participants, and ten human-agent teams, each composed of one participant and two R-CAST agents, as teammates and decision aids. The statistical inference of experimental results indicates that R-CAST agents can significantly improve the performance of C(2) teams in multi-context decision making under varying time-stressed situations.
C1 [Fan, Xiaocong; McNeese, Michael; Yen, John] Penn State Univ, University Pk, PA 16802 USA.
[Sun, Bingjun] Telenav Inc, Sunnyvale, CA 94086 USA.
[Hanratty, Timothy; Allender, Laurel] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Fan, XC (reprint author), Penn State Univ, University Pk, PA 16802 USA.
EM xfan@psu.edu; mmcneese@ist.psu.edu; sunbingjun@hotmail.com;
hanratty@arl.army.mil; lallende@arl.army.mil; jyen@ist.psu.edu
FU Army Research Laboratory's Advanced Decision Architectures Collaborative
Technology Alliance [FY06]
FX Manuscript received March 23, 2007; revised April 10, 2009. First
published December 4, 2009; current version published February 18, 2010.
This work was supported by the Army Research Laboratory's Advanced
Decision Architectures Collaborative Technology Alliance as an FY06
Research Task. This paper was recommended by Editor W. Pedrycz.
NR 28
TC 11
Z9 11
U1 0
U2 6
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1083-4427
J9 IEEE T SYST MAN CY A
JI IEEE Trans. Syst. Man Cybern. Paart A-Syst. Hum.
PD MAR
PY 2010
VL 40
IS 2
BP 306
EP 320
DI 10.1109/TSMCA.2009.2035302
PG 15
WC Computer Science, Cybernetics; Computer Science, Theory & Methods
SC Computer Science
GA 558IH
UT WOS:000274734300008
ER
PT J
AU Ballato, A
AF Ballato, Arthur
TI MEMS Fluid Viscosity Sensor
SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
LA English
DT Article; Proceedings Paper
CT Joint Meeting of the 23rd European Frequency and Time Forum/IEEE
International Frequency Control Symposium
CY APR 20-24, 2009
CL Besancon, FRANCE
SP Conseil Reg Franche Comte, Ville Besancon, NIST, IEEE, UFFC Soc, Jet Propuls Lab, Symmetricom, OEwaves, Vectron, Conseil Gen Doubs, Communaute Agglomerat Grand Besancon, Univ Franche Comte, Minist Rech & Enseignement Superieur, Soc Francaise Microtech & Chronometrie, Frequency Elect
ID QUARTZ-CRYSTAL MICROBALANCE; 30 DEGREES C; GAS MIXTURES; THERMAL
CONDUCTIVITY; ACOUSTIC-WAVES; LIQUIDS; MASS; RESONATORS; HELIUM; ARGON
AB Quartz shear resonators are employed widely as sensors to measure Newtonian viscosities of liquids. Perturbation of the electrical equivalent circuit parameters of the plate resonator by the fluid loading permits calculation of the mass density-shear viscosity product. Use of doubly rotated resonators does permit additional information to be obtained, but in no case can the viscosity and mass density values be separated. In these measurements, the resonator surface is exposed to a measurand bath whose extent greatly exceeds the penetration depth of the evanescent shear mode excited by the active element. Here we briefly review past techniques and current art, and sketch a proposal involving the interesting situation in which the separation between the resonator and a confining wall is less than the penetration depth of the fluid occupying the intervening region. To highlight the salient features of this novel case, the discussion is limited to the very idealized circumstance of a strictly 1-D problem, unencumbered by the vicissitudes inevitably encountered in practice. An appendix mentions some of these functional impedimenta and indicates how deviations from ideality might be approached in engineering embodiments. When the fluid confinement is of the order of the penetration depth, the resonator perturbation becomes a sensitive function of the separation, and it is found that viscosity and density may be separately and uniquely determined. Moreover, extreme miniaturization is a natural consequence because the penetration depth generally is on the order of micrometers for frequencies around 1 MHz at temperatures and pressures ordinarily encountered with gases and liquids. Micro-electro-mechanical (MEMS) versions of viscometers and associated types of fluid sensors are thereby enabled.
C1 USA, Commun Elect RDEC, Ft Monmouth, NJ USA.
RP Ballato, A (reprint author), USA, Commun Elect RDEC, Ft Monmouth, NJ USA.
EM a.ballato@ieee.org
NR 100
TC 4
Z9 4
U1 2
U2 12
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0885-3010
J9 IEEE T ULTRASON FERR
JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control
PD MAR
PY 2010
VL 57
IS 3
BP 669
EP 676
DI 10.1109/TUFFC.2010.1463
PG 8
WC Acoustics; Engineering, Electrical & Electronic
SC Acoustics; Engineering
GA 565VH
UT WOS:000275322400024
PM 20211786
ER
PT J
AU Masrur, MA
Chen, Z
Murphey, Y
AF Masrur, M. Abul
Chen, Z.
Murphey, Y.
TI Intelligent diagnosis of open and short circuit faults in electric drive
inverters for real-time applications
SO IET POWER ELECTRONICS
LA English
DT Article
ID MODEL-BASED DIAGNOSIS; NEURAL-NETWORKS; MOTOR DRIVE; CLASSIFICATION;
SYSTEM
AB This study presents a machine learning technique for fault diagnostics in induction motor drives. A normal model and an extensive range of faulted models for the inverter motor combination were developed and implemented using a generic commercial simulation tool to generate voltages and current signals at a broad range of operating points selected by a machine learning algorithm. A structured neural network system has been designed, developed and trained to detect and isolate the most common types of faults: single switch open circuit faults, post short-circuits, short circuits and the unknown faults. Extensive simulation experiments were conducted to test the system with added noise, and the results show that the structured neural network system which was trained by using the proposed machine learning approach gives high accuracy in detecting whether a faulty condition has occurred, thus isolating and pin-pointing to the type of faulty conditions occurring in power electronics inverter-based electrical drives. Finally, the authors show that the proposed structured neural network system has the capability of real-time detection of any of the faulty conditions mentioned above within 20 ms or less.
C1 [Masrur, M. Abul] USA, RDECOM TARDEC, Warren, MI 48397 USA.
[Chen, Z.; Murphey, Y.] Univ Michigan, Dearborn, MI 48128 USA.
RP Masrur, MA (reprint author), USA, RDECOM TARDEC, Warren, MI 48397 USA.
EM md.abul.masrur@us.army.mil
FU US Army RDECOM-TARDEC ILIR
FX The research described in this paper was supported through a funding by
the US Army RDECOM-TARDEC ILIR (In-house Lab. Independent Research)
program.
NR 33
TC 24
Z9 26
U1 0
U2 14
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 1755-4535
J9 IET POWER ELECTRON
JI IET Power Electron.
PD MAR
PY 2010
VL 3
IS 2
BP 279
EP 291
DI 10.1049/iet-pel.2008.0362
PG 13
WC Engineering, Electrical & Electronic
SC Engineering
GA 582PH
UT WOS:000276609400011
ER
PT J
AU Brennan, L
Widder, M
van der Schalie, W
AF Brennan, Linda
Widder, Mark
van der Schalie, William
TI Comparison of Fish and Mammalian Cell Line Responses to Multiple
Chemicals Using Electric Cell-Substrate Impedance Sensing (ECIS)
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Brennan, Linda; Widder, Mark; van der Schalie, William] USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD SPR
PY 2010
VL 46
SU S
BP S101
EP S101
PG 1
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 695JX
UT WOS:000285367500224
ER
PT J
AU Finer, J
Bouchard, R
Chen, XF
Rushton, P
AF Finer, John
Bouchard, Robert
Chen Xianfeng
Rushton, Paul
TI Isolation and Validation of Soybean Promoter Families
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Finer, John; Bouchard, Robert] Ohio State Univ, Wooster, OH 44691 USA.
[Chen Xianfeng] USA, Environm Lab, Engn Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA.
[Rushton, Paul] S Dakota State Univ, Brookings, SD 57007 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD SPR
PY 2010
VL 46
SU S
BP S25
EP S25
PG 1
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 695JX
UT WOS:000285367500056
ER
PT J
AU McNutt, P
AF McNutt, Patricky
TI Development and Application of Embryonic Stem Cell-derived Neurons for
Botulinum Neurotoxin Research
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [McNutt, Patricky] USAMRICD, Aberdeen Proving Ground, MD 21010 USA.
[McNutt, Patricky] US Army, ATTN MAJ, Aberdeen Proving Ground, MD 21010 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD SPR
PY 2010
VL 46
SU S
BP S47
EP S47
PG 1
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 695JX
UT WOS:000285367500105
ER
PT J
AU Miller, A
Gross, C
Nealley, E
Clark, O
Waraich, N
Rodgers, K
Smith, W
AF Miller, Adele
Gross, Clark
Nealley, Eric
Clark, Offie
Waraich, Narinder
Rodgers, Kelly
Smith, William
TI Use of H2AX and Micronuclei Formation to Evaluate Genotoxicity in
Cultured Human Skin Cells Following Sulfur Mustard Exposure
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Miller, Adele; Gross, Clark; Nealley, Eric; Clark, Offie; Waraich, Narinder; Rodgers, Kelly; Smith, William] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD SPR
PY 2010
VL 46
SU S
BP S142
EP S142
PG 1
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 695JX
UT WOS:000285367500318
ER
PT J
AU Nealley, E
Nipwoda, T
Gross, C
Clark, O
Miller, A
Smith, W
AF Nealley, Eric
Nipwoda, Theresa
Gross, Clark
Clark, Offie
Miller, Adele
Smith, William
TI Operation of a Cell Culture Core Laboratory to Provide Human Cell and
Tissue Models used in the Study of Chemical Warfare Agents
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Smith, William] USA, Med Res Inst Chem Def, USAMRICD, Aberdeen Proving Ground, MD 21010 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD SPR
PY 2010
VL 46
SU S
BP S74
EP S74
PG 1
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 695JX
UT WOS:000285367500163
ER
PT J
AU Rastogi, V
Wallace, L
Ryan, S
Shah, S
AF Rastogi, Vipin
Wallace, Lalena
Ryan, Shawn
Shah, Saumil
TI Development of a Novel Bioassay for Detection of Functional Ricin
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Rastogi, Vipin; Wallace, Lalena; Ryan, Shawn; Shah, Saumil] USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD SPR
PY 2010
VL 46
SU S
BP S62
EP S62
PG 1
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 695JX
UT WOS:000285367500138
ER
PT J
AU Widder, M
Brennan, L
van der Schalie, W
AF Widder, Mark
Brennan, Linda
van der Schalie, William
TI A Portable Impedance-Based Biosensor and Automated Cell Maintenance
System for Water Toxicity Testing
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Widder, Mark; Brennan, Linda; van der Schalie, William] USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD SPR
PY 2010
VL 46
SU S
BP S84
EP S84
PG 1
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 695JX
UT WOS:000285367500186
ER
PT J
AU Straight, TM
Merrill, G
Perez, L
Livezey, J
Robinson, B
Lodes, M
Suciu, D
Anderson, B
AF Straight, T. M.
Merrill, G.
Perez, L.
Livezey, J.
Robinson, B.
Lodes, M.
Suciu, D.
Anderson, B.
TI A novel electrochemical device to differentiate pandemic (H1N1) 2009
from seasonal influenza
SO INFLUENZA AND OTHER RESPIRATORY VIRUSES
LA English
DT Article
DE CombiMatrix; electrochemical; influenza; pandemic (H1N1) 2009; swine flu
ID A H1N1; SUBTYPE; ASSAYS
AB Background
One of the challenges of the recent pandemic (H1N1) 2009 influenza outbreak was to differentiate the virus from seasonal influenza when confronting clinical cases. The determination of the virus has implications on treatment choice, and obvious epidemiologic significance.
Objectives
We set out to apply a novel electrochemical device to samples derived from clinical cases of pandemic (H1N1) 2009 influenza to examine the ability of the device to differentiate these samples from cases of seasonal influenza.
Patients/Methods
An IRB approved protocol allowed for the use of original nasal wash samples from 24 confirmed human cases pandemic (H1N1) 2009 influenza. Clinical samples from cases of seasonal influenza (Influenza A/H1N1, A/H3N2, and B) were included as controls. Nucleic acids were extracted and samples examined by the ElectraSense (R) Influenza A assay (CombiMatrix, Inc). Samples were also examined by RT-PCR or Luminex assays as a comparator.
Results and Conclusions
The ElectraSense (R) Influenza A assay correctly identified 23 of 24 samples of laboratory-confirmed pandemic (H1N1) 2009 Influenza. The assay correctly identified all samples of influenza A/H1N1 and A/H3N2, and differentiated these from pandemic (H1N1) 2009 Influenza in all cases. The ElectraSense (R) Influenza A assay proved to be a useful assay to quickly and accurately differentiate pandemic (H1N1) 2009 influenza from seasonal influenza.
C1 [Straight, T. M.; Merrill, G.; Perez, L.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[Lodes, M.; Suciu, D.; Anderson, B.] CombiMatrix Corp, Mukilteo, WA USA.
RP Straight, TM (reprint author), Brooke Army Med Ctr, Dept Clin Invest, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM timothy.m.straight@us.army.mil
NR 13
TC 5
Z9 5
U1 1
U2 13
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1750-2640
J9 INFLUENZA OTHER RESP
JI Influenza Other Respir. Viruses
PD MAR
PY 2010
VL 4
IS 2
BP 73
EP 79
DI 10.1111/j.1750-2659.2009.00123.x
PG 7
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA 554BR
UT WOS:000274411000004
PM 20167047
ER
PT J
AU St Leger, A
Nwankpa, C
AF St Leger, Aaron
Nwankpa, Chika
TI OTA-based transmission line model with variable parameters for analog
power flow computation
SO INTERNATIONAL JOURNAL OF CIRCUIT THEORY AND APPLICATIONS
LA English
DT Article
DE analog computation; power flow; power system emulation; transmission
line model
ID INPUT STAGE; SIMULATION; LINEARIZATION
AB Analog computation has some inherent benefits over traditional digital computation methods and fosters a continued interest in research, specifically in power systems, due to its associated strengths. Among these advantages are physically realizable solutions, much faster computation times and more accurate models. To realize an analog computation environment for power system analysis analog models and their circuit realizations are required. This paper focuses on the design, simulation and hardware verification of transmission line models with variable parameters for the purpose of analog power flow computation. Specifically, pi equivalent lumped parameter and distributed parameter transmission line models with parametric variation based on temperature and frequency are presented. Operational transconductance amplifiers (OTAs) are the primary circuit elements in the hardware designs and allow remote reconfigurability and variation of transmission line parameters via transconductance gain. Test results are presented from a hardware prototype, which was developed and tested based on the proposed analog line models. Copyright (C) 2008 John Wiley & Sons, Ltd.
C1 [Nwankpa, Chika] Drexel Univ, Dept Elect & Comp Engn, Ctr Elect Power Engn, Philadelphia, PA 19104 USA.
[St Leger, Aaron] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
RP Nwankpa, C (reprint author), Drexel Univ, Dept Elect & Comp Engn, Ctr Elect Power Engn, Philadelphia, PA 19104 USA.
EM nwankpa@ece.drexel.edu
FU U.S. Department of Energy [CH11170]; National Science Foundation
[ECS-0601647]
FX Contract/grant sponsor: U.S. Department of Energy; contract/grant
number: CH11170; Contract/grant sponsor: National Science Foundation;
contract/grant number: ECS-0601647
NR 35
TC 1
Z9 1
U1 1
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0098-9886
EI 1097-007X
J9 INT J CIRC THEOR APP
JI Int. J. Circuit Theory Appl.
PD MAR
PY 2010
VL 38
IS 2
BP 199
EP 220
DI 10.1002/cta.555
PG 22
WC Engineering, Electrical & Electronic
SC Engineering
GA 570SX
UT WOS:000275699400006
ER
PT J
AU Fadare, O
Bonvicino, A
Martel, M
Renshaw, IL
Azodi, M
Parkash, V
AF Fadare, Oluwole
Bonvicino, Amanda
Martel, Maritza
Renshaw, Idris L.
Azodi, Masoud
Parkash, Vinita
TI Pleomorphic Rhabdomyosarcoma of the Uterine Corpus: A Clinicopathologic
Study of 4 Cases and a Review of the Literature
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
LA English
DT Review
DE Rhabdomyosarcoma; Pleomorphic; Uterus; Myo-D1
ID MALIGNANT RHABDOID TUMOR; ENDOMETRIAL STROMAL SARCOMA; FEMALE
GENITAL-TRACT; PURE EMBRYONAL RHABDOMYOSARCOMA; ALVEOLAR
RHABDOMYOSARCOMA; EPITHELIOID LEIOMYOSARCOMA; POSTMENOPAUSAL PATIENT;
FALLOPIAN-TUBE; UTERUS; ADULTS
AB We report the clinicopathologic features of 4 cases of pure pleomorphic rhabdomyosarcoma of the uterine corpus with an emphasis on their frequent expression of CD10 and CD56, review the relevant literature, and discuss differential diagnostic considerations. The patients ranged from 51 to 79 years (mean 68 y). All were FIGO stage IIIC to IV at initial surgical staging, and 3 were dead from the disease at an average of 8.6 months follow-up. In addition to the expected findings, other notable morphologic features included tumor giant cells (4/4), osteoclast-like giant cells (1/4), patchy myxoid stroma (4/4), and only infrequent cytoplasmic cross striations (1/4). The tumors in all 4 cases were positive for myogenin, myo-D1, smooth muscle actin, desmin, muscle-specific actin (HHF-35), and CD10; 3 (75%) of 4 cases were positive for calponin and CD56; all cases were negative for cytokeratin 7, synaptophysin, epithelial membrane antigen, placental-like alkaline phosphatase, chromogranin, and a pan-keratin. Twenty-three cases have been reported earlier in the English-language literature between 1969 and 2009. In combination with the current 4, the 27 patients had an age range of 35 to 87 years (mean 66.33 y). Only 1 patient was deemed inoperable; most had staging operations. Following their initial evaluations, 16 (59%) were found to have extrauterine extension of disease. At follow-up, 73% (19/27) were dead from the disease and 19.2% had no evidence of recurrence. Ten (53%) of the 19 deaths occurred within 6.5 months of initial evaluation. Stage at presentation did not have any significant impact on outcome: 73% of the 11 patients with uterus-confined disease at presentation were dead from the disease at follow-up, a rate of disease-associated death that was nearly identical to the 75% in the 16 patients with extrauterine disease at presentation. A wide variety of neoadjuvant and adjuvant therapies were administered, which did not appear to significantly impact outcomes. These data indicate that pleomorphic rhabdomyosarcoma of the uterine corpus is a highly aggressive, rapidly progressive tumor with a high case-fatality rate.
C1 [Fadare, Oluwole; Bonvicino, Amanda] Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX USA.
[Bonvicino, Amanda] San Antonio Uniformed Serv Hlth Educ Consortium, Pathol Program, San Antonio, TX USA.
[Bonvicino, Amanda] Brooke Army Med Ctr, Dept Pathol & Lab Serv, Ft Sam Houston, TX 78234 USA.
[Renshaw, Idris L.] Vanguard Pathol Associates, Austin, TX USA.
[Fadare, Oluwole] Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37332 USA.
[Martel, Maritza] Yale New Haven Med Ctr, Dept Pathol, New Haven, CT 06504 USA.
[Martel, Maritza] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA.
[Martel, Maritza; Azodi, Masoud; Parkash, Vinita] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA.
[Parkash, Vinita] Bridgeport Hosp, Dept Pathol, Bridgeport, CT USA.
[Martel, Maritza] Providence Hlth & Serv, Portland, OR USA.
RP Fadare, O (reprint author), Vanderbilt Univ, Med Ctr, Dept Pathol, 1161 21st Ave S,MCN Rm C-2310D, Nashville, TN 37332 USA.
EM oluwolefadare@yahoo.com
NR 82
TC 12
Z9 14
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0277-1691
J9 INT J GYNECOL PATHOL
JI Int. J. Gynecol. Pathol.
PD MAR
PY 2010
VL 29
IS 2
BP 122
EP 134
DI 10.1097/PGP.0b013e3181bc98c0
PG 13
WC Obstetrics & Gynecology; Pathology
SC Obstetrics & Gynecology; Pathology
GA 586KN
UT WOS:000276907200005
PM 20173498
ER
PT J
AU Jarman, R
Myint, KSA
Shrestha, S
Gaywee, J
Velasco, JM
Yoon, IK
Saunders, D
Timmermans, A
Ungchusak, K
Wongstitwilairoong, T
Mason, CJ
Gibbons, RV
Pavlin, JA
AF Jarman, R.
Myint, K. S. A.
Shrestha, S.
Gaywee, J.
Velasco, J. M.
Yoon, I. -K
Saunders, D.
Timmermans, A.
Ungchusak, K.
Wongstitwilairoong, T.
Mason, C. J.
Gibbons, R. V.
Pavlin, J. A.
TI Influenza surveillance contributions from South and Southeast Asia
SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
LA English
DT Meeting Abstract
C1 [Jarman, R.; Myint, K. S. A.; Shrestha, S.; Gaywee, J.; Velasco, J. M.; Yoon, I. -K; Saunders, D.; Timmermans, A.; Wongstitwilairoong, T.; Mason, C. J.; Gibbons, R. V.; Pavlin, J. A.] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Ungchusak, K.] Minist Publ Hlth, Bangkok, Thailand.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1201-9712
J9 INT J INFECT DIS
JI Int. J. Infect. Dis.
PD MAR
PY 2010
VL 14
SU 1
BP E322
EP E323
DI 10.1016/j.ijid.2010.02.2206
PG 2
WC Infectious Diseases
SC Infectious Diseases
GA 578MQ
UT WOS:000276298201293
ER
PT J
AU Magill, A
AF Magill, A.
TI Choice of Drugs for the Prophylaxis of Malaria in the Americas
SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
LA English
DT Meeting Abstract
C1 [Magill, A.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1201-9712
J9 INT J INFECT DIS
JI Int. J. Infect. Dis.
PD MAR
PY 2010
VL 14
SU 1
BP E23
EP E23
DI 10.1016/j.ijid.2010.02.1538
PG 1
WC Infectious Diseases
SC Infectious Diseases
GA 578MQ
UT WOS:000276298200060
ER
PT J
AU Naraghi-Arani, P
Bavari, S
Gardner, S
Jaing, C
Thissen, J
AF Naraghi-Arani, P.
Bavari, S.
Gardner, S.
Jaing, C.
Thissen, J.
TI Identification of novel microRNA biomarkers of viral infection
SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
LA English
DT Meeting Abstract
C1 [Naraghi-Arani, P.; Gardner, S.; Jaing, C.; Thissen, J.] Lawrence Livermore Natl Lab, Livermore, CA USA.
[Bavari, S.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1201-9712
J9 INT J INFECT DIS
JI Int. J. Infect. Dis.
PD MAR
PY 2010
VL 14
SU 1
BP E364
EP E364
DI 10.1016/j.ijid.2010.02.431
PG 1
WC Infectious Diseases
SC Infectious Diseases
GA 578MQ
UT WOS:000276298201391
ER
PT J
AU Gupta, N
Cho, K
AF Gupta, Nikhil
Cho, Kyu
TI Symposium preview: High strain rate behaviors of composites and
heterogeneous materials
SO JOM
LA English
DT Article
C1 [Gupta, Nikhil] NYU, Polytech Inst, Dept Mech & Aerosp Engn, Brooklyn, NY 11201 USA.
[Cho, Kyu] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Gupta, N (reprint author), NYU, Polytech Inst, Dept Mech & Aerosp Engn, Brooklyn, NY 11201 USA.
EM ngupta@poly.edu; kcho@arl.army.mil
RI Gupta, Nikhil/F-8094-2012
NR 7
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1047-4838
J9 JOM-US
JI JOM
PD MAR
PY 2010
VL 62
IS 3
BP 25
EP 26
DI 10.1007/s11837-010-0044-4
PG 2
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Mineralogy; Mining & Mineral Processing
SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy;
Mining & Mineral Processing
GA 571YI
UT WOS:000275792000006
ER
PT J
AU Ramasamy, M
Wilson, JS
Martins, PB
AF Ramasamy, Manikandan
Wilson, Jacob S.
Martins, Preston B.
TI Interaction of Synthetic Jet with Boundary Layer Using Microscopic
Particle Image Velocimetry
SO JOURNAL OF AIRCRAFT
LA English
DT Article
ID CROSS-FLOW; PIV; ROTOR; VALIDATION
AB The aerodynamic interaction between an unsteady, inclined synthetic jet and a crossflow boundary layer was studied as a precursor toward applying active flow control concepts for rotor applications, such as dynamic stall control and fuselage drag reduction. Because the flowfield offered numerous challenges from a measurement perspective, several experiments were carried out using a phase-locked, two-dimensional microscopic particle image velocity technique in a building block approach, by adding one complexity after another. The procedure began with boundary layer measurements made on a simple flat plate using the microscopic particle image velocity technique. Velocity measurements were made deep in the viscous sublayer, as close as 20 mu m from the surface. Following this, the synthetic jet actuator was characterized while operating in quiescent air as well as in crossflow. The results showed that the evolution of the synthetic jet in crossflow was substantially different from its evolution in quiescent air, suggesting that any flow physics or performance prediction (for example, the depth of penetration of the jet into the boundary layer) made based on the quiescent flow conditions may not be applicable in crossflow. All the momentum added to the boundary layer had its source from the synthetic jet actuator, and the penetration of the jet was limited to the viscous sublayer and log layer; the outer layer was unaffected, despite using a jet to freestream velocity ratio of four. Significant effort was also made to validate the microscopic particle image velocity technique and evaluate its capability to accurately resolve such a complex flowfield. To this end, microscopic particle image velocity measurements were compared with hot-wire measurements made on a simple steady jet, as well as an unsteady, periodic synthetic jet. Excellent correlation was found between the two techniques, validating microscopic particle image velocity measurements.
C1 [Ramasamy, Manikandan] Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA.
[Wilson, Jacob S.; Martins, Preston B.] NASA, Langley Res Ctr, Hampton, VA 23681 USA.
[Martins, Preston B.] USA, Aeroflightdynam Directorate, Res Dev & Engn Command, Joint Res Program Off, Washington, DC USA.
[Ramasamy, Manikandan] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA.
RP Ramasamy, M (reprint author), NASA, Ames Res Ctr, Moffett Field, CA 94035 USA.
EM mani.ramasamy@us.army.mil; jacob.s.wilson@us.army.mil;
preston.b.martin@us.army.mil
NR 42
TC 7
Z9 7
U1 0
U2 10
PU AMER INST AERONAUT ASTRONAUT
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0021-8669
J9 J AIRCRAFT
JI J. Aircr.
PD MAR-APR
PY 2010
VL 47
IS 2
BP 404
EP 422
DI 10.2514/1.45794
PG 19
WC Engineering, Aerospace
SC Engineering
GA 581ZT
UT WOS:000276565300005
ER
PT J
AU Waibel, KH
Gomez, R
AF Waibel, Kirk H.
Gomez, Robert
TI Ovalbumin content in 2009 to 2010 seasonal and H1N1 monovalent influenza
vaccines
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Letter
ID EGG ALLERGY; VACCINATION
C1 [Waibel, Kirk H.] Brooke Army Med Ctr, Dept Med, Allergy Immunol Serv, Ft Sam Houston, TX 78234 USA.
[Gomez, Robert] Wilford Hall USAF Med Ctr, Allergy Immunol Clin, Dept Med, Lackland AFB, TX USA.
RP Waibel, KH (reprint author), Brooke Army Med Ctr, Dept Med, Allergy Immunol Serv, Ft Sam Houston, TX 78234 USA.
EM kirk.waibel@amedd.army.mil
NR 9
TC 25
Z9 26
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD MAR
PY 2010
VL 125
IS 3
BP 749
EP 751
DI 10.1016/j.jaci.2009.12.015
PG 3
WC Allergy; Immunology
SC Allergy; Immunology
GA 573BK
UT WOS:000275883200037
PM 20060576
ER
PT J
AU Brodhead, MJ
AF Brodhead, Michael J.
TI Class and Race in the Frontier Army: Military Life in the West,
1870-1890
SO JOURNAL OF AMERICAN HISTORY
LA English
DT Book Review
C1 [Brodhead, Michael J.] US Army Corps Engineers, Off Hist, Alexandria, VA USA.
RP Brodhead, MJ (reprint author), US Army Corps Engineers, Off Hist, Alexandria, VA USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ORGANIZATION AMER HISTORIANS
PI BLOOMINGTON
PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA
SN 0021-8723
J9 J AM HIST
JI J. Am. Hist.
PD MAR
PY 2010
VL 96
IS 4
BP 1189
EP 1190
PG 2
WC History
SC History
GA 579ZO
UT WOS:000276416200066
ER
PT J
AU Ignaccolo, M
Latka, M
Jernajczyk, W
Grigolini, P
West, BJ
AF Ignaccolo, Massimiliano
Latka, Mirek
Jernajczyk, Wojciech
Grigolini, Paolo
West, Bruce J.
TI The dynamics of EEG entropy
SO JOURNAL OF BIOLOGICAL PHYSICS
LA English
DT Article
DE EEG; Entropy; Statistical analysis
ID RANGE TEMPORAL CORRELATIONS; TEEN BIRTH PHENOMENON; MATHEMATICAL-THEORY;
SCALING BEHAVIOR; TIME-SERIES; BRAIN; ELECTROENCEPHALOGRAM;
COMMUNICATION; FLUCTUATIONS; OSCILLATIONS
AB The scaling properties of human EEG have so far been analyzed predominantly in the framework of detrended fluctuation analysis (DFA). In particular, these studies suggested the existence of power-law correlations in EEG. In DFA, EEG time series are tacitly assumed to be made up of fluctuations, whose scaling behavior reflects neurophysiologically important information and polynomial trends. Even though these trends are physiologically irrelevant, they must be eliminated (detrended) to reliably estimate such measures as Hurst exponent or fractal dimension. Here, we employ the diffusion entropy method to study the scaling behavior of EEG. Unlike DFA, this method does not rely on the assumption of trends superposed on EEG fluctuations. We find that the growth of diffusion entropy of EEG increments of awake subjects with closed eyes is arrested only after approximately 0.5 s. We demonstrate that the salient features of diffusion entropy dynamics of EEG, such as the existence of short-term scaling, asymptotic saturation, and alpha wave modulation, may be faithfully reproduced using a dissipative, first-order, stochastic differential equation-an extension of the Langevin equation. The structure of such a model is utterly different from the "noise+trend" paradigm of DFA. Consequently, we argue that the existence of scaling properties for EEG dynamics is an open question that necessitates further studies.
C1 [Ignaccolo, Massimiliano] Duke Univ, Dept Phys, Durham, NC 27706 USA.
[Latka, Mirek] Wroclaw Univ Technol, Inst Biomed Engn, PL-50370 Wroclaw, Poland.
[Jernajczyk, Wojciech] Inst Psychiat & Neurol, Dept Clin Neurophysiol, Warsaw, Poland.
[Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA.
[West, Bruce J.] USA, Math & Informat Sci Directorate, Res Off, Durham, NC USA.
RP Ignaccolo, M (reprint author), Duke Univ, Dept Phys, Durham, NC 27706 USA.
EM mi8@phy.duke.edu
NR 29
TC 12
Z9 12
U1 2
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0092-0606
J9 J BIOL PHYS
JI J. Biol. Phys.
PD MAR
PY 2010
VL 36
IS 2
BP 185
EP 196
DI 10.1007/s10867-009-9171-y
PG 12
WC Biophysics
SC Biophysics
GA 558AI
UT WOS:000274711900006
PM 19669909
ER
PT J
AU Zacchilli, MA
Owens, BD
AF Zacchilli, Michael A.
Owens, Brett D.
TI Epidemiology of Shoulder Dislocations Presenting to Emergency
Departments in the United States
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID INJURIES; CHILDREN
AB Background: The epidemiology of traumatic shoulder dislocations is poorly understood. The aim of the current study was to determine the incidence of shoulder dislocations presenting to hospital emergency departments in the United States and define demographic risk factors for these injuries.
Methods: The National Electronic Injury Surveillance System, a probability sample of all injuries presenting to emergency departments in the United States, was queried for shoulder dislocations from 2002 through 2006. Patient and injury characteristics were analyzed. United States Census data were utilized to calculate incidence rates for the United States population and subgroups. Incidence rate ratios were then calculated with respect to age, sex, and race.
Results: A total of 8940 shoulder dislocations were identified, resulting in an overall incidence rate in the United States of 23.9 (95% confidence interval, 20.8 to 27.0) per 100,000 person-years. The male incidence rate was 34.90 (95% confidence interval, 30.08 to 39.73) per 100,000 person-years, with an incidence rate ratio of 2.64 (95% confidence interval, 2.39 to 2.88) relative to the female incidence rate. It was found that 71.8% of the dislocations were in males. Stratified by decade, the maximum incidence rate (47.8 [95% confidence interval, 41.0 to 54.5]) occurred in those between the ages of twenty and twenty-nine years; 46.8% of all dislocations were in patients between fifteen and twenty-nine years of age. There were no significant differences based on race. Dislocations most frequently resulted from a fall (58.8%) and occurred at home (47.7%) or at sites of sports or recreation (34.5%). Overall, 48.3% of injuries occurred during sports or recreation.
Conclusions: The estimated incidence rate of shoulder dislocations in the United States is 23.9 per 100,000 person-years, which is approximately twice the previously reported value. A young age and male sex are risk factors for shoulder dislocation in the United States population.
C1 [Zacchilli, Michael A.; Owens, Brett D.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA.
RP Zacchilli, MA (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA.
EM b.owens@us.army.mil
NR 18
TC 95
Z9 97
U1 0
U2 10
PU JOURNAL BONE JOINT SURGERY INC
PI NEEDHAM
PA 20 PICKERING ST, NEEDHAM, MA 02192 USA
SN 0021-9355
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD MAR
PY 2010
VL 92A
IS 3
BP 542
EP 549
DI 10.2106/JBJS.I.00450
PG 8
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA 564KT
UT WOS:000275213800003
PM 20194311
ER
PT J
AU Duran-Stanton, AM
Bui-Mansfield, LT
AF Duran-Stanton, Amelia M.
Bui-Mansfield, Liem T.
TI Magnetic Resonance Diagnosis of Tarsal Tunnel Syndrome Due to Flexor
Digitorum Accessorius Longus and Peroneocalcaneus Internus Muscles
SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
LA English
DT Article
DE tarsal tunnel syndrome; anomalous or accessory muscles of the ankle; MR
imaging
ID SKELETAL-MUSCLE; MR
AB Anomalous muscles of the ankle are common. Although they are often asymptomatic, they can sometimes cause tarsal tunnel syndrome. We report a case of tarsal tunnel syndrome due to flexor digitorum accessorius longus and peroneocalcaneus internus muscles diagnosed on magnetic resonance imaging. Recognition of the most common accessory muscles of the ankle on magnetic resonance imaging and tarsal tunnel syndrome are also reviewed.
C1 [Bui-Mansfield, Liem T.] USUHS, Dept Radiol, Bethesda, MD 20814 USA.
[Duran-Stanton, Amelia M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, San Antonio, TX USA.
[Bui-Mansfield, Liem T.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA.
RP Bui-Mansfield, LT (reprint author), USUHS, Dept Radiol, Bethesda, MD 20814 USA.
EM liem.mansfield@gmail.com
NR 16
TC 8
Z9 8
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0363-8715
J9 J COMPUT ASSIST TOMO
JI J. Comput. Assist. Tomogr.
PD MAR-APR
PY 2010
VL 34
IS 2
BP 270
EP 272
DI 10.1097/RCT.0b013e3181ca7ab8
PG 3
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 581BS
UT WOS:000276496600023
PM 20351519
ER
PT J
AU Henning, MJS
Firoz, BF
AF Henning, Maj. J. Scott
Firoz, Bahar F.
TI Combat Dermatology: The Prevalence of Skin Disease in a Deployed
Dermatology Clinic in Iraq
SO JOURNAL OF DRUGS IN DERMATOLOGY
LA English
DT Article
AB Background: Since July 2004, the United States (U.S.) Army has operated a forward-deployed dermatology clinic in Baghdad, Iraq. This paper outlines the prevalence of skin disease among deployed service men and women in Operation Iraqi Freedom.
Methods: A cross-sectional study was performed for all dermatology visits presenting to the Combat Dermatology Clinic, Ibn Sina, Iraq, between January 15, 2008 and July 15, 2008.
Results: In the six-month period reviewed, 2,696 total patients were evaluated. The most prevalent diagnoses included eczematous dermatitis [17%, n=462] and benign neoplasms [14%, n=375]. Eight percent (n=205) of the total visits were for skin cancer. This included: basal cell carcinoma, squamous cell carcinoma both in-situ and invasive, mycosis fungoides and melanoma. Actinic keratosis comprised 5% of the total visits (n=129). Bacterial infections comprised 6% (n=158) of the total visits and 31 of these cases were community acquired methicillin resistant Staphylococcus aureus (MRSA). Limitations: Cross-sectional study with referral bias.
Conclusion: This is the largest publication of the prevalence of skin disease in an exclusively dermatologic clinic in a combat setting. For the first time the presence of skin cancer is noted in a combat setting. The prevalence of MRSA is noted and was exclusively seen in U.S. soldiers. There was a statistically significant rise in the prevalence of eczematous dermatitides when compared with previous conflicts. Dermatologists can have a significant and strategic impact on deployed military medicine.
C1 [Henning, Maj. J. Scott] Brooke Army Med Ctr, Dept Dermatol, Ft Sam Houston, TX 78234 USA.
[Firoz, Bahar F.] Methodist Hosp, Houston, TX 77030 USA.
[Firoz, Bahar F.] Dermatol Surg Associates, Houston, TX USA.
RP Henning, MJS (reprint author), Brooke Army Med Ctr, Dept Dermatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM jeffrey.henning@lackland.af.mil
NR 9
TC 1
Z9 1
U1 0
U2 0
PU JOURNAL OF DRUGS IN DERMATOLOGY
PI NEW YORK
PA 377 PARK AVE SOUTH, 6TH FLOOR, NEW YORK, NY 10016 USA
SN 1545-9616
J9 J DRUGS DERMATOL
JI J. Drugs Dermatol.
PD MAR
PY 2010
VL 9
IS 3
BP 210
EP 214
PG 5
WC Dermatology
SC Dermatology
GA 571IH
UT WOS:000275745000003
ER
PT J
AU Pongruktham, O
Ochs, C
Hoover, JJ
AF Pongruktham, Orathai
Ochs, Clifford
Hoover, Jan Jeffrey
TI Observations of Silver Carp (Hypophthalmichthys molitrix) Planktivory in
a Floodplain Lake of the Lower Mississippi River Basin
SO JOURNAL OF FRESHWATER ECOLOGY
LA English
DT Article
ID RESERVOIR; PASSAGE; BIOMASS; BRAZIL; VAL
AB The invasive silver carp (Hypophthalmichthys molitrix) has become pervasive in much of the Mississippi River, its tributaries, and in connected lakes and wetlands. As an increasingly abundant planktivore, it competes directly for food with native fishes. Its greatest impact may be in connected backwater lakes and wetlands, which due to their high primary production serve as critical sites for feeding and growth of many fishes. To assess the impact that silver carp may have on one such system, we examined the composition of plankton samples and of alimentary tract (gut) contents of carp collected from an oxbow lake in Mississippi, Forest Home Chute. Through an occasional connection to the Mississippi River, Forest Home Chute was invaded by silver carp in winter 2005, after which the river and lake became disconnected for about two years. In the water-column, the most common types of phytoplankton were euglenoid algae, cyanobacteria, and diatoms. The vast majority of zooplankton was rotifers with densities sometimes exceeding 7,000 organisms per liter. Very high concentrations of phytoplankton in the carp gut, relative to in the water-column, indicate substantial consumption of phytoplankton production. In October 2006, euglenoid phytoplankters were a much greater, and cyanobacteria a much lesser, proportion of prey in the fish gut compared to their proportions in the water-column. In December, however, there was no evidence of selective consumption by the silver carp population. Some of the phytoplankters observed in the lowest portion of the gut, including pinnate diatoms and euglenoid algae, were motile, indicating they had survived transit through the 5 to 7-m long gut tract. There was no evidence of rotifer survival of gut passage. By its high consumption of plankton, possible selective planktivory, and differential digestion of consumed phytoplankton and zooplankton, the silver carp may be altering the food web structure of these important connected lakes.
C1 [Pongruktham, Orathai; Ochs, Clifford] Univ Mississippi, Dept Biol, University, MS 38677 USA.
[Hoover, Jan Jeffrey] USA, Engn Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA.
RP Pongruktham, O (reprint author), Univ Mississippi, Dept Biol, University, MS 38677 USA.
FU Department of Biology, University of Mississippi; US Army Corps of
Engineers Aquatic Nuisance Species Research Program
FX Assistance in the field was provided by J. Beard, H. Capello, S. George,
J. Killgore, W. Lancaster, B. Lewis, C. Murphy, and K. Varble. Support
for travel was provided by the Department of Biology, University of
Mississippi and the US Army Corps of Engineers Aquatic Nuisance Species
Research Program. Permission to publish was granted by the Chief of
Engineers.
NR 23
TC 5
Z9 6
U1 4
U2 22
PU OIKOS PUBL INC
PI LA CROSSE
PA PO BOX 2558, LA CROSSE, WI 54601 USA
SN 0270-5060
J9 J FRESHWATER ECOL
JI J. Freshw. Ecol.
PD MAR
PY 2010
VL 25
IS 1
BP 85
EP 93
DI 10.1080/02705060.2010.9664361
PG 9
WC Ecology; Limnology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 565LH
UT WOS:000275293500011
ER
PT J
AU Casper, AF
Johnson, LE
AF Casper, Andrew F.
Johnson, Ladd E.
TI Contrasting shell/tissue characteristics of Dreissena polymorpha and
Dreissena bugensis in relation to environmental heterogeneity in the St.
Lawrence River
SO JOURNAL OF GREAT LAKES RESEARCH
LA English
DT Article
DE Environmental heterogeneity; Physiological plasticity; Competition;
Growth
ID LOWER GREAT-LAKES; ZEBRA MUSSEL; QUAGGA MUSSELS; NORTH-AMERICA; ENERGY
ALLOCATION; ZOOPLANKTON; REPLACEMENT; ESTUARIES; FREQUENCY; SALINITY
AB The zebra mussel, Dreissena polymorpha, is widespread in the St. Lawrence River while the conspecific quagga mussel, Dreissena bugensis, is found only in the Lake Ontario outflow region of the river. This situation provided an opportunity to evaluate in situ environmental and interspecific heterogeneity in shell and tissue growth. Shell dry weight, carbon content, and shell strength of D. polymorpha from the four spatially discrete water masses differed significantly. For instance, D. polymorpha total and tissue mass increased over the summer in the shallow fluvial Lac Saint-Pierre but decreased in the upstream and downstream water masses. Standardized shell mass and strength of a polymorpha was lowest where the mussels experienced salinity or low calcium. Although the response pattern of mass and glycogen content for D. polymorpha was spatially complex, mussels from the stressful oligohaline estuary population had the weakest shells and lowest glycogen content, even though their standardized tissue mass was the heaviest. This disparity in shell and tissue response suggests that some aspect of shell physiology alone may be limiting these mussels in estuarine environments. Tissue characteristics of D. polymorpha and D. bugensis were similar at the site where both were present, but the shell strength of D. bugensis was only equivalent to the weakest of D. polymorpha. We also conclude that lighter shells might make D. bugensis more susceptible to predation or mechanical damage but may also offer a bioenergetic advantage that is contributing to its rapid displacement of D. polymorpha where the two species co-occur. Published by Elsevier B.V.
C1 [Casper, Andrew F.] USA, Corps Engineers, Aquat Ecol & Invas Species Branch, Environm Lab,ERDC,Waterways Expt Stn, Vicksburg, MS 39180 USA.
[Casper, Andrew F.; Johnson, Ladd E.] Univ Laval, Quebec Ocean & Dept Biol, Quebec City, PQ G1K 7P4, Canada.
RP Casper, AF (reprint author), USA, Corps Engineers, Aquat Ecol & Invas Species Branch, Environm Lab,ERDC,Waterways Expt Stn, Vicksburg, MS 39180 USA.
EM andrew.f.casper@usace.army.mil
RI Johnson, Ladd/C-7449-2012
NR 35
TC 8
Z9 8
U1 2
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0380-1330
J9 J GREAT LAKES RES
JI J. Gt. Lakes Res.
PD MAR
PY 2010
VL 36
IS 1
BP 184
EP 189
DI 10.1016/j.jglr.2009.10.001
PG 6
WC Environmental Sciences; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 573BE
UT WOS:000275882600021
ER
PT J
AU Priddy, LP
Newman, JK
AF Priddy, Lucy Phillips
Newman, John Kent
TI Full-Scale Field Testing for Verification of Mechanical Properties of
Polyurethane Foams for Use as Backfill in PCC Repairs
SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING
LA English
DT Article
ID OPEN-CELL FOAMS; COMPRESSIVE RESPONSE; BEHAVIOR
AB Laboratory and field investigations were performed on several commercially available rigid polyurethane foam materials to determine their suitability as base replacement materials for full-depth portland concrete cement (PCC) pavement repairs. Rigid polyurethane foam (RPF) specimens were prepared and tested to evaluate the compressive strength, reactivity, and density of several foam materials under a variety of temperature conditions, where properties were investigated for thermal variations expected in field placement. Following laboratory testing, full-scale field testing of full-depth PCC repairs was conducted using two RPFs of densities of approximately 160 kg/m(3) (10 lb/ft(3)) and 240 kg/m(3) (15 lb/ft(3)) to verify laboratory predicted performance under elevated and ideal field temperatures. Each repair was trafficked within 3 h of repair completion with an F-15E load cart to simulate fighter aircraft traffic on early-age repairs. Results of laboratory and field testing indicate that high-density RPF materials are suitable as base replacement materials for temporary pavement repairs on airfields. For optimum field performance a RPF with minimum density of 240 kg/m(3) (15 lb/ft(3)) should be placed at a temperature of 23 degrees C (70 degrees F).
C1 [Priddy, Lucy Phillips; Newman, John Kent] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Priddy, LP (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM Lucy.P.Priddy@usace.army.mil; John.K.Newman@usace.army.mil
FU Headquarters, Air Combat Command; U.S. Army Engineering Research and
Development Center, Waterways Experiment Station
FX The tests described and the resulting data presented herein, unless
otherwise noted, were obtained from research conducted under the
Airfield Damage Repair (ADR) Civil Engineer Modernization program
currently sponsored by Headquarters, Air Combat Command by the U.S. Army
Engineering Research and Development Center, Waterways Experiment
Station. Permission was granted by the laboratory director to publish
this information. The Headquarters, Department of the Army, sponsored
the research reported herein. The support of the U.S. Army Engineer
Research and Development Center, Waterways Experiment Station, is
gratefully acknowledged. The U.S. Army Engineer Research and Development
Center does not endorse any of the materials reported herein.
NR 17
TC 6
Z9 6
U1 3
U2 7
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0899-1561
J9 J MATER CIVIL ENG
JI J. Mater. Civ. Eng.
PD MAR
PY 2010
VL 22
IS 3
BP 245
EP 252
DI 10.1061/(ASCE)0899-1561(2010)22:3(245)
PG 8
WC Construction & Building Technology; Engineering, Civil; Materials
Science, Multidisciplinary
SC Construction & Building Technology; Engineering; Materials Science
GA 555OQ
UT WOS:000274522200006
ER
PT J
AU Kupp, ER
Messing, GL
Anderson, JM
Gopalan, V
Dumm, JQ
Kraisinger, C
Ter-Gabrielyan, N
Merkle, LD
Dubinskii, M
Simonaitis-Castillo, VK
Quarles, GJ
AF Kupp, Elizabeth R.
Messing, Gary L.
Anderson, Julie M.
Gopalan, Venkatraman
Dumm, John Q.
