FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Crane, NJ Gillern, SM Tajkarimi, K Levin, IW Pinto, PA Elster, EA AF Crane, Nicole J. Gillern, Suzanne M. Tajkarimi, Kambiz Levin, Ira W. Pinto, Peter A. Elster, Eric A. TI Visual Enhancement of Laparoscopic Partial Nephrectomy With 3-Charge Coupled Device Camera: Assessing Intraoperative Tissue Perfusion and Vascular Anatomy by Visible Hemoglobin Spectral Response SO JOURNAL OF UROLOGY LA English DT Article DE kidney; nephrectomy; video-assisted surgery; laparoscopy; ischemia ID NEPHRON SPARING SURGERY; PATHOLOGICAL OUTCOMES; RENAL ISCHEMIA; WARM ISCHEMIA; HILAR TUMORS; SHORT-TERM; FEASIBILITY; TECHNOLOGY; IMPACT AB Purpose: We report the novel use of 3-charge coupled device camera technology to infer tissue oxygenation. The technique can aid surgeons to reliably differentiate vascular structures and noninvasively assess laparoscopic intraoperative changes in renal tissue perfusion during and after warm ischemia. Materials and Methods: We analyzed select digital video images from 10 laparoscopic partial nephrectomies for their individual 3-charge coupled device response. We enhanced surgical images by subtracting the red charge coupled device response from the blue response and overlaying the calculated image on the original image. Mean intensity values for regions of interest were compared and used to differentiate arterial and venous vasculature, and ischemic and nonischemic renal parenchyma. Results: The 3-charge coupled device enhanced images clearly delineated the vessels in all cases. Arteries were indicated by an intense red color while veins were shown in blue. Differences in mean region of interest intensity values for arteries and veins were statistically significant (p > 0.0001). Three-charge coupled device analysis of pre-clamp and post-clamp renal images revealed visible, dramatic color enhancement for ischemic vs nonischemic kidneys. Differences in the mean region of interest intensity values were also significant (p < 0.05). Conclusions: We present a simple use of conventional 3-charge coupled device camera technology in a way that may provide urological surgeons with the ability to reliably distinguish vascular structures during hilar dissection, and detect and monitor changes in renal tissue perfusion during and after warm ischemia. C1 [Crane, Nicole J.; Gillern, Suzanne M.; Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Naval Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA. [Tajkarimi, Kambiz; Pinto, Peter A.] NCI, NIH, Bethesda, MD 20892 USA. [Levin, Ira W.] NIDDKD, Chem Phys Lab, NIH, Bethesda, MD 20892 USA. [Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Gillern, Suzanne M.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Tajkarimi, Kambiz] George Washington Univ, Dept Urol, Washington, DC USA. RP Elster, EA (reprint author), Uniformed Serv Univ Hlth Sci, Naval Med Res Ctr, Dept Regenerat Med, 503 Robert Grant Ave,Suite 2W123, Silver Spring, MD 20910 USA. EM eric.elster@med.navy.mil FU United States Navy Bureau of Medicine and Surgery [PE 0604771N]; Office of Naval Research work unit [604771N.0933. 001.A0812]; Vibernet FX Supported by the United States Navy Bureau of Medicine and Surgery under the Medical Development Program (PE 0604771N), Office of Naval Research work unit No. 604771N.0933. 001.A0812, Combat Wound Initiative Program and intramural program of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.; Financial interest and/or other relationship with Vibernet. NR 29 TC 18 Z9 18 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 2010 VL 184 IS 4 BP 1279 EP 1285 DI 10.1016/j.juro.2010.06.010 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 660CB UT WOS:000282615400010 PM 20723937 ER PT J AU Geisbert, TW Bailey, M Geisbert, JB Asiedu, C Roederer, M Grazia-Pau, M Custers, J Jahrling, P Goudsmit, J Koup, R Sullivan, NJ AF Geisbert, Thomas W. Bailey, Michael Geisbert, Joan B. Asiedu, Clement Roederer, Mario Grazia-Pau, Maria Custers, Jerome Jahrling, Peter Goudsmit, Jaap Koup, Richard Sullivan, Nancy J. TI Vector Choice Determines Immunogenicity and Potency of Genetic Vaccines against Angola Marburg Virus in Nonhuman Primates SO JOURNAL OF VIROLOGY LA English DT Article ID T-CELL RESPONSES; DNA VACCINES; EBOLA-VIRUS; HEMORRHAGIC-FEVER; GUINEA-PIGS; INFECTION; PROTECTION; PATHOGENESIS; VACCINATION; HUMANS AB The immunogenicity and durability of genetic vaccines are influenced by the composition of gene inserts and choice of delivery vector. DNA vectors are a promising vaccine approach showing efficacy when combined in prime-boost regimens with recombinant protein or viral vectors, but they have shown limited comparative efficacy as a stand-alone platform in primates, due possibly to suboptimal gene expression or cell targeting. Here, regimens using DNA plasmids modified for optimal antigen expression and recombinant adenovirus (rAd) vectors, all encoding the glycoprotein (GP) gene from Angola Marburg virus (MARV), were compared for their ability to provide immune protection against lethal MARV Angola infection. Heterologous DNA-GP/rAd5-GP prime-boost and single-modality rAd5-GP, as well as the DNA-GP-only vaccine, prevented death in all vaccinated subjects after challenge with a lethal dose of MARV Angola. The DNA/DNA vaccine induced humoral responses comparable to those induced by a single inoculation with rAd5-GP, as well as CD4(+) and CD8(+) cellular immune responses, with skewing toward CD4(+) T-cell activity against MARV GP. Vaccine regimens containing rAd-GP, alone or as a boost, exhibited cellular responses with CD8(+) T-cell dominance. Across vaccine groups, CD8(+) T-cell subset dominance comprising cells exhibiting a tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma) double-positive functional phenotype was associated with an absence or low frequency of clinical symptoms, suggesting that both the magnitude and functional phenotype of CD8(+) T cells may determine vaccine efficacy against infection by MARV Angola. C1 [Bailey, Michael; Asiedu, Clement; Sullivan, Nancy J.] NIAID, Biodef Res Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Roederer, Mario; Koup, Richard] NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Geisbert, Thomas W.; Geisbert, Joan B.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Jahrling, Peter] NIAID, Integrated Res Facil, NIH, Bethesda, MD 20817 USA. [Grazia-Pau, Maria; Custers, Jerome; Goudsmit, Jaap] Crucell, NL-2333 CN Leiden, Netherlands. RP Sullivan, NJ (reprint author), NIAID, Biodef Res Sect, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM nsullivan@nih.gov NR 28 TC 33 Z9 33 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD OCT PY 2010 VL 84 IS 19 BP 10386 EP 10394 DI 10.1128/JVI.00594-10 PG 9 WC Virology SC Virology GA 660KQ UT WOS:000282641800068 PM 20660192 ER PT J AU Radoshitzky, SR Dong, LA Chi, XO Clester, JC Retterer, C Spurgers, K Kuhn, JH Sandwick, S Ruthel, G Kota, K Boltz, D Warren, T Kranzusch, PJ Whelan, SPJ Bavari, S AF Radoshitzky, Sheli R. Dong, Lian Chi, Xiaoli Clester, Jeremiah C. Retterer, Cary Spurgers, Kevin Kuhn, Jens H. Sandwick, Sarah Ruthel, Gordon Kota, Krishna Boltz, Dutch Warren, Travis Kranzusch, Philip J. Whelan, Sean P. J. Bavari, Sina TI Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin SO JOURNAL OF VIROLOGY LA English DT Article ID PROTEIN SORTING PATHWAY; HUMAN DENDRITIC CELLS; VALLEY FEVER VIRUS; EBOLA-VIRUS; MATRIX PROTEIN; NIPAH-VIRUS; SIGNAL PEPTIDE; INTERFERON RESPONSE; ZAIRE EBOLAVIRUS; IN-VITRO AB Bone marrow stromal antigen 2 (BST-2/tetherin) is a cellular membrane protein that inhibits the release of HIV-1. We show for the first time, using infectious viruses, that BST-2 also inhibits egress of arenaviruses but has no effect on filovirus replication and spread. Specifically, infectious Lassa virus (LASV) release significantly decreased or increased in human cells in which BST-2 was either stably expressed or knocked down, respectively. In contrast, replication and spread of infectious Zaire ebolavirus (ZEBOV) and Lake Victoria marburgvirus (MARV) were not affected by these conditions. Replication of infectious Rift Valley fever virus (RVFV) and cowpox virus (CPXV) was also not affected by BST-2 expression. Elevated cellular levels of human or murine BST-2 inhibited the release of virus-like particles (VLPs) consisting of the matrix proteins of multiple highly virulent NIAID Priority Pathogens, including arenaviruses (LASV and Machupo virus [MACV]), filoviruses (ZEBOV and MARV), and paramyxoviruses (Nipah virus). Although the glycoproteins of filoviruses counteracted the antiviral activity of BST-2 in the context of VLPs, they could not rescue arenaviral (LASV and MACV) VLP release upon BST-2 overexpression. Furthermore, we did not observe colocalization of filoviral glycoproteins with BST-2 during infection with authentic viruses. None of the arenavirus-encoded proteins rescued budding of VLPs in the presence of BST-2. Our results demonstrate that BST-2 might be a broad antiviral factor with the ability to restrict release of a wide variety of human pathogens. However, at least filoviruses, RVFV, and CPXV are immune to its inhibitory effect. C1 [Radoshitzky, Sheli R.; Dong, Lian; Chi, Xiaoli; Clester, Jeremiah C.; Retterer, Cary; Spurgers, Kevin; Sandwick, Sarah; Ruthel, Gordon; Kota, Krishna; Boltz, Dutch; Warren, Travis; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. [Kuhn, Jens H.] Tunnell Consulting, King Of Prussia, PA 19406 USA. [Kranzusch, Philip J.; Whelan, Sean P. J.] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St,Natl Interagency Biodef Campus, Frederick, MD 21702 USA. EM sina.bavari@amedd.army.mil RI Kuhn, Jens H./B-7615-2011 OI Kuhn, Jens H./0000-0002-7800-6045 FU Joint Science and Technology Office for Chemical and Biological Defense [4.10022_08_RD_B] FX Work performed at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) was supported by grant 4.10022_08_RD_B from the Joint Science and Technology Office for Chemical and Biological Defense. NR 66 TC 74 Z9 78 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD OCT PY 2010 VL 84 IS 20 BP 10569 EP 10580 DI 10.1128/JVI.00103-10 PG 12 WC Virology SC Virology GA 660KW UT WOS:000282642600013 PM 20686043 ER PT J AU Halstead, SB Mahalingam, S Marovich, MA Ubol, S Mosser, DM AF Halstead, Scott B. Mahalingam, Suresh Marovich, Mary A. Ubol, Sukathida Mosser, David M. TI Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes SO LANCET INFECTIOUS DISEASES LA English DT Review ID DENGUE VIRUS-INFECTION; FC-GAMMA RECEPTORS; EXPERIMENTAL VISCERAL LEISHMANIASIS; ROSS RIVER VIRUS; HEMORRHAGIC-FEVER; PERITONITIS VIRUS; ALEUTIAN DISEASE; INTERFERON-GAMMA; T-CELLS; MYCOBACTERIUM-TUBERCULOSIS AB A wide range of microorganisms can replicate in macrophages, and cell entry of these pathogens via non-neutralising IgG antibody complexes can result in increased intracellular infection through idiosyncratic Fey-receptor signalling. The activation of Fc gamma receptors usually leads to phagocytosis. Paradoxically, the ligation of monocyte or macrophage Fey receptors by IgG immune complexes, rather than aiding host defences, can suppress innate immunity, increase production of interleulcin 10, and bias T-helper-1 (Th1) responses to Th2 responses, leading to increased infectious output by infected cells. This intrinsic antibody-dependent enhancement (ADE) of infection modulates the severity of diseases as disparate as dengue haemorrhagic fever and leishmaniasis. Intrinsic ADE is distinct from extrinsic ADE, whereby complexes of infectious agents with non-neutralising antibodies lead to an increased number of infected cells. Intrinsic ADE might be involved in many protozoan, bacterial, and viral infections. We review insights into intracellular mechanisms and implications of enhanced pathogenesis after ligation of macrophage Fey receptors by infectious immune complexes. C1 [Mahalingam, Suresh] Univ Canberra, Fac Sci Appl, Canberra, ACT 2601, Australia. [Marovich, Mary A.] Walter Reed Army Inst Res, Dept Vaccine Res & Dev, Rockville, MD USA. [Ubol, Sukathida] Mahidol Univ, Dept Microbiol, Bangkok 10700, Thailand. [Mosser, David M.] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA. [Halstead, Scott B.] Int Vaccine Inst, Support Res & Dev Program, Seoul, South Korea. RP Halstead, SB (reprint author), 5824 Edson Lane N, Bethesda, MD 20852 USA. EM halsteads@erols.com RI Mosser, David/I-6697-2016 OI Mosser, David/0000-0002-9503-4187 FU NIAID NIH HHS [R01 AI049383, R01 AI049383-10] NR 123 TC 147 Z9 158 U1 1 U2 21 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1473-3099 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD OCT PY 2010 VL 10 IS 10 BP 712 EP 722 DI 10.1016/S1473-3099(10)70166-3 PG 11 WC Infectious Diseases SC Infectious Diseases GA 663SW UT WOS:000282911200019 PM 20883967 ER PT J AU Littlefield, PD Vujanovic, I Mundi, J Matic, AI Richter, CP AF Littlefield, Philip D. Vujanovic, Irena Mundi, Jagmeet Matic, Agnella Izzo Richter, Claus-Peter TI Laser Stimulation of Single Auditory Nerve Fibers SO LARYNGOSCOPE LA English DT Article DE Cochlear implant; neuroprosthesis; optical stimulation; spatial selectivity; spiral ganglion cell ID MULTICHANNEL ELECTRICAL-STIMULATION; COCHLEAR IMPLANT; SPEECH-PERCEPTION; PULSE TRAINS; OPTICAL STIMULATION; RESPONSE PROPERTIES; EXCITATION; PATTERNS; CAT; FREQUENCY AB Objectives/Hypothesis: One limitation with cochlear implants is the difficulty stimulating spatially discrete spiral ganglion cell groups because of electrode interactions. Multipolar electrodes have improved on this some, but also at the cost of much higher device power consumption. Recently, it has been shown that spatially selective stimulation of the auditory nerve is possible with a mid-infrared laser aimed at the spiral ganglion via the round window. However, these neurons must be driven at adequate rates for optical radiation to be useful in cochlear implants. We herein use single-fiber recordings to characterize the responses of auditory neurons to optical radiation. Study Design: In vivo study using normal-hearing adult gerbils. Methods: Two diode lasers were used for stimulation of the auditory nerve. They operated between 1.844 mu m and 1.873 mu m, with pulse durations of 35 mu s to 1,000 mu s, and at repetition rates up to 1,000 pulses per second (pps). The laser outputs were coupled to a 200-mu m-diameter optical fiber placed against the round window membrane and oriented toward the spiral ganglion. The auditory nerve was exposed through a craniotomy, and recordings were taken from single fibers during acoustic and laser stimulation. Results: Action potentials occurred 2.5 ms to 4.0 ms after the laser pulse. The latency jitter was up to 3 ms. Maximum rates of discharge averaged 97 +/- 52.5 action potentials per second. The neurons did not strictly respond to the laser at stimulation rates over 100 pps. Conclusions: Auditory neurons can be stimulated by a laser beam passing through the round window membrane and driven at rates sufficient for useful auditory information. Optical stimulation and electrical stimulation have different characteristics; which could be selectively exploited in future cochlear implants. C1 [Littlefield, Philip D.] Walter Reed Army Med Ctr, ENT Sect, Dept Surg, Washington, DC 20307 USA. [Littlefield, Philip D.; Vujanovic, Irena; Mundi, Jagmeet; Matic, Agnella Izzo; Richter, Claus-Peter] Northwestern Univ, Feinberg Med Sch, Dept Otolaryngol, Chicago, IL 60611 USA. [Richter, Claus-Peter] Northwestern Univ, Dept Biomed Engn, Hugh Knowles Ctr, Evanston, IL 60208 USA. [Richter, Claus-Peter] Northwestern Univ, Dept Commun Sci & Disorders, Hugh Knowles Ctr, Evanston, IL USA. RP Littlefield, PD (reprint author), Walter Reed Army Med Ctr, ENT Sect, Dept Surg, Bldg 2,6900 Georgia Ave NW, Washington, DC 20307 USA. EM Hawaiiear@mac.com OI Littlefield, Philip/0000-0002-1890-2278 FU National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Department of Health and Human Services [HHSN260-2006-00006-C/NIH, N01-DC-6-0006]; NIH [R41 DC008515-01, F31 DC008246-01]; Capita Foundation; Lockheed Martin Aculight FX This project has been funded in whole or in part with federal funds from the National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN260-2006-00006-C/NIH No. N01-DC-6-0006, by NIH Grants R41 DC008515-01 and F31 DC008246-01, and the Capita Foundation.; C.-P. R. and A. I. M. have patents using laser stimulation technology and are partially funded by Lockheed Martin Aculight. NR 49 TC 24 Z9 25 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD OCT PY 2010 VL 120 IS 10 BP 2071 EP 2082 DI 10.1002/lary.21102 PG 12 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 661QP UT WOS:000282743100028 PM 20830761 ER PT J AU Connelly, S Ruark, G AF Connelly, Shane Ruark, Gregory TI Leadership style and activating potential moderators of the relationships among leader emotional displays and outcomes SO LEADERSHIP QUARTERLY LA English DT Article DE Transformational and transactional leadership; Leader emotion displays; Follower performance; Follower evaluations of leader ID BUSINESS-UNIT PERFORMANCE; TRANSFORMATIONAL LEADERSHIP; CHARISMATIC LEADERSHIP; TRANSACTIONAL LEADERSHIP; DISCRETE EMOTIONS; POSITIVE AFFECT; NEGATIVE AFFECT; SUBORDINATE ATTITUDES; MOOD LINKAGE; BEHAVIOR AB The present study argues that leader emotional displays are important to consider both within and outside of transformational/charismatic paradigms and must look beyond positive and negative affect. Accordingly, this experiment examined the effects of emotion valence as moderated by leadership style (transformational vs. transactional) and activating potential (high vs. low) on follower satisfaction, evaluations of the leader, and creative task performance. Findings showed differential effects of positive and negative emotions for different leader styles for evaluations of transformational leadership and leader effectiveness and for follower performance. Additionally, positive emotions with higher-activating potential resulted in more desirable outcomes than those lower in activating potential, but the reverse was true for negative emotions. Findings are discussed in light of research and practical implications. (C) 2010 Elsevier Inc. All rights reserved. C1 [Connelly, Shane] Univ Oklahoma, Norman, OK 73019 USA. [Ruark, Gregory] USA, Res Inst, Washington, DC USA. RP Connelly, S (reprint author), Univ Oklahoma, Norman, OK 73019 USA. EM sconnelly@ou.edu NR 137 TC 25 Z9 28 U1 4 U2 24 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 J9 LEADERSHIP QUART JI Leadersh. Q. PD OCT PY 2010 VL 21 IS 5 BP 745 EP 764 DI 10.1016/j.leaqua.2010.07.005 PG 20 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 677UY UT WOS:000284018600005 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Hitler's Master of the Dark Arts: Himmler's Black Knights and the Occult Origins of the SS. SO LIBRARY JOURNAL LA English DT Book Review C1 Dallas Publ Lib, Dallas, TX USA. [Burgess, Edwin B.] Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 2010 VL 135 IS 16 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 662UP UT WOS:000282839500154 ER PT J AU Frew, DJ Akers, SA Chen, W Green, ML AF Frew, D. J. Akers, S. A. Chen, W. Green, Mark L. TI Development of a dynamic triaxial Kolsky bar SO MEASUREMENT SCIENCE AND TECHNOLOGY LA English DT Article DE Kolsky bar; triaxial test; dynamic loading; high strain rate ID HOPKINSON PRESSURE BAR; PULSE SHAPING TECHNIQUES; STRAIN RATES; MULTIAXIAL-COMPRESSION; STRENGTH; CONFINEMENT; BEHAVIOR; TEMPERATURE; PENETRATION; MECHANICS AB We present a confined Kolsky bar device capable of applying hydrostatic confining pressures and dynamic axial shear loads to right-circular cylindrical samples. The conventional Kolsky bar apparatus is modified by adding a high-pressure hydraulic chamber capable of applying radial confining pressures up to 400 MPa to the test specimen. An additional pressure chamber is added to the free end of the transmission bar and applies the axial portion of the hydrostatic pressure to the specimen. Once confinement is achieved, a striker bar impacts the incident bar to apply a dynamic, axial shear load to the test specimen. Pulse shaping techniques are employed in this device to generate the desired incident pulse necessary to achieve stress equilibrium in the sample and strain the sample at a nearly constant rate. We present data for an Indiana limestone tested at confining pressures up to 200 MPa and strain rates of 400 s(-1), and compare results to quasi-static data. C1 [Frew, D. J.] Dynam Syst & Res Inc, Albuquerque, NM 87110 USA. [Akers, S. A.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Chen, W.] Purdue Univ, Sch Aeronaut, W Lafayette, IN 47907 USA. [Chen, W.] Purdue Univ, Sch Astronaut & Mat Engn, W Lafayette, IN 47907 USA. [Green, Mark L.] USAF, Res Lab, Dept AF, Eglin AFB, FL 32542 USA. RP Frew, DJ (reprint author), Dynam Syst & Res Inc, Albuquerque, NM 87110 USA. EM djfrew@dsr.us.com FU US Army Laboratory Director's Research and Development (LDRD); Military Engineering Basic Research [AT22-WP255] FX A US Army facility at the Engineering Research and Development Center, Waterways Experiment Station, in Vicksburg, MS developed and used in the execution of this work and was supported under a US Army Laboratory Director's Research and Development (LDRD) program and under a Military Engineering Basic Research program (AT22-WP255). Permission to publish was granted by Director, Geotechnical and Structures Laboratory, ERDC. NR 52 TC 9 Z9 11 U1 2 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-0233 EI 1361-6501 J9 MEAS SCI TECHNOL JI Meas. Sci. Technol. PD OCT PY 2010 VL 21 IS 10 AR 105704 DI 10.1088/0957-0233/21/10/105704 PG 10 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 649QG UT WOS:000281787100048 ER PT J AU Yu, AB Zacks, JM AF Yu, Alfred B. Zacks, Jeffrey M. TI The role of animacy in spatial transformations SO MEMORY & COGNITION LA English DT Article ID MENTAL ROTATION; PERSPECTIVE-TAKING; MAGNETIC STIMULATION; BODY; OBJECTS; BODIES; VIEWER; FMRI AB We present evidence that different mental spatial transformations are used to reason about three different types of items representing a spectrum of animacy: human bodies, nonhuman animals, and inanimate objects. Participants made two different judgments about rotated figures: handedness judgments ("Is this the left or right side?") and matching judgments ("Are these figures the same?"). Perspective-taking strategies were most prevalent when participants made handedness judgments about human bodies and animals. In contrast, participants generally did not imagine changes in perspective to perform matching judgments. Such results suggest that high-level information about semantic categories, including information about a thing's animacy, can influence how spatial representations are transformed when performing online problem solving. Supplemental materials for this article may be downloaded from http://mc.psychonomic-journals.org/content/supplemental. C1 [Yu, Alfred B.] Washington Univ, Dept Psychol, St Louis, MO 63130 USA. [Yu, Alfred B.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Yu, AB (reprint author), Washington Univ, Dept Psychol, St Louis, MO 63130 USA. EM alfredyu@wustl.edu RI Zacks, Jeffrey/E-9099-2011 OI Zacks, Jeffrey/0000-0003-1171-3690 NR 41 TC 9 Z9 9 U1 2 U2 6 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 USA SN 0090-502X J9 MEM COGNITION JI Mem. Cogn. PD OCT PY 2010 VL 38 IS 7 BP 982 EP 993 DI 10.3758/MC.38.7.982 PG 12 WC Psychology, Experimental SC Psychology GA 670WG UT WOS:000283457400014 PM 20921110 ER PT J AU Yasuda, T Abe, T Brechue, WF Iida, H Takano, H Meguro, K Kurano, M Fujita, S Nakajima, T AF Yasuda, Tomohiro Abe, Takashi Brechue, William F. Iida, Haruko Takano, Haruhito Meguro, Kentaro Kurano, Miwa Fujita, Satoshi Nakajima, Toshiaki TI Venous blood gas and metabolite response to low-intensity muscle contractions with external limb compression SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article ID HUMAN SKELETAL-MUSCLE; RESISTANCE EXERCISE; VASCULAR OCCLUSION; HANDGRIP EXERCISE; GROUP-III; FLOW; STRENGTH; FATIGUE; LACTATE; RESTRICTION AB The effect of low-intensity resistance exercise with external limb compression (100 [EC 1001 and 160 [EC I 60] mm Hg) on limb blood flow and venous blood gas-metabolite response was investigated and compared with that of high-intensity resistance exercise (no external compression). Unilateral elbow flexion muscle contractions were performed at 20% (75 repetitions, 4 sets, 30-second rest intervals) and 70% of 1-repetition maximum (1-RM; 3 sets, each set was until failure, 3-minute rest intervals). Precontraction brachial arterial blood flow (Doppler ultrasound) was reduced with EC100 or EC160 (56% and 39% of baseline value, respectively) compared with no external compression (control). At 20% 1-RM, brachial arterial blood flow increased after contractions performed with EC160 (190%), but not with the others. Decreases in venous oxygen partial pressure (P(v)O(2)) and venous oxygen saturation (S(v)O(2)) were greater during EC100 and EC160 than control (mean [SE]: P(v)O(2), 28 [3] vs 26 [2] vs 33 [2] mm Hg; S(v)O(2), 41% [5%] vs 34% [4%] vs 52% [5%], respectively). Changes in venous pH (pH(v)), venous carbon dioxide partial pressure (P(v)CO(2)), and venous lactate concentration ([L(-)](v)) were greater with EC160 than EC100 and/or control (pH(v) 7.19 [0.01] vs 7.25 [0.01] vs 7.27 [0.02]; P(v)CO(2), 72 [3] vs 64 [2] vs 60 [3] mm [L(-)](v), 5.4 [0.6] vs 3.7 [0.4] vs 3.0 [0.4] mmol/L, respectively). Seventy percent 1-RM contractions resulted in greater changes in pH(v) (7.14 [0.02]), P(v)CO(2) (91 [5] mm Hg), and [L(-)](v) (7.0 [0.5] mmol/L) than EC100 and EC160, but P(v)O(2) (30 [4] mm Hg) and S(v)O(2) (40% [3%]) were similar. In conclusion, changes in pH(v), P(v)CO(2), and [L(-)](v), but not in P(v)O(2) and S(v)O(2), are sensitive to changes in relative, "internal" intensity of low-intensity muscle contractions caused by reduced blood flow (EC160) or high-intensity muscle contractions. Given the magnitude of the changes in pH(v), P(v)CO(2), and [L(-)](v), it appears plausible that they may be involved in stimulating the observed increase in muscle activation via group III and IV afferents. (C) 2010 Elsevier Inc. All rights reserved. C1 [Yasuda, Tomohiro; Iida, Haruko; Takano, Haruhito; Meguro, Kentaro; Kurano, Miwa; Nakajima, Toshiaki] Univ Tokyo, Grad Sch Med, Dept Ischem Circulatory Physiol, Tokyo, Japan. [Yasuda, Tomohiro; Abe, Takashi; Fujita, Satoshi] Univ Tokyo, Grad Sch Frontier Sci, Inst Environm Studies, Chiba, Japan. [Brechue, William F.] US Mil Acad, Ctr Phys Dev Excellence, West Point, NY 10996 USA. RP Yasuda, T (reprint author), Univ Tokyo, Grad Sch Med, Dept Ischem Circulatory Physiol, Tokyo, Japan. EM yasuda@h.k.u-tokyo.ac.jp NR 46 TC 43 Z9 43 U1 4 U2 10 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0026-0495 J9 METABOLISM JI Metab.-Clin. Exp. PD OCT PY 2010 VL 59 IS 10 BP 1510 EP 1519 DI 10.1016/j.metabol.2010.01.016 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 656YG UT WOS:000282376400017 PM 20199783 ER PT J AU Killgore, WDS Castro, CA Hoge, CW AF Killgore, William D. S. Castro, Carl A. Hoge, Charles W. TI Preliminary Normative Data for the Evaluation of Risks Scale-Bubble Sheet Version (EVAR-B) for Large-Scale Surveys of Returning Combat Veterans SO MILITARY MEDICINE LA English DT Article ID SLEEP-DEPRIVATION; TAKING BEHAVIORS; DECISION-MAKING; PERSIAN-GULF; PROPENSITY; DEPLOYMENT; EXPERIENCES; MORTALITY; PERSONNEL; VALIDITY AB Objective: The Evaluation of Risks (EVAR) scale has been used to assess risk-taking propensity in military samples. This report provides preliminary reliability, validity, and normative data on a modified version of the instrument designed to facilitate data entry with optical scanners, the Evaluation of Risks-Bubble Sheet version (EVAR-B). Methods: 2,015 U.S. Army soldiers completed the EVAR-B and a survey assessing risk-related behaviors 3 months after returning home from combat deployment in Iraq. Results: EVAR-B demonstrated acceptable internal consistency and reliability and correlated significantly with independent measures of self-reported risk-taking behavior, including alcohol use and aggressive behavior, in the weeks preceding the survey. Tentative cut-offs significantly differentiated heavy drinkers, dangerous drivers, and soldiers reporting recent aggressive outbursts. Normative data are provided for comparison with future studies. Conclusions: The EVAR-B is a reliable and valid measure of risk-taking propensity, which provides enhanced flexibility for administration and scoring in large surveys and field environments. C1 [Killgore, William D. S.; Castro, Carl A.; Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Killgore, William D. S.] Harvard Univ, Neuroimaging Ctr, McLean Hosp, Sch Med, Belmont, MA 02478 USA. [Castro, Carl A.] USA, Med Res & Mat Command, Mil Operat Med Res Program, Ft Detrick, MD 21702 USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. OI Killgore, William/0000-0002-5328-0208 FU U.S. Army Medical Research and Materiel Command FX This work was funded by the U.S. Army Medical Research and Materiel Command. NR 21 TC 1 Z9 1 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2010 VL 175 IS 10 BP 725 EP 731 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 658CX UT WOS:000282468500006 PM 20968261 ER PT J AU Smith, TJ Margolis, LM Young, AJ AF Smith, Tracey J. Margolis, Lee M. Young, Andrew J. TI Should Military Dining Facilities Offer and Promote Consumption of Probiotic-Containing Foods? SO MILITARY MEDICINE LA English DT Article ID PLACEBO-CONTROLLED-TRIAL; IRRITABLE-BOWEL-SYNDROME; SALIVARY MUTANS STREPTOCOCCI; LACTOBACILLUS-RHAMNOSUS GR-1; JAPANESE CEDAR POLLINOSIS; ACIDOPHILUS STRAIN L-92; RANDOMIZED DOUBLE-BLIND; SELF-REPORTED INCIDENCE; COMMON COLD EPISODES; BACTERIAL VAGINOSIS AB Probiotics are defined as "live organisms which, when administered in adequate amounts confer a benefit on the host." The purpose of this review was to determine whether there is evidence-based justification to recommend purchase and promotion of probiotic-containing food in military dining facilities (DFACs). Peer-reviewed literature was searched to identify well-conducted systematic reviews and original research related to the efficacy of probiotics in preventing and/or treating acute infectious diarrhea, irritable bowel syndrome, respiratory tract infections, allergic rhinitis, dental health issues, and female urogenital conditions. Probiotics may be useful for preventing and/or treating military-relevant health conditions. However, the available scientific evidence is not sufficient to warrant widespread procurement and promotion of probiotic-containing food items in military DFACs. Health care practitioners considering recommending probiotics should understand that health effects and clinical outcomes discussed herein are specific to the probiotic strain, dose, and method of delivery studied in the articles cited. C1 [Smith, Tracey J.; Margolis, Lee M.; Young, Andrew J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Smith, TJ (reprint author), USA, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. FU Medical Research and Materiel Command FX The authors acknowledge the editorial comments provided by Dr. Mary Ellen Sanders. This project was funded by the Medical Research and Materiel Command. NR 78 TC 1 Z9 1 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2010 VL 175 IS 10 BP 770 EP 783 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA 658CX UT WOS:000282468500013 PM 20968268 ER PT J AU Wall, WA Douglas, NA Xiang, QY Hoffmann, WA Wentworth, TR Hohmann, MG AF Wall, Wade A. Douglas, Norman A. Xiang, Qiu-Yun (Jenny) Hoffmann, William A. Wentworth, Thomas R. Hohmann, Matthew G. TI Evidence for range stasis during the latter Pleistocene for the Atlantic Coastal Plain endemic genus, Pyxidanthera Michaux SO MOLECULAR ECOLOGY LA English DT Article DE amplified fragment length polymorphism; cpDNA; Diapensiaceae; phylogeography; Pleistocene; refugium ID FRAGMENT LENGTH POLYMORPHISM; EASTERN NORTH-AMERICA; CHLOROPLAST DNA-SEQUENCES; MULTILOCUS GENOTYPE DATA; POPULATION-STRUCTURE; COMPARATIVE PHYLOGEOGRAPHY; GENETIC DIFFERENTIATION; ALLOZYME VARIATION; STATISTICAL TESTS; NEW-JERSEY AB The general phylogeographical paradigm for eastern North America (ENA) is that many plant and animal species retreated into southern refugia during the last glacial period, then expanded northward after the last glacial maximum (LGM). However, some taxa of the Gulf and Atlantic Coastal Plain (GACP) demonstrate complex yet recurrent distributional patterns that cannot be explained by this model. For example, eight co-occurring endemic plant taxa with ranges from New York to South Carolina exhibit a large disjunction separating northern and southern populations by > 300 km. Pyxidanthera (Diapensiaceae), a plant genus that exhibits this pattern, consists of two taxa recognized as either species or varieties. We investigated the taxonomy and phylogeography of Pyxidanthera using morphological data, cpDNA sequences, and amplified fragment length polymorphism markers. Morphological characters thought to be important in distinguishing Pyxidanthera barbulata and P. brevifolia demonstrate substantial overlap with no clear discontinuities. Genetic differentiation is minimal and diversity estimates for northern and southern populations of Pxyidanthera are similar, with no decrease in rare alleles in northern populations. In addition, the northern populations harbour several unique cpDNA haplotypes. Pyxidanthera appears to consist of one morphologically variable species that persisted in or near its present range at least through the latter Pleistocene, while the vicariance of the northern and southern populations may be comparatively recent. This work demonstrates that the refugial paradigm is not always appropriate and GACP endemic plants, in particular, may exhibit phylogeographical patterns qualitatively different from those of other ENA plant species. C1 [Wall, Wade A.; Douglas, Norman A.; Xiang, Qiu-Yun (Jenny); Hoffmann, William A.; Wentworth, Thomas R.] N Carolina State Univ, Dept Plant Biol, Raleigh, NC 27695 USA. [Hohmann, Matthew G.] USA, Corps Engineers, Engn Res & Dev Ctr, Champaign, IL 61826 USA. RP Wall, WA (reprint author), N Carolina State Univ, Dept Plant Biol, Box 7612, Raleigh, NC 27695 USA. EM wade.wall@gmail.com RI Hoffmann, William/E-8894-2010 OI Hoffmann, William/0000-0002-1926-823X FU Construction Engineering Research Laboratory [W9132T-07-2-0019]; Native Plant Society FX We thank Fort Bragg Military Reservation and the Endangered Species Branch for logistic support and the Construction Engineering Research Laboratory (US Army Corps of Engineers Agreement #W9132T-07-2-0019) and the Native Plant Society for funding. We also thank the following individuals and laboratories for assistance: Consuelo Arellano, Ignazio Carbone, Matthew Cleary, Emile Devito, Janet Gray, Jacob Hilton, Xiang Liu, Bert Pittman, Bruce Sorrie, Andrew Walker, Alan Weakley, Steve Young and the Xiang and Hoffmann labs. NR 90 TC 10 Z9 10 U1 1 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1083 EI 1365-294X J9 MOL ECOL JI Mol. Ecol. PD OCT PY 2010 VL 19 IS 19 BP 4302 EP 4314 DI 10.1111/j.1365-294X.2010.04793.x PG 13 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA 654PM UT WOS:000282180500019 PM 20819166 ER PT J AU Fitzpatrick, KF AF Fitzpatrick, Kevin F. TI REFERENCE DATA FOR COMMONLY USED SENSORY AND MOTOR NERVE CONDUCTION STUDIES SO MUSCLE & NERVE LA English DT Letter C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Fitzpatrick, KF (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0148-639X J9 MUSCLE NERVE JI Muscle Nerve PD OCT PY 2010 VL 42 IS 4 BP 614 EP 614 DI 10.1002/Mus.21804 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 658KC UT WOS:000282487900025 PM 20740632 ER PT J AU Rajabalinejad, M Demirbilek, Z Mahdi, T AF Rajabalinejad, Mohammadreza Demirbilek, Zeki Mahdi, Tewfik TI Determination of failure probabilities of flood defence systems with improved dynamic bounds method SO NATURAL HAZARDS LA English DT Article DE Reliability; Monte Carlo; Dynamic bounds; Flood defence; Monotonic; Simulations AB In this paper, we describe the computational framework of a novel method for solving the challenging problem of probabilistic finite elements. The method is called Improved Dynamic Bounds (IDB) and was developed recently to improve the efficiency of the dynamic bounds. The IDB is used in finite element numerical models to calculate time-dependent failure analyses of structures. In applications, the IDB can speed up the overall simulation process by several orders of magnitude. In applications controlled by two influential variables (e.g, two-dimensional problem), the computational efficiency is improved by a factor of 769 according to Rajabalinejad (2009). Applications of IDB indicate the method is most efficient for problems where the number of influential variables are limited. This is often the case for geotechnical and coastal flood defence systems. The IDB method is applied in this paper to the 17th Street Flood Wall, a component of the flood defence system (levee infra-structure) that failed during the Hurricane Katrina, to calculate the failure probability of an I-wall. C1 [Rajabalinejad, Mohammadreza; Mahdi, Tewfik] Ecole Polytech, Dept Civil Geol & Min Engn, Montreal, PQ H3C 3A7, Canada. [Demirbilek, Zeki] USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. RP Rajabalinejad, M (reprint author), Ecole Polytech, Dept Civil Geol & Min Engn, Stn Ctr Ville,POB 6079, Montreal, PQ H3C 3A7, Canada. EM M.Rajabalinejad@polymtl.ca RI Rajabalinejad, Mohammadreza/B-8709-2008 FU NavSys Program FX The information used in this research for the 17th Street Flood Wall project was obtained from various publications available on Internet and study reports downloaded from different Web sites. ZD was supported by the NavSys Program during this research and would like to thank Program Managers Jeff Lillycrop and Eddie Wiggins for their support. Permission to publish this information was granted by the Chief, U.S. Army Corps of Engineers. NR 16 TC 6 Z9 6 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X J9 NAT HAZARDS JI Nat. Hazards PD OCT PY 2010 VL 55 IS 1 BP 95 EP 109 DI 10.1007/s11069-010-9561-2 PG 15 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA 662RP UT WOS:000282829500008 ER PT J AU Fitzgibbon, BM Enticott, PG Rich, AN Giummarra, MJ Georgiou-Karistianis, N Tsao, JW Weeks, SR Bradshaw, JL AF Fitzgibbon, Bernadette M. Enticott, Peter G. Rich, Anina N. Giummarra, Melita J. Georgiou-Karistianis, Nellie Tsao, Jack W. Weeks, Sharon R. Bradshaw, John L. TI High incidence of 'synaesthesia for pain' in amputees SO NEUROPSYCHOLOGIA LA English DT Article DE Mirror systems; Phantom pain ID RESIDUAL LIMB PAIN; TOUCH SYNAESTHESIA; PHANTOM PAIN; EMPATHY; SENSATIONS; AMPUTATION; SYSTEM; FEEL AB Synaesthesia for pain is a phenomenon where a person experiences pain when observing or imagining another in pain Anecdotal reports of this type of experience have most commonly occurred in individuals who have lost a limb Distinct from phantom pain synaesthesia for pain is triggered specifically in response to pain in another Here we provide the first preliminary investigation into synaesthesia for pain in amputees to determine the incidence and characteristics of this intriguing phenomenon Self-referring amputees (n=74) answered questions on synaesthesia for pain within a broader survey of phantom pain Of the participants 162% reported that observing or imagining pain in another person triggers their phantom pain Further understanding of synaesthesia for pain may provide a greater insight to abnormal empathic function in clinical populations as well as therapeutic intervention for at risk groups (C) 2010 Elsevier Ltd All rights reserved C1 [Fitzgibbon, Bernadette M.; Giummarra, Melita J.; Georgiou-Karistianis, Nellie; Bradshaw, John L.] Monash Univ, Sch Psychol & Psychiat, Expt Neuropsychol Res Unit, Clayton, Vic 3800, Australia. [Fitzgibbon, Bernadette M.; Enticott, Peter G.] Monash Univ, Sch Psychol & Psychiat, Monash Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia. [Fitzgibbon, Bernadette M.; Enticott, Peter G.] Alfred Hosp, Melbourne, Vic 3004, Australia. [Rich, Anina N.] Macquarie Univ, Macquarie Ctr Cognit Sci, N Ryde, NSW 2109, Australia. [Tsao, Jack W.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Weeks, Sharon R.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Fitzgibbon, BM (reprint author), Alfred Hosp, Monash Alfred Psychiat Res Ctr, 55 Commercial Rd,POB 315, Prahran, Vic 3181, Australia. RI Giummarra, Melita/H-8387-2012; Georgiou-Karistianis, Nellie/H-9727-2014; OI Giummarra, Melita/0000-0001-7839-6058; Georgiou-Karistianis, Nellie/0000-0003-0718-6760; Weeks, Sharon/0000-0002-9952-9136; Enticott, Peter/0000-0002-6638-951X; Fitzgibbon, Bernadette/0000-0002-5339-5304 FU Australian Research Council [DP0984494]; Menzies Foundation; NHMRC; Department of the US Army [W81XWH-06-2-0073]; US Army Medical Research [21702-5014] FX We thank the people who kindly completed our survey ANR is supported by an Australian Research Council postdoctoral fellowship (DP0984494) and the Menzies Foundation PGE is supported by an NHMRC Training Fellowship SW was sponsored by the Military Amputee Research Program through the Department of the US Army under Award Number W81XWH-06-2-0073 to the Henry M Jackson Foundation for the Advancement of Military Medicine Inc The US Army Medical Research Acquisition Activity 820 Chandler Street Fort Detrick MD 21702-5014 is the awarding and administering acquisition office The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the United States Department of the Navy the Department of the Army or the Department of Defense NR 24 TC 24 Z9 24 U1 2 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0028-3932 J9 NEUROPSYCHOLOGIA JI Neuropsychologia PD OCT PY 2010 VL 48 IS 12 BP 3675 EP 3678 DI 10.1016/j.neuropsychologia.2010.07.029 PG 4 WC Behavioral Sciences; Neurosciences; Psychology, Experimental SC Behavioral Sciences; Neurosciences & Neurology; Psychology GA 677UM UT WOS:000284017300037 PM 20670636 ER PT J AU Gallagher, SP Wright, DW Collins, BW Adams, PB AF Gallagher, Sean P. Wright, David W. Collins, Barry W. Adams, Peter B. TI A Regional Approach for Monitoring Salmonid Status and Trends: Results from a Pilot Study in Coastal Mendocino County, California SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID CHINOOK SALMON; REDD COUNTS; DESIGN AB In coastal California, many evolutionarily significant units (ESUs) of Chinook salmon Oncorhynchus tshawytscha, coho salmon O. kisutch, and steelhead O. mykiss are listed under the federal Endangered Species Act (ESA). Monitoring species status at the ESU or ESU subdivision scale requires specialized sampling. The purposes of this study were (1) to evaluate abundance estimated from a generalized random tessellation stratified (GRTS) design and compare the results with those from a more intensive stratified random monitoring program and (2) to evaluate the statistical power of the design to detect population trends. This 3-year pilot study considered five Mendocino County streams as an example region of coastal California to evaluate a two-stage sampling approach for monitoring regional escapement. Under this scheme, regional redd surveys (stage 1) were conducted in stream reaches in a GRTS sampling design. Ten percent of anadromous habitat was sampled in year 1 and 10-35% in years 2 and 3. Spawner : redd ratios were derived from smaller-scale census watersheds (stage 2) where "true" escapement was estimated using capture-recapture methods. Regional escapement was then estimated from expanded redd counts, calibrated by spawner : redd ratios. As an alternative, more intensive method for estimating escapement, three survey streams were also sampled in a stratified random design. The results, added to counts from the census basins, produced more rigorous "sum-of-streams'' estimates for comparison with the GRTS sampling. Redd counts and the resulting escapement estimates were reliable for regional monitoring. The GRTS and sum-of-streams estimates overlapped, and the variation in the 95% confidence intervals did not change after 15%. Our results suggest that a sample size of 15% or 41 or more reaches (whichever results in fewer survey reaches) should have adequate precision and statistical power to detect regional trends in salmon populations. We recommend that this monitoring approach be applied at regional spatial scales consistent with ESA recovery planning efforts. C1 [Wright, David W.] Campbell Timberlands Management LLC, Ft Bragg, CA 95437 USA. [Collins, Barry W.] Calif Dept Fish & Game, Fortuna, CA 95540 USA. [Adams, Peter B.] Natl Ocean & Atmospher Adm Fisheries, SW Fisheries Sci Ctr, Santa Cruz, CA 95060 USA. [Gallagher, Sean P.] Calif Dept Fish & Game, Ft Bragg, CA 95437 USA. RP Gallagher, SP (reprint author), Calif Dept Fish & Game, 306 E Redwood Ave, Ft Bragg, CA 95437 USA. EM sgallagh@dfg.ca.gov FU California Department of Fish and Game's (CDFG) [P0410527, P0510544, P0610540] FX This work was funded by the California Department of Fish and Game's (CDFG) Fisheries Restoration Grant Program (grants P0410527, P0510544, and P0610540). Eric Bjorkstedt, Glen Szerlong, Tommy Williams (NOAA-Fisheries, Santa Cruz), Scott Harris, George Neillands, Morgan Knechtle, Seth Ricker (CDFG), Danna McCain (Institute for River Ecosystems), Trent McDonald (West, Inc.), and Steven Levesque (Campbell Timberlands Management) helped to develop this study. Thanks to Walt Duffy, Mark Gard, Sean Hayes, and three anonyms reviewers for critical review that greatly improved this manuscript. Too many individuals to mention by name from the following entities helped with this study: CDFG, Campbell Timberlands Management, NOAA-Fisheries Santa Cruz, and the Pacific States Marine Fisheries Commission. A few we are compelled to mention are Stan Allen for administrative support; Megan Balter, Shaun Thompson, Wendy Holloway, Chris Hannon, and Katie Webster for many long hours in the field; and Josh Pope for his database savvy. Thanks to Matt Goldsworthy and the Mendocino Redwood Company for granting access to streams on their property. Colin Gallagher of the Department of Mathematical Sciences, Clemson University, Clemson, South Carolina, provided valuable tips and help with some of the statistical analysis. NR 29 TC 1 Z9 1 U1 1 U2 8 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD OCT PY 2010 VL 30 IS 5 BP 1075 EP 1085 DI 10.1577/M09-203.1 PG 11 WC Fisheries SC Fisheries GA 673MB UT WOS:000283666100001 ER PT J AU Gallagher, SP Adams, PB Wright, DW Collins, BW AF Gallagher, Sean P. Adams, Peter B. Wright, David W. Collins, Barry W. TI Performance of Spawner Survey Techniques at Low Abundance Levels SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID SPRING CHINOOK SALMON; COHO SALMON; REDD COUNTS; BULL TROUT; ESCAPEMENT; CALIFORNIA; STREAMS; RIVER; TIME AB Population monitoring is essential to know whether coastal California's Endangered Species Act-listed Chinook salmon Oncorhynchus tshawytscha, coho salmon O. kisutch, and steelhead O. mykiss stocks are progressing toward recovery. In coastal California, salmonids are at the southern edge of their range, and this one of many reasons they are not abundant. This provides unique challenges for monitoring, as different survey methods will result in estimates with different levels of accuracy and precision, which are important for evaluating population trends. For this study we intensively monitored three Mendocino County watersheds to evaluate the reliability of two-stage data for monitoring regional escapement. Under this scheme, regional spawning surveys (stage 1) were calibrated with data from intensively monitored watersheds (stage 2), where escapement was estimated using capture-recapture methods, redd counts, and fish counts. The objective of the study was to evaluate the quality of the stage 2 data for calibrating regional surveys. We evaluated the precision of live-fish capture-recapture estimates and compared these estimates with estimates derived from spawning survey data using carcass capture-recapture, area under the curve (AUC), and redd counts. Live-fish capture-recapture produced escapement estimates with narrower 95% confidence bounds where permanent structures were used to capture fish. Redd counts converted to fish numbers using spawner : redd ratios were chosen for the regional salmonid monitoring method because they were reliable, economical, and less intrusive. Converted redd counts were statistically and operationally similar to live-fish capture-recapture estimates but required fewer resources. The AUC estimates were less reliable than converted redd counts and live-fish capture-recapture methods due to the sensitivity of the estimates of residence time and observer efficiency. Finally, we found that carcass capture-recapture methods were operationally unsuccessful in coastal California streams. On the basis of our results, we recommend that annual spawner : redd ratios from intensively monitored watersheds be used to calibrate redd counts for regional status and trend monitoring of California's coastal salmonids. C1 [Gallagher, Sean P.] Calif Dept Fish & Game, Ft Bragg, CA 95437 USA. [Adams, Peter B.] Natl Ocean & Atmospher Adm Fisheries, SW Fisheries Sci Ctr, Santa Cruz, CA 95060 USA. [Wright, David W.] Campbell Timberlands Management LLC, Ft Bragg, CA 95437 USA. [Collins, Barry W.] Calif Dept Fish & Game, Fortuna, CA 95540 USA. RP Gallagher, SP (reprint author), Calif Dept Fish & Game, 306 E Redwood Ave, Ft Bragg, CA 95437 USA. EM sgallagh@dfg.ca.gov FU California Department of Fish and Game's (CDFG) [P0410527, P0510544, P0610540] FX This work was funded by the California Department of Fish and Game's (CDFG) Fisheries Restoration Grant Program (grants P0410527, P0510544, and P0610540). Eric Bjorkstedt, Glen Szerlong, and Tommy Williams (NOAA-Fisheries Santa Cruz); George Neillands, Scott Harris, Morgan Knechtle, and Seth Ricker (CDFG); Danna McCain (Humboldt State University); Trent McDonald (West, Inc.); and Steven Levesque (Campbell Timberlands Management) helped to develop this study. Thanks to Mark Gard, Sean Hayes, Walt Duffy, and three anonymous reviewers for critical review that greatly improved earlier versions of this manuscript. Too many individuals to mention by name from the following entities helped with this study: CDFG, Campbell Timberlands Management, NOAA-Fisheries Santa Cruz, and the Pacific States Marine Fisheries Commission. Be assured we value your help. A few we are compelled to mention by name include Stan Allen for administrative support; Megan Balter, Shaun Thompson, Wendy Holloway, Chris Hannon, and Katie Webster for many long hours in the field; and Josh Pope for his database savvy. Colin Gallagher, Department of Mathematical Sciences, Clemson University, South Carolina, provided valuable tips and help with some of the statistical analysis. NR 31 TC 3 Z9 3 U1 1 U2 11 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD OCT PY 2010 VL 30 IS 5 BP 1086 EP 1097 DI 10.1577/M09-204.1 PG 12 WC Fisheries SC Fisheries GA 673MB UT WOS:000283666100002 ER PT J AU Irish, JL Frey, AE Rosati, JD Olivera, F Dunkin, LM Kaihatu, JM Ferreira, CM Edge, BL AF Irish, Jennifer L. Frey, Ashley E. Rosati, Julie D. Olivera, Francisco Dunkin, Lauren M. Kaihatu, James M. Ferreira, Celso M. Edge, Billy L. TI Potential implications of global warming and barrier island degradation on future hurricane inundation, property damages, and population impacted SO OCEAN & COASTAL MANAGEMENT LA English DT Article ID SEA-LEVEL RISE; CLIMATE-CHANGE; TROPICAL CYCLONES; NEW-JERSEY; NEW-YORK; STORM; COASTAL; INTENSITY; BANGLADESH; SURGE AB Hurricane flooding is a leading natural threat to coastal communities Recent evidence of sea level rise coupled with potential future global warming indicate that sea level rise will accelerate and hurricanes may intensify over the coming decades In regions fronted by barrier islands the protective capacity of these islands may diminish as they are degraded by rising sea level Here we present a hydrodynamic and geospatial analysis of the relative role of barrier island degradation on potential future hurricane flooding For the City of Corpus Christi Texas USA hurricane flooding is projected to rise between 20% and 70% by the 2030s resulting in an increase in property damages and impacted population These findings indicate that adaptive management strategies should be developed and adopted for mitigating loss of natural barrier islands when these Islands act as protective features for populated bayside communities Finally this study illustrates a method for applying models to forecast future storm protection benefits of barrier island restoration projects (C) 2010 Elsevier Ltd All rights reserved C1 [Irish, Jennifer L.; Frey, Ashley E.; Olivera, Francisco; Dunkin, Lauren M.; Kaihatu, James M.; Ferreira, Celso M.; Edge, Billy L.] Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA. [Rosati, Julie D.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Mobile, AL 36628 USA. RP Irish, JL (reprint author), Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA. RI Ferreira, Celso/I-3647-2015; Kaihatu, James/H-7561-2016; OI Ferreira, Celso/0000-0001-9032-9624; Kaihatu, James/0000-0002-9277-6409; Edge, Billy/0000-0001-9291-3920; Irish, Jennifer/0000-0002-2429-5953 FU National Commission on Energy Policy [C07-00604]; US Army Engineer Research and Development Center; Texas General Land Office via National Oceanic and Atmospheric Administration [C08-00216] FX This research was funded by the National Commission on Energy Policy (Grant No C07-00604) the Texas General Land Office via a Grant/Cooperative Agreement from the National Oceanic and Atmospheric Administration (Grant No C08-00216) and the US Army Engineer Research and Development Center The views expressed herein are those of the authors and do not necessarily reflect views of NOAA or any of its subagencies The use of trade names does not constitute an endorsement in the use of these products by the U S Government NR 67 TC 12 Z9 12 U1 3 U2 40 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0964-5691 J9 OCEAN COAST MANAGE JI Ocean Coastal Manage. PD OCT PY 2010 VL 53 IS 10 BP 645 EP 657 DI 10.1016/j.ocecoaman.2010.08.001 PG 13 WC Oceanography; Water Resources SC Oceanography; Water Resources GA 682XZ UT WOS:000284437600005 ER PT J AU Leavitt, K Mitchell, TR Peterson, J AF Leavitt, Keith Mitchell, Terence R. Peterson, Jeff TI Theory Pruning: Strategies to Reduce Our Dense Theoretical Landscape SO ORGANIZATIONAL RESEARCH METHODS LA English DT Article DE philosophy of science; quantitative research; research design ID PSYCHOLOGICAL-RESEARCH; STRONG INFERENCE; CONFIDENCE-INTERVALS; MANAGEMENT RESEARCH; STATISTICAL POWER; NULL-HYPOTHESIS; METAANALYSIS; REPLICATION; CONSTRUCTS; PROGRESS AB The current article presents a systematic approach to theory pruning (defined here as hypothesis specification and study design intended to bound and reduce theory). First, we argue that research that limits theory is underrepresented in the organizational sciences, erring overwhelmingly on the side of confirmatory null hypothesis testing. Second, we propose criteria for determining comparability, deciding when it is appropriate to test theories or parts of theories against one another. Third, we suggest hypotheses or questions for testing competing theories. Finally, we revisit the spirit of "strong inference." We present reductionist strategies appropriate for the organizational sciences, which extend beyond traditional approaches of "critical" comparisons between whole theories. We conclude with a discussion of strong inference in organizational science and how theory pruning can help in that pursuit. C1 [Leavitt, Keith] US Mil Acad, Army Ctr Profess Mil Eth, West Point, NY 10996 USA. [Mitchell, Terence R.] Univ Washington, Foster Sch Business, Seattle, WA 98195 USA. [Peterson, Jeff] Utah Valley Univ, Woodbury Sch Business, Orem, UT USA. RP Leavitt, K (reprint author), US Mil Acad, Army Ctr Profess Mil Eth, West Point, NY 10996 USA. EM keith.leavitt@usma.edu RI Leavitt, Keith/D-6686-2012; Peterson, Jeff/D-7478-2012 OI Leavitt, Keith/0000-0003-3729-3997; Peterson, Jeff/0000-0001-6505-0779 NR 82 TC 50 Z9 50 U1 4 U2 27 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1094-4281 J9 ORGAN RES METHODS JI Organ. Res. Methods PD OCT PY 2010 VL 13 IS 4 BP 644 EP 667 DI 10.1177/1094428109345156 PG 24 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 648HC UT WOS:000281680800003 ER PT J AU Ali, A Furusato, B Ts'o, POP Lum, ZP Elsamanoudi, S Mohamed, A Srivastava, S Moul, JW Brassell, SA Sesterhenn, IA McLeod, DG AF Ali, Amina Furusato, Bungo Ts'o, Paul O. P. Lum, Zhao-Ping Elsamanoudi, Sally Mohamed, Ahmed Srivastava, Shiv Moul, Judd W. Brassell, Stephen A. Sesterhenn, Isabell A. McLeod, David G. TI Assessment of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors SO PATHOLOGY INTERNATIONAL LA English DT Article DE circulating tumor cells; CTCs; insignificant; prostate cancer; small-volume ID RADICAL PROSTATECTOMY; PREOPERATIVE PREDICTION; SYSTEMATIC BIOPSIES; SPECIMENS; ANTIGEN; STAGE; MEN; IDENTIFICATION; BLOOD AB The objective of this study was to assess the incidence of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors (less than 0.5 cc) after radical prostatectomy (RP). Blood samples were collected from 64 RP patients to assess the incidence of CTCs following RP. The specimens were processed by whole-mount section. Clinicopathological data (e.g. patient age, race, specimen weight, tumor volume, grade, stage and surgical margin status) and follow-up PSA data were compared to CTC status. Of the 64 RP patients, nine had 'low-volume prostate cancer'. Seven of these patients had detectable levels of CTCs. In two of the seven patients with detectable CTCs, PSA elevation was also observed. Isolation and detection of circulating epithelial cells is possible in low-volume prostate cancer patients. In the setting of low-volume prostate cancer, CTCs may be associated with the presence of detectable PSA levels. However, the detection of CTCs did not predict PSA failure. C1 [McLeod, David G.] Walter Reed Army Med Ctr, Multi Disciplinary Prosate Canc Clin, Ctr Prostate Dis Res, Washington, DC 20307 USA. [Ali, Amina; Furusato, Bungo; Elsamanoudi, Sally; Mohamed, Ahmed; Srivastava, Shiv; Brassell, Stephen A.; McLeod, David G.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Furusato, Bungo; Sesterhenn, Isabell A.] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. [Ts'o, Paul O. P.; Lum, Zhao-Ping] LLC, CCC Diagnost, Baltimore, MD USA. [Moul, Judd W.] Duke Univ, Med Ctr, Div Urol Surg, Durham, NC USA. [Moul, Judd W.] Duke Univ, Med Ctr, Duke Prostate Ctr, Durham, NC USA. [Moul, Judd W.] Duke Univ, Med Ctr, Dept Surg, Durham, NC USA. RP McLeod, DG (reprint author), Walter Reed Army Med Ctr, Multi Disciplinary Prosate Canc Clin, Ctr Prostate Dis Res, Ward 56,6900 Georgia Ave NW, Washington, DC 20307 USA. EM dgmcleod@verizon.net OI Furusato, Bungo/0000-0003-4614-9882 NR 23 TC 4 Z9 5 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1320-5463 J9 PATHOL INT JI Pathol. Int. PD OCT PY 2010 VL 60 IS 10 BP 667 EP 672 DI 10.1111/j.1440-1827.2010.02584.x PG 6 WC Pathology SC Pathology GA 651BG UT WOS:000281899000003 PM 20846264 ER PT J AU Cassenti, DN Kelley, TD Ghirardelli, TG AF Cassenti, Daniel N. Kelley, Troy D. Ghirardelli, Thomas G. TI UNDERESTIMATING NUMEROSITY OF ITEMS IN VISUAL SEARCH TASKS SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID PERCEIVED NUMEROSITY; INTEGRATION; STRATEGIES; JUDGMENTS AB Previous research on numerosity judgments addressed attended items while the present research addresses underestimation for unattended items in visual search tasks One potential cause of underestimation for unattended items is that estimates of quantity may depend on viewing a large portion of the display within foveal vision Another theory follows from the occupancy model estimating quantity of Items in greater proximity to one another increases the likelihood of an underestimation error Three experimental manipulations addressed aspects of underestimation for unattended items the size of the distracters the distance of the target from fixation and whether Items were clustered together Results suggested that the underestimation effect for unattended items was best explained within a Gestalt grouping framework. C1 [Cassenti, Daniel N.; Kelley, Troy D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Ghirardelli, Thomas G.] Goucher Coll, Towson, MD USA. RP Cassenti, DN (reprint author), USA, Res Lab, RDRL HRS Bldg 459, Aberdeen Proving Ground, MD 21005 USA. NR 29 TC 0 Z9 0 U1 0 U2 9 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD OCT PY 2010 VL 111 IS 2 BP 379 EP 398 DI 10.2466/04.22.24.27.PMS.111.5.379-398 PG 20 WC Psychology, Experimental SC Psychology GA 681EF UT WOS:000284293500007 PM 21162441 ER PT J AU Williams, SG Alinejad, NA Williams, JA Cruess, DF AF Williams, Scott G. Alinejad, Nima A. Williams, Jeannie A. Cruess, David F. TI Statistically Significant Increase in Weight Caused by Low-Dose Quetiapine SO PHARMACOTHERAPY LA English DT Article DE quetiapine; weight; antipsychotics; adverse effects ID ATYPICAL ANTIPSYCHOTIC-DRUGS; SCHIZOPHRENIA; OLANZAPINE; TOLERABILITY; MEDICATIONS; RISPERIDONE; CLOZAPINE; PATTERNS; GAIN AB Study Objective. To determine if preliminary data suggest that low-dose quetiapine is associated with weight gain. Design. Retrospective medical record review. Setting. Two military hospitals serving active-duty soldiers, family members of service members, and military retirees. Patients. Five hundred thirty-four adult military health care beneficiaries who received quetiapine at a total daily dose of 100 mg or less for a minimum of 1 month between January 1, 2005, and June 30, 2008. Measurements and Main Results. The mean weight at baseline was 175.68 lbs. The mean +/- standard error weight gain compared with baseline was 0.49 +/- 0.51 lbs (p=0.335) at 1 month, increasing in a generally linear fashion to 5.56 +/- 1.25 lbs (p<0.001) at 6 months, and 10.58 +/- 2.20 lbs (p<0.001) at 12 months. Conclusion. Low-dose quetiapine caused a statistically significant weight gain in our study population. This finding highlights the need for greater recognition of the potential for quetiapine to cause undesirable effects, and demonstrates the importance of close monitoring of physiologic parameters during treatment. C1 [Williams, Scott G.; Williams, Jeannie A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Alinejad, Nima A.] Malcolm Grow Med Ctr, Andrews AFB, MD USA. [Cruess, David F.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Williams, SG (reprint author), Walter Reed Army Med Ctr, Ward 74,6900 Georgia Ave NW, Washington, DC 20307 USA. EM scott.g.williams@us.army.mil NR 23 TC 12 Z9 14 U1 0 U2 4 PU PHARMACOTHERAPY PUBLICATIONS INC PI BOSTON PA NEW ENGLAND MEDICAL CENTER, 806, 750 WASHINGTON ST, BOSTON, MA 02111 USA SN 0277-0008 J9 PHARMACOTHERAPY JI Pharmacotherapy PD OCT PY 2010 VL 30 IS 10 BP 1011 EP 1015 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 662SI UT WOS:000282831700006 PM 20874038 ER PT J AU Childs, JD Teyhen, DS Casey, PR McCoy-Singh, KA Feldtmann, AW Wright, AC Dugan, JL Wu, SS George, SZ AF Childs, John D. Teyhen, Deydre S. Casey, Patrick R. McCoy-Singh, Kimberly A. Feldtmann, Angela W. Wright, Alison C. Dugan, Jessica L. Wu, Samuel S. George, Steven Z. TI Effects of Traditional Sit-up Training Versus Core Stabilization Exercises on Short-Term Musculoskeletal Injuries in US Army Soldiers: A Cluster Randomized Trial SO PHYSICAL THERAPY LA English DT Article ID LOW-BACK-PAIN; CONSORT STATEMENT; PREVENTION; SURVEILLANCE; TRAINEES; QUALITY AB Background. The US Army has traditionally utilized bent-knee sit-ups as part of physical training and testing. It is unknown whether the short-term effects of a core stabilization exercise program without sit-up training may result in decreased musculoskeletal injury incidence and work restriction compared with traditional training. Objective. The objective of this study was to explore the short-term effects of a core stabilization exercise program (CSEP) without sit-up training and a traditional exercise program (TEP) on musculoskeletal injury incidence and work restriction. Design. The study was designed as a cluster randomized trial. Setting. The setting was a 16-week training program at Fort Sam Houston (San Antonio, Texas). Participants. The study participants were soldiers with a mean age of 22.9 years (SD = 4,7, range = 18-35) for whom complete injury data were available for analysis (n = 1,141). Intervention. Twenty companies of soldiers were cluster randomized to complete the CSEP (10 companies of 542 soldiers) or the TEP (10 companies of 599 soldiers). The CSEP included exercises targeting the transversus abdominus and multifidus musculature. The TEP comprised exercises targeting the rectus abdominus, oblique abdominal, and hip flexor musculature. Measurements. Research staff recorded all injuries resulting in the inability to complete full duty responsibilities. Differences in the percentages of musculoskeletal injuries were examined with chi-square analysis; independent sample t tests were used to examine differences in the numbers of days of work restriction. Results. Of the 1,141 soldiers for whom complete injury data were available for analysis, 511 (44.8%) experienced musculoskeletal injuries during training that resulted in work restrictions. There were no differences in the percentages of soldiers with musculoskeletal injuries. There also were no differences in the numbers of days of work restriction for musculoskeletal injuries overall or specific to the upper extremity. However, soldiers who completed the TEP and experienced a low back injury had more days of work restriction: 8.3 days (SD = 14.5) for the TEP group and 4.2 days (SD = 8.0) for the CSEP group. Limitations. A limitation of this study was the inconsistent reporting of injuries during training. However, the rates of reporting were similar between the groups. Conclusions. The incidence of musculoskeletal injuries was similar between the groups. There was marginal evidence that the CSEP resulted in fewer days of work restriction for low back injuries. C1 [Childs, John D.; Teyhen, Deydre S.; Casey, Patrick R.; McCoy-Singh, Kimberly A.; Feldtmann, Angela W.; Wright, Alison C.; Dugan, Jessica L.] Baylor Univ, USA, Doctoral Program Phys Therapy MCCS HMT, Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Wu, Samuel S.] Univ Florida, Dept Epidemiol & Hlth Policy Res, Gainesville, FL USA. [George, Steven Z.] Univ Florida, Dept Phys Therapy, Ctr Pain Res & Behav Treatment, Gainesville, FL USA. RP Childs, JD (reprint author), Baylor Univ, USA, Doctoral Program Phys Therapy MCCS HMT, Army Med Dept Ctr & Sch, Scott Rd,Room 2307, Ft Sam Houston, TX 78234 USA. EM childsjd@gmail.com FU Congressionally Directed Peer-Reviewed Medical Research Program [W81XWH-06-1-0564] FX This study was funded by the Congressionally Directed Peer-Reviewed Medical Research Program (W81XWH-06-1-0564). NR 31 TC 14 Z9 15 U1 0 U2 13 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD OCT PY 2010 VL 90 IS 10 BP 1404 EP 1412 DI 10.2522/ptj.20090389 PG 9 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 656TP UT WOS:000282360000004 PM 20651013 ER PT J AU Burns, TC Owens, BD AF Burns, Travis C. Owens, Brett D. TI Management of Shoulder Instability in In-Season Athletes SO PHYSICIAN AND SPORTSMEDICINE LA English DT Article DE shoulder; instability; dislocation; athlete; sport; brace; surgery ID TRAUMATIC ANTERIOR DISLOCATION; ARTHROSCOPIC BANKART REPAIR; RANDOMIZED CLINICAL-TRIAL; NONOPERATIVE TREATMENT; EXTERNAL ROTATION; UNITED-STATES; BONE DEFECTS; FOLLOW-UP; JOINT; STABILIZATION AB Although shoulder instability is common in young athletes, there are limited prospective data to guide treatment for competitive athletes who sustain a dislocation mid-season. The management of athletes during their competitive season requires an understanding of the natural history of shoulder instability, the specific needs of the injured athlete (eg, specific sport, player position), and the duration of treatment. Rehabilitation can enable an athlete with a shoulder dislocation to return to play within 3 weeks of injury. Bracing is an option, but it can result in restricted glenohumeral motion and thereby possibly affect performance. Surgical stabilization should be considered for the athlete with recurrent instability or inability to perform; however, this frequently results in the termination of the player's season. In this article, we review the available literature to help guide physicians treating athletes with shoulder instability. C1 [Burns, Travis C.; Owens, Brett D.] Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 48 TC 9 Z9 10 U1 0 U2 13 PU JTE MULTIMEDIA PI BERWYN PA 1235 WESTLAKES DR, STE 220, BERWYN, PA 19312 USA SN 0091-3847 J9 PHYSICIAN SPORTSMED JI Physician Sportsmed. PD OCT PY 2010 VL 38 IS 3 BP 55 EP 60 DI 10.3810/psm.2010.10.1808 PG 6 WC Primary Health Care; Orthopedics; Sport Sciences SC General & Internal Medicine; Orthopedics; Sport Sciences GA 764LI UT WOS:000290630600015 PM 20959696 ER PT J AU Limb, RF Engle, DM Bidwell, TG Althoff, DP Anderson, AB Gipson, PS Howard, HR AF Limb, Ryan F. Engle, David M. Bidwell, Terrence G. Althoff, Donald P. Anderson, Alan B. Gipson, Philip S. Howard, Heidi R. TI Restoring biopedturbation in grasslands with anthropogenic focal disturbance SO PLANT ECOLOGY LA English DT Article DE Grazing, hay harvest; Resilience, resistance; Soil disturbance; Successional trajectory; Tracked vehicles ID SOIL-WATER CONTENT; TALLGRASS PRAIRIE; ECOSYSTEM PROCESSES; PLANT-COMMUNITIES; NORTH-AMERICA; SPECIES COMPOSITION; BUFFALO WALLOWS; POCKET GOPHERS; STABLE STATES; VEGETATION AB Grassland ecosystems evolved with natural disturbance events on multiple spatial scales in which focal, fine-scale soil disturbance by animals often was imbedded within large-scale grazing disturbance. The resulting plant communities adapted to both broad-scale and fine-scale disturbance that resulted in species-rich plant communities. These natural disturbance regimes have been largely replaced by anthropogenic disturbance. While we generally understand grassland response to modern grazing practices, we know much less about plant community response to soil disturbance imbedded within non-focal grazing. Therefore, we used a tracked vehicle to focally disturb soil in a North American mesic mixed prairie that was either undisturbed prairie or prairie with a recent history of disturbance from either grazing or haying. Successional trajectory and recovery time following focal soil disturbance was similar between grazed and hayed plant communities. Species composition did not differ (P < 0.05) between grazed or hayed prairie and the respective undisturbed prairie. Plant species richness and bare ground increased (P < 0.05) following focal soil disturbance in both grazed and hayed communities, but focal soil disturbance combined with either grazing or haying did not change either plant species richness or bare ground more than (P > 0.05) focal soil disturbance alone. Also, the effect of focal soil disturbance was shortlived with recovery in two growing seasons. Our results suggest that anthropogenic focal soil disturbance is a reasonable mechanism to restore soil disturbance to the grassland ecosystem. C1 [Limb, Ryan F.; Engle, David M.; Bidwell, Terrence G.] Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74075 USA. [Althoff, Donald P.] Univ Rio Grande, Sch Sci, Rio Grande, OH USA. [Anderson, Alan B.; Howard, Heidi R.] USA, ERDC, Construct Engn Res Lab, Champaign, IL USA. [Gipson, Philip S.] Texas Tech Univ, Dept Nat Resources Management, Lubbock, TX 79409 USA. RP Limb, RF (reprint author), Oklahoma State Univ, Dept Nat Resource Ecol & Management, 008C Agr Hall, Stillwater, OK 74075 USA. EM ryan.limb@okstate.edu FU Oklahoma Agricultural Experiment Station; United States Army Engineer Research and Development Center-Construction Engineering Research Laboratory [W9132T-07-P-0095] FX This research was funded by the Oklahoma Agricultural Experiment Station and the United States Army Engineer Research and Development Center-Construction Engineering Research Laboratory grant number W9132T-07-P-0095. We thank US Air National Guard, Galen Wiens and numerous technicians for assistance with various aspects of the study. NR 89 TC 7 Z9 7 U1 3 U2 13 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1385-0237 J9 PLANT ECOL JI Plant Ecol. PD OCT PY 2010 VL 210 IS 2 BP 331 EP 342 DI 10.1007/s11258-010-9760-7 PG 12 WC Plant Sciences; Ecology; Forestry SC Plant Sciences; Environmental Sciences & Ecology; Forestry GA 642ZE UT WOS:000281259700011 ER PT J AU Beitzel, BF Bakken, RR Smith, JM Schmaljohn, CS AF Beitzel, Brett F. Bakken, Russell R. Smith, Jeffrey M. Schmaljohn, Connie S. TI High-Resolution Functional Mapping of the Venezuelan Equine Encephalitis Virus Genome by Insertional Mutagenesis and Massively Parallel Sequencing SO PLOS PATHOGENS LA English DT Article ID TEMPERATURE-SENSITIVE MUTANTS; STRAND RNA-SYNTHESIS; NONSTRUCTURAL PROTEIN NSP2; SINDBIS-VIRUS; MINUS-STRAND; IN-VITRO; METHYLTRANSFERASE ACTIVITY; REPLICATION COMPLEXES; MACRO DOMAINS; POLYPROTEINS AB We have developed a high-resolution genomic mapping technique that combines transposon-mediated insertional mutagenesis with either capillary electrophoresis or massively parallel sequencing to identify functionally important regions of the Venezuelan equine encephalitis virus (VEEV) genome. We initially used a capillary electrophoresis method to gain insight into the role of the VEEV nonstructural protein 3 (nsP3) in viral replication. We identified several regions in nsP3 that are intolerant to small (15 bp) insertions, and thus are presumably functionally important. We also identified nine separate regions in nsP3 that will tolerate small insertions at low temperatures (30 degrees C), but not at higher temperatures (37 degrees C, and 40 degrees C). Because we found this method to be extremely effective at identifying temperature sensitive (ts) mutations, but limited by capillary electrophoresis capacity, we replaced the capillary electrophoresis with massively parallel sequencing and used the improved method to generate a functional map of the entire VEEV genome. We identified several hundred potential ts mutations throughout the genome and we validated several of the mutations in nsP2, nsP3, E3, E2, E1 and capsid using single-cycle growth curve experiments with virus generated through reverse genetics. We further demonstrated that two of the nsP3 ts mutants were attenuated for virulence in mice but could elicit protective immunity against challenge with wild-type VEEV. The recombinant ts mutants will be valuable tools for further studies of VEEV replication and virulence. Moreover, the method that we developed is applicable for generating such tools for any virus with a robust reverse genetics system. C1 [Beitzel, Brett F.; Bakken, Russell R.; Smith, Jeffrey M.; Schmaljohn, Connie S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Beitzel, BF (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM connie.schmaljohn@us.army.mil FU USAMRIID FX This work was funded by a USAMRIID Intra-laboratory Innovative Research award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 52 TC 11 Z9 11 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD OCT PY 2010 VL 6 IS 10 AR e1001146 DI 10.1371/journal.ppat.1001146 PG 13 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 673IG UT WOS:000283652200022 PM 20976195 ER PT J AU Rowland, B Jolley, D Bennett, B Johnson, B Moffett, G Adair, L Hanning-Lee, M Bottelberghe, G Mamo, T Kaufman, J AF Rowland, Brad Jolley, Darren Bennett, Brian Johnson, Brian Moffett, Gary Adair, Laurence Hanning-Lee, Mark Bottelberghe, Gregory Mamo, Tsenu Kaufman, Jon TI Test method and simple analysis model for off-gassing studies of military-relevant surfaces contaminated with chemical warfare agent simulants SO POLYMER TESTING LA English DT Article DE Off-gassing; Simulant; Agent; Chromatography; Surface AB This study was conducted to develop methods for testing off-gassing from select military-relevant surfaces and to establish a model for predicting off-gassing from a broad range of such surfaces. Vapor contaminated surfaces were investigated by exposing representative field materials to chemical warfare agent (CWA) simulants, and then monitoring the off-gassing concentration as a function of time. Concrete, plastic, wood, steel and latex paint surfaces were contaminated with triethyl phosphate, 4-chlorobutyl acetate, 3-hepten-2-one, trimethyl phosphate, and 2-isobutyl-3-methoxypyrazine. The testing process and simple analysis model provide test and analysis methods that will be used to test agent off-gassing and can serve as a standard for vapor hazard testing following vapor exposure. Use of the simple model was justified, based on analyses of the measured off-gassing trends and the predicted trends of interaction between each compound and each surface. Published by Elsevier Ltd. C1 [Rowland, Brad; Jolley, Darren; Bennett, Brian; Johnson, Brian; Moffett, Gary; Adair, Laurence] USA, Dugway Proving Ground, TEDT DPW CTC, Dugway, UT 84022 USA. [Hanning-Lee, Mark; Bottelberghe, Gregory] Jacobs Dugway Team, Dugway, UT 84022 USA. [Mamo, Tsenu] Sci & Technol Corp, Dugway, UT 84022 USA. [Kaufman, Jon] Def Threat Reduct Agcy, Joint Sci & Technol Off, Patuxent River, MD 20670 USA. RP Jolley, D (reprint author), USA, Dugway Proving Ground, TEDT DPW CTC, MS 6,4531 B St, Dugway, UT 84022 USA. EM darren.jolley@us.army.mil FU Joint Science and Technology Office Defense Threat Reduction Agency [CA06TAS438] FX This work was funded by Joint Science and Technology Office Defense Threat Reduction Agency under contract number CA06TAS438. NR 13 TC 2 Z9 2 U1 2 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9418 J9 POLYM TEST JI Polym. Test PD OCT PY 2010 VL 29 IS 7 BP 777 EP 783 DI 10.1016/j.polymertesting.2010.06.006 PG 7 WC Materials Science, Characterization & Testing; Polymer Science SC Materials Science; Polymer Science GA 657YW UT WOS:000282456400003 ER PT J AU Pettit, CL Wilson, DK AF Pettit, Chris L. Wilson, D. Keith TI Full-field sensitivity analysis through dimension reduction and probabilistic surrogate models SO PROBABILISTIC ENGINEERING MECHANICS LA English DT Article DE Sensitivity analysis; Surrogate model; Bayesian ID PROPER ORTHOGONAL DECOMPOSITION; SOUND-PROPAGATION; UNCERTAINTY; TUTORIAL AB Computational mechanics models often are compromised by uncertainty in their governing parameters, especially when the operating environment is incompletely known. Computational sensitivity analysis of a spatially distributed process to its governing parameters therefore is an essential, but often costly, step in uncertainty quantification. A sensitivity analysis method is described which features probabilistic surrogate models developed through equitable sampling of the parameter space, proper orthogonal decomposition (POD) for compact representations of the process' variability from an ensemble of realizations, and cluster-weighted models of the joint probability density function of each POD coefficient and the governing parameters. Full-field sensitivities, i.e. sensitivities at every point in the computational grid, are computed by analytically differentiating the conditional expected value function of each POD coefficient and projecting the sensitivities onto the POD basis. Statistics of the full-field sensitivities are estimated by sampling the surrogate model throughout the parameter space. Major benefits of this method are: (1) the sensitivities are computed analytically and efficiently from regularized surrogate models, and (2) the conditional variances of the surrogate models may be used to estimate the statistical uncertainty in the sensitivities, which provides a basis for pursuing more data to improve the model. Synthetic examples and a physical example involving near-ground sound propagation through a refracting atmosphere are presented to illustrate the properties of the surrogate models and how full-field sensitivities and their uncertainties are computed. Published by Elsevier Ltd C1 [Pettit, Chris L.] USN Acad, Dept Aerosp Engn, Annapolis, MD 21402 USA. [Wilson, D. Keith] USA, Cold Reg Res & Engn Lab, Signature Phys Branch, Hanover, NH 03755 USA. RP Pettit, CL (reprint author), USN Acad, Dept Aerosp Engn, Annapolis, MD 21402 USA. EM pettitcl@usna.edu RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Army Engineer Research and Development Center FX This research was supported by the U.S. Army Engineer Research and Development Center's Geospatial Research and Engineering basic research program. The authors would like to thank Dr. S. Vecherin for his insightful comments on an early draft of the article. NR 38 TC 1 Z9 2 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-8920 EI 1878-4275 J9 PROBABILIST ENG MECH JI Probab. Eng. Eng. Mech. PD OCT PY 2010 VL 25 IS 4 BP 380 EP 392 DI 10.1016/j.probengmech.2010.04.005 PG 13 WC Engineering, Mechanical; Mechanics; Statistics & Probability SC Engineering; Mechanics; Mathematics GA 631XX UT WOS:000280385100004 ER PT J AU Liu, ZK Zhang, H Ganeshan, S Wang, Y Mathaudhu, SN AF Liu, Z. K. Zhang, H. Ganeshan, S. Wang, Y. Mathaudhu, S. N. TI Computational modeling of effects of alloying elements on elastic coefficients SO SCRIPTA MATERIALIA LA English DT Article DE Elastic behavior; First-principles; Electron theory modeling; CALPHAD ID 1ST-PRINCIPLES CALCULATIONS; TEMPERATURE-DEPENDENCE; VARIATIONAL APPROACH; MAGNESIUM ALLOY; CONSTANTS; MG; BEHAVIOUR; DESIGN; AL AB Models for composition and temperature dependencies of single-crystal elastic stiffness coefficients are developed and applied to the Al(12)Mg(17) and hexagonal closed-packed solution phases in the Mg-Al system based on data from first-principles calculations. In combination with models for multi-phases, the bulk, shear, and Young's moduli of Mg-Al alloys are predicted and compared with available experimental data in the literature. It is noted that both phase transition and grain boundary sliding may play important roles in the elastic coefficients as a function of temperature. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Liu, Z. K.; Zhang, H.; Ganeshan, S.; Wang, Y.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Mathaudhu, S. N.] USA, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Liu, ZK (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM dr.liu@psu.edu RI Mathaudhu, Suveen/B-4192-2009; Wang, Yi/D-1032-2013; Liu, Zi-Kui/A-8196-2009 OI Liu, Zi-Kui/0000-0003-3346-3696 FU NSF [0510180]; US Automotive Materials Partnership [DE-FC05-02OR22910]; US Army Research Laboratory [W911NF-08-2-0064] FX The authors greatly appreciate financial support from NSF Grant 0510180, the US Automotive Materials Partnership through cooperative agreement No. DE-FC05-02OR22910, and US Army Research Laboratory for the grant W911NF-08-2-0064. The authors would also like to thank Shun Li Shang, Dong Eung Kim, and Arkapol Saengdeejing at The Pennsylvania State University for stimulating discussions and careful reading of the manuscript. NR 39 TC 16 Z9 16 U1 2 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD OCT PY 2010 VL 63 IS 7 BP 686 EP 691 DI 10.1016/j.scriptamat.2010.03.049 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 639CZ UT WOS:000280949700004 ER PT J AU Bernard, JD Jordon, JB Horstemeyer, MF El Kadiri, H Baird, J Lamb, D Luo, AA AF Bernard, J. D. Jordon, J. B. Horstemeyer, M. F. El Kadiri, H. Baird, J. Lamb, David Luo, Alan A. TI Structure-property relations of cyclic damage in a wrought magnesium alloy SO SCRIPTA MATERIALIA LA English DT Article DE Structure-property; Fatigue; Magnesium alloys; Scanning electron microscopy ID CAST AM60B MAGNESIUM; IN-SITU OBSERVATIONS; FATIGUE PROPERTIES; BEHAVIOR; MECHANISMS; INCLUSIONS; PARTICLES; FRACTURE AB The fatigue properties of an extruded Mg-3Al-0Mn magnesium alloy component were evaluated experimentally. Fully reversed, strain control fatigue tests were conducted on specimens extracted from regions with a varying grain size and texture. Scanning electron microscopy was employed to establish structure property relations between microstructure and cyclic damage. Relations were drawn between microstructural features such as particle size, grain size, initial Taylor factor and the number of cycles to failure. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Bernard, J. D.; Jordon, J. B.; Horstemeyer, M. F.; El Kadiri, H.; Baird, J.] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39759 USA. [Lamb, David] USA, RDECOM TARDEC, Warren, MI 48397 USA. [Luo, Alan A.] Gen Motors Res & Dev Ctr, Chem Sci & Mat Syst Lab, Warren, MI 48090 USA. RP Jordon, JB (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, 200 Res Blvd, Starkville, MS 39759 USA. EM bjordon@cavs.msstate.edu RI El Kadiri, Haitham/F-5239-2011; Luo, Alan/J-4990-2012; Luo, Alan/G-9352-2013; OI Horstemeyer, Mark/0000-0003-4230-0063 FU Department of Energy; National Energy Technology Laboratory [DE-FC26-02OR22910]; US Army TACOM Life Cycle Command, through with Mississippi State University [W56HZV-08-C-0236]; agency of the United States Government FX The authors would like to recognize Richard Osborne, James Quinn, Xuming Su, John Allison, Robert McCune, Don Penrod, and Matthew Castanier for their encouragement of this study. This material is based upon work supported by the Department of Energy and the National Energy Technology Laboratory under Award Number No. DE-FC26-02OR22910, and the US Army TACOM Life Cycle Command under Contract No. W56HZV-08-C-0236 through a subcontract with Mississippi State University, and was performed for the Simulation Based Reliability and Safety (SimBRS) research program. This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. Such support does not constitute an endorsement by the Department of Energy of the work or the views expressed herein. UNCLASSIFIED: Dist A. Approved for public release. NR 30 TC 16 Z9 16 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD OCT PY 2010 VL 63 IS 7 BP 751 EP 756 DI 10.1016/j.scriptamat.2010.05.048 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 639CZ UT WOS:000280949700016 ER PT J AU Martini, WZ Wolf, SE Chinkes, DL Chung, KK Dubick, MA Blackbourne, L Yu, YM AF Martini, Wenjun Z. Wolf, Steven E. Chinkes, David L. Chung, Kevin K. Dubick, Michael A. Blackbourne, Lorne Yu, Yong-Ming TI ENHANCED ALBUMIN SYNTHESIS IN SEVERELY BURNED ADULTS SO SHOCK LA English DT Article DE Burn injury; stable isotopes; gas chromatography and mass spectrometry ID TRANSCAPILLARY ESCAPE RATE; PROTEIN-SYNTHESIS; HEPATIC PROTEINS; THERMAL-INJURY; AMINO-ACID; PERMEABILITY; FIBRINOGEN; METABOLISM; MORBIDITY; DISEASE AB Albumin plays an important role in maintaining physiological homeostasis. Although decreased albumin concentration has been well described as an acute-phase response following injury, it is unclear whether the decrease is due to compromised synthesis of albumin, dilution, or imbalance between synthesis and breakdown rates, particularly after injury. We investigated changes in albumin synthesis in severely burned patients using stable isotope infusion techniques. Five patients (29 +/- 3 years; 80 +/- 7 kg) with burn of 48% +/- 4% total body surface area (TBSA) were enrolled and studied in the ICU at the Burn Unit of the US Army Institute of Surgical Research. Five age-and sex-matched healthy volunteers (33 +/- 5 years; 81 +/- 6 kg) were included as controls. On the study day (13 +/- 3 days after burn), a primed constant infusion (4 h) of stable isotope d(5)-phenlylalanine and d(3)-ketoisocaproic acid was given. Hourly arterial blood samples were drawn during the infusion to determine albumin synthesis rates, using gas chromatography-mass spectrometry analysis. Burned patients had higher heart and respiration rates. Plasma total protein in burn patients (4.5 +/- 0.3 g . dL(-1)) was lower compared with controls (6.8 +/- 0.2 g . dL(-1)). Plasma albumin concentration in burn patients (1.1 +/- 0.1 g . dL(-1)) was also lower compared with controls (3.8 +/- 0.1 g . dL(-1); both P < 0.05). Albumin synthesis rate in burn patients (4.6 +/- 0.2 mg . kg(-1) . h(-1)) was enhanced compared with controls (2.2 +/- 0.2 mg . kg(-1) . h(-1); P < 0.05). Despite the decrease in albumin concentration, albumin synthesis was enhanced in severely burned patients during the flow phase. C1 [Martini, Wenjun Z.; Wolf, Steven E.; Chung, Kevin K.; Dubick, Michael A.; Blackbourne, Lorne] USA, Inst Surg Res, Houston, TX 78234 USA. [Chinkes, David L.] Univ Texas Med Branch, Galveston, TX USA. [Yu, Yong-Ming] Harvard Univ, Sch Med, Boston, MA USA. [Yu, Yong-Ming] Massachusetts Gen Hosp, Boston, MA 02114 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Houston, TX 78234 USA. EM wenjun.martini@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 FU US Army Medical Research and Materiel Command; US Army Institute of Surgical Research; Pharmacy Department at Brooke Army Medical Center FX This study was supported by the US Army Medical Research and Materiel Command.; The authors thank Annette McClinton for her regulatory assistance throughout the study. The authors appreciate the support received from the research nurses at the US Army Institute of Surgical Research and the Pharmacy Department at Brooke Army Medical Center. NR 38 TC 7 Z9 7 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD OCT PY 2010 VL 34 IS 4 BP 364 EP 368 DI 10.1097/SHK.0b013e3181d8844b PG 5 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 651EN UT WOS:000281907800008 PM 20160662 ER PT J AU Derue, DS Barnes, CM Morgeson, FP AF DeRue, D. Scott Barnes, Christopher M. Morgeson, Frederick P. TI Understanding the Motivational Contingencies of Team Leadership SO SMALL GROUP RESEARCH LA English DT Article DE teams; leadership; motivation ID MANAGING WORK TEAMS; INDIVIDUAL-DIFFERENCES; EXTERNAL LEADERSHIP; MANAGEMENT TEAMS; JOB DESIGN; EFFICACY; PERFORMANCE; BEHAVIOR; METAANALYSIS; EVENTS AB Despite increased research on team leadership, little is known about the conditions under which coaching versus directive forms of team leadership are more effective, or the processes through which team leadership styles influence team outcomes. In the present study, the authors found that coaching leadership was more effective than directive leadership when the team leader was highly charismatic and less effective than directive leadership when the team leader lacked charisma. Directive leadership was more effective than coaching leadership when team members were high in self-efficacy and less effective than coaching leadership when team members lacked self-efficacy. The moderating effects of leader charisma and team member self-efficacy were mediated through motivational pathways involving team member effort. C1 [DeRue, D. Scott] Univ Michigan, Stephen M Ross Sch Business, Ann Arbor, MI 48109 USA. [Barnes, Christopher M.] US Mil Acad W Point, Army Ctr Excellence, New York, NY USA. [Morgeson, Frederick P.] Michigan State Univ, Eli Broad Coll Business, E Lansing, MI 48824 USA. RP Derue, DS (reprint author), Univ Michigan, Stephen M Ross Sch Business, Ann Arbor, MI 48109 USA. EM dsderue@umich.edu RI Barnes, Christopher/O-4814-2014 OI Barnes, Christopher/0000-0003-2520-6200 NR 70 TC 15 Z9 15 U1 11 U2 41 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1046-4964 J9 SMALL GR RES JI Small Group Res. PD OCT PY 2010 VL 41 IS 5 BP 621 EP 651 DI 10.1177/1046496410373808 PG 31 WC Psychology, Applied; Management; Psychology, Social SC Psychology; Business & Economics GA 649UB UT WOS:000281798300005 ER PT J AU Sampath, AV Garrett, GA Readinger, ED Enck, RW Shen, H Wraback, M Grandusky, JR Schowalter, LJ AF Sampath, A. V. Garrett, G. A. Readinger, E. D. Enck, R. W. Shen, H. Wraback, M. Grandusky, J. R. Schowalter, L. J. TI Characterization of nanometer scale compositionally inhomogeneous AlGaN active regions on bulk AlN substrates SO SOLID-STATE ELECTRONICS LA English DT Article; Proceedings Paper CT International Semiconductor Device Research Symposium (ISDRS 2009) CY DEC 09-11, 2009 CL Univ Maryland, Stamp Union, College Pk, MD HO Univ Maryland, Stamp Union DE Ultraviolet light emitting diodes; III-Nitrides; Defects; Radiative lifetime ID LUMINESCENCE EFFICIENCY; GROWTH; STRAIN; LAYERS AB The optical and structural properties of AlGaN active regions containing nanoscale compositional inhomogeneities (NCI) grown on low dislocation density bulk AlN substrates are reported. These substrates are found to improve the internal quantum efficiency and structural quality of NCI-AlGaN active regions for high Al content alloys, as well as the interfaces of the NCI with the surrounding wider bandgap matrix, as manifested in the absence of any significant long decay component of the low temperature radiative lifetime, which is well characterized by a single exponential photoluminescence decay with a 330 ps time constant. However, room temperature results indicate that non-radiative recombination associated with the high point defect density becomes a limiting factor in these films even at low dislocation densities for larger AlN mole fractions. Published by Elsevier Ltd. C1 [Sampath, A. V.; Garrett, G. A.; Readinger, E. D.; Enck, R. W.; Shen, H.; Wraback, M.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Grandusky, J. R.; Schowalter, L. J.] Crystal IS Inc, Green Isl, NY 12183 USA. RP Sampath, AV (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM anand.sampath@us.army.mil NR 13 TC 7 Z9 7 U1 1 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD OCT PY 2010 VL 54 IS 10 SI SI BP 1130 EP 1134 DI 10.1016/j.sse.2010.05.006 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 640AL UT WOS:000281019100015 ER PT J AU Chan, JC Tran, H Pattison, JW Rananavare, SB AF Chan, Joo C. Tran, Hoang Pattison, James W. Rananavare, Shankar B. TI Facile pyrolytic synthesis of silicon nanowires SO SOLID-STATE ELECTRONICS LA English DT Article; Proceedings Paper CT International Semiconductor Device Research Symposium (ISDRS 2009) CY DEC 09-11, 2009 CL Univ Maryland, Stamp Union, College Pk, MD HO Univ Maryland, Stamp Union DE Silicon nanowires; Dopants; Photoluminescence; Gold nanoparticles; HR-TEM ID OXIDE-ASSISTED GROWTH; OPTICAL-PROPERTIES; LASER-ABLATION; SOLAR-CELLS; POROUS SILICON; SI NANOWIRES; NANOSTRUCTURES; TEMPERATURE; TECHNOLOGY; MECHANISM AB One-dimensional nanostructures such as silicon nanowires (SiNW) are attractive candidates for low power density electronic and optoelectronic devices including sensors. A new simple method for SiNW bulk synthesis [1,2] is demonstrated in this work, which is inexpensive and uses low toxicity materials, thereby offering a safe, energy efficient and green approach. The method uses low flammability liquid phenylsilanes, offering a safer avenue for SiNW growth compared with using silane gas. A novel, duo-chamber glass vessel is used to create a low-pressure environment where SiNWs are grown through vapor-liquid-solid mechanism using gold nanoparticles as a catalyst. The catalyst decomposes silicon precursor vapors of diphenylsilane and triphenylsilane and precipitates single crystal SiNWs, which appear to grow parallel to the substrate surface. This opens up possibilities for synthesizing nano-junctions amongst wires which is important for the grid architecture of nanoelectronics proposed by Likharev [3]. Even bulk synthesis of SiNW is feasible using sacrificial substrates such as CaCO(3) that can be dissolved post-synthesis. Furthermore, by dissolving appropriate dopants in liquid diphenylsilane, a controlled doping of the nanowires is realized without the use of toxic gases and expensive mass flow controllers. Upon boron doping, we observe a characteristic red shift in photoluminescence spectra. In summary, an inexpensive and versatile method for SiNW is presented that makes these exotic materials available to any lab at low cost. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Tran, Hoang; Rananavare, Shankar B.] Portland State Univ, Dept Chem, Portland, OR 97207 USA. [Chan, Joo C.] Intel Corp, Adv Log Components, Hillsboro, OR 97124 USA. [Pattison, James W.] USA, Res Lab, Adelphi Lab Ctr, Adelphi, MD 20783 USA. RP Rananavare, SB (reprint author), Portland State Univ, Dept Chem, Portland, OR 97207 USA. EM joo.c.chan@intel.com; hoangt@pdx.edu; james.pattison1@arl.army.mil; ranavas@pdx.edu RI Rananavare, Shankar/A-8698-2009 OI Rananavare, Shankar/0000-0003-2564-4673 FU NHLBI NIH HHS [R01 HL054209, R01 HL054209-10] NR 56 TC 2 Z9 2 U1 0 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD OCT PY 2010 VL 54 IS 10 SI SI BP 1185 EP 1191 DI 10.1016/j.sse.2010.05.011 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 640AL UT WOS:000281019100023 PM 20711489 ER PT J AU Nguyen, C Shah, P Leong, E Derenge, M Jones, K AF Nguyen, Cuong Shah, Pankaj Leong, Edward Derenge, Michael Jones, Kenneth TI Si implant-assisted Ohmic contacts to GaN SO SOLID-STATE ELECTRONICS LA English DT Article; Proceedings Paper CT International Semiconductor Device Research Symposium (ISDRS 2009) CY DEC 09-11, 2009 CL Univ Maryland, Stamp Union, College Pk, MD HO Univ Maryland, Stamp Union DE GaN; Ohmic contacts; Ion implantation; Annealing cap ID ION-IMPLANTATION; ACTIVATION; MOBILITY; HEMTS AB The contact resistance, rho(C), was measured for the traditional Ti/Al/Ni/Au Ohmic contact for samples implanted with Si to > 10(20) cm(-3) and annealed at 1100, 1150, 1200, or 1250 degrees C for 2, 5 or 10 min using an AlN annealing cap. These results are compared with those for samples annealed in the same way, but were not implanted. The as-grown samples were doped to 3.56 x 10(17) or 6.67 x 10(16) cm(-3) or were unintentionally (UI) doped. In almost all cases, rho(C) for the implanted sample was lower, and a record low rho(C) = 2.66 x 10(-8) Omega cm(2) was achieved for the more heavily doped implanted sample annealed at 1200 degrees C for 10 min. rho(C) decreased with the doping concentration, and for the Ul samples, Ohmic contacts could be made only if the samples were implanted. The surface roughness was also measured, and it was found for an as-grown with an RMS roughness of 0.303 nm, the roughness increased from 0.623 after an 1100 degrees C anneal to 3.197 nm after a 1250 degrees C anneal for the implanted samples annealed for 10 min, and it increased from 1.280 nm to 5.357 nm under the same conditions for the samples that were not implanted. Published by Elsevier Ltd. C1 [Nguyen, Cuong; Shah, Pankaj; Leong, Edward; Derenge, Michael; Jones, Kenneth] USA, Res Lab, SEDD, Adelphi, MD 20783 USA. [Nguyen, Cuong; Leong, Edward] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RP Nguyen, C (reprint author), USA, Res Lab, SEDD, Adelphi, MD 20783 USA. EM cuong.nguyen8@arl.army.mil NR 16 TC 4 Z9 4 U1 2 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD OCT PY 2010 VL 54 IS 10 SI SI BP 1227 EP 1231 DI 10.1016/j.sse.2010.05.014 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 640AL UT WOS:000281019100030 ER PT J AU Ogunniyi, A O'Brien, H Lelis, A Scozzie, C Shaheen, W Agarwal, A Zhang, J Callanan, R Temple, V AF Ogunniyi, Aderinto O'Brien, Heather Lelis, Aivars Scozzie, Charles Shaheen, William Agarwal, Anant Zhang, Jon Callanan, Robert Temple, Victor TI The benefits and current progress of SiC SGTOs for pulsed power applications SO SOLID-STATE ELECTRONICS LA English DT Article; Proceedings Paper CT International Semiconductor Device Research Symposium (ISDRS 2009) CY DEC 09-11, 2009 CL Univ Maryland, Stamp Union, College Pk, MD HO Univ Maryland, Stamp Union DE SiC GTOs; Pulsed power; Carrier lifetime; Basal plane dislocation; Micropipe AB Silicon Carbide (SiC) is an extremely attractive material for semiconductor power devices because of its electrical and physical characteristics. This paper describes the benefits of utilizing SiC Super Gate Turn-Off thyristors (SGTO) in pulsed power applications, reviews the current progress and development of SIC GTOs, and presents the static and pulsed characteristics of large area GTOs with high blocking capabilities. The wide pulsed evaluation of the 0.5 cm(2) SiC SGTOs has been demonstrated and reported by the Army Research Laboratory (ARL). This paper presents the wide pulsed capabilities of the 1 cm(2) SiC SGTOs. The 1 cm(2) SiC SGTO devices handled up to twice the peak current of the 0.5 cm(2) SiC SGTOs at a 1 ms pulse width. The wide pulsed evaluation of these devices was demonstrated at ARL. ARL evaluated the static and pulsed characteristics of six of these devices. The devices had a forward blocking voltage rating of 9 kV and a trigger requirement of a negative pulse of 1 A to the gate for a millisecond pulse width. These devices were pulsed as high as 3.5 kA at 1 ms, equating to an action rate of 6 x 10(3) A(2) s and a current density of 4.8 kA/cm(2), based on the device active area. The narrow pulsed evaluation of this device has been demonstrated by Cree Inc. A peak current of 12.8 kA with a pulse width of 17 mu s (corresponding to 12.8 kA/cm(2) based on the chip size) was conducted with this device. Published by Elsevier Ltd. C1 [Ogunniyi, Aderinto; O'Brien, Heather; Lelis, Aivars; Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA. [Shaheen, William] Berkeley Res Associates Inc, Beltsville, MD 20705 USA. [Agarwal, Anant; Zhang, Jon; Callanan, Robert] Cree Inc, Durham, NC 27703 USA. [Temple, Victor] Silicon Power Corp, Clifton Pk, NY 12065 USA. RP Ogunniyi, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM aderinto.ogunniyi@arl.army.mil NR 8 TC 18 Z9 19 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD OCT PY 2010 VL 54 IS 10 SI SI BP 1232 EP 1237 DI 10.1016/j.sse.2010.05.018 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 640AL UT WOS:000281019100031 ER PT J AU Cardoso, MJ Helgeson, MD Paik, H Dmitriev, AE Lehman, RA Rosner, MK AF Cardoso, Mario J. Helgeson, Melvin D. Paik, Haines Dmitriev, Anton E. Lehman, Ronald A., Jr. Rosner, Michael K. TI Structures at risk from pedicle screws in the proximal thoracic spine: computed tomography evaluation SO SPINE JOURNAL LA English DT Article DE Pedicle screws; Thoracic spine; Esophagus; Trachea ID IDIOPATHIC SCOLIOSIS; PLACEMENT; FIXATION; INSTRUMENTATION; AORTA; SAFE; ACCURACY AB BACKGROUND CONTEXT: Pedicle screw placement in the proximal thoracic spine may result in unwanted bicortical breach. An understanding of the potential structures at risk is paramount to safe screw placement. PURPOSE: To assess the anatomic location of structures at risk with the placement of bicortical pedicle screw fixation in the proximal thoracic spine. STUDY DESIGN: Retrospective radiographic review. PATIENT SAMPLE: Twenty patients with dedicated computed tomography (CT) scans of the thoracic spine. OUTCOME MEASURES: Radiographic parameters on CT. METHODS AND MATERIALS: Computed tomography was performed on 20 patients and analyzed from T1 to T4 for proximity of major structures at risk with breach of the anterior vertebral body cortex from pedicle screw placement. Descriptive statistics, analyses of variance and post hoc paired t tests were used to analyze screw position relative to the esophagus, trachea, aortic arch, carotid, and vertebral arteries. RESULTS: One hundred sixty potential anterior cortical violation positions were analyzed. Left-sided pedicle screws posed a significantly higher risk (p<.05) to the esophagus at T1-T3; in particular, the left T2 screw was significantly closer (p<.05). Right-sided pedicle screws posed a significantly higher risk to the trachea at T2 T4 (p<.05). The right T3 and T4 screws posed the greatest risk to the trachea and right main bronchus, respectively (p<.05). The carotid and vertebral arteries were not at risk for injury. The aortic arch was present at T4 in 70% of patients and was not at risk. CONCLUSIONS: Careful preoperative evaluation with CT is warranted to determine anatomic structures at risk when placing proximal thoracic pedicle screws. Left-sided screws pose the greatest risk to the esophagus; right-sided screws pose the greatest risk to the trachea. The carotid and vertebral arteries, along with the aortic arch are at minimal risk for injury. Published by Elsevier Inc. C1 [Helgeson, Melvin D.; Paik, Haines; Dmitriev, Anton E.; Lehman, Ronald A., Jr.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Cardoso, Mario J.; Rosner, Michael K.] Walter Reed Army Med Ctr, Neurosurg Serv, Washington, DC 20307 USA. RP Paik, H (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave, Washington, DC 20307 USA. EM haines.paik@gmail.com NR 17 TC 6 Z9 7 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD OCT PY 2010 VL 10 IS 10 BP 905 EP 909 DI 10.1016/j.spinee.2010.08.020 PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 667JX UT WOS:000283190400009 PM 20869005 ER PT J AU Pickett, CA Jackson, JL Hemann, BA Atwood, JE AF Pickett, Christopher A. Jackson, Jeffrey L. Hemann, Brian A. Atwood, J. Edwin TI Carotid Bruits and Cerebrovascular Disease Risk A Meta-Analysis SO STROKE LA English DT Article DE atherosclerosis; carotid bruit; prognosis; stroke; TIA ID ASYMPTOMATIC CERVICAL BRUIT; ARTERY STENOSIS; FOLLOW-UP; SYSTEMATIC REVIEWS; NATURAL-HISTORY; CLINICAL-TRIALS; ISCHEMIC-STROKE; NECK BRUITS; ENDARTERECTOMY; MANAGEMENT AB Background and Purpose-Current guidelines recommend against routine auscultation of carotid arteries, believing that carotid bruits are poor predictors of either underlying carotid stenosis or stroke risk in asymptomatic patients. We investigated whether the presence of a carotid bruit is associated with increased risk for transient ischemic attack, stroke, or death by stroke (stroke death). Methods-We searched Medline (1966 to December 2009) and EMBASE (1974 to December 2009) with the terms "carotid" and "bruit." Bibliographies of all retrieved articles were also searched. Articles were included if they prospectively reported the incidence of transient ischemic attack, stroke, or stroke death in asymptomatic adults. Two authors independently reviewed and extracted data. Results-We included 28 prospective cohort articles that followed a total of 17 913 patients for 67 708 patient-years. Among studies that directly compared patients with and without bruits, the rate ratio for transient ischemic attack was 4.00 (95% CI, 1.8 to 9.0, P<0.0005, n=5 studies), stroke was 2.5 (95% CI, 1.8 to 3.5, P<0.0005, n=6 studies), and stroke death was 2.7 (95% CI, 1.33 to 5.53, P=0.002, n=3 studies). Among the larger pool of studies that provided data on rates, transient ischemic attack rates were 2.6 per 100 patient-years (95% CI, 2.0 to 3.2, P<0.0005, n=24 studies) for those with bruits compared with 0.9 per 100 patient-years (95% CI, 0.2 to 1.6, P=0.02, n=5 studies) for those without carotid bruits. Stroke rates were 1.6 per 100 patient-years (95% CI, 1.3 to 1.9, P<0.0005, n=26 studies) for those with bruits compared with 1.3 per 100 patient-years (95% CI, 0.8 to 1.7, P<0.0005, n=6) without carotid bruits, and death rates were 0.32 (95% CI, 0.20 to 0.44, P<0.005, n=13 studies) for those with bruits compared with 0.35 (95% CI, 0.00 to 0.81, P=0.17, n=3 studies) for those without carotid bruits. Conclusion-The presence of a carotid bruit may increase the risk of cerebrovascular disease. (Stroke. 2010;41:2295-2302.) C1 [Pickett, Christopher A.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. [Hemann, Brian A.; Atwood, J. Edwin] Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. [Jackson, Jeffrey L.] Zablocki VA Med Ctr, Div Gen Med, Milwaukee, WI USA. RP Pickett, CA (reprint author), US Mil Acad, Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM christopher.pickett1@us.army.mil NR 53 TC 11 Z9 12 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0039-2499 J9 STROKE JI Stroke PD OCT PY 2010 VL 41 IS 10 BP 2295 EP 2302 DI 10.1161/STROKEAHA.110.585554 PG 8 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA 655CY UT WOS:000282221700041 PM 20724720 ER PT J AU Hulitt, E Vaughn, RB AF Hulitt, Elaine Vaughn, Rayford B. TI Information system security compliance to FISMA standard: a quantitative measure SO TELECOMMUNICATION SYSTEMS LA English DT Article; Proceedings Paper CT The International Workshop on Secure Information Systems (SIS) CY OCT 20-22, 2008 CL Wisla, POLAND DE Risk analysis; Secure architecture modeling; Standards compliance modeling; Pathfinder networks; RMF; FISMA AB To ensure that safeguards are implemented to protect against a majority of known threats, industry leaders are requiring information processing systems to comply with security standards. The National Institute of Standards and Technology Federal Information Risk Management Framework (RMF) and the associated suite of guidance documents describe the minimum security requirements (controls) for non-national-security federal information systems mandated by the Federal Information Security Management Act (FISMA), enacted into law on December 17, 2002, as Title III of the E-Government Act of 2002. The subjective compliance assessment approach described in the RMF guidance, though thorough and repeatable, lacks the clarity of a standard quantitative metric to describe for an information system the level of compliance with the FISMA-required standard. Given subjective RMF assessment data, this article suggests the use of Pathfinder networks to generate a quantitative metric suitable to measure, manage, and track the status of information system compliance with FISMA. C1 [Hulitt, Elaine] USA, Engineer Res & Dev Ctr, CEERD IS, Vicksburg, MS 39180 USA. [Vaughn, Rayford B.] Mississippi State Univ, Dept Comp Sci & Engn, Ctr Comp Secur Res, Starkville, MS 39762 USA. RP Hulitt, E (reprint author), USA, Engineer Res & Dev Ctr, CEERD IS, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Elaine.Hulitt@usace.army.mil; Vaughn@cse.msstate.edu NR 28 TC 4 Z9 6 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1018-4864 EI 1572-9451 J9 TELECOMMUN SYST JI Telecommun. Syst. PD OCT PY 2010 VL 45 IS 2-3 SI SI BP 139 EP 152 DI 10.1007/s11235-009-9248-8 PG 14 WC Telecommunications SC Telecommunications GA 652NC UT WOS:000282012700005 ER PT J AU Nikolich, MP Warren, RL Lindler, LE Izadjoo, MJ Hoover, DL AF Nikolich, Mikeljon P. Warren, Richard L. Lindler, Luther E. Izadjoo, Mina J. Hoover, David L. TI Attenuation of defined Brucella melitensis wboA mutants SO VACCINE LA English DT Article; Proceedings Paper CT Brucellosis as a Transboudary Infection of Animals and Humans which Needs to be Managed by Cooperative Efforts of Different Countries CY JUN, 2008 CL Serpukhov, RUSSIA DE Brucella; Live attenuated; Vaccine candidate; Defined rough mutant ID INTRACELLULAR SURVIVAL; DEOXYRIBONUCLEIC-ACID; O-POLYSACCHARIDE; BALB/C MICE; ABORTUS; LIPOPOLYSACCHARIDE; MACROPHAGES; INFECTION; SUIS; GENE AB Rough Brucella mutants have been sought as vaccine candidates because they do not induce seroconversion. In this study, two defined nonreverting rough mutants were derived from virulent Brucella melitensis strain 16M: a wboA deletion mutant designated WRR51 and a wboA purEK dual deletion mutant designated WRRP1. Strain WRRP1 exhibited reduced survival in human monocyte-derived macrophages (hMDMs) compared with parent strain WRR51 or with Delta purEK strain WR201. Strain WRRP1 persisted for 1 week or less in BALB/c mice after intraperitoneal infection, while less severe attenuation was exhibited by the two single mutants in this model. Trans complementation of wboA restored the survival of WRR51 in hMDMs comparable to strain 16M and the survival of WRRP1 comparable to strain WR201. Published by Elsevier Ltd. C1 [Nikolich, Mikeljon P.; Hoover, David L.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Warren, Richard L.] Battelle Mem Inst, Columbus, OH 43201 USA. [Lindler, Luther E.] Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. [Izadjoo, Mina J.] Armed Forces Inst Pathol, Washington, DC 20306 USA. RP Nikolich, MP (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM mikeljon.nikolich@amedd.army.mil RI Nikolich, Mikeljon/B-2868-2011 NR 33 TC 3 Z9 4 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 1 PY 2010 VL 28 SU 5 BP F12 EP F16 DI 10.1016/j.vaccine.2010.03.058 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 675KW UT WOS:000283830600004 PM 20362622 ER PT J AU Andrews, GP Vernati, G Ulrich, R Rocke, TE Edwards, WH Adamovicz, JJ AF Andrews, Gerard P. Vernati, Giulia Ulrich, Ricky Rocke, Tonie E. Edwards, William H. Adamovicz, Jeffrey J. TI Identification of In Vivo-Induced Conserved Sequences from Yersinia pestis During Experimental Plague Infection in the Rabbit SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Plague; Yersinia; Immunology; Diagnostics ID ANTIGEN TECHNOLOGY IVIAT; PROTECTIVE EFFICACY; SECRETION SYSTEM; PNEUMONIC PLAGUE; BUBONIC PLAGUE; AUTOTRANSPORTER PROTEINS; LEGIONELLA-PNEUMOPHILA; VIBRIO-CHOLERAE; FUSION PROTEIN; OUTER PROTEINS AB In an effort to identify the novel virulence determinants of Yersinia pestis, we applied the gene "discovery'' methodology, in vivo-induced (IVI) antigen technology, to detect genes upregulated during infection in a laboratory rabbit model for bubonic plague. After screening over 70,000 Escherichia coli clones of Y. pestis DNA expression libraries, products from 25 loci were identified as being seroreactive to reductively adsorbed, pooled immune serum. Upon sequence analysis of the predicted IVI gene products, more frequently encountered conserved protein functional categories have emerged, to include type-V autotransporters and components of more complex secretion systems including types III and VI. The recombinant products from eight selected clones were subsequently immunoblotted against pooled immune serum from two naturally infected host species: the prairie dog, and a species refractory to lethal disease, the coyote. Immune prairie dog serum recognized 2-3 of the rabbit-reactive antigens, suggesting at least some overlap in the pathogen's in vivo survival mechanisms between these two hosts. Although the coyote serum failed to recognize most of the IVI antigens, LepA was universally reactive with all three host sera. Collectively, the profiles/patterns of IVI conserved sequences (IVICS) may represent immune "signatures'' among different host species, possessing the potential for use as a diagnostic tool for plague. Further, the antigenic nature of IVICS makes them ideal for further evaluation as novel subunit vaccine candidates. The gathering of additional data and analysis of the intact IVI genes and the expressed IVICS products should provide insight into the unique biologic processes of Y. pestis during infection and reveal the genetic patterns of the pathogen's survival strategy in different hosts. C1 [Andrews, Gerard P.] Univ Wyoming, Wyoming State Vet Lab, Dept Vet Sci, Laramie, WY 82070 USA. [Ulrich, Ricky] USA, Bacteriol Div, Inst Infect Dis, Ft Detrick, MD USA. [Rocke, Tonie E.] US Geol Serv, Natl Wildlife Hlth Ctr, Madison, WI USA. [Edwards, William H.] Wyoming State Game & Fish, Laramie, WY USA. RP Andrews, GP (reprint author), Univ Wyoming, Wyoming State Vet Lab, Dept Vet Sci, 1174 Snowy Range Rd, Laramie, WY 82070 USA. EM gandrews@uwyo.edu OI Rocke, Tonie/0000-0003-3933-1563 FU U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) [W81XWH-05-0047] FX The authors thank Steven Little and Amy Permenter for their excellent technical help, as well as Kim Andrews for her critical review of this manuscript. This study was supported by the U.S. Army Medical Research Institute of Infectious Diseases Cooperative Research and Development Agreement (USAMRIID CRDA; no. W81XWH-05-0047). NR 39 TC 6 Z9 6 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD OCT PY 2010 VL 10 IS 8 BP 749 EP 756 DI 10.1089/vbz.2009.0179 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 669NT UT WOS:000283358200006 PM 20055582 ER PT J AU Daddis, GA AF Daddis, Gregory A. TI Beyond the Brotherhood: Reassessing US Army Combat Relationships in the Second World War SO WAR & SOCIETY LA English DT Article DE unit cohesion; combat motivation; organizational theory; military sociology; service culture AB The conventional wisdom that portrays US combat soldiers in World War II as a 'band of brothers' owes much to Hollywood and popular history, and distorts serious understanding of the relationships within combat units of the US Army. This article examines this idea in the context of theories of unit cohesion and combat motivation and suggests a more complex understanding of these issues. C1 Care of Daddis LC, US Mil Acad, West Point, NY 10996 USA. RP Daddis, GA (reprint author), Care of Daddis LC, US Mil Acad, West Point, NY 10996 USA. EM Gregory.Daddis@usma.edu NR 72 TC 0 Z9 0 U1 0 U2 0 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 0729-2473 J9 WAR SOC JI War Soc. PD OCT PY 2010 VL 29 IS 2 BP 97 EP 117 DI 10.1179/204243410X12796373846301 PG 21 WC History SC History GA V24QO UT WOS:000208425100001 ER PT J AU Novy, A Smouse, PE Hartman, JM Struwe, L Honig, J Miller, C Alvarez, M Bonos, S AF Novy, Ari Smouse, Peter E. Hartman, Jean Marie Struwe, Lena Honig, Josh Miller, Chris Alvarez, Melissa Bonos, Stacy TI Genetic Variation of Spartina alterniflora in the New York Metropolitan Area and Its Relevance for Marsh Restoration (vol 30, pg 603, 2010) SO WETLANDS LA English DT Correction C1 [Novy, Ari; Struwe, Lena; Honig, Josh; Bonos, Stacy] Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol & Pathol, New Brunswick, NJ 08901 USA. [Novy, Ari; Hartman, Jean Marie] Rutgers State Univ, Sch Environm & Biol Sci, Dept Landscape Architecture, New Brunswick, NJ 08901 USA. [Smouse, Peter E.; Struwe, Lena] Rutgers State Univ, Sch Environm & Biol Sci, Dept Ecol Evolut & Nat Resources, New Brunswick, NJ 08901 USA. [Miller, Chris] NRCS Plant Mat Ctr, USDA, Cape May, NJ USA. [Alvarez, Melissa] USA, Corps Engn, New York, NY USA. RP Novy, A (reprint author), Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol & Pathol, Rm 273,Foran Hall, New Brunswick, NJ 08901 USA. EM arinovy@rci.rutgers.edu NR 1 TC 0 Z9 0 U1 1 U2 7 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 J9 WETLANDS JI Wetlands PD OCT PY 2010 VL 30 IS 5 BP 1007 EP 1007 DI 10.1007/s13157-010-0086-y PG 1 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 691VW UT WOS:000285109900017 ER PT J AU Mo, TT Mi, XL Milner, EE Dow, GS Wipf, P AF Mo, Tingting Mi, Xueling Milner, Erin E. Dow, Geoffrey S. Wipf, Peter TI Synthesis of an 8-pentafluorosulfanyl analog of the antimalarial agent mefloquine SO TETRAHEDRON LETTERS LA English DT Article ID ETHYNYLSULFUR PENTAFLUORIDE; CEREBRAL UPTAKE; DERIVATIVES; MALARIA; SUBSTITUENTS; ENANTIOMERS; CHLOROQUINE; ANTAGONISTS; FALCIPARUM; DISCOVERY AB The 8-SF(5) analog of mefloquine was synthesized in nine steps from commercially available starting materials and in five steps from a novel ortho-SF(5)-substituted aniline intermediate. (c) 2010 Elsevier Ltd. All rights reserved. C1 [Mo, Tingting; Mi, Xueling; Wipf, Peter] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. [Mo, Tingting; Mi, Xueling; Wipf, Peter] Univ Pittsburgh, Ctr Chem Methodol & Lib Dev, Pittsburgh, PA 15260 USA. [Milner, Erin E.; Dow, Geoffrey S.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Wipf, P (reprint author), Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. EM pwipf@pitt.edu FU Medicines for Malaria Venture (MMV); Military Infectious Diseases Research Program (MIDRP) FX We thank the Military Infectious Diseases Research Program (MIDRP) and Medicines for Malaria Venture (MMV) for financial support. This Letter was reviewed by the Walter Reed Army Institute of Research and the US Army Medical Research and Materiel Command, and there is no objection to its publication or dissemination. The opinions expressed herein are those of the authors and do not reflect the views or opinions of the Department of the Army or the Department of Defense. NR 46 TC 31 Z9 31 U1 2 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD SEP 29 PY 2010 VL 51 IS 39 BP 5137 EP 5140 DI 10.1016/j.tetlet.2010.07.113 PG 4 WC Chemistry, Organic SC Chemistry GA 654EH UT WOS:000282150800011 ER PT J AU Levy, EC Okusaga, O Horowitz, M Menyuk, CR Zhou, WM Carter, GM AF Levy, Etgar C. Okusaga, Olukayode Horowitz, Moshe Menyuk, Curtis R. Zhou, Weimin Carter, Gary M. TI Comprehensive computational model of single- and dual-loop optoelectronic oscillators with experimental verification SO OPTICS EXPRESS LA English DT Article ID PHASE-NOISE AB We describe a comprehensive computational model for single-loop and dual-loop optoelectronic oscillators ( OEOs). The model takes into account the dynamical effects and noise sources that are required to accurately model OEOs. By comparing the computational and experimental results in a single-loop OEO, we determined the amplitudes of the white noise and flicker noise sources. We found that the flicker noise source contains a strong component that linearly depends on the loop length. Therefore, the flicker noise limits the performance of long-cavity OEOs ( greater than or similar to 5 km) at low frequencies ( f < 500 Hz). The model for a single-loop OEO was extended to model the dual-loop injection-locked OEO ( DIL-OEO). The model gives the phase-noise, the spur level, and the locking range of each of the coupled loops in the OEO. An excellent agreement between theory and experiment is obtained for the DIL-OEO. Due to its generality and accuracy, the model is important for both designing OEOs and studying the physical effects that limit their performance. We demonstrate theoretically that it is possible to reduce the first spur in the DIL-OEO by more than 20 dB relative to its original performance by changing its parameters. This theoretical result has been experimentally verified. (C) 2010 Optical Society of America C1 [Levy, Etgar C.; Horowitz, Moshe] Technion Israel Inst Technol, Dept Elect Engn, IL-32000 Haifa, Israel. [Menyuk, Curtis R.; Carter, Gary M.] Univ Maryland, Dept Elect Engn, Baltimore, MD 21250 USA. [Okusaga, Olukayode; Zhou, Weimin] US Army Res Lab, Adelphi, MD USA. RP Levy, EC (reprint author), Technion Israel Inst Technol, Dept Elect Engn, IL-32000 Haifa, Israel. EM etgarlevy@gmail.com FU DARPA MTO FX This work is supported by DARPA MTO. NR 11 TC 22 Z9 24 U1 1 U2 14 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 27 PY 2010 VL 18 IS 20 BP 21461 EP 21476 DI 10.1364/OE.18.021461 PG 16 WC Optics SC Optics GA 673QX UT WOS:000283679200093 PM 20941042 ER PT J AU Khedir, KR Kannarpady, GK Ishihara, H Woo, J Ryerson, C Biris, AS AF Khedir, Khedir R. Kannarpady, Ganesh K. Ishihara, Hidetaka Woo, Justin Ryerson, Charles Biris, Alexandru S. TI Morphology control of tungsten nanorods grown by glancing sputtering under variable argon pressure and flow rate angle RF magnetron SO PHYSICS LETTERS A LA English DT Article DE Tungsten nanorods; Glancing angle deposition; RF magnetron sputtering; Phase transformation; Morphology control ID CU THIN-FILMS; PILLAR MICROSTRUCTURE; DEPOSITION AB Morphologically novel tungsten nanorods (WNRs) with the co-existence of two crystalline phases, alpha-W (thermodynamically stable) and beta-W, were fabricated by glancing angle RF magnetron sputtering technique under various Ar pressures and flow rates. For these nanorods, a significant variation in their morphology and surface roughness was observed. These structures could be useful in a wide range of applications such as field emission, robust superhydrophobic coatings, energy, and medicine. (C) 2010 Elsevier B.V. All rights reserved. C1 [Khedir, Khedir R.; Kannarpady, Ganesh K.; Ishihara, Hidetaka; Woo, Justin; Biris, Alexandru S.] Univ Arkansas, Nanotechnol Ctr, Little Rock, AR 72204 USA. [Ryerson, Charles] Ctr USA Corps Engineers, Terr & Cryospher Sci Branch Cold Reg, Res & Engn Lab Engineer Res & Dev, Hanover, NH 03755 USA. RP Kannarpady, GK (reprint author), Univ Arkansas, Nanotechnol Ctr, 2801 S Univ Ave, Little Rock, AR 72204 USA. EM gkkannarpady@ualr.edu; asbiris@ualr.edu RI Biris, Alexandru/A-8507-2010 FU US Army (ERDC) [W912HZ-09-02-0008]; Arkansas Science & Technology Authority [08-CAT-03]; Department of Energy [DE-FG36-06G086072] FX Financial support from US Army (ERDC Cooperative Agreement Number: W912HZ-09-02-0008), Arkansas Science & Technology Authority (Grant # 08-CAT-03), and Department of Energy (DE-FG36-06G086072) is greatly appreciated. NR 29 TC 10 Z9 10 U1 2 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9601 EI 1873-2429 J9 PHYS LETT A JI Phys. Lett. A PD SEP 27 PY 2010 VL 374 IS 43 BP 4430 EP 4437 DI 10.1016/j.physleta.2010.08.066 PG 8 WC Physics, Multidisciplinary SC Physics GA 662YR UT WOS:000282850700010 ER PT J AU Holtman, KM Chen, N Chappell, MA Kadla, JF Xu, L Mao, JD AF Holtman, Kevin M. Chen, Na Chappell, Mark A. Kadla, John F. Xu, Ling Mao, Jingdong TI Chemical Structure and Heterogeneity Differences of Two Lignins from Loblolly Pine As Investigated by Advanced Solid-State NMR Spectroscopy SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE Milled wood lignin; solid-state NMR; heterogeneity; spin diffusion; spectral editing ID NUCLEAR-MAGNETIC-RESONANCE; CELLULOLYTIC ENZYME LIGNIN; MILLED WOOD LIGNIN; ORGANIC-MATTER; HUMIC ACIDS AB Advanced solid-state NMR was employed to investigate differences in chemical structure and heterogeneity between milled wood lignin (MWL) and residual enzyme lignin (REL). Wiley and conventional milled woods were also studied. The advanced NMR techniques included C-13 quantitative direct polarization, various spectral-editing techniques, and two-dimensional H-1-C-13 heteronuclear correlation NMR with H-1 spin diffusion. The C-13 chemical shift regions between 110 and 160 ppm of two lignins were quite similar to those of two milled woods. REL contained much more residual carbohydrates than MWL, showing that MWL extraction more successfully separated lignin from cellulose and hemicelluloses than REL extraction; REL was also of higher COO, aromatic C-C, and condensed aromatics but of lower aromatic C-H. At a spin diffusion time of 0.55 ms, the magnetization was equilibrated through the whole structure of MWL lignin, but not through that of REL, indicating that REL is more heterogeneous than MWL. C1 [Chen, Na; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Holtman, Kevin M.] ARS, Western Reg Res Ctr, USDA, Albany, CA 94710 USA. [Chappell, Mark A.] USA, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. [Kadla, John F.] Univ British Columbia, Vancouver, BC V6T 1Z4, Canada. [Xu, Ling] James Madison Univ, Dept Math & Stat, Harrisonburg, VA 22807 USA. RP Mao, JD (reprint author), Old Dominion Univ, Dept Chem & Biochem, 4541 Hampton Blvd, Norfolk, VA 23529 USA. EM jmao@odu.edu FU National Science Foundation [EAR-0843996, CBET-0853950] FX We thank the National Science Foundation (EAR-0843996 and CBET-0853950) for financial support. NR 32 TC 17 Z9 20 U1 3 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 EI 1520-5118 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD SEP 22 PY 2010 VL 58 IS 18 BP 9882 EP 9892 DI 10.1021/jf101258x PG 11 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 649AB UT WOS:000281736000002 PM 20726583 ER PT J AU Gul, N Smith, LA Ahmed, SA AF Gul, Nizamettin Smith, Leonard A. Ahmed, S. Ashraf TI Light Chain Separated from the Rest of the Type A Botulinum Neurotoxin Molecule Is the Most Catalytically Active Form SO PLOS ONE LA English DT Article ID RECEPTOR-BINDING-SITE; HEAVY-CHAIN; SEROTYPE-A; SUBSTRATE RECOGNITION; STRUCTURAL-ANALYSIS; IDENTIFICATION; TRANSLOCATION; PROTEINS; CLEAVAGE; PROTEASE AB Botulinum neurotoxins (BoNT) are the most potent of all toxins. The 50 kDa N-terminal endopeptidase catalytic light chain (LC) of BoNT is located next to its central, putative translocation domain. After binding to the peripheral neurons, the central domain of BoNT helps the LC translocate into cytosol where its proteolytic action on SNARE (soluble NSF attachment protein receptor) proteins blocks exocytosis of acetyl choline leading to muscle paralysis and eventual death. The translocation domain also contains 105 angstrom -long stretch of similar to 100 residues, known as "belt,'' that crosses over and wraps around the LC to shield the active site from solvent. It is not known if the LC gets dissociated from the rest of the molecule in the cytosol before catalysis. To investigate the structural identity of the protease, we prepared four variants of type A BoNT (BoNT/A) LC, and compared their catalytic parameters with those of BoNT/A whole toxin. The four variants were LC + translocation domain, a trypsin-nicked LC + translocation domain, LC + belt, and a free LC. Our results showed that K(m) for a 17-residue SNAP-25 (synaptosomal associated protein of 25 kDa) peptide for these constructs was not very different, but the turnover number (k(cat)) for the free LC was 6-100-fold higher than those of its four variants. Moreover, none of the four variants of the LC was prone to autocatalysis. Our results clearly demonstrated that in vitro, the LC minus the rest of the molecule is the most catalytically active form. The results may have implication as to the identity of the active, toxic moiety of BoNT/A in vivo. C1 [Gul, Nizamettin; Smith, Leonard A.; Ahmed, S. Ashraf] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Smith, Leonard A.] USA, Med Res & Mat Command, Ft Detrick, MD USA. RP Gul, N (reprint author), CBMS, MITS, Ft Detrick, MD USA. EM syed.ahmed@amedd.army.mil FU Joint Science and Technology Office - Chemical and Biological Defense [CBS.MEDBIO.01.10.RD.002] FX The research described herein was supported by Joint Science and Technology Office - Chemical and Biological Defense project number CBS.MEDBIO.01.10.RD.002 to SAA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 44 TC 8 Z9 8 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 22 PY 2010 VL 5 IS 9 AR e12872 DI 10.1371/journal.pone.0012872 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 653AC UT WOS:000282053100024 PM 20877571 ER PT J AU Tsai, PC Bigley, A Li, YC Ghanem, E Cadieux, CL Kasten, SA Reeves, TE Cerasoli, DM Raushel, FM AF Tsai, Ping-Chuan Bigley, Andrew Li, Yingchun Ghanem, Eman Cadieux, C. Linn Kasten, Shane A. Reeves, Tony E. Cerasoli, Douglas M. Raushel, Frank M. TI Stereoselective Hydrolysis of Organophosphate Nerve Agents by the Bacterial Phosphotriesterase SO BIOCHEMISTRY LA English DT Article ID STEREOCHEMICAL SPECIFICITY; PSEUDOMONAS-DIMINUTA; ACTIVE-SITE; ANALOGS; SOMAN; PURIFICATION; PARAOXONASE; RESOLUTION; SUBSTRATE; RESIDUES AB Organophosphorus compounds include many synthetic, neurotoxic substances that are commonly used as insecticides. The toxicity of these compounds is due to their ability to inhibit the enzyme acetylcholine esterase. Some of the most toxic organophosphates have been adapted for use as chemical warfare agents; the most well-known are GA, GB, GD, GF, VX, and VR. All of these compounds contain a chiral phosphorus center, with the S(P) enantiomers being significantly more toxic than the R(P) enantiomers. Phosphotriesterase (PTE) is an enzyme capable of detoxifying these agents, but the stereochemical preference of the wild-type enzyme is for the R(P) enantiomers. A series of enantiomerically pure chiral nerve agent analogues containing the relevant phosphoryl centers found in GB, GD, GF, VX, and VR has been developed. Wild-type and mutant forms of PTE have been tested for their ability to hydrolyze this series of compounds. Mutant forms of PTE with significantly enhanced, as well as relaxed or reversed, stereoselectivity have been identified. A number of variants exhibited dramatically improved kinetic constants for the catalytic hydrolysis of the more toxic S(P) enantiomers. Improvements of up to 3 orders of magnitude relative to the value of the wild-type enzyme were observed. Some of these mutants were tested against racemic mixtures of GB and GD. The kinetic constants obtained with the chiral nerve agent analogues accurately predict the improved activity and stereoselectivity against the authentic nerve agents used in this study. C1 [Tsai, Ping-Chuan; Bigley, Andrew; Li, Yingchun; Ghanem, Eman; Raushel, Frank M.] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA. [Cadieux, C. Linn; Kasten, Shane A.; Reeves, Tony E.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Raushel, FM (reprint author), Texas A&M Univ, Dept Chem, POB 30012, College Stn, TX 77842 USA. EM raushel@tamu.edu RI Raushel, Frank/B-7125-2015 OI Raushel, Frank/0000-0002-5918-3089 FU National Institutes of Health [GM 68550] FX This work was supported by National Institutes of Health Grant GM 68550. NR 22 TC 40 Z9 41 U1 0 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD SEP 21 PY 2010 VL 49 IS 37 BP 7978 EP 7987 DI 10.1021/bi101056m PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 648RB UT WOS:000281710500004 PM 20701311 ER PT J AU Petrus, P Lisal, M Brennan, JK AF Petrus, Paval Lisal, Martin Brennan, John K. TI Self-Assembly of Lamellar- and Cylinder-Forming Diblock Copolymers in Planar Slits: Insight from Dissipative Particle Dynamics Simulations SO LANGMUIR LA English DT Article ID MONTE-CARLO SIMULATIONS; BLOCK-COPOLYMER; THIN-FILMS; MICROPHASE SEPARATION; STATISTICAL-MECHANICS; PHASE-EQUILIBRIA; MORPHOLOGY; CONFINEMENT; SYSTEMS; MELTS AB We present a dissipative pat tide dynamics simulation study on nanostructure formation of symmetric and asymmetric diblock copolymers confined between planar surfaces We consider symmetric and slightly asymmetric diblock copolymers that form lamellar nanostructures in the bulk, and highly asymmetric diblock copolymers that form cylindrical nanostructures in the bulk The formation of the diblock copolymer nanostructures confined between the planar surfaces is investigated and characterized by varying the separation width and the strength of the interaction between the surfaces and the diblock copolymers Both the slit width and the sui face Interaction strongly influence the phase diagram, especially for the asymmetric systems For the symmetric and slightly asymmetric diblock copolymer systems, the confinement primarily affects the orientation of the lamellar domains and only marginally influences the domain morphologies These systems form parallel lamellar phases with different number of lamellae, and perpendicular and mixed lamellar phases In a narrow portion of the phase diagram, these systems exhibit a parallel perforated lamellar phase, where further insight into the appearance of this phase is provided through free-energy calculations. The confined highly asymmetric diblock copolymer system shows, in addition to nanostructures with parallel and perpendicular cylinders, noncylindrical structures such as parallel lamellae and parallel perforated lamellae. The formation of the various confined nanostructures is further analyzed by calculating structural characteristics such as the mean glum e end-to-end distance of the diblock copolymers and the nematic order parameter C1 [Lisal, Martin] Acad Sci Czech Republic, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, VVI, CR-16502 Prague 6, Suchdol, Czech Republic. [Brennan, John K.] USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RI Lisal, Martin/A-8176-2011 OI Lisal, Martin/0000-0001-8005-7143 FU Grant Agency of the Czech Republic [203/08/0094)]; Academy of Sciences of the Czech Republic [KAN400720701]; Internal Grant Agency of the J E Purkinje University [53224 15 0008 01, 53222 15 0006 01]; European Community [TD0802/0C10053]; Army Research Laboratory [W911NF-10-2-0039] FX The authors are grateful to Alexandi Malijevsky (Institute of Chemical Process Fundamentals of the ASCR, v v i) for insightful discussions This research was supported by the Grant Agency of the Czech Republic (Grant 203/08/0094), by the Grant Programme of the Academy of Sciences of the Czech Republic "Nanotechnology for Society" (Project No KAN400720701), by the Internal Grant Agency of the J E Purkinje University (Grants 53224 15 0008 01 and No 53222 15 0006 01), and by the European Community under the seventh Framework Programme (Project COST TD0802/0C10053) This research was also sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0039 The views and conclusions contained in this document ale those of the authors and should not be interpreted as representing the official policies. either expressed or implied, of the Army Research Laboratory or the U S Government. NR 45 TC 24 Z9 26 U1 2 U2 35 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD SEP 21 PY 2010 VL 26 IS 18 BP 14680 EP 14693 DI 10.1021/la102666g PG 14 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 648JV UT WOS:000281690600045 PM 20795714 ER PT J AU Davis, R Rice, R Ballato, A Hawkins, T Foy, P Ballato, J AF Davis, R. Rice, R. Ballato, A. Hawkins, T. Foy, P. Ballato, J. TI Toward a photoconducting semiconductor RF optical fiber antenna array SO APPLIED OPTICS LA English DT Article ID TERAHERTZ RADIATION; TRANSMISSION-LINES; ELECTRICAL PULSES; GENERATION; SURFACES; SILICON AB Recently, optical fibers comprising a crystalline semiconductor core in a silica cladding have been successfully drawn by a conventional drawing process. These fibers are expected to exhibit a photoconductive response when illuminated by photons more energetic than the band gap of the core. In the photoconducting state, such a fiber can be expected to support driven RF currents so as to function as an antenna element, much as a plasma antenna. In this paper, we report the first device-related results on a crystalline semiconductor core optical fiber potentially useful in a photoconducting optical fiber antenna array; namely, optically induced changes to the electrical conductivity of a glass-clad germanium-core optical fiber. Since DC photoconduction measurements were masked by a photovoltaic effect, RF measurements at 5 MHz were used to determine the magnitude of the induced photoconductive effect. The observed photoconductivity, though not large in the present experiment, was comparable to that measured for the bulk crystals from which the fibers were drawn. The absorbed pumping light generated photo-carriers, thereby transforming the core from a dielectric material to a conductor. This technology could thus enable a class of transient antenna elements useful in low observable and reconfigurable antenna array applications. (c) 2010 Optical Society of America OCIS codes: 160.2290, 160.6000, 060.2290, 060.2310, 160.5140, 260.5150. C1 [Hawkins, T.; Foy, P.; Ballato, J.] Clemson Univ, COMSET, Clemson, SC 29625 USA. [Hawkins, T.; Foy, P.; Ballato, J.] Clemson Univ, Sch Mat Sci & Engn, Clemson, SC 29625 USA. [Hawkins, T.; Foy, P.; Ballato, J.] Clemson Univ, Holcombe Dept Elect & Comp Engn, Clemson, SC 29625 USA. [Davis, R.; Rice, R.] Northrop Grumman Aerosp Syst, Redondo Beach, CA 90278 USA. [Ballato, A.] USA, Commun Elect RDEC, RDE Command, Ft Monmouth, NJ 07703 USA. RP Ballato, J (reprint author), Clemson Univ, COMSET, Clemson, SC 29625 USA. EM jballat@clemson.edu FU Defense Advanced Research Projects Agency (DARPA) [HR0011-08-C-0137]; Northrop Grumman Corporation FX The authors wish to acknowledge financial support from the Defense Advanced Research Projects Agency (DARPA) under contract HR0011-08-C-0137, and the Northrop Grumman Corporation. The authors would like to thank Derek Tournear, Jerry Belyea, and Sheldon Meth for useful discussions. NR 37 TC 4 Z9 4 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD SEP 20 PY 2010 VL 49 IS 27 BP 5163 EP 5168 DI 10.1364/AO.49.005163 PG 6 WC Optics SC Optics GA 652KC UT WOS:000282004300020 PM 20856292 ER PT J AU Singh, J Im, J Whitten, JE Soares, JW Steeves, DM AF Singh, Jagdeep Im, Jisun Whitten, James E. Soares, Jason W. Steeves, Diane M. TI Chemisorption of a thiol-functionalized ruthenium dye on zinc oxide nanoparticles: Implications for dye-sensitized solar cells SO CHEMICAL PHYSICS LETTERS LA English DT Article ID PHOTOELECTRON-SPECTROSCOPY; PHOTOVOLTAIC APPLICATIONS; ZNO NANOPARTICLES; ENERGY-CONVERSION; METAL-OXIDES; TIO2 FILMS; COMPLEXES; ADSORPTION; LIGANDS; XPS AB ZnO is an alternative to TiO(2)-based dye-sensitized solar cells (DSSCs). Adsorption of cis-rutheniumbis[ 2,2 '- bipyridine]-bis[4-thiopyridine] onto ZnO nanorods has been studied using X-ray and ultraviolet photoelectron spectroscopies (XPS and UPS). XPS indicates chemisorption with a surface density of ca. 1 x 10(15) molecules/cm(2), confirming the possibility of using thiol-terminated dyes for ZnO-based DSSC devices. The energy level diagram, based on UPS and absorbance spectroscopy, indicates that the LUMO of this dye is lower in energy than the ZnO conduction band edge, providing minimal enthalpic driving force for photovoltaic electron injection. However, optimization of thiol-functionalized Ru dyes could result in competitive ZnO-based DSSCs. (c) 2010 Elsevier B.V. All rights reserved. C1 [Singh, Jagdeep; Im, Jisun; Whitten, James E.] Univ Massachusetts Lowell, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. [Singh, Jagdeep; Im, Jisun; Whitten, James E.] Univ Massachusetts Lowell, Ctr High Rate Nanomfg, Lowell, MA 01854 USA. [Soares, Jason W.; Steeves, Diane M.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Whitten, JE (reprint author), Univ Massachusetts Lowell, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. EM James_Whitten@uml.edu; diane.steeves@us.army.mil FU US Army Natick Soldier Research, Development and Engineering Center [W911NF-07-D-0001-0335 TCN 08047]; Tripathy Summer Fellowship FX This work was supported by the US Army Natick Soldier Research, Development and Engineering Center under Contract #W911NF-07-D-0001-0335 TCN 08047. Jagdeep Singh acknowledges a Tripathy Summer Fellowship. This document has been approved for unlimited distribution (PAO #U09-505). NR 39 TC 10 Z9 10 U1 2 U2 29 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD SEP 20 PY 2010 VL 497 IS 4-6 BP 196 EP 199 DI 10.1016/j.cplett.2010.08.009 PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 648YX UT WOS:000281732600010 ER PT J AU Nalca, A Livingston, VA Garza, NL Zumbrun, EE Frick, OM Chapman, JL Hartings, JM AF Nalca, Aysegul Livingston, Virginia A. Garza, Nicole L. Zumbrun, Elizabeth E. Frick, Ondraya M. Chapman, Jennifer L. Hartings, Justin M. TI Experimental Infection of Cynomolgus Macaques (Macaca fascicularis) with Aerosolized Monkeypox Virus SO PLOS ONE LA English DT Article ID VACCINIA VIRUS; SMALLPOX VACCINE; MODEL; PROTECTION; CHALLENGE; DISEASE; ST-246; CONGO AB Monkeypox virus (MPXV) infection in humans results in clinical symptoms very similar to ordinary smallpox. Aerosol is a route of secondary transmission for monkeypox, and a primary route of smallpox transmission in humans. Therefore, an animal model for aerosol exposure to MPXV is needed to test medical countermeasures. To characterize the pathogenesis in cynomolgus macaques (Macaca fascicularis), groups of macaques were exposed to four different doses of aerosolized MPXV. Blood was collected the day before, and every other day after exposure and assessed for complete blood count (CBC), clinical chemistry analysis, and quantitative PCR. Macaques showed mild anorexia, depression, and fever on day 6 post-exposure. Lymphadenopathy, which differentiates monkeypox from smallpox, was observed in exposed macaques around day 6 post-exposure. CBC and clinical chemistries showed abnormalities similar to human monkeypox cases. Whole blood and throat swab viral loads peaked around day 10, and in survivors, gradually decreased until day 28 post-exposure. Survival was not dose dependent. As such, doses of 4 x 10(4) PFU, 1 x 10(5) PFU, or 1 x 10(6) PFU resulted in lethality for 70% of the animals, whereas a dose of 4 x 10(5) PFU resulted in 85% lethality. Overall, cynomolgus macaques exposed to aerosolized MPXV develop a clinical disease that resembles that of human monkeypox. These findings provide a strong foundation for the use of aerosolized MPXV exposure of cynomolgus macaques as an animal model to test medical countermeasures against orthopoxviruses. C1 [Nalca, Aysegul; Livingston, Virginia A.; Garza, Nicole L.; Zumbrun, Elizabeth E.; Frick, Ondraya M.; Hartings, Justin M.] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. [Chapman, Jennifer L.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Nalca, A (reprint author), USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. EM aysegul.nalca@us.army.mil OI Zumbrun, Elizabeth/0000-0002-9897-7201 FU Office of Biodefense Research Affairs (OBRA)/National Institute of Allergy and Infectious Diseases (NIAID) [A120-B11]; USAMRIID FX This study was supported by an interagency agreement (IAA: A120-B11) between The Office of Biodefense Research Affairs (OBRA)/National Institute of Allergy and Infectious Diseases (NIAID) and USAMRIID. The sponsors had input in study design and review of the manuscript, but had no role in data collection and analysis, decision to publish, or preparation of the manuscript. NR 38 TC 19 Z9 19 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 20 PY 2010 VL 5 IS 9 AR e12880 DI 10.1371/journal.pone.0012880 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 651YH UT WOS:000281963200023 ER PT J AU Gastaldelli, A Harrison, S Belfort-Aguiar, R Hardies, J Balas, B Schenker, S Cusi, K AF Gastaldelli, A. Harrison, S. Belfort-Aguiar, R. Hardies, J. Balas, B. Schenker, S. Cusi, K. TI Pioglitazone in the treatment of NASH: the role of adiponectin SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS LA English DT Article ID HEPATIC INSULIN-RESISTANCE; ACTIVATED PROTEIN-KINASE; PLACEBO-CONTROLLED TRIAL; FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; DIABETES-MELLITUS; FIBROSIS; GLUCOSE; MICE; METABOLISM AB P>Background Plasma adiponectin is decreased in NASH patients and the mechanism(s) for histological improvement during thiazolidinedione treatment remain(s) poorly understood. Aim To evaluate the relationship between changes in plasma adiponectin following pioglitazone treatment and metabolic/histological improvement. Methods We measured in 47 NASH patients and 20 controls: (i) fasting glucose, insulin, FFA and adiponectin concentrations; (ii) hepatic fat content by magnetic resonance spectroscopy; and (iii) peripheral/hepatic insulin sensitivity (by double-tracer oral glucose tolerance test). Patients were then treated with pioglitazone (45 mg/day) or placebo and all measurements were repeated after 6 months. Results Patients with NASH had decreased plasma adiponectin levels independent of the presence of obesity. Pioglitazone increased 2.3-fold plasma adiponectin and improved insulin resistance, glucose tolerance and glucose clearance, steatosis and necroinflammation (all P < 0.01-0.001 vs. placebo). In the pioglitazone group, plasma adiponectin was significantly associated (r = 0.52, P = 0.0001) with hepatic insulin sensitivity and with the change in both variables (r = 0.44, P = 0.03). Increase in adiponectin concentration was related also to histological improvement, in particular, to hepatic steatosis (r = -0.46, P = 0006) and necroinflammation (r = -0.56, P < 0.0001) but importantly also to fibrosis (r = -0.29, P = 0.03). Conclusions Adiponectin exerts an important metabolic role at the level of the liver, and its increase during pioglitazone treatment is critical to reverse insulin resistance and improve liver histology in NASH patients. C1 [Gastaldelli, A.; Belfort-Aguiar, R.; Balas, B.; Cusi, K.] Univ Texas Hlth Sci Ctr San Antonio, Div Diabet, San Antonio, TX 78284 USA. [Gastaldelli, A.] CNR, Natl Res Council, Inst Clin Physiol, I-00185 Rome, Italy. [Harrison, S.] Brooke Army Med Ctr, Div Gastroenterol, San Antonio, TX USA. [Hardies, J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med & Radiol, San Antonio, TX 78284 USA. [Schenker, S.] Univ Texas Hlth Sci Ctr San Antonio, Div Gastroenterol, San Antonio, TX 78284 USA. [Cusi, K.] Brooke Army Med Ctr, Div Diabet, Audie L Murphy Vet Adm Med Ctr, San Antonio, TX USA. RP Cusi, K (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Div Diabet, Room 3-380S,7703 Floyd Curl Dr, San Antonio, TX 78284 USA. EM cusi@uthscsa.edu RI Hardies, Lou /F-2102-2010; Gastaldelli, Amalia/H-3319-2014 OI Gastaldelli, Amalia/0000-0003-2594-1651 FU Veterans Affairs Medical Research Fund; National Center for Research Resources [UL 1RR025767]; Italian National Research Council; Takeda Pharmaceuticals FX The authors thank the study volunteers, the nursing staff, and the nutrition and laboratory staff for their assistance in performing the described studies. Declaration of personal interests: Gastaldelli A, Harrison S, Belfort R, Hardies J, Balas B, Schenker S and Cusi K have no conflicts of interest. Declaration of funding interests: The project described (and Cusi K) was supported by the Veterans Affairs Medical Research Fund and by Award Number UL 1RR025767 from the National Center for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources of the National Institutes of Health. A. G. was supported by the Italian National Research Council. Partial support was received for the original study from Takeda Pharmaceuticals. NR 29 TC 46 Z9 51 U1 1 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-2813 J9 ALIMENT PHARM THER JI Aliment. Pharmacol. Ther. PD SEP 15 PY 2010 VL 32 IS 6 BP 769 EP 775 DI 10.1111/j.1365-2036.2010.04405.x PG 7 WC Gastroenterology & Hepatology; Pharmacology & Pharmacy SC Gastroenterology & Hepatology; Pharmacology & Pharmacy GA 639JX UT WOS:000280972200007 PM 20662773 ER PT J AU Klein, RJ Celina, MC Lenhart, JL AF Klein, Robert J. Celina, Mathew C. Lenhart, Joseph L. TI Porous Epoxies by Reaction Induced Phase Separation of Removable Alcohols: Control of Spheroidal Pore Size by Mass Fraction, Cure Temperature, and Reaction Rate SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE phase separation; reactive processing; sensors; reaction induced phase separation; porous; polymer; epoxy ID POLYMERS; BLENDS; SCAFFOLDS; KINETICS; HYDROGEN; BEHAVIOR AB Porous organic and inorganic materials with both random and controlled microstructures have utility in a variety of fields including catalysis, sensors, separations, optical platforms, tissue engineering, hydrogen storage, micro-electronics, medical diagnostics, as well as other applications. This work highlights a simple and general technique for tuning the pore size in crosslinking polymeric systems by adding a solvent poragen that phase separates during the curing process (reaction induced phase separation). The pore size can be controlled over large length scales ranging from microns to well below 100 nanometers. In this system an amine cured epoxy resin was reacted in the presence of the sacrificial poragen octadecanol, which is removed by vacuum-assisted evaporation once the epoxy components have reacted to form a solid, porous matrix. The importance of the present approach is based on the simplicity of the chemical formulation, the ease by which other epoxide or amine chemistries may be substituted for the two reactive components, and the control of pore size down to the nanometer scale by the addition of a small amount of catalyst. (C) 2010 Wiley Periodicals, Inc.(dagger) J Appl Polym Sci 117: 3300-3307, 2010 C1 [Klein, Robert J.; Celina, Mathew C.; Lenhart, Joseph L.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Lenhart, Joseph L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Klein, RJ (reprint author), Luna Innovat Inc, 706 Forest St,Suite A, Charlottesville, VA 22903 USA. EM kleinr@lunainnovations.com; joseph.lenhart1@arl.army.mil FU United States Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX The authors thank Bonnie McKenzie at Sandia National Laboratories for excellent SEM images. The bulk of this work was completed at Sandia National Laboratories, and further research is progressing at the U.S. Army Research Laboratory by ILL. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Certain commercial equipment and materials are identified in this article to specify adequately the experimental procedure. In no case does such identification imply recommendations by the Army Research Laboratory nor does it imply that the material or equipment identified is necessarily the best available for this purpose. NR 38 TC 0 Z9 0 U1 2 U2 13 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD SEP 15 PY 2010 VL 117 IS 6 BP 3300 EP 3307 DI 10.1002/app.30702 PG 8 WC Polymer Science SC Polymer Science GA 626HY UT WOS:000279958200025 ER PT J AU Walton, SG Lock, EH Ni, A Baraket, M Fernsler, RF Pappas, DD Strawhecker, KE Bujanda, AA AF Walton, S. G. Lock, E. H. Ni, A. Baraket, M. Fernsler, R. F. Pappas, D. D. Strawhecker, K. E. Bujanda, A. A. TI Study of Plasma-Polyethylene Interactions Using Electron Beam-Generated Plasmas Produced in Ar/SF6 Mixtures SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE aging; functionalization of polymers; fluorination; polyethylene; cold plasma ID GLOW-DISCHARGE PLASMA; SURFACE FLUORINATION; POLYMERS; FILMS; POLYSTYRENE; COMPOSITES; ADHESION; FIBERS; ENERGY AB The use of electron beam-generated plasmas produced in Ar/SF6 mixtures to modify the surface of ultra-high molecular weight polyethylene substrates is discussed. Changes in the surface energy, chemistry, and morphology are presented as a function of plasma operating parameters, along with simple system diagnostics to obtain a better understanding of the plasma-polymer interaction. For all conditions, the hydrophobicity of the material was increased via the incorporation of fluorine, and for some conditions, the surface was found to remain stable over the course of 1 year. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 117: 3515-3523, 2010 C1 [Walton, S. G.; Lock, E. H.; Ni, A.; Baraket, M.; Fernsler, R. F.] USN, Res Lab, Div Plasma Phys, Washington, DC 20375 USA. [Ni, A.; Baraket, M.] Global Strategies Inc, Crofton, MD 21114 USA. [Pappas, D. D.; Strawhecker, K. E.; Bujanda, A. A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Walton, SG (reprint author), USN, Res Lab, Div Plasma Phys, Washington, DC 20375 USA. EM scott.walton@nrl.navy.mil FU Office of Naval Research; National Research Council; Army Research Laboratory FX Contract grant sponsor: Office of Naval Research and the Army Research Laboratory and National Research Council. NR 34 TC 13 Z9 13 U1 0 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD SEP 15 PY 2010 VL 117 IS 6 BP 3515 EP 3523 DI 10.1002/app.32249 PG 9 WC Polymer Science SC Polymer Science GA 626HY UT WOS:000279958200052 ER PT J AU Kirchner, KW Derenge, MA Zheleva, TS Vispute, RD Jones, KA AF Kirchner, K. W. Derenge, M. A. Zheleva, T. S. Vispute, R. D. Jones, K. A. TI Growth of GaN films on PLD-deposited TaC substrates SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Lattice match; Gallium aluminum nitride; Silicon carbide; Tantalum carbide ID MOLECULAR-BEAM EPITAXY; MOCVD GROWTH; CARBIDE AB GaN films were grown by metal organic chemical vapor deposition on TaC substrates that were created by pulsed laser deposition of TaC onto (0 0 0 1) SiC substrates at similar to 1000 degrees C. This was done to determine if good quality TaC films could be grown, and if good quality GaN films could be grown on this closely lattice matched to GaN, conductive material. This was done by depositing the TaC on on-axis and 3 degrees or 8 degrees off-axis (0 0 0 1) SiC at temperatures ranging from 950 to 1200 degrees C, and examining them using X-ray diffraction, scanning electron microscopy, atomic force microscopy, and transmission electron microscopy. The GaN films were grown on as-deposited TaC films, and films annealed at 1200, 1400, or 1600 degrees C, and examined using the same techniques. The TaC films were polycrystalline with a slight (1 1 1) texture, and the grains were similar to 200 nm in diameter. Films grown on-axis were found to be of higher quality than those grown on off-axis substrates, but the latter could be improved to a comparable quality by annealing them at 1200-1600 degrees C for 30 min. TaC films deposited at temperatures above 1000 degrees C were found to react with the SiC. GaN films could be deposited onto the TaC when the surface was nitrided with NH(3) for 3 min at 1100 degrees C and the low temperature buffer layer was AlN. However, the GaN did not nucleate easily on the TaC film, and the crystallites did not have the desired (0 0 0 1) preferred orientation. They were similar to 10 times larger than those typically seen in films grown on SiC or sapphire. Also the etch pit concentration in the GaN films grown on the TaC was more than 2 orders of magnitude less than it was for growth on the SiC. Published by Elsevier B.V. C1 [Kirchner, K. W.; Derenge, M. A.; Zheleva, T. S.; Jones, K. A.] Army Res Lab, Adelphi, MD 20783 USA. [Vispute, R. D.] Univ Maryland, Ctr Nanophys & Adv Mat, College Pk, MD 20742 USA. RP Jones, KA (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM kajones@arl.army.mil NR 20 TC 0 Z9 1 U1 1 U2 27 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD SEP 15 PY 2010 VL 312 IS 19 BP 2661 EP 2670 DI 10.1016/j.jcrysgro.2010.06.010 PG 10 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 656PU UT WOS:000282349500006 ER PT J AU Wang, D Svensson, SP Shterengas, L Belenky, G AF Wang, D. Svensson, S. P. Shterengas, L. Belenky, G. TI Near band edge optical absorption and photoluminescence dynamics in bulk InAsN dilute-nitride materials SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Ultra fast; Carrier lifetime; Absorption; Photoluminescence; InAsN; Dilute-nitride ID ALLOYS; LASERS; GAAS AB Dilute-nitride InAs bulk materials with up to 2.25% of nitrogen were grown by molecular beam epitaxy on InAs substrates. Photoluminescence (PL) and optical absorption measurements demonstrate a bandgap reduction by up to 150 meV with increasing nitrogen incorporation. Close correspondence of the energies of the photoluminescence peak and absorption edges indicate limited Moss-Burstein shift. Minority carrier lifetimes in the nanosecond range are measured using an ultra-fast PL up-conversion technique for the samples with up to 2% of nitrogen. Orders of magnitude advance of the carrier relaxation lifetimes as compared to GaSbN encourage development of the InAsN as a potential material for mid-IR detector applications. (C) 2010 Elsevier B.V. All rights reserved. C1 [Wang, D.; Shterengas, L.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. [Svensson, S. P.] Army Res Lab, Adelphi, MD 20783 USA. RP Wang, D (reprint author), SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. EM dwang@ece.sunysb.edu FU National Science Foundation [DMR071054]; Missile Defense Agency [W911NF0720086] FX This work was supported by the National Science Foundation under Grant DMR071054 and the Missile Defense Agency under contract W911NF0720086. NR 15 TC 4 Z9 4 U1 0 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD SEP 15 PY 2010 VL 312 IS 19 BP 2705 EP 2709 DI 10.1016/j.jcrysgro.2010.06.007 PG 5 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 656PU UT WOS:000282349500013 ER PT J AU Boddu, VM Viswanath, DS Ghosh, TK Damavarapu, R AF Boddu, Veera M. Viswanath, Dabir S. Ghosh, Tushar K. Damavarapu, R. TI 2,4,6-Triamino-1,3,5-trinitrobenzene (TATB) and TATB-based formulations-A review SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Review DE TATB; Synthesis; Structure; Physical and thermodynamic properties; Formulations; Review ID HIGH-ENERGY MATERIALS; X-RAY-SCATTERING; 1,3,5-TRIAMINO-2,4,6-TRINITROBENZENE TATB; PHYSICOCHEMICAL PROPERTIES; RECRYSTALLIZATION; EXPLOSIVES; GENERATION; CRYSTAL; INITIO; HEATS AB This paper reviews the research and development work on 2,4,6-triamino-1,3,5-trinitrobenzene (TATB), and TATB-based formulations of other explosives. Syntheses including the production of nano-sized particles, analytical methods, thermophysical properties, performance, formulations, toxicity and safety of TATB are reviewed in this work. (C) 2010 Elsevier B.V. All rights reserved. C1 [Viswanath, Dabir S.; Ghosh, Tushar K.] Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. [Boddu, Veera M.] USA, Corps Engineers, Environm Proc Branch, Engn Res & Dev Ctr,Construct Engn Res Lab, Champaign, IL 61826 USA. [Damavarapu, R.] USA, Armaments Res, Energet Mat Div, Picatinny Arsenal, NJ 07806 USA. RP Viswanath, DS (reprint author), Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. EM viswanathd@missouri.edu NR 60 TC 34 Z9 41 U1 5 U2 36 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD SEP 15 PY 2010 VL 181 IS 1-3 BP 1 EP 8 DI 10.1016/j.jhazmat.2010.04.120 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 634RM UT WOS:000280601300001 PM 20554109 ER PT J AU Alvarez-Guerra, M Canis, L Voulvoulis, N Viguri, JR Linkov, I AF Alvarez-Guerra, Manuel Canis, Laure Voulvoulis, Nikolaos Viguri, Javier R. Linkov, Igor TI Prioritization of sediment management alternatives using stochastic multicriteria acceptability analysis SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Sediment; Management; Multicriteria decision analysis; Stochastic multicriteria acceptability analysis ID COMPARATIVE RISK-ASSESSMENT; MULTIATTRIBUTE UTILITY MEASUREMENT; DREDGED MATERIAL MANAGEMENT; DECISION-ANALYSIS APPROACH; YORK/NEW-JERSEY HARBOR; CONTAMINATED SEDIMENTS; SOUTH-KOREA; FRAMEWORK; CRITERIA; REMEDIATION AB Decision-making for sediment management is a complex task that requires the consideration of temporal and spatial impacts of several remedial alternatives as well as the associated economic, social and political impact. Multicriteria decision analysis (MCDA) is becoming increasingly recognized as an important environmental management tool that can be used to support the selection of suitable remediation alternatives and prioritization of management units in space and time. This paper proposes an MCDA framework for prioritizing sediment management alternatives. This framework involves identifying of a set of feasible options, as well as defining and evaluating criteria which integrate relevant technical, economic, social and environmental aspects of remedies. The methodology allows an explicit consideration of uncertainty in criteria scores and weights by assigning probability distributions and analyzing subsequent Monte-Carlo simulations. The consideration of different stakeholder simulated values is used to assess the robustness of alternative rankings and to guide the selection of remediation options. An application of this methodology to a case study in the Bay of Santander, Spain, is presented. An assessment is conducted for the case of unknown preferences as well as for hypothetical preferences profiles for four types of stakeholders: Idealist, Politician, Environmentalist and Balanced. The results are used to visualize stakeholder positions and potential disagreements, allowing for the identification of a group of least preferred alternatives for each stakeholder. Stakeholder involvement has the potential to ease the remedy selection process during all stages of the decision-making process and to eventually remedy implementation. Published by Elsevier B.V. C1 [Canis, Laure; Linkov, Igor] USA, Engn Res & Dev Ctr, Concord, MA 01742 USA. [Alvarez-Guerra, Manuel; Viguri, Javier R.] Univ Cantabria, ETSIIT, Dept Chem Engn & Inorgan Chem, E-39005 Santander, Spain. [Voulvoulis, Nikolaos] Univ London Imperial Coll Sci Technol & Med, Ctr Environm Policy, London SW7 2AZ, England. RP Linkov, I (reprint author), USA, Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil RI Voulvoulis, Nikolaos/C-9246-2012; Alvarez-Guerra, Manuel/A-7734-2010; Viguri, Javier/K-4011-2014 OI Voulvoulis, Nikolaos/0000-0001-9703-3703; Alvarez-Guerra, Manuel/0000-0002-3546-584X; Viguri, Javier/0000-0002-6658-0429 FU Spanish Ministry of Science and Innovation [CTM 2008-06344-C03-01]; US Army Corps of Engineers' Dredging Operations and Environmental Research (DOER) FX We would like to thank Drs. Christy Foran and Jeff Keisler for review and discussions and Kun Zan, Benjamin Trump, and Eric Chu for editorial assistance. This research project was supported in part by the financial help of the Spanish Ministry of Science and Innovation Project CTM 2008-06344-C03-01. Manuel Alvarez-Guerra was funded by the Spanish Ministry of Science and Innovation by means of an F.P. U. fellowship. Additional funding was provided by the US Army Corps of Engineers' Dredging Operations and Environmental Research (DOER) Program. Permission was granted by the USACE Chief of Engineers to publish this material. NR 74 TC 15 Z9 17 U1 0 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD SEP 15 PY 2010 VL 408 IS 20 BP 4354 EP 4367 DI 10.1016/j.scitotenv.2010.07.016 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA 651MJ UT WOS:000281931500010 PM 20673964 ER PT J AU Rimoin, AW Mulembakani, PM Johnston, SC Lloyd-Smith, JO Kisalu, NK Kinkela, TL Blumberg, S Thomassen, HA Pike, BL Fair, JN Wolfe, ND Shongo, RL Graham, BS Formenty, P Okitolonda, E Hensley, LE Meyer, H Wright, LL Muyembe, JJ AF Rimoin, Anne W. Mulembakani, Prime M. Johnston, Sara C. Lloyd-Smith, James O. Kisalu, Neville K. Kinkela, Timothee L. Blumberg, Seth Thomassen, Henri A. Pike, Brian L. Fair, Joseph N. Wolfe, Nathan D. Shongo, Robert L. Graham, Barney S. Formenty, Pierre Okitolonda, Emile Hensley, Lisa E. Meyer, Hermann Wright, Linda L. Muyembe, Jean-Jacques TI Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE active surveillance; orthopoxvirus; zoonosis; eradication ID ROCHE LIGHTCYCLER; VIRUS DETECTION; PRAIRIE DOGS; WEST-AFRICA; TRANSMISSION; ZAIRE; INDIVIDUALS; INFECTION; EFFICACY; ASSAYS AB Studies on the burden of human monkeypox in the Democratic Republic of the Congo (DRC) were last conducted from 1981 to 1986. Since then, the population that is immunologically naive to orthopoxviruses has increased significantly dueto cessation of mass smallpox vaccination campaigns. To assess the current risk of infection, we analyzed human monkeypox incidence trends in a monkeypox-enzootic region. Active, population-based surveillance was conducted in nine health zones in central DRC. Epidemiologic data and biological samples were obtained from suspected cases. Cumulative incidence (per 10,000 population) and major determinants of infection were compared with data from active surveillance in similar regions from 1981 to 1986. Between November 2005 and November 2007, 760 laboratory-confirmed human monkeypox cases were identified in participating health zones. The average annual cumulative incidence across zones was 5.53 per 10,000 (2.18-14.42). Factors associated with increased risk of infection included: living in forested areas, male gender, age < 15, and no prior smallpox vaccination. Vaccinated persons had a 5.2-fold lower risk of monkeypox than unvaccinated persons (0.78 vs. 4.05 per 10,000). Comparison of active surveillance data in the same health zone from the 1980s (0.72 per 10,000) and 2006-07 (14.42 per 10,000) suggests a 20-fold increase in human monkeypox incidence. Thirty years after mass smallpox vaccination campaigns ceased, human monkeypox incidence has dramatically increased in rural DRC. Improved surveillance and epidemiological analysis is needed to better assess the public health burden and develop strategies for reducing the risk of wider spread of infection. C1 [Rimoin, Anne W.] Univ Calif Los Angeles, Los Angeles Sch Publ Hlth, Los Angeles, CA 90095 USA. [Rimoin, Anne W.; Lloyd-Smith, James O.; Blumberg, Seth] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Mulembakani, Prime M.; Kinkela, Timothee L.; Okitolonda, Emile] Kinshasa Sch Publ Hlth, Kinshasa, Zaire. [Johnston, Sara C.; Hensley, Lisa E.] USA, Res Inst Infect Dis, Frederick, MD 21702 USA. [Lloyd-Smith, James O.; Blumberg, Seth] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90095 USA. [Kisalu, Neville K.] Univ Calif Los Angeles, Dept Microbiol, Los Angeles, CA 90095 USA. [Thomassen, Henri A.] Univ Calif Los Angeles, Ctr Trop Res, Inst Environm, Los Angeles, CA 90095 USA. [Pike, Brian L.; Fair, Joseph N.; Wolfe, Nathan D.] Global Viral Forecasting Initiat, San Francisco, CA 94105 USA. [Shongo, Robert L.] Minist Hlth, Kinshasa, Zaire. [Graham, Barney S.] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Formenty, Pierre] WHO, Dept Global Alert & Response, CH-1211 Geneva 27, Switzerland. [Meyer, Hermann] Bundeswehr Inst Microbiol, D-80937 Munich, Germany. [Wright, Linda L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD 20892 USA. [Muyembe, Jean-Jacques] Natl Inst Biomed Res, Kinshasa, Zaire. RP Rimoin, AW (reprint author), Univ Calif Los Angeles, Los Angeles Sch Publ Hlth, Los Angeles, CA 90095 USA. EM arimoin@ucla.edu RI Lloyd-Smith, James/K-4080-2012; Valle, Ruben/A-7512-2013 OI Lloyd-Smith, James/0000-0001-7941-502X; FU Eunice Kennedy Shriver National Institute of Child Health and Human Development; Global Network for Women's and Children's Health Research; National Institute of Allergy and Infectious Disease, Division of Infectious Diseases and Microbiology; National Institutes of Health Director's Office; Fogarty International Center; Skoll Foundation; Department of Homeland Security; Pacific Southwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease; Defense Threat Reduction Agency; Global Viral Forecasting Initiative; US Agency for International Development Emerging Pandemic Threats Program; Faucett Family Foundation FX Many individuals contributed to the design of this manuscript and data collection in the field. We thank the Congolese health workers in the Sankuru District for their surveillance efforts and the DRC Ministry of Health and World Health Organization Country office in Kinshasa. We also thank Drs. Joel G. Breman, Donald A. Henderson, Onyebuchi Arah, Roger Detels, Harout Armenian, and Robert W. Ryder for their comments and suggestions on the manuscript and Eric Wilkinson, Erick Mucker, Carly Wlazlowski, and Jay Goff for organizational and technical laboratory support. Funding for this work was provided by: the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Global Network for Women's and Children's Health Research; National Institute of Allergy and Infectious Disease, Division of Infectious Diseases and Microbiology; National Institutes of Health Director's Office [through a National Institutes of Health Director's Pioneer Award (N.D.W.)]; Fogarty International Center, Research and Policy for Infectious Disease Dynamics program of the Science and Technology Directorate, Department of Homeland Security; Pacific Southwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease; Defense Threat Reduction Agency; the Global Viral Forecasting Initiative (supported by Google.org, the Skoll Foundation, and the US Agency for International Development Emerging Pandemic Threats Program); and the Faucett Family Foundation. NR 33 TC 110 Z9 112 U1 1 U2 18 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD SEP 14 PY 2010 VL 107 IS 37 BP 16262 EP 16267 DI 10.1073/pnas.1005769107 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 649UI UT WOS:000281799000053 PM 20805472 ER PT J AU Youso, SL Rockwood, GA Lee, JP Logue, BA AF Youso, Stephanie L. Rockwood, Gary A. Lee, John P. Logue, Brian A. TI Determination of cyanide exposure by gas chromatography mass spectrometry analysis of cyanide-exposed plasma proteins SO ANALYTICA CHIMICA ACTA LA English DT Article DE Thiocyanate; Protein adducts; Biomarker; Gas chromatography-mass spectrometry; Extraction; Bioanalysis; Derivatization ID THIOCYANATE LEVELS; WARFARE AGENTS; BLOOD CYANIDE; POPULATION; ADDUCTS; SALIVA; URINE; SMOKE; SERUM AB Exposure to cyanide can occur in a variety of ways, including exposure to smoke from cigarettes or fires, accidental exposure during industrial processes, and exposure from the use of cyanide as a poison or chemical warfare agent. Confirmation of cyanide exposure is difficult because, in vivo, cyanide quickly breaks down by a number of pathways, including the formation of both free and protein-bound thiocyanate. A simple method was developed to confirm cyanide exposure by extraction of protein-bound thiocyanate moieties from cyanide-exposed plasma proteins. Thiocyanate was successfully extracted and subsequently derivatized with pentafluorobenzyl bromide for GC-MS analysis. Thiocyanate levels as low as 2.5 ng mL(-1) and cyanide exposure levels as low as 175 mu g kg(-1) were detected. Samples analyzed from smokers and non-smokers using this method showed significantly different levels of protein-bound thiocyanate (p<0.01). These results demonstrate the potential of this method to positively confirm chronic cyanide exposure through the analysis of protein-bound cyanide in human plasma. (C) 2010 Elsevier B.V. All rights reserved. C1 [Youso, Stephanie L.; Lee, John P.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Rockwood, Gary A.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, Shepard Hall 121,Box 2202, Brookings, SD 57007 USA. EM Brian.Logue@sdstate.edu FU US Army Medical Research Institute of Chemical Defense [DAAD19-02-D-0001]; NIH/USAMRICD [Y1-A1-6176-03/A120-B.P2008-01]; National Institutes of Health; Department of Defense FX A portion of this work was supported by the US Army Medical Research Institute of Chemical Defense under the auspices of the US Army Research Office Scientific Services Program administered by Battelle (Delivery Order 399, Contract No. DAAD19-02-D-0001) and by NIH/USAMRICD Interagency agreement Y1-A1-6176-03/A120-B.P2008-01. We gratefully acknowledge funding from the National Institutes of Health and the Department of Defense through the Cyanide Medical Countermeasures and the Medical Diagnostics research areas. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the National Institutes of Health, Department of the Army, or the Department of Defense. NR 26 TC 12 Z9 14 U1 3 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD SEP 10 PY 2010 VL 677 IS 1 SI SI BP 24 EP 28 DI 10.1016/j.aca.2010.01.028 PG 5 WC Chemistry, Analytical SC Chemistry GA 660DW UT WOS:000282620900004 PM 20850585 ER PT J AU Bloom, M Corriveau, J Giordano, P Lecakes, GD Mandayam, S Sukumaran, B AF Bloom, Michael Corriveau, Jonathan Giordano, Patrick, Jr. Lecakes, George D., Jr. Mandayam, Shreekanth Sukumaran, Beena TI Imaging Systems and Algorithms for the Numerical Characterization of Three-Dimensional Shapes of Granular Particles SO IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT LA English DT Article DE Image reconstruction; image shape analysis; imaging; optical tomography (OT); X-ray tomography ID ROCK PARTICLES; RECONSTRUCTION; MODEL AB The shear properties of natural granular particles such as sand are significantly dependent on the shapes of the particles in the mixture. This is important from a practical view-point, because a measurement and characterization technique for the 3-D shapes of such particles can lead to an improved understanding of soil stability and influence the design of structural foundations. Previous techniques that have been developed for this purpose have proven to be complex, and the associated instrumentation has proven to be expensive. Furthermore, conventional 2-D shape measurement and description methods do not readily lend themselves to parsimonious 3-D representations. The situation is further complicated by the fact that, to parameterize the relationship between shape and shear characteristics, a single numerical descriptor is required tomodel the 3-D shapes of multiple particles in a natural sand particle mixture. This paper describes an optical tomography technique for the measurement of particle data that is then characterized using statistical 3-D shape descriptors. The algebraic reconstruction technique (ART) is used to synthesize 3-D particle shapes from 2-D tomography projections. It is shown that the measurement and characterization techniques used can provide distinct features for differently shaped particle mixtures and can be used to synthesize 3-D composite particles representative of the entire mix. The novelty of the technique described in this paper is that numerical shape descriptors can be obtained for not only a single 3-D object but also an entire collection of 3-D objects. Furthermore, the statistical nature of the 3-D shape descriptor of a particle mixture can be used to synthesize a mixture containing an arbitrary number of particles that have similar but not identical shapes. Results demonstrating the efficacy of the method on a set of natural sand particle mixtures are presented. C1 [Bloom, Michael; Mandayam, Shreekanth] Rowan Univ, Dept Elect & Comp Engn, Glassboro, NJ 08028 USA. [Corriveau, Jonathan] USA, Radar Syst Branch, Ft Monmouth, NJ 07703 USA. [Giordano, Patrick, Jr.] Lockheed Martin Corp, Moorestown, NJ 08057 USA. [Lecakes, George D., Jr.] Drexel Univ, Philadelphia, PA 19104 USA. [Sukumaran, Beena] Rowan Univ, Dept Civil & Environm Engn, Glassboro, NJ 08028 USA. RP Bloom, M (reprint author), Rowan Univ, Dept Elect & Comp Engn, Glassboro, NJ 08028 USA. EM shreek@rowan.edu NR 24 TC 1 Z9 1 U1 1 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9456 J9 IEEE T INSTRUM MEAS JI IEEE Trans. Instrum. Meas. PD SEP 10 PY 2010 VL 59 IS 9 BP 2365 EP 2375 DI 10.1109/TIM.2009.2034579 PG 11 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 664KB UT WOS:000282957700011 ER PT J AU Tung, LC Folkes, PA Gumbs, G Xu, W Wang, YJ AF Tung, L. -C. Folkes, P. A. Gumbs, Godfrey Xu, W. Wang, Y. -J. TI Magneto-infrared modes in InAs-AlSb-GaSb coupled quantum wells SO PHYSICAL REVIEW B LA English DT Article ID ELECTRON-HOLE SYSTEM; BOSE-EINSTEIN CONDENSATION; CYCLOTRON-RESONANCE OSCILLATIONS; SPATIALLY SEPARATED ELECTRONS; EXCITON-POLARITON CONDENSATE; INAS/GASB HETEROSTRUCTURES; PHASE-TRANSITION; SUPER-LATTICES; GROUND-STATE; SEMICONDUCTOR MICROCAVITY AB We have studied a series of InAs/GaSb coupled quantum wells using magneto-infrared spectroscopy for high magnetic fields up to 33 T within temperatures ranging from 4 to 45 K in both Faraday and tilted field geometries. This type of coupled quantum wells consists of an electron layer in the InAs quantum well and a hole layer in the GaSb quantum well, forming the so-called two-dimensional electron-hole bilayer system. Unlike the samples studied in the past, the hybridization of the electron and hole subbands in our samples is largely reduced by having narrower wells and an AlSb barrier layer interposed between the InAs and the GaSb quantum wells, rendering them weakly hybridized. Previous studies have revealed multiple absorption modes near the electron cyclotron resonance of the InAs layer in moderately and strongly hybridized samples while only a single absorption mode was observed in the weakly hybridized samples. We have observed a pair of absorption modes occurring only at magnetic fields higher than 14 T, which exhibited several interesting phenomena. Among which we found two unique types of behavior that distinguish this work from the ones reported in the literature. This pair of modes is very robust against rising thermal excitations and increasing magnetic fields aligned parallel to the heterostructures. While the previous results were aptly explained by the antilevel crossing due to the hybridization of the electron and hole wave functions, i.e., conduction-valence Landau-level mixing, the unique features reported in this paper cannot be explained within the same concept. The unusual properties found in this study and their connection to the known models for InAs/GaSb heterostructures will be discussed; in addition, several alternative ideas will be proposed in this paper and it appears that a spontaneous phase separation can account for most of the observed features. C1 [Tung, L. -C.; Wang, Y. -J.] Natl High Magnet Lab, Tallahassee, FL 32310 USA. [Folkes, P. A.] USA, Res Lab, Adelphi, MD 20783 USA. [Gumbs, Godfrey] CUNY Hunter Coll, New York, NY 10021 USA. [Xu, W.] Chinese Acad Sci, Inst Solid State Phys, Hefei 23031, Peoples R China. [Xu, W.] Yunnan Univ, Kunming 650091, Peoples R China. RP Tung, LC (reprint author), Natl High Magnet Lab, Tallahassee, FL 32310 USA. FU AFRL [9453-07-C-0207]; National Science Foundation; State of Florida; Chinese Academy of Sciences; National Natural Science Foundation of China FX This research was supported by Contract No. 9453-07-C-0207 of AFRL. The measurement was performed at NHMFL at Tallahassee, supported by the National Science Foundation and the state of Florida. One of us (W.X.) was supported by the Chinese Academy of Sciences and National Natural Science Foundation of China. NR 118 TC 2 Z9 2 U1 1 U2 6 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD SEP 9 PY 2010 VL 82 IS 11 AR 115305 DI 10.1103/PhysRevB.82.115305 PG 13 WC Physics, Condensed Matter SC Physics GA 647ZC UT WOS:000281658400004 ER PT J AU Lee, SH Lillehoj, HS Jang, SI Lee, KW Yancey, R Dominowski, P AF Lee, Sung-Hyen Lillehoj, Hyun S. Jang, Seung I. Lee, Kyung-Woo Yancey, Roberti. Dominowski, Paul TI The effects of a novel adjuvant complex/Eimeria profilin vaccine on the intestinal host immune response against live E. acervulina challenge infection SO VACCINE LA English DT Article DE Adjuvant; Eimeria profilin; Coccidiosis; Immunity; Cytokine; Chicken ID DIOCTADECYL AMMONIUM BROMIDE; EIMERIA-TENELLA; BROILER-CHICKENS; GENE-EXPRESSION; FUNCTIONAL-CHARACTERIZATION; SALMONELLA-TYPHIMURIUM; ANTICOCCIDIAL VACCINES; PROTECTIVE IMMUNITY; SUBUNIT VACCINES; DNA VACCINATION AB The effects of a novel adjuvant composed of Quil A, cholesterol, dimethyl dioctadecyl ammonium bromide, and Carbopol (QCDC) on protective immunity against avian coccidiosis following immunization with an Eimeria recombinant protein were determined. Broiler chickens were subcutaneously immunized with isotonic saline (control), Eimeria recombinant profilin alone, or profilin emulsified with QCDC at 1 and 7 days post-hatch, and orally challenged with live Eimeria acervulina at 7 days following the last immunization. Body weight gains, gut lesion scores, fecal oocyst outputs, profilin serum antibody titers, lymphocyte proliferation, and intestinal cytokine transcript levels were assessed as measures of protective immunity. Chickens immunized with profilin plus QCDC showed increased body weight gains and decreased intestinal lesion scores compared with the profilin only or control groups. However, no differences were found in fecal oocyst shedding among the three groups. Profilin serum antibody titers and antigen-induced peripheral blood lymphocyte proliferation in the profilin/QCDC group were higher compared with the profilin only and control groups. Finally, while immunization with profilin alone or profilin plus QCDC uniformly increased the levels of intestinal transcripts encoding all cytokines examined (IL-1 beta, IL-10, IL-12, IL-15,IL-17F, and IFN-gamma) compared with the control group, transcripts for IL-10 and IL-17F were further increased in the profilin/QCDC group compared with the profilin only group. In summary, this study provides the first evidence of the immunoenhancing activities of QCDC adjuvant in poultry. Published by Elsevier Ltd. C1 [Lee, Sung-Hyen; Lillehoj, Hyun S.; Jang, Seung I.; Lee, Kyung-Woo] USA, Dept Agr, Anim Parasit Dis Lab, Anim & Nat Resources Inst,Agr Res Serv, Beltsville, MD 20705 USA. [Yancey, Roberti.; Dominowski, Paul] Pfizer Inc, Kalamazoo, MI 49007 USA. RP Lillehoj, HS (reprint author), USA, Dept Agr, Anim Parasit Dis Lab, Anim & Nat Resources Inst,Agr Res Serv, Beltsville, MD 20705 USA. EM Hyun.Lillehoj@ars.usda.gov OI Lee, Kyung-Woo/0000-0002-3533-7979 FU Agricultural Research Service Current Research Information System (ARS CRIS) [1265-32000-086] FX This project was partially supported by the Agricultural Research Service Current Research Information System (ARS CRIS) project 1265-32000-086 and a formal agreement established between ARS and Pfizer Animal Health. QCDC was supplied by the Pfizer Inc. (Kalamazoo, MI). The authors thank Margie Nichols and Stacy Torreyson for their significant contributions to this research. NR 68 TC 18 Z9 19 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 7 PY 2010 VL 28 IS 39 BP 6498 EP 6504 DI 10.1016/j.vaccine.2010.06.116 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 656ZE UT WOS:000282378900016 PM 20637765 ER PT J AU Luo, CY Chambers, C Yang, YR Saxena, A AF Luo, Chunyuan Chambers, Carolyn Yang, Yerie Saxena, Ashima TI Mechanism for potent reactivation ability of H oximes analyzed by reactivation kinetic studies with cholinesterases from different species SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Human acetylcholinesterase; Rhesus monkey acetylcholinesterase; Guinea pig acetylcholinesterase; Nerve agent; H oxime; Reactivation mechanism ID HUMAN ACETYLCHOLINESTERASES; ORGANOPHOSPHORUS COMPOUNDS; AQUEOUS-SOLUTION; DESIGN; SOMAN; TABUN; DECOMPOSITION; INHIBITION; COMPLEX; PIG AB Oxime-induced reactivation of organophosphorus (OP) nerve agent-inhibited acetylcholinesterase (AChE) is a very important step for the treatment of nerve agent toxicity. Therefore, extensive efforts are being made to develop more efficient and broad-spectrum oximes to replace the currently used oximes 2-PAM or obidoxime. In the 1970s and 1980s, several H oximes (such as HI-6 and HLo-7) were found to be very potent reactivators of non-aged soman-inhibited AChE. Later these oximes were shown to rapidly reactivate GF- and VR-inhibited AChE as well. However, the mechanism for the high potency of these H oximes is still unknown. In this study, the relationship between the reactivation rate constant of nerve agent-inhibited rhesus monkey AChE, human AChE and guinea pig AChE and the size of the alkoxyl (OR) group of nerve agents was analyzed. Results demonstrate that for nerve agent-inhibited rhesus monkey and human AChEs, reactivation by H oximes accelerated as the size of the OR group was increased. But with guinea pig AChE, reactivation by H oximes declined as the size of the OR group was increased. Reactivation kinetic study using GF- and VR-inhibited wild-type and mutant bovine AChEs has shown that mutations of Y124Q and W286A particularly reduced reactivation by these H oximes. Since these 2 amino acid residues are highly conserved in all AChEs sequenced to date, it is unlikely that the remarkable reduction observed in H oxime reactivation with guinea pig AChE is caused by a change in these two amino acid residues. Published by Elsevier Ireland Ltd. C1 [Luo, Chunyuan; Yang, Yerie; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Chambers, Carolyn] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Luo, CY (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Chunyuan.luo@us.army.mil NR 30 TC 7 Z9 7 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 185 EP 190 DI 10.1016/j.cbi.2010.01.018 PG 6 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600033 PM 20096273 ER PT J AU Demar, JC Clarkson, ED Ratcliffe, RH Campbell, AJ Thangavelu, SG Herdman, CA Leader, H Schulz, SM Marek, E Medynets, MA Ku, TC Evans, SA Khan, FA Owens, RR Nambiar, MP Gordon, RK AF DeMar, James C. Clarkson, Edward D. Ratcliffe, Ruthie H. Campbell, Amy J. Thangavelu, Sonia G. Herdman, Christine A. Leader, Haim Schulz, Susan M. Marek, Elizabeth Medynets, Marie A. Ku, Therese C. Evans, Sarah A. Khan, Farhat A. Owens, Roberta R. Nambiar, Madhusoodana P. Gordon, Richard K. TI Pro-2-PAM therapy for central and peripheral cholinesterases SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Acetylcholinesterase; Diisopropylfluorophosphate; Electroencephalogram (EEG); Guinea pigs; Organophosphate agent; Pro-2-pralidoxime; Soman (GD); Status epilepticus ID SOMAN; SARIN; ACETYLCHOLINESTERASE; INHIBITION; DELIVERY; PLASMA; RAT AB Novel therapeutics to overcome the toxic effects of organophosphorus (OP) chemical agents are needed due to the documented use of OPs in warfare (e.g. 1980-1988 Iran/Iraq war) and terrorism (e.g. 1995 Tokyo subway attacks). Standard OP exposure therapy in the United States consists of atropine sulfate (to block muscarinic receptors), the acetylcholinesterase (AChE) reactivator (oxime) pralidoxime chloride (2-PAM), and a benzodiazepine anticonvulsant to ameliorate seizures. A major disadvantage is that quaternary nitrogen charged oximes, including 2-PAM, do not cross the blood brain barrier (BBB) to treat brain AChE. Therefore, we have synthesized and evaluated pro-2-PAM (a lipid permeable 2-PAM derivative) that can enter the brain and reactivate CNS AChE, preventing seizures in guinea pigs after exposure to OPs. The protective effects of the pro-2-PAM after OP exposure were shown using (a) surgically implanted radiotelemetry probes for electroencephalogram (EEG), (b) neurohistopathology of brain, (c) cholinesterase activities in the PNS and CNS, and (d) survivability. The PNS oxime 2-PAM was ineffective at reducing seizures/status epilepticus (SE) in diisopropylfluorophosphate (DFP)-exposed animals. In contrast, pro-2-PAM significantly suppressed and then eliminated seizure activity. In OP-exposed guinea pigs, there was a significant reduction in neurological damage with pro-2-PAM but not 2-PAM. Distinct regional areas of the brains showed significantly higher AChE activity 1.5 h after OP exposure in pro-2-PAM treated animals compared to the 2-PAM treated ones. However, blood and diaphragm showed similar AChE activities in animals treated with either oxime, as both 2-PAM and pro-2-PAM are PNS active oximes. In conclusion, pro-2-PAM can cross the BBB, is rapidly metabolized inside the brain to 2-PAM, and protects against OP-induced SE through restoration of brain AChE activity. Pro-2-PAM represents the first non-invasive means of administering a CNS therapeutic for the deleterious effects of OP poisoning by reactivating CNS AChE. Published by Elsevier Ireland Ltd. C1 [DeMar, James C.; Ratcliffe, Ruthie H.; Thangavelu, Sonia G.; Herdman, Christine A.; Marek, Elizabeth; Medynets, Marie A.; Ku, Therese C.; Evans, Sarah A.; Khan, Farhat A.; Gordon, Richard K.] Walter Reed Army Inst Res, Div Regulated Activ, DRL, Silver Spring, MD 20910 USA. [Campbell, Amy J.; Owens, Roberta R.] Walter Reed Army Inst Res, Div Biochem, Dept Biochem Pharmacol, Silver Spring, MD 20910 USA. [Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Div Brain Dysfunct & Blast Injury, Dept Closed Head Injury, Silver Spring, MD 20910 USA. [Clarkson, Edward D.; Schulz, Susan M.] USA, Med Res Inst Chem Def, MCMR UV DB, Aberdeen Proving Ground, MD 21010 USA. [Leader, Haim] Weizmann Inst Sci, IL-76100 Rehovot, Israel. [DeMar, James C.; Thangavelu, Sonia G.; Herdman, Christine A.; Marek, Elizabeth; Medynets, Marie A.; Ku, Therese C.; Khan, Farhat A.] Geneva Fdn, Lakewood, WA 98498 USA. RP Gordon, RK (reprint author), Walter Reed Army Inst Res, Div Regulated Activ, DRL, 503 Robert Grant Ave,Room 2W105, Silver Spring, MD 20910 USA. EM Richard.Gordon@amedd.army.mil RI Ratcliffe, Ruthie/B-6815-2011; OI Herdman, Christine/0000-0001-9019-4491 FU NINDS NIH HHS [U01 NS058166-04, U01 NS058166, U01 NS058166-01, U01 NS058166-02, U01 NS058166-03] NR 25 TC 26 Z9 31 U1 2 U2 13 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 191 EP 198 DI 10.1016/j.cbi.2010.02.015 PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600034 PM 20156430 ER PT J AU Garcia, GE Campbell, AJ Olson, J Moorad-Doctor, D Morthole, VI AF Garcia, Gregory E. Campbell, Amy J. Olson, John Moorad-Doctor, Deborah Morthole, Venee I. TI Novel oximes as blood-brain barrier penetrating cholinesterase reactivators SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Acetylcholinesterase; Blood-brain barrier; Central nervous system; Organophosphates; Reactivation; Sugar-oxime ID GLYCOSYL DERIVATIVES; PRODRUGS; ANTIDOTES; STABILITY; DOPAMINE; HI-6 AB The US Army utilizes pralidoxime (2-PAM) for the reactivation of OP-inhibited AChE. While 2-PAM effectively reactivates acetylcholinesterase (AChE) in the body, it does not cross the blood-brain barrier (BBB) at therapeutically relevant levels. To address this problem of central nervous system AChE reactivation, novel sugar-oxime conjugates were utilized. These 'sugar-oximes' would potentially be transported across the BBB because they contain a sugar moiety which would be recognized by the facilitative glucose transporters. Eight previously reported, but understudied sugar-oximes, as well as six novel sugar-oximes were synthesized, and their ability to reactivate both human red blood cell AChE and plasma butyrylcholinesterase poisoned with DFP, paraoxon, sarin and VX were tested. The results show that the novel sugar-oxime 13c was more active than the other compounds with a reactivation potential similar to 2-PAM. The sugar-oxime 8b had low toxicity with a LD(50) of 1590 mg/kg from a single IM dose in the guinea pig and >2000 mg/kg IP in the mouse. Histopathological analysis showed that there were no apparent differences in hippocampus, heart, liver, kidney sciatic nerve, or skeletal muscle between treated and untreated animals. These results show that sugar-oximes can be effective reactivators and suggest that high treatment doses may be possible. Published by Elsevier Ireland Ltd. C1 [Garcia, Gregory E.; Campbell, Amy J.; Olson, John; Moorad-Doctor, Deborah] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Moorad-Doctor, Deborah; Morthole, Venee I.] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. RP Garcia, GE (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Forney Ave, Silver Spring, MD 20910 USA. EM gregory.e.garcia@us.army.mil NR 22 TC 27 Z9 29 U1 4 U2 15 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 199 EP 206 DI 10.1016/j.cbi.2010.02.033 PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600035 PM 20227398 ER PT J AU Shih, TM Skovira, JW O'Donnell, JC McDonough, JH AF Shih, Tsung-Ming Skovira, Jacob W. O'Donnell, John C. McDonough, John H. TI In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Acetylcholinesterase; Cholinesterase reactivation; Guinea pig; Methoxime; Nerve agents; Oximes ID HUMAN ACETYLCHOLINESTERASES; ORGANOPHOSPHORUS COMPOUNDS; PYRIDINIUM OXIMES; VITRO; HI-6; SAD-128; MONKEY; MUSCLE; 2-PAM; RATS AB This study compared the ability of nine oximes (HI-6, HLo7, MMB-4, TMB-4, carboxime, ICD585, ICD692, ICD3805, and 2-PAM) to reactivate in vivo cholinesterase (ChE) in blood, brain, and peripheral tissues in guinea pigs intoxicated by one of four organophosphorus nerve agents. Two bis-pyridinium compounds without an oxime group, SAD128 and ICD4157, served as non-oxime controls. Animals were injected subcutaneously with 1.0 x LD(50) of the nerve agents sarin, cyclosarin, VR or VX and treated intramuscularly 5 min later with one of these oximes. Toxic signs and lethality were monitored; tissue ChE activities were determined at 60 min after nerve agent. Some animals exposed to sarin or cyclosarin, with or without non-oxime treatment, died within 60 min; however, no animal treated with an oxime died. For VR or VX, all animals survived the 60 min after exposure, with or without non-oxime or oxime therapy. The four nerve agents caused differential degrees of inhibition in blood, brain regions and peripheral tissues. The tested oximes exhibited differential potency in reactivating nerve agent-inhibited ChE in various peripheral tissues, but did not affect ChE activity in the brain regions. There was no direct relation between blood and peripheral tissues in the reactivating efficacy of oxime treatments. ChE inhibited by satin was the most susceptible to oxime reactivation while cyclosarin the least susceptible. There was no difference in the ChE reactivating potency between the dimethanesulfonate and dichloride salts of HI-6. MMB-4 significantly reactivated the ChE inhibited by these four nerve agents in blood and all three peripheral tissues of the guinea pig, and among all the oximes tested it was the most effective in vivo ChE reactivator against all four nerve agents. Published by Elsevier Ireland Ltd. C1 [Shih, Tsung-Ming] USA, Med Res Inst Chem Def, ATTN MCMR CDR P Dr TM Shih, Pharmacol Branch,Res Div, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), USA, Med Res Inst Chem Def, ATTN MCMR CDR P Dr TM Shih, Pharmacol Branch,Res Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih@us.army.mil NR 30 TC 28 Z9 31 U1 0 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 207 EP 214 DI 10.1016/j.cbi.2010.03.006 PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600036 PM 20223229 ER PT J AU Cadieux, CL Broomfield, CA Kirkpatrick, MG Kazanski, ME Lenz, DE Cerasoli, DM AF Cadieux, C. Linn Broomfield, Clarence A. Kirkpatrick, Melanie G. Kazanski, Meghan E. Lenz, David E. Cerasoli, Douglas M. TI Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Guinea pig; Acetylcholinesterase; Gene; Nucleotide; Protein; Oxime; Reactivation ID CARBOXYLESTERASE INHIBITION; ORGANOPHOSPHORUS COMPOUNDS; SOMAN TOXICITY; MODEL; KINETICS; WEB AB Poisoning via organophosphorus (OP) nerve agents occurs when the OP binds and inhibits the enzyme acetylcholinesterase (AChE). This enzyme is responsible for the metabolism of the neurotransmitter acetylcholine (ACh) which transmits signals between nerves and several key somatic regions. When AChE is inhibited, the signal initiated by ACh is not properly terminated. Excessive levels of ACh result in a cholinergic crisis, and in severe cases can lead to death. Current treatments for OP poisoning involve the administration of atropine, which blocks ACh receptors, and oximes, which reactivate AChE after inhibition. Efforts to improve the safety, efficacy, and broad spectrum utility of these treatments are ongoing and usually require the use of appropriate animal model systems. For OP poisoning, the guinea pig (Cavia porcellus) is a commonly used animal model because guinea pigs more closely mirror primate susceptibility to OP poisoning than do other animals such as rats and mice. This is most likely because among rodents and other small mammals, guinea pigs have a very low relative concentration of serum carboxylesterase, an enzyme known to bind OPs in vitro and to act as an endogenous bioscavenger in vivo. Although guinea pigs historically have been used to test OP poisoning therapies, it has been found recently that guinea pig AChE is substantially more resistant to oxime-mediated reactivation than human AChE. To examine the molecular basis for this difference, we reverse transcribed mRNA encoding guinea pig AChE, amplified the resulting cDNA, and sequenced this product. The nucleotide and deduced amino acid sequences of guinea pig AChE were then compared to the human version. Several amino acid differences were noted, and the predicted locations of these differences were mapped onto a structural model of human AChE. To examine directly how these differences affect oxime-mediated reactivation of AChE after inhibition by OPs, human and guinea pig red blood cell ghosts were prepared and used as sources of AChE, and the relative capacity of several different oximes to reactivate each OP-inhibited AChE were determined. The differences we report between human and guinea pig AChE raise additional concerns about the suitability of the guinea pig as an appropriate small animal model to approximate human responses to OP poisoning and therapies. (C) 2010 Elsevier Ireland Ltd. All rights reserved. C1 [Cadieux, C. Linn; Broomfield, Clarence A.; Kirkpatrick, Melanie G.; Kazanski, Meghan E.; Lenz, David E.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Cadieux, CL (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM christena.l.cadieux@us.army.mil NR 13 TC 5 Z9 5 U1 2 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 229 EP 233 DI 10.1016/j.cbi.2010.04.020 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600040 PM 20433814 ER PT J AU Lenz, DE Clarkson, ED Schulz, SM Cerasoli, DM AF Lenz, David E. Clarkson, Edward D. Schulz, Susan M. Cerasoli, Douglas M. TI Butyrylcholinesterase as a therapeutic drug for protection against percutaneous VX SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Butyrylcholinesterase; Bioscavenger; organophosphorus compound; Therapeutics; Nerve agent poisoning; VX ID RECOMBINANT HUMAN BUTYRYLCHOLINESTERASE; ACETYLCHOLINESTERASE PROPHYLAXIS; SOMAN TOXICITY; RHESUS-MONKEYS; CHOLINESTERASES AB The administration of purified human plasma-derived butyrylcholinesterase (HuBuChE) as a pretreatment has been demonstrated to enhance survival and protect against decreased cognitive function after exposure to organophosphorus poisons (OPs). Based on efficacy data obtained with guinea pigs and non-human primates and the lack of behavioral side effects, plasma-derived HuBuChE has been granted investigational new drug status by the US Food and Drug Administration. The recent availability of a recombinant form of HuBuChE (rHuBuChE) from the milk of transgenic goats has now allowed us to determine the pharmacokinetics of that material in guinea pigs and use it as a therapy following exposure to the VX. The rHuBuChE was expressed as a dimer and following intramuscular (i.m.) administration had more a rapid adsorption and clearance profile in guinea pigs than the plasma-derived material. Based on those data, we administered rHuBuChE i.m. 1 h after a percutaneous exposure of guinea pigs to either 2xLD(50) or 5xLD(50) of VX. Post-exposure therapy with rHuBuChE provided improved survival at both challenge levels, 90% and 33% respectively versus 20% or 0% respectively for animals that did not receive therapy. These studies showed that BuChE can be efficacious as a therapy against percutaneous exposure to VX. Published by Elsevier Ireland Ltd. C1 [Lenz, David E.; Clarkson, Edward D.; Schulz, Susan M.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Lenz, DE (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM david.lenz@us.army.mil NR 21 TC 15 Z9 15 U1 0 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 249 EP 252 DI 10.1016/j.cbi.2010.05.014 PG 4 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600045 PM 20513442 ER PT J AU Rosenberg, YJ Saxena, A Sun, W Jiang, XM Chilukuri, N Luo, CJ Doctor, BP Lee, KD AF Rosenberg, Yvonne J. Saxena, Ashima Sun, Wei Jiang, Xiaoming Chilukuri, Nageswararao Luo, Chunjuan Doctor, Bhupendra P. Lee, Keunmyoung D. TI Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Macaque; Butyrylcholinesterase; Homologous model; Pharmacokinetics; Immunogenicity ID N-GLYCOLYLNEURAMINIC ACID; HALF-LIFE; TOXICITY; ACETYLCHOLINESTERASE; PROTECTION; PHARMACOKINETICS; CHOLINESTERASE; MONKEYS; PLASMA; MUTANT AB Human serum and recombinant butyrylcholinesterase (rHuBChE) are the most advanced prophylactics against organophosphate (OP) toxicity due to nerve agent or insecticide exposure. For ethical reasons, such potential multi-use treatments cannot be tested in humans and will require extensive testing in animal models and the "Animal Rule" 21 (21 CFR 601.90) for regulatory approval. This will involve multiple injections of rHuBChE into heterologous animals, e.g. macaques, rodents with inevitable immunogenicity and subsequent elimination of the enzyme on repeat injections. In order to accurately assess pharmacokinetics, efficacy and safety of a candidate rBChE in an "antibody free" system, a homologous macaque (Ma) model has been developed. In these studies, macaques received single or multiple intravenous injections of native MaBChE as well as unmodified or PEG-conjugated forms of rMaBChE produced in CHO cells. Compared to the poor plasma retention of unmodified rBChE (MRT: <10 h), three injections of 1.5-2.3 mg/kg of PEG-conjugated tetrameric rBChE resulted in high circulatory stability (MRT: >134 h) and lack of immunogenicity similar to native MaBChE. PEG-conjugation of the monomeric rMaBChE form also exhibited pharmacokinetic profiles comparable to the tetrameric form (MRT: >113 h). However, despite the increased bioavailability of PEG-rBChE, antigenicity studies using sandwich ELISA showed that while macaque BChE was not immunogenic in macaques, PEGylation of rMaBChE did not prevent binding to anti-BChE antibodies, suggesting PEGylation may not be sufficient to mask non-human epitopes on rBChE. This homologous model can provide necessary preclinical protection data for the use of PEG-rHuBChE in humans and bodes well for a safe and efficacious CHO-derived rHuBChE therapeutic. (C) 2010 Elsevier Ireland Ltd. All rights reserved. C1 [Rosenberg, Yvonne J.; Jiang, Xiaoming; Lee, Keunmyoung D.] PlantVax Inc, Rockville, MD 20850 USA. [Chilukuri, Nageswararao; Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Rosenberg, YJ (reprint author), PlantVax Inc, Suite 120,9430 Key W Ave, Rockville, MD 20850 USA. EM yjr@plantvax.com NR 31 TC 22 Z9 22 U1 0 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 279 EP 286 DI 10.1016/j.cbi.2010.02.042 PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600050 PM 20211615 ER PT J AU Mumford, H Price, ME Cerasoli, DM Teschner, W Ehrlich, H Schwarz, HP Lenz, DE AF Mumford, Helen Price, Matthew E. Cerasoli, Douglas M. Teschner, Wolfgang Ehrlich, Hartmut Schwarz, Hans Peter Lenz, David E. TI Efficacy and physiological effects of human butyrylcholinesterase as a post-exposure therapy against percutaneous poisoning by VX in the guinea-pig SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Bioscavenger; Nerve agent; Percutaneous; Guinea-pig ID RECOMBINANT HUMAN BUTYRYLCHOLINESTERASE; HUMAN SERUM BUTYRYLCHOLINESTERASE; CYNOMOLGUS MONKEYS; PROTECTION; SOMAN; PRETREATMENT; EXPOSURE AB The physiological effects of human plasma-derived butyrylcholinesterase (huBuChE) administration and its modulation of the effects of percutaneous VX challenge are poorly understood. Percutaneously administered nerve agents are more slowly absorbed than inhaled agents; consequently, signs of poisoning occur later, with a longer duration. Telemetry was used to monitor heart rate. EEG, temperature and activity in guinea-pigs. Treatment with huBuChE at 30 or 120 min following percutaneous VX challenge (similar to 2.5 x LD(50)) provided 100% protection from lethality. When huBuChE administration was delayed until the onset of observable signs of poisoning only 1 out of 6 animals survived to the end of the experiment at 7 days. This study adds to the body of evidence demonstrating the efficacy of huBuChE in animals by describing the successful therapeutic use of a protein bioscavenger as a post-exposure treatment against dermal exposure to VX up to 2 h post-exposure. This study simultaneously used telemetric methods to show that the efficacy of huBuChE is linked to the prevention of detrimental physiological changes observed in control VX-treated animals. Post-exposure therapy is a promising additional indication for the concept of use of this material, and one that has particular relevance in a civilian exposure scenario. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved. C1 [Mumford, Helen; Price, Matthew E.] Dstl Porton Down, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England. [Cerasoli, Douglas M.; Lenz, David E.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Teschner, Wolfgang; Ehrlich, Hartmut; Schwarz, Hans Peter] Baxter Innovat GmbH Ind Str, A-1221 Vienna, Austria. RP Mumford, H (reprint author), Dstl Porton Down, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England. EM hmumford@dstl.gov.uk OI Rice, Helen/0000-0002-7813-9374 NR 22 TC 7 Z9 7 U1 0 U2 4 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 304 EP 308 DI 10.1016/j.cbi.2010.02.020 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600055 PM 20176007 ER PT J AU Chanda, S Song, JA Rezk, P Sabnekar, P Doctor, BP Sciuto, AM Nambiar, MP AF Chanda, Soma Song, Jian Rezk, Peter Sabnekar, Praveena Doctor, Bhupendra P. Sciuto, Alfred M. Nambiar, Madhusoodana P. TI Gastrointestinal acetylcholinesterase activity following endotracheal microinstillation inhalation exposure to sarin in guinea pigs SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Sarin; Gastrointestinal tract; Acetylcholinesterase; Endotracheal microinstillation; Inhalation exposure; Chemical warfare nerve agents AB The goal of this study was to assess acetylcholinesterase (AChE) inhibition at different regions of the gastrointestinal (GI) tract following inhalation exposure to nerve agent sarin. Seven major regions of the GI tract were removed from saline control animals (n = 3) and 677.4 mg/m(3) sarin-exposed animals at 4 h (n = 4) and 24 h (n = 4) post-exposure. AChE activity was determined in blood and homogenized tissue supernatant by specific Ellman's assay using Iso-OMPA, a BChE inhibitor, and expressed as activity/optical density of hemoglobin for blood and activity/mg protein for tissues. Our data showed that the AChE activity was significantly decreased for groups both 4 h and 24 h post-sarin exposure. Among the seven chosen regions of the guinea pig GI tract, duodenum showed the highest AChE activity in control animals. The AChE activity was significantly decreased in the stomach (p = 0.03), duodenum (p = 0.029), jejunum (p = 0.006), and ileum (p = 0.006) 4 h following sarin exposure. At 24 h post-sarin exposure the AChE activity of duodenum (p = 0.029) and ileum (p = 0.006) was significantly inhibited. Esophagus showed no inhibition following sarin exposure at both 4 h and 24 h groups. These results suggest that the AChE activity is different in different regions of the GI tract and highest levels of AChE inhibition following sarin exposure were seen in regions exhibiting higher overall AChE activity and cholinergic function. Published by Elsevier Ireland Ltd. C1 [Chanda, Soma; Song, Jian; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Div Brain Dysfunct & Blast Injury, Silver Spring, MD 20910 USA. [Rezk, Peter; Sabnekar, Praveena; Sciuto, Alfred M.] USA, Med Res Inst Chem Def, Med Toxicol Branch, Analyt Toxicol Div, Edgewood, MD 21010 USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Div Brain Dysfunct & Blast Injury, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM madhusoodana.nambiar@amedd.army.mil FU NIEHS NIH HHS [5U01ES015677] NR 9 TC 3 Z9 3 U1 0 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 309 EP 311 DI 10.1016/j.cbi.2010.03.011 PG 3 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600056 PM 20227400 ER PT J AU Skovira, JW O'Donnell, JC Koplovitz, I Kan, RK McDonough, JH Shih, TM AF Skovira, Jacob W. O'Donnell, John C. Koplovitz, Irwin Kan, Robert K. McDonough, John H. Shih, Tsung-Ming TI Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Acetylcholinesterase; Brain; Central nervous system; Cholinesterase reactivation; Cyclosarin; Guinea pig; Monoisonitrosoacetone; Nerve agents; Oximes; Pralidoxime; Protective ratio; Sarin; Survival; VX ID INDUCED SEIZURES; OXIMES; PHYSOSTIGMINE; HYOSCINE; STAGEWISE; ATROPINE; LETHAL; SOMAN AB Current oxime therapies do not readily cross the blood-brain barrier to reactivate organophosphorus nerve agent-inhibited cholinesterase (ChE) within the CNS. We investigated the ability of monoisonitrosoacetone (MINA), a tertiary oxime, to reactivate ChE inhibited by the nerve agent sarin (GB), cyclosarin (GF), or VX, in peripheral tissues and brain of guinea pigs and determined whether reactivation in the CNS will enhance protection against the lethal effects of these three agents. In the reactivation experiment, animals were pretreated with atropine methylnitrate (1.0 mg/kg, i.m.) 15 min prior to subcutaneous (s.c.) challenge with 1.0x LD(50) of GB, GF, or VX. Fifteen minutes later animals were treated intramuscularly (i.m.) with MINA (ranging from 22.1 to 139.3 mg/kg) or 2-PAM (25.0 mg/kg). At 60 min after nerve agent, CNS (brainstem, cerebellum, cortex, hippocampus, midbrain, spinal cord, and striatum) and peripheral (blood, diaphragm, heart, and skeletal muscle) tissues were collected for ChE analysis. MINA reactivated nerve agent-inhibited ChE in the CNS and peripheral tissues in a dose-dependent manner in the following order of potency: GB > GF > VX. In a survival experiment, animals were injected i.m. with atropine sulfate (0.5 mg/kg), 2-PAM (25.0 mg/kg), or MINA (35.0.60.0. or 100.0 mg/kg) alone or in combination 1 min after challenge with varying s.c. doses of GB, GF, or VX to determine the level of protection. The rank order of MINA's efficacy in guinea pigs against nerve agent lethality was the same as for reactivation of inhibited ChE in the CNS. These data show that MINA is capable of reactivating nerve agent-inhibited ChE and that the extent of ChE reactivation within the CNS strongly relates to its therapeutic efficacy. Published by Elsevier Ireland Ltd. C1 [Shih, Tsung-Ming] USA, Med Res Inst Chem Def, ATTN MCMR CDR P, Pharmacol Branch,Res Div, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), USA, Med Res Inst Chem Def, ATTN MCMR CDR P, Pharmacol Branch,Res Div, 3100 Ricketts Point, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih@us.army.mil NR 30 TC 33 Z9 34 U1 2 U2 12 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 318 EP 324 DI 10.1016/j.cbi.2010.03.010 PG 7 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600058 PM 20230808 ER PT J AU Ditargiani, RC Chandrasekaran, L Belinskaya, T Saxena, A AF diTargiani, Robert C. Chandrasekaran, Lakshmi Belinskaya, Tatyana Saxena, Ashima TI In search of a catalytic bioscavenger for the prophylaxis of nerve agent toxicity SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Bioscavenger; Catalytic; Stoichiometric; OP poisoning; Prolidase; PON1; SMP-30 ID HUMAN SERUM PARAOXONASE; SENESCENCE MARKER PROTEIN-30; HUMAN LIVER PROLIDASE; DIISOPROPYL PHOSPHOROFLUORIDATE; COLORIMETRIC DETERMINATION; SACCHAROMYCES-CEREVISIAE; PURIFICATION; ENZYME; ACETYLCHOLINESTERASE; SOMAN AB A novel approach for treating organophosphorus (OP) poisoning is the use of enzymes, both stoichiometric and catalytic, as bioscavengers to sequester these compounds in circulation before they reach their physiological targets. Human serum butyrylcholinesterase and a recombinant form of this enzyme produced in the milk of transgenic goats have completed Phase I clinical trials as stoichiometric bioscavengers for the protection of humans against OP nerve agents. However, a major limitation of the first generation bioscavenger is the 1:1 stoichiometry between the enzyme and the OP. Therefore, efforts are underway to develop the second generation catalytic bioscavenger, which will neutralize/hydrolyze multiple OP molecules. To avoid any complications related to adverse immune reactions, three enzymes from human (Hu) sources are being considered for development as catalytic bioscavengers: (1) prolidase; (2) paraoxonase 1 (PON1); (3) senescence marker protein-30 (SMP-30). Towards this effort, native or recombinant (r) forms of candidate catalytic bioscavengers were isolated and characterized for their ability to hydrolyze G-type nerve agents at concentrations of 10 mu M and 1 mM. Results show that mammalian enzymes were significantly less efficient at hydrolyzing nerve agents as compared to bacterial organophosphorus hydrolase (OPH) and organophosphorus acid anhydrolase (OPAA). Recombinant Hu prolidase was the most efficient and the only mammalian enzyme that hydrolyzed all four G-type nerve agents. On the other hand, both rHu PON1 and Mo SMP-30 showed 10-fold lower activity towards sarin compared to rHu prolidase and did not hydrolyze tabun. Based on these results, Hu prolidase appears to be the most promising candidate for further development: (1) it can be easily expressed in E. coli; (2) of the three candidate enzymes, it is the only enzyme that hydrolyzes all four G-type agents. Efforts to improve the catalytic efficiency of this enzyme towards OP nerve agents are underway. Published by Elsevier Ireland Ltd. C1 [diTargiani, Robert C.; Chandrasekaran, Lakshmi; Belinskaya, Tatyana; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Ashima.saxena@us.army.mil NR 37 TC 33 Z9 36 U1 1 U2 7 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 349 EP 354 DI 10.1016/j.cbi.2010.02.021 PG 6 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600064 PM 20176006 ER PT J AU Otto, TC Kasten, SA Kovaleva, E Liu, Z Buchman, G Tolosa, M Davis, D Smith, JR Balcerzak, R Lenz, DE Cerasoli, DM AF Otto, Tamara C. Kasten, Shane A. Kovaleva, Elena Liu, Zhi Buchman, George Tolosa, Marita Davis, David Smith, J. Richard Balcerzak, Robert Lenz, David E. Cerasoli, Douglas M. TI Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Organophosphorus; Nerve agent; Catalytic bioscavenger ID HUMAN SERUM PARAOXONASE; HYDROLYSIS; PON1 AB Human serum paraoxonase-1 (HuPON1) is difficult to either purify from plasma or functionally express in high yield from recombinant sources. Here, we describe the characterization of functional HuPON1 expressed and purified from Trichoplusia ni (T. ni) larvae infected with an orally active form of baculovirus. SOS-PAGE and anti-HuPON1 Western blot analyses yielded only three bands of approximately 41, 42, and 44 kDa. MALDI-TOF confirmed the identity of each of these bands as HuPON1 with greater than 95% confidence. These isoforms result from differential glycosylation of the enzyme as indicated by peptide mapping, mass analysis, and PNGase F deglycosylation experiments. Recombinant insect-produced HuPON1 hydrolyzed phenyl acetate, paraoxon, and the nerve agents GF, VX, and VR. The enzyme had dramatic stereoselectivity for the P+ isomers of VX and VR. T. ni larvae expressing HuPON1 were remarkably resistant to the pesticide chlorpyrifos. Together, these results demonstrate that the caterpillar of the T. ni moth can be used as an expression system to produce large quantities of functional recombinant HuPON1. Insect production of HuPON1 may provide a source for both in vitro enzymatic and crystallographic studies and in vivo stability and anti-nerve agent efficacy testing. Published by Elsevier Ireland Ltd. C1 [Otto, Tamara C.; Kasten, Shane A.; Lenz, David E.