Kraisinger, Charles
Ter-Gabrielyan, Nikolay
Merkle, Larry D.
Dubinskii, Mark
Simonaitis-Castillo, Vida K.
Quarles, Gregory J.
TI Co-casting and optical characteristics of transparent segmented
composite Er:YAG laser ceramics
SO JOURNAL OF MATERIALS RESEARCH
LA English
DT Article
ID ND-YAG CERAMICS; PERFORMANCE; POLYCRYSTALLINE; FABRICATION; ROD
AB A novel colloidal co-casting process was developed to fabricate laser quality, multisegment composite ceramic laser gain materials. The approach was demonstrated for a three segment transparent composite rod 62 mm long by 3 mm diameter consisting of undoped yttrium aluminus garnet (YAG), 0.25% Er:YAG, and 0.5% Er:YAG. The Er concentration profile in the composite has steep, controllable gradients at the segment interfaces, while maintaining constant dopant concentrations within each segment. The composite rod has 84% transmittance at 1645 nm (the lasing wavelength) with a scatter loss of 0.4% cm(-1). Laser operation of such a composite Er:YAG ceramic rod was demonstrated for the first time, with nearly equivalent lasing behavior to an Er:YAG single crystal rod.
C1 [Kupp, Elizabeth R.; Messing, Gary L.; Anderson, Julie M.; Gopalan, Venkatraman] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Kupp, Elizabeth R.; Messing, Gary L.; Anderson, Julie M.; Gopalan, Venkatraman] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA.
[Dumm, John Q.; Kraisinger, Charles] II VI Inc, AMDC, Saxonburg, PA 16056 USA.
[Ter-Gabrielyan, Nikolay; Merkle, Larry D.; Dubinskii, Mark] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA.
[Simonaitis-Castillo, Vida K.; Quarles, Gregory J.] II VI Inc, VLOC, New Port Richey, FL 34655 USA.
RP Kupp, ER (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
EM kupp@matse.psu.edu
FU High Energy Laser program of the Joint Technology Office
[FA9451-06-D-0012]; National Science Foundation [DMR07-49391]
FX This work was supported by the High Energy Laser program of the Joint
Technology Office under Contract FA9451-06-D-0012 and the National
Science Foundation under Contract DMR07-49391.
NR 22
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Z9 40
U1 2
U2 27
PU MATERIALS RESEARCH SOC
PI WARRENDALE
PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA
SN 0884-2914
J9 J MATER RES
JI J. Mater. Res.
PD MAR
PY 2010
VL 25
IS 3
BP 476
EP 483
DI 10.1557/JMR.2010.0069
PG 8
WC Materials Science, Multidisciplinary
SC Materials Science
GA 564NG
UT WOS:000275221100009
ER
PT J
AU Sood, AK
Puri, YR
Wang, ZL
Polla, DL
Soprano, MB
AF Sood, Ashok K.
Puri, Yash R.
Wang, Zhong L.
Polla, Dennis L.
Soprano, Martin B.
TI Growth of Highly Oriented ZnO Nanowires on GaN Substrates for Electronic
and Optical Sensor Applications
SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
LA English
DT Article
DE ZnO; Nanowires; p-n Junctions; UV Imaging; Highly Oriented ZnO Growth;
Electronic Applications
AB In this Paper we present growth and characterization results of highly oriented ZnO nanowires grown on wide bandgap GaN substrates. Experimental results on the ZnO nanowires grown on p-GaN are presented with growth morphology and dimensionality control. We also present experimental results on these nanowire arrays such as I-V measurements and UV sensitivity measurements. The ZnO nanowires can be used for a variety of nanoscale optical and electronics applications.
C1 [Sood, Ashok K.; Puri, Yash R.] Magnolia Opt Technol Inc, Woburn, MA 01801 USA.
[Wang, Zhong L.] Georgia Inst Technol, Sch Mat Sci, Atlanta, GA 30332 USA.
[Polla, Dennis L.] DARPA MTO, Arlington, VA 22203 USA.
[Soprano, Martin B.] USA, DARPA Programs Off, Redstone Arsenal, AL 35898 USA.
RP Sood, AK (reprint author), Magnolia Opt Technol Inc, 52-B Cummings Pk,Suite 314, Woburn, MA 01801 USA.
RI Wang, Zhong Lin/E-2176-2011
OI Wang, Zhong Lin/0000-0002-5530-0380
FU DARPA; US Army [W31P4QO6-C-0262]
FX This work has been sponsored by DARPA and funded under US Army Contract
Number W31P4QO6-C-0262.
NR 8
TC 9
Z9 9
U1 1
U2 17
PU AMER SCIENTIFIC PUBLISHERS
PI STEVENSON RANCH
PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA
SN 1533-4880
J9 J NANOSCI NANOTECHNO
JI J. Nanosci. Nanotechnol.
PD MAR
PY 2010
VL 10
IS 3
SI SI
BP 1839
EP 1841
DI 10.1166/jnn.2010.2110
PG 3
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA 548RV
UT WOS:000273984800053
PM 20355584
ER
PT J
AU Cardellina, JH
Moore, BS
AF Cardellina, John H., II
Moore, Bradley S.
TI Richard C. Moore (1933-2007)
SO JOURNAL OF NATURAL PRODUCTS
LA English
DT Biographical-Item
ID BLUE-GREEN-ALGAE; LYNGBYA-MAJUSCULA; SCYTONEMA; ALKALOIDS; SCYTOPHYCINS;
PALYTOXIN
C1 [Cardellina, John H., II] USA, Inst Infect Dis, Washington, DC 20310 USA.
[Moore, Bradley S.] Univ Calif San Diego, San Diego, CA 92103 USA.
RP Cardellina, JH (reprint author), USA, Inst Infect Dis, Washington, DC 20310 USA.
NR 18
TC 6
Z9 6
U1 0
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0163-3864
J9 J NAT PROD
JI J. Nat. Prod.
PD MAR
PY 2010
VL 73
IS 3
SI SI
BP 301
EP 302
DI 10.1021/np100045f
PG 2
WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
SC Plant Sciences; Pharmacology & Pharmacy
GA 573CC
UT WOS:000275885000002
PM 20141160
ER
PT J
AU Boyles, RE
Walker, MJ
Young, BA
Strunce, JB
Wainner, RS
AF Boyles, Robert E.
Walker, Michael J.
Young, Brian A.
Strunce, Joseph B.
Wainner, Robert S.
TI The Addition of Cervical Thrust Manipulations to a Manual Physical
Therapy Approach in Patients Treated for Mechanical Neck Pain: A
Secondary Analysis
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE cervical spine; manual therapy; mobilization
ID RANDOMIZED CLINICAL-TRIAL; THORACIC SPINE MANIPULATION; LOW-BACK-PAIN;
GENERAL-PRACTITIONER; DISABILITY INDEX; PREDICTION RULE; CONTINUED CARE;
EXERCISE; MOBILIZATION; HEALTH
AB STUDY DESIGN: Secondary analysis of a randomized clinical trial (RCT).
OBJECTIVES: To perform a secondary analysis on the treatment arm of a larger RCT to determine differences in treatment outcomes, adverse reactions, and effect sizes between patients who received cervical thrust manipulation and those who received only nonthrust manipulation as part of an impairment-based, multimodal treatment program of manual physical therapy (MPT) and exercise for patients with mechanical neck pain.
BACKGROUND: A treatment regimen of MPT and exercise has been effective in patients with mechanical neck pain. Limited research has compared the effectiveness of cervical thrust manipulations and nonthrust mobilizations for this patient population, and no studies have investigated the added benefit of cervical thrust manipulations as part of an overall MPT treatment plan.
METHODS: Treatment outcomes from 47 patients in the treatment arm of a larger RCT with a primary complaint of mechanical neck pain, were analyzed. Twenty-three patients (49%) received cervical thrust manipulations as part of their MPT treatment, and 24 patients (51%) received only cervical nonthrust mobilizations. All patients received up to 6 clinic sessions, twice weekly for 3 weeks, and a home exercise program. Primary outcome measures were the Neck Disability Index (NDI), 2 visual analog scales for cervical and upper extremity pain, and a 15-point global rating of change scale. Blinded outcome measurements were collected at baseline and at 3-, 6- and 52-week follow-ups.
RESULTS: Consistent with the larger RCT, both subgroups in this secondary analysis demonstrated improvement in short- and long-term pain and disability scores. Low statistical power (beta <=.28) and the resultant small effect size indices (-0.21 to 0.17) preclude the identification of any between-group differences. No serious adverse reactions were reported by patients in either subgroup.
CONCLUSIONS: Clinically meaningful and statistically significant improvements in both subgroups of patients over time suggest that cervical thrust manipulation, as part of the MPT treatment plan, did not influence the results of the treatment arm of the larger RCT from which this study was drawn. Although no between-group differences can be identified, the small observed effect sizes in this study may benefit future studies with sample size estimation for larger RCTs and indicate the need to incorporate clinical prediction rule criteria as a means to improve statistical power.
C1 [Boyles, Robert E.] Univ Puget Sound, Sch Phys Therapy, Tacoma, WA 98416 USA.
[Walker, Michael J.] Baylor Univ, Doctoral Program Phys Therapy, USA, Ft Sam Houston, TX USA.
[Young, Brian A.] USAF, Sheppard AFB, TX USA.
[Strunce, Joseph B.] No Navajo Med Ctr, Rehabil Dept, Shiprock, NM USA.
[Wainner, Robert S.] Texas State Univ, Dept Phys Therapy, San Marcos, TX USA.
RP Boyles, RE (reprint author), Univ Puget Sound, Sch Phys Therapy, 1500 N Warner St,1070, Tacoma, WA 98416 USA.
EM bboyles@pugetsound.edu
NR 41
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U1 1
U2 13
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD MAR
PY 2010
VL 40
IS 3
BP 133
EP 140
DI 10.2519/jospt.2010.3106
PG 8
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 561CD
UT WOS:000274952100002
PM 20195023
ER
PT J
AU Elster, EA
Stojadinovic, A
Forsberg, J
Shawen, S
Andersen, RC
Schaden, W
AF Elster, Eric A.
Stojadinovic, Alexander
Forsberg, Jonathan
Shawen, Scott
Andersen, Romney C.
Schaden, Wolfgang
TI Extracorporeal Shock Wave Therapy for Nonunion of the Tibia
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE ESWT; nonunion; fracture
ID INTENSITY PULSED ULTRASOUND; CALCIFIC TENDINITIS; PLANTAR FASCIITIS;
CONTROLLED-TRIAL; SINGLE-BLIND; FRACTURES; BONE; SHOULDER; DEFECTS;
UNION
AB Objectives: Delayed and nonunion of the tibia are not uncommon in orthopaedic practice. Multiple methods of treatment have been developed with variable results. The objective of this study was to define disease-specific and treatment-related factors of prognostic significance in patients undergoing shock wave therapy for tibia nonunion.
Design: Retrospective analysis.
Patients: One hundred ninety-two patients treated with extracorporeal shock wave therapy (ESWT) at a single referral trauma center, AUVA-Trauma Center Meidling, a large single-referral trauma center located in Vienna, Austria, in an attempt to determine the feasibility and factors associated with the use of ESWT in the treatment for tibia nonunion.
Intervention: ESWT coupled with posttreatment immobilization, external fixation, or ESWT alone.
Main Outcome Measures: Fracture healing, overall healing percent, and factors associated with ESWT success or failure.
Results: At the time of last follow up, 138 of 172 (80.2%) patients have demonstrated complete fracture healing. Mean time from first shock wave therapy to complete healing of the tibia nonunion was 4.8 +/- 4.0 months. Number of orthopaedic operations (P = 0.003), shock wave treatments (P = 0.002), and pulses delivered (P = 0.04) were significantly associated with complete bone healing. Patients requiring multiple (more than one) shock wave treatments versus a single treatment had a significantly lower likelihood of fracture healing (P = 0.003). This may be attributable to the finding that a significantly greater proportion of patients with multiple rather than single ESWT treatments had three or more prior orthopaedic procedures (more than one ESWT, 63.9% versus one ESWT, 23.5%; P < 0.001).
Conclusions: ESWT is a feasible treatment modality for tibia nonunion.
C1 [Elster, Eric A.] NNMC Bethesda, NMRC, Dept Surg, Silver Spring, MD 20910 USA.
[Elster, Eric A.; Forsberg, Jonathan] Natl Naval Med Ctr, Combat Wound Initiat, Bethesda, MD USA.
[Stojadinovic, Alexander] Walter Reed Army Med Ctr, Combat Wound Initiat, Washington, DC 20307 USA.
[Schaden, Wolfgang] AUVA Trauma Ctr Meidling, Vienna, Austria.
[Shawen, Scott; Andersen, Romney C.] Walter Reed Army Med Ctr, Orthopaed Surg Serv, Washington, DC 20307 USA.
[Forsberg, Jonathan] Natl Naval Med Ctr, Dept Orthopaed Surg, Bethesda, MD USA.
RP Elster, EA (reprint author), NNMC Bethesda, NMRC, Dept Surg, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM eric.elster@med.navy.mil
NR 52
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U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD MAR
PY 2010
VL 24
IS 3
BP 133
EP 141
DI 10.1097/BOT.0b013e3181b26470
PG 9
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA 564DK
UT WOS:000275193300001
PM 20182248
ER
PT J
AU Mishchenko, MI
Zakharova, NT
Videen, G
Khlebtsov, NG
Wriedt, T
AF Mishchenko, Michael I.
Zakharova, Nadia T.
Videen, Gorden
Khlebtsov, Nikolai G.
Wriedt, Thomas
TI Comprehensive T-matrix reference database: A 2007-2009 update
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Review
DE Electromagnetic scattering; T-matrix method
ID ELECTROMAGNETIC-WAVES SCATTERING; CORE-SATELLITE NANOASSEMBLIES;
LAGUERRE-GAUSSIAN BEAMS; LIGHT-SCATTERING; NONSPHERICAL PARTICLES;
OPTICAL-PROPERTIES; POLARIMETRIC-RADAR; EXPERIMENTAL-VERIFICATION; GOLD
NANOPARTICLES; BIOLOGICAL TISSUE
AB The T-matrix method is among the most versatile, efficient, and widely used theoretical techniques for the numerically exact computation of electromagnetic scattering by homogeneous and composite particles, clusters of particles, discrete random media, and particles in the vicinity of an interface separating two half-spaces with different refractive indices. This paper presents an update to the comprehensive database of T-matrix publications compiled by us previously and includes the publications that appeared since 2007. It also lists several earlier publications not included in the original database. Published by Elsevier Ltd.
C1 [Mishchenko, Michael I.] NASA, Goddard Inst Space Studies, New York, NY 10025 USA.
[Zakharova, Nadia T.] Sigma Space Partners, New York, NY 10025 USA.
[Videen, Gorden] USA, Res Lab, AMSRL IS EE, Adelphi, MD 20783 USA.
[Khlebtsov, Nikolai G.] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, Saratov 410015, Russia.
[Wriedt, Thomas] Inst Werkstofftech, D-28359 Bremen, Germany.
RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA.
EM mmishchenko@giss.nasa.gov
RI Mishchenko, Michael/D-4426-2012; Khlebtsov, Nikolai/D-6199-2017; Pylaev,
Timofey/A-8401-2016;
OI Pylaev, Timofey/0000-0002-2701-3333; Khlebtsov,
Nikolai/0000-0002-2055-7784
FU NASA
FX We thank Josefina Mora and Zoe Wai for helping to obtain copies of
publications that were not readily accessible. This project was
sponsored by the NASA Radiation Sciences Program managed by Hal Mating.
NR 259
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U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD MAR
PY 2010
VL 111
IS 4
BP 650
EP 658
DI 10.1016/j.jqsrt.2009.11.002
PG 9
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA 549QY
UT WOS:000274069900012
ER
PT J
AU Berg, MJ
Sorensen, CM
Chakrabarti, A
AF Berg, M. J.
Sorensen, C. M.
Chakrabarti, A.
TI Explanation of the patterns in Mie theory
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Electromagnetic scattering; Light scattering; Mie theory; Guinier law;
Porod law; Phase function
ID LIGHT-SCATTERING; SPHERES; FIELD; PARTICLES; RESONANCE
AB The far-field scattered light intensity, or the related phase function, for a spherical particle is known to display an overall power-law structure when formulated in terms of the scattering wave vector. Empirically determined patterns in the intensity relating to the particle size and refractive index are known. The cause of the patterns, however, has not been satisfactorily explained. This work applies an exact microphysical model to explain most of the patterns, and specifically, to reveal the physical cause of crossovers from one power-law to another. A unique aspect of this microphysical approach is phasor analysis, which provides a visually based way to examine the angle-dependent wavelet superposition involved in the model A simple color coding scheme connects the phasors to the interior of the particle. and it is this connection that reveals the meaning of the crossovers. (C) 2009 Elsevier Ltd. All rights reserved
C1 [Sorensen, C. M.; Chakrabarti, A.] Kansas State Univ, Dept Phys, Manhattan, KS 66506 USA.
[Berg, M. J.] USA, Res Lab, RDRL CIE S, Adelphi, MD 20783 USA.
RP Sorensen, CM (reprint author), Kansas State Univ, Dept Phys, Cardwell Hall, Manhattan, KS 66506 USA.
RI Sorensen, Christopher/G-4900-2013
OI Sorensen, Christopher/0000-0002-1980-3394
FU National Research Council; United States Defense Threat Reduction Agency
[DAAD17-03-C-0070]
FX This work was partly supported by the National Research Council
postdoctoral associateship program funded by the United States Defense
Threat Reduction Agency, Contract no. DAAD17-03-C-0070.
NR 36
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U1 2
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD MAR
PY 2010
VL 111
IS 5
BP 782
EP 794
DI 10.1016/j.jqsrt.2009.11.010
PG 13
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA 562RB
UT WOS:000275070100010
ER
PT J
AU Kortan, N
Roberts, J
Roebuck, J
AF Kortan, Nicholas
Roberts, Jefferson
Roebuck, Jonathan
TI Gout Masquerading as a Triquetral Fracture
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Editorial Material
C1 [Kortan, Nicholas; Roberts, Jefferson; Roebuck, Jonathan] Walter Reed Army Med Ctr, Dept Rheumatol, Washington, DC 20307 USA.
RP Kortan, N (reprint author), Walter Reed Army Med Ctr, Dept Rheumatol, Bldg 2,6900 Georgia Ave NW, Washington, DC 20307 USA.
EM Nicholas.kortan@amedd.army.mil
NR 3
TC 1
Z9 2
U1 0
U2 0
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADA
SN 0315-162X
J9 J RHEUMATOL
JI J. Rheumatol.
PD MAR
PY 2010
VL 37
IS 3
BP 670
EP 671
DI 10.3899/jrheum.091000
PG 2
WC Rheumatology
SC Rheumatology
GA 563MD
UT WOS:000275135700033
PM 20197566
ER
PT J
AU Romasco, AL
Friedman, LH
Fang, L
Meirom, RA
Clark, TC
Polcawich, R
Pulskamp, J
Dubey, M
Muhlstein, CL
AF Romasco, A. L.
Friedman, L. H.
Fang, L.
Meirom, R. A.
Clark, T. C.
Polcawich, R.
Pulskamp, J.
Dubey, M.
Muhlstein, C. L.
TI Practical Implications of Instrument Displacement Drift during
Force-Controlled Nanoindentation
SO JOURNAL OF TESTING AND EVALUATION
LA English
DT Article
DE Instrumented indentation; nanoindentation; drift
ID DEPTH-SENSING INDENTATION; THIN-FILMS; MECHANICAL-PROPERTIES;
SURFACE-ROUGHNESS; STRAIN-RATE; HARDNESS; MODULUS; CREEP
AB The accuracy of instrumented indentation data relies heavily on the evaluation of experimental errors such as displacement drift. In spite of its importance, little attention has been given to the magnitude of an acceptable displacement drift rate, its relationship to a given set of test conditions, and how errors manifest themselves in force-displacement data. In this work we explored how drift rates that were acceptable for short-term tests caused artificial "abnormal" behavior that could have been interpreted as a true material response for a longer-term test. A critical review of the drift behavior of the nanoindentation system revealed that a useful metric for screening data quality was the nominal accumulated system drift as a fraction of the maximum penetration depth. Additionally, suggestions for drift management during nanoindentation tests were given.
C1 [Romasco, A. L.; Meirom, R. A.; Muhlstein, C. L.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Polcawich, R.; Pulskamp, J.; Dubey, M.] USA, Res Lab, Adelphi, MD 20783 USA.
[Clark, T. C.] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA.
[Friedman, L. H.; Fang, L.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA.
RP Muhlstein, CL (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
EM clm28@psu.edu
RI Friedman, Lawrence/G-5650-2011
OI Friedman, Lawrence/0000-0003-2416-9903
FU U.S. Army Research Office [ARO 48355EG]; National Science Foundation
[0528234, 0335765]; Pennsylvania State University Materials Research
Institute NanoFabrication Network; National Nanotechnology
Infrastructure Network, Cornell University
FX The writers acknowledge the support of the U.S. Army Research Office
(Grant No. ARO 48355EG, program manager Dr. Bruce La-Mattina) and the
National Science Foundation (CMS Program No. 0528234, program manager
Dr. Ken Chong). The writers would also like to thank the contributions
of Prashant Ranade of General Technical Services for his role in the
fabrication of the platinum thin films. This work was also supported by
the Pennsylvania State University Materials Research Institute
NanoFabrication Network and the National Science Foundation Cooperative
Agreement No. 0335765, and National Nanotechnology Infrastructure
Network, with Cornell University. Any opinions, findings, and
conclusions or recommendations expressed in this publication are those
of the writer(s) and do not necessarily reflect the views of Cornell
University nor those of the National Science Foundation.
NR 24
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U1 0
U2 4
PU AMER SOC TESTING MATERIALS
PI W CONSHOHOCKEN
PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA
SN 0090-3973
EI 1945-7553
J9 J TEST EVAL
JI J. Test. Eval.
PD MAR
PY 2010
VL 38
IS 2
BP 203
EP 210
DI 10.1520/JTE102177
PG 8
WC Materials Science, Characterization & Testing
SC Materials Science
GA 570OE
UT WOS:000275686800009
ER
PT J
AU Albert, DG
Liu, LB
AF Albert, Donald G.
Liu, Lanbo
TI The effect of buildings on acoustic pulse propagation in an urban
environment
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID SOUND-PROPAGATION; STREET CANYONS; NOISE; MEDIA; AREAS; MODEL
AB Experimental measurements were conducted using acoustic pulse sources in a full-scale artificial village to investigate the reverberation, scattering, and diffraction produced as acoustic waves interact with buildings. These measurements show that a simple acoustic source pulse is transformed into a complex signature when propagating through this environment, and that diffraction acts as a low-pass filter on the acoustic pulse. Sensors located in non-line-of-sight (NLOS) positions usually recorded lower positive pressure maxima than sensors in line-of-sight positions. Often, the first arrival on a NLOS sensor located around a corner was not the largest arrival, as later reflection arrivals that traveled longer distances without diffraction had higher amplitudes. The waveforms are of such complexity that human listeners have difficulty identifying replays of the signatures generated by a single pulse, and the usual methods of source location based on the direction of arrivals may fail in many cases. Theoretical calculations were performed using a two-dimensional finite difference time domain (FDTD) method and compared to the measurements. The predicted peak positive pressure agreed well with the measured amplitudes for all but two sensor locations directly behind buildings, where the omission of rooftop ray paths caused the discrepancy. The FDTD method also produced good agreement with many of the measured waveform characteristics. (C) 2010 Acoustical Society of America. [DOI: 10.1121/1.3277245]
C1 [Albert, Donald G.] USA, Erdc, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Liu, Lanbo] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA.
RP Albert, DG (reprint author), USA, Erdc, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
FU PM-CCS; U.S. Army Corps of Engineers Engineering Research and
Development Center
FX We thank the late Mr. Rich Andrejkovics and Mr. Andre Edwin, SYDET
Project Officer of PM-CCS, for funding the experimental measurements
presented here. This paper is dedicated to Rich's memory. The analysis
was funded by the U.S. Army Corps of Engineers Engineering Research and
Development Center research program. We also thank the many people who
assisted with the field measurements, including David Carbee, Stephen
Decato, and Dr. Joyce Nagle (ERDC-CRREL); Chris Reiff and Herb Brann
(Army Research Laboratory); Gary Leadore, George Eason, Thomas Ruffing,
Patrick Whaling, and James Aguiar (Aberdeen Test Center); Ron Akers,
Stan Ellis, George Eason, and others from Fort Benning. In addition,
Major Joseph Haydon (U.S. Army) assisted with the measurement design,
Dr. Joyce Nagle conducted a review of the urban acoustic literature used
in this paper, and David Leese (ERDC-ITL) provided meteorological data.
We also thank two anonymous reviewers for useful comments that improved
the manuscript.
NR 29
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U2 12
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD MAR
PY 2010
VL 127
IS 3
BP 1335
EP 1346
DI 10.1121/1.3277245
PN 1
PG 12
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 573TO
UT WOS:000275938000025
PM 20329833
ER
PT J
AU Thorne, DR
AF Thorne, David R.
TI THE IDENTIFIES HIDDEN IN THE MATCHING LAWS, AND THEIR USES
SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
LA English
DT Article
DE matching; law; compound schedules; concurrent schedules; identity;
tautology; behavioral economics; foraging
ID QUANTITATIVE-ANALYSIS; CONCURRENT CHOICE; REINFORCEMENT; SCHEDULES;
RESPONSES
AB Various theoretical equations have been proposed to predict response rate as a function of the rate of reinforcement. If both the rate and probability of reinforcement are considered, a simple identity, defining equation, or "law" holds. This identity places algebraic constraints on the allowable forms of our mathematical models and can help identify the referents for certain empirical or theoretical coefficients. This identity can be applied to both single and compound schedules of reinforcement, absolute and relative measures, and to local, global and overall rates and probabilities. The rate matching equations of Hernstein and Catania appear to have been approximations to, and to have been evolving toward, one form of this algebraic identity. Estimates of the bias and sensitivity terms in the generalized ratio and logarithmic matching models are here held to be averaging artifacts arising from fitting procedures applied to models that violate or conceal the underlying identities.
C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, Silver Spring, MD 20910 USA.
RP Thorne, DR (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM david.thorne@us.army.mil
NR 22
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U1 1
U2 2
PU SOC EXP ANALYSIS BEHAVIOR INC
PI BLOOMINGTON
PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 USA
SN 0022-5002
J9 J EXP ANAL BEHAV
JI J. Exp. Anal. Behav.
PD MAR
PY 2010
VL 93
IS 2
BP 247
EP 260
DI 10.1901/jeab.2010.93-247
PG 14
WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental
SC Psychology; Behavioral Sciences
GA 566PH
UT WOS:000275384500007
PM 20885813
ER
PT J
AU Teague, NS
Srijan, A
Wongstitwilairoong, B
Poramathikul, K
Champathai, T
Ruksasiri, S
Pavlin, J
Mason, CJ
AF Teague, Nathan S.
Srijan, Apichai
Wongstitwilairoong, Boonchai
Poramathikul, Kamonporn
Champathai, Thanaporn
Ruksasiri, Supaporn
Pavlin, Julie
Mason, Carl J.
TI Enteric Pathogen Sampling of Tourist Restaurants in Bangkok, Thailand
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Article
ID ARCOBACTER-BUTZLERI; TRAVELERS DIARRHEA; ANTIBIOTIC-RESISTANCE;
FOODBORNE DISEASE; RETAIL FOODS; CAMPYLOBACTER; PREVALENCE;
EPIDEMIOLOGY; RISK; SPP.
AB Methods. A cross-sectional tourist restaurant survey was conducted. Thirty-five restaurants recommended in the two top selling Bangkok guidebooks on Amazon.com were sampled for bacterial pathogens known to cause diarrhea in Thailand, namely Salmonella, Campylobacter, and Arcobacter (a Campylobacter-like organism). A total of 70 samples from two meals at each restaurant were obtained. Suspected bacterial pathogens were isolated by differential culture and tested for antibiotic resistance.
Results. Salmonella group E was isolated from one meal (2%), and Arcobacter butzleri from nine meals (13%). Campylobacter spp. were not found. The large majority of A butzleri isolates were resistant to azithromycin but susceptible to ciprofloxacin and an aminoglycoside.
Conclusions. A traveler's risk of exposure to established bacterial pathogens, Salmonella and Campylobacter, by eating in recommended restaurants is small. Arcobacter butzleri exposure risk is 13% per meal eaten, and rises to 75% when 10 meals are eaten. All restaurants, regardless of price, appear to be equally "risky." Current evidence points to Arcobacter being pathogenic in humans; however, further research is needed to conclusively define pathogenicity. Routine prophylaxis for diarrhea is not recommended; however, travelers should be aware of the risk and come prepared with adequate and appropriate self-treatment medications.
C1 [Teague, Nathan S.] Madigan Army Med Ctr, Dept Prevent Med, Ft Lewis, WA 98431 USA.
[Srijan, Apichai; Wongstitwilairoong, Boonchai; Poramathikul, Kamonporn; Champathai, Thanaporn; Ruksasiri, Supaporn; Pavlin, Julie; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
RP Teague, NS (reprint author), Madigan Army Med Ctr, Dept Prevent Med, Bldg 9920, Ft Lewis, WA 98431 USA.
EM nathan.teague@us.army.mil
RI Valle, Ruben/A-7512-2013;
OI MASON, CARL/0000-0002-3676-2811
FU US Department of Defense; Global Emerging Infections Surveillance and
Response System; Overseas Tropical Medicine Training Program
FX Special thanks to AFRIMS staff for technical support. Financial support
for travel was obtained through the US Department of Defense, Global
Emerging Infections Surveillance and Response System, Overseas Tropical
Medicine Training Program. This study was exempt from Human
Investigation Committee review under the following part of the US
federal regulations: 45 CFR Part 46.101(b)(4). This study is not a
clinical trial and does not need to be registered.
NR 42
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U1 0
U2 4
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1195-1982
J9 J TRAVEL MED
JI J. Travel Med.
PD MAR-APR
PY 2010
VL 17
IS 2
BP 118
EP 123
DI 10.1111/j.1708-8305.2009.00388.x
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 563DD
UT WOS:000275106600008
PM 20412179
ER
PT J
AU Sears, CLG
Lewis, C
Noel, K
Albright, TS
Fischer, JR
AF Sears, Christine L. G.
Lewis, Christa
Noel, Kathleen
Albright, Todd S.
Fischer, John R.
TI Overactive Bladder Medication Adherence When Medication is Free to
Patients
SO JOURNAL OF UROLOGY
LA English
DT Article
DE urinary bladder, overactive; muscarinic antagonists; delivery of health
care; military personnel; medication adherence
ID POPULATION; PERSISTENCE; EXPERIENCE; SYMPTOMS; RELEASE
AB Purpose: We examined overactive bladder medication compliance in a health care system in which patients do not pay for medication.
Materials and Methods: Pharmacy dispensing records were reviewed for anti-muscarinic agents from January 2003 to December 2006 for the United States Military Health System National Capital Region. Medication nonpersistence, switching and adherence were examined. Kaplan-Meier survival analysis was done to compare medication persistence duration.
Results: Overactive bladder medications were dispensed to 7,879 adults. Tolterodine extended release (4,716 patients or 60%) and oxybutynin immediate release (2,003 or 25.5%) were most commonly prescribed. The medication nonpersistence rate, defined as the proportion of patients who never refilled a prescription for antimuscarinics during the study period, was 35.1% (2,760 of 7,858). Of 5,098 patients who refilled a prescription 1,305 changed the medication or dose at least once for a medication switch rate of 25.6%. The overall median medication possession ratio, defined as the total days of medication dispensed except for the last refill divided by the number of days between the first dispense date and the last refill date, was 0.82 in all cases. Men had a significantly higher median medication possession ratio than women (0.86 vs 0.81, p <0.001). Of patients who obtained at least 1 refill women remained on medication longer than men (median 606 vs 547 days, p = 0.01). Patients on tolterodine extended release had a higher medication nonpersistence rate than those on oxybutynin immediate release (0.89 vs 0.68, p <0.01). There was no difference between extended release medications.
Conclusions: In a health care system in which patients do not pay for medications 35% of patients did not refill a prescription for overactive bladder medication, similar to previous reports. However, other measures of medication compliance were higher than those published previously in systems with copays.
C1 [Sears, Christine L. G.] Natl Naval Med Ctr, Dept Urol, Bethesda, MD 20889 USA.
[Sears, Christine L. G.; Noel, Kathleen; Albright, Todd S.; Fischer, John R.] Walter Reed Army Med Ctr, Natl Capitol Consortium Fellowship Female Pelv Me, Washington, DC 20307 USA.
[Lewis, Christa; Albright, Todd S.; Fischer, John R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Sears, CLG (reprint author), Natl Naval Med Ctr, Dept Urol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM Christine.Sears@med.navy.mil
NR 13
TC 36
Z9 37
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5347
J9 J UROLOGY
JI J. Urol.
PD MAR
PY 2010
VL 183
IS 3
BP 1077
EP 1081
DI 10.1016/j.juro.2009.11.026
PG 5
WC Urology & Nephrology
SC Urology & Nephrology
GA 558NJ
UT WOS:000274750100097
PM 20092838
ER
PT J
AU Sanamyan, T
Simmons, J
Dubinskii, M
AF Sanamyan, T.
Simmons, J.
Dubinskii, M.
TI Er3+-doped Y2O3 ceramic laser at similar to 2.7 mu m with direct diode
pumping of the upper laser level
SO LASER PHYSICS LETTERS
LA English
DT Article
DE solid-state laser; diode pumped; Er-doped laser; mid-IR laser
ID MULTIPHONON RELAXATION; TEMPERATURE; EMISSION; YAG; CW
AB We report relevant spectroscopy and efficient diode-pumped similar to 2.7-mu m laser operation of Er3+:Y2O3 ceramic resonantly pumped into upper laser level I-4(11/2). This is believed to be the first laser demonstration based on I-4(11/2) -> I-4(13/2) transitions of Er3+ in Y2O3.
[GRAPHICS]
Effective room temperature emission cross section of Er 31 ions in Er3+(0.5 at.%):Y2O3 laser ceramic derived from measured (C) 2010 by Astro Ltd. Published exclusively by WILEY-VCH Verlag GmbH & Co. KGaA
C1 [Sanamyan, T.; Simmons, J.; Dubinskii, M.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA.
RP Dubinskii, M (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM mdubinskiy@arl.army.mil
NR 13
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Z9 19
U1 1
U2 14
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1612-2011
EI 1612-202X
J9 LASER PHYS LETT
JI Laser Phys. Lett.
PD MAR
PY 2010
VL 7
IS 3
BP 206
EP 209
DI 10.1002/lapl.200910132
PG 4
WC Optics; Physics, Applied
SC Optics; Physics
GA 568MC
UT WOS:000275525500005
ER
PT J
AU Burgess, EB
AF Burgess, Edwin B.
TI America's Captives: Treatment of POWs from the Revolutionary War to the
War on Terror
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin B.] USA, Combines Arms Res Lib, Ft Leavenworth, KS USA.
RP Burgess, EB (reprint author), USA, Combines Arms Res Lib, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD MAR 1
PY 2010
VL 135
IS 4
BP 90
EP 90
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 565EW
UT WOS:000275273000123
ER
PT J
AU Burgess, EB
AF Burgess, Edwin B.
TI The Enemy in Our Hands: America's Treatment of Prisoners of War from the
Revolution to the War on Terror
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA.
RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD MAR 1
PY 2010
VL 135
IS 4
BP 90
EP 90
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA 565EW
UT WOS:000275273000122
ER
PT J
AU Kondoh, K
Hamada, ESA
Imai, H
Umeda, J
Jones, T
AF Kondoh, Katsuyoshi
Hamada, El-Sayed Ayman
Imai, Hisashi
Umeda, Junko
Jones, Tyrone
TI Microstructures and mechanical responses of powder metallurgy
non-combustive magnesium extruded alloy by rapid solidification process
in mass production
SO MATERIALS & DESIGN
LA English
DT Article
ID CAST MG; BEHAVIOR; TEMPERATURE; EXTRUSION; STRENGTH
AB Spinning Water Atomization Process (SWAP), which was one of the rapid solidification processes, promised to produce coarse non-combustible magnesium alloy powder with 1-4 mm length, having fine alpha-Mg grains and Al(2)Ca intermetallic compounds. It had economical and safe benefits in producing coarse Mg alloy powders with very fine microstructures in the mass production process due to its extreme high solidification rate compared to the conventional atomization process. AMX602 (Mg-6%Al-0.5%Mn-2%Ca) powders were compacted at room temperature. Their green compacts with a relative density of about 85% were heated at 573-673 K for 300 s in Ar gas atmosphere, and immediately consolidated by hot extrusion. Microstructure observation and evaluation of mechanical properties of the extruded AMX602 alloys were carried out. The uniform and fine microstructures with grains less than 0.45-0.8 mu m via dynamic recrystallization during hot extrusion were observed, and were much small compared to the extruded AMX602 alloy fabricated by using cast ingot. The extremely fine intermetallic compounds 200-500 nm diameter were uniformly distributed in the matrix of powder metallurgy (P/M) extruded alloys. These microstructures caused excellent mechanical properties of the wrought alloys. For example, in the case of AMX602 alloys extruded at 573 K, the tensile strength (TS) of 447 MPa, yield stress (YS) of 425 MlPa and 9.6% elongation were obtained. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
C1 [Kondoh, Katsuyoshi; Hamada, El-Sayed Ayman; Imai, Hisashi; Umeda, Junko] Osaka Univ, Joining & Welding Res Inst, Osaka 5670047, Japan.
[Jones, Tyrone] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Kondoh, K (reprint author), Osaka Univ, Joining & Welding Res Inst, 11-1 Mihogaoka, Osaka 5670047, Japan.
EM kondoh@jwri.osaka-u.ac.jp
OI Elsayed, Ayman/0000-0002-1116-5527
NR 23
TC 11
Z9 12
U1 3
U2 17
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0261-3069
J9 MATER DESIGN
JI Mater. Des.
PD MAR
PY 2010
VL 31
IS 3
BP 1540
EP 1546
DI 10.1016/j.matdes.2009.10.001
PG 7
WC Materials Science, Multidisciplinary
SC Materials Science
GA 551JE
UT WOS:000274203200061
ER
PT J
AU Stephenson, LD
Bailey, D
Kumar, A
Hock, V
AF Stephenson, L. D.
Bailey, David
Kumar, Ashok
Hock, Vincent
TI Polyurea Coatings for Rehabilitation of Metal Roofing
SO MATERIALS PERFORMANCE
LA English
DT Article
AB Higb-build plural-component polyurea-hybrid spray-on coatings quickly and cost-effectively rehabilitate metal roofs. A badly degraded aluminum alloy roof at an Army airfield was chosen for rehabilitation. The polyurea-hybrid coating was economical to apply, and is expected to the service life of the metal roof by providing a very tough moisture impermeable spray-on membrane. It effectively seals surface defects, even around penetrations, pinholes, and seams.
C1 [Stephenson, L. D.; Bailey, David; Kumar, Ashok; Hock, Vincent] USA, ERDC, CERL, Champaign, IL 61826 USA.
RP Stephenson, LD (reprint author), USA, ERDC, CERL, POB 9005, Champaign, IL 61826 USA.
NR 9
TC 1
Z9 1
U1 1
U2 14
PU NATL ASSOC CORROSION ENG
PI HOUSTON
PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA
SN 0094-1492
J9 MATER PERFORMANCE
JI Mater. Perform.
PD MAR
PY 2010
VL 49
IS 3
BP 47
EP 53
PG 7
WC Materials Science, Characterization & Testing
SC Materials Science
GA 570TW
UT WOS:000275702000012
ER
PT J
AU Marr, LC
Ely, MR
AF Marr, Linsey C.
Ely, Matthew R.
TI Effect of Air Pollution on Marathon Running Performance
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE ATHLETIC PERFORMANCE; EXERCISE; LUNG FUNCTION; SEX; PM(10); WEATHER
ID PULMONARY-FUNCTION; OZONE EXPOSURE; PARTICLE DEPOSITION; LUNG-FUNCTION;
EXERCISE; ADULTS; NASAL; SCHOOLCHILDREN; DIOXIDE; OUTDOOR
AB MARR, L. C. and M. R. ELY. Effect of Air Pollution on Marathon Running Performance. Med. Sci. Sports Exerc., Vol. 42, No. 3, pp. 585-591, 2010. Before the 2008 Olympic Games, there was concern that air pollution in Beijing would affect the performance of marathon runners. Air pollutant concentrations during marathon running and their effect on performance have not been reported. Evidence suggests that the lung function of females may be more susceptible than that of males to air pollution, but it is uncertain if this translates to decreased marathon performance. Purpose: The purposes of this study were to 1) describe ambient air pollutant concentrations present during major US marathons, 2) quantify performance decrements associated with air pollutants, and 3) examine potential sex difference in performance related to air pollutants. Methods: Marathon race results, weather data, and air pollutant concentrations were obtained for seven marathons for 8-28 yr. The top three male and female finishing times were compared with the course record and contrasted with air pollutant levels and wet bulb globe temperature (WBGT). A WBGT-adjusted performance decrement was calculated, and regression analysis was used to quantify performance decrements associated with pollutants. Results: The air pollutant concentrations of carbon monoxide, ozone, particulate matter smaller than 10 mu m (PM(10)), PM(2.5), nitrogen dioxide, and sulfur dioxide ranged from 0 to 5.9 ppm, from 0 to 0.07 ppm, from 4.5 to 41.0 mu g.m(-3), from 2.8 to 42.0 mu g.m(-3), from 0 to 0.06 ppm, and from 0 to 0.05 ppm, respectively. After adjusting for WBGT-associated performance decrements, only PM(10) was associated with decrements in performance of women. For every 10-mu g.m(-3) increase in PM(10), performance can be expected to decrease by 1.4%. Conclusions: The concentrations of air pollution present during marathons rarely exceed health-based national standards and levels known to affect lung function in laboratory situations. Regardless, PM(10) was significantly correlated with performance of women marathon runners.
C1 [Marr, Linsey C.] Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA.
[Ely, Matthew R.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
RP Marr, LC (reprint author), Virginia Tech, Dept Civil & Environm Engn, 411 Durham Hall 0246, Blacksburg, VA 24061 USA.
EM lmarr@vt.edu
RI Marr, Linsey/C-9698-2010; Lucas, Elizabeth/E-2733-2010;
OI Marr, Linsey/0000-0003-3628-6891; Ely, Matthew/0000-0002-0618-7078
FU National Science Foundation's Advance program at Virginia Tech
FX This work was supported by the National Science Foundation's Advance
program at Virginia Tech. The authors thank TSgt Michael Ross (AFCCC),
Jack Fleming (Boston Athletic Association), Shane Bauer (Grandma's
Marathon), Will Nicholson (MS4 University of Minnesota Medical School),
Myles Killar (Virginia Tech), and Nick Mangus (US EPA) for their
assistance.; The opinions or assertions contained herein are the private
views of the authors and are not to be construed as official or
reflecting the views of the Army or the Department of Defense. Any
citations of commercial organizations and trade names in this report do
not constitute an official Department of the Army endorsement or
approval of the products or services of these organizations. The authors
do not have any relationships to disclose that would cause a conflict of
interests. The results of the present study do not constitute
endorsement by the American College of Sports Medicine.
NR 38
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U1 7
U2 32
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAR
PY 2010
VL 42
IS 3
BP 585
EP 591
DI 10.1249/MSS.0b013e3181b84a85
PG 7
WC Sport Sciences
SC Sport Sciences
GA 565VY
UT WOS:000275324600025
PM 19952812
ER
PT J
AU Mirotznik, MS
Good, B
Ransom, P
Wikner, D
Mait, JN
AF Mirotznik, Mark S.
Good, Brandon
Ransom, Paul
Wikner, David
Mait, Joseph N.
TI ITERATIVE DESIGN OF MOTH-EYE ANTIREFLECTIVE SURFACES AT MILLIMETER WAVE
FREQUENCIES
SO MICROWAVE AND OPTICAL TECHNOLOGY LETTERS
LA English
DT Article
DE diffractive; subwavelength; antireflective; millimeter wave; motheye
ID BINARY GRATINGS; BAND
AB A method for synthesizing broadband antireflective (AR) surfaces at millimeter wave frequencies is demonstrated AR surfaces were formed by machining a multilayer subwavelength structures Into nonabsorptive dielectrics. This created low-reflected energies (<-25 dB) over large bandwidths and incidence angles Experimental results are provided demonstrating the validity of the method. (C) 2010 Wiley Periodicals, Inc Microwave Opt Technol Lett 52 561-568, 2010. Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/mop.24973
C1 [Mirotznik, Mark S.; Good, Brandon] Catholic Univ Amer, Dept Elect Engn & Comp Sci, Washington, DC 20064 USA.
[Ransom, Paul] USN, Ctr Surface Warfare, Carderock Div, Bethesda, MD 20817 USA.
[Wikner, David; Mait, Joseph N.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Mirotznik, MS (reprint author), Catholic Univ Amer, Dept Elect Engn & Comp Sci, 620 Michigan Ave NE, Washington, DC 20064 USA.
NR 15
TC 3
Z9 3
U1 1
U2 10
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0895-2477
J9 MICROW OPT TECHN LET
JI Microw. Opt. Technol. Lett.
PD MAR
PY 2010
VL 52
IS 3
BP 561
EP 568
DI 10.1002/mop.24973
PG 8
WC Engineering, Electrical & Electronic; Optics
SC Engineering; Optics
GA 553JW
UT WOS:000274363700018
ER
PT J
AU Breloski, JT
AF Breloski, Jeffrey T.
TI "SOS": SAVE OUR SERVICE MARKS
SO MILITARY LAW REVIEW
LA English
DT Article
C1 USA, Cent Command, Ft McPherson, GA USA.
RP Breloski, JT (reprint author), USA, Cent Command, Ft McPherson, GA USA.
NR 19
TC 0
Z9 0
U1 0
U2 0
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SPR
PY 2010
VL 203
BP 78
EP 148
PG 71
WC Law
SC Government & Law
GA 635KF
UT WOS:000280653300002
ER
PT J
AU Gregory, EJ
AF Gregory, E. John
TI TRYING UNLAWFUL COMBATANTS AT GENERAL COURTS-MARTIAL: AMENDING THE UCMJ
IN LIGHT OF THE MILITARY COMMISSIONS EXPERIENCE
SO MILITARY LAW REVIEW
LA English
DT Article
ID TERRORISM; DETENTION
C1 [Gregory, E. John] USA, Washington, DC 20310 USA.
RP Gregory, EJ (reprint author), US Forces Iraq, Victory Base Complex, Baghdad, Iraq.
NR 38
TC 0
Z9 0
U1 0
U2 0
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SPR
PY 2010
VL 203
BP 150
EP 188
PG 39
WC Law
SC Government & Law
GA 635KF
UT WOS:000280653300003
ER
PT J
AU Borch, FL
AF Borch, Fred L., III
TI THE HISTORY OF "DON'T ASK, DON'T TELL" IN THE ARMY: HOW WE GOT TO IT AND
WHY IT IS WHAT IT IS
SO MILITARY LAW REVIEW
LA English
DT Article
ID POLICY
RP Borch, FL (reprint author), USA, Judge Advocate Gens Corps, Judge Advocate Gens Legal Ctr & Sch TJAGLCS, Charlottesville, VA USA.
NR 35
TC 3
Z9 3
U1 0
U2 0
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SPR
PY 2010
VL 203
BP 189
EP 206
PG 18
WC Law
SC Government & Law
GA 635KF
UT WOS:000280653300004
ER
PT J
AU Bunn, SA
AF Bunn, Sherilyn A.
TI STRAIGHT TALK: THE IMPLICATIONS OF REPEALING "DON'T ASK, DON'T TELL" AND
THE RATIONALE FOR PRESERVING ASPECTS OF THE CURRENT POLICY
SO MILITARY LAW REVIEW
LA English
DT Article
ID MEN
C1 USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA.
RP Bunn, SA (reprint author), USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Legal Ctr & Sch, Charlottesville, VA USA.
NR 106
TC 6
Z9 6
U1 0
U2 1
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SPR
PY 2010
VL 203
BP 207
EP 283
PG 77
WC Law
SC Government & Law
GA 635KF
UT WOS:000280653300005
ER
PT J
AU Kesler, LR
AF Kesler, Laura R.
TI SERVING WITH INTEGRITY: THE RATONALE FOR THE REPEAL OF "DON'T ASK, DON'T
TELL" AND ITS BAN ON ACKNOWLEDGED HOMOSEXUALS IN THE ARMED FORCES
SO MILITARY LAW REVIEW
LA English
DT Article
ID UNITED-STATES; MILITARY; INTEGRATION; WOMEN
C1 USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Sch, Charlottesville, VA USA.
RP Kesler, LR (reprint author), USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gens Sch, Charlottesville, VA USA.
NR 156
TC 5
Z9 5
U1 0
U2 4
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SPR
PY 2010
VL 203
BP 284
EP 380
PG 97
WC Law
SC Government & Law
GA 635KF
UT WOS:000280653300006
ER
PT J
AU Bedno, SA
Lang, CE
Daniell, WE
Wiesen, AR
Datu, B
Niebuhr, DW
AF Bedno, Sheryl A.
Lang, Christine E.
Daniell, William E.
Wiesen, Andrew R.
Datu, Bennett
Niebuhr, David W.
TI Association of Weight at Enlistment With Enrollment in the Army Weight
Control Program and Subsequent Attrition in the Assessment of Recruit
Motivation and Strength Study
SO MILITARY MEDICINE
LA English
DT Article
ID STATE-SPECIFIC PREVALENCE; UNITED-STATES; OBESITY; ADULTS; OVERWEIGHT;
MILITARY
AB The ongoing obesity epidemic has made recruiting qualified Army applicants increasingly difficult. A cohort of 10,213 Army enlisted subjects was enrolled in the Assessment of Recruit Motivation and Strength (ARMS) study from February 2005 through September 2006. Overweight recruits obtained a waiver for enlistment (n = 990) if they passed a screening physical fitness test. Recruits were evaluated for enrollment into the Army Weight Control Program (AWCP) and discharged during the 15 months following enlistment. Enrollment was higher among overweight recruits than recruits who met entrance standards (men: adjusted OR = 13.3 [95% CI: 10.3, 17.2]; women: adjusted OR = 3.6 [3.3, 3.9]). Although the discharge frequency was higher in the waiver group than in those who met standards (25.4% versus 19.9%, p < 0.001), there were only 10 (0.5% of total) discharges directly attributed to weight. Granting overweight waivers through the ARMS program increases enrollment to the AWCP but has little effect on weight-related attrition.
C1 [Bedno, Sheryl A.; Datu, Bennett; Niebuhr, David W.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA.
[Lang, Christine E.; Wiesen, Andrew R.] Madigan Army Med Ctr, ATTN MCHJ PV, Tacoma, WA 98431 USA.
[Daniell, William E.] Univ Washington, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA.
RP Bedno, SA (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Rd, Silver Spring, MD 20910 USA.
FU U.S. Army Accession Command
FX This study was funded by the U.S. Army Accession Command.
NR 14
TC 8
Z9 8
U1 1
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2010
VL 175
IS 3
BP 188
EP 193
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 582GT
UT WOS:000276585400012
PM 20358709
ER
PT J
AU Magee, CD
Moawad, FJ
Moses, F
AF Magee, Charles D.
Moawad, Fouad J.
Moses, Frank
TI NO-Xplode: A Case of Supplement-Associated Ischemic Colitis
SO MILITARY MEDICINE
LA English
DT Article
ID NITRIC-OXIDE; L-ARGININE; EXERCISE; HUMANS; RUNNERS
AB The most common cause of ischemic colitis (IC) is a sudden and transient reduction in splanchnic perfusion. In the younger population, medications are an increasingly recognized cause of ischemic bowel disease. Over-the-counter supplements may also lead to the development of ischemic colitis through similar effects. We present a case of ischemic colitis in a 42-year-old active duty service member after using the performance-enhancing supplement, NO-Xplode. In this report, we review the pharmacology of this supplement and its proposed mechanism of injury.
C1 [Magee, Charles D.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA.
[Moawad, Fouad J.; Moses, Frank] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA.
RP Magee, CD (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave, Washington, DC 20307 USA.
NR 20
TC 7
Z9 7
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2010
VL 175
IS 3
BP 202
EP 205
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 582GT
UT WOS:000276585400015
PM 20358712
ER
PT J
AU Alosh, M
AF Alosh, Mahdi
TI Advanced Media Arabic
SO MODERN LANGUAGE JOURNAL
LA English
DT Book Review
C1 [Alosh, Mahdi] US Mil Acad, West Point, NY 10996 USA.
RP Alosh, M (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0026-7902
J9 MOD LANG J
JI Mod. Lang. J.
PD SPR
PY 2010
VL 94
IS 1
BP 159
EP 160
PG 2
WC Education & Educational Research; Linguistics
SC Education & Educational Research; Linguistics
GA 552AY
UT WOS:000274258900019
ER
PT J
AU Sherman, LS
Blum, JD
Johnson, KP
Keeler, GJ
Barres, JA
Douglas, TA
AF Sherman, Laura S.
Blum, Joel D.
Johnson, Kelsey P.
Keeler, Gerald J.
Barres, James A.
Douglas, Thomas A.
TI Mass-independent fractionation of mercury isotopes in Arctic snow driven
by sunlight
SO NATURE GEOSCIENCE
LA English
DT Article
ID HEAVY-ELEMENTS; CANADA; REDUCTION; ALERT; SPRINGTIME; DEPOSITION;
CHEMISTRY; SNOWPACKS; SYSTEMS; HG(II)
AB After polar sunrise in the Arctic, sunlight-induced reactions convert gaseous elemental mercury into compounds that are rapidly deposited to the snowpack. These atmospheric mercury depletion events occur repeatedly until snowmelt(1,2). Following deposition, the mercury can be reduced by sunlight-induced reactions and emitted as a gas(3-6), or can be retained in the snowpack(7,8), where it may affect Arctic ecosystems following snowmelt. However, the proportion of mercury that remains in the snowpack is uncertain. Here, we measured the mercury isotopic composition of snow samples collected during an atmospheric mercury depletion event in Barrow, Alaska. We report large negative mass-independent fractionation of mercury isotopes in the Arctic snow. Results from a flux chamber experiment suggest that mass-independent fractionation is coupled to the re-emission of elemental mercury to the atmosphere, and is triggered by sunlight-induced reactions. On the basis of the above, we estimate that photochemical reactions triggered the release of a significant portion of the mercury deposited during this atmospheric mercury depletion event.
C1 [Sherman, Laura S.; Blum, Joel D.; Johnson, Kelsey P.] Univ Michigan, Dept Geol Sci, Ann Arbor, MI 48109 USA.
[Keeler, Gerald J.; Barres, James A.] Univ Michigan, Air Qual Lab, Ann Arbor, MI 48109 USA.
[Douglas, Thomas A.] Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA.
RP Sherman, LS (reprint author), Univ Michigan, Dept Geol Sci, 1100 N Univ Ave, Ann Arbor, MI 48109 USA.
EM lsaylors@umich.edu
FU National Science Foundation Office of Polar Programs [ARC-0435989,
ARC-0435893]; National Defense Science and Engineering Graduate
Fellowship through the Department of Defense, Office of Naval Research
FX Financial support for this research was provided by the National Science
Foundation Office of Polar Programs (Grants ARC-0435989 and
ARC-0435893). L. S. S. is financially supported by a National Defense
Science and Engineering Graduate Fellowship through the Department of
Defense, Office of Naval Research. We are grateful to M. W. Johnson, L.
Alvarez-Aviles, M. Sturm, R. Prevost, P. W. Sherman and the members of
BEIGL for assistance and helpful discussions.
NR 30
TC 98
Z9 105
U1 7
U2 53
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1752-0894
J9 NAT GEOSCI
JI Nat. Geosci.
PD MAR
PY 2010
VL 3
IS 3
BP 173
EP 177
DI 10.1038/NGEO758
PG 5
WC Geosciences, Multidisciplinary
SC Geology
GA 561KF
UT WOS:000274974700017
ER
PT J
AU Satirapoj, B
Supasyndh, O
Chaiprasert, A
Ruangkanchanasetr, P
Kanjanakul, I
Phulsuksombuti, D
Utainam, D
Choovichian, P
AF Satirapoj, Bancha
Supasyndh, Ouppatham
Chaiprasert, Amnart
Ruangkanchanasetr, Prajej
Kanjanakul, Inseey
Phulsuksombuti, Duangporn
Utainam, Darunee
Choovichian, Panbuppa
TI Relationship between serum uric acid levels with chronic kidney disease
in a Southeast Asian population
SO NEPHROLOGY
LA English
DT Article
DE chronic kidney disease; glomerular filtration rate; hyperuricaemia
ID RENAL-DISEASE; RISK-FACTORS; PROGRESSION; HYPERURICEMIA; GOUT;
PREDICTORS; COHORT; RATS
AB Aim: Elevated serum uric level has been suggested as a risk factor for chronic kidney disease (CKD). The relationship between serum uric acid level, and CKD in a Southeast Asian population was examined.
Methods: In a cross-sectional study, authors surveyed 5618 subjects, but 5546 participants were included. The glomerular filtration rate (GFR) values were calculated by the Modification of Diet in Renal Disease (MDRD) equation. CKD was defined as a GFR of less than 60 mL/min per 1.73 m(2). Multivariate binary logistic regression was used to determine the association between serum uric acid level and CKD.
Results: The prevalence of CKD in serum uric acid quartiles: first quartile, 5.3 mg/dL or less; second quartile, 5.4-6.4 mg/dL; third quartile, 6.5-7.6 mg/dL; and fourth quartile, 7.7 mg/dL or more were 1.8%, 3.6%, 5.5% and 11.9%, respectively (P < 0.001). The mean values of estimated GFR in participants with CKD and without CKD were 53.44 +/- 7.72 and 81.26 +/- 12.48 mL/min per 1.73 m(2) respectively. In the entire participants, there were 6.76% with hypertension and 2.64% with diabetes as a comorbid disease. Compared with serum uric acid first quartile, the multivariate-adjusted odds for CKD of the fourth, third and second quartile were 10.94 (95% confidence interval (CI), 6.62-16.08), 4.17 (95% CI, 2.51-6.92) and 2.38 (95% CI, 1.43-3.95), respectively.
Conclusion: High serum uric acid level was independently associated with increased prevalence of CKD in the Southeast Asian population. Detection and treatment of hyperuricaemia should be attended as a strategy to prevent CKD.
C1 [Satirapoj, Bancha; Supasyndh, Ouppatham; Chaiprasert, Amnart; Ruangkanchanasetr, Prajej; Kanjanakul, Inseey; Choovichian, Panbuppa] Phramongkutklao Hosp, Dept Med, Div Nephrol, Bangkok 10400, Thailand.
[Satirapoj, Bancha; Supasyndh, Ouppatham; Chaiprasert, Amnart; Ruangkanchanasetr, Prajej; Kanjanakul, Inseey; Choovichian, Panbuppa] Coll Med, Bangkok, Thailand.
[Phulsuksombuti, Duangporn; Utainam, Darunee] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
RP Satirapoj, B (reprint author), Phramongkutklao Hosp, Dept Med, Div Nephrol, Bangkok 10400, Thailand.
EM satirapoj@yahoo.com
FU Department of Medicine, Phramongkutklao Hospital
FX The authors wish to acknowledge Sharon Adler, MD, for helpful
suggestions and Miss Dollapas Punpanich for statistical analysis. This
study was supported by a grant from the Department of Medicine,
Phramongkutklao Hospital.
NR 19
TC 11
Z9 15
U1 1
U2 3
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1320-5358
J9 NEPHROLOGY
JI Nephrology
PD MAR
PY 2010
VL 15
IS 2
BP 253
EP 258
DI 10.1111/j.1440-1797.2009.01179.x
PG 6
WC Urology & Nephrology
SC Urology & Nephrology
GA 564IQ
UT WOS:000275206900019
PM 20470288
ER
PT J
AU Loh, Y
Swanberg, MM
Ingram, MV
Newmark, J
AF Loh, Yince
Swanberg, Margaret M.
Ingram, M. Victoria
Newmark, Jonathan
TI Case report: Long-term cognitive sequelae of sarin exposure
SO NEUROTOXICOLOGY
LA English
DT Article
DE Sarin; Neurocognition; Neuropsychological; Organophosphate; Weaponized
ID US ARMY VETERANS; 1991 GULF-WAR; BRAIN; RATS; CYCLOSARIN; INHALATION;
MARMOSET; MONKEYS
AB The long-term sequelae of acute satin exposure are not well understood. The largest clinical cohort resulted from the 1994 and 1995 attacks in Japan. Observers noted mostly psychiatric sequelae, with a high prevalence of post-traumatic stress disorder (PTSD). We describe neurocognitive findings that may represent sequelae of low-level sarin exposure in Iraq. Published by Elsevier Inc.
C1 [Loh, Yince] Madigan Army Med Ctr, Neurol Sect, Dept Med, Tacoma, WA 98431 USA.
[Swanberg, Margaret M.] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA.
[Ingram, M. Victoria] Womack Army Med Ctr, Psychol Serv, Ft Bragg, NC 28310 USA.
[Newmark, Jonathan] USA, Med Res Inst Chem Def, Chem Casualty Care Div, Aberdeen Proving Ground, MD 21010 USA.
RP Loh, Y (reprint author), Madigan Army Med Ctr, Neurol Sect, Dept Med, Bldg 9040,Fitzsimmons Dr, Tacoma, WA 98431 USA.
EM yincer@yahoo.com
NR 17
TC 7
Z9 7
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0161-813X
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD MAR
PY 2010
VL 31
IS 2
BP 244
EP 246
DI 10.1016/j.neuro.2009.12.004
PG 3
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA 574KF
UT WOS:000275987300010
PM 20036279
ER
PT J
AU Leinweber, G
Barry, DP
Burke, JA
Drindak, NJ
Danon, Y
Block, RC
Francis, NC
Moretti, BE
AF Leinweber, G.
Barry, D. P.
Burke, J. A.
Drindak, N. J.
Danon, Y.
Block, R. C.
Francis, N. C.
Moretti, B. E.
TI Resonance Parameters and Uncertainties Derived from Epithermal Neutron
Capture and Transmission Measurements of Natural Molybdenum
SO NUCLEAR SCIENCE AND ENGINEERING
LA English
DT Article
ID RADIATIVE CAPTURE
AB The electron linear accelerator facility at the Rensselaer Polytechnic Institute was used to explore neutron interactions with molybdenum in the energy region from 10 eV to 2 keV. Neutron capture and transmission measurements were performed by the time-of-flight technique. Resonance parameters were extracted from the data using the multilevel R-matrix Bayesian code SAMMY. A table of resonance parameters and their uncertainties is presented. Two transmission measurements were performed at a flight path of 25 in with a (6)Li glass scintillation detector. The neutron capture measurements were performed at a flight path of 25 m with a 16-segment sodium iodide multiplicity detector. Nine different thicknesses of elemental molybdenum metal samples ranging from 0.051 mm (0.002 in.) to 6.35 mm (0.250 in.) were measured in either capture or transmission. Reductions in resonance integrals were observed when compared to ENDF/B-VII.0 for six of the seven stable isotopes. The largest reductions were 9% in (97)Mo and 11% in (100)Mo. The one measured increase in resonance integral relative to ENDF/B-VII.0 occurred in (95)Mo, and it was significant (10%). The measured distribution of neutron widths for (95)Mo and (97)Mo are a better match to a Porter-Thomas distribution than those of ENDF/B-VII.0. Neutron strength functions for (95)Mo and (97)Mo were measured and compared to ENDF/B-VII.0. The strength of (95)Mo and (97)Mo are within uncertainties of each other. The measured radiation width distribution for (95)Mo and (97)Mo are compared to those of ENDF/B-VII.0 and to chi(2) distributions. Significant aspects of this analysis are the assignment of radiation widths, the determination of the transmission resolution function, and the propagation of experimental uncertainties into resonance parameter uncertainties.
C1 [Leinweber, G.; Barry, D. P.; Burke, J. A.; Drindak, N. J.] Bechtel Marine Prop Corp, Knolls Atom Power Lab, Schenectady, NY 12301 USA.
[Danon, Y.; Block, R. C.; Francis, N. C.] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA.
[Moretti, B. E.] US Mil Acad, Dept Phys, West Point, NY 10996 USA.
RP Leinweber, G (reprint author), Bechtel Marine Prop Corp, Knolls Atom Power Lab, POB 1072, Schenectady, NY 12301 USA.
EM leinwg@rpi.edu
NR 22
TC 8
Z9 8
U1 0
U2 2
PU AMER NUCLEAR SOC
PI LA GRANGE PK
PA 555 N KENSINGTON AVE, LA GRANGE PK, IL 60526 USA
SN 0029-5639
J9 NUCL SCI ENG
JI Nucl. Sci. Eng.
PD MAR
PY 2010
VL 164
IS 3
BP 287
EP 303
PG 17
WC Nuclear Science & Technology
SC Nuclear Science & Technology
GA 600US
UT WOS:000278015000005
ER
PT J
AU Fernandes, GE
Kim, JH
Liu, ZJ
Shainline, J
Osgood, R
Xu, J
AF Fernandes, Gustavo E.
Kim, Jin Ho
Liu, Zhijun
Shainline, Jeffrey
Osgood, Richard, III
Xu, Jimmy
TI Using a forest of gold nanowires to reduce the reflectivity of silicon
SO OPTICAL MATERIALS
LA English
DT Article
DE Metamaterials; Energy harvesting; Silicon photovoltaics; Porous alumina;
Anti-reflection coatings; Optical filters
ID INFRARED-ABSORPTION; FABRICATION; SURFACE; SIZE
AB The optical reflectivity of polished silicon covered by a forest of vertically standing gold nanowires (grown inside the pores of an anodic alumina matrix) is found to be considerably smaller than that of bare polished silicon and strongly influenced by scattering of light by the nanowires. We propose a phenomenological modification to the Maxwell-Garnett effective medium theory formula to account for this effect. We also find that the gold nanowire/alumina film has interesting optical properties, such as transparency in the mid-infrared and high absorbance in the visible, and may be used as a low reflectivity coating and a low-pass filter. (c) 2010 Elsevier B.V. All rights reserved.
C1 [Fernandes, Gustavo E.; Kim, Jin Ho; Liu, Zhijun; Xu, Jimmy] Brown Univ, Div Engn, Providence, RI 02912 USA.
[Shainline, Jeffrey; Xu, Jimmy] Brown Univ, Dept Phys, Providence, RI 02912 USA.
[Osgood, Richard, III] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Fernandes, GE (reprint author), Brown Univ, Div Engn, Box D, Providence, RI 02912 USA.
EM Gustavo_Fernandes@Brown.edu
FU AFOSR; ARO; Seoul National University
FX This work was supported in part by AFOSR, ARO, and by the WCU program of
Seoul National University.
NR 19
TC 7
Z9 7
U1 1
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-3467
J9 OPT MATER
JI Opt. Mater.
PD MAR
PY 2010
VL 32
IS 5
BP 623
EP 626
DI 10.1016/j.optmat.2009.12.010
PG 4
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA 569OA
UT WOS:000275605600011
ER
PT J
AU Roppo, V
Wang, W
Kalinowski, K
Kong, Y
Cojocaru, C
Trull, J
Vilaseca, R
Scalora, M
Krolikowski, W
Kivshar, Y
AF Roppo, V.
Wang, W.
Kalinowski, K.
Kong, Y.
Cojocaru, C.
Trull, J.
Vilaseca, R.
Scalora, M.
Krolikowski, W.
Kivshar, Yu.
TI The role of ferroelectric domain structure in second harmonic generation
in random quadratic media
SO OPTICS EXPRESS
LA English
DT Article
ID STRONTIUM-BARIUM NIOBATE; HARMONIC-GENERATION; 3RD-HARMONIC GENERATION;
NONLINEAR CRYSTALS; FORCE MICROSCOPE; SINGLE-CRYSTALS; LASER CRYSTAL;
SCATTERING; LIGHT; SR0.61BA0.39NB2O6
AB We study theoretically and numerically the second harmonic generation in a nonlinear crystal with random distribution of ferroelectric domains. We show that the specific features of disordered domain structure greatly affect the emission pattern of the generated harmonics. This phenomena can be used to characterize the degree of disorder in nonlinear photonic structures. (C) 2010 Optical Society of America
C1 [Roppo, V.; Cojocaru, C.; Trull, J.; Vilaseca, R.] Univ Politecn Cataluna, Dept Fis & Engn Nucl, ETSEIAT, Barcelona 08222, Spain.
[Roppo, V.; Wang, W.; Kalinowski, K.; Krolikowski, W.; Kivshar, Yu.] Australian Natl Univ, Nonlinear Phys Ctr, Canberra, ACT 0200, Australia.
[Roppo, V.; Wang, W.; Kalinowski, K.; Krolikowski, W.; Kivshar, Yu.] Australian Natl Univ, Res Sch Phys & Engn, Laser Phys Ctr, Canberra, ACT 0200, Australia.
[Wang, W.; Kong, Y.] Nankai Univ, Coll Phys Sci, Tianjin 300071, Peoples R China.
[Scalora, M.] USA, Charles M Bowden Res Facil, RDECOM, Aviat & Missile Command, Redstone Arsenal, AL 35803 USA.
RP Roppo, V (reprint author), Univ Politecn Cataluna, Dept Fis & Engn Nucl, ETSEIAT, Colom 11, Barcelona 08222, Spain.
RI Kong, Yongfa/A-1238-2009; Krolikowski, wieslaw/A-7083-2011; roppo,
vito/D-9639-2012; Trull, Jose/L-9054-2014;
OI roppo, vito/0000-0003-0928-4209; Trull, Jose/0000-0002-5850-088X;
Vilaseca, Ramon/0000-0002-3736-5789
FU Australian Research Council; Spanish Government [FIS2008-06024-C03-02];
Catalan Government [2009 SGR 1168, BE 2009]; COST Action [MP0702]
FX This work was supported by the Australian Research Council, Spanish
Government (FIS2008-06024-C03-02), Catalan Government (2009 SGR 1168 and
BE 2009) and the COST Action MP0702. V. R. thanks Cristian Ciraci for
helpful discussions and suggestions with the images. The authors thank
D. Neshev for collaboration.
NR 36
TC 10
Z9 10
U1 0
U2 6
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD MAR 1
PY 2010
VL 18
IS 5
BP 4012
EP 4022
DI 10.1364/OE.18.004012
PG 11
WC Optics
SC Optics
GA 567NO
UT WOS:000275454100080
PM 20389416
ER
PT J
AU Kantanen, DJ
Closmann, JJ
Rowshan, HH
AF Kantanen, Dennis J.
Closmann, James J.
Rowshan, Henry H.
TI Abdominal fat harvest technique and its uses in maxillofacial surgery
SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND
ENDODONTOLOGY
LA English
DT Article
ID GRAFT
AB Abdominal fat harvest and augmentation to the maxillofacial region is a relatively inexpensive, safe, and readily available procedure. The use of abdominal fat free transfer has been well documented for cosmetic, trauma, and temporomandibular joint reconstruction. Fat is the closest we have to an ideal filler, it is readily available and inexpensive, it is autologous and therefore lacks a host immune response, it is safe and noncarcinogenic, and it is easily acquired with a minimally invasive procedure. Abdominal fat donor site is the most commonly used owing to ease of access and availability of fat stores. Complications are rare and easily managed in the office. Free abdominal fat harvest is a predictable surgical technique that allows the maxillofacial surgeon access to autologous graft material that is ideal for multiple facial procedures. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 367-371)
C1 [Kantanen, Dennis J.; Closmann, James J.; Rowshan, Henry H.] Tripler Army Med Ctr, Div Oral & Maxillofacial Surg, Honolulu, HI 96859 USA.
RP Kantanen, DJ (reprint author), Tripler Army Med Ctr, Div Oral & Maxillofacial Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM dkantanen@hotmail.com
NR 15
TC 9
Z9 9
U1 1
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1079-2104
J9 ORAL SURG ORAL MED O
JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
PD MAR
PY 2010
VL 109
IS 3
BP 367
EP 371
DI 10.1016/j.tripleo.2009.09.037
PG 5
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 561DT
UT WOS:000274956600009
PM 20060341
ER
PT J
AU Robitschek, J
Straub, M
Wirtz, E
Klem, C
Sniezek, J
AF Robitschek, Jon
Straub, Mary
Wirtz, Eric
Klem, Christopher
Sniezek, Joseph
TI Diagnostic efficacy of surgeon-performed ultrasound-guided fine needle
aspiration: A randomized controlled trial
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article
ID BIOPSY; MASSES; HEAD
AB OBJECTIVE: To evaluate the clinical efficacy of surgeon-performed, office-based head and neck ultrasound in facilitating diagnostic fine needle aspiration (FNA) of lesions in the head and neck.
STUDY DESIGN: A randomized controlled trial of ultrasound-guided FNA versus traditional palpation-guided technique for palpable masses in the head and neck.
SETTING: An office-based study performed in a military academic medical center.
SUBJECTS AND METHODS: Eighty-one adults older than 18 years of age with a palpable head and neck mass (less than 3 cm in largest diameter) were randomized to ultrasound-guided or traditional palpation-guided FNA of a head and neck mass. Measured variables and outcomes for the study included tissue adequacy rates, tissue type, and operator variability.
RESULTS: Following three passes using either palpation or ultrasound guidance, a comparative tissue adequacy rate of 84 percent for ultrasound guidance versus 58 percent for standard palpation was established (P < 0.014). With regard to tissue type, a statistically significant comparative diagnostic advantage for ultrasound guidance was observed in thyroid tissue while remaining statistically insignificant for lymphatic and salivary tissues. No statistical significance was found when comparing the ability of otolaryngology residents versus attending otolaryngologists to obtain ultrasound-guided diagnostic samples.
CONCLUSION: Office-based surgeon-performed ultrasound-guided FNA of palpable lesions in the head and neck yields a statistically significant higher diagnostic rate compared to standard palpation technique. Our institutional experience supports the utility of surgeon-performed ultrasound as a core competency in clinical practice. (c) 2010 American Academy of Otolaryngology Head and Neck Surgery Foundation. All rights reserved.
C1 [Robitschek, Jon; Straub, Mary; Wirtz, Eric; Klem, Christopher; Sniezek, Joseph] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA.
RP Wirtz, E (reprint author), 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM eric.d.wirtz@us.army.mil
FU AMEDD Advanced Medical Technology Initiative Grant
FX This study was supported by the AMEDD Advanced Medical Technology
Initiative Grant (funding helped to provide equipment for collection of
data).
NR 7
TC 17
Z9 19
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD MAR
PY 2010
VL 142
IS 3
BP 306
EP 309
DI 10.1016/j.otohns.2009.11.011
PG 4
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA 582DA
UT WOS:000276574600002
PM 20172371
ER
PT J
AU Eckart, RE
Gentlesk, PJ
Shry, EA
AF Eckart, Robert E.
Gentlesk, Philip J.
Shry, Eric A.
TI Differential Manifestation of Cardiovascular Complaints as a Function of
Utilization of Ergogenic Supplements
SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
LA English
DT Article
DE supplement use; syncope; palpitations
ID ALTERNATIVE MEDICINE; DIAGNOSING SYNCOPE; DIETARY-SUPPLEMENT; YOUNG
AB Introduction: The rate of use of dietary supplements among young adults is significant. While the military makes significant restrictions on the use of certain pharmacologic drugs and actively tests for illegal drugs in a deployed environment, there is a near-unlimited supply of body-enhancing supplements available at military exchanges to deployed personnel. By emphasizing physical performance and providing these for purchase, the military leadership, perhaps unknowingly, endorses the use of these products. Cardiovascular symptoms represent one of the leading nontraumatic causes of aeromedical evacuation from a combat zone. Whether the use of supplements is associated with a differential presentation to cardiovascular complaint is unknown.
Methods: Retrospective review using the US Department of Defense Military Health System data, we identified patients evaluated for cardiovascular complaints of syncope or palpitations while deployed to Iraq and Afghanistan.
Results: There were 905 US military personnel who presented with complaint of syncope or palpitations (mean age 31 +/- 10 years, 77% male). There were 83 (9.2%) who self-reported taking an ergogenic supplement. The incidence of reported use of supplements among males was 10.8%, which was significantly higher than its use among females at 3.8% (P = 0.001). In those > 30 years, those on supplements had a higher resting pulse (90 +/- 28 vs 79 +/- 24 beats/min, P = 0.032), and the incidence of resting tachycardia was three-fold higher (35.0% vs 11.4%, P = 0.008). Supplement use was seen in 12.3% of those who presented with palpitations, which was significantly higher than those who presented without palpitations (7.8%, P = 0.043). In those taking supplements, symptoms were more likely during exertion (26.5% vs 15.0%, P < 0.001), and immediately postexertional (13.2% vs 4.6%, P < 0.001). An electrocardiogram was suggestive of diagnosis in 103 (16.3%), while head computed tomography, treadmill, and echocardiogram had no diagnostic utility in this patient population.
Discussion: In a healthy population serving within a combat zone, there exists a differential expression of disease in those taking supplements. Further study of a prospective nature to determine the impact of supplement use in this environment may allow for a more refined policy toward use and medical evaluation. (PACE 2010; 33:286-289)
C1 [Eckart, Robert E.; Gentlesk, Philip J.] San Antonio Mil Med Ctr, San Antonio, TX USA.
[Shry, Eric A.] Landstuhl Reg Med Ctr, Landstuhl, Germany.
RP Eckart, RE (reprint author), Brooke Army Med Ctr, Arrhythmia Serv Cardiol MCHE MDC, Ft Sam Houston, TX 78234 USA.
EM robert.eckart@us.army.mil
NR 27
TC 4
Z9 4
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0147-8389
J9 PACE
JI PACE-Pacing Clin. Electrophysiol.
PD MAR
PY 2010
VL 33
IS 3
BP 286
EP 289
DI 10.1111/j.1540-8159.2009.02610.x
PG 4
WC Cardiac & Cardiovascular Systems; Engineering, Biomedical
SC Cardiovascular System & Cardiology; Engineering
GA 563DK
UT WOS:000275107500007
PM 20015135
ER
PT J
AU Perez, C
AF Perez, Celestino
TI Killing in War
SO PERSPECTIVES ON POLITICS
LA English
DT Book Review
C1 [Perez, Celestino] USA, Command & Gen Staff Coll, Washington, DC 20310 USA.
RP Perez, C (reprint author), USA, Command & Gen Staff Coll, Washington, DC 20310 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1537-5927
J9 PERSPECT POLIT
JI Perspect. Polit.
PD MAR
PY 2010
VL 8
IS 1
BP 340
EP 343
PG 5
WC Political Science
SC Government & Law
GA 584CP
UT WOS:000276727900064
ER
PT J
AU Perez, C
AF Perez, Celestino
TI How Do I Save My Honor? War, Moral Integrity, and Principled Resignation
SO PERSPECTIVES ON POLITICS
LA English
DT Book Review
C1 [Perez, Celestino] USA, Command & Gen Staff Coll, Washington, DC 20310 USA.
RP Perez, C (reprint author), USA, Command & Gen Staff Coll, Washington, DC 20310 USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1537-5927
J9 PERSPECT POLIT
JI Perspect. Polit.
PD MAR
PY 2010
VL 8
IS 1
BP 340
EP 343
PG 5
WC Political Science
SC Government & Law
GA 584CP
UT WOS:000276727900063
ER
PT J
AU Foreman, JV
Everitt, HO
Yang, J
McNicholas, T
Liu, J
AF Foreman, J. V.
Everitt, H. O.
Yang, J.
McNicholas, T.
Liu, J.
TI Effects of reabsorption and spatial trap distributions on the radiative
quantum efficiencies of ZnO
SO PHYSICAL REVIEW B
LA English
DT Article
ID ZINC-OXIDE; ABSORPTION; PHOSPHORS; CRYSTALS; SPECTRA; ENERGY
AB Ultrafast time-resolved photoluminescence spectroscopy following one- and two-photon excitations of ZnO powder is used to gain unprecedented insight into the surprisingly high external quantum efficiency of its "green" defect emission band. The role of exciton diffusion, the effects of reabsorption, and the spatial distributions of radiative and nonradiative traps are comparatively elucidated for the ultraviolet excitonic and "green" defect emission bands in both unannealed nanometer-sized ZnO powders and annealed micrometer-sized ZnO:Zn powders. We find that the primary mechanism limiting quantum efficiency is surface recombination because of the high density of nonradiative surface traps in these powders. It is found that unannealed ZnO has a high density of bulk nonradiative traps as well, but the annealing process reduces the density of these bulk traps while simultaneously creating a high density of green-emitting defects near the particle surface. The data are discussed in the context of a simple rate equation model that accounts for the quantum efficiencies of both emission bands. The results indicate how defect engineering could improve the efficiency of ultraviolet-excited ZnO:Zn-based white light phosphors.
C1 [Foreman, J. V.] Duke Univ, Dept Phys, Durham, NC 27708 USA.
US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA.
[Yang, J.; McNicholas, T.; Liu, J.] Duke Univ, Dept Chem, Durham, NC 27708 USA.
RP Foreman, JV (reprint author), Duke Univ, Dept Phys, Durham, NC 27708 USA.
EM john.v.foreman@us.army.mil
RI Everitt, Henry/L-7118-2013
OI Everitt, Henry/0000-0002-8141-3768
FU RDECOM/AMRDEC Competitive In-House Laboratory Independent Research
(ILIR)
FX This work was supported by RDECOM/AMRDEC Competitive In-House Laboratory
Independent Research (ILIR) funding. J. V. F. and H. O. E. thank U.
Ozgur for a critical reading of an early version of this manuscript.
NR 30
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U1 0
U2 15
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1098-0121
J9 PHYS REV B
JI Phys. Rev. B
PD MAR
PY 2010
VL 81
IS 11
AR 115318
DI 10.1103/PhysRevB.81.115318
PG 10
WC Physics, Condensed Matter
SC Physics
GA 577UF
UT WOS:000276248800095
ER
PT J
AU Ignaccolo, M
Latka, M
Jernajczyk, W
Grigolini, P
West, BJ
AF Ignaccolo, M.
Latka, M.
Jernajczyk, W.
Grigolini, P.
West, B. J.
TI Dynamics of electroencephalogram entropy and pitfalls of scaling
detection
SO PHYSICAL REVIEW E
LA English
DT Article
ID TEEN BIRTH PHENOMENON; FLUCTUATION ANALYSIS; TIME-SERIES; BEHAVIOR; EEG
AB In recent studies a number of research groups have determined that human electroencephalograms (EEG) have scaling properties. In particular, a crossover between two regions with different scaling exponents has been reported. Herein we study the time evolution of diffusion entropy to elucidate the scaling of EEG time series. For a cohort of 20 awake healthy volunteers with closed eyes, we find that the diffusion entropy of EEG increments (obtained from EEG waveforms by differencing) exhibits three features: short-time growth, an alpha wave related oscillation whose amplitude gradually decays in time, and asymptotic saturation which is achieved after approximately 1 s. This analysis suggests a linear, stochastic Ornstein-Uhlenbeck Langevin equation with a quasiperiodic forcing (whose frequency and/or amplitude may vary in time) as the model for the underlying dynamics. This model captures the salient properties of EEG dynamics. In particular, both the experimental and simulated EEG time series exhibit short-time scaling which is broken by a strong periodic component, such as alpha waves. The saturation of EEG diffusion entropy precludes the existence of asymptotic scaling. We find that the crossover between two scaling regions seen in detrended fluctuation analysis (DFA) of EEG increments does not originate from the underlying dynamics but is merely an artifact of the algorithm. This artifact is rooted in the failure of the "trend plus signal" paradigm of DFA.
C1 [Ignaccolo, M.; West, B. J.] Duke Univ, Dept Phys, Durham, NC 27709 USA.
[Latka, M.] Wroclaw Univ Technol, Inst Biomed Engn, PL-50370 Wroclaw, Poland.
[Jernajczyk, W.] Inst Psychiat & Neurol, Dept Clin Neurophysiol, Warsaw, Poland.
[Grigolini, P.] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA.
[West, B. J.] USA, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA.
RP Ignaccolo, M (reprint author), Duke Univ, Dept Phys, Durham, NC 27709 USA.
FU Army Research Office
FX M. I. and P. G. thank the Army Research Office for support of this
research. The code of the programs used for the EEG analysis (DE and
spectrogram) can be downloaded following this link [27]. The code used
for the DFA analysis is the one available at PhysioNet website [8]. We
thank Andrzej Latka for his comments on the manuscript.
NR 26
TC 9
Z9 9
U1 2
U2 7
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1539-3755
J9 PHYS REV E
JI Phys. Rev. E
PD MAR
PY 2010
VL 81
IS 3
AR 031909
DI 10.1103/PhysRevE.81.031909
PN 1
PG 9
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA 577CT
UT WOS:000276199300092
PM 20365772
ER
PT J
AU Aronson, NE
Wortmann, GW
Byrne, WR
Howard, RS
Bernstein, WB
Marovich, MA
Polhemus, ME
Yoon, IK
Hummer, KA
Gasser, RA
Oster, CN
Benson, PM
AF Aronson, Naomi E.
Wortmann, Glenn W.
Byrne, William R.
Howard, Robin S.
Bernstein, Wendy B.
Marovich, Mary A.
Polhemus, Mark E.
Yoon, In-Kyu
Hummer, Kelly A.
Gasser, Robert A., Jr.
Oster, Charles N.
Benson, Paul M.
TI A Randomized Controlled Trial of Local Heat Therapy Versus Intravenous
Sodium Stibogluconate for the Treatment of Cutaneous Leishmania major
Infection
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID MACROPHAGES INVITRO; COST-EFFECTIVENESS; EFFICACY; THERMOTHERAPY;
AFGHANISTAN; GLUCANTIME; PARASITES; KABUL
AB Background: Cutaneous Leishmania major has affected many travelers including military personnel in Iraq and Afghanistan. Optimal treatment for this localized infection has not been defined, but interestingly the parasite is thermosensitive.
Methodology/Principal Findings: Participants with parasitologically confirmed L. major infection were randomized to receive intravenous sodium stibogluconate (SSG) 20mg/kg/day for ten doses or localized ThermoMed (TM) device heat treatment (applied at 50 degrees C for 30 seconds) in one session. Those with facial lesions, infection with other species of Leishmania, or more than 20 lesions were excluded. Primary outcome was complete re-epithelialization or visual healing at two months without relapse over 12 months. Fifty-four/56 enrolled participants received intervention, 27 SSG and 27 TM. In an intent to treat analysis the per subject efficacy at two months with 12 months follow-up was 54% SSG and 48% TM (p = 0.78), and the per lesion efficacy was 59% SSG and 73% TM (p = 0.053). Reversible abdominal pain/pancreatitis, arthralgias, myalgias, headache, fatigue, mild cytopenias, and elevated transaminases were more commonly present in the SSG treated participants, whereas blistering, oozing, and erythema were more common in the TM arm.
Conclusions/Significance: Skin lesions due to L. major treated with heat delivered by the ThermoMed device healed at a similar rate and with less associated systemic toxicity than lesions treated with intravenous SSG.
C1 [Aronson, Naomi E.; Wortmann, Glenn W.; Bernstein, Wendy B.; Marovich, Mary A.; Polhemus, Mark E.; Gasser, Robert A., Jr.; Oster, Charles N.] Uniformed Serv Univ Hlth Sci, Div Infect Dis, Bethesda, MD 20814 USA.
[Aronson, Naomi E.; Wortmann, Glenn W.; Byrne, William R.; Polhemus, Mark E.; Hummer, Kelly A.; Gasser, Robert A., Jr.; Oster, Charles N.; Benson, Paul M.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA.
[Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA.
[Bernstein, Wendy B.; Marovich, Mary A.] Walter Reed Army Inst Res, Dept Retroviral, Rockville, MD USA.
[Yoon, In-Kyu] Walter Reed Army Inst Res, Dept Clin Trials, Silver Spring, MD USA.
[Hummer, Kelly A.] Clin Res Management, Hinckley, OH USA.
RP Aronson, NE (reprint author), Uniformed Serv Univ Hlth Sci, Div Infect Dis, Bethesda, MD 20814 USA.
EM Naomi.aronson@us.army.mil
FU Walter Reed Army Medical Center; North Atlantic Regional Medical
Command; US Army Medical and Materiel Development Agency; US Army
Medical Materiel and Development Agency
FX This trial was supported by Walter Reed Army Medical Center, The North
Atlantic Regional Medical Command, and the US Army Medical and Materiel
Development Agency. The study sponsor (US Army Medical Materiel and
Development Agency) reviewed the study protocol during development,
provided the study drug (SSG) and trial monitoring, and approved this
manuscript.
NR 27
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U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAR
PY 2010
VL 4
IS 3
AR e628
DI 10.1371/journal.pntd.0000628
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 578RG
UT WOS:000276312200026
PM 20231896
ER
PT J
AU Fried, JR
Gibbons, RV
Kalayanarooj, S
Thomas, SJ
Srikiatkhachorn, A
Yoon, IK
Jarman, RG
Green, S
Rothman, AL
Cummings, DAT
AF Fried, Jessica R.
Gibbons, Robert V.
Kalayanarooj, Siripen
Thomas, Stephen J.
Srikiatkhachorn, Anon
Yoon, In-Kyu
Jarman, Richard G.
Green, Sharone
Rothman, Alan L.
Cummings, Derek A. T.
TI Serotype-Specific Differences in the Risk of Dengue Hemorrhagic Fever:
An Analysis of Data Collected in Bangkok, Thailand from 1994 to 2006
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID DISEASE SEVERITY; VIRUS-INFECTION; SHOCK SYNDROME; HLA-B;
MANIFESTATIONS; VIRULENCE; CORRELATE; OUTBREAK; CHILDREN; LESSONS
AB Background: It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand.
Methodology/Principal Findings: Prospective studies were conducted from 1994 to 2006. Univariate and multivariate logistic and multinomial logistic regressions were used to determine if dengue hemorrhagic fever (DHF) and signs of severe clinical disease (pleural effusion, ascites, thrombocytopenia, hemoconcentration) were associated with serotype. Crude and adjusted odds ratios were calculated. There were 162 (36%) cases with DENV-1, 102 (23%) with DENV-2, 123 (27%) with DENV-3, and 64 (14%) with DENV-4. There was no significant difference in the rates of DHF by serotype: DENV-2 (43%), DENV-3 (39%), DENV-1 (34%), DENV-4 (31%). DENV-2 was significantly associated with increased odds of DHF grade I compared to DF (OR 2.9 95% CI 1.1, 8.0), when using DENV-1 as the reference. Though not statistically significant, DENV-2 had an increased odds of total DHF and DHF grades II, III, and IV. Secondary serologic response was significantly associated with DHF (OR 6.2) and increased when considering more severe grades of DHF. DENV-2 (9%) and -4 (3%) were significantly less often associated with primary disease than DENV-1 (28%) and -3 (33%). Restricting analysis to secondary cases, we found DENV-2 and DENV-3 to be twice as likely to result in DHF as DEN-4 (p = 0.05). Comparing study years, we found the rate of DHF to be significantly less in 1999, 2000, 2004, and 2005 than in 1994, the study year with the highest percentage of DHF cases, even when controlling for other variables.
Conclusions/Significance: As in other studies, we find secondary disease to be strongly associated with DHF and with more severe grades of DHF. DENV-2 appears to be marginally associated with more severe dengue disease as evidenced by a significant association with DHF grade I when compared to DENV-1. In addition, we found non-significant trends with other grades of DHF. Restricting the analysis to secondary disease we found DENV-2 and -3 to be twice as likely to result in DHF as DEN-4. Differences in severity by study year may suggest that other factors besides serotype play a role in disease severity.
C1 [Fried, Jessica R.] Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok 10700, Thailand.
[Gibbons, Robert V.; Thomas, Stephen J.; Yoon, In-Kyu; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
[Srikiatkhachorn, Anon; Green, Sharone; Rothman, Alan L.] Univ Massachusetts, Sch Med, Worcester, MA USA.
[Cummings, Derek A. T.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
RP Fried, JR (reprint author), Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Fac Trop Med, Bangkok 10700, Thailand.
EM jessica@tropmedres.ac
FU NIH [P01 AI034533, U01-GM070708]; U.S. Army Medical Research and
Materiel Command; Bill & Melinda Gates Foundation; Burroughs Wellcome
Fund
FX The studies were supported in part by NIH grant P01 AI034533 and the
U.S. Army Medical Research and Materiel Command. DATC's work on this
project was funded by grants from the NIH (U01-GM070708) and the Bill &
Melinda Gates Foundation. DATC also holds a Career Award at the
Scientific Interface from the Burroughs Wellcome Fund. No funders had a
role in data analysis, preparation of the manuscript, or decision to
publish.
NR 37
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U1 3
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAR
PY 2010
VL 4
IS 3
AR e617
DI 10.1371/journal.pntd.0000617
PG 6
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 578RG
UT WOS:000276312200031
PM 20209155
ER
PT J
AU Mwamukonda, K
Chen, Y
Ravindranath, L
Furusato, B
Hu, Y
Sterbis, J
Osborn, D
Rosner, I
Sesterhenn, IA
McLeod, DG
Srivastava, S
Petrovics, G
AF Mwamukonda, K.
Chen, Y.
Ravindranath, L.
Furusato, B.
Hu, Y.
Sterbis, J.
Osborn, D.
Rosner, I.
Sesterhenn, I. A.
McLeod, D. G.
Srivastava, S.
Petrovics, G.
TI Quantitative expression of TMPRSS2 transcript in prostate tumor cells
reflects TMPRSS2-ERG fusion status
SO PROSTATE CANCER AND PROSTATIC DISEASES
LA English
DT Article
DE TMPRSS2; quantitative expression; TMPRSS2-ERG fusion
ID SERINE-PROTEASE TMPRSS2; CANCER; GENE; TRANSMEMBRANE; TISSUES
AB TMPRSS2-ERG fusion is the most common oncogenic rearrangement in prostate cancer (CaP). Owing to this chromosomal rearrangement one TMPRSS2 allele loses its promoter, and one of the ETS-related gene (ERG) alleles gains that promoter leading to its overexpression in these tumor cells. Some studies suggest that TMPRSS2, an androgen-regulated type II transmembrane serine protease, may have an effect on CaP progression. We hypothesized that a difference in TMPRSS2 expression may be present in vivo between CaP cells with and without TMPRSS2-ERG fusion, or a compensatory mechanism for the allelic loss of TMPRSS2 may balance that expression difference. Therefore, TMPRSS2 mRNA expression was evaluated in microdissected CaP cells with and without TMPRSS2-ERG fusion in 132 CaP patients and analyzed for its correlation with other androgen receptor (AR)-regulated genes and clinicopathological features. In vivo TMPRSS2 expression correlated with that of other AR-regulated genes, including PSA/KLK3 and PMEPA1, offering potential as AR surrogates. A significantly reduced expression of TMPRSS2 was evident in malignant cells harboring TMPRSS2-ERG fusion, but not in CaP cells without TMPRSS2-ERG fusion, further defining these two genetically distinct types of CaP. Prostate Cancer and Prostatic Diseases (2010) 13, 47-51; doi:10.1038/pcan.2009.28; published online 14 July 2009
C1 [Chen, Y.; Ravindranath, L.; Furusato, B.; Hu, Y.; McLeod, D. G.; Srivastava, S.; Petrovics, G.] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA.
[Mwamukonda, K.; Sterbis, J.; Osborn, D.; Rosner, I.; McLeod, D. G.] Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA.
[Furusato, B.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA.
[McLeod, D. G.; Srivastava, S.] Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA.
RP Petrovics, G (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA.
EM ssrivastava@cpdr.org; gpetrovics@cpdr.org
OI Furusato, Bungo/0000-0003-4614-9882
FU National Institutes of Health [5R01 DK065977]
FX This work was supported in part by grant 5R01 DK065977 for SS and GP
from the National Institutes of Health. The views expressed in this
paper are those of the authors and do not reflect the official policy of
the Department of the Army, Department of Defense or the US Government.
NR 15
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U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1365-7852
J9 PROSTATE CANCER P D
JI Prostate Cancer Prostatic Dis.
PD MAR
PY 2010
VL 13
IS 1
BP 47
EP 51
DI 10.1038/pcan.2009.28
PG 5
WC Oncology; Urology & Nephrology
SC Oncology; Urology & Nephrology
GA 553WM
UT WOS:000274397500008
PM 19597533
ER
PT J
AU Capaldi, VF
Wynn, GH
AF Capaldi, Vincent F., II
Wynn, Gary H.
TI Post Stroke Depression: Treatments and Complications in a Young Adult
SO PSYCHIATRIC QUARTERLY
LA English
DT Article
DE Post stroke depression; Brainstem stroke; Migrainous vasospasm; TCA;
SSRI; Methylphenidate; Aripiprazole; Suicidality
ID POSTSTROKE DEPRESSION; DOUBLE-BLIND; VASCULAR DEPRESSION; PSEUDOBULBAR
AFFECT; ARTERY-OCCLUSION; RECOVERY; PLACEBO; SERTRALINE; DISORDERS;
METHYLPHENIDATE
AB Post-stroke depression has been noted to be one of the most frequent complications of stroke with an estimated prevalence of as high as 80%. However, the incidence of stroke in the young is extremely low and evidence based therapy for this complication is quite limited. The case of a 28-year-old woman who experienced a basilar artery vasospasmic stroke resulting in anoxic brain injury to the midbrain and paramedian thalamus is presented, along with a literature review of psychiatric complications of this injury to include post-stroke depression (PSD). Therapeutic modalities such as TCAs, SSRIs, atypical antipsychotics and stimulant medications are also reviewed as these medications may aid in the treatment of such patients but may also contribute to psychiatric sequelae.
C1 [Capaldi, Vincent F., II; Wynn, Gary H.] Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA.
[Capaldi, Vincent F., II; Wynn, Gary H.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
RP Capaldi, VF (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, 6900 Georgia Ave, Washington, DC 20307 USA.
EM vin@capaldi.org
RI Wynn, Gary/B-3618-2011
NR 36
TC 1
Z9 2
U1 3
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2720
J9 PSYCHIAT QUART
JI Psychiatr. Q.
PD MAR
PY 2010
VL 81
IS 1
BP 73
EP 79
DI 10.1007/s11126-009-9120-8
PG 7
WC Psychiatry
SC Psychiatry
GA 552ZP
UT WOS:000274334100006
PM 20033774
ER
PT J
AU Ritchie, G
Harvey, DJ
Stroeher, U
Feldmann, F
Feldmann, H
Wahl-Jensen, V
Royle, L
Dwek, RA
Rudd, PM
AF Ritchie, Gayle
Harvey, David J.
Stroeher, Ute
Feldmann, Friederike
Feldmann, Heinz
Wahl-Jensen, Victoria
Royle, Louise
Dwek, Raymond A.
Rudd, Pauline M.
TI Identification of N-glycans from Ebola virus glycoproteins by
matrix-assisted laser desorption/ionisation time-of-flight and negative
ion electrospray tandem mass spectrometry
SO RAPID COMMUNICATIONS IN MASS SPECTROMETRY
LA English
DT Article
ID MARBURG VIRUS; LINKED GLYCANS; HEMORRHAGIC-FEVER; DESORPTION IONIZATION;
VIRION GLYCOPROTEINS; CELLULAR ENTRY; DC-SIGN; FRAGMENTATION; SGP;
INFECTION
AB The larger fragment of the transmembrane glycoprotein (GP1) and the soluble glycoprotein (sGP) of Ebola virus were expressed in human embryonic kidney cells and the secreted products were purified from the supernatant for carbohydrate analysis. The N-glycans were released with PNGase F from within sodium dodecyl sulphate/polyacrylamide gel electrophoresis (SDS-PAGE) gels. Identification of the glycans was made with normal-phase high-performance liquid chromatography (HPLC), matrix-assisted laser desorption/ionisation mass spectrometry, negative ion electrospray ionisation fragmentation mass spectrometry and exoglycosidase digestion. Most glycans were complex bi-, tri- and tetra-antennary compounds with reduced amounts of galactose. No bisected compounds were detected. Triantennary glycans were branched on the 6-antenna; fucose was attached to the core GlcNAc residue. Sialylated glycans were present on sGP but were largely absent from GP1, the larger fragment of the transmembrane glycoprotein. Consistent with this was the generally higher level of processing of carbohydrates found on sGP as evidenced by a higher percentage of galactose and lower levels of high-mannose glycans than were found on GP1. These results confirm and expand previous findings on partial characterisation of the Ebola virus transmembrane glycoprotein. They represent the first detailed data on carbohydrate structures of the Ebola virus sGP. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Ritchie, Gayle; Harvey, David J.; Dwek, Raymond A.] Univ Oxford, Dept Biochem, Oxford Glycobiol Inst, Oxford OX1 3QU, England.
[Stroeher, Ute; Feldmann, Friederike; Feldmann, Heinz; Wahl-Jensen, Victoria] Publ Hlth Agcy Canada, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada.
[Stroeher, Ute; Feldmann, Friederike; Feldmann, Heinz] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0W3, Canada.
[Wahl-Jensen, Victoria] USA, Viral Therapeut Branch, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Royle, Louise; Rudd, Pauline M.] Univ Coll Dublin, Natl Inst Bioproc Res & Training, Conway Inst, Dublin 4, Ireland.
RP Harvey, DJ (reprint author), Univ Oxford, Dept Biochem, Oxford Glycobiol Inst, S Parks Rd, Oxford OX1 3QU, England.
EM david.harvey@bioch.ox.ac.uk
RI Harvey, David/A-5579-2013
FU Public Health Agency of Canada
FX We thank Brian Matthews for releasing the O-linked glycans with
hydrazine. We also thank the Wellcome Trust and the Biotechnology and
Biological Sciences Research Council for equipment grants to purchase
the Q-Tof and TofSpec mass spectrometers, respectively. Studies on
filoviruses at the National Microbiology Laboratory in Winnipeg were
funded by the Public Health Agency of Canada.
NR 61
TC 15
Z9 15
U1 1
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-4198
EI 1097-0231
J9 RAPID COMMUN MASS SP
JI Rapid Commun. Mass Spectrom.
PD MAR
PY 2010
VL 24
IS 5
BP 571
EP 585
DI 10.1002/rcm.4410
PG 15
WC Biochemical Research Methods; Chemistry, Analytical; Spectroscopy
SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy
GA 573MT
UT WOS:000275918700015
PM 20131323
ER
PT J
AU Chason, RJ
Beall, SA
Csokmay, JM
Benne, MB
Segars, JH
AF Chason, Rebecca J.
Beall, Stephanie A.
Csokmay, John M.
Benne, Melinda B.
Segars, James H.
TI Oocyte Maturation Failure: Incidence and Prognosis for Pregnancy at
Assisted Reproduction
SO REPRODUCTIVE SCIENCES
LA English
DT Meeting Abstract
CT 57th Annual Meeting of the Society-for-Gynecologic-Investigation
CY MAR 24-27, 2010
CL Orlando, FL
SP Soc Gynecol Investigat
C1 [Beall, Stephanie A.] Vanderbilt Univ, Nashville, TN USA.
[Chason, Rebecca J.; Csokmay, John M.; Benne, Melinda B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Chason, Rebecca J.; Csokmay, John M.; Segars, James H.] NICHHD, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1933-7191
J9 REPROD SCI
JI Reprod. Sci.
PD MAR
PY 2010
VL 17
IS 3
SU S
MA 989
BP 349A
EP 349A
PG 1
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 568XE
UT WOS:000275558601461
ER
PT J
AU Risinger, JI
Chandramouli, GVR
Maxwell, GL
AF Risinger, John I.
Chandramouli, G. V. R.
Maxwell, G. Larry
TI MicroRNA Profiles of Serous and Endometrioid Endometrial Cancers.
SO REPRODUCTIVE SCIENCES
LA English
DT Meeting Abstract
CT 57th Annual Meeting of the Society-for-Gynecologic-Investigation
CY MAR 24-27, 2010
CL Orlando, FL
SP Soc Gynecol Investigat
C1 [Risinger, John I.; Chandramouli, G. V. R.] Michigan State Univ, Coll Human Med, Dept Obstet Gynecol & Reprod Biol, Grand Rapids, MI USA.
[Maxwell, G. Larry] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1933-7191
J9 REPROD SCI
JI Reprod. Sci.
PD MAR
PY 2010
VL 17
IS 3
SU S
MA 1011
BP 356A
EP 356A
PG 1
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 568XE
UT WOS:000275558601483
ER
PT J
AU Bellar, DM
Kamimori, GH
Glickman, EL
AF Bellar, David M.
Kamimori, Gary H.
Glickman, Ellen L.
TI Effects of Caffeine on Rating of Perceived Exertion and Pain During
Anaerobic Testing
SO RESEARCH QUARTERLY FOR EXERCISE AND SPORT
LA English
DT Meeting Abstract
C1 [Bellar, David M.] Univ Louisiana Lafayette, Lafayette, LA USA.
[Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Glickman, Ellen L.] Kent State Univ, Kent, OH USA.
EM davidbellar@mac.com
NR 0
TC 0
Z9 0
U1 2
U2 4
PU AMER ALLIANCE HEALTH PHYS EDUC REC & DANCE
PI RESTON
PA 1900 ASSOCIATION DRIVE, RESTON, VA 22091 USA
SN 0270-1367
J9 RES Q EXERCISE SPORT
JI Res. Q. Exerc. Sport
PD MAR
PY 2010
VL 81
IS 1
SU S
BP 13
EP 14
PG 2
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
Sport Sciences
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA 567HK
UT WOS:000275436700037
ER
PT J
AU Deng, WW
Waits, CM
Gomez, A
AF Deng, Weiwei
Waits, C. Mike
Gomez, Alessandro
TI Digital electrospray for controlled deposition
SO REVIEW OF SCIENTIFIC INSTRUMENTS
LA English
DT Article
DE damping; electrodeposition; ink jet printing; liquid phase deposition;
microfabrication; polymers; spraying; suspensions; viscosity
ID JET; CELLS
AB Many novel functional structures are now fabricated by controlled deposition as a maskless, bottom-up fabrication technique. These applications require rapid and precise deposition of minute amounts of solutions/suspensions or their ultimate particle products in predefined patterns. The electrospray is a promising alternative to the commonly used inkjet printing because it can easily handle highly viscous liquid, avoid high shear rates, and has low risk of clogging. We demonstrate a proof-of-concept digital electrospray. This system consists of a 61-nozzle array microfabricated in silicon and a 61-element digital extractor fabricated using flexible polyimide substrates. "Digital" refers to the state of each electrospray source that can be tuned either on or off independently and responsively. We showed a resolution of 675 mu m and a response frequency up to 100 Hz. With similar design and industry standard fabrication procedures, it is feasible to scale up the system to O(1000) sources with spatial resolution better than 250 mu m and a O(kHz) response frequency. The latter is controlled by the viscous damping time.
C1 [Deng, Weiwei; Gomez, Alessandro] Yale Univ, Dept Mech Engn, New Haven, CT 06520 USA.
[Waits, C. Mike] USA, Res Lab, Adelphi, MD 20783 USA.
RP Gomez, A (reprint author), Yale Univ, Dept Mech Engn, 9 Hillhouse Ave, New Haven, CT 06520 USA.
EM alessandro.gomez@yale.edu
RI Deng, Weiwei/C-2957-2011
FU U.S. Army [W911NF-05-2-0015]
FX We thank Mr. Edward Jackson from the Department of Electrical
Engineering at Yale University for his help in designing the control
panel and Mr. Eric Dube from Tech-Etch for his help in designing the
digital extractor. The support of the U.S. Army under Cooperative
Agreement No. W911NF-05-2-0015 is gratefully acknowledged.
NR 17
TC 5
Z9 5
U1 0
U2 18
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
MELVILLE, NY 11747-4501 USA
SN 0034-6748
J9 REV SCI INSTRUM
JI Rev. Sci. Instrum.
PD MAR
PY 2010
VL 81
IS 3
AR 035114
DI 10.1063/1.3340907
PG 6
WC Instruments & Instrumentation; Physics, Applied
SC Instruments & Instrumentation; Physics
GA 577GJ
UT WOS:000276210200068
PM 20370220
ER
PT J
AU Holthoff, E
Bender, J
Pellegrino, P
Fisher, A
AF Holthoff, Ellen
Bender, John
Pellegrino, Paul
Fisher, Almon
TI Quantum Cascade Laser-Based Photoacoustic Spectroscopy for Trace Vapor
Detection and Molecular Discrimination
SO SENSORS
LA English
DT Article
DE photoacoustic spectroscopy; sensor; quantum cascade laser; MEMS;
chemometrics
ID CHEMICAL SENSOR; MINIATURIZATION; INTEGRATION; CELL
AB We report on the development of a microelectromechanical systems (MEMS)-scale photoacoustic sensor for the detection of trace gases. A mid-infrared quantum cascade laser (QCL) was used to determine detection limits for acetic acid, acetone, 1,4-dioxane, and vinyl acetate. The source was continuously tunable from 1015 cm(-1) to 1240 cm(-1), allowing for the collection of photoacoustic vibrational spectra for these gases. Exceptional agreement between the measured photoacoustic spectra and the infrared spectra for acetic acid, acetone, 1,4-dioxane, and vinyl acetate was observed. Partial least-squares (PLS) regression was used to develop an algorithm for classification of these compounds based solely on photoacoustic spectra.
C1 [Holthoff, Ellen; Bender, John; Pellegrino, Paul] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA.
[Fisher, Almon] Infoton Technol Ctr, Canandaigua, NY 14424 USA.
RP Holthoff, E (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM ellen.holthoff@us.army.mil; john.s.bender@us.army.mil;
ppellegr@arl.army.mil; almon.fisher@ITCMEMS.com
NR 23
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Z9 41
U1 0
U2 11
PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
PI BASEL
PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND
SN 1424-8220
J9 SENSORS-BASEL
JI Sensors
PD MAR
PY 2010
VL 10
IS 3
BP 1986
EP 2002
DI 10.3390/s100301986
PG 17
WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
SC Chemistry; Electrochemistry; Instruments & Instrumentation
GA 589NY
UT WOS:000277158300032
PM 22294910
ER
PT J
AU Wasif, N
Faries, MB
Saha, S
Turner, RR
Wiese, DD
McCarter, MD
Shen, P
Stojadinovic, A
Bilchik, AJ
AF Wasif, Nabil
Faries, Mark B.
Saha, Sukamal
Turner, Roderick R.
Wiese, David D.
McCarter, Martin D.
Shen, Perry
Stojadinovic, Alexander
Bilchik, Anton J.
TI Predictors of occult nodal metastasis in colon cancer: Results from a
prospective multicenter trial
SO SURGERY
LA English
DT Article
ID REGIONAL LYMPH-NODES; COLORECTAL-CANCER; MICROMETASTASES; CARCINOMA;
RECURRENCE; RISK
AB Background. The relationship between primary colon cancer and occult nodal metastases (OMs) detected, by cytokeratin immunohistochemistry (CK-IHC) is unknown. We sought to investigate the correlation of clinicopathologic features of colon cancer with OMs and. to identify predictors of OM.
Methods. Patients with colon cancer from 5 tertiary referral cancer centers enrolled in a prospective trial of staging had standard pathologic analysis performed on all resected lymph, nodes (using hematoxylin and eosin staining [H&E]). Nodes negative on H&E underwent CK-IHC to detect OMs, which were defined as micrometastases (N1mic) or isolated tumor cells (N0i+). Patients who were negative on both H&E and CK-IHC were defined (is node negative (NN), and those positive on H&E were node positive (NP). The relationships between tumor characteristics and OMs were analyzed using the Kruskal-Wallis and the Fisher exact. test.
Results. OMs were identified in 23.4% (25/107) of patients. No significant differences were found, in demographics, tumor location, tumor size, and number of nodes examined between groups. Compared with the NN group, patients with OMs had more tumors that were T3/T4 (72% vs 57%; P < .001), had tumors of higher grade (28% vs 12%; P = .022), and had tumors with lymphovascular invasion (16% vs 3%; P <. 001).
Conclusion. Adverse primary pathologic colon cancer characteristics correlate with OMs. In patients with negative nodes on H&E. and stage T3/T4 colon cancer, lymphovascular invasion, or high tumor grade, consideration should given to performing CK-IHC. the detection of OMs in this subset may influence decisions regarding adjuvant chemotherapy and risk stratification. (Surgery 2010;147:352-7.)
C1 [Bilchik, Anton J.] Univ Calif Los Angeles, David Geffen Sch Med, Santa Monica, CA 90404 USA.
[Wasif, Nabil; Faries, Mark B.; Turner, Roderick R.] St Johns Hlth Ctr, John Wayne Canc Inst, Santa Monica, CA USA.
[Bilchik, Anton J.] Calif Oncol Res Inst, Santa Monica, CA USA.
[Saha, Sukamal; Wiese, David D.] Michigan State Univ, McLaren Reg Med Ctr, Flint, MI USA.
[McCarter, Martin D.] Univ Colorado, Dept Surg, Div GI Tumors & Endocrine Surg, Denver, CO 80202 USA.
[McCarter, Martin D.] Univ Colorado, Hlth Sci Ctr, Denver, CO USA.
[Shen, Perry] Wake Forest Univ, Med Ctr, Dept Surg Oncol, Winston Salem, NC USA.
[Stojadinovic, Alexander] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA.
RP Bilchik, AJ (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, 2336 Santa Monica Blvd,Suite 206, Santa Monica, CA 90404 USA.
EM abilchik@mednet.ucla.edu
FU National Cancer Institute [2RO1CA090848-05A2]; William Randolph Hearst
Foundation; Joyce E. and Ben B. Eisenberg Foundation; Davidow Charitable
Food; Sequouia Foundation; Mrs. Ruth Weil; Rod Fasone Memorial Cancer
Fund; Henry L. Guenther Foundation
FX supported by Grant 2RO1CA090848-05A2 from the National Cancer Institute
and by funding from the William Randolph Hearst Foundation (San
Francisco, CA), The Joyce E. and Ben B. Eisenberg Foundation (Los
Angeles, CA), Davidow Charitable Food (Los Angeles, CA), the Sequouia
Foundation, Mrs. Ruth Weil (Los Angeles, CA), the Rod Fasone Memorial
Cancer Fund (Los Angeles, CA), and the Henry L. Guenther Foundation (Los
Angeles, CA).
NR 23
TC 16
Z9 16
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD MAR
PY 2010
VL 147
IS 3
BP 352
EP 357
DI 10.1016/j.surg.2009.10.008
PG 6
WC Surgery
SC Surgery
GA 566DQ
UT WOS:000275350700005
PM 20116081
ER
PT J
AU Kosaraju, A
Barrigan, CR
Poropatich, RK
Casscells, SW
AF Kosaraju, Akhila
Barrigan, Cynthia R.
Poropatich, Ronald K.
Casscells, Samuel Ward
TI Use of Mobile Phones as a Tool for United States Health Diplomacy Abroad
SO TELEMEDICINE JOURNAL AND E-HEALTH
LA English
DT Article
DE policy; telehealth; military medicine
ID SHORT-MESSAGE SERVICE
AB Rapidly emerging mobile communications platforms, such as mobile phones, in countries across Africa, Iraq, and Afghanistan offer new opportunities for direct public engagement in health systems, placing tools and timely information into the hands of those who need it most. Early results from pioneering work suggest real benefits of mobile devices in addressing access to care, monitoring and treating diseases, and providing continuous medical education and training. The Military Health System, a $43-billion global healthcare system within the U.S. Department of Defense, in partnership with other U.S. government agencies and nongovernmental organizations and the international health sector, can make valuable contributions to creating a sustainable global m-health infrastructure.
C1 [Kosaraju, Akhila] Hlth Affairs, Dept Def, Washington, DC 20301 USA.
[Barrigan, Cynthia R.; Poropatich, Ronald K.] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
[Poropatich, Ronald K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Casscells, Samuel Ward] Univ Texas Austin, Hlth Sci Ctr, Austin, TX USA.
RP Kosaraju, A (reprint author), Hlth Affairs, Dept Def, 1200 Def Pentagon, Washington, DC 20301 USA.
EM akhila.kosaraju@ha.osd.mil
NR 22
TC 5
Z9 5
U1 1
U2 16
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-5627
J9 TELEMED J E-HEALTH
JI Telemed. J. e-Health
PD MAR
PY 2010
VL 16
IS 2
BP 219
EP 223
DI 10.1089/tmj.2009.0095
PG 5
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA 571MS
UT WOS:000275756500012
PM 20156128
ER
PT J
AU O'Donnell, JC
McDonough, JH
Shih, TM
AF O'Donnell, John C.
McDonough, John H.
Shih, Tsung-Ming
TI Changes in extracellular striatal acetylcholine and brain seizure
activity following acute exposure to nerve agents in freely moving
guinea pigs
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Article
DE Acetylcholine; acetylcholinesterase; choline; guinea pig; in vivo
microdialysis; nerve agents; organophosphorus compounds; sarin; seizure
activity; soman; VR; VX
ID SOMAN-INDUCED SEIZURES; CARBOXYLESTERASE INHIBITION; ATROPINE SULFATE;
ORGANOPHOSPHORUS; TOXICITY; EFFICACY; BARRIER; MICRODIALYSIS;
MECHANISMS; RATS
AB Organophosphorus nerve agents irreversibly inhibit acetylcholinesterase (AChE) in the peripheral and central nervous systems, causing an increase in the concentration of acetylcholine (ACh) in the synapse or neuromuscular junction and subsequent adverse effects. In this study, in vivo microdialysis was utilized to collect samples from the striatum for monitoring changes in extracellular ACh levels along with cortical electroencephalographic (EEG) recordings for identifying seizure activity after acute subcutaneous (s.c.) exposure to 1.0 x LD(50) of the nerve agents sarin, soman, or one of two V-type agents (VX, or a Russian V-agent, designated VR) in unanesthetized freely moving guinea pigs. Based on EEG recordings, these animals were subsequently divided into groups that developed seizures (S) and those that did not develop seizures (NS). Maximum ACh levels in the striatum were observed at 60-70 min for sarin and soman S groups and 105 min for VX and VR S groups. In all NS groups the greatest increase in extracellular ACh occurred within 30 min after exposure, although in the sarin NS group a few sporadic increases of ACh from control occurred. Animals that developed seizures, regardless of the nerve agent, had significantly higher extracellular striatal ACh levels compared to the controls or those animals that did not develop seizures, yet both S and NS groups displayed similar levels of blood AChE inhibition. Regardless of the agent, all animals in the non-seizure groups survived 24 h, while lethality (25-42%) was observed only in animals that experienced seizure activity.
C1 [O'Donnell, John C.; McDonough, John H.; Shih, Tsung-Ming] USA, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Shih, TM (reprint author), USA, Med Res Inst Chem Def, Div Res, Pharmacol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM tsungming.a.shih@us.army.mil
FU Defense Threat Reduction Agency-Joint Service and Technology Office,
Medical Science and Technology Division
FX The authors express their appreciation for the excellent technical
assistance of Steven Raiker, Kathleen McAvoy, Cindy Acon-Chen, Jeffrey
Koenig, Teresa Ferrara, and Dr Bruce J. Jung. This research was
supported by the Defense Threat Reduction Agency-Joint Service and
Technology Office, Medical Science and Technology Division.
NR 38
TC 3
Z9 4
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PD MAR
PY 2010
VL 20
IS 3
BP 143
EP 152
DI 10.3109/15376511003657439
PG 10
WC Toxicology
SC Toxicology
GA 560FD
UT WOS:000274886500007
PM 20163292
ER
PT J
AU Diniz, PPVP
Beall, MJ
Omark, K
Chandrashekar, R
Daniluk, DA
Cyr, KE
Koterski, JF
Robbins, RG
Lalo, PG
Hegarty, BC
Breitschwerdt, EB
AF Diniz, Pedro Paulo V. P.
Beall, Melissa J.
Omark, Karina
Chandrashekar, Ramaswamy
Daniluk, Daryn A.
Cyr, Katie E.
Koterski, James F.
Robbins, Richard G.
Lalo, Pamela G.
Hegarty, Barbara C.
Breitschwerdt, Edward B.
TI High Prevalence of Tick-Borne Pathogens in Dogs from an Indian
Reservation in Northeastern Arizona
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Anaplasma; Babesia; Bartonella; Ehrlichia; Rickettsia; Sentinel
ID SPOTTED-FEVER GROUP; CONSERVED IMMUNODOMINANT REGION;
RHIPICEPHALUS-SANGUINEUS TICKS; EHRLICHIA-CANIS INFECTION;
RICKETTSIA-RICKETTSII; BORRELIA-BURGDORFERI; UNITED-STATES;
ANAPLASMA-PLATYS; EASTERN ARIZONA; VECTOR
AB We evaluated the serological and molecular prevalence of selected organisms in 145 dogs during late spring (May/June) of 2005 and in 88 dogs during winter (February) of 2007 from the Hopi Indian reservation. Additionally, in 2005, 442 ticks attached to dogs were collected and identified as Rhipicephalus sanguineus. Infection with or exposure to at least one organism was detected in 69% and 66% of the dogs in May/June 2005 and February 2007, respectively. Exposure to spotted fever group (SFG) rickettsiae was detected in 66.4% (2005) and 53.4% (2007) of dogs, but rickettsial DNA was not detected using polymerase chain reaction. Active Ehrlichia canis infection (by polymerase chain reaction) was identified in 36.6% (2005) and 36.3% (2007) of the dogs. E. canis infection was associated with SFG rickettsiae seroreactivity (p < 0.001). Anaplasma platys DNA was detected in 8.3% (2005) and 4.5% (2007) of the dogs. Babesia canis and Bartonella vinsonii berkhoffii seroprevalences were 6.7% and 1% in 2005, whereas in 2007 prevalences were 0% and 1.1%, respectively. No Bartonella spp., Ehrlichia chaffeensis, or Ehrlichia ewingii DNA was detected. Dogs on this Hopi Indian reservation were most frequently infected with E. canis or A. platys; however, more than half of the dogs were exposed to a SFG-Rickettsia species.
C1 [Diniz, Pedro Paulo V. P.; Hegarty, Barbara C.; Breitschwerdt, Edward B.] N Carolina State Univ, Coll Vet Med, Intracellular Pathogens Res Lab, Ctr Comparat Med & Translat Res, Raleigh, NC 27606 USA.
[Beall, Melissa J.; Chandrashekar, Ramaswamy; Daniluk, Daryn A.; Cyr, Katie E.] IDEXX Labs, Westbrook, ME USA.
[Omark, Karina] Yarmouth Vet Ctr, Yarmouth, ME USA.
[Koterski, James F.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Robbins, Richard G.] Walter Reed Army Med Ctr, DPMIAC, AFPMB, Washington, DC 20307 USA.
[Lalo, Pamela G.] Hopi Vet Serv, Polacca, AZ USA.
RP Breitschwerdt, EB (reprint author), N Carolina State Univ, Coll Vet Med, Intracellular Pathogens Res Lab, Ctr Comparat Med & Translat Res, 4700 Hillsborough St,Res Bldg,Room 454, Raleigh, NC 27606 USA.
EM ed_breitschwerdt@ncsu.edu
RI Diniz, Pedro Paulo/B-2794-2013
FU IDEXX(R) Laboratories
FX Dr. Pedro Diniz's stipend was supported by IDEXX (R) Laboratories as
part of this study.
NR 48
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U1 1
U2 7
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD MAR
PY 2010
VL 10
IS 2
BP 117
EP 123
DI 10.1089/vbz.2008.0184
PG 7
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 575PS
UT WOS:000276080100003
PM 19469667
ER
PT J
AU O'Guinn, ML
Klein, TA
Lee, JS
Richards, AL
Kim, HC
Ha, SJ
Shim, SH
Baek, LJ
Song, KJ
Chong, ST
Turell, MJ
Burkett, DA
Schuster, A
Lee, IY
Yi, SH
Sames, WJ
Song, JW
AF O'Guinn, Monica L.
Klein, Terry A.
Lee, John S.
Richards, Allen L.
Kim, Heung-Chul
Ha, Si Jung
Shim, So Hee
Baek, Luck Ju
Song, Ki-Joon
Chong, Sung-Tae
Turell, Michael J.
Burkett, Douglas A.
Schuster, Anthony
Lee, In-Yong
Yi, Suk-Hee
Sames, William J.
Song, Jin-Won
TI Serological Surveillance of Scrub Typhus, Murine Typhus, and
Leptospirosis in Small Mammals Captured at Firing Points 10 and 60,
Gyeonggi Province, Republic of Korea, 2001-2005
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Apodemus; Crocidura; insectivores; leptospirosis; Micromys; Microtus;
murine typhus; Myodes; Orientia; Rattus; Rickettsia; rodents; scrub
typhus; Tscherskia
ID POLYMERASE-CHAIN-REACTION; SPOTTED-FEVER GROUP;
RICKETTSIA-TSUTSUGAMUSHI; CLINICAL-DIAGNOSIS; RAPID DIAGNOSIS;
INFECTION; DISEASE; RODENTS; THAILAND; HUMANS
AB Soldiers from the Republic of Korea and the United States conducting peacetime military operations at various training sites and multiple range complexes located near the demilitarized zone separating North and South Korea are exposed to rodents and their potentially disease-carrying ectoparasites. These diseases include scrub typhus, murine typhus, and leptospirosis. Many of the training sites are rural or semi-rural, surrounded or co-located with various forms of agriculture, and are infested with rodents and insectivores (as well as their ectoparasites), which are commonly found in association with unmanaged tall grasses, scrub, and crawling vegetation habitats. For 5 years, rodents and insectivores were collected seasonally (spring, summer, fall, and winter) at firing points 10 and 60 near the demilitarized zone and serologically tested for the presence of scrub typhus, murine typhus, and leptospirosis antibodies. Of the nine species of small mammals collected, Apodemus agrarius, the common striped field mouse and known reservoir of scrub typhus, was the most frequently collected (90.6%). Only four of the nine species captured, A. agrarius (60.9%), Micromys minutus (100%), Mus musculus (55.6%), and Rattus norvegicus (46.7%), were positive for scrub typhus. Of all the small mammals captured, only A. agrarius was positive for murine typhus (0.3%) and leptospirosis (1.3%). Seasonal and annual prevalence rates based on weight and sex are presented.
C1 [Ha, Si Jung; Shim, So Hee; Baek, Luck Ju; Song, Ki-Joon; Song, Jin-Won] Korea Univ, Dept Microbiol, Coll Med, Inst Viral Dis, Seoul 136705, South Korea.
[Ha, Si Jung; Shim, So Hee; Baek, Luck Ju; Song, Ki-Joon; Song, Jin-Won] Korea Univ, Dept Microbiol, Coll Med, Bank Pathogen Viruses, Seoul 136705, South Korea.
[O'Guinn, Monica L.; Lee, John S.; Turell, Michael J.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Klein, Terry A.; Yi, Suk-Hee; Sames, William J.] Force Hlth Protect 18th Med Command, Unit 15281, APO, AP 96205 USA.
[Richards, Allen L.] USN, Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA.
[Kim, Heung-Chul; Chong, Sung-Tae] 18th Med Command, Unit 15247, APO, AP 96205 USA.
[Burkett, Douglas A.] AF Inst Operat Hlth, Human Syst Wing 311, Unit 5213, Kadena AFB, Okinawa, Japan.
[Schuster, Anthony] Ctr Hlth Promot & Prevent Med S, Atlanta, GA USA.
[Lee, In-Yong] Yonsei Univ, Coll Med, Dept Environm Med Biol, Seoul, South Korea.
RP Song, JW (reprint author), Korea Univ, Dept Microbiol, Coll Med, Inst Viral Dis, 126-1,5Ka Anam Dong, Seoul 136705, South Korea.
EM jwsong@korea.ac.kr
RI Valle, Ruben/A-7512-2013
FU U.S. Department of Defense Global Emerging Infections Surveillance and
Response System, Silver Spring, MD; Armed Forces Medical Intelligence
Center, Fort Detrick, MD
FX Funding for portions of this work was provided by the U.S. Department of
Defense Global Emerging Infections Surveillance and Response System,
Silver Spring, MD, and the Armed Forces Medical Intelligence Center,
Fort Detrick, MD.
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U1 1
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD MAR
PY 2010
VL 10
IS 2
BP 125
EP 133
DI 10.1089/vbz.2008.0123
PG 9
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 575PS
UT WOS:000276080100004
PM 19402761
ER
PT J
AU Stuempfle, KJ
Nindl, BC
Kamimori, GH
AF Stuempfle, Kristin J.
Nindl, Bradley C.
Kamimori, Gary H.
TI Stress Hormone Responses to an Ultraendurance Race in the Cold
SO WILDERNESS & ENVIRONMENTAL MEDICINE
LA English
DT Article
DE ultraendurance race; cold; epinephrine; norepinephrine; ACTH; cortisol
ID PROLONGED PHYSICAL-EXERCISE; PLASMA-CORTISOL; NOREPINEPHRINE RESPONSES;
PHYSIOLOGICAL-RESPONSES; METABOLIC RESPONSES; EXHAUSTIVE EXERCISE;
BIOCHEMICAL-CHANGES; WATER; EXPOSURE; GENDER
AB Objective-Physical stress (exercise and/or environmental) activates the sympathetic-adrenal-medullary (SAM) and hypothalamic-pituitary-adrenocortical (HPA) axes. The combination of ultraendurance exercise in the cold presents a unique summated stress to the body. The purpose of this study was to assess the stress hormone response in runners, cyclists, and skiers participating in a 161-km ultraendurance race on a snow-packed course in the Alaskan wilderness.
Methods-Forty-four athletes (20 runners, 17 cyclists, 7 skiers) competed on the same course of snow-machine trails and ice roads with each athlete carrying 7 kg of mandatory equipment. Prerace weight and blood samples were collected 2 days prior to the race start. Postrace measurements were made within 15 minutes of race finish. Hematocrit was measured, and blood samples were analyzed for levels of norepinephrine, epinephrine, adrenocorticotropic hormone, and cortisol.
Results-Runners lost significant weight (-1.74 kg +/- 1.29) prerace to postrace. Hematocrit was maintained, and plasma volume increased minimally. Norepinephrine increased significantly prerace (279.9 pg/mL +/- 356.9) to postrace (691.7 pg/mL +/- 422.6) with no difference among divisions. Epinephrine did not change significantly during the race. Adrenocorticotropic hormone (2.40 pg/mL +/- 2.40 to 19.04 pg/mL +/- 45.38) increased significantly with no difference among divisions. Cortisol increased significantly prerace (12.03 mu g/dL +/- 5.66) to postrace (26.69 mu g/dL +/- 5.77), and postrace cortisol was significantly higher in runners vs skiers.
Conclusions-These data suggest activation of both the SAM and HPA axes from an ultraendurance race in the cold and reveal the degree of stress hormone responses to this exhausting bout of exercise.
C1 [Stuempfle, Kristin J.] Gettysburg Coll, Dept Hlth Sci, Gettysburg, PA 17325 USA.
[Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
[Kamimori, Gary H.] Walter Reed Army Inst Res, Washington, DC 20307 USA.
RP Stuempfle, KJ (reprint author), Gettysburg Coll, Dept Hlth Sci, Campus Box 432,300 N Washington St, Gettysburg, PA 17325 USA.
NR 39
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U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1080-6032
EI 1545-1534
J9 WILD ENVIRON MED
JI Wildern. Environ. Med.
PD SPR
PY 2010
VL 21
IS 1
BP 22
EP 27
DI 10.1016/j.wem.2009.12.020
PG 6
WC Public, Environmental & Occupational Health; Sport Sciences
SC Public, Environmental & Occupational Health; Sport Sciences
GA 632PS
UT WOS:000280437300005
PM 20591350
ER
PT J
AU Zhu, W
Ku, D
Zheng, JP
Liang, Z
Wang, B
Zhang, C
Walsh, S
Au, G
Plichta, EJ
AF Zhu, W.
Ku, D.
Zheng, J. P.
Liang, Z.
Wang, B.
Zhang, C.
Walsh, S.
Au, G.
Plichta, E. J.
TI Buckypaper-based catalytic electrodes for improving platinum utilization
and PEMFC's performance
SO ELECTROCHIMICA ACTA
LA English
DT Article
DE PEMFC; Carbon nanotube; Buckypaper; Electrocatalyst; Pt utilization
ID MEMBRANE FUEL-CELLS; CARBON NANOTUBES; SUPPORT MATERIAL; NANOPARTICLES;
REDUCTION; OXYGEN; ELECTROCATALYSTS; DEPOSITION; CATHODES; LAYER
AB Platinum (Pt) catalytic electrode was developed by using carbon nanotube films (buckypaper) as supporting medium and electrodeposition method to deposit Pt catalyst. Buckypapers are free-standing thin films consisting of single-walled carbon nanotubes (SWNTs), multi-walled carbon nanotubes (MWNTs) and/or carbon nanofibers (CNFs) held together by van der Waals forces without any chemical binders. Special mixed buckypapers was developed by layered microstructures with a dense and high-conducting SWNT networks at the surface, as well as large porous structures of CNF networks as back supports. This unique microstructure can lead to improve Pt catalyst accessibility and mass exchange properties. Pt particles of about 6 nm were uniformly deposited in porous buckypapers. A promising electrochemical surface area of similar to 40 m(2)/g was obtained from these electrodes. A Pt utilization as low as 0.28 g(pt)/kW was achieved for the cathode electrode at 80 degrees C. Pt utilization efficiency can be further improved by optimization of the electrodeposition condition in order to reduce the Pt particle size. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Zhu, W.; Zheng, J. P.] Florida State Univ, Coll Engn, Dept Elect & Comp Engn, Florida A&M Univ, Tallahassee, FL 32310 USA.
[Zhu, W.; Ku, D.; Liang, Z.; Wang, B.; Zhang, C.] Florida State Univ, Coll Engn, Dept Ind Engn, Florida A&M Univ, Tallahassee, FL 32310 USA.
[Zheng, J. P.] Florida State Univ, CAPS, Tallahassee, FL 32310 USA.
[Liang, Z.; Wang, B.; Zhang, C.] Florida State Univ, HPMI, Tallahassee, FL 32310 USA.
[Walsh, S.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Au, G.; Plichta, E. J.] USA, CERDEC, Ft Monmouth, NJ 07703 USA.
RP Zheng, JP (reprint author), Florida State Univ, Coll Engn, Dept Elect & Comp Engn, Florida A&M Univ, 2525 Pottsdamer St, Tallahassee, FL 32310 USA.
EM zheng@eng.fsu.edu; liang@eng.fsu.edu
RI Zhu, Wei/B-4159-2010
FU AFRL NOLES program; Army CERDEC
FX This research is partially supported by the AFRL NOLES program and Army
CERDEC.
NR 26
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U1 3
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0013-4686
J9 ELECTROCHIM ACTA
JI Electrochim. Acta
PD FEB 28
PY 2010
VL 55
IS 7
BP 2555
EP 2560
DI 10.1016/j.electacta.2009.12.026
PG 6
WC Electrochemistry
SC Electrochemistry
GA 568RL
UT WOS:000275540100054
ER
PT J
AU Slack, WT
Sumners, JA
Rooney, AP
Taylor, CM
AF Slack, William T.
Sumners, Jason A.
Rooney, Alejandro P.
Taylor, Christopher M.
TI Conservation Genetics of the Threatened Bayou Darter (Percidae:
Etheostoma rubrum) in the Bayou Pierre System of Southwestern
Mississippi
SO COPEIA
LA English
DT Article
ID POPULATION-STRUCTURE; INTEGRATED SOFTWARE; DNA VARIATION; MITOCHONDRIAL;
TELEOSTEI; PHYLOGEOGRAPHY; FISHES; RIVER
AB The Bayou Darter, Etheostoma rubrum, Is endemic to the Bayou Pierre system of southwestern Mississippi where it occupies swift, shallow riffles with coarse, firm substrata. The Bayou Pierre system has experienced extensive erosion in response to rapid headcutting leading to loss of riffle habitat and degradation of riverine conditions. Due to its high degree of habitat specificity along with ongoing habitat fragmentation and potentially reduced gene flow between Isolated populations, the Bayou Darter is vulnerable to severe population declines and possible extinction. Our objectives were to quantify levels of genetic diversity in the mitochondrial control region and Infer population structure across the range of the species. Sequencing of 106 sampled Individuals revealed only three mtDNA haplotypes with one variable site. Haplotype diversity and nucleotide diversity were low (h <= 0.11 and pi < 0.001), and there was no structure revealed among the four sampled populations. The low genetic diversity in E. rubrum may best be explained by a small range size and recent genetic bottleneck.
C1 [Slack, William T.] Res & Collect Program, Museum Nat Sci, Mississippi Dept Wildlife Fisheries & Pk, Jackson, MS 39202 USA.
[Sumners, Jason A.] Texas A&M Univ, Dept Wildlife & Fisheries Sci, College Stn, TX 77843 USA.
[Rooney, Alejandro P.] Mississippi State Univ, Dept Biol Sci, Mississippi State, MS 39762 USA.
[Taylor, Christopher M.] Texas Tech Univ, Dept Nat Resources Management, Lubbock, TX 79409 USA.
RP Slack, WT (reprint author), USA, Waterways Expt Stn, Engn Res & Dev Ctr, EE-A,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM todd.slack@usace.army.mil; jason.sumners@mdc.mo.gov;
alejandro.rooney@ars.usda.gov; cm.taylor@ttu.edu
NR 38
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U1 1
U2 8
PU AMER SOC ICHTHYOLOGISTS HERPETOLOGISTS
PI CHARLESTON
PA UNIV CHARLESTON, GRICE MARINE LABORATORY, 205 FORT JOHNSON RD,
CHARLESTON, SC 29412 USA
SN 0045-8511
J9 COPEIA
JI Copeia
PD FEB 26
PY 2010
IS 1
BP 176
EP 180
DI 10.1643/CG-09-055
PG 5
WC Zoology
SC Zoology
GA 564BI
UT WOS:000275185500020
ER
PT J
AU Chen, L
Bromberg, L
Lee, JA
Zhang, H
Schreuder-Gibson, H
Gibson, P
Walker, J
Hammond, PT
Hatton, TA
Rutledge, GC
AF Chen, Liang
Bromberg, Lev
Lee, Jung Ah
Zhang, Huan
Schreuder-Gibson, Heidi
Gibson, Phillip
Walker, John
Hammond, Paula T.
Hatton, T. Alan
Rutledge, Gregory C.
TI Multifunctional Electrospun Fabrics via Layer-by-Layer Electrostatic
Assembly for Chemical and Biological Protection
SO CHEMISTRY OF MATERIALS
LA English
DT Article
ID P-NITROPHENYL ACETATE; HYDROXAMIC ACIDS; ISOPROPYL
METHYLPHOSPHONOFLUORIDATE; ENVIRONMENTAL APPLICATIONS;
TRANSPORT-PROPERTIES; POLYMER NANOFIBERS; WARFARE AGENTS; FIBERS;
MEMBRANES; HYDROLYSIS
AB Breathable chemical and biological detoxifying protective fabrics are obtained via functionalization of electrospun fiber mats using a layer-by-layer electrostatic assembly technique. The chemically reactive polyanion, poly(N-hydroxyacrylamide) or poly(hydroxamic acid) (PHA), and bactericidal polycation, poly(N-vinylguanidine) (PVG), were synthesized and assembled electrostatically to generate multifunctional coatings on prefabricated polyacrylonitrile (PAN) fiber mats. Reactivity of PHA in the hydrolysis of diisopropyl fluorophosphate (DFP), a close analog of the chemical warfare agent sarin, was demonstrated. The DFP degradation rate with PHA is comparable to that with compounds such as isonicotinhydroxamic acid methiodide, an efficient catalyst of organophosphate ester hydrolysis. Protective fabrics functionalized with PVG/PHA layers are able to degrade DFP mists, with DFP hydrolysis rates 60-fold higher than those with unmodified fabrics under identical conditions. Fabrics modified with PVG/PHA layers are bactericidal against E. coli and S. epidermidis. Breathability of functionalized fiber mats as protective fabrics was evaluated versus standard reference fabrics.
C1 [Chen, Liang; Bromberg, Lev; Lee, Jung Ah; Zhang, Huan; Hammond, Paula T.; Hatton, T. Alan; Rutledge, Gregory C.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
[Schreuder-Gibson, Heidi; Gibson, Phillip; Walker, John] USA, Res Dev & Engn Command, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Hatton, TA (reprint author), MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
EM tahatton@mit.edu; rutledge@mit.edu
RI Gibson, Phillip/D-2398-2010
OI Gibson, Phillip/0000-0002-6172-4438
FU Department of the Army, U.S. Army Research Office [W911NF-07-1-0139];
DuPont-MIT Alliance
FX This work was sponsored in part by the Department of the Army, U.S. Army
Research Office, under Grant W911NF-07-1-0139. Any opinions, findings,
conclusions and recommendations expressed in this article are those of
the authors and do not necessarily reflect the views of the U.S. Army
Research Office. Partial support wits also provided by the DuPont-MIT
Alliance.
NR 66
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U1 6
U2 63
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0897-4756
J9 CHEM MATER
JI Chem. Mat.
PD FEB 23
PY 2010
VL 22
IS 4
BP 1429
EP 1436
DI 10.1021/cm902834a
PG 8
WC Chemistry, Physical; Materials Science, Multidisciplinary
SC Chemistry; Materials Science
GA 555RI
UT WOS:000274531300022
ER
PT J
AU Crum-Cianflone, NF
Hullsiek, KH
Marconi, VC
Ganesan, A
Weintrob, A
Barthel, RV
Agan, BK
AF Crum-Cianflone, Nancy F.
Hullsiek, Katherine Huppler
Marconi, Vincent C.
Ganesan, Anuradha
Weintrob, Amy
Barthel, Robert V.
Agan, Brian K.
CA Infect Dis Clinical Res Program
TI Anal cancers among HIV-infected persons: HAART is not slowing rising
incidence
SO AIDS
LA English
DT Article
DE anal cancer; antiretroviral therapy; epidemiology; HAART; HIV; incidence
rates
ID ACTIVE ANTIRETROVIRAL THERAPY; SQUAMOUS INTRAEPITHELIAL LESIONS;
HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN-PAPILLOMAVIRUS INFECTION;
UNITED-STATES; POSITIVE MEN; RISK-FACTOR; ERA; NEOPLASIA; TRENDS
AB Objective: To evaluate the incidence rates of anal cancer over the HIV epidemic and assess the impact of HAART use on anal cancer events.
Methods: We evaluated the incidence of and factors associated with anal cancer using longitudinal data from the prospective U. S. Military Natural History Study (19852008). Poisson regression and Cox proportional hazard models were utilized.
Results: Among 4506 HIV-infected men with 37 806 person-years of follow-up, anal cancer rates (per 100 000 person-years) increased five-fold, from 11 in the pre-HAART to 55 in the HAART era (P = 0.02). Rates continued to increase, reaching 128 in 2006-2008. Persons with HIV infection for more than 15 years had a 12-fold higher rate than those with less than 5 years (348 vs. 28, P < 0.01). At cancer diagnosis (n - 19), median age was 42 years, median CD4 cell count was 432 cells/mu l, 74% had a CD4 nadir cell count less than 200 cells/mu l, 42% had a prior AIDS event, and 74% had received HAART. From separate models, prior AIDS event (hazard ratio 3.88, P = 0.01) and lower CD4 nadir (hazard ratio 0.85 per 50 cell, P = 0.03) were associated with anal cancer, with a trend for a history of gonorrhea (hazard ratio 2.43, P = 0.07). Duration of HAART use was not associated with a reduced risk of anal cancer (hazard ratio 0.94, P = 0.42).
Conclusion: Incidence rates of anal cancer have progressively increased during the HIV epidemic. Persons with a longer duration of HIV infection have a substantially higher rate of anal cancer. As HIV-infected persons are experiencing longer life expectancies and HAART does not appear protective of anal cancer, studies on preventive strategies are needed. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
C1 [Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, Infect Dis Clin, Clin Invest Dept KCA, San Diego, CA 92134 USA.
[Crum-Cianflone, Nancy F.; Marconi, Vincent C.; Ganesan, Anuradha; Weintrob, Amy; Barthel, Robert V.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Hullsiek, Katherine Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
[Marconi, Vincent C.] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA.
[Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA.
[Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA.
[Barthel, Robert V.] Naval Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA.
RP Crum-Cianflone, NF (reprint author), Naval Med Ctr San Diego, Infect Dis Clin, Clin Invest Dept KCA, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA.
EM nancy.crum@med.navy.mil
RI Marconi, Vincent/N-3210-2014;
OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669
FU IDCRP [G187YS-RV168D]; National Institute of Allergy and Infectious
Diseases; National Institutes of Health (NIH) [Y1-AI-5072]
FX Support for this work (IDCRP # G187YS-RV168D) was provided by the
Infectious Disease Clinical Research Program (IDCRP), a Department of
Defense (DoD) program executed through the Uniformed Services University
of the Health Sciences. This project has been funded in whole, or in
part, with federal funds from the National Institute of Allergy and
Infectious Diseases, National Institutes of Health (NIH), under
Inter-Agency Agreement Y1-AI-5072. The content of this publication is
the sole responsibility of the authors and does not necessarily reflect
the views or policies of the NIH or the Department of Health and Human
Services, the DoD or the Departments of the Army, Navy, or Air Force.
Mention of trade names, commercial products, or organizations does not
imply endorsement by the U. S. Government. This work is original and has
not been published elsewhere.
NR 32
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
J9 AIDS
JI Aids
PD FEB 20
PY 2010
VL 24
IS 4
BP 535
EP 543
DI 10.1097/QAD.0b013e328331f6e2
PG 9
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 563QK
UT WOS:000275148000006
PM 19926961
ER
PT J
AU Landrum, ML
Hullsiek, KH
Ganesan, A
Weintrob, AC
Crum-Cianflone, NF
Barthel, RV
O'Connell, RJ
Fieberg, A
Chun, HM
Marconi, VC
Dolan, MJ
Agan, BK
AF Landrum, Michael L.
Hullsiek, Katherine Huppler
Ganesan, Anuradha
Weintrob, Amy C.
Crum-Cianflone, Nancy F.
Barthel, R. Vincent
O'Connell, Robert J.
Fieberg, Ann
Chun, Helen M.
Marconi, Vincent C.
Dolan, Matthew J.
Agan, Brian K.
CA Infect Dis Clinical Res Program
TI Hepatitis B vaccination and risk of hepatitis B infection in
HIV-infected individuals
SO AIDS
LA English
DT Article
DE hepatitis B vaccine; hepatitis B virus; human immunodeficiency virus;
immunization; vaccination
ID HUMAN-IMMUNODEFICIENCY-VIRUS; LONG-TERM IMMUNOGENICITY; T-CELL
RESPONSES; HOMOSEXUAL-MEN; ANTIRETROVIRAL THERAPY; UNITED-STATES;
EFFICACY; ANTIBODY; COHORT; TRIAL
AB Objective: To assess the association of hepatitis B virus (HBV) vaccination with risk of HBV infection among HIV-infected patients and HBV infection risk factors among vaccinees.
Design: Observational cohort study.
Methods: Participants enrolled from 1986 through 2004, unvaccinated and serologically negative for HBV infection at the time of HIV diagnosis, were followed longitudinally through 2007 for the occurrence of HBV infection. Risk factors for HBV infection were evaluated using time to event methods, including Kaplan-Meier survival curves and Cox proportional hazards models.
Results: During 11 632 person-years of follow-up, the rate of HBV infection was 2.01 (95% CI 1.75-2.27)/100 person-years. Receipt of at least one dose of vaccine was not associated with reduced risk of HBV (unadjusted hazard ratio 0.86, 95% CI 0.7-1.1; adjusted hazard ratio 1.08, 95% CI 0.8-1.4). Receipt of three or more doses of vaccine was also not associated with reduced risk (hazard ratio 0.96; 95% CI 0.56-1.64). Among 409 vaccinees with HBsAb less than 10 IU/l, 46 (11.2%) developed HBV infection compared with 11 of 217 (5.1%) vaccinees with HBsAb >= 10 IU/l (hazard ratio 0.51; 95% CI 0.3-1.0). In participants with initial HBsAb less than 10 IU/l, 16 of 46 (35%) infections were chronic, compared with none of 11 in those with initial HBsAb at least 10 IU/l (P = 0.02).
Conclusion: Overall, HBV vaccination was not associated with reduced risk of HBV infection in our cohort of HIV-infected individuals. However, the small subset of vaccinees with a positive vaccine response may have had reduced HBV infection risk, including chronic disease. Improvements in vaccine delivery and immunogenicity are needed to increase HBV vaccine effectiveness in HIV-infected patients. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
C1 [Landrum, Michael L.; Marconi, Vincent C.; Dolan, Matthew J.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Landrum, Michael L.; Hullsiek, Katherine Huppler; Ganesan, Anuradha; Weintrob, Amy C.; Crum-Cianflone, Nancy F.; O'Connell, Robert J.; Fieberg, Ann; Marconi, Vincent C.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD USA.
[Hullsiek, Katherine Huppler; Fieberg, Ann] Univ Minnesota, Minneapolis, MN USA.
[Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA.
[Weintrob, Amy C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Crum-Cianflone, Nancy F.] Naval Med Ctr, San Diego, CA USA.
[Barthel, R. Vincent] Naval Med Ctr, Portsmouth, VA USA.
[O'Connell, Robert J.] Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD USA.
[Chun, Helen M.] Naval Hlth Res Ctr, San Diego, CA USA.
RP Landrum, ML (reprint author), Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM mlandrum@idcrp.org
RI Marconi, Vincent/N-3210-2014;
OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669
FU NIAID NIH HHS [HU0001-05-2-0011]; PHS HHS [HU0001-05-2-0011]
NR 54
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U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
J9 AIDS
JI Aids
PD FEB 20
PY 2010
VL 24
IS 4
BP 545
EP 555
DI 10.1097/QAD.0b013e32832cd99e
PG 11
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 563QK
UT WOS:000275148000007
PM 19487908
ER
PT J
AU Foley, DH
Wilkerson, RC
Birney, I
Harrison, S
Christensen, J
Rueda, LM
AF Foley, Desmond H.
Wilkerson, Richard C.
Birney, Ian
Harrison, Stanley
Christensen, Jamie
Rueda, Leopoldo M.
TI MosquitoMap and the Mal-area calculator: new web tools to relate
mosquito species distribution with vector borne disease
SO INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS
LA English
DT Article
ID MALARIA TRANSMISSION
AB Background: Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk.
Results: A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC) was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap.
Conclusion: MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.
C1 [Foley, Desmond H.; Wilkerson, Richard C.; Rueda, Leopoldo M.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
[Birney, Ian; Harrison, Stanley; Christensen, Jamie] Worldview Solut Inc, Richmond, VA 23219 USA.
RP Foley, DH (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM foleydes@si.edu
RI Valle, Ruben/A-7512-2013;
OI Foley, Desmond/0000-0001-7525-4601
NR 17
TC 15
Z9 15
U1 2
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-072X
J9 INT J HEALTH GEOGR
JI Int. J. Health Geogr.
PD FEB 18
PY 2010
VL 9
AR 11
DI 10.1186/1476-072X-9-11
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 570QO
UT WOS:000275693200001
PM 20167090
ER
PT J
AU Rueda, LM
Brown, TL
Kim, HC
Chong, ST
Klein, TA
Foley, DH
Anyamba, A
Smith, M
Pak, EP
Wilkerson, RC
AF Rueda, Leopoldo M.
Brown, Tracy L.
Kim, Heung Chul
Chong, Sung-Tae
Klein, Terry A.
Foley, Desmond H.
Anyamba, Assaf
Smith, Matthew
Pak, Edwin P.
Wilkerson, Richard C.
TI Species composition, larval habitats, seasonal occurrence and
distribution of potential malaria vectors and associated species of
Anopheles (Diptera: Culicidae) from the Republic of Korea
SO MALARIA JOURNAL
LA English
DT Article
ID ECOLOGICAL CONDITIONS; SATELLITE DATA; IMAGERY; KENYA
AB Background: Larval mosquito habitats of potential malaria vectors and related species of Anopheles from three provinces (Gyeonggi, Gyeongsangbuk, Chungcheongbuk Provinces) of the Republic of Korea were surveyed in 2007. This study aimed to determine the species composition, seasonal occurrence and distributions of Anopheles mosquitoes. Satellite derived normalized difference vegetation index data (NDVI) was also used to study the seasonal abundance patterns of Anopheles mosquitoes.
Methods: Mosquito larvae from various habitats were collected using a standard larval dipper or a white plastic larval tray, placed in plastic bags, and were preserved in 100% ethyl alcohol for species identification by PCR and DNA sequencing. The habitats in the monthly larval surveys included artificial containers, ground depressions, irrigation ditches, drainage ditches, ground pools, ponds, rice paddies, stream margins, inlets and pools, swamps, and uncultivated fields. All field-collected specimens were identified to species, and relationships among habitats and locations based on species composition were determined using cluster statistical analysis.
Results: In about 10,000 specimens collected, eight species of Anopheles belonging to three groups were identified: Hyrcanus Group - Anopheles sinensis, Anopheles kleini, Anopheles belenrae, Anopheles pullus, Anopheles lesteri, Anopheles sineroides; Barbirostris Group - Anopheles koreicus; and Lindesayi Group - Anopheles lindesayi japonicus. Only An. sinensis was collected from all habitats groups, while An. kleini, An. pullus and An. sineroides were sampled from all, except artificial containers. The highest number of Anopheles larvae was found in the rice paddies (34.8%), followed by irrigation ditches (23.4%), ponds (17.0%), and stream margins, inlets and pools (12.0%). Anopheles sinensis was the dominant species, followed by An. kleini, An. pullus and An. sineroides. The monthly abundance data of the Anopheles species from three locations (Munsan, Jinbo and Hayang) were compared against NDVI and NDVI anomalies.
Conclusion: The species composition of Anopheles larvae varied in different habitats at various locations. Anopheles populations fluctuated with the seasonal dynamics of vegetation for 2007. Multi-year data of mosquito collections are required to provide a better characterization of the abundance of these insects from year to year, which can potentially provide predictive capability of their population density based on remotely sensed ecological measurements.
C1 [Rueda, Leopoldo M.; Brown, Tracy L.; Foley, Desmond H.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
[Rueda, Leopoldo M.; Brown, Tracy L.; Foley, Desmond H.; Wilkerson, Richard C.] Smithsonian Inst, Museum Support Ctr, WRAIR, Walter Reed Biosystemat Unit, Suitland, MD 20746 USA.
[Kim, Heung Chul; Chong, Sung-Tae] Unit 15247, APO, AP 96205 USA.
[Klein, Terry A.] Unit 15281, USAMEDDAC Korea, APO, AP 96205 USA.
[Anyamba, Assaf; Smith, Matthew; Pak, Edwin P.] NASA, Goddard Space Flight Ctr, Biospher Sci Branch, Greenbelt, MD 20771 USA.
RP Rueda, LM (reprint author), Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
EM ruedapol@si.edu
RI Valle, Ruben/A-7512-2013;
OI Foley, Desmond/0000-0001-7525-4601
FU Center for Health Promotion and Preventive Medicine; Global Emerging
Infections Surveillance and Response Systems, Silver Spring, MD; Walter
Reed Army Institute of Research; Smithsonian Institution
FX Thanks go to A. Driskell and G. Harrison (Laboratory of Analytical
Biology, Smithsonian Institution) for conducting PCR/sequencing of some
mosquito samples; personnel of the 5th Medical Detachment, and staff of
65th Medical Brigade, U. S. Army, ROK, for field collections
of mosquito specimens; and J. Pecor and WRBU staff for curatorial help.
Special thanks go to D. J. Brambilla (Research Triangle Institute,
Research Triangle Park, NC) for statistical analysis; and G. Bieler
(RTP, NC), C. Lim (WRAIR) and V. Sherwood (WRAIR) for statistical and
related support. We are grateful to F. Ruiz, C. R. Summers and B. P.
Rueda for helpful reviews of the manuscript. Funding for this work was
provided by the Center for Health Promotion and Preventive Medicine,
Global Emerging Infections Surveillance and Response Systems, Silver
Spring, MD. This research was performed under a Memorandum of
Understanding between the Walter Reed Army Institute of Research and the
Smithsonian Institution, with institutional support provided by both
organizations. The opinions and assertions contained herein are those of
the authors and are not to be construed as official or reflecting the
views of the Department of the Army or the Department of Defense.
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U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD FEB 17
PY 2010
VL 9
AR 55
DI 10.1186/1475-2875-9-55
PG 11
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 567RI
UT WOS:000275463900002
PM 20163728
ER
PT J
AU Wolf, MC
Freiberg, AN
Zhang, TH
Akyol-Ataman, Z
Grock, A
Hong, PW
Li, JR
Watson, NF
Fang, AQ
Aguilar, HC
Porotto, M
Honko, AN
Damoiseaux, R
Miller, JP
Woodson, SE
Chantasirivisal, S
Fontanes, V
Negrete, OA
Krogstad, P
Dasgupta, A
Moscona, A
Hensley, LE
Whelan, SP
Faull, KF
Holbrook, MR
Jung, ME
Lee, B
AF Wolf, Mike C.
Freiberg, Alexander N.
Zhang, Tinghu
Akyol-Ataman, Zeynep
Grock, Andrew
Hong, Patrick W.
Li, Jianrong
Watson, Natalya F.
Fang, Angela Q.
Aguilar, Hector C.
Porotto, Matteo
Honko, Anna N.
Damoiseaux, Robert
Miller, John P.
Woodson, Sara E.
Chantasirivisal, Steven
Fontanes, Vanessa
Negrete, Oscar A.
Krogstad, Paul
Dasgupta, Asim
Moscona, Anne
Hensley, Lisa E.
Whelan, Sean P.
Faull, Kym F.
Holbrook, Michael R.
Jung, Michael E.
Lee, Benhur
TI A broad-spectrum antiviral targeting entry of enveloped viruses
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE virology; viral entry; fusion inhibitor; small molecule; lipid membrane
ID PLASMA-MEMBRANE; NIPAH-VIRUS; IN-VITRO; CELL-FUSION; MECHANISMS;
PEPTIDE; LYSOPHOSPHATIDYLCHOLINE; PARAMYXOVIRUS; GLYCOPROTEINS;
CURVATURE
AB We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp contrast, the compound had no effect on the infection of nonenveloped viruses. In vitro and in vivo assays showed no overt toxicity. LJ001 specifically intercalated into viral membranes, irreversibly inactivated virions while leaving functionally intact envelope proteins, and inhibited viral entry at a step after virus binding but before virus-cell fusion. LJ001 pretreatment also prevented virus-induced mortality from Ebola and Rift Valley fever viruses. Structure-activity relationship analyses of LJ001, a rhodanine derivative, implicated both the polar and nonpolar ends of LJ001 in its antiviral activity. LJ001 specifically inhibited virus-cell but not cell-cell fusion, and further studies with lipid biosynthesis inhibitors indicated that LJ001 exploits the therapeutic window that exists between static viral membranes and biogenic cellular membranes with reparative capacity. In sum, our data reveal a class of broad-spectrum antivirals effective against enveloped viruses that target the viral lipid membrane and compromises its ability to mediate virus-cell fusion.
C1 [Wolf, Mike C.; Akyol-Ataman, Zeynep; Grock, Andrew; Hong, Patrick W.; Watson, Natalya F.; Fang, Angela Q.; Aguilar, Hector C.; Chantasirivisal, Steven; Fontanes, Vanessa; Negrete, Oscar A.; Dasgupta, Asim; Lee, Benhur] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90025 USA.
[Zhang, Tinghu; Faull, Kym F.; Jung, Michael E.] Univ Calif Los Angeles, Dept Chem, Los Angeles, CA 90025 USA.
[Miller, John P.; Krogstad, Paul] Univ Calif Los Angeles, Dept Med & Mol Pharmacol, Los Angeles, CA 90025 USA.
[Lee, Benhur] Univ Calif Los Angeles, Dept Pathol, Los Angeles, CA 90025 USA.
[Lee, Benhur] Univ Calif Los Angeles, Los Angeles AIDS Inst, Los Angeles, CA 90025 USA.
[Freiberg, Alexander N.; Woodson, Sara E.; Holbrook, Michael R.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA.
[Li, Jianrong; Whelan, Sean P.] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA.
[Honko, Anna N.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Porotto, Matteo; Moscona, Anne] Cornell Univ, Weill Med Coll, New York, NY 10021 USA.
RP Lee, B (reprint author), Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90025 USA.
EM bleebhl@ucla.edu
RI Damoiseaux, Robert/F-1086-2011; Li, Jianrong/E-3510-2011; Lee,
Benhur/A-8554-2016;
OI Damoiseaux, Robert/0000-0002-7611-7534; Lee, Benhur/0000-0003-0760-1709;
Honko, Anna/0000-0001-9165-148X
FU National Institutes of Health [AI065359, AI069317, AI070495, AI082100];
UCLA Center for Aids Research [AI028697]; Burroughs Wellcome Fund; March
of Dimes; California NanoSystems Institute; UCLA Microbial Pathogenesis
[AI07323]; Warsaw Fellowship Endowment; Rheumatology Training Grant
[AR053463]
FX We thank D. Nayak and S. Barman for Influenza A testing, T. S. Dermody
for Reovirus T3D, Peter Palese for rNDV-GFP, and K. Esham and J.C.
Johnson (US Army Medical Research Institute of Infectious Diseases) for
BSL-4 assistance. We also thank I.S.Y. Chen, R. W. Doms, and K. A.
Bradley for thoughtful discussion and members of the Lee laboratory, and
especially F. Vigant, for both thoughtful conversation and review of the
manuscript. This work was supported by National Institutes of Health
Grants AI065359, AI069317, AI070495, and AI082100 (to B. L.), UCLA
Center for Aids Research Grant AI028697, the Burroughs Wellcome Fund (B.
L., S. P. W.), a March of Dimes Research Grant (to A. M.), the
California NanoSystems Institute (R. D.), UCLA Microbial Pathogenesis
Training Grant AI07323, a Warsaw Fellowship Endowment (M. C. W.), and
Rheumatology Training Grant AR053463 (to P. W. H.).
NR 33
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PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD FEB 16
PY 2010
VL 107
IS 7
BP 3157
EP 3162
DI 10.1073/pnas.0909587107
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 556OC
UT WOS:000274599500081
PM 20133606
ER
PT J
AU Moawad, FJ
Veerappan, GR
Lake, JM
Maydonovitch, CL
Haymore, BR
Kosisky, SE
Wong, RKH
AF Moawad, F. J.
Veerappan, G. R.
Lake, J. M.
Maydonovitch, C. L.
Haymore, B. R.
Kosisky, S. E.
Wong, R. K. H.
TI Correlation between eosinophilic oesophagitis and aeroallergens
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID SKIN PRICK; FOOD ALLERGY; PATCH TESTS; CHILDREN; PATHOGENESIS;
DIAGNOSIS; MUCOSA; POLLEN; ADULTS; DIET
AB Background
Aeroallergens have been implicated in the pathogenesis of eosinophilic oesophagitis.
Aim
To determine whether a seasonal variation exists in the diagnoses of eosinophilic oesophagitis and whether there is a correlation with seasonal pollen count.
Methods
A retrospective review was performed from January 2006 to November 2008 to identify eosinophilic oesophagitis patients. Cases were classified by endoscopic date. Daily pollen counts for grass, trees and weeds were obtained from a certified counting station. Per cent of eosinophilic oesophagitis cases were collated seasonally and compared with mean pollen counts for grass, trees and weeds during the same time period.
Results
A total of 127 eosinophilic oesophagitis cases were identified (median age 41, range 19-92 years, 84% men). The highest percentage of cases (33.0%; Binomial P = 0.022) was diagnosed in the spring, while the least percentage (16%; Binomial P = 0.0.010) occurred in the winter. There was a significant association between per cent eosinophilic oesophagitis cases diagnosed seasonally and mean grass pollen count (rs = 1.000, P < 0.01), but not with trees (rs = 0.400, P = 0.600) or weeds (rs = 0.800, P = 0.200).
Conclusions
A seasonal variation was seen in the diagnosis of eosinophilic oesophagitis which correlated with pollen counts. These findings have important implications regarding the pathogenesis of eosinophilic oesophagitis, suggesting a potential role for aeroallergens.
C1 [Moawad, F. J.; Veerappan, G. R.; Lake, J. M.; Maydonovitch, C. L.; Wong, R. K. H.] Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, Washington, DC 20307 USA.
[Haymore, B. R.; Kosisky, S. E.] Walter Reed Army Med Ctr, Gastroenterol Serv, Allergy & Immunol Serv, Washington, DC 20307 USA.
RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Gastroenterol Serv, Dept Med, 6900 Georgia Ave, Washington, DC 20307 USA.
EM fouad.moawad@amedd.army.mil
NR 26
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U1 0
U2 2
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0269-2813
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD FEB 15
PY 2010
VL 31
IS 4
BP 509
EP 515
DI 10.1111/j.1365-2036.2009.04199.x
PG 7
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 543SF
UT WOS:000273598000006
PM 19925501
ER
PT J
AU Milner, E
McCalmont, W
Bhonsle, J
Caridha, D
Carroll, D
Gardner, S
Gerena, L
Gettayacamin, M
Lanteri, C
Luong, T
Melendez, V
Moon, J
Roncal, N
Sousa, J
Tungtaeng, A
Wipf, P
Dow, G
AF Milner, Erin
McCalmont, William
Bhonsle, Jayendra
Caridha, Diana
Carroll, Dustin
Gardner, Sean
Gerena, Lucia
Gettayacamin, Montip
Lanteri, Charlotte
Luong, ThuLan
Melendez, Victor
Moon, Jay
Roncal, Norma
Sousa, Jason
Tungtaeng, Anchalee
Wipf, Peter
Dow, Geoffrey
TI Structure-activity relationships amongst 4-position quinoline methanol
antimalarials that inhibit the growth of drug sensitive and resistant
strains of Plasmodium falciparum
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Antimalarials; Plasmodium falciparum; Plasmodium berghei; Mefloquine;
Quinoline methanol; Structure-activity relationship
ID P-GLYCOPROTEIN; MEFLOQUINE; MALARIA
AB Utilizing mefloquine as a scaffold, a next generation quinoline methanol (NGQM) library was constructed to identify early lead compounds that possess biological properties consistent with the target product pro. le for malaria chemoprophylaxis while reducing permeability across the blood-brain barrier. The library of 200 analogs resulted in compounds that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum. Herein we report selected chemotypes and the emerging structure activity relationship for this library of quinoline methanols. Published by Elsevier Ltd.
C1 [Milner, Erin; McCalmont, William; Bhonsle, Jayendra; Caridha, Diana; Carroll, Dustin; Gardner, Sean; Gerena, Lucia; Lanteri, Charlotte; Luong, ThuLan; Melendez, Victor; Moon, Jay; Roncal, Norma; Sousa, Jason; Dow, Geoffrey] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Gettayacamin, Montip; Tungtaeng, Anchalee] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand.
[Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA.
RP Milner, E (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA.
EM erin.milner@us.army.mil
RI Sousa, Jason/A-9177-2011; Luong, Thu-Lan/A-9160-2011
FU Military Infectious Diseases Research Program (MIDRP)
FX We thank the - for financial support.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD FEB 15
PY 2010
VL 20
IS 4
BP 1347
EP 1351
DI 10.1016/j.bmcl.2010.01.001
PG 5
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA 552JJ
UT WOS:000274285600006
PM 20097070
ER
PT J
AU Lee, J
Feng, X
Faiia, AM
Posmentier, ES
Kirchner, JW
Osterhuber, R
Taylor, S
AF Lee, Jeonghoon
Feng, Xiahong
Faiia, Anthony M.
Posmentier, Eric S.
Kirchner, James W.
Osterhuber, Randall
Taylor, Susan
TI Isotopic evolution of a seasonal snowcover and its melt by isotopic
exchange between liquid water and ice
SO CHEMICAL GEOLOGY
LA English
DT Article
DE Snowmelt; Isotopic exchange between liquid and ice; Isotopic
heterogeneity of a snowpack
ID ONE-DIMENSIONAL MODEL; STABLE-ISOTOPES; HYDROGRAPH SEPARATION;
FRACTIONATION; SNOWPACK; SNOWMELT; PRECIPITATION; DELTA-O-18;
EVAPORATION; STREAMFLOW
AB Understanding an isotopic evolution of a snowpack is important for both climate and hydrological studies, because the snowmelt is a significant component of groundwater and surface runoff in temperate areas. In this work, we studied oxygen and hydrogen isotopic evolution from new snow to snow profile and to meltwater through two winter seasons (1998 and 2001) at the Central Sierra Snow Laboratory, California, USA. The slopes of the delta D vs. delta(18)O regression for the new snow are similar to that of the global meteoric water line (GMWL) of 8. However, this slope decreases in the snow profile and decreases further in the meltwater. We attribute this systematic slope changes to the isotopic exchange between ice and liquid water that is generated at the snow surface by melting and flows through the snowpack by percolation. A physically-based one-dimensional model, including melting of snow at the surface and isotopic exchange between percolating water and ice, was used to simulate isotopic variation of snowmelt in 2001. A successful simulation was obtained for the delta D-delta(18)O slope of snowmelt (6.5), which is significantly lower than the slope of the meteoric water line (8.2) defined by the new snow. This result indicates that the liquid water evaporation should not be considered as the only process that yields slopes of the delta D vs. delta(18)O relationship in surface water and groundwater. The d-excess of the snowmelt is changed from the original snow because of the delta D-delta(18)O relationship controlled by ice-liquid exchange. With a delta D-delta(18)O slope less than 8, the d-excess would be anti-correlated with delta D or delta(18)O. The model is also used to examine how isotopic heterogeneity of a snowpack affects the isotopic redistribution in the pore water, ice and meltwater of the snowpack. The results show that isotopic heterogeneity of the snowpack may significantly affect the temporal changes in the delta D-delta(18)O slopes, and a measured slope at a given time is a combined result of meteorological conditions, which affect both isotopic composition of the original snow and the process of snow metamorphism, and the melting history of the snowpack. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Lee, Jeonghoon; Feng, Xiahong; Faiia, Anthony M.; Posmentier, Eric S.] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA.
[Kirchner, James W.] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA.
[Kirchner, James W.] Swiss Fed Inst Forest Snow & Landscape Res WSL, CH-8903 Birmensdorf, Switzerland.
[Kirchner, James W.] Swiss Fed Inst Technol, CH-8092 Zurich, Switzerland.
[Osterhuber, Randall] Cent Sierra Snow Lab, Soda Springs, CA 95728 USA.
[Taylor, Susan] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Lee, J (reprint author), Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA.
EM jeonghoon.lee@jpl.nasa.gov
RI Lee, Jeonghoon/E-8116-2010; Kirchner, James/B-6126-2009
OI Lee, Jeonghoon/0000-0002-1256-4431; Kirchner, James/0000-0001-6577-3619
FU National Science Foundation [EAR-9903281, EAR-0111403, EAR-0418809];
Dartmouth College
FX This research was partially supported by the National Science Foundation
(EAR-9903281, EAR-0111403, and EAR-0418809) and by Dartmouth College.
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-2541
J9 CHEM GEOL
JI Chem. Geol.
PD FEB 15
PY 2010
VL 270
IS 1-4
BP 126
EP 134
DI 10.1016/j.chemgeo.2009.11.011
PG 9
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 561PH
UT WOS:000274989800012
ER
PT J
AU Liu, G
Talley, JW
Na, CZ
Larson, SL
Wolfe, LG
AF Liu, Guojing
Talley, Jeffrey W.
Na, Chongzheng
Larson, Steve L.
Wolfe, Lawrence G.
TI Copper Doping Improves Hydroxyapatite Sorption for Arsenate in Simulated
Groundwaters
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID INORGANIC CATION-EXCHANGERS; ZERO-VALENT IRON; SYNTHETIC
HYDROXYAPATITES; AQUEOUS-SOLUTIONS; ARSENITE REMOVAL; MINERAL APATITE;
IONS; REMEDIATION; IMMOBILIZATION; ADSORPTION
AB Hydroxyapatite (HAP) has been widely used to immobilize many cationic heavy metals in water and soils. Compared with its strong sorption for metal cations, the abilities of HAP to sorb metal anions, such as arsenic, are less significant. Improving HAP sorption for anionic arsenic species is important for expanding its application potential because the presence of arsenic in the environment has raised serious health concerns and there is need for cost-effective remediation methods. In this work, we report an innovative method of copper doping to improve a synthetic HAP sorption for arsenate, which is a primary aqueous arsenic species, in simulated groundwaters. The undoped HAP and copper doped HAP (CuHAP) were characterized with XRD, FTIR, N(2) adsorption, and SEM, and then evaluated as sorbents for arsenate removal tests. The experimental results suggest that copper doping changed the morphology and increased the surface area of HAP. The CuHAP sorbed 1.6-9.1 x more arsenate than the undoped HAP did in a simulated groundwater at pH of 7.7-8.0. The improved arsenate sorption is presumably due to the increase in surface area of HAP as a result of copper doping. In addition to the copper doping level, the arsenate sorption to HAP and CuHAP can also be increased with increasing water pH and calcium concentration. The experimental data indicate that sorbent dissolution is an important factor governing arsenate sorption to HAP and CuHAP.
C1 Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA.
Dept Environm & Civil Engn, Dallas, TX 75205 USA.
[Larson, Steve L.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Liu, G (reprint author), Univ Notre Dame, Notre Dame, IN 46556 USA.
EM liuguojing@gmail.com; jtalley@lyle.smu.edu
FU University of Notre Dame Faculty Scholarship Award Program
FX We thank the Center of Environmental Science and Technology (CEST), the
Environmental Molecular Scientific Institute (EMS]), and the
Environmental Mineralogy and Crystal Structures Lab at the University of
Notre Dame for providing the necessary instrumentation for this study.
C.N. thanks the generous support by the University of Notre Dame Faculty
Scholarship Award Program.
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 15
PY 2010
VL 44
IS 4
BP 1366
EP 1372
DI 10.1021/es9015734
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 553EC
UT WOS:000274347800034
PM 20095528
ER
PT J
AU Vahey, MT
Wang, ZN
Kester, KE
Cummings, J
Heppner, DG
Nau, ME
Ofori-Anyinam, O
Cohen, J
Coche, T
Ballou, WR
Ockenhouse, CF
AF Vahey, Maryanne T.
Wang, Zhining
Kester, Kent E.
Cummings, James
Heppner, D. Gray, Jr.
Nau, Martin E.
Ofori-Anyinam, Opokua
Cohen, Joe
Coche, Thierry
Ballou, W. Ripley
Ockenhouse, Christian F.
TI Expression of Genes Associated with Immunoproteasome Processing of Major
Histocompatibility Complex Peptides Is Indicative of Protection with
Adjuvanted RTS,S Malaria Vaccine
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID FALCIPARUM CIRCUMSPOROZOITE-PROTEIN; INSTITUTE-OF-RESEARCH; YELLOW-FEVER
VACCINE; PHASE 2A TRIAL; PLASMODIUM-FALCIPARUM; BREAST-CANCER; NAIVE
ADULTS; ANTIGEN PRESENTATION; IMMUNE-RESPONSES; RHESUS MACAQUES
AB Background. Patterns of expressed genes in the peripheral blood mononuclear cells of persons who were receiving RTS,S/AS01 or RTS,S/AS02 malaria vaccine and were undergoing experimental challenge with mosquito-borne falciparum malaria were examined to identify markers associated with protection.
Methods. Thirty-nine vaccine recipients were assessed at study entry; on the day of the third vaccination; at 24 h, 72 h, and 2 weeks after vaccination; and on day 5 after challenge. Of 39 vaccine recipients, 13 were protected and 26 were not. Eleven vaccine recipients exhibited delayed onset of parasitemia. All infectivity control subjects developed parasitemia. Prediction analysis of microarrays identified genes corresponding with protection. Gene set enrichment analysis identified sets of genes associated with protection after the third vaccination and before challenge.
Results. After the third vaccination and before challenge, differential expression of genes in the immunoproteasome pathway distinguished protected and nonprotected persons. At 5 days after challenge, differential expression of genes associated with programmed cell death distinguished between subjects protected and not protected from malaria blood-stage infection.
Conclusions. The up-regulation of genes associated with the efficient processing of major histocompatibility complex peptides suggests a potential role of the vaccine in conferring major histocompatibility complex class 1 mediated protection and may represent a useful surrogate marker of vaccine efficacy without the need for challenge.
C1 [Vahey, Maryanne T.; Kester, Kent E.; Cummings, James; Heppner, D. Gray, Jr.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Silver Spring, MD 20403 USA.
[Wang, Zhining; Nau, Martin E.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA.
[Ballou, W. Ripley] Bill & Melinda Gates Fdn, Seattle, WA USA.
[Ofori-Anyinam, Opokua; Cohen, Joe; Coche, Thierry] GlaxoSmithKline Biol, Rixensart, Belgium.
RP Vahey, MT (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20403 USA.
EM maryanne.vahey@us.army.mil
RI Kester, Kent/A-2114-2011
OI Kester, Kent/0000-0002-5056-0802
NR 38
TC 39
Z9 39
U1 0
U2 2
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD FEB 15
PY 2010
VL 201
IS 4
BP 580
EP 589
DI 10.1086/650310
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 546WF
UT WOS:000273843900015
PM 20078211
ER
PT J
AU Kibuuka, H
Kimutai, R
Maboko, L
Sawe, F
Schunk, MS
Kroidl, A
Shaffer, D
Eller, LA
Kibaya, R
Eller, MA
Schindler, KB
Schuetz, A
Millard, M
Kroll, J
Dally, L
Hoelscher, M
Bailer, R
Cox, JH
Marovich, M
Birx, DL
Graham, BS
Michael, NL
de Souza, MS
Robb, ML
AF Kibuuka, Hannah
Kimutai, Robert
Maboko, Leonard
Sawe, Fred
Schunk, Mirjam S.
Kroidl, Arne
Shaffer, Douglas
Eller, Leigh Anne
Kibaya, Rukia
Eller, Michael A.
Schindler, Karin B.
Schuetz, Alexandra
Millard, Monica
Kroll, Jason
Dally, Len
Hoelscher, Michael
Bailer, Robert
Cox, Josephine H.
Marovich, Mary
Birx, Deborah L.
Graham, Barney S.
Michael, Nelson L.
de Souza, Mark S.
Robb, Merlin L.
TI A Phase 1/2 Study of a Multiclade HIV-1 DNA Plasmid Prime and
Recombinant Adenovirus Serotype 5 Boost Vaccine in HIV-Uninfected East
Africans (RV 172)
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID IMMUNODEFICIENCY VIRUS CHALLENGE; MEMORY T-CELLS; CANDIDATE VACCINE;
AIDS VACCINE; DOUBLE-BLIND; INFECTION; TRIAL; SURVIVAL; IMMUNITY;
MONKEYS
AB Background. Human immunodeficiency virus (HIV) vaccine development remains a global priority. We describe the safety and immunogenicity of a multiclade DNA vaccine prime with a replication-defective recombinant adenovirus serotype 5 (rAd5) boost.
Methods. The vaccine is a 6-plasmid mixture encoding HIV envelope (env) subtypes A, B, and C and subtype B gag, pol, and nef, and an rAd5 expressing identical genes, with the exception of nef. Three hundred and twenty-four participants were randomized to receive placebo (n = 138), a single dose of rAd5 at 10(10) (n = 24) or 10(11) particle units (n = 24), or DNA at 0, 1, and 2 months, followed by rAd5 at either 10(10) (n = 114) or 10(11) particle units (n = 24) boosting at 6 months. Participants were followed up for 24 weeks after the final vaccination.
Results. The vaccine was safe and well tolerated. HIV-specific T cell responses were detected in 63% of vaccinees. Titers of preexisting Ad5 neutralizing antibody did not affect the frequency and magnitude of T cell responses in prime-boost recipients but did affect the response rates in participants that received rAd5 alone (P = .037).
Conclusion. The DNA/rAd5 vaccination regimen was safe and induced HIV type 1 multi-clade T cell responses, which were not significantly affected by titers of preexisting rAd5 neutralizing antibody.
C1 [Kibuuka, Hannah; Eller, Leigh Anne; Eller, Michael A.; Millard, Monica] Makerere Univ, Walter Reed Project, Kampala, Uganda.
[Kimutai, Robert; Sawe, Fred; Shaffer, Douglas; Kibaya, Rukia] US Army Med Res Unit Kenya, Walter Reed Project, Kericho, Kenya.
[Maboko, Leonard; Schunk, Mirjam S.; Kroidl, Arne; Schindler, Karin B.; Schuetz, Alexandra; Hoelscher, Michael] Mbeya Med Res Programme, Mbeya, Tanzania.
[Schunk, Mirjam S.; Kroidl, Arne; Schindler, Karin B.; Schuetz, Alexandra; Hoelscher, Michael] Klinikum Ludwigs Maximilians Univ, Munich, Germany.
[Eller, Leigh Anne; Eller, Michael A.; Marovich, Mary; Michael, Nelson L.; de Souza, Mark S.; Robb, Merlin L.] US Mil, HIV Res Program, Rockville, MD USA.
[Kroll, Jason; Dally, Len] Emmes Corp, Rockville, MD USA.
[Bailer, Robert; Graham, Barney S.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Cox, Josephine H.] Int AIDS Vaccine Initiat, New York, NY USA.
[Birx, Deborah L.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[de Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
RP Robb, ML (reprint author), 1600 Gude Dr, Rockville, MD 20850 USA.
EM mrobb@hivresearch.org
RI Hoelscher, Michael/D-3436-2012
FU NIAID NIH HHS [Y01 AI2642-12]
NR 24
TC 70
Z9 71
U1 0
U2 3
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD FEB 15
PY 2010
VL 201
IS 4
BP 600
EP 607
DI 10.1086/650299
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 546WF
UT WOS:000273843900017
PM 20078213
ER
PT J
AU Zhang, SS
Foster, D
Read, J
AF Zhang, Sheng S.
Foster, Donald
Read, Jeffrey
TI Discharge characteristic of a non-aqueous electrolyte Li/O-2 battery
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Metal/air battery; Li/air battery; Air electrode; Oxygen reduction;
Non-aqueous electrolyte
ID ORGANIC ELECTROLYTE; LITHIUM/OXYGEN BATTERY; ALKALINE-SOLUTION; OXYGEN
REDUCTION; ACTIVATED CARBON; AIR BATTERIES; CATHODES
AB Discharge characteristic of Li/O-2 cells was studied using galvanostatic discharge, polarization. and ac-impedance techniques. Results show that the discharge performance of Li/O-2 cells is determined mainly by the carbon air electrode, instead by the Li anode. A consecutive polarization experiment shows that impedance of the air electrode is progressively increased with polarization cycle number since the surfaces of the air electrode are gradually covered by discharge products, which prevents oxygen from diffusing to the reaction sites of carbon. Based on this observation, we proposed an electrolyte-catalyst "two-phase reaction zone" model for the catalytic reduction of oxygen in carbon air electrode. According to this model, the best case for electrolyte-filling is that the air electrode is completely wetted while still remaining sufficient pores for fast diffusion of gaseous oxygen. it is shown that an electrolyte-flooded cell suffers low specific capacity and poor power performance due to slow diffusion of the dissolved oxygen in liquid electrolyte. Therefore, the status of electrolyte-filling plays an essential role in determining the specific capacity and power capability of a Li/O-2 cell. In addition, we found that at low discharge currents the Li/O-2 cell showed two discharge voltage plateaus. The second voltage plateau is attributed to a continuous discharge of Li/O-2 into Li2O, and this discharge shows high polarization due to the electrically isolating property of Li2O2. Published by Elsevier B.V.
C1 [Zhang, Sheng S.; Foster, Donald; Read, Jeffrey] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
RP Zhang, SS (reprint author), USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
EM szhang@arl.army.mil
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
NR 14
TC 219
Z9 223
U1 15
U2 185
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD FEB 15
PY 2010
VL 195
IS 4
SI SI
BP 1235
EP 1240
DI 10.1016/j.jpowsour.2009.08.088
PG 6
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 519PK
UT WOS:000271779100047
ER
PT J
AU Bansal, NP
Zhu, DM
AF Bansal, Narottam P.
Zhu, Dongming
TI Effects of doping on thermal conductivity of pyrochlore oxides for
advanced thermal barrier coatings (vol 459, pg 192, 2007)
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Correction
C1 [Bansal, Narottam P.] NASA, Glenn Res Ctr, Mat & Struct Div, Cleveland, OH 44135 USA.
[Zhu, Dongming] NASA, Glenn Res Ctr, Vehicle Technol Directorate, US Army Res Lab, Cleveland, OH 44135 USA.
RP Bansal, NP (reprint author), NASA, Glenn Res Ctr, Mat & Struct Div, 21000 Brookpk Rd,Mail Stop 106-5, Cleveland, OH 44135 USA.
EM Narottam.P.Bansal@nasa.gov
NR 1
TC 0
Z9 0
U1 1
U2 10
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD FEB 15
PY 2010
VL 527
IS 4-5
BP 1281
EP 1281
DI 10.1016/j.msea.2009.08.030
PG 1
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA 548RM
UT WOS:000273983900063
ER
PT J
AU Hu, SW
Olulade, O
Castillo, JG
Santos, J
Kim, S
Tamer, GG
Luh, WM
Talavage, TM
AF Hu, Shuowen
Olulade, Olumide
Castillo, Javier Gonzalez
Santos, Joseph
Kim, Sungeun
Tamer, Gregory G., Jr.
Luh, Wen-Ming
Talavage, Thomas M.
TI Modeling hemodynamic responses in auditory cortex at 1.5 T using
variable duration imaging acoustic noise
SO NEUROIMAGE
LA English
DT Article
DE Imaging acoustic noise; Functional MRI; Hemodynamic response; Linear
systems
ID EVENT-RELATED FMRI; FUNCTIONAL MRI; SCANNER NOISE; BOLD RESPONSE;
NONLINEARITY; INSULA; SYSTEM
AB A confound for functional magnetic resonance imaging (fMRI), especially for auditory studies, is the presence of imaging acoustic noise generated mainly as a byproduct of rapid gradient switching during volume acquisition and, to a lesser extent, the radiofrequency transmit. This work utilized a novel pulse sequence to present actual imaging acoustic noise for characterization of the induced hemodynamic responses and assessment of linearity in the primary auditory cortex with respect to noise duration. Results show that responses to brief duration (46 ms) imaging acoustic noise is highly nonlinear while responses to longer duration (>1 s) imaging acoustic noise becomes approximately linear, with the right primary auditory cortex exhibiting a higher degree of nonlinearity than the left for the investigated noise durations. This study also assessed the spatial extent ofactivation induced by imaging acoustic noise, showing that the use of modeled responses (specific to imaging acoustic noise) as the reference waveform revealed additional activations in the auditory cortex not observed with a canonical gamma variate reference waveform, suggesting an improvement in detection sensitivity for imaging acoustic noise-induced activity. Longer duration (1.5 s) imaging acoustic noise was observed to induce activity that expanded outwards from Heschl's gyrus to cover the superior temporal gyrus as well as parts of the middle temporal gyrus and insula, potentially affecting higher level acoustic processing. Published by Elsevier Inc.
C1 [Hu, Shuowen; Olulade, Olumide; Kim, Sungeun; Talavage, Thomas M.] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA.
[Hu, Shuowen] USA, Res Lab, Adelphi, MD USA.
[Castillo, Javier Gonzalez; Santos, Joseph; Tamer, Gregory G., Jr.; Talavage, Thomas M.] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA.
[Luh, Wen-Ming] NIMH, NIH, Bethesda, MD 20892 USA.
RP Hu, SW (reprint author), 465 NW Ave, W Lafayette, IN 47906 USA.
EM hu@ecn.purdue.edu
RI Gonzalez-Castillo, Javier/B-6903-2012;
OI Gonzalez-Castillo, Javier/0000-0002-6520-5125
FU NIH [R01EB003990]; National Institute of Mental Health
FX This research was supported in part by NIH grant R01EB003990 and the
Intramural Research Program of the National Institute of Mental Health.
NR 41
TC 9
Z9 9
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
J9 NEUROIMAGE
JI Neuroimage
PD FEB 15
PY 2010
VL 49
IS 4
BP 3027
EP 3038
DI 10.1016/j.neuroimage.2009.11.051
PG 12
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 549OW
UT WOS:000274064500015
PM 19948232
ER
PT J
AU Milner, E
McCalmont, W
Bhonsle, J
Caridha, D
Cobar, J
Gardner, S
Gerena, L
Goodine, D
Lanteri, C
Melendez, V
Roncal, N
Sousa, J
Wipf, P
Dow, GS
AF Milner, Erin
McCalmont, William
Bhonsle, Jayendra
Caridha, Diana
Cobar, Jose
Gardner, Sean
Gerena, Lucia
Goodine, Duane
Lanteri, Charlotte
Melendez, Victor
Roncal, Norma
Sousa, Jason
Wipf, Peter
Dow, Geoffrey Stuart
TI Anti-malarial activity of a non-piperidine library of next-generation
quinoline methanols
SO MALARIA JOURNAL
LA English
DT Article
ID BLOOD-BRAIN-BARRIER; MEFLOQUINE; PERMEABILITY; DRUGS; RESISTANCE;
TRANSPORT; BILAYERS; CNS
AB Background: The clinical utility for mefloquine has been eroded due to its association with adverse neurological effects. Better-tolerated alternatives are required. The objective of the present study was the identification of lead compounds that are as effective as mefloquine, but exhibit physiochemical properties likely to render them less susceptible to passage across the blood-brain barrier.
Methods: A library of drug-like non-piperidine analogs of mefloquine was synthesized. These compounds are diverse in structure and physiochemical properties. They were screened in appropriate in vitro assays and evaluated in terms of their potential as lead compounds. The correlation of specific structural attributes and physiochemical properties with activity was assessed.
Results: The most potent analogs were low molecular weight unconjugated secondary amines with no heteroatoms in their side-chains. However, these compounds were more metabolically labile and permeable than mefloquine. In terms of physiochemical properties, lower polar surface area, lower molecular weight, more freely rotatable bonds and fewer H-bond acceptors were associated with greater potency. There was no such relationship between activity and LogP, LogD or the number of hydrogen bond donors (HBDs). The addition of an H-bond donor to the side-chain yielded a series of active diamines, which were as metabolically stable as mefloquine but showed reduced permeability.
Conclusions: A drug-like library of non-piperidine analogs of mefloquine was synthesized. From amongst this library an active lead series of less permeable, but metabolically stable, diamines was identified.
C1 [Milner, Erin; McCalmont, William; Bhonsle, Jayendra; Caridha, Diana; Cobar, Jose; Gardner, Sean; Gerena, Lucia; Goodine, Duane; Lanteri, Charlotte; Melendez, Victor; Roncal, Norma; Sousa, Jason; Dow, Geoffrey Stuart] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
[Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA.
RP Milner, E (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
EM erin.milner@amedd.army.mil
RI Sousa, Jason/A-9177-2011
FU Absorption Systems (Exton PA)
FX The MDCK permeability assays were performed under contract by Absorption
Systems (Exton PA). The A2A and A1 screens were conducted by Caliper
Biosciences (Hanover, MD).
NR 22
TC 21
Z9 21
U1 0
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD FEB 11
PY 2010
VL 9
AR 51
DI 10.1186/1475-2875-9-51
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 567RE
UT WOS:000275463500005
PM 20149249
ER
PT J
AU Hu, SW
Young, SS
Hong, T
Reynolds, JP
Krapels, K
Miller, B
Thomas, J
Nguyen, O
AF Hu, Shuowen
Young, S. Susan
Hong, Tsai
Reynolds, Joseph P.
Krapels, Keith
Miller, Brian
Thomas, Jim
Nguyen, Oanh
TI Super-resolution for flash ladar imagery
SO APPLIED OPTICS
LA English
DT Article
AB Flash ladar systems are compact devices with high frame rates that hold promise for robotics applications, but these devices suffer from poor spatial resolution. This work develops a wavelet preprocessing stage to enhance registration of multiple frames and applies super-resolution to improve the resolution of flash ladar range imagery. The triangle orientation discrimination methodology was used for a subjective evaluation of the effectiveness of super-resolution for flash ladar. Results show statistically significant increases in the probability of target discrimination at all target ranges, as well as a reduction in subject response times for super-resolved imagery. (C) 2010 Optical Society of America
C1 [Hu, Shuowen; Young, S. Susan] Army Res Lab, Adelphi, MD 20783 USA.
[Hong, Tsai] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA.
[Reynolds, Joseph P.; Krapels, Keith; Miller, Brian; Thomas, Jim; Nguyen, Oanh] Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Hu, SW (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM shuowen.hu@arl.army.mil
NR 14
TC 9
Z9 9
U1 0
U2 4
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD FEB 10
PY 2010
VL 49
IS 5
BP 772
EP 780
DI 10.1364/AO.49.000772
PG 9
WC Optics
SC Optics
GA 554OK
UT WOS:000274444100004
PM 20154743
ER
PT J
AU Barnoy, S
Jeong, KI
Helm, RF
Suvarnapunya, AE
Ranallo, RT
Tzipori, S
Venkatesan, MM
AF Barnoy, S.
Jeong, K. I.
Helm, R. F.
Suvarnapunya, A. E.
Ranallo, R. T.
Tzipori, S.
Venkatesan, M. M.
TI Characterization of WRSs2 and WRSs3, new second-generation
virG(icsA)-based Shigella sonnei vaccine candidates with the potential
for reduced reactogenicity
SO VACCINE
LA English
DT Article
DE Shigella sonnei; Live attenuated vaccine candidates; WRSs2; WRSs3
ID COLI-MSBB GENE; ENTEROINVASIVE ESCHERICHIA-COLI; CARRYING CLASS-2
INTEGRONS; FIELD GEL-ELECTROPHORESIS; LARGE VIRULENCE PLASMID; FLEXNERI
2A; ANTIMICROBIAL RESISTANCE; ORAL VACCINE; LIPID-A; MULTICOPY
SUPPRESSOR
AB Live, attenuated Shigella vaccine candidates, such as Shigella sonnei strain WRSS1, Shigella flexneri 2a strain SC602, and Shigella dysenteriae 1 strain WRSd1, are attenuated principally by the loss of the VirG(lcsA) protein. These candidates have proven to be safe and immunogenic in volunteer trials and in one study, efficacious against shigellosis. One drawback of these candidate vaccines has been the reactogenic symptoms of fever and diarrhea experienced by the volunteers, that increased in a dose-dependent manner. New, second-generation virG(icsA)-based S. sonnei vaccine candidates. WRSs2 and WRSs3, are expected to be less reactogenic while retaining the ability to generate protective levels of immunogenicity seen with WRSS1. Besides the loss of VirG(IcsA), WRSs2 and WRSs3 also lack plasmid-encoded enterotoxin ShET2-1 and its paralog ShET2-2. WRSs3 further lacks MsbB2 that reduces the endotoxicity of the lipid A portion of the bacterial LPS. Studies in cell cultures and in gnotobiotic piglets demonstrate that WRSs2 and WRSs3 have the potential to cause less diarrhea due to loss of ShET2-1 and ShET2-2 as well as alleviate febrile symptoms by loss of MsbB2. In guinea pigs, WRSs2 and WRSs3 were as safe, immunogenic and efficacious as WRSS1. Published by Elsevier Ltd.
C1 [Barnoy, S.; Suvarnapunya, A. E.; Ranallo, R. T.; Venkatesan, M. M.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA.
[Jeong, K. I.; Tzipori, S.] Tufts Univ, Div Infect Dis, Cummings Sch Vet Med, North Grafton, MA 01536 USA.
[Helm, R. F.] Virginia Tech, Dept Biochem, Blacksburg, VA 24061 USA.
RP Venkatesan, MM (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM malabi.venkatesan@us.army.mil
OI Helm, Richard/0000-0001-5317-0925
FU NIAID Food and Waterborne Integrated Research Network (FWD IRN)
[NO1-AI-30050]
FX The authors would like to thank Dr. E.V. Oaks for S. sonnei LPS and
Invaplex 50, Mr. Meng Shi for help with statistical analysis, Dr. Thomas
Hale and COL Robert Bowden for reading the manuscript and providing
encouragement and support. Studies involving the piglet model was
supported by the NIAID Food and Waterborne Integrated Research Network
(FWD IRN) award number NO1-AI-30050.
NR 85
TC 16
Z9 17
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD FEB 10
PY 2010
VL 28
IS 6
BP 1642
EP 1654
DI 10.1016/j.vaccine.2009.11.001
PG 13
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 565NX
UT WOS:000275301900030
PM 19932216
ER
PT J
AU Thera, MA
Doumbo, OK
Coulibaly, D
Laurens, MB
Kone, AK
Guindo, AB
Traore, K
Sissoko, M
Diallo, DA
Diarra, I
Kouriba, B
Daou, M
Dolo, A
Baby, M
Sissoko, MS
Sagara, I
Niangaly, A
Traore, I
Olotu, A
Godeaux, O
Leach, A
Dubois, MC
Ballou, WR
Cohen, J
Thompson, D
Dube, T
Soisson, L
Diggs, CL
Takala, SL
Lyke, KE
House, B
Lanar, DE
Dutta, S
Heppner, DG
Plowe, CV
AF Thera, Mahamadou A.
Doumbo, Ogobara K.
Coulibaly, Drissa
Laurens, Matthew B.
Kone, Abdoulaye K.
Guindo, Ando B.
Traore, Karim
Sissoko, Mady
Diallo, Dapa A.
Diarra, Issa
Kouriba, Bourema
Daou, Modibo
Dolo, Amagana
Baby, Mounirou
Sissoko, Mahamadou S.
Sagara, Issaka
Niangaly, Amadou
Traore, Idrissa
Olotu, Ally
Godeaux, Olivier
Leach, Amanda
Dubois, Marie-Claude
Ballou, W. Ripley
Cohen, Joe
Thompson, Darby
Dube, Tina
Soisson, Lorraine
Diggs, Carter L.
Takala, Shannon L.
Lyke, Kirsten E.
House, Brent
Lanar, David E.
Dutta, Sheetij
Heppner, D. Gray
Plowe, Christopher V.
TI Safety and Immunogenicity of an AMA1 Malaria Vaccine in Malian Children:
Results of a Phase 1 Randomized Controlled Trial
SO PLOS ONE
LA English
DT Article
ID APICAL MEMBRANE ANTIGEN-1; PLASMODIUM-FALCIPARUM MALARIA;
INSTITUTE-OF-RESEARCH; BLOOD-STAGE VACCINE; IMMUNE-RESPONSES;
ANTIBODIES; CANDIDATE; INHIBIT; ADULTS; INVASION
AB Background: The objective was to evaluate the safety and immunogenicity of the AMA1-based malaria vaccine FMP2.1/AS02(A) in children exposed to seasonal falciparum malaria.
Methodology/Principal Findings: A Phase 1 double blind randomized controlled dose escalation trial was conducted in Bandiagara, Mali, West Africa, a rural town with intense seasonal transmission of Plasmodium falciparum malaria. The malaria vaccine FMP2.1/AS02(A) is a recombinant protein (FMP2.1) based on apical membrane antigen 1 (AMA1) from the 3D7 clone of P. falciparum, formulated in the Adjuvant System AS02(A). The comparator vaccine was a cell-culture rabies virus vaccine (RabAvert (R)). One hundred healthy Malian children aged 1-6 years were recruited into 3 cohorts and randomized to receive either 10 mu g FMP2.1 in 0.1 mL AS02(A), or 25 mu g FMP2.1 in 0.25 mL AS02(A), or 50 mu g FMP2.1 50 mg in 0.5 mL AS02(A), or rabies vaccine. Three doses of vaccine were given at 0, 1 and 2 months, and children were followed for 1 year. Solicited symptoms were assessed for 7 days and unsolicited symptoms for 30 days after each vaccination. Serious adverse events were assessed throughout the study. Transient local pain and swelling were common and more frequent in all malaria vaccine dosage groups than in the comparator group, but were acceptable to parents of participants. Levels of anti-AMA1 antibodies measured by ELISA increased significantly (at least 100-fold compared to baseline) in all 3 malaria vaccine groups, and remained high during the year of follow up.
Conclusion/Significance: The FMP2.1/AS02(A) vaccine had a good safety profile, was well-tolerated, and induced high and sustained antibody levels in malaria-exposed children. This malaria vaccine is being evaluated in a Phase 2 efficacy trial in children at this site.
C1 [Thera, Mahamadou A.; Doumbo, Ogobara K.; Coulibaly, Drissa; Kone, Abdoulaye K.; Guindo, Ando B.; Traore, Karim; Sissoko, Mady; Diallo, Dapa A.; Diarra, Issa; Kouriba, Bourema; Daou, Modibo; Dolo, Amagana; Baby, Mounirou; Sissoko, Mahamadou S.; Sagara, Issaka; Niangaly, Amadou; Traore, Idrissa] Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali.
[Laurens, Matthew B.; Takala, Shannon L.; Lyke, Kirsten E.; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
[Olotu, Ally; Godeaux, Olivier; Leach, Amanda; Dubois, Marie-Claude; Ballou, W. Ripley; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium.
[Thompson, Darby; Dube, Tina] EMMES Corp, Rockville, MD USA.
[Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA.
[House, Brent; Lanar, David E.; Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA.
RP Thera, MA (reprint author), Univ Bamako, Malaria Res & Training Ctr, Bamako, Mali.
EM cplowe@medicine.umaryland.edu
RI Lanar, David/B-3560-2011; Laurens, Matthew/E-7293-2013
OI Laurens, Matthew/0000-0003-3874-581X
FU National Institute of Allergy and Infectious Diseases (NIAID)
[N01AI85346, U19AI065683]; Fogarty International Center, National
Institutes of Health [D43TW001589]; United States Department of Defense
[W81XWH-06-1-0427]; United States Agency for International Development
(USAID); Doris Duke Charitable Foundation; Howard Hughes Medical
Institute
FX Site development and the conduct of the trial were supported by contract
N01AI85346 and cooperative agreement U19AI065683 from the National
Institute of Allergy and Infectious Diseases (NIAID), grant D43TW001589
from the Fogarty International Center, National Institutes of Health,
and contract W81XWH-06-1-0427 from the United States Department of
Defense and the United States Agency for International Development
(USAID). Data management was provided by the EMMES Corporation through a
contract with NIAID. Vaccine production and laboratory assays were
supported by USAID, Washington, D. C. and by the Military Infectious
Diseases Research Program, Fort Detrick, Maryland. Program staff from
NIAID (the primary funder) contributed to study design discussions but
played no role in the data collection and analysis, decision to publish,
or preparation of the manuscript. Coauthors LS and CD from USAID (a
secondary funder) contributed to both protocol design and manuscript
preparation. CVP is supported by a Distinguished Clinical Scientist
Award from the Doris Duke Charitable Foundation and by the Howard Hughes
Medical Institute.
NR 32
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U1 1
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 4
PY 2010
VL 5
IS 2
AR e9041
DI 10.1371/journal.pone.0009041
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 554ZB
UT WOS:000274474400003
PM 20140214
ER
PT J
AU Peng, XQ
Damarla, M
Skirball, J
Nonas, S
Wang, XY
Han, EJ
Hasan, EJ
Cao, X
Boueiz, A
Damico, R
Tuder, RM
Sciuto, AM
Anderson, DR
Garcia, JGN
Kass, DA
Hassoun, PM
Zhang, JT
AF Peng, Xin-qi
Damarla, Mahendra
Skirball, Jarrett
Nonas, Stephanie
Wang, Xiao-ying
Han, Eugenia J.
Hasan, Emile J.
Cao, Xuan
Boueiz, Adel
Damico, Rachel
Tuder, Rubin M.
Sciuto, Alfred M.
Anderson, Dana R.
Garcia, Joe G. N.
Kass, David A.
Hassoun, Paul M.
Zhang, Jun-tian
TI Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress
through inhibition of p38 mitogen-activated protein kinase in mouse lung
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE mechanical stress; ventilator-associated lung injury; pulmonary
capillary leakage; PI3K/Akt/eNOS; p38 MAPK signalings; signals
cross-talk; pulmonary edema; wortmannin
ID NITRIC-OXIDE SYNTHASE; VASCULAR-PERMEABILITY; ENDOTHELIAL-CELLS;
XANTHINE OXIDOREDUCTASE; INDUCED APOPTOSIS; TRANSGENIC MICE;
DOWN-REGULATION; NO PRODUCTION; INJURY; PHOSPHORYLATION
AB Aim: To test the hypothesis that PI3K/Akt/eNOS signaling has a protective role in a murine model of ventilation associated lung injury (VALI) through down-regulation of p38 MAPK signaling.
Methods: Male C57BL/J6 (wild-type, WT) or eNOS knockout mice (eNOS(-/-)) were exposed to mechanical ventilation (MV) with low (LVT, 7 mL/kg) and high tidal volume (HVT, 20 mL/kg) for 0-4 h. A subset of WT mice was administered the specific inhibitors of PI3K (100 nmol/L Wortmannin [Wort], ip) or of p38 MAPK (SB203580, 2 mg/kg, ip) 1 h before MV. Cultured type II alveolar epithelial cells C10 were exposed to 18% cyclic stretch for 2 h with or without 20 nmol/L Wort pretreatment. At the end of the experiment, the capillary leakage in vivo was assessed by extravasation of Evans blue dye (EBD), wet/dry weight ratio and lung lavage protein concentration. The lung tissue and cell lysate were also collected for protein and histological review.
Results: MV decreased PI3K/Akt phosphorylation and eNOS expression but increased phospho-p38 MAPK expression along with a lung leakage of EBD. Inhibitions of phospho-Akt by Wort worsen the lung edema, whereas inhibition of p38 MAPK kinase restored activation of Akt together with alleviated capillary leakage. eNOS(-/-) mice showed an exacerbated lung edema and injury. The stretched C10 cells demonstrated that Wort diminished the activation of Akt, but potentiated phosphorylation of MAPK p38.
Conclusion: Our results indicate that PI-3K/Akt/eNOS pathway has significant protective effects in VALI by preventing capillary leakage, and that there is a cross-talk between PI3K/Akt and p38 MAPK pathways in vascular barrier dysfunction resulting from VALI.
C1 [Peng, Xin-qi; Sciuto, Alfred M.; Anderson, Dana R.] USA, Med Res Inst Chem Def, Div Analyt Toxicol, Aberdeen Proving Ground, MD 21010 USA.
[Damarla, Mahendra; Skirball, Jarrett; Han, Eugenia J.; Hasan, Emile J.; Cao, Xuan; Boueiz, Adel; Damico, Rachel; Hassoun, Paul M.] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD USA.
[Kass, David A.] Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA.
[Tuder, Rubin M.] Univ Colorado, Sch Med, Dept Med, Div Pulm Sci & Crit Care Med, Denver, CO USA.
[Nonas, Stephanie] Oregon Hlth & Sci Univ, Div Pulm & Crit Care Med, Portland, OR 97201 USA.
[Garcia, Joe G. N.] Univ Chicago, Pritzker Sch Med, Dept Med, Chicago, IL 60637 USA.
[Wang, Xiao-ying; Zhang, Jun-tian] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China.
RP Peng, XQ (reprint author), USA, Med Res Inst Chem Def, Div Analyt Toxicol, Aberdeen Proving Ground, MD 21010 USA.
EM xinqipeng@gmail.com; zhangjt@imm.ac.cn
RI Garcia, Joe/E-8862-2010
FU American Heart Association [0765286U]; American Lung Association of
Maryland; National Heart, Lung and Blood Institute [NIH R01 HL049441,
P50 HL 73994]
FX This work was supported by grants from American Heart Association
(Mid-Atlantic, Beginning Grant-in-Aid #0765286U), American Lung
Association of Maryland (Biomedical Research Grant, 2006) and the
National Heart, Lung and Blood Institute (NIH R01 HL049441; P50 HL
73994).
NR 38
TC 28
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U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD FEB
PY 2010
VL 31
IS 2
BP 175
EP 183
DI 10.1038/aps.2009.190
PG 9
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
SC Chemistry; Pharmacology & Pharmacy
GA 556GO
UT WOS:000274578400006
PM 20139900
ER
PT J
AU Gerard, BF
AF Gerard, Brian F.
TI Anisotropy and Voiding at High Strain Rates in a Mg Alloy Extrudate
SO ADVANCED MATERIALS & PROCESSES
LA English
DT Article
C1 [Gerard, Brian F.] Lehigh Univ, Bethlehem, PA 18015 USA.
RP Gerard, BF (reprint author), USA, Picatinny Arsenal, NJ USA.
EM brian.f.gerard@us.army.mil
NR 0
TC 0
Z9 0
U1 1
U2 2
PU ASM INT
PI MATERIALS PARK
PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002
USA
SN 0882-7958
J9 ADV MATER PROCESS
JI Adv. Mater. Process.
PD FEB
PY 2010
VL 168
IS 2
BP 16
EP 17
PG 2
WC Materials Science, Multidisciplinary
SC Materials Science
GA 559KO
UT WOS:000274823800003
ER
PT J
AU Aksamija, A
Yue, K
Kim, H
Grobler, F
Krishnamurti, R
AF Aksamija, Ajla
Yue, Kui
Kim, Hyunjoo
Grobler, Francois
Krishnamurti, Ramesh
TI Integration of knowledge-based and generative systems for building
characterization and prediction
SO AI EDAM-ARTIFICIAL INTELLIGENCE FOR ENGINEERING DESIGN ANALYSIS AND
MANUFACTURING
LA English
DT Article; Proceedings Paper
CT 3rd International Conference on Design Computing and Cognition
CY JUN 23-25, 2008
CL Georgia Inst Technol, Atlanta, GA
HO Georgia Inst Technol
DE Building Information Modeling; Knowledge-Based Model; Ontology; Shape
Grammar
ID SHAPE GRAMMARS; SIZAS HOUSES; MALAGUEIRA; LANGUAGE; BRAND
AB This paper discusses the integration of knowledge bases and shape grammars for the generation of building models, covering interaction, system, and implementation. Knowledge-based and generative systems are combined to construct a method for characterizing existing buildings, in particular, their interior layouts based on exterior features and certain other parameters such as location and real dimensions. The knowledge-based model contains information about spatial use, organization, elements, and contextual information, with the shape grammar principally containing style rules. Buildings are analyzed and layouts are generated through communication and interaction between these two systems. The benefit of using an interactive system is that the complementary properties of the two schemes are employed to strengthen the overall process. Ontologies capture knowledge relating to architectural design principles, building anatomy. structure, and systems. Shape grammar rules embody change through geometric manipulation and transformation. Existing buildings are analyzed using this approach, and three-dimensional models are automatically generated. Two particular building types. the vernacular rowhouse and high-rise apartment building, both from Baltimore, Maryland, are presented to illustrate the process and for comparing the utilized methodologies.
C1 [Grobler, Francois] USA, Corps Engineers Construct Engn Res Lab, Champaign, IL 61826 USA.
[Aksamija, Ajla] Perkins Will, Tech Lab, Chicago, IL USA.
[Yue, Kui; Krishnamurti, Ramesh] Carnegie Mellon Univ, Sch Architecture, Pittsburgh, PA 15213 USA.
[Kim, Hyunjoo] Calif State Univ Fullerton, Dept Civil & Environm Engn, Fullerton, CA 92634 USA.
RP Grobler, F (reprint author), USA, Corps Engineers Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA.
EM Francois.Grobler@erdc.usace.army.mi
NR 20
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U1 1
U2 5
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0890-0604
J9 AI EDAM
JI AI EDAM-Artif. Intell. Eng. Des. Anal. Manuf.
PD FEB
PY 2010
VL 24
IS 1
BP 3
EP 16
DI 10.1017/S0890060409990138
PG 14
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications; Engineering, Multidisciplinary;
Engineering, Manufacturing
SC Computer Science; Engineering
GA 553NW
UT WOS:000274375100002
ER
PT J
AU Tovanabutra, S
Sanders, EJ
Graham, SM
Mwangome, M
Peshu, N
McClelland, RS
Muhaari, A
Crossler, J
Price, MA
Gilmour, J
Michael, NL
McCutchan, FM
AF Tovanabutra, Sodsai
Sanders, Eduard J.
Graham, Susan M.
Mwangome, Mary
Peshu, Norbert
McClelland, R. Scott
Muhaari, Allan
Crossler, Jacqueline
Price, Matt A.
Gilmour, Jill
Michael, Nelson L.
McCutchan, Francine M.
TI Evaluation of HIV Type 1 Strains in Men Having Sex with Men and in
Female Sex Workers in Mombasa, Kenya
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Article
ID CIRCULATING RECOMBINANT FORM; MOLECULAR EPIDEMIOLOGY; GENETIC DIVERSITY;
ENVELOPE GLYCOPROTEIN; WESTERN KENYA; RISK-FACTORS; DRUG-USERS;
SUBTYPE-B; PREVALENCE; INFECTION
AB We compared HIV-1 strains in incident and prevalent infections in a cohort of men having sex with men (MSM) and female sex workers (FSW) near Mombasa, Kenya and conducted a cross-sectional study of viral isolates from a sample of HIV-1-infected MSM and FSW in Kilifi, Coast Province, Kenya. RNA extracted from plasma of 13 MSM, 9 FSW, and one heterosexual male was amplified by nested RT-PCR and the products were directly sequenced. HIV-1 strains from 21 individuals were characterized with one or more complete genome sequences, and two were sequenced in the Nef gene. The envelope quasispecies was also studied in one individual. Among MSM, eight strains were subtype A and five were recombinant. There were two epidemiologically linked pairs of sequences; one pair was subtype A and the other pair was a complex AA2CD recombinant of identical structure. Another MSM was dually infected with DG recombinant strains of related, but nonidentical, structure. MSM also harbored AC and AD recombinant strains. The FSW harbored seven subtype A strains, an AD recombinant, and an AA2D strain related to CRF16_A2D. The one heterosexual male studied had a subtype A infection. This MSM epidemic in Kenya appears to be of local origin, harboring many strains typical of the broader Kenyan epidemic. Characteristics of a close social network were identified, with extended chains of transmission, novel recombinant strains possibly generated within the network, and a relatively high proportion of recombinant and dual infections.
C1 [Tovanabutra, Sodsai] US Mil HIV Res Program, Henry M Jackson Fdn, Walter Reed Army Inst Res, Rockville, MD 20850 USA.
[Sanders, Eduard J.; Graham, Susan M.; Mwangome, Mary; Peshu, Norbert; Muhaari, Allan] Kenya Govt Med Res Ctr, Ctr Geog Med Res Coast, Kilifi, Kenya.
[Sanders, Eduard J.] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Headington, England.
[Graham, Susan M.; McClelland, R. Scott] Univ Washington, Seattle, WA 98109 USA.
[Price, Matt A.; Gilmour, Jill] Int AIDS Vaccine Initiat, New York, NY 10038 USA.
RP Tovanabutra, S (reprint author), US Mil HIV Res Program, Henry M Jackson Fdn, Walter Reed Army Inst Res, 1600 E Gude Dr, Rockville, MD 20850 USA.
EM stovanabutra@hivresearch.org
OI Graham, Susan/0000-0001-7847-8686
FU International AIDS Vaccine Initiative (IAVI)
FX We are grateful to the subjects for their participation in the study. We
thank the clinic staff of the KEMRI-clinic in Mtwapa, the laboratory
staff at the KEMRI-Wellcome Trust Research laboratories in Kilifi, Meera
Bose for technical assistance, and Eric Sanders-Buell for his advice on
HIV-1 cloning and sequencing. The study was supported by the
International AIDS Vaccine Initiative (IAVI). The opinions or assertions
contained herein are the private views of the authors, and are not to be
construed as official, or as reflecting true views of the Department of
the Army or the Department of Defense, the Kenya Medical Research
Institute, or IAVI. This article was published with permission from the
Director of KEMRI.
NR 39
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U1 0
U2 4
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD FEB
PY 2010
VL 26
IS 2
BP 123
EP 131
DI 10.1089/aid.2009.0115
PG 9
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 555PZ
UT WOS:000274526900001
PM 20156095
ER
PT J
AU Moawad, FJ
Maydonovitch, CL
Lake, JM
Veerappan, GR
AF Moawad, Fouad J.
Maydonovitch, Corinne L.
Lake, Jason M.
Veerappan, Ganesh R.
TI PPIs May Not Predispose to Eosinophilic Esophagitis
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Letter
C1 [Moawad, Fouad J.; Maydonovitch, Corinne L.; Lake, Jason M.; Veerappan, Ganesh R.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA.
RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, 6900 Georgia Ave, Washington, DC 20307 USA.
EM Fouad.Moawad@amedd.army.mil
NR 5
TC 3
Z9 3
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD FEB
PY 2010
VL 105
IS 2
BP 468
EP 469
DI 10.1038/ajg.2009.617
PG 3
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 554RP
UT WOS:000274452400031
PM 20139878
ER
PT J
AU Perez, F
Hujer, AM
Hulten, EA
Fishbain, J
Hujer, KM
Aron, D
Thweatt, K
Donskey, CJ
Bonomo, RA
AF Perez, Federico
Hujer, Andrea M.
Hulten, Edward A.
Fishbain, Joel
Hujer, Kristine M.
Aron, David
Thweatt, Katherine
Donskey, Curtis J.
Bonomo, Robert A.
TI Antibiotic resistance determinants in Acinetobacter spp and clinical
outcomes in patients from a major military treatment facility
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
ID BAUMANNII; INFECTION; BACTEREMIA; MORTALITY; IMPACT
AB We explored the association of antibiotic-resistant phenotypes and genotypes in Acinetobacter spp with clinical outcomes and characteristics in 75 patients from a major military treatment facility. Amikacin resistance was associated with nosocomial acquisition of A baumannii, and carbapenem resistance and bla(OXA-23) were associated with the need for mechanical ventilation. The presence of bla(OXA-23) also correlated with longer hospital and ICU stay. Associations between bla(OXA-23) and complexity, duration, and changes made to antibiotic regimens also existed. Copyright (C) 2010 by Elsevier Inc on behalf of the Association for Professionals in Infection Control and Epidemiology, Inc. (Am J Infect Control 2010; 38: 63-5.)
C1 [Bonomo, Robert A.] Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Infect Dis Sect, Res Serv, Cleveland, OH 44106 USA.
[Perez, Federico] Univ Hosp Case Med Ctr, Div Infect Dis & HIV Med, Cleveland, OH USA.
[Hulten, Edward A.; Fishbain, Joel] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA.
[Bonomo, Robert A.] Case Western Reserve Univ, Sch Med, Dept Mol Biol & Pharmacol, Cleveland, OH USA.
[Bonomo, Robert A.] Case Western Reserve Univ, Sch Med, Dept Microbiol, Cleveland, OH USA.
RP Bonomo, RA (reprint author), Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Infect Dis Sect, Res Serv, 10701 East Blvd, Cleveland, OH 44106 USA.
EM robert.bonomo@med.va.gov
FU Veterans Affairs Merit Review Program; VISN 10 Geriatric Research
Education and Clinical Center; National Institutes of Health [RO1
AI072219]; Wyeth Pharmaceuticals; Veterans Affairs Merit Review
FX Supported by the Veterans Affairs Merit Review Program, VISN 10
Geriatric Research Education and Clinical Center, and the National
Institutes of Health (RO1 AI072219; to R. A. B.); by a fellowship
sponsored by Wyeth Pharmaceuticals ( to F. P.); and by the Veterans
Affairs Merit Review Program ( to C.J.D.).
NR 9
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U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD FEB
PY 2010
VL 38
IS 1
BP 63
EP 65
DI 10.1016/j.ajic.2009.05.007
PG 3
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 559WQ
UT WOS:000274859400012
PM 19783325
ER
PT J
AU Stany, MP
Maxwell, GL
Rose, GS
AF Stany, Michael P.
Maxwell, G. Larry
Rose, G. Scott
TI Clinical Decision Making Using Ovarian Cancer Risk Assessment
SO AMERICAN JOURNAL OF ROENTGENOLOGY
LA English
DT Review
DE CA-125 level; ovarian cancer; risk assessment; screening
ID ORAL-CONTRACEPTIVE USE; ADNEXAL MASSES; POSTMENOPAUSAL WOMEN;
PREOPERATIVE DIAGNOSIS; BREAST-CANCER; TUMORS; BRCA1; MALIGNANCY;
MUTATIONS; CA-125
AB OBJECTIVE. Although any adnexal abnormality found at imaging can be concerning for an ovarian malignancy, the clinician must perform an evaluation to decide if the actual likelihood of malignancy justifies the risk of surgery. When determining the likelihood of an asympto-matic, incidental adnexal mass being malignant, the provider must answer one important question: Do the clinical findings warrant the potential morbidity of surgery? This article will focus on the decision making that goes into such an evaluation.
CONCLUSION. A patient's medical history, physical examination, CA-125 level, and imaging characteristics are all factors that impact the ultimate decision of whether a patient can be observed with repeat imaging or should proceed to surgical evaluation.
C1 [Stany, Michael P.; Maxwell, G. Larry; Rose, G. Scott] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA.
RP Rose, GS (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW,Bldg 2,Rm 2106, Washington, DC 20307 USA.
EM gaylord.rose@amedd.army.mil
NR 44
TC 4
Z9 4
U1 0
U2 0
PU AMER ROENTGEN RAY SOC
PI RESTON
PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA
SN 0361-803X
J9 AM J ROENTGENOL
JI Am. J. Roentgenol.
PD FEB
PY 2010
VL 194
IS 2
BP 337
EP 342
DI 10.2214/AJR.09.3669
PG 6
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 548HU
UT WOS:000273951900010
PM 20093593
ER
PT J
AU Grant, RJ
Baldwin, CD
Nalca, A
Zoll, S
Blyn, LB
Eshoo, MW
Matthews, H
Sampath, R
Whitehouse, CA
AF Grant, Rebecca J.
Baldwin, Carson D.
Nalca, Aysegul
Zoll, Scott
Blyn, Lawrence B.
Eshoo, Mark W.
Matthews, Heather
Sampath, Rangarajan
Whitehouse, Chris A.
TI Application of the Ibis-T5000 Pan-Orthopoxvirus Assay to Quantitatively
Detect Monkeypox Viral Loads in Clinical Specimens from Macaques
Experimentally Infected with Aerosolized Monkeypox Virus
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID MASS-SPECTROMETRY; RAPID IDENTIFICATION; ROCHE LIGHTCYCLER; SMALLPOX;
PCR; CONGO; DIFFERENTIATION; SURVEILLANCE; PATHOGENS; EFFICACY
AB Monkeypox Virus (MPXV), a member of the family Poxviridae and genus Orthopoxvirus. causes a smallpox-like disease in humans. A previously described pan-Orthopoxvirus assay, based on a broad-range polymerase chain reaction (PCR) coupled with electrospray ionization mass spectrometry (PCR/ESI-MS), was evaluated for its ability to detect MPXV front spiked human and aerosol-infected cynomolgous macaque (Macaca fascicularis) samples. Detection of MPXV DNA from macaque tissue. blood, and spiked human blood by the PCR/ESI-MS pan-Orthopoxvirus assay was comparable, albeit at slightly higher levels, to the Current gold standard method of real-time PCR with the pan-Orthopoxvirus assay and had a limit of detection of 200 plaque-forming units. Furthermore, the platform was able to distinguish MPXV and vaccinia Viruses that were spiked into macaque blood samples at various concentrations. This platform provides a new tool for the diagnosis and monitoring of orthopoxviral loads during vaccine or antiviral Studies, but also could provide rapid identification during natural Outbreaks or bioterrorism attacks.
C1 [Grant, Rebecca J.] USA, Med Res Inst Infect Dis, Div Sci & Technol, Ft Detrick, MD 21702 USA.
[Blyn, Lawrence B.; Eshoo, Mark W.; Matthews, Heather; Sampath, Rangarajan] Ibis Biosci, Carlsbad, CA USA.
RP Grant, RJ (reprint author), USA, Med Res Inst Infect Dis, Div Sci & Technol, 1301 Ditto Ave,Room 123, Ft Detrick, MD 21702 USA.
EM rebecca.j.grant@amedd.army.mil
FU Defense Advanced Research Projects Agency; Department of Homeland
Security [W81XWH-05-C-0116]; U.S. Defense Threat Reduction Agency
[114538]; Office of Biodefense Research Affairs National Institute of
Allergy and Infectious Diseases [A120-B11]; U.S. Army Medical Research
Institute of Infectious Diseases
FX This study was Supported by the Defense Advanced Research Projects
Agency, the Department of Homeland Security (contract no,
W81XWH-05-C-0116), the U.S. Defense Threat Reduction Agency (U.S. Army
Medical Research Institute of Infectious Diseases Research Plan
#114538), and the Office of Biodefense Research Affairs National
Institute of Allergy and Infectious Diseases (interagency agreement
A120-B11). This research was performed while Rebecca J. Grant held a
National Research Council Research Associateship Award at the U.S. Army
Medical Research Institute of Infectious Diseases.
NR 25
TC 5
Z9 5
U1 0
U2 0
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD FEB
PY 2010
VL 82
IS 2
BP 318
EP 323
DI 10.4269/ajtmh.2010.09-0361
PG 6
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 552CC
UT WOS:000274263300024
PM 20134011
ER
PT J
AU Capeding, RZ
Brion, JD
Caponpon, MM
Gibbons, RV
Jarman, RG
Yoon, IK
Libraty, DH
AF Capeding, Rosario Z.
Brion, Job D.
Caponpon, Mercydina M.
Gibbons, Robert V.
Jarman, Richard G.
Yoon, In-Kyu
Libraty, Daniel H.
TI The Incidence, Characteristics, and Presentation of Dengue Virus
Infections during Infancy
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID HEMORRHAGIC-FEVER; THAILAND; PATHOGENESIS; SEVERITY; ANTIBODY; CHILDREN;
BANGKOK; DISEASE
AB Infants are a vulnerable and unique Population at risk for dengue in endemic areas. This report describes the incidence and presenting clinical features of infant dengue virus (DENV) infections from a prospective community-based study performed between January 2007 and May 2009 in the Philippines. DENV3 was the predominant infecting serotype over a wide spectrum of disease severity ranging from inapparent infection to dengue hemorrhagic fever (DHF). In 2007, the incidence of inapparent DENV infections during infancy was 103 per 1,000 persons person-years and 6-fold higher than symptomatic dengue. The age-specific incidence of infant DHF was 0.5 per 1,000 persons over the age of 3-8 months, and it disappeared by age 9 months. A febrile seizure, macular rash, petechiae, and lower platelet count were presenting clinical features associated with DENV infection among infants with acute undifferentiated febrile illnesses, Community-based studies can help to delineate the incidence rates, disease spectrum, and clinical features of DENV infections during infancy.
C1 [Libraty, Daniel H.] Univ Massachusetts, Med Ctr, Ctr Infect Dis & Vaccinec Res, Sch Med, Worcester, MA 01655 USA.
[Brion, Job D.; Caponpon, Mercydina M.] San Pablo City Hlth Off, San Pablo, Laguna, Philippines.
Res Inst Trop Med, Dept Microbiol, Manila, Philippines.
Res Inst Trop Med, Dept Med, Manila, Philippines.
[Gibbons, Robert V.; Jarman, Richard G.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Capeding, Rosario Z.] Res Inst Trop Med, Dept Microbiol, Muntinlupa, Metro Manila, Philippines.
[Capeding, Rosario Z.] Res Inst Trop Med, Dept Med, Muntinlupa, Metro Manila, Philippines.
RP Libraty, DH (reprint author), Univ Massachusetts, Med Ctr, Ctr Infect Dis & Vaccinec Res, Sch Med, 55 Lake Ave N, Worcester, MA 01655 USA.
EM lerosecap@yahoo.com.ph; jdbrion@yahoo.com; drdinamendoza@yahoo.com;
robert.gibbons@afrims.org; richard.jarman@afrims.org;
InKyu.Yoon@afrims.org; daniel.libraty@umassmed.edu
FU National Institutes of Health [U01 AI065654]
FX The study was supported by National Institutes of Health Grant U01
AI065654. The contents of this publication are solely the responsibility
of the authors and do not necessarily reflect the official views of the
National Institutes of Health or the U.S. Department of Defense.
NR 25
TC 24
Z9 25
U1 0
U2 3
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD FEB
PY 2010
VL 82
IS 2
BP 330
EP 336
DI 10.4269/ajtmh.2010.09-0542
PG 7
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 552CC
UT WOS:000274263300026
PM 20134013
ER
PT J
AU Rice, RD
Parker, DM
Seery, JM
Arciero, CA
AF Rice, Robert D.
Parker, David M.
Seery, Jason M.
Arciero, Cletus A.
TI A Small Bowel Obstruction Secondary to a Meckel's Enterolith
SO AMERICAN SURGEON
LA English
DT Letter
C1 [Rice, Robert D.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA.
RP Rice, RD (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA.
EM Robert.D.Rice@amedd.army.mil
NR 6
TC 2
Z9 2
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI ATLANTA
PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA
SN 0003-1348
J9 AM SURGEON
JI Am. Surg.
PD FEB
PY 2010
VL 76
IS 2
BP 222
EP 224
PG 3
WC Surgery
SC Surgery
GA 556TV
UT WOS:000274616400023
PM 20336908
ER
PT J
AU Seery, JM
Reyes, AM
Rice, RD
Dodge, AN
Armstrong, PJ
AF Seery, Jason M.
Reyes, Angel M.
Rice, Robert D.
Dodge, Angela N.
Armstrong, Peter J.
TI Primary Venous Aneurysms: Two Case Reports
SO AMERICAN SURGEON
LA English
DT Letter
C1 [Seery, Jason M.] Dwight D Eisenhower Army Med Ctr, Attn Gen Surg Clin, Ft Gordon, GA 30905 USA.
RP Seery, JM (reprint author), Dwight D Eisenhower Army Med Ctr, Attn Gen Surg Clin, 300 Hosp Rd, Ft Gordon, GA 30905 USA.
EM jason.m.seery@amedd.army.mil
NR 5
TC 1
Z9 1
U1 0
U2 1
PU SOUTHEASTERN SURGICAL CONGRESS
PI ATLANTA
PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA
SN 0003-1348
J9 AM SURGEON
JI Am. Surg.
PD FEB
PY 2010
VL 76
IS 2
BP 224
EP 225
PG 2
WC Surgery
SC Surgery
GA 556TV
UT WOS:000274616400024
PM 20336909
ER
PT J
AU Bevilacqua, VLH
Nilles, JM
Rice, JS
Connell, TR
Schenning, AM
Reilly, LM
Durst, HD
AF Bevilacqua, Vicky L. H.
Nilles, J. Michael
Rice, Jeffrey S.
Connell, Theresa R.
Schenning, Amanda M.
Reilly, Lisa M.
Durst, H. Dupont
TI Ricin Activity Assay by Direct Analysis in Real Time Mass Spectrometry
Release Detection of Adenine Release
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID RIBOSOME-INACTIVATING PROTEINS; N-GLYCOSIDASE ACTIVITY; A-CHAIN;
EUKARYOTIC RIBOSOMES; RNA
AB Biotoxin activity assays typically involve multistep sample preparation, multicomponent reactions, multistep analysis, or a combination thereof. We report a single-step, real-time ricin activity assay that requires little or no sample preparation and employs direct analysis in real time mass spectrometry. The release of adenine from the inhomogeneous substrate herring sperm DNA by ricin was determined to be 53 +/- 2 pmol adenine per picomole of ricin per hour. This procedure can be readily adapted to any enzyme for which a reactant or product of low molecular weight (up to similar to 600) can be identified.
C1 [Bevilacqua, Vicky L. H.; Rice, Jeffrey S.; Reilly, Lisa M.; Durst, H. Dupont] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Nilles, J. Michael; Connell, Theresa R.; Schenning, Amanda M.] SAIC, Gunpowder Branch, Gunpowder, MD 21010 USA.
RP Bevilacqua, VLH (reprint author), USA, Edgewood Chem Biol Ctr, 5183 Black Hawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM Vicky.bevilacqua@us.army.mil
FU Defense Threat Reduction Agency [0602384BP]
FX We thank Drs. James A. Laramee and Rabih Jabbour for manuscript review,
Dr. Steven R. Channel and Mr. Alan Zulich for administrative support,
and the Defense Threat Reduction Agency for funding (Grant Program
Element 0602384BP).
NR 14
TC 24
Z9 24
U1 1
U2 18
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
J9 ANAL CHEM
JI Anal. Chem.
PD FEB 1
PY 2010
VL 82
IS 3
BP 798
EP 800
DI 10.1021/ac9025972
PG 3
WC Chemistry, Analytical
SC Chemistry
GA 548RK
UT WOS:000273983700009
PM 20055481
ER
PT J
AU Bleckner, LL
Bina, S
Kwon, KH
McKnight, G
Dragovich, A
Buckenmaier, CC
AF Bleckner, Lisa L.
Bina, Saiid
Kwon, Kyung H.
McKnight, Geselle
Dragovich, Anthony
Buckenmaier, Chester C., III
TI Serum Ropivacaine Concentrations and Systemic Local Anesthetic Toxicity
in Trauma Patients Receiving Long-Term Continuous Peripheral Nerve Block
Catheters
SO ANESTHESIA AND ANALGESIA
LA English
DT Article
ID PLASMA-PROTEIN BINDING; EPIDURAL INFUSION; SCIATIC BLOCK;
PHARMACOKINETICS; BUPIVACAINE; CONVULSIONS; ANALGESIA; EFFICACY
AB BACKGROUND: Ropivacaine is a long-acting local anesthetic used frequently for peripheral nerve blocks and continuous peripheral nerve block catheters. Combat trauma patients at Walter Reed Army Medical Center often receive continuous peripheral nerve block catheters as part of their pain regimen. These catheters remain in situ for several days to weeks. In this study, we evaluated the free ropivacaine drug levels over time in trauma patients by measuring the serum concentration of bound and unbound local anesthetic. The corresponding alpha(1)-acid glycoprotein concentration in patients with prolonged ropivacaine infusions was also measured.
METHODS: Fifteen patients were enrolled in the study; 2 patients were excluded because only a single ropivacaine level was obtained. Of the remaining 13 patients in the study, 2 had peripheral nerve catheters placed at the time of enrollment; the remaining 11 patients had catheters placed before enrollment. These patients were already receiving 0.2% ropivacaine infusions for a period of 18-126 h before the first assessment of local anesthetic level. Catheters infused 0.2% ropivacaine at a rate of 6-14 mL/h; catheter boluses were administered with 0.5% ropivacaine. Local anesthetic blood concentrations were scheduled to be measured on Days 1, 3, 5, 7, and 10 and every 3 days thereafter until all catheters were removed, although not all patients underwent each assessment. Specimens were assayed using high-performance liquid chromatography for total and free serum ropivacaine concentrations. alpha(1)-Acid glycoprotein was also measured.
RESULTS: Thirteen patients remained in the study, for a total of 59 blood samples. The median number of days catheters remained in situ for the duration of acute pain therapy was 7 days (range: 6-27 days). The median number of days catheters remained in situ after enrollment into the study was 7 days (range: 4-25 days). The median number of blood samples collected per patient was 4 (range: 2-10 samples). Two patients had isolated increased concentrations of free ropivacaine into a previously identified toxic range with no obvious mitigating factors; both patients had received a 300-mg bolus of 0.5% ropivacaine approximately 24 h before that blood collection. The median ropivacaine concentration over the length of the study was 0.11 mg/L (range: undetectable to 0.63 mg/L). During the first week of the study, the median change in ropivacaine concentration per patient was 0.00 mg/L (range: -0.35 to 0.47 mg/L).
CONCLUSION: Although 2 patients demonstrated isolated serum ropivacaine concentration spikes into a previously identified toxic range, continuous peripheral nerve block catheter management and local anesthetic doses as practiced at Walter Reed Army Medical Center did not result in clinically evident systemic ropivacaine toxicity. There was no correlation between free ropivacaine concentration and alpha(1)-acid glycoprotein concentration except in patients who had already been receiving ropivacaine infusions before entering the study. Despite this lack of correlation, the total duration of local anesthetic infusion did not seem to influence the free concentration of the drug. (Anesth Analg 2010;110:630-4)
C1 [Bleckner, Lisa L.; Kwon, Kyung H.; McKnight, Geselle; Buckenmaier, Chester C., III] Walter Reed Army Med Ctr, Dept Surg Anesthesia & Operat Serv, Washington, DC 20307 USA.
[Bleckner, Lisa L.; Bina, Saiid; Dragovich, Anthony; Buckenmaier, Chester C., III] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA.
RP Bleckner, LL (reprint author), 7301 Maple Ave, Chevy Chase, MD 20815 USA.
EM lbleckner@yahoo.com
FU John P. Murtha Neuroscience and Pain Institute; Henry M. Jackson
Foundation; departmental funds
FX Supported by John P. Murtha Neuroscience and Pain Institute, Henry M.
Jackson Foundation, and departmental funds.
NR 17
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Z9 19
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0003-2999
J9 ANESTH ANALG
JI Anesth. Analg.
PD FEB
PY 2010
VL 110
IS 2
BP 630
EP 634
DI 10.1213/ANE.0b013e3181c76a33
PG 5
WC Anesthesiology
SC Anesthesiology
GA 547XC
UT WOS:000273922100060
PM 19955504
ER
PT J
AU La Shell, MS
Otto, HF
Whisman, BA
Waibel, KH
White, AA
Calabria, CW
AF La Shell, Mark S.
Otto, Hans F.
Whisman, Bonnie A.
Waibel, Kirk H.
White, Andrew A.
Calabria, Christopher W.
TI ALLERGY TO PUMPKIN AND CROSS-REACTIVITY TO POLLENS AND OTHER FOODS
SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
LA English
DT Letter
C1 [La Shell, Mark S.] David Grant Med Ctr, Travis AFB, CA USA.
[Otto, Hans F.; Whisman, Bonnie A.; Calabria, Christopher W.] Wilford Hall USAF Med Ctr, San Antonio, TX USA.
[Waibel, Kirk H.] Brooke Army Med Ctr, San Antonio, TX USA.
[White, Andrew A.] Scripps Clin, La Jolla, CA 92037 USA.
RP La Shell, MS (reprint author), David Grant Med Ctr, Travis AFB, CA USA.
EM marklashell@gmail.com
NR 6
TC 1
Z9 1
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1081-1206
J9 ANN ALLERG ASTHMA IM
JI Ann. Allergy Asthma Immunol.
PD FEB
PY 2010
VL 104
IS 2
BP 178
EP 180
DI 10.1016/j.anai.2009.11.048
PG 3
WC Allergy; Immunology
SC Allergy; Immunology
GA 701OF
UT WOS:000285828400012
PM 20306822
ER
PT J
AU Carpenter, KM
Fowler, JM
Maxwell, GL
Andersen, BL
AF Carpenter, Kristen M.
Fowler, Jeffrey M.
Maxwell, G. Larry
Andersen, Barbara L.
TI Direct and Buffering Effects of Social Support Among Gynecologic Cancer
Survivors
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Gynecologic cancer; Cancer survivorship; Social support; Traumatic
stress; Depressive symptoms
ID QUALITY-OF-LIFE; EARLY-STAGE BREAST; POSTTRAUMATIC-STRESS-DISORDER;
PERSONAL COPING RESOURCES; DEPRESSIVE SYMPTOMS; ONCOLOGY-GROUP;
PSYCHOLOGICAL DISTRESS; ADJUVANT CHEMOTHERAPY; FUNCTIONAL ASSESSMENT;
CERVICAL-CANCER
AB There are few studies of QoL among long-term gynecologic cancer survivors; available data suggest significant sequelae of disease and treatment. Research clarifying circumstances that improve difficult survivorship trajectories is lacking.
The present study examines whether social support moderates the relationship between physical functioning and psychological outcomes by testing the stress-buffering hypothesis.
Participants (N = 260) were gynecologic cancer survivors (cervical, n = 47; endometrial, n = 133; ovarian, n = 69; vulvar, n = 11). Compromised physical health was conceptualized as multidimensional. Social support (SNI, PSS-Fa, PSS-Fr, ISEL) was tested as a buffer of adverse psychological outcomes (IES-R, CES-D).
Results for traumatic stress provided evidence for buffering; whereas social support was of general benefit for depressive symptoms. Effects varied by source and type of support.
These results suggest that circumstances for gynecologic cancer survivors burdened with physical symptoms may be worse for those with fewer support resources, providing needed insight into a common target of psychosocial interventions for cancer survivors.
C1 [Carpenter, Kristen M.; Andersen, Barbara L.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
[Fowler, Jeffrey M.; Andersen, Barbara L.] Ohio State Univ, Med Ctr, Ctr Comprehens Canc, Columbus, OH 43210 USA.
[Maxwell, G. Larry] Walter Reed Army Med Ctr, Gynecol Dis Ctr, Washington, DC 20307 USA.
[Maxwell, G. Larry] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA.
RP Carpenter, KM (reprint author), Ohio State Univ, Dept Psychol, 1835 Neil Ave,159 Psychol Bldg, Columbus, OH 43210 USA.
EM carpenter.292@osu.edu
RI Carpenter, Kristen/I-1569-2013
FU NCI NIH HHS [L30 CA136257, R01 CA092704, K05CA098133, R01CA92704, K05
CA098133]; NCRR NIH HHS [UL1 RR025755]
NR 83
TC 35
Z9 36
U1 4
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0883-6612
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD FEB
PY 2010
VL 39
IS 1
BP 79
EP 90
DI 10.1007/s12160-010-9160-1
PG 12
WC Psychology, Multidisciplinary
SC Psychology
GA 587SQ
UT WOS:000277013400009
PM 20151235
ER
PT J
AU Nissan, A
Protic, M
Bilchik, A
Eberhardt, J
Peoples, GE
Stojadinovic, A
AF Nissan, Aviram
Protic, Mladjan
Bilchik, Anton
Eberhardt, John
Peoples, George E.
Stojadinovic, Alexander
TI Predictive Model of Outcome of Targeted Nodal Assessment in Colorectal
Cancer
SO ANNALS OF SURGERY
LA English
DT Article
ID PROSPECTIVE MULTICENTER TRIAL; RESECTABLE COLON-CANCER; EARLY-STAGE
MELANOMA; SENTINEL NODE; BREAST-CANCER; LYMPH-NODES; CARCINOMA; BIOPSY;
VIVO; VALIDATION
AB Background: Improvement in staging accuracy is the principal aim of targeted nodal assessment in colorectal carcinoma. Technical factors independently predictive of false negative (FN) sentinel lymph node (SUN) mapping should be identified to facilitate operative decision making.
Purpose: To define independent predictors of FN SLN mapping and to develop a predictive model that Could support surgical decisions.
Patients and Methods: Data was analyzed from 2 completed prospective clinical trials involving 278 patients with colorectal carcinoma undergoing SLN mapping. Clinical outcome of interest was FN SLN(s),defined as one (s) with no apparent tumor cells in the presence of non-SLN metastases. To assess the independent predictive effect of a covariate for a nominal response (FN SLN), a logistic regression model was constructed and parameters estimated using maximum likelihood. A probabilistic Bayesian model was also trained and cross validated using 10-fold train-and-test sets to predict FN SLN mapping. Area under the curve (AUC) from receiver operating characteristics Curves of these predictions was calculated to determine the predictive value of the model.
Results: Number of SLNs (<3; P = 0.03) and tumor-replaced nodes (P < 0.01) independently predicted FN SLN. Cross validation of the model created with Bayesian Network Analysis effectively predicted FN SLN (area under the curve = 0.84-0.86). The positive and negative predictive values of the model are 83% and 97%, respectively.
Conclusion: This study supports a minimum threshold of 3 nodes for targeted nodal assessment in colorectal cancer, and establishes sufficient basis to Conclude that SLN mapping and biopsy cannot be justified in the presence of clinically apparent tumor-replaced nodes.
C1 [Nissan, Aviram; Protic, Mladjan; Bilchik, Anton; Peoples, George E.; Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA.
[Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA.
[Nissan, Aviram] Hadassah Hebrew Univ, Med Ctr, Dept Surg, Div Surg Oncol, Jerusalem, Israel.
[Protic, Mladjan] Clin Ctr Vojvodina, Clin Abdominal Endocrine & Transplantat Surg, Novi Sad, Serbia.
[Bilchik, Anton] Univ Calif Los Angeles, Dept Med, Los Angeles, CA USA.
[Eberhardt, John] DecisionQ Corp, Washington, DC USA.
[Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC USA.
RP Stojadinovic, A (reprint author), US Mil Canc Inst, 6900 Georgia Ave,Room 5C27A,NW, Washington, DC USA.
EM alexander.stojadinovic@amedd.army.mil
NR 37
TC 15
Z9 15
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0003-4932
J9 ANN SURG
JI Ann. Surg.
PD FEB
PY 2010
VL 251
IS 2
BP 265
EP 274
DI 10.1097/SLA.0b013e3181bd5187
PG 10
WC Surgery
SC Surgery
GA 549KC
UT WOS:000274046300014
PM 20054276
ER
PT J
AU Buckenmaier, CC
Kwon, KH
Howard, RS
McKnight, GM
Shriver, CD
Stojadinovic, A
AF Buckenmaier, C. C., III
Kwon, K. H.
Howard, R. S.
McKnight, G. M.
Shriver, C. D.
Stojadinovic, A.
TI Double-Blinded, Placebo Controlled Prospective Randomized Trial
Evaluating the Efficacy of Continuous Paravertebral Catheter Anesthesia
with Paravertebral Block in Breast Cancer Surgery
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology
CY MAR 03-07, 2010
CL St Louis, MO
SP Soc Surg Oncol
C1 [Buckenmaier, C. C., III; Kwon, K. H.; McKnight, G. M.] Walter Reed Army Med Ctr, Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Washington, DC 20307 USA.
[Howard, R. S.] Walter Reed Army Med Ctr, Dept Clin Invest, Div Biostat, Washington, DC 20307 USA.
[Shriver, C. D.; Stojadinovic, A.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD FEB
PY 2010
VL 17
SU 1
BP S29
EP S29
PG 1
WC Oncology; Surgery
SC Oncology; Surgery
GA 560KY
UT WOS:000274902700072
ER
PT J
AU Clifton, GT
Clive, K
Holmes, JP
Patil, R
Benavides, LC
Gates, JD
Mittendorf, EA
Stojadinovic, A
Ponniah, S
Peoples, GE
AF Clifton, G. T.
Clive, K.
Holmes, J. P.
Patil, R.
Benavides, L. C.
Gates, J. D.
Mittendorf, E. A.
Stojadinovic, A.
Ponniah, S.
Peoples, G. E.
TI Cumulative Findings from the E75 Peptide Vaccine Adjuvant Trials in
Breast Cancer
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology
CY MAR 03-07, 2010
CL St Louis, MO
SP Soc Surg Oncol
C1 [Clifton, G. T.; Clive, K.; Benavides, L. C.; Gates, J. D.; Peoples, G. E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Holmes, J. P.] USN, San Diego Med Ctr, San Diego, CA 92152 USA.
[Patil, R.] Windber Med Ctr, Windber, PA USA.
[Mittendorf, E. A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Stojadinovic, A.] Walter Reed Army Med Ctr, Washington, DC USA.
[Ponniah, S.] USUHS, Canc Vaccine Dev Program, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD FEB
PY 2010
VL 17
SU 1
BP S50
EP S50
PG 1
WC Oncology; Surgery
SC Oncology; Surgery
GA 560KY
UT WOS:000274902700135
ER
PT J
AU Clive, K
Tyler, JA
Barchie, MF
Sutcliffe, JB
Kirkpatrick, AD
Banks, KP
Bell, LM
Saenger, JS
Peoples, GE
AF Clive, K.
Tyler, J. A.
Barchie, M. F.
Sutcliffe, J. B.
Kirkpatrick, A. D.
Banks, K. P.
Bell, L. M.
Saenger, J. S.
Peoples, G. E.
TI Are Increased Mastectomy Rates Based on Pretreatment MRI Findings
Justified?
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology
CY MAR 03-07, 2010
CL St Louis, MO
SP Soc Surg Oncol
C1 [Clive, K.; Tyler, J. A.; Barchie, M. F.; Sutcliffe, J. B.; Kirkpatrick, A. D.; Banks, K. P.; Bell, L. M.; Saenger, J. S.; Peoples, G. E.] Brooke Army Med Ctr, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD FEB
PY 2010
VL 17
SU 1
BP S51
EP S51
PG 1
WC Oncology; Surgery
SC Oncology; Surgery
GA 560KY
UT WOS:000274902700139
ER
PT J
AU Ellsworth, R
Weyandt, JD
Fantacone-Campbell, JL
Deyarmin, B
Ellsworth, DL
Hooke, JA
Shriver, CD
AF Ellsworth, R.
Weyandt, J. D.
Fantacone-Campbell, J. L.
Deyarmin, B.
Ellsworth, D. L.
Hooke, J. A.
Shriver, C. D.
TI Molecular characterization of breast cancer progression: early lesions
are not genetically advanced
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology
CY MAR 03-07, 2010
CL St Louis, MO
SP Soc Surg Oncol
C1 [Ellsworth, R.] Henry M Jackson Fdn Advancement Mil Med, Windber, PA USA.
[Weyandt, J. D.; Deyarmin, B.; Ellsworth, D. L.] Windber Res Inst, Windber, PA USA.
[Fantacone-Campbell, J. L.; Hooke, J. A.; Shriver, C. D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD FEB
PY 2010
VL 17
SU 1
BP S46
EP S46
PG 1
WC Oncology; Surgery
SC Oncology; Surgery
GA 560KY
UT WOS:000274902700121
ER
PT J
AU Hwang, PF
Hampton, CB
Potter, BK
Shoemaker, RG
Graybill, JC
Forsberg, JA
Schaefer, RA
Peoples, GE
Stojadinovic, A
AF Hwang, P. F.
Hampton, C. B.
Potter, B. K.
Shoemaker, R. G.
Graybill, J. C.
Forsberg, J. A.
Schaefer, R. A.
Peoples, G. E.
Stojadinovic, A.
TI Impact of Local Recurrence on Extremity and Pelvic Soft Tissue Sarcoma
Survival
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology
CY MAR 03-07, 2010
CL St Louis, MO
SP Soc Surg Oncol
C1 [Potter, B. K.; Schaefer, R. A.; Stojadinovic, A.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC USA.
[Peoples, G. E.] Uniformed Serv Univ Hlth Sci, Brooke Army Med Ctr, US Mil Canc Inst, Ft Sam Houston, TX USA.
RI Forsberg, Jonathan/K-2116-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD FEB
PY 2010
VL 17
SU 1
BP S127
EP S127
PG 1
WC Oncology; Surgery
SC Oncology; Surgery
GA 560KY
UT WOS:000274902700390
ER
PT J
AU Webb, RC
Howard, RS
Stojadinovic, A
Burch, HB
AF Webb, R. C.
Howard, R. S.
Stojadinovic, A.
Burch, H. B.
TI Post Operative Thyroglobulin Level: Significant Marker of Recurrent
Papillary Thyroid Carcinoma
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Meeting Abstract
CT 63rd Annual Cancer Symposium of the Society-of-Surgical-Oncology
CY MAR 03-07, 2010
CL St Louis, MO
SP Soc Surg Oncol
C1 [Webb, R. C.; Howard, R. S.; Stojadinovic, A.; Burch, H. B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD FEB
PY 2010
VL 17
SU 1
BP S61
EP S61
PG 1
WC Oncology; Surgery
SC Oncology; Surgery
GA 560KY
UT WOS:000274902700174
ER
PT J
AU Rice, RD
Armstrong, PJ
AF Rice, Robert D.
Armstrong, Peter J.
TI Brachial Artery Fibromuscular Dysplasia
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID DIGITAL EMBOLI; THERAPY; DISEASE
AB Fibromuscular dysplasia is a rare vascular disease that is characterized as nonatherosclerotic and noninflammatory in nature. This disease most commonly afflicts the renal and cerebrovascular beds but can rarely affect the upper extremity. We present the case of a 76-year-old woman who complained of a symptom complex, congruent with Raynaud's phenomenon on the right side. The patient had evidence of distal ischemia without the classic angiographic evidence of fibromuscular dysplasia on arteriography. The abnormal arterial section of the right brachial artery was resected and grafted with reversed saphenous vein. She has had no reoccurrence of her symptoms and no stenosis of her graft over a 3-year follow-up period.
C1 [Rice, Robert D.; Armstrong, Peter J.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Vasc Surg Serv, Ft Gordon, GA 30905 USA.
RP Rice, RD (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA.
EM robert.d.rice@us.army.mil
NR 13
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0890-5096
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD FEB
PY 2010
VL 24
IS 2
AR 255.e1
DI 10.1016/j.avsg.2009.05.012
PG 4
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA 549US
UT WOS:000274080400018
PM 19896327
ER
PT J
AU Nasveld, PE
Edstein, MD
Reid, M
Brennan, L
Harris, IE
Kitchener, SJ
Leggat, PA
Pickford, P
Kerr, C
Ohrt, C
Prescott, W
AF Nasveld, Peter E.
Edstein, Michael D.
Reid, Mark
Brennan, Leonard
Harris, Ivor E.
Kitchener, Scott J.
Leggat, Peter A.
Pickford, Philip
Kerr, Caron
Ohrt, Colin
Prescott, William
CA Tafenoquine Study Team
TI Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy
of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune
Subjects
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID AUSTRALIAN DEFENSE FORCE; PLASMODIUM-FALCIPARUM MALARIA; EAST TIMOR;
CONTROLLED TRIAL; PRIMAQUINE; VIVAX; CHEMOPROPHYLAXIS; PERSONNEL;
TRAVELERS; REGIMENS
AB This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis. In a randomized (3:1), double-blinded study, Australian soldiers received weekly malaria prophylaxis with 200 mg tafenoquine (492 subjects) or 250 mg mefloquine (162 subjects) for 6 months on a peacekeeping deployment to East Timor. After returning to Australia, tafenoquine-receiving subjects received a placebo and mefloquine-receiving subjects received 30 mg primaquine daily for 14 days. There were no clinically significant differences between hematological and biochemical parameters of the treatment groups. Treatment-related adverse events for the two groups were similar (tafenoquine, 13.4%; mefloquine, 11.7%). Three subjects on tafenoquine (0.6%) and none on mefloquine discontinued prophylaxis because of possible drug-related adverse events. No diagnoses of malaria occurred for either group during deployment, but 4 cases (0.9%) and 1 case (0.7%) of Plasmodium vivax infection occurred among the tafenoquine and mefloquine groups, respectively, up to 20 weeks after discontinuation of medication. In a subset of subjects recruited for detailed safety assessments, treatment-related mild vortex keratopathy was detected in 93% (69 of 74) of tafenoquine subjects but none of the 21 mefloquine subjects. The vortex keratopathy was not associated with any effect on visual acuity and was fully resolved in all subjects by 1 year. Tafenoquine appears to be safe and well tolerated as malaria prophylaxis. Although the volunteers' precise exposure to malaria could not be proven in this study, tafenoquine appears to be a highly efficacious drug for malaria prophylaxis.
C1 [Nasveld, Peter E.] Univ Queensland, Ctr Mil & Vet Hlth, Mayne Med Sch, Herston, Qld 4006, Australia.
[Nasveld, Peter E.; Edstein, Michael D.; Reid, Mark; Brennan, Leonard; Harris, Ivor E.; Kitchener, Scott J.; Leggat, Peter A.] Australian Army Malaria Inst, Brisbane, Qld, Australia.
[Pickford, Philip; Kerr, Caron] GlaxoSmithKline Res & Dev Ltd, Harlow, Essex, England.
[Ohrt, Colin] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
[Prescott, William] US Army Med Mat Dev Act, Frederick, MD USA.
RP Nasveld, PE (reprint author), Univ Queensland, Ctr Mil & Vet Hlth, Mayne Med Sch, Herston, Qld 4006, Australia.
EM P.Nasveld@uq.edu.au
RI Russell, Bruce/A-9240-2011; Kitchener, Scott/M-1885-2013
OI Russell, Bruce/0000-0003-2333-4348; Kitchener, Scott/0000-0002-2656-7588
FU U.S. Army Medical Materiel Development Activity; GlaxoSmithKline
Research & Development Limited; Australian Defence Force
FX Financial support was from the U.S. Army Medical Materiel Development
Activity, GlaxoSmithKline Research & Development Limited, and the
Australian Defence Force.
NR 23
TC 36
Z9 36
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD FEB
PY 2010
VL 54
IS 2
BP 792
EP 798
DI 10.1128/AAC.00354-09
PG 7
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 547BR
UT WOS:000273860600029
PM 19995933
ER
PT J
AU Stojadinovic, A
Ahuja, N
Nazarian, SM
Segev, DL
Jacobs, L
Wang, YC
Eberhardt, J
Zeiger, MA
AF Stojadinovic, Alexander
Ahuja, Nita
Nazarian, Susanna M.
Segev, Dorry L.
Jacobs, Lisa
Wang, Yongchun
Eberhardt, John
Zeiger, Martha A.
TI Translational Research in Surgical Disease
SO ARCHIVES OF SURGERY
LA English
DT Review
ID GASTROINTESTINAL STROMAL TUMORS; MALIGNANT THYROID-TUMORS; KIDNEY PAIRED
DONATION; METASTATIC COLORECTAL-CANCER; HER2-POSITIVE BREAST-CANCER;
GENE-EXPRESSION; NEOINTIMAL HYPERPLASIA; ADJUVANT CHEMOTHERAPY;
REVERSE-TRANSCRIPTASE; IMATINIB MESYLATE
AB Objective: To review cutting-edge, novel, implemented and potential translational research and to provide a glimpse into rich, innovative, and brilliant approaches to everyday surgical problems.
Data Sources: Scientific literature and unpublished results.
Study Selection: Articles reviewed were chosen based on innovation and application to surgical diseases.
Data Extraction: Each section was written by a surgeon familiar with cutting-edge and novel research in their field of expertise and interest.
Data Synthesis: Articles that met criteria were summarized in the manuscript.
Conclusions: Multiple avenues have been used for the discovery of improved means of diagnosis, treatment, and overall management of patients with surgical diseases. These avenues have incorporated the use of genomics, electrical impedence, statistical and mathematical modeling, and immunology.
C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA.
[Ahuja, Nita; Jacobs, Lisa; Wang, Yongchun; Zeiger, Martha A.] Johns Hopkins Univ, Sch Med, Div Endocrine & Surg Oncol, Baltimore, MD USA.
[Nazarian, Susanna M.] Johns Hopkins Univ, Sch Med, Div Vasc Surg, Baltimore, MD USA.
[Segev, Dorry L.] Johns Hopkins Univ, Sch Med, Dept Surg, Div Transplantat, Baltimore, MD 21205 USA.
[Eberhardt, John] Healthcare DecisionQ Corp, Washington, DC USA.
RP Zeiger, MA (reprint author), 600 N Wolfe St,Blalock 606, Baltimore, MD 21287 USA.
EM mzeiger@jhmi.edu
RI Ahuja, Nita/H-1064-2011
NR 60
TC 1
Z9 1
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0004-0010
J9 ARCH SURG-CHICAGO
JI Arch. Surg.
PD FEB
PY 2010
VL 145
IS 2
BP 187
EP 196
PG 10
WC Surgery
SC Surgery
GA 554XG
UT WOS:000274468900018
PM 20157088
ER
PT J
AU Lande, RG
Tarpley, V
Francis, JL
Boucher, R
AF Lande, R. Gregory
Tarpley, Vanita
Francis, Jennifer L.
Boucher, Rebecca
TI Combat Trauma Art Therapy Scale
SO ARTS IN PSYCHOTHERAPY
LA English
DT Article
DE Art therapy; Combat; Rating scale
ID MENTAL-HEALTH PROBLEMS; IRAQ
AB This study correlated an art therapy descriptive technique originally applied to adolescent burn victims with adult combat-related victims in an effort to identify art themes and graphic elements associated with post-traumatic stress disorder. The designed rating instrument, referred to as the Combat Trauma Art Therapy Scale (CTATS), consisted of 62 items aimed to detect common themes associated with war time experiences. Using the CTAS, raters examined 158 pictures, with depictions of women, violence, and combat interwoven, suggesting an ongoing struggle to cope with the emotional aftermath of recent traumatic experiences. Published by Elsevier Inc.
C1 [Lande, R. Gregory; Tarpley, Vanita; Francis, Jennifer L.; Boucher, Rebecca] Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA.
RP Lande, RG (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM rglande@medscape.com
NR 11
TC 2
Z9 2
U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-4556
J9 ART PSYCHOTHER
JI Arts Psychother.
PD FEB
PY 2010
VL 37
IS 1
BP 42
EP 45
DI 10.1016/j.aip.2009.09.007
PG 4
WC Psychology, Clinical; Rehabilitation
SC Psychology; Rehabilitation
GA 563MN
UT WOS:000275136700007
ER
PT J
AU Bedno, SA
Li, YZ
Han, WW
Cowan, DN
Scott, CT
Cavicchia, MA
Niebuhr, DW
AF Bedno, Sheryl A.
Li, Yuanzhang
Han, Weiwei
Cowan, David N.
Scott, Christine T.
Cavicchia, Melinda A.
Niebuhr, David W.
TI Exertional Heat Illness Among Overweight US Army Recruits In Basic
Training
SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE military; obesity; heatstroke; physical fitness
ID RISK-FACTORS; UNITED-STATES; FITNESS; OBESITY; WORKERS; STRESS
AB BEDNO SA, LI Y, HAN K COWAN DN, SCOTT CT, CAVICCHIA MA, NIEBUHR DW. Exertional heat illness among overweight U.S. Army recruits in basic training. Aviat Space Environ Med 2010; 81:107-11.
Introduction: Heat illness has not declined in the U.S. military despite preventive measures. The increase in overweight recruits entering the U.S. military may lead to an increase in heat-related events. This study compares the risk of heat illness among U.S. Army recruits who exceeded body fat standards at accession to those who met standards. Methods: Recruits with excess body fat and qualified applicants to the Army were required to take a preaccession fitness test during the study period (February 2005 through September 2006). The test included a 5-min step test and 1-min push-up challenge, scored as pass or fail. Incidence and outpatient usage for heat illness (any beat illness, heat stroke, heat exhaustion, and other heat illness) at 90 d of service were compared in 9667 male recruits of whom 826 had excess body fat and 8841 were qualified. There were too few beat events among women for analysis. Results: The incidence odds ratio among male recruits with excess body fat compared to qualified male recruits was 3.63 (95% CI: 1.92, 6.85). Men with excess body fat had an increased incidence of heat illness with a rate ratio of 7.25 (95% CI: 4.17, 12.61). Discussion: Although there were few heat illness events, the results indicate a significantly increased risk of heat illness and outpatient utilization among male recruits with excess body fat. It was estimated that approximately 70% of the relative risk for heat illnesses in men with excess body fat during basic training was associated with exceeding body fat standards. These findings may have implications for military accession and training.
C1 [Li, Yuanzhang; Han, Weiwei; Cowan, David N.; Cavicchia, Melinda A.; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Silver Spring, MD USA.
[Bedno, Sheryl A.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Occupat & Environm Med Residency Program, Bethesda, MD 20814 USA.
[Scott, Christine T.] Med Examinat Review Board, Dept Def, Colorado Springs, CO USA.
RP Bedno, SA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Occupat & Environm Med Residency Program, 4301 Jones Bridge Rd,Rm A-1040A, Bethesda, MD 20814 USA.
EM sheryl.bedno@usuhs.mil
OI Li, Yuanzhang/0000-0001-8872-4430
FU U.S. Army Accession Command
FX We would like to thank Ms. Janice Gary and Ms. Vielka Rivera, Accession
Medical Standards Analysis & Research Activity (AMSARA), Walter Reed
Army Institute of Research, for their administrative support.; This
study was funded by the U.S. Army Accession Command.; The views
expressed are those of the authors and should not be construed to
represent the positions of the Department of the Army or Department of
Defense.; Authors and affiliations: Sheryl A. Bedno, M.D., M.P.H.,
Occupational and Environmental Medicine Residency, Department of
Preventive Medicine and Biometrics, Uniformed Services University of the
Health Sciences, Bethesda, MD; Yuanzhang Li, Ph.D., Weiwei Han, M.S.,
David N. Cowan, Ph.D., M.P.H., Melida A. Cavicchia, M.D., M.P.H., and
David W. Niebuhr, M.D., M.P.H., Department of Epidemiology, Walter Reed
Army Institute of Research, Silver Spring, MD; and Christine T. Scott,
M.D., M.P.H., Department of Defense Medical Examination Review Board,
Colorado Springs, CO.
NR 20
TC 32
Z9 33
U1 1
U2 16
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 0095-6562
J9 AVIAT SPACE ENVIR MD
JI Aviat. Space Environ. Med.
PD FEB
PY 2010
VL 81
IS 2
BP 107
EP 111
DI 10.3357/ASEM.2623.2010
PG 5
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Sport Sciences
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Sport Sciences
GA 549QE
UT WOS:000274067900003
PM 20131650
ER
PT J
AU Sethuraman, G
Ryan, KL
Rickards, CA
Convertino, VA
AF Sethuraman, Girish
Ryan, Kathy L.
Rickards, Caroline A.
Convertino, Victor A.
TI Ectopy in Trauma Patients: Cautions for Use of Heart Period Variability
in Medical Monitoring
SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE physiologic monitoring; heart rate variability; heart rate complexity;
hypovolemia
ID REMOTE TRIAGE; MORTALITY; COMPLEXITY; STRESS; BEATS; CARE
AB SETHURAMAN G, RYAN KL, RICKARDS CA, CONVERTINO VA. Ectopy in trauma patients: cautions for use of heart period variability in medical monitoring. Aviat Space Environ Med 2010; 81:125-9.
Introduction: Heart period variability measurements have been proposed for use in early prediction of mortality or the requirement for life-saving interventions in trauma patients. However, the presence of even one ectopic beat (EB) and/or electromechanical noise compromises the accurate calculation of heart period variability. We tested the hypothesis that ECGs from trauma patients exhibit a greater frequency of EBs than healthy human research subjects. Methods: Continuous ECGs were recorded in 20 healthy human subjects at rest, 108 healthy human subjects undergoing experimentally induced progressive central hypovolemia (via lower body negative pressure, LBNP), and 245 trauma patients. The proportions of subjects/patients with at least one EB were identified in each group. Results: ECG waveforms from 20% and 18% of healthy human subjects at rest or undergoing LBNP, respectively, contained at least one EB. ECG waveforms from 36% of the trauma patients were found to contain either EBs (35%) or electromechanical noise (1%). Conclusions: A significant number of EBs occur in healthy Subjects both at rest and during progressive reduction in central blood volume, and trauma is associated with a near doubling of this incidence. As both EBs and noise result in invalid heart period variability calculations, these metrics as currently calculated Could not be used in approximately 36% of trauma patients. The limited use in nearly two of every five trauma patients indicate that it is unlikely that continuous heart period variability measurements could substantially improve pre-hospital or emergency room decision-support in trauma.
C1 [Sethuraman, Girish; Ryan, Kathy L.; Rickards, Caroline A.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Rickards, Caroline A.] Univ Texas San Antonio, San Antonio, TX USA.
RP Ryan, KL (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM kathy.ryan@amedd.army.mil
FU U.S. Army Medical Research and Materiel Command Combat Casualty Care
Research Program
FX This work was funded by the U.S. Army Medical Research and Materiel
Command Combat Casualty Care Research Program. We thank Mr. Gary Muniz
and Mr. Gilbert Moralez for their superb technical assistance in
analyzing data. Data were collected under Cooperative Research and
Development Agreement W81XWH-06-0144 between the U.S. Army Institute of
Surgical; The opinions or assertions contained herein are the private
views of the authors and are not to be construed as official or as
reflecting the views of the Department of the Army or the Department of
Defense.; Authors and affiliations: Girish Sethuraman, M.D., M.P.H.,
Kathy L. Ryan, B.S., Ph.D., Caroline A. Rickards, B.App.Sci.(Hons.),
Ph.D., and Victor A. Convertino, M.A., Ph.D., U.S. Army Instititue of
Surgical Research, Fort Sam Houston, TX; and Caroline A. Rickards,
B.App. Sci.(Hons.), Ph.D., the University of Texas at San Antonio, San
Antonio, TX.
NR 23
TC 6
Z9 6
U1 0
U2 0
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 0095-6562
J9 AVIAT SPACE ENVIR MD
JI Aviat. Space Environ. Med.
PD FEB
PY 2010
VL 81
IS 2
BP 125
EP 129
DI 10.3357/ASEM.2597.2010
PG 5
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Sport Sciences
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Sport Sciences
GA 549QE
UT WOS:000274067900006
PM 20131653
ER
PT J
AU Song, Y
Elias, V
Wong, CP
Scrimgeour, AG
Ho, E
AF Song, Yang
Elias, Valerie
Wong, Carmen P.
Scrimgeour, Angus G.
Ho, Emily
TI Zinc transporter expression profiles in the rat prostate following
alterations in dietary zinc
SO BIOMETALS
LA English
DT Article
DE Zinc transporter; ZnT2; Prostate; Marginal zinc deficiency
ID CITRATE METABOLISM; EPITHELIAL-CELLS; DOWN-REGULATION; MAMMARY CELLS;
DNA-DAMAGE; CANCER; DEFICIENCY; LACTATION; PROLACTIN; VARIANTS
AB Zinc plays important roles in numerous cellular activities and physiological functions. Intracellular zinc levels are strictly maintained by zinc homeostatic mechanisms. Zinc concentrations in the prostate are the highest of all soft tissues and could be important for prostate health. However, the mechanisms by which the prostate maintains high zinc levels are still unclear. In addition, the response of the prostate to alterations in dietary zinc is unknown. The current study explored cellular zinc levels and zinc transporter expression profiles in the lobes of the prostate during dietary marginal zinc depletion. Rats were given either zinc-adequate (ZA, 30 mg Zn/kg) or marginal zinc-deficient (MZD, 5 mg Zn/kg) diet for 9 weeks. In addition, a subgroup of the MZD rats was supplemented with phytase (1,500 unit/kg diet) to improve zinc bioavailability. We found that both zinc concentrations and ZnT2 expression in the prostate dorsolateral lobes were substantially higher than in the ventral lobes (P < 0.05). Marginal zinc depletion significantly decreased ZnT2 expression in the dorsolateral lobes (P < 0.05), and phytase supplementation had a trend to increase ZnT2 expression. In addition, of all measured zinc transporters, only ZnT2 mRNA abundance was significantly correlated to the zinc concentrations in the dorsolateral lobe. No correlations were found between zinc transporter expression and zinc concentrations in the ventral lobes. These results indicate that ZnT2 may play a significant role in the maintenance of zinc homeostasis in the prostate.
C1 [Song, Yang; Elias, Valerie; Wong, Carmen P.; Ho, Emily] Oregon State Univ, Dept Nutr & Exercise Sci, Corvallis, OR 97331 USA.
[Scrimgeour, Angus G.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
[Ho, Emily] Oregon State Univ, Linus Pauling Inst Sci & Med, Corvallis, OR 97331 USA.
RP Ho, E (reprint author), Oregon State Univ, Dept Nutr & Exercise Sci, 103 Milam Hall, Corvallis, OR 97331 USA.
EM emily.ho@oregonstate.edu
RI Song, Yang/D-6331-2011
FU Oregon AES [OR00735]; Environmental Health Science Center at Oregon
State University (NIEHS) [P30 ES00210]; US Army MRMC
FX We thank Dr. Shannon Kelleher for the generous gift of ZnT2 antibodies.
We gratefully acknowledge the WM Keck Collaboratory at Oregon State
University for their assistance in conducting these studies. This study
was funded by Oregon AES (OR00735), and the Environmental Health Science
Center at Oregon State University (NIEHS P30 ES00210) and by the US Army
MRMC. The opinions or assertions contained herein are the private views
of the authors and are not to be construed as official or as reflecting
the views of the Army or the Department of Defense.
NR 32
TC 13
Z9 13
U1 0
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0966-0844
J9 BIOMETALS
JI Biometals
PD FEB
PY 2010
VL 23
IS 1
BP 51
EP 58
DI 10.1007/s10534-009-9266-8
PG 8
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 536ZX
UT WOS:000273083600005
PM 19760107
ER
PT J
AU Long, JW
Laskoski, M
Keller, TM
Pettigrew, KA
Zimmerman, TN
Qadri, SB
Peterson, GW
AF Long, Jeffrey W.
Laskoski, Matthew
Keller, Teddy M.
Pettigrew, Katherine A.
Zimmerman, T'revor N.
Qadri, Syed B.
Peterson, Gregory W.
TI Selective-combustion purification of bulk carbonaceous solids to produce
graphitic nanostructures
SO CARBON
LA English
DT Article
ID HYDROGEN STORAGE; NANOTUBE FORMATION; IN-SITU; NANOPARTICLE
COMPOSITIONS; CATALYTIC GRAPHITIZATION; RAMAN-SPECTROSCOPY; OXIDATION;
ENERGY; NANOFIBERS; SPECTRA
AB We demonstrate the use of simple thermal oxidation processes to purify bulk carbon composites produced from thermosets, which were formulated from precursor compositions containing a melt-processible organometallic Ni catalyst in an excess of carbon source. The as-pyrolyzed carbonaceous solids comprise Ni nanoparticles and interpenetrating amorphous and graphitic carbon domains, where the fraction of crystalline carbon is determined primarily by the carbonization temperature. We exploit the adventitious amorphous carbon phase as a pore-forming agent, which is subsequently removed by selective combustion, exposing the embedded graphitic nanostructures and associated metal catalyst nanoparticles, while still retaining the macroscopic dimensions of the initial thermoset polymeric solid. The pore network formed by removal of the amorphous carbon facilitates the mass transport of gas-phase molecules, such as ammonia, to the internal surfaces of the purified carbon solid. The ability to produce nanostructured. graphitic carbons in bulk solid forms using simple processing methods will facilitate their development for applications ranging from electrochemical energy storage to gas sorption/filtration. Published by Elsevier Ltd.
C1 [Long, Jeffrey W.; Laskoski, Matthew; Keller, Teddy M.; Pettigrew, Katherine A.; Zimmerman, T'revor N.] USN, Res Lab, Div Chem, Washington, DC 20375 USA.
[Qadri, Syed B.] USN, Res Lab, Div Mat Sci & Technol, Washington, DC 20375 USA.
[Peterson, Gregory W.] USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Res & Technol Directorate,CBR Filtrat Team, Aberdeen Proving Ground, MD 21010 USA.
RP Long, JW (reprint author), USN, Res Lab, Div Chem, Code 6170, Washington, DC 20375 USA.
EM jeffrey.long@nrl.navy.mil
FU US Office of Naval Research; Defense Threat Reduction Agency
FX Financial support for this research was provided by the US Office of
Naval Research and the Defense Threat Reduction Agency. Bryan Schindler
(SAIC, Abingdon, MD) per-formed the ammonia-breakthrough measurements.
NR 45
TC 16
Z9 16
U1 3
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0008-6223
J9 CARBON
JI Carbon
PD FEB
PY 2010
VL 48
IS 2
BP 501
EP 508
DI 10.1016/j.carbon.2009.09.068
PG 8
WC Chemistry, Physical; Materials Science, Multidisciplinary
SC Chemistry; Materials Science
GA 532QK
UT WOS:000272764300025
ER
PT J
AU Martinez, O
Johnson, J
Manicassamy, B
Rong, LJ
Olinger, GG
Hensley, LE
Basler, CF
AF Martinez, Osvaldo
Johnson, Joshua
Manicassamy, Balaji
Rong, Lijun
Olinger, Gene G.
Hensley, Lisa E.
Basler, Christopher F.
TI Zaire Ebola virus entry into human dendritic cells is insensitive to
cathepsin L inhibition
SO CELLULAR MICROBIOLOGY
LA English
DT Article
ID HEMORRHAGIC-FEVER; ANTIGEN PRESENTATION; VP40 PROTEIN; GLYCOPROTEIN;
PATHOGENESIS; INFECTION; PROTEOLYSIS; MATURATION; PARTICLES; MARBURG
AB Cathepsins B and L contribute to Ebola virus (EBOV) entry into Vero cells and mouse embryonic fibroblasts. However, the role of cathepsins in EBOV-infection of human dendritic cells (DCs), important targets of infection in vivo, remains undefined. Here, EBOV-like particles containing a beta-lactamase-VP40 fusion reporter and Ebola virus were used to demonstrate the cathepsin dependence of EBOV entry into human monocyte-derived DCs. However, while DC infection is blocked by cathepsin B inhibitor, it is insensitive to cathepsin L inhibitor. Furthermore, DCs pre-treated for 48 h with TNF alpha were generally less susceptible to entry and infection by EBOV. This decrease in infection was associated with a decrease in cathepsin B activity. Thus, cathepsin L plays a minimal, if any, role in EBOV infection in human DCs. The inflammatory cytokine TNF alpha modulates cathepsin B activity and affects EBOV entry into and infection of human DCs.
C1 [Martinez, Osvaldo; Manicassamy, Balaji; Basler, Christopher F.] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA.
[Johnson, Joshua; Olinger, Gene G.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Rong, Lijun] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60607 USA.
RP Basler, CF (reprint author), Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA.
EM chris.basler@mssm.edu
OI Olinger, Gene/0000-0001-7338-0292; Martinez,
Osvaldo/0000-0001-7335-4342; Johnson, Joshua/0000-0002-5677-3841
FU NIH, (Northeast Biodefense Center-Lipkin) [U54 AI057158]; NIH [AI059536]
FX This work was supported in part by funds from the NIH, including U54
AI057158 (Northeast Biodefense Center-Lipkin) and AI059536 to C.F.B. We
would like to thank Alejandra Galvez for producing and purifying some of
the virus-like particles used in this study. Opinions, interpretations,
conclusions and recommendations are those of the authors and are not
necessarily endorsed by the US Army.
NR 39
TC 26
Z9 28
U1 0
U2 8
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1462-5814
J9 CELL MICROBIOL
JI Cell Microbiol.
PD FEB
PY 2010
VL 12
IS 2
BP 148
EP 157
DI 10.1111/j.1462-5822.2009.01385.x
PG 10
WC Cell Biology; Microbiology
SC Cell Biology; Microbiology
GA 543SX
UT WOS:000273599900003
PM 19775255
ER
PT J
AU Chun, HM
Fieberg, AM
Hullsiek, KH
Lifson, AR
Crum-Cianflone, NF
Weintrob, AC
Ganesan, A
Barthel, RV
Bradley, WP
Agan, BK
Landrum, ML
AF Chun, Helen M.
Fieberg, Ann M.
Hullsiek, Katherine Huppler
Lifson, Alan R.
Crum-Cianflone, Nancy F.
Weintrob, Amy C.
Ganesan, Anuradha
Barthel, Robert V.
Bradley, William P.
Agan, Brian K.
Landrum, Michael L.
CA HIV Working Grp
TI Epidemiology of Hepatitis B Virus Infection in a US Cohort of
HIV-Infected Individuals during the Past 20 Years
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY;
UNITED-STATES; RISK-FACTORS; C VIRUS; HEPATOTOXICITY; PREVALENCE;
RECOMMENDATIONS; ANTIBODIES; MANAGEMENT
AB Background. The epidemiologic trends of hepatitis B virus (HBV) infection in human immunodeficiency virus (HIV)-infected patients over the past 20 years are largely unknown.
Methods. Prevalence and risk factors for HBV infection overall, at the time of HIV infection, and after HIV infection were examined in an ongoing observational HIV cohort study. Risk factors for HBV infection at the time of diagnosis of HIV infection were evaluated using logistic regression, and risk of incident HBV infection after diagnosis of HIV infection was evaluated using Cox proportional hazards models.
Results. Of the 2769 evaluable participants, 1078 (39%) had HBV infection, of whom 117 (11%) had chronic HBV infection. The yearly cross-sectional prevalence of HBV infection decreased from a peak of 49% in 1995 to 36% in 2008 (P < .001). The prevalence of HBV infection at the time of diagnosis of HIV infection decreased during 1989-2008 from 34% to 9% (P < .001). The incidence of HBV infection after diagnosis of HIV infection decreased from 4.0 cases per 100 person-years during the pre-highly active antiretroviral therapy (HAART) era to 1.1 cases per 100 person-years during the HAART era (P < .001); however, this incidence remained unchanged during 2000-2008 (P = .49), with 120% of HBV infections occurring after HIV infection being chronic. Decreased risk of HBV infection after diagnosis of HIV infection was associated with higher CD4 cell count and the use of HBV-active HAART. Receipt of >= 1 dose of HBV vaccine was not associated with reduced risk of HBV infection after diagnosis of HIV infection.
Conclusions. Although the burden of HBV infection overall is slowly decreasing among HIV-infected individuals, the persistent rate of HBV infection after diagnosis of HIV infection raises concern that more-effective prevention strategies may be needed to significantly reduce the prevalence of HBV infection in this patient population.
C1 [Chun, Helen M.] Naval Hlth Res Ctr, San Diego, CA USA.
[Crum-Cianflone, Nancy F.] Naval Med Ctr San Diego, San Diego, CA USA.
[Fieberg, Ann M.; Hullsiek, Katherine Huppler; Lifson, Alan R.] Univ Minnesota, Minneapolis, MN USA.
[Fieberg, Ann M.; Hullsiek, Katherine Huppler; Lifson, Alan R.; Crum-Cianflone, Nancy F.; Weintrob, Amy C.; Ganesan, Anuradha; Bradley, William P.; Agan, Brian K.; Landrum, Michael L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA.
[Weintrob, Amy C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
[Barthel, Robert V.] Naval Med Ctr Portsmouth, Portsmouth, VA USA.
[Bradley, William P.; Landrum, Michael L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
RP Landrum, ML (reprint author), Brooke Army Med Ctr, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM mlandrum@idcrp.org
RI Marconi, Vincent/N-3210-2014;
OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669
FU Uniformed Services University of the Health Sciences (USUHS); Department
of Defence; Henry M. Jackson Foundation; National Institutes of Health,
National Institute of Allergy and Infectious Diseases [HU0001-05-2-0011]
FX Infectious Disease Clinical Research Program (IDCRP) of the Uniformed
Services University of the Health Sciences (USUHS). The IDCRP is a
Department of Defence tri-service program executed through USUHS and the
Henry M. Jackson Foundation for the Advancement of Military Medicine, in
collaboration with Health and Human Services, National Institutes of
Health, National Institute of Allergy and Infectious Diseases, Division
of Clinical Research through Interagency Agreement HU0001-05-2-0011.
NR 38
TC 28
Z9 30
U1 0
U2 1
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD FEB 1
PY 2010
VL 50
IS 3
BP 426
EP 436
DI 10.1086/649885
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 542NG
UT WOS:000273500300019
PM 20047484
ER
PT J
AU Fracisco, SD
Deye, G
House, B
Bennett, K
Stewart, A
Angov, E
Rothstein, Y
Magill, A
Ohrt, C
AF Fracisco, S. D.
Deye, G.
House, B.
Bennett, K.
Stewart, A.
Angov, E.
Rothstein, Y.
Magill, A.
Ohrt, C.
TI THE PROCESS TOWARD QUALIFICATION OF A CANDIDATE BIOMARKER, MEROZOITE
SURFACE PROTEIN-1-42 ANTIBODIES, AS A BIOMARKER IN MALARIA
CHEMOPROPHYLAXIS TRIALS.
SO CLINICAL PHARMACOLOGY & THERAPEUTICS
LA English
DT Meeting Abstract
CT 111th Annual Meeting of the
American-Society-for-Clinical-Pharmacology-and-Therapeutics
CY MAR 17-20, 2010
CL Atlanta, GA
SP Amer Soc Clin Pharmacol & Therapeut
C1 [Fracisco, S. D.; Deye, G.; Bennett, K.; Angov, E.; Rothstein, Y.; Magill, A.; Ohrt, C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[House, B.] Naval Med Res Ctr, Silver Spring, MD USA.
[Stewart, A.] Med Res Unit, Nairobi, Kenya.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0009-9236
J9 CLIN PHARMACOL THER
JI Clin. Pharmacol. Ther.
PD FEB
PY 2010
VL 87
SU 1
BP S14
EP S14
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 550PY
UT WOS:000274141600044
ER
PT J
AU Therrien, RJ
Ergut, A
Levendis, YA
Richter, H
Howard, JB
Carlson, JB
AF Therrien, Richard J.
Ergut, Ali
Levendis, Yiannis A.
Richter, Henning
Howard, Jack B.
Carlson, Joel B.
TI Investigation of critical equivalence ratio and chemical speciation in
flames of ethylbenzene-ethanol blends
SO COMBUSTION AND FLAME
LA English
DT Article
DE Soot onset; Ethanol; Ethylbenzene; Combustion; PAH; Premixed flames;
Kinetic modeling
ID POLYCYCLIC AROMATIC-HYDROCARBONS; SOOT ONSET CHEMISTRY;
ATMOSPHERIC-PRESSURE; PREMIXED FLAMES; COMBUSTION CHARACTERISTICS;
PARTICULATE-EMISSIONS; FUEL-RICH; PAH; TEMPERATURE; POLYSTYRENE
AB This work investigates five different one-dimensional, laminar, atmospheric pressure, premixed ethanol/ethylbenzene flames (0%, 25%, 50%, 75% and 90% ethanol by weight) at their soot onset threshold (phi(critical)). Liquid ethanol/ethylbenzene mixtures were pre-vaporized in nitrogen, blended with an oxygen-nitrogen mixture and, upon ignition, burned in premixed one-dimensional flames at atmospheric pressure. The flames were controlled so that each was at its visual soot onset threshold, and all had similar temperature profiles (determined by thermocouples). Fixed gases, light volatile hydrocarbons, polycyclic aromatic hydrocarbons (PAH), and oxygenated aromatic hydrocarbons were directly sampled at three locations in each flame. The experimental results were compared with a detailed kinetic model, and the modeling results were used to perform a reaction flux analysis of key species. The critical equivalence ratio was observed to increase in a parabolic fashion as ethanol concentration increased in the fuel mixture. The experimental results showed increasing trends of methane, ethane, and ethylene with increasing concentrations of ethanol in the flames. Carbon monoxide was also seen to increase significantly with the increase of ethanol in the flame, which removes carbon from the PAH and soot formation pathways. The PAH and oxygenated aromatic hydrocarbon values were very similar in the 0%, 25% and 50% ethanol flames, but significantly lower in the 75% and 90% ethanol flames. These results were in general agreement with the model and were reflected by the model soot predictions. The model predicted similar soot profiles for the 0%, 25% and 50% ethanol flames, however it predicted significantly lower values in the 75% and 90% ethanol flames. The reaction flux analysis revealed benzyl to be a major contributor to single and double ring aromatics (i.e., benzene and naphthalene), which was identified in a similar role in nearly sooting or highly sooting ethylbenzene flames. The presence of this radical was significantly reduced as ethanol concentration was increased in the flames, and this effect in combination with the lower carbon to oxygen ratios and the enhanced formation of carbon monoxide, are likely what allowed higher equivalence ratios to be reached without forming soot. (C) 2009 The Combustion Institute. Published by Elsevier Inc. All rights reserved.
C1 [Therrien, Richard J.; Ergut, Ali; Levendis, Yiannis A.] Northeastern Univ, Boston, MA 02115 USA.
[Richter, Henning; Howard, Jack B.] MIT, Cambridge, MA 02139 USA.
[Carlson, Joel B.] USA, SBCCOM, Natick Soldier Ctr, Natick, MA 01760 USA.
RP Levendis, YA (reprint author), Northeastern Univ, Boston, MA 02115 USA.
EM y.levendis@neu.edu
NR 35
TC 14
Z9 15
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0010-2180
J9 COMBUST FLAME
JI Combust. Flame
PD FEB
PY 2010
VL 157
IS 2
BP 296
EP 312
DI 10.1016/j.combustflame.2009.07.023
PG 17
WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary;
Engineering, Chemical; Engineering, Mechanical
SC Thermodynamics; Energy & Fuels; Engineering
GA 545AB
UT WOS:000273702400011
ER
PT J
AU Burke, RL
West, MW
Erwin-Cohen, R
Selby, EB
Fisher, DE
Twenhafel, NA
AF Burke, Robin L.
West, Michael W.
Erwin-Cohen, Rebecca
Selby, Edward B.
Fisher, Diana E.
Twenhafel, Nancy A.
TI Alterations in Cytokines and Effects of Dexamethasone Immunosuppression
during Subclinical Infections of Invasive Klebsiella pneumoniae with
Hypermucoviscosity Phenotype in Rhesus (Macaca mulatta) and Cynomolgus
(Macaca fascicularis) Macaques
SO COMPARATIVE MEDICINE
LA English
DT Article
ID PYOGENIC LIVER-ABSCESS; NONHUMAN-PRIMATES; BORRELIA-BURGDORFERI;
VIRULENCE FACTOR; NORTH-AMERICA; LYME-DISEASE; SEROTYPE K1; MAGA;
TAIWAN; COMMUNITY
AB Invasive Klebsiella pneumoniae with the hypermucoviscosity phenotype (HMV K. pneumoniae) is an emerging human pathogen that also has been attributed to fatal multisystemic disease in African green monkeys at our institution. Combining a cluster of subclinically infected macaques identified in March and April 2008 and the animals documented during a subsequent survey of more than 300 colony nonhuman primates yielded a total of 9 rhesus macaques and 6 cynomolgus macaques that were subclinically infected. In an attempt to propagate the responsible HMV K. pneumoniae strain, a subset of these animals was immunosuppressed with dexamethasone. None of the treated animals developed clinical disease consistent with the multisystemic disease that affected colony African green monkeys. However, cytokine analysis revealed significant alterations of secreted cytokines in macaques subclinically infected with HMV K. pneumoniae when compared with noninfected macaques, thereby calling into question the suitability of animals subclinically infected with HMV K. pneumoniae for use in immunologic or infectious disease research.
C1 [Burke, Robin L.] USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA.
[West, Michael W.; Erwin-Cohen, Rebecca] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci Div, Ft Detrick, MD 21702 USA.
[Selby, Edward B.; Fisher, Diana E.] USA, Med Res Inst Infect Dis, Div Med, Ft Detrick, MD 21702 USA.
[Twenhafel, Nancy A.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA.
RP Burke, RL (reprint author), USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA.
FU US Army Medical Research Institute of Infectious Diseases [150874]
FX The research described herein was sponsored by the US Army Medical
Research Institute of Infectious Diseases under Research Plan Number
150874
NR 55
TC 2
Z9 3
U1 2
U2 4
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1532-0820
J9 COMPARATIVE MED
JI Comparative Med.
PD FEB
PY 2010
VL 60
IS 1
BP 62
EP 70
PG 9
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 562YH
UT WOS:000275091400010
PM 20158951
ER
PT J
AU Landrum, H
Prybutok, VR
Zhang, XN
AF Landrum, Hollis
Prybutok, Victor R.
Zhang, Xiaoni
TI The moderating effect of occupation on the perception of information
services quality and success
SO COMPUTERS & INDUSTRIAL ENGINEERING
LA English
DT Article
DE Service quality; Information system success; Information quality; System
quality; Satisfaction
ID CONFIRMATORY FACTOR-ANALYSIS; SATISFACTION INSTRUMENT; USER
SATISFACTION; MCLEAN MODEL; PERFORMANCE; TECHNOLOGY; SYSTEMS;
ACCEPTANCE; EXTENSION; VALIDITY
AB Service quality represents a continual concern for practitioners and academicians. While traditional applications of SERVQUAL and SERVPERF have provided fruitful results in service quality research, these instruments are not focused on the information service area, although a number of researchers suggest that service quality be included as an information success measure. In this study, we proposed a modified IS success model that includes service quality as one of the success factors and examine occupation as a moderator of that model. We examined digital information service quality delivered in army libraries and our results contribute to the literature in several areas. We evaluate information system service quality from the perspective of occupation (technical professionals versus administrators). We examined the effect of occupation on perceptions as measured by SERVPERF and validate SERVPERF's dimensions in this environment, In addition, we assessed the moderating effect of occupation on IS success factors. Our results validated the proposed model and provided insight into the moderating effect of occupation on service quality and IS success factors. The results of this investigation provide practical implications for IS service quality because they support the need to consider service delivery based on occupation. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Zhang, Xiaoni] No Kentucky Univ, Dept Business Informat, Highland Hts, KY 41099 USA.
[Landrum, Hollis] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39183 USA.
[Prybutok, Victor R.] Univ N Texas, Coll Business Adm, Informat Technol & Decis Sci Dept, Denton, TX 76203 USA.
RP Zhang, XN (reprint author), No Kentucky Univ, Dept Business Informat, Highland Hts, KY 41099 USA.
EM hlandrum@att.net; prybutok@unt.edu; zhangx@nku.edu
OI Prybutok, Victor/0000-0003-3810-9039
NR 57
TC 8
Z9 9
U1 4
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0360-8352
J9 COMPUT IND ENG
JI Comput. Ind. Eng.
PD FEB
PY 2010
VL 58
IS 1
BP 133
EP 142
DI 10.1016/j.cie.2009.09.006
PG 10
WC Computer Science, Interdisciplinary Applications; Engineering,
Industrial
SC Computer Science; Engineering
GA 558SW
UT WOS:000274767500015
ER
PT J
AU Pidcoke, HF
Wade, CE
Mann, EA
Salinas, J
Cohee, BM
Holcomb, JB
Wolf, SE
AF Pidcoke, Heather F.
Wade, Charles E.
Mann, Elizabeth A.
Salinas, Jose
Cohee, Brian M.
Holcomb, John B.
Wolf, Steven E.
TI Anemia causes hypoglycemia in intensive care unit patients due to error
in single-channel glucometers: Methods of reducing patient risk
SO CRITICAL CARE MEDICINE
LA English
DT Article
DE glucose; insulin; anemia; point-of-care systems; hematocrit; glucose
oxidase; critical care; intensive care unit; glucometer; glucose
measurement
ID CRITICALLY-ILL PATIENTS; BLOOD-GLUCOSE MEASUREMENTS; INSULIN THERAPY;
TRANSFUSION STRATEGIES; POINT; ASSOCIATION; CAPILLARY; ACCURACY; ICU
AB Objective: Intensive insulin therapy in the critically ill reduces mortality but carries the risk of increased hypoglycemia. Point-of-care blood glucose analysis is standard; however, anemia causes falsely high values and potentially masks hypoglycemia. Permissive anemia is practiced routinely in most intensive care units. We hypothesized that point-of-care glucometer error due to anemia is prevalent, can be corrected mathematically, and correction uncovers occult hypoglycemia during intensive insulin therapy.
Design: The study has both retrospective and prospective phases. We reviewed data to verify the presence of systematic error, determine the source of error, and establish the prevalence of anemia. We confirmed our findings by reproducing the error in an in vitro model. Prospective data were used to develop a correction formula validated by the Monte Carlo method. Correction was implemented in a burn intensive care unit and results were evaluated after 9 mos.
Setting: Burn and trauma intensive care units at a single research institution.
Patients/Subjects: Samples for in vitro studies were taken from healthy volunteers. Samples for formula development were from critically ill patients who received intensive insulin therapy.
Interventions: Insulin doses were calculated based on predicted serum glucose values from corrected point-of-care glucometer measurements.
Measurements and Main Results: Time-matched point-of-care glucose, laboratory glucose, and hematocrit values. We previously found that anemia (hematocrit <34%) produces systematic error in glucometer measurements. The error was correctible with a mathematical formula developed and validated, using prospectively collected data. Error of uncorrected point-of-care glucose ranged from 19% to 29% (p < .001), improving to <= 5% after mathematical correction of prospective data. Comparison of data pairs before and after correction formula implementation demonstrated a 78% decrease in the prevalence of hypoglycemia in critically ill and anemic patients treated with insulin and tight glucose control (p < .001).
Conclusions: A mathematical formula that corrects erroneous point-of-care glucose values due to anemia in intensive care unit patients reduces the prevalence of hypoglycernia during intensive insulin therapy. (Crit Care Med 2010; 38:471-476)
C1 [Pidcoke, Heather F.; Wade, Charles E.; Mann, Elizabeth A.; Salinas, Jose; Cohee, Brian M.; Holcomb, John B.; Wolf, Steven E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Pidcoke, Heather F.; Wade, Charles E.; Holcomb, John B.; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
RP Pidcoke, HF (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM heather.pidcoke@amedd.army.mil
OI Wolf, Steven/0000-0003-2972-3440
FU NIGMS NIH HHS [1 R01 GM063120-04, R01 GM063120]
NR 29
TC 30
Z9 31
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0090-3493
J9 CRIT CARE MED
JI Crit. Care Med.
PD FEB
PY 2010
VL 38
IS 2
BP 471
EP 476
DI 10.1097/CCM.0b013e3181bc826f
PG 6
WC Critical Care Medicine
SC General & Internal Medicine
GA 547ZF
UT WOS:000273927700015
PM 19789438
ER
PT J
AU Tran, DT
Chernova, NA
Chu, D
Oliver, AG
Oliver, SRJ
AF Tran, Dat T.
Chernova, Natasha A.
Chu, Deryn
Oliver, Allen G.
Oliver, Scott R. J.
TI 3-D Metal-Organic Framework Based on Cationic 2-D Cuprate Layers:
Cu-3(OH)(4)[C10H6(SO3)(2)]
SO CRYSTAL GROWTH & DESIGN
LA English
DT Article
ID BONDED HOST FRAMEWORKS; COORDINATION POLYMERS; STRUCTURAL DIVERSITY;
NETWORKS; COMPLEXES; INCLUSION; NAPHTHALENE-2,6-DISULFONATE;
1,5-NAPHTHALENEDISULFONATE; CADMIUM(II); SEPARATION
AB We describe herein a three-dimensional Cu(II) based metal-organic framework, copper hydroxide 2,6-naphthalenedisulfonate, Cu-3(OH)(4)[C10H6(SO3)(2)]. The compound contains embedded positively charged 2-D copper oxide layers. This higher dimensionality of inorganic connectivity leads to far greater thermal stability (375 degrees C vs 245 degrees C) over our previously reported three-dimensional metal-organic framework containing embedded 1-D cuprate chains. Single crystal data for this material are as follows: FW = 544.92, monoclinic, space group P2(1)/c, a = 13.549(5) angstrom, b = 5.503(2) angstrom, c = 9.512(4) angstrom, beta = 90.031(6)degrees, V = 709.2(5) angstrom(3), D-c = 2.552 g.cm(-3), and Z = 4. The structure, crystallinity, morphology, and properties of the material are discussed. The magnetic susceptibility exhibits a broad maximum centered at 80 K, indicative of low-dimensional antiferromagnetic interactions. Control of inorganic dimensionality embedded within an MOF is an often overlooked yet key feature in determining the stability and important properties of MOFs such as adsorption, conductivity, and magnetism.
C1 [Tran, Dat T.; Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA.
[Chernova, Natasha A.] SUNY Binghamton, Inst Mat Res, Binghamton, NY 13902 USA.
[Oliver, Allen G.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA.
RP Tran, DT (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM dat.tran1@arl.army.mil
FU NSF [DMR-0506279]; U.S. Department of Energy, Office of Energy Sciences
[DEAC02-05CH11231]
FX The Army Research Laboratory is acknowledged for financial support of
this research. S.O. acknowledges financial support from an NSF Career
Award (DMR-0506279). Samples for synchrotron crystallographic analysis
were submitted through the SCrALS (Set-vice Crystallography at Advanced
Light Source) program. The ALS is supported by the U.S. Department of
Energy, Office of Energy Sciences, under Contract DEAC02-05CH11231.
NR 55
TC 14
Z9 14
U1 7
U2 62
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1528-7483
J9 CRYST GROWTH DES
JI Cryst. Growth Des.
PD FEB
PY 2010
VL 10
IS 2
BP 874
EP 879
DI 10.1021/cg901222k
PG 6
WC Chemistry, Multidisciplinary; Crystallography; Materials Science,
Multidisciplinary
SC Chemistry; Crystallography; Materials Science
GA 559PC
UT WOS:000274837000057
ER
PT J
AU Buckenmaier, C
Brandon-Edwards, H
Borden, D
Wright, J
AF Buckenmaier, Chester C., III
Brandon-Edwards, Hisani
Borden, David, Jr.
Wright, John
TI Treating Pain on the Battlefield: A Warrior's Perspective
SO CURRENT PAIN AND HEADACHE REPORTS
LA English
DT Review
DE Battlefield analgesia; Pain; Regional anesthesia; Acute pain
ID PERIPHERAL-NERVE BLOCK; ENDURING-FREEDOM; GLOBAL WAR; MANAGEMENT;
SOLDIERS; AFGHANISTAN; ANESTHESIA; CASUALTIES; ANALGESIA; TERRORISM
AB The current conflicts in Afghanistan (Operation Enduring Freedom; commenced October 2001) and Iraq (Operation Iraqi Freedom; commenced March 2003) have been remarkable due to the more than 90% survival rate among wounded warriors. Although this statistic is a historic achievement by the military's medical services, other medical issues have taken on greater emphasis as more casualties from war survive than ever before. Pain management of United States wounded, in particular, has been a medical issue of increasing importance, as modern understanding of the detrimental effects of pain on recovery and rehabilitation becomes clearer. In this review, a warrior's perspective of military pain management is explored and potential for improvement discussed.
C1 [Buckenmaier, Chester C., III; Brandon-Edwards, Hisani; Borden, David, Jr.; Wright, John] Walter Reed Army Med Ctr, Def & Vet Pain Management Initiat, Washington, DC 20307 USA.
RP Buckenmaier, C (reprint author), Walter Reed Army Med Ctr, Def & Vet Pain Management Initiat, Bldg 2,Ward 44,Room 4434, Washington, DC 20307 USA.
EM baybuck@gmail.com; hisanie@gmail.com; david.borden@usmc.mil;
john.wright@us.army.mil
FU Walter Reed Army Medical Center, Department of Anesthesia; John P.
Murtha Neuroscience and Pain Institute
FX Departmental support: Walter Reed Army Medical Center, Department of
Anesthesia. Congressional grant: John P. Murtha Neuroscience and Pain
Institute. No other potential conflicts of interest relevant to this
article were reported.
NR 26
TC 6
Z9 6
U1 0
U2 4
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1531-3433
J9 CURR PAIN HEADACHE R
JI Curr. Pain Headache Rep.
PD FEB
PY 2010
VL 14
IS 1
BP 1
EP 7
DI 10.1007/s11916-009-0090-1
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 559SC
UT WOS:000274845900001
PM 20425208
ER
PT J
AU Ely, BR
Cheuvront, SN
AF Ely, Brett R.
Cheuvront, Samuel N.
TI EFFICACY OF NUTRITIONAL ERGOGENIC AIDS IN HOT ENVIRONMENTS
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Caffeine; Carbohydrate; Endurance Performance; Heat
ID CARBOHYDRATE-ELECTROLYTE REPLACEMENT; PROLONGED EXERCISE; CAFFEINE
INGESTION; AMBIENT-TEMPERATURE; RUNNING PERFORMANCE; PERCEIVED EXERTION;
INTENSE EXERCISE; CENTRAL FATIGUE; HEAT-STRESS; TIME-TRIAL
AB Many athletes seeking a competitive edge rely on nutritional ergogenic aids to improve performance. Carbohydrate (CHO) and caffeine (CAF) supplementation appear efficacious at enhancing endurance exercise performance when studied under ideal circumstances, but the unique challenges imposed by environmental stressors such as heat may minimize or negate these effects. Similar to findings in temperate or cool environments, CHO intake during endurance exercise in hot environments produces a consistent performance benefit. But in contrast to the benefits observed in moderate environments, CAF affords no apparent performance advantage in the heat. These findings raise interesting questions about nutritional ergogenic mechanisms of action and offer direction for future research.
C1 [Cheuvront, Samuel N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA.
RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM Samuel.n.cheuvront@us.army.mil
NR 50
TC 2
Z9 2
U1 1
U2 5
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PD FEB
PY 2010
VL 8
IS 1
BP 1
EP 6
PG 6
WC Nutrition & Dietetics; Pharmacology & Pharmacy
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA 606HW
UT WOS:000278414600001
ER
PT J
AU Stetz, MC
Makela, A
Folen, R
Wiederhold, BK
AF Stetz, Melba C.
Makela, Anna
Folen, Ray
Wiederhold, Brenda K.
TI CyberStudies: Lessons from the Trenches
SO CYBERPSYCHOLOGY BEHAVIOR AND SOCIAL NETWORKING
LA English
DT Article
ID MENTAL-HEALTH; IMPACT
AB Many individuals suffer from anxiety, stress, and depression and those serving in the U. S. military are no exception. Warfighters keep returning from theater with combat stress. Several of these military service members are also technology oriented and tend to prefer performing their daily life activities with and/or near computerized systems. Fortunately, some researchers specialize in helping warfighters via gaming or virtual reality technologies. Nevertheless, a dearth of literature is published about challenges researchers face when conducting these types of studies. This article shares the experiences of a research team, under a uniformed Army Research Psychologist (Stetz), who runs research studies (a) with warfighters, (b) with technological equipment, and (c) in nonstandard laboratory settings.
C1 [Stetz, Melba C.; Makela, Anna; Folen, Ray] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Wiederhold, Brenda K.] Virtual Real Med Ctr, San Diego, CA USA.
RP Stetz, MC (reprint author), Tripler Army Med Ctr, Dept Psychol, 1 Jarrett White Rd, Tripler, HI 96859 USA.
EM melba.stetz@us.army.mil
NR 19
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2152-2715
J9 CYBERPSYCH BEH SOC N
JI Cyberpsychology Behav. Soc. Netw.
PD FEB
PY 2010
VL 13
IS 1
BP 79
EP 82
DI 10.1089/cyber.2009.0328
PG 4
WC Psychology, Social
SC Psychology
GA 601BZ
UT WOS:000278034300012
PM 20528297
ER
PT J
AU Engel, RC
Gallagher, LB
Lyle, DS
AF Engel, Rozlyn C.
Gallagher, Luke B.
Lyle, David S.
TI Military deployments and children's academic achievement: Evidence from
Department of Defense Education Activity Schools
SO ECONOMICS OF EDUCATION REVIEW
LA English
DT Article
DE Human capital
ID ABSENCES
AB Household disruptions - such as divorce, relocation, and parental absence - have long concerned researchers interested in the educational attainment of children. Here, we consider a plausible source of exogenous variation in work-related parental absences-military deployments to Iraq and Afghanistan in the 2002-2005 period. Combining the standardized test scores of children enrolled in Defense Department schools with their military parent's personnel data, we evaluate the effect of a soldier's deployment on the academic achievement of his or her children. We find that deployments have modest adverse effects in most academic subjects, with lengthy deployments and deployments during the month of testing associated with the largest detrimental effects. Evidence also suggests that these adverse effects may persist for several years. Published by Elsevier Ltd. All rights reserved.
C1 [Engel, Rozlyn C.; Gallagher, Luke B.; Lyle, David S.] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
RP Engel, RC (reprint author), US Mil Acad, Dept Social Sci, Lincoln Hall, West Point, NY 10996 USA.
EM rozlyn.engel@usma.edu
NR 6
TC 26
Z9 26
U1 2
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0272-7757
J9 ECON EDUC REV
JI Econ. Educ. Rev.
PD FEB
PY 2010
VL 29
IS 1
BP 73
EP 82
DI 10.1016/j.econedurev.2008.12.003
PG 10
WC Economics; Education & Educational Research
SC Business & Economics; Education & Educational Research
GA 560BX
UT WOS:000274877900006
ER
PT J
AU Jones, LE
Norris, WE
AF Jones, L. E.
Norris, W. E.
TI Rectal burn induced by hot coffee enema
SO ENDOSCOPY
LA English
DT Editorial Material
C1 [Jones, L. E.] Natl Naval Med Ctr, Dept Gastroenterol, Bethesda, MD 20889 USA.
[Norris, W. E.] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA.
RP Jones, LE (reprint author), Natl Naval Med Ctr, Dept Gastroenterol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM lindsay.jones2@med.navy.mil
NR 2
TC 3
Z9 4
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0013-726X
J9 ENDOSCOPY
JI Endoscopy
PD FEB
PY 2010
VL 42
SU 2
BP E26
EP E26
DI 10.1055/s-0029-1215312
PG 1
WC Gastroenterology & Hepatology; Surgery
SC Gastroenterology & Hepatology; Surgery
GA 555EE
UT WOS:000274490000015
PM 20073005
ER
PT J
AU Grim, CJ
Jaiani, E
Whitehouse, CA
Janelidze, N
Kokashvili, T
Tediashvili, M
Colwell, RR
Huq, A
AF Grim, Christopher J.
Jaiani, Ekaterina
Whitehouse, Chris A.
Janelidze, Nino
Kokashvili, Tamuna
Tediashvili, Marina
Colwell, Rita R.
Huq, Anwar
TI Detection of toxigenic Vibrio cholerae O1 in freshwater lakes of the
former Soviet Republic of Georgia
SO ENVIRONMENTAL MICROBIOLOGY REPORTS
LA English
DT Review
ID MONOCLONAL ANTIBODY; AQUATIC ENVIRONMENT; BANGLADESH
AB Three freshwater lakes, Lisi Lake, Kumisi Lake and Tbilisi Sea, near Tbilisi, Georgia, were studied from January 2006 to December 2007 to determine the presence of Vibrio cholerae employing both bacteriological culture method and direct detection methods, namely PCR and direct fluorescent antibody (DFA). For PCR, DNA extracted from water samples was tested for presence of V. cholerae and genes coding for selected virulence factors. Vibrio cholerae non-O1/non-O139 was routinely isolated by culture from all three lakes; whereas V. cholerae O1 and O139 were not. Water samples collected during the summer months from Lisi Lake and Kumisi Lake were positive for both V. cholerae and V. cholerae ctxA, tcpA, zot, ompU and toxR by PCR. Water samples collected during the same period from both Lisi and Kumisi Lake were also positive for V. cholerae serogroup O1 by DFA. All of the samples were negative for V. cholerae serotype O139. The results of this study provide evidence for an environmental presence of toxigenic V. cholerae O1, which may represent a potential source of illness as these lakes serve as recreational water in Tbilisi, Georgia.
C1 [Grim, Christopher J.; Colwell, Rita R.; Huq, Anwar] Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA.
[Grim, Christopher J.; Colwell, Rita R.] Univ Maryland, Inst Adv Comp Studies, College Pk, MD 20742 USA.
[Jaiani, Ekaterina; Janelidze, Nino; Kokashvili, Tamuna; Tediashvili, Marina] G Eliava Inst Bacteriophage Microbiol & Virol, Tbilisi, Rep of Georgia.
[Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Huq, A (reprint author), Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA.
EM huq@umd.edu
FU US Defense Threat Reduction Agency (DTRA) [GG-13]; NGA [HM15820612010]
FX The research was supported by the US Defense Threat Reduction Agency
(DTRA) CBR grant GG-13 and C.J.G. was supported by an IC Postdoctoral
Research Fellowship (NGA Grant #HM15820612010).
NR 20
TC 5
Z9 5
U1 0
U2 5
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1758-2229
J9 ENV MICROBIOL REP
JI Environ. Microbiol. Rep.
PD FEB
PY 2010
VL 2
IS 1
SI SI
BP 2
EP 6
DI 10.1111/j.1758-2229.2009.00073.x
PG 5
WC Environmental Sciences; Microbiology
SC Environmental Sciences & Ecology; Microbiology
GA 619LO
UT WOS:000279431900001
PM 23765992
ER
PT J
AU Stanley, JK
Coleman, JG
Weiss, CA
Steevens, JA
AF Stanley, Jacob K.
Coleman, Jessica G.
Weiss, Charles A., Jr.
Steevens, Jeffery A.
TI SEDIMENT TOXICITY AND BIOACCUMULATION OF NANO AND MICRON-SIZED ALUMINUM
OXIDE
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Nano; Aluminum oxide; Sediment; Toxicity; Bioaccumulation
ID HYALELLA-AZTECA; WATER; NANOPARTICLES; NANOMATERIALS
AB Nano-aluminum oxide (Al(2)O(3)) is used commercially in coatings and abrasives. Nano-Al(2)O(3) can also be generated through the oxidation of nano-aluminum in military propellants and energetics. The purpose of the present study was to assess toxicity and bioaccumulation of nano-Al(2)O(3) to a variety of sediment organisms (Tubifex tubifex, Hyalella azteca, Lumbriculus variegatus, and Corbicula fluminea). The bioaccumulation and toxicity of nano-Al(2)O(3) was compared with that of micron-sized Al(2)O(3) to investigate potential size-related effects. Results of the present study show species-specific differences in relative bioaccumulation of nano- and micron-sized Al(2)O(3). Significant toxic effects (survival and growth) were observed in H. azteca testing, but only at high concentrations unlikely to be found in the environment. Nano-Al(2)O(3) was found to be more toxic than micron-sized Al(2)O(3) to H. azteca survival in a 14-d study in which organisms were in direct contact with a thin layer of 625 or 2,500 mg of Al(2)O(3) dispersed on the surface of either sediment or sand. A significant growth effect was also observed for nano but not micron-sized Al(2)O(3) at the highest treatment level tested (100 g/kg Al(2)O(3)) in a 10-d H. azteca bioassay in which Al(2)O(3) was homogenized with sediment. However, differences in measured sediment Al concentrations (micron-sized = 55.1 [+/- 0.61 g/kg Al; nano-sized = 66.2 [+/- 0.6] g/kg Al) in the nano and micron-sized Al(2)O(3) preclude direct comparison of the toxicity of these two treatments based on particle size. Environ. Toxicol. Chem. 2010;29:422-429. (C) 2009 SETAC
C1 [Stanley, Jacob K.; Coleman, Jessica G.; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Weiss, Charles A., Jr.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
RP Stanley, JK (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM jacob.k.stanley@us.army.mil
FU U.S. Army's Environmental Quality Technology Basic Research Program
FX Permission to publish this material was granted by the Chief of
Engineers. This work was supported by the U.S. Army's Environmental
Quality Technology Basic Research Program (John Cullinane, Technical
Director). The authors thank Jennifer Bouldin and Jaimie Conrad of
Arkansas State University for collecting the C. fluminea used in the
clam bioaccumulation bioassay. We also thank Jamma Williams and Jenny
Goss of the U.S. Army Engineer Research and Development Center for
technical laboratory support.
NR 21
TC 20
Z9 26
U1 1
U2 50
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD FEB
PY 2010
VL 29
IS 2
BP 422
EP 429
DI 10.1002/etc.52
PG 8
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 552FB
UT WOS:000274272500023
PM 20821462
ER
PT J
AU Liu, MC
Akinyi, L
Scharf, D
Mo, JX
Larner, SF
Muller, U
Oli, MW
Zheng, WR
Kobeissy, F
Papa, L
Lu, XC
Dave, JR
Tortella, FC
Hayes, RL
Wang, KKW
AF Liu, Ming C.
Akinyi, Linnet
Scharf, Dancia
Mo, Jixiang
Larner, Stephen F.
Muller, Uwe
Oli, Monika W.
Zheng, Wenrong
Kobeissy, Firas
Papa, Linda
Lu, Xi-Chun
Dave, Jitendra R.
Tortella, Frank C.
Hayes, Ronald L.
Wang, Kevin K. W.
TI Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and
traumatic brain injury in rats
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE biomarker; cell death; ischemia; diagnosis; stroke; traumatic brain
injury
ID NEURON-SPECIFIC ENOLASE; ALPHA-II-SPECTRIN; FIBRILLARY ACIDIC PROTEIN;
SEVERE HEAD-INJURY; CEREBROSPINAL-FLUID; SURROGATE MARKERS;
DEUBIQUITINATING ENZYMES; OUTCOME PREDICTION; BREAKDOWN PRODUCTS; SERUM
BIOMARKER
AB Ubiquitin C-terminal hydrolase-L1 (UCH-L1), also called neuronal-specific protein gene product 9.5, is a highly abundant protein in the neuronal cell body and has been identified as a possible biomarker on the basis of a recent proteomic study. In this study, we examined whether UCH-L1 was significantly elevated in cerebrospinal fluid (CSF) following controlled cortical impact (CCI) and middle cerebral artery occlusion (MCAO; model of ischemic stroke) in rats. Quantitative immunoblots of rat CSF revealed a dramatic elevation of UCH-L1 protein 48 h after severe CCI and as early as 6 h after mild (30 min) and severe (2 h) MCAO. A sandwich enzyme-linked immunosorbent assay constructed to measure UCH-L1 sensitively and quantitatively showed that CSF UCH-L1 levels were significantly elevated as early as 2 h and up to 48 h after CCI. Similarly, UCH-L1 levels were also significantly elevated in CSF from 6 to 72 h after 30 min of MCAO and from 6 to 120 h after 2 h of MCAO. These data are comparable to the profile of the calpain-produced alpha II-spectrin breakdown product of 145 kDa biomarker. Importantly, serum UCH-L1 biomarker levels were also significantly elevated after CCI. Similarly, serum UCH-L1 levels in the 2-h MCAO group were significantly higher than those in the 30-min group. Taken together, these data from two rat models of acute brain injury strongly suggest that UCH-L1 is a candidate brain injury biomarker detectable in biofluid compartments (CSF and serum).
C1 [Liu, Ming C.; Larner, Stephen F.; Zheng, Wenrong; Hayes, Ronald L.; Wang, Kevin K. W.] Banyan Biomarkers Inc, Ctr Innovat Res, Alachua, FL 32615 USA.
[Akinyi, Linnet; Scharf, Dancia; Mo, Jixiang; Muller, Uwe; Oli, Monika W.; Hayes, Ronald L.; Wang, Kevin K. W.] Banyan Biomarkers Inc, Diagnost Res & Dev Dept, Alachua, FL 32615 USA.
[Kobeissy, Firas; Wang, Kevin K. W.] Univ Florida, Dept Psychiat, McKnight Brain Inst, Ctr Neuroprote & Biomarkers Res, Gainesville, FL 32611 USA.
[Papa, Linda] Orlando Reg Med Ctr Inc, Dept Emergency Med, Orlando, FL USA.
[Lu, Xi-Chun; Dave, Jitendra R.; Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD USA.
[Hayes, Ronald L.] Univ Florida, Dept Anesthesiol, Gainesville, FL USA.
[Wang, Kevin K. W.] Taipei Med Univ, Taipei, Taiwan.
RP Wang, KKW (reprint author), Banyan Biomarkers Inc, Ctr Innovat Res, 12085 Res Dr, Alachua, FL 32615 USA.
EM kwang@banyanbio.com
RI kobeissy, firas/E-7042-2017;
OI kobeissy, firas/0000-0002-5008-6944; Wang, Kevin/0000-0002-9343-6473
FU Department of Defense [DAMD17-03-1-0066]; NIH [R01 NS049175-01 A1,
2R44NS048685-02]; Florida State Center for Nano-Bio Sensors (CNBS) grant
FX The authors would like to acknowledge the support of Department of
Defense grant DAMD17-03-1-0066 (R. L. Hayes), NIH grants R01 NS049175-01
A1 (K. Wang) and 2R44NS048685-02 (K. K. Wang), and a Florida State
Center for Nano-Bio Sensors (CNBS) grant (K. K. Wang). This article has
been reviewed by the Walter Reed Army Institute of Research. There is no
objection to its presentation and/or publication. The opinions or
assertions contained herein are the private views of the authors and are
not to be construed as official or as reflecting the true views of the
Department of the Army or the Department of Defense. Research was
conducted in compliance with the Animal Welfare Act and other federal
statutes and regulations relating to animals and experiments involving
animals, and adheres to principles stated in the Guide for the Care and
Use of Laboratory Animals, NRC Publication, 1996 edition. K. K. Wang and
R. L. Hayes hold equity in Banyan Biomarkers, Inc., a company that
commercializes technology for detecting brain injury biomarkers.
NR 65
TC 54
Z9 58
U1 0
U2 12
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0953-816X
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD FEB
PY 2010
VL 31
IS 4
BP 722
EP 732
DI 10.1111/j.1460-9568.2010.07097.x
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 555XH
UT WOS:000274549500013
PM 20384815
ER
PT J
AU Cole, DM
Mathisen, LU
Hopkins, MA
Knapp, BR
AF Cole, David M.
Mathisen, Lillian Uthus
Hopkins, M. A.
Knapp, Byron R.
TI Normal and sliding contact experiments on gneiss
SO GRANULAR MATTER
LA English
DT Article
DE Contact mechanics; Contact stiffness; Gneiss; Experiments;
Micromechanics
ID MECHANICS
AB The development of reliable discrete element models to simulate the mechanics of granular media requires knowledge of the grain-to-grain contact laws of the material in question. We have conducted a series of normal and sliding contact experiments on material used in laboratory triaxial experiments to obtain such contact laws for DEM simulations of the experiments. The contact experiments employed segments of 14.72 mm-diameter spherical grains from the triaxial specimens and flat specimens of the same material. The spherical grains had a uniform diameter with a smooth surface finish. Monotonic and cyclic loading paths were applied in both the normal and sliding modes, and both sphere-sphere and sphere-flat contact behavior were examined. Force-displacement behavior and frictional loss were measured in all cases. The behavior was generally Hertzian in the normal contact experiments, which involved forces up to approximately 100 N. The normal contact stiffness increased from a parts per thousand 2 to 15MN m(-1) over the range of normal force examined. The sliding experiments employed several normal forces up to approximately 25 N, and produced a value of the coefficient of static friction of 0.28. The shear stiffness of the sliding contact increased with normal force, and ranged from 0.8 to 1.2MN m(-1) under normal loads ranging from a parts per thousand 1 to 7.5 N, respectively, for virgin contacts. The shear stiffness observed for the sphere-flat contact decreased with wear. Surface roughness measurements were obtained on both tested and untested regions of the spheres and flat specimens. The average roughness (Ra) for untested regions of the sphere and flat specimens were 270 and 230 nm, respectively. Repeated testing in the sliding mode reduced these values by 29-45% for the flat surfaces, and by 20% for the spherical contact. Frictional losses were observed in both the normal and sliding modes. In the sliding mode, frictional loss decreased with increasing normal load. We observed stable sliding (associated with significant contact movement under an increasing shear force) at forces that were below the macroscopic frictional limit and resulted in permanent displacement of the contact. There was generally a distinct threshold in shear force for this permanent sliding. The extent of sliding increased significantly with wear for the sphere-flat contact and was accompanied by a substantial drop in shear stiffness.
C1 [Cole, David M.; Hopkins, M. A.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA.
[Mathisen, Lillian Uthus] Kolo Veidekke AS, N-7435 Trondheim, Norway.
[Knapp, Byron R.] Profess Instruments Co, Hopkins, MN 55343 USA.
RP Cole, DM (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA.
EM David.M.Cole@usace.army.mil; Lillian.Uthus.Mathisen@veidekke.no
FU Norwegian GARAP; Norwegian Public Road Administration; Norwegian Rail
Administration; Norwegian Research Council; Norwegian Aggregate
Producers Association; Avinor; Nynas
FX Basic Research Grant entitled, "Variable-sized Ellipsoidal Discrete
Element Model of Soil Mechanical Behavior". The production cost of the
aggregate spheres was supported by the six participants of the Norwegian
GARAP (Granular Aggregates in Road and Airfield Pavements) project:
Norwegian Public Road Administration; Norwegian Rail Administration;
Norwegian Research Council; Norwegian Aggregate Producers Association;
Avinor; Nynas. We express our appreciation to Chris Williams, Bill Burch
and John Gagnon of ERDC-CRREL for their valuable contributions to the
development of the equipment and control software that made these
experiments possible.
NR 19
TC 10
Z9 10
U1 2
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1434-5021
EI 1434-7636
J9 GRANUL MATTER
JI Granul. Matter
PD FEB
PY 2010
VL 12
IS 1
BP 69
EP 86
DI 10.1007/s10035-010-0165-z
PG 18
WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied
SC Materials Science; Mechanics; Physics
GA 555VX
UT WOS:000274545500005
ER
PT J
AU Harrison, SA
AF Harrison, Stephen A.
TI Thiazolidinedione Therapy for Nonalcoholic Steatohepatitis: Go, Stop, or
Proceed with Caution?
SO HEPATOLOGY
LA English
DT Editorial Material
ID RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; FATTY
LIVER-DISEASE; METABOLIC SYNDROME; BARIATRIC SURGERY; FOLLOW-UP;
PIOGLITAZONE; ROSIGLITAZONE; RISK; ADIPONECTIN
C1 Brooke Army Med Ctr, Dept Gastroenterol, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA.
RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, Div Gastroenterol & Hepatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM stephen.harrison@amedd.army.mil
NR 24
TC 8
Z9 8
U1 0
U2 1
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD FEB
PY 2010
VL 51
IS 2
BP 366
EP 369
DI 10.1002/hep.23473
PG 4
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 550ME
UT WOS:000274131200002
PM 20101743
ER
PT J
AU Theiling, CH
Nestler, JM
AF Theiling, Charles H.
Nestler, John M.
TI River stage response to alteration of Upper Mississippi River channels,
floodplains, and watersheds
SO HYDROBIOLOGIA
LA English
DT Article; Proceedings Paper
CT 40th Annual Meeting of the Mississippi-River-Research-Consortium
CY APR 24-25, 2008
CL Dubuque, IA
SP Mississippi River Res Consortium
DE Hydrologic indicators; Predictability; Multivariate analysis; Impact
analysis; Floodplain river
ID HYDROLOGIC ALTERATION; MISSOURI RIVER; ILLINOIS RIVER; FLOOD;
ECOSYSTEMS; PREDICTABILITY; STREAMFLOW; PATTERNS; HISTORY; SYSTEM
AB The Upper Mississippi River System (UMRS) is a large and diverse river system that changes character along its 1,200 mile network of rivers and canals and 2.6 million acres of floodplain. It supports more than 30 million people in its watershed, a significant commercial waterway, more than a million acres of "floodplain" agriculture and about one-half million acres of river-floodplain managed for fish, wildlife, and recreation. Large-scale geomorphology and climate patterns largely determine the hydrologic characteristics of a nested hierarchy of UMRS river reaches. The human impacts above are also important drivers determining hydrologic characteristics within the hierarchy. Understanding the relationship among physical and chemical processes and ecological responses is critical to implement an adaptive management framework for UMRS ecosystem sustainability. Historic or contemporary data from 42 locations were used to examine changes in UMRS hydrology and to demonstrate the utility of a multiple reference condition analysis for river restoration. A multivariate mathematical framework was used to show how river stage hydrology can be characterized by the variability, predictability, seasonality, and rate of change. Large-scale "geomorphic reaches" have distinct hydrologic characteristics and response to development throughout the UMRS region, but within navigation pool hydrology is similar among all impounded reaches regardless of geomorphic reach. Reaches with hydrologic characteristics similar to historic reference conditions should be examined to determine whether those characteristics support desired management objectives. Water levels can be managed, within limits to support navigation and agriculture, to more closely resemble natural hydrology for the benefit of a variety of species, habitats, and ecological processes.
C1 [Theiling, Charles H.] USA, Corps Engineers, Rock Isl, IL 61204 USA.
[Nestler, John M.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Theiling, CH (reprint author), USA, Corps Engineers, Clock Tower Bldg,POB 2004, Rock Isl, IL 61204 USA.
EM charles.h.theiling@usace.army.mil; john.m.nestler@usace.army.mil
NR 94
TC 7
Z9 7
U1 3
U2 25
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0018-8158
J9 HYDROBIOLOGIA
JI Hydrobiologia
PD FEB
PY 2010
VL 640
IS 1
BP 17
EP 47
DI 10.1007/s10750-009-0066-5
PG 31
WC Marine & Freshwater Biology
SC Marine & Freshwater Biology
GA 546KR
UT WOS:000273810200003
ER
PT J
AU Torrieri, D
Valenti, MC
AF Torrieri, Don
Valenti, Matthew C.
TI Efficiently Decoded Full-Rate Space-Time Block Codes
SO IEEE TRANSACTIONS ON COMMUNICATIONS
LA English
DT Article
DE Space-time block codes; genetic algorithm; diversity; quasi-orthogonal
codes
ID QUASI-ORTHOGONAL STBC; PERFORMANCE ANALYSIS; COMPLEXITY; DIVERSITY
AB Space-time block codes with orthogonal structures typically provide full-diversity reception and simple receiver processing. However, rate-1 orthogonal codes for complex constellations have not been found for more than two transmit antennas. By using a genetic algorithm, rate-1 space-time block codes that accommodate very simple receiver processing at the cost of reduced diversity are designed in this paper for more than two transmit antennas. Simulation results show that evolved codes combined with efficient outer codes provide better performance over fading channels than minimum-decoding-complexity quasi-orthogonal codes at typical operating signal-to-noise ratios. When the fading is more severe than Rayleigh fading, the spectral efficiency is specified, and an efficient outer code is used, evolved codes outperform orthogonal space-time block codes.
C1 [Torrieri, Don] USA, Res Lab, Adelphi, MD USA.
[Valenti, Matthew C.] W Virginia Univ, Morgantown, WV 26506 USA.
RP Torrieri, D (reprint author), USA, Res Lab, Adelphi, MD USA.
EM dtorr@arl.army.mil; mvalenti@wvu.edu
OI Valenti, Matthew/0000-0001-6089-0509
NR 19
TC 5
Z9 5
U1 0
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0090-6778
J9 IEEE T COMMUN
JI IEEE Trans. Commun.
PD FEB
PY 2010
VL 58
IS 2
BP 480
EP 488
DI 10.1109/TCOMM.2010.02.090003
PG 9
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 578XP
UT WOS:000276330800019
ER
PT J
AU Dutta, S
Dlugosz, LS
Clayton, JW
Pool, CD
Haynes, JD
Gasser, RA
Batchelor, AH
AF Dutta, Sheetij
Dlugosz, Lisa S.
Clayton, Joshua W.
Pool, Christopher D.
Haynes, J. David
Gasser, Robert A., III
Batchelor, Adrian H.
TI Alanine Mutagenesis of the Primary Antigenic Escape Residue Cluster, C1,
of Apical Membrane Antigen 1
SO INFECTION AND IMMUNITY
LA English
DT Article
ID MALARIA VACCINE CANDIDATE; PLASMODIUM-FALCIPARUM; ANTIBODY-RESPONSE;
INHIBITORY ANTIBODY; IMMUNOGENICITY; INVASION; AMA-1; EPITOPE; GROWTH;
TRIAL
AB Antibodies against apical membrane antigen 1 (AMA1) inhibit invasion of Plasmodium merozoites into red cells, and a large number of single nucleotide polymorphisms on AMA1 allow the parasite to escape inhibitory antibodies. The availability of a crystal structure makes it possible to test protein engineering strategies to develop a monovalent broadly reactive vaccine. Previously, we showed that a linear stretch of polymorphic residues (amino acids 187 to 207), localized within the C1 cluster on domain 1, conferred the highest level of escape from inhibitory antibodies, and these were termed antigenic escape residues (AER). Here we test the hypothesis that immunodampening the C1 AER will divert the immune system toward more conserved regions. We substituted seven C1 AER of the FVO strain Plasmodium falciparum AMA1 with alanine residues (ALA). The resulting ALA protein was less immunogenic than the native protein in rabbits. Anti-ALA antibodies contained a higher proportion of cross-reactive domain 2 and domain 3 antibodies and had higher avidity than anti-FVO. No overall enhancement of cross-reactive inhibitory activity was observed when anti-FVO and anti-ALA sera were compared for their ability to inhibit invasion. Alanine mutations at the C1 AER had shifted the immune response toward cross-strain-reactive epitopes that were noninhibitory, refuting the hypothesis but confirming the importance of the C1 cluster as an inhibitory epitope. We further demonstrate that naturally occurring polymorphisms that fall within the C1 cluster can predict escape from cross-strain invasion inhibition, reinforcing the importance of the C1 cluster genotype for antigenic categorization and allelic shift analyses in future phase 2b trials.
C1 [Dutta, Sheetij; Dlugosz, Lisa S.; Clayton, Joshua W.; Pool, Christopher D.; Haynes, J. David; Gasser, Robert A., III; Batchelor, Adrian H.] Walter Reed Army Inst Res, Dept Epitope Mapping, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA.
RP Dutta, S (reprint author), Walter Reed Army Inst Res, Dept Epitope Mapping, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Sheetij.dutta@us.army.mil
FU United States Agency for International Development; Malaria Vaccine
Initiative
FX Funding for this work was provided by the Malaria Vaccine Development
Program grant (2008) from the United States Agency for International
Development and a grant from the Malaria Vaccine Initiative (2009).
NR 33
TC 12
Z9 12
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD FEB
PY 2010
VL 78
IS 2
BP 661
EP 671
DI 10.1128/IAI.00866-09
PG 11
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 546ZY
UT WOS:000273855600011
PM 19948834
ER
PT J
AU Dabisch, PA
Kline, J
Lewis, C
Yeager, J
Pitt, MLM
AF Dabisch, P. A.
Kline, J.
Lewis, C.
Yeager, J.
Pitt, M. L. M.
TI Characterization of a head-only aerosol exposure system for nonhuman
primates
SO INHALATION TOXICOLOGY
LA English
DT Article
AB A well-characterized exposure chamber is necessary to generate reproducible atmospheres for inhalation toxicology studies. The aim of the present study was to characterize a head-only exposure chamber for non-human primates. Aerosols containing bovine serum albumin (BSA) were used to characterize a 16-L dynamic airflow head-only exposure chamber. A 250-ml plastic bottle with a respirator attached located inside the chamber was used to simulate a breathing head. Chamber leak rate, mixing, and aerosol spatial distributions were quantified. The chamber concentration profile was measured at the chamber exhaust using an aerodynamic particle sizer. Aerosol spatial distribution was determined by collecting filter samples at several chamber locations. The particle size distribution was determined by collecting cascade impactor samples at several chamber locations. The estimated chamber leak rate was within standards suggested in the literature. The measured average aerosol residence time was similar to theoretical aerosol residence time, suggesting that the chamber was mixing well. Additionally, the average concentration measured at each of the sampling locations within the chamber was similar, and the within-run coefficients of variation (CV) across all sampling locations was similar to those reported in previously published studies, again suggesting that the aerosol concentration throughout the chamber was uniform. The particle size distribution was similar throughout the exposure chamber. Additionally, the BSA concentration and particle size distributions measured in the breathing zone of the simulated head were not significantly different from measurements made elsewhere in the chamber, suggesting that respiration does not affect the average aerosol concentration or particle size distribution at the mouth.