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA. [Kovaleva, Elena; Liu, Zhi; Buchman, George; Tolosa, Marita; Davis, David; Balcerzak, Robert] Chesapeake PERL Inc, Savage, MD 20763 USA. [Smith, J. Richard] USA, Med Res Inst Chem Def, Med Diagnost & Chem Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Cerasoli, DM (reprint author), USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM douglas.cerasoli@us.army.mil NR 14 TC 24 Z9 25 U1 0 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 388 EP 392 DI 10.1016/j.cbi.2010.02.022 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600071 PM 20176005 ER PT J AU Haigh, JR Adler, M Apland, JP Deshpande, SS Barham, CB Desmond, P Koplovitz, I Lenz, DE Gordon, RK AF Haigh, Julian R. Adler, Michael Apland, James P. Deshpande, Sharad S. Barham, Charles B. Desmond, Patrick Koplovitz, Irwin Lenz, David E. Gordon, Richard K. TI Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 10th International Meeting on Cholinesterases CY SEP 20-25, 2009 CL Sibenik, CROATIA SP Inst Med Res & Occupat Hlth, Croatian Soc Biochem & Mole Biol, Croatian Acad Sci & Arts DE Acetylcholinesterase; Marmoset; Hemi-diaphragm muscle; Soman; Pyridostigmine bromide; WRAIR cholinesterase assay ID NERVE AGENTS; BLOOD CHOLINESTERASES; HUPERZINE; PRETREATMENT; PROPHYLAXIS; INHIBITION; RAT AB Pyridostigmine bromide (PB) was approved by the U.S. Food and Drug Administration (FDA) in 2003 as a pretreatment in humans against the lethal effects of the irreversible nerve agent soman (GD). Organophosphate (OP) chemical warfare agents such as GD exert their toxic effects by inhibiting acetylcholinesterase (AChE) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). As part of the post-marketing approval of PB, the FDA required (under 21CFR314, the "two animal rule") the study of a non-human primate model (the common marmoset Callithrix jacchus jacchus) to demonstrate increased survival against lethal GD poisoning, and protection of physiological hemi-diaphragm function after PB pretreatment and subsequent GD exposure. Marmosets (male and female) were placed in the following experimental groups: (i) control (saline pretreatment only), (ii) low dose PB (12.5 mu g/kg), or (iii) high dose (39.5 mu g/kg) PB. Thirty minutes after the PB dose, animals were challenged with either saline (control) or soman (GD, 45 mu g/kg), followed 1 min later by atropine (2 mg/kg) and 2-PAM (25 mg/kg). After a further 16 min, animals were euthanized and the complete diaphragm removed: the right hemi-diaphragm was frozen immediately at -80 degrees C, and the left hemi-diaphragm was placed in a tissue bath for 4 h (to allow for decarbamylation to occur), then frozen. AChE activities were determined using the automated WRAIR cholinesterase assay. Blood samples were collected for AChE activities prior to PB, before GD challenge, and after sacrifice. RBC-AChE was inhibited by approximately 18% and 50% at the low and high doses of PB, respectively, compared to control (baseline) activity. In the absence of PB pretreatment, the inhibition of RBC-AChE by GD was 98%. The recovery of hemi-diaphragm AChE activity after the 4 h wash period (decarbamylation) was approximately 8% and 17%, at the low and high PB doses, respectively, compared with the baseline (control) AChE activity prior to PB pretreatment or soman exposure. The results suggest that PB pretreatment protects a critical fraction of AChE activity in the marmoset diaphragm, which is sufficient to allow the animal to breathe despite exposure to a dose of soman that is lethal in unprotected animals. (C) 2010 Elsevier Ireland Ltd. All rights reserved. C1 [Haigh, Julian R.; Barham, Charles B.; Desmond, Patrick; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Regulated Labs, Silver Spring, MD 20910 USA. [Adler, Michael; Apland, James P.; Deshpande, Sharad S.; Koplovitz, Irwin; Lenz, David E.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Haigh, JR (reprint author), Walter Reed Army Inst Res, Dept Regulated Labs, Silver Spring, MD 20910 USA. EM julian.haigh@amedd.army.mil NR 17 TC 10 Z9 13 U1 2 U2 11 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 6 PY 2010 VL 187 IS 1-3 SI SI BP 416 EP 420 DI 10.1016/j.cbi.2010.02.003 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 641EW UT WOS:000281108600077 PM 20144889 ER PT J AU Rooijakkers, SHM Rasmussen, SL McGillivray, SM Bartnikas, TB Mason, AB Friedlander, AM Nizet, V AF Rooijakkers, Suzan H. M. Rasmussen, Suzanne L. McGillivray, Shauna M. Bartnikas, Thomas B. Mason, Anne B. Friedlander, Arthur M. Nizet, Victor TI Human Transferrin Confers Serum Resistance against Bacillus anthracis SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID CRYSTAL-STRUCTURE; BACTERIAL PATHOGENS; INNATE IMMUNITY; LETHAL TOXIN; IRON; LACTOFERRIN; MICE; BINDING; ACQUISITION; COMPLEMENT AB The innate immune system in humans consists of both cellular and humoral components that collaborate to eradicate invading bacteria from the body. Here, we discover that the Gram-positive bacterium Bacillus anthracis, the causative agent of anthrax, does not grow in human serum. Fractionation of serum by gel filtration chromatography led to the identification of human transferrin as the inhibiting factor. Purified transferrin blocks growth of both the fully virulent encapsulated B. anthracis Ames and the non-encapsulated Sterne strain. Growth inhibition was also observed in serum of wild-type mice but not of hypotransferrinemic mice that only have similar to 1% circulating transferrin levels. We were able to definitely assign the bacteriostatic activity of transferrin to its iron-binding function: neither iron-saturated transferrin nor a recombinant transferrin mutant unable to bind iron could inhibit growth of B. anthracis. Additional iron could restore bacterial growth in human serum. The observation that other important Gram-positive pathogens are not inhibited by transferrin suggests they have evolved effective mechanisms to circumvent serum iron deprivation. These findings provide a better understanding of human host defense mechanisms against anthrax and provide a mechanistic basis for the antimicrobial activity of human transferrin. C1 [Rooijakkers, Suzan H. M.] Univ Med Ctr Utrecht, NL-3584 CX Utrecht, Netherlands. [Nizet, Victor] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA. [Nizet, Victor] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA. [Rasmussen, Suzanne L.; Friedlander, Arthur M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Bartnikas, Thomas B.] Childrens Hosp, Dept Pathol, Boston, MA 02115 USA. [Mason, Anne B.] Univ Vermont, Dept Biochem, Coll Med, Burlington, VT 05405 USA. [Nizet, Victor] Rady Childrens Hosp, San Diego, CA 92123 USA. RP Rooijakkers, SHM (reprint author), Univ Med Ctr Utrecht, G04-614, NL-3584 CX Utrecht, Netherlands. EM s.h.m.rooijakkers@umcutrecht.nl FU National Institutes of Health [AI077780, DK084122-01, DK21739]; European Organization of Molecular Biology (EMBO); NIGMS [GM068524]; Hartwell Foundation FX This work was supported, in whole or in part, by the National Institutes of Health Grants AI077780 (to V. N.), DK084122-01 (to T. B. B.), and DK21739 (to A. B. M.). This work was also supported by the European Organization of Molecular Biology (EMBO) (to S. H. M. R.).; Supported by an IRACDA postdoctoral fellowship from NIGMS (GM068524) and a Biomedical Research Fellowship from The Hartwell Foundation. NR 42 TC 20 Z9 20 U1 0 U2 4 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD SEP 3 PY 2010 VL 285 IS 36 BP 27609 EP 27613 DI 10.1074/jbc.M110.154930 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 644TL UT WOS:000281404100016 PM 20615872 ER PT J AU Mcveigh, BAB Geibel, JJ Kalvass, PE AF Mcveigh, Brooke A. B. Geibel, John J. Kalvass, Peter E. TI SPORT CLAMMING IN HUMBOLDT BAY, CALIFORNIA DURING 2008: COMPARISONS WITH HISTORICAL SURVEY DATA SO CALIFORNIA FISH AND GAME LA English DT Article DE clams; Humboldt Bay; historical survey; harvest estimates; bootstrap ID EELGRASS AB A sport clam survey, conducted January through December 2008 in Humboldt Bay, California, was the continuation of a creel-type survey conducted by the California Department of Fish and Game from 1975 through 1989. Surveys were conducted on low tides in the south arm of Humboldt Bay. Data were collected on clammer effort and catch resulting in bootstrapped estimates of the number of clammer trips (clammer-days) per year, catch per unit effort, total catch by species, and spatial distribution of effort within the bay. The survey revealed an important shift in harvested clam species composition, a decrease in harvest level, and methods of harvest apparently unique to Humboldt Bay. C1 [Mcveigh, Brooke A. B.] Calif Dept Fish & Game, Eureka, CA 95501 USA. [Geibel, John J.] Calif Dept Fish & Game, Belmont, CA 94002 USA. [Kalvass, Peter E.] Calif Dept Fish & Game, Ft Bragg, CA 95437 USA. RP Mcveigh, BAB (reprint author), Calif Dept Fish & Game, 619 2nd St, Eureka, CA 95501 USA. EM pkalvass@dfg.ca.gov NR 12 TC 0 Z9 0 U1 0 U2 1 PU CALIFORNIA FISH AND GAME EDITOR PI SACRAMENTO PA 1416 NINTH ST, SACRAMENTO, CA 95814 USA SN 0008-1078 J9 CALIF FISH GAME JI Calif. Fish Game PD FAL PY 2010 VL 96 IS 4 BP 245 EP 255 PG 11 WC Fisheries; Zoology SC Fisheries; Zoology GA 757BZ UT WOS:000290060300003 ER PT J AU Deichert, CL AF Deichert, Christian L. TI IS GERMANY THE NEW CANADA? ONE AMERICAN DESERTER'S REQUEST FOR GERMAN ASYLUM SO MILITARY LAW REVIEW LA English DT Article C1 [Deichert, Christian L.] USA, Washington, DC USA. RP Deichert, CL (reprint author), USAF, Judge Advocate Gen Sch, Maxwell AFB, AL USA. NR 43 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2010 VL 205 BP 94 EP 116 PG 23 WC Law SC Government & Law GA 736TV UT WOS:000288518800002 ER PT J AU Hill, JT AF Hill, James T. TI ACHIEVING TRANSPARENCY IN THE MILITARY PANEL SELECTION PROCESS WITH THE PRESELECTION METHOD SO MILITARY LAW REVIEW LA English DT Article ID MEMBERS C1 [Hill, James T.] USA, Washington, DC USA. RP Hill, JT (reprint author), 2d Brigade, Armored Div 1, Ft Bliss, TX USA. NR 22 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2010 VL 205 BP 117 EP + PG 33 WC Law SC Government & Law GA 736TV UT WOS:000288518800003 ER PT J AU Saito, A Epureanu, BI Castanier, MP Pierre, C AF Saito, Akira Epureanu, Bogdan I. Castanier, Matthew P. Pierre, Christophe TI Node Sampling for Nonlinear Vibration Analysis of Structures with Intermittent Contact SO AIAA JOURNAL LA English DT Article; Proceedings Paper CT AIAA/ASME/ASCE/AHS/ASC 50th Structures, Structural Dynamics and Materials Conference CY MAY 02-07, 2009 CL Palm Springs, CA SP Amer Inst Aeronaut & Astronaut, ASME, ASCE, AHS, ASC ID EIGENVALUE PROBLEMS; NATURAL FREQUENCY; SELECTION METHOD; ORDER REDUCTION; DYNAMIC-SYSTEMS; MODEL-REDUCTION; CONDENSATION; FREEDOM; IDENTIFICATION; LOCATIONS AB In this paper, a node sampling methodology for nonlinear vibration problems of elastic structures involving intermittent contact is proposed. Of particular interest is a vibration problem of platelike elastic structures with a crack, with a large number of degrees of freedom involved on the crack sill-faces. Because of the localized nature of such nonlinearity, the number of degrees of freedom on the surfaces greatly affects the computational time of the analysis. Therefore, reducing the number of degrees of freedom on the crack surfaces without significantly sacrificing the accuracy of the results is a critical issue for conducting vibration analysis of such structures in a reasonable amount of time. The focus is placed on the development of an efficient algorithm to select a set of nodes on the crack surfaces, where nonlinear boundary conditions are imposed. The method is developed, based on a procedure for selecting master degrees of freedom for Guyan reduction. The accuracy, efficiency, and optimality of the method are discussed in detail and compared with those aspects of previous methods. The advantages of the new method are demonstrated in terms of the accuracy of the frequency response and the resonant frequencies. C1 [Saito, Akira; Epureanu, Bogdan I.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Castanier, Matthew P.] US Army Tank Automot Res, Dev & Engn Ctr, Business Res Grp, Warren, MI 48397 USA. [Pierre, Christophe] McGill Univ, Fac Engn, Montreal, PQ H3A 2K6, Canada. RP Saito, A (reprint author), Toyota Cent Res & Dev Labs Inc, Vehicle Mech Lab, Vehicle & Biomech Syst Div, Aichi 4801192, Japan. RI Saito, Akira/P-7335-2015; OI Saito, Akira/0000-0001-8102-3754; Castanier, Matthew/0000-0002-3646-382X NR 44 TC 6 Z9 6 U1 4 U2 11 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 J9 AIAA J JI AIAA J. PD SEP PY 2010 VL 48 IS 9 BP 1903 EP 1915 DI 10.2514/1.J050061 PG 13 WC Engineering, Aerospace SC Engineering GA 646NK UT WOS:000281548100005 ER PT J AU El-Guindy, NBD Kovacs, EJ De Witte, P Spies, C Littleton, JM de Villiers, WJS Lott, AJ Plackett, TP Lanzke, N Meadows, GG AF El-Guindy, Nympha B. D'Souza Kovacs, Elizabeth J. De Witte, Philippe Spies, Claudia Littleton, John M. de Villiers, Willem J. S. Lott, Amanda J. Plackett, Timothy P. Lanzke, Nadine Meadows, Gary G. TI Laboratory Models Available to Study Alcohol-Induced Organ Damage and Immune Variations: Choosing the Appropriate Model SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE Animal Models; Acute and Chronic Alcohol Abuse; Immune Defects; Organ Damage ID KILLER-CELL-ACTIVITY; CHRONIC ETHANOL INGESTION; INDUCED LIVER-INJURY; RATS FED ETHANOL; INDUCED NEUTROPHIL CHEMOATTRACTANT; INTESTINAL BACTERIAL-GROWTH; MYOCARDIAL OXIDATIVE STRESS; NITRIC-OXIDE SYNTHASE; TUMOR NECROSIS FACTOR; INBRED MOUSE STRAINS AB The morbidity and mortality resulting from alcohol-related diseases globally impose a substantive cost to society. To minimize the financial burden on society and improve the quality of life for individuals suffering from the ill effects of alcohol abuse, substantial research in the alcohol field is focused on understanding the mechanisms by which alcohol-related diseases develop and progress. Since ethical concerns and inherent difficulties limit the amount of alcohol abuse research that can be performed in humans, most studies are performed in laboratory animals. This article summarizes the various laboratory models of alcohol abuse that are currently available and are used to study the mechanisms by which alcohol abuse induces organ damage and immune defects. The strengths and weaknesses of each of the models are discussed. Integrated into the review are the presentations that were made in the symposium "Methods of Ethanol Application in Alcohol Model-How Long is Long Enough" at the joint 2008 Research Society on Alcoholism (RSA) and International Society for Biomedical Research on Alcoholism (ISBRA) meeting, Washington, DC, emphasizing the importance not only of selecting the most appropriate laboratory alcohol model to address the specific goals of a project but also of ensuring that the findings can be extrapolated to alcohol-induced diseases in humans. C1 [El-Guindy, Nympha B. D'Souza; de Villiers, Willem J. S.; Lott, Amanda J.] Univ Kentucky, Div Digest Dis, Dept Internal Med, Lexington, KY 40536 USA. [El-Guindy, Nympha B. D'Souza; de Villiers, Willem J. S.; Lott, Amanda J.] Vet Affairs Med Ctr, Lexington, KY USA. [Kovacs, Elizabeth J.] Loyola Univ, Med Ctr, Dept Surg, Maywood, IL 60153 USA. [Kovacs, Elizabeth J.] Loyola Univ, Med Ctr, Alcohol Res Program, Maywood, IL 60153 USA. [De Witte, Philippe] Univ Catholique Louvan, Louvain, Belgium. [Spies, Claudia; Lanzke, Nadine] Charite, Dept Anaesthesiol & Intens Care Med, D-13353 Berlin, Germany. [Littleton, John M.] Univ Kentucky, Kentucky Tobacco Res & Dev Ctr, Lexington, KY USA. [Plackett, Timothy P.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Meadows, Gary G.] Washington State Univ, Coll Pharm, Chron Illness Res Ctr, Pullman, WA 99164 USA. [Meadows, Gary G.] Washington State Univ, Coll Pharm, Dept Pharmaceut Sci, Pullman, WA 99164 USA. RP El-Guindy, NBD (reprint author), Univ Kentucky, Div Digest Dis, Dept Internal Med, Lexington, KY 40536 USA. EM nbdsou0@uky.edu FU National Institutes of Health, NIAAA [R01 AA013168]; NIAAA [R01 AA012034, R01 AA07293, K05 AA017149]; Illinois Excellence in Academic Medicine Grant; Ralph and Marian C. Falk Research Trust; ERAB [EA0312] FX This work was supported by National Institutes of Health, NIAAA grant R01 AA013168 (D'Souza El-Guindy); NIAAA R01 AA012034, Illinois Excellence in Academic Medicine Grant, and Ralph and Marian C. Falk Research Trust (Kovacs); NIAAA R01 AA07293 and K05 AA017149 (Meadows); ERAB EA0312 (De Witte), and, in part, with resources and the use of Lexington VAMC facilities (D'Souza El-Guindy). NR 315 TC 23 Z9 23 U1 4 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD SEP PY 2010 VL 34 IS 9 BP 1489 EP 1511 DI 10.1111/j.1530-0277.2010.01234.x PG 23 WC Substance Abuse SC Substance Abuse GA 642NC UT WOS:000281220700001 ER PT J AU Gauer, R AF Gauer, Robert TI Hyperlipidemia Treatment in Children: The Younger, the Better SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material ID CARDIOVASCULAR RISK-FACTORS; FAMILIAL HYPERCHOLESTEROLEMIA; STATIN THERAPY; HEART-DISEASE; ATHEROSCLEROSIS; ASSOCIATION; ADOLESCENTS; CHILDHOOD; NUTRITION; HEALTH C1 Womack Army Med Ctr Family Med Residency, Ft Bragg, NC USA. RP Gauer, R (reprint author), Womack Army Med Ctr Family Med Residency, Ft Bragg, NC USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 1 PY 2010 VL 82 IS 5 BP 460 EP + PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 647JU UT WOS:000281615600004 PM 20822078 ER PT J AU Cheuvront, SN Ely, BR Kenefick, RW Sawka, MN AF Cheuvront, Samuel N. Ely, Brett R. Kenefick, Robert W. Sawka, Michael N. TI Biological variation and diagnostic accuracy of dehydration assessment markers SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID HYDRATION STATUS; CLINICAL-CHEMISTRY; SERUM OSMOLALITY; OLDER-ADULTS; BODY-WATER; SHORT-TERM; EXERCISE; INDEXES; PLASMA; INDIVIDUALITY AB Background: Well-recognized markers for static (one time) or dynamic (monitoring over time) dehydration assessment have not been rigorously tested for their usefulness in clinical, military, and sports medicine communities. Objective: This study evaluated the components of biological variation and the accuracy of potential markers in plasma, urine, saliva, and body mass (B(m)) for static and dynamic dehydration assessment. Design: We studied 18 healthy volunteers (13 men and 5 women) while carefully controlling hydration and numerous preanalytic factors. Biological variation was determined over 3 consecutive days by using published methods. Atypical values based on statistical deviations from a homeostatic set point were examined. Measured deviations in body fluid were produced by using a separate, prospective dehydration experiment and evaluated by receiver operating characteristic (ROC) analysis to quantify diagnostic accuracy. Results: All dehydration markers displayed substantial individuality and one-half of the dehydration markers displayed marked heterogeneity of intraindividual variation. Decision levels for all dehydration markers were within one SD of the ROC criterion values, and most levels were nearly identical to the prospective group means after volunteers were dehydrated by 1.8-7.0% of B(m). However, only plasma osmolality (P(osm)) showed statistical promise for use in the static dehydration assessment. A diagnostic decision level of 301 +/- 5 mmol/kg was proposed. Reference change values of 9 mmol/kg (P(osm)), 0.010 [urine specific gravity (U(sg))], and 2.5% change in B(m) were also statistically valid for dynamic dehydration assessment at the 95% probability level. Conclusions: P(osm) is the only useful marker for static dehydration assessment. P(osm), U(sg), and B(m) are valid markers in the setting of dynamic dehydration assessment. Am J Clin Nutr 2010;92:565-73. C1 [Cheuvront, Samuel N.; Ely, Brett R.; Kenefick, Robert W.; Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), USA, Thermal & Mt Med Div, Environm Med Res Inst, Kansas St, Natick, MA 01760 USA. EM samuel.n.cheuvront@us.army.mil FU US Army Medical Research and Materiel Command FX Supported by the US Army Medical Research and Materiel Command. NR 53 TC 102 Z9 102 U1 3 U2 30 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD SEP PY 2010 VL 92 IS 3 BP 565 EP 573 DI 10.3945/ajcn.2010.29490 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 644PC UT WOS:000281390800013 PM 20631205 ER PT J AU Garlie, TN Obusek, JP Corner, BD Zambraski, EJ AF Garlie, Todd N. Obusek, John P. Corner, Brian D. Zambraski, Edward J. TI Comparison of Body Fat Estimates Using 3D Digital Laser Scans, Direct Manual Anthropometry, and DXA in Men SO AMERICAN JOURNAL OF HUMAN BIOLOGY LA English DT Article ID X-RAY ABSORPTIOMETRY; SURFACE-AREA; AGREEMENT; OBESITY AB Objectives: The purpose of this study was to assess the feasibility of utilizing three dimensional whole body laser surface scanning (3DS) to obtain specific anthropometric measurements to estimate percent body fat (BF) Methods: Percent BF estimates from 37 male volunteers, of age 18-62 yr, were determined by inputting manual anthropometric (MA) and 3DS anthropometric measurements into the current Army BF prediction equation for males. The results were compared with each other and to BF values from Dual Energy X-ray Absorptiometry (DXA), employed as a reference method. Results: Mean percent BF estimates (+/-SD) derived from MA, 3DS and from DXA were 18 4(+/-3.8), 18.8(+/-3.9), and 18.9(+/-4 7), respectively. Analysis of Variance tests revealed no statistical difference between the mean values. Correlation analysis comparing MA and 3DS derived percent BF estimates to each other and to those measured by DXA revealed moderate to strong Pearson correlation coefficients (r), small to moderate standard errors of the estimate (SEE), and were statistically significant (p < 0 05) Conclusions: Correlation coefficients and SEE results for this sample were. (1) DXA vs 3DS; r = 0 74, SEE = 3 2, (2) MA vs DXA; r = 0.82, SEE = 2 8, and (3) MA vs 3DS; r = 0.96, SEE = 1.0. Lin's concordance analysis, including Bland-Altman limits of agreement (LOA), revealed statistically significant measurement agreement among the three measurement modalities (p < 0 05) The application of 3DS scanning to estimate percent BF from commonly used anthropometric measurements are in close agreement with BF estimates derived from analogous MA measurements and from DXA scanning. Am J. Hum. Biol 22:695-701, 2010. Published 2010 Wiley-Liss, Inc(dagger) C1 [Garlie, Todd N.] USA, Ergon Grp, WarSTAR Directorate, NSRDEC, Natick, MA 01760 USA. [Zambraski, Edward J.] USA, Mil Performance Div, Inst Environm Med, NSSC, Natick, MA 01760 USA. RP Garlie, TN (reprint author), USA, Ergon Grp, WarSTAR Directorate, NSRDEC, 45 Kansas St, Natick, MA 01760 USA. FU Department of the Army FX Funding for this study was provided by the Department of the Army. We would like to thank the Soldier and civilian volunteers whose willingness to participate made this study possible. NR 58 TC 6 Z9 8 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1042-0533 EI 1520-6300 J9 AM J HUM BIOL JI Am. J. Hum. Biol. PD SEP-OCT PY 2010 VL 22 IS 5 BP 695 EP 701 DI 10.1002/ajhb.21069 PG 7 WC Anthropology; Biology SC Anthropology; Life Sciences & Biomedicine - Other Topics GA 645UY UT WOS:000281492900018 PM 20737619 ER PT J AU Parkinson, MD Ahluwalia, JS Shih, DC Barry, MA Schechter, CB AF Parkinson, Michael D. Ahluwalia, Jaspal S. Shih, David C. Barry, Michael A. Schechter, Clyde B. CA ACPM Aspirin Expert Panel TI Advancing Aspirin Utilization: A Review of Clinical and Systems-Based Interventions SO AMERICAN JOURNAL OF MEDICAL QUALITY LA English DT Review DE clinical preventive services; aspirin use; prevention systems cascade; patient-clinical dyad; microsystem ID CONTINUING MEDICAL-EDUCATION; PREVENTIVE SERVICE DELIVERY; FACTOR SURVEILLANCE SYSTEM; IMPROVING PRIMARY-CARE; COLLABORATIVE METAANALYSIS; SECONDARY PREVENTION; ECONOMIC INCENTIVES; RANDOMIZED-TRIALS; CHRONIC ILLNESS; OFFICE SYSTEMS AB Underuse of clinical preventive services (CPS) such as low-dose aspirin therapy leads to tens of thousands of preventable deaths per year. The authors examined the current literature related to delivery of CPS and then provided the results to a preventive medicine expert panel who identified best practices to improve aspirin counseling and use. An exploratory literature search was conducted in PubMed using keywords associated with preventive health interventions. The review included articles published between January 2000 and March 2009. More than 200 articles were identified for review, and 35 met inclusion criteria. Interventions that increased patient-provider contact and physician interactive educational programs were most likely to improve delivery of CPS. The expert panel recommended a prevention systems cascade of reinforcing strategies and tools to maximize appropriate aspirin use. This model emphasizes important interrelationships of clinical practice settings and how they affect aspirin use. C1 [Parkinson, Michael D.; Shih, David C.; Barry, Michael A.] Amer Coll Prevent Med, Pittsburgh, PA USA. [Ahluwalia, Jaspal S.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Schechter, Clyde B.] Albert Einstein Coll Med, Bronx, NY 10467 USA. RP Ahluwalia, JS (reprint author), 503 Robert Grant Ave 2A31, Silver Spring, MD 20910 USA. EM jahluwal@jhsph.edu FU Bayer HealthCare FX The authors disclosed receipt of the following financial support for the research and/or authorship of this article: This work was supported by an educational grant from Bayer HealthCare. The sponsors played no role in the conduct of the research or preparation of the manuscript. NR 51 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1062-8606 J9 AM J MED QUAL JI Am. J. Med. Qual. PD SEP-OCT PY 2010 VL 25 IS 5 BP 351 EP 358 DI 10.1177/1062860610366032 PG 8 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 686LA UT WOS:000284696600005 PM 20501864 ER PT J AU Park, AJ Barber, MD Bent, AE Dooley, YT Dancz, C Sutkin, G Jelovsek, JE AF Park, Amy J. Barber, Matthew D. Bent, Alfred E. Dooley, Yashika T. Dancz, Christina Sutkin, Gary Jelovsek, J. Eric TI Assessment of intraoperative judgment during gynecologic surgery using the Script Concordance Test SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 30th Annual Meeting of the American-Urogynecologic-Society CY SEP 24-26, 2009 CL Hollywood, FL SP Amer Urogynecol Soc DE clinical competence; decision-making; education (medical, graduate); educational measurement; intraoperative judgment; operative/education/psychology; problem-based learning; surgical procedures ID DIAGNOSTIC KNOWLEDGE AB OBJECTIVE: We sought to develop a valid, reliable assessment of intraoperative judgment by residents during gynecologic surgery based on Script Concordance Theory. STUDY DESIGN: This was a multicenter prospective study involving 5 obstetrics and gynecology residency programs. Surgeons from each site generated case scenarios based on common gynecologic procedures. Construct validity was evaluated by correlating scores to training level, in-service examinations, and surgical skill and experience using a Global Rating Scale of Operative Performance and case volumes. RESULTS: A final test that included 42 case scenarios was administered to 75 residents. Internal consistency (Cronbach alpha = 0.73) and test-retest reliability (Lin correlation coefficient = 0.76) were good. There were significant differences between test scores and training levels (P = .002) and test scores correlated with in-service examination scores (r = 0.38; P = .001). There was no association between test scores and total number of cases or technical skills. CONCLUSION: The Script Concordance Test appears to be a reliable, valid assessment tool for intraoperative decision-making during gynecologic surgery. C1 [Park, Amy J.; Barber, Matthew D.; Jelovsek, J. Eric] Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA. [Bent, Alfred E.] Dalhousie Univ, Dept Obstet & Gynecol, IWK Hlth Ctr, Halifax, NS, Canada. [Dooley, Yashika T.] Brooke Army Med Ctr, Dept Obstet & Gynecol, San Antonio, TX USA. [Dancz, Christina] Univ So Calif, Keck Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90033 USA. [Sutkin, Gary] Univ Pittsburgh, Magee Womens Hosp, Dept Obstet & Gynecol, Pittsburgh, PA 15213 USA. RP Park, AJ (reprint author), Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA. NR 13 TC 5 Z9 5 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD SEP PY 2010 VL 203 IS 3 AR 240.e1 DI 10.1016/j.ajog.2010.04.010 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 647FH UT WOS:000281602700022 PM 20494330 ER PT J AU Veerappan, GR Ally, MR Choi, JHR Pak, JS Maydonovitch, C Wong, RKH AF Veerappan, Ganesh R. Ally, Mazer R. Choi, Jong-ho R. Pak, Jennifer S. Maydonovitch, Corinne Wong, Roy K. H. TI Extracolonic Findings on CT Colonography Increases Yield of Colorectal Cancer Screening SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE colon cancer; CT colonography; extracolonic findings; high-risk lesions; screening ID COMPUTED TOMOGRAPHIC COLONOGRAPHY; VIRTUAL COLONOSCOPY; ECONOMIC-IMPACT; POPULATION; PREVALENCE; POLYPS; ABNORMALITIES; FREQUENCY; NEOPLASMS AB OBJECTIVE. The purpose of this study is to evaluate the impact of extracolonic findings when screening is undertaken by CT colonography (CTC). MATERIALS AND Met hods. We performed a retrospective cohort study of patients completing a screening CTC from August 2003 to June 2006 at Walter Reed Army Medical Center. Extracolonic findings were categorized using a CTC reporting and data system that classifies findings as highly significant, likely significant, and insignificant. All final diagnoses, surgeries, malignancies, and costs of diagnostic radiology procedures were calculated for each category. RESULTS. Of 2,277 patients (mean +/- SD age, 59 +/- 11 years; 60% white; 56% male) undergoing CTC, extracolonic findings were identified in 1,037 (46%) patients, with 787 (34.5%) insignificant and 240 (11.0%) significant findings. Evaluation of significant findings generated 280 radiology procedures and 19 surgeries over a mean follow-up time of 19 +/- 10 months. The total cost of the radiology studies was $113,179; the studies added approximately $50 extra per patient. Seven high-risk lesions were identified (six extracolonic malignancies and one large aortic aneurysm) in patients with significant findings. CTC also identified six intracolonic malignancies and three adenomas with high-grade dysplasia. When considering extracolonic findings, CTC increased the odds of identifying high-risk lesions by 78% (nine intracolonic lesions vs 16 intracolonic plus extracolonic lesions; p = 0.0156). Of the 16 intracolonic and extracolonic high-risk lesions, 11 (69%) underwent curative resection, and 5 of 11 (44.4%) were extracolonic. CONCLUSION. CTC increased the odds of identifying high-risk lesions by 78%. CTC should be considered as an alternative to optical colonoscopy for colorectal cancer screening or as a onetime procedure to identify significant treatable intracolonic and extracolonic lesions. C1 [Veerappan, Ganesh R.; Ally, Mazer R.; Pak, Jennifer S.; Maydonovitch, Corinne; Wong, Roy K. H.] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. [Veerappan, Ganesh R.; Ally, Mazer R.; Wong, Roy K. H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Choi, Jong-ho R.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Veerappan, GR (reprint author), Walter Reed Army Med Ctr, Gastroenterol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM Ganesh.veerappan@us.army.mil NR 27 TC 37 Z9 38 U1 1 U2 5 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2010 VL 195 IS 3 BP 677 EP 686 DI 10.2214/AJR.09.3779 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 642CI UT WOS:000281180500021 PM 20729446 ER PT J AU Knapik, JJ Trone, DW Swedler, DI Villasenor, A Bullock, SH Schmied, E Bockelman, T Han, P Jones, BH AF Knapik, Joseph J. Trone, Daniel W. Swedler, David I. Villasenor, Adriana Bullock, Steve H. Schmied, Emily Bockelman, Timothy Han, Peggy Jones, Bruce H. TI Injury Reduction Effectiveness of Assigning Running Shoes Based on Plantar Shape in Marine Corps Basic Training SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE physical fitness; physical activity; tobacco use; prior injury; demographics; menstrual dysfunction ID LOWER-EXTREMITY INJURY; MEDICAL SURVEILLANCE; US NAVY; MILITARY; EPIDEMIOLOGY; PREVENTION; RECOMMENDATIONS; RECRUITS; RATES; ARMY AB Background: Shoe manufacturers market motion control, stability, and cushioned shoes for plantar shapes defined as low, normal, and high, respectively. This assignment procedure is presumed to reduce injuries by compensating for differences in running mechanics. Hypothesis: Assigning running shoes based on plantar shape will not reduce injury risk in Marine Corps basic training. Study Design: Randomized controlled clinical trial; Level of evidence, 1. Methods: After foot examinations, Marine Corps recruits in an experimental group (E: 408 men, 314 women) were provided motion control, stability, or cushioned shoes for plantar shapes indicative of low, medium, or high arches, respectively. A control group (C: 432 men, 257 women) received a stability shoe regardless of plantar shape. Injuries during the 12 weeks of training were determined from outpatient visits obtained from the Defense Medical Surveillance System. Other known injury risk factors (eg, fitness, smoking, prior physical activity) were obtained from a questionnaire, existing databases, or the training units. Results: Cox regression indicated little difference in injury risk between the E and C groups among men (hazard ratio [E/C] = 1.01; 95% confidence interval, 0.82-1.24) or women (hazard ratio [E/C] = 0.88; 95% confidence interval, 0.70-1.10). Conclusion: This prospective study demonstrated that assigning shoes based on the shape of the plantar foot surface had little influence on injuries even after considering other injury risk factors. C1 [Knapik, Joseph J.; Bullock, Steve H.; Jones, Bruce H.] USA, Directorate Epidemiol & Dis Surveillance, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Trone, Daniel W.; Villasenor, Adriana; Schmied, Emily; Han, Peggy] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Swedler, David I.] Johns Hopkins Univ, Baltimore, MD USA. [Bockelman, Timothy] Marine Corps Recruit Depot, Parris Isl, SC USA. RP Knapik, JJ (reprint author), USA, Directorate Epidemiol & Dis Surveillance, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@us.army.mil FU Naval Health Research Center, Work Unit [60626] FX This research was supported by the Naval Health Research Center, Work Unit No. 60626. We express our appreciation to the following members of our research team from the Naval Health Research Center in San Diego, California: Carol Macera, Mitchell Rauh, and Richard Shaffer. Additional thanks are due to James Reading from MCRD, San Diego, California. NR 31 TC 35 Z9 35 U1 1 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP PY 2010 VL 38 IS 9 BP 1759 EP 1767 DI 10.1177/0363546510369548 PG 9 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 644ZD UT WOS:000281419800003 PM 20576837 ER PT J AU Woodring, JV Ogutu, B Schnabel, D Waitumbi, JN Olsen, CH Walsh, DS Heppner, DG Polhemus, ME AF Woodring, Joseph V. Ogutu, Bernhards Schnabel, David Waitumbi, John N. Olsen, Cara H. Walsh, Douglas S. Heppner, D. Gray, Jr. Polhemus, Mark E. TI Evaluation of Recurrent Parasitemia after Artemether-Lumefantrine Treatment for Uncomplicated Malaria in Children in Western Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; ARTEMISININ COMBINATION THERAPIES; SULFADOXINE-PYRIMETHAMINE; YOUNG-CHILDREN; 6-DOSE REGIMEN; EFFICACY; RESISTANCE; DISEASE; SAFETY; TRIAL AB From April 2005 to April 2006, a phase 2 malaria vaccine trial in Kenya enrolled 400 children aged 12-47 months. Each received mixed supervised and unsupervised artemether-lumefantrine for uncomplicated malaria. using a standard six-dose regimen, by weight. Children were followed for detection of parasitemia and clinical malaria A median of two negative malaria blood films occurred during every recurrent parasitemia (RP) episode, suggesting reinfection over late recrudescence Median time to RP after starting artemether-lumefantrine was 37 days (36-38) Of 2.020 evaluable artemether-lumefantrine treatments, there were no RPs in 99% by day 14, 71% by day 28, and 41% by day 42 By World Health Organization standards. 71% of treatment courses had adequate responses Although recrudescence in some cannot be ruled out, our cohort had a shorter median time to RP compared with other artemether-lumefantrine treatment studies This underscores patient counseling on completing all treatment doses for optimal protection from RP C1 [Woodring, Joseph V.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Ogutu, Bernhards; Waitumbi, John N.] USA, Med Res Unit Kenya, Kenya Med Res Inst, Kisumu, Kenya. RP Woodring, JV (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RI Woodring, Joseph/G-1470-2013 FU US Department of Defense Global Emerging Infections Surveillance and Response System (GEIS); Malaria Vaccine Initiative at Program for Appropriate Technology in Health (PATH); US Agency for International Development; Military Infectious Diseases Research Program FX This study was funded by the US Department of Defense Global Emerging Infections Surveillance and Response System (GEIS), the Malaria Vaccine Initiative at Program for Appropriate Technology in Health (PATH), the US Agency for International Development, and the Military Infectious Diseases Research Program NR 27 TC 5 Z9 5 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2010 VL 83 IS 3 BP 458 EP 464 DI 10.4269/ajtmh.2010.09-0403 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 645SZ UT WOS:000281487800005 PM 20810804 ER PT J AU Lu, F Lim, CS Nam, DH Kim, K Lin, K Kim, TS Lee, HW Chen, JH Wang, Y Sattabongkot, J Han, ET AF Lu, Feng Lim, Chae Seung Nam, Deok Hwa Kim, Kwonkee Lin, Khin Kim, Tong-Soo Lee, Hyeong-Woo Chen, Jun-Hu Wang, Yue Sattabongkot, Jetsumon Han, Eun-Taek TI Mutations in the Antifolate-Resistance-Associated Genes Dihydrofolate Reductase and Dihydropteroate Synthase in Plasmodium vivax Isolates from Malaria-Endemic Countries SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID AMINO-ACID MUTATIONS; REPUBLIC-OF-KOREA; SULFADOXINE-PYRIMETHAMINE; CONFERRING MUTATIONS; FALCIPARUM-MALARIA; MOLECULAR MARKERS; SYNTHETASE GENE; IN-VIVO; CHLOROQUINE; MYANMAR AB Parasite dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) are known target enzymes of antifolate drugs used for the treatment and prophylaxis of persons with malaria We sequenced the Plasmodium vivax dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) genes to examine the prevalence and extent of point mutations in isolates from malaria-endemic countries Double mutations (S58R and S117N) or quadruple mutations (F57L/I, S58R, T61M, and S117T) in the pvdhfr gene were found m isolates from Thailand (96.4%) and Myanmar (71.4%), but in only one isolate (10%) from Korea. where sulfadoxine-pyrimethamine has never been used The pvdhfr point mutations correlated strongly with the pvdhps point mutations and ranged from single to triple mutations (S382A, A383G, and A553G), among isolates from Thailand. Myanmar, and Korea These findings suggests that the prevalence of mutations in pvdhfr and pvdhps in P vivax isolates from different malaria-endemic countries is associated with selection pressure imposed by sulfadoxine-pyrimethamine C1 [Han, Eun-Taek] Kangwon Natl Univ, Dept Parasitol, Coll Med, Chunchon 200701, Gangwon Do, South Korea. Korea Univ, Coll Med, Dept Lab Med, Seoul 136705, South Korea. Jiangsu Inst Parasit Dis, Wuxi, Peoples R China. Gachon Univ, Cheorwon Gil Hosp, Dept Internal Med, Cheorwon, South Korea. Minist Hlth, Dept Hlth, Vector Borne Dis Control Project, Mandalay, Myanmar. Inha Univ, Sch Med, Dept Parasitol, Inchon, South Korea. Korea Ctr Dis Control & Prevent, Natl Inst Hlth, Dept Malaria & Parasite Dis, Seoul, South Korea. Zhejiang Acad Med Sci, Hangzhou, Peoples R China. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Han, ET (reprint author), Kangwon Natl Univ, Dept Parasitol, Coll Med, Hyoja2 Dong, Chunchon 200701, Gangwon Do, South Korea. FU Korean Government [KRF-2008-314-E00075] FX This study was supported by a National Research Foundation of Korea grant funded by the Korean Government (KRF-2008-314-E00075) NR 34 TC 21 Z9 21 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2010 VL 83 IS 3 BP 474 EP 479 DI 10.4269/ajtmh.2010.10-0004 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 645SZ UT WOS:000281487800007 PM 20810806 ER PT J AU Brochero, H Li, C Wilkerson, R Conn, JE Ruiz-Garcia, M AF Brochero, Helena Li, Cong Wilkerson, Richard Conn, Jan E. Ruiz-Garcia, Manuel TI Genetic Structure of Anopheles (Nyssorhynchus) marajoara (Diptera: Culicidae) in Colombia SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HUMAN-POPULATION EXPANSION; AEDES-AEGYPTI POPULATIONS; MITOCHONDRIAL-DNA; ALBITARSIS COMPLEX; SOUTH-AMERICA; MICROSATELLITE LOCI; MOSQUITOS DIPTERA; CAT POPULATIONS; F-STATISTICS; RARE ALLELES AB Five Anopheles marajoara Galvao and Damasceno populations. representing diverse ecological conditions. were sampled throughout Colombia and analyzed using nine hypervariable DNA microsatellite loci The overall genetic diversity (H = 0 58) was lower than that determined for some Brazilian populations using the same markers The Caqueta population (Colombia) had the lowest gene diversity (H = 0.48), and it was the only population at Hardy-Wemberg equilibrium. Hardy-Wemberg disequilibrium in the remaining four populations was probably caused by the Wahlund effect. The assignment analyses showed two incompletely isolated gene pools separated by the Eastern Andean cordillera However. other possible geographical barriers (rivers and other mountains) did not play any role in the moderate genetic heterogeneity found among these populations (F(SI) = 0 069) These results are noteworthy. because this species is a putative malaria vector in Colombia. C1 [Ruiz-Garcia, Manuel] Pontificia Univ Javeriana, Fac Ciencias, Dept Biol, Lab Genet Poblac Mol Biol Evolut,Unidad Genet, Bogota, DC, Colombia. [Brochero, Helena] Univ Nacl Colombia, Fac Agron, Bogota, DC, Colombia. [Li, Cong; Wilkerson, Richard] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Conn, Jan E.] NYSDOH, Wadsworth Ctr, Griffin Lab, Slinger Lands, NY USA. RP Ruiz-Garcia, M (reprint author), Pontificia Univ Javeriana, Fac Ciencias, Dept Biol, Lab Genet Poblac Mol Biol Evolut,Unidad Genet, Cra 7th 43-82, Bogota, DC, Colombia. OI Conn, Jan/0000-0002-5301-7020 FU Walter Reed Army Institute of Research; Colombian National Health Institute 13; National Institutes of Health [AI R0154139] FX The authors thank technical personnel from Health Department of Magdalena (Katiuska Atiza). Antioquia (Armando Galeano). Caqueta (Albeit Polania). Norte de Santander (Euhdes Pabon and Panfilo Lobo). and Meta (Luz Stella Buitrago) This research was performed with institutional support provided by both Walter Reed Army Institute of Research and the Colombian National Health Institute 13:until support was provided by National Institutes of Health Grant AI R0154139 to J E C and Colciencias to B Logistical support was obtained from the Pontificia Universidad Javeriana at Bogota DC, Colombia. to M R -G to early out the population genetics analyses and write the present manuscript NR 76 TC 8 Z9 8 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2010 VL 83 IS 3 BP 585 EP 595 DI 10.4269/ajtms.2010.09-0482 PG 11 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 645SZ UT WOS:000281487800026 PM 20810825 ER PT J AU Lundy, JB Hetz, K Chung, KK Renz, EM White, CE King, BT Huzar, T Wolf, SE Blackbourne, LH AF Lundy, Jonathan B. Hetz, Katherine Chung, Kevin K. Renz, Evan M. White, Christopher E. King, Booker T. Huzar, Todd Wolf, Steven E. Blackbourne, Lorne H. TI Outcomes with the Use of Recombinant Human Erythropoietin in Critically Ill Burn Patients SO AMERICAN SURGEON LA English DT Article; Proceedings Paper CT Annual Scientific Meeting and Postgraduate Course Program of the Southeastern-Surgical-Congress CY FEB 20-23, 2010 CL Savannah, GA ID CONTROLLED TRIAL; EFFICACY; ANEMIA; TRANSFUSION; MULTICENTER; CARE AB Recent data demonstrate a possible mortality benefit in traumatically injured patients when given subcutaneous recombinant human erythropoietin (rhEPO). The purpose of this report is to examine the effect of rhEPO on mortality and transfusion in burn patients. We conducted a review of burn patients (greater than 30% total body surface area, intensive care unit [ICU] days greater than 15) treated with 40,000u rhEPO over an 18-month period (January 2007 to July 2008). Matched historical controls were identified and a contemporaneous cohort of subjects not administered rhEPO was used for comparison (NrhEPO). Mortality, transfusions, ICU and hospital length of stay were assessed. A total of 105 patients were treated (25 rhEPO, 53 historical control group, 27 NrhEPO). Hospital transfusions (mean 13,704 +/- mL vs 13,308 +/- mL; P = 0.42) and mortality (29.6 vs 32.0%; P = 0.64) were similar. NrhEPO required more blood transfusions (13,308 mL vs 6,827 mL; P = 0.004). No difference in mortality for the rhEPO and NrhEPO (32.0 vs 22.2%; P = 0.43) was found. Thromboembolic complications were similar in all three groups. No effect was seen for rhEPO treatment on mortality or blood transfusion requirements in the severely burned. C1 [Lundy, Jonathan B.; Chung, Kevin K.; Renz, Evan M.; White, Christopher E.; King, Booker T.; Huzar, Todd; Wolf, Steven E.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Hetz, Katherine] Brooke Army Med Ctr, Dept Gen Surg, Ft Sam Houston, TX 78234 USA. [Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Lundy, JB (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Dr, Ft Sam Houston, TX 78234 USA. EM jlundy1313@yahoo.com OI Wolf, Steven/0000-0003-2972-3440 NR 18 TC 5 Z9 6 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD SEP PY 2010 VL 76 IS 9 BP 951 EP 956 PG 6 WC Surgery SC Surgery GA 643LD UT WOS:000281297000007 PM 20836341 ER PT J AU Isaacson, BM Stinstra, JG MacLeod, RS Pasquina, PF Bloebaum, RD AF Isaacson, Brad M. Stinstra, Jeroen G. MacLeod, Rob S. Pasquina, Paul F. Bloebaum, Roy D. TI Developing a Quantitative Measurement System for Assessing Heterotopic Ossification and Monitoring the Bioelectric Metrics from Electrically Induced Osseointegration in the Residual Limb of Service Members SO ANNALS OF BIOMEDICAL ENGINEERING LA English DT Article DE Electrical stimulation; Finite element analysis; Heterotopic ossification; Osseointegration; Residual limb; Service members ID TOTAL HIP-ARTHROPLASTY; HEAD-INJURED ADULTS; BONE-FORMATION; TRAUMATIC AMPUTEE; RISK-FACTORS; STIMULATION; FRACTURES; FIELD; FIBROBLASTS; PROSTHESES AB Poor prosthetic fit is often the result of heterotopic ossification (HO), a frequent problem following blast injuries for returning service members. Osseointegration technology offers an advantage for individuals with significant HO and poor socket tolerance by using direct skeletal attachment of a prosthesis to the distal residual limb, but remains limited due to prolonged post-operative rehabilitation regimens. Therefore, electrical stimulation has been proposed as a catalyst for expediting skeletal attachment and the bioelectric effects of HO were evaluated using finite element analysis in 11 servicemen with transfemoral amputations. Retrospective computed tomography (CT) scans provided accurate reconstructions, and volume conductor models demonstrated the variability in residual limb anatomy and necessity for patient-specific modeling to characterize electrical field variance if patients were to undergo a theoretical osseointegration of a prosthesis. In this investigation, the volume of HO was statistically significant when selecting the optimal potential difference for enhanced skeletal fixation, since higher HO volumes required increased voltages at the periprosthetic bone (p = 0.024, r = 0.670). Results from Spearman's rho correlations also indicated that the age of the subject and volume of HO were statistically significant and inversely proportional, in which younger service members had a higher frequency of HO (p = 0.041, r = -0.622). This study demonstrates that the volume of HO and age may affect the voltage threshold necessary to improve current osseointegration procedures. C1 [Isaacson, Brad M.; Bloebaum, Roy D.] US Dept Vet Affairs, Bone & Joint Res Lab, Salt Lake City, UT 84148 USA. [Pasquina, Paul F.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Isaacson, Brad M.; MacLeod, Rob S.; Bloebaum, Roy D.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA. [Bloebaum, Roy D.] Univ Utah, Dept Orthopaed, Salt Lake City, UT USA. [Bloebaum, Roy D.] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA. [Stinstra, Jeroen G.; MacLeod, Rob S.] Univ Utah, Sci Comp & Imagining Inst, Salt Lake City, UT USA. RP Bloebaum, RD (reprint author), US Dept Vet Affairs, Bone & Joint Res Lab 151F, Salt Lake City, UT 84148 USA. EM roy.bloebaum@hsc.utah.edu FU Veterans Affairs Office of Research and Development, Rehabilitation R&D Service, DVA SLC Health Care System, Salt Lake City, UT; Albert & Margaret Hofmann Chair and the Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT; Technology Commercialization Office, University of Utah, Salt Lake City, UT FX Gratitude is expressed to Gregory Stoddard for assistance and interpretation of statistical analysis, Darrell Swenson for support with image visualizations, and Gwenevere Shaw and Sharon Weeks for support with manuscript preparation. Grant & Financial Support: This material is based on study supported by the Veterans Affairs Office of Research and Development, Rehabilitation R&D Service, DVA SLC Health Care System, Salt Lake City, UT; the Albert & Margaret Hofmann Chair and the Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT; the Technology Commercialization Office, University of Utah, Salt Lake City, UT. Technical support for the simulations was provided by the Center for Integrative Biomedical Computing of Scientific Computing and Imaging Institute, and was made possible in part by software from the NIH/NCRR Center for Integrative Biomedical Computing, P41-RR12553-07. NR 56 TC 7 Z9 7 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-6964 J9 ANN BIOMED ENG JI Ann. Biomed. Eng. PD SEP PY 2010 VL 38 IS 9 BP 2968 EP 2978 DI 10.1007/s10439-010-0050-2 PG 11 WC Engineering, Biomedical SC Engineering GA 634PB UT WOS:000280594300016 PM 20458630 ER PT J AU Schmitz, GR Bruner, D Pitotti, R Olderog, C Livengood, T Williams, J Huebner, K Lightfoot, J Ritz, B Bates, C Schmitz, M Mete, M Deye, G AF Schmitz, Gillian R. Bruner, David Pitotti, Rebecca Olderog, Cameron Livengood, Timothy Williams, Justin Huebner, Kermit Lightfoot, Jeffrey Ritz, Brandon Bates, Christopher Schmitz, Matthew Mete, Mihriye Deye, Gregory TI Randomized Controlled Trial of Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscesses in Patients at Risk for Community-Associated Methicillin-Resistant Staphylococcus aureus Infection SO ANNALS OF EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT Conference on ACEP Research Forum Scientific Assembly CY OCT, 2009 CL Boston, MA ID SOFT-TISSUE INFECTIONS; OUTCOMES AB Study objective: Community-associated methicillin-resistant Staphylococcus aureus is now the leading cause of uncomplicated skin abscesses in the United States, and the role of antibiotics is controversial. We evaluate whether trimethoprim-sulfamethoxazole reduces the rate of treatment failures during the 7 days after incision and drainage and whether it reduces new lesion formation within 30 days. Methods: In this multicenter, double-blind, randomized, placebo-controlled trial, we randomized adults to oral trimethoprimsulfamethoxazole or placebo after uncomplicated abscess incision and drainage. Using emergency department rechecks at 2 and 7 days and telephone follow-up, we assessed treatment failure within 7 days, and using clinical follow-up, telephone follow-up, and medical record review, we recorded the development of new lesions within 30 days. Results: We randomized 212 patients, and 190 (90%) were available for 7-day follow-up. We observed a statistically similar incidence of treatment failure in patients receiving trimethoprim-sulfamethoxazole (15/88; 17%) versus placebo (27/102; 26%), difference 9%, 95% confidence interval 2% to 21%; P=.12. On 30-day follow-up (successful in 69% of patients), we observed fewer new lesions in the antibiotic (4/46; 9%) versus placebo (14/50; 28%) groups, difference 19%, 95% confidence interval 4% to 34%, P=.02. Conclusion: After the incision and drainage of uncomplicated abscesses in adults, treatment with trimethoprimsulfamethoxazole does not reduce treatment failure but may decrease the formation of subsequent lesions. [Ann Emerg Med. 2010;56:283-287.] C1 [Schmitz, Gillian R.] Washington Hosp Ctr, Dept Emergency Med, Washington, DC 20010 USA. [Bruner, David; Livengood, Timothy] Naval Med Ctr, Dept Emergency Med, Portsmouth, Hants, England. [Pitotti, Rebecca; Bates, Christopher] Wilford Hall USAF Med Ctr, Dept Emergency Med, Lackland AFB, TX 78236 USA. [Schmitz, Matthew] Wilford Hall USAF Med Ctr, Dept Orthopaed Surg, Lackland AFB, TX 78236 USA. [Olderog, Cameron; Livengood, Timothy; Williams, Justin] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Huebner, Kermit; Ritz, Brandon] Darnall Army Med Ctr, Dept Emergency Med, Ft Hood, TX USA. [Mete, Mihriye] Medstar Res Inst, Dept Epidemiol, Hyattsville, MD USA. [Mete, Mihriye] Medstar Res Inst, Dept Stat, Hyattsville, MD USA. [Deye, Gregory] Walter Reed Army Inst Res, Dept Clin Pharmacol, Silver Spring, MD USA. RP Schmitz, GR (reprint author), 714 Carpenter Rd, Alexandria, VA 22314 USA. EM GillianMD@gmail.com NR 11 TC 67 Z9 69 U1 0 U2 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2010 VL 56 IS 3 BP 283 EP 287 DI 10.1016/j.annemergmed.2010.03.002 PG 5 WC Emergency Medicine SC Emergency Medicine GA 645FX UT WOS:000281437900016 PM 20346539 ER PT J AU Lairet, JR Bebarta, V Lairet, K Kacprowicz, R Johnson, R Pitotti, R Bolleter, S Cowart, J Bush, A AF Lairet, J. R. Bebarta, V Lairet, K. Kacprowicz, R. Johnson, R. Pitotti, R. Bolleter, S. Cowart, J. Bush, A. TI Intraosseous Pressure infusion Comparison Using a Rapid Infusion Device and a Pressure Bag In a Swine Model SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Conference on American-College-of-Emergency-Physicians-Research-Forum CY SEP 28-29, 2010 CL Las Vegas, NV SP Amer Coll Emergency Phys Res Forum C1 Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Wright Patterson AFB, Wright Patterson AFB, OH USA. San Antonio AirLife, San Antonio, TX USA. 59th Clin Res Div, San Antonio, TX USA. RI Bebarta, Vikhyat/M-1513-2015 NR 0 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2010 VL 56 IS 3 SU S BP S26 EP S27 PG 2 WC Emergency Medicine SC Emergency Medicine GA 645FY UT WOS:000281438000078 ER PT J AU Rubal, BJ Gerhardt, RT Sartin, CW Neal, CL DeLorenzo, RA AF Rubal, B. J. Gerhardt, R. T. Sartin, C. W. Neal, C. L. DeLorenzo, R. A. TI Medullary Shear and Pressure Changes Associated With High Intraosseous Infusion Rates In an Isolated Hind Limb Preparation SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Conference on American-College-of-Emergency-Physicians-Research-Forum CY SEP 28-29, 2010 CL Las Vegas, NV SP Amer Coll Emergency Phys Res Forum C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 2010 VL 56 IS 3 SU S BP S113 EP S113 PG 1 WC Emergency Medicine SC Emergency Medicine GA 645FY UT WOS:000281438000348 ER PT J AU Bilchik, A Nissan, A Wainberg, Z Shen, P McCarter, M Protic, M Howard, R Elashoff, D Tyler, J Peoples, GE Stojadinovic, A AF Bilchik, Anton Nissan, Aviram Wainberg, Zev Shen, Perry McCarter, Martin Protic, Mladjan Howard, Robin Elashoff, David Tyler, Josh Peoples, George E. Stojadinovic, Alexander TI Surgical Quality and Nodal Ultrastaging Is Associated With Long-Term Disease-Free Survival in Early Colorectal Cancer An Analysis of 2 International Multicenter Prospective Trials SO ANNALS OF SURGERY LA English DT Article; Proceedings Paper CT 130th Annual Meeting of the American-Surgical-Association CY APR 08-10, 2010 CL Chicago, IL SP Amer Surg Assoc ID PROSPECTIVE MULTICENTER TRIAL; III COLON-CANCER; LYMPH-NODES; STAGE-III; ADJUVANT CHEMOTHERAPY; POOLED ANALYSIS; MICROMETASTASES; PROGNOSIS; CARCINOMA; THERAPY AB Background: The National Quality Forum has endorsed a minimum of 12 lymph node (LN) as a surrogate measure of quality in colorectal cancer (CRC). The prognostic value of ultrastaging hematoxylin and eosin (H&E) negative LNs (N0) using pan-cytokeratin immunohistochemistry (pan-CK-IHC) is unknown. Purpose: To assess the effect on survival of surgical quality and focused pathologic analysis. Patients and Methods: Between 2001 and 2007, 253 evaluable patients with resectable CRC were enrolled. Multiple sectioning and pan-CK-IHC were performed on N0 LNs (American Joint Commission on Cancer Stage II). Follow-up was performed at 6-month intervals with a 4-year disease-free survival (DFS) primary end-point. Results: There were 253 patients, 177 N0 and 76 N1/N2 patients, staged conventionally. Thirty-six (20%) N0 patients were upstaged using ultrastaging (N0 -> N0i+ [n = 27 ] and N0 -> N1mi [n = 9]). At a mean follow-up of 3.4 +/- 1.6 years, 38 (15%) have recurred. Only 3% (3/108) of patients with >= 12 LNs, negative by H&E and pan-CK-IHC (N0i-), compared with 18% (6/33) with <12 LNs/N0i- (6/33; P = 0.0015) have recurred. Four-year DFS differed significantly according to surgical quality (<12 vs. >= 12 LNs) among Stage II patients only (DFS, <12 vs. >= 12 LNs: Stage I, 90.5% vs. 97.7%, P = 0.22; Stage II, 67.5% vs. 94.7%, P = 0.0036; Stage III, 61% vs. 61%, P = 0.61). Conclusion: This represents the first prospective report demonstrating that both surgical quality and nodal ultrastaging impacts survival in Stage II CRC. Patients with Stage II CRC having >= 12 LNs negative for micrometastases (N0i-) are likely cured by surgery alone. Both surgical and pathologic quality measures are imperative in early CRC to improve patient selection for adjuvant chemotherapy. C1 [Bilchik, Anton] Univ Calif Los Angeles, David Geffen Sch Med, Calif Oncol Res Inst, Los Angeles, CA 90404 USA. [Bilchik, Anton; Nissan, Aviram; Protic, Mladjan; Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. [Nissan, Aviram] Hadassah Hebrew Univ Med Ctr, Jerusalem, Israel. [Shen, Perry] Wake Forest Univ, Winston Salem, NC 27109 USA. [McCarter, Martin] Univ Colorado, Denver Hlth Sci Ctr, Denver, CO 80202 USA. [Protic, Mladjan] Clin Ctr Vojvodina, Clin Abdominal Endocrine & Transplantat Surg, Novi Sad, Serbia. [Howard, Robin] Walter Reed Army Med Ctr, Div Biostat, Dept Clin Invest, Washington, DC 20307 USA. [Tyler, Josh; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Tyler, Josh; Peoples, George E.; Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Bilchik, A (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Calif Oncol Res Inst, 2336 Santa Monica Blvd,Suite 206, Los Angeles, CA 90404 USA. EM abilchik@mednet.ucla.edu FU NCI NIH HHS [2R01CA090848-05A2, R01 CA090848, R01 CA090848-05A2] NR 33 TC 34 Z9 34 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD SEP PY 2010 VL 252 IS 3 BP 467 EP 476 DI 10.1097/SLA.0b013e3181f19767 PG 10 WC Surgery SC Surgery GA 642TS UT WOS:000281242000007 PM 20739847 ER PT J AU Guntur, VP Waldrep, JC Guo, JJ Selting, K Dhand, R AF Guntur, Vamsi P. Waldrep, J. Clifford Guo, Jennifer J. Selting, Kim Dhand, Rajiv TI Increasing P53 Protein Sensitizes Non-Small Cell Lung Cancer to Paclitaxel and Cisplatin In Vitro SO ANTICANCER RESEARCH LA English DT Article DE p53; lung cancer; chemotherapy; cisplatin; paclitaxel; chemosensitivity ID WILD-TYPE P53; ADENOVIRUS-MEDIATED TRANSFER; AEROSOL DELIVERY; TUMOR-SUPPRESSOR; GENE-EXPRESSION; INTRATUMORAL DELIVERY; BREAST-CANCER; CHEMOSENSITIVITY; APOPTOSIS; INDUCTION AB Aim: To determine whether increasing p53 protein levels confers enhanced chemosensitivity in non-small cell lung cancer (NSCLC). Materials and Methods: Three NSCLC cell lines, with different endogenous p53 expression, were transfected with wild-type p53 (wt-p53) or CD-1 (truncated wt-p53) genes. Cells were subsequently treated with cisplatin (CDDP) or paclitaxel (PAX). Cell viability was measured using Alamar Blue Assay. Results: Cells transfected with CD-1 expressed 13-38% higher levels of p53 protein compared to cells transfected with the wt-p53 gene, despite their baseline endogenous levels. CD-1-transfected cells also had higher cell death when treated with CDDP (p<0.05) or PAX, exhibiting 30-60% higher death rates than cells transfected with the wt-p53 gene and 130-160% higher than untransfected cells. A significant positive correlation between p53 protein concentration and cytotoxic response was demonstrated (R(2) for CDDP=0.823; R(2) for PAX=0.909; p<0.001). Conclusion: Increasing intracellular p53 protein concentrations can augment the effect of CDDP and PAX in NSCLC, despite the baseline level of p53 protein expression. C1 [Guntur, Vamsi P.; Guo, Jennifer J.; Dhand, Rajiv] Univ Missouri, Div Pulm Crit Care & Environm Med, Sch Med, Columbia, MO 65212 USA. [Waldrep, J. Clifford] USA, Off Regulated Studies, Team Akimeka, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Selting, Kim] Univ Missouri, Dept Vet Med & Surg, Coll Vet Med, Columbia, MO 65211 USA. [Dhand, Rajiv] Harry S Truman Mem VA Hosp, Res Serv, Columbia, MO 65212 USA. RP Guntur, VP (reprint author), Univ Missouri, Div Pulm Crit Care & Environm Med, Sch Med, 5 Hosp Dr,DC043-00, Columbia, MO 65212 USA. EM gunturv@health.missouri.edu RI Mendez, Pedro /J-8955-2016 OI Mendez, Pedro /0000-0001-6713-7907 FU University of Missouri, Columbia, Missouri; Harry S. Truman VA Research Service, Columbia, Missouri; Joan's Legacy Foundation, New York FX The authors thank Drs M. Sharon Stack and Salman M. Nyder for valuable suggestions and critical reading of this manuscript. Research was funded by the University of Missouri, Columbia, Missouri; Harry S. Truman VA Research Service, Columbia, Missouri; and Joan's Legacy Foundation Grant, New York, New York. NR 48 TC 14 Z9 16 U1 1 U2 6 PU INT INST ANTICANCER RESEARCH PI ATHENS PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE SN 0250-7005 J9 ANTICANCER RES JI Anticancer Res. PD SEP PY 2010 VL 30 IS 9 BP 3557 EP 3564 PG 8 WC Oncology SC Oncology GA 665BI UT WOS:000283009400047 PM 20944137 ER PT J AU Auliff, AM Adams, JH O'Neil, MT Cheng, Q AF Auliff, Alyson M. Adams, John H. O'Neil, Michael T. Cheng, Qin TI Defining the Role of Mutations in Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Gene Using an Episomal Plasmodium falciparum Transfection System SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PAPUA-NEW-GUINEA; PYRIMETHAMINE RESISTANCE; SULFADOXINE-PYRIMETHAMINE; IN-VITRO; ANTIFOLATE RESISTANCE; MOLECULAR-PROPERTIES; EXPRESSION SYSTEM; MALARIA PARASITES; POINT MUTATIONS; CHLOROQUINE AB Plasmodium vivax resistance to antifolates is prevalent throughout Australasia and is caused by point mutations within the parasite dihydrofolate reductase (DHFR)-thymidylate synthase. Several unique mutations have been reported in P. vivax DHFR, and their roles in resistance to classic and novel antifolates are not entirely clear due, in part, to the inability to culture P. vivax in vitro. In this study, we use a homologous system to episomally express both wild-type and various mutant P. vivax dhfr (pvdhfr) alleles in an antifolate-sensitive line of P. falciparum and to assess their influences on the susceptibility of the recipient P. falciparum line to commonly used and new antifolate drugs. Although the wild-type pvdhfr-transfected P. falciparum line was as susceptible to antifolate drugs as the P. falciparum parent line, the single (117N), double (57L/117T and 58R/117T), and quadruple (57L/58R/61M/117T) mutant pvdhfr alleles conferred a marked reduction in their susceptibilities to antifolates. The resistance index increased with the number of mutations in these alleles, indicating that these mutations contribute to antifolate resistance directly. In contrast, the triple mutant allele (58R/61M/117T) significantly reversed the resistance to all antifolates, indicating that 61M may be a compensatory mutation. These findings help elucidate the mechanism of antifolate resistance and the effect of existing mutations in the parasite population on the current and new generation of antifolate drugs. It also demonstrates that the episomal transfection system has the potential to provide a rapid screening system for drug development and for studying drug resistance mechanisms in P. vivax. C1 [Auliff, Alyson M.; Cheng, Qin] Australian Army Malaria Inst, Dept Drug Resistance & Diagnost, Enoggera, Qld 4051, Australia. [Auliff, Alyson M.] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia. [Adams, John H.] Univ S Florida, Dept Global Hlth, Tampa, FL USA. [O'Neil, Michael T.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Cheng, Q (reprint author), Australian Army Malaria Inst, Dept Drug Resistance & Diagnost, Weary Dunlop Dr, Enoggera, Qld 4051, Australia. EM qin.cheng@defence.gov.au RI Adams, John/G-1800-2015 OI Adams, John/0000-0003-3707-7979 FU Australian Defence Force; NIH [R21 AI070888] FX We thank the Australian Defence Force for its funding of this study. This work was supported in part by NIH grant R21 AI070888 (J.H.A.). NR 45 TC 6 Z9 8 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2010 VL 54 IS 9 BP 3927 EP 3932 DI 10.1128/AAC.00628-10 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 639WC UT WOS:000281005900055 PM 20566761 ER PT J AU Butler, MM Williams, JD Peet, NP Moir, DT Panchal, RG Bavari, S Shinabarger, DL Bowlin, TL AF Butler, Michelle M. Williams, John D. Peet, Norton P. Moir, Donald T. Panchal, Rekha G. Bavari, Sina Shinabarger, Dean L. Bowlin, Terry L. TI Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article AB Antimicrobial susceptibilities of 233 Gram-positive and 180 Gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of Gram-positive bacteria, with MIC(90) values of 0.004 to 0.5 mu g/ml. One bis-indole, MBX 1162, exhibited potent activity against all Gram-negative strains, with MIC(90) values of 0.12 to 4 mu g/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens. C1 [Butler, Michelle M.; Williams, John D.; Peet, Norton P.; Moir, Donald T.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01605 USA. [Panchal, Rekha G.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Shinabarger, Dean L.] Micromyx, Kalamazoo, MI USA. RP Butler, MM (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01605 USA. EM mbutler@microbiotix.com FU DOD [HDTRA-06-C-0042] FX This project was supported by DOD contract no. HDTRA-06-C-0042. NR 8 TC 20 Z9 20 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2010 VL 54 IS 9 BP 3974 EP 3977 DI 10.1128/AAC.00484-10 PG 4 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 639WC UT WOS:000281005900065 PM 20625154 ER PT J AU Uchimiya, M AF Uchimiya, Minori TI Reductive Transformation of 2,4-Dinitrotoluene: Roles of Iron and Natural Organic Matter SO AQUATIC GEOCHEMISTRY LA English DT Article DE 2,4-Dinitrotoluene; Explosives; Electron transfer; Nitroaromatic compounds; Iron; Natural organic matter ID ABIOTIC REDUCTION; SUBSTITUTED NITROBENZENES; HUMIC SUBSTANCES; AQUEOUS-SOLUTION; CAFFEIC ACID; FE(II); LIGANDS; 2,6-DINITROTOLUENE; BIOTRANSFORMATION; NITROAROMATICS AB This study investigated the effects of redox-active and iron-coordinating functional groups within natural organic matter (NOM) on the electron transfer interactions between Fe(II) and 2,4-dinitrotoluene (2,4-DNT), an energetic residue often encountered in aqueous environments as a propellant component and impurities in 2,4,6-trinitrotoluene (TNT). Experiments were first conducted in homogeneous phases as a function of pH in the presence of ligands that (1) complex iron (e.g., citric acid, oxalic acid), (2) complex and reduce iron (e.g., caffeic acid, ascorbic acid), and (3) humic substances with known carboxyl content and electron transfer capacity. Then, effects of these NOM components on Fe(II) reactivity in heterogeneous media were investigated by introducing goethite. Our results indicate complex catalytic and inhibitory effects of NOM components on the reaction between Fe(II) and 2,4-DNT, depending upon the ability of NOM component to (1) reduce dissolved and particulate Fe(III) (e.g., ascorbic acid), (2) form kinetically labile dissolved Fe(II) reductants (e.g., tiron and caffeic acid), and (3) produce surface-associated Fe(II) species that are accessible to 2,4-DNT. C1 [Uchimiya, Minori] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Uchimiya, M (reprint author), ARS, USDA, 1100 Robert E Lee Blvd, New Orleans, LA 70124 USA. EM sophie.uchimiya@ars.usda.gov FU US Army Environmental Quality Technology Program at the Environmental Laboratory; US Army Engineer Research and Development Center (ERDC), Vicksburg, MS FX This project was supported by the US Army Environmental Quality Technology Program at the Environmental Laboratory, US Army Engineer Research and Development Center (ERDC), Vicksburg, MS. NR 36 TC 4 Z9 6 U1 3 U2 26 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1380-6165 J9 AQUAT GEOCHEM JI Aquat. Geochem. PD SEP PY 2010 VL 16 IS 4 BP 547 EP 562 DI 10.1007/s10498-009-9085-0 PG 16 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 617RL UT WOS:000279298700002 ER PT J AU Bilchik, A Stojadinovic, A AF Bilchik, Anton Stojadinovic, Alexander TI Is It Time to Move Beyond Lymph Node Evaluation in the Staging of Colon Cancer? INVITED CRITIQUE SO ARCHIVES OF SURGERY LA English DT Editorial Material ID INSTABILITY C1 [Bilchik, Anton] Univ Calif Los Angeles, Calif Oncol Res Inst, David Geffen Sch Med, Los Angeles, CA 90404 USA. [Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Bethesda, MD 20814 USA. RP Bilchik, A (reprint author), Univ Calif Los Angeles, Calif Oncol Res Inst, David Geffen Sch Med, 2336 Santa Monica Blvd,Ste 206, Los Angeles, CA 90404 USA. EM abilchik@mednet.ucla.edu NR 4 TC 1 Z9 1 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD SEP PY 2010 VL 145 IS 9 BP 830 EP 831 PG 2 WC Surgery SC Surgery GA 649JH UT WOS:000281764400005 PM 20873003 ER PT J AU Inaba, K Branco, BC Rhee, P Holcomb, JB Blackbourne, LH Shulman, I Nelson, J Demetriades, D AF Inaba, Kenji Branco, Bernardino C. Rhee, Peter Holcomb, John B. Blackbourne, Lorne H. Shulman, Ira Nelson, Janice Demetriades, Demetrios TI Impact of ABO-Identical vs ABO-Compatible Nonidentical Plasma Transfusion in Trauma Patients SO ARCHIVES OF SURGERY LA English DT Article ID FRESH-FROZEN PLASMA; DAMAGE CONTROL RESUSCITATION; RED-BLOOD-CELL; MASSIVE TRANSFUSION; NEUTROPHIL ACTIVATION; PLATELET TRANSFUSION; PRODUCT TRANSFUSION; EARLY COAGULOPATHY; HEMORRHAGIC-SHOCK; MORTALITY AB Hypothesis: Exposure to ABO-compatible nonidentical plasma will result in worse outcomes than transfusion with ABO-identical plasma only. Design: Retrospective study. Setting: Level I trauma center. Patients: All patients requiring plasma (from 2000-2008) were identified. Propensity scores were used to match patients exposed to ABO-compatible plasma with those receiving exclusively ABO-identical plasma. Main Outcome Measures: Mortality and complications (acute respiratory distress syndrome [ARDS]), sepsis, renal failure, and liver failure). Results: A total of 284 patients who received ABO-compatible nonidentical plasma were matched 1:1 with patients who received ABO-identical plasma only (230 group O, 39 A, and 15 B). ABO-compatible plasma did not affect mortality (35.2% vs 33.5%, P=.66). However, the overall complication rate was significantly higher for patients receiving ABO-compatible plasma (53.5% vs 40.5%, P=.002). The ARDS and sepsis rates were also significantly increased (19.4% vs 9.2%, P=.001, and 38.0% vs 28.9%, P=.02, respectively). As the volume of ABO-compatible plasma infused increased, a stepwise increase in complications was seen, reaching 70.0% for patients receiving more than 6 U. Patients receiving more than 6 U also had a 4-fold increase in ARDS. All recipient blood groups had an increase in overall complications, ARDS, and sepsis with exposure. This was significant for group 0 recipients with a higher risk of overall complications and ARDS (50.9% vs 40.0%, P=.03, and 17.4% vs 7.8%, P<.001, respectively). Conclusions: Exposure to ABO-compatible plasma results in an increase in overall complications, in particular ARDS and sepsis. There is a stepwise increase in the complication rate as exposure increases. Further prospective evaluation of the impact of limiting factor replacement to ABO-identical plasma only is warranted. C1 [Inaba, Kenji; Branco, Bernardino C.; Demetriades, Demetrios] Univ So Calif, Div Trauma & Surg Crit Care, Los Angeles, CA 90033 USA. [Rhee, Peter] Univ Arizona, Div Trauma Crit Care & Emergency Surg, Tucson, AZ USA. [Holcomb, John B.] Univ Texas Houston, Sch Med, Div Acute Care Surg, Ctr Translat Injury Res, Houston, TX USA. [Blackbourne, Lorne H.] US Army Inst Surg Res, San Antonio, TX USA. [Shulman, Ira; Nelson, Janice] Univ So Calif, Dept Pathol, Med Ctr, Los Angeles, CA 90089 USA. RP Inaba, K (reprint author), Univ So Calif, Div Trauma & Surg Crit Care, 1200 N State St,Room CL5100, Los Angeles, CA 90033 USA. EM kinaba@surgery.usc.edu NR 34 TC 45 Z9 45 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD SEP PY 2010 VL 145 IS 9 BP 899 EP 906 PG 8 WC Surgery SC Surgery GA 649JH UT WOS:000281764400024 PM 20855762 ER PT J AU Kolfenbach, JR Deane, KD Derber, LA O'Donnell, CI Gilliland, WR Edison, JD Rosen, A Darrah, E Norris, JM Holers, VM AF Kolfenbach, Jason R. Deane, Kevin D. Derber, Lezlie A. O'Donnell, Colin I. Gilliland, William R. Edison, Jess D. Rosen, Antony Darrah, Erika Norris, Jill M. Holers, V. Michael TI Autoimmunity to Peptidyl Arginine Deiminase Type 4 Precedes Clinical Onset of Rheumatoid Arthritis SO ARTHRITIS AND RHEUMATISM LA English DT Article ID CYCLIC CITRULLINATED PEPTIDE; SERUM IGG ANTIBODIES; DISEASE SEVERITY; ASSOCIATION; PADI4; AUTOANTIBODIES; PROGRESSION; PREDICT; ENZYME; REPLICATION AB Objective. To determine whether antibodies against peptidyl arginine deiminase type 4 (PAD-4) are present in the preclinical phase of rheumatoid arthritis (RA) and to compare the timing and extent of their appearance with those of other preclinical autoantibodies. Methods. Prediagnosis serum samples from 83 patients with RA were evaluated for the presence of anti-PAD-4 antibody, anti-cyclic citrullinated peptide (anti-CCP) antibody, and rheumatoid factor. In addition, a control cohort (n = 83) matched by age, sex, race, number of serum samples, and duration of serum storage was tested for the presence of anti-PAD-4 antibody to determine its sensitivity and specificity for the subsequent development of RA. Results. Fifteen of 83 patients with RA (18.1%) had at least 1 prediagnosis sample positive for anti-PAD-4. One of 83 control subjects (1.2%) had at least 1 positive sample, resulting in a sensitivity and specificity of 18.1% and 98.8%, respectively, of anti-PAD-4 for the future development of RA. The mean duration of anti-PAD-4 positivity prior to clinical diagnosis was 4.67 years. Anti-PAD-4 positivity was associated with anti-CCP positivity (odds ratio 5.13 [95% confidence interval 1.07-24.5]). In subjects with prediagnosis samples that were positive for both antibodies, anti-CCP positivity predated anti-PAD-4 positivity in 9 of 13 cases (69%). Conclusion. Autoantibodies to PAD-4 are present during the preclinical phase of RA in a subset of patients and are associated with anti-CCP positivity. Further exploration is needed regarding the timing of appearance and disease-related effects of PAD-4 auto-immunity. C1 [Holers, V. Michael] Univ Colorado Denver, Div Rheumatol, Dept Med, Aurora, CO 80045 USA. [O'Donnell, Colin I.; Norris, Jill M.] Colorado Sch Publ Hlth, Aurora, CO USA. [O'Donnell, Colin I.; Norris, Jill M.] Univ Colorado Denver, Aurora, CO USA. [Gilliland, William R.; Edison, Jess D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Rosen, Antony; Darrah, Erika] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Holers, VM (reprint author), Univ Colorado Denver, Div Rheumatol, Dept Med, 1775 Aurora Court,Mailstop B115, Aurora, CO 80045 USA. EM michael.holers@ucdenver.edu FU NIH [U19-AI-050864, R01-AR-051394, M01-RR-00069, M01-RR-00425, P30-AR-053503, K23-AR-051461, T32-AR-007534-23]; American College of Rheumatology Research and Education Foundation FX Supported by the NIH (Autoimmunity Prevention Center grants U19-AI-050864 and R01-AR-051394, General Clinical Research Centers Program/National Center for Research Resources grants M01-RR-00069 and M01-RR-00425, National Institute of Arthritis and Musculoskeletal and Skin Diseases grant P30-AR-053503, Career Development award K23-AR-051461, and National Research Service award T32-AR-007534-23) and by the American College of Rheumatology Research and Education Foundation (Within Our Reach program grant). NR 32 TC 35 Z9 36 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0004-3591 EI 1529-0131 J9 ARTHRITIS RHEUM-US JI Arthritis Rheum. PD SEP PY 2010 VL 62 IS 9 BP 2633 EP 2639 DI 10.1002/art.27570 PG 7 WC Rheumatology SC Rheumatology GA 665TT UT WOS:000283059100011 PM 20496417 ER PT J AU Singh, BR Thirunavukkarasu, N Ghosal, K Ravichandran, E Kukreja, R Cai, SW Zhang, P Ray, R Ray, P AF Singh, Bal Ram Thirunavukkarasu, Nagarajan Ghosal, Koyel Ravichandran, Easwaran Kukreja, Roshan Cai, Shuowei Zhang, Peng Ray, Radharaman Ray, Prabhati TI Clostridial neurotoxins as a drug delivery vehicle targeting nervous system SO BIOCHIMIE LA English DT Review DE Botulinum neurotoxins; Drug delivery vehicles; Neuronal disorders; Non-viral drug delivery ID RELEASE IN-VITRO; BOTULINUM-NEUROTOXIN; TETANUS TOXIN; SPINAL-CORD; INTRACELLULAR-TRANSPORT; NEURONS; FRAGMENT; TRANSLOCATION; INHIBITION; INJECTION AB Several neuronal disorders require drug treatment using drug delivery systems for specific delivery of the drugs for the targeted tissues, both at the peripheral and central nervous system levels. We describe a review of information currently available on the potential use of appropriate domains of clostridial neurotoxins, tetanus and botulinum, for effective drug delivery to neuronal systems. While both tetanus and botulinum neurotoxins are capable of delivering drugs the neuronal cells, tetanus neurotoxin is limited in clinical use because of general immunization of population against tetanus. Botulinum neurotoxin which is also being used as a therapeutic reagent has strong potential for drug delivery to nervous tissues. (C) 2010 Published by Elsevier Masson SAS. C1 [Singh, Bal Ram; Thirunavukkarasu, Nagarajan; Ghosal, Koyel; Ravichandran, Easwaran; Kukreja, Roshan; Cai, Shuowei] Univ Massachusetts, Natl Botulinum Res Ctr, Dartmouth, MA 02747 USA. [Singh, Bal Ram; Thirunavukkarasu, Nagarajan; Ghosal, Koyel; Ravichandran, Easwaran; Kukreja, Roshan; Cai, Shuowei] Univ Massachusetts, Dept Chem & Biochem, Dartmouth, MA 02747 USA. [Zhang, Peng; Ray, Prabhati] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ray, Radharaman] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. RP Singh, BR (reprint author), Univ Massachusetts, Natl Botulinum Res Ctr, Dartmouth, MA 02747 USA. EM bsingh@umassd.edu RI Ravichandran, Easwaran/N-7239-2016; OI Ravichandran, Easwaran/0000-0003-1613-0339; Ravichandran, Easwaran/0000-0002-5015-4492; Thirunavukkarasu, Nagarajan/0000-0003-0753-6265 FU DoD/Army [W81XWH-08-P-0705]; DARPA [GRANT W911NF-07-1-0623] FX This work was supported by the DoD/Army Contract W81XWH-08-P-0705 and DARPA Grant GRANT W911NF-07-1-0623. NR 49 TC 15 Z9 16 U1 1 U2 7 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0300-9084 J9 BIOCHIMIE JI Biochimie PD SEP PY 2010 VL 92 IS 9 BP 1252 EP 1259 DI 10.1016/j.biochi.2010.03.005 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 652GM UT WOS:000281991400022 PM 20346386 ER PT J AU Martin, MR Tipping, PW Reddy, KR Daroub, SH Roberts, KM AF Martin, Melissa R. Tipping, Philip W. Reddy, K. R. Daroub, Samira H. Roberts, Katrina M. TI Interactions of biological and herbicidal management of Melaleuca quinquenervia with fire: Consequences for ecosystem services SO BIOLOGICAL CONTROL LA English DT Article DE Fire; Invasion; Exotic; Nutrient; Melaleuca quinquenervia ID OXYOPS-VITIOSA COLEOPTERA; CONTROL AGENT; PLANT INVASION; INTRODUCED INSECTS; MICROBIAL BIOMASS; AUSTRALIAN WEEVIL; CAV. BLAKE,S.T.; HOST-RANGE; NITROGEN; DYNAMICS AB Exotic plant species invasion can alter ecosystem nutrient dynamics and natural disturbance patterns. The Australian tree Melaleuca quinquenervia has extensively invaded the Florida Everglades and is currently being suppressed using mechanical, herbicidal, and biological control management strategies. While these methods have been evaluated based on reductions in density and abundance of the target weed, other factors should be considered including consequences for ecosystem nutrient storages and interactions with natural disturbances such as fire. We hypothesized that the choice of management tactics, namely herbicidal or biological control, would differentially influence the quantity and availability of soil nutrients before and after a seasonal fire. The management of M. quinquenervia with a herbicide reduced the above-and belowground storage of nutrients both before and after a fire compared to a non-invaded area, while biological control increased storage. There were no differences in nitrogen availability between sites (non-invaded, herbicide, biological control) in the 0-5 cm or 5-15 cm soil depths before or after the fire. Pre-fire phosphorus availability was highest in the non-invaded site in the 05 cm soil depth and in the biological control site in the 5-15 cm soil depth. However, phosphorus availability was highest at both depths in the herbicide site post-fire. Biological control of M. quinquenervia using insect herbivores has proven to be effective at controlling plant growth and reproduction. The results of this study suggest that this method may have less of an impact on nutrient storage and cycling than herbicides. Published by Elsevier Inc. C1 [Martin, Melissa R.; Reddy, K. R.; Roberts, Katrina M.] Univ Florida, Dept Soil & Water Sci, Gainesville, FL 32611 USA. [Tipping, Philip W.] ARS, USDA, Invas Plant Res Lab, Ft Lauderdale, FL 33314 USA. [Daroub, Samira H.] Univ Florida, Everglades Res & Educ Ctr, Belle Glade, FL 33430 USA. RP Martin, MR (reprint author), USA, Corps Engineers, 9900 SW 107th Ave, Miami, FL 33176 USA. EM Melissa.R.Martin@usace.army.mil FU NSF-IGERT; UF, Soil and Water Science; Florida Exotic Pest Plant Council; Everglades Foundation FX We are especially appreciative of the invaluable insights and long hours of field support of the staff of the USDA-ARS Invasive Plant Research Laboratory, including Eileen Pokorny, Kayla Nimmo, Danyelle Fitzgerald, Susan Keusch, Elizabeth Mattison, and Elizabeth Bolton. We also thank Gavin Wilson, Yu Wang, and Vivana Nadal for laboratory and technical support. This work was partially funded by the Adaptive Management of Water, Wetlands, and Watershed program (NSF-IGERT), the Sam Polston Memorial Fellowship (UF, Soil and Water Science), the Julia Morton Invasive Plant Research Grant Program (Florida Exotic Pest Plant Council), and the Everglades Foundation Graduate Fellowship Program. NR 61 TC 6 Z9 6 U1 5 U2 25 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1049-9644 J9 BIOL CONTROL JI Biol. Control PD SEP PY 2010 VL 54 IS 3 BP 307 EP 315 DI 10.1016/j.biocontrol.2010.06.002 PG 9 WC Biotechnology & Applied Microbiology; Entomology SC Biotechnology & Applied Microbiology; Entomology GA 634RS UT WOS:000280602100020 ER PT J AU Aubin, H Nichol, JW Hutson, CB Bae, H Sieminski, AL Cropek, DM Akhyari, P Khademhosseini, A AF Aubin, Hug Nichol, Jason W. Hutson, Che B. Bae, Hojae Sieminski, Alisha L. Cropek, Donald M. Akhyari, Payam Khademhosseini, Ali TI Directed 3D cell alignment and elongation in microengineered hydrogels SO BIOMATERIALS LA English DT Article DE Tissue engineering; Micropatterning; Cellular alignment; 3D engineered tissue ID ELECTRICAL-STIMULATION; NUCLEAR-STRUCTURE; SHEAR-STRESS; TISSUE; DIFFERENTIATION; MIGRATION; MODEL; MATRIX; SHAPE; ORGANIZATION AB Organized cellular alignment is critical to controlling tissue microarchitecture and biological function. Although a multitude of techniques have been described to control cellular alignment in 2D, recapitulating the cellular alignment of highly organized native tissues in 3D engineered tissues remains a challenge. While cellular alignment in engineered tissues can be induced through the use of external physical stimuli, there are few simple techniques for microscale control of cell behavior that are largely cell-driven. In this study we present a simple and direct method to control the alignment and elongation of fibroblasts, myoblasts, endothelial cells and cardiac stem cells encapsulated in microengineered 3D gelatin methacrylate (GelMA) hydrogels, demonstrating that cells with the intrinsic potential to form aligned tissues in vivo will self-organize into functional tissues in vitro if confined in the appropriate 3D microarchitecture. The presented system may be used as an in vitro model for investigating cell and tissue morphogenesis in 3D, as well as for creating tissue constructs with microscale control of 3D cellular alignment and elongation, that could have great potential for the engineering of functional tissues with aligned cells and anisotropic function. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Aubin, Hug; Nichol, Jason W.; Hutson, Che B.; Bae, Hojae; Khademhosseini, Ali] Harvard Univ, Ctr Biomed Engn, Dept Med, Brigham & Womens Hosp,Med Sch, Cambridge, MA 02139 USA. [Aubin, Hug; Nichol, Jason W.; Hutson, Che B.; Bae, Hojae; Khademhosseini, Ali] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. [Sieminski, Alisha L.] Franklin W Olin Coll Engn, Needham, MA 02492 USA. [Cropek, Donald M.] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. [Akhyari, Payam] Univ Hosp Duesseldorf, Dept Cardiovasc Surg, Dusseldorf, Germany. RP Khademhosseini, A (reprint author), Harvard Univ, Ctr Biomed Engn, Dept Med, Brigham & Womens Hosp,Med Sch, 65 Landsdowne St, Cambridge, MA 02139 USA. EM alik@rics.bwh.harvard.edu RI Khademhosseini, Ali/A-9435-2010; OI Khademhosseini, Ali/0000-0002-2692-1524; Khademhosseini, Ali/0000-0001-6322-8852 FU National Institutes of Health [DE019024, HL092836]; National Science Foundation [DMR0847287]; Office of Naval Research; International Academy of Life Sciences (IALS); U.S. Army Construction Engineering Research Laboratory, Engineering Research and Development Center (USACERL/ERDC) FX This paper was supported by the National Institutes of Health (DE019024; HL092836), the National Science Foundation CAREER Award (DMR0847287) and the Office of Naval Research Young Investigator Award. H. A. was supported by the Biomedical Exchange Program from the International Academy of Life Sciences (BMEP/IALS). J.W.N. was supported by the U.S. Army Construction Engineering Research Laboratory, Engineering Research and Development Center (USACERL/ERDC). NR 55 TC 192 Z9 194 U1 14 U2 155 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9612 J9 BIOMATERIALS JI Biomaterials PD SEP PY 2010 VL 31 IS 27 BP 6941 EP 6951 DI 10.1016/j.biomaterials.2010.05.056 PG 11 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 634WJ UT WOS:000280616300006 PM 20638973 ER PT J AU Chretien, JP Yingst, SL Thompson, D AF Chretien, Jean-Paul Yingst, Samuel L. Thompson, Donald TI BUILDING PUBLIC HEALTH CAPACITY IN AFGHANISTAN TO IMPLEMENT THE INTERNATIONAL HEALTH REGULATIONS: A ROLE FOR SECURITY FORCES SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Editorial Material ID DISEASE; PERTUSSIS; PAKISTAN; OUTBREAK AB The government of Afghanistan, with international partners and donors, has achieved substantial public health improvements during the past 8 years. But a critical gap remains: capacities to detect and respond to disease outbreaks that could constitute a public health emergency of international concern, as required by the International Health Regulations (IHR). The Afghan Ministry of Public Health seeks to build these capacities, but conflict and scarcity of resources hinder public health surveillance and response, diagnostic laboratory and clinical management capacity is limited, and massive international population movements could permit outbreaks to cross international borders. Several diseases covered by the IHR, such as polio, are endemic in Afghanistan, and risk of novel disease emergence may be elevated in some areas. The security forces of the United States and other countries with military presence in Afghanistan are potential partners for the government of Afghanistan in strengthening the public health capacity. They could extend specialized disease surveillance and response capabilities to the Afghan military and civilian sectors and could integrate surveillance and response capacity building into ongoing development programs, especially in insecure areas. The World Health Organization could provide the forum for coordinating military and civilian contributions to public health capacity strengthening in Afghanistan and could help ensure that international health sector development efforts address Afghan public health priorities in addition to IHR requirements. C1 [Thompson, Donald] George Mason Univ, Sch Law, Ctr Infrastruct Protect & Homeland Secur, Publ Hlth Program, Arlington, VA USA. [Yingst, Samuel L.] Theater Reference Lab, Area Med Lab Task Force 1, Kandahar Airfield, Afghanistan. [Chretien, Jean-Paul] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. RP Chretien, JP (reprint author), Off Commanding Gen, PSC Box 20080, Camp Lejeune, NC 28542 USA. EM JPChretien@gmail.com OI Chretien, Jean-Paul/0000-0001-8143-6823 NR 37 TC 6 Z9 6 U1 0 U2 5 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD SEP PY 2010 VL 8 IS 3 BP 277 EP 285 DI 10.1089/bsp.2009.0058 PG 9 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 648BY UT WOS:000281666600015 PM 20825338 ER PT J AU Lotufo, GR Pickard, SW AF Lotufo, G. R. Pickard, S. W. TI Benthic Bioaccumulation and Bioavailability of Polybrominated Diphenyl Ethers from Surficial Lake Ontario Sediments Near Rochester, New York, USA SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article DE PDBE; Bioavailability; BSAF; Sediment ID BROMINATED FLAME RETARDANTS; LUMBRICULUS-VARIEGATUS; DAPHNIA-MAGNA; GREAT-LAKES; FOOD-WEB; INVERTEBRATES; TOXICITY AB Polybrominated diphenyl ethers in Lake Ontario watershed sediments were assessed for benthic bioavailability through the use of biota-sediment accumulation factors. Sediments from lake and Rochester Harbor (lower Genesee River) areas were investigated. Congeners 47, 66, 85, 99 and 100 were detected in tissues of the oligochaete Lumbriculus variegatus. Biota-sediment accumulation factors ranged from 3.95 (congener 154) to 19.5 (congener 28) and were higher at the Lake Ontario area. The lower biota-sediment accumulation factors for the Rochester Harbor sediment may result from a higher fraction of black carbon generally expected in highly urbanized rivers. Degree of bromination may reduce bioavailability. C1 [Lotufo, G. R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Pickard, S. W.] USA, Corps Engineers, Buffalo, NY 14207 USA. RP Lotufo, GR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM guilherme.lotufo@usace.army.mil FU USACE Buffalo District; US Army Engineer Research and Development Center FX We thank our colleagues Dennis Rimer, Jay Miller, William Butler, David Swiatek, Timothy Crockett, Michael Asquith (USACE Buffalo District) and Jerre Sims (US Army Engineer Research and Development Center) for their support on this work. NR 17 TC 1 Z9 1 U1 1 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD SEP PY 2010 VL 85 IS 3 BP 348 EP 351 DI 10.1007/s00128-010-0088-8 PG 4 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 644TF UT WOS:000281403300023 PM 20658224 ER PT J AU D'Avignon, LC Hogan, BK Murray, CK Loo, FL Hospenthal, DR Cancio, LC Kim, SH Renz, EM Barillo, D Holcomb, JB Wade, CE Wolf, SE AF D'Avignon, Laurie C. Hogan, Brian K. Murray, Clinton K. Loo, Florence L. Hospenthal, Duane R. Cancio, Leopoldo C. Kim, Seung H. Renz, Evan M. Barillo, David Holcomb, John B. Wade, Charles E. Wolf, Steven E. TI Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: An autopsy series SO BURNS LA English DT Article DE Mortality; Burn; Infection; Bacteria; Virus; Autopsy ID INTENSIVE-CARE UNIT; NOSOCOMIAL INFECTIONS; HERPETIC INFECTION; WOUND INFECTIONS; EXPERIENCE; SEPTICEMIA; SURVIVAL; INJURY; SEPSIS AB Bacterial infections are a common cause of mortality in burn patients and viral infections, notably herpes simplex virus (HSV) and cytomegalovirus (CMV) have also been associated with mortality. This study is a retrospective review of all autopsy reports from patients with severe thermal burns treated at the US Army Institute of Research (USAISR) burn unit over 12 years. The review focused on those patients with death attributed to a bacterial or viral cause by autopsy report. Of 3751 admissions, 228 patients died with 97 undergoing autopsy. Death was attributed to bacteria for 27 patients and to virus for 5 patients. Bacterial pathogens associated with mortality included Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. This association with mortality was independent of % total body surface area burn, % full-thickness burn, inhalation injury, and day of death post-burn. Bloodstream infection was the most common cause of bacteria related death (50%), followed by pneumonia (44%) and wound infection (6%). Time to death following burn was <= 7 days in 30%, <= 14 days in 59% and <= 21 days in 67%. All of the viral infections associated with mortality involved the lower respiratory tract, HSV for 4 and CMV for 1. Four of these 5 patients had evidence of inhalation injury by bronchoscopy, all had facial and neck burns, and 2 had concomitant Staphylococcus pneumonia. Time to death following burn ranged from 14 to 42 days for the 5 patients. Despite advances in care, gram negative bacterial infections and infection with S. aureus remain the most common cause of bacteria related mortality early in the hospital course. Viral infections are also associated with mortality and numbers have remained stable when compared to data from prior years. Published by Elsevier Ltd and ISBI C1 [D'Avignon, Laurie C.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [D'Avignon, Laurie C.; Hogan, Brian K.; Murray, Clinton K.; Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Loo, Florence L.] Pittsburgh Tissue Engn Initiat, Pittsburgh, PA USA. [Cancio, Leopoldo C.; Kim, Seung H.; Renz, Evan M.; Barillo, David; Holcomb, John B.; Wade, Charles E.; Wolf, Steven E.] USA, Inst Surg Res, Washington, DC USA. [D'Avignon, Laurie C.; Murray, Clinton K.; Hospenthal, Duane R.; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP D'Avignon, LC (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Laurie.Davigon@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 32 TC 47 Z9 47 U1 2 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD SEP PY 2010 VL 36 IS 6 BP 773 EP 779 DI 10.1016/j.burns.2009.11.007 PG 7 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 642CW UT WOS:000281182100006 PM 20074860 ER PT J AU Keen, EF Robinson, BJ Hospenthal, DR Aldous, WK Wolf, SE Chung, KK Murray, CK AF Keen, Edward F., III Robinson, Brian J. Hospenthal, Duane R. Aldous, Wade K. Wolf, Steven E. Chung, Kevin K. Murray, Clinton K. TI Prevalence of multidrug-resistant organisms recovered at a military burn center SO BURNS LA English DT Article DE Burn; Infection; Antibiotic resistance; Acinetobacter; Klebsiella; Pseudomonas; Staphylococcus ID GRAM-NEGATIVE BACILLI; BLOOD-STREAM INFECTIONS; ANTIMICROBIAL RESISTANCE; PSEUDOMONAS-AERUGINOSA; NATIONWIDE SURVEILLANCE; ACINETOBACTER-BAUMANNII; NO ESKAPE; SUSCEPTIBILITY; OPERATIONS; PERSONNEL AB Infections caused by multidrug-resistant (MDR) pathogens are associated with significant morbidity and mortality in patients with burn injuries. We performed a 6-year antibiotic susceptibility records review from January 2003 to December 2008 to assess the prevalence of MDR isolates by pathogen at the US Army Institute of Surgical Research Burn Center. During the study period Acinetobacter baumannii (780 isolates [22%]) was the most prevalent organism recovered, followed by Pseudomonas aeruginosa (703 isolates [20%]), Klebsiella pneumoniae (695 isolates [20%]), and Staphylococcus aureus (469 isolates [13%]). MDR prevalence rates among these isolates were A. baumannii 53%, methicillin-resistant S. aureus (MRSA) 34%, K. pneumoniae 17% and P. aeruginosa 15%. Two isolates, 1 A. baumannii and 1 P. aeruginosa, were identified as resistant to all 4 classes of antibiotics tested plus colistin. A. baumannii isolates recovered from patients with burns greater than 30% of total body surface area (TBSA) were more likely to be MDR (61%) with no significant difference for P. aeruginosa and K. pneumoniae. A higher proportion of MDR P. aeruginosa isolates were recovered from respiratory specimens compared to blood specimens (24% vs. 9%) while the opposite was true for MRSA (35% vs. 54%). A comparison of A. baumannii recovered during hospitalization days 1-5 and 15-30 revealed higher MDR levels as length of stay increased (48% vs. 75%) while no significant trends were observed for P. aeruginosa and K. pneumoniae. A similar pattern was observed for MDR A. baumannii levels for the facility between 2003 and 2005 and 2006-2008 (39% vs. 70%), with no significant increase in MDR P. aeruginosa and MDR K. pneumoniae. Increasing antibiotic resistance patterns of the most prevalent isolates recovered during extended hospitalization, impact of % TBSA and other clinical parameters may affect empirical antimicrobial therapy and patient management decisions during treatment. Published by Elsevier Ltd and ISBI C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Wolf, Steven E.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Hospenthal, Duane R.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 25 TC 52 Z9 54 U1 1 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD SEP PY 2010 VL 36 IS 6 BP 819 EP 825 DI 10.1016/j.burns.2009.10.013 PG 7 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 642CW UT WOS:000281182100013 PM 20080354 ER PT J AU Wu, XW Wolf, SE Walters, TJ AF Wu, Xiaowu Wolf, Steven E. Walters, Thomas J. TI Muscle contractile properties in severely burned rats SO BURNS LA English DT Article DE Atrophy; Thermal injury; Skin; Tetanic tension ID SKELETAL-MUSCLE; PROTEIN BREAKDOWN; GROWTH-HORMONE; THERMAL-INJURY; MICE; IMPAIRMENT; METABOLISM; MECHANISMS; SEPSIS; FIBERS AB Burn induces a sustained catabolic response which causes massive loss of muscle mass after injury. A better understanding of the dynamics of muscle wasting and its impact on muscle function is necessary for the development of effective treatments. Male Sprague-Dawley rats underwent either a 40% total body surface area (TBSA) scald burn or sham burn, and were further assigned to subgroups at four time points after injury (days 3, 7, 14 and 21). In situ isometric contractile properties were measured including twitch tension (Pt), tetanic tension (Po) and fatigue properties. Body weight decreased in burn and sham groups through day 3, however, body weight in the sham groups recovered and increased over time compared to burned groups, which progressively decreased until day 21 after injury. Significant differences in muscle wet weight and protein weight were found between sham and burn. Significant differences in muscle contractile properties were found at day 14 with lower absolute Po as well as specific Po in burned rats compared to sham. After burn, the muscle twitch tension was significantly higher than the sham at day 21. No significant difference in fatigue properties was found between the groups. This study demonstrates dynamics of muscle atrophy and muscle contractile properties after severe burn; this understanding will aid in the development of approaches designed to reduce the rate and extent of burn induced muscle loss and function. (C) 2010 Elsevier Ltd and ISBI. All rights reserved. C1 [Wu, Xiaowu; Wolf, Steven E.; Walters, Thomas J.] USA, Inst Surg Res, San Antonio, TX 78234 USA. [Wu, Xiaowu; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Wu, XW (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM xiaowu.wu@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 FU Combat Casualty Care Division, United States Army Medical Research and Materiel Command; National Institutes of Health [1 RO1 GM063120-04] FX Combat Casualty Care Division, United States Army Medical Research and Materiel Command and The National Institutes of Health (1 RO1 GM063120-04). NR 36 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD SEP PY 2010 VL 36 IS 6 BP 905 EP 911 DI 10.1016/j.burns.2010.02.003 PG 7 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 642CW UT WOS:000281182100026 PM 20381255 ER PT J AU Sonna, LA Kuhlmeier, MM Khatri, P Chen, D Lilly, CM AF Sonna, Larry A. Kuhlmeier, Matthew M. Khatri, Purvesh Chen, Dechang Lilly, Craig M. TI A microarray analysis of the effects of moderate hypothermia and rewarming on gene expression by human hepatocytes (HepG2) SO CELL STRESS & CHAPERONES LA English DT Article DE Cold stress; Cell stress response; DNA microarray; Heat shock proteins ID TRAUMATIC BRAIN-INJURY; HEAT-SHOCK PROTEINS; THERAPEUTIC HYPOTHERMIA; DNA MICROARRAY; CARDIAC-ARREST; COLD-EXPOSURE; ONTO-EXPRESS; RAT-BRAIN; STRESS; CELLS AB The gene expression changes produced by moderate hypothermia are not fully known, but appear to differ in important ways from those produced by heat shock. We examined the gene expression changes produced by moderate hypothermia and tested the hypothesis that rewarming after hypothermia approximates a heat-shock response. Six sets of human HepG2 hepatocytes were subjected to moderate hypothermia (31A degrees C for 16 h), a conventional in vitro heat shock (43A degrees C for 30 min) or control conditions (37A degrees C), then harvested immediately or allowed to recover for 3 h at 37A degrees C. Expression analysis was performed with Affymetrix U133A gene chips, using analysis of variance-based techniques. Moderate hypothermia led to distinct time-dependent expression changes, as did heat shock. Hypothermia initially caused statistically significant, greater than or equal to twofold changes in expression (relative to controls) of 409 sequences (143 increased and 266 decreased), whereas heat shock affected 71 (35 increased and 36 decreased). After 3 h of recovery, 192 sequences (83 increased, 109 decreased) were affected by hypothermia and 231 (146 increased, 85 decreased) by heat shock. Expression of many heat shock proteins was decreased by hypothermia but significantly increased after rewarming. A comparison of sequences affected by thermal stress without regard to the magnitude of change revealed that the overlap between heat and cold stress was greater after 3 h of recovery than immediately following thermal stress. Thus, while some overlap occurs (particularly after rewarming), moderate hypothermia produces extensive, time-dependent gene expression changes in HepG2 cells that differ in important ways from those induced by heat shock. C1 [Sonna, Larry A.] Univ Maryland, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD 21201 USA. [Sonna, Larry A.; Kuhlmeier, Matthew M.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Khatri, Purvesh] Wayne State Univ, Dept Comp Sci, Detroit, MI 48202 USA. [Chen, Dechang] Uniformed Serv Univ Hlth Sci, Div Epidemiol & Biostat, Bethesda, MD 20814 USA. [Lilly, Craig M.] Univ Massachusetts, Sch Med, Dept Med, Div Allergy Pulm & Crit Care Med, Worcester, MA 01655 USA. RP Sonna, LA (reprint author), Univ Maryland, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD 21201 USA. EM larry_sonna@yahoo.com FU US Army Medical Research and Materiel Command (USAMRMC); National Heart, Lung, and Blood Institute [HL-64104, HL-072114] FX Funding was provided by the US Army Medical Research and Materiel Command (USAMRMC). National Heart, Lung, and Blood Institute Grants HL-64104 and HL-072114 also supported this work. NR 33 TC 10 Z9 10 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1355-8145 J9 CELL STRESS CHAPERON JI Cell Stress Chaperones PD SEP PY 2010 VL 15 IS 5 BP 687 EP 702 DI 10.1007/s12192-010-0181-2 PG 16 WC Cell Biology SC Cell Biology GA 636YQ UT WOS:000280781800021 PM 20526826 ER PT J AU Gu, SP Maeng, S Suh, Y Levy, RA Deavenport, DL Gomez, FJ Newberg, SS Brooman, EW Berman, ES Kleek, JJ Beatty, JH Schwartz, AS Gaydos, SP AF Gu, Sipeng Maeng, Sungmin Suh, Yongseok Levy, Roland A. Deavenport, Dennis L. Gomez, Fernando J. Newberg, Samuel S. Brooman, Eric W. Berman, Elizabeth S. Kleek, John J. Beatty, John H. Schwartz, Andrew S. Gaydos, Stephen P. TI Investigation of Atmospheric Pressure CVD-Produced Aluminum Coatings for the Protection of Steel from Corrosion SO CHEMICAL VAPOR DEPOSITION LA English DT Article DE Aluminum; APCVD; Corrosion protection; Step coverage; TIBAL ID CHEMICAL-VAPOR-DEPOSITION; CHEMISTRY; CADMIUM AB This study investigates the use of atmospheric pressure (AP)CVD-produced aluminum (Al) coatings for the protection of steel from corrosion. Coatings produced through thermal decomposition of a triisobutylaluminum (TIBAL)-based precursor at 548 and 573 K are shown to exhibit growth rates of 0.5 and 1.1 mu m min(-1), respectively. Glow discharge optical emission spectroscopy (GDOES) reveals that, in the main, the coatings consist of pure Al with oxygen present as a minor constituent. Results of the structural, morphological, electrical, and mechanical characterization reveal that the APCVD Al coatings exhibit a face center cubic (fcc) structure with no preferred orientation, a non-columnar grain structure with grain size ranging from 3 to 10 mu m, and a surface roughness close to 2 mu m. Such coatings are also shown to offer an electrical resistivity of 3.5 mu Omega.cm, a density of 2.60 g cm(-3), and an adhesive strength of 703 kg cm(-2). Cross-sectional examination of coated samples indicate that the APCVD process can yield excellent step coverage and throwing power. Hydrogen embrittlement (HE) tests reveal that Al-coated bars with no post baking experience premature failure due to the presence of incorporated reaction product, hydrogen, in the steel substrate. Samples post-baked at 463 K for 23 h to remove the hydrogen from the substrate are shown to withstand the load for as long as 202 h. Corrosion studies conducted using potentiodynamic polarization measurements, electrochemical impedance spectroscopy, and salt fog tests show that the corrosion resistance of the APCVD Al coatings is comparable to that of pure Al foils, and that such coatings provide acceptable sacrificial protection for steel substrates. C1 [Gu, Sipeng; Maeng, Sungmin; Suh, Yongseok; Levy, Roland A.] New Jersey Inst Technol, Dept Phys, Newark, NJ 07102 USA. [Deavenport, Dennis L.] Akzo Nobel Polymer Chem, Deer Pk, TX 77536 USA. [Gomez, Fernando J.; Newberg, Samuel S.] Chem Innovat Unit Akzo Nobel, Chicago, IL USA. [Brooman, Eric W.; Berman, Elizabeth S.; Kleek, John J.] USAF, Mat & Mfg Directorate, Res Lab, Wright Patterson AFB, OH 45433 USA. [Beatty, John H.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Schwartz, Andrew S.] USN, Air Syst Command, Patuxent River, MD 20670 USA. [Gaydos, Stephen P.] Boeing Co, St Louis, MO 63166 USA. RP Gu, SP (reprint author), New Jersey Inst Technol, Dept Phys, Newark, NJ 07102 USA. EM sg75@njit.edu; yongseok.suh@gmail.com RI gu, sipeng/A-1991-2010 FU Strategic Environmental Research and Development Program (SERDP) FX This program was funded by a grant from the Strategic Environmental Research and Development Program (SERDP). NR 27 TC 3 Z9 3 U1 0 U2 11 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0948-1907 J9 CHEM VAPOR DEPOS JI Chem. Vapor Depos. PD SEP PY 2010 VL 16 IS 7-9 BP 231 EP 238 DI 10.1002/cvde.201006845 PG 8 WC Electrochemistry; Materials Science, Coatings & Films; Physics, Condensed Matter SC Electrochemistry; Materials Science; Physics GA 661QY UT WOS:000282744000007 ER PT J AU DiMeo, DF AF DiMeo, David F. TI Mahfouz between Lukacsian and Brechtian Approaches to Realism SO CLCWEB-COMPARATIVE LITERATURE AND CULTURE LA English DT Article AB In his article "Mahfouz between Lukacsian and Brechtian Approaches to Realism" David F. DiMeo compares the interpretations of realism by the leading Arabic author of socially committed fiction to the theories of Bertolt Brecht and Gyorgy Lukacs. The early works of novelist Najib Mahfouz feature a Lukacsian approach, embracing critical realism to present a totalizing view of the social system, as experienced by credible, sympathetic characters. By the 1960s, disillusioned with this method, Mahfouz turned to a more Brechtian approach, seeking to highlight social injustices by alienating the audience from identification with the characters or particular situations through ambiguous narratives and unsympathetic characters. While Mahfouz did not overtly claim allegiance to these European Marxist theorists, the similarity in his experiments with realism stems from two possible, but opposing interpretations of realism, the same interpretations which had divided Lukacs and Brecht. C1 US Mil Acad, West Point, NY 10996 USA. RP DiMeo, DF (reprint author), US Mil Acad, West Point, NY 10996 USA. EM david.dimeo@usma.edu NR 24 TC 0 Z9 0 U1 0 U2 1 PU PURDUE UNIV PRESS PI W LAFAYETTE PA 1207 SOUTH CAMPUS COURTS-E, W LAFAYETTE, IN 47907-1207 USA SN 1481-4374 J9 CLCWEB-COMP LIT CULT JI CLCWEB-Comp. Lit. Cult. PD SEP PY 2010 VL 12 IS 3 AR 10 PG 8 WC Literature SC Literature GA 673LK UT WOS:000283663600010 ER PT J AU Hamlet, AF Lee, SY Mickelson, KEB Elsner, MM AF Hamlet, Alan F. Lee, Se-Yeun Mickelson, Kristian E. B. Elsner, Marketa M. TI Effects of projected climate change on energy supply and demand in the Pacific Northwest and Washington State SO CLIMATIC CHANGE LA English DT Article ID COLUMBIA RIVER-BASIN; WATER-RESOURCES; PRECIPITATION AB Climate strongly affects energy supply and demand in the Pacific Northwest (PNW) and Washington State (WA). We evaluate potential effects of climate change on the seasonality and annual amount of PNW hydropower production, and on heating and cooling energy demand. Changes in hydropower production are estimated by linking simulated streamflow scenarios produced by a hydrology model to a simulation model of the Columbia River hydro system. Changes in energy demand are assessed using gridded estimates of heating degree days (HDD) and cooling degree days (CDD) which are then combined with population projections to create energy demand indices that respond both to climate, future population, and changes in residential air conditioning market penetration. We find that substantial changes in the amount and seasonality of energy supply and demand in the PNW are likely to occur over the next century in response to warming, precipitation changes, and population growth. By the 2040s hydropower production is projected to increase by 4.7-5.0% in winter, decrease by about 12.1-15.4% in summer, with annual reductions of 2.0-3.4%. Larger decreases of 17.1-20.8% in summer hydropower production are projected for the 2080s. Although the combined effects of population growth and warming are projected to increase heating energy demand overall (22-23% for the 2020s, 35-42% for the 2040s, and 56-74% for the 2080s), warming results in reduced per capita heating demand. Residential cooling energy demand (currently less than one percent of residential demand) increases rapidly (both overall and per capita) to 4.8-9.1% of the total demand by the 2080s due to increasing population, cooling degree days, and air conditioning penetration. C1 [Hamlet, Alan F.; Lee, Se-Yeun; Elsner, Marketa M.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Hamlet, Alan F.; Elsner, Marketa M.] Univ Washington, Climate Impacts Grp, Ctr Earth Syst Sci, Seattle, WA 98195 USA. [Mickelson, Kristian E. B.] USA, Corps Engineers, Seattle, WA 98134 USA. RP Hamlet, AF (reprint author), Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. EM hamleaf@u.washington.edu FU Washington State Legislature; NOAA [NA17RJ1232] FX This publication is part of the Washington Climate Change Impacts Assessment, funded by the 2007 Washington State Legislature through House Bill 1303. This publication is partially funded by the NOAA Regional Integrated Sciences and Assessments program and the NOAA Climate Dynamics and Experimental Prediction/Applied Research Centers program under NOAA Cooperative Agreement No. NA17RJ1232 to the Joint Institute for the Study of the Atmosphere and Ocean (JISAO). This is JISAO Contribution # 1791. NR 22 TC 53 Z9 53 U1 0 U2 20 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0165-0009 J9 CLIMATIC CHANGE JI Clim. Change PD SEP PY 2010 VL 102 IS 1-2 BP 103 EP 128 DI 10.1007/s10584-010-9857-y PG 26 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 652CL UT WOS:000281978500006 ER PT J AU Elsner, MM Cuo, L Voisin, N Deems, JS Hamlet, AF Vano, JA Mickelson, KEB Lee, SY Lettenmaier, DP AF Elsner, Marketa M. Cuo, Lan Voisin, Nathalie Deems, Jeffrey S. Hamlet, Alan F. Vano, Julie A. Mickelson, Kristian E. B. Lee, Se-Yeun Lettenmaier, Dennis P. TI Implications of 21st century climate change for the hydrology of Washington State SO CLIMATIC CHANGE LA English DT Article ID COLUMBIA RIVER-BASIN; WESTERN NORTH-AMERICA; CONTINENTAL UNITED-STATES; WATER-RESOURCES; CHANGE SCENARIOS; CHANGE IMPACTS; LAND-COVER; POTENTIAL IMPACTS; MOUNTAIN SNOWPACK; PACIFIC-NORTHWEST AB Pacific Northwest (PNW) hydrology is particularly sensitive to changes in climate because snowmelt dominates seasonal runoff, and temperature changes impact the rain/snow balance. Based on results from the Fourth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC AR4), we updated previous studies of implications of climate change on PNW hydrology. PNW 21st century hydrology was simulated using 20 Global Climate Models (GCMs) and 2 greenhouse gas emissions scenarios over Washington and the greater Columbia River watershed, with additional focus on the Yakima River watershed and the Puget Sound which are particularly sensitive to climate change. We evaluated projected changes in snow water equivalent (SWE), soil moisture, runoff, and streamflow for A1B and B1 emissions scenarios for the 2020s, 2040s, and 2080s. April 1 SWE is projected to decrease by approximately 38-46% by the 2040s (compared with the mean over water years 1917-2006), based on composite scenarios of B1 and A1B, respectively, which represent average effects of all climate models. In three relatively warm transient watersheds west of the Cascade crest, April 1 SWE is projected to almost completely disappear by the 2080s. By the 2080s, seasonal streamflow timing will shift significantly in both snowmelt dominant and rain-snow mixed watersheds. Annual runoff across the State is projected to increase by 2-3% by the 2040s; these changes are mainly driven by projected increases in winter precipitation. C1 [Elsner, Marketa M.; Hamlet, Alan F.; Lettenmaier, Dennis P.] Univ Washington, Ctr Earth Syst Sci, Climate Impacts Grp, Seattle, WA 98195 USA. [Cuo, Lan] Australia Commonwealth Sci & Ind Res Org CSIRO, Highett, Vic 3190, Australia. [Voisin, Nathalie; Hamlet, Alan F.; Vano, Julie A.; Lee, Se-Yeun; Lettenmaier, Dennis P.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Deems, Jeffrey S.] 449 UCB Univ Colorado, Natl Snow & Ice Data Ctr, Boulder, CO 80309 USA. [Mickelson, Kristian E. B.] USA, Corps Engineers, Seattle, WA 98124 USA. RP Elsner, MM (reprint author), Univ Washington, Ctr Earth Syst Sci, Climate Impacts Grp, Box 355672, Seattle, WA 98195 USA. EM mmcguire@uw.edu RI lettenmaier, dennis/F-8780-2011; Voisin, Nathalie/D-8845-2014; Deems, Jeffrey/E-6484-2016; OI lettenmaier, dennis/0000-0003-3317-1327; Deems, Jeffrey/0000-0002-3265-8670; Voisin, Nathalie/0000-0002-6848-449X FU Washington State Legislature; NOAA [NA17RJ1232] FX The authors thank Shraddhanand Shukla at the University of Washington and Andrew Wood of 3Tier for their consultation with respect to the 1/16th degree VIC model calibration and implementation. We also thank Tazebe Kiros Beyene and Elizabeth Clark at the University of Washington for their assistance with data analysis and troubleshooting, and Robert Norheim at the University of Washington Climate Impacts Group for his assistance with data analysis and graphics. Finally, we thank four anonymous reviewers who provided helpful comments that improved the manuscript. This publication is part of the Washington Climate Change Impacts Assessment, funded by the 2007 Washington State Legislature through House Bill 1303. This publication is partially funded by the NOAA Regional Integrated Sciences and Assessments program and the NOAA Climate Dynamics and Experimental Prediction/Applied Research Centers program under NOAA Cooperative Agreement No. NA17RJ1232 to the Joint Institute for the Study of the Atmosphere and Ocean (JISAO). This is JISAO Contribution # 1788. NR 70 TC 183 Z9 185 U1 11 U2 114 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0165-0009 EI 1573-1480 J9 CLIMATIC CHANGE JI Clim. Change PD SEP PY 2010 VL 102 IS 1-2 BP 225 EP 260 DI 10.1007/s10584-010-9855-0 PG 36 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 652CL UT WOS:000281978500010 ER PT J AU Vano, JA Scott, MJ Voisin, N Stockle, CO Hamlet, AF Mickelson, KEB Elsner, MM Lettenmaier, DP AF Vano, Julie A. Scott, Michael J. Voisin, Nathalie Stoeckle, Claudio O. Hamlet, Alan F. Mickelson, Kristian E. B. Elsner, Marketa McGuire Lettenmaier, Dennis P. TI Climate change impacts on water management and irrigated agriculture in the Yakima River Basin, Washington, USA SO CLIMATIC CHANGE LA English DT Article ID SNOWPACK; MODEL AB The Yakima River Reservoir system supplies water to similar to 180,000 irrigated hectares through the operation of five reservoirs with cumulative storage of similar to 30% mean annual river flow. Runoff is derived mostly from winter precipitation in the Cascade Mountains, much of which is stored as snowpack. Climate change is expected to result in earlier snowmelt runoff and reduced summer flows. Effects of these changes on irrigated agriculture were simulated using a reservoir system model coupled to a hydrological model driven by downscaled scenarios from 20 climate models archived by the 2007 Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report. We find earlier snowmelt results in increased water delivery curtailments. Historically, the basin experienced substantial water shortages in 14% of years. Without adaptations, for IPCC A1B global emission scenarios, water shortages increase to 27% (13% to 49% range) in the 2020s, to 33% in the 2040s, and 68% in the 2080s. For IPCC B1 emissions scenarios, shortages occur in 24% (7% to 54%) of years in the 2020s, 31% in the 2040s and 43% in the 2080s. Historically unprecedented conditions where senior water rights holders suffer shortfalls occur with increasing frequency in both A1B and B1 scenarios. Economic losses include expected annual production declines of 5%-16%, with greater probabilities of operating losses for junior water rights holders. C1 [Vano, Julie A.; Voisin, Nathalie; Hamlet, Alan F.; Mickelson, Kristian E. B.; Lettenmaier, Dennis P.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Scott, Michael J.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Stoeckle, Claudio O.] Washington State Univ, Dept Biol Syst Engn, Pullman, WA 99164 USA. [Hamlet, Alan F.; Elsner, Marketa McGuire; Lettenmaier, Dennis P.] Univ Washington, JISAO CSES Climate Impacts Grp, Seattle, WA 98195 USA. [Mickelson, Kristian E. B.] USA, Corps Engineers Seattle Dist, Seattle, WA 98134 USA. RP Vano, JA (reprint author), Univ Washington, Dept Civil & Environm Engn, Box 352700, Seattle, WA 98195 USA. EM jvano@u.washington.edu RI lettenmaier, dennis/F-8780-2011; Voisin, Nathalie/D-8845-2014; OI lettenmaier, dennis/0000-0003-3317-1327; Voisin, Nathalie/0000-0002-6848-449X FU Washington State Legislature; NOAA [NA17RJ1232] FX The authors thank Chris Lynch at the USBR for his insights into system operating procedures for the USBR Yakima Project and Lance Vail and Andre Coleman at Pacific Northwest National Laboratory for their assistance with the water management model simulations. Five anonymous reviewers also provided helpful feedback on earlier drafts of this paper. This publication is part of the Washington Climate Change Impacts Assessment, funded by the 2007 Washington State Legislature through House Bill 1303. This publication is partially funded by the NOAA Regional Integrated Sciences and Assessments program and the NOAA Climate Dynamics and Experimental Prediction/Applied Research Centers program under NOAA Cooperative Agreement No. NA17RJ1232 to the Joint Institute for the Study of the Atmosphere and Ocean (JISAO). This is JISAO Contribution # 1790. NR 32 TC 39 Z9 40 U1 2 U2 40 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0165-0009 J9 CLIMATIC CHANGE JI Clim. Change PD SEP PY 2010 VL 102 IS 1-2 BP 287 EP 317 DI 10.1007/s10584-010-9856-z PG 31 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 652CL UT WOS:000281978500012 ER PT J AU Campagna, J Crete, R Rooks, V Kratovil, T AF Campagna, John Crete, Ryan Rooks, Veronica Kratovil, Tonya TI An 18-Month-Old With Progressive Vomiting and Leg Pain SO CLINICAL PEDIATRICS LA English DT Editorial Material ID NERVOUS-SYSTEM TUMORS; MEDULLOBLASTOMA; CHILDHOOD; BRAIN C1 [Campagna, John] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96734 USA. [Crete, Ryan; Rooks, Veronica] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96734 USA. [Kratovil, Tonya] Tripler Army Med Ctr, Dept Pediat Hematol, Honolulu, HI 96734 USA. [Kratovil, Tonya] Tripler Army Med Ctr, Dept Oncol, Honolulu, HI 96734 USA. RP Campagna, J (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96734 USA. EM john.campagna2@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD SEP PY 2010 VL 49 IS 9 BP 897 EP 900 DI 10.1177/0009922809334353 PG 4 WC Pediatrics SC Pediatrics GA 636DE UT WOS:000280707600012 PM 19380882 ER PT J AU Corron, NJ Reed, BR Blakely, JN Myneni, K Pethel, SD AF Corron, Ned J. Reed, Billy R. Blakely, Jonathan N. Myneni, Krishna Pethel, Shawn D. TI Chaotic scrambling for wireless analog video SO COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION LA English DT Article DE Chaos communication; Synchronization; Video scrambling ID SYNCHRONIZATION; COMMUNICATION; SYSTEMS; UNMASKING AB We report the implementation of a novel in-band chaotic scrambler for securing wireless analog video. In this demonstration system, an analog video signal is injected into a chaotic oscillator and the output is transmitted through a standard wireless radio link. At the receiver, a descrambler separates the video from the chaotic signal in real time. Experimental results show the scrambled signal effectively hides the original video image, yet the descrambler recovers the original color video with reasonable clarity and detail. Compared to digital encryption, chaotic scrambling offers an efficient, low-cost alternative for masking time-critical analog communications. Published by Elsevier B.V. C1 [Corron, Ned J.; Blakely, Jonathan N.; Myneni, Krishna; Pethel, Shawn D.] USA, RDECOM, AMSRD RDMR WSS, Redstone Arsenal, AL 35898 USA. [Reed, Billy R.] Sci Applicat Int Corp, Huntsville, AL 35806 USA. RP Corron, NJ (reprint author), USA, RDECOM, AMSRD RDMR WSS, Redstone Arsenal, AL 35898 USA. EM ned.corron@us.army.mil OI Blakely, Jonathan/0000-0002-9772-582X; Corron, Ned/0000-0002-3232-5024 NR 29 TC 5 Z9 5 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1007-5704 EI 1878-7274 J9 COMMUN NONLINEAR SCI JI Commun. Nonlinear Sci. Numer. Simul. PD SEP PY 2010 VL 15 IS 9 BP 2504 EP 2513 DI 10.1016/j.cnsns.2009.10.007 PG 10 WC Mathematics, Applied; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas; Physics, Mathematical SC Mathematics; Mechanics; Physics GA 585JK UT WOS:000276821300032 ER PT J AU Pettway, JS Schmidt, JH Stagg, AK AF Pettway, Jackie S. Schmidt, Joseph H. Stagg, Alan K. TI Adaptive meshing in a mixed regime hydrologic simulation model SO COMPUTATIONAL GEOSCIENCES LA English DT Article DE Adaptive meshing; Parallel; Load balance; Hash tables ID QUALITY LOCAL REFINEMENT; FREE-BOUNDARY PROBLEMS; GRID REFINEMENT; POROUS-MEDIA; MESHES; ALGORITHM; BISECTION; FLOW; TRIANGULATIONS AB Problems in hydrology frequently have moving fronts and dynamic driving mechanisms such as wells. Since the location of important features changes during a simulation, accurate modeling requires uniformly fine resolution or the ability to change resolution during the simulation. We will describe an algorithm for refinement and unrefinement of tetrahedral/triangular meshes that has been implemented in the adaptive hydrology (ADH) code. The codes including the refinement/unrefinement algorithms are implemented in parallel to accommodate problems with large run time and memory requirements. In this paper, we describe the parallel, adaptive grid algorithm used in ADH and show the resulting grids from some example problems. C1 [Pettway, Jackie S.] Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Schmidt, Joseph H.] Los Alamos Natl Lab, Computat Anal & Simulat XCP 1, Los Alamos, NM 87545 USA. [Stagg, Alan K.] Los Alamos Natl Lab, Computat Anal & Simulat XCP 4, Los Alamos, NM 87545 USA. RP Pettway, JS (reprint author), Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. EM Jackie.S.Pettway@usace.army.mil; joe_schmidt@lanl.gov; stagg@lanl.gov FU United States Army Corps of Engineers (USACE) FX This work was funded by the United States Army Corps of Engineers (USACE). Permission was granted by the Chief of Engineers, USACE to publish this information. We would like to thank Lisa C. Roig, Charlie Berger, and Jennifer Tate. The Los Alamos National Laboratory strongly supports academic freedom and a researcher's right to publish; therefore, the laboratory as an institution does not endorse the viewpoint of a publication or guarantee its technical correctness. NR 32 TC 2 Z9 2 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1420-0597 J9 COMPUTAT GEOSCI JI Comput. Geosci. PD SEP PY 2010 VL 14 IS 4 BP 665 EP 674 DI 10.1007/s10596-010-9179-1 PG 10 WC Computer Science, Interdisciplinary Applications; Geosciences, Multidisciplinary SC Computer Science; Geology GA 641XL UT WOS:000281165800011 ER PT J AU Prewett, MS Johnson, RC Saboe, KN Elliott, LR Coovert, MD AF Prewett, Matthew S. Johnson, Ryan C. Saboe, Kristin N. Elliott, Linda R. Coovert, Michael D. TI Managing workload in human-robot interaction: A review of empirical studies SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Review DE Performance; Teleoperation; Automation; Perception; Display ID VIRTUAL ENVIRONMENTS; SITUATION AWARENESS; HUMAN-PERFORMANCE; CONTROL TASK; AUTOMATION; SYSTEM; RELIABILITY; DISPLAYS; RELIANCE; DESIGN AB Working with artificial agents is a challenging endeavor, often imposing high levels of workload on human operators who work within these socio-technical systems. We seek to understand these workload demands through examining the literature in major content areas of human-robot interaction. As research on HRI continues to explore a host of issues with operator workload, there is a need to synthesize the extant literature to determine its current state and to guide future research Within HRI socio-technical systems, we reviewed the empirical literature on operator information processing and action execution. Using multiple resource theory (MRT. Wickens, 2002) as a guiding framework, we organized this review by the operator perceptual and responding demands which are routinely manipulated in HRI studies We also reviewed the utility of different interventions for reducing the strain on the perceptual system (e g, multimodal displays) and responses (e g., automation) Our synthesis of the literature demonstrates that much is known about how to decrease operator workload, but there are specific gaps in knowledge clue to study operations and methodology This work furthers our understanding of workload in complex environments such as those found when working with robots. Principles and propositions are provided for those interested in decreasing operator workload in applied settings and also for future research. (C) 2010 Elsevier Ltd All rights reserved C1 [Prewett, Matthew S.; Johnson, Ryan C.; Saboe, Kristin N.; Coovert, Michael D.] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. [Elliott, Linda R.] USA, Army Res Lab, Ft Benning, GA USA. RP Prewett, MS (reprint author), Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. RI Saboe, Kristin/B-2322-2008 OI Saboe, Kristin/0000-0002-3588-2360 NR 100 TC 14 Z9 14 U1 1 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD SEP PY 2010 VL 26 IS 5 BP 840 EP 856 DI 10.1016/j.chb.2010.03.010 PG 17 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 615LY UT WOS:000279138000008 ER PT J AU Strawn, R AF Strawn, Roger TI High-Performance Computing for Rotorcraft Modeling and Simulation SO COMPUTING IN SCIENCE & ENGINEERING LA English DT Article AB A US Army software-development project aims to give domestic manufacturers a way to effectively design and upgrade rotorcraft systems with minimal development cost and risk. The project's software targets highly scalable supercomputer clusters, which can solve large problems for high-fidelity simulations. C1 USA, Aeroflightdynam Directorate, High Performance Comp Inst Adv Rotorcraft Modelin, Washington, DC USA. RP Strawn, R (reprint author), USA, Aeroflightdynam Directorate, High Performance Comp Inst Adv Rotorcraft Modelin, Washington, DC USA. EM roger.strawn@us.army.mil NR 15 TC 1 Z9 1 U1 1 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1521-9615 J9 COMPUT SCI ENG JI Comput. Sci. Eng. PD SEP-OCT PY 2010 VL 12 IS 5 BP 27 EP 35 PG 9 WC Computer Science, Interdisciplinary Applications SC Computer Science GA 643IQ UT WOS:000281289200008 ER PT J AU Campbell, T Allard, R Preller, R Smedstad, L Wallcraft, A Chen, S Jin, H Gabersek, S Hodur, R Reich, J Fry, CD Eccles, V Cheng, HP Cheng, JRC Hunter, R DeLuca, C Theurich, G AF Campbell, Tim Allard, Richard Preller, Ruth Smedstad, Lucy Wallcraft, Alan Chen, Sue Jin, Hao Gabersek, Sasa Hodur, Richard Reich, Joseph Fry, Craig D. Ghee Eccles, Vince Cheng, Hwai-Ping Cheng, Jing-Ru C. Hunter, Robert DeLuca, Cecelia Theurich, Gerhard TI Integrated Modeling of the Battlespace Environment SO COMPUTING IN SCIENCE & ENGINEERING LA English DT Article ID SOLAR-WIND AB The goal of the Battlespace Environments Institute (BE!) is to integrate Earth and space modeling capabilities into a seamless, whole-Earth common modeling infrastructure that facilitates interservice development of multiple, mission-specific environmental simulations and supports battlefield decisions, improves interoperability, and reduces operating costs. C1 [Campbell, Tim; Allard, Richard] USN, Res Lab, Oceanog Div,Nearshore & Coupled Models Sect, Stennis Space Ctr, MS USA. [Chen, Sue; Jin, Hao] USN, Res Lab, Marine Meteorol Div, Monterey, CA USA. [Hodur, Richard; Theurich, Gerhard] Sci Applicat Int Corp, Mclean, VA 22102 USA. [Reich, Joseph] USAF, Weather Agcy, Space Weather Integrat Team, Offutt AFB, NE USA. [Fry, Craig D. Ghee] Explorat Phys Int, Huntsville, AL USA. [Eccles, Vince] Space Environm Corp, Providence, UT USA. [Cheng, Jing-Ru C.; Hunter, Robert] USA, Engineer Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS USA. [DeLuca, Cecelia] NOAA, Cooperat Inst Res Environm Sci, Silver Spring, MD USA. RP Campbell, T (reprint author), USN, Res Lab, Oceanog Div,Nearshore & Coupled Models Sect, Stennis Space Ctr, MS USA. EM tim.campbell@nrlssc.navy.mil; richard.allard@nrlssc.navy.mil; ruth.preller@nrlssc.navy.mil; lucy.smedstad@nrlssc.navy.mil; alan.wallcraft@nrlssc.navy.mil; sue.chen@nrlmry.navy.mil; hao.jin@nrlmry.navy.mil; sasa.gabersek.ctr@nrlmry.navy.mil; richard.hodurctr@nrlmry.navy.mil; joseph.reich@offutt.af.mil; gfry@expi.com; vince@spacenv.com; hwai-ping.cheng@usace.army.mil; Ruth.C.Cheng@usace.army.mil; Robert.M.Hunter@usace.army.mil; cecelia.deluca@noaa.gov; theurich@sourcespring.net OI Allard, Richard/0000-0002-6066-2722 FU US DoD; NASA; NOAA National Weather Service and Climate Program Office; US National Science Foundation FX BEI is sponsored by the US DoD HPC Modernization Program (HPCMP) and we carried out our simulations at HPCMP supercomputing resource centers. We thank the NRL's Paul Martin, Paul May, James Doyle, and Eric Rogers for contributing both insight and code to the COAMPS project; and the ERDC's Jerry Lin for model construction, data analyses, and mesh generation. Support and funding for ESMF is through the DoD HPCMP, the NASA Modeling Analysis and Prediction Program, the NOAA National Weather Service and Climate Program Office, and the US National Science Foundation. COAMPS is a registered trademark of the US NRL. NR 20 TC 6 Z9 6 U1 0 U2 8 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1521-9615 J9 COMPUT SCI ENG JI Comput. Sci. Eng. PD SEP-OCT PY 2010 VL 12 IS 5 BP 36 EP 45 PG 10 WC Computer Science, Interdisciplinary Applications SC Computer Science GA 643IQ UT WOS:000281289200009 ER PT J AU Wallqvist, A Zavaljevski, N Satya, RV Bondugula, R Desai, V Hu, X Kumar, K Lee, MS Yeh, IC Yu, CG Reifman, J AF Wallqvist, Anders Zavaljevski, Nela Satya, Ravi Vijaya Bondugula, Rajkumar Desai, Valmik Hu, Xin Kumar, Kamal Lee, Michael S. Yeh, In-Chul Yu, Chenggang Reifman, Jaques TI Accelerating Biomedical Research in Designing Diagnostic Assays, Drugs, and Vaccines SO COMPUTING IN SCIENCE & ENGINEERING LA English DT Article ID PREDICTION; PROTEIN AB The US Department of Defense Biotechnology High-Performance Computing Software Applications Institute for Force Health Protection develops state-of-the-art high-performance computing applications that accelerate biomedical research in the development of diagnostic assays, drugs, and vaccines. The BHSAI works together with DoD life scientists to develop and integrate HPC software applications into DoD biomedical research programs. C1 [Wallqvist, Anders; Lee, Michael S.] USA, Med Res & Mat Command, Res Lab, Washington, DC 20310 USA. RP Wallqvist, A (reprint author), USA, Med Res & Mat Command, Res Lab, Washington, DC 20310 USA. EM awallqvist@bioanalysis.org; nelaz@bioanalysis.org; rsatya@bioanalysis.org; rbondugula@bioanalysis.org; valmik@bioanalysis.org; xhu@bioanalysis.org; kamal@bioanalysis.org; michael.scott.lee@us.army.mil; icy@bioanalysis.org; cyu@bioanalysis.org; jaques.reifman@us.army.mil OI Kumar, Kamal/0000-0002-9470-6682; wallqvist, anders/0000-0002-9775-7469 FU US DoD under the HPC Software Applications Institutes Initiative FX The US DoD HPC Modernization Program supports this work under the HPC Software Applications Institutes Initiative. The opinions and assertions contained herein are the authors' private views and aren't necessarily the views of the US Army or DoD. This article has been approved for public release. NR 12 TC 0 Z9 0 U1 0 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1521-9615 J9 COMPUT SCI ENG JI Comput. Sci. Eng. PD SEP-OCT PY 2010 VL 12 IS 5 BP 46 EP 55 PG 10 WC Computer Science, Interdisciplinary Applications SC Computer Science GA 643IQ UT WOS:000281289200010 ER PT J AU Horner, DA Eslinger, OJ Howington, SE Ketcham, SA Peters, JF Ballard, JR AF Horner, David A. Eslinger, Owen J. Howington, Stacy E. Ketcham, Stephen A. Peters, John F. Ballard, Jerrell R., Jr. TI Integrated High-Fidelity Geoscience Simulations for Enhanced Terrain-Related Target Detection SO COMPUTING IN SCIENCE & ENGINEERING LA English DT Article AB A loosely coupled suite of physics-based geotechnical, geospatial, hydrogeologic, and thermal simulations are integrated into a virtual testing facility aimed at resolving terrain-related war fighter problems. This article describes the key aspects of the research conducted by the US Institute for Maneuverability and Terrain Physics Simulation and provides two examples of the virtual testing facility applied to subsurface threat detection. C1 [Horner, David A.] USA, Engineer Res & Dev Ctr, Mil Engn Program, Washington, DC 20310 USA. [Eslinger, Owen J.] USA, Engineer Res & Dev Ctr, Informat Technol Lab, Washington, DC USA. [Howington, Stacy E.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Washington, DC USA. [Ketcham, Stephen A.] USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Washington, DC USA. [Peters, John F.; Ballard, Jerrell R., Jr.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Washington, DC USA. RP Horner, DA (reprint author), USA, Engineer Res & Dev Ctr, Mil Engn Program, Washington, DC 20310 USA. EM David.A.Horner@usace.army.mil; Owen.J.Eslinger@usace.army.mil; Stacy.E.Howington@usace.armymil; Steve.A.Ketcham@usace.army.mil; John.F.Peters@usace.army.mil; jerry.Ballard@usace.army.mil NR 11 TC 1 Z9 1 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1521-9615 J9 COMPUT SCI ENG JI Comput. Sci. Eng. PD SEP-OCT PY 2010 VL 12 IS 5 BP 56 EP 63 PG 8 WC Computer Science, Interdisciplinary Applications SC Computer Science GA 643IQ UT WOS:000281289200011 ER PT J AU O'Connor, FG Casa, DJ Bergeron, MF Carter, R Deuster, P Heled, Y Kark, J Leon, L MCDermott, B O'Brien, K Roberts, WO Sawka, M AF O'Connor, Francis G. Casa, Douglas J. Bergeron, Michael F. Carter, Robert, III Deuster, Patricia Heled, Yuval Kark, John Leon, Lisa MCDermott, Brendon O'Brien, Karen Roberts, William O. Sawka, Michael TI American College of Sports Medicine Roundtable on Exertional Heat Stroke - Return to Duty/Return to Play: Conference Proceedings SO CURRENT SPORTS MEDICINE REPORTS LA English DT Editorial Material ID GENE-EXPRESSION; RISK-FACTORS; HOT WEATHER; HEATSTROKE; ILLNESS; MARATHON; INTOLERANCE; EXERCISE; INJURY; TEMPERATURE AB O'CONNOR, F. G., D.J. CASA, M. F. BERGERON, R. CARTER, P. DEUSTER, Y. HELED, J. KARK, L. LEON, B. MCDERMOTT, K. O'BRIEN, W.O. ROBERTS, and M. SAWKA. American college of sports medicine roundtable on exertional heat stroke - return to duty/return to play: conference proceedings. Curr. Sports Med. Rep., Vol. 9, No. 5, pp. 314-321, 2010. On October 22Y23, 2008, an ACSM Roundtable was convened at the Uniformed Services University ( Bethesda, MD) to discuss return-to-play or return-to-duty for people who have experienced exertional heat illness (EHI) and to develop consensus-based recommendations. The conference assembled experts from the civilian sports medicine community and the Department of Defense to discuss relevant EHI issues, such as potential long-term consequences, the concept of thermotolerance, and the role of thermal tolerance testing in return-to-play decisions. Although the group was unable to move forward with new consensus recommendations, they clearly documented critical clinical concerns and scientific questions, including the following: 1) no uniform core definitions of EHI; 2) limited validated criteria to assess recovery from exertional heat stroke (EHS); and 3) inadequate ability to predict who may be predisposed to a subsequent heat injury after EHS. Areas of potential future research are identified. C1 [O'Connor, Francis G.; Deuster, Patricia] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, Bethesda, MD 20814 USA. [Casa, Douglas J.] Univ Connecticut, Korey Stringer Inst, Neag Sch Educ, Storrs, CT USA. [Bergeron, Michael F.] Univ S Dakota, Sanford Sch Med, Sioux Falls, SD USA. [Carter, Robert, III; Leon, Lisa; Sawka, Michael] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Heled, Yuval] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Kark, John] Thomas Jefferson Univ, Dept Hematol, Philadelphia, PA 19107 USA. [MCDermott, Brendon] Univ Tennessee, Dept Hlth & Human Performance, Chattanooga, TN USA. [O'Brien, Karen] USA, Training & Doctrine Command, Washington, DC USA. [Roberts, William O.] Univ Minnesota, Dept Family Med & Community Hlth, Minneapolis, MN USA. RP O'Connor, FG (reprint author), Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM foconnor@usuhs.mil RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 NR 70 TC 41 Z9 42 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD SEP-OCT PY 2010 VL 9 IS 5 BP 314 EP 321 DI 10.1249/JSR.0b013e3181f1d183 PG 8 WC Sport Sciences SC Sport Sciences GA 647UT UT WOS:000281645800014 PM 20827100 ER PT J AU Schwendiman, MN Turiansky, GW AF Schwendiman, Mark N. Turiansky, George W. TI What Is Your Diagnosis? Linear IgA Dermatosis SO CUTIS LA English DT Editorial Material ID CHRONIC BULLOUS DISEASE; TOXIC EPIDERMAL NECROLYSIS; STEVENS-JOHNSON-SYNDROME; DERMATITIS-HERPETIFORMIS; CHILDHOOD; IDENTIFICATION; VANCOMYCIN; ANTIGEN; SKIN; ACQUISITA C1 [Schwendiman, Mark N.] San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. [Turiansky, George W.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. [Turiansky, George W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Turiansky, George W.] Natl Naval Med Ctr, Dept Dermatol, Bethesda, MD USA. RP Schwendiman, MN (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. NR 32 TC 1 Z9 1 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD SEP PY 2010 VL 86 IS 3 BP 117 EP + PG 5 WC Dermatology SC Dermatology GA 662TM UT WOS:000282835700002 PM 21049726 ER PT J AU Fonda, SJ Jain, A Vigersky, RA AF Fonda, Stephanie J. Jain, Asha Vigersky, Robert A. TI A Head-to-Head Comparison of the Postprandial Effects of 3 Meal Replacement Beverages Among People With Type 2 Diabetes SO DIABETES EDUCATOR LA English DT Article ID UNDER-THE-CURVE; WEIGHT-LOSS; OBESE-PATIENTS; GLUCOSE; TRIAL; MANAGEMENT; DIET; FOOD AB Purpose The purpose of this study was to compare the effects of 3 meal replacement beverages on glycemic response among people with type 2 diabetes. Methods The study examined Glucerna (R) Weight Loss Shake, Slim-Fast (R) Shake, and Ensure (R) with Fiber Shake, using a prospective, 3-way, cross-over design. Eighteen subjects with type 2 diabetes drank the beverages in random order on different weeks. The volume of each beverage was adjusted to include 50 grams of carbohydrates. Glucose was measured 0 to 180 minutes postprandial. Analyses included 2-factor analysis of variance (ANOVA) for repeated measures on both factors, calculation of area under the curve (AUC), and 1-way repeated measures ANOVA of AUC. Results The postprandial glucose profiles of the shakes differed. Glucerna (R) had the best profile as indicated by the graph of mean postprandial glucose levels and its lower incremental AUC. Despite the superiority of Glucerna (R), 2-hour postprandial blood glucose values exceeded the ADA's recommended upper limit for 22% of the subjects. Conclusions Meal replacement beverages are a popular and potentially effective option for people trying to lose or maintain weight; however, it is unknown to what degrees they affect postprandial blood glucose in people with type 2 diabetes. Because postprandial glycemic excursion is linked to cardiovascular disease, identifying a meal replacement beverage with the lowest glycemic response may mitigate some of the risks in patients with diabetes. Of the meal replacements observed in this study, Glucerna (R) had the smallest effect on postprandial glucose. Glycemic response to meal replacements should be monitored given product and individual variability. C1 [Fonda, Stephanie J.; Vigersky, Robert A.] Gen Internal Med Serv, Walter Reed Army Med Ctr, Endocrinol Clin, Dept Med, Washington, DC USA. [Jain, Asha] Gen Internal Med Serv, Walter Reed Army Med Ctr, Wellness Serv, Washington, DC USA. RP Fonda, SJ (reprint author), Serv Endocrinol, Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW,Bldg 2,Room 7D, Washington, DC 20307 USA. EM stephanie.fonda@amedd.army.mil FU Department of Clinical Investigation at Walter Reed Army Medical Center, Washington, DC FX This study was supported by the Department of Clinical Investigation at Walter Reed Army Medical Center, Washington, DC. The authors have nothing further to disclose. Earlier versions of this article were presented at the Annual Meetings (2008) of the American Association of Diabetes Educators (in Washington, DC) and the American Diabetes Association (in San Francisco). The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or U.S. Government. NR 29 TC 1 Z9 2 U1 0 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0145-7217 J9 DIABETES EDUCATOR JI Diabetes Educ. PD SEP-OCT PY 2010 VL 36 IS 5 BP 793 EP 800 DI 10.1177/0145721710378537 PG 8 WC Endocrinology & Metabolism; Public, Environmental & Occupational Health SC Endocrinology & Metabolism; Public, Environmental & Occupational Health GA 682TU UT WOS:000284426700011 PM 20876307 ER PT J AU Rodbard, D Vigersky, RA AF Rodbard, D. Vigersky, R. A. TI Design and development of a computer assisted clinical decision support system to help physicians manage patients with type 2 diabetes mellitus SO DIABETOLOGIA LA English DT Meeting Abstract CT 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) CY SEP 20-24, 2010 CL Stockholm, SWEDEN SP European Assoc Study Diabetes C1 [Vigersky, R. A.] Walter Reed Army Med Ctr, Inst Diabet, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0012-186X J9 DIABETOLOGIA JI Diabetologia PD SEP PY 2010 VL 53 SU 1 MA 1036 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 635XA UT WOS:000280689701477 ER PT J AU Hassan, C Pickhardt, PJ Marmo, R Choi, JR AF Hassan, C. Pickhardt, P. J. Marmo, R. Choi, J. R. TI Impact of Lifestyle Factors on Colorectal Polyp Detection in the Screening Setting SO DISEASES OF THE COLON & RECTUM LA English DT Article DE Colorectal cancer screening; Lifestyle; Colorectal neoplasia; Alcohol; Smoking; Overweight; Obesity ID ADENOMATOUS POLYPS; ASYMPTOMATIC ADULTS; PROSPECTIVE COHORT; AMERICAN-COLLEGE; POOLED ANALYSIS; RISK-FACTORS; TASK-FORCE; CANCER; COLONOSCOPY; NEOPLASIA AB BACKGROUND: Awareness of risk factors for colorectal neoplasia could address risk reduction strategies in asymptomatic subjects. METHODS: This is a post hoc analysis of a prospective, cross-sectional study of 1321 asymptomatic adults. All the subjects underwent same-day CT colonography and colonoscopy to determine the prevalence of colorectal neoplasia. The variables examined included body mass index, smoking, alcohol consumption, age, and gender. Univariate and logistic regression analyses were performed for detection of colorectal neoplasia and hyperplastic polyps. Odds ratios with 95% confidence intervals were calculated. RESULTS: Colorectal adenomas and hyperplastic polyps were detected in 378 (28.6%) and 157 (11.9%) participants, respectively. In both univariate and multivariate analysis, increasing age, male gender, and body mass index >= 25 were significantly associated with the detection of colorectal adenomas, with an odds ratio of 1.22 (95% CI, 1.09-1.36), 1.28 (95% CI, 1.06-1.45), and 1.34 (95% CI, 1.02-1.77), respectively. A history of smoking was the only identifiable risk factor for hyperplastic polyps (odds ratio, 1.98; 95% CI, 1.41-2.78). CONCLUSIONS: Body mass index >= 25, increasing age, and male gender were all associated with an increased likelihood of colorectal adenomas at screening, whereas smoking was strongly associated with hyperplastic polyps. C1 [Hassan, C.] Nuovo Regina Margherita Hosp, Gastroenterol Unit, I-00153 Rome, Italy. [Pickhardt, P. J.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Radiol, Madison, WI USA. [Pickhardt, P. J.] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. [Marmo, R.] L Curto Hosp, Div Gastroenterol, Polla, Sant Arsenio, Italy. [Choi, J. R.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Hassan, C (reprint author), Nuovo Regina Margherita Hosp, Gastroenterol Unit, Via Morosini 30, I-00153 Rome, Italy. EM cesareh@hotmail.com FU NCI NIH HHS [R01 CA144835] NR 27 TC 25 Z9 26 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0012-3706 J9 DIS COLON RECTUM JI Dis. Colon Rectum PD SEP PY 2010 VL 53 IS 9 BP 1328 EP 1333 DI 10.1007/DCR.0b013e3181e10daa PG 6 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA 640XY UT WOS:000281088700015 PM 20706078 ER PT J AU Keefer, ML Taylor, GA Garletts, DF Gauthier, GA Pierce, TM Caudill, CC AF Keefer, M. L. Taylor, G. A. Garletts, D. F. Gauthier, G. A. Pierce, T. M. Caudill, C. C. TI Prespawn mortality in adult spring Chinook salmon outplanted above barrier dams SO ECOLOGY OF FRESHWATER FISH LA English DT Article DE Oncorhynchus; prespawn mortality; supplementation; temperature; Willamette River ID RIVER SOCKEYE-SALMON; COLUMBIA RIVER; ONCORHYNCHUS-NERKA; PACIFIC SALMON; ARTIFICIAL PROPAGATION; ANADROMOUS SALMONIDS; SPAWNING MIGRATION; UPSTREAM MIGRATION; STEELHEAD; TEMPERATURE AB Dams without fish passage facilities block access to much of the historic spawning habitat of spring Chinook salmon (Oncorhynchus tshawytscha) in Oregon's Willamette River basin. Adult salmon are routinely outplanted above the dams to supplement natural production, but many die before spawning despite extensive suitable habitat. In 2004-2007, we examined prespawn mortality patterns using live detection and carcass recovery data for 242 radio-tagged outplants. Total prespawn mortality was 48%, but variability was high, ranging from 0% to 93% for individual release groups. Prespawn mortality was strongly condition dependent, consistently higher for females than males and higher for early release groups. Across years, warm water temperature in the migration corridor and at the collection site was associated with sharply higher mortality. Results highlight a need for better evaluations of the effects of adult mortality on population reintroduction and recovery and relationships among prespawn mortality, dam-related temperature change and salmon life history and behaviour. C1 [Keefer, M. L.; Caudill, C. C.] Univ Idaho, Dept Fish & Wildlife Resources, Idaho Cooperat Fish & Wildlife Res Unit, Moscow, ID 83844 USA. [Taylor, G. A.; Garletts, D. F.; Gauthier, G. A.; Pierce, T. M.] USA, Corps Engineers, Lowell, OR 97452 USA. RP Keefer, ML (reprint author), Univ Idaho, Dept Fish & Wildlife Resources, Idaho Cooperat Fish & Wildlife Res Unit, Moscow, ID 83844 USA. EM mkeefer@uidaho.edu RI Caudill, Christopher/M-7906-2014 NR 51 TC 24 Z9 24 U1 8 U2 34 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0906-6691 J9 ECOL FRESHW FISH JI Ecol. Freshw. Fish PD SEP PY 2010 VL 19 IS 3 BP 361 EP 372 DI 10.1111/j.1600-0633.2010.00418.x PG 12 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 639SQ UT WOS:000280995200005 ER PT J AU Rong, C Jiang, RZ Sarney, W Chu, D AF Rong, Charles Jiang, Rongzhong Sarney, Wendy Chu, Deryn TI Ultrasound-assisted micro-emulsion for synthesis of Pt and PtCo nano-particles SO ELECTROCHIMICA ACTA LA English DT Article DE Micro-emulsion synthesis; Nano-particles; Oxygen reduction; Catalysts; PtCo ID METHANOL FUEL-CELLS; PLATINUM-RUTHENIUM NANOPARTICLES; OXYGEN REDUCTION REACTION; TEMPERATURE-DEPENDENCE; MESOPOROUS CARBON; REVERSE MICELLE; CATALYSTS; ELECTROCATALYSTS; CO; PERFORMANCE AB Several wet chemical methods were examined for synthesis of Pt and PtCo nano-particles, including normal chemical synthesis, micro-emulsion synthesis, and ultrasound-assisted micro-emulsion synthesis. High resolution transmission electron microscopy (TEM). X-ray diffraction analysis (XRD) and cyclic voltammetry (CV) were used for the characterization. The PtCo synthesized with ultrasound-assisted micro-emulsion showed a uniform particle size distribution. We can control the particle size from 17 nm to 3 nm by varying the synthetic environment, such as the water/oil ratio, water/surfactant ratio, reactant concentration, and pH value in water phase. The CV results showed that by applying ultrasound-assisted micro-emulsion for synthesis of PtCo catalyst, the catalytic peak current for oxygen reduction increased 15% over the PtCo synthesized by micro-emulsion but without applying ultrasound in the synthetic environment, and 47% over the PtCo synthesized by normal chemical method. The catalytic peak potential for the PtCo synthesized with ultrasound-assisted micro-emulsion had 30 mV positive shift for O(2) reduction in comparison with that synthesized by micro-emulsion without applying ultrasound, and 100 mV positive shift in comparison with that synthesized by normal chemical method. Published by Elsevier Ltd. C1 [Rong, Charles; Jiang, Rongzhong; Sarney, Wendy; Chu, Deryn] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Jiang, RZ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Rongzhong.jiang@us.army.mil FU U.S. Army Research Laboratory FX The authors wish to thank Professor Chunsheng Wang and Dr. Li-Chung Lai at University of Maryland for assisting TEM analysis, Dr. Cynthia Lundgren for helpful discussions, and the Director's Research Initiative Program of the U.S. Army Research Laboratory for financial support. NR 43 TC 7 Z9 7 U1 4 U2 35 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD SEP 1 PY 2010 VL 55 IS 22 BP 6872 EP 6878 DI 10.1016/j.electacta.2010.05.078 PG 7 WC Electrochemistry SC Electrochemistry GA 645YC UT WOS:000281501100070 ER PT J AU Bastian, ND Trainor, TE AF Bastian, Nathaniel D. Trainor, Timothy E. TI Going Green at West Point: Is It Economically Beneficial? A Cost-Benefit Analysis of Installing a Wind Farm at the United States Military Academy SO EMJ-ENGINEERING MANAGEMENT JOURNAL LA English DT Article DE Engineering Economics; Cost-Benefit Analysis; Forecast Modeling; Decision Analysis; Wind Energy AB In 2007, BQ Energy communicated an idea to the United States Military Academy (USMA) at West Point, NY, about the construction of a 12.5 MW wind farm for electricity production on the western edge of its property in the training grounds near Camp Buckner. Such a project would bring educational, strategic, and potentially economic benefits to USMA, in addition to the obvious environmental benefits that would be realized by the Hudson Valley region. This article describes a quantitative approach to answer why it is financially beneficial for West Point to allow the installation of a wind farm on its property. C1 [Bastian, Nathaniel D.] USA, Med Serv Corps, Army Med Dept, Daleville, AL 36322 USA. [Trainor, Timothy E.] US Mil Acad, Acad Board, West Point, NY USA. RP Bastian, ND (reprint author), USA, Med Serv Corps, Army Med Dept, 71 AM Windham Dr Apt 300, Daleville, AL 36322 USA. EM nathaniel.bastian@fulbrightmail.org NR 23 TC 6 Z9 6 U1 1 U2 7 PU AMER SOC ENGINEERING MANAGEMENT PI ROLLA PA PO BOX 820, ROLLA, MO 65402 USA SN 1042-9247 J9 EMJ-ENG MANAG J JI EMJ-Eng. Manag. J. PD SEP PY 2010 VL 22 IS 3 SI SI BP 12 EP 20 PG 9 WC Engineering, Industrial; Management SC Engineering; Business & Economics GA V24BD UT WOS:000208385000003 ER PT J AU Kwon, S Thomas, J Reed, BE Levine, L Magar, VS Farrar, D Bridges, TS Ghosh, U AF Kwon, Seokjoon Thomas, Jeff Reed, Brian E. Levine, Laura Magar, Victor S. Farrar, Daniel Bridges, Todd S. Ghosh, Upal TI EVALUATION OF SORBENT AMENDMENTS FOR IN SITU REMEDIATION OF METAL-CONTAMINATED SEDIMENTS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Sediment; Remediation; Heavy metals; Amendments; Biouptake ID ACTIVATED CARBON; LEPTOCHEIRUS-PLUMULOSUS; TRACE-METALS; HEAVY-METAL; BIOAVAILABILITY; ADSORPTION; ESTUARINE; TOXICITY; REMOVAL; IONS AB The present study evaluated sorbent amendments for in situ remediation of sediments contaminated with two divalent metals. A literature review screening was performed to identify low-cost natural mineral-based metal sorbents and high-performance commercial sorbents that were carried forward into laboratory experiments. Aqueous phase metal sorptivity of the selected sorbents was evaluated because dissolved metals in sediment porewater constitute an important route of exposure to benthic organisms. Based on pH-edge sorption test results, natural sorbents were eliminated due to inferior performance. The potential as in situ sediment amendment was explored by comparing the sorption properties of the engineered amendments in freshwater and saltwater (10 PPT salinity estuarine water) matrices. Self-assembled monolayers on mesoporous supports with thiols (Thiol-SAMMS (TM)) and a titanosilicate mineral (ATS (TM)) demonstrated the highest sorption capacity for cadmium (Cd) and lead (Pb), respectively. Sequential extraction tests conducted after mixing engineered sorbents with contaminated sediment demonstrated transfer of metal contaminants from a weakly bound state to a more strongly bound state. Biouptake of Cd in a freshwater oligochaete was reduced by 98% after 5-d contact of sediment with 4% Thiol-SAMMS and sorbed Cd was not bioavailable. While treatment with ATS reduced the small easily extractable portion of Pb in the sediment, the change in biouptake of Pb was not significant because most of the native lead was strongly bound. The selected sorbents added to sediments at a dose of 5% were mostly nontoxic to a range of sensitive freshwater and estuarine benthic organisms. Metal sorbent amendments in conjunction with activated carbon have the potential to simultaneously reduce metal and hydrophobic contaminant bioavailability in sediments. Environ. Toxicol. Chem. 2010;29:1883-1892. (C) 2010 SETAC C1 [Kwon, Seokjoon; Thomas, Jeff; Reed, Brian E.; Ghosh, Upal] Univ Maryland Baltimore Cty, Dept Civil & Environm Engn, Baltimore, MD 21227 USA. [Levine, Laura] CH2MHill, San Francisco, CA 94105 USA. [Magar, Victor S.] ENVIRON Int Corp, Chicago, IL 60606 USA. [Farrar, Daniel; Bridges, Todd S.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Ghosh, U (reprint author), Univ Maryland Baltimore Cty, Dept Civil & Environm Engn, 5200 Westland Blvd, Baltimore, MD 21227 USA. EM ughosh@umbc.edu FU Department of Defense [ER-1491] FX This work was supported by the Department of Defense Strategic Environmental Research and Development Program through project ER-1491. The authors thank John Higley from Steward Environmental for providing Thiol-SAMMS for the present study and Derek Arnold for laboratory assistance in this project. NR 40 TC 7 Z9 7 U1 1 U2 29 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD SEP PY 2010 VL 29 IS 9 BP 1883 EP 1892 DI 10.1002/etc.249 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 642HX UT WOS:000281200700002 PM 20821645 ER PT J AU Liu, W Gibbons, RV Kari, K Clemens, JD Nisalak, A Marks, F Xu, ZY AF Liu, W. Gibbons, R. V. Kari, K. Clemens, J. D. Nisalak, A. Marks, F. Xu, Z. Y. TI Risk factors for Japanese encephalitis: a case-control study SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Arbovirus infections; arboviruses; Japanese encephalitis virus; risk factors; surveillance ID CEREBROSPINAL-FLUID; IMMUNOGLOBULIN-M; EPIDEMIOLOGY; VIRUS; IMMUNIZATION; SERUM AB Japanese encephalitis (JE) has been found to be endemic in Bali, Indonesia. A case-control study was conducted to identify factors associated with JE infection. All 94 serologically confirmed JE cases (cases) and 163 cases of encephalitis or aseptic meningitis without JE (controls) identified in Bali during 2001-2004 were included in the study. Potential risk factors were surveyed at hospital admission. Univariate analyses revealed the following factors to be associated with JE: older age, referral from sub-district health centre or private hospital, playing outdoors after dinner, use of mosquito repellent or spraying, proximity of the residence to rice fields, and pig ownership by the family or next-door neighbours. Multivariate analysis identified proximity to rice fields (OR 2.93, 95% CI 1.57-5.45), pig ownership (OR 2.24, 95% CI 1.17-4.26), and older age (OR 1.21, 95% CI 1.09-1.33) as being independently associated with the risk of JE. Because rice cultivation and pig rearing are essential to the economy of Bali, JE immunization is the best intervention for prevention of JE in Bali. C1 [Liu, W.; Clemens, J. D.; Marks, F.; Xu, Z. Y.] Int Vaccine Inst, Seoul, South Korea. [Gibbons, R. V.; Marks, F.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Kari, K.] Udayana Univ, Sch Med, Dept Paediat, Bali, Indonesia. RP Liu, W (reprint author), Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. EM wliu@hsph.harvard.edu FU Bill and Melinda Gates Children's Vaccine Program (CVP) [00-GAT.770-790-01149-LPS]; Korean International Cooperation Agency (KOICA) [2003-001] FX This study received financial support from the Bill and Melinda Gates Children's Vaccine Program (CVP) through the Program for Appropriate Technology for Health (PATH), Seattle, WA, USA (contract no: 00-GAT.770-790-01149-LPS) and from the Korean International Cooperation Agency (KOICA contract no: 2003-001). We thank Wayan Yastini, I. Gst Ayu Joni and Panor Srisongkram for their assistance in performing diagnostic testing, and Dayu Ratna Dewi and Dewa Gede Sura Dharma for their assistance in specimen transportation and coordination with paediatricians in Bali. W. Liu is currently affiliated with Department of Epidemiology, Harvard School of Public Health, Boston, MA. NR 21 TC 12 Z9 14 U1 0 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD SEP PY 2010 VL 138 IS 9 BP 1292 EP 1297 DI 10.1017/S0950268810000063 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 643DT UT WOS:000281275300011 PM 20109262 ER PT J AU Yang, H Wang, Z Capo-Aponte, JE Zhang, F Pan, Z Reinach, PS AF Yang, H. Wang, Z. Capo-Aponte, J. E. Zhang, F. Pan, Z. Reinach, P. S. TI Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells SO EXPERIMENTAL EYE RESEARCH LA English DT Article DE cannabinoid receptor 1 (CB1); transient receptor potential vanilloid 1 (TRPV1); epidermal growth factor receptor (EGFR); proinflammatory cytokine; transactivation; cell proliferation; cell migration; protein phosphorylation ID EGFR ACTIVATION; WOUNDING SHEETS; MAP KINASE; PROLIFERATION; ANANDAMIDE; MOTILITY; NEURONS; INFLAMMATION; STIMULATION; MECHANISMS AB Corneal epithelial injury induces release of endogenous metabolites that are cannabinoid receptor 1 (CB1) and transient receptor potential vanilloid 1 (TRPV1) agonists. We determined the functional contributions by CB1 and TRPV1 activation to eliciting responses underlying wound healing in human corneal epithelial cells (HCEC). Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response. Furthermore. EGFR transactivation was abolished by inhibitors of proteolytic release of heparin bound EGF (HB-EGF). CB1-induced Ca(2+) transients were reduced during exposure to either the CB1 antagonist, AM251 or AG1478. Both CAP and WIN induced transient increases in Erk1/2, p38, JNK1/2 MAPK and Akt/PI-3K phosphorylation status resulting in cell proliferation and migration increases which mirrored those elicited by EGF. Neither EGF nor WIN induced any increases in IL-6 and IL-8 release. On the other hand, CAP-induced 3- and 6-fold increases, which were fully attenuated during exposure to CPZ, but AG1478 only suppressed them by 21%. The mixed CB1 and TRPV1 antagonist, AM251, enhanced the CAP-induced rise in IL-8 release to a higher level than that elicited by CAP alone. In conclusion, CB1 and TRPV1 activation induces increases in HCEC proliferation and migration through EGFR transactivation leading to global MAPK and Akt/PI-3K pathway stimulation. On the other hand, the TRPV1-mediated increases in IL-6 and IL-8 release are elicited through both EGFR dependent and EGFR-independent signaling pathways. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Yang, H.; Wang, Z.; Capo-Aponte, J. E.; Zhang, F.; Pan, Z.; Reinach, P. S.] SUNY, State Coll Optometry, Dept Biol Sci, New York, NY 10036 USA. [Capo-Aponte, J. E.] USA, Visual Sci Branch, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Reinach, PS (reprint author), SUNY, State Coll Optometry, Dept Biol Sci, New York, NY 10036 USA. EM preinach@sunyopt.edu RI Pan, Zan/E-5106-2011 FU National Institutes of Health [EY04795]; Department of Defense [W81XWH-09-2-0162] FX The authors thank Dr. Jin Zhao support for immunocytochemistry work. This work was supported in part by grants from National Institutes of Health (EY04795) and Department of Defense (W81XWH-09-2-0162). NR 49 TC 40 Z9 42 U1 0 U2 3 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0014-4835 J9 EXP EYE RES JI Exp. Eye Res. PD SEP PY 2010 VL 91 IS 3 BP 462 EP 471 DI 10.1016/j.exer.2010.06.022 PG 10 WC Ophthalmology SC Ophthalmology GA 645XY UT WOS:000281500700018 PM 20619260 ER PT J AU Paris, RM Kim, JH Robb, ML Michael, NL AF Paris, Robert M. Kim, Jerome H. Robb, Merlin L. Michael, Nelson L. TI Prime-boost immunization with poxvirus or adenovirus vectors as a strategy to develop a protective vaccine for HIV-1 SO EXPERT REVIEW OF VACCINES LA English DT Review DE DNA; HIV-1; vaccine; vector; virus ID T-CELL RESPONSES; VIRUS ANKARA MVA; GP160 RECOMBINANT VACCINIA; CTL ESCAPE MUTATIONS; I CLINICAL-TRIAL; SIMIAN IMMUNODEFICIENCY; IMMUNE-RESPONSES; CANARYPOX VACCINE; CANDIDATE VACCINE; ALVAC-HIV AB Challenges in the development of an effective HIV-1 vaccine are myriad with significant hurdles posed by viral diversity, the lack of a human correlate of protection and difficulty in creating immunogens capable of eliciting broadly neutralizing antibodies. The implicit requirement for novel approaches to these problems has resulted in vaccine candidates designed to elicit cellular and/or humoral immune responses, to include recombinant DNA, viral and bacterial vectors, and subunit proteins. Here, we review data from clinical studies primarily of poxvirus and adenovirus vector vaccines, used in a heterologous prime boost combination strategy. Currently, this strategy appears to hold the most promise for an effective vaccine based on results from immunogenicity testing and nonhuman primate challenge models, as well as the modest efficacy recently observed in the Thai prime boost trial. C1 [Paris, Robert M.] Armed Forces Res Inst Med Sci, Dept Retrovirol, US Mil HIV Res Program MHRP, Bangkok 10400, Thailand. [Kim, Jerome H.; Robb, Merlin L.; Michael, Nelson L.] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD USA. [Robb, Merlin L.] Henry M Jackson Fdn, Rockville, MD USA. RP Paris, RM (reprint author), Armed Forces Res Inst Med Sci, Dept Retrovirol, US Mil HIV Res Program MHRP, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM robert.paris@afrims.org FU US Army Medical Research and Materiel Command (USAMRMC); Henry M Jackson Foundation [DAMD17-98-2-7007] FX The authors received funding from the US Army Medical Research and Materiel Command (USAMRMC), and its Cooperative Agreement (DAMD17-98-2-7007) with the Henry M Jackson Foundation for the Advancement of Military Medicine. The views expressed in this manuscript are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense or the US Government. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 152 TC 45 Z9 47 U1 1 U2 5 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD SEP PY 2010 VL 9 IS 9 BP 1055 EP 1069 DI 10.1586/ERV.10.106 PG 15 WC Immunology SC Immunology GA 653SO UT WOS:000282117200012 PM 20822348 ER PT J AU Grossman, LC Michalakis, KG Browne, H Payson, MD Segars, JH AF Grossman, Lisa C. Michalakis, Konstantinos G. Browne, Hyacinth Payson, Mark D. Segars, James H. TI The pathophysiology of ovarian hyperstimulation syndrome: an unrecognized compartment syndrome SO FERTILITY AND STERILITY LA English DT Article DE Ovarian hyperstimulation syndrome (OHSS); abdominal compartment syndrome (ACS); intraabdominal pressure (IAP); intraabdominal hypertension (IAH); paracentesis ID ENDOTHELIAL GROWTH-FACTOR; IN-VITRO FERTILIZATION; STIMULATING-HORMONE RECEPTOR; JUGULAR-VEIN THROMBOSIS; MASSIVE VULVAR EDEMA; OF-THE-LITERATURE; ABDOMINAL COMPARTMENT; INTRAABDOMINAL HYPERTENSION; FACTOR VEGF; PARACENTESIS AB Objective: To compare and contrast the pathophysiology of ovarian hyperstimualtion syndrome (OHSS) with known syndromes of increased intraabdominal pressure (IAP), and to explore the relationship of increased IAP with symptom severity in OHSS. Design: Literature review. Main Outcome Measure(s): Correlation of OHSS symptoms with IAP; effects of paracentesis on IAP in patients with OHSS. Setting: Academic Research Institution. Intervention(s): None. Result(s): OHSS involves a rapid accumulation of volume (from 1.5-17 liters) in the peritoneal cavity that can lead to organ dysfunction, including respiratory impairment and oliguria. In published reports of 20 moderate-to-severe OHSS patients in whom IAP was measured, IAP was found to be elevated to a pathologic range. The increased IAP indicates that OHSS may be considered a compartment syndrome and meets criteria for abdominal compartment syndrome in advanced cases. For this reason, management of OHSS should include reduction of pressure by paracentesis to avoid morbidity and syndrome progression. In addition, measurement of IAP may help to classify the stage of OHSS. Conclusion(s): IAP was found to be elevated in the few cases of OHSS in which it was measured, substantiating the conclusion that OHSS may be considered a compartment syndrome. An understanding of the pathophysiology of increased intrabdominal pressure is useful in the management of OHSS. (Fertil Steril (R) 2010;94:1392-8. (C) 2010 by American Society for Reproductive Medicine.) C1 [Segars, James H.] NICHHD, Reprod Biol & Med Branch, NIH, CRC, Bethesda, MD 20892 USA. [Grossman, Lisa C.] Georgetown Univ, Sch Med, Washington, DC USA. [Payson, Mark D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Segars, JH (reprint author), NICHHD, Reprod Biol & Med Branch, NIH, CRC, 10 Ctr Dr,Bldg 10,1E-3140, Bethesda, MD 20892 USA. EM segarsj@mail.nih.gov FU Reproductive Biology and Medicine Branch, NICHD, NIH FX Supported, in part, by the Intramural Research Program of the Reproductive Biology and Medicine Branch, NICHD, NIH. NR 68 TC 18 Z9 19 U1 1 U2 12 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2010 VL 94 IS 4 BP 1392 EP 1398 DI 10.1016/j.fertnstert.2009.07.1662 PG 7 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 648FA UT WOS:000281674600038 PM 19836016 ER PT J AU Banks, NK Norian, JM DeCherney, AH Henne, MB AF Banks, N. K. Norian, J. M. DeCherney, A. H. Henne, M. B. TI INSURANCE MANDATES AND ASSISTED REPRODUCTIVE TECHNOLOGY (ART): HOW WERE TREATMENTS AND OUTCOMES IMPACTED BY IMPLEMENTATION OF A MANDATE IN NEW JERSEY? SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM 2010) CY OCT 23-27, 2010 CL Denver, CO SP Amer Soc Reproductive Med C1 Georgetown Univ Hosp, Dept Obstet & Gynecol, Washington, DC 20007 USA. Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Reprod Biol & Med Branch, Bethesda, MD USA. Walter Reed Army Med Ctr, Assisted Reprod Technol Program, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2010 VL 94 IS 4 SU 1 BP S167 EP S167 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 645GR UT WOS:000281441000568 ER PT J AU Maguire, M Csokmay, J Hill, M Segars, J Armstrong, A AF Maguire, M. Csokmay, J. Hill, M. Segars, J. Armstrong, A. TI OBESITY IS ASSOCIATED WITH LOWER LIVE BIRTH RATES IN FRESH, BUT NOT FROZEN EMBRYO TRANSFER CYCLES. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM 2010) CY OCT 23-27, 2010 CL Denver, CO SP Amer Soc Reproductive Med C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA. Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2010 VL 94 IS 4 SU 1 BP S18 EP S19 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 645GR UT WOS:000281441000063 ER PT J AU Moon, KS Csokmay, JM Armstrong, AY Segars, JH Stegmann, BJ AF Moon, K. S. Csokmay, J. M. Armstrong, A. Y. Segars, J. H. Stegmann, B. J. TI ELEVATED ESTRADIOL LEVELS IN AFRICAN-AMERICAN WOMEN MAY EXPLAIN THE REDUCED LIVE BIRTH RATES FOLLOWING ASSISTED REPRODUCTION. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 66th Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM 2010) CY OCT 23-27, 2010 CL Denver, CO SP Amer Soc Reproduct Med C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, Bethesda, MD USA. Univ Iowa, Hosp & Clin, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, Iowa City, IA USA. Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2010 VL 94 IS 4 SU 1 BP S242 EP S242 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 645GR UT WOS:000281441000830 ER PT J AU Moon, KS Stegmann, BJ Yauger, BJ Segars, JH AF Moon, K. S. Stegmann, B. J. Yauger, B. J. Segars, J. H. TI ARE THERE PROVIDER-DEPENDENT DIFFERENCES IN THE LEARNING CURVE FOR PROFICIENCY WITH OOCYTE RETRIEVALS? SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 66th Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM 2010) CY OCT 23-27, 2010 CL Denver, CO SP Amer Soc Reproduct Med C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, Bethesda, MD USA. Univ Iowa, Hosp & Clin, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, Iowa City, IA USA. Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2010 VL 94 IS 4 SU 1 BP S242 EP S243 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 645GR UT WOS:000281441000832 ER PT J AU Moon, KS Zhou, Y Mumford, S Segars, JH Armstrong, AY AF Moon, K. S. Zhou, Y. Mumford, S. Segars, J. H. Armstrong, A. Y. TI SERUM ANTI-MULLERIAN HORMONE LEVELS DO NOT CORRELATE WITH CYCLOPHOSPHAMIDE-INDUCED PRIMORDIAL FOLLICULAR DESTRUCTION IN MICE PRETREATED WITH CETRORELIX. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM 2010) CY OCT 23-27, 2010 CL Denver, CO SP Amer Soc Reproductive Med C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, Bethesda, MD USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2010 VL 94 IS 4 SU 1 BP S104 EP S105 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 645GR UT WOS:000281441000354 ER PT J AU Parker, J Eldridge, D Sanchez, L Sawmiller, J Gonzalez, I Anderson, J AF Parker, J. Eldridge, D. Sanchez, L. Sawmiller, J. Gonzalez, I. Anderson, J. TI THE INCIDENCE OF ECTOPIC PREGNANCY RATES FOLLOWING SALINE INFUSION SONO-HYSTEROGRAPHY (SIS) AMONG DIFFERENT INFERTILITY SUBTYPES. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM 2010) CY OCT 23-27, 2010 CL Denver, CO SP Amer Soc Reproductive Med C1 [Parker, J.; Eldridge, D.; Sanchez, L.; Sawmiller, J.; Gonzalez, I.; Anderson, J.] Womack AMC, Dept GYN, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2010 VL 94 IS 4 SU 1 BP S212 EP S212 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 645GR UT WOS:000281441000725 ER PT J AU Johnson, JB Ford, WM Edwards, JW Menzel, MA AF Johnson, Joshua B. Ford, W. Mark Edwards, John W. Menzel, Michael A. TI Bat community structure within riparian areas of northwestern Georgia, USA SO FOLIA ZOOLOGICA LA English DT Article DE Anabat; Eptesicus; Lasiurus; Myotis; nonmetric multidimensional scaling; Perimyotis; regression tree; species richness ID MOUNTAIN-RANGE FOREST; INSECTIVOROUS BATS; TEMPORAL PATTERNS; HABITAT USE; WATER; VEGETATION; LANDSCAPE; GRADIENT; ECOLOGY; SCALES AB Although it is well known that bats commonly forage in riparian areas, which provide water resources and insect concentrations, the role that the physical structure of riparian areas plays in influencing local bat communities is less certain. In 2000-2002, we used acoustic monitoring to determine bat species presence at 338 riparian sites in northwestern Georgia, USA. We used a 2-dimensional nonmetric multidimensional scaling (NMDS) ordination to assess how separations among species were partially associated with riparian conditions. Our NMDS analysis found some degree of habitat partitioning among bat species occurring in northwestern Georgia and was dictated in part by riparian condition. Myotis grisescens and M septentrionalis were associated with low-elevation lotic waterways, whereas M lucifugus, Lasiurus borealis, and Eptesicus fuscus were associated with high-elevation lentic waterways with sparse canopy cover. However, riparian conditions had weak relations with NMDS axes, possibly resulting in coincidental associations in some cases. Regression tree analysis indicated that higher bat species richness was associated with apparently uncommon small, high-elevation waterways with sparse canopy cover as well as larger streams and rivers that had wetlands adjacent to them. Including high-elevation waterways with existing management recommendations for endangered M grisescens foraging areas (large, low-elevation streams and rivers) will be the most effective conservation strategy to benefit the most bat species in northwestern Georgia and probably elsewhere in the southern Appalachians. C1 [Johnson, Joshua B.; Edwards, John W.; Menzel, Michael A.] W Virginia Univ, Div Forestry & Nat Resources, Morgantown, WV 26506 USA. [Ford, W. Mark] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Johnson, JB (reprint author), W Virginia Univ, Div Forestry & Nat Resources, Morgantown, WV 26506 USA. EM j-johnson3@juno.com; William.M.Ford@usace.army; jedwards@wvu.edu FU Georgia Department of Natural Resources (GA DNR); National Park Service (NPS) FX Georgia Department of Natural Resources (GA DNR) and National Park Service (NPS) provided funding, housing, and support for this project. J. Ozier, N. Holcomb, A. Padgett, T Gilbreath, and T Touchstone of the GA DNR and J.. Szyjkowski of the NPS provided invaluable assistance and logistic support. We thank M Strager of West Virginia University (WVU) and S. Koonce of the United States Department of Agriculture (USDA) Forest Service for assistance with Geographic Information Systems. G. Merovich (WVU) provided much appreciated assistance with statistical coding in R and a review of this manuscript. We thank B. Sparks and S. Sutton for providing field assistance. In-kind support was provided by USDA Forest Service Northern Research Station and WVU Division of Forestry and Natural Resources. We thank 2 anonymous reviewers of this manuscript for their helpful comments. NR 53 TC 5 Z9 9 U1 2 U2 35 PU INST VERTEBRATE BIOLOGY AS CR PI BRNO PA KVETNA 8, BRNO 603 65, CZECH REPUBLIC SN 0139-7893 J9 FOLIA ZOOL JI Folia Zool. PD SEP PY 2010 VL 59 IS 3 BP 192 EP 202 PG 11 WC Zoology SC Zoology GA 663CK UT WOS:000282860400003 ER PT J AU Moten, M AF Moten, Matthew TI Out of Order Strengthening the Political-Military Relationship SO FOREIGN AFFAIRS LA English DT Editorial Material AB The ouster of General Stanley McChrystal for his disparaging comments about civilian leaders does not suggest that U.S. political-military relations are in crisis. But it should remind the military's highest officers of the the need for, and the requirements of appropriate professional behavior. C1 USA, Washington, DC 20310 USA. RP Moten, M (reprint author), USA, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU COUNC FOREIGN RELAT INC PI NEW YORK PA 58 E 68TH ST, NEW YORK, NY 10021 USA SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD SEP-OCT PY 2010 VL 89 IS 5 BP 2 EP + PG 8 WC International Relations SC International Relations GA 643YF UT WOS:000281336200001 ER PT J AU Morrison, C Miecznikowski, J Darcy, KM Dolce, JM Kandel, E Erwin, DO Liu, S Shepherd, L Cohn, D McMeekin, DS Block, AW Nowak, NJ Maxwell, L AF Morrison, Carl Miecznikowski, Jeffrey Darcy, Kathleen M. Dolce, Jean M. Kandel, Eugene Erwin, Deborah O. Liu, Song Shepherd, Lori Cohn, David McMeekin, D. Scott Block, AnneMarie W. Nowak, Norma J. Maxwell, Larry TI A GOG 210 ACGH Study of Gain at 1q23 in Endometrioid Endometrial Cancer in the Context of Racial Disparity and Outcome SO GENES CHROMOSOMES & CANCER LA English DT Article ID AFRICAN-AMERICAN; CHROMOSOMAL REGIONS; CARCINOMA; WOMEN; NUMBER; OVEREXPRESSION; ADENOCARCINOMA; MUTATIONS; INTERVAL; RACE AB The goal of this study was to identify recurrent regions of genomic gain or loss in endometrial cancer of the endometrioid type in the context of racial disparities in mortality for this disease. Array comparative genomic hybridization (aCGH) analysis was performed on 80 frozen primary tumors from the Gynecologic Oncology Group (GOG)-210 bank using the RPCI I9K BAC arrays. The 80 patients included 20 African American (AA) Stage I, 20 White (W) Stage I, 20 African American (AA) Stage IIIC/IV, and 20 White (W) Stage IIIC/IV. A separate subset of 220 endometrial cancers with outcome data was used for validation. A 1.6-Mbp region of gain at 1q23 was identified by aCGH in all AA patients and high grade W patients, but not W low grade patients. In the validation arm of 220 patients copy number gain at this region was validated using FISH and locus specific BACs. The number of AA patients in the validation arm was too small to confirm the aCGH association with racial disparity. Kaplan-Meier curves for survival showed a significant difference for gain at 1q23 versus no gain (log rank P = 0.0014). When subdivided into various groups of risk by stage and grade the survival curves showed a decreased survival for high grade and/or stage tumors, but not for low grade and/or stage endometrioid tumors. Univariate analyses for gain at 1q23 showed a significant association (P = 0.009) with survival. Multivariate analysis for gain at 1q23 did not show a significant association with survival (P = 0.14). (c) 2010 Wiley-Liss, Inc. C1 [Morrison, Carl] Roswell Pk Canc Inst, Dept Pathol, Pathol Resource Network, Div Mol Pathol, Buffalo, NY 14263 USA. [Miecznikowski, Jeffrey; Liu, Song; Shepherd, Lori] Roswell Pk Canc Inst, Dept Biostat, Buffalo, NY 14263 USA. [Miecznikowski, Jeffrey; Liu, Song; Shepherd, Lori] New York State Ctr Excellence Bioinformat & Life, Sch Publ Hlth & Hlth Profess, Buffalo, NY USA. [Miecznikowski, Jeffrey; Darcy, Kathleen M.] Roswell Pk Canc Inst, GOG Stat & Data Ctr, Buffalo, NY 14263 USA. [Erwin, Deborah O.] Roswell Pk Canc Inst, Off Canc Hlth Dispar Res Canc Prevent & Control, Buffalo, NY 14263 USA. [Cohn, David] Columbia Canc Council, Dept Gynecol Oncol, Columbus, OH USA. [Cohn, David] Ohio State Univ, Columbus, OH 43210 USA. [McMeekin, D. Scott] Univ Oklahoma, Hlth Sci Ctr, Dept Obstet & Gynecol, Oklahoma City, OK 73190 USA. [Block, AnneMarie W.] Roswell Pk Canc Inst, Dept Pathol, Clin Cytogenet Lab, Buffalo, NY 14263 USA. [Nowak, Norma J.] Roswell Pk Canc Inst, Microarray & Genom Facil, Buffalo, NY 14263 USA. [Nowak, Norma J.] SUNY Buffalo, Buffalo, NY 14260 USA. [Nowak, Norma J.] New York State Ctr Excellence Bioinformat & Life, Dept Sci & Technol, Buffalo, NY USA. [Maxwell, Larry] Walter Reed Army Med Ctr, Gynecol Dis Ctr, Washington, DC 20307 USA. RP Morrison, C (reprint author), Roswell Pk Canc Inst, Dept Pathol, Pathol Resource Network, Div Mol Pathol, Elm & Carlton St, Buffalo, NY 14263 USA. EM carl.morrison@roswellpark.org NR 29 TC 5 Z9 5 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1045-2257 J9 GENE CHROMOSOME CANC JI Gene Chromosomes Cancer PD SEP PY 2010 VL 49 IS 9 BP 791 EP 802 DI 10.1002/gcc.20782 PG 12 WC Oncology; Genetics & Heredity SC Oncology; Genetics & Heredity GA 630VH UT WOS:000280302500003 PM 20607851 ER PT J AU Keyser, EA Reed, BG Lowery, WJ Sundborg, MJ Winter, WE Ward, JA Leath, CA AF Keyser, Erin A. Reed, Beverly G. Lowery, William J. Sundborg, Michael J. Winter, William E., III Ward, John A. Leath, Charles A., III TI Hospice enrollment for terminally ill patients with gynecologic malignancies: Impact on outcomes and interventions SO GYNECOLOGIC ONCOLOGY LA English DT Article; Proceedings Paper CT 95th Annual Clinical Congress of the American-College-of-Surgeons/64th Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical Problems CY OCT 11-15, 2009 CL Chicago, IL SP Amer Coll Surg DE Gynecologic cancer; hospice; palliative care; recurrent cancer ID END-OF-LIFE; OVARIAN-CANCER; CARE; ONCOLOGY AB Objective. To determine survival and interventions for patients with non-curative gynecologic malignancies based on supportive care enrollment. Methods. An IRB approved retrospective review identified patients with recurrent/persistent gynecologic cancers from 2002 to 2008. Demographics, therapy, clinicopathologic data, hospice utilization, surgical/invasive procedures and survival were collected. Patients were considered hospice enrollees if they enrolled following recommendation from their provider (HOSPICE); however, patients that declined hospice when recommended were considered (NO HOSPICE), regardless if they ultimately received supportive care. Standard statistical tests including: t-test and Kaplan-Meier with Log Rank were used. Results. Eighty-one patients were identified: 29 patients (36%) NO HOSPICE and 52 (64%) HOSPICE. Mean age was 61. Most patients had ovarian cancer (54.3%), were white (61.7%) and had disease recurrence (72%). Patients utilized a median of 3 anti-neoplastic therapies (range 0-10) for recurrent or progressive/persistent disease. Median time receiving hospice care was 1 week for NO HOSPICE patients versus 8 weeks HOSPICE patients (p<0.0005). In a subset of patients with recurrent disease, median overall survival for NO HOSPICE patients was 9 months (95% CI 5.9-12.1 months) versus 17 months (95% CI 11.1-22.9 months) for HOSPICE patients (p = 0.002). NO HOSPICE patients were more likely to have a procedure performed (55% vs. 31%) within 4 weeks of their death, including the administration of chemotherapy OR 2.4 (95% CI 1.1-7.1, p = 0.036). Conclusions. While retrospective reviews evaluating hospice are challenging, our data suggest no detrimental impact on survival for hospice patients. Continued evaluation for patients at the end-of-life is necessary in order to optimize resource utilization. Published by Elsevier Inc. C1 [Keyser, Erin A.; Reed, Beverly G.; Lowery, William J.; Leath, Charles A., III] Brooke Army Med Ctr, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. [Sundborg, Michael J.] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC USA. [Winter, William E., III] NW Canc Specialists, Portland, OR USA. [Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Leath, CA (reprint author), Dept OB GYN, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Trey_Leath@yahoo.com OI Leath III, Charles/0000-0002-4034-6845 NR 9 TC 19 Z9 19 U1 1 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD SEP PY 2010 VL 118 IS 3 BP 274 EP 277 DI 10.1016/j.ygyno.2010.05.021 PG 4 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 641KK UT WOS:000281124000012 PM 20542319 ER PT J AU Theeler, BJ Flynn, FG Erickson, JC AF Theeler, Brett J. Flynn, Frederick G. Erickson, Jay C. TI Headaches After Concussion in US Soldiers Returning From Iraq or Afghanistan SO HEADACHE LA English DT Article DE mild traumatic brain injury; concussion; military; posttraumatic headache ID TRAUMATIC BRAIN-INJURY; CHRONIC POSTTRAUMATIC HEADACHE; UNITED-STATES; PREVALENCE; MIGRAINE; DISABILITY; INCREASES; MILITARY; VETERANS; FREEDOM AB Objectives.-To determine the prevalence, characteristics, impact, and treatment patterns of headaches after concussion in US Army soldiers returning from a deployment to Iraq or Afghanistan. Methods.-A cross-sectional study was conducted with a cohort of soldiers undergoing postdeployment evaluation during a 5-month period at the Madigan Traumatic Brain Injury Program at Et. Lewis, WA. All soldiers screening positive for a deployment-related concussion were given a 13-item headache questionnaire. Results.-A total of 1033 (19.6%) of 5270 returning soldiers met criteria for a deployment-related concussion. Among those with a concussion, 957 (97.8%) reported having headaches during the final 3 months of deployment. Posttraumatic headaches, defined as headaches beginning within I week after a concussion, were present in 361 (37%) soldiers. In total, 58% of posttraumatic headaches were classified as migraine. Posttraumatic headaches had a higher attack frequency than nontraumatic headaches, averaging 10 days per month. Chronic daily headache was present in 27% of soldiers with posttraumatic headache compared with 14% of soldiers with nontraumatic headache. Posttraumatic headaches interfered with duty performance in 37% of cases and caused more sick call visits compared with nontraumatic headache. In total, 78% of soldiers with posttraumatic headache used abortive medications, predominantly over-the-counter analgesics, and most perceived medication as effective. Conclusions.-More than 1 in 3 returning military troops who have sustained a deployment-related concussion have headaches that meet criteria for posttraumatic headache. Migraine is the predominant headache phenotype precipitated by a concussion during military deployment. Compared with headaches not directly attributable to head trauma, posttraumatic headaches are associated with a higher frequency of headache attacks and an increased prevalence of chronic daily headache. C1 [Theeler, Brett J.] USA, Med Corps, Neurol Serv, William Beaumont Army Med Ctr,Dept Med, Ft Bliss, TX USA. [Flynn, Frederick G.] Madigan Traumat Brain Injury Program, Ft Lewis, WA USA. [Erickson, Jay C.] USA, Med Corps, Neurol Serv, Madigan Army Med Ctr,Dept Med, Ft Lewis, WA USA. RP Theeler, BJ (reprint author), USA, Med Corps, Neurol Serv, William Beaumont Army Med Ctr,Dept Med, Ft Bliss, TX USA. FU Uniformed Services University of the Health Sciences FX The Comprehensive National Neuroscience Program at the Uniformed Services University of the Health Sciences. NR 32 TC 49 Z9 49 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0017-8748 J9 HEADACHE JI Headache PD SEP PY 2010 VL 50 IS 8 BP 1262 EP 1272 DI 10.1111/j.1526-4610.2010.01700.x PG 11 WC Clinical Neurology SC Neurosciences & Neurology GA 645RU UT WOS:000281483200003 PM 20553333 ER PT J AU Ivanov, VI Yu, PL Baras, JS AF Ivanov, Vladimir I. Yu, Paul L. Baras, John S. TI Securing the communication of medical information using local biometric authentication and commercial wireless links SO HEALTH INFORMATICS JOURNAL LA English DT Article; Proceedings Paper CT 14th International Symposium for Health Information Management Research (ISHIMR 2009) CY OCT 16-18, 2009 CL Univ Kalmar, Kalmar, SWEDEN SP Univ Sheffield, Ctr Hlth Information Management Res HO Univ Kalmar DE authentication; biometrics; communication; cryptography; physical layer AB Medical information is extremely sensitive in nature - a compromise, such as eavesdropping or tampering by a malicious third party, may result in identity theft, incorrect diagnosis and treatment, and even death. Therefore, it is important to secure the transfer of medical information from the patient to the recording system. We consider a portable, wireless device transferring medical information to a remote server. We decompose this problem into two sub-problems and propose security solutions to each of them: ( 1) to secure the link between the patient and the portable device, and ( 2) to secure the link between the portable device and the network. Thus we push the limits of the network security to the edge by authenticating the user using their biometric information; authenticating the device to the network at the physical layer; and strengthening the security of the wireless link with a key exchange mechanism. The proposed authentication methods can be used for recording the readings of medical data in a central database and for accessing medical records in various settings. C1 [Ivanov, Vladimir I.; Baras, John S.] Univ Maryland, College Pk, MD 20742 USA. [Yu, Paul L.] USA, Res Lab, Adelphi, MD USA. RP Baras, JS (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM baras@umd.edu NR 31 TC 2 Z9 2 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1460-4582 J9 HEALTH INFORM J JI Health Inform. J. PD SEP PY 2010 VL 16 IS 3 BP 211 EP 223 DI 10.1177/1460458210377482 PG 13 WC Health Care Sciences & Services; Medical Informatics SC Health Care Sciences & Services; Medical Informatics GA 656XD UT WOS:000282373500006 PM 20889851 ER PT J AU Harrison, SA Rossaro, L Hu, KQ Patel, K Tillmann, H Dhaliwal, S Torres, DM Koury, K Goteti, VS Noviello, S Brass, CA Albrecht, JK McHutchison, JG Sulkowski, MS AF Harrison, Stephen A. Rossaro, Lorenzo Hu, Ke-Qin Patel, Keyur Tillmann, Hans Dhaliwal, Sandeep Torres, Dawn M. Koury, Kenneth Goteti, Venkata S. Noviello, Stephanie Brass, Clifford A. Albrecht, Janice K. McHutchison, John G. Sulkowski, Mark S. TI Serum Cholesterol and Statin Use Predict Virological Response to Peginterferon and Ribavirin Therapy SO HEPATOLOGY LA English DT Article ID HEPATITIS-C VIRUS; GENOTYPE 1B; COMBINATION THERAPY; JAPANESE PATIENTS; RNA REPLICATION; PEGYLATED INTERFERON; COINFECTED PATIENTS; LIPOPROTEIN LEVELS; FATTY-ACIDS; PPAR-ALPHA AB Elevated low-density lipoprotein (LDL) levels and statin use have been associated with higher sustained virological response (SVR) rates in patients receiving chronic hepatitis C therapy. However, these relationships have not been well characterized in randomized controlled trials. Furthermore, little is known about the relationship between high-density lipoprotein (HDL) and virological response. To determine whether baseline LDL or HDL levels and statin use affect SVR rates, we retrospectively evaluated the IDEAL (Individualized Dosing Efficacy Versus Flat Dosing to Assess Optimal Pegylated Interferon Therapy) trial, in which 3070 treatment-naive, hepatitis C virus (HCV) genotype 1 infected patients were treated for up to 48 weeks in one of the following arms: (1) peginterferon (PEG-IFN) alfa-2b at 1.5 mu g/kg/week with ribavirin (RBV) at 800 to 1400 mg/day, (2) PEG-IFN alfa-2b at 1.0 mu g/kg/week with RBV at 800 to 1400 mg/day, or (3) PEG-IFN alfa-2a at 180 mu g/week with RBV at 1000 to 1200 mg/day. Virological responses were assessed by pretreatment statin use and baseline elevated LDL levels (>= 130 mg/dL) or low HDL levels (<40 mg/dL for men and <50 mg/dL for women). In 1464 patients with baseline elevated LDL levels or low HDL levels, the SVR rate was significantly higher than that in patients with normal levels (44.9% versus 34.0%, P < 0.001). In 66 patients receiving a statin pretreatment, the SVR rate was higher than the rate of those not receiving it (53.0% versus 39.3%, P = 0.02). In a multivariate logistic regression analysis using the stepwise selection method with baseline characteristics, a high LDL level [odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.4-1.8, P < 0.001], a low HDL level (OR = 0.5, 95% CI = 0.3-0.8, P = 0.004), and statin use (OR = 2.0, 95% CI = 1.1-3.7, P = 0.02) were independently associated with SVR. Conclusion: Baseline elevated LDL levels or low HDL levels and pre-emptive statin usage were associated with higher SVR rates. Prospective studies may be considered to explore the biological impact of these factors on HCV RNA replication and treatment response. (HEPATOLOGY 2010;52:864-874) C1 [Harrison, Stephen A.; Torres, Dawn M.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. [Rossaro, Lorenzo; Dhaliwal, Sandeep] Univ Calif Davis Hlth Syst, Sacramento, CA USA. [Hu, Ke-Qin] Univ Calif Irvine, Med Ctr, Orange, CA USA. [Patel, Keyur; Tillmann, Hans; McHutchison, John G.] Duke Univ, Duke Clin Res Inst, Durham, NC USA. [Patel, Keyur; Tillmann, Hans; McHutchison, John G.] Duke Univ, Div Gastroenterol, Durham, NC USA. [Koury, Kenneth; Goteti, Venkata S.; Noviello, Stephanie; Brass, Clifford A.; Albrecht, Janice K.] Schering Plough Res Inst, Whitehouse Stn, NJ USA. [Sulkowski, Mark S.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil FU Idera Pharmaceutical; Medtronic; Osiris Therapeutics; Three Rivers Pharmaceuticals; ViroChem Pharma; Merck; Genentech; Vertex; Roche FX Dr. McHutchison received grants and is a consultant for Abbott Laboratories, Biolex Therapeutics, GlaxoSmithKline, GlobeImmune, Hoffmann-La Roche, Human Genome Sciences, Intarcia Therapeutics, Merck, Novartis, Pfizer, Pharmassest, Schering-Plough, Gilead, and Vertex. He received grants from Idera Pharmaceutical, Medtronic, Osiris Therapeutics, Three Rivers Pharmaceuticals, ViroChem Pharma. He also a consultant for Anadys, Alnylam, Epiphany Biosciences, ItheRx, National Genetics, One Pharmaceuticals, Santaris, Takeda, and United Therapeutics. Dr. Rossaro is a consultant for, is on the speakers' bureau of received grants from, and holds intellectual property rights for Genentech, Novartis, and Merck. He is a consultant for, is on the speakers' bureau of and holds intellectual property rights fir Three Rivers. Dr. Harrison is on the speakers' bureau of Bristol-Myers Squibb. Dr Hu is on the speakers' bureau of and received grants from, Merck and Genentech. He also received grants from Vertex. Dr. Koury owns stock in Merck. Dr. Noviello owns stock in and is a consultant for Merck. Dr. Sulkowski advises and received grants from Merck, Roche, and Genentech. NR 40 TC 91 Z9 95 U1 1 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD SEP PY 2010 VL 52 IS 3 BP 864 EP 874 DI 10.1002/hep.23787 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 645AJ UT WOS:000281423000009 PM 20568303 ER PT J AU Yang, Y Blum, RS Sadler, BM AF Yang, Yang Blum, Rick S. Sadler, Brian M. TI A Distributed and Energy-Efficient Framework for Neyman-Pearson Detection of Fluctuating Signals in Large-Scale Sensor Networks SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article DE Distributed routing; distributed scheduling; Kullback-Leibler distance; Neyman-Pearson criterion; signal detection; wireless sensor networks AB To address the challenges inherent to a problem of practical interest - of Neyman-Pearson detection of fluctuating radar signals using wireless sensor networks, we propose in this paper a distributed and energy-efficient framework. Such framework is scalable with respect to the network size, and is able to greatly reduce the dependence on the central fusion center. It assumes a clustering infrastructure, and addresses signal processing and communications related issues arising from different layers. This framework includes a distributed scheduling protocol and a distributed routing protocol, which enable sensor nodes to make their own decisions about information transmissions, without requiring the knowledge of the network global information. In this framework, energy efficiency manifests itself at different network layers in a distributed fashion, and a balance between the detection performance and the energy efficiency is also attained. C1 [Yang, Yang; Blum, Rick S.] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. [Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Yang, Y (reprint author), Lehigh Univ, Dept Elect & Comp Engn, 19 Mem Dr W, Bethlehem, PA 18015 USA. EM yay204@lehigh.edu; rblum@ece.lehigh.edu; bsadler@arl.army.mil FU Air Force Research Laboratory [FA9550-09-1-0576]; National Science Foundation [CCF-0829958]; U.S. Army Research Office [W911NF-08-1-0449] FX This material is based on research supported by the Air Force Research Laboratory under agreement FA9550-09-1-0576, by the National Science Foundation under Grant CCF-0829958, and by the U.S. Army Research Office under Grant W911NF-08-1-0449. NR 20 TC 14 Z9 15 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 EI 1558-0008 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD SEP PY 2010 VL 28 IS 7 BP 1149 EP 1158 DI 10.1109/JSAC.2010.100919 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 667GO UT WOS:000283181200019 ER PT J AU Damarla, T Kaplan, LM Whipps, GT AF Damarla, Thyagaraju Kaplan, Lance M. Whipps, Gene T. TI Sniper Localization Using Acoustic Asynchronous Sensors SO IEEE SENSORS JOURNAL LA English DT Article DE Cramer-Rao bound (CRB); muzzle blast; networked sensors; shock wave; sniper localization ID SYSTEM AB This paper describes a novel sniper localization method for a network of acoustic sensors. This approach relies only on the time-difference-of-arrival (TDOA) between the muzzle blast and shock wave from multiple single acoustic sensor nodes, as opposed to an array of microphones, relaxing the need for precise time synchronization across the network. This method is also best suited where an array of sensors, on a per-node basis, is not feasible. Results of the sniper localization algorithm using data collected in a field are presented here. Derivation of the Cramer-Rao bound is presented, and the results of the algorithm are compared with the bound. RP Damarla, T (reprint author), USA, RDRL SES A, Res Lab, Adelphi, MD 20783 USA. EM thyagaraju.damarla@us.army.mil; lance.m.kaplan@us.army.mil; gene.whipps@us.army.mil NR 14 TC 24 Z9 24 U1 3 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD SEP PY 2010 VL 10 IS 9 BP 1469 EP 1478 DI 10.1109/JSEN.2010.2045496 PG 10 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 659HC UT WOS:000282556600001 ER PT J AU Mirotznik, MS Good, BL Ransom, P Wikner, D Mait, JN AF Mirotznik, Mark S. Good, Brandon L. Ransom, Paul Wikner, David Mait, Joseph N. TI Broadband Antireflective Properties of Inverse Motheye Surfaces SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Antireflection; effective medium; millimeter wave; rigorous couple wave; subwavelength gratings ID COUPLED-WAVE ANALYSIS; MILLIMETER-WAVE; BINARY GRATINGS; IMPLEMENTATION; FORMULATION; DESIGN AB A new method for synthesizing broadband antireflective (AR) surfaces at microwave and millimeter wave frequencies is demonstrated. The AR surface, we call an inverse motheye, was formed by machining a multi-layer grating of subwavelength circular holes into a non-absorptive dielectric. This created low reflected energies (< -30 dB) over reasonably large bandwidths and incidence angles. An optimization algorithm, based on a direct pattern search, integrated with a rigorous electromagnetic model was used to design the grating geometries. Experimental results are provided at Ka-band demonstrating the validity of the method. C1 [Mirotznik, Mark S.; Good, Brandon L.] Univ Delaware, Newark, DE 19716 USA. [Mirotznik, Mark S.; Good, Brandon L.; Ransom, Paul] USN, Ctr Surface Warfare, Carderock Div, Bethesda, MD 20817 USA. [Ransom, Paul] Catholic Univ Amer, Washington, DC 20064 USA. [Wikner, David; Mait, Joseph N.] USA, Res Lab, Adelphi, MD 20783 USA. RP Mirotznik, MS (reprint author), Univ Delaware, Newark, DE 19716 USA. EM mirotzni@ece.udel.edu; Brandon.good@navy.mil; paul.ransom@navy.mil; david.wikner@arl.army.mil; jmait@arl.army.mil NR 17 TC 18 Z9 19 U1 3 U2 17 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD SEP PY 2010 VL 58 IS 9 BP 2969 EP 2980 DI 10.1109/TAP.2010.2052575 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 667ZV UT WOS:000283238800021 ER PT J AU Cheng, SF Tom, K Pecht, M AF Cheng, Shunfeng Tom, Kwok Pecht, Michael TI Failure Precursors for Polymer Resettable Fuses SO IEEE TRANSACTIONS ON DEVICE AND MATERIALS RELIABILITY LA English DT Article DE Failure modes, mechanisms, and effects analysis (FMMEA); failure precursors, polymer positive temperature coefficient (PPTC); prognostics and health management (PHM); resettable fuse; trip ID PHYSICS-OF-FAILURE; HEALTH MANAGEMENT; CARBON-BLACK; PROGNOSTICS; COMPOSITES; ELECTRONICS; SYSTEMS AB Resettable fuses have been widely used in overcurrent or overtemperature circuit protection designs in computers, automotive circuits, telecommunications equipment, and medical devices. Abnormal behavior of a resettable fuse can damage a circuit. This paper identifies and experimentally assesses the failure precursor parameters of a polymer positive temperature coefficient resettable fuse. It is shown that the degradation of the resettable fuse can be monitored, detected, and predicted based on the monitoring of these precursor parameters. C1 [Cheng, Shunfeng] Univ Maryland, Ctr Adv Life Cycle Engn, Prognost & Hlth Management Lab, College Pk, MD 20742 USA. [Tom, Kwok] Army Res Lab, Adelphi, MD 20783 USA. [Pecht, Michael] City Univ Hong Kong, Prognost & Hlth Management Ctr, Kowloon, Hong Kong, Peoples R China. RP Cheng, SF (reprint author), Univ Maryland, Ctr Adv Life Cycle Engn, Prognost & Hlth Management Lab, College Pk, MD 20742 USA. EM chengsf@calce.umd.edu; kwok.tom@us.army.mil; pecht@calce.umd.edu OI Pecht, Michael/0000-0003-1126-8662 FU U.S. Army Research Laboratory; NASA FX This work was supported in part by the U.S. Army Research Laboratory and in part by NASA. NR 23 TC 8 Z9 8 U1 0 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-4388 EI 1558-2574 J9 IEEE T DEVICE MAT RE JI IEEE Trans. Device Mater. Reliab. PD SEP PY 2010 VL 10 IS 3 BP 374 EP 380 DI 10.1109/TDMR.2010.2053371 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 669ND UT WOS:000283356600010 ER PT J AU Keller, SD Palmer, WD Joines, WT AF Keller, Steven D. Palmer, W. Devereux Joines, William T. TI Digitally Driven Antenna for HF Transmission SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE Antenna; communication system; electrically small; HF; pulsewidth modulation; switching amplifier; VHF ID DIPOLE; AMPLIFIERS AB An electrically small antenna connected directly to a complementary pair of switching transistors is driven with a pulsewidth modulated HF signal, eliminating the requirement for a frequency-dependent impedance-matching network. The intrinsic reactance of the transmit and receive antennas acts as a filter to recover the HF signal from the digital pulse train. This is defined here as the digitally driven antenna architecture. A circuit simulator with broadband equivalent-circuit models for the transmit and receive antennas is used to predict the received signal in the time domain, and the expected received spectrum is calculated using Maxwell's equations and the fast Fourier transform. The simulated circuit is realized using a highly capacitive electrically small dipole antenna driven at 1 MHz with a 10-MHz reference signal on the pulsewidth modulator as the transmitter and a highly inductive 470-mu H ferrite-loaded loop as the receive antenna. The 1-MHz signal is clearly evident in the time-domain received signal on an oscilloscope, and also in the received spectrum, as observed on a spectrum analyzer. This demonstrates that indeed it may be possible to produce efficient radiation across a wide bandwidth from an electrically small antenna by driving the antenna directly with a digital pulse train. C1 [Keller, Steven D.; Joines, William T.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. [Palmer, W. Devereux] USA, Res Off, Res Triangle Pk, NC 27703 USA. RP Keller, SD (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM steven.keller4@us.army.mil; dev.palmer@us.army.mil; wtj@ee.duke.edu RI Palmer, William/E-2296-2012 FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-04-D-0001] FX Manuscript received January 15, 2010; revised May 16, 2010; accepted May 25, 2010. Date of publication August 16, 2010; date of current version September 10, 2010. This work was supported in part by the U.S. Army Research Laboratory and by the U.S. Army Research Office under Agreement W911NF-04-D-0001, Delivery Order 0003. NR 16 TC 3 Z9 3 U1 3 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD SEP PY 2010 VL 58 IS 9 BP 2362 EP 2367 DI 10.1109/TMTT.2010.2058553 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA 668EJ UT WOS:000283251100006 ER PT J AU Burke, P Du, C Herr, D Jensen, JO Lugli, P Radack, DJ Stroscio, M Swaminathan, V Towe, E Woodlard, DL AF Burke, Peter Du, Chunnel Herr, Daniel Jensen, James O. Lugli, Paolo Radack, Daniel J. Stroscio, Michael Swaminathan, Venkataraman Towe, Elias Woodlard, Dwight L. TI Device Concepts, Architectural Strategies, and Interfacing Methodologies for Nanoscale Sensor Systems SO IEEE TRANSACTIONS ON NANOTECHNOLOGY LA English DT Editorial Material C1 [Burke, Peter] Univ Calif Irvine, Irvine, CA 92717 USA. [Du, Chunnel] Chinese Acad Sci, Inst Opt & Elect, Beijing 100864, Peoples R China. [Herr, Daniel] SRC, Res Triangle Pk, NC USA. [Jensen, James O.] USA, Computat Chem Grp, ECBC, Edgewood, MD USA. [Jensen, James O.] USA, Ballist Res Lab, Edgewood, MD USA. [Jensen, James O.] USA, Standoff Detect Grp, Irvine, CA USA. [Jensen, James O.] USA, Pass Standoff Detect Team, Irvine, CA USA. [Lugli, Paolo] Tech Univ Munich, Munich, Germany. [Radack, Daniel J.] Inst Def Anal, Alexandria, VA USA. [Stroscio, Michael] Univ Illinois, Chicago, IL USA. [Swaminathan, Venkataraman] USA, Acoust & Networked Sensors Div, Armament Res & Dev Ctr, RDECOM, Picatinny Arsenal, NJ USA. [Towe, Elias] Carnegie Mellon Univ, Dept Elect & Comp Engn, Pittsburgh, PA 15213 USA. [Towe, Elias] Carnegie Mellon Univ, Dept Mat Sci & Engn, Pittsburgh, PA 15213 USA. [Woodlard, Dwight L.] USA, Res Lab, Res Off, Res Triangle Pk, NC USA. RP Burke, P (reprint author), Univ Calif Irvine, Irvine, CA 92717 USA. RI Burke, Peter/F-3308-2010 NR 0 TC 0 Z9 1 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-125X J9 IEEE T NANOTECHNOL JI IEEE Trans. Nanotechnol. PD SEP PY 2010 VL 9 IS 5 SI SI BP 523 EP 526 DI 10.1109/TNANO.2010.2072170 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Science & Technology - Other Topics; Materials Science; Physics GA 668DS UT WOS:000283249400001 ER PT J AU Gelmont, B Chen, YK Xie, Z Luo, Y Jensen, JO AF Gelmont, Boris Chen, Yikan Xie, Zhen Luo, Ying Jensen, James O. TI Stilbene and Its Derivatives for Multistate Spectral Sensing SO IEEE TRANSACTIONS ON NANOTECHNOLOGY LA English DT Article DE Multistate spectral sensing; stilbene; 3,4,5-trimethoxystilbene carboxamidopropane (TMS) ID DENSITY; PHOTOISOMERIZATION; EXCHANGE; DYNAMICS AB Terahertz (THz) region in the vibrational spectra of a certain molecule reveals the intramolecular vibrations between weakly bonded or nonbonded groups. Additional information can be acquired by photoinduced transitions between metastable states of the target agent. Different isomers of stilbene and its derivatives can be utilized in order to obtain the spectral "THz fingerprint" using multistate spectral-sensing technology. Also, stilbene and its derivatives are able to form "capping" with DNA, thus making them a very important covalent linker with DNA terminus to increase the fidelity of DNA duplexes as oligonucleotide hybridization probes. We study photoinduced transitions of stilbene and its derivatives and the change of vibrational spectra as a result of these transitions. All derivatives have vibrational frequencies in the THz region with a large difference in frequencies between two isomers. C1 [Gelmont, Boris; Chen, Yikan; Xie, Zhen] Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. [Luo, Ying] Triquint Semicond, Hillsboro, OR 97124 USA. [Jensen, James O.] USA, Edgewood Chem & Biol Ctr, Edgewood, MD 21010 USA. RP Gelmont, B (reprint author), Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. EM gb7k@virginia.edu; yc2r@virginia.edu; zx6e@virginia.edu; uva.ying.luo@gmail.com; jim.jensen@us.army.mil FU U.S. Army [W911NF-08-1-0111] FX This work was supported in part by U.S. Army under Contract W911NF-08-1-0111. The review of this paper was arranged by Associate Editor M. A. Stroscio. NR 23 TC 1 Z9 1 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-125X J9 IEEE T NANOTECHNOL JI IEEE Trans. Nanotechnol. PD SEP PY 2010 VL 9 IS 5 SI SI BP 558 EP 564 DI 10.1109/TNANO.2010.2050210 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Science & Technology - Other Topics; Materials Science; Physics GA 668DS UT WOS:000283249400007 ER PT J AU Bykhovski, AD Woolard, DL AF Bykhovski, Alexei D. Woolard, Dwight L. TI Hybrid Ab Initio/Empirical Modeling of the Conformations and Light-Induced Transitions in Stilbene-Derivatives Bonded to DNA SO IEEE TRANSACTIONS ON NANOTECHNOLOGY LA English DT Article DE Bioelectronic sensing; DNA; stilbene; terahertz (THz) ID ENERGETICS; TERAHERTZ AB Modeling and simulation techniques are presented, which are both physically accurate and computationally efficient for treating complex organic structures that have relevance to sensing and characterization, including structures with covalent bonding to biological (i.e., DNA) molecules. The theoretical study of large and complex biological molecular systems is very challenging because ab initio quantum mechanical methods are usually too computationally demanding and alternative empirical approaches are often insufficient for describing the internal interactions and dynamics. The goal of this research is to provide detailed insight into the molecular interaction mechanisms (e. g., terahertz (THz) frequency spectral absorption), which can be used to define novel types of bioelectronic-sensing devices. Therefore, a mixed ab initio/molecular mechanical-modeling approach is implemented and applied to the study of stilbene-DNA conjugates that offer switchable spectral characteristics that may be useful for detection and identification purposes. In particular, results are generated for two conformations of a TGCGCA-DNA duplex with trimethoxystilbene carboxamide (TMS) end capping that are confirmed by experimental data. The model is also used to derive the influences of DNA sequence and/or TMS orientation on the conformation, electronic states, and atomic vibrations of single-and doubled-stranded variants of the TGCGCA-DNA duplex. These results, which include very distinct absorption spectra in the THz to UV range, demonstrate that hybrid methodologies can bridge the gap in understanding electronic and atomic structure, and light-induced interactions in complex bioorganic systems. C1 [Bykhovski, Alexei D.; Woolard, Dwight L.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Woolard, Dwight L.] USA, Div Elect, Res Off, Res Triangle Pk, NC 27709 USA. RP Bykhovski, AD (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM abykhov@ncsu.edu; dwight.woolard@us.army.mil FU National Research Council FX This work was supported in part by the National Research Council through Senior Fellowship program in the area of Physics and Modeling of Terahertz Electronic Devices and Nanostructures. The review of this paper was arranged by Associate Editor M. A. Stroscio. NR 17 TC 3 Z9 3 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-125X J9 IEEE T NANOTECHNOL JI IEEE Trans. Nanotechnol. PD SEP PY 2010 VL 9 IS 5 SI SI BP 565 EP 574 DI 10.1109/TNANO.2010.2060349 PG 10 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Science & Technology - Other Topics; Materials Science; Physics GA 668DS UT WOS:000283249400008 ER PT J AU Zhang, WD Woolard, DL AF Zhang, Weidong Woolard, Dwight L. TI InAs/GaSb Broken-Gap Heterostructure Laser for Terahertz Spectroscopic Sensing Application SO IEEE TRANSACTIONS ON NANOTECHNOLOGY LA English DT Article DE Conduction band; heavy hole; heterostructure; InAs/GaSb; interband; lasing; nonradiative transitions ID ELECTRON-TRANSPORT AB A completely new type of solid-state laser device is presented that offers the potential for achieving significantly increased levels of terahertz (THz) frequency output power at relatively high operating temperatures. Specifically, a double-barrier GaSb/InAs/GaSb heterostructure device concept is introduced that simultaneously leverages resonant electron injection and interband tunneling electron depletion to realize electron-population inversion, while at the same time mitigating the scattering effects that degrade the lasing process. Here, the main innovations are the ability to spatially separate the upper and lower electron populations using the quantum confinement of the double-barrier conduction band well and the valence-band (VB) well (i.e., of the second barrier), respectively, and the depopulation of the VB well by heavy hole interband tunneling. A theoretical analysis of the radiative and nonradiative transition rates based upon a multiband Kane model formalism is used to confirm the large available optical gain and to estimate the lasing output power at very long wavelengths. Therefore, this study establishes the initial foundation for a solid-state THz laser that can provide significant levels of output power below 1 THz. Furthermore, the inherently high spectral purity and natural tunability offered by this novel laser technology will be instrumental in future spectroscopic analysis of nanoscale biological and/or organic systems that are well known to possess unique spectral signatures at very long wavelengths. C1 [Zhang, Weidong] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Woolard, Dwight L.] USA, Res Lab, Res Off, Res Triangle Pk, NC 27709 USA. RP Zhang, WD (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM wzhang5@ncsu.edu NR 15 TC 2 Z9 2 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-125X J9 IEEE T NANOTECHNOL JI IEEE Trans. Nanotechnol. PD SEP PY 2010 VL 9 IS 5 SI SI BP 575 EP 581 DI 10.1109/TNANO.2010.2048337 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Science & Technology - Other Topics; Materials Science; Physics GA 668DS UT WOS:000283249400009 ER PT J AU Jin, J Rothrock, L McDermott, PL Barnes, M AF Jin, Jeonghwan Rothrock, Ling McDermott, Patricia L. Barnes, Michael TI Using the Analytic Hierarchy Process to Examine Judgment Consistency in a Complex Multiattribute Task SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART A-SYSTEMS AND HUMANS LA English DT Article DE Analytic Hierarchy Process (AHP); framing effect; judgment consistency; multiattribute task ID DECISION-MAKING; BOUNDED RATIONALITY; SELECTION; DESIGN; CHOICE; RISK AB This paper investigates the impact of framing and time pressure on human judgment performance in a complex multiattribute judgment task. We focus on the decision process of human participants who must choose between pairwise alternatives in a resource-allocation task. We used the Analytic Hierarchy Process (AHP) to calculate the relative weights of the four alternatives (i.e., C(1), C(2), C(3), and C(4)) and the judgment consistency. Using the AHP, we examined two sets of hypotheses that address the impact of task conditions on the weight prioritization of choice alternatives and the internal consistency of the judgment behavior under varying task conditions. The experiment simulated the allocation of robotic assets across the battlefield to collect data about an enemy. Participants had to make a judgment about which asset to allocate to a new area by taking into account three criteria related to the likelihood of success. We manipulated the information frame and the nature of the task. We found that, in general, participants gave significantly different weights to the same alternatives under different frames and task conditions. Specifically, in terms of ln-transformed priority weights, participants gave significantly lower weights to C(2) and C(4) and higher weight to C(3) under gain frame than under loss frame, and also, under different task conditions (i.e., Tasks #1, #2, and #3), participants gave significantly higher weight to C(4) in Task #1, lower weights to C(1) and C(4), higher weight to C(3) in Task #2, and lower weight to C(3) in Task #3. Furthermore, we found that the internal consistency of the decision behavior was worse, first, in the loss frame than the gain frame and, second, under time pressure. Our methodology complements utility-theoretic frameworks by assessing judgment consistency without requiring the use of task-performance outcomes. This work is a step toward establishing a coherence criterion to investigate judgment under naturalistic conditions. The results will be useful for the design of multiattribute interfaces and decision aiding tools for real-time judgments in time-pressured task environments. C1 [Jin, Jeonghwan; Rothrock, Ling] Penn State Univ, Harold & Inge Marcus Dept Ind & Mfg Engn, University Pk, PA 16802 USA. [McDermott, Patricia L.] Alion Sci & Technol, Mclean, VA 22102 USA. [Barnes, Michael] USA, Res Lab, Ft Huachuca, AZ 85613 USA. RP Jin, J (reprint author), Penn State Univ, Harold & Inge Marcus Dept Ind & Mfg Engn, University Pk, PA 16802 USA. EM jzj110@psu.edu; lrothrock@psu.edu; pmcdermott@alionscience.com; michael.j.barnes@us.army.mil OI Rothrock, Ling/0000-0001-7614-5132 FU U.S. Army Research Laboratory; Alion Science and Technology FX Manuscript received May 28, 2008; revised May 3, 2009. Date of publication April 26, 2010; date of current version August 18, 2010. This work was supported in part by the U.S. Army Research Laboratory and in part by Alion Science and Technology. The views, opinions, and/or findings expressed in this paper are those of the author(s) and should not be construed as an official Department of the Army position, policy, or decision, unless so designated by other documentation. This paper was recommended by Associate Editor E. J. Bass. NR 43 TC 13 Z9 15 U1 3 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4427 J9 IEEE T SYST MAN CY A JI IEEE Trans. Syst. Man Cybern. Paart A-Syst. Hum. PD SEP PY 2010 VL 40 IS 5 SI SI BP 1105 EP 1115 DI 10.1109/TSMCA.2010.2045119 PG 11 WC Computer Science, Cybernetics; Computer Science, Theory & Methods SC Computer Science GA 666OW UT WOS:000283126300018 ER PT J AU Chandrahalim, H Bhave, SA Polcawich, RG Pulskamp, JS Kaul, R AF Chandrahalim, Hengky Bhave, Sunil A. Polcawich, Ronald G. Pulskamp, Jeffrey S. Kaul, Roger TI PZT Transduction of High-Overtone Contour-Mode Resonators SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article AB This paper presents the Butterworth-van Dyke model and quantitative comparison that explore the design space of lead zirconate titanate-only (PZT) and PZT on 3-, 5-, and 10-mu m single-crystal silicon (SCS) high-overtone width-extensional mode (WEM) resonators with identical lateral dimensions for incorporation into radio frequency microelectro-mechanical systems (RF MEMS) filters and oscillators. A novel fabrication technique was developed to fabricate the resonators with and without a silicon carrier layer using the same mask set on the same wafer. The air-bridge metal routings were implemented to carry electrical signals while avoiding large capacitances from the bond-pads. We theoretically derived and experimentally measured the correlation of motional impedance (R(X)), quality factor (Q), and resonance frequency (f) with the resonators' silicon layer thickness (t(Si)) up to frequencies of operation above 1 GHz. C1 [Chandrahalim, Hengky; Bhave, Sunil A.] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY USA. [Polcawich, Ronald G.; Pulskamp, Jeffrey S.] USA, Res Lab, Adelphi, MD USA. RP Chandrahalim, H (reprint author), Swiss Fed Inst Technol, Micro & Nanosyst Lab, Zurich, Switzerland. EM hengky.chandrahalim@micro.mavt.ethz.ch RI Chandrahalim, Hengky/F-1475-2016 OI Chandrahalim, Hengky/0000-0003-1930-1359 NR 6 TC 5 Z9 5 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD SEP PY 2010 VL 57 IS 9 BP 2035 EP 2041 DI 10.1109/TUFFC.2010.1651 PG 7 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 669OI UT WOS:000283359700015 PM 20875993 ER PT J AU Miyata, T Harakuni, T Tsuboi, T Sattabongkot, J Kohama, H Tachibana, M Matsuzaki, G Torii, M Arakawa, T AF Miyata, Takeshi Harakuni, Tetsuya Tsuboi, Takafumi Sattabongkot, Jetsumon Kohama, Hideyasu Tachibana, Mayumi Matsuzaki, Goro Torii, Motomi Arakawa, Takeshi TI Plasmodium vivax Ookinete Surface Protein Pvs25 Linked to Cholera Toxin B Subunit Induces Potent Transmission-Blocking Immunity by Intranasal as Well as Subcutaneous Immunization SO INFECTION AND IMMUNITY LA English DT Article ID VACCINE CANDIDATE; MALARIA VACCINES; FALCIPARUM; ANTIBODIES; PFS25; TRIAL; MICE; PERSPECTIVES; ERADICATION; ADJUVANTS AB The nontoxic cholera toxin B subunit (CTB) was evaluated as a potential delivery molecule for the Plasmodium vivax ookinete surface protein, Pvs25. Recombinant Pvs25 was expressed as a secreted protein in the yeast Pichia pastoris, as a mixture of isoforms including multimers and the A and B monomers. The A isoform with the presumed native protein fold was the most abundant, accounting for more than 40% of all expressed protein. The molecularly uniform A isoform was chemically conjugated to CTB via its primary amines, and the fusion protein, retaining GM1-ganglioside affinity, was administered to BALB/c mice by the subcutaneous (s.c.) or intranasal (i.n.) route. Immunization of mice with conjugated Pvs25 without supplemental adjuvant induced antisera that specifically recognized P. vivax ookinetes in vitro. Furthermore, the antisera, when mixed with parasitized blood isolated from P. vivax patients from Thailand, was found to reduce parasite transmission to mosquitoes, conferring a 93 to 98% (s.c.) or a 73 to 88% (i.n.) decrease in oocyst number. Unconjugated Pvs25 alone conferred only a 23 to 60% (s.c.) or a 0 to 6% (i.n.) decrease in oocyst number. Coadministration of extraneous adjuvants, however, further enhanced the vaccine efficacy up to complete blockade. Taken together, we conclude that a weakly immunogenic Pvs25 by itself, when linked to CTB, transforms into a potent transmission-blocking antigen in both i.n. and s.c. routes. In addition, the present study is, to the best of our knowledge, the first demonstration of the immune potentiating function of CTB for a vaccine antigen delivered by the s.c. route. C1 [Miyata, Takeshi; Harakuni, Tetsuya; Kohama, Hideyasu; Matsuzaki, Goro; Arakawa, Takeshi] Univ Ryukyus, Trop Biosphere Res Ctr, COMB, Dept Trop Infect Dis,Mol Microbiol Grp, Okinawa 9030213, Japan. [Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Tachibana, Mayumi; Torii, Motomi] Ehime Univ, Grad Sch Med, Dept Mol Parasitol, Toon, Ehime 7910295, Japan. [Matsuzaki, Goro; Arakawa, Takeshi] Univ Ryukyus, Grad Sch Med, Div Host Def & Vaccinol, Okinawa 9030213, Japan. RP Arakawa, T (reprint author), Univ Ryukyus, Trop Biosphere Res Ctr, COMB, Dept Trop Infect Dis,Mol Microbiol Grp, 1 Senbaru, Okinawa 9030213, Japan. EM tarakawa@comb.u-ryukyu.ac.jp FU Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [19406009, 20590425, 21022034]; Okinawa Industry Promotion Public Corp. (Naha, Okinawa, Japan); NEKKEN FX This study was supported by the following grants: the Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Grants-in-Aid for Scientific Research (19406009 and 20590425) and Scientific Research on Priority Areas (21022034) from MEXT; a grant from The Okinawa Industry Promotion Public Corp. (Naha, Okinawa, Japan); and a Cooperative Research Grant from NEKKEN, 2010. NR 30 TC 19 Z9 22 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 2010 VL 78 IS 9 BP 3773 EP 3782 DI 10.1128/IAI.00306-10 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 639PM UT WOS:000280986700013 PM 20584978 ER PT J AU Johnson, E Dao, T Kan, R AF Johnson, E. Dao, T. Kan, R. TI TEMPORAL AND CELLULAR CHEMOKINE EXPRESSION FOLLOWING PROLONGED SOMAN-INDUCED STATUS EPILEPTICUS IN RATS SO INFLAMMATION RESEARCH LA English DT Meeting Abstract CT 16th International Conference of the Inflammation-Research-Association CY 2008 CL Chantilly, VA SP Inflammation Res Assoc C1 [Johnson, E.; Dao, T.; Kan, R.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIRKHAUSER VERLAG AG PI BASEL PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND SN 1023-3830 J9 INFLAMM RES JI Inflamm. Res. PD SEP PY 2010 VL 59 SU 3 BP S290 EP S290 PG 1 WC Cell Biology; Immunology SC Cell Biology; Immunology GA 649JS UT WOS:000281765500027 ER PT J AU van Niekerk, W Markell, KW Cancio, L AF van Niekerk, W. Markell, K. W. Cancio, L. TI ABDOMINAL SURGERY IN BURN PATIENTS: THE RISE OF ABDOMINAL COMPARTMENT SYNDROME HAS NOT ECLIPSED DEAD GUT SO INTENSIVE CARE MEDICINE LA English DT Meeting Abstract CT 23rd Annual Meeting of the European-Society-of-Intensive-Care-Medicine CY OCT 09-13, 2010 CL Barcelona, SPAIN SP European Soc Intens Care Med C1 [van Niekerk, W.] Broomfield Hosp, St Andrews Ctr Burns & Plast Surg, Chelmsford, Essex, England. [Markell, K. W.] Brooke Army Med Ctr, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Cancio, L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0342-4642 J9 INTENS CARE MED JI Intensive Care Med. PD SEP PY 2010 VL 36 SU 2 MA 1180 BP S382 EP S382 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 648GS UT WOS:000281679501225 ER PT J AU Harvey, S Dixon, M AF Harvey, Steve Dixon, Melissa TI Biological hydrogen production: Simultaneous saccharification and fermentation with nitrogen and phosphorus removal from wastewater effluent SO INTERNATIONAL JOURNAL OF HYDROGEN ENERGY LA English DT Article DE Hydrogen; Paper; Wastewater; Nitrogenase; Hydrogenase ID FIXATION AB A simple anaerobic biodegradation process using wastewater treatment plant (WWTP) effluent, shredded paper, and a purge of nitrogen gas was used to produce hydrogen and simultaneously capture nitrogen and phosphorus. Two reactor configurations, a sequencing batch reactor (SBR) and a classic batch reactor (CBR) were tested as simultaneous saccharification and fermentation reactors (enzymatic hydrolysis and fermentation in one tank). The CBR demonstrated greater stability of hydrogen production and simplicity of operation, while the SBR provided better nitrogen and phosphorus removal efficiencies. Nuclear magnetic resonance analyses showed acetic acid to be the main product from both reactors. Optimal CBR conditions were found to be pH 5, 4 g/L loading, 0.45 ml/g Accellerase 1500, and 38 degrees C. Experiments with an argon purge in place of nitrogen and with ammonium chloride spiking suggested that hydrogenase and nitrogenase enzymes contributed similarly to hydrogen production in the cultures. Analysis of a single fermentation showed that hydrogen production occurred relatively early in the course of TOC removal, and that follow-on treatments might extract more energy from the products. Published by Elsevier Ltd on behalf of Professor T. Nejat Veziroglu. C1 [Harvey, Steve; Dixon, Melissa] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Harvey, S (reprint author), USA, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd,Bldg E3160, Aberdeen Proving Ground, MD 21010 USA. EM Steve.Harvey@us.army.mil; melissa.dixon4@us.army.mil FU U.S. Army Environmental Quality Basic Research and Development Program; U.S. Army Edgewood Chemical Biological Center Inhouse Laboratory Independent Research program FX The authors gratefully acknowledge Dr. George Hondrogiannis and David Cullinan for expert NMR analyses of the bioreactor samples, and Dr. Vipin Rastogi for critical comments on the manuscript. Funding for this work was provided by the U.S. Army Environmental Quality Basic Research and Development Program and the U.S. Army Edgewood Chemical Biological Center Inhouse Laboratory Independent Research program. NR 15 TC 3 Z9 3 U1 2 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-3199 J9 INT J HYDROGEN ENERG JI Int. J. Hydrog. Energy PD SEP PY 2010 VL 35 IS 18 SI SI BP 9611 EP 9617 DI 10.1016/j.ijhydene.2010.06.042 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels SC Chemistry; Electrochemistry; Energy & Fuels GA 656PA UT WOS:000282347500010 ER PT J AU Taylor, JB Gerlach, RC Herold, RW Bisch, FC Dixon, DR AF Taylor, John B. Gerlach, Robert C. Herold, Robert W. Bisch, Frederick C. Dixon, Douglas R. TI A Modified Tensionless Gingival Grafting Technique Using Acellular Dermal Matrix SO INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY LA English DT Article ID CONNECTIVE-TISSUE GRAFT; ROOT COVERAGE; RECESSION; FLAP AB Conventional surgical procedures designed for autogenous tissue material may not be appropriate when using acellular dermal matrix (ADM) for the treatment of gingival recessions. This article describes a new surgical technique that addresses the unique and sensitive aspects of ADM specifically to improve esthetic outcomes and gain increased clinical predictability when treating Miller Class I and II gingival recession defects. In this paper, a root coverage case is described and the specific steps and rationale for this new technique are explained. This technique has been predictable clinically, with results comparable to those achieved using autogenous tissue. (Int J Periodontics Restorative Dent 2010; 30: 513-521.) C1 [Taylor, John B.] NE Georgia Periodont, Gainesville, GA USA. [Taylor, John B.] Ctr Dent Implants, Gainesville, GA USA. [Gerlach, Robert C.; Herold, Robert W.; Bisch, Frederick C.; Dixon, Douglas R.] USA, Adv Educ Program Periodont, Ft Gordon, GA USA. RP Taylor, JB (reprint author), POB 908505,691 Lanier Pk Dr, Gainesville, GA 30501 USA. EM implantcenter@bellsouth.net NR 26 TC 2 Z9 4 U1 0 U2 1 PU QUINTESSENCE PUBLISHING CO INC PI HANOVER PARK PA 4350 CHANDLER DRIVE, HANOVER PARK, IL 60133 USA SN 0198-7569 J9 INT J PERIODONT REST JI Int. J. Periodontics Restor. Dent. PD SEP-OCT PY 2010 VL 30 IS 5 BP 513 EP 521 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 653BE UT WOS:000282056500009 PM 20814605 ER PT J AU Clayton, JD AF Clayton, J. D. TI Modeling finite deformations in trigonal ceramic crystals with lattice defects SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article DE Twinning; Dislocations; Crystal plasticity; Ceramic material; Alumina ID STACKING-FAULT ENERGY; STRAIN GRADIENT PLASTICITY; AL2O3 SINGLE-CRYSTALS; SAPPHIRE ALPHA-AL2O3; BASAL SLIP; DISLOCATION DENSITY; TEXTURE DEVELOPMENT; ANISOTROPIC CRYSTALS; NONLINEAR ELASTICITY; ZIRCONIUM ALLOYS AB A model is developed for thermomechanical behavior of defective, low-symmetry ceramic crystals such as a-corundum. Kinematics resolved are nonlinear elastic deformation, thermal expansion, dislocation glide, mechanical twinning, and residual lattice strains associated with eigenstress fields of defects such as dislocations and stacking faults. Multiscale concepts are applied to describe effects of twinning on effective thermoelastic properties. Glide and twinning are thermodynamically irreversible, while free energy accumulates with geometrically necessary dislocations associated with strain and rotation gradients, statistically stored dislocations, and twin boundaries. The model is applied to describe single crystals of corundum. Hardening behaviors of glide and twin systems from the total density of dislocations accumulated during basal slip are quantified for pure and doped corundum crystals. Residual lattice expansion is predicted from nonlinear elasticity and dislocation line and stacking fault energies. Published by Elsevier Ltd. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil RI Clayton, John/C-7760-2009 NR 145 TC 9 Z9 9 U1 2 U2 20 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0749-6419 EI 1879-2154 J9 INT J PLASTICITY JI Int. J. Plast. PD SEP PY 2010 VL 26 IS 9 SI SI BP 1357 EP 1386 DI 10.1016/j.ijplas.2010.01.014 PG 30 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA 651HN UT WOS:000281918700005 ER PT J AU Wang, X Pan, E Chung, PW AF Wang, X. Pan, E. Chung, P. W. TI Misfit dislocation dipoles in wire composite solids SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article DE Wire composite; Misfit dislocation dipole; Equilibrium position ID CRYSTAL PLASTICITY; ESHELBY TWIST; CORE-SHELL; NANOWIRES; MODEL AB Developed in this note is a theoretical model describing the mobility of a misfit screw dislocation dipole in a wire composite consisting of a stiff cylindrical substrate covered by a soft co-axial cylindrical film. A critical value of the film thickness, which is a function of the parameter measuring the stiffness of the film with respect to the substrate, is identified. It is observed that: (i) there exist two equilibrium positions of the misfit dislocation dipole (one stable and the other one unstable) when the film is thicker than the critical value; (ii) the two equilibrium positions of the misfit dislocation dipole converge to a single saddle point equilibrium position which is neither stable nor unstable when the thickness of the film is at the critical value; (iii) there exists no equilibrium position of the misfit dislocation dipole when the thickness of the film is below the critical value. These features could be useful to the design of wire composites and to the dislocation-related plasticity analysis. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Pan, E.] Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. [Wang, X.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Chung, P. W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pan, E (reprint author), Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. EM pan2@uakron.edu RI Pan, Ernian/F-4504-2011 OI Pan, Ernian/0000-0001-6640-7805 FU Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO) [W911NF-06-2-0038] FX This work was partially supported by Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO) under the grant W911NF-06-2-0038. NR 19 TC 12 Z9 14 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0749-6419 EI 1879-2154 J9 INT J PLASTICITY JI Int. J. Plast. PD SEP PY 2010 VL 26 IS 9 SI SI BP 1415 EP 1420 DI 10.1016/j.ijplas.2010.03.004 PG 6 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA 651HN UT WOS:000281918700008 ER PT J AU Berger, MT Reese, JY AF Berger, Mark T. Reese, Justin Y. TI From nation-states in conflict to conflict in nation-states: The United States of America and nation building from South Vietnam to Afghanistan SO INTERNATIONAL POLITICS LA English DT Article DE nation building; nation-state; security; development; geopolitics; failed state ID FAILED STATES AB This article engages with the latest (post-Cold War) debate about the theory and practice of nation building (state building). This is linked to a discussion of the shift in US foreign policy towards Afghanistan relative to Iraq between late 2008 and late 2009. Afghanistan is currently a major focus of nation building efforts and counter-insurgency programs led by the United States of America. Meanwhile, the discussion here ranges from South Vietnam to Colombia, Iraq and Afghanistan, and explores some of the ghosts that now haunt the US presence in Afghanistan 9 years on from the start Operation Enduring Freedom at the end of 2001. We argue that the possibility of successful nation building in Afghanistan is both far-fetched and far-off. In fact, what is required is the reorientation and reduction (even termination) of Washington and its allies' direct commitment to Kabul. Washington and its allies should focus on a grand strategy for the Middle East and Asia that attaches far less importance to Afghanistan. This should occur in the context of understanding the history of the emergence, universalization and contemporary crisis of the nation-state system. Nowhere are the limits of the nation-state system and the failure of nation building more apparent today than in Afghanistan. In this context a whole new approach to questions of war, peace and progress is in order. The comprehensive elaboration of a new security-development framework is beyond the scope of this article, but we conclude by elaborating some of the main elements of a new framework: this will include a point of departure for research and policy to move beyond the current crisis of the nation-state system and nation building. International Politics (2010) 47, 451-471. doi:10.1057/ip.2010.21 C1 [Berger, Mark T.] USN, Postgrad Sch, Monterey, CA USA. [Berger, Mark T.] Univ British Columbia, Kelowna, BC, Canada. [Reese, Justin Y.] USA, Airborne Div 101, Washington, DC USA. RP Berger, MT (reprint author), USN, Postgrad Sch, Monterey, CA USA. EM mtberger@nps.edu; reesejy@gmail.com NR 57 TC 0 Z9 0 U1 2 U2 17 PU PALGRAVE MACMILLAN LTD PI BASINGSTOKE PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND SN 1384-5748 J9 INT POLITICS JI Int. Polit. PD SEP PY 2010 VL 47 IS 5 BP 451 EP 471 DI 10.1057/ip.2010.21 PG 21 WC International Relations; Political Science SC International Relations; Government & Law GA 660EL UT WOS:000282622700001 ER PT J AU Ender, M AF Ender, Morten TI War in Iraq: Planning and Execution. SO INTERNATIONAL SOCIOLOGY LA English DT Book Review DE Afghanistan; cyber-war; insurgency; Iraqi military; Iraq War; leadership failure C1 [Ender, Morten] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Ender, M (reprint author), US Mil Acad, Dept Behav Sci & Leadership, Thayer Hall,Room 282B, West Point, NY 10996 USA. EM morten.ender@usma.edu NR 3 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0268-5809 J9 INT SOCIOL JI Int. Sociol. PD SEP PY 2010 VL 25 IS 5 BP 736 EP 739 DI 10.1177/0268580910373991 PG 4 WC Sociology SC Sociology GA 646RB UT WOS:000281558600031 ER PT J AU Cordes, JA Lee, J Myers, TL Hader, G Reinhardt, L Kessler, C Gray, N Guevara, MA AF Cordes, J. A. Lee, J. Myers, T. L. Hader, G. Reinhardt, L. Kessler, C. Gray, N. Guevara, M. A. TI Statistical Comparisons Between Qualification Tests for Gun-Fired Projectiles SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 25th International Symposium on Ballistics CY MAY 17-21, 2010 CL Nanjing Univ Sci & Technolog, China Ordnance Soc, Beijing, PEOPLES R CHINA SP Int Ballistics Comm, Natl Defense Ind Assoc, USA HO Nanjing Univ Sci & Technolog, China Ordnance Soc DE Excalibur; guns; accelerations; setback; set forward; balloting; launch dynamics; ballistics; shock response; reliability; failure AB The U.S. Army uses several types of tests to increase the reliability of gun-fired munitions. Systems, subsystems, and components are gun fired to assess reliability. When failures are found, root-cause investigations are completed and parts may be redesigned. For instance, the 155 mm projectile Excalibur uses several types of tests to find failures and build reliability. Components are tested in a rail gun, a new soft-catch gun, and in soft recovery vehicles. With the rail gun, test projectiles are fired from a worn gun tube into a trough of water The soft-catch gun, a hybrid system using both air and water has a standard cannon tube and a series of catch tubes to stop a projectile. The third type of test, a soft recovery vehicle, uses a modified tactical Excalibur with a parachute for a soft landing. All three types of tests have on-board recorders to capture ballistic accelerations. Accelerometer data are used in failure investigations, redesign parts, and to design new projectiles. The purpose of this paper is to compare accelerations from different types of ballistic tests. Comparisons were done to determine if the tests were in the same statistical family Comparisons are made for a United States MACS 5 charge. The maximum axial forces were the same for the soft-catch gun and the soft recovery vehicle. In the balloting directions, the rail gun and soft recovery vehicle had similar forces. The set forward forces differed in all three cases, reflecting the different catch mechanisms for the projectiles. Comparisons of g-forces were also made using shock response spectra. The shock response indicated that the damage potential is greatest for the rail gun tests, consistent with an increase rate of failures for some electronics. [DOI: 10.1115/1.4001697] C1 [Cordes, J. A.; Lee, J.; Myers, T. L.; Hader, G.; Reinhardt, L.; Kessler, C.; Gray, N.; Guevara, M. A.] USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Cordes, JA (reprint author), USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. EM jennifer.cordes@us.army.mil NR 15 TC 2 Z9 2 U1 1 U2 9 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD SEP PY 2010 VL 77 IS 5 SI SI AR 051602 DI 10.1115/1.4001697 PG 6 WC Mechanics SC Mechanics GA 649JV UT WOS:000281765800013 ER PT J AU Xu, W Li, LL Dong, HM Gumbs, G Folkes, PA AF Xu, W. Li, L. L. Dong, H. M. Gumbs, G. Folkes, P. A. TI Band hybridization and spin-splitting in InAs/AlSb/GaSb type II and broken-gap quantum wells SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ENVELOPE-FUNCTION APPROXIMATION; SEMICONDUCTOR SUPERLATTICES; ELECTRONIC-STRUCTURE; HETEROSTRUCTURES; HOLE AB We present a detailed theoretical study on the features of band hybridization and zero-field spin-splitting in InAs/AlSb/GaSb quantum wells (QWs). An eight-band k . p approach is developed to calculate the electronic subband structure in such structures. In the absence of the AlSb layer, the hybridized energy gaps can be observed at the anticrossing points between the lowest electron subband and the highest heavy-hole subband in the InAs and GaSb layers respectively. In such a case, the position and magnitude of the gaps are spin-dependent. When a thin AlSb layer is inserted between the InAs and GaSb layers, we find that the lowest electron subband in the InAs layer is only hybridized with the highest light-hole subband which is also hybridized with the highest heavy-hole subband in the GaSb layer. The hybridized energy gaps and spin-splitting in the InAs/AlSb/GaSb QWs are reduced significantly. These results can be used to understand why electrons and holes can be well separated and why relatively high mobilities for electrons and holes can be achieved in InAs/AlSb/GaSb type II and broken-gap QWs. The present study is relevant to the applications of InAs/GaSb based QW structures as new generation of high-density and high-mobility electronic devices. (C) 2010 American Institute of Physics. [doi :10.1063/1.3476059] C1 [Xu, W.; Li, L. L.; Dong, H. M.] Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China. [Xu, W.] Yunnan Univ, Dept Phys, Kunming 650091, Peoples R China. [Gumbs, G.] CUNY Hunter Coll, New York, NY 10021 USA. [Folkes, P. A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Xu, W (reprint author), Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China. EM wenxu_issp@yahoo.cn RI Dong, HaiMing/G-5143-2010 FU Chinese Academy of Sciences [2007CB925004]; National Natural Science Foundation of China [90503005]; Department of Science and Technology of Yunnan Provence FX This work was supported by the Chinese Academy of Sciences (Grant No. 2007CB925004), National Natural Science Foundation of China (Grant No. 90503005), and by the Department of Science and Technology of Yunnan Provence. NR 24 TC 11 Z9 11 U1 5 U2 18 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 2010 VL 108 IS 5 AR 053709 DI 10.1063/1.3476059 PG 9 WC Physics, Applied SC Physics GA 658GQ UT WOS:000282478900042 ER PT J AU Zhang, J Cole, MW Alpay, SP AF Zhang, J. Cole, M. W. Alpay, S. P. TI Pyroelectric properties of barium strontium titanate films: Effect of thermal stresses SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID FERROELECTRIC THIN-FILMS; DIELECTRIC-PROPERTIES; INFRARED DETECTORS; INTERNAL-STRESSES; TUNABILITY; TEMPERATURE; SUBSTRATE; SILICON; DEVICES AB A nonlinear thermodynamic model is used to investigate the influence of thermal stresses on the room temperature (RT) pyroelectric properties of (001)-textured polycrystalline barium strontium titanate (Ba(x)Sr(1-x)TiO(3), BST) films with four different compositions on three integrated circuit-friendly substrates: Si, (0001) and ((1) over bar(1) over bar 20) sapphire. It is found that the in-plane tensile thermal strain in BST increases with increasing deposition/processing temperature T(G) due to the difference of thermal expansion coefficients between the BST film and the selected substrate materials. Considering the variations in the ferroelectric phase transformation due to thermal strains, our findings show that relatively lower processing temperatures would result in better pyroelectric response. For BST 60/40 and 70/30 on all the substrates, the film is in the paraelectric state for T(G)=25-800 degrees C and the pyroelectric response is due to the interplay of the electric field and thermal strain dependence of the dielectric constant and the T(G)-dependence of the thermal strains. While the RT pyroelectric response of these films is expected to be relatively low (0.02-0.05 mu C/cm(2) K at similar to 200 kV/cm), at high applied fields the pyroelectric properties do not display a significant dependence on the temperature at which the material was treated. On the other hand, BST 80/20 and BST 90/10 films may be in the ferroelectric state at RT depending on T(G). If T(G) can be adjusted such that the ferroelectric phase transformation is near RT, a relatively high bulklike pyroelectric response (>0.5-1.0 mu C/cm(2) K) can be realized. However, the pyroelectric coefficient decreases sharply above and below these "critical" T(G), and thus a precise temperature control during processing would be required. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3475482] C1 [Zhang, J.; Alpay, S. P.] Univ Connecticut, Dept Chem Mat & Biomol Engn, Mat Sci & Engn Program, Storrs, CT 06269 USA. [Cole, M. W.] USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, J (reprint author), Univ Connecticut, Dept Chem Mat & Biomol Engn, Mat Sci & Engn Program, Storrs, CT 06269 USA. EM p.alpay@ims.uconn.edu RI Alpay, Pamir/E-2666-2013 FU U.S. Army Research Office [W911NF-05-1-0528, W911NF-08-C-0124] FX The work at UConn was supported by the U.S. Army Research Office through Grant Nos. W911NF-05-1-0528 and W911NF-08-C-0124. NR 30 TC 26 Z9 26 U1 5 U2 32 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 2010 VL 108 IS 5 AR 054103 DI 10.1063/1.3475482 PG 7 WC Physics, Applied SC Physics GA 658GQ UT WOS:000282478900075 ER PT J AU Nuss, JE Wanner, LM Tressler, LE Bavari, S AF Nuss, Jonathan E. Wanner, Laura M. Tressler, Lyal E. Bavari, Sina TI The Osmolyte Trimethylamine N-Oxide (TMAO) Increases the Proteolytic Activity of Botulinum Neurotoxin Light Chains A, B, and E: Implications for Enhancing Analytical Assay Sensitivity SO JOURNAL OF BIOMOLECULAR SCREENING LA English DT Article DE botulinum neurotoxin; osmolytes; protein folding; analytical assay; enzyme ID GLUCOCORTICOID-RECEPTOR; INFANT BOTULISM; SNAP-25; CONFORMATION; SUBSTRATE; HEADACHE; SEROTYPE; TOXIN; SERUM AB Botulism, the disease caused by botulinum neurotoxins (BoNTs), secreted by the spore-forming, anaerobic bacteria Clostridium botulinum, has been associated with food poisoning for centuries. In addition, the potency of BoNTs coupled with the current political climate has produced a threat of intentional, malicious poisoning by these toxins. The ability to detect and measure BoNTs in complex matrixes is among the highest research priorities. However, the extreme potency of these toxins necessitates that assays be capable of detecting miniscule quantities of these proteins. Thus, signal-boosting strategies must be employed. A popular approach uses the proteolytic activity of the BoNT light chain (LC) to catalyze the cleavage of synthetic substrates; reaction products are then analyzed by the analytical platform of choice. However, BoNT LCs are poor catalysts. In this study, the authors used the osmolyte trimethylamine N-oxide (TMAO) to increase the proteolytic activities of BoNT LCs. Their data suggest that concentrated solutions of TMAO induce complete folding of the LCs, resulting in increased substrate affinity and enhanced enzyme turnover. The authors observed increases in catalysis for BoNT serotypes A, B, and E, and this increased proteolytic activity translated into substantial increases in analytical assay sensitivity for these medically relevant toxins. (Journal of Biomolecular Screening 2010:928-936) C1 [Nuss, Jonathan E.; Wanner, Laura M.; Tressler, Lyal E.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM sina.bavari@amedd.army.mil FU Defense Threat Reduction Agency [3.10084_09_RD_B] FX This research was supported by a grant awarded to SB from the Defense Threat Reduction Agency (3.10084_09_RD_B). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army. NR 37 TC 6 Z9 6 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1087-0571 J9 J BIOMOL SCREEN JI J. Biomol. Screen PD SEP PY 2010 VL 15 IS 8 BP 928 EP 936 DI 10.1177/1087057110374996 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Chemistry GA 675BS UT WOS:000283799400003 PM 20720092 ER PT J AU Tokish, JM McBratney, CM Solomon, DJ LeClere, L Dewing, CB Provencher, MT AF Tokish, John M. McBratney, Colleen M. Solomon, Daniel J. LeClere, Lance Dewing, Christopher B. Provencher, Matthew T. TI Arthroscopic Repair of Circumferential Lesions of the Glenoid Labrum Surgical Technique SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article AB BACKGROUND: Symptomatic pan-labral or circumferential (360) tears of the glenohumeral labrum are an uncommon injury. The purpose of the present study was to report the results of surgical treatment of circumferential lesions of the glenoid labrum with use of validated outcome instruments. METHODS: From July 2003 to May 2006, forty-one shoulders in thirty-nine patients (thirty-four men and five women) with a mean age of 25.1 years were prospectively enrolled in a multicenter study and were managed for a circumferential (360) lesion of the glenoid labrum. All patients had a primary diagnosis of pain and recurrent shoulder instability, and all underwent arthroscopic repair of the circumferential labral tear with a mean of 7.1 suture anchors. The outcomes for thirty-nine of the forty-one shoulders were assessed after a mean duration of follow-up of 31.8 months on the basis of the rating of pain and instability on a scale of 0 to 10, a physical examination, and three outcome instruments (the Single Assessment Numeric Evaluation score, the modified American Shoulder and Elbow Surgeons score, and the Short Form-12 score). RESULTS: Significant improvement was noted in terms of the mean pain score (from 4.3 to 1.1), the mean instability score (from 7.3 to 0.2), the mean modified American Shoulder and Elbow Surgeons score (from 55.5 to 89.6), the mean Short Form-12 score (from 75.7 to 90.0), and the mean Single Assessment Numeric Evaluation score (from 36.7 to 88.5). Six shoulders required revision surgery because of recurrent instability (two), recalcitrant biceps tendinitis (two), or postoperative tightness (two). All patients returned to their preinjury activity level. CONCLUSIONS: Pan-labral or circumferential lesions are an uncommon yet extensive injury of the glenohumeral joint that may result in recurrent instability and pain. The present study demonstrates that arthroscopic capsulolabral repair with suture anchor fixation can restore the stability of the glenohumeral joint and can provide a reliable improvement in subjective and objective outcome measures. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence. ORIGINAL ABSTRACT CITATION: "Arthroscopic Repair of Circumferential Lesions of the Glenoid Labrum" (2009;91:2795-802). C1 USAF Acad, Colorado Springs, CO 80840 USA. USN, San Diego Med Ctr, San Diego, CA 92134 USA. RP Tokish, JM (reprint author), Tripler Army Med Ctr, Dept Orthoped, 1 Jarrett White Rd, Honolulu, HI 96819 USA. FU Arthrex; Pacific Medical FX The authors did not receive any outside funding or grants in support of their research for or preparation of this work. One or more of the authors, or a member of his or her immediate family, received, in any one year, payments or other benefits of less than $10,000 or a commitment or agreement to provide such benefits from commercial entities (Arthrex and Pacific Medical). NR 4 TC 8 Z9 8 U1 0 U2 1 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD SEP PY 2010 VL 92A SU 1 BP 130 EP 144 DI 10.2106/JBJS.J.00234 PN 2 PG 15 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 649PT UT WOS:000281785400002 PM 20844170 ER PT J AU Kucan, J Bryant, E Dimick, A Sundance, P Cope, N Richards, R Anderson, C AF Kucan, John Bryant, Ernest Dimick, Alan Sundance, Paula Cope, Nathan Richards, Reginald Anderson, Chris TI Systematic Care Management: A Comprehensive Approach to Catastrophic Injury Management Applied to a Catastrophic Burn Injury Population-Clinical, Utilization, Economic, and Outcome Data in Support of the Model SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article AB The new standard for successful burn care encompasses both patient survival and the burn patient's long-term quality of life. To provide optimal long-term recovery from catastrophic injuries, including catastrophic burns, an outcome-based model using a new technology called systematic care management (SCM) has been developed. SCM provides a highly organized system of management throughout the spectrum of care that provides access to outcome data, consistent oversight, broader access to expert providers, appropriate allocation of resources, and greater understanding of total costs. Data from a population of 209 workers' compensation catastrophic burn cases with a mean TBSA of 27.9% who were managed under the SCM model of care were analyzed. The data include treatment type, cost, return to work, and outcomes achieved. Mean duration of management to achieve all guaranteed outcomes was 20 months. Of the 209 injured workers, 152 (72.7%) achieved sufficient recovery to be released to return to work, of which 97 (46.8%) were both released and competitively employed. Assessment of 10 domains of functional independence indicated that 47.2% of injured workers required total assistance at initiation of SCM. However, at termination of SCM, 84% of those injured workers were fully independent in the 10 functional activities. When compared with other burn research outcome data, the results support the value of the SCM model of care. (J Burn Care Res 2010; 31: 692-700) C1 [Kucan, John; Bryant, Ernest; Dimick, Alan; Sundance, Paula; Cope, Nathan; Anderson, Chris] Paradigm Management Serv, Concord, CA 94520 USA. [Richards, Reginald] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Bryant, E (reprint author), Paradigm Management Serv, 1001 Galaxy Way,Suite 300, Concord, CA 94520 USA. NR 15 TC 5 Z9 5 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2010 VL 31 IS 5 BP 692 EP 700 DI 10.1097/BCR.0b013e3181eebed5 PG 9 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 647NE UT WOS:000281624400002 PM 20661152 ER PT J AU Kim, C McGlynn, KA McCorkle, R Zheng, TZ Erickson, RL Niebuhr, DW Ma, SG Zhang, YQ Bai, YN Dai, L Graubard, BI Kilfoy, B Barry, KH Zhang, YW AF Kim, Christopher McGlynn, Katherine A. McCorkle, Ruth Zheng, Tongzhang Erickson, Ralph L. Niebuhr, David W. Ma, Shuangge Zhang, Yaqun Bai, Yana Dai, Li Graubard, Barry I. Kilfoy, Briseis Barry, Kathryn Hughes Zhang, Yawei TI Fertility among testicular cancer survivors: a case-control study in the US SO JOURNAL OF CANCER SURVIVORSHIP-RESEARCH AND PRACTICE LA English DT Article DE Fertility; Testicular cancer; Epidemiology ID GERM-CELL TUMORS; CHEMOTHERAPY; INFERTILITY AB Introduction Testicular germ cell tumors (TGCT) disproportionately affect men between the ages of 15 and 49 years, when reproduction is typical. Although TGCT treatment directly affects gonadal tissues, it remains unclear whether there are long-term effects on fertility. Methods To examine post-TGCT treatment fertility, study participants in a previously conducted case-control study were contacted. The men were initially enrolled in the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) study between 2002 and 2005. A total of 246 TGCT cases and 236 controls participated in the current study and completed a self-administered questionnaire in 2008-2009. Results TGCT cases were significantly more likely than controls to experience fertility distress (OR 5.23; 95% CI 1.99-13.76) and difficulty in fathering children (OR 6.41; 2.72-15.13). Cases were also more likely to be tested for infertility (OR 3.65; 95% CI 1.55-8.59). Cases, however, did not differ from controls in actually fathering children (OR 1.37; 95% CI 0.88-2.15). These findings were predominantly observed among nonseminoma cases and cases treated with surgery only or surgery-plus-chemotherapy. Discussion While expressing greater fertility distress, higher likelihood of fertility testing, and difficulty fathering children, these data suggest that TGCT survivors are no less likely to father children than are other men. It is possible that treatment for TGCT does not permanently affect C1 [Kim, Christopher; Ma, Shuangge; Zhang, Yaqun; Bai, Yana; Dai, Li; Barry, Kathryn Hughes; Zhang, Yawei] Yale Univ, Yale Sch Publ Hlth, New Haven, CT 06520 USA. [McGlynn, Katherine A.; Zheng, Tongzhang; Graubard, Barry I.; Kilfoy, Briseis; Barry, Kathryn Hughes] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Rockville, MD USA. [McCorkle, Ruth] Yale Univ, Yale Sch Nursing, New Haven, CT 06520 USA. [Erickson, Ralph L.; Niebuhr, David W.] Walter Reed Army Inst Res, Forest Glen, MD USA. [Zhang, Yawei] Gansu Prov Design & Res Inst Environm Sci, Lanzhou, Gansu, Peoples R China. [Bai, Yana] Lanzhou Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Lanzhou 730000, Peoples R China. [Dai, Li] Sichuan Univ, W China Univ Hosp 2, Natl Ctr Birth Defect Monitoring, Chengdu 610064, Peoples R China. RP Zhang, YW (reprint author), Yale Univ, Yale Sch Publ Hlth, 60 Coll St,LEPH 440, New Haven, CT 06520 USA. EM yawei.zhang@yale.edu RI Aschebrook-Kilfoy, Briseis/A-2537-2012 FU National Cancer Institute (NCI) [CA130110]; National Institute of Health (NIH) [1D43TW008323-01, 1D43TW007864-01]; National Center for Research Resources (NCRR), NIH [UL1 RR024139] FX This study is supported by grant CA130110 from the National Cancer Institute (NCI) and by Fogarty training grants 1D43TW008323-01 and 1D43TW007864-01 from the National Institute of Health (NIH). This publication was made possible by CTSA Grant number UL1 RR024139 from the National Center for Research Resources (NCRR), a component of the NIH and NHL roadmap for medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR. The authors are greatly indebted to the Study participants, without whom, there would have been no study. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 23 TC 6 Z9 7 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1932-2259 J9 J CANCER SURVIV JI J. Cancer Surviv.-Res. Pract. PD SEP PY 2010 VL 4 IS 3 BP 266 EP 273 DI 10.1007/s11764-010-0134-x PG 8 WC Oncology; Social Sciences, Biomedical SC Oncology; Biomedical Social Sciences GA 788TZ UT WOS:000292468600009 PM 20571931 ER PT J AU Villines, TC AF Villines, Todd C. TI Keeping score of coronary artery disease using cardiac CT angiography: Can reasonable experts agree? SO JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Villines, TC (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM todd.villines@amedd.army.mil OI Villines, Todd/0000-0003-2674-3702 NR 13 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-5925 J9 J CARDIOVASC COMPUT JI J. Cardiovasc. Comput. Tomogr. PD SEP-OCT PY 2010 VL 4 IS 5 BP 319 EP 321 DI 10.1016/j.jcct.2010.07.001 PG 3 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA V26BS UT WOS:000208521700006 PM 20719589 ER PT J AU Kobayashi, N Farhadzadeh, A Melby, J Johnson, B Gravens, M AF Kobayashi, Nobuhisa Farhadzadeh, Ali Melby, Jeffrey Johnson, Bradley Gravens, Mark TI Wave Overtopping of Levees and Overwash of Dunes SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Wave overtopping; overflow; levees; dune; overwash; erosion ID STORM AB Earthen levees are designed for little wave overtopping during a design storm, but excessive overtopping and overflow can occur due to the combined effects of an extreme storm, sea level rise, and land subsidence. The transition from little wave overtopping to excessive wave overtopping and overflow on an impermeable smooth levee is examined in wave-flume experiments consisting of 107 tests. Existing empirical formulas are shown to be applicable to the cases of excessive wave overtopping and overflow in these tests. A numerical model based on time-averaged continuity, momentum, and wave action equations is connected to a new probabilistic model for the wet-and-dry zone, in order to predict the cross-shore variations of the mean and standard deviation of the free surface elevation and depth-averaged fluid velocity from outside the surf zone to the inner slope of the levee. The new model is calibrated to predict the measured overtopping and overflow rates within a factor of about two. The agreement is also shown to be similar for the water depths and velocities measured in the wet-and-dry zone on six different structures in 100 Dutch tests. The developed hydrodynamic model is coupled with new formulas for suspended-sand and bedload transport rates to predict dune erosion and overwash. The coupled model is compared with two small-scale tests on dune erosion with minor overwash, three large-scale tests on dune erosion, and field data on dune erosion and overwash due to severe storms lasting several days. The overwashed-dune profiles are predicted reasonably well, but the coupled model will need to be evaluated using measurements of wave overtopping and overwash rates. C1 [Kobayashi, Nobuhisa; Farhadzadeh, Ali] Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. [Melby, Jeffrey; Johnson, Bradley; Gravens, Mark] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Kobayashi, N (reprint author), Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. EM nk@udel.edu FU U.S. Army Corps of Engineers Coastal and Hydraulics Laboratory [W912BU-07-C0013, W912HZ-08-P-0342] FX This study was supported by the U.S. Army Corps of Engineers Coastal and Hydraulics Laboratory under contracts W912BU-07-C0013 and W912HZ-08-P-0342. The authors would like to thank C. Ricottilli for her assistance in the experiments as well as H. Schuttrumpf and M.R.A. Van Gent for providing their reports. NR 25 TC 16 Z9 16 U1 0 U2 5 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SEP PY 2010 VL 26 IS 5 BP 888 EP 900 DI 10.2112/JCOASTRES-D-09-00034.1 PG 13 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 656SZ UT WOS:000282358200011 ER PT J AU Hammoud, DA Munter, FM Brat, DJ Pomper, MG AF Hammoud, Dima A. Munter, Fletcher M. Brat, Daniel J. Pomper, Martin G. TI Magnetic Resonance Imaging Features of Pituicytomas: Analysis of 10 Cases SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE pituicytoma; neurohypophyseal tumor; MRI ID POSTERIOR PITUITARY; BENIGN-TUMOR; NEUROHYPOPHYSIS; ASTROCYTOMA AB Objective: To describe the magnetic resonance imaging features of pituicytomas and identify any specific features that could differentiate this tumor from other sellar/suprasellar masses. Methods: Magnetic resonance images, clinical histories, and pathological findings of 10 patients with pituicytoma were retrospectively reviewed. Reports of clinical history, pathology, and magnetic resonance imaging findings were reviewed for 28 additional histologically proven pituicytoma cases, previously reported in the literature. Results: Pituicytomas were mostly round or oval, sharply defined, and located in the sellar and/or suprasellar region. Tumors were generally isointense to gray matter on T1-weighted images and isointense to slightly hyperintense on T2-weighted images, and they enhanced intensely. Conclusions: Magnetic resonance imaging features of pituicytomas overlap with those of other, more common lesions that occur in the region. With the exception of a purely suprasellar-enhancing mass or a clearly defined neurohypophyseal mass separate from the anterior pituitary, the similarity to common tumors such as macroadenomas and meningiomas probably precludes effective prospective diagnosis of pituicytomas. C1 [Hammoud, Dima A.] NIH, Ctr Clin, Bethesda, MD 20892 USA. [Munter, Fletcher M.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Brat, Daniel J.] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA. [Pomper, Martin G.] Johns Hopkins Med Inst, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21205 USA. RP Hammoud, DA (reprint author), NIH, Ctr Clin, 10 Ctr Dr,Room 1C336, Bethesda, MD 20892 USA. EM hammoudd@cc.nih.gov RI Hammoud, Dima/C-2286-2015 NR 20 TC 20 Z9 23 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD SEP-OCT PY 2010 VL 34 IS 5 BP 757 EP 761 DI 10.1097/RCT.0b013e3181e289c0 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 653OD UT WOS:000282100400019 PM 20861781 ER PT J AU Soga, S Ersoy, H Mitsouras, D Schultz, K Whitmore, AG Powers, SL Steigner, ML Signorelli, J Prior, RF Rybicki, FJ Pomahac, B AF Soga, Shigeyoshi Ersoy, Hale Mitsouras, Dimitrios Schultz, Kurt Whitmore, Amanda G. Powers, Sara L. Steigner, Michael L. Signorelli, Jason Prior, Richard F. Rybicki, Frank J. Pomahac, Bohdan TI Surgical Planning for Composite Tissue Allotransplantation of the Face Using 320-Detector Row Computed Tomography SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE 320-detector row CT; face transplant; CT angiography; perfusion CT; surgical planning ID FACIAL ARTERY; MIDFACIAL ALLOTRANSPLANTATION; VASCULAR CONSIDERATIONS; TRANSPLANTATION; ANGIOGRAPHY; PERFUSION; PATIENT AB We report initial surgical planning computed tomographic protocols for composite tissue allotransplantation of the face. This complex procedure replaces missing facial structures with anatomically identical tissues, restoring form and function. Achieved results are superior to those accomplished with conventional techniques. As a growing number of patients/recipients have undergone multiple reconstructions, vascular imaging plays an increasingly critical role in surgical planning and successful execution of the operation. C1 [Soga, Shigeyoshi; Ersoy, Hale; Mitsouras, Dimitrios; Whitmore, Amanda G.; Powers, Sara L.; Steigner, Michael L.; Signorelli, Jason; Prior, Richard F.; Rybicki, Frank J.] Brigham & Womens Hosp, Dept Radiol, Appl Imaging Sci Lab, Boston, MA 02115 USA. [Schultz, Kurt] USA, Toshiba Med Res Inst, Vernon Hills, IL USA. [Pomahac, Bohdan] Brigham & Womens Hosp, Dept Plast & Reconstruct Surg, Boston, MA 02115 USA. RP Rybicki, FJ (reprint author), Brigham & Womens Hosp, Dept Radiol, Appl Imaging Sci Lab, 75 Francis St, Boston, MA 02115 USA. EM frybicki@partners.org FU US Department of Defense [W911QY-09-C-021] FX The work was supported by US Department of Defense contract W911QY-09-C-021. NR 20 TC 14 Z9 14 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD SEP-OCT PY 2010 VL 34 IS 5 BP 766 EP 769 DI 10.1097/RCT.0b013e3181e9c133 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 653OD UT WOS:000282100400021 PM 20861783 ER PT J AU Moore, D Schmeeckle, A Coleman, JC Moore, RG AF Moore, D. Schmeeckle, A. Coleman, J. C. Moore, R. G. TI OVERTON BROOKS VAMC PRELIMINARY FINDING IN PATIENTS EXPOSED TO AGENT ORANGE WITH RENAL CELL CANCER SO JOURNAL OF ENDOUROLOGY LA English DT Meeting Abstract C1 [Moore, D.; Schmeeckle, A.; Moore, R. G.] Overton Brook VAMC, Shreveport, LA USA. [Coleman, J. C.] US Mil Acad, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0892-7790 J9 J ENDOUROL JI J. Endourol. PD SEP PY 2010 VL 24 SU 1 BP A305 EP A305 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 675UR UT WOS:000283864901303 ER PT J AU Rees, DI Sabia, JJ AF Rees, Daniel I. Sabia, Joseph J. TI Body weight and smoking initiation: Evidence from Add Health SO JOURNAL OF HEALTH ECONOMICS LA English DT Article DE Smoking; Obesity; Body weight; Adolescent ID ADOLESCENT SMOKING; OBESITY; ADOPTION AB In volume 23, issue 2 of this journal, Cawley, Markowitz and Tauras used data from the National Longitudinal Survey of Youth 1997 Cohort to estimate the relationship between body weight and smoking initiation. Using maternal obesity status as an instrument, they found strong evidence that overweight females between the ages of 12 and 21 were more likely to initiate smoking. Drawing on data from the National Longitudinal Study of Adolescent Health, we reexamine the relationship between body weight and smoking initiation. Our results are generally consistent with those of Cawley, Markowitz and Tauras. Published by Elsevier B.V. C1 [Sabia, Joseph J.] US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA. [Rees, Daniel I.] Univ Colorado Denver, Dept Econ, Denver, CO 80217 USA. RP Sabia, JJ (reprint author), US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA. EM Daniel.Rees@ucdenver.edu; Joseph.Sabia@usma.edu FU National Institute of Child Health and Human Development [P01-HD31921] FX This research uses data from Add Health, a program project designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris, and funded by a grant P01-HD31921 from the National Institute of Child Health and Human Development, with cooperative funding from 17 other agencies. Special acknowledgment is due Ronald R. Rindfuss and Barbara Entwisle for assistance in the original design. Persons interested in obtaining data files from Add Health should contact Add Health, Carolina Population Center, 123 W. Franklin Street, Chapel Hill, NC 27516-2524 NR 8 TC 10 Z9 10 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6296 J9 J HEALTH ECON JI J. Health Econ. PD SEP PY 2010 VL 29 IS 5 BP 774 EP 777 DI 10.1016/j.jhealeco.2010.07.002 PG 4 WC Economics; Health Care Sciences & Services; Health Policy & Services SC Business & Economics; Health Care Sciences & Services GA 655LE UT WOS:000282250700014 PM 20708283 ER PT J AU Wang, XH Sathunuru, R Melendez, V Kozar, MP Lin, AJ AF Wang, Xihong Sathunuru, Ramadas Melendez, Victor Kozar, Michael P. Lin, Ai J. TI Facile Synthesis of 2,4-Diamino-6-alkyl- or 6-Aryl-Pyrimidine Derivatives SO JOURNAL OF HETEROCYCLIC CHEMISTRY LA English DT Article ID IMIDAZOLIDINEDIONE DERIVATIVES; PYRIMIDINE-DERIVATIVES; INHIBITORS; ANTITUMOR; SAR AB Facile methods were developed to prepare a series of 6-phenyl and 6-alkyl-2,4-diaminopyrimidine derivatives. The pyrimidine ring of the final products was constructed by treatment of a 1,3-dicarbonyl derivative with an amidine or guanidine. The 6-phenyl-pyrimidine derivatives were also prepared by Suzuki coupling reaction, using 2-methylthio-4,6-dichloropyrimidine as the starting material. C1 [Wang, Xihong; Sathunuru, Ramadas; Melendez, Victor; Kozar, Michael P.; Lin, Ai J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM ai.lin@us.army.mil RI Kozar, Michael/A-9155-2011 FU Military Infectious Diseases Research Program [A40096_06_WR_CSPP]; US Army Medical Research and Materiel Command, Department of Defense, USA; Peer Reviewed Medical Research Program (PRMRP) [PR054609]; Malaria and Medicine Venture (MMV), Geneva, Switzerland [MMV04/0013] FX Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publications. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. This research is supported by funding from Military Infectious Diseases Research Program (A40096_06_WR_CSPP), US Army Medical Research and Materiel Command, Department of Defense, USA; Peer Reviewed Medical Research Program (PRMRP) (grant #PR054609), and Malaria and Medicine Venture (MMV), Geneva, Switzerland, (grant #MMV04/0013). NR 15 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-152X J9 J HETEROCYCLIC CHEM JI J. Heterocycl. Chem. PD SEP PY 2010 VL 47 IS 5 BP 1056 EP 1061 DI 10.1002/jhet.419 PG 6 WC Chemistry, Organic SC Chemistry GA 658KP UT WOS:000282489200008 ER PT J AU Haacke, EM Duhaime, AC Gean, AD Riedy, G Wintermark, M Mukherjee, P Brody, DL DeGraba, T Duncan, TD Elovic, E Hurley, R Latour, L Smirniotopoulos, JG Smith, DH AF Haacke, E. Mark Duhaime, Ann Christine Gean, Alisa D. Riedy, Gerard Wintermark, Max Mukherjee, Pratik Brody, David L. DeGraba, Thomas Duncan, Timothy D. Elovic, Elie Hurley, Robin Latour, Lawrence Smirniotopoulos, James G. Smith, Douglas H. TI Common Data Elements in Radiologic Imaging of Traumatic Brain Injury SO JOURNAL OF MAGNETIC RESONANCE IMAGING LA English DT Review DE traumatic brain injury; common data elements; characterization of TBI; multi-modality imaging of TBI; TBI imaging database ID DIFFUSE AXONAL INJURY; MAGNETIC-RESONANCE-SPECTROSCOPY; CEREBRAL-BLOOD-FLOW; ROUTINE CLINICAL-PRACTICE; PROTON MR SPECTROSCOPY; SEVERE HEAD TRAUMA; WHITE-MATTER INJURY; PERFUSION-CT; FUNCTIONAL MRI; TECHNETIUM-99M-HMPAO SPECT AB Traumatic brain injury (TBI) has a poorly understood pathology. Patients suffer from a variety of physical and cognitive effects that worsen as the type of trauma worsens. Some noninvasive insights into the pathophysiology of TBI are possible using magnetic resonance imaging (MRI), computed tomography (CT), and many other forms of imaging as well A recent workshop was convened to evaluate the common data elements (CDEs) that cut across the imaging field and given the charge to review the contributions of the various imaging modalities to TBI and to prepare an overview of the various clinical manifestations of TBI and their interpretation. Technical details regarding state-of-the-art protocols for both MRI and CT are also presented with the hope of guiding current and future research efforts as to what is possible in the field. Stress was also placed on the potential to create a database of CDEs as a means to best record information from a given patient from the reading of the images. C1 [Haacke, E. Mark] Wayne State Univ, MR Res Facil, Dept Radiol & Biomed Engn, Detroit, MI 48201 USA. [Duhaime, Ann Christine] Dartmouth Hitchcock Med Ctr, Dept Pediat Neurosurg, Lebanon, NH 03766 USA. [Gean, Alisa D.] San Francisco Gen Hosp, Dept Radiol, Brain & Spinal Cord Injury Ctr, San Francisco, CA 94110 USA. [Riedy, Gerard] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Wintermark, Max; Mukherjee, Pratik] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA. [Mukherjee, Pratik] Univ Calif San Francisco, Dept Bioengn, San Francisco, CA 94143 USA. [Brody, David L.] Washington Univ, Dept Neurol, St Louis, MO USA. [DeGraba, Thomas] Natl Naval Med Ctr, Bethesda, MD USA. [Duncan, Timothy D.] Naval Med Ctr San Diego, Dept Radiol, San Diego, CA USA. [Elovic, Elie] Univ Utah, Hlth Sci Ctr, Div Phys Med & Rehabil, Salt Lake City, UT USA. [Hurley, Robin] Hefner VA Med Ctr, Salisbury, NC USA. [Latour, Lawrence] NINDS, Stroke Diagnost & Therapeut Sect, Stroke Branch, Bethesda, MD 20892 USA. [Smirniotopoulos, James G.] Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD USA. [Smith, Douglas H.] Univ Penn, Dept Neurosurg, Ctr Brain Injury & Repair, Philadelphia, PA 19104 USA. RP Haacke, EM (reprint author), Wayne State Univ, MR Res Facil, Dept Radiol & Biomed Engn, 3990 John R Rd, Detroit, MI 48201 USA. EM nmrimaging@aol.com RI smith, douglas/A-1321-2007; Smirniotopoulos, James/D-3726-2011; Mukherjee, Pratik/A-5446-2008; OI Mukherjee, Pratik/0000-0001-7473-7409; Wintermark, Max/0000-0002-6726-3951 NR 128 TC 37 Z9 41 U1 2 U2 7 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1053-1807 J9 J MAGN RESON IMAGING JI J. Magn. Reson. Imaging PD SEP PY 2010 VL 32 IS 3 BP 516 EP 543 DI 10.1002/jmri.22259 PG 28 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 646IK UT WOS:000281532700002 PM 20815050 ER PT J AU Zhu, YTT Mathaudhu, SN Goken, M Langdon, TG Lowe, TC Semiatin, SL Tsuji, N Zhao, YH AF Zhu, Yuntian T. Mathaudhu, Suveen N. Goken, Mathias Langdon, Terence G. Lowe, Terry C. Semiatin, S. Lee Tsuji, Nobuhiro Zhao, Yong Hao TI Preface to the Special Issue on Ultrafine Grained Materials SO JOURNAL OF MATERIALS SCIENCE LA English DT Editorial Material C1 [Zhu, Yuntian T.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Mathaudhu, Suveen N.] USA, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. [Goken, Mathias] Univ Erlangen Nurnberg, Inst 1, Dept Mat Sci & Engn, D-91058 Erlangen, Germany. [Langdon, Terence G.] Univ So Calif, Dept Aerosp & Mech Engn, Los Angeles, CA 90089 USA. [Langdon, Terence G.] Univ So Calif, Dept Mat Sci, Los Angeles, CA 90089 USA. [Lowe, Terry C.] Manhattan Sci Inc, New York, NY 10174 USA. [Semiatin, S. Lee] USAF, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA. [Tsuji, Nobuhiro] Kyoto Univ, Dept Mat Sci & Engn, Kyoto 6068501, Japan. [Zhao, Yong Hao] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. RP Zhu, YTT (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM ytzhu@ncsu.edu; suveen.mathaudhu@us.army.mil; goeken@ww.uni-erlangen.de; langdon@usc.edu; terry@mhtx.com; Lee.Semiatin@wpafb.af.mil; nobuhiro.tsuji@ky5.ecs.kyoto-u.ac.jp; yhzhao@ucdavis.edu RI Tsuji, Nobuhiro/F-7951-2010; Zhao, Yonghao/A-8521-2009; Mathaudhu, Suveen/B-4192-2009; Goken, Mathias/F-7940-2015 OI Tsuji, Nobuhiro/0000-0002-2132-1327; Goken, Mathias/0000-0002-3226-0304 NR 0 TC 3 Z9 3 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD SEP PY 2010 VL 45 IS 17 SI SI BP 4543 EP 4544 DI 10.1007/s10853-010-4709-8 PG 2 WC Materials Science, Multidisciplinary SC Materials Science GA 622RZ UT WOS:000279684400001 ER PT J AU Hofmeister, C Yao, B Sohn, YH Delahanty, T van den Bergh, M Cho, K AF Hofmeister, C. Yao, B. Sohn, Y. H. Delahanty, T. van den Bergh, M. Cho, K. TI Composition and structure of nitrogen-containing dispersoids in trimodal aluminum metal-matrix composites SO JOURNAL OF MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT 6th International Symposium on Ultrafine Grained Materials CY FEB 14-18, 2010 CL Seattle, WA SP Minerals, Metals & Mat Soc ID NANOSTRUCTURED MATERIALS; DUCTILITY AB Trimodal aluminum (Al) metal-matrix-composites (MMCs), consisting of B(4)C particulates, a nanocrystalline Al (NC-Al) phase, and a coarse-grain Al phase (CG-Al), has been fabricated. These MMCs exhibits extremely high compressive strength and tailorable ductility. Excellent thermal stability of NC-Al grains and high strength has been attributed partially to the nitrogen present within the trimodal Al MMCs, which is introduced during the cryomilling process in liquid nitrogen. This paper describes an investigation into the concentration and constituents of nitrogen within the trimodal Al MMCs. The structure of nitrogen-containing dispersoids was examined by analytical transmission electron microscopy (TEM), and secondary ion mass spectrometry (SIMS) was employed to determine the total concentration of nitrogen. The nitrogen concentration increased linearly with an increase in cryomilling time up to 24 h. Both crystalline and amorphous aluminum nitrides with very fine size, down to 5 nm, as dispersoids, have been observed by analytical TEM. Correlations between the cryomilling time, nitrogen concentration, NC-Al grain size, and composite hardness are presented and discussed. The presence of nitrogen as nitride-dispersoids can contribute to the outstanding mechanical properties of trimodal Al MMCs by inhibiting NC-Al grain growth during the high temperature consolidation and deformation process, and by dispersion-strengthening. C1 [Hofmeister, C.; Yao, B.; Sohn, Y. H.] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. [Hofmeister, C.; Yao, B.; Sohn, Y. H.] Univ Cent Florida, Dept Mech Mat & Aerosp Engn, Orlando, FL 32816 USA. [Delahanty, T.] Pittsburgh Mat Technol Inc, Jefferson Hills, PA 15025 USA. [van den Bergh, M.] DWA Aluminum Composites, Chatsworth, CA 91311 USA. [Cho, K.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sohn, YH (reprint author), Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. EM ysohn@mail.ucf.edu RI Sohn, Yongho/A-8517-2010; Yao, Bo/C-9927-2011 OI Sohn, Yongho/0000-0003-3723-4743; NR 19 TC 9 Z9 9 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD SEP PY 2010 VL 45 IS 17 SI SI BP 4871 EP 4876 DI 10.1007/s10853-010-4571-8 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA 622RZ UT WOS:000279684400043 ER PT J AU Turell, MJ Wilson, WC Bennett, KE AF Turell, Michael J. Wilson, William C. Bennett, Kristine E. TI Potential for North American Mosquitoes (Diptera: Culicidae) to Transmit Rift Valley Fever Virus SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Rift Valley fever; vector; transmission; North America ID SAUDI-ARABIA; CULEX-TARSALIS; PHLEBOTOMUS-DUBOSCQI; SAND FLY; VECTOR; EPIDEMIC; EGYPT; DISSEMINATION; REPLICATION; PSYCHODIDAE AB To determine which arthropods should be targeted for control should Rift Valley fever virus (RVFV) be detected in North America, we evaluated Culex erraticus (Dyar and Knab), Culex erythrothorax Dyar, Culex nigripalpus Theobald, Culex pipiens L., Culex quinquefasciatus Say, Culex torsalis Coquillett, Aedes dorsalis (Wiedemann), Aedes vexans (Meigen), Anopheles quadrimaculatus Say, and Culicoides sonorensis Wirth and Jones from the western, midwestern, and southern United States for their ability to transmit RVFV. Female mosquitoes were allowed to feed on adult hamsters inoculated with RVFV, after which engorged mosquitoes were incubated for 7-21 d at 26 degrees C, then allowed to refeed on susceptible hamsters, and tested to determine infection, dissemination, and transmission rates. Other specimens were inoculated intrathoracically, held for 7 d, and then allowed to feed on a susceptible hamster to check for a salivary gland barrier. When exposed to hamsters with viremias >= 18(8.8) plaque-forming units/ml blood, Cx. tarsalis transmitted RVFV efficiently (infection rate = 93%, dissemination rate = 56%, and estimated transmission rate = 52%). In contrast, when exposed to the same virus dose, none of the other species tested transmitted RVFV efficiently. Estimated transmission rates for Cx. erythrothorax, Cx. pipiens, Cx. erraticus, and Ae. dorsalis were 10, 8, 4, and 2%, respectively, and for the remaining species were <= 1%. With the exception of Cx. tarsal is and Cx. pipiens, all species tested had moderate to major salivary gland barriers. None of the C. sonorensis became infected and none of the An. quadrimaculatus tested transmitted RVFV by bite, even after intrathoracic inoculation, indicating that these species would not be competent vectors of RVFV. Although Ae. vexans from Florida and Louisiana were relatively efficient vectors of RVFV, specimens of this species captured in Colorado or California were virtually incompetent, illustrating the need to evaluate local population for their ability to transmit a pathogen. In addition to laboratory vector competence, factors such as seasonal density, host feeding preference, longevity, and foraging behavior should be considered when determining the potential role that these species could play in RVFV transmission. C1 [Turell, Michael J.] US Army Med Res Inst Infect Dis, Dept Vector Assessment, Div Virol, Ft Detrick, MD 21702 USA. [Wilson, William C.; Bennett, Kristine E.] ARS, Arthropod Borne Anim Dis Res Unit, USDA, Manhattan, KS 66502 USA. RP Turell, MJ (reprint author), US Army Med Res Inst Infect Dis, Dept Vector Assessment, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM michael.turell@amedd.army.mil FU United States Department of Agriculture-Agricultural Research Service Cooperative Research Information Systems (CRIS) [5410-32000-015-00D, 5410-32000-018-00D]; Department of Homeland [HSHQDC-07-X-00982] FX We thank W. Reeves and S. Funderburk, Arthropod-Borne Animal Disease Research Laboratory (ABADRL); L. Terracina, Department of Mosquito and Rodent Control, Calcasieu Parish Police jury (Lake Charles, LA); T. Sandu, North West Mosquito and Vector Control District (Corona, CA); P. Binding, Santa Cruz County Mosquito and Vector Control District (Santa Cruz, CA); S. Schutz, Contra Costa Mosquito and Vector Control District (Concord, CA); and J. Scott, Lake County Vector Control District (Lakeport, CA) for providing mosquitoes. We thank D. Dohm, USAMRIID, for his assistance in testing the mosquitoes; J. Williams for caring for the hamsters; and K. Kenyon for her editorial suggestions. This work was supported in part by United States Department of Agriculture-Agricultural Research Service Cooperative Research Information Systems (CRIS) Projects 5410-32000-015-00D and 5410-32000-018-00D, and a Department of Homeland Security Interagency Agreement HSHQDC-07-X-00982. NR 35 TC 52 Z9 52 U1 4 U2 14 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 2010 VL 47 IS 5 BP 884 EP 889 DI 10.1603/ME10007 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 649CK UT WOS:000281744600023 PM 20939385 ER PT J AU Florin, DA Lawyer, P Rowton, E Schultz, G Wilkerson, R Davies, SJ Lipnick, R Keep, L AF Florin, David A. Lawyer, Phillip Rowton, Edgar Schultz, George Wilkerson, Richard Davies, Stephen J. Lipnick, Robert Keep, Lisa TI Morphological Anomalies in Two Lutzomyia (Psathyromyia) shannoni (Diptera: Psychodidae: Phlebotominae) Specimens Collected From Fort Rucker, Alabama, and Fort Campbell, Kentucky SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Lutzomya shannoni; gonostylus; morphologic anomalies; molecular markers ID INTROGRESSION; INTERMEDIA; LEISHMANIA; VECTORS AB This report describes two male specimens of the sand fly species Lutzomyia shannoni (Dyar) (Diptera: Psychodidae: Phlebotominae) collected at Fort Rucker, AL, and Fort Campbell, KY, in dry ice-baited light traps during September 2005. The specimens were observed to have anomalies to the number of spines on the gonostyli. The taxonomic keys of Young and Perkins (Mosq. News 44: 263-285; 1984) use the number of spines on the gonostylus in the first couplet to differentiate two major groupings of North American sand flies. The two anomalous specimens were identified as L. shannoni based on the following criteria: 1) both specimens possess antennal ascoids with long, distinct proximal spurs (a near diagnostic character of L. shannoni in North America), 2) the sequences of the partial cytochrome c oxidase subunit 1 gene from both specimens indicated L. shannoni, and 3) the sequences of the internal transcribed spacer 2 molecular marker from both specimens indicated L. shannoni. The anomalous features are fundamentally different from each other as the Fort Rucker specimen possesses a fifth spine (basally located) on just one gonostylus, whereas the Fort Campbell specimen possesses five spines (extra spines subterminally located) on both gonostyli. Because the gonostyli are part of the external male genitalia, anomalies in the number of spines on the gonostyli may have serious biological consequences, such as reduced reproductive success, for the possessors. These anomalies are of taxonomic interest as the specimens could easily have been misidentified using available morphological keys. C1 [Florin, David A.; Schultz, George; Davies, Stephen J.; Keep, Lisa] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Lawyer, Phillip] Natl Inst Allergy & Infect Dis, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. [Rowton, Edgar; Wilkerson, Richard] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. [Lipnick, Robert] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. RP Florin, DA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM david.florin@usuhs.mil RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 FU Uniformed Services University of the Health Sciences [R087WB] FX This research was funded by Uniformed Services University of the Health Sciences intramural grant R087WB: Risk for domestic transmission of leishmaniasis acquired by U.S. service members in Iraq/Afghanistan. NR 10 TC 4 Z9 4 U1 0 U2 1 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 2010 VL 47 IS 5 BP 952 EP 956 DI 10.1603/ME10088 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 649CK UT WOS:000281744600032 PM 20939394 ER PT J AU Elster, EA Hawksworth, JS Cheng, O Leeser, DB Ring, M Tadaki, DK Kleiner, DE Eberhardt, JS Brown, TS Mannon, RB AF Elster, Eric A. Hawksworth, Jason S. Cheng, Orlena Leeser, David B. Ring, Michael Tadaki, Douglas K. Kleiner, David E. Eberhardt, John S., III Brown, Trevor S. Mannon, Roslyn B. TI Probabilistic (Bayesian) Modeling of Gene Expression in Transplant Glomerulopathy SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Article ID CHRONIC ALLOGRAFT NEPHROPATHY; GROWTH-FACTOR-BETA; RENAL-TRANSPLANTATION; FUTURE-DIRECTIONS; ACUTE REJECTION; T-CELLS; RECIPIENTS; BIOPSIES; INJURY; C4D AB Transplant glomerulopathy (TG) is associated with rapid decline in glomerular filtration rate and poor outcome. We used low-density arrays with a novel probabilistic analysis to characterize relationships between gene transcripts and the development of TG in allograft recipients. Retrospective review identified TG in 10.8% of 963 core biopsies from 166 patients; patients with stable function were studied for comparison. The biopsies were analyzed for expression of 87 genes related to immune function and fibrosis by using real-time PCR, and a Bayesian model was generated and validated to predict histopathology based on gene expression. A total of 57 individual genes were increased in TG compared with stable function biopsies (P < 0.05). The Bayesian analysis identified critical relationships between ICAM-1, IL-10, CCL3, CD86, VCAM-1, MMP-9, MMP-7, and LAMC2 and allograft pathology. Moreover, Bayesian models predicted TG when derived from either immune function (area under the curve [95% confidence interval] of 0.875 [0.675 to 0.999], P = 0.004) or fibrosis (area under the curve [95% confidence interval] of 0.859 [0.754 to 0.963], P < 0.001) gene networks. Critical pathways in the Bayesian models were also analyzed by using the Fisher exact test and had P values <0.005. This study demonstrates that evaluating quantitative gene expression profiles with Bayesian modeling can identify significant transcriptional associations that have the potential to support the diagnostic capability of allograft histology. This integrated approach has broad implications in the field of transplant diagnostics. (J Mol Diagn 2010, 12:653-663; DOI: 10.2353/jmoldx.2010.090101) C1 [Elster, Eric A.; Hawksworth, Jason S.; Tadaki, Douglas K.; Brown, Trevor S.] USN, Med Res Ctr, Regenerat Med Dept, Silver Spring, MD 20910 USA. [Elster, Eric A.; Hawksworth, Jason S.] Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. [Elster, Eric A.; Cheng, Orlena; Ring, Michael; Mannon, Roslyn B.] NIDDK, NIH, Washington, DC USA. [Elster, Eric A.] Natl Naval Med Ctr, Dept Surg, Silver Spring, MD USA. [Leeser, David B.] Weill Cornell Med Ctr, Dept Surg, New York, NY USA. [Kleiner, David E.] NCI, Pathol Lab, Bethesda, MD 20892 USA. [Eberhardt, John S., III] Decis Q Corp, Washington, DC USA. RP Elster, EA (reprint author), USN, Med Res Ctr, Regenerat Med Dept, Silver Spring, MD 20910 USA. EM eric.elster1@med.navy.mil RI Brown, Trevor/K-4703-2012; Brown, Trevor/F-7392-2015; OI Brown, Trevor/0000-0001-7042-785X; Brown, Trevor/0000-0001-7042-785X; Kleiner, David/0000-0003-3442-4453 FU US Navy Bureau of Medicine and Surgery; National Institute of Diabetes Digestive and Kidney Diseases [Z01-DK062008] FX Supported in part by the US Navy Bureau of Medicine and Surgery and by the intramural research program of the National Institute of Diabetes Digestive and Kidney Diseases Z01-DK062008 (R.B.M.). NR 47 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA SN 1525-1578 J9 J MOL DIAGN JI J. Mol. Diagn. PD SEP PY 2010 VL 12 IS 5 BP 653 EP 663 DI 10.2353/jmoldx.2010.090101 PG 11 WC Pathology SC Pathology GA 648JW UT WOS:000281690800014 PM 20688906 ER PT J AU Griep, M Winder, E Lueking, D Friedrich, C Mallick, G Karna, S AF Griep, Mark Winder, Eric Lueking, Donald Friedrich, Craig Mallick, Govind Karna, Shashi TI Optical Protein Modulation via Quantum Dot Coupling and Use of a Hybrid Sensor Protein SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article; Proceedings Paper CT 2nd International Conference on Advanced Nano Materials CT 1st International Conference from Nanoparticles and Nanomaterials to Nanodevices and Nanosystems (1st IC4N) CY 2008 CY JUN 16-18, 2008 CL Univ Aveiro, Aveiro, PORTUGAL CL Halkidiki, GREECE HO Univ Aveiro DE Bacteriorhodopsin; Quantum Dots; Nanotechnology; Biosensor; Maltose Binding Protein; FRET; I-SAM ID ORIENTED BACTERIORHODOPSIN/POLYCATION MULTILAYERS; MALTOSE-BINDING PROTEIN; LAYER; POLYELECTROLYTE AB Harnessing the energy transfer interactions between the optical protein bacteriorhodopsin (bR) and CdSe/ZnS quantum dots (QDs) could provide a novel bio-nano electronics substrate with a variety of applications. In the present study, a polydimethyldiallyammonium chloride based I-SAM technique has been utilized to produce bilayers, trilayers and multilayers of alternating monolayers of bR, PDAC and QD's on a conductive ITO substrate. The construction of multilayer systems was directly monitored by measuring the unique A(570) nm absorbance of bR, as well as QD fluorescence emission. Both of these parameters displayed a linear relationship to the number of monolayers present on the ITO substrate. The photovoltaic response of bilayers of bR/PDAC was observed over a range of 3 to 12 bilayers and the ability to efficiently create an electrically active multilayered substrate composed of bR and QDs has been demonstrated for the first time. Evaluation of QD fluorescence emission in the multilayer system strongly suggests that FRET coupling is occurring and, since the I-SAM technique provide a means to control the bR/QD separation distance on the nanometer scale, this technique may prove highly valuable for optimizing the distance dependent energy transfer effects for maximum sensitivity to target molecule binding by a biosensor. Finally, preliminary studies on the production of a sensor protein/bR hybrid gene construct are presented. It is proposed that the energy associated with target molecule binding to a hybrid sensor protein would provide a means to directly modulate the electrical output from a sensor protein/bR biosensor platform. C1 [Griep, Mark; Winder, Eric; Lueking, Donald; Friedrich, Craig] Michigan Technol Univ, Multiscale Technol Inst, Houghton, MI 49931 USA. [Griep, Mark; Mallick, Govind; Karna, Shashi] USA, ATTN AMSRD ARL WM BD, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Friedrich, C (reprint author), Michigan Technol Univ, Multiscale Technol Inst, Houghton, MI 49931 USA. OI Winder, Eric/0000-0003-3707-7549 FU U.S. Army Research Laboratory [DAADI7-03-C-0115]; National Science Foundation Graduate Research FX We thank Dr. Raymond Mackay of the Edgewood Chemical and Biological Center for his assistance in the electrical activity measurements and interpretation. Additionally we thank Dr. Roger LeBlanc and Jianmin Xu of the University of Miami, Chemistry Department for graciously supplying the QDs used in this work. We also thank Chris Anton, Karl Walczak, and Tracy Neher of the Michigan Technological University for their aid and input on various aspects of this project. The research reported in this document was performed in connection with contract DAADI7-03-C-0115 with the U.S. Army Research Laboratory. The views and conclusions contained in this document are those of the authors and should not be interpreted as presenting the official policies or position, either expressed or implied, of the U.S. Army Research Laboratory or the U.S. Government unless so designated by other authorized documents. Citation of manufacturer's or trade names does not constitute an official endorsement or approval of the use thereof. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. A National Science Foundation Graduate Research Fellowship also supported this research. NR 15 TC 4 Z9 4 U1 0 U2 10 PU AMER SCIENTIFIC PUBLISHERS PI VALENCIA PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA SN 1533-4880 EI 1533-4899 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD SEP PY 2010 VL 10 IS 9 BP 6029 EP 6035 DI 10.1166/jnn.2010.2612 PG 7 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 624RA UT WOS:000279836400075 PM 21133143 ER PT J AU Mallick, G Griep, M Lastella, S Sahoo, S Hirsch, S Ajayan, PM Karna, SP AF Mallick, Govind Griep, Mark Lastella, Sarah Sahoo, Sangeeta Hirsch, Samuel Ajayan, Pulickel M. Karna, Shashi P. TI Diode-Like Properties of As-Grown Chemical Vapor Deposited Single-Walled Carbon Nanotubes SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article; Proceedings Paper CT 2nd International Conference on Advanced Nano Materials CT 1st International Conference from Nanoparticles and Nanomaterials to Nanodevices and Nanosystems (1st IC4N) CY 2008 CY JUN 16-18, 2008 CL Univ Aveiro, Aveiro, PORTUGAL CL Halkidiki, GREECE HO Univ Aveiro DE Single-Walled Carbon Nanotube; Current Rectification; Diode ID ELECTRONIC-STRUCTURE AB Current rectification property of as-grown single-walled carbon nanotubes (SWNTs) is investigated. The SWNTs are grown by chemical vapor deposition (CVD) process. The process allowed to grow long strands of SWNT bundles, which are then used to fabricate multiple arrays of switching devices with the channel length of 3, 5, 7 and 10 mu m on a 15 mm x 15 mm SiO2 on Si substrate. Regardless of the channel length, a majority of the fabricated devices show current rectification characteristics, with high throughput of current (I) in the forward bias (V) giving the forward and reverse current ratio (I-for/I-rev) of similar to 10(6). Atomic force microscopic (AFM) analysis of the device structure and surface topology of SWNT suggest the observed rectification of current to possibly result from (a) cross-tube junctions, (b) a mixture of metallic and semiconducting tubes in the SWNT bundles, and/or (c) chirality change along a single tube. The exact mechanism underlying the observed rectification could not be conclusively established. However, the analyses of the experimental results strongly suggest the observed rectification to result from Schottky-type diode properties of SWNTs with mixed chirality along the tube. C1 [Mallick, Govind; Griep, Mark; Hirsch, Samuel; Karna, Shashi P.] USA, Res Lab, ATTN AMSRD ARL WM BD, Dept Army,WMRD, Aberdeen Proving Ground, MD 21005 USA. [Griep, Mark] Michigan Technol Univ, Dept Mech Engn, Houghton, MI 49931 USA. [Lastella, Sarah; Sahoo, Sangeeta; Ajayan, Pulickel M.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. RP Mallick, G (reprint author), USA, Res Lab, ATTN AMSRD ARL WM BD, Dept Army,WMRD, Aberdeen Proving Ground, MD 21005 USA. NR 14 TC 1 Z9 1 U1 0 U2 3 PU AMER SCIENTIFIC PUBLISHERS PI VALENCIA PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA SN 1533-4880 EI 1533-4899 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD SEP PY 2010 VL 10 IS 9 BP 6062 EP 6066 DI 10.1166/jnn.2010.2584 PG 5 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 624RA UT WOS:000279836400081 PM 21133149 ER PT J AU Propper, RE Brunye, TT Christman, SD Bologna, J AF Propper, Ruth E. Brunye, Tad T. Christman, Stephen D. Bologna, Jessica TI Negative Emotional Valence Is Associated With Non-Right-Handedness and Increased Imbalance of Hemispheric Activation as Measured by Tympanic Membrane Temperature SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article DE Handedness; hemispheric asymmetry; emotion; tympanic membrane temperature ID EYE-MOVEMENTS ENHANCE; ASYMMETRIES; STUDENTS; MEMORY; SEX AB We investigated the possibility that individual differences in hand preference influence hemispheric emotional valence asymmetries using the Profile of Mood States Short-Form (Shacham, J Pers Assess. 1983; 47: 305306) as a measure of emotional valence and tympanic membrane temperature (TMT) as a measure of hemispheric activity. We replicate others' findings of increased negative valence in the non-right-handed. We further demonstrate handedness effects on the absolute difference between left and right TMT, and a positive relationship between this measure and the anger/hostility subscale of the Profile of Mood States Short Form. Findings suggest (i) negative emotional valence is associated with extreme asymmetries of cortical activation and (ii) TMT may be a simple means by which emotional state may be indicated, with increased difference between left and right TMT, suggesting increased anger/hostility. These findings offer the possibility of an exceptionally simple measure that may, in conjunction with more established techniques, offer valuable diagnostic information, particularly for disorders involving anger/hostility. C1 [Propper, Ruth E.; Bologna, Jessica] Merrimack Coll, Dept Psychol, N Andover, MA 01845 USA. [Brunye, Tad T.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.] USA, Natick Solidier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Christman, Stephen D.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA. RP Propper, RE (reprint author), Merrimack Coll, Dept Psychol, 315 Turnpike St, N Andover, MA 01845 USA. EM ruth.propper@merrimack.edu FU US Army [W911QY-09-P-0567] FX Supported by US Army Contract W911QY-09-P-0567. NR 23 TC 8 Z9 8 U1 3 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD SEP PY 2010 VL 198 IS 9 BP 691 EP 694 DI 10.1097/NMD.0b013e3181ef1f35 PG 4 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 651JU UT WOS:000281924800015 PM 20823734 ER PT J AU Houston, SKS Weber, ED Koga, SF Newman, SA AF Houston, Samuel K. Steven Weber, Eric D. Koga, Sebastian F. Newman, Steven A. TI Rarebit Perimetry for Bedside Testing: Comparison With Standard Automated Perimetry SO JOURNAL OF NEURO-OPHTHALMOLOGY LA English DT Article ID DOUBLING TECHNOLOGY PERIMETRY; HUMAN EYES; GLAUCOMA; CELLS AB Background: Rarebit perimetry (RBP), a technique developed for the detection of early damage to the afferent visual system, has not been extensively tested at the bedside. This study was designed to test the feasibility of bedside testing with RBP in comparison with standard automated perimetry (SAP) performed in the clinic. Methods: We tested 29 eyes of 15 subjects admitted with neurologic or neurosurgical diseases affecting the afferent visual system. RBP was performed on a laptop computer at the bedside. SAP (Humphrey field analyzer) testing was performed later in the clinic. Results were evaluated by a masked neuro-ophthalmologist. Results: Visual fields corresponded between RBP and SAP in 21(72%) of the 29 tested eyes. RBP detected defects in 5 subjects who had normal visual field results on SAP. All subjects preferred RBP for convenience. Conclusion: RBP is a convenient method of bedside visual field testing and is no less sensitive to visual field defects in this role than SAP. Journal of Neuro-Ophthalmology 2010;30:243-247 doi: 10.1097/WNO.0b013e3181dee88a (C) 2010 by North American Neuro-Ophthalmology Society C1 [Weber, Eric D.; Newman, Steven A.] Univ Virginia, Dept Ophthalmol, Charlottesville, VA 22908 USA. [Koga, Sebastian F.] Univ Virginia, Dept Neurosurg, Charlottesville, VA 22908 USA. [Weber, Eric D.] Walter Reed Army Med Ctr, Dept Ophthalmol, Washington, DC 20307 USA. RP Newman, SA (reprint author), Univ Virginia, Dept Ophthalmol, POB 800715, Charlottesville, VA 22908 USA. EM san7a@virginia.edu RI Koga, Sebastian /J-9314-2016 OI Koga, Sebastian /0000-0002-3034-570X NR 16 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1070-8022 J9 J NEURO-OPHTHALMOL JI J. Neuro-Ophthal. PD SEP PY 2010 VL 30 IS 3 BP 243 EP 247 DI 10.1097/WNO.0b013e3181dee88a PG 5 WC Clinical Neurology; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA 647EU UT WOS:000281601400008 ER PT J AU Martin, JE Teff, RJ Spinella, PC AF Martin, Jonathan E. Teff, Richard J. Spinella, Philip C. TI Care of pediatric neurosurgical patients in Iraq in 2007: clinical and ethical experience of a field hospital Clinical article SO JOURNAL OF NEUROSURGERY-PEDIATRICS LA English DT Article DE deployment neurosurgery; pediatric trauma; penetrating head injury; penetrating spine injury; bioethics ID TRAUMATIC BRAIN-INJURY; DECOMPRESSIVE CRANIECTOMY; LEBANESE CONFLICT; PRACTICAL SCALE; CHILDREN; AFGHANISTAN; MISSION; COMA; WAR AB Object. Care for host-nation pediatric casualties and disease or nonbattle injuries is an essential mission of deployed military medical assets. Clinical experience with pediatric patients at field hospitals has been increasingly reported since 2001, with neurotrauma identified as a major cause of morbidity and death in this population. A concentrated pediatric neurosurgical experience at a deployed medical facility has not been reported. The authors reviewed their experience with pediatric neurosurgical patients at a field hospital in Iraq in 2007 to provide insight into the management of this patient population. Methods. A retrospective review was conducted using a prospective database constructed by the authors for quality improvement during a single combat rotation in 2007. Results. Forty-two patients among 287 consultations were 17 years of age or younger. Twenty-six of these children were 8 years old or younger. Penetrating head injuries were the most common indication for consultation (22 of 42 patients). Twenty-eight of 130 surgical procedures were performed in the children. One patient died in the perioperative period, for a trauma-related operative mortality rate of 4%. Seven patients received palliative care based on the extent of presenting injuries. Twenty-five patients were discharged with minimal or no neurological deficits. Conclusions. Pediatric patients represent a significant proportion of the neurosurgical patient volume at field medical hospitals in the Iraqi theater. The mature medical theater environment present in 2007 allowed for remarkable diagnostic evaluation and treatment of these patients. Penetrating and closed craniospinal injuries were the most common indication for consultation. Disease and nonbattle injuries were also encountered, with care provided when deemed appropriate. The deployed environment presents unique medical and ethical challenges to neurosurgeons serving in forward medical facilities. (DOI: 10.3171/2010.6.PEDS1031) C1 [Martin, Jonathan E.] Univ Connecticut, Sch Med, Dept Surg, Div Neurosurg,Connecticut Childrens Med Ctr, Hartford, CT 06106 USA. [Teff, Richard J.] Univ Connecticut, Sch Med, Dept Pediat, Hartford, CT 06106 USA. [Spinella, Philip C.] Brooke Army Med Ctr, Dept Surg, Div Neurosurg, San Antonio, TX USA. RP Martin, JE (reprint author), Univ Connecticut, Sch Med, Dept Surg, Div Neurosurg,Connecticut Childrens Med Ctr, 282 Washington St, Hartford, CT 06106 USA. EM jmartin03@ccmckids.org NR 24 TC 3 Z9 3 U1 0 U2 2 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1933-0707 J9 J NEUROSURG-PEDIATR JI J. Neurosurg.-Pediatr. PD SEP PY 2010 VL 6 IS 3 BP 250 EP 256 DI 10.3171/2010.6.PEDS1031 PG 7 WC Clinical Neurology; Pediatrics; Surgery SC Neurosciences & Neurology; Pediatrics; Surgery GA 641FT UT WOS:000281110900011 PM 20809709 ER PT J AU Wei, G Lu, XCM Yang, XF Tortella, FC AF Wei, Guo Lu, Xi-Chun M. Yang, Xiaofang Tortella, Frank C. TI Intracranial Pressure following Penetrating Ballistic-Like Brain Injury in Rats SO JOURNAL OF NEUROTRAUMA LA English DT Article DE cerebral perfusion pressure; intracranial pressure; mean arterial blood pressure; penetrating ballistic-like brain injury; rat ID TRAUMATIC BRAIN; GUNSHOT WOUNDS; HEAD-INJURY; ISCHEMIA; NNZ-2566; ANALOG; EDEMA; MODEL AB Penetrating ballistic brain injury involves a leading shockwave producing a temporary cavity causing substantial secondary injury. In response to the prevalence of this type of brain trauma in the military, a rat model of penetrating ballistic-like brain injury (PBBI) was established. This study focuses on cerebral physiological responses resulting from a PBBI, specifically the immediate and delayed changes in intracranial pressure (ICP) and cerebral perfusion pressure (CPP). ICP/CPP was measured continuously in rats subjected to PBBI, probe insertion alone, or sham injury. Immediately following the PBBI, a transient (<0.1 sec) and dramatic elevation of ICP reaching 280.0 +/- 86.0 mm Hg occurred, accompanied by a profound decrease in CPP to -180.2 +/- 90.1 mm Hg. This emergent ICP/CPP response resolved spontaneously within seconds, but was followed by a slowly-developing and sustained secondary phase, which peaked at 24 h post-injury, reaching 37.2 +/- 10.4 mm Hg, and remained elevated until 72 h post-injury. The measured decrease in CPP reached 85.3 +/- 17.2 mm Hg at 3 h post-injury. By comparison, probe insertion alone did not produce the immediate ICP crisis (28.6 +/- 9.1 mm Hg), and only a mild and sustained increase in ICP (13.5 +/- 2.1 mm Hg) was observed in the following 3 h post-injury. Injury severity, as measured by lesion volume, brain swelling, and neurological deficits at 1, 3, and 7 days post-injury, also reflected the distinctive differences between the dynamics of the PBBI versus controls. These results not only reinforced the severe nature of this model in mimicking the ballistic effect of PBBI, but also established cerebral pathophysiological targets for neuroprotective therapies. C1 [Wei, Guo; Lu, Xi-Chun M.; Yang, Xiaofang; Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. RP Wei, G (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Guo.Wei@US.ARMY.MIL NR 26 TC 12 Z9 12 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD SEP PY 2010 VL 27 IS 9 BP 1635 EP 1641 DI 10.1089/neu.2010.1378 PG 7 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 649TJ UT WOS:000281796500010 PM 20568960 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Dmitriy Shkuratov, Yuriy Videen, Gorden TI Application of the Sh-matrices method to light scattering by spheroids SO JOURNAL OF OPTICS LA English DT Article DE scattering; T-matrix; particles ID FINITE-CYLINDER; RAY SCATTERING; PARTICLES; COMPUTATIONS; CAPSULE AB The application of the Sh-matrices technique developed within the T-matrix formalism allows for the derivation of analytic solutions to the light scattering from non-spherical particles. In this paper we derive such solutions for isolated prolate and oblate spheroids. Examples of calculations of spheroid scattering properties including the case of particles with high eccentricity are presented. Our results are compared with corresponding calculations using the discrete dipole approximation (DDA) method and analytical methods based on the separation of variables for the vector wave equations in the spheroidal coordinate system. C1 [Petrov, Dmitriy; Shkuratov, Yuriy] Kharkov Natl Univ, Astron Inst VN Karazin, UA-61022 Kharkov, Ukraine. [Shkuratov, Yuriy] Natl Acad Sci Ukraine, Inst Radioastron, UA-61002 Kharkov, Ukraine. [Videen, Gorden] Army Res Lab AMSRL CI EM, Adelphi, MD 20783 USA. RP Petrov, D (reprint author), Kharkov Natl Univ, Astron Inst VN Karazin, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM petrov@astron.kharkov.ua FU Army Medical Research Institute of Chemical Defense under the US Army Research Office Scientific Services [0378, W911NF-07-D-0001]; CRDF [UKP2-2897-KK-07] FX The authors thank E Zubko for the use of his DDA code. This work was supported by the Army Medical Research Institute of Chemical Defense (Lucille Lumley, PhD) under the auspices of the US Army Research Office Scientific Services Program administered by Battelle (Delivery Order 0378, contract no. W911NF-07-D-0001). This work was also supported by CRDF grant UKP2-2897-KK-07. NR 29 TC 5 Z9 5 U1 2 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2040-8978 EI 2040-8986 J9 J OPTICS-UK JI J. Opt. PD SEP PY 2010 VL 12 IS 9 AR 095701 DI 10.1088/2040-8978/12/9/095701 PG 15 WC Optics SC Optics GA 653XY UT WOS:000282132900017 ER PT J AU Miclau, T Schmidt, AH Wenke, JC Webb, LX Harro, JM Prabhakara, R Shirtliff, ME AF Miclau, Theodore Schmidt, Andrew H. Wenke, Joseph C. Webb, Lawrence X. Harro, Janette M. Prabhakara, Ranjani Shirtliff, Mark E. TI Infection SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Review DE musculoskeletal infection; biofilm; bacteria; biomaterial ID STABILIZED SEGMENTAL DEFECT; RAT FEMUR; BONE-FORMATION; BIOFILMS; RHBMP-2; MODEL AB Musculoskeletal infection is a clinical problem with significant direct healthcare costs The prevalence of infection after closed, elective surgery is frequently estimated to be less than 2%. but in se ere injuries. pot:mum:ale infection rates have been reported as 10% or greater Although clinical infections are found outside the realm of medical devices, it is deal that the enormous increase of infections associated with the use of implants presents a major challenge worldwide This review summarizes recent advances in the understanding. diagnosis, and treatment of musculoskeletal Infections C1 [Miclau, Theodore] Univ Calif San Francisco, San Francisco Gen Hosp, Orthopaed Trauma Inst, Dept Orthopaed Surg, San Francisco, CA 94110 USA. [Schmidt, Andrew H.] Univ Minnesota, Dept Orthopaed Surg, Hennepin Cty Med Ctr, Minneapolis, MN 55455 USA. [Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Webb, Lawrence X.] Med Ctr Cent Georgia, Georgia Orthopaed Trauma Inst, Macon, GA USA. [Harro, Janette M.; Prabhakara, Ranjani; Shirtliff, Mark E.] Univ Maryland, Dept Microbial Pathogenesis, Baltimore, MD 21201 USA. RP Miclau, T (reprint author), Univ Calif San Francisco, San Francisco Gen Hosp, Orthopaed Trauma Inst, Dept Orthopaed Surg, 2550 23rd St,Bldg 9,2nd Floor, San Francisco, CA 94110 USA. FU NIAID NIH HHS [R01 AI069568] NR 19 TC 16 Z9 17 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD SEP PY 2010 VL 24 IS 9 BP 583 EP 586 PG 4 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 647FL UT WOS:000281603100015 PM 20736799 ER PT J AU Stinner, DJ Noel, SP Haggard, WO Watson, JT Wenke, JC AF Stinner, Daniel J. Noel, Scott P. Haggard, Warren O. Watson, J. Tracy Wenke, Joseph C. TI Local Antibiotic Delivery Using Tailorable Chitosan Sponges: The Future of Infection Control? SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE open fracture; infection; contamination; antibiotics; local delivery ID IN-VITRO EVALUATION; IRRIGATION; SUBSTITUTE; MANAGEMENT; FRACTURES; THERAPY; MODEL AB Objectives: Local antibiotic delivery is a viable and attractive option for preventing infection Unfortunately, the current options are limited and often necessitate surgical removal This study evaluates the ability of a biodegradable and biocompatible chitosan sponge to minimize infection by delivering local antibiotics within the wound Methods: A.. complex musculoskeletal wound was created on the hindlimb of goats and contaminated with Pseudomonas aeruguiosa (lux) or Staphylococcus aureus (lux) bacteria These bacteria arc genetically engineered to emit photons, allowing for quantification with a photon-counting camera system The wounds were closed and similarly debrided and irrigated with 9 L normal saline using bulb-syringe irrigation 6 hours alter inoculation Goats were assigned to different treatment groups a control group with no adjunctive treatment and an experimental group using a chitosan sponge loaded with either amikacin (for wounds contaminated with P aeruginosa) or vancomycin (for wounds contaminated with S aureus) The wounds were closed after the procedure and evaluated 48 hours alter initial contamination Serum levels of the antibiotics were also measured at 6. 12. 24, 36, and 42 hours after treatment was initiated Results: The wounds treated with the antibiotic-loaded chitosan sponge had significantly less bacteria than the untreated wounds (P < 0 05) The highest serum levels were 6 hours after treatment but remained less than 15% of target serum levels for systemic treatment At study end point, all sponges were between 60% and 100% degraded Conclusions: The chitosan sponges are effective delivering the antibiotic and reducing the bacteria within the wounds C1 [Wenke, Joseph C.] USA, Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA. [Noel, Scott P.; Haggard, Warren O.] Univ Memphis, Dept Biomed Engn, Memphis, TN 38152 USA. [Watson, J. Tracy] St Louis Univ, Sch Med, Div Orthopaed Traumatol, St Louis, MO USA. RP Wenke, JC (reprint author), USA, Inst Surg Res, Dept Regenerat Med, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. FU Department of Defense [W81XWH-08-1-0312] FX This study was funded through a Department of Defense grant (Orthopaedic Extremity Trauma Research Program #W81XWH-08-1-0312) NR 20 TC 24 Z9 24 U1 2 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD SEP PY 2010 VL 24 IS 9 BP 592 EP 597 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 647FL UT WOS:000281603100017 PM 20736801 ER PT J AU Lalliss, SJ Stinner, DJ Waterman, SM Branstetter, JG Masini, BD Wenke, JC AF Lalliss, Steven J. Stinner, Daniel J. Waterman, Scott M. Branstetter, Joanna G. Masini, Brendan D. Wenke, Joseph C. TI Negative Pressure Wound Therapy Reduces Pseudomonas Wound Contamination More Than Staphylococcus aureus SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE contamination; infection; open fracture; trauma; negative pressure; wound management; acute care ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES AB Purpose: The purpose of this study is to determine if negative pressure wound therapy (NPWT) treatment results in fewer bacteria than wet-to-dry., (WTD) dressings in a contaminated open fracture wound model Methods: For Study Study I. complex wounds were created on the proximal left leg of goats The wounds were inoculated with Pseudomonas aeruginosa The wounds were debrided and irrigated 6 hours after inoculation The first group received WTD dressing chanties twice daily, the second and third groups received NPWT using systems from two different companies All three groups received repeat debridements every 48 hours for 6 days Bacteria quantification was performed both immediately before and after each dabridement For Study 2, the only changes were that Staphylococcus aureus was used and only one NPWT group was included Results: In Study I. there were significantly fewer Pseudomonas in both NPWT groups at all imaging sessions after the initial dabridement and irrigation At the 6-day time point. the wounds in the NPWT groups were 43 +/- 14% and 68 +/- 6% of the baseline amount, respectively The WTD groups were 464 +/- 102% of the baseline amount In Study 2, NPWT did not reduce the S aureus contamination within the wound At the 6-day time point, the wounds in the NPWT and WTD groups contained 115 +/- 19% and 192 +/- 52% of the baseline values. respectively Conclusion: NPWT showed a significant and sustained decrease in the Pseudomonas levels compared with WTD dressings at all time points This beneficial effect was seen not seen in S aureus C1 [Lalliss, Steven J.; Stinner, Daniel J.; Waterman, Scott M.; Branstetter, Joanna G.; Masini, Brendan D.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Wenke, JC (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 16 TC 42 Z9 46 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD SEP PY 2010 VL 24 IS 9 BP 598 EP 602 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 647FL UT WOS:000281603100018 PM 20736802 ER PT J AU Shah, S Hudak, J Gad, A Cohen, JC Chander, A AF Shah, Shetal Hudak, Joseph, III Gad, Ashraf Cohen, J. Craig Chander, Avinash TI Simulated transport alters surfactant homeostasis and causes dose-dependent changes in respiratory function in neonatal Sprague-Dawley rats SO JOURNAL OF PERINATAL MEDICINE LA English DT Article DE Positive end expiratory pressure; pressure-volume curve; Sprague-Dawley rat pups; transport ID NECROSIS-FACTOR-ALPHA; INTRAVENTRICULAR HEMORRHAGE; BRONCHOPULMONARY DYSPLASIA; AMNIOTIC-FLUID; II CELLS; INTERHOSPITAL TRANSPORT; PREMATURE-INFANTS; TISSUE MECHANICS; PRETERM INFANTS; RISK AB Objective: Forces transmitted to the neonate as a consequence of accelerations during transport have been associated with adverse neonatal outcomes including bronchopulmonary dysplasia. In this study, we sought to determine the relationship between the duration of transport and respiratory performance in the rat model. Methods: Four groups of Sprague-Dawley rat pups (10-12 pups/groups) were exposed to simulated medical transport on postnatal day of life 11 or 12. Each group was exposed to an average impulse of 27.4 m/s(2)/min for 0, 30, 60 or 90 min. During the exposure periods, impulse was monitored by computerized sampling using a digital accelerometer. Post-exposure, animals were immediately prepared, placed on mechanical ventilation and analyzed for elastance, tissue damping, airway resistance, ratio of damping to elastance (eta), hysteresivity, and inertance at positive end expiratory pressures (PEEPs) of 0, 3 and 6 cm(3) of H(2)O. Total phospholipid content and surfactant proteins A, B, and C mRNA levels in broncho-alveolar lavage fluid and lung tissue were obtained. Results: Increased transport time resulted in a significant step-wise increase in airway resistance at all levels of PEEP (P<0.01). Static compliance decreased significantly after 60 min at PEEPs of 3 and 6 cm H(2)O (P<0.01). Eta significantly decreased with greater transport time at a PEEP of 6 cm H(2)O (P<0.05). Tissue damping increased with duration of transport time across all PEEP levels, but only exhibited statistical significance at a PEEP of 0 cm H(2)O (P<0.05). No differences were seen in hysteresivity or inertance. Compared with controls, transport was associated with significant reductions in total phospholipid content and mRNA levels of surfactant proteins B and C. Conclusion: Rat pups experienced significant deterioration of respiratory function with increasing duration of simulated transport. C1 [Shah, Shetal; Cohen, J. Craig; Chander, Avinash] SUNY Stony Brook, Dept Pediat, Div Neonatol, Brady William Russell Lab, Stony Brook, NY 11794 USA. [Hudak, Joseph, III] USA, Tripler Med Ctr, Div Med Sci, Honolulu, HI USA. [Gad, Ashraf] New York Methodist Hosp, Dept Pediat, Div Neonatol, New York, NY USA. RP Shah, S (reprint author), SUNY Stony Brook, Dept Pediat, Div Neonatol, Brady William Russell Lab, Stony Brook, NY 11794 USA. EM shetaldoc@hotmail.com FU NHLBI NIH HHS [R01 HL049959, HL 049959] NR 50 TC 2 Z9 2 U1 0 U2 1 PU WALTER DE GRUYTER & CO PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0300-5577 J9 J PERINAT MED JI J. Perinat. Med. PD SEP PY 2010 VL 38 IS 5 BP 535 EP 543 DI 10.1515/JPM.2010.080 PG 9 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 646TT UT WOS:000281566600013 PM 20629492 ER PT J AU Convertino, VA Cap, AP AF Convertino, Victor A. Cap, Andrew P. TI Should patients with haemorrhage be kept warm? SO JOURNAL OF PHYSIOLOGY-LONDON LA English DT Editorial Material ID FAILING HEART; CONTRACTION; MECHANISMS C1 [Convertino, Victor A.; Cap, Andrew P.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil NR 6 TC 6 Z9 6 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-3751 J9 J PHYSIOL-LONDON JI J. Physiol.-London PD SEP 1 PY 2010 VL 588 IS 17 BP 3135 EP 3135 DI 10.1113/jphysiol.2010.196733 PG 1 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 646OY UT WOS:000281553100003 PM 20810359 ER PT J AU Bautista, CT Todd, CS Abed, AMS Botros, BA Strathdee, SA Earhart, KC Safi, N Scott, PT AF Bautista, Christian T. Todd, Catherine S. Abed, Abdullah M. S. Botros, Boulos A. Strathdee, Steffanie A. Earhart, Kenneth C. Safi, Naqibullah Scott, Paul T. TI Effects of duration of injection drug use and age at first injection on HCV among IDU in Kabul, Afghanistan(dagger) SO JOURNAL OF PUBLIC HEALTH LA English DT Article DE Afghanistan; age; duration; first injection; HCV; IDU; risk ID HEPATITIS-C VIRUS; RISK-FACTORS; INFECTION; PREVALENCE; HIV; PROGRAMS; SEROCONVERSION; TRANSMISSION; INITIATION; EQUIPMENT AB Hepatitis C virus (HCV) prevalence is high among injection drug users (IDUs) in Afghanistan. Duration of injection and young age at first injection are common risk factors for HCV in IDU populations. The association of HCV with these time factors was analyzed. Socio-demographic and drug use behavior information were collected. Participants had rapid testing for HCV with recombinant immunoblot assay confirmation. Modeling of non-linear associations was performed using fractional polynomial logistic regression. Among 459 male IDUs, age at first injection had a constant HCV risk (odds ratio (OR): 1.01 per year; 95% confidence interval (CI): 0.98-1.03), while each additional year of injection drug use had a significantly increased risk (OR: 4.72 per year, 95% CI: 2.92-7.66). HCV risk increased significantly with each additional year of injecting drug use by groups of injectors: young (< 22 years, OR: 1.97; 95% CI: 1.27-3.07), middle (23-28 years, OR: 1.76; 95% CI: 1.28-2.43) and older (>= 29 years, OR: 7.56; 95% CI: 3.15-18.14). The probability of HCV infection increased markedly by duration of injection drug use and varied according to age at first injection. Drug counseling and educational efforts should be directed to older drug users who have not yet initiated injecting and to young IDUs to avert infection and reduce risky drug use behaviors. C1 [Bautista, Christian T.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, Rockville, MD USA. [Todd, Catherine S.; Strathdee, Steffanie A.] Univ Calif San Diego, Div Int Hlth & Cross Cultural Med, San Diego, CA 92103 USA. [Abed, Abdullah M. S.] Minist Publ Hlth, Natl AIDS Control Program, Kabul, Afghanistan. [Botros, Boulos A.; Earhart, Kenneth C.; Safi, Naqibullah] USN, Med Res Unit 3, Virol Res Program, Cairo, Egypt. RP Bautista, CT (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, Rockville, MD USA. EM cbautista@hivresearch.org RI Bautista, Christian/B-2812-2011 FU Walter Reed Army Institute of Research (WRAIR) [1176, RV182] FX This work was supported by the Walter Reed Army Institute of Research (WRAIR # 1176, RV182). NR 27 TC 7 Z9 8 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1741-3842 J9 J PUBLIC HEALTH-UK JI J. Public Health PD SEP PY 2010 VL 32 IS 3 BP 336 EP 341 DI 10.1093/pubmed/fdq020 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 642EG UT WOS:000281186000010 PM 20421237 ER PT J AU Arciero, CA AF Arciero, Cletus A. TI Ki-67 Proliferation Index and Gastric Cancer: Answers or More Questions SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Editorial Material ID C COLON-CANCER; PROGNOSTIC VALUE; BREAST; P53 C1 Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Arciero, CA (reprint author), Dwight D Eisenhower Army Med Ctr, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM cletus.arciero@us.army.mil NR 5 TC 2 Z9 2 U1 0 U2 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD SEP 1 PY 2010 VL 102 IS 3 BP 199 EP 200 DI 10.1002/jso.21626 PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 643JB UT WOS:000281290300001 PM 20740573 ER PT J AU Marsh, CP Bushman, JB AF Marsh, Charles P. Bushman, James B. TI Experimental Determination of Galvanic Anode Current Output for Common Geometries Used in Civil Works Applications SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE galvanic anodes; current output; cathodic protection design; civil works AB The current output from various common galvanic (sacrificial) anode geometries used in immersion service was experimentally determined. The results showed a specific functional dependence on exposed surface area and a scalable inverse relationship to the resistivity of the surrounding electrolyte medium. The use of this information as applied to cathodic protection design is also presented using three of the most readily available freshwater sacrificial anode metal alloys. C1 [Marsh, Charles P.] Univ Illinois, US Army Corps Engineers ERDC CERL, Champaign, IL 61822 USA. [Marsh, Charles P.] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Champaign, IL 61822 USA. [Bushman, James B.] Bushman & Associates Inc, Medina, OH 44258 USA. RP Marsh, CP (reprint author), Univ Illinois, US Army Corps Engineers ERDC CERL, 2902 Newmark Dr, Champaign, IL 61822 USA. EM charles.p.marsh@usace.army.mil; james@bushman.cc FU Headquarters, U.S. Army Corps of Engineers FX Funding by Headquarters, U.S. Army Corps of Engineers, is gratefully acknowledged. The primary purpose of this work was to develop improved design criteria for cathodic protection of freshwater lock and dam structures. Illuminating discussions of applicable theory with Dr. Carl A. Feickert are also acknowledged. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0090-3973 EI 1945-7553 J9 J TEST EVAL JI J. Test. Eval. PD SEP PY 2010 VL 38 IS 5 BP 641 EP 646 DI 10.1520/JTE102139 PG 6 WC Materials Science, Characterization & Testing SC Materials Science GA 652UD UT WOS:000282034800015 ER PT J AU Wilkins, T Gillies, RA Getz, A Zimmerman, D Kang, L AF Wilkins, Thad Gillies, Ralph A. Getz, April Zimmerman, Dave Kang, Larry TI Nasolaryngoscopy in a Family Medicine Clinic: Indications, Findings, and Economics SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Article DE Laryngoscopy; Laryngeal Neoplasms; Laryngopharyngeal Reflux; Primary Health Care ID SELF-REPORTED SMOKING; PREVALENCE; DISEASE AB Background: Nasopharyngeal complaints are common among patients who present to primary care. Patients with these complaints are often referred for nasolaryngoscopy evaluation to exclude serious conditions such as laryngeal cancer. Methods: This study is a retrospective case series in which 276 charts of adult outpatients who were referred for nasolaryngoscopy were reviewed. We examined patient demographics, procedure indications and findings, complications, and changes in clinical management. Results: Nasolaryngoscopy was completed in 273 (98.9%) patients (mean age, 51.3 +/- 14.6 years; 71.4% were women). The most common indications for nasolaryngoscopy were hoarseness (51.3%), globus sensation (32.0%), and chronic cough (17.1%); the most common findings included laryngopharyngeal reflux (42.5%), chronic rhinitis (32.2%), and vocal cord lesions (13.2%). Three patients (1.1%) were diagnosed with laryngeal cancer and this diagnosis was significantly associated with a history of smoking (P = .03). No major complications occurred. Conclusions: We found that nasolaryngoscopy was a safe procedure in the primary care setting, and no major complications occurred in our series. Patients who have ever smoked and complain of hoarseness are at higher risk for laryngeal cancer. An alarming 1% of patients in our series were diagnosed with laryngeal cancer. This is the first study to define the rates of laryngopharyngeal reflux, vocal cord lesions, and laryngeal cancer among primary care patients. (J Am Board Fam Med 2010; 23: 591-597.) C1 [Wilkins, Thad; Gillies, Ralph A.; Getz, April; Zimmerman, Dave] Med Coll Georgia, Dept Family Med, Augusta, GA 30912 USA. [Kang, Larry] Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Wilkins, T (reprint author), Med Coll Georgia, Dept Family Med, 1120 15th St,HB 4032, Augusta, GA 30912 USA. EM twilkins@mcg.edu RI Wilkins, Thad/G-2541-2010 NR 12 TC 5 Z9 5 U1 0 U2 0 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD SEP PY 2010 VL 23 IS 5 BP 591 EP 597 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 647NQ UT WOS:000281625600006 PM 20823353 ER PT J AU Ottomann, C Hartmann, B Tyler, J Maier, H Thiele, R Schaden, W Stojadinovic, A AF Ottomann, Christian Hartmann, Bernd Tyler, Josh Maier, Heike Thiele, Richard Schaden, Wolfgang Stojadinovic, Alexander TI Prospective Randomized Trial of Accelerated Re-epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID VACUUM-ASSISTED CLOSURE; CELL-PROLIFERATION; ISCHEMIC NECROSIS; FLAP MODEL; WOUNDS; RECRUITMENT; SURVIVAL; INCREASE; ULCERS; FOOT AB BACKGROUND: Extracorporeal shock wave therapy may enhance revascularization and repair of healing soft tissue. METHODS: Between January 2006, and September 2007, 28 patients with acute traumatic wounds and burns requiring skin grafting were randomly assigned in a 1:1 fashion to receive standard topical therapy (nonadherent silicone mesh [Mepitel, Molnlycke Health Care] and antiseptic gel [polyhexanide/octenidine]) to graft donor sites with (n = 13) or without (n = 15) defocused extracorporeal shock wave therapy (ESWT, 100 impulses/cm(2) at 0.1 mJ/mm(2)) applied once to the donor site, immediately after skin harvest. The randomization sequence was computer generated, and the patients were blinded to treatment allocation. The primary endpoint was time to complete donor site epithelialization and was determined by an independent blinded observer. RESULTS: Statistical tests indicated no unbalanced distribution of subject characteristics across the two study groups. Mean times to complete graft donor site epithelialization for patients who did and did not undergo ESWT were 13.9 +/- 2.0 days and 16.7 +/- 2.0 days, respectively (p = 0.0001). CONCLUSIONS: For centers that apply nonadherent gauze dressings and topical antiseptics to skin graft donor sites, application of a single defocused shock wave treatment immediately after skin graft harvest can significantly accelerate donor site epithelialization. (J Am Coll Surg 2010;211:361-367. (C) 2010 by the American College of Surgeons) C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA. [Ottomann, Christian; Hartmann, Bernd] Unfallkrankenhaus Berlin, Zentrum Schwerbrandverletzte Plast Chirurg, Berlin, Germany. [Maier, Heike] Free Univ Berlin, Klinikum Rudolf Virchow, Robert Rossle Klin, Charite Berlin, D-13122 Berlin, Germany. [Thiele, Richard] Int Zentrum Stosswellentherapie, Berlin, Germany. [Tyler, Josh] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [Schaden, Wolfgang] AUVA Trauma Ctr Meidling, Vienna, Austria. [Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, 6900 Georgia Ave,Room 5C27A NW, Washington, DC 20307 USA. EM alexander.stojadinovic@amedd.army.mil FU Combat Wound Initiative Program, Washington, DC; Internationales Zentrum fur Stosswellentherapie, Berlin, Germany FX Supported, in part, by the Combat Wound Initiative Program, Washington, DC and the Internationales Zentrum fur Stosswellentherapie, Berlin, Germany. NR 20 TC 27 Z9 27 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2010 VL 211 IS 3 BP 361 EP 367 DI 10.1016/j.jamcollsurg.2010.05.012 PG 7 WC Surgery SC Surgery GA 648QH UT WOS:000281708500009 PM 20800193 ER PT J AU Bennett, JW Robertson, JL Hospenthal, DR Wolf, SE Chung, KK Mende, K Murray, CK AF Bennett, Jason W. Robertson, Janelle L. Hospenthal, Duane R. Wolf, Steven E. Chung, Kevin K. Mende, Katrin Murray, Clinton K. TI Impact of Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Infections in Severely Burned Patients SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID BLOOD-STREAM INFECTIONS; ESCHERICHIA-COLI; RISK-FACTORS; MORTALITY; OUTCOMES; BACTEREMIA; ENTEROBACTERIACEAE; EPIDEMIOLOGY; RESISTANCE; THERAPY AB BACKGROUND: Significantly higher mortality has been demonstrated in patients who suffer severe burns complicated by Klebsiella pneumoniae bacteremia. The specific virulence mechanisms associated with this organism in this population are unclear. STUDY DESIGN: Our study assessed the impact of the mechanism of antibiotic resistance, strain clonality, and other host factors on morbidity and mortality. All patients with thermal burns infected with K pneumoniae between January 1, 2004 and July 1, 2008 were included in the analysis. RESULTS: Ninety-one patients had 111 episodes of K pneumoniae infections, with 59 isolates among the 91 patients producing extended spectrum beta-lactamase (ESBL). Patients with ESBL-producing strains were slightly younger, had higher Injury Severity Scores (ISS), and higher percent full thickness burns. Those who survived to discharge were younger (p < 0.001), had less burned surface area (p = 0.013), had fewer ventilator days (p = 0.016), and fewer infections with ESBL-producing isolates (p = 0.042). Logistic regression revealed that an infection with ESBL-producing K pneumoniae during the hospital stay was the factor most predictive of death, with a nearly 4-fold increased odds of dying. However, survival duration analysis of the population with and without ESBL-producing K pneumoniae using Kaplan-Meier technique showed no significant difference in the populations. Cox regression proportional hazards model revealed that only age (p = 0.01) and ventilator days (p <= 0.01) were associated with time to death. No specific clonality of the strains tested or ESBL production resistance genes were associated with mortality or ESBL production. CONCLUSIONS: These results suggest that infections caused by ESBL-producing K pneumoniae are predictive of death when occurring in an older, more badly burned population. (J Am Coll Surg 2010;211:391-399. (C) 2010 by the American College of Surgeons) C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, LTC,MC,USA, Ft Sam Houston, TX 78234 USA. [Bennett, Jason W.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Wolf, Steven E.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, LTC,MC,USA, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil RI Bennett, Jason/B-3547-2011; Valle, Ruben/A-7512-2013; OI Wolf, Steven/0000-0003-2972-3440 NR 20 TC 8 Z9 8 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2010 VL 211 IS 3 BP 391 EP 399 DI 10.1016/j.jamcollsurg.2010.03.030 PG 9 WC Surgery SC Surgery GA 648QH UT WOS:000281708500013 PM 20800197 ER PT J AU Kreishman, P Kragh, JF Spinella, PC Patel, B Via, K Gillespie, D Mahoney, P Fox, CJ AF Kreishman, Peter Kragh, John F. Spinella, Philip C. Patel, Bhavin Via, Katherine Gillespie, David Mahoney, Peter Fox, Charles J. TI Early management of high velocity pediatric vascular injuries: humanitarian surgical care during US military operations SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT Annual Clinical Congress of American-College-of-Surgeons CY 2010 CL Chicago, IL SP Amer Coll Surg C1 [Kreishman, Peter; Kragh, John F.; Spinella, Philip C.; Patel, Bhavin; Via, Katherine; Gillespie, David; Mahoney, Peter; Fox, Charles J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2010 VL 211 IS 3 SU S BP S145 EP S145 PG 1 WC Surgery SC Surgery GA 648QI UT WOS:000281708600335 ER PT J AU Malin, EW Lairet, K Huzar, T Willaims, J Scott, D Galin, C Renz, E Wolf, S AF Malin, Edward W. Lairet, Kim Huzar, Todd Willaims, James Scott, Dan Galin, Chaya Renz, Evan Wolf, Steven TI Prospective, randomized, controlled study of the efficacy of a silver-coated nylon dressing plus active or sham DC microcurrent for healing of autogenous skin donor sites SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT Annual Clinical Congress of American-College-of-Surgeons CY 2010 CL Chicago, IL SP Amer Coll Surg C1 [Malin, Edward W.; Lairet, Kim; Huzar, Todd; Willaims, James; Scott, Dan; Galin, Chaya; Renz, Evan; Wolf, Steven] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2010 VL 211 IS 3 SU S BP S101 EP S101 PG 1 WC Surgery SC Surgery GA 648QI UT WOS:000281708600224 ER PT J AU Mase, VJ Baer, DG Wade, CE Eastridge, BJ Walters, TW AF Mase, Vincent J., Jr. Baer, David G. Wade, Charles E. Eastridge, Brian J. Walters, Thomas W. TI Admission physiology criteria upon presentation to combat support hospitals; are current critical vital signs effective? SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT Annual Clinical Congress of American-College-of-Surgeons CY 2010 CL Chicago, IL SP Amer Coll Surg C1 [Mase, Vincent J., Jr.; Baer, David G.; Wade, Charles E.; Eastridge, Brian J.; Walters, Thomas W.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2010 VL 211 IS 3 SU S BP S106 EP S106 PG 1 WC Surgery SC Surgery GA 648QI UT WOS:000281708600237 ER PT J AU Simmons, J Chung, KK White, CE Hardin, MO Ritchie, JD Jones, JA Renz, EM Wolf, SE Wade, CE Blackbourne, LH AF Simmons, John Chung, Kevin K. White, Christopher E. Hardin, Mark O. Ritchie, John D. Jones, John A. Renz, Evan M. Wolf, Steven E. Wade, Charles E. Blackbourne, Lorne H. TI Acute kidney injury in burn intensive care unit patients: RIFLE vs AKIN classification SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT Annual Clinical Congress of American-College-of-Surgeons CY 2010 CL Chicago, IL SP Amer Coll Surg C1 [Simmons, John; Chung, Kevin K.; White, Christopher E.; Hardin, Mark O.; Ritchie, John D.; Jones, John A.; Renz, Evan M.; Wolf, Steven E.; Wade, Charles E.; Blackbourne, Lorne H.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2010 VL 211 IS 3 SU S BP S106 EP S106 PG 1 WC Surgery SC Surgery GA 648QI UT WOS:000281708600236 ER PT J AU Tyler, J Clive, K White, C Beekley, A AF Tyler, Joshua Clive, Kevin White, Christopher Beekley, Alec TI Current US military operations and implications for military surgical training SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT Annual Clinical Congress of American-College-of-Surgeons CY 2010 CL Chicago, IL SP Amer Coll Surg C1 [Tyler, Joshua; Clive, Kevin; White, Christopher; Beekley, Alec] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2010 VL 211 IS 3 SU S BP S112 EP S112 PG 1 WC Surgery SC Surgery GA 648QI UT WOS:000281708600252 ER PT J AU Green, DL Boonstra, JA Bober, MA AF Green, David L. Boonstra, Jan A. Bober, Marlene A. TI Use of a codified medication process for documentation of home medications SO JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION LA English DT Article ID HOSPITAL ADMISSION; HEALTH-CARE; RECONCILIATION; ERRORS; SYSTEM; IMPLEMENTATION; DISCREPANCIES; HISTORIES AB To determine the quality and completeness of the list of home medications documented by nurses using a codified process, authors conducted a comparative study of home medications using a non-codified and codified process for documentation of required data fields including drug, dose, route of administration, frequency, and schedule. Each documented home medication (DHM) was evaluated based on the ability to convert to an inpatient medication order. The home medication was classified as non-convertible if one or more of the required data fields were missing, inaccurate, or incomplete. The study compared 176 patients with 1618 OHM in the non-codified group to 94 patients with 646 DHM in the codified group. All DHM could be converted to inpatient orders for 70% of the patients in the codified group compared with 42% in the non-codified group. Based on each DHM, the codified process resulted in 92% of the OHM being able to convert to inpatient orders compared with 82% for the non-codified process. Authors conclude that use of a codified process to document home medications has the potential to increase the number of complete drug entries and in the number of patients with a DHM list in which all of the medication entries have all of the dosing information. C1 [Green, David L.] Walter Reed Army Med Ctr, Dept Pharm Serv, Washington, DC 20307 USA. [Boonstra, Jan A.; Bober, Marlene A.] Advocate Good Samaritan Hosp, Downers Grove, IL USA. RP Green, DL (reprint author), Walter Reed Army Med Ctr, Dept Pharm Serv, Rm 2P02,6900 Georgia Ave NW, Washington, DC 20307 USA. EM david.l.green1@us.army.mil NR 19 TC 2 Z9 2 U1 2 U2 6 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1067-5027 J9 J AM MED INFORM ASSN JI J. Am. Med. Inf. Assoc. PD SEP PY 2010 VL 17 IS 5 BP 608 EP 612 DI 10.1136/jamia.2009.001453 PG 5 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Information Science & Library Science; Medical Informatics SC Computer Science; Information Science & Library Science; Medical Informatics GA 652AM UT WOS:000281972200023 PM 20819872 ER PT J AU Florin, DA Lawyer, P Rowton, E Schultz, G Wilkerson, R Davies, SJ Lipnick, R Keep, L AF Florin, David A. Lawyer, Phillip Rowton, Edgar Schultz, George Wilkerson, Richard Davies, Stephen J. Lipnick, Robert Keep, Lisa TI POPULATION DYNAMICS OF LUTZOMYIA SHANNONI (DIPTERA: PSYCHODIDAE) AT THE PATUXENT NATIONAL WILDLIFE RESEARCH REFUGE, MARYLAND SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Sand fly; Lutzomyia shannoni; seasonal abundance; Patuxent NWRR; Ossabaw Island; San Felasco Hammock Preserve State Park AB The seasonal abundance and temporal patterns of the adult sand fly (Lutzomyia shannoni Dyar) were examined at the Patuxent National Wildlife Research Refuge, MD, from August 3, 2005, to July 29, 2006. A total of 138 (53 males, 85 females) L. shannoni was collected from 4 dry ice-baited traps set at the same 4 locations throughout the study. The male: female ratio was 1: 2.4. All 4 traps, separated by a maximum distance of approximately 1.6 km, operated simultaneously on the collection dates. The collection dates were spaced apart by near weekly intervals during the months of expected sand fly activity. No collections occurred in December-February. August was clearly the period of peak adult abundance as the numbers collected were significantly greater during this month than any other month of collection. Results indicate the existence of a unimodal pattern of abundance with adult emergence beginning in June and ending by September. The temporal pattern and abundance differ from what has been observed for the species on Ossabaw Island, a barrier island located along coastal Georgia, and at San Felasco Hammock Preserve State Park, Gainesville, FL. Continued research is needed to compile multiyear data to confirm the temporal abundance patterns of this species in Maryland. C1 [Florin, David A.; Schultz, George; Davies, Stephen J.; Keep, Lisa] Univ Hlth Sci, Uniformed Serv, Dept Prevent Med & Biometr, Bethesda, MD USA. [Lawyer, Phillip] NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA. [Rowton, Edgar; Wilkerson, Richard] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Lipnick, Robert] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. RP Florin, DA (reprint author), Univ Hlth Sci, Uniformed Serv, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD USA. FU United States Fish and Wildlife Service; Uniformed Services University of the Health Sciences [R087WB] FX We gratefully acknowledge Holliday H. Obrecht III, Wildlife Biologist, United States Fish and Wildlife Service, Region 5, Patuxent Research Refuge, for his assistance and support of this project. This research was funded by the Uniformed Services University of the Health Sciences intramural grant R087WB: Risk for domestic transmission of leishmaniasis acquired by US service members in Iraq/Afghanistan. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. This work was prepared as part of official military duties of the lead author. Title 17 U.S.C. 1105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U.S.C. 1101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. NR 13 TC 0 Z9 0 U1 0 U2 3 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 2010 VL 26 IS 3 BP 337 EP 339 DI 10.2987/10-6022.1 PG 3 WC Entomology SC Entomology GA V24DP UT WOS:000208391400015 PM 21033063 ER PT J AU Hurst, FP Abbott, KC Raj, D Krishnan, M Palant, CE Agodoa, LY Jindal, RM AF Hurst, Frank P. Abbott, Kevin C. Raj, Dominic Krishnan, Mahesh Palant, Carlos E. Agodoa, Lawrence Y. Jindal, Rahul M. TI Arteriovenous Fistulas among Incident Hemodialysis Patients in Department of Defense and Veterans Affairs Facilities SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID VASCULAR ACCESS USE; UNITED-STATES; COST-ANALYSIS; SURVIVAL; CARE; OUTCOMES; QUALITY; CHOICE; SYSTEM; IMPACT AB A higher proportion of patients initiate hemodialysis (HD) with an arteriovenous fistula (AVF) in countries with universal health care systems compared with the United States. Because federally sponsored national health care organizations in the United States, such as the Department of Veterans Affairs (DVA) and the Department of Defense (DoD), are similar to a universal health care model, we studied AVF use within these organizations. We used the US Renal Data System database to perform a cross-sectional analysis of patients who initiated HD between 2005 and 2006. Patients who received predialysis nephrology care had 10-fold greater odds of initiating dialysis with an AVF (adjusted odds ratio [aOR] 10.3; 95% confidence interval [CI] 9.6 to 11.1). DVA/DoD insurance also independently associated with initiating HD with an AVF (aOR 1.4; 95% CI 1.2 to 1.5). Fewer patients initiated HD at a DoD facility, but these patients were also approximately twice as likely to use an AVF (aOR 2.3; 95% CI 1.2 to 4.6). In conclusion, patients in DVA/DoD systems are significantly more likely to use an AVF at initiation of HD than patients with other insurance types, including Medicare. Further study of these federal systems may identify practices that could improve processes of care across health care systems to increase the number of patients who initiate HD with an AVF. C1 [Hurst, Frank P.] Walter Reed Army Med Ctr, Dept Med Nephrol, Serv Nephrol, Washington, DC 20037 USA. [Jindal, Rahul M.] Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20037 USA. [Hurst, Frank P.; Abbott, Kevin C.; Jindal, Rahul M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Raj, Dominic; Palant, Carlos E.; Jindal, Rahul M.] George Washington Univ, Div Renal Dis & Hypertens, Washington, DC USA. [Krishnan, Mahesh] Davita Clin Res, Washington, DC USA. [Palant, Carlos E.] Vet Affairs Med Ctr, Serv Nephrol, Washington, DC 20422 USA. [Agodoa, Lawrence Y.] NIDDKD, NIH, Bethesda, MD 20892 USA. [Jindal, Rahul M.] Brookdale Univ, Dept Surg, Med Ctr, Brooklyn, NY USA. RP Hurst, FP (reprint author), Walter Reed Army Med Ctr, Dept Med Nephrol, Serv Nephrol, 6900 Georgia Ave NW, Washington, DC 20037 USA. EM frank.hurst@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 24 TC 19 Z9 19 U1 0 U2 1 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 2010 VL 21 IS 9 BP 1571 EP 1577 DI 10.1681/ASN.2010010025 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 669JZ UT WOS:000283345000024 PM 20705713 ER PT J AU Watson, S AF Watson, Samuel TI The Business of Civil War: Military Mobilization and the State, 1861-1865. SO JOURNAL OF THE EARLY REPUBLIC LA English DT Book Review C1 [Watson, Samuel] US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU UNIV PENNSYLVANIA PRESS PI PHILADELPHIA PA JOURNALS DIVISION, 3905 SPRUCE STREET, PHILADELPHIA, PA 19104 USA SN 0275-1275 J9 J EARLY REPUBL JI J. Early Repub. PD FAL PY 2010 VL 30 IS 3 BP 467 EP 477 PG 11 WC History SC History GA V23LM UT WOS:000208344300007 ER PT J AU Watson, S AF Watson, Samuel TI The Railroad and the State: War, Politics, and Technology in Nineteenth-Century America. SO JOURNAL OF THE EARLY REPUBLIC LA English DT Book Review C1 [Watson, Samuel] US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU UNIV PENNSYLVANIA PRESS PI PHILADELPHIA PA JOURNALS DIVISION, 3905 SPRUCE STREET, PHILADELPHIA, PA 19104 USA SN 0275-1275 J9 J EARLY REPUBL JI J. Early Repub. PD FAL PY 2010 VL 30 IS 3 BP 467 EP 477 PG 11 WC History SC History GA V23LM UT WOS:000208344300005 ER PT J AU Watson, S AF Watson, Samuel TI Nations, Markets, and War: Modern History and the American Civil War. SO JOURNAL OF THE EARLY REPUBLIC LA English DT Book Review C1 [Watson, Samuel] US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV PENNSYLVANIA PRESS PI PHILADELPHIA PA JOURNALS DIVISION, 3905 SPRUCE STREET, PHILADELPHIA, PA 19104 USA SN 0275-1275 J9 J EARLY REPUBL JI J. Early Repub. PD FAL PY 2010 VL 30 IS 3 BP 467 EP 477 PG 11 WC History SC History GA V23LM UT WOS:000208344300006 ER PT J AU Abouassaly, CT Dutton, WD Zaydfudim, V Dossett, LA Nunez, TC Fleming, SB Cotton, BA AF Abouassaly, Chadi T. Dutton, William D. Zaydfudim, Victor Dossett, Lesly A. Nunez, Timothy C. Fleming, Sloan B. Cotton, Bryan A. TI Postoperative Neuromuscular Blocker Use Is Associated With Higher Primary Fascial Closure Rates After Damage Control Laparotomy SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Neuromuscular blocker; Neuromuscular blockade; Fascial closure; Damage control laparotomy ID ABDOMINAL COMPARTMENT SYNDROME; PLANNED VENTRAL HERNIA; OPEN ABDOMEN; INTRAABDOMINAL HYPERTENSION; STAGED MANAGEMENT; WALL DEFECTS; TRAUMA; RECONSTRUCTION; DEFINITIONS; EXPERIENCE AB Background: Failure to achieve fascial primary closure after damage control laparotomy (DCL) is associated with increased morbidity, higher healthcare expenditures, and a reduction in quality of life. The use of neuromuscular blocking agents (NMBA) to facilitate closure remains controversial and poorly studied. The purpose of this study was to determine whether exposure to NMBA is associated a higher likelihood of primary fascial closure. Methods: All adult trauma patients admitted between January 2002 and May 2008 who (1) went directly to the operating room, (2) were managed initially by DCL, and (3) survived to undergo a second laparotomy. Study group (NMBA+): those receiving NMBA in the first 24 hours after DCL. Comparison group (NMBA-): those not receiving NMBA in the first 24 hours after DCL. Primary fascial closure defined as fascia-to-fascia approximation by hospital day 7. Results: One hundred ninety-one patients met inclusion (92 in NMBA+ group, 99 in NMBA- group). Although the NMB+ patients were younger (31 years vs. 37 years, p = 0.009), there were no other differences in demographics, severity of injury, or lengths of stay between the groups. However, NMBA+ patients achieved primary closure faster (5.1 days vs. 3.5 days, p = 0.046) and were more likely to achieve closure by day 7 (93% vs. 83%, p = 0.023). After controlling for age, gender, race, mechanism, and severity of injury, logistic regression identified NMBA use as an independent predictor of achieving primary fascial closure by day 7 (OR, 3.24, CI: 1.15-9.16; p = 0.026). Conclusions: Early NMBA use is associated with faster and more frequent achievement of primary fascial closure in patients initially managed with DCL. Patients exposed to NMBA had a three times higher likelihood of achieving primary fascial closure by hospital day 7. C1 [Abouassaly, Chadi T.; Dutton, William D.; Zaydfudim, Victor; Dossett, Lesly A.] Vanderbilt Univ, Sch Med, Dept Surg, Nashville, TN 37212 USA. [Nunez, Timothy C.] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA. [Fleming, Sloan B.] Vanderbilt Univ, Sch Med, Dept Clin Pharmacol, Nashville, TN 37212 USA. [Cotton, Bryan A.] Univ Texas Hlth Sci Ctr, Dept Surg, Houston, TX USA. [Cotton, Bryan A.] Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, Houston, TX USA. RP Cotton, BA (reprint author), UTHSCH CeTIR, 6410 Fannin St,1100-20 UPB, Houston, TX 77030 USA. EM bryan.a.cotton@uth.tmc.edu NR 29 TC 12 Z9 12 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 2010 VL 69 IS 3 BP 557 EP 561 DI 10.1097/TA.0b013e3181e77ca4 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 649HX UT WOS:000281760800016 PM 20838126 ER PT J AU McQuade, K Gable, D Pearl, G Theune, B Black, S AF McQuade, Karen Gable, Dennis Pearl, Greg Theune, Brian Black, Steve TI Four-year randomized prospective comparison of percutaneous ePTFE/nitinol self-expanding stent graft versus prosthetic femoral-popliteal bypass in the treatment of superficial femoral artery occlusive disease SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID INTER-SOCIETY CONSENSUS; TRANSLUMINAL ANGIOPLASTY; NITINOL STENTS; LESIONS; ENDOPROSTHESIS; IMPLANTATION; EXPERIENCE; MANAGEMENT; STANDARDS; ISCHEMIA AB Background: This is a randomized prospective study comparing the treatment of superficial femoral artery occlusive disease percutaneously with an expanded polytetrafluoroethylene (ePTFE)/nitinol self-expanding stent graft (stem graft) versus surgical femoral to above-knee pophteal artery bypass with synthetic graft material. Methods: One hundred limbs in 86 patients with superficial femoral artery occlusive disease were evaluated from March 2004 to May 2005..Patient symptoms included both claudication and limb threatening ischemia with or without tissue loss. Trans-Atlantic Inter Society Consensus (rAsc II) A (n = 18), B (n = 56), C (n = 11), and 13 (n = 15) lesions were included. Patients were randomized prospectively into one of two treatment groups; a percutaneous treatment group (group A; n = 50) with angioplasty and placement of one or more stent grafts, or a surgical treatment group (group B; n = 50) with a femoral to above-knee pophteal artery bypass using synthetic conduit (Dacron or ePTFE). Patients were followed for 48 months. Follow-up evaluation included clinical assessment, physical examination, ankle-brachial Indices, and color flow duplex sonography at 3, 6, 9, 12, 18, 24, 36, and 48 months. Results: Mean total lesion length of the treated arterial segment in the stein graft group was 25.6 cm (SD = 15 cm). The stent graft group demonstrated a primary patency of 72%, 63%, 63%, and 59% with a secondary patency of 83%, 74%, 74%, and 74% at 12, 24, 36, and 48 months, respectively. The surgical femoral-popliteal group demonstrated a primary patency of 76%, 63%, 63%, and 58% with a secondary pateney of 86%, 76%, 76%, and 71% at 12, 24, 36, and 48 months, respectively. No statistical difference was found between the two groups with respect to primary (P =.807) or secondary (P =.891) patency. Conclusion: Management of superficial femoral artery occlusive disease with percutaneous stent grafts exhibits similar primary patency at 4-year (48 month) follow up when compared with conventional femoral-popliteal artery bypass grafting with synthetic conduit. This treatment method may offer an alternative to treatment of the superficial femoral artery segment for revascularization when prosthetic bypass is being considered or when autologous conduit is unavailable. (J Vase Surg 2010;52:584-91.) C1 [McQuade, Karen; Gable, Dennis; Pearl, Greg; Black, Steve] Baylor Univ, Med Ctr, Dept Vasc Surg, Dallas, TX 75226 USA. [Theune, Brian] Womack Army Med Ctr, Dept Vasc Surg, Ft Bragg, NC USA. RP Gable, D (reprint author), Baylor Univ, Med Ctr, Dept Gen & Vasc Surg, 621 N Hall St,Ste 100, Dallas, TX 75226 USA. NR 37 TC 55 Z9 60 U1 1 U2 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD SEP PY 2010 VL 52 IS 3 BP 584 EP 591 DI 10.1016/j.jvs.2010.03.071 PG 8 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 646VB UT WOS:000281570100008 PM 20598480 ER PT J AU Kobayashi, N Farhadzadeh, A Melby, JA AF Kobayashi, Nobuhisa Farhadzadeh, Ali Melby, Jeffrey A. TI Wave Overtopping and Damage Progression of Stone Armor Layer SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE Wave overtopping; Rubble mounds; Permeability; Damage progression; Probability; Numerical model ID RUBBLE-MOUND BREAKWATERS; PERMEABLE SLOPES AB A probabilistic hydrodynamic model for the wet and dry zone on a permeable structure is developed to predict irregular wave action on the structure above the still water level. The model is based on the time-averaged continuity and momentum equations for nonlinear shallow-water waves coupled with the exponential probability distribution of the water depth. The model predicts the cross-shore variations of the mean and standard deviation of the water depth and horizontal velocity. The model is compared with four test series in which measurement was made of the wave overtopping rate and probability as well as the water depth, velocity, and discharge exceeded by 2% of incident 1,000 waves. The agreement is mostly within a factor of 2. Damage progression of a stone armor layer is predicted by modifying a formula for bed load on beaches with input from the hydrodynamic model. The damage progression model is compared with three tests that lasted up to 28.5 h. The model predicts the eroded area of the damaged armor layer well but overpredicts the deposited area because it does not account for discrete stone units deposited at a distance seaward of the toe of the damaged armor layer. C1 [Kobayashi, Nobuhisa] Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. [Melby, Jeffrey A.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Farhadzadeh, Ali] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. RP Kobayashi, N (reprint author), Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. FU U.S. Army Corps of Engineers, Coastal and Hydraulics Laboratory [W912HZ-08-P-0342, W912BU-09-C-0023]; Office, Chief of Engineers, U.S. Army Corps of Engineers FX This study was supported by the U.S. Army Corps of Engineers, Coastal and Hydraulics Laboratory under Contract Nos. W912HZ-08-P-0342 and W912BU-09-C-0023. Permission to publish this paper was granted by the Office, Chief of Engineers, U.S. Army Corps of Engineers. NR 18 TC 5 Z9 5 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD SEP-OCT PY 2010 VL 136 IS 5 BP 257 EP 265 DI 10.1061/(ASCE)WW.1943-5460.0000047 PG 9 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 639EI UT WOS:000280953200002 ER PT J AU Kim, HC Lee, IY Chong, ST Richards, AL Gu, SH Song, JW Lee, JS Klein, TA AF Kim, Heung Chul Lee, In Yong Chong, Sung Tae Richards, Allen L. Gu, Se Hun Song, Jin-Won Lee, John S. Klein, Terry A. TI Serosurveillance of Scrub Typhus in Small Mammals Collected from Military Training Sites near the DMZ, Northern Gyeonggi-do, Korea, and Analysis of the Relative Abundance of Chiggers from Mammals Examined SO KOREAN JOURNAL OF PARASITOLOGY LA English DT Article DE Apodemus agrarius; Mus musculus; Crocidura lasiura; chigger; Leptotrombidium; scrub typhus ID REPUBLIC-OF-KOREA; FIRING POINTS 10; GEOGRAPHICAL-DISTRIBUTION; SEROLOGICAL SURVEILLANCE; MURINE TYPHUS; LEPTOSPIROSIS; PROVINCE; TSUTSUGAMUSHI AB Comprehensive quarterly serosurveillance on scrub typhus in small mammals collected from military training sites located near the Demilitarized Zone (DMZ), northern Gyeonggi-do (Province), ROK was conducted to determine the potential rodent-borne and associated ectoparasite disease risks to military personnel. A total of 1,196 rodents and insectivores representing 8 species, Apodemus agrarius (87.3%, n = 1,044), Mus musculus (5.4%, n = 65), Crocidura lasiura (3.3%, n = 40), Microtus fortis (2.6%, n = 31), Micromys minutus (0.3%, n = 4), Tscherskia triton (0.3%, n = 4), Rattus norvegicus (0.3%, n = 4), and Myodes regulus (0.3%, n = 4) were assayed for the presence of antibodies to Orientia tsutsugamushi. O. tsutsugamushi antibodies were detected in 6 of 8 species and seroprevalence determined; A. agrarius (45.6%), M. musculus (23.1%), M. fortis (48.4%), M. minutus (50.0%), T. triton (50.0%), and R. norvegicus (25.0%). A total of 31,184 chigger mites collected from 508 rodents and insectivores were slide-mounted and 10 species belonging to 4 genera were identified. Leptotrombidium pallidum (53.4%) was the most frequently collected, followed by L. palpale (15.7%), Neotrombicula tamiyai (14.3%), L. orientale (10.7%), L. zetum (3.1%), Walchia fragilis (2.1%), and L. gemiticulum (0.8%), while the remaining 3 species, L. subintermedium, N. gardellai, and Euschoengastia koreaensis were rarely observed (prevalence < 10%). In contrast to previous surveys, higher chigger indices of the primary scrub typhus vectors, L. pallidum (165.4), L. orientale (45.0), and L. palpale (21.4), were observed during the spring season. C1 [Lee, In Yong] Yonsei Univ, Dept Environm Med Biol, Coll Med, Seoul 120752, South Korea. [Kim, Heung Chul; Chong, Sung Tae] 168th Multifunct Med Detachment, Med Detachment 5, Med Brigade 65, Unit 15247, APO, AP 96205 USA. [Richards, Allen L.] USN, Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. [Gu, Se Hun; Song, Jin-Won] Korea Univ, Coll Med, Dept Microbiol, Seoul 136705, South Korea. [Lee, John S.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Klein, Terry A.] USAMEDDAC Korea, Med Brigade 65, Unit 15281, APO, AP 96205 USA. RP Lee, IY (reprint author), Yonsei Univ, Dept Environm Med Biol, Coll Med, Seoul 120752, South Korea. EM iylee02@yuhs.ac RI Valle, Ruben/A-7512-2013 FU Armed Forces Health Surveillance Center; Global Emerging Infections Surveillance and Response System, Silver Spring, MD; National Center for Medical Intelligence, Ft Detrick, MD FX We thank members of 5th and 38th Medical Detachment for conducting small mammal collections as part of the rodent-borne disease surveillance program of 65th Medical Brigade. We also appreciate the support from Dr. Glen Livet that he provided during this study. Funding for the portion of this work was provided by the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System, Silver Spring, MD, and the National Center for Medical Intelligence, Ft Detrick, MD. NR 30 TC 12 Z9 12 U1 0 U2 6 PU KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI PI SEOUL PA DEPT PARASITOLOGY, SEOUL, 00000, SOUTH KOREA SN 0023-4001 J9 KOREAN J PARASITOL JI Korean J. Parasitol. PD SEP PY 2010 VL 48 IS 3 BP 237 EP 243 DI 10.3347/kjp.2010.48.3.237 PG 7 WC Parasitology SC Parasitology GA 662AQ UT WOS:000282778700007 PM 20877503 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Cultures of War: Pearl Harbor/Hiroshima/9-11/Iraq SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 1 PY 2010 VL 135 IS 14 BP 119 EP 119 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 645YR UT WOS:000281502600118 ER PT J AU Terrill, WA AF Terrill, W. Andrew TI Hussein and Abdullah: Inside the Jordanian Royal Family SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Terrill, W. Andrew] USA, War Coll, Carlisle, PA USA. RP Terrill, WA (reprint author), USA, War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD FAL PY 2010 VL 64 IS 4 BP 666 EP 669 PG 4 WC Area Studies SC Area Studies GA 686EB UT WOS:000284678500022 ER PT J AU Welton, MC AF Welton, Mark C. TI Genocide in the Middle East: The Ottoman Empire, Iraq, and Sudan SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Welton, Mark C.] US Mil Acad, West Point, NY 10996 USA. RP Welton, MC (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD FAL PY 2010 VL 64 IS 4 BP 674 EP 675 PG 2 WC Area Studies SC Area Studies GA 686EB UT WOS:000284678500026 ER PT J AU Duggan, JP AF Duggan, Jerome P. TI THE GAMBLE: GENERAL DAVID PETRAEUS AND THE AMERICAN MILITARY ADVENTURE IN IRAQ, 2006-2008 SO MILITARY LAW REVIEW LA English DT Book Review C1 [Duggan, Jerome P.] USA, Ft Leonard Wood, MI USA. RP Duggan, JP (reprint author), Judge Advocate Generals Legal Ctr & Sch, Ctr Law & Mil Operat, Charlottesville, VA 22903 USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2010 VL 205 BP 229 EP 235 PG 7 WC Law SC Government & Law GA 736TV UT WOS:000288518800008 ER PT J AU Morris, DL AF Morris, Danisha L. TI OUTLIERS: THE STORY OF SUCCESS SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. RP Morris, DL (reprint author), USA, Judge Advocate Officer Grad Course 58, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. NR 11 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2010 VL 205 BP 236 EP 242 PG 7 WC Law SC Government & Law GA 736TV UT WOS:000288518800009 ER PT J AU Bolesh, DT AF Bolesh, David T. TI RE: Methicillin-Resistant Staphylococcus aureus Infections in US Service Members Deployed to Iraq, published in [Mil Med 2009; 174(4): 408-11] SO MILITARY MEDICINE LA English DT Letter C1 [Bolesh, David T.] Kenner Army Hlth Clin, Ft Lee, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2010 VL 175 IS 9 BP X EP XI PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 649QH UT WOS:000281787200004 PM 20882916 ER PT J AU Blanck, RR AF Blanck, Ronald R. TI RE: Editorial, The Uncertain State of US Interrogation Techniques, published in [Mil Med 2009; 174(4): xii-xiv] SO MILITARY MEDICINE LA English DT Letter C1 [Blanck, Ronald R.] USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2010 VL 175 IS 9 BP XII EP XII PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 649QH UT WOS:000281787200006 PM 20882918 ER PT J AU Allison-Aipa, TS Ritter, C Sikes, P Ball, S AF Allison-Aipa, Timothy S. Ritter, Corinne Sikes, Page Ball, Stephanie TI The Impact of Deployment on the Psychological Health Status, Level of Alcohol Consumption, and Use of Psychological Health Resources of Postdeployed US Army Reserve Soldiers SO MILITARY MEDICINE LA English DT Article ID IRAQ AB This study was conducted to investigate the impact of deployment on the psychological health status, level of alcohol consumption, and use of psychological health resources of postdeployed Army Reserve (AR) soldiers. Data were collected from 51,078 postdeployed AR soldiers via DD Form 2900 to detect existing psychological and medical issues. As predicted, findings indicate that AR soldiers screened 7 or more months post redeployment are significantly more likely than those screened 3 to 6 months post redeployment to screen positive for moderate (chi(2) (1, N = 44,319) = 15.75, p < 0.001) and severe (chi(2) (1, N = 44,319) = 7.82, p < 0.05) functional impairment and PTSD (chi(2) (1, N = 51,017) = 14.43, p < 0.001). Present findings are consistent with previous research, suggesting that adverse psychological health issues can be detected during their mild stages and resolved to prevent further degradation when screenings are performed according to military policy. C1 [Allison-Aipa, Timothy S.] Command Surg Off, Moffett Field, CA 94035 USA. [Ritter, Corinne; Sikes, Page; Ball, Stephanie] Army Reserve SurgeonFwd, Off Chief, Arlington, VA 22202 USA. RP Allison-Aipa, TS (reprint author), Command Surg Off, 153 Dailey Rd, Moffett Field, CA 94035 USA. FU AR PDHRA Program FX We are grateful for the support of our research by our AR PDHRA Program colleagues: MAJ Faith Agullana-O'Day, MAJ Stephanie Ball, LTC Charlie Bates, SSG Adalberto Bonilla, SSG Marion Cavanaugh. ILT Jermaine Denny, Mr. Terry Eckhart, MAJ Teresa Funderburg, CPT Rebecca Guerich, MSG Lisa Howard, MSG Sara Meltzer, LTC Linda Moore, SFC Heather Moran, Mr. Erik Noel, CPT Christine Ocasio, MSG Michael Orticari, MM Lorri McLaughlin, SGM Wanda Rich-Morrison, SFC Tina Romero. SEC Marsha Ruskin, MAJ Shana Spears, MAJ Wendell Taylor, CPT Tara Vaughn, SFC Diane Vredeveld, MAJ Kathryn Wickman. and SFC Cathy Woodruff. Funding has been provided for this study by the Office of the Chief, Army Reserve Surgeon-Fwd 1421 Jefferson Davis Hwy Arlington, VA 22202. NR 8 TC 7 Z9 7 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2010 VL 175 IS 9 BP 630 EP 637 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 649QH UT WOS:000281787200017 PM 20882924 ER PT J AU Gonzalez, MN DiFurio, MJ Sundborg, MJ Leath, CA AF Gonzalez, Michelle N. DiFurio, Megan J. Sundborg, Michael J. Leath, Charles A., III TI Undifferentiated Uterine Sarcoma Presenting as a Pathologic Humerus Fracture SO MILITARY MEDICINE LA English DT Article ID ENDOMETRIAL STROMAL SARCOMA AB Background: Undifferentiated uterine sarcomas are rare malignancies often presenting at advanced stage. Case: A female in her ninth decade presented to our MEDCEN emergency department complaining of onset of severe right arm pain while performing activities of daily living. A pathologic humeral fracture was diagnosed and subsequent orthopedic evaluation resulted in a biopsy and placement of her arm in a cooptation splint and sling. An abdominal exam revealed a 10-cm mass in the right lower quadrant that was thought to originate from the uterus. Computed tomography imaging was concerning for a primary endometrial process and she was referred to gynecologic oncology. Her humeral biopsy was consistent with a poorly differentiated metastatic sarcoma. An endometrial biopsy was consistent with undifferentiated uterine sarcoma, the origin of her humeral lesion. Conclusion: Humeral metastasis is an uncommon presentation for undifferentiated endometrial sarcomas. C1 [Gonzalez, Michelle N.; DiFurio, Megan J.; Sundborg, Michael J.; Leath, Charles A., III] Brooke Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Ft Sam Houston, TX 78234 USA. RP Gonzalez, MN (reprint author), Brooke Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. OI Leath III, Charles/0000-0002-4034-6845 NR 5 TC 1 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2010 VL 175 IS 9 BP 691 EP 692 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 649QH UT WOS:000281787200027 PM 20882934 ER PT J AU Beltran, MJ Kirk, KL Hsu, JR AF Beltran, Michael J. Kirk, Kevin L. Hsu, Joseph R. CA Skeletal Trauma Res Consortium STR TI Minimally Invasive Shortening Humeral Osteotomy to Salvage a Through-Elbow Amputation SO MILITARY MEDICINE LA English DT Article AB Objective: Determine the efficacy of a novel surgical technique to salvage a through-elbow amputation and avoid revision transhumeral amputation. Methods: A 23-year-old soldier presented after sustaining a through-elbow amputation in a close-range blast injury with inadequate soft tissues to obtain closure over the distal humerus. A 2-cm anterior incision was made and a shortening osteotomy with percutaneous submuscular osteosynthesis was done. A myodesis was performed and a tension-free primary closure of the soft tissue envelope obtained. Results: At 3 months postoperatively the osteotomy and soft tissue envelope were healed. At 2-year follow-up the patient reports using a body-powered prosthesis for ADLs and recreational hobbies, citing excellent rotational control and ease of prosthetic suspension. Conclusion: Minimally invasive shortening humeral osteotomy in the setting of a through-elbow amputation is a safe and effective procedure, which allows primary soft tissue closure, prevents the need for more proximal amputation, and allows for ease of prosthetic fitting and suspension. C1 [Beltran, Michael J.; Kirk, Kevin L.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Beltran, MJ (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. FU United States Army Institute of Surgical Research, Fort Sam Houston, TX FX Funding for the preparation and presentation of this work was provided by the United States Army Institute of Surgical Research, Fort Sam Houston, TX, 78234. NR 9 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2010 VL 175 IS 9 BP 693 EP 696 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 649QH UT WOS:000281787200028 PM 20882935 ER PT J AU Champagne, VK Helfritch, DJ Trexler, MD Gabriel, BM AF Champagne, Victor K. Helfritch, Dennis J. Trexler, Matthew D. Gabriel, Brian M. TI The effect of cold spray impact velocity on deposit hardness SO MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING LA English DT Article ID COATINGS; INDENTATION AB The deposition and consolidation of metal powders by means of cold spray is a method where powder particles are accelerated to high velocity through entrainment in a gas undergoing expansion in a de Laval nozzle and are subsequently impacted upon a surface. The impacted powder particles form a consolidated structure which can be several centimeters thick. The characteristics of this structure depend on the initial characteristics of the metal powder and upon impact velocity. Initially soft particles are strain hardened during impact, resulting in a structure that can have a hardness value greater than that which can be achieved by conventional cold working. A materials model is proposed for these phenomena, and model calculation is compared with experimental data from cold sprayed copper and aluminum. C1 [Champagne, Victor K.; Helfritch, Dennis J.; Trexler, Matthew D.; Gabriel, Brian M.] USA, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. RP Champagne, VK (reprint author), USA, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. EM vchampag@arl.army.mil NR 12 TC 3 Z9 3 U1 4 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0965-0393 J9 MODEL SIMUL MATER SC JI Model. Simul. Mater. Sci. Eng. PD SEP PY 2010 VL 18 IS 6 AR 065011 DI 10.1088/0965-0393/18/6/065011 PG 8 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 635IN UT WOS:000280648900011 ER PT J AU Bartolucci, SF Zhang, W Warrender, J Lee, S AF Bartolucci, S. F. Zhang, W. Warrender, J. Lee, S. TI Structure and Morphology of Carbon Nanofiber-Polycarbosilane Precursor Derived Nanocomposites SO NANOSCIENCE AND NANOTECHNOLOGY LETTERS LA English DT Article DE Nanotube; Silicon Carbide; Pre-Ceramic Polymer; Nano-Composites; Laser Pulse Heating ID SILICON-CARBIDE; COMPOSITES; NANOTUBES; AMORPHIZATION; OXIDATION; POLYMER AB Carbon nanofibers have been mixed with a liquid silicon carbide precursor material, polycarbosilane, to produce unique structures with a high weight fraction of nanofibers. The liquid precursor and carbon nanofiber fillers were mixed and then compacted together followed by an 850 degrees C heat treatment to crosslink and pyrolyze the precursor polymer/carbon nanofiber mixture into silicon carbide/carbon nanofiber nanocomposites. Electron microscopy and energy dispersive spectroscopy performed on the nanocomposites samples suggest good interfacial bonding between the amorphous silicon carbide and nanofiber. A thin coating of silicon carbide is formed on the carbon nanofiber surface and this coating is oxidized into silicon oxide particles that decorate the nanofibers when exposed to high transient heating by a laser pulse. Nanofibers with well adhered silicon carbide on the surfaces could lead to composites with good interfacial properties. C1 [Bartolucci, S. F.; Warrender, J.; Lee, S.] USA, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. [Zhang, W.] GE Global Res Ctr, Niskayuna, NY 12309 USA. RP Bartolucci, SF (reprint author), USA, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. FU US Army FX This work was supported by US Army In-house Laboratory Independent Research funding. NR 19 TC 2 Z9 2 U1 1 U2 9 PU AMER SCIENTIFIC PUBLISHERS PI VALENCIA PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA SN 1941-4900 J9 NANOSCI NANOTECH LET JI Nanosci. Nanotechnol. Lett. PD SEP PY 2010 VL 2 IS 3 BP 235 EP 239 DI 10.1166/nnl.2010.1086 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 798MI UT WOS:000293211000008 ER PT J AU Warren, TK Warfield, KL Wells, J Swenson, DL Donner, KS Van Tongeren, SA Garza, NL Dong, LA Mourich, DV Crumley, S Nichols, DK Iversen, PL Bavari, S AF Warren, Travis K. Warfield, Kelly L. Wells, Jay Swenson, Dana L. Donner, Kelly S. Van Tongeren, Sean A. Garza, Nicole L. Dong, Lian Mourich, Dan V. Crumley, Stacy Nichols, Donald K. Iversen, Patrick L. Bavari, Sina TI Advanced antisense therapies for postexposure protection against lethal filovirus infections SO NATURE MEDICINE LA English DT Article ID EBOLA HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; VIRUS INFECTION; MARBURG VIRUSES; MOUSE MODEL; GUINEA-PIGS; PATHOGENESIS; EFFICACY; MONKEYS AB Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show that administration of positively charged phosphorodiamidate morpholino oligomers (PMOplus), delivered by various dosing strategies initiated 30-60 min after infection, protects >60% of rhesus monkeys against lethal Zaire Ebola virus (ZEBOV) and 100% of cynomolgus monkeys against Lake Victoria Marburg virus (MARV) infection. PMOplus may be useful for treating these and other highly pathogenic viruses in humans. C1 [Warren, Travis K.; Warfield, Kelly L.; Wells, Jay; Swenson, Dana L.; Donner, Kelly S.; Van Tongeren, Sean A.; Garza, Nicole L.; Dong, Lian; Nichols, Donald K.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Mourich, Dan V.; Crumley, Stacy; Iversen, Patrick L.] AVI Biopharma, Corvallis, OR USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM piversen@avibio.com; sina.bavari@amedd.army.mil FU US Defense Threat Reduction Agency [HDTRA1-07-C-010, 4.10022-08-RD-B, TMTI0048-09-RD-T] FX We thank C. Rice, D. Reed, N. Posten and J. Stockman for technical assistance and M. Ait Ichou and J. Hardick for their help in the initial viral quantification studies. S. Norris and D. Fisher provided statistical assistance and conducted animal randomization procedures. L. Welch, S. Bradfute, R. Panchal and J. Kuhn provided support and discussions and critically reviewed the manuscript. These studies were supported by the US Defense Threat Reduction Agency awarded to AVI BioPharma (HDTRA1-07-C-010) and S. B. (4.10022-08-RD-B and TMTI0048-09-RD-T). NR 20 TC 117 Z9 125 U1 0 U2 8 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 J9 NAT MED JI Nat. Med. PD SEP PY 2010 VL 16 IS 9 BP 991 EP 994 DI 10.1038/nm.2202 PG 4 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA 647MP UT WOS:000281622900026 PM 20729866 ER PT J AU Weeks, SR Anderson-Barnes, VC Tsao, JW AF Weeks, Sharon R. Anderson-Barnes, Victoria C. Tsao, Jack W. TI Phantom Limb Pain Theories and Therapies SO NEUROLOGIST LA English DT Review DE phantom limb pain; amputation; rehabilitation; military medicine; mirror therapy ID ELECTRICAL NERVE-STIMULATION; MASSIVE CORTICAL REORGANIZATION; RECEPTOR ANTAGONIST MEMANTINE; DORSAL COLUMN STIMULATION; PLACEBO-CONTROLLED TRIAL; SPINAL-CORD STIMULATION; POSTAMPUTATION PAIN; NEUROPATHIC PAIN; DOUBLE-BLIND; BODY SCHEMA AB Background and Objective: Since the beginning of the conflicts in Iraq and Afghanistan, there has been a dramatic increase in the number of military service members with single and multiple-limb amputations. Phantom limb pain (PLP) frequently develops in these individuals. As a result, identifying the best methods to treat PLP is critical. The review highlights areas of inquiry related to phantom pain, with a focus on PLP. Review Summary: This review discusses phantom sensations and phantom pain that arise after amputation of a body part, and summarizes the differences between the 2 conditions. Characteristics of PLP are also discussed, including the onset, duration, and location of PLP. Theories explaining the etiology and presence of PLP are reviewed, along with the numerous treatment options reported in the published data for such pain, including the use of mirrors for treating pain. We conclude with a description of one military hospital's experiences with PLP. Conclusions: Although more research has been done in previous years, this review identifies the need for continuing investigations. The etiology of PLP needs to be determined through more vigorous investigation, and a focus must be placed on defining treatment options in addition to mirror therapy that will improve the quality of life of those who suffer from this condition. C1 [Tsao, Jack W.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Weeks, Sharon R.; Anderson-Barnes, Victoria C.] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. RP Tsao, JW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, 4301 Jones Bridge Rd,Room A1036, Bethesda, MD 20814 USA. EM jtsao@usuhs.mil OI Weeks, Sharon/0000-0002-9952-9136 FU Military Amputee Research Program; Dana Foundation FX Supported by the Military Amputee Research Program and the Dana Foundation. NR 121 TC 46 Z9 52 U1 8 U2 51 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1074-7931 J9 NEUROLOGIST JI Neurologist PD SEP PY 2010 VL 16 IS 5 BP 277 EP 286 DI 10.1097/NRL.0b013e3181edf128 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA 647IX UT WOS:000281613100001 PM 20827116 ER PT J AU Apland, JP Figueiredo, TH Qashu, F Aroniadou-Anderjaska, V Souza, AP Braga, MFM AF Apland, James P. Figueiredo, Taiza H. Qashu, Felicia Aroniadou-Anderjaska, Vassiliki Souza, Adriana P. Braga, Maria F. M. TI Higher susceptibility of the ventral versus the dorsal hippocampus and the posteroventral versus anterodorsal amygdala to soman-induced neuropathology SO NEUROTOXICOLOGY LA English DT Article DE Hippocampus; Amygdala; Soman; Neuronal degeneration; Nerve agents; Status epilepticus ID TEMPORAL-LOBE EPILEPSY; STATUS EPILEPTICUS; INDUCED SEIZURES; NERVE AGENTS; INDUCED CONVULSIONS; RATS; DIAZEPAM; SURVIVAL; COMPLEX; LESIONS AB Nerve agents are acetylcholinesterase inhibitors, exposure to which causes brain damage, primarily by inducing intense seizure activity. Knowledge of the brain regions that are most vulnerable to nerve agent-induced brain damage can facilitate the development of drugs targeting the protection of these regions. Both the amygdala and the hippocampus have been shown to suffer significant damage after nerve agent exposure, but the amygdala appears to be the more severely affected structure. However, damage in the amygdala has generally been compared with damage in the dorsal hippocampus, whereas there is evidence that the ventral hippocampus is significantly more susceptible to seizures than the dorsal region and, therefore, it may also be more susceptible to nerve agent-induced neuropathology. Here, we report that after status epilepticus induced by soman administration to rats, neuronal degeneration as assessed by Fluoro-Jade C staining was more extensive in the ventral than the dorsal hippocampal subfields, 1 day after soman exposure. Seven days later, the difference between dorsal and ventral regions was not statistically significant. In the amygdala, soman-induced neurodegeneration was more severe in the posteroventral regions of the lateral, basolateral, and medial nuclei compared to the anterodorsal regions of these nuclei. In contrast, the basomedial nucleus was more severely affected in the anterodorsal region. The extent of neurodegeneration in the amygdala was not significantly different from that in the ventral hippocampus. However, when compared with the whole hippocampus, the amygdala displayed more severe neurodegeneration, on both day 1 and day 7 after soman exposure. Testing the protective efficacy of drugs against nerve agent-induced brain damage should include examination of the ventral hippocampus and the posteroventral regions of the amygdala, as these areas are most vulnerable to nerve agent-induced neurodegeneration. Published by Elsevier Inc. C1 [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Dept Psychiat, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Apland, James P.] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Dept Psychiat, F Edward Hebert Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM mbraga@usuhs.mil FU National Institutes of Health through National Institute of Neurological Disorders and Stroke [U01 N5058162-01]; Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [1.E0021_07_US_C] FX This work was supported by the National Institutes of Health CounterACT Program through the National Institute of Neurological Disorders and Stroke (award # U01 N5058162-01), and the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division, grant # 1.E0021_07_US_C. NR 41 TC 23 Z9 23 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD SEP PY 2010 VL 31 IS 5 BP 485 EP 492 DI 10.1016/j.neuro.2010.05.014 PG 8 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 651PI UT WOS:000281939200010 PM 20570628 ER PT J AU Lahti, J AF Lahti, Janne TI Journey to the "Outside" THE US ARMY ON THE ROAD TO THE SOUTHWEST SO NEW MEXICO HISTORICAL REVIEW LA English DT Article RP Lahti, J (reprint author), USA, Washington, DC USA. NR 66 TC 0 Z9 0 U1 0 U2 0 PU UNIV NEW MEXICO PI ALBUQUERQUE PA NEW MEXICO HISTORICAL REVIEW, 1013 MESA VISTA HALL, ALBUQUERQUE, NM 87131-1186 USA SN 0028-6206 J9 NEW MEX HIST REV JI N. M. Hist. Rev. PD FAL PY 2010 VL 85 IS 4 BP 349 EP 374 PG 26 WC History SC History GA 680SU UT WOS:000284255500002 ER PT J AU Spies, JB Bradley, LD Guido, R Maxwell, GL Levine, BA Coyne, K AF Spies, James B. Bradley, Linda D. Guido, Richard Maxwell, G. Larry Levine, Betty A. Coyne, Karin TI Outcomes From Leiomyoma Therapies Comparison With Normal Controls SO OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT Annual Scientific Meeting of the Society-of-Interventional-Radiology CY MAR 14, 2010 CL Tampa, FL SP Soc Intervent Radiol ID QUALITY-OF-LIFE; UTERINE-ARTERY EMBOLIZATION; MENSTRUAL BLOOD-LOSS; RANDOMIZED-TRIAL; FIBROID REGISTRY; UNITED-STATES; HYSTERECTOMY; MENORRHAGIA; SURGERY; SYMPTOMS AB OBJECTIVE: To assess the severity of symptoms caused by uterine leiomyomas, their effect on health-related quality of life, and the change after treatment compared with a normal control group. METHODS: A multicenter nonrandomized prospective study was completed assessing 12-month outcomes from three leiomyoma treatments. Outcome measures included the Uterine Fibroid Symptom and Quality of Life and the Short Form 36 questionnaires. Women scheduled for hysterectomy, myomectomy, or uterine artery embolization were recruited, as well as normal control group members. Questionnaires were completed at baseline and at 6 and 12 months posttreatment. Baseline characteristics were summarized using descriptive statistics. General linear models were used to examine differences among the patient groups. RESULTS: A total of 375 patients completed baseline enrollment: 101 normal, 107 embolization, 61 myomectomy, and 106 hysterectomy. At baseline, the mean Uterine Fibroid Symptom and Quality of Life Symptom Severity score for women in the normal control group was 15.3 (+/- 14.5) and 64.8 (+/- 20) for the leiomyoma patients (P<.001). At 6 and 12 months, the mean Symptom score for women in the normal control group was unchanged, while the leiomyoma treatment group score reduced to a mean of 17.8 (+/- 17.5) at 12 months. Similar magnitude changes occurred among the Uterine Fibroid Symptom and Quality of Life health-related quality of life subscale scores for the normal control group members and leiomyoma patients. At 12 months, the hysterectomy group reported significantly lower symptoms and better health-related quality of life than the other two therapies (P<.001). CONCLUSION: At 12 months after treatment, all three leiomyoma therapies resulted in substantial symptom relief, to near normal levels, with the greatest improvement after hysterectomy. C1 [Spies, James B.] Georgetown Univ Hosp, Dept Radiol, Washington, DC 20007 USA. Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA. Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA. Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. United BioSource Inc, Bethesda, MD USA. RP Spies, JB (reprint author), Georgetown Univ Hosp, Dept Radiol, CG201,3800 Reservoir Rd NW, Washington, DC 20007 USA. EM spiesj@gunet.georgetown.edu NR 17 TC 37 Z9 40 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD SEP PY 2010 VL 116 IS 3 BP 641 EP 652 DI 10.1097/AOG.0b013e3181ed36b3 PG 12 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 642AY UT WOS:000281176400013 PM 20733447 ER PT J AU Salinas, NL Barrera, JE AF Salinas, Nathan L. Barrera, Jose E. TI Coblation lesion formation in a porcine tongue model SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID VOLUMETRIC TISSUE REDUCTION; RADIOFREQUENCY ABLATION; SURGERY; BASE AB OBJECTIVE: To investigate, in a porcine tongue model, the lesions created by coblation to define the optimal application of this method in treating the enlarged tongue base in patients with obstructive sleep apnea syndrome. STUDY DESIGN: A prospective, experimental animal study. SETTING: Military medical center. SUBJECTS AND METHODS: Fifteen fresh porcine tongue specimens were injected with normal saline, and a single coblation probe was applied to the tongue specimens to create multiple submucosal lesions at specific energy settings. Control lesions were created without the use of saline injections. After creating the lesions, the porcine tongue specimens were sectioned and examined grossly. Size and character of lesions were recorded for each of the specimens and were compared across energy settings. RESULTS: The energy applied at each setting was calculated on the basis of watts multiplied by treatment time. Coblation with saline injection created visible lesions with an average lesion area of 1.20 to 2.87 cm(2). The average lesion area increased as setting increased. Without saline injection, the average lesion area was 0.15 to 0.8 cm(2). CONCLUSION: The porcine tongue model describes the relationship between lesion size and cold ablation device settings. Setting, but not time, significantly affects lesion size. The coblation setting and treatment time directly impact the amount of energy delivered. Additionally, submucosal normal saline injection significantly increases lesion size at all settings and application times. Given the average lesion diameter described in this study, placing lesions 1 cm apart will optimize the area affected by coblation while minimizing lesion overlap. (C) 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Salinas, Nathan L.] Brooke Army Med Ctr, Dept Otolaryngol, Ft Sam Houston, TX 78234 USA. [Barrera, Jose E.] Wilford Hall USAF Med Ctr, Dept Otolaryngol, Div Sleep Surg Facial Plast & Reconstruct Surg, Lackland AFB, TX USA. RP Salinas, NL (reprint author), 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM nathan.salinas@us.army.mil FU 59th Medical Wing Clinical Research Division at Lack land Air Force Base FX This study was funded by the 59th Medical Wing Clinical Research Division at Lack land Air Force Base, which provided funding to purchase coblation devices from ArthroCare ENT, Sunnyvale, CA. Devices were used for data collection. NR 15 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD SEP PY 2010 VL 143 IS 3 BP 448 EP 453 DI 10.1016/j.otohns.2010.04.016 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 643OX UT WOS:000281308400024 PM 20723786 ER PT J AU van Kleef, M Vanelderen, P Cohen, SP Lataster, A Van Zundert, J Mekhail, N AF van Kleef, Maarten Vanelderen, Pascal Cohen, Steven P. Lataster, Arno Van Zundert, Jan Mekhail, Nagy TI 12. Pain Originating from the Lumbar Facet Joints SO PAIN PRACTICE LA English DT Article DE evidence-based medicine; low back pain; zygapophysial joint; lumbar facet; radiofrequency treatment ID LOW-BACK-PAIN; NONSURGICAL INTERVENTIONAL THERAPIES; CONTROLLED CLINICAL-TRIAL; CHRONIC SPINAL PAIN; ZYGAPOPHYSIAL JOINT; RADIOFREQUENCY DENERVATION; MEDIAL-BRANCH; COMPUTED-TOMOGRAPHY; DOUBLE-BLIND; PULSED RADIOFREQUENCY AB Although the existence of a "facet syndrome" had long been questioned, it is now generally accepted as a clinical entity. Depending on the diagnostic criteria, the zygapophysial joints account for between 5% and 15% of cases of chronic, axial low back pain. Most commonly, facetogenic pain is the result of repetitive stress and/or cumulative low-level trauma, leading to inflammation and stretching of the joint capsule. The most frequent complaint is axial low back pain with referred pain perceived in the flank, hip, and thigh. No physical examination findings are pathognomonic for diagnosis. The strongest indicator for lumbar facet pain is pain reduction after anesthetic blocks of the rami mediales (medial branches) of the rami dorsales that innervate the facet joints. Because false-positive and, possibly, false-negative results may occur, results must be interpreted carefully. In patients with injection-confirmed zygapophysial joint pain, procedural interventions can be undertaken in the context of a multidisciplinary, multimodal treatment regimen that includes pharmacotherapy, physical therapy and regular exercise, and, if indicated, psychotherapy. Currently, the "gold standard" for treating facetogenic pain is radiofrequency treatment (1 B+). The evidence supporting intra-articular corticosteroids is limited; hence, this should be reserved for those individuals who do not respond to radiofrequency treatment (2 B +/-). C1 [van Kleef, Maarten; Van Zundert, Jan] Univ Med Ctr Maastricht, Dept Anesthesiol & Pain Management, Maastricht, Netherlands. Ziekenhuis Oost Limburg, Ctr Multidisciplinary Pain, Dept Anesthesiol, Genk, Belgium. [Vanelderen, Pascal; Van Zundert, Jan] Radboud Univ Nijmegen, Med Ctr, Dept Pain Management & Palliat Care Med, NL-6525 ED Nijmegen, Netherlands. [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lataster, Arno] Maastricht Univ, Dept Anat & Embryol, NL-6202 AZ Maastricht, Netherlands. [Mekhail, Nagy] Cleveland Clin, Dept Pain Management, Cleveland, OH 44106 USA. RP van Kleef, M (reprint author), Maastricht Univ, Med Ctr, Dept Anesthesiol & Pain Management, POB 5800, NL-6202 AZ Maastricht, Netherlands. EM maarten.van.kleef@mumc.nl NR 91 TC 29 Z9 30 U1 0 U2 10 PU WILEY PERIODICALS, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA SN 1530-7085 J9 PAIN PRACT JI Pain Pract. PD SEP-OCT PY 2010 VL 10 IS 5 BP 459 EP 469 DI 10.1111/j.1533-2500.2010.00393.x PG 11 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 840TH UT WOS:000296463700008 PM 20667027 ER PT J AU Vanelderen, P Szadek, K Cohen, SP De Witte, J Lataster, A Patijn, J Mekhail, N van Kleef, M Van Zundert, J AF Vanelderen, Pascal Szadek, Karolina Cohen, Steven P. De Witte, Jan Lataster, Arno Patijn, Jacob Mekhail, Nagy van Kleef, Maarten Van Zundert, Jan TI 13. Sacroiliac Joint Pain SO PAIN PRACTICE LA English DT Article DE evidence-based medicine; low back pain; sacroiliac joint; radiofrequency; cooled radiofrequency treatment ID LOW-BACK-PAIN; LATERAL BRANCH BLOCKS; PERIARTICULAR CORTICOSTEROID TREATMENT; RADIOFREQUENCY DENERVATION; PROVOCATION TESTS; FOLLOW-UP; INJECTION; SPONDYLARTHROPATHY; ANESTHETIZE; GUIDELINES AB The sacroiliac joint accounts for approximately 16% to 30% of cases of chronic mechanical low back pain. Pain originating in the sacroiliac joint is predominantly perceived in the gluteal region, although pain is often referred into the lower and upper lumbar region, groin, abdomen, and/or lower limb(s). Because sacroiliac joint pain is difficult to distinguish from other forms of low back pain based on history, different provocative maneuvers have been advocated. Individually, they have weak predictive value, but combined batteries of tests can help ascertain a diagnosis. Radiological imaging is important to exclude "red flags" but contributes little in the diagnosis. Diagnostic blocks are the diagnostic gold standard but must be interpreted with caution, because false-positive as well as false-negative results occur frequently. Treatment of sacroiliac joint pain is best performed in the context of a multidisciplinary approach. Conservative treatments address the underlying causes (posture and gait disturbances) and consist of exercise therapy and manipulation. Intra-articular sacroiliac joint infiltrations with local anesthetic and corticosteroids hold the highest evidence rating (1 B+). If the latter fail or produce only short-term effects, cooled radiofrequency treatment of the lateral branches of S1 to S3 (S4) is recommended (2 B+) if available. When this procedure cannot be used, (pulsed) radiofrequency procedures targeted at L5 dorsal ramus and lateral branches of S1 to S3 may be considered (2 C+). C1 [Vanelderen, Pascal; Van Zundert, Jan] Ziekenhuis Oost Limburg, Ctr Multidisciplinary Pain, Dept Anesthesiol, B-3600 Genk, Belgium. [Vanelderen, Pascal] Radboud Univ Nijmegen, Med Ctr, Dept Anesthesiol Pain Therapy & Palliat Care, NL-6525 ED Nijmegen, Netherlands. [Szadek, Karolina] Vrije Univ Amsterdam, Dept Anesthesiol & Pain Management, Amsterdam, Netherlands. [Cohen, Steven P.] Johns Hopkins Med Inst, Dept Anesthesiol, Baltimore, MD 21205 USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [De Witte, Jan] Onze Lieve Vrouw Hosp, Dept Anesthesiol Intens Care Med & Pain Managemen, Aalst, Belgium. [Lataster, Arno] Maastricht Univ, Dept Anat & Embryol, Maastricht, Netherlands. [Patijn, Jacob; van Kleef, Maarten; Van Zundert, Jan] Maastricht Univ, Med Ctr, Dept Anesthesiol & Pain Management, Maastricht, Netherlands. [Mekhail, Nagy] Cleveland Clin, Dept Pain Management, Cleveland, OH 44106 USA. RP Vanelderen, P (reprint author), Ziekenhuis Oost Limburg, Ctr Multidisciplinary Pain, Dept Anesthesiol, Stalenstr 2, B-3600 Genk, Belgium. EM pascal.vanelderen@gmail.com NR 47 TC 28 Z9 29 U1 0 U2 9 PU WILEY PERIODICALS, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA SN 1530-7085 J9 PAIN PRACT JI Pain Pract. PD SEP-OCT PY 2010 VL 10 IS 5 BP 470 EP 478 DI 10.1111/j.1533-2500.2010.00394.x PG 9 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 840TH UT WOS:000296463700009 PM 20667026 ER PT J AU Lumsden, JM Cranmer, MA Krzych, U AF Lumsden, J. M. Cranmer, M. A. Krzych, U. TI An early commitment to expression of a particular TCRV beta chain on CD8+T cells responding to attenuated Plasmodium berghei sporozoites is maintained following challenge with infectious sporozoites SO PARASITE IMMUNOLOGY LA English DT Article DE CD8+T cells; liver stage; malaria; mouse; Plasmodium berghei; TCR V beta repertoire ID CD8(+) T-CELLS; PROTECTIVE IMMUNITY; IRRADIATED SPOROZOITES; MEMORY-PHENOTYPE; CLASS-I; PROTRACTED PROTECTION; CEREBRAL MALARIA; LIVER STAGES; RECEPTOR; REPERTOIRE AB P>Protection induced by irradiated Plasmodium berghei sporozoites (Pb gamma-spz) in mice is linked to CD8+ T cells specific for exo-erythrocytic-stage Ags, and intrahepatic memory CD8+ T cells are associated with protracted protection. However, the Ag specificity of the protective CD8+ T cells remains largely unknown. In this study, we characterized the TCR V beta usage by intrahepatic CD8+ T cells during gamma-spz immunization and after the challenge with infectious Pb sporozoites. The repertoire of naive (T(N)) and central memory (T(CM)) CD8+ T cells was diverse and conserved between individual mice, and did not change with immunization. In contrast, preferential usage of one or more TCR V beta subset was observed in effector memory (T(EM)) CD8+ T cells after immunization. The expanded TCR V beta varied between individual mice but V beta 4, 6, 7, 8.3, 9 and 11 were the most frequently expressed. In addition, there was a correlation in the TCR V beta usage by gamma-spz-induced CD8+ T(EM) in the liver and blood of individual mice. The expansion pattern of blood CD8+ T(EM) did not change with challenge and remained the same for 8 weeks thereafter. These results demonstrate that immunization with gamma-spz skews the TCR V beta repertoire of CD8+ T(EM), and commitment to a particular TCR V beta expression is maintained long-term. C1 [Lumsden, J. M.; Cranmer, M. A.; Krzych, U.] Walter Reed Army Inst Res, Dept Cellular Immunol, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. RP Krzych, U (reprint author), Walter Reed Army Inst Res, Dept Cellular Immunol, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Urszula.Krzych@amedd.army.mil FU NIH [AI46438]; US Army Research and Materiel Command FX This work is supported in part by a grant from the NIH AI46438 (UK) and by US Army Research and Materiel Command. NR 57 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0141-9838 J9 PARASITE IMMUNOL JI Parasite Immunol. PD SEP-OCT PY 2010 VL 32 IS 9-10 BP 644 EP 655 DI 10.1111/j.1365-3024.2010.01220.x PG 12 WC Immunology; Parasitology SC Immunology; Parasitology GA 635RK UT WOS:000280673600002 PM 20691016 ER PT J AU Buates, S Bantuchai, S Sattabongkot, J Han, ET Tsuboi, T Udomsangpetch, R Sirichaisinthop, J Tan-Ariya, P AF Buates, Sureemas Bantuchai, Sirasate Sattabongkot, Jetsumon Han, Eun-Taek Tsuboi, Takafumi Udomsangpetch, Rachanee Sirichaisinthop, Jeeraphat Tan-Ariya, Peerapan TI Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) for clinical detection of Plasmodium falciparum gametocytes SO PARASITOLOGY INTERNATIONAL LA English DT Article DE P. falciparum gametocytes; Reverse transcription-loop-mediated; isothermal amplification (RT-LAMP); Pfs16; Pfs25; Gametocyte detection ID SEQUENCE-BASED AMPLIFICATION; MALARIA PARASITE; ANOPHELES-GAMBIAE; INFECTIVITY; EXPRESSION; MEMBRANE; PFS16; MOSQUITOS; RESERVOIR; SAMPLES AB Plasmodium falciparum gametocytes are usually present in peripheral blood at a very low level, thus requiring a sensitive assay detection method. In this study, reverse transcription-loop-mediated isothermal amplification (RT-LAMP) was developed for clinical detection of P. falciparum gametocytes. Transcripts of Pfs16 of sexually committed ring and Pfs25 of mature gametocytes were detected by RT-LAMP in 82 clinical blood samples using nested RT-PCR as a gold standard. RT-LAMP demonstrated a detection limit of 1 parasitized red blood cell (RBC)/500 mu l of blood for both Pfs16 and Pfs25 transcripts. For Pfs16 transcript, RT-LAMP detected all 30 samples positive by nested RT-PCR (100% sensitivity) and 1 in 52 samples negative by nested RT-PCR (98.1% specificity). For Pfs25 transcript, RT-LAMP detected all 15 samples positive by nested RT-PCR (100% sensitivity) and none of 67 samples negative by nested RT-PCR (100% specificity). Negative predictive value (NPV) and positive predictive value (PPV) of RT-LAMP for detection of Pfs16 transcript were 100% and 96.8%, respectively, and 100% for both when employing Pfs25 transcript. Detection rate of Pfs16 and Pfs25 transcripts by RI-LAMP in microscopically gametocyte-negative samples was 91.7% and 29.2%, respectively. Compared with nested RT-PCR, RT-LAMP had a higher sensitivity but similar specificity, with the advantage of a shorter assay time. As RT-LAMP requires very basic instruments and the results can be obtained by visual inspection, this technique provides a simple and reliable tool for epidemiological studies of malaria transmission and in gametocyte-targeted control programmes. (C) 2010 Elsevier Ireland Ltd. All rights reserved. C1 [Buates, Sureemas; Bantuchai, Sirasate; Tan-Ariya, Peerapan] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Han, Eun-Taek] Kangwon Natl Univ, Coll Med, Dept Parasitol, Chunchon 200701, South Korea. [Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Udomsangpetch, Rachanee] Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand. [Sirichaisinthop, Jeeraphat] Vector Borne Dis Training Ctr, Pra Budhabat 18120, Saraburi, Thailand. RP Tan-Ariya, P (reprint author), Mahidol Univ, Fac Sci, Dept Microbiol, Rama 6 Rd, Bangkok 10400, Thailand. EM scptn@mahidol.ac.th FU Mahidol University FX We thank the technical staff at the Entomology Department, AFRIMS, Bangkok, Thailand and at malaria clinic in Mae Sot and Mae Kasa, Tak Province, Thailand for their support in blood sample collection and microscopic examination. This work was supported by a grant for New and Mid-career Researchers of Mahidol University. NR 26 TC 26 Z9 28 U1 0 U2 9 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 1383-5769 J9 PARASITOL INT JI Parasitol. Int. PD SEP PY 2010 VL 59 IS 3 BP 414 EP 420 DI 10.1016/j.parint.2010.05.008 PG 7 WC Parasitology SC Parasitology GA 645MC UT WOS:000281461500017 PM 20542143 ER PT J AU Walters, SM Dubey, VS Jeffrey, NR Dixon, DR AF Walters, S. M. Dubey, V. S. Jeffrey, N. R. Dixon, D. R. TI Antibiotic-induced Porphyromonas gingivalis LPS release and inhibition of LPS-stimulated cytokines by antimicrobial peptides SO PEPTIDES LA English DT Article DE Porphyromonas gingivalis; Lipopolysaccharide; Antibiotics; Inflammation; Cytokines ID TUMOR-NECROSIS-FACTOR; HOST-DEFENSE PEPTIDES; INDUCED ENDOTOXIN RELEASE; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; IN-VITRO; LIPOPOLYSACCHARIDE; BACTERIA; INTERLEUKIN-1; CYTOTOXICITY AB Bacterial lipopolysaccharide (LPS) release during periodontal infection is a significant component of periodontal disease. We hypothesized that some bacterial LPS release results from bacterial exposure to antibiotics. Therefore, we examined the ability of various classes of antibiotics to induce LPS release from Porphyromonas gingivalis as well as the ability of antimicrobial peptides (AMPs) to inhibit purified LPS. All antibiotics tested against P. gingivalis were able to liberate 1.9-12.9 times more LPS as compared to untreated bacteria. Among the three AMPs tested. LL-37 was found to be the most potent inhibitor of cytokine (tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6) production and completely neutralized purified P. ginigivalis LPS activity in the chromogenic limulus amebocyte lysate (LAL) and whole blood cytokine stimulation assays. These observations suggest that therapeutic approaches utilizing AMPs as adjuncts to neutralize released LPS should be considered. Published by Elsevier Inc. C1 [Walters, S. M.; Dubey, V. S.; Jeffrey, N. R.; Dixon, D. R.] US Army Dent & Trauma Res Detachment, Walter Reed Army Inst Res, Immunol & Microbiol Branch, Great Lakes Naval Training Ctr, Great Lakes, IL 60088 USA. RP Dixon, DR (reprint author), US Army Dent Act & Clin Invest, Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. EM douglas.dixon@amedd.army.mil FU US Army Medical Research and Materiel Command for Dental Disease and Trauma Research FX This study was supported by the US Army Medical Research and Materiel Command for Dental Disease and Trauma Research and has been reviewed by the Walter Reed Army Institute of Research. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of Army or the Department of Defense. NR 35 TC 10 Z9 10 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-9781 J9 PEPTIDES JI Peptides PD SEP PY 2010 VL 31 IS 9 BP 1649 EP 1653 DI 10.1016/j.peptides.2010.06.001 PG 5 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy GA 644IL UT WOS:000281368400004 PM 20541574 ER PT J AU West, BJ Grigolini, P AF West, B. J. Grigolini, P. TI A psychophysical model of decision making SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Article DE Decision making; Probability; Inverse power law; 1/f noise ID INTERTEMPORAL CHOICES; TSALLIS STATISTICS; HUMAN COGNITION; 1/F NOISE; TIME; REGRET AB Herein we develop a psychophysical model of decision making based on the difference between objective clock time and the human brain's perception of time. In this model the utility function is given by the survival probability, which is shown to be a generalized hyperbolic distribution. The parameters of the utility function are fit to intertemporal choice model experimental data and decision making is determined to be a 1/f-noise process. Published by Elsevier B.V. C1 [West, B. J.] USA, Res Off, Informat Sci Directorate, Durham, NC 27709 USA. [Grigolini, P.] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. RP West, BJ (reprint author), USA, Res Off, Informat Sci Directorate, Durham, NC 27709 USA. EM bruce.j.west@us.army.mil FU ARO [W911NF-08-1-0117]; Welch [B-1577] FX P.G. thanks ARO (grant W911NF-08-1-0117) and Welch (grant B-1577) for financial support of this research work. NR 31 TC 5 Z9 5 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 J9 PHYSICA A JI Physica A PD SEP 1 PY 2010 VL 389 IS 17 BP 3580 EP 3587 DI 10.1016/j.physa.2010.03.039 PG 8 WC Physics, Multidisciplinary SC Physics GA 628KI UT WOS:000280118100026 ER PT J AU Cleland, JA Mintken, PE Carpenter, K Fritz, JM Glynn, P Whitman, J Childs, JD AF Cleland, Joshua A. Mintken, Paul E. Carpenter, Kristin Fritz, Julie M. Glynn, Paul Whitman, Julie Childs, John D. TI Examination of a Clinical Prediction Rule to Identify Patients With Neck Pain Likely to Benefit From Thoracic Spine Thrust Manipulation and a General Cervical Range of Motion Exercise: Multi-Center Randomized Clinical Trial SO PHYSICAL THERAPY LA English DT Article ID LOW-BACK-PAIN; PHYSICAL-THERAPY; PRACTICE GUIDELINES; DISABILITY INDEX; RATING-SCALES; CASE SERIES; DISORDERS; MANAGEMENT; RADICULOPATHY; QUESTIONNAIRE AB Background. A clinical prediction rule (CPR) purported to identify patients with neck pain who are likely to respond to thoracic spine thrust manipulation has recently been developed, but has yet to be validated. Objective. The purpose of this study was to examine the validity of this CPR. Design. This was a multi-center randomized clinical trial. Methods. One hundred forty patients with a primary report of neck pain were randomly assigned to receive either 5 sessions of stretching and strengthening exercise (exercise-only group) or 2 sessions of thoracic spine manipulation and cervical range of motion exercise followed by 3 sessions of stretching and strengthening exercise (manipulation + exercise group). Data on disability and pain were collected at baseline, 1 week, 4 weeks, and 6 months. The primary aim (treatment group x time x status on the prediction rule) was examined using a linear mixed model with repeated measures. Time, treatment group, and status on the rule, as well as all possible 2-way and 3-way interactions, were modeled as fixed effects, with disability (and pain) as the dependent variable. Effect sizes were calculated for both pain and disability at each follow-up period. Results. There was no 3-way interaction for either disability or pain. A 2-way (group x time) interaction existed for both disability and pain. Pair-wise comparisons of disability demonstrated that significant differences existed at each follow-up period between the manipulation + exercise group and the exercise-only group. The patients who received manipulation exhibited lower pain scores at the 1-week follow-up period. The effect sizes were moderate for disability at each follow-up period and were moderate for pain at the 1-week follow-up. Limitations. Different exercise approaches may have resulted in a different outcome. Conclusions. The results of the current study did not support the validity of the previously developed CPR. However, the results demonstrated that patients with mechanical neck pain who received thoracic spine manipulation and exercise exhibited significantly greater improvements in disability at both the short-and long-term follow-up periods and in pain at the 1-week follow-up compared with patients who received exercise only. C1 [Cleland, Joshua A.] Franklin Pierce Univ, Phys Therapy Dept, Concord, NH 03301 USA. [Cleland, Joshua A.] Concord Hosp, Rehabil Serv, Concord, NH USA. [Mintken, Paul E.] Univ Colorado, Dept Phys Therapy, Sch Med, Aurora, CO USA. [Mintken, Paul E.] Univ Colorado, Lead Clinician Wardenburg Hlth Ctr, Boulder, CO 80309 USA. [Carpenter, Kristin] Waldrons Peak Phys Therapy, Phys Therapist, Boulder, CO USA. [Fritz, Julie M.] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA. [Fritz, Julie M.] Intermountain Hlth Care, Clin Outcomes Res Sci, Salt Lake City, UT USA. [Glynn, Paul] Newton Wellesley Hosp, Newton, MA USA. [Whitman, Julie] Motions Orthoped Manual Phys Therapy Program, Louisville, KY USA. [Whitman, Julie] Regis Univ, Sch Phys Therapy, Denver, CO USA. [Childs, John D.] Baylor Univ, US Army, Doctoral Program Phys Therapy, San Antonio, TX USA. RP Cleland, JA (reprint author), Franklin Pierce Univ, Phys Therapy Dept, 5 Chenell Dr, Concord, NH 03301 USA. EM joshcleland@comcast.net OI Mintken, Paul/0000-0002-1427-2424 FU Foundation for Physical Therapy; Orthopaedic Section of the American Physical Therapy Association FX Funding was provided by the Foundation for Physical Therapy and the Orthopaedic Section of the American Physical Therapy Association. NR 42 TC 45 Z9 48 U1 0 U2 10 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD SEP PY 2010 VL 90 IS 9 BP 1239 EP 1250 DI 10.2522/ptj.20100123 PG 12 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 649PI UT WOS:000281784100003 PM 20634268 ER PT J AU Adams, P George, K Stephens, M Brucker, KA O'Shea, TT Dommermuth, DG AF Adams, Paul George, Kevin Stephens, Mike Brucker, Kyle A. O'Shea, Thomas T. Dommermuth, Douglas G. TI A numerical simulation of a plunging breaking wave SO PHYSICS OF FLUIDS LA English DT Editorial Material DE flow simulation; waves C1 [Adams, Paul; George, Kevin; Stephens, Mike] USA, Unclassified Data Anal & Assessment Ctr, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Brucker, Kyle A.; O'Shea, Thomas T.; Dommermuth, Douglas G.] Sci Applicat Int Corp, San Diego, CA 92121 USA. RP Adams, P (reprint author), USA, Unclassified Data Anal & Assessment Ctr, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 2 TC 2 Z9 2 U1 1 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1070-6631 J9 PHYS FLUIDS JI Phys. Fluids PD SEP PY 2010 VL 22 IS 9 AR 091111 DI 10.1063/1.3487758 PG 1 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA 657TQ UT WOS:000282437100011 ER PT J AU Seyfer, AE Fox, JP Hamilton, CG AF Seyfer, Alan E. Fox, Justin P. Hamilton, Conrad G. TI Poland Syndrome: Evaluation and Treatment of the Chest Wall in 63 Patients SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID RECONSTRUCTION AB Background: Poland syndrome is a sporadic, congenital unilateral absence of the sternocostal head of the pectoralis major muscle that can occur with other ipsilateral chest wall and limb derangements. The chest wall deficiency is primarily cosmetic, its incidence is unknown, male patients may be affected more than female patients, the right side is affected more than the left, and associated comorbidities may exist. Chest wall repair depends on anatomical type and gender. Methods: Sixty-three patients with Poland syndrome were divided into two treatment groups by chest wall anatomy and gender. Surgical repair was based on this division. Seventy-six operations were performed by the senior author (A. E. S.) during a 30-year period, and long-term outcomes are presented. Corrective methods included use of custom-made chest wall prostheses, mammary prostheses, latissimus dorsi muscle transfers, transverse rectus abdominis musculocutaneous flaps, sternal/rib reconstruction, or a combination of methods. Follow-up ranged from 1 to 21 years. Results: Two anatomical forms of the disorder are described, each with unique surgical requirements. The simple deformity was effectively repaired with a latissimus dorsi muscle transfer plus, in female patients, a sublatissimus mammary prosthesis. Repair of the complex deformity, in addition to the latissimus transfer, selectively included musculoskeletal chest wall realignment. Custom-made chest wall prostheses carried a higher risk of complications. Conclusions: Poland syndrome of the chest wall exists in two forms: the more common simple variety and a complex form (as originally described by Poland). Repair of the chest wall can be effectively tailored to these anatomical types, gender, and patient preference. (Plast. Reconstr. Surg. 126: 902, 2010.) C1 [Seyfer, Alan E.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Plast Surg Serv, Washington, DC 20307 USA. Wright State Univ, Dept Surg, Wright Patterson AFB, OH USA. Wright Patterson US AF Med Ctr, Wright Patterson AFB, OH USA. Univ New Mexico, Sch Med, Dept Surg Gen Surg, Albuquerque, NM 87131 USA. RP Seyfer, AE (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM aseyfer@usuhs.mil NR 28 TC 15 Z9 16 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD SEP PY 2010 VL 126 IS 3 BP 902 EP 911 DI 10.1097/PRS.0b013e3181e60435 PG 10 WC Surgery SC Surgery GA 647GP UT WOS:000281606700022 PM 20811224 ER PT J AU Lim, J Chen, WNW Zheng, JQ AF Lim, Jaeyoung Chen, Weinong W. Zheng, James Q. TI Dynamic small strain measurements of Kevlar (R) 129 single fibers with a miniaturized tension Kolsky bar SO POLYMER TESTING LA English DT Article DE Dynamic strain measurement; High-performance single fibers; Non-contact laser technique; Kolsky bar ID HOPKINSON-PRESSURE-BAR; PULSE SHAPING TECHNIQUES; COMPRESSION AB We adopted a non-contact laser technique to measure axial small strain (< similar to 5%) of Kevlar (R) 129 fibers in a miniaturized tension Kolsky bar. Accurate small strain measurement is necessary to determine the elastic response of the fibers. In this optical arrangement, a laser beam passes through a line generator lens, which is known as a Powell glass, yielding a thin sheet of light with uniform intensity. This laser sheet passes through a gap formed by the fixture holding the fiber specimen. As the specimen is stretched, an increasing amount of light passes through the gap, which is measured by a high-speed, high resolution photo-detector mounted on the other side of the gap. Dynamic tensile experiments performed at a constant strain rate of similar to 1500/s on Kevlar (R) 129 fibers demonstrate the capability of this non-contact laser technique in the determination of dynamic tensile strain histories with low amplitudes. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Lim, Jaeyoung; Chen, Weinong W.] Purdue Univ, Sch Aeronaut Astronaut, W Lafayette, IN 47907 USA. [Lim, Jaeyoung; Chen, Weinong W.] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. [Zheng, James Q.] USA, PM Soldier Equipment, Haymarket, VA 20169 USA. RP Chen, WNW (reprint author), Purdue Univ, Sch Aeronaut Astronaut, W Lafayette, IN 47907 USA. EM wchen@purdue.edu NR 14 TC 15 Z9 15 U1 3 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-9418 J9 POLYM TEST JI Polym. Test PD SEP PY 2010 VL 29 IS 6 BP 701 EP 705 DI 10.1016/j.polymertesting.2010.05.012 PG 5 WC Materials Science, Characterization & Testing; Polymer Science SC Materials Science; Polymer Science GA 635KY UT WOS:000280655300010 ER PT J AU Lavoie, JH AF Lavoie, Joseph H. TI A Review of Nanomaterial Safety Concerns SO PROCESS SAFETY PROGRESS LA English DT Article DE nanoparticles; nanotubes; environment; hazards; resources ID NANOPARTICLES; PENETRATION AB Nanomaterials are quickly moving from research benches to the manufacturing environment and into product lines These materials pose unique safety concerns. which should be made clear to both the workers and the consumers who are exposed to them The following is a summary of documents concerning the dangers posed by a wide variety of nanomaterials as well as references; which may be useful to practicing process engineers and El-IS professionals (C) 2010 American institute of Chemical Engineers Process Saf Prog 29 182-185, 2010 C1 USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Lavoie, JH (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. NR 24 TC 1 Z9 1 U1 0 U2 3 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1066-8527 J9 PROCESS SAF PROG JI Process Saf. Prog. PD SEP PY 2010 VL 29 IS 3 BP 182 EP 185 DI 10.1002/prs.10388 PG 4 WC Engineering, Chemical SC Engineering GA 640YR UT WOS:000281090700002 ER PT J AU Levine, F La Scala, J Kosik, W AF Levine, Felicia La Scala, John Kosik, Wendy TI Properties of clear polyurethane films modified with a fluoropolymer emulsion SO PROGRESS IN ORGANIC COATINGS LA English DT Review DE Lumiflon; Fluoropolymer emulsion; CARC; Waterborne polyurethane topcoat; Fluorine surface enrichment; XPS AB An emulsion of a fluoroethylene vinyl ether polyol, Lumiflon FE-4400, was incorporated into clearcoats of two-part water-based military polyurethane topcoats. This additive was mixed with the aqueous dispersion polyol component. The polyol component was then mixed with the isocyanate component with a high speed disperser to properly mix the reactants. Films were prepared by drawing down the dispersion onto glass substrates using a 4-mil stainless steel Bird applicator. After drying at ambient conditions the films were removed from the glass for analysis. As measured using X-ray photoelectron spectroscopy, Lumiflon FE-4400 segregated to the surface providing significant fluorine enrichment at the air interface, as high as 90 times the bulk concentration. Although increasing the concentration of Lumiflon FE-4400 increased the surface concentration, the ratio of surface concentration to the bulk concentration decreased. As expected, water contact angle increased approximately in a linear fashion with the surface fluorine concentration. At 1-5 wt% added Lumifion FE-4400, the physical and mechanical properties were not significantly affected. However, addition of Lumiflon FE-4400 at or above 10% of polyol fraction significantly reduced the glass transition temperature, modulus. crosslink density, strength, toughness and weathering resistance. Phase contrast microscopy showed that the morphology of these films went from being uniform to having distinct aggregates that increased in size and number as fluorinated polyol fraction increased, likely explaining the reduction in film properties. Accelerated weathering of pigmented coatings was also performed. Although fluorinated resins typically improve weathering resistance of coatings, in this study, increasing the Lumiflon FE-4400 content decreased the weathering resistance as a result of the ethoxylation of the fluorinated additive necessary to produce an aqueous fluoropolymer emulsion. Published by Elsevier B.V. C1 [Levine, Felicia; La Scala, John; Kosik, Wendy] USA, Dept Army, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. RP La Scala, J (reprint author), USA, Dept Army, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. EM felicia.levine@us.army.mil FU Strategic Environmental Research and Development Program (SERDP) [WP-1521] FX The authors would like to thank John Escarsega for formulation guidance and technical support, Eugene Napadensky for guidance on permeability testing, Dr. Ralph Adler for editing this paper and the Strategic Environmental Research and Development Program (SERDP WP-1521) for funding this study. NR 18 TC 25 Z9 26 U1 6 U2 58 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0300-9440 J9 PROG ORG COAT JI Prog. Org. Coat. PD SEP PY 2010 VL 69 IS 1 BP 63 EP 72 DI 10.1016/j.porgcoat.2010.05.006 PG 10 WC Chemistry, Applied; Materials Science, Coatings & Films SC Chemistry; Materials Science GA 635DC UT WOS:000280634800012 ER PT J AU Furusato, B Tan, SH Young, D Dobi, A Sun, C Mohamed, AA Thangapazham, R Chen, Y McMaster, G Sreenath, T Petrovics, G McLeod, DG Srivastava, S Sesterhenn, IA AF Furusato, B. Tan, S-H Young, D. Dobi, A. Sun, C. Mohamed, A. A. Thangapazham, R. Chen, Y. McMaster, G. Sreenath, T. Petrovics, G. McLeod, D. G. Srivastava, S. Sesterhenn, I. A. TI ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification SO PROSTATE CANCER AND PROSTATIC DISEASES LA English DT Article DE ERG; oncoprotein; prostatic intraepithelial neoplasia; clonal selection; patient stratification ID TMPRSS2-ERG FUSION; GENE FUSIONS; OVEREXPRESSION; DIFFERENTIATION; TRANSFORMATION; HETEROGENEITY; CARCINOMA; TISSUES; MYC AB Gene fusions prevalent in prostate cancer (CaP) lead to the elevated expression of the ERG protooncogene. ERG activation present in 50-70% of prostate tumors underscores one of the most common oncogenic alterations in CaP. Despite numerous reports of gene fusions and mRNA expression, ERG oncoprotein status in CaP still remains to be defined. Furthermore, development of ERG protein-based assays may provide a new dimension to evaluation of gene fusions involving diverse androgen-regulated promoters and the ERG protein-coding sequence. Through exhaustive evaluations of 132 whole-mount prostates (261 tumor foci and over 200 000 benign glands) for the ERG oncoprotein nuclear expression, we demonstrated 99.9% specificity for detecting prostate tumor cells using a highly specific anti-ERG monoclonal antibody. The ERG oncoprotein expression correlated well with fusion transcript or gene fusion in randomly selected specimens. Strong concordance of ERG-positive foci of prostatic intraepithelial neoplasia (PIN) with ERG-positive carcinoma (82 out of 85 sections with PIN, 96.5%) affirms the biological role of ERG in clonal selection of prostate tumors in 65% (86 out of 132) of patients. Conversely, ERG negative PINs were associated with ERG-negative carcinoma. Taken together, the homogeneous and strong ERG expression detected in individual tumors establishes the potential for ERG oncoprotein-based stratification of CaP. Prostate Cancer and Prostatic Diseases (2010) 13, 228-237; doi:10.1038/pcan.2010.23; published online 29 June 2010 C1 [Furusato, B.; Young, D.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Furusato, B.; Tan, S-H; Dobi, A.; Sun, C.; Mohamed, A. A.; Thangapazham, R.; Chen, Y.; Sreenath, T.; Petrovics, G.; McLeod, D. G.; Srivastava, S.] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. [McMaster, G.] Affymetrix Inc, Fremont, CA USA. [McLeod, D. G.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. RP Sesterhenn, IA (reprint author), Armed Forces Inst Pathol, Dept Genitourinary Pathol, 6825 16th St NW, Washington, DC 20306 USA. EM ssrivastava@cpdr.org; sesterhe@afip.osd.mil OI Tan, Shyh-Han/0000-0001-8250-7005; Furusato, Bungo/0000-0003-4614-9882 FU DoD, CDMRP [PC073614]; Center for Prostate Disease [HU001-04-C-1502]; [RO1 DK065977] FX We thank Ms Amina Ali, Mr Zhe Chang and Ms Lakshmi Ravindranath for outstanding medical informatics, biospecimen banking and technical assistance. This research was supported by Grants RO1 DK065977 to SS and GP; DoD, CDMRP, Grant PC073614 to SS, TS and AD; and Center for Prostate Disease Research Program HU001-04-C-1502 to DGM. NR 27 TC 135 Z9 139 U1 1 U2 7 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1365-7852 J9 PROSTATE CANCER P D JI Prostate Cancer Prostatic Dis. PD SEP PY 2010 VL 13 IS 3 BP 228 EP 237 DI 10.1038/pcan.2010.23 PG 10 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 638RQ UT WOS:000280914000004 PM 20585344 ER PT J AU Dachman, AH Obuchowski, NA Hoffmeister, JW Hinshaw, JL Frew, MI Winter, TC Van Uitert, RL Periaswamy, S Summers, RM Hillman, BJ AF Dachman, Abraham H. Obuchowski, Nancy A. Hoffmeister, Jeffrey W. Hinshaw, J. Louis Frew, Michael I. Winter, Thomas C. Van Uitert, Robert L. Periaswamy, Senthil Summers, Ronald M. Hillman, Bruce J. TI Effect of Computer-aided Detection for CT Colonography in a Multireader, Multicase Trial SO RADIOLOGY LA English DT Article ID ASSISTED READER SOFTWARE; TOMOGRAPHIC COLONOGRAPHY; POLYP DETECTION; DETECTION CAD; VIRTUAL COLONOSCOPY; 2ND READER; PRIMARY 2D; PERFORMANCE; PARADIGM; SENSITIVITY AB Purpose: To assess the effect of using computer-aided detection (CAD) in second-read mode on readers' accuracy in interpreting computed tomographic (CT) colonographic images. Materials and Methods: The contributing institutions performed the examinations under approval of their local institutional review board, with waiver of informed consent, for this HIPAA-compliant study. A cohort of 100 colonoscopy-proved cases was used: In 52 patients with findings positive for polyps, 74 polyps of 6 mm or larger were observed in 65 colonic segments; in 48 patients with findings negative for polyps, no polyps were found. Nineteen blinded readers interpreted each case at two different times, with and without the assistance of a commercial CAD system. The effect of CAD was assessed in segment-level and patient-level receiver operating characteristic (ROC) curve analyses. Results: Thirteen (68%) of 19 readers demonstrated higher accuracy with CAD, as measured with the segment-level area under the ROC curve (AUC). The readers' average segment-level AUC with CAD (0.758) was significantly greater (P = .015) than the average AUC in the unassisted read (0.737). Readers' per-segment, per-patient, and per-polyp sensitivity for all polyps of 6 mm or larger was higher (P < .011,.007,.005, respectively) for readings with CAD compared with unassisted readings (0.517 versus 0.465, 0.521 versus 0.466, and 0.477 versus 0.422, respectively). Sensitivity for patients with at least one large polyp of 10 mm or larger was also higher (P < .047) with CAD than without (0.777 versus 0.743). Average reader sensitivity also improved with CAD by more than 0.08 for small adenomas. Use of CAD reduced specificity of readers by 0.025 (P = .05). Conclusion: Use of CAD resulted in a significant improvement in overall reader performance. CAD improves reader sensitivity when measured per segment, per patient, and per polyp for small polyps and adenomas and also reduces specificity by a small amount. (C) RSNA, 2010 C1 [Dachman, Abraham H.] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA. [Obuchowski, Nancy A.] Cleveland Clin, Dept Quantitat Hlth Sci, Cleveland, OH USA. [Hoffmeister, Jeffrey W.; Van Uitert, Robert L.; Periaswamy, Senthil] ICAD, Nashua, NH USA. [Hinshaw, J. Louis] Univ Wisconsin Hosp & Clin, Dept Radiol, Madison, WI USA. [Frew, Michael I.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Winter, Thomas C.] Univ Utah, Dept Radiol, Salt Lake City, UT 84132 USA. [Summers, Ronald M.] Natl Inst Hlth Clin Ctr, Imaging Biomarkers & Computer Aided Diag Lab, Dept Radiol & Imaging Sci, Bethesda, MD USA. [Hillman, Bruce J.] Univ Virginia Hlth Syst, Dept Radiol Res, Charlottesville, VA USA. RP Dachman, AH (reprint author), Univ Chicago, Dept Radiol, MC2026,5841 S Maryland Ave, Chicago, IL 60637 USA. EM ahdachma@uchicago.edu FU National Institutes of Health Clinical Center FX R.M.S. is an employee of and this research was supported by the National Institutes of Health Clinical Center. NR 39 TC 52 Z9 53 U1 0 U2 2 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0033-8419 J9 RADIOLOGY JI Radiology PD SEP PY 2010 VL 256 IS 3 BP 827 EP 835 DI 10.1148/radiol.10091890 PG 9 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 656LD UT WOS:000282335300017 PM 20663975 ER PT J AU Mal, S Narayan, J Nori, S Prater, JT Kumar, D AF Mal, Siddhartha Narayan, J. Nori, Sudhakar Prater, J. T. Kumar, D. TI Defect-mediated room temperature ferromagnetism in zinc oxide SO SOLID STATE COMMUNICATIONS LA English DT Article DE Magnetic semiconductor; Thin films; Laser irradiation; Oxygen and zinc vacancies ID DOPED ZNO; MAGNETIC-PROPERTIES; FILMS AB We have introduced systematic changes in the electrical, magnetic and optical properties of undoped ZnO films through irradiation with an UV Excimer laser. Increases in the electrical conductivity and magnetic moment have been controlled precisely with the number of laser pulses, without altering the Wurtzite crystal structure and n-type semiconducting characteristics of the films. The laser induced ferromagnetism and concomitant conductivity enhancement can be reversed through subsequent thermal annealing. Hence, we have successfully demonstrated reversible switching of RTFM in undoped ZnO by employing oxygen annealing (off) and laser irradiation (on). We discuss these findings in terms of defects and defect complexes created by pulsed laser irradiation. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Mal, Siddhartha; Narayan, J.; Nori, Sudhakar] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, J. T.] USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Kumar, D.] N Carolina Agr & Tech State Univ, Dept Mech Engn, Greensboro, NC 27411 USA. RP Mal, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM smal@ncsu.edu RI Nori, Sudhakar/E-8111-2010 FU Army Research Office [W911NF-04-D-0003]; National Science Foundation [NSF 0653722] FX The authors are pleased to acknowledge the support of the Army Research Office under grant W911NF-04-D-0003 and the National Science Foundation under grant NSF 0653722. The authors are also pleased to acknowledge theoretical discussions with Professor Sok T. Pantelides, ORNL and Vanderbilt University. NR 27 TC 22 Z9 22 U1 3 U2 20 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1098 J9 SOLID STATE COMMUN JI Solid State Commun. PD SEP PY 2010 VL 150 IS 35-36 BP 1660 EP 1664 DI 10.1016/j.ssc.2010.06.030 PG 5 WC Physics, Condensed Matter SC Physics GA 642LZ UT WOS:000281216800016 ER PT J AU Tanner, CL Ammer, FK Barry, RE Stromdahl, EY AF Tanner, Cheryl L. Ammer, Frank K. Barry, Ronald E. Stromdahl, Ellen Y. TI Tick Burdens on Peromyscus leucopus Rafinesque and Infection of Ticks by Borrelia spp. in Virginia SO SOUTHEASTERN NATURALIST LA English DT Article ID AMBLYOMMA-AMERICANUM ACARI; LYME-DISEASE SPIROCHETE; WHITE-FOOTED MICE; CHIPMUNK TAMIAS-STRIATUS; IXODES-SCAPULARIS ACARI; BURGDORFERI SENSU-LATO; UNITED-STATES; DERMACENTOR-VARIABILIS; POPULATION ATTRIBUTES; RESERVOIR COMPETENCE AB The emergence of Southern Tick-Associated Rash Illness (STARI) questions the validity of reported Lyme disease (LD) cases throughout the southern United States. Acute symptoms are identical, and an efficient method of diagnosis is currently unavailable, with the cause(s) in question. The etiologic agent of LD, Borrelia burgdorferi, is transmitted by Ixodes scapularis (Black-legged Tick), while Amblyomma americanum (Lone Star Tick) is known to carry B. lonestari, the bacterium associated with cases of STARI. Peromyscus leucopus (White-footed Mouse) is a very efficient reservoir for these bacteria and tolerant of their vectors. We sampled small (<3 ha) and large (>3 ha) forest patches in Virginia for tick densities, burdens, and infestation rates by collecting ticks by drag sampling and from mice. We also tested ticks for infection by Borrelia. Although mouse density was greater in small patches, tick densities, burdens, and infestation rates did not differ with patch size. B. burgdorferi was not detected in any tick species, but 3.4% of nymphal and 5.9% of adult Lone Star Ticks removed from vegetation were infected with B. lonestari. C1 [Tanner, Cheryl L.] US Forest Serv, USDA, Richwood, WV 26261 USA. [Ammer, Frank K.] Frostburg State Univ, Dept Biol, Frostburg, MD 21532 USA. [Barry, Ronald E.] Bates Coll, Dept Biol, Lewiston, ME 04240 USA. [Stromdahl, Ellen Y.] USA, Entomol Sci Program, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Tanner, CL (reprint author), US Forest Serv, USDA, 932 N Fork Cherry Rd, Richwood, WV 26261 USA. EM ctanner.eco@gmail.com FU National Park Service (NPS) [1443DCA309701200] FX Field housing, equipment, and funding were provided by the National Park Service (NPS) under Cooperative Agreement 1443DCA309701200 with Ronald Barry. NPS Natural Resource Manager Gregg Kneipp provided GIS maps and frequent general support. We thank Dr. William Seddon and the Frostburg State University Department of Biology for providing laboratory supplies. We also thank Mrs. Valerie Fritz for obtaining both field and laboratory supplies and Ms. Bebe Elrick for her continuous help and support. C. L. Tanner thanks her family for their unyielding support, encouragement, and confidence. NR 85 TC 1 Z9 1 U1 0 U2 12 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 EI 1938-5412 J9 SOUTHEAST NAT JI Southeast. Nat. PD SEP PY 2010 VL 9 IS 3 BP 529 EP 546 DI 10.1656/058.009.0311 PG 18 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA V24FZ UT WOS:000208397600011 ER PT J AU Delaney, DK Carlile, LD AF Delaney, David K. Carlile, Lawrence D. TI Kleptoparasitism of a Red-cockaded Woodpecker (Picoides borealis) Nest Cavity by a Red-bellied Woodpecker (Melanerpes carolinus) SO SOUTHEASTERN NATURALIST LA English DT Article AB We report the kleptoparasitism of a Picoides borealis (Red-cockaded Woodpecker) cavity by a Melanerpes carolinus (Red-bellied Woodpecker). We believe this is the first video documenting kleptoparasitism of a Red-cockaded Woodpecker nest by a male Red-bellied Woodpecker in which both a nestling and an attending adult Red-cockaded Woodpecker adult were forcibly ejected. The Red-bellied Woodpecker was resolute in its attempt to usurp the nest, reaching into the cavity over 2000 times in an attempt to evict the cavity occupants. The male Red-bellied Woodpecker and his mate took over the cavity soon after. Adult Red-cockaded Woodpeckers continued to visit their nest cavity during diurnal hours for 2 days post-kleptoparasitism. It is important that resource managers incorporate proactive management techniques to lessen the impact of interspecific competition for cavities, especially in smaller or fragmented Red-cockaded Woodpecker populations. C1 [Delaney, David K.] USA, Construct Engn Res Lab, Champaign, IL 61826 USA. [Carlile, Lawrence D.] Directorate Publ Works, Environm Div, Fish & Wildlife Branch, Ft Stewart, GA 31314 USA. RP Delaney, DK (reprint author), USA, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM David.Delaney@erdc.usace.army.mil FU US Army Forces Command; Fort Stewart Army Installation; Strategic Environmental Research and Development Program [CS-1083]; Construction Engineering Research Laboratory, which is part of the Engineer Research and Development Center for the US Army Corps of Engineers FX This study was supported by US Army Forces Command and Fort Stewart Army Installation with funding from the Strategic Environmental Research and Development Program, under Conservation Project No. CS-1083 and the Construction Engineering Research Laboratory, which is part of the Engineer Research and Development Center for the US Army Corps of Engineers. The Fish and Wildlife Branch at Fort Stewart provided logistical support and conducted most RCWO nest surveys. We thank T. Brewton, H. Erickson, M. Fay, T. Hasty, M. Huffman, M. Klich, S. Kovac, B. Platt, A. Rinker, and A. Walde for assisting with data collection. We thank T. Brewton, T. Grubb, and A. Walde for assisting in placing video cameras and A. Cone, B. MacAllister, L. Nguyen, C. Smith, and A. Walde for assisting in reviewing videotapes. We thank T. Hayden for his comments and suggestions on an earlier draft of this manuscript. We also thank two anonymous reviewers for their helpful comments. NR 21 TC 1 Z9 1 U1 2 U2 5 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 J9 SOUTHEAST NAT JI Southeast. Nat. PD SEP PY 2010 VL 9 IS 3 BP 624 EP 628 DI 10.1656/058.009.0318 PG 5 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA V24FZ UT WOS:000208397600018 ER PT J AU Walter, RJ AF Walter, Robert J. TI THE CONSISTENT ETHIC OF LIFE: ASSESSING ITS RECEPTION AND RELEVANCE SO THEOLOGICAL STUDIES LA English DT Book Review C1 [Walter, Robert J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Walter, RJ (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU THEOLOGICAL STUDIES INC PI WASHINGTON PA GEORGETOWN UNIV,, WASHINGTON, DC 20057 USA SN 0040-5639 J9 THEOL STUD JI Theol. Stud. PD SEP PY 2010 VL 71 IS 3 BP 761 EP 762 PG 2 WC Religion SC Religion GA 635TY UT WOS:000280680700053 ER PT J AU Merritt, EK Cannon, MV Hammers, DW Le, LN Gokhale, R Sarathy, A Song, TJ Tierney, MT Suggs, LJ Walters, TJ Farrar, RP AF Merritt, Edward K. Cannon, Megan V. Hammers, David W. Le, Long N. Gokhale, Rohit Sarathy, Apurva Song, Tae J. Tierney, Matthew T. Suggs, Laura J. Walters, Thomas J. Farrar, Roger P. TI Repair of Traumatic Skeletal Muscle Injury with Bone-Marrow-Derived Mesenchymal Stem Cells Seeded on Extracellular Matrix SO TISSUE ENGINEERING PART A LA English DT Article ID STROMAL CELLS; ACELLULAR MATRIX; SATELLITE CELL; COLLATERAL PERFUSION; IN-VITRO; REGENERATION; TISSUE; RAT; DIFFERENTIATION; RECONSTRUCTION AB Skeletal muscle injury resulting in tissue loss poses unique challenges for surgical repair. Despite the regenerative potential of skeletal muscle, if a significant amount of tissue is lost, skeletal myofibers will not grow to fill the injured area completely. Prior work in our lab has shown the potential to fill the void with an extracellular matrix (ECM) scaffold, resulting in restoration of morphology, but not functional recovery. To improve the functional outcome of the injured muscle, a muscle-derived ECM was implanted into a 1 X 1 cm(2), full-thickness defect in the lateral gastrocnemius (LGAS) of Lewis rats. Seven days later, bone-marrow-derived mesenchymal stem cells (MSCs) were injected directly into the implanted ECM. Partial functional recovery occurred over the course of 42 days when the LGAS was repaired with an MSC-seeded ECM producing 85.4 +/- 3.6% of the contralateral LGAS. This was significantly higher than earlier recovery time points (p<0.05). The specific tension returned to 94 +/- 9% of the contralateral limb. The implanted MSC-seeded ECM had more blood vessels and regenerating skeletal myofibers than the ECM without cells (p<0.05). The data suggest that the repair of a skeletal muscle defect injury by the implantation of a muscle-derived ECM seeded with MSCs can improve functional recovery after 42 days. C1 [Merritt, Edward K.; Cannon, Megan V.; Hammers, David W.; Le, Long N.; Gokhale, Rohit; Sarathy, Apurva; Song, Tae J.; Tierney, Matthew T.; Farrar, Roger P.] Univ Texas Austin, Dept Kinesiol, Austin, TX 78712 USA. [Suggs, Laura J.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA. [Walters, Thomas J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Farrar, RP (reprint author), Univ Texas Austin, Dept Kinesiol, 1 Univ Stn D3700, Austin, TX 78712 USA. EM rfarrar@mail.utexas.edu FU U.S. Army MRMC [DAMD W81XWH-06-1-0540] FX This work was funded by the U.S. Army MRMC grant DAMD W81XWH-06-1-0540. NR 71 TC 52 Z9 53 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 J9 TISSUE ENG PT A JI Tissue Eng. Part A PD SEP PY 2010 VL 16 IS 9 BP 2871 EP 2881 DI 10.1089/ten.tea.2009.0826 PG 11 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 643IJ UT WOS:000281288500015 PM 20412030 ER PT J AU Desmond, DE McFaul, S AF Desmond, D. E. McFaul, S. TI Characterization of Platelet Aggregation Inhibition Activity in Supernates from Red Blood Cells Stored in AS-5 SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting 2010 CY OCT 09-12, 2010 CL Baltimore, MD SP AABB C1 [McFaul, S.] USA, Inst Surg Res, San Antonio, TX USA. [Desmond, D. E.] Natl Naval Med Ctr, Bethesda, MD USA. EM deirdre.desmond@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2010 VL 50 SU 2 BP 69A EP 69A PG 1 WC Hematology SC Hematology GA 649JM UT WOS:000281764900164 ER PT J AU Gilstad, CW Wells, J AF Gilstad, C. W. Wells, J. TI Passenger Lymphocyte Syndrome in a Blood Group: A Combat Casualty Resuscitated with Blood Group O Red Blood Cells SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting 2010 CY OCT 09-12, 2010 CL Baltimore, MD SP AABB C1 [Gilstad, C. W.; Wells, J.] Natl Naval Med Ctr, Bethesda, MD USA. [Wells, J.] Walter Reed Army Med Ctr, Pathol & Lab Serv, Washington, DC 20307 USA. EM colleen.gilstad@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2010 VL 50 SU 2 BP 134A EP 134A PG 1 WC Hematology SC Hematology GA 649JM UT WOS:000281764900334 ER PT J AU Nunez, TC Dutton, WD May, AK Holcomb, JB Young, PP Cotton, BA AF Nunez, Timothy C. Dutton, William D. May, Addison K. Holcomb, John B. Young, Pampee P. Cotton, Bryan A. TI Emergency department blood transfusion predicts early massive transfusion and early blood component requirement SO TRANSFUSION LA English DT Article ID DAMAGE CONTROL RESUSCITATION; FRESH-FROZEN PLASMA; I TRAUMA CENTER; LIFE-THREATENING COAGULOPATHY; LAST 60 YEARS; COMBAT CASUALTIES; EXSANGUINATION PROTOCOL; PRODUCT UTILIZATION; CONTROL HEMATOLOGY; WHOLE-BLOOD AB BACKGROUND: The purpose of this study was to evaluate the ability of uncrossmatched transfusions in the emergency department (ED) to predict early (< 6 hr) massive transfusion (MT) of red blood cells (RBCs) and blood components. STUDY DESIGN AND METHODS: All patients admitted to a Level 1 trauma center between July 2005 and June 2007 who received any transfusions and were transported directly from the scene of injury were included. Early MT was defined as the need for 10 U or more or RBCs in the first 6 hours. Early MT plasma was defined as 6 U or more of plasma in the first 6 hours. Early MT platelets (PLTs) were defined as two or more apheresis transfusions in the first 6 hours. Univariate and multivariate analyses were performed. RESULTS: A total of 485 patients (34%) received ED transfusions (ED RBC+) and 956 (66%) did not receive ED transfusions (ED RBC-). ED RBC+ patients were younger, were more likely to be male, and arrived with more severe injuries. Multivariate regression identified ED transfusion of uncrossmatched RBC as an independent predictor of requiring early MT of RBCs (odds ratio [OR], 3.5; 95% confidence interval [CI], 1.36-7.59; p = 0.001), plasma (OR, 2.7; 95% CI, 1.66-4.39; p < 0.001), and PLTs (OR, 1.9; 95% CI, 1.08-3.41; p = 0.025). CONCLUSION: Patients receiving uncrossmatched RBCs in the ED are more than three times more likely to receive early MT of RBCs. Additionally, patients transfused with ED RBCs are more likely to receive 6 units or more of plasma and two or more apheresis PLT transfusions. Given these findings, ED transfusion of uncrossmatched RBCs should be considered a potential trigger for activation of an institution's MT protocol. C1 [Cotton, Bryan A.] Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, Houston, TX 77030 USA. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. Vanderbilt Univ, Med Ctr, Dept Surg, Nashville, TN USA. Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA. Univ Texas Hlth Sci Ctr, Dept Surg, Houston, TX 77030 USA. RP Cotton, BA (reprint author), Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, 6410 Fannin,Suite 1100, Houston, TX 77030 USA. EM bryan.a.cotton@uth.tmc.edu NR 50 TC 18 Z9 19 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2010 VL 50 IS 9 BP 1914 EP 1920 DI 10.1111/j.1537-2995.2010.02682.x PG 7 WC Hematology SC Hematology GA 646OZ UT WOS:000281553200010 PM 20456707 ER PT J AU Han, ET Lee, WJ Sattabongkot, J Jang, JW Nam, MH An, SSA Suh, I Lim, CS AF Han, Eun Taek Lee, Won Ja Sattabongkot, Jetsumon Jang, Jin Woo Nam, Myoung Hyun An, Seong Soo A. Suh, InBum Lim, Chae Seung TI Sequence polymorphisms of Plasmodium vivax ookinete surface proteins (Pvs25 and Pvs28) from clinical isolates in Korea SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE Plasmodium vivax; Ookinete surface protein; Pvs25; Pvs28; Malaria vaccine ID TRANSMISSION-BLOCKING VACCINE; MALARIA; CANDIDATES AB P>The Ookinete surface proteins of Plasmodium vivax (P. vivax), Pvs25 and Pvs28, were candidates for the transmission blocking vaccine (TBV), which exhibited great antigenic diversities among various isolates. Polymorphisms of these genes in the isolates from Republic of Korea (ROK) were analysed, which provided valuable baseline data for the field trials of TBV-based vaccines. A total of 98 isolates were collected over 11 years from 1996 to 2007. pvs25 and pvs28 genes from the above isolates were amplified, sequenced and compared against Sal-1 strain. Sequencing analysis of PCR products from P. vivax pvs25 revealed two allelic types, Q97T130 and E97/T130 alleles with the frequencies of 54.5% and 45.5%, respectively, in comparison with Sal I type sequence (E97/I130). From pvs28 gene, polymorphisms at M52L and T140S in the first and third EGF-like domains in comparison to Sal-1 strain were detected, respectively. Six GSGGE tandem repeats followed by GSGGDT or SSGGDT were identified at the end of the fourth EGF-like domain in all Korean isolates. Interestingly, different tandem repeats of amino acid substitutions were observed from isolates collected after 2006 in comparison with preceding years. The ROK isolates revealed limited sequence polymorphisms in pvs25 and tandem repeats in pvs28 in comparison with reported isolates from other nations. Current observations suggested the rapid progresses of genetic changes among Korean isolates. C1 [Jang, Jin Woo; Nam, Myoung Hyun; Lim, Chae Seung] Korea Univ, Coll Med, Dept Lab Med, Seoul 152703, South Korea. [Han, Eun Taek] Kangwon Natl Univ, Coll Med, Dept Parasitol, Chunchon, South Korea. [Lee, Won Ja] KCDC, Natl Inst Hlth, Dept Malaria & Parasite Dis, Seoul, South Korea. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [An, Seong Soo A.] Kyungwon Univ, Gachon Bionano Res Inst, Coll Bionano Technol, Songnam, Kyeonggi Do, South Korea. RP Lim, CS (reprint author), Korea Univ, Guro Hosp, Coll Med, Dept Lab Med, Guro 2 Dong, Seoul 152703, South Korea. EM malarim@korea.ac.kr FU Korean Government [KRF-2008-314-E00075] FX This work was supported by National Research Foundation of Korea Grant funded by the Korean Government (KRF-2008-314-E00075). Disclosure: The view of the authors (Jetsumon Sattabongkot) did not purport to reflect the position of the US Department of the Army or Department of Defense. NR 9 TC 3 Z9 3 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD SEP PY 2010 VL 15 IS 9 BP 1072 EP 1076 DI 10.1111/j.1365-3156.2010.02574.x PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 635NP UT WOS:000280662700012 PM 20545923 ER PT J AU Steele, KE Twenhafel, NA AF Steele, K. E. Twenhafel, N. A. TI Pathology of Animal Models of Alphavirus Encephalitis SO VETERINARY PATHOLOGY LA English DT Review DE alphavirus; EEE; encephalitis; laboratory animals; nervous; VEE; viral; WEE ID VENEZUELAN EQUINE ENCEPHALITIS; VIRUS-INDUCED DISEASE; WESTERN-EQUINE; ENCEPHALOMYELITIS VIRUS; CYNOMOLGUS MACAQUES; EXPERIMENTAL INFECTION; NONHUMAN-PRIMATES; VIRULENCE MARKERS; AEROSOL EXPOSURE; GENE-EXPRESSION AB The encephalitides caused by Venezuelan (VEEV), eastern (EEEV), and western (WEEV) equine encephalitis viruses are important natural diseases of horses and humans and potential agents of biowarfare or bioterrorism. No licensed vaccines or specific therapies exist to prevent or treat human infections with VEEV, EEEV, or WEEV. Well-characterized animal models are needed to support the development of such medical countermeasures under the United States Food and Drug Administration's ''Animal Rule.'' This review focuses on the pathological features and pathogenetic mechanisms of these alphaviral encephalitides in animal models, with an emphasis on aerosol infections. Infection of mice, nonhuman primates, and other species with VEEV, EEEV, and WEEV causes encephalitis and often death. There is great variability in the specific manifestations of disease in the different models, however. Many aspects of the disease in animal models and in humans remain to be characterized using modern methods. Especially needed is a better understanding of the fundamental mechanisms involved in 3 key phases of the pathogenesis of alphavirus encephalitis. These are the early extraneural phase, the process of neuroinvasion itself, and virus and host factors related to neurovirulence. A greater understanding of these aspects could provide avenues for the development of medical countermeasures and better establish suitable animal models of alphavirus encephalitis for testing them under the Animal Rule. C1 [Steele, K. E.] USA, Med Res Inst Infect Dis, Natl Biodef Anal & Countermeasures Ctr, Frederick, MD 21702 USA. RP Steele, KE (reprint author), USA, Med Res Inst Infect Dis, Natl Biodef Anal & Countermeasures Ctr, 110 Thomas Johnson Dr, Frederick, MD 21702 USA. EM steelek@nbacc.net NR 98 TC 48 Z9 52 U1 0 U2 10 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD SEP PY 2010 VL 47 IS 5 BP 790 EP 805 DI 10.1177/0300985810372508 PG 16 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA 675BN UT WOS:000283798900005 PM 20551475 ER PT J AU Twenhafel, NA AF Twenhafel, N. A. TI Pathology of Inhalational Anthrax Animal Models SO VETERINARY PATHOLOGY LA English DT Article DE animal models; anthrax; Bacillus anthracis; biological warfare agent; inhalational anthrax ID EXPERIMENTAL RESPIRATORY ANTHRAX; AEROSOL CHALLENGE MODEL; BACILLUS-ANTHRACIS; LETHAL TOXIN; MURINE MODEL; GUINEA-PIGS; PATHOGENESIS; INFECTION; SPORES; MACROPHAGES AB Anthrax is a lethal disease caused by the bacterium Bacillus anthracis. There are three principal forms of the disease in humans-cutaneous, gastrointestinal, and inhalational-depending on the route of exposure. Of these, inhalational anthrax is the most dangerous; it is rapidly fatal; and it has been used as a deadly biological warfare agent in the last decade. Suitable animal models of inhalational anthrax have been utilized to study pathogenesis of disease, investigate bacterial characteristics such as virulence, and test effectiveness of vaccines and therapeutics. To date, mice, guinea pigs, rabbits, and nonhuman primates are the principal animal species used to study inhalational anthrax. Mice are valuable in studying early pathogenesis and bacterial characteristics. Few pathologic changes occur in the mouse models but may include marked bacteremia and lymphocyte destruction in the spleen and mediastinal lymph nodes. Rabbits and guinea pigs rapidly develop fulminate systemic disease, and pathologic findings often include necrotizing lymphadenitis; splenitis; pneumonia; vasculitis; and hemorrhage, congestion, and edema in multiple tissues. Nonhuman primates consistently develop the full range of classic lesions of human inhalational anthrax, including meningitis; lymphadenitis; splenitis; mediastinitis; pneumonia; vasculitis; and hemorrhage, congestion, and edema in multiple tissues. This review focuses on basic characteristics of the bacterium and its products, key aspects of pathogenesis, and the pathologic changes commonly observed in each animal model species. C1 USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Twenhafel, NA (reprint author), USA, Med Res Inst Infect Dis, Div Pathol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM nancy.twenhafel@us.army.mil NR 67 TC 38 Z9 38 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD SEP PY 2010 VL 47 IS 5 BP 819 EP 830 DI 10.1177/0300985810378112 PG 12 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA 675BN UT WOS:000283798900007 PM 20656900 ER PT J AU Alves, DA Glynn, AR Steele, KE Lackemeyer, MG Garza, NL Buck, JG Mech, C Reed, DS AF Alves, D. A. Glynn, A. R. Steele, K. E. Lackemeyer, M. G. Garza, N. L. Buck, J. G. Mech, C. Reed, D. S. TI Aerosol Exposure to the Angola Strain of Marburg Virus Causes Lethal Viral Hemorrhagic Fever in Cynomolgus Macaques SO VETERINARY PATHOLOGY LA English DT Article DE Marburg virus; aerosol; nonhuman primate; animal model ID FIBROBLASTIC RETICULAR CELLS; HIGH ENDOTHELIAL VENULES; LYMPH-NODE CORTEX; EBOLA-VIRUS; GUINEA-PIGS; NONHUMAN-PRIMATES; DENDRITIC CELLS; RHESUS-MONKEYS; RESTON-VIRUS; MOUSE MODEL AB Cynomolgus macaques were exposed to the Angola strain of Lake Victoria Marburg virus (MARV) by aerosol to examine disease course and lethality. Macaques became febrile 4 to 7 days postexposure; the peak febrile response was delayed 1 to 2 days in animals that received a lower dose; viremia coincided with the onset of fever. All 6 macaques succumbed to the infection, with the 3 macaques in the low-dose group becoming moribund on day 9, a day later than the macaques in the high-dose group. Gross pathologic lesions included maculopapular cutaneous rash; pulmonary congestion and edema; pericardial effusion; enlarged, congested, and/or hemorrhagic lymphoid tissues; enlarged friable fatty liver; and pyloric and duodenal congestion and/or hemorrhage. Fibrinous interstitial pneumonia was the most consistent pulmonary change. Lymphocytolysis and lymphoid depletion, as confirmed by TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling), were observed in the mediastinal lymph nodes and spleen. MARV antigen was detected in the lungs, mediastinal lymph nodes, spleen, and liver of all animals examined. In infected macaques, nuclear expression of interleukin-33 was lost in pulmonary arteriolar and mediastinal lymph node high endothelial venule endothelial cells; interleukin-33-positive fibroblastic reticular cells in the mediastinal lymph node were consistently negative for MARV antigen. These macaques exhibited a number of features similar to those of human filovirus infections; as such, this model of aerosolized MARV-Angola might be useful in developing medical countermeasures under the Animal Rule. C1 [Reed, D. S.] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA 15261 USA. [Alves, D. A.; Glynn, A. R.; Steele, K. E.; Lackemeyer, M. G.; Garza, N. L.; Buck, J. G.; Mech, C.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Reed, DS (reprint author), Univ Pittsburgh, Ctr Vaccine Res, 8037 BST3,3051 5th Ave, Pittsburgh, PA 15261 USA. EM dsreed@cvr.pitt.edu OI Reed, Douglas/0000-0003-0076-9023 FU Defense Threat Reduction Agency [XX0009 06 RD B] FX We acknowledge that this work was supported by funding from the Defense Threat Reduction Agency, Project No. XX0009 06 RD B. NR 94 TC 42 Z9 42 U1 1 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD SEP PY 2010 VL 47 IS 5 BP 831 EP 851 DI 10.1177/0300985810378597 PG 21 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA 675BN UT WOS:000283798900008 PM 20807825 ER PT J AU Chapman, JL Nichols, DK Martinez, MJ Raymond, JW AF Chapman, J. L. Nichols, D. K. Martinez, M. J. Raymond, J. W. TI Animal Models of Orthopoxvirus Infection SO VETERINARY PATHOLOGY LA English DT Article DE Orthopoxvirus; smallpox; monkeypox; cowpox; vaccinia; rabbitpox; laboratory animals ID MONKEYPOX VIRUS-INFECTION; LETHAL MOUSEPOX MODEL; VACCINIA VIRUS; RABBITPOX VIRUS; COWPOX VIRUS; RESPIRATORY-INFECTION; NONHUMAN-PRIMATES; MACACA-IRUS; POX VIRUS; POXVIRUS INFECTIONS AB Smallpox was one of the most devastating diseases known to humanity. Although smallpox was eradicated through a historically successful vaccination campaign, there is concern in the global community that either Variola virus (VARV), the causative agent of smallpox, or another species of Orthopoxvirus could be used as agents of bioterrorism. Therefore, development of countermeasures to Orthopoxvirus infection is a crucial focus in biodefense research, and these efforts rely on the use of various animal models. Smallpox typically presented as a generalized pustular rash with 30 to 40% mortality, and although smallpox-like syndromes can be induced in cynomolgus macaques with VARV, research with this virus is highly restricted; therefore, animal models with other orthopoxviruses have been investigated. Monkeypox virus causes a generalized vesiculopustular rash in rhesus and cynomolgus macaques and induces fatal systemic disease in several rodent species. Ectromelia virus has been extensively studied in mice as a model of orthopoxviral infection in its natural host. Intranasal inoculation of mice with some strains of vaccinia virus produces fatal bronchopneumonia, as does aerosol or intranasal inoculation of mice with cowpox virus. Rabbitpox virus causes pneumonia and fatal systemic infections in rabbits and can be naturally transmitted between rabbits by an aerosol route similar to that of VARV in humans. No single animal model recapitulates all known aspects of human Orthopoxvirus infections, and each model has its advantages and disadvantages. This article provides a brief review of the Orthopoxvirus diseases of humans and the key pathologic features of animal models of Orthopoxvirus infections. C1 [Chapman, J. L.; Nichols, D. K.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Martinez, M. J.] Covance Labs Inc, Vienna, VA USA. [Raymond, J. W.] Armed Forces Inst Pathol, Washington, DC 20306 USA. RP Chapman, JL (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM jennifer.chapman@us.army.mil NR 143 TC 45 Z9 47 U1 0 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD SEP PY 2010 VL 47 IS 5 BP 852 EP 870 DI 10.1177/0300985810378649 PG 19 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA 675BN UT WOS:000283798900009 PM 20682806 ER PT J AU Dobak, WA AF Dobak, William A. TI Class and Race in the Frontier Army: Military Life in the West, 1870-1890 SO WESTERN HISTORICAL QUARTERLY LA English DT Book Review C1 [Dobak, William A.] USA, Ctr Mil Hist, Washington, DC 20310 USA. RP Dobak, WA (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WESTERN HISTORY ASSOC PI LOGAN PA UTAH STATE UNIV, UMC 0740, LOGAN, UT 84322 USA SN 0043-3810 J9 WESTERN HIST QUART JI West. Hist. Q. PD FAL PY 2010 VL 41 IS 3 BP 400 EP 400 PG 1 WC History SC History GA 650TU UT WOS:000281876300037 ER PT J AU Krawczyk, S AF Krawczyk, Scott TI Fellow Romantics: Male and Female British Writers, 1790-1835 SO WORDSWORTH CIRCLE LA English DT Book Review C1 [Krawczyk, Scott] US Mil Acad, West Point, NY 10996 USA. RP Krawczyk, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ED INST BOSTON UNIV PI BOSTON PA 143 BAY STATE RD, RM 212, BOSTON, MA 02215 USA SN 0043-8006 J9 WORDSWORTH CIRCLE JI Wordsworth Circle PD FAL PY 2010 VL 41 IS 4 BP 240 EP 242 PG 3 WC Poetry SC Literature GA 761BV UT WOS:000290370700039 ER PT J AU Lao, YF Pitigala, PKDDP Perera, AGU Liu, HC Buchanan, M Wasilewski, ZR Choi, KK Wijewarnasuriya, P AF Lao, Y. F. Pitigala, P. K. D. D. P. Perera, A. G. U. Liu, H. C. Buchanan, M. Wasilewski, Z. R. Choi, K. K. Wijewarnasuriya, P. TI Light-hole and heavy-hole transitions for high-temperature long-wavelength infrared detection SO APPLIED PHYSICS LETTERS LA English DT Article ID GAAS AB Hole transitions from the heavy-hole (hh) to the light-hole (lh) band contributing to the 4-10 mu m response range are reported on p-GaAs/ AlGaAs detectors. The detectors show a spectral response up to 16.5 mu m, operating up to a temperature of 330 K where the lh-hh response is superimposed on the free-carrier response. Two characteristic peaks observed between 5-7 mu m are in good agreement with corresponding energy separations of the lh and hh bands and thus originated from lh-hh transitions. Results will be useful for designing multi-spectral detection which could be realized on a single p-GaAs structure. (C) 2010 American Institute of Physics. [doi:10.1063/1.3486169] C1 [Lao, Y. F.; Pitigala, P. K. D. D. P.; Perera, A. G. U.] Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. [Liu, H. C.; Buchanan, M.; Wasilewski, Z. R.] Natl Res Council Canada, Inst Microstruct Sci, Ottawa, ON K1A 0R6, Canada. [Choi, K. K.; Wijewarnasuriya, P.] USA, Res Lab, Adelphi, MD 20783 USA. RP Lao, YF (reprint author), Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. EM uperera@gsu.edu RI Lao, Yanfeng/D-5450-2011; Lao, Yanfeng/C-1468-2012; Lao, Yanfeng/D-2908-2012; Choi, Kwong-Kit/K-9205-2013; OI Pitigala, P K D Duleepa/0000-0003-4824-0188; Lao, Yanfeng/0000-0002-6301-9417 FU U.S. Army Research Office [W911NF-08-1-0448]; U.S. National Science Foundation [ECS-0553051] FX This work was supported in part by the U.S. Army Research Office under Grant No. W911NF-08-1-0448 monitored by Dr. William W. Clark, and in part by the U.S. National Science Foundation under Grant No. ECS-0553051. Authors acknowledge Greggory Rothmeier for help in manuscript preparation. NR 13 TC 25 Z9 25 U1 1 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 30 PY 2010 VL 97 IS 9 AR 091104 DI 10.1063/1.3486169 PG 3 WC Physics, Applied SC Physics GA 654SB UT WOS:000282187200004 ER PT J AU Geis, MW Lyszczarz, TM Osgood, RM Kimball, BR AF Geis, M. W. Lyszczarz, T. M. Osgood, R. M. Kimball, B. R. TI 30 to 50 ns liquid-crystal optical switches SO OPTICS EXPRESS LA English DT Article ID ORDER-PARAMETER; UNIVERSALITY AB The optical switching time of twisted-nematic liquid-crystal cells using the liquid crystals, 5CB (C5H11-Ph-Ph-CN), 5OCB(C5H11-O-Ph-Ph-CN) and PCH5 (C5H11-Cy-Ph-CN) have been characterized as a function of temperature, bias voltage and switching voltage, V. The transition time from 90% to 10% transmission scales as V-1.9 and is limited to 30 to 50 ns by the liquid-crystal breakdown electric field, similar to 100 V mu m(-1). The time from the initial switching voltage step to 90% transmission, delay time, decreases with increasing bias and switching voltage. For 5CB and 5OCB the delay time approaches a constant value at higher electric fields, > 10 V mu m(-1). Both the transition and delay times decrease with increasing temperature. The minimum transition time at temperatures a few degrees below the nematic-isotropic temperature are 32, 32, and 44 ns and delay times are 44, 25 and 8 ns for 5CB, 5OCB, and PCH5 respectively. (C) 2010 Optical Society of America C1 [Geis, M. W.; Lyszczarz, T. M.] MIT, Lincoln Lab, Lexington, MA 02420 USA. [Osgood, R. M.; Kimball, B. R.] Ctr Dev & Engn, Natick Lab Army Res, Natick, MA 01760 USA. RP Geis, MW (reprint author), MIT, Lincoln Lab, Lexington, MA 02420 USA. EM geis@ll.mit.edu FU U. S. Army Natick Soldiers Research Development and Engineering Center under Air Force [FA8721-05-C-0002] FX The authors are grateful to Oleg D. Lavrentovich, Noel Clark, Hugh Wonderly and Germano S. Iannacchione for helpful discussions, and to S. Deneault, M. Marchant and K. Krohn for expert technical assistance. The Lincoln Laboratory portion of this work was sponsored by the U. S. Army Natick Soldiers Research Development and Engineering Center under Air Force Contract FA8721-05-C-0002. Opinions, interpretations, conclusions, and recommendations are those of the authors and do not necessarily represent the view of the United States Government. NR 15 TC 7 Z9 7 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD AUG 30 PY 2010 VL 18 IS 18 BP 18886 EP 18893 DI 10.1364/OE.18.018886 PG 8 WC Optics SC Optics GA 653PE UT WOS:000282107900040 PM 20940781 ER PT J AU Houng, HSH Gong, HP Kajon, AE Jones, MS Kuschner, RA Lyons, A Lott, L Lin, KH Metzgar, D AF Houng, Huo-Shu H. Gong, Heping Kajon, Adriana E. Jones, Morris S. Kuschner, Robert A. Lyons, Arthur Lott, Lisa Lin, Kuei-Hsiang Metzgar, David TI Genome sequences of Human Adenovirus 14 isolates from mild respiratory cases and a fatal pneumonia, isolated during 2006-2007 epidemics in North America SO RESPIRATORY RESEARCH LA English DT Article ID MILITARY RECRUITS; INFECTIONS; DISEASE; TYPE-7; ILLNESS; SEROTYPES; EVOLUTION; CHILDREN; TAIWAN; CAMP AB Background: Human adenovirus 14 (HAdV-14) is a recognized causative agent of epidemic febrile respiratory illness (FRI). Last reported in Eurasia in 1963, this virus has since been conspicuously absent in broad surveys, and was never isolated in North America despite inclusion of specific tests for this serotype in surveillance methods. In 2006 and 2007, this virus suddenly emerged in North America, causing high attack rate epidemics of FRI and, in some cases, severe pneumonias and occasional fatalities. Some outbreaks have been relatively mild, with low rates of progression beyond uncomplicated FRI, while other outbreaks have involved high rates of more serious outcomes. Methodology and Findings: In this paper we present the complete genomic sequence of this emerging pathogen, and compare genomic sequences of isolates from both mild and severe outbreaks. We also compare the genome sequences of the recent isolates with those of the prototype HAdV-14 that circulated in Eurasia 30 years ago and the closely related sequence of HAdV-11a, which has been circulating in southeast Asia. Conclusions: The data suggest that the currently circulating strain of HAdV-14 is closely related to the historically recognized prototype throughout its genome, though it does display a couple of potentially functional mutations in the fiber knob and E1A genes. There are no polymorphisms that suggest an obvious explanation for the divergence in severity between outbreak events, suggesting that differences in outcome are more likely environmental or host determined rather than viral genetics. C1 [Houng, Huo-Shu H.; Gong, Heping; Kuschner, Robert A.; Lyons, Arthur] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Kajon, Adriana E.] Lovelace Resp Res Inst, Program Infect Dis, Albuquerque, NM 87108 USA. [Jones, Morris S.] David Grant USAF Med Ctr DGMC, Clin Invest Facil, Travis AFB, CA 94535 USA. [Lott, Lisa] Off AF Surg Gen, Adv Diagnost Lab, Lackland AFB, TX 78236 USA. [Lin, Kuei-Hsiang] Kaohsiung Med Univ, Dept Clin Lab, Kaohsiung 80708, Taiwan. [Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92106 USA. RP Houng, HSH (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM huo-shu.houng@amedd.army.mil RI Lyons, Arthur/B-8923-2011; Valle, Ruben/A-7512-2013 NR 40 TC 17 Z9 17 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1465-9921 J9 RESP RES JI Respir. Res. PD AUG 25 PY 2010 VL 11 AR 116 DI 10.1186/1465-9921-11-116 PG 8 WC Respiratory System SC Respiratory System GA 659FP UT WOS:000282552700001 PM 20738863 ER PT J AU Tonelli, AE Jhon, YK Genzer, J AF Tonelli, Alan E. Jhon, Young K. Genzer, Jan TI Glass Transition Temperatures of Styrene/4-BrStyrene Copolymers with Variable Co-Monomer Compositions and Sequence Distributions SO MACROMOLECULES LA English DT Article C1 [Tonelli, Alan E.] N Carolina State Univ, Fiber & Polymer Sci Program, Raleigh, NC 27695 USA. [Jhon, Young K.] USA, Div Chem Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Tonelli, AE (reprint author), N Carolina State Univ, Fiber & Polymer Sci Program, Campus Box 8301, Raleigh, NC 27695 USA. EM alan_tonelli@ncsu.edu FU National Science Foundation [DMR-0353102, OISE-0730243]; National Research Council at the Army Research Office FX We are grateful to the diligent reviewers of this work. Y.K.J. and J.G. thank the National Science Foundation for support under contracts DMR-0353102 and OISE-0730243 and Y.K.J. thanks the National Research Council Research Associateship Award at the Army Research Office. NR 15 TC 3 Z9 3 U1 1 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD AUG 24 PY 2010 VL 43 IS 16 BP 6912 EP 6914 DI 10.1021/ma101355f PG 3 WC Polymer Science SC Polymer Science GA 637YQ UT WOS:000280855000047 ER PT J AU Sedegah, M Kim, Y Peters, B McGrath, S Ganeshan, H Lejano, J Abot, E Banania, G Belmonte, M Sayo, R Farooq, F Doolan, DL Regis, D Tamminga, C Chuang, I Bruder, JT King, CR Ockenhouse, CF Faber, B Remarque, E Hollingdale, MR Richie, TL Sette, A AF Sedegah, Martha Kim, Yohan Peters, Bjoern McGrath, Shannon Ganeshan, Harini Lejano, Jennylynn Abot, Esteban Banania, Glenna Belmonte, Maria Sayo, Renato Farooq, Fouzia Doolan, Denise L. Regis, David Tamminga, Cindy Chuang, Ilin Bruder, Joseph T. King, C. Richter Ockenhouse, Christian F. Faber, Bart Remarque, Edmond Hollingdale, Michael R. Richie, Thomas L. Sette, Alessandro TI Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein SO MALARIA JOURNAL LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; MALARIA VACCINE CANDIDATE; NATURAL IMMUNE-RESPONSES; BLOOD-STAGE VACCINE; BAY COHORT PROJECT; CLASS-I SUPERTYPES; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE ANTIGEN; GENETIC DIVERSITY; CLINICAL-TRIAL AB Background: Plasmodium falciparum apical membrane antigen-1 (AMA1) is a leading malaria vaccine candidate antigen that is expressed by sporozoite, liver and blood stage parasites. Since CD8+ T cell responses have been implicated in protection against pre-erythrocytic stage malaria, this study was designed to identify MHC class I-restricted epitopes within AMA1. Methods: A recombinant adenovirus serotype 5 vector expressing P. falciparum AMA1 was highly immunogenic when administered to healthy, malaria-naive adult volunteers as determined by IFN-gamma ELISpot responses to peptide pools containing overlapping 15-mer peptides spanning full-length AMA1. Computerized algorithms (NetMHC software) were used to predict minimal MHC-restricted 8-10-mer epitope sequences within AMA1 15-mer peptides active in ELISpot. A subset of epitopes was synthesized and tested for induction of CD8+ T cell IFN-gamma responses by ELISpot depletion and ICS assays. A 3-dimensional model combining Domains I + II of P. falciparum AMA1 and Domain III of P. vivax AMA1 was used to map these epitopes. Results: Fourteen 8-10-mer epitopes were predicted to bind to HLA supertypes A01 (3 epitopes), A02 (4 epitopes), B08 (2 epitopes) and B44 (5 epitopes). Nine of the 14 predicted epitopes were recognized in ELISpot or ELISpot and ICS assays by one or more volunteers. Depletion of T cell subsets confirmed that these epitopes were CD8+ T cell-dependent. A mixture of the 14 minimal epitopes was capable of recalling CD8+ T cell IFN-gamma responses from PBMC of immunized volunteers. Thirteen of the 14 predicted epitopes were polymorphic and the majority localized to the more conserved front surface of the AMA1 model structure. Conclusions: This study predicted 14 and confirmed nine MHC class I-restricted CD8+ T cell epitopes on AMA1 recognized in the context of seven HLA alleles. These HLA alleles belong to four HLA supertypes that have a phenotypic frequency between 23% - 100% in different human populations. C1 [Sedegah, Martha; Ganeshan, Harini; Lejano, Jennylynn; Abot, Esteban; Banania, Glenna; Belmonte, Maria; Sayo, Renato; Farooq, Fouzia; Regis, David; Tamminga, Cindy; Chuang, Ilin; Richie, Thomas L.] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Silver Spring, MD 20910 USA. [Kim, Yohan; Peters, Bjoern; Sette, Alessandro] La Jolla Inst Allergy & Immunol, La Jolla, CA USA. [McGrath, Shannon; Ockenhouse, Christian F.] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA. [Ganeshan, Harini; Lejano, Jennylynn; Abot, Esteban; Banania, Glenna; Belmonte, Maria; Sayo, Renato; Farooq, Fouzia] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20852 USA. [Doolan, Denise L.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Bruder, Joseph T.; King, C. Richter] GenVec, Gaithersburg, MD 20878 USA. [Faber, Bart; Remarque, Edmond] Biomed Primate Res Ctr, Rijswijk, Netherlands. [Hollingdale, Michael R.] NMRC, Malaria Dept, USMMVP, Silver Spring, MD 20910 USA. RP Hollingdale, MR (reprint author), NMRC, Malaria Dept, USMMVP, Silver Spring, MD 20910 USA. EM mikedc110@gmail.com RI Belmonte, Maria/A-8032-2011; Doolan, Denise/F-1969-2015; OI Richie, Thomas/0000-0002-2946-5456 FU USAID; Military Infectious Diseases Research Program; Congressionally Directed Medical Research Program; Pfizer; [6000.RAD1.F.A0309] FX The authors thankfully acknowledge Henk van Westbroek who created Figure 5. DR, CT, IC, CFO and TLR are active duty military personnel at the time they contributed to this work; MS is a US Government employee. The work of these individuals was prepared as part of official government duties. Title 17 U.S.C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U.S.C. 101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. The work of authors affiliated with the Naval Medical Research Center was supported by work unit number 6000.RAD1.F.A0309. Major funding for this work was provided by USAID, the Military Infectious Diseases Research Program, and the Congressionally Directed Medical Research Program. DLD was supported by a Pfizer Australia Senior Research Fellowship. The study protocol for the clinical trial presented in this manuscript was approved by the National Naval Medical Center, Naval Medical Research Center and Walter Reed Army Institute of Research Institutional Review Boards, in compliance with all applicable Federal regulations governing protection of human subjects. All study subjects gave written informed consent. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of the Army, the Department of Defense, or the U. S. Government. NR 70 TC 10 Z9 10 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD AUG 24 PY 2010 VL 9 AR 241 DI 10.1186/1475-2875-9-241 PG 16 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 657MM UT WOS:000282416800001 PM 20735847 ER PT J AU Blagborough, AM Yoshida, S Sattabongkot, J Tsuboi, T Sinden, RE AF Blagborough, Andrew M. Yoshida, Shigeto Sattabongkot, Jetsumon Tsuboi, Takafumi Sinden, Robert E. TI Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission SO VACCINE LA English DT Article DE Malaria; Plasmodium vivax; Baculovirus; Transgenic ID CHOLERA-TOXIN; MALARIA; MICE; ANTIBODIES; BERGHEI; PFS25; IMMUNITY; IMMUNOGENICITY; CANDIDATES; PROTECTION AB We have recently developed a new experimental vaccine vector system based on Autographa californica nucleopolyhedrosis virus (AcNPV) termed the "Baculovirus Dual Expression System", which drives expression of vaccine candidate antigens by a dual promoter that consists of tandemly arranged baculovirus-derived polyhedrin and mammalian-derived CMV promoters. The present study used this system to generate a Plasmodium vivax transmission-blocking immunogen (AcNPV-Dual-Pvs25). AcNPV-Dual-Pvs25 not only displayed Pvs25 on the AcNPV envelope, exhibiting aspects of its native three-dimensional structure, but also expressed appropriately immunogenic protein upon transduction of mammalian cells. Both intranasal and intramuscular immunization of mice with AcNPV-Dual-Pvs25 induced high Pvs25-specific antibody titres, notably of IgG1, IgG2a and IgG2b isotypes, indicating a mixed Thl/Th2 response. Importantly, sera obtained from subcutaneously immunized rabbits exhibited a significant transmission-blocking effect (96% reduction in infection intensity, 24% reduction in prevalence) when challenged with human blood infected with P. vivax gametocytes using the standard membrane feeding assay. Additionally, active immunization (both intranasal and intramuscular routes) of mice followed by challenge using a transgenic P. berghei line expressing Pvs25 in place of native Pbs25 and Pbs28 (clone Pv525DR3) demonstrates a strong transmission-blocking response, with a 92.1% (intranasal) and 83.8% (intramuscular) reduction in oocyst intensity. Corresponding reductions in prevalence of infection were observed (88.4% and 75.5% respectively). This study offers a novel tool for the development of malarial transmission-blocking vaccines against the sexual stages of the parasite, using the Baculovirus Dual Expression System that functions as both a subunit, and DNA based vaccine. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Blagborough, Andrew M.; Sinden, Robert E.] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Div Cell & Mol Biol, London SW7 2AZ, England. [Yoshida, Shigeto] Jichi Med Univ, Dept Infect & Immun, Div Med Zool, Shimotsuke, Tochigi 3290498, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. RP Blagborough, AM (reprint author), Imperial Coll Rd, London SW7 2AZ, England. EM andrew.blagborough@imperial.ac.uk; shigeto@jichi.ac.jp FU Ministry of Education, Culture, Sports and Science of Japan [21390126]; Biomalpar, Transmolbloc; BBSRC [LDAD_P15820] FX We would like to thank Hitomi Araki for excellent assistance with the ELISAs and handling of the mice. We also thank Ken Baker and Mark Tunnicliff for mosquito rearing (Imperial College, London). This work was supported by grants from the Ministry of Education, Culture, Sports and Science of Japan (21390126) (Jichi Medical University), and Biomalpar, Transmolbloc and BBSRC (award number LDAD_P15820) (Imperial College, London). NR 30 TC 25 Z9 26 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 23 PY 2010 VL 28 IS 37 BP 6014 EP 6020 DI 10.1016/j.vaccine.2010.06.100 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 647OF UT WOS:000281627100014 PM 20637303 ER PT J AU Tribble, D Kaminski, R Cantrell, J Nelson, M Porter, C Baqar, S Williams, C Arora, R Saunders, J Ananthakrishnan, M Sanders, J Zaucha, G Turbyfill, R Oaks, E AF Tribble, D. Kaminski, R. Cantrell, J. Nelson, M. Porter, C. Baqar, S. Williams, C. Arora, R. Saunders, J. Ananthakrishnan, M. Sanders, J. Zaucha, G. Turbyfill, R. Oaks, E. TI Safety and immunogenicity of a Shigella flexneri 2a Invaplex 50 intranasal vaccine in adult volunteers SO VACCINE LA English DT Article DE Shigella flexneri; Invaplex; Nasal vaccine ID INVASIN COMPLEX; IMMUNE-RESPONSE; INFECTION; EFFICACY; DIARRHEA; MODEL; LIVE; LIPOPOLYSACCHARIDE; OPTIMIZATION; PATHOGENESIS AB Shigellosis is a leading cause of diarrhea worldwide prompting vaccine development. The Shigella flexneri Invaplex 50 is a macromolecular complex containing IpaB, IpaC, and LPS, formulated from an aqueous extract of virulent Shigella delivered via nasal administration. Preclinical vaccine testing demonstrated safety, immunogenicity and efficacy. An open-label dose-escalating phase 1 study evaluated a 3-dose (2-week intervals) regimen via nasal pipette delivery. Thirty-two subjects were enrolled into one of four vaccine dose groups (10, 50,240, or 480 mu g). The vaccine was well tolerated with minor short-lived nasal symptoms without evidence of dose effect. Antibody-secreting cell (ASC) responses were elicited at doses >= 50 mu g with the highest IgG ASC, Invaplex 50 (100%) and S. flexneri 2a LPS (71%), as well as, serologic responses (43%) occurring with the 240 mu g dose. Fecal IgA responses, Invaplex 50(38.5%) and LPS (30.8%), were observed at doses >= 240 mu g. The Invaplex 50 nasal vaccine was safe with encouraging mucosal immune responses. Follow-on studies will optimize dose, delivery mechanism and assess efficacy in a S. flexneri 2a challenge study. Published by Elsevier Ltd. C1 [Tribble, D.; Cantrell, J.; Porter, C.; Baqar, S.; Williams, C.] USN, Med Res Ctr, Silver Spring, MD USA. [Kaminski, R.; Saunders, J.; Ananthakrishnan, M.; Zaucha, G.; Turbyfill, R.; Oaks, E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Nelson, M.; Arora, R.] Walter Reed Army Med Ctr, Washington, DC USA. [Saunders, J.] Natl Naval Med Ctr, Bethesda, MD USA. RP Tribble, D (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Prevent Med & Biometr Dept, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM dtribble@usuhs.mil FU Work Unit [643807A.849.D.A0002.] FX This work was supported by Work Unit Number 643807A.849.D.A0002. NR 42 TC 13 Z9 15 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 23 PY 2010 VL 28 IS 37 BP 6076 EP 6085 DI 10.1016/j.vaccine.2010.06.086 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 647OF UT WOS:000281627100022 PM 20619378 ER PT J AU Andzelm, J Rinderspacher, C Lambeth, R Rawlett, A AF Andzelm, Jan Rinderspacher, Christopher Lambeth, Robert Rawlett, Adam TI Modeling of energy dissipation in supramolecular polymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Andzelm, Jan; Rinderspacher, Christopher; Lambeth, Robert; Rawlett, Adam] USA, Macromol Sci & Technol Branch, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 324-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164706512 ER PT J AU Berg, MC Mrozek, RA Strawhecker, K Andzelm, J Chantawansri, T Sliozberg, Y Lenhart, JL AF Berg, Michael C. Mrozek, Randy A. Strawhecker, Kenneth Andzelm, Jan Chantawansri, Tanya Sliozberg, Yelena Lenhart, Joseph L. TI Modification of thermoplastic elastomer gels through nanoparticle addition SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Berg, Michael C.; Mrozek, Randy A.; Strawhecker, Kenneth; Andzelm, Jan; Chantawansri, Tanya; Sliozberg, Yelena; Lenhart, Joseph L.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RI Chantawansri, Tanya/N-3601-2013 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 434-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164707029 ER PT J AU Boddu, VM Maloney, SW Viswanath, DS Ghoash, TK Uchimiya, SM AF Boddu, Veera M. Maloney, Stephen W. Viswanath, Dabir S. Ghoash, Tushar K. Uchimiya, Sophie M. TI Evaluation of chitosan coated granular activated carbon for treatment of perchlorate-contaminated munitions wastewater SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 Engn Res & Dev Ctr ERDC CERL, Environm Proc Branch, Champaign, IL USA. Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO USA. ARS, USDA, New Orleans, LA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 312-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164702691 ER PT J AU Bukowski, EJ Jestel, EA AF Bukowski, Eric J. Jestel, E. Alex TI Evaluation of GCxGC-TOF-MS as an advanced screening technique in support of the Organization for the Prohibition of Chemical Weapons (OPCW) proficiency testing SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 Sci & Technol Corp, Edgewood, MD USA. USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 190-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164700342 ER PT J AU Daita, K Tripathy, S Nagarajan, S Nagarajan, R Bruno, FF Samuelson, L Kumar, J AF Daita, Kalyani Tripathy, Sheila Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Bruno, Ferdinando F. Samuelson, Lynne Kumar, Jayant TI Biocatalytically polymerized flavonoids with enhanced antioxidant activity SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 Univ Massachusetts, Ctr Adv Mat, Lowell, MA USA. USA, Res Dev & Engn Ctr, Natick Soldier RDECOM, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 153-AGFD PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164700111 ER PT J AU Filocamo, S Stote, R AF Filocamo, Shaun Stote, Robert TI Morphological control over Titanium Oxide precipitates using a biomimetic approach SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Filocamo, Shaun; Stote, Robert] USA, NSRDEC, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 161-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164701644 ER PT J AU Jestel, EA Bukowski, EJ Rusek, TF AF Jestel, E. Alex Bukowski, Eric J. Rusek, Thomas F. TI Maximizing chromatographic information obtained from complex improvised explosive device (IED) field samples by high-throughput GCxGC-TOF-MS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD USA. Sci & Technol Corp, Aberdeen Proving Ground, MD USA. Battelle Mem Inst, Aberdeen, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 225-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164700376 ER PT J AU Labare, MP Labare, M Takacs, L Butler, H Yess, E Butler, C Riegner, DE AF Labare, Michael P. Labare, Michaela Takacs, Lindsey Butler, Honour Yess, Elaina Butler, Cora Riegner, Dawn E. TI Antibiotic resistance in bacteria from antibiotic-free poultry flocks SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. Anim World, New Palz, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 163-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164701191 ER PT J AU Leadore, JL Orlicki, JA Strawhecker, KE AF Leadore, Julia L. Orlicki, Joshua A. Strawhecker, Kenneth E. TI Characterization of bio-inspired functionally-graded materials prepared using photopolymerization SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Leadore, Julia L.; Orlicki, Joshua A.; Strawhecker, Kenneth E.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 114-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164706319 ER PT J AU Lenhart, JL Mrozek, R Berg, M Andzelm, J Sliozberg, Y Shull, KR Otim, K AF Lenhart, Joseph L. Mrozek, Randy Berg, Michael Andzelm, Jan Sliozberg, Yelena Shull, Kenneth R. Otim, Katie TI Hierarchically structured polymer composites: Broadly enabling multifunctional materials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD USA. Northwestern Univ, Evanston, IL USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 185-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164706381 ER PT J AU Li, D Chen, C Johnson, DR Alvarez, PJJ AF Li, Dong Chen, Chun Johnson, David R. Alvarez, Pedro J. J. TI Bioaccumulation of C-14(60) by the earthworm Eisenia foetida SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 Rice Univ, Dept Civil & Environm Engn, Houston, TX USA. Nankai Univ, Coll Environm Sci & Engn, Tianjin 300071, Peoples R China. USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 160-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164702553 ER PT J AU Mao, JD Pignatello, JJ Lehmann, J Chappell, M AF Mao, Jingdong Pignatello, Joseph J. Lehmann, Johannes Chappell, Mark TI Characterization of charcoal using advanced solid-state NMR SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA USA. Connecticut Agr Expt Stn, New Haven, CT 06504 USA. USA, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. Cornell Univ, Dept Crop & Soil Sci, Ithaca, NY USA. RI Lehmann, Johannes/H-2682-2014 OI Lehmann, Johannes/0000-0002-4701-2936 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 167-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164702560 ER PT J AU Mrozek, RA Cole, PJ Lenhart, JL Berg, MC Shull, KR Otim, KJ AF Mrozek, Randy A. Cole, Phillip J. Lenhart, Joseph L. Berg, Michael C. Shull, Kenneth R. Otim, Kathryn J. TI Impact of sol molecular weight on the mechanical properties and fracture behavior of elastomeric polysiloxanes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA, Army Res Lab, Aberdeen, MD USA. Sandia Natl Labs, Albuquerque, NM 87185 USA. Northwestern Univ, Evanston, IL USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 352-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164706532 ER PT J AU Orlicki, JA Williams, AA Zander, NE Kosik, WE Martin, GR Levine, F Escarsega, J Farrell, A Rawlett, AM AF Orlicki, Joshua A. Williams, Andre A. Zander, Nicole E. Kosik, Wendy E. Martin, George R. Levine, Felicia Escarsega, John Farrell, Alicia Rawlett, Adam M. TI Nanomaterial enabled performance enhancements for Army coating and composite systems SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Orlicki, Joshua A.; Williams, Andre A.; Zander, Nicole E.; Kosik, Wendy E.; Martin, George R.; Levine, Felicia; Escarsega, John; Farrell, Alicia; Rawlett, Adam M.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 187-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164706383 ER PT J AU Schoch, AB Fischer, DA Lenhart, JL AF Schoch, Andrew B. Fischer, Daniel A. Lenhart, Joseph L. TI NEXAFS characterization and mechanical testing of engineered epoxy/substrate interfaces SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA, Res Lab, Aberdeen Proving Ground, MD USA. NIST, Div Ceram, Synchrotron Methods Grp, Gaithersburg, MD 20899 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 348-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164706527 ER PT J AU Stokes, KK Berg, MC Beyer, FL Lenhart, JL AF Stokes, Kristoffer K. Berg, Michael C. Beyer, Frederick L. Lenhart, Joseph L. TI Strategies for loading nanocomposite materials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Stokes, Kristoffer K.; Berg, Michael C.; Beyer, Frederick L.; Lenhart, Joseph L.] USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 204-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164706396 ER PT J AU Tokarz, JA Ginter, JM Ostazeski, SA AF Tokarz, John A. Ginter, Joy M. Ostazeski, Stanley A. TI Characterization of homemade explosives (HMEs) by ion chromatography - tandem mass spectrometry (IC-MS/MS) SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 [Tokarz, John A.; Ginter, Joy M.; Ostazeski, Stanley A.] USA, ECBC, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 183-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164700334 ER PT J AU Zander, NE Orlicki, JA Rawlett, AM Beebe, TP AF Zander, Nicole E. Orlicki, Joshua A. Rawlett, Adam M. Beebe, Thomas P. TI Surface-modified electrospun fibers for the enhancement and control of neurite outgrowth SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen Proving Ground, MD USA. Univ Delaware, Newark, DE USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 2010 VL 240 MA 256-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA V20UK UT WOS:000208164706748 ER PT J AU Dong, LB McVicker, GB Kiserow, DJ Roberts, GW AF Dong, Laura Beth McVicker, Gary B. Kiserow, Douglas J. Roberts, George W. TI Hydrogenation of polystyrene in CO2-expanded liquids: The effect of catalyst composition on deactivation SO APPLIED CATALYSIS A-GENERAL LA English DT Article DE Polystyrene; Carbon dioxide-expanded liquid; Reverse water-gas shift reaction; Hydrogenation; Catalyst deactivation ID SUPERCRITICAL CARBON-DIOXIDE; CO2; COPOLYMERS; SOLVENTS; FLUIDS AB The effect of catalyst composition on the hydrogenation of the aromatic rings of polystyrene dissolved in carbon dioxide-expanded decahydronaphthalene (CO2-DHN) was studied using a slurry reactor at 150 C. Catalyst deactivation occurred within 15 min of the addition of CO2 to the reactor when 5% Pd/SiO2 or 5% Pd/Al2O3 was used as the catalyst. The deactivation is believed to be a consequence of CO formation via the reverse water-gas shift reaction, as CO was observed at the end of each hydrogenation reaction. In an effort to convert CO to CH4 before the poisoning of Pd sites occurred, a methanation catalyst such as 5% Ru/Al2O3 or 65% Ni/SiO2-Al2O3 was physically mixed with 5% Pd/SiO2 or 5% Pd/Al2O3 and used to hydrogenate PS. Carbon monoxide concentrations decreased, but no significant improvements in aromatic ring hydrogenation were observed. When a catalyst containing both a hydrogenation and methanation function in a single catalyst particle (1.6% Ru/4.2% Pd/SiO2) was used, the degrees of hydrogenation in CO2-DHN matched those obtained when neat DHN was the solvent. Furthermore, no CO was detected when the reaction was catalyzed by the bimetallic catalyst. These results suggest that the methanation function must be proximate to the hydrogenation (reverse water-gas shift) function in order for aromatic ring hydrogenation to proceed as rapidly in a CO2-expanded solvent as in the unexpanded solvent. (C) 2010 Elsevier BM. All rights reserved. C1 [Dong, Laura Beth; McVicker, Gary B.; Kiserow, Douglas J.; Roberts, George W.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Kiserow, Douglas J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Dong, LB (reprint author), Albemarle Corp, Baton Rouge, LA USA. EM laura.beth.dong@albemarle.com FU United States Army Research Office, Research Triangle Park, [W911NF-04-D-0003]; National Science Foundation [CHE-9876674] FX This research was supported by Contract W911NF-04-D-0003 from the United States Army Research Office, Research Triangle Park, NC. Partial support was also provided by the SIC Program of the National Science Foundation under Agreement No. CHE-9876674. This material is also based upon work supported under a National Science Foundation Graduate Research Fellowship (LBD). The authors also thank Dr. Wayne P. Robarge (Department of Soil Science, North Carolina State University) for the ICP measurements. NR 34 TC 4 Z9 5 U1 0 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-860X J9 APPL CATAL A-GEN JI Appl. Catal. A-Gen. PD AUG 20 PY 2010 VL 384 IS 1-2 BP 45 EP 50 DI 10.1016/j.apcata.2010.06.004 PG 6 WC Chemistry, Physical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA 642CA UT WOS:000281179700006 ER PT J AU Mehmood, A Nasrabadi, NM AF Mehmood, Asif Nasrabadi, Nasser M. TI Wavelet-RX anomaly detection for dual-band forward-looking infrared imagery SO APPLIED OPTICS LA English DT Article ID AUTOMATIC TARGET RECOGNITION; HYPERSPECTRAL IMAGERY; TRANSFORM; ALGORITHMS; BASES AB This paper describes a new wavelet-based anomaly detection technique for a dual-band forward-looking infrared (FLIR) sensor consisting of a coregistered longwave (LW) with a midwave (MW) sensor. The proposed approach, called the wavelet-RX (Reed-Xiaoli) algorithm, consists of a combination of a two-dimensional (2D) wavelet transform and a well-known multivariate anomaly detector called the RX algorithm. In our wavelet-RX algorithm, a 2D wavelet transform is first applied to decompose the input image into uniform subbands. A subband-image cube is formed by concatenating together a number of significant subbands (high-energy subbands). The RX algorithm is then applied to the subband-image cube obtained from a wavelet decomposition of the LW or MW sensor data. In the case of the dual band, the RX algorithm is applied to a subband-image cube constructed by concatenating together the high-energy subbands of the LW and MW subband-image cubes. Experimental results are presented for the proposed wavelet-RX and the classical constant false alarm rate (CFAR) algorithm for detecting anomalies (targets) in a single broadband FLIR (LW or MW) or in a coregistered dual-band FLIR sensor. The results show that the proposed wavelet-RX algorithm outperforms the classical CFAR detector for both single-band and dual-band FLIR sensors. (C) 2010 Optical Society of America C1 [Mehmood, Asif; Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Mehmood, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM asif.mehmood1@us.army.mil NR 27 TC 3 Z9 3 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD AUG 20 PY 2010 VL 49 IS 24 BP 4621 EP 4632 DI 10.1364/AO.49.004621 PG 12 WC Optics SC Optics GA 642FB UT WOS:000281188300019 PM 20733634 ER PT J AU Shukla, MK Dubey, M Zakar, E Namburu, R Leszczynski, J AF Shukla, Manoj K. Dubey, Madan Zakar, Eugene Namburu, Raju Leszczynski, Jerzy TI Density functional theory investigation of interaction of zigzag (7,0) single-walled carbon nanotube with Watson-Crick DNA base pairs SO CHEMICAL PHYSICS LETTERS LA English DT Article ID NUCLEIC-ACID BASES; RAMAN-SPECTROSCOPY AB A first-principles investigation of interaction of DNA base pairs on the outer surface of zigzag (7,0) single-walled carbon nanotube (CNT) was carried out at the M05-2X/6-31G(d) level of geometry optimization and BSSE corrected interaction energy calculation using the same theoretical level and the 6311G(d,p), cc-pVDZ and cc-pVTZ basis sets. Study revealed that CNT forms complexes of similar strength with both base pairs. Electron density maps suggest that complexes are characterized by stacking interaction through coupling of pi-charge clouds of base pairs and CNT. BSSE corrected interaction energies and density of states calculations indicated the weak nature of interaction between base pairs and CNT. (C) 2010 Elsevier B.V. All rights reserved. C1 [Shukla, Manoj K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Dubey, Madan; Zakar, Eugene] USA, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Namburu, Raju] USA, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD 20783 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU Army Research Laboratory [W911QX-07-C-0100]; NSF-EPSCoR [362492-190200-01/NSFEPS-0903787] FX M.K.S. and J.L. are thankful to supports from Army Research Laboratory Contract Number W911QX-07-C-0100 and NSF-EPSCoR Grant Nos. 362492-190200-01/NSFEPS-0903787. Authors are also thankful to ARL. Computational and Information Sciences Directorate Adelphi, MD 20783, USA for providing computational facility. NR 22 TC 15 Z9 15 U1 0 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 EI 1873-4448 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD AUG 20 PY 2010 VL 496 IS 1-3 BP 128 EP 132 DI 10.1016/j.cplett.2010.07.042 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 643LC UT WOS:000281296900026 ER PT J AU Lentine, KL Schnitzler, MA Xiao, HL Saab, G Salvalaggio, PR Axelrod, D Davis, CL Abbott, KC Brennan, DC AF Lentine, Krista L. Schnitzler, Mark A. Xiao, Huiling Saab, Georges Salvalaggio, Paolo R. Axelrod, David Davis, Connie L. Abbott, Kevin C. Brennan, Daniel C. TI Racial Variation in Medical Outcomes among Living Kidney Donors SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID STAGE RENAL-DISEASE; UNITED-STATES; HYPERTENSION PREVALENCE; CARDIOVASCULAR-DISEASE; TRANSPLANT RECIPIENTS; MEXICAN-AMERICANS; DIABETES-MELLITUS; DONATION; RATES; AWARENESS AB BACKGROUND Data regarding health outcomes among living kidney donors are lacking, especially among nonwhite persons. METHODS We linked identifiers from the Organ Procurement and Transplantation Network (OPTN) with administrative data of a private U. S. health insurer and performed a retrospective study of 4650 persons who had been living kidney donors from October 1987 through July 2007 and who had post-donation nephrectomy benefits with this insurer at some point from 2000 through 2007. We ascertained post-nephrectomy medical diagnoses and conditions requiring medical treatment from billing claims. Cox regression analyses with left and right censoring to account for observed periods of insurance benefits were used to estimate absolute prevalence and prevalence ratios for diagnoses after nephrectomy. We then compared prevalence patterns with those in the 2005-2006 National Health and Nutrition Examination Survey (NHANES) for the general population. RESULTS Among the donors, 76.3% were white, 13.1% black, 8.2% Hispanic, and 2.4% another race or ethnic group. The median time from donation to the end of insurance benefits was 7.7 years. After kidney donation, black donors, as compared with white donors, had an increased risk of hypertension (adjusted hazard ratio, 1.52; 95% confidence interval [CI], 1.23 to 1.88), diabetes mellitus requiring drug therapy (adjusted hazard ratio, 2.31; 95% CI, 1.33 to 3.98), and chronic kidney disease (adjusted hazard ratio, 2.32; 95% CI, 1.48 to 3.62); findings were similar for Hispanic donors. The absolute prevalence of diabetes among all donors did not exceed that in the general population, but the prevalence of hypertension exceeded NHANES estimates in some subgroups. End-stage renal disease was identified in less than 1% of donors but was more common among black donors than among white donors. CONCLUSIONS As in the general U. S. population, racial disparities in medical conditions occur among living kidney donors. Increased attention to health outcomes among demographically diverse kidney donors is needed. C1 [Lentine, Krista L.] St Louis Univ, Ctr Outcomes Res, Salus Ctr, Sch Med, St Louis, MO 63104 USA. [Lentine, Krista L.] St Louis Univ, Sch Med, Div Nephrol, St Louis, MO 63104 USA. [Saab, Georges; Brennan, Daniel C.] Washington Univ, Div Nephrol, Sch Med, St Louis, MO 63130 USA. [Salvalaggio, Paolo R.; Davis, Connie L.] Univ Washington, Kidney & Pancreas Transplant Program, Seattle, WA 98195 USA. [Axelrod, David] Dartmouth Hitchcock Med Ctr, Dept Surg, Hanover, NH USA. [Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Salus Ctr, Sch Med, 4th Fl,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentinek@slu.edu OI Abbott, Kevin/0000-0003-2111-7112 FU National Institute of Diabetes and Digestive and Kidney Diseases [K08DK073036, P30DK079333] FX Supported in part by grants (K08DK073036 and P30DK079333) from the National Institute of Diabetes and Digestive and Kidney Diseases. NR 39 TC 123 Z9 123 U1 1 U2 4 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD AUG 19 PY 2010 VL 363 IS 8 BP 724 EP 732 DI 10.1056/NEJMoa1000950 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 639TE UT WOS:000280996600006 PM 20818874 ER PT J AU Bergmann-Leitner, ES Mease, RM De La Vega, P Savranskaya, T Polhemus, M Ockenhouse, C Angov, E AF Bergmann-Leitner, Elke S. Mease, Ryan M. De La Vega, Patricia Savranskaya, Tatyana Polhemus, Mark Ockenhouse, Christian Angov, Evelina TI Immunization with Pre-Erythrocytic Antigen CelTOS from Plasmodium falciparum Elicits Cross-Species Protection against Heterologous Challenge with Plasmodium berghei SO PLOS ONE LA English DT Article ID CIRCUMSPOROZOITE PROTEIN; MALARIA INFECTION; GENETIC DIVERSITY; IMMUNE-RESPONSES; VACCINE; SPOROZOITES; EFFICACY; PARASITES; CHILDREN; AFFINITY AB Background: The Plasmodium protein Cell-traversal protein for ookinetes and sporozoites (CelTOS) plays an important role in cell traversal of host cells in both, mosquito and vertebrates, and is required for successful malaria infections. CelTOS is highly conserved among the Plasmodium species, suggesting an important functional role across all species. Therefore, targeting the immune response to this highly conserved protein and thus potentially interfering with its biological function may result in protection against infection even by heterologous species of Plasmodium. Methodology/Principal Findings: To test this hypothesis, we developed a recombinant codon-harmonized P. falciparum CelTOS protein that can be produced to high yields in the E. coli expression system. Inbred Balb/c and outbred CD-1 mice were immunized with various doses of the recombinant protein adjuvanted with Montanide ISA 720 and characterized using in vitro and in vivo analyses. Conclusions/Significance: Immunization with PfCelTOS resulted in potent humoral and cellular immune responses and most importantly induced sterile protection against a heterologous challenge with P. berghei sporozoites in a proportion of both inbred and outbred mice. The biological activity of CelTOS-specific antibodies against the malaria parasite is likely linked to the impairment of sporozoite motility and hepatocyte infectivity. The results underscore the potential of this antigen as a pre-erythrocytic vaccine candidate and demonstrate for the first time a malaria vaccine that is cross-protective between species. C1 [Bergmann-Leitner, Elke S.; Mease, Ryan M.; De La Vega, Patricia; Polhemus, Mark; Ockenhouse, Christian; Angov, Evelina] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Savranskaya, Tatyana] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, US Mil Malaria Vaccine Program, Silver Spring, MD USA. EM Elke.BergmannLeitner@us.army.mil RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 FU United States Agency for International Development [936-3118, GHA-T-00-08-00007-01]; United States Army Medical Research and Material Command FX This work was supported by the United States Agency for International Development under project number 936-3118, award number GHA-T-00-08-00007-01, and by the United States Army Medical Research and Material Command. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 23 TC 40 Z9 41 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 19 PY 2010 VL 5 IS 8 AR e12294 DI 10.1371/journal.pone.0012294 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 640TN UT WOS:000281075500022 PM 20808868 ER PT J AU Derksen, C Toose, P Rees, A Wang, L English, M Walker, A Sturm, M AF Derksen, C. Toose, P. Rees, A. Wang, L. English, M. Walker, A. Sturm, M. TI Development of a tundra-specific snow water equivalent retrieval algorithm for satellite passive microwave data SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE Snow water equivalent; Passive microwave; Tundra; Sub-Arctic ID DEPTH; COVER; ALASKA; USA AB Airborne and satellite brightness temperature (T-B) measurements were combined with intensive field observations of sub-Arctic tundra snow cover to develop the framework for a new tundra-specific passive microwave snow water equivalent (SWE) retrieval algorithm. The dense snowpack and high sub-grid lake fraction across the tundra mean that conventional brightness temperature difference approaches (such as the commonly used 37 GHz-19 GHz) are not appropriate across the sub-Arctic. Airborne radiometer measurements (with footprint dimensions of approximately 70x120 m) acquired across sub-Arctic Canada during three field campaigns during the 2008 winter season were utilized to illustrate a slope reversal in the 37 GHz T-B versus SWE relationship. Scattering by the tundra snowpack drives a negative relationship until a threshold SWE value is reached near 130 mm at which point emission from the snowpack creates a positive but noisier relationship between 37 GHz T-B and SWE. The change from snowpack scattering to emission was also evident in the temporal evolution of 37 GHz T-B observed from satellite measurements. AMSR-E brightness temperatures (2002/03-2006/07) consistently exhibited decreases through the winter before reaching a minimum in February or March, followed by an increase for weeks or months before melt. The cumulative absolute change (Sigma vertical bar Delta 37V vertical bar) in vertically polarized 37 GHz T-B was computed at both monthly and pentad intervals from a January 1 start date and compared to ground measured SWE from intensive and regional snow survey campaigns, and climate station observations. A greater (lower) cumulative change in vertical bar Delta 37V vertical bar was significantly related to greater (lower) ground measured SWE (r(2) = 0.77 with monthly averages: r(2) = 0.67 with pentad averages). Sigma vertical bar Delta 37V vertical bar was only weakly correlated with lake fraction: monthly r(2) values calculated for January through April 2003-2007 were largely less than 0.2. These results indicate that this is a computationally straightforward and viable algorithmic framework for producing tundra-specific SWE datasets from the complete satellite passive microwave record (1979 to present). Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved. C1 [Derksen, C.; Toose, P.; Wang, L.; Walker, A.] Environm Canada, Div Climate Res, Toronto, ON, Canada. [Rees, A.; English, M.] Wilfrid Laurier Univ, Dept Geog & Environm Studies, Waterloo, ON N2L 3C5, Canada. [Sturm, M.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Ft Wainwright, AK USA. RP Derksen, C (reprint author), Environm Canada, Div Climate Res, Toronto, ON, Canada. EM Chris.Derksen@ec.gc.ca FU Government of Canada; National Science Foundation; Cold Regions Research and Engineering Laboratory; Environment Canada; Canadian Foundation for Climate and Atmospheric Science FX Thanks to Ken Asmus, Walter Strapp and Arvids Silis of Environment Canada for support with radiometer measurements and field activities. AMSR-E brightness temperatures were acquired from the National Snow and Ice Data Center, Boulder, Colorado. Field activities during 2008 near Puvirnituq, Daring Lake, and Inuvik were supported by the Government of Canada International Polar Year funding to the 'Variability and Change in the Canadian Cryospere' network project. SnowSTAR 2007 was supported by the National Science Foundation, the Cold Regions Research and Engineering Laboratory, and Environment Canada. Field measurements at Daring Lake prior to 2008 were supported by the Canadian Foundation for Climate and Atmospheric Science. NR 36 TC 42 Z9 46 U1 0 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 EI 1879-0704 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD AUG 16 PY 2010 VL 114 IS 8 BP 1699 EP 1709 DI 10.1016/j.rse.2010.02.019 PG 11 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 612ZD UT WOS:000278943900007 ER PT J AU Ford, WM Rodrigue, JL Rowan, EL Castleberry, SB Schuler, TM AF Ford, W. Mark Rodrigue, Jane L. Rowan, Ella L. Castleberry, Steven B. Schuler, Thomas M. TI Woodland salamander response to two prescribed fires in the central Appalachians SO FOREST ECOLOGY AND MANAGEMENT LA English DT Article DE Central Appalachians; Plethodontidae; Prescribed fire; Woodland salamander ID RED-BACKED SALAMANDERS; TERRESTRIAL SALAMANDERS; PLETHODON-CINEREUS; SOUTHERN APPALACHIANS; HARDWOOD FORESTS; FUEL REDUCTION; UNITED-STATES; SMALL MAMMALS; CANOPY GAPS; AMPHIBIANS AB Using coverboard arrays, we monitored woodland salamanders on the Fernow Experimental Forest in the central Appalachian Mountains, West Virginia, USA prior to and following two prescribed fires in mixed oak (Quercus spp.) forest stands. Treatments were burn plots on upper slopes or lower slopes fenced to prevent white-tailed deer (Odocoileus virginianus) herbivory or control plots that were unfenced and unburned. Most of the 7 species we observed were the mountain dusky salamander (Desmognathus ocropheaus), red-backed salamander (Plethodon cinereus) and slimy salamander (Plethodon glutinosis). Significant population responses were difficult to interpret with numerous treatment and year interactions. Results largely were equivocal. We found no change in woodland salamander assemblage prior to burning or afterwards. There were few differences in adult to juvenile ratios of salamanders among treatments. Still, a priori contrasts of mountain dusky salamanders and red-backed salamander counts corrected for detection probability were greater under coverboards in the 2 years monitored after both prescribed fires had occurred than before burning or in unburned controls. This suggests that these species responded to the reduced leaf litter on the forest floor by utilizing coverboards more. Similarly, the three predominate species of salamanders also were more numerous under coverboards in plots subjected to deer herbivory with less subsequent forest floor vegetation as compared to those burned plots that were fenced. Our observations would suggest that woodland salamanders somewhat are tolerant of two prescribed fires within close temporal proximity. However, because woodland salamanders can be significantly reduced following timber harvest, continued research is needed to fully understand impacts of fire as a pre-harvest management tool in central Appalachian forests. Published by Elsevier B.V. C1 [Ford, W. Mark] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Rodrigue, Jane L.; Schuler, Thomas M.] US Forest Serv, No Res Stn, Parsons, WV 26287 USA. [Rowan, Ella L.] Washington Dept Fish & Wildlife, Spokane Valley, WA 99126 USA. [Castleberry, Steven B.] Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. RP Ford, WM (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM mfordfs@yahoo.com FU West Virginia Division Natural Resource Scientific Collecting Permits; University of Georgia Institutional Animal Care and Use Committee [A2002-10016-0] FX We thank R. Hovatter, P. Myers and R. Rozier for assistance in study installation and J. Stanovick for assistance with statistical design and analysis. Prescribed burning was conducted by personnel from the U.S. Forest Service Northern Research Station and Monongahela National Forest and the West Virginia Division of Forestry. All animals were handled under the auspices of West Virginia Division Natural Resource Scientific Collecting Permits and the University of Georgia Institutional Animal Care and Use Committee (approval number A2002-10016-0). NR 62 TC 10 Z9 10 U1 10 U2 26 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1127 EI 1872-7042 J9 FOREST ECOL MANAG JI For. Ecol. Manage. PD AUG 15 PY 2010 VL 260 IS 6 BP 1003 EP 1009 DI 10.1016/j.foreco.2010.06.022 PG 7 WC Forestry SC Forestry GA 647MY UT WOS:000281623800007 ER PT J AU Nilakantan, G Keefe, M Bogetti, TA Adkinson, R Gillespie, JW AF Nilakantan, Gaurav Keefe, Michael Bogetti, Travis A. Adkinson, Rob Gillespie, John W., Jr. TI On the finite element analysis of woven fabric impact using multiscale modeling techniques SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Fabrics/textiles; Flexible composites; Impact; Finite element; Multiscale modeling ID BALLISTIC IMPACT; ENERGY-ABSORPTION; FRICTION; ARMOR AB Finite element modeling of the impact of flexible woven fabrics using a yarn level architecture allows the capturing of complex projectile-fabric and yarn-yarn level interactions, however it requires very large computational resources. This paper presents a multiscale modeling technique to simulate the impact of flexible woven fabrics. This technique involves modeling the fabric using a yarn level architecture around the impact region and a homogenized or membrane type architecture at far field regions. The level of modeling resolution decreases with distance away from the impact zone. This results in a finite element model with much lower computational requirements. The yarns are modeled using both solid and shell finite elements. Impedances are matched across all interfaces created between the various regions of the model to prevent artificial reflections of the longitudinal strain waves. A systematic approach is presented to determine geometric and material parameters of the homogenized zone. The multiscale model is extensively validated against baseline models. The limitations of using shell elements to model the yarn level architecture underneath the projectile are addressed. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Nilakantan, Gaurav; Keefe, Michael; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Nilakantan, Gaurav; Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Keefe, Michael] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Bogetti, Travis A.; Adkinson, Rob] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM gillespi@udel.edu RI Nilakantan, Gaurav/B-8643-2012 OI Nilakantan, Gaurav/0000-0002-5375-9681 FU US Army Research Laboratory (ARL) at the Aberdeen Proving Grounds, MD, USA FX This research work is financially supported by the US Army Research Laboratory (ARL) at the Aberdeen Proving Grounds, MD, USA through the Composite Materials Research (CMR) program. NR 28 TC 27 Z9 27 U1 0 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD AUG 15 PY 2010 VL 47 IS 17 BP 2300 EP 2315 DI 10.1016/j.ijsolstr.2010.04.029 PG 16 WC Mechanics SC Mechanics GA 620HG UT WOS:000279489100012 ER PT J AU Gao, YH Chen, MK Yang, CE Chang, YC Yao, J Cheng, JP Yin, S Hui, RQ Ruffin, P Brantley, C Edwards, E Luo, C AF Gao, Yaohui Chen, Meng-Ku Yang, Chia En Chang, Yun-Ching Yao, Jim Cheng, Jiping Yin, Stuart Hui, Rongqing Ruffin, Paul Brantley, Christina Edwards, Eugene Luo, Claire TI Detection of concealed and buried chemicals by using multifrequency excitations SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID GAS-PHASE AB In this paper, we present a new type of concealed and buried chemical detection system by stimulating and enhancing spectroscopic signatures with multifrequency excitations, which includes a low frequency gradient dc electric field, a high frequency microwave field, and higher frequency infrared (IR) radiations. Each excitation frequency plays a unique role. The microwave, which can penetrate into the underground and/or pass through the dielectric covers with low attenuation, could effectively transform its energy into the concealed and buried chemicals and increases its evaporation rate from the sample source. Subsequently, a gradient dc electric field, generated by a Van De Graaff generator, not only serves as a vapor accelerator for efficiently expediting the transportation process of the vapor release from the concealed and buried chemicals but also acts as a vapor concentrator for increasing the chemical concentrations in the detection area, which enables the trace level chemical detection. Finally, the stimulated and enhanced vapors on the surface are detected by the IR spectroscopic fingerprints. Our theoretical and experimental results demonstrate that more than sixfold increase in detection signal can be achieved by using this proposed technology. The proposed technology can also be used for standoff detection of concealed and buried chemicals by adding the remote IR and/or thermal spectroscopic and imaging detection systems. (C) 2010 American Institute of Physics. [doi:10.1063/1.3474651] C1 [Gao, Yaohui; Chen, Meng-Ku; Yang, Chia En; Chang, Yun-Ching; Yao, Jim; Cheng, Jiping; Yin, Stuart] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Hui, Rongqing] Univ Kansas, Dept Elect Engn & Comp Sci, Lawrence, KS 66045 USA. [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. [Luo, Claire] Gen Opto Solut LLC, State Coll, PA 16803 USA. RP Gao, YH (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu FU ONR FX Authors greatly acknowledge the partial financial support of this work by an ONR basic research program. NR 10 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 15 PY 2010 VL 108 IS 4 AR 043106 DI 10.1063/1.3474651 PG 6 WC Physics, Applied SC Physics GA 650NV UT WOS:000281857100019 ER PT J AU Kamerath, J Morgan, WE AF Kamerath, Joseph Morgan, William E. TI Absent Inferior Vena Cava Resulting in Exercise-Induced Epidural Venous Plexus Congestion and Lower Extremity Numbness A Case Report and Review of the Literature SO SPINE LA English DT Review DE absent inferior vena cava; epidural venous plexus; cauda equina syndrome; nerve root compression syndrome ID DEEP-VEIN THROMBOSIS; BACK-PAIN; CONGENITAL ABSENCE; RADICULOPATHY; ENGORGEMENT; VENOGRAPHY; SCIATICA; RISK; CT AB Study Design. Case report and clinical discussion. Objective. To describe a unique etiology for a patient presenting with exercise-induced lower extremity numbness found to have agenesis of the infrarenal inferior vena cava (IVC) and a large vein draining the confluence of the iliac veins through the L4 foramen into the epidural plexus. Summary of Background Data. Epidural venous abnormalities are infrequently determined to be the etiology of nerve root compression syndromes. Such cases have been described in patients with absent IVC with thrombosis. We are unaware of any previously described cases of absent IVC with a primary route of venous return through the epidural venous plexus, resulting in symptoms in the absence of thrombosis. Methods. We describe a case of a 34-year-old man who presented complaining of numbness of legs as well as cauda equina symptoms occurring during exercise. He was found to have infrarenal absence of the IVC with the confluence of the iliac veins forming a large draining vein which entered the L4 foramen into the epidural venous plexus. Pre- and postexercise magnetic resonance imaging scans were performed to compare change in the size of the plexus. Results. Postexercise magnetic resonance imaging showed notable increase in the volume of the epidural venous plexus of the lower lumbar spine. The patient was referred to neurosurgery and vascular surgery, which did not intervene. On follow-up 2 years later, the patient developed significant right deep venous thrombosis and was found to be heterozygous for factor V Leiden mutation. Conclusion. This case demonstrates the breadth of anatomic and physiologic understanding a clinician must draw on when approaching patients with nerve root compression symptoms. It is also pertinent to consider performing a hypercoagulable work-up in patients with vascular deformations, as this may prevent future thrombosis. C1 [Kamerath, Joseph] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Morgan, William E.] Natl Naval Med Ctr, Chiropract Dept, Bethesda, MD USA. RP Kamerath, J (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM joseph.kamerath@us.army.mil NR 23 TC 0 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD AUG 15 PY 2010 VL 35 IS 18 BP E921 EP E924 DI 10.1097/BRS.0b013e3181e83d6e PG 4 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 643EF UT WOS:000281277700023 PM 21381233 ER PT J AU Lewis, RJ Poli, M AF Lewis, Richard J. Poli, Mark TI Toxins in Seafood SO TOXICON LA English DT Editorial Material C1 [Lewis, Richard J.] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia. [Poli, Mark] US Army, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21701 USA. RP Lewis, RJ (reprint author), Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia. EM r.lewis@imb.uq.edu.au; mark.poli@us.army.mil RI Lewis, Richard/E-8674-2013 OI Lewis, Richard/0000-0003-3470-923X NR 0 TC 3 Z9 4 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD AUG 15 PY 2010 VL 56 IS 2 SI SI BP 107 EP 107 DI 10.1016/j.toxicon.2010.05.002 PG 1 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 614NC UT WOS:000279065100001 PM 20510727 ER PT J AU Izvekov, S Chung, PW Rice, BM AF Izvekov, Sergei Chung, Peter W. Rice, Betsy M. TI The multiscale coarse-graining method: Assessing its accuracy and introducing density dependent coarse-grain potentials SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article DE compressibility; crystal structure; free energy; liquid structure; liquid theory; organic compounds ID MOLECULAR-DYNAMICS SIMULATIONS; RADIAL-DISTRIBUTION FUNCTIONS; SHOCKED LIQUID NITROMETHANE; EQUATION-OF-STATE; SOLID NITROMETHANE; FORCE-FIELD; ATOMISTIC SIMULATIONS; BIOMOLECULAR SYSTEMS; MEMBRANE-PROTEINS; FREE-ENERGY AB The ability of particle-based coarse-grain potentials, derived using the recently proposed multiscale coarse-graining (MS-CG) methodology [S. Izvekov and G. A. Voth, J. Phys. Chem. B 109, 2469 (2005); J. Chem. Phys. 123, 134105 (2005)] to reconstruct atomistic free-energy surfaces in coarse-grain coordinates is discussed. The MS-CG method is based on force-matching generalized forces associated with the coarse-grain coordinates. In this work, we show that the MS-CG method recovers only part of the atomistic free-energy landscape in the coarse-grain coordinates (termed the potential of mean force contribution). The portion of the atomistic free-energy landscape that is left out in the MS-CG procedure contributes to a pressure difference between atomistic and coarse-grain ensembles. Employing one- and two-site coarse-graining of nitromethane as worked examples, we discuss the virial and compressibility constraints to incorporate a pressure correction interaction into the MS-CG potentials and improve performance at different densities. The nature of the pressure correction interaction is elucidated and compared with those used in structure-based coarse-graining. As pairwise approximations to the atomistic free-energy, the MS-CG potentials naturally depend on the variables describing a thermodynamic state, such as temperature and density. Such dependencies limit state-point transferability. For nitromethane, the one- and two-site MS-CG potentials appear to be transferable across a broad range of temperatures. In particular, the two-site models, which are matched to low and ambient temperature liquid states, perform well in simulations of the ambient crystal structure. In contrast, the transferability of the MS-CG models of nitromethane across different densities is found to be problematic. To achieve better state-point transferability, density dependent MS-CG potentials are introduced and their performance is examined in simulations of nitromethane under various thermodynamic conditions, including shocked states. (C) 2010 American Institute of Physics. [doi:10.1063/1.3464776] C1 [Izvekov, Sergei; Chung, Peter W.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM sergiy.izvyekov@us.army.mil FU DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions; U.S. Army Research Laboratory FX This research was supported by the DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. This project was supported in part by an appointment to the Internship/Research Participation Program for the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education. NR 85 TC 45 Z9 45 U1 3 U2 39 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD AUG 14 PY 2010 VL 133 IS 6 AR 064109 DI 10.1063/1.3464776 PG 16 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 638ZY UT WOS:000280941800012 PM 20707563 ER PT J AU Dalyander, PS Cerco, CF AF Dalyander, P. Soupy Cerco, Carl F. TI Integration of a fish bioenergetics model into a spatially explicit water quality model: Application to menhaden in Chesapeake Bay SO ECOLOGICAL MODELLING LA English DT Article DE Fish bioenergetics; Eutrophication modeling; Water quality modeling; Chesapeake Bay; Atlantic menhaden ID BREVOORTIA-TYRANNUS PISCES; ATLANTIC MENHADEN; NARRAGANSETT BAY; GULF MENHADEN; RHODE-ISLAND; EUTROPHICATION; NUTRIENT; NITROGEN; DYNAMICS; PHYTOPLANKTON AB Although fish are usually thought of as victims of water quality degradation, it has been proposed that some planktivorous species may improve water quality through consumption of algae and sequestering of nutrients via growth. Within most numerical water quality models, the highest trophic level modeled explicitly is zooplankton, prohibiting an investigation of the effect a fish species may be having on its environment. Conversely, numerical models of fish consumption do not typically include feedback mechanisms to capture the effects of fish on primary production and nutrient recycling. In the present study, a fish bioenergetics model is incorporated into CE-QUAL-ICM, a spatially explicit eutrophication model. In addition to fish consumption of algae, zooplankton, and detritus, fish biomass accumulation and nutrient recycling to the water column are explicitly accounted for. These developments advance prior modeling efforts of the impact of fish on water quality, many of which are based on integrated estimates over an entire system and which omit the feedback the fish have through nutrient recycling and excretion. To validate the developments, a pilot application was undertaken for Atlantic menhaden (Brevoortia tyrannus) in Chesapeake Bay. The model indicates menhaden may reduce the algal biomass while simultaneously increasing primary productivity. Published by Elsevier B.V. C1 [Dalyander, P. Soupy; Cerco, Carl F.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Dalyander, PS (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Mail Stop EP-W,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Patricia.A.Dalyander@usace.army.mil RI Dalyander, Soupy/E-9830-2013 FU U.S. Army Corps of Engineers; Environmental Protection Agency (EPA) FX Dave Smith obtained menhaden population data and compiled estimates of school size and age structure. Terry Gerald devised the initial school bookkeeping algorithms in Fortran. Mark Noel provided assistance on the operation of CE-QUAL-ICM. This work was funded by the U.S. Army Corps of Engineers System-Wide Water Resources Program (SWWRP) and the Environmental Protection Agency (EPA) Chesapeake Bay Program Office. NR 57 TC 8 Z9 8 U1 1 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD AUG 10 PY 2010 VL 221 IS 16 BP 1922 EP 1933 DI 10.1016/j.ecolmodel.2010.05.002 PG 12 WC Ecology SC Environmental Sciences & Ecology GA 625IW UT WOS:000279889700009 ER PT J AU Howes, NC FitzGerald, DM Hughes, ZJ Georgiou, IY Kulp, MA Miner, MD Smith, JM Barras, JA AF Howes, Nick C. FitzGerald, Duncan M. Hughes, Zoe J. Georgiou, Ioannis Y. Kulp, Mark A. Miner, Michael D. Smith, Jane M. Barras, John A. TI Hurricane-induced failure of low salinity wetlands SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE wetland loss; Mississippi Delta; shear stress; soil shear strength; vegetation roughness ID MISSISSIPPI RIVER DELTA; MARSH VEGETATION TYPES; SALT-MARSH; SPARTINA-ALTERNIFLORA; NEW-ENGLAND; LOUISIANA; EROSION; PLAIN; TURBULENCE; USA AB During the 2005 hurricane season, the storm surge and wave field associated with Hurricanes Katrina and Rita eroded 527 km(2) of wetlands within the Louisiana coastal plain. Low salinity wetlands were preferentially eroded, while higher salinity wetlands remained robust and largely unchanged. Here we highlight geotechnical differences between the soil profiles of high and low salinity regimes, which are controlled by vegetation and result in differential erosion. In low salinity wetlands, a weak zone (shear strength 500-1450 Pa) was observed similar to 30 cm below the marsh surface, coinciding with the base of rooting. High salinity wetlands had no such zone (shear strengths > 4500 Pa) and contained deeper rooting. Storm waves during Hurricane Katrina produced shear stresses between 425-3600 Pa, sufficient to cause widespread erosion of the low salinity wetlands. Vegetation in low salinity marshes is subject to shallower rooting and is susceptible to erosion during large magnitude storms; these conditions may be exacerbated by low inorganic sediment content and high nutrient inputs. The dramatic difference in resiliency of fresh versus more saline marshes suggests that the introduction of freshwater to marshes as part of restoration efforts may therefore weaken existing wetlands rendering them vulnerable to hurricanes. C1 [Howes, Nick C.; FitzGerald, Duncan M.; Hughes, Zoe J.] Boston Univ, Dept Earth Sci, Boston, MA 02215 USA. [Georgiou, Ioannis Y.; Kulp, Mark A.; Miner, Michael D.] Univ New Orleans, Pontchartrain Inst Environm Sci, New Orleans, LA 70148 USA. [Smith, Jane M.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Barras, John A.] USA, Engineer Res & Dev Ctr, Environm Lab, Wetlands Environm Technol Res Facil, Baton Rouge, LA 70803 USA. RP Howes, NC (reprint author), Boston Univ, Dept Earth Sci, 675 Commonwealth Ave, Boston, MA 02215 USA. EM nchowes@gmail.com FU National Oceanic and Atmospheric Administration Pontchartrain Restoration [NA06 NOS4630026]; U.S. Geological Survey Northern Gulf of Mexico (NGOM) FX We gratefully acknowledge field assistance received from M. Brown, P. McCarty, and J. Motti. This work was primarily funded by National Oceanic and Atmospheric Administration Pontchartrain Restoration Program Grant NA06 NOS4630026 awarded to the University of New Orleans and Boston University. U.S. Geological Survey Northern Gulf of Mexico (NGOM) Ecosystem Change and Hazard Susceptibility Project provided funding for the land loss mapping. NR 41 TC 73 Z9 74 U1 10 U2 57 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 10 PY 2010 VL 107 IS 32 BP 14014 EP 14019 DI 10.1073/pnas.0914582107 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 636UD UT WOS:000280767700010 PM 20660777 ER PT J AU Michelow, IC Dong, MD Mungall, BA Yantosca, LM Lear, C Ji, X Karpel, M Rootes, CL Brudner, M Houen, G Eisen, DP Kinane, TB Takahashi, K Stahl, GL Olinger, GG Spear, GT Ezekowitz, RAB Schmidt, EV AF Michelow, Ian C. Dong, Mingdong Mungall, Bruce A. Yantosca, L. Michael Lear, Calli Ji, Xin Karpel, Marshall Rootes, Christina L. Brudner, Matthew Houen, Gunnar Eisen, Damon P. Kinane, T. Bernard Takahashi, Kazue Stahl, Gregory L. Olinger, Gene G. Spear, Gregory T. Ezekowitz, R. Alan B. Schmidt, Emmett V. TI A Novel L-ficolin/Mannose-binding Lectin Chimeric Molecule with Enhanced Activity against Ebola Virus SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID PATTERN-RECOGNITION MOLECULE; CELL-SURFACE CALRETICULIN; SERINE PROTEASES; OPSONIC ACTIVITY; DEFICIENT MICE; HUMAN PLASMA; L-FICOLIN; PROTEIN; COMPLEMENT; SITE AB Ebola viruses constitute a newly emerging public threat because they cause rapidly fatal hemorrhagic fevers for which no treatment exists, and they can be manipulated as bioweapons. We targeted conserved N-glycosylated carbohydrate ligands on viral envelope surfaces using novel immune therapies. Mannose-binding lectin (MBL) and L-ficolin (L-FCN) were selected because they function as opsonins and activate complement. Given that MBL has a complex quaternary structure unsuitable for large scale cost-effective production, we sought to develop a less complex chimeric fusion protein with similar ligand recognition and enhanced effector functions. We tested recombinant human MBL and three L-FCN/MBL variants that contained the MBL carbohydrate recognition domain and varying lengths of the L-FCN collagenous domain. Non-reduced chimeric proteins formed predominantly nona-and dodecameric oligomers, whereas recombinant human MBL formed octadecameric and larger oligomers. Surface plasmon resonance revealed that L-FCN/MBL76 had the highest binding affinities for N-acetylglucosamine-bovine serum albumin and mannan. The same chimeric protein displayed superior complement C4 cleavage and binding to calreticulin (cC1qR), a putative receptor for MBL. L-FCN/MBL76 reduced infection by wild type Ebola virus Zaire significantly greater than the other molecules. Tapping mode atomic force microscopy revealed that L-FCN/MBL76 was significantly less tall than the other molecules despite similar polypeptide lengths. We propose that alterations in the quaternary structure of L-FCN/MBL76 resulted in greater flexibility in the collagenous or neck region. Similarly, a more pliable molecule might enhance cooperativity between the carbohydrate recognition domains and their cognate ligands, complement activation, and calreticulin binding dynamics. L-FCN/MBL chimeric proteins should be considered as potential novel therapeutics. C1 [Michelow, Ian C.; Brudner, Matthew; Kinane, T. Bernard; Takahashi, Kazue] Harvard Univ, Sch Med, Dept Pediat, Massachusetts Gen Hosp,Program Dev Immunol, Boston, MA 02114 USA. [Dong, Mingdong] Univ Aarhus, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus, Denmark. [Mungall, Bruce A.; Rootes, Christina L.] Commonwealth Sci & Ind Res Org Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia. [Lear, Calli; Olinger, Gene G.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Ji, Xin; Spear, Gregory T.] Rush Univ, Med Ctr, Dept Immunol Microbiol, Chicago, IL 60612 USA. [Houen, Gunnar] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark. [Eisen, Damon P.] Royal Melbourne Hosp, Victorian Infect Dis Serv, Parkville, Vic 3050, Australia. [Stahl, Gregory L.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. RP Michelow, IC (reprint author), Harvard Univ, Sch Med, Dept Pediat, Massachusetts Gen Hosp,Program Dev Immunol, 55 Fruit St,GRJ 1402, Boston, MA 02114 USA. EM imichelow@partners.org RI Dong, Mingdong/B-3341-2010; OI Dong, Mingdong/0000-0002-2025-2171; Olinger, Gene/0000-0001-7338-0292; Houen, Gunnar/0000-0002-5948-4156 FU National Institutes of Health [U01 AI070330, R01 HL52886, R01 HL56086, R21 HL092469, P50 DE016191]; United States Department of Defense, Defense Threat Reduction Agency [4.10006, 4.10007] FX This work was supported, in whole or in part, by National Institutes of Health Grants U01 AI070330 (to E. V. S.) and R01 HL52886, R01 HL56086, R21 HL092469, and P50 DE016191 (to G. L. S.). This work was also supported by United States Department of Defense, Defense Threat Reduction Agency Biological Therapeutics Program Grants 4.10006 and 4.10007 (to G. G. O.). NR 47 TC 31 Z9 33 U1 0 U2 9 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD AUG 6 PY 2010 VL 285 IS 32 BP 24729 EP 24739 DI 10.1074/jbc.M110.106260 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 633YB UT WOS:000280542100045 PM 20516066 ER PT J AU Li, B Brown, KV Wenke, JC Guelcher, SA AF Li, Bing Brown, Kate V. Wenke, Joseph C. Guelcher, Scott A. TI Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model SO JOURNAL OF CONTROLLED RELEASE LA English DT Article DE Polyurethane; Vancomycin; Sustained release; Infection control; Rat femoral segmental defect; Bone tissue engineering ID RESISTANT STAPHYLOCOCCUS-AUREUS; IN-VITRO; ANTIBIOTIC BEADS; GROWTH-FACTOR; TOTAL HIP; POLYMETHYLMETHACRYLATE BEADS; KNEE ARTHROPLASTY; DELIVERY SYSTEMS; 2-STAGE REVISION; CEMENT SPACERS AB Infection is a common complication in open fractures that compromises the healing of bone and can result in loss of limb or life. Currently, the clinical standard of care for treating contaminated open fractures comprises a staged approach, wherein the wound is first treated with non-biodegradable antibiotic-laden poly(methyl methacrylate) (PMMA) beads to control the infection followed by bone grafting. Considering that tissue regeneration is associated with new blood vessel formation, which takes up to 6 weeks in segmental defects, a biodegradable bone graft with sustained release of an antibiotic is desired to prevent the implant from becoming infected, thus allowing the processes of both vascularization and new bone formation to occur unimpeded. In the present study, we utilized biodegradable porous polyurethane (PUR) scaffolds as the delivery vehicle for vancomycin. Hydrophobic vancomycin free base (V-FB) was obtained by precipitating the hydrophilic vancomycin hydrochloride (V-HCl) at pH 8. The decreased solubility of V-FB resulted in an extended vancomycin release profile in vitro, as evidenced by the fact that active vancomycin was released for up to 8 weeks at concentrations well above both the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). Using PUR prepared from lysine triisocyanate (LTI) (PUR(LTI)), the extended in vitro release profile observed for V-FB translated to improved infection control in vivo compared to V-HCl in a contaminated critical-sized fat femoral segmental defect. The performance of PUR (LTI)/V-FB was comparable to PMMA/V-HCl beads in vivo. However, compared with PMMA, PUR is a biodegradable system which does not require the extra surgical removal step in clinical use. These results suggest that PUR scaffolds incorporating V-FB could be a potential clinical therapy for treatment of infected bone defects. (c) 2010 Elsevier B.V. All rights reserved. C1 [Li, Bing; Guelcher, Scott A.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Li, Bing; Guelcher, Scott A.] Vanderbilt Univ, Ctr Bone Biol, Nashville, TN 37235 USA. [Brown, Kate V.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Guelcher, SA (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, 2301 Vanderbilt Pl,VU Stn B 351604, Nashville, TN 37235 USA. EM scott.guelcher@vanderbilt.edu FU Orthopaedic Extremity Trauma Research Program [DOD-W81XWH-07-1-0211]; US Army Institute of Surgical Research FX This work was funded by the Orthopaedic Extremity Trauma Research Program (DOD-W81XWH-07-1-0211) and the US Army Institute of Surgical Research. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. No benefits in any form have been received from a commercial party related directly or indirectly to the subject of this article. NR 68 TC 82 Z9 84 U1 4 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-3659 J9 J CONTROL RELEASE JI J. Control. Release PD AUG 3 PY 2010 VL 145 IS 3 BP 221 EP 230 DI 10.1016/j.jconrel.2010.04.002 PG 10 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA 631UO UT WOS:000280375600008 PM 20382191 ER PT J AU Donetsky, D Belenky, G Svensson, S Suchalkin, S AF Donetsky, Dmitry Belenky, Gregory Svensson, Stefan Suchalkin, Sergei TI Minority carrier lifetime in type-2 InAs-GaSb strained-layer superlattices and bulk HgCdTe materials SO APPLIED PHYSICS LETTERS LA English DT Article ID RECOMBINATION RATES; PHOTODETECTORS; GAP AB Minority carrier lifetime, tau, in type-2 strained-layer superlattices (SLSs) and in long-wave Hg(0.78)Cd(0.22)Te (MCT) was measured by optical modulation response technique. It was shown that at 77 K radiative recombination can contribute to the measured tau values. The Shockley-Read-Hall (SRH) lifetimes were attained as 100 ns, 31 ns, and more than 1 mu s for midwave infrared superlattices, long-wave infrared (LWIR) superlattices, and MCT correspondingly. The nature of the difference between the SRH lifetimes in LWIR superlattice and MCT is discussed. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3476352] C1 [Donetsky, Dmitry; Belenky, Gregory; Suchalkin, Sergei] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. [Svensson, Stefan] USA, Res Lab, Adelphi, MD 20783 USA. [Belenky, Gregory; Suchalkin, Sergei] Power Photon Corp, Stony Brook, NY 11790 USA. RP Donetsky, D (reprint author), SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. EM garik@ece.sunysb.edu FU NVESD; NSF [DMR071054] FX LWIR SLS and MCT structures used for measurements were provided by NVESD. The authors are grateful to J. Pellegrino, M. Tidrow, and S. Bandara for helpful discussions and encouragement. This work was supported by NVESD and NSF Award No. DMR071054. NR 22 TC 66 Z9 66 U1 2 U2 23 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 2 PY 2010 VL 97 IS 5 AR 052108 DI 10.1063/1.3476352 PG 3 WC Physics, Applied SC Physics GA 640NY UT WOS:000281059500031 ER PT J AU Newburgh, GA Michael, A Dubinskii, M AF Newburgh, G. A. Michael, A. Dubinskii, M. TI Composite Yb:YAG/SiC-prism thin disk laser SO OPTICS EXPRESS LA English DT Article ID SOLID-STATE LASERS; ND-YAG; SLAB LASERS; YB-YAG; POWER; DIAMOND; GROWTH AB We report the first demonstration of a Yb:YAG thin disk laser wherein the gain medium is intracavity face-cooled through bonding to an optical quality SiC prism. Due to the particular design of the composite bonded Yb:YAG/SiC-prism gain element, the laser beam impinges on all refractive index interfaces inside the laser cavity at Brewster's angles. The laser beam undergoes total internal reflection (TIR) at the bottom of the Yb(10%):YAG thin disk layer in a V-bounce cavity configuration. Through the use of TIR and Brewster's angles, no optical coatings, either antireflective (AR) or highly reflective (HR), are required inside the laser cavity. In this first demonstration, the 936.5-nm diode pumped laser performed with similar to 38% slope efficiency at 12 W of quasi-CW (Q-CW) output power at 1030 nm with a beam quality measured at M-2 = 1.5. This demonstration opens up a viable path toward novel thin disk laser designs with efficient double-sided room-temperature heatsinking via materials with the thermal conductivity of copper on both sides of the disk. (C) 2010 Optical Society of America C1 [Newburgh, G. A.; Michael, A.; Dubinskii, M.] US Army, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. RP Newburgh, GA (reprint author), US Army, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gnewburgh@arl.army.mil NR 25 TC 9 Z9 9 U1 0 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD AUG 2 PY 2010 VL 18 IS 16 BP 17066 EP 17074 DI 10.1364/OE.18.017066 PG 9 WC Optics SC Optics GA 640IB UT WOS:000281042400081 PM 20721095 ER PT J AU Summers, RM Liu, JM Rehani, B Stafford, P Brown, L Louie, A Barlow, DS Jensen, DW Cash, B Choi, JR Pickhardt, PJ Petrick, N AF Summers, Ronald M. Liu, Jiamin Rehani, Bhavya Stafford, Phillip Brown, Linda Louie, Adeline Barlow, Duncan S. Jensen, Donald W. Cash, Brooks Choi, J. Richard Pickhardt, Perry J. Petrick, Nicholas TI CT Colonography Computer-Aided Polyp Detection: Effect on Radiologist Observers of Polyp Identification by CAD on Both the Supine and Prone Scans SO ACADEMIC RADIOLOGY LA English DT Article DE CT; colon; CT; virtual imaging; colon cancer; image processing; automated detection; observer performance ID TOMOGRAPHIC VIRTUAL COLONOSCOPY; MAMMOGRAPHIC VIEWS; READER PARADIGM; 2ND READER; PERFORMANCE; SENSITIVITY; SCHEME AB Rationale and Objectives: To determine whether the display of computer-aided detection (CAD) marks on individual polyps on both the supine and prone scans leads to improved polyp detection by radiologists compared to the display of CAD marks on individual polyps on either the supine or the prone scan, but not both. Materials and Methods: The acquisition of patient data for this study was approved by the Institutional Review Board and was Health Insurance Portability and Accountability Act-compliant. Subsequently, the use of the data was declared exempt from further institutional review board review. Four radiologists interpreted 33 computed tomography colonography cases, 21 of which had one adenoma 6-9 mm in size, with the assistance of a CAD system in the first reader mode (ie, the radiologists reviewed only the CAD marks). The radiologists were shown each case twice, with different sets of CAD marks for each of the two readings. In one reading, a true-positive CAD mark for the same polyp was displayed on both the supine and prone scans (a double-mark reading). In the other reading, a true-positive CAD mark was displayed either on the supine or prone scan, but not both (a single-mark reading). True-positive marks were randomized between readings and there was at least a 1-month delay between readings to minimize recall bias. Sensitivity and specificity were determined and receiver operating characteristic (ROC) and multiple-reader multiple-case analyses were performed. Results: The average per polyp sensitivities were 60% (38%-81%) versus 71% (52%-91%) (P = .03) for single-mark and double-mark readings, respectively. The areas (95% confidence intervals) under the ROC curves were 0.76 (0.62-0.88) and 0.79 (0.58-0.96), respectively (P = NS). Specificities were similar for the single-mark compared with the double-mark readings. Conclusion: The display of CAD marks on a polyp on both the supine and prone scans led to more frequent detection of polyps by radiologists without adversely affecting specificity for detecting 6-9 mm adenomas. C1 [Summers, Ronald M.; Liu, Jiamin; Rehani, Bhavya; Stafford, Phillip; Brown, Linda; Louie, Adeline] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bethesda, MD 20892 USA. [Barlow, Duncan S.; Jensen, Donald W.; Cash, Brooks] Natl Naval Med Ctr, Colon Hlth Initiat, Bethesda, MD USA. [Choi, J. Richard] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Pickhardt, Perry J.] Univ Wisconsin, Sch Med, Dept Radiol, Madison, WI USA. [Petrick, Nicholas] US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD USA. RP Summers, RM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Ctr Clin, Bldg 10,Room 1C368X MSC 1182, Bethesda, MD 20892 USA. EM rms@nih.gov FU National Institutes of Health (NIH); National Institute of Biomedical Imaging and Bioengineering FX From the Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bldg. 10, Room 1C368X MSC 1182, Bethesda, MD 20892-1182 (R.M.S., J.L., B.R., P.S., LB., A.L.); Colon Health Initiative, National Naval Medical Center, Bethesda, MD (D.S.B., D.W.J., B.C.); Walter Reed Army Medical Center, Washington, DC (J.R.C.); Department of Radiology, University of Wisconsin Medical School, Madison, WI (P.J.P); Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD (NP.) Received February 15, 2010; accepted March 26, 2010. Presented in part at the 2008 meeting of CARS, Barcelona, Spain. Supported in part by the Intramural Research Program of the National Institutes of Health (NIH) Clinical Center and the National Institute of Biomedical Imaging and Bioengineering (NP.). R.M.S. has pending and/or awarded patents for the subject matter described in the manuscript and receives royalty income for a patent license from iCAD. His lab is supported in part by a Cooperative Research and Development Agreement with iCAD. Viatronix supplied the V3D Colon software to NIH free of charge. P.J.P. is on the medical advisory boards of Viatronix, Inc, and Medicsight, Inc, a consultant to Covidien and co-founder of VirtuoCTC. J.R.C. is on the medical advisory boards of Viatronix, Inc, and QI and has received research support from E-Z-EM. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government and no official endorsement of any equipment or product of any company mentioned in the publication should be inferred. Address correspondence to: R.M.S. e-mail: rms@nih.gov NR 31 TC 9 Z9 9 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1076-6332 EI 1878-4046 J9 ACAD RADIOL JI Acad. Radiol. PD AUG PY 2010 VL 17 IS 8 BP 948 EP 959 DI 10.1016/j.acra.2010.03.024 PG 12 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 627IO UT WOS:000280032900002 PM 20542452 ER PT J AU Singer, DE Bautista, CT O'Connell, RJ Sanders-Buell, E Agan, BK Kijak, GH Hakre, S Sanchez, JL Sateren, WB McCutchan, FE Michael, NL Scott, PT AF Singer, Darrell E. Bautista, Christian T. O'Connell, Robert J. Sanders-Buell, Eric Agan, Brian K. Kijak, Gustavo H. Hakre, Shilpa Sanchez, Jose L. Sateren, Warren B. McCutchan, Francine E. Michael, Nelson L. Scott, Paul T. TI HIV Infection Among US Army and Air Force Military Personnel: Sociodemographic and Genotyping Analysis SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; NON-B SUBTYPES; UNITED-STATES; GENETIC SUBTYPES; DRUG-RESISTANCE; DIVERSITY; SEROCONVERSION; PREVALENCE; SURVEILLANCE; TRENDS AB Since 1985, the U. S. Department of Defense has periodically screened all military personnel for HIV allowing for the monitoring of the infection in this dynamic cohort population. A nested case-control study was performed to study sociodemographics, overseas assignment, and molecular analysis of HIV. Cases were newly identified HIV infections among U. S. Army and Air Force military personnel from 2000 to 2004. Controls were frequency matched to cases by gender and date of case first positive HIV screening test. Genotyping analysis was performed using high-throughput screening assays and partial genome sequencing. HIV was significantly associated with black race [odds ratio (OR) = 6.65], single marital status (OR = 4.45), and age (OR per year = 1.07). Ninety-seven percent were subtype B and 3% were non-B subtypes (A3, CRF01_AE, A/C recombinant, G, CRF02_AG). Among cases, overseas assignment in the period at risk prior to their first HIV-positive test was associated with non-B HIV subtype infection (OR = 8.44). Black and single military personnel remain disproportionately affected by HIV infection. Most non-B HIV subtypes were associated with overseas assignment. Given the increased frequency and length of assignments, and the expanding HIV genetic diversity observed in this population, there is a need for active HIV genotyping surveillance and a need to reinforce primary HIV prevention efforts. C1 [Scott, Paul T.] Walter Reed Army Inst Res, Div Retrovirol, Dept Epidemiol & Threat Assessment, Rockville, MD 20850 USA. [Bautista, Christian T.; Sanders-Buell, Eric; Kijak, Gustavo H.; Hakre, Shilpa] Henry Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Rockville, MD USA. [Singer, Darrell E.] Dept Def HIV Program Nigeria, Abuja, Nigeria. [O'Connell, Robert J.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Sanchez, Jose L.] Armed Forces Hlth Surveillance Ctr, Dept Def Global Emerging Surveillance & Response, Silver Spring, MD USA. [McCutchan, Francine E.] Bill & Melinda Gates Fdn, Seattle, WA USA. RP Scott, PT (reprint author), Walter Reed Army Inst Res, Div Retrovirol, Dept Epidemiol & Threat Assessment, Rockville, MD 20850 USA. EM pscott@hivresearch.org RI Bautista, Christian/B-2812-2011; OI Agan, Brian/0000-0002-5114-1669 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W8IXWH-07-2-0067]; U.S. Department of Defense (DOD) [W8IXWH-07-2-0067] FX We thank the Armed Forces Health Surveillance Center for providing data and specimens for analysis and Sebastian-Santiago B. for technical assistance. This research study (WRAIR #1169/RV161) was approved and reviewed by the Walter Reed Army Institute of Research, Rockville, Maryland. This work was supported by a cooperative agreement (W8IXWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The views expressed are those of the authors and should not be of the U.S. Army or DOD. NR 38 TC 10 Z9 10 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 2010 VL 26 IS 8 BP 889 EP 894 DI 10.1089/aid.2009.0289 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 637YK UT WOS:000280854400008 PM 20673143 ER PT J AU Pamuk, ON Lapchak, PH Rani, P Pine, P Lucca, JJD Tsokos, GC AF Pamuk, Omer Nuri Lapchak, Peter H. Rani, Poonam Pine, Polly Lucca, Jurandir J. Dalle Tsokos, George C. TI Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY LA English DT Article DE Syk; Syk inhibition; R788 ID COMPLEMENT-MEDIATED PHAGOCYTOSIS; MESENTERIC ISCHEMIA/REPERFUSION; SYK KINASE; INJURY; EXPRESSION; CELLS; NEUTROPHILS; AUTOIMMUNE; ANTIBODY; DISEASES AB Pamuk ON, Lapchak PH, Rani P, Pine P, Dalle Lucca JJ, Tsokos GC. Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol 299: G391-G399, 2010. First published June 3, 2010; doi: 10.1152/ajpgi.00198.2010.-Reperfusion injury to tissue following an ischemic event occurs as a consequence of an acute inflammatory response that can cause significant morbidity and mortality. Components of both the innate (complement, immunoglobulin, monocytes, and neutrophils) and adaptive (B and T lymphocytes) immune systems have been demonstrated to mediate tissue injury. Spleen tyrosine kinase (Syk) is responsible for membrane-mediated signaling in various cell types including B lymphocytes, macrophages, and T cells. We investigated the ability of a small drug Syk inhibitor, R788, to protect mice against mesenteric ischemia-reperfusion (I/R)-induced local (intestine) and remote lung injury. Mice were fed with chow containing a Syk inhibitor for 6 days before the performance of intestinal I/R, which resulted in silencing of the expression of the active phosphorylated Syk. Syk inhibition significantly suppressed both local and remote lung injury. The beneficial effect was associated with reduced IgM and complement 3 deposition in the tissues and significant reduction of polymorphonuclear cell infiltration. Our data place Syk upstream of events leading to the binding of natural antibodies to the ischemia-conditioned tissues and urge the consideration of the use of Syk inhibitors in the prevention or improvement of tissue injury of organs exposed to ischemia or hypoperfusion. C1 [Tsokos, George C.] Harvard Univ, Sch Med, Dept Med, Div Rheumatol,Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA. [Pamuk, Omer Nuri] Trakya Univ, Sch Med, Div Rheumatol, Edirne, Turkey. [Pine, Polly] Rigel Pharmaceut, San Francisco, CA USA. [Lucca, Jurandir J. Dalle] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD USA. RP Tsokos, GC (reprint author), Harvard Univ, Sch Med, Dept Med, Div Rheumatol,Beth Israel Deaconess Med Ctr, 330 Brookline Ave,CLS 928, Boston, MA 02115 USA. EM gtsokos@bidmc.harvard.edu OI Lapchak, Peter/0000-0001-8597-088X FU Medical Research and Material Command of the Department of the Army [W81XWH-09-1-0530]; TUBITAK FX Research was supported by Grant W81XWH-09-1-0530 from Medical Research and Material Command of the Department of the Army. O. N. Pamuk was supported by TUBITAK Scholar. NR 34 TC 19 Z9 19 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1857 J9 AM J PHYSIOL-GASTR L JI Am. J. Physiol.-Gastroint. Liver Physiol. PD AUG PY 2010 VL 299 IS 2 BP G391 EP G399 DI 10.1152/ajpgi.00198.2010 PG 9 WC Gastroenterology & Hepatology; Physiology SC Gastroenterology & Hepatology; Physiology GA 633EU UT WOS:000280483200012 PM 20522642 ER PT J AU Mancuso, JD Tobler, SK Eick, AA Keep, LW AF Mancuso, James D. Tobler, Steven K. Eick, Angelia A. Keep, Lisa W. TI Active Tuberculosis and Recent Overseas Deployment in the US Military SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID CLOSED ENVIRONMENT; RISK; ARMY; PERSONNEL; OUTBREAK AB Background: The risk of active TB resulting from military deployment to endemic areas is unknown. It has typically been assumed that the risk of TB approximates the risk among local nationals in that country. Purpose: This nested case-control study assesses the putative association of overseas deployment with active tuberculosis among active-component U.S. military service members. Methods: Deployment histories and other exposures among 578 active TB cases and 2312 controls matched on year of entry into service and length of service between 1990 and 2006 were compared in 2009 using multivariate conditional logistic regression. Multiple imputation methods were used to account for missing data. Results: The matched OR of active TB for military deployers as compared to nondeployers was 1.18 (95% CI=0.91, 1.52). A significant association of deployments of 90-179 days was found, but this was inconsistent with the overall negative result. Significant associations were seen with foreign birth and nonwhite racial or ethnic groups. Overseas stationing in Korea was also found to be associated with active TB. Conclusions: No strong or consistent association was found between active TB and deployment, but an association was seen with long-term residence in TB-endemic countries (Korea). The strongest risk factors for active TB in the U.S. military population were found to exist prior to accession into military service. These conclusions were robust in sensitivity analysis. (Am J Prey Med 2010;39(2):157-163) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Mancuso, James D.] Walter Reed Army Inst Res, Prevent Med Residency Program, Silver Spring, MD 20910 USA. [Tobler, Steven K.; Eick, Angelia A.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Keep, Lisa W.] Uniformed Serv Univ Hlth Sci, Div Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Prevent Med Residency Program, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM james.mancuso@us.army.mil NR 30 TC 13 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD AUG PY 2010 VL 39 IS 2 BP 157 EP 163 DI 10.1016/j.amepre.2010.03.017 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 632MP UT WOS:000280429100007 PM 20621263 ER PT J AU Helou, LB Solomon, NP Henry, LR Coppit, GL Howard, RS Stojadinovic, A AF Helou, Leah B. Solomon, Nancy Pearl Henry, Leonard R. Coppit, George L. Howard, Robin S. Stojadinovic, Alexander TI The Role of Listener Experience on Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) Ratings of Postthyroidectomy Voice SO AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY LA English DT Article DE Consensus Auditory-Perceptual Evaluation of Voice; voice quality; clinical ratings; thyroidectomy ID DIRECT MAGNITUDE ESTIMATION; VISUAL ANALOG SCALE; QUALITY ASSESSMENT; DYSPHONIC VOICE; GRBAS SCALE; RELIABILITY; HYPERNASALITY; JUDGMENTS; SEVERITY AB Purpose: To determine whether experienced and inexperienced listeners rate postthyroidectomy voice samples similarly using the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V). Method: Prospective observational study of voice quality ratings of randomized and blinded voice samples was performed. Twenty-one postthyroidectomy patients' voices, representing a wide range of severities, were rated using a custom-automated version of the CAPE-V. Ten male and 11 female voices were rated by 10 experienced and 10 inexperienced listeners. Experienced listeners consisted of 5 otolaryngologists (ENTs) and 5 speech-language pathologists (SLPs); inexperienced listeners were medical professionals with no formal training or experience in voice disorders. Results: Inexperienced listeners rated voices as more severely impaired than experienced listeners for all CAPE-V parameters (p <= .003). Those without experience in voice disorders had lower intra-and interrater reliability (e. g., r = .838 and .528, respectively, for overall severity) than those with experience in voice disorders (e. g., r = .911 and .722, respectively, for overall severity) for all parameters. Among experienced listeners, ENTs and SLPs rated voices similarly for most parameters. Conclusions: Experienced and inexperienced listeners judged voice quality differently given minimal training with the use of the CAPE-V. SLPs and ENTs rated postthyroidectomy voice quality similarly. These findings indicate that the CAPE-V can be used reliably and similarly by professionals who specialize in voice disorders. C1 [Helou, Leah B.] Univ Pittsburgh, Voice Physiol & Motor Learning Lab, Pittsburgh, PA 15260 USA. [Helou, Leah B.; Solomon, Nancy Pearl; Henry, Leonard R.; Coppit, George L.; Howard, Robin S.; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Helou, LB (reprint author), Univ Pittsburgh, Voice Physiol & Motor Learning Lab, 4033 Forbes Tower, Pittsburgh, PA 15260 USA. EM lbh7@pitt.edu NR 32 TC 13 Z9 15 U1 0 U2 1 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1058-0360 J9 AM J SPEECH-LANG PAT JI Am. J. Speech-Lang. Pathol. PD AUG 1 PY 2010 VL 19 IS 3 BP 248 EP 258 DI 10.1044/1058-0360(2010/09-0012) PG 11 WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation GA 634EW UT WOS:000280563500007 PM 20484704 ER PT J AU Sang, R Kioko, E Lutomiah, J Warigia, M Ochieng, C O'Guinn, M Lee, JS Koka, H Godsey, M Hoel, D Hanafi, H Miller, B Schnabel, D Breiman, RE Richardson, J AF Sang, Rosemary Kioko, Elizabeth Lutomiah, Joel Warigia, Marion Ochieng, Caroline O'Guinn, Monica Lee, John S. Koka, Hellen Godsey, Marvin Hoel, David Hanafi, Hanafi Miller, Barry Schnabel, David Breiman, Robert E. Richardson, Jason TI Rift Valley Fever Virus Epidemic in Kenya, 2006/2007: The Entomologic Investigations SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MOSQUITO SPECIES SUCCESSION; VECTOR COMPETENCE; AEDES-ALBOPICTUS; WEST-AFRICA; RICE FIELDS; OUTBREAK; TRANSMISSION; DIPTERA; EGYPT; MAURITANIA AB In December 2006, Rift Valley fever (RVF) was diagnosed in humans in Garissa Hospital, Kenya and an outbreak reported affecting 11 districts. Entomologic surveillance was performed in four districts to determine the epidemic/epizootic vectors of RVF virus (RVFV). Approximately 297,000 mosquitoes were collected, 164,626 identified to species, 72,058 sorted into 3,003 pools and tested for RVFV by reverse transcription-polymerase chain reaction. Seventy-seven pools representing 10 species tested positive for RVFV, including Aedes mcintoshi/circumluteolus (26 pools), Aedes ochraceus (23 pools), Mansonia uniformis (15 pools); Culex poicilipes, Culex bitaeniorhynchus (3 pools each); Anopheles squamosus, Mansonia africana (2 pools each); Culex quinquefasciatus, Culex univittatus, Aedes pembaensis (1 pool each). Positive Ae. pembaensis, Cx. univittatus, and Cx. bitaeniorhynchus was a first time observation. Species composition, densities, and infection varied among districts supporting hypothesis that different mosquito species serve as epizootic/epidemic vectors of RVFV in diverse ecologies, creating a complex epidemiologic pattern in East Africa. C1 Kenya Govt Med Res Ctr, Ctr Virus Res, Nairobi, Kenya. USAMRU, Nairobi, Kenya. USAMRIID, Frederick, MD USA. Natl Ctr Zoonot Vector Borne & Enter Dis, Div Vector Borne Infect Dis, Ft Collins, CO USA. US Naval Med Res Unit 3, Vector Biol Res Program, Cairo, Egypt. [Breiman, Robert E.] CDC Kenya, Int Emerging Infect Program, Nairobi, Kenya. [Kioko, Elizabeth; Ochieng, Caroline; Koka, Hellen; Schnabel, David] US Army Med Res Inst, Nairobi, Kenya. [O'Guinn, Monica; Lee, John S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Godsey, Marvin; Miller, Barry] Natl Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Hoel, David] USN, Marine Corps Publ Hlth Ctr Detachment, Ctr Med Agr & Vet Entomol, Gainesville, FL USA. [Sang, Rosemary; Lutomiah, Joel; Warigia, Marion] Kenya Med Res Inst KEMRI, Ctr Virus Res, Arbovirol Hemorrhag Fevers Lab, Nairobi, Kenya. [Richardson, Jason] AFRIMS, Bangkok, Thailand. RP Sang, R (reprint author), Kenya Med Res Inst KEMRI, Ctr Virus Res, Arbovirol Hemorrhag Fevers Lab, POB 54628, Nairobi, Kenya. EM rsang@kemri.org; ekioko@wrp-ksm.org; jlutomiah@kemri.org; mwarigia@kemri.org; COchieng@wrp-nbo.org; monica.oguinn@us.army.mil; john.s.lee@us.army.mil; hkoka@wrp-nbo.org; mjg9@cdc.gov; HoelD@NAMRU3.med.navy.mil; Hanafi.Hanafi.eg@med.navy.mil; brm4@cdc.gov; DSchnabel@wrp-nbo.org; Rbreiman@ke.cdc.gov; Jason.Richardson@afrims.org RI Richardson, Jason/A-9441-2011; Valle, Ruben/A-7512-2013 FU GETS; USAMRU-Kenya; Global Disease Detection program; CDC - Kenya; Kenya Medical Research Institute FX This work received financial assistance from GETS program, USAMRU-Kenya, the Global Disease Detection program, CDC - Kenya, and Kenya Medical Research Institute. NR 57 TC 72 Z9 74 U1 0 U2 14 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2010 VL 83 IS 2 SU S BP 28 EP 37 DI 10.4269/ajtmh.2010.09-0319 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 635YS UT WOS:000280694500005 PM 20682903 ER PT J AU Anyamba, A Linthicum, KJ Small, J Britch, SC Pak, E de La Rocque, S Formenty, P Hightower, AW Breiman, RF Chretien, JP Tucker, CJ Schnabel, D Sang, R Haagsma, K Latham, M Lewandowski, HB Magdi, SO Mohamed, MA Nguku, PM Reynes, JM Swanepoel, R AF Anyamba, Assaf Linthicum, Kenneth J. Small, Jennifer Britch, Seth C. Pak, Edwin de La Rocque, Stephane Formenty, Pierre Hightower, Allen W. Breiman, Robert F. Chretien, Jean-Paul Tucker, Compton J. Schnabel, David Sang, Rosemary Haagsma, Karl Latham, Mark Lewandowski, Henry B. Magdi, Salih Osman Mohamed, Mohamed Ally Nguku, Patrick M. Reynes, Jean-Marc Swanepoel, Robert TI Prediction, Assessment of the Rift Valley Fever Activity in East and Southern Africa 2006-2008 and Possible Vector Control Strategies SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID KENYA; VIRUS; HABITATS; AEDES; FORMULATION; CALIFORNIA; VEGETATION; MOSQUITOS; OUTBREAK; DIPTERA AB Historical outbreaks of Rift Valley fever (RVF) since the early 1950s have been associated with cyclical patterns of the El Nino/Southern Oscillation (ENSO) phenomenon, which results in elevated and widespread rainfall over the RVF endemic areas of Africa. Using satellite measurements of global and regional elevated sea surface temperatures, elevated rainfall, and satellite derived-normalized difference vegetation index data, we predicted with lead times of 2-4 months areas where outbreaks of RVF in humans and animals were expected and occurred in the Horn of Africa, Sudan, and Southern Africa at different time periods from September 2006 to March 2008. Predictions were confirmed by entomological field investigations of virus activity and by reported cases of RVF in human and livestock populations. This represents the first series of prospective predictions of RVF outbreaks and provides a baseline for improved early warning, control, response planning, and mitigation into the future. C1 [Anyamba, Assaf; Small, Jennifer; Pak, Edwin; Tucker, Compton J.] NASA, Goddard Space Flight Ctr, Biospher Sci Branch, Greenbelt, MD 20771 USA. [Linthicum, Kenneth J.; Britch, Seth C.] USDA ARS, Ctr Med Agr & Vet Entomol, Gainesville, FL USA. [de La Rocque, Stephane] FAO Food & Agr Org United Nations, Anim Prod & Hlth Div AGAH, EMPRES, Rome, Italy. [Formenty, Pierre] World Hlth Org, Global Alert & Response Dept HSE GAR, Geneva, Switzerland. CDC Kenya Nairobi, Int Emerging Infect Program, Global Dis Detect Div, Nairobi, Kenya. [Chretien, Jean-Paul] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. [Sang, Rosemary] Kenya Govt Med Res Ctr, Ctr Virus Res, Arbovirol VHF Lab, Nairobi, Kenya. [Haagsma, Karl] Youngstown Air Reserve Stn, Vienna, OH USA. [Latham, Mark] Manatee Cty Mosquito Control, Palmetto, FL USA. [Lewandowski, Henry B.] Chatham Cty Mosquito Control, Savannah, GA USA. [Magdi, Salih Osman] Fed Minist Hlth, Dept Epidemiol, Khartoum, Sudan. [Mohamed, Mohamed Ally] Minist Hlth & Social Welf, Dar Es Salaam, Tanzania. Minist Hlth, Div Dis Surveillance & Response, Nairobi, Kenya. [Reynes, Jean-Marc] Inst Pasteur Madagascar, Antananarivo, Madagascar. [Swanepoel, Robert] Natl Inst Communicable Dis, Johannesburg, South Africa. [Hightower, Allen W.; Breiman, Robert F.] CDC, Kenya Med Res Unit KEMRI, Nairobi, Kenya. [Nguku, Patrick M.] Minist Hlth, Div Communicable Dis Control, Nairobi, Kenya. RP Anyamba, A (reprint author), NASA, Goddard Space Flight Ctr, Biospher Sci Branch, Code 614-4, Greenbelt, MD 20771 USA. EM Asaph.Anyamba-1@nasa.gov; kenneth.linthicum@ars.usda.gov; jennifer.1.small@nasa.gov; seth.britch@ars.usda.gov; ed.pak@nasa.gov; Stephane.DeLaRocque@fao.org; formentyp@who.int; awh1@cdc.gov; rbreiman@ke.cdc.gov; jpchretien@gmail.com; compton@ltpmail.gsfc.nasa.gov; DSchnabel@wrp-nbo.org; RSang@kemri.org; Karl.Haagsma@youngstown.af.mil; marklatham@manateemosquito.com; hblewand@chathamcounty.org; mgdosman@yahoo.com; mahd67@yahoo.com; drnguku@yahoo.com; jmreynes@pasteur.mg; bobs@nicd.ac.za RI Valle, Ruben/A-7512-2013; Reynes, Jean-Marc/M-6108-2014 FU United States Army Medical Research Unit-Kenya; Entomology Department; World Health Organization Department of Global Alert and Response; Food and Agricultural Organization of the United Nations; Department of Defense Global Emerging Infections Surveillance and Response System; United States Department of Defense, through the Armed Forces Pest Management Board; National Aeronautics and Space Administration [NNHO8CD31C/ROSES 2007] FX We thank personnel from the Entomological team Arbovirology/VHF Laboratory, Centre for Virus Research Kenya Medical Research Institute, Jason Richardson (now at United States Army Medical Component, Bangkok, Thailand) and various other personnel from the Ministry of Health in Kenya who collected some of the outbreak data used in this study. We also acknowledge the contributions of the United States Army Medical Research Unit-Kenya, Entomology Department, the World Health Organization Department of Global Alert and Response, the Food and Agricultural Organization of the United Nations,The Ministries of Health in Tanzania and Sudan, Institut Pasteur de Madagascar, The United States Department of Agriculture Foreign Agricultural Service for providing access to satellite data used in this study, and the Centers for Disease Control and Prevention Kenya, for access to epidemiological data.; Financial support:The participation of AA, KJL, JS, SCB, EP and CJT on this project is in part supported by funding from the Department of Defense Global Emerging Infections Surveillance and Response System, the United States Department of Agriculture Agricultural Research Service, the Deployed War-Fighter Protection Research Program Funded by the United States Department of Defense, through the Armed Forces Pest Management Board, and the National Aeronautics and Space Administration grant # NNHO8CD31C/ROSES 2007. NR 14 TC 66 Z9 70 U1 4 U2 20 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2010 VL 83 IS 2 SU S BP 43 EP 51 DI 10.4269/ajtmh.2010.09-0289 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 635YS UT WOS:000280694500007 PM 20682905 ER PT J AU Whitman, TJ Coyne, PE Magill, AJ Blazes, DL Green, MD Milhous, WK Buigess, TH Freilich, D Tasker, SA Azar, RG Endy, TP Clagett, CD Deye, GA Shanks, GD Martin, GJ AF Whitman, Timothy J. Coyne, Philip E. Magill, Alan J. Blazes, David L. Green, Michael D. Milhous, Wilbur K. Buigess, Timothy H. Freilich, Daniel Tasker, Sybil A. Azar, Ramzy G. Endy, Timothy P. Clagett, Christopher D. Deye, Gregory A. Shanks, G. Dennis Martin, Gregory J. TI An Outbreak of Plasmodium falciparum Malaria in US Marines Deployed to Liberia SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID WHOLE-BLOOD; MEFLOQUINE; INVITRO; AFRICA; PROPHYLAXIS; METABOLITE; TRAVELERS; CONFLICT; MILITARY; SOMALIA AB In 2003, 44 U S Marines were evacuated from Liberia with either confirmed or presumed Plasmodium falciparum malaria An outbreak investigation showed that only 19 (45%) used insect repellent. 5 (12%) used permethrin-treated clothing. and none used bed netting Adherence with weekly mefloquine (MQ) was reported by 23 (55%) However. only 4 (10%) had serum MO levels high enough to correlate with protection (> 794 ng/mL), and 9 (22%) had evidence of steady-state kinetics (MQ carboxy metabolite/MQ > 3 79). Tablets collected from Marines met USP identity and dissolution specifications for MO Testing failed to identify P falciparum isolates with MO resistance This outbreak resulted from under use of personal protective measures and inadequate adherence with chemophrophylaxis It is essential that all international travelers make malaria prevention measures a priority. especially when embarking to regions of the world with high transmission intensity such as west Africa C1 [Whitman, Timothy J.] Natl Naval Med Ctr, Dept Infect Dis, Div Med, Bethesda, MD 20889 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. Uniformed Serv Univ Hlth Sci, Infect Dis Chin Res Program, Bethesda, MD USA. Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA. Univ S Florida, Coll Publ Hlth, Tampa, FL USA. Naval Med Res Ctr, Silver Spring, MD USA. SUNY Upstate Med Univ, Dept Med, Div Infect Dis, Syracuse, NY USA. USN, Environm & Prevent Med Unit 7, Naples, Italy. Australian Army Malaria Inst, Gallipoli Barracks, Australia. RP Whitman, TJ (reprint author), Natl Naval Med Ctr, Dept Infect Dis, Div Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. NR 41 TC 34 Z9 35 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2010 VL 83 IS 2 BP 258 EP 265 DI 10.4269/ajtmh.2010.09-0774 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 635YQ UT WOS:000280694300008 PM 20682864 ER PT J AU Jatapai, A Nelson, KE Chuenchitra, T Kana, K Eiumtrakul, S Sunantarod, E Rangsin, R AF Jatapai, Anchalee Nelson, Kenrad E. Chuenchitra, Thippawan Kana, Khunakorn Eiumtrakul, Sakol Sunantarod, Ekachai Rangsin, Ram TI Prevalence and Risk Factors for Hepatitis C Virus Infection among Young Thai Men SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEALTH-CARE SETTINGS; INJECTION-DRUG USERS; NORTHERN THAILAND; BLOOD-DONORS; UNSAFE INJECTIONS; DEVELOPING-WORLD; HIV-INFECTION; TRANSMISSION; EPIDEMIOLOGY AB Epidemiologic studies of hepatitis C virus (HCV) infection arc unusual in developing countries. especially Thailand We evaluated the prevalence and risk factors for HCV among military conscripts, including a sample of 5,246 men (1 30 sample). and human immunodeficiency virus (HIV)-1 positive men (N = 500) between 2005 and 2008 The HCV prevalence was 2 2% in the sampled group and 8 4% in HIV-1 sero-positives Among the sampled group. HIV-1 infection. Injection drug use (IDU) history, and unsafe Injections were associated with HCV infection: adjusted prevalence rate ratios [RRs: 95% confidence intervals (CIs)] were 3 7 (1 04-12 77), 1 9 (1 04-3 54), and 1 8 (1 02-3 11), respectively Among HIV-1 sero-positives, an IDU history and residence in southern Thailand were associated with HCV prevalence, adjusted RRs (95% CIs) were 35 (1 71-7.24) and 2 6 (1.18-5.61). respectively Public health measures to prevent HCV in Thailand should focus on reducing injection drug use and other exposures to unsafe injections among young Thai men C1 [Rangsin, Ram] Phramongkutklao Coll Med, Dept Mil & Community Med, Bangkok, Thailand. [Jatapai, Anchalee] Thammasat Univ, Program Biomed Sci, Fac Allied Hlth Sci, Khlong Luang, Pathum Thani, Thailand. [Nelson, Kenrad E.] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Chuenchitra, Thippawan; Kana, Khunakorn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Sunantarod, Ekachai] Army Inst Pathol, Bangkok, Thailand. [Eiumtrakul, Sakol] Royal Thai Army, Bangkok, Thailand. RP Rangsin, R (reprint author), Phramongkutklao Coll Med, Dept Mil & Community Med, Bangkok, Thailand. FU Phramongkutklao Hospital Foundation; National Institutes of Health [1R01TW006972-01A1, R01TW006972-02, 5R01TW006972-03, 5R01TW006972-04]; National Research Council of Thailand FX This study was supported by the Phramongkutklao Hospital Foundation, the National Institutes of Health (Grants 1R01TW006972-01A1, R01TW006972-02, 5R01TW006972-03, and 5R01TW006972-04), and the National Research Council of Thailand NR 36 TC 3 Z9 5 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2010 VL 83 IS 2 BP 433 EP 439 DI 10.4269/ajtmh.2010.09-0749 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 635YQ UT WOS:000280694300039 PM 20682895 ER PT J AU Rice, RD Simon, TE Seery, JM Frizzi, JD Husain, FA Choi, YU AF Rice, Robert D. Simon, Todd E. Seery, Jason M. Frizzi, James D. Husain, Farah A. Choi, Yong U. TI Laparoscopic Sleeve Gastrectomy: Outcomes at a Military Training Center SO AMERICAN SURGEON LA English DT Article ID SUPER-OBESE-PATIENT AB Laparoscopic sleeve gastrectomy (LSG) has gained support as a single-staged and stand-alone bariatric procedure. Reports of excess weight loss of 35 to 83 per cent, reduction in comorbidities, and decreased operative morbidity have garnered support for LSG. This study represents an initial outcome analysis of LSG performed solely at a military treatment center. This study is a retrospective analysis of all patients receiving LSG at Dwight D. Eisenhower Army Medical Center from September 2007 to December 2009. The patients were planned for a stand-alone procedure. One hundred and fifteen patients received LSG over this time period with a mean body mass index of 45.5 +/- 6.2 (range 35.1-58.3). The average age was 47.4 +/- 12.5 years. Diabetes mellitus was seen in 47 per cent and 68 per cent of patients had hypertension. The mean and median length of operation was 124 +/- 48 and 115.5 minutes. The mean percentage of excess weight loss was 16.6 +/- 6.40 per cent at 1 month, 31.5 +/- 7.6 per cent at 3 months, 41.2 +/- 13.9 per cent at 6 months, and 53.7 +/- 12.5 per cent at 1 year from surgery. One or more of patient's preoperative diabetic or hypertensive medications were improved postoperatively in 18.7 per cent and 16.3 per cent, respectively. Incidence of major complications occurred in 4.35 per cent of patients in this study to include four leaks (3.4%), one death (0.87%), and 10 readmissions. Midterm analysis of outcomes related to LSG as a single-stage bariatric procedure is promising as long-term outcome data is collected; the efficacy of this procedure as a sole bariatric procedure will continue to be borne out. C1 [Rice, Robert D.; Simon, Todd E.; Seery, Jason M.; Frizzi, James D.; Husain, Farah A.; Choi, Yong U.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. RP Rice, RD (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM s6rrice@yahoo.com FU Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center FX Research was supported by internal funding from the Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center. NR 14 TC 11 Z9 11 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD AUG PY 2010 VL 76 IS 8 BP 835 EP 840 PG 6 WC Surgery SC Surgery GA 632IW UT WOS:000280417200008 PM 20726413 ER PT J AU Sporty, JLS Lemire, SW Jakubowski, EM Renner, JA Evans, RA Williams, RF Schmidt, JG van der Schans, MJ Noort, D Johnson, RC AF Sporty, Jennifer L. S. Lemire, Sharon W. Jakubowski, Edward M. Renner, Julie A. Evans, Ronald A. Williams, Robert F. Schmidt, Jurgen G. van der Schans, Marcel J. Noort, Daan Johnson, Rudolph C. TI Immunomagnetic Separation and Quantification of Butyrylcholinesterase Nerve Agent Adducts in Human Serum SO ANALYTICAL CHEMISTRY LA English DT Article ID TANDEM MASS-SPECTROMETRY; RETROSPECTIVE DETECTION; SARIN; EXPOSURE; METABOLITES; CHOLINESTERASES; DIGESTION; SOMAN; VX AB A novel method for extracting butyrylcholinesterase (BuChE) from serum as a means of identifying and measuring nerve agent adducts to human BuChE is presented here. Antibutyrylcholinesterase monoclonal antibodies were conjugated to protein-G ferromagnetic particles and mixed with 500 mu L serum samples. The particle-antibody-BuChE product was rinsed and directly digested with pepsin. Native and isotopically enriched nonapeptides corresponding to the pepsin digest products for uninhibited BuChE, and sarin, cyclohexylsarin, VX, and Russian VX nerve agent-inhibited BuChE were synthesized for use as calibrators and internal standards, respectively. Internal standards were added to the filtered digest sample, and the samples were quantified via high performance liquid chromatography-isotope dilution-tandem mass spectrometry. The ratio of adducted to total BuChE nonapeptides was calculated for each nerve agent-exposed serum sample using data collected in a single chromatogram. Nerve agent-inhibited quality control serum pools were characterized as part of method validation; the method was observed to have extremely low background noise. The measurement of both uninhibited and inhibited BuChE peptides compensated for any variations in the pepsin digestion before the internal standard peptide was added to the sample and may prove useful in individualizing patient results following a nerve agent exposure. C1 [Sporty, Jennifer L. S.; Lemire, Sharon W.; Johnson, Rudolph C.] Ctr Dis Control & Prevent, Emergency Response & Air Toxicants Branch, Div Sci Lab, Natl Ctr Environm Hlth, Chamblee, GA 30341 USA. [Jakubowski, Edward M.; Renner, Julie A.; Evans, Ronald A.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Williams, Robert F.; Schmidt, Jurgen G.] Los Alamos Natl Lab, Biosci Div Biosecur & Publ Hlth, Los Alamos, NM 87545 USA. [van der Schans, Marcel J.; Noort, Daan] TNO Def Secur & Safety, Business Unit CBRN Protect, NL-2280 AA Rijswijk, Netherlands. RP Johnson, RC (reprint author), Ctr Dis Control & Prevent, Emergency Response & Air Toxicants Branch, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway,MS F44, Chamblee, GA 30341 USA. EM RMJ6@cdc.gov OI Schmidt, Jurgen/0000-0002-8192-9940 NR 23 TC 47 Z9 48 U1 4 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD AUG 1 PY 2010 VL 82 IS 15 BP 6593 EP 6600 DI 10.1021/ac101024z PG 8 WC Chemistry, Analytical SC Chemistry GA 632DS UT WOS:000280401400040 PM 20617824 ER PT J AU Cohen, SP Williams, KA Kurihara, C Nguyen, C Shields, C Kim, P Griffith, SR Larkin, TM Crooks, M Williams, N Morlando, B Strassels, SA AF Cohen, Steven P. Williams, Kayode A. Kurihara, Connie Nguyen, Conner Shields, Cynthia Kim, Peter Griffith, Scott R. Larkin, Thomas M. Crooks, Matthew Williams, Necia Morlando, Benny Strassels, Scott A. TI Multicenter, Randomized, Comparative Cost-effectiveness Study Comparing 0, 1, and 2 Diagnostic Medial Branch (Facet Joint Nerve) Block Treatment Paradigms before Lumbar Facet Radiofrequency Denervation SO ANESTHESIOLOGY LA English DT Article ID LOW-BACK-PAIN; DOUBLE-BLIND; ZYGAPOPHYSIAL JOINTS; CONTROLLED-TRIAL; CLINICAL-TRIAL; NEUROTOMY; INJECTIONS; EFFICACY; DISC; DISCOGRAPHY AB Background: Among patients presenting with axial low back pain, facet arthropathy accounts for approximately 10-15% of cases. Facet interventions are the second most frequently performed procedures in pain clinics across the United States. Currently, there are no uniformly accepted criteria regarding how best to select patients for radiofrequency denervation. Methods: A randomized, multicenter study was performed in 151 subjects with suspected lumbar facetogenic pain comparing three treatment paradigms. Group 0 received radiofrequency denervation based solely on clinical findings; group 1 underwent denervation contingent on a positive response to a single diagnostic block; and group 2 proceeded to denervation only if they obtained a positive response to comparative blocks done with lidocaine and bupivacaine. A positive outcome was predesignated as >= 50% pain relief coupled with a positive global perceived effect persisting for 3 months. Results: In group 0, 17 patients (33%) obtained a successful outcome at 3 months versus eight patients (16%) in group 1 and 11 (22%) patients in group 2. Denervation success rates in groups 0, 1, and 2 were 33, 39, and 64%, respectively. Pain scores and functional capacity were significantly lower at 3 months but not at 1 month in group 2 subjects who proceeded to denervation compared with patients in groups 0 and 1. The costs per successful treatment in groups 0, 1, and 2 were $6,286, $17,142, and $15,241, respectively. Conclusions: Using current reimbursement scales, these findings suggest that proceeding to radiofrequency denervation without a diagnostic block is the most cost-effective treatment paradigm. C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Williams, Kayode A.] Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD USA. [Kurihara, Connie; Morlando, Benny] Walter Reed Army Med Ctr, Pain Management Div, Anesthesia Serv, Dept Surg, Washington, DC 20307 USA. [Nguyen, Conner] Landstuhl Reg Med Ctr, Phys Med & Rehabil Serv, Dept Surg, Landstuhl, Germany. [Shields, Cynthia; Griffith, Scott R.] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA. [Kim, Peter] Univ So Calif, Sch Med, Dept Anesthesiol, Los Angeles, CA USA. [Griffith, Scott R.] Walter Reed Army Med Ctr, US Army Surg Gen, Washington, DC 20307 USA. [Crooks, Matthew] Univ Calif Los Angeles, UCLA Pain Management Ctr, UCLA Med Ctr, Los Angeles, CA USA. [Williams, Necia] Walter Reed Natl Mil Med Ctr, Combined Anesthesia Serv, Bethesda, MD USA. [Strassels, Scott A.] Univ Texas Austin, Div Pharm Practice, Austin, TX 78712 USA. RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU John P. Murtha Neuroscience and Pain Institute, Johnstown, Pennsylvania; U.S. Army; Army Regional Anesthesia and Pain Medicine Initiative, Washington, D.C. FX Received from the Department of Anesthesiology, Johns Hopkins School of Medicine, Baltimore, Maryland, and Walter Reed Army Medical Center, Washington, D. C. Submitted for publication January 12, 2010. Accepted for publication April 6, 2010. Supported in part by a Congressional Grant from the John P. Murtha Neuroscience and Pain Institute, Johnstown, Pennsylvania; the U.S. Army; and the Army Regional Anesthesia and Pain Medicine Initiative, Washington, D.C. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 48 TC 61 Z9 63 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD AUG PY 2010 VL 113 IS 2 BP 395 EP 405 DI 10.1097/ALN.0b013e3181e33ae5 PG 11 WC Anesthesiology SC Anesthesiology GA 631QX UT WOS:000280363900018 PM 20613471 ER PT J AU Cohen, SP Strassels, SA AF Cohen, Steven P. Strassels, Scott A. TI Different Injectate Volumes in Cervical Medial Branch Blocks: Does Increased Diagnostic Accuracy with Smaller Injectate Volume Lead to Changes in Outcome? Reply SO ANESTHESIOLOGY LA English DT Letter ID PLACEBO-CONTROLLED TRIAL; EFFICACY; PAIN C1 [Cohen, Steven P.] Johns Hopkins Med Inst, Baltimore, MD 21205 USA. [Strassels, Scott A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Cohen, SP (reprint author), Johns Hopkins Med Inst, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu NR 6 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD AUG PY 2010 VL 113 IS 2 BP 499 EP 499 DI 10.1097/ALN.0b013e3181e6a7f3 PG 1 WC Anesthesiology SC Anesthesiology GA 631QX UT WOS:000280363900032 ER PT J AU Fadare, O Lam, S Rubin, C Renshaw, IL Nerby, CL AF Fadare, Oluwole Lam, Suzanne Rubin, Christopher Renshaw, Idris L. Nerby, Craig L. TI Papillary renal cell carcinoma with diffuse clear cells and thyroid-like macrofollicular areas SO ANNALS OF DIAGNOSTIC PATHOLOGY LA English DT Article DE Kidney; Renal cell carcinoma; Clear cell; Papillary; Thyroid follicular ID DIFFERENTIAL-DIAGNOSIS; EPITHELIAL NEOPLASMS; FOLLICULAR CARCINOMA; HISTOLOGIC SUBTYPES; MOLECULAR ANALYSIS; ONCOCYTIC CELLS; FEATURES; KIDNEY; TUMOR; SPECTRUM AB Papillary renal cell carcinoma may display some unusual morphologic variations, including diffuse oncocytic change not otherwise specified, oncocytic change associated with an inverted nuclear pattern or nonoverlapping low-grade nuclei, low-grade spindle cells, and diffuse clear cells. Tumors comprised predominantly of thyroid-like follicles and inspissated eosoinophilic, colloid-like secretions (thyroid-like follicular carcinoma of the kidney) have been recently recognized. We report herein an unusual renal carcinoma that displayed diffuse clear cells, papillary architecture, foamy histiocytes, psammomatous calcifications, and large areas (approximately 20% of tumor volume) with thyroid macrofollicular-like structures and eosinophilic, colloid-like secretions. The tumor was diffusely positive for alpha-methylacyl-CoA racemase, cytokeratin 7 and CD 10, and was entirely negative for CD15, thyroglobulin, thyroid-transcription factor-1, TFE3, and renal cell carcinoma antigen. Fluorescence in situ hybridization using centromeric DNA probes for chromosomes 7, 17, 3, and 3p25 showed gains only in chromosome 7 and no other aberrations. The tumor was accordingly classified as an unusual morphologic variation of papillary renal cell carcinoma. This case affirms the potential for papillary renal cell carcinoma to display a diffuse complement of clear cells, and documents the heretofore unreported finding of large areas of thyroid macrofollicular structures and eosinophilic, colloid-like secretions in this histotype. Published by Elsevier Inc. C1 [Fadare, Oluwole; Lam, Suzanne; Nerby, Craig L.] Lackand Air Force Base, Wilford Hall Med Ctr, Dept Pathol, San Antonio, TX 78236 USA. [Fadare, Oluwole] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Lam, Suzanne] Brooke Army Med Ctr, Dept Pathol & Lab Serv, Ft Sam Houston, TX 78234 USA. [Lam, Suzanne] San Antonio Uniformed Serv Hlth Educ Consortium, Pathol Program, Ft Sam Houston, TX 78236 USA. [Rubin, Christopher; Renshaw, Idris L.] Vanguard Pathol Associates, Austin, TX 73344 USA. RP Fadare, O (reprint author), Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37332 USA. EM oluwolefadare@yahoo.com NR 35 TC 9 Z9 11 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1092-9134 J9 ANN DIAGN PATHOL JI Ann. Diagn. Pathol. PD AUG PY 2010 VL 14 IS 4 BP 284 EP 291 DI 10.1016/j.anndiagpath.2009.09.008 PG 8 WC Pathology SC Pathology GA 631YX UT WOS:000280387900012 PM 20637436 ER PT J AU Summers, SM Scruggs, W Menchine, MD Lahham, S Anderson, C Amr, O Lotfipour, S Cusick, SS Fox, JC AF Summers, Shane M. Scruggs, William Menchine, Michael D. Lahham, Shadi Anderson, Craig Amr, Omar Lotfipour, Shahram Cusick, Seric S. Fox, J. Christian TI A Prospective Evaluation of Emergency Department Bedside Ultrasonography for the Detection of Acute Cholecystitis SO ANNALS OF EMERGENCY MEDICINE LA English DT Article ID SUSPECTED ACUTE CHOLECYSTITIS; RIGHT UPPER QUADRANT; SONOGRAPHIC MURPHY SIGN; PHYSICIANS; ULTRASOUND; GALLBLADDER; PATIENT; DISEASE; UNIT; PAIN AB Study objective: We assess the diagnostic accuracy of emergency physician performed bedside ultrasonography and radiology ultrasonography for the detection of cholecystitis, as determined by surgical pathology. Methods: We conducted a prospective, observational study on a convenience sample of emergency department (ED) patients presenting with suspected cholecystitis from May 2006 to February 2008 Bedside gallbladder ultrasonography was performed by emergency medicine residents and attending physicians at an academic institution Emergency physicians assessed for gallstones, a sonographic Murphy's sign, gallbladder wall thickness, and pericholecystic fluid, and the findings were recorded before formal imaging. The test characteristics of bedside and radiology ultrasonography were determined by comparing their respective results to pathology reports and clinical follow-up at 2 weeks. Results: Of the 193 patients enrolled, 189 were evaluated by bedside ultrasonography Forty-three emergency physicians conducted the ultrasonography, and each physician performed a median of 2 tests. After the bedside ultrasonography, 125 patients received additional radiology ultrasonography. Twenty-six patients underwent cholecystectomy, 23 had pathology-confirmed cholecystitis, and 163 were discharged home to follow-up. Twenty-five were excluded (23 lost to follow-up and 2 unavailable pathology). The test characteristics of bedside ultrasonography were sensitivity 87% (95% confidence interval [Cl] 66% to 97%), specificity 82% (95% Cl 74% to 88%), positive likelihood ratio 4.7 (95% Cl 3 2 to 6.9), negative likelihood ratio 0.16 (95% Cl 0.06 to 0.46), positive predictive value 44% (95% Cl 29% to 59%), and negative predictive value 97% (95% Cl 93% to 99%). The test characteristics of radiology ultrasonography were sensitivity 83% (95% Cl 61% to 95%), specificity 86% (95% Cl 77% to 92%), positive likelihood ratio 5.7 (95% Cl 3.3 to 9.8), negative likelihood ratio 0 20 (95% Cl 0 08 to 0.50), positive predictive value 59% (95% Cl 41% to 76%), and negative predictive value 95% (95% Cl 88% to 99%). Conclusion: The test characteristics of emergency physician performed bedside ultrasonography for the detection of acute cholecystitis are similar to the test characteristics of radiology ultrasonography. Patients with a negative ED bedside ultrasonography result are unlikely to require cholecystectomy or admission for cholecystitis within 2 weeks of their initial presentation [Ann Emerg Med. 2010;56:114-122] C1 [Summers, Shane M.; Scruggs, William; Menchine, Michael D.; Lahham, Shadi; Anderson, Craig; Amr, Omar; Lotfipour, Shahram; Cusick, Seric S.; Fox, J. Christian] Univ Calif Irvine, Dept Emergency Med, Orange, CA 92668 USA. RP Summers, SM (reprint author), Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 33 TC 31 Z9 31 U1 0 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD AUG PY 2010 VL 56 IS 2 BP 114 EP 122 DI 10.1016/j.annemergmed.2010.01.014 PG 9 WC Emergency Medicine SC Emergency Medicine GA 635ZM UT WOS:000280697000008 PM 20138397 ER PT J AU Smith, DR McCarthy, S Chrovian, A Olinger, G Stossel, A Geisbert, TW Hensley, LE Connor, JH AF Smith, Darci R. McCarthy, Sarah Chrovian, Andrew Olinger, Gene Stossel, Andrea Geisbert, Thomas W. Hensley, Lisa E. Connor, John H. TI Inhibition of heat-shock protein 90 reduces Ebola virus replication SO ANTIVIRAL RESEARCH LA English DT Article DE Ebola virus; Hsp90; Therapeutic ID SMALL-MOLECULE INHIBITORS; REVERSE-TRANSCRIPTASE; CHAPERONE MACHINERY; HEMORRHAGIC-FEVER; RNA REPLICATION; HOST FACTOR; HSP90; CELLS; HEAT-SHOCK-PROTEIN-90; POLYMERASE AB Ebola virus (EBOV), a negative-sense RNA virus in the family Filoviridae, is known to cause severe hemorrhagic fever in humans and other primates. Infection with EBOV causes a high mortality rate and currently there is no FDA-licensed vaccine or therapeutic treatment available. Recently, heat-shock protein 90 (Hsp90), a molecular chaperone, was shown to be an important host factor for the replication of several negative-strand viruses. We tested the effect of several different Hsp90 inhibitors including geldanamycin, radicicol, and 17-allylamino-17-demethoxygeldanamycin (17-AAG; a geldanamycin analog) on the replication of Zaire EBOV. Our results showed that inhibition of Hsp90 significantly reduced the replication of EBOV. Classic Hsp90 inhibitors reduced viral replication with an effective concentration at 50% (EC(50)) in the high nanomolar to low micromolar range, while drugs from a new class of Hsp90 inhibitors showed markedly more potent inhibition. These compounds blocked EBOV replication with an EC(50) in the low nanomolar range and showed significant potency in blocking replication in primary human monocytes. These results validated that Hsp90 is an important host factor for the replication of filoviruses and suggest that Hsp90 inhibitors may be therapeutically effective in treating EBOV infection. (C) 2010 Elsevier B.V. All rights reserved. C1 [Geisbert, Thomas W.; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Smith, Darci R.; McCarthy, Sarah; Chrovian, Andrew; Olinger, Gene; Stossel, Andrea; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Connor, JH (reprint author), Boston Univ, Sch Med, Dept Microbiol, 72 E Concord St, Boston, MA 02118 USA. EM jhconnor@bu.edu OI Olinger, Gene/0000-0001-7338-0292; Connor, John/0000-0002-8867-7256 FU DTRA [02-4-4J-081]; NIH [AI064606]; NERCE/BEID [U54 AI057159] FX We thank Josh Johnson and Calli Lear for technical assistance and Diana Fisher for statistical analysis support. The research described herein was sponsored by DTRA; project number 02-4-4J-081, NIH Grant AI064606 and a subcontract from the NERCE/BEID U54 AI057159 awarded to JHC, who is a Peter T. Paul Career Development Professor. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. NR 39 TC 34 Z9 37 U1 3 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD AUG PY 2010 VL 87 IS 2 SI SI BP 187 EP 194 DI 10.1016/j.antiviral.2010.04.015 PG 8 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 639KC UT WOS:000280972700008 PM 20452380 ER PT J AU Montain, SJ Tharion, WJ AF Montain, Scott J. Tharion, William J. TI Hypohydration and muscular fatigue of the thumb alter median nerve somatosensory evoked potentials SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME LA English DT Article DE dehydration; performance; mood; central nervous system; gating ID ADDUCTOR POLLICIS MUSCLE; DEHYDRATION; PERFORMANCE; MOVEMENT; REHYDRATION; RESPONSES; EXERCISE; MICROSTIMULATION; CENTRIFUGAL; CONTRACTION AB The mechanisms by which dehydration impairs endurance performance remain unresolved but may involve alterations in afferent neural processing. The purpose of this study was to determine the effect of hypohydration on somatosensory evoked potentials (SEPs) at rest and during recovery from fatiguing exercise. Fourteen volunteers (12 men, 2 women) performed repetitive isometric thumb contractions (50% maximal voluntary contractions (MVC) and 100% MVC in a 5: 1 ratio, each contraction separated by 5 s of rest) until exhaustion when euhydrated (EU) and when hypohydrated by 4% body mass (HY). SEPs were obtained from the median nerve. The results indicated that HY did not produce statistical differences in time to exhaustion (EU = 754 (SD 255); HY = 714 (SD 318) s; p = 0.66) or rate of muscle fatigue. However, HY was associated with greater subjective feelings of fatigue and loss of vigor after exhaustive exercise (p < 0.01). HY affected N20 latency with an interaction effect of hydration by fatigue state (EU-Rest: 18.5 (SD 1.6) ms; EU-Fatigue: 19.0 (SD 1.6) ms; HY-Rest: 18.3 (SD 1.3) ms; HY-Fatigue: 18.4 (SD 1.5) ms; p = 0.034), but N20 and N20-P22 amplitude responses were similar between HY and EU trials. We concluded that moderate water deficits appear to alter afferent signal processing within the cerebral cortex. C1 [Montain, Scott J.; Tharion, William J.] USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. RP Montain, SJ (reprint author), USA, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM scott.montain@us.army.mil NR 39 TC 10 Z9 11 U1 0 U2 1 PU NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS PI OTTAWA PA BUILDING M 55, OTTAWA, ON K1A 0R6, CANADA SN 1715-5312 J9 APPL PHYSIOL NUTR ME JI Appl. Physiol. Nutr. Metab. PD AUG PY 2010 VL 35 IS 4 BP 456 EP 463 DI 10.1139/H10-032 PG 8 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA 643AZ UT WOS:000281266200003 PM 20725111 ER PT J AU Munir, JA Wu, HY Bauer, K Bindeman, J Byrd, C O'Malley, P Taylor, AJ AF Munir, Jamalah A. Wu, Hongyan Bauer, Kelly Bindeman, Jody Byrd, Carole O'Malley, Patrick Taylor, Allen J. TI Impact of coronary calcium on arterial age and coronary heart disease risk estimation using the MESA arterial age calculator SO ATHEROSCLEROSIS LA English DT Article DE Prevention; Risk factors; Atherosclerosis ID COMPUTED-TOMOGRAPHY; PACC AB Background: We evaluated the impact of arterial age calculation on reclassification of global coronary heart disease risk using the Framingham risk score. Methods: We applied CHD risk factor data from the Prospective Army Coronary Calcium Project to the MESA arterial age calculator (available at http://www.mesa-nhlbi.org). Subjects (N = 1998) were studied with measured CHD risk factors and electron beam computed tomography for the identification of coronary artery calcium. Framingham risk scores (FRS), using the 10-year CHD risk model with and without arterial age, were calculated using the MESA arterial age calculator. Results: The mean FRS of the cohort (42.9 +/- 2.7 years, male gender 82%) was 4.5 +/- 3.6%. Coronary calcium was present in 394 subjects (19.7%). Application of the arterial age calculator increased mean age from 42.9 +/- 2.7 to 43.6 +/- 10.4 years (P < .001), and the mean FRS increased from 4.5 +/- 3.6 to 7.3 +/- 8.1% (P < .001). Reclassification was seen primarily among male subjects, in whom the mean age (chronological vs. arterial age) increased from 42.9 +/- 2.7 to 44.2 +/- 11.0 (P < .001) and the prevalence of high CHD risk increased from 0.6% (10 of 1639) to 10% (165 of 1639; P < .001). Conclusion: Among healthy individuals ages 40-50, application of the MESA arterial age calculator reclassifies 1 in 10 men from low to intermediate risk and 1 in 15 men from low to high risk. Published by Elsevier Ireland Ltd. C1 [Munir, Jamalah A.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Munir, JA (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave,NW,Bldg 2,Room 4A27, Washington, DC 20307 USA. EM Jamalah.munir@amedd.army.mil NR 11 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0021-9150 J9 ATHEROSCLEROSIS JI Atherosclerosis PD AUG PY 2010 VL 211 IS 2 BP 467 EP 470 DI 10.1016/j.atherosclerosis.2010.03.016 PG 4 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 634VC UT WOS:000280612700021 PM 20378115 ER PT J AU Van Driesche, RG Carruthers, RI Center, T Hoddle, MS Hough-Goldstein, J Morin, L Smith, L Wagner, DL Blossey, B Brancatini, V Casagrande, R Causton, CE Coetzee, JA Cuda, J Ding, J Fowler, SV Frank, JH Fuester, R Goolsby, J Grodowitz, M Heard, TA Hill, MP Hoffmann, JH Huber, J Julien, M Kairo, MTK Kenis, M Mason, P Medal, J Messing, R Miller, R Moore, A Neuenschwander, P Newman, R Norambuena, H Palmer, WA Pemberton, R Panduro, AP Pratt, PD Rayamajhi, M Salom, S Sands, D Schooler, S Schwarzlander, M Sheppard, A Shaw, R Tipping, PW van Klinken, RD AF Van Driesche, R. G. Carruthers, R. I. Center, T. Hoddle, M. S. Hough-Goldstein, J. Morin, L. Smith, L. Wagner, D. L. Blossey, B. Brancatini, V. Casagrande, R. Causton, C. E. Coetzee, J. A. Cuda, J. Ding, J. Fowler, S. V. Frank, J. H. Fuester, R. Goolsby, J. Grodowitz, M. Heard, T. A. Hill, M. P. Hoffmann, J. H. Huber, J. Julien, M. Kairo, M. T. K. Kenis, M. Mason, P. Medal, J. Messing, R. Miller, R. Moore, A. Neuenschwander, P. Newman, R. Norambuena, H. Palmer, W. A. Pemberton, R. Panduro, A. Perez Pratt, P. D. Rayamajhi, M. Salom, S. Sands, D. Schooler, S. Schwarzlaender, M. Sheppard, A. Shaw, R. Tipping, P. W. van Klinken, R. D. TI Classical biological control for the protection of natural ecosystems SO BIOLOGICAL CONTROL LA English DT Review DE Invasive species; Ecosystem function; Insect pests; Invasive plants; Ecological restoration; Biological control; Natural ecosystems ID ASPARAGOIDES L. DRUCE; INVASIVE ALIEN PLANTS; FLOATING WEED SALVINIA; SOUTH-AFRICAN FYNBOS; WORLD CLIMBING FERN; ULEX-EUROPAEUS L.; PAPUA-NEW-GUINEA; PARTHENIUM-HYSTEROPHORUS ASTERACEAE; STARTHISTLE CENTAUREA-SOLSTITIALIS; NEOHYDRONOMUS-AFFINIS COLEOPTERA AB Of the 70 cases of classical biological control for the protection of nature found in our review, there were fewer projects against insect targets (21) than against invasive plants (49), in part, because many insect biological control projects were carried out against agricultural pests, while nearly all projects against plants targeted invasive plants in natural ecosystems. Of 21 insect projects, 81% (17) provided benefits to protection of biodiversity, while 48% (10) protected products harvested from natural systems, and 5% (1) preserved ecosystem services, with many projects contributing to more than one goal. In contrast, of the 49 projects against invasive plants, 98% (48) provided benefits to protection of biodiversity, while 47% (23) protected products, and 25% (12) preserved ecosystem services, again with many projects contributing to several goals. We classified projects into complete control (pest generally no longer important), partial control (control in some areas but not others), and "in progress," for projects in development for which outcomes do not yet exist. For insects, of the 21 projects discussed, 62% (13) achieved complete control of the target pest, 19% (4) provided partial control, and 43% (9) are still in progress. By comparison, of the 49 invasive plant projects considered, 27% (13) achieved complete control, while 33% (16) provided partial control, and 49% (24) are still in progress. For both categories of pests, some projects' success ratings were scored twice when results varied by region. We found approximately twice as many projects directed against invasive plants than insects and that protection of biodiversity was the most frequent benefit of both insect and plant projects. Ecosystem service protection was provided in the fewest cases by either insect or plant biological control agents, but was more likely to be provided by projects directed against invasive plants, likely because of the strong effects plants exert on landscapes. Rates of complete success appeared to be higher for insect than plant targets (62% vs 27%), perhaps because most often herbivores gradually weaken, rather than outright kill, their hosts, which is not the case for natural enemies directed against pest insects. For both insect and plant biological control, nearly half of all projects reviewed were listed as currently in progress, suggesting that the use of biological control for the protection of wildlands is currently very active. (C) 2010 Elsevier Inc. All rights reserved. C1 [Van Driesche, R. G.] Univ Massachusetts, PSIS Entomol, Amherst, MA 01003 USA. [Carruthers, R. I.; Smith, L.] USDA ARS, Exot & Invas Weeds Res Unit, Albany, CA 94710 USA. [Center, T.; Pemberton, R.; Pratt, P. D.; Rayamajhi, M.; Tipping, P. W.] ARS, Invas Plant Res Lab, USDA, Ft Lauderdale, FL 33314 USA. [Hoddle, M. S.] Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA. [Hough-Goldstein, J.] Univ Delaware, Newark, DE 19716 USA. [Morin, L.; Sheppard, A.] CSIRO Entomol, Canberra, ACT 2601, Australia. [Wagner, D. L.] Univ Connecticut, Ctr Conservat & Biodivers, Storrs, CT 06269 USA. [Blossey, B.] Cornell Univ, Dept Nat Resources, Ithaca, NY 14853 USA. [Brancatini, V.; Heard, T. A.; Julien, M.; Sands, D.; Schooler, S.; van Klinken, R. D.] CSIRO Entomol, Indooroopilly, Qld 4068, Australia. [Casagrande, R.] Univ Rhode Isl, Dept Plant Sci, Kingston, RI 02881 USA. [Causton, C. E.] Fdn Charles Darwin, Santa Cruz, Galapagos Isl, Ecuador. [Coetzee, J. A.; Hill, M. P.] Rhodes Univ, Dept Zool & Entomol, ZA-6140 Grahamstown, South Africa. [Cuda, J.; Frank, J. H.; Medal, J.] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA. [Ding, J.] Chinese Acad Sci, Invas Ecol & Biocontrol Lab, Wuhan Bot Garden Inst, Wuhan 430074, Hubei, Peoples R China. [Fowler, S. V.] Landcare Res, Lincoln 7640, New Zealand. [Fuester, R.] USDA ARS, Newark, DE 19713 USA. [Goolsby, J.] USDA ARS, Beneficial Insects Res Unit, Weslaco, TX 78596 USA. [Grodowitz, M.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Hoffmann, J. H.] Univ Cape Town, Dept Zool, ZA-7700 Rondebosch, South Africa. [Huber, J.] Nat Resources Canada, AAFC, Ottawa, ON K1A 0C6, Canada. [Kairo, M. T. K.] Florida A&M Univ, Ctr Biol Control, CESTA, Tallahassee, FL 32307 USA. [Kenis, M.] CABI Europe Switzerland, CH-2800 Delemont, Switzerland. [Mason, P.] Agr & Agri Food Canada, Res Ctr, Ottawa, ON K1A 0C6, Canada. [Messing, R.] Univ Hawaii Manoa, Kauai Agr Res Ctr, Kapaa, HI 96746 USA. [Miller, R.; Moore, A.] Univ Guam, Western Pacific Trop Res Ctr, Mangilao, GU USA. [Neuenschwander, P.] Int Inst Trop Agr, Cotonou, Benin. [Newman, R.] Univ Minnesota, St Paul, MN 55108 USA. [Norambuena, H.] INIA Carillanca, Inst Invest Agropecuarias, Temuco, Chile. [Palmer, W. A.] Alan Fletcher Res Stn, Dept Employment, Sherwood, Qld 4075, Australia. [Panduro, A. Perez] Carr Mexico, Colegio Postgraduados, Montecillo, Edo De Mexico, Mexico. [Salom, S.] Virginia Tech, Dept Entomol, Blacksburg, VA 24061 USA. [Shaw, R.] CABI E UK, Surrey TW20 9TY, England. [Schwarzlaender, M.] Univ Idaho, Dept Plant Soil & Entomol Sci, Moscow, ID 83844 USA. RP Van Driesche, RG (reprint author), Univ Massachusetts, PSIS Entomol, Fernald Hall, Amherst, MA 01003 USA. EM vandries@nre.umass.edu RI Julien, Mic/B-6619-2009; van Klinken, Rieks/B-1772-2009; Schooler, Shon/C-1860-2008; Heard, Tim/B-1125-2008; Palmer, William/D-7234-2011; Fowler, Simon/E-5391-2011; Morin, Louise/B-4822-2009; Sheppard, Andy/C-1045-2009 OI van Klinken, Rieks/0000-0002-7578-8977; Shaw, Richard/0000-0003-0805-1841; Heard, Tim/0000-0003-4975-7314; NR 491 TC 57 Z9 57 U1 15 U2 143 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1049-9644 EI 1090-2112 J9 BIOL CONTROL JI Biol. Control PD AUG PY 2010 VL 54 SU 1 BP S2 EP S33 DI 10.1016/j.biocontrol.2010.03.003 PG 32 WC Biotechnology & Applied Microbiology; Entomology SC Biotechnology & Applied Microbiology; Entomology GA 634RT UT WOS:000280602400002 ER PT J AU West, BJ Grigolini, P AF West, B. J. Grigolini, P. TI Chipping away at memory SO BIOLOGICAL CYBERNETICS LA English DT Article DE Memory; Forgetting; Statistics; Renewal process; Chip ID COMPLEX BRAIN NETWORKS; POWER-LAW; 1/F NOISE; FORGETTING CURVES; EMERGENT PROPERTY; HUMAN COGNITION; ORGANIZATION; MODELS; CONNECTIVITY; CLUSTERS AB Inverse power-law behavior is known to be characteristic of adaptation, learning, and memory. Herein, we propose a phenomenological model of forgetting based on renewal theory that introduces a new psychophysical concept, chipping; discrete events that chip away at chunks of memory and thereby produce forgetting. The neural mechanism producing these chips is the 1/f-noise that is generically produced in complex neuronal networks. C1 [West, B. J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Grigolini, P.] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. RP West, BJ (reprint author), USA, Res Off, Res Triangle Pk, NC 27709 USA. EM bruce.j.west@us.army.mil FU US Army Research Office [W911NF-08-1-0177] FX P. Grigolini thanks the US Army Research Office for support of this research W911NF-08-1-0177. NR 38 TC 7 Z9 7 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0340-1200 J9 BIOL CYBERN JI Biol. Cybern. PD AUG PY 2010 VL 103 IS 2 BP 167 EP 174 DI 10.1007/s00422-010-0394-6 PG 8 WC Computer Science, Cybernetics; Neurosciences SC Computer Science; Neurosciences & Neurology GA 627TG UT WOS:000280065200006 PM 20517616 ER PT J AU Fries, D Martini, WZ AF Fries, D. Martini, W. Z. TI Role of fibrinogen in trauma-induced coagulopathy SO BRITISH JOURNAL OF ANAESTHESIA LA English DT Review DE coagulation; transfusion; trauma ID CARDIOPULMONARY BYPASS-SURGERY; FACTOR-XIII ACTIVITY; DILUTIONAL COAGULOPATHY; HYDROXYETHYL STARCH; MAJOR TRAUMA; HYPOTHERMIA; CONCENTRATE; HEMORRHAGE; HEMOSTASIS; PREDICTOR AB Coagulation defects related to severe trauma, trauma-induced coagulopathy (TIC), have a number of causal factors including: major blood loss with consumption of clotting factors and platelets, and dilutional coagulopathy after administration of crystalloids and colloids to maintain blood pressure. In addition, activation of the fibrinolytic system or hyperfibrinolysis, hypothermia, acidosis, and metabolic changes can also affect the coagulation system. All of these directly affect fibrinogen polymerization and metabolism. Other bleeding-related deficiencies usually develop later in massive bleeding related to severe multiple trauma. In major blood loss, fibrinogen reaches a critical value earlier than other procoagulatory factors, or platelets. The question of the critical threshold value is presently the subject of heated debate. A threshold of 100 mg dl(-1) has been recommended, but recent clinical data have shown that at a fibrinogen level of < 150-200 mg dl(-1), there is already an increased tendency to peri- and postoperative bleeding. A high fibrinogen count exerts a protective effect with regard to the amount of blood loss. In multiple trauma patients, priority must be given to early and effective correction of impaired fibrin polymerization by administering fibrinogen concentrate. C1 [Fries, D.] Innsbruck Med Univ, Dept Gen & Surg Crit Care Med, A-6020 Innsbruck, Austria. [Martini, W. Z.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Fries, D (reprint author), Innsbruck Med Univ, Dept Gen & Surg Crit Care Med, Anichstr 35, A-6020 Innsbruck, Austria. EM dietmar.fries@i-med.ac.at FU Astra Zeneca; LFB-France; Pentapharm; CSL Behring FX The authors' laboratory and study group received unrestricted grants and support from Astra Zeneca, LFB-France, Pentapharm, and CSL Behring. NR 46 TC 99 Z9 101 U1 2 U2 10 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0007-0912 J9 BRIT J ANAESTH JI Br. J. Anaesth. PD AUG PY 2010 VL 105 IS 2 BP 116 EP 121 DI 10.1093/bja/aeq161 PG 6 WC Anesthesiology SC Anesthesiology GA 627BT UT WOS:000280013800003 PM 20627882 ER PT J AU Kim, Y Gidwani, A Wyslouzil, BE Sohn, CW AF Kim, Yoojeong Gidwani, Ashok Wyslouzil, Barbara E. Sohn, Chang W. TI Source term models for fine particle resuspension from indoor surfaces SO BUILDING AND ENVIRONMENT LA English DT Article DE Resuspension; Particles; Computational fluid dynamics; Source term; Boundary condition ID TURBULENT AIR-FLOW; WIND-TUNNEL EXPERIMENTS; MICROPARTICLE DETACHMENT; SHEAR-FLOW; DEPOSITION; PLANE; RADIONUCLIDES; MECHANISMS; RESIDENCE; BOUNDARY AB Understanding the dispersion of contaminants inside buildings is important for improving indoor air quality (IAQ). Detailed information on the dispersion profile within a room is required to design active protection systems and to develop countermeasure strategies against potential threats from particulate based agents. A number of computational fluid dynamics (CFD) codes in the public and commercial domain can simulate contaminant dispersion inside a building. One of the critical boundary conditions required by these CFD codes is a resuspension source term model. This paper develops general source term models for particle resuspension from indoor surfaces based on dimensional analysis. First, the physical mechanisms responsible for fine particle resuspension from indoor surfaces are investigated and relevant parameters are identified. Then, three different models are developed using dimensional analysis and published resuspension data in the literature. Finally, the models are evaluated against independent experimental data that were not used to determine the model coefficients. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Kim, Yoojeong] Triton Syst Inc, Chelmsford, MA 01824 USA. [Gidwani, Ashok] CFD Res Corp, Huntsville, AL 35805 USA. [Wyslouzil, Barbara E.] Ohio State Univ, William G Lowrie Dept Chem & Biomol Engn, Columbus, OH 43210 USA. [Sohn, Chang W.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Kim, Y (reprint author), Triton Syst Inc, 200 Turnpike Rd, Chelmsford, MA 01824 USA. EM ykim@tritonsys.com RI Wyslouzil, Barbara/G-8219-2012; OI Wyslouzil, Barbara/0000-0001-9763-5990 FU Joint Science & Technology Office (JSTO) for Chemical and Biological Defense (CBD) through the Army SBIR Phase I [W9132T-07-C-0013] FX A part of this work was funded by the Joint Science & Technology Office (JSTO) for Chemical and Biological Defense (CBD) through the Army SBIR Phase I Contract No. W9132T-07-C-0013. NR 53 TC 18 Z9 18 U1 1 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-1323 J9 BUILD ENVIRON JI Build. Environ. PD AUG PY 2010 VL 45 IS 8 BP 1854 EP 1865 DI 10.1016/j.buildenv.2010.02.016 PG 12 WC Construction & Building Technology; Engineering, Environmental; Engineering, Civil SC Construction & Building Technology; Engineering GA 593XV UT WOS:000277497500013 ER PT J AU Calvano, TP Hospenthal, DR Renz, EM Wolf, SE Murray, CK AF Calvano, Tatjana P. Hospenthal, Duane R. Renz, Evan M. Wolf, Steven E. Murray, Clinton K. TI Central nervous system infections in patients with severe burns SO BURNS LA English DT Article DE Burn; Infection; Central nervous system; Head injury; Meningitis ID ACUTE BACTERIAL-MENINGITIS; ADULTS; SERIES AB Background: Central nervous system (CNS) infections develop in 3-9% of neurosurgical ICU patients and 0.4-2% of all patients hospitalized with head trauma. CNS infection incidence in burn patients is unknown and this study sets out to identify the incidence and risk factors associated with CNS infections. Methods: A retrospective electronic chart review was performed from 1 July 2003 to 30 June 2008 evaluating inpatient medical records along with cerebrospinal fluid (CSF) microbiological results for the presence of CNS infection. The presence of facial and head injuries and burns, along with intracranial interventions were reviewed for association with CNS infections. Results: There were 1964 admissions with 2 patients (0.1%) found to have CNS infection; 1 each with MRSA and Acinetobacter baumannii. Both patients had facial burns and trauma to their head that required intracranial surgery. Of note, both patients had bacteremia with the same microorganisms isolated from their CSF and both survived. Of all patients, 29% had head or neck trauma and burns; 0.35% of those had a CNS infection. Scalp harvest for grafts or debridement of burned scalp was performed on 125 patients of which 9 had an invasive surgical procedure that involved penetration of the skull. The 2 infected patients were from these 9 intracranial surgical patients revealing a 22% infection rate. Conclusion: The incidence of CNS infections in patients with severe burns is extremely low at 0.1%. This rate was low even with head and face burns with trauma unless the patient underwent an intracranial procedure. Published by Elsevier Ltd and ISBI C1 [Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, Ft Sam Houston, TX 78234 USA. [Hospenthal, Duane R.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 18 TC 4 Z9 8 U1 2 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD AUG PY 2010 VL 36 IS 5 BP 688 EP 691 DI 10.1016/j.burns.2009.08.004 PG 4 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 622GM UT WOS:000279649300012 PM 19819633 ER PT J AU Varanasi, C Petry, J Brunke, L Yang, BT Lanter, W Burke, J Wang, H Bulmer, JS Scofield, J Barnes, PN AF Varanasi, C. Petry, J. Brunke, L. Yang, B. T. Lanter, W. Burke, J. Wang, H. Bulmer, J. S. Scofield, J. Barnes, P. N. TI Growth of high-quality carbon nanotubes on free-standing diamond substrates SO CARBON LA English DT Article ID THERMAL INTERFACE MATERIALS; FILMS; ARRAYS; RAMAN; SPECTROSCOPY; ENHANCEMENT; DEVICES AB Carbon nanotubes (CNTs) were grown on diamond-coated Si substrates and free-standing diamond wafers to develop efficient thermal interface materials for thermal management applications. High-quality, translucent, free-standing diamond substrates were processed in a 5 kW microwave plasma chemical vapor deposition (CVD) system using CH(4) as precursor. Ni and Ni-9%W-1.5%Fe catalyst islands were deposited to nucleate CNTs directly onto the diamond substrates. Randomly-oriented multi-walled CNTs forming a mat of similar to 5 mu m thickness and consisting of similar to 20 nm diameter tubes were observed to grow in a thermal CVD system using C(2)H(2) as precursor. Transmission electron microscopy and Raman analyses confirmed the presence of high-quality CNTs on diamond showing a DIG peak ratio of 0.2-0.3 in Raman spectra. Published by Elsevier Ltd. C1 [Varanasi, C.] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Varanasi, C.; Brunke, L.; Burke, J.] Univ Dayton, Res Inst, Dayton, OH 45469 USA. [Lanter, W.] Innovat Sci Solut Inc, Dayton, OH 45440 USA. [Wang, H.] Texas A&M Univ, College Stn, TX 77843 USA. [Petry, J.; Yang, B. T.; Bulmer, J. S.; Scofield, J.; Barnes, P. N.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. RP Varanasi, C (reprint author), USA, Res Off, POB 12211, Res Triangle Pk, NC 27709 USA. EM pani.varanasi@us.army.mil RI Wang, Haiyan/P-3550-2014 OI Wang, Haiyan/0000-0002-7397-1209 FU Air Force Office of Scientific Research; Propulsion Directorate of AFRL FX The authors thank Larry Christy for his assistance in processing some of the samples. The Air Force Office of Scientific Research and the Propulsion Directorate of AFRL provided the financial support of this work. NR 19 TC 8 Z9 8 U1 0 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD AUG PY 2010 VL 48 IS 9 BP 2442 EP 2446 DI 10.1016/j.carbon.2010.03.013 PG 5 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 608LK UT WOS:000278585400008 ER PT J AU Maxwell, AH Rossin, JA AF Maxwell, Amy H. Rossin, Joseph A. TI Effects of airborne contaminant exposure on the physical properties and filtration performance of activated, impregnated carbon SO CARBON LA English DT Article ID DYNAMIC ADSORPTION; WATER-ADSORPTION; SO2 OXIDATION; REMOVAL; FIBERS; AIR; NO2; MECHANISM; OXIDE; ACID AB The effects of airborne contaminant exposure in humid air on the physical properties and filtration capabilities of a copper/zinc/molybdenum impregnated carbon were investigated. The impregnated carbon was exposed individually to CO(2), NH(3) and NO(2) in humid air, then evaluated for changes in metal speciation, metal distribution, porosity and water-uptake. The exposed impregnated carbon was further evaluated for changes in its ability to remove SO(2) and cyclohexane from air streams. Exposure to CO(2) did not impact the physical properties of the impregnated carbon, with changes in filtration performance were not evident. NH(3) exposure resulted in the formation of metal amine complexes, which led to a migration of impregnants from within the pores of the carbon granule to the external surface. NH(3) exposure increased SO(2) filtration while decreasing cyclohexane filtration. The decrease in cyclohexane filtration was attributed to an increase in water uptake and a decrease in porosity. NO(2) exposure significantly decreased the porosity of the carbon substrate while increasing the amount of surface oxygen. The increased surface oxygen greatly increased water uptake. NO(2) exposure greatly reduced the SO(2) breakthrough time and the ability of the material to remove cyclohexane. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Rossin, Joseph A.] Guild Associate, Dublin, OH USA. [Maxwell, Amy H.] USA, ECBC, Aberdeen Proving Ground, MD 21010 USA. RP Rossin, JA (reprint author), Guild Associate, 5750 Shier Rings Rd, Dublin, OH USA. EM jarossin@guildassociates.com NR 29 TC 5 Z9 5 U1 4 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD AUG PY 2010 VL 48 IS 9 BP 2634 EP 2643 DI 10.1016/j.carbon.2010.03.069 PG 10 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 608LK UT WOS:000278585400031 ER PT J AU Ehasson, A AF Ehasson, Arn TI Effect of Continuous Positive Airway Pressure on Inflammatory Markers SO CHEST LA English DT Letter C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Ehasson, A (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD AUG PY 2010 VL 138 IS 2 BP 463 EP 463 DI 10.1378/chest.10-0610 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 636NI UT WOS:000280743600044 ER PT J AU Moawad, FJ Maydonovitch, CL Horwhat, JD Wong, RKH AF Moawad, Fouad J. Maydonovitch, Corinne L. Horwhat, John David Wong, Roy K. H. TI Complications With Pneumatic Dilation SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Letter C1 [Moawad, Fouad J.; Maydonovitch, Corinne L.; Horwhat, John David; Wong, Roy K. H.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD AUG PY 2010 VL 8 IS 8 BP 734 EP 735 DI 10.1016/j.cgh.2010.02.013 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 638YX UT WOS:000280938200021 PM 20202484 ER PT J AU Waxman, AJ Kuehl, M Balakumaran, A Weiss, B Landgren, O AF Waxman, Adam J. Kuehl, Michael Balakumaran, Arun Weiss, Brendan Landgren, Ola TI Smoldering (Asymptomatic) Multiple Myeloma: Revisiting the Clinical Dilemma and Looking Into the Future SO CLINICAL LYMPHOMA MYELOMA & LEUKEMIA LA English DT Review DE Disease classification; Free light chain; M-protein; MGUS; Precursor disease ID UNDETERMINED SIGNIFICANCE MGUS; LENALIDOMIDE PLUS DEXAMETHASONE; MULTIPARAMETER FLOW-CYTOMETRY; INDEPENDENT RISK-FACTOR; IN-SITU HYBRIDIZATION; MARROW PLASMA-CELLS; TOLL-LIKE RECEPTORS; LIGHT-CHAIN RATIO; FACTOR-KAPPA-B; MONOCLONAL GAMMOPATHY AB Recent studies show that multiple myeloma (MM) is consistently preceded by an asymptomatic precursor state. Smoldering MM (SMM) is a MM precursor defined by an M-protein concentration >= 3 g/dL and/or >= 10% bone marrow plasma cells, in the absence of end-organ damage. Compared with individuals diagnosed with monoclonal gammopathy of undetermined significance (MGUS), patients with SMM have a much higher annual risk of developing MM. However, based on clinical observations, the natural history of SMM varies greatly, from stable MGUS-like disease to highly progressive disease. Using conventional clinical markers, SMM patients can be stratified into 3 risk groups. Importantly, because of considerable molecular heterogeneity, we currently lack reliable markers to predict prognosis for individual SMM patients. Furthermore, until recently, potent drugs with reasonable toxicity profiles have not been available for the development of early MM treatment strategies. Consequently, current clinical guidelines emphasize the application of close clinical monitoring followed by treatment when the patient develops symptomatic MM. This review focuses on novel biomarkers, molecular profiles, and microenvironmental interactions of interest in myelomagenesis. We also discuss how the integration of novel biologic markers and clinical monitoring of SMM could facilitate the development of early treatment strategies for high-risk SMM patients in the future. C1 [Landgren, Ola] NCI, NIH, Ctr Canc Res, Med Oncol Branch, Bethesda, MD 20892 USA. [Waxman, Adam J.] NIH Clin Ctr, Clin Res Training Program, Bethesda, MD USA. [Kuehl, Michael] NCI, Genet Branch, Bethesda, MD 20892 USA. [Balakumaran, Arun] Natl Inst Dent & Craniofacial Res, Bethesda, MD USA. [Weiss, Brendan] Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, Washington, DC 20307 USA. RP Landgren, O (reprint author), NCI, NIH, Ctr Canc Res, Med Oncol Branch, 9000 Rockville Pike,Bldg 10 Rm 13N240, Bethesda, MD 20892 USA. EM landgreo@mail.nih.gov FU National Cancer Institute of the National Institutes of Health; The Binding Site, Inc.; National Institutes of Health; Pfizer Inc. FX This work was supported by the Intramural Research Program of the National Cancer Institute of the National Institutes of Health.; The authors have no relevant relationships to disclose. Dr. Weiss receives research support from The Binding Site, Inc. Adam Waxman is a student in the Clinical Research Training Program at the National Institutes of Health which is made possible through a public-private partnership supported jointly by the National Institutes of Health intramural research program and a grant to the Foundation for NIH from Pfizer Inc. NR 103 TC 16 Z9 17 U1 0 U2 4 PU CIG MEDIA GROUP, LP PI DALLAS PA 3500 MAPLE AVENUE, STE 750, DALLAS, TX 75219-3931 USA SN 2152-2650 EI 2152-2669 J9 CL LYMPH MYELOM LEUK JI Clin. Lymphoma Myeloma Leuk. PD AUG PY 2010 VL 10 IS 4 BP 248 EP 257 DI 10.3816/CLML.2010.n.053 PG 10 WC Oncology; Hematology SC Oncology; Hematology GA 634OK UT WOS:000280592400002 PM 20709660 ER PT J AU Yao, B Hofmeister, C Patterson, T Sohn, YH van den Bergh, M Delahanty, T Cho, K AF Yao, Bo Hofmeister, Clara Patterson, Travis Sohn, Yong-ho van den Bergh, Mark Delahanty, Tim Cho, Kyu TI Microstructural features influencing the strength of Trimodal Aluminum Metal-Matrix-Composites SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Metal-Matrix-Composites (MMCs); Microstructure; Microscopy; Powder processing ID ULTRAFINE-GRAINED METALS; NANOSTRUCTURED MATERIALS; DISLOCATION GENERATION; MECHANICAL-BEHAVIOR; DUCTILITY; NANOCRYSTALLINE; ALLOY; DEFORMATION; TEMPERATURE AB Trimodal Al Metal-Matrix-Composites (MMCs), consisting of a nanocrystalline Al phase (NC-Al), B(4)C reinforcement particles, and a coarse-grain Al phase (CG-Al), were successfully fabricated on both lab and commercial scales. Multi-scale microstructural features contributing to the exceptional high strength of Trimodal Al MMCs were examined via comprehensive microstructural and spectroscopic analysis. Size and distribution of nanocrystalline Al grains, B(4)C particles, coarse-grain Al, and uniformity in distribution were examined and quantified. Other features such as dispersoids with and without nitrogen (e.g., Al(2)O(3), Al(4)C(3)), dislocation density, and interfacial characteristics were also examined with due respect for their contributions to the strength of Trimodal Al MMCs. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Yao, Bo; Hofmeister, Clara; Patterson, Travis; Sohn, Yong-ho] Univ Cent Florida, Dept Mech Mat & Aerosp Engn, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. [van den Bergh, Mark] DWA Aluminum Composites, Chatsworth, CA 91311 USA. [Delahanty, Tim] Pittsburgh Mat Technol Inc, Jefferson Hills, PA 15025 USA. [Cho, Kyu] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Sohn, YH (reprint author), Univ Cent Florida, Dept Mech Mat & Aerosp Engn, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. EM ysohn@mail.ucf.edu RI Sohn, Yongho/A-8517-2010; Yao, Bo/C-9927-2011 OI Sohn, Yongho/0000-0003-3723-4743; FU US Army Research Laboratory [W911NF-08-2-0026] FX The Materials Characterization Facility (MCF) at the University of Central Florida (UCF) and assistance from engineers at MCF are gratefully acknowledged. Research was sponsored by US Army Research Laboratory and was accomplished under Cooperative Agreement W911NF-08-2-0026. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 36 TC 25 Z9 26 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD AUG PY 2010 VL 41 IS 8 BP 933 EP 941 DI 10.1016/j.compositesa.2010.02.013 PG 9 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA 614ZA UT WOS:000279097200002 ER PT J AU Dongare, AM Rajendran, AM LaMattina, B Zikry, MA Brenner, DW AF Dongare, Avinash M. Rajendran, Arunachalam M. LaMattina, Bruce Zikry, Mohammed A. Brenner, Donald W. TI Tension-compression asymmetry in nanocrystalline Cu: High strain rate vs. quasi-static deformation SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Molecular dynamics; Nanocrystalline metals; Tension-compression asymmetry; Plastic deformation ID STRENGTH; METALS; COPPER AB Large-scale molecular dynamics (MD) simulations are used to understand the yield behavior of nanocrystalline Ni and Cu with grain sizes <= 10 nm at high strain rates. The calculated flow stress values at a strain rate of 10(9) s(-1) suggest an asymmetry in the strength values in tension and compression with the nanocrystalline metal being stronger in compression than in tension. This tension-compression strength asymmetry is observed to decrease with a decrease in grain size of the nanocrystalline metal up to a grain size of 4 nm, after which, a further decrease in grain size results in an increase in the strength asymmetry. The effect of strain rate on the yield behavior of nanocrystalline metals as obtained from MD simulations is discussed and compared with that reported in the literature obtained by molecular statics simulations for quasi-static loading conditions. (C) 2010 Elsevier B.V. All rights reserved. C1 [Dongare, Avinash M.; Brenner, Donald W.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Dongare, Avinash M.; Zikry, Mohammed A.] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. [Rajendran, Arunachalam M.] Univ Mississippi, Dept Mech Engn, University, MI USA. [LaMattina, Bruce] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Dongare, AM (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM amdongare@ncsu.edu RI Brenner, Donald/D-1741-2009; Dongare, Avinash/A-3470-2009; OI Dongare, Avinash/0000-0003-3189-3588 FU US Army Research Office (ARO); National Science Foundation [DMR-03,04,299, DMR-08,06,323] FX AMD is supported by the US Army Research Office (ARO) through the National Research Council Research Associateship Program. DWB and MAZ are also supported by the National Science Foundation through Grants DMR-03,04,299 and DMR-08,06,323. Any opinions, findings, and conclusions or recommendations expressed in this paper are those of the authors and do not necessarily reflect the views of the National Science Foundation or other funding agencies. NR 17 TC 11 Z9 11 U1 0 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 J9 COMP MATER SCI JI Comput. Mater. Sci. PD AUG PY 2010 VL 49 IS 2 BP 260 EP 265 DI 10.1016/j.commatsci.2010.05.004 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA 640CR UT WOS:000281025900010 ER PT J AU Rickards, CA Ryan, KL Ludwig, DA Convertino, VA AF Rickards, Caroline A. Ryan, Kathy L. Ludwig, David A. Convertino, Victor A. TI Is heart period variability associated with the administration of lifesaving interventions in individual prehospital trauma patients with normal standard vital signs? SO CRITICAL CARE MEDICINE LA English DT Article DE R-R interval; heart rate; heart period variability; trauma; decision support; triage ID DIMINISHED PHYSIOLOGICAL RESERVE; RATE COMPLEXITY; POINCARE PLOT; REMOTE TRIAGE; MORTALITY; DEATH; PREDICTION; INDICATOR; DYNAMICS; CAUTIONS AB Objective: To determine whether heart period variability provides added value in identifying the need for lifesaving interventions (LSI) in individual trauma patients with normal standard vital signs upon early medical assessment. Design: Retrospective database review. Setting: Helicopter transport to Level 1 trauma center and first 24 hrs of in-hospital care. Patients: Prehospital trauma patients requiring helicopter transport to Level 1 trauma center. Measurements and Main Results: Heart period variability was analyzed from electrocardiographic recordings collected from 159 prehospital trauma patients with normal standard vital signs (32 LSI patients, 127 No-LSI patients). Although 13 of the electrocardiogram derived metrics demonstrated simple (i.e., univariate) discrimination between groups, at the multivariate level, only fractal dimension by curve length (FD-L) was uniquely associated with group membership (LSI vs. No-LSI, p = .0004). Whereas the area under the receiver operating characteristics curve for FD-L was 0.70, the overall correct classification rate (true positives and true negatives) of 82% was only 2% higher than the baseline prediction rate of 80% (i.e., no information except for the known proportion of overall No-LSI cases, 127 of 159 patients). Furthermore, 84% of the individual FD-L values for the LSI group were within the range of the No-LSI group. Conclusions: Only FD-L was uniquely able to distinguish patient groups based on mean values when standard vital signs were normal. However, the accuracy of FD-L in distinguishing between patients was only slightly better than the baseline prediction rate. There was also very high overlap of individual heart period variability values between groups, so many LSI patients could be incorrectly classified as not requiring an LSI if a single heart period variability value was used as a triage tool. Based on this analysis, heart period variability seems to have limited value for prediction of LSIs in prehospital trauma patients with normal standard vital signs. (Crit Care Med 2010; 38: 1666-1673) C1 [Rickards, Caroline A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. [Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Ludwig, David A.] Univ Miami, Sch Med, Dept Pediat, Div Clin Res, Miami, FL USA. RP Rickards, CA (reprint author), Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. EM caroline.rickards@us.army.mil FU U.S. Army Combat Casualty Care FX This research was supported, in part, by the U.S. Army Combat Casualty Care Research Program. NR 39 TC 17 Z9 17 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD AUG PY 2010 VL 38 IS 8 BP 1666 EP 1673 DI 10.1097/CCM.0b013e3181e74cab PG 8 WC Critical Care Medicine SC General & Internal Medicine GA 628JU UT WOS:000280116500006 PM 20562705 ER PT J AU Batchinsky, AI Cancio, LC Buchman, TG AF Batchinsky, Andriy I. Cancio, Leopoldo C. Buchman, Timothy G. TI Half empty or half full? SO CRITICAL CARE MEDICINE LA English DT Editorial Material ID HEART-RATE COMPLEXITY; TRAUMA PATIENTS; LIFESAVING INTERVENTIONS; PREDICTION; VARIABILITY; MORTALITY; ENTROPY C1 [Batchinsky, Andriy I.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Buchman, Timothy G.] Emory Ctr Crit Care, Atlanta, GA USA. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. OI Buchman, Timothy/0000-0001-7350-5921 NR 15 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD AUG PY 2010 VL 38 IS 8 BP 1747 EP 1748 DI 10.1097/CCM.0b013e3181e94230 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 628JU UT WOS:000280116500018 PM 20647803 ER PT J AU Conti, G Bratus, S Shubina, A Sangster, B Ragsdale, R Supan, M Lichtenberg, A Perez-Alemany, R AF Conti, Gregory Bratus, Sergey Shubina, Anna Sangster, Benjamin Ragsdale, Roy Supan, Matthew Lichtenberg, Andrew Perez-Alemany, Robert TI Automated mapping of large binary objects using primitive fragment type classification SO DIGITAL INVESTIGATION LA English DT Article; Proceedings Paper CT 10th Annual DFRWS Conference CY AUG 02-04, 2010 CL Portland, OR DE Binary mapping; Binary analysis; File carving; Hex editors; Classification; Reverse engineering AB Security analysts, reverse engineers, and forensic analysts are regularly faced with large binary objects, such as executable and data files, process memory dumps, disk images and hibernation files, often Gigabytes or larger in size and frequently of unknown, suspect, or poorly documented structure. Binary objects of this magnitude far exceed the capabilities of traditional hex editors and textual command line tools, frustrating analysis. This paper studies automated means to map these large binary objects by classifying regions using a multi-dimensional, information-theoretic approach. We make several contributions including the introduction of the binary mapping metaphor and its associated applications, as well as techniques for type classification of low-level binary fragments. We validate the efficacy of our approach through a series of classification experiments and an analytic case study. Our results indicate that automated mapping can help speed manual and automated analysis activities and can be generalized to incorporate many low-level fragment classification techniques. (C) 2010 Digital Forensic Research Workshop. Published by Elsevier Ltd. All rights reserved. C1 [Conti, Gregory; Sangster, Benjamin; Ragsdale, Roy; Supan, Matthew; Perez-Alemany, Robert] US Mil Acad, West Point, NY 10996 USA. [Bratus, Sergey; Shubina, Anna] Dartmouth Coll, ISTS, Hanover, NH 03755 USA. [Lichtenberg, Andrew] Skidmore Coll, Saratoga Springs, NY 12866 USA. RP Conti, G (reprint author), US Mil Acad, West Point, NY 10996 USA. EM gregory-conti@us.army.mil; sergey@cs.dartmouth.edu; ashubina@cs.dartmouth.edu; benjamin.sangster@us.army.mil; roy.ragsdale@us.army.mil; matthew.supan@us.army.mil; alichten@skidmore.edu; robert.perezalemany@us.army.mil NR 22 TC 13 Z9 14 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-2876 J9 DIGIT INVEST JI Digit. Investig. PD AUG PY 2010 VL 7 SU 1 BP S3 EP S12 DI 10.1016/j.diin.2010.05.002 PG 10 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Computer Science GA 639XP UT WOS:000281010700002 ER PT J AU Tipping, PW Martin, MR Bauer, L Pokorny, E Center, TD AF Tipping, Philip W. Martin, Melissar R. Bauer, Laurie Pokorny, Eileen Center, Ted D. TI Asymmetric impacts of two herbivore ecotypes on similar host plants SO ECOLOGICAL ENTOMOLOGY LA English DT Article DE Cyrtobagous salviniae; ecotype; local adaptation; Salvinia minima; Salvinia molesta ID FLOATING WEED SALVINIA; BIOLOGICAL-CONTROL; PHENOTYPIC PLASTICITY; CYRTOBAGOUS-SALVINIAE; HUSTACHE COLEOPTERA; RAPID EVOLUTION; MOLESTA; SIZE; ECOSYSTEMS; CURCULIONIDAE AB 1. Ecotypes may arise following allopatric separation from source populations. The simultaneous transfer of an exotic plant to a novel environment, along with its stenophagous herbivore, may complicate more traditional patterns of divergence from the plant and insect source populations. 2. The present study evaluated herbivory effects by two Cyrtobagous salviniae ecotypes on two species of Salvinia: the larger S. molesta and the smaller S. minima. Evaluations were based on relative growth rates, biomass production, coverage, and nutrient cycling in a series of complementary and comparative laboratory and outdoor tank experiments. 3. In general, the experiment results indicated that the smaller Florida ecotype of C. salviniae impacted both Salvinia species more than the larger Brazil ecotype. Herbivory, especially by the Florida ecotype, also improved water quality and accelerated nutrient cycling by increasing the rates of litterfall from the standing crops of salvinia. 4. The smaller size of the Florida ecotype may be adaptive by allowing maximal exploitation of host plants via internal larval feeding, which presumably reduces predation risk while increasing damage to the plant. These findings provide support for relying on the suppressive effects of the Florida ecotype in Florida, rather than introducing the Brazil ecotype to counter new infestations of S. molesta. C1 [Tipping, Philip W.; Pokorny, Eileen; Center, Ted D.] ARS, USDA, Invas Plant Res Lab, Ft Lauderdale, FL 33314 USA. [Martin, Melissar R.] USA, Corps Engineers, Miami, FL USA. [Bauer, Laurie] Natl Ocean & Atmospher Adm, Ctr Coast Monitoring & Assessment, Silver Spring, MD USA. RP Tipping, PW (reprint author), ARS, USDA, Invas Plant Res Lab, Ft Lauderdale, FL 33314 USA. EM philip.tipping@ars.usda.gov NR 51 TC 5 Z9 5 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0307-6946 J9 ECOL ENTOMOL JI Ecol. Entomol. PD AUG PY 2010 VL 35 IS 4 BP 469 EP 476 DI 10.1111/j.1365-2311.2010.01203.x PG 8 WC Entomology SC Entomology GA 619PA UT WOS:000279440900008 ER PT J AU Kessler, C Tristano, JM De Lorenzo, R AF Kessler, Chad Tristano, Jenny M. De Lorenzo, Robert TI The Emergency Department Approach to Syncope: Evidence-based Guidelines and Prediction Rules SO EMERGENCY MEDICINE CLINICS OF NORTH AMERICA LA English DT Article DE Syncope; Emergency department; Guidelines; San Francisco Syncope Rule ID RISK STRATIFICATION; MANAGEMENT DIAGNOSIS; SHORT-TERM; PROSPECTIVE VALIDATION; UNEXPLAINED SYNCOPE; HOSPITAL ADMISSION; AMERICAN-COLLEGE; SERIOUS OUTCOMES; OF-CARDIOLOGY; UPDATE 2004 AB Syncope is a sudden, transient loss of consciousness associated with inability to maintain postural tone followed by spontaneous recovery and return to baseline neurologic status. Global cerebral hypoperfusion is the final pathway common to all presentations of syncope, but this symptom presentation has a broad differential diagnosis. It is important to identify patients whose syncope is a symptom of a potentially life-threatening condition. This article reviews the current status of syncope from the emergency department perspective, focusing on the current evidence behind the various clinical decision rules derived during the past decade. C1 [Kessler, Chad] Jesse Brown VA Hosp, Dept Emergency Med, Chicago, IL 60612 USA. [Kessler, Chad] Univ Illinois, Sch Med Chicago, Dept Internal Med, Chicago, IL 60612 USA. [Kessler, Chad] Univ Illinois, Sch Med Chicago, Dept Emergency Med, Chicago, IL 60612 USA. [Tristano, Jenny M.] Univ Illinois, Dept Emergency Med Residency Program, Chicago, IL 60612 USA. [De Lorenzo, Robert] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [De Lorenzo, Robert] Brooke Army Med Ctr, MCHE CI, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Kessler, C (reprint author), Jesse Brown VA Hosp, Dept Emergency Med, 820 S Damen Ave,MC 111, Chicago, IL 60612 USA. NR 49 TC 11 Z9 11 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0733-8627 J9 EMERG MED CLIN N AM JI Emerg. Med. Clin. N. Am. PD AUG PY 2010 VL 28 IS 3 BP 487 EP + DI 10.1016/j.emc.2010.03.014 PG 15 WC Emergency Medicine SC Emergency Medicine GA 649AN UT WOS:000281737700006 PM 20709240 ER PT J AU Zakhashvili, K Tsertsvadze, N Chikviladze, T Jghenti, E Bekaia, M Kuchuloria, T Hepburn, MJ Imnadze, P Nanuashvili, A AF Zakhashvili, Khatuna Tsertsvadze, Nikoloz Chikviladze, Tamar Jghenti, Ekaterine Bekaia, Marekhi Kuchuloria, Tinatin Hepburn, Matthew J. Imnadze, Paata Nanuashvili, Alexander TI Crimean-Congo Hemorrhagic Fever in Man, Republic of Georgia, 2009 SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID NOSOCOMIAL OUTBREAK C1 [Zakhashvili, Khatuna; Tsertsvadze, Nikoloz; Chikviladze, Tamar; Jghenti, Ekaterine; Imnadze, Paata] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Bekaia, Marekhi] O Ghudushauri Natl Med Ctr, Tbilisi, Rep of Georgia. [Kuchuloria, Tinatin; Imnadze, Paata] I Javakhishvili Tbilisi State Univ, Tbilisi, Rep of Georgia. [Kuchuloria, Tinatin] Technol Management Co, Tbilisi, Rep of Georgia. [Hepburn, Matthew J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Nanuashvili, Alexander] Serv Antimicrobial Chemotherapy Georgia, Tbilisi, Rep of Georgia. RP Imnadze, P (reprint author), Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. EM pimnadze@ncdc.ge NR 8 TC 14 Z9 15 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD AUG PY 2010 VL 16 IS 8 BP 1326 EP 1328 DI 10.3201/eid1608.100181 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 632TX UT WOS:000280452600030 PM 20678341 ER PT J AU Knight, MA Harris, MC Van Cleave, BE Hockenberry, AN AF Knight, Michael A. Harris, Mark C. Van Cleave, Bobby E. Hockenberry, Adam N. TI Seepage Remediation and Karst Foundation Treatment at Clearwater Dam, Piedmont, Missouri SO ENVIRONMENTAL & ENGINEERING GEOSCIENCE LA English DT Article DE Dams; Karst; Permeation Grouting; Foundations AB Following the detection of a sinkhole in the upstream face of Clearwater Dam in January 2003, substantial efforts have been completed to explore and pre-treat the dam foundation in preparation for construction of a "hanging'' cutoff wall that will complete the seepage remediation program. Initial phases of pre-treatment started in 2004 and included core drilling and placement of both low- and high-mobility grouts in the immediate vicinity of the sinkhole. This work preceded the more extensive efforts that were completed in the fall of 2009. The recently completed project was primarily a downstage, high-mobility grouting effort involving approximately 840 boreholes in two lines along the 4,225-ft-long embankment. In addition, the project also included treatment of an extensive epikarst zone and placement of low- mobility and sanded grout mixes in selected problematic locations. High initial epikarst and bedrock permeability ranging from 20 to 200 Lugeon was reduced using systematic grouting approaches focused toward achieving a pre-treatment target of 10 Lugeon within the vertical limits of the proposed cutoff wall and a 3-Lugeon target beneath the proposed cutoff wall. Pervasive solution-enhanced bedrock fractures resulting from repeated tectonic uplift and sub-aerial exposure set forth challenging conditions in the face of the pre-treatment objectives. Against this baseline condition, the recent grouting efforts have set the stage for construction of a cutoff wall and completion of the Clearwater Dam Major Rehabilitation Project. C1 [Knight, Michael A.; Hockenberry, Adam N.] Gannett Fleming Inc, Harrisburg, PA 17106 USA. [Harris, Mark C.; Van Cleave, Bobby E.] USA, Corps Engineers, Little Rock, AR USA. RP Knight, MA (reprint author), Gannett Fleming Inc, POB 67100, Harrisburg, PA 17106 USA. EM mknight@gfnet.com NR 23 TC 2 Z9 2 U1 1 U2 8 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1078-7275 J9 ENVIRON ENG GEOSCI JI Environ. Eng. Geosci. PD AUG PY 2010 VL 16 IS 3 BP 195 EP 210 PG 16 WC Engineering, Environmental; Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 649BY UT WOS:000281743000003 ER PT J AU Greene, BH Crock, J Moskovitz, L Premozic, JW AF Greene, Brian H. Crock, Jennifer Moskovitz, Larry Premozic, Joseph W. TI Evaluation of Seepage, Internal Erosion, and Remedial Alternatives for East Branch Dam, Elk County, Pennsylvania SO ENVIRONMENTAL & ENGINEERING GEOSCIENCE LA English DT Article DE Embankment Dam; Internal Erosion; Seepage; Remediation AB East Branch Dam is a Pittsburgh District U. S. Army Corps of Engineers (COE) dam that nearly failed in 1957, several years after construction. The dam is a zoned embankment that is 56 m (184 ft) high and 526 m (1,725 ft) long. Its primary purpose is flood control. Following the observation of muddy water flowing from a rock drain at the downstream toe of the dam, soon after construction, emergency drilling through the embankment exposed a void that demanded lowering the pool and subsequent grouting. Localized grouting was accomplished to treat the void but did not involve a comprehensive repair of the dam. The 1957 near failure of East Branch Dam represents an excellent case history that provides dam designers and operators today insight into the mechanisms of internal erosion within an embankment dam, and it underscores the need to quickly take all necessary actions to protect the public. Since the 1957 emergency, the project has performed satisfactorily and has been closely monitored with a network of piezometers, weirs, and alignment-settlement pins. Even though evidence of further internal erosion has not reappeared, the fundamental conditions that caused the original problem were not corrected by the 1957 emergency repairs. Recently, the dam was evaluated under the COE Screening Portfolio Risk Assessment (SPRA) program. In light of the 1957 incident, conditions of active seepage, and high phreatic pressures within the embankment, the SPRA program assigned East Branch a Dam Safety Action Classification (DSAC) rating of II, generally indicating that failure could begin during normal operations or be initiated as the consequence of an event. A potential failure mode analysis (PFMA) was conducted in 2008 by the U. S. Bureau of Reclamation (USBR) as requested and participated in by the Pittsburgh District. The PMFA identified the potential for re-initiation of internal erosion at or near the cavity repair as the highest risk failure mode and a primary threat to public safety. Given these findings, the Pittsburgh District implemented a set of non-structural interim risk reduction measures (IRRM) in February 2008, including lowering of the pool to reduce risk of failure by an estimated 60 percent. The interim measures will allow the dam to operate safely until the COE determines the appropriate long-term remedy to address the structural deficiencies of East Branch Dam. In 2009, a joint COE-USBR PFMA was undertaken using procedures from both agencies. Current dam safety efforts involve reassessing potential failure modes, preparing a Dam Safety Modification Report, evaluating various remedial alternatives, and recommending a long-range repair plan for East Branch Dam. This paper examines the history of the dam, investigations performed, potential failure modes examined, and the range of remedial alternatives being considered. C1 [Greene, Brian H.; Crock, Jennifer; Moskovitz, Larry; Premozic, Joseph W.] USA, Corps Engineers, Pittsburgh, PA 15222 USA. RP Greene, BH (reprint author), USA, Corps Engineers, 1000 Liberty Ave, Pittsburgh, PA 15222 USA. NR 9 TC 1 Z9 1 U1 4 U2 14 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1078-7275 J9 ENVIRON ENG GEOSCI JI Environ. Eng. Geosci. PD AUG PY 2010 VL 16 IS 3 BP 229 EP 243 PG 15 WC Engineering, Environmental; Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 649BY UT WOS:000281743000005 ER PT J AU Michael, PR Richmond, MW Superfesky, MJ Stump, DE Chavel, LK AF Michael, Peter R. Richmond, Michael W. Superfesky, Michael J. Stump, Donald E., Jr. Chavel, Lisa K. TI Potential of Breakthroughs of Impounded Coal Refuse Slurry into Underground Mines SO ENVIRONMENTAL & ENGINEERING GEOSCIENCE LA English DT Article DE Impoundment; Slurry; Refuse; Mining; Coal; Breakthrough ID STATIC LIQUEFACTION; TAILINGS; CONSOLIDATION AB On October 11, 2000, an estimated 306 million gallons of water and fine coal refuse slurry broke through a bedrock barrier from an impoundment in Martin County, eastern Kentucky, into an adjacent underground mine. Approximately 260 million gallons of the water and coal slurry discharged from two underground mine portals and affected over 75 miles of streams in Kentucky and West Virginia. As a result of this and several other breakthroughs over just half a decade, the U.S. Office of Surface Mining Reclamation and Enforcement (OSM) and other institutions undertook investigations to assess the causes of the events, the potential for additional breakthroughs in the future, and available methods for preventing them. In addition to needed improvements in the design, construction, and inspection of the facilities, the studies have addressed issues pertaining to the flow characteristics of refuse slurry, not only in impoundments still receiving pumped slurry, but also in "idle'' and reclaimed facilities. Related questions concern: (1) the effects on breakthrough potential of the impoundment abandonment process and construction of slurry cells on top of capped structures; and (2) appropriate measures and available methods that may be used to ensure that underground mines adjacent to or underlying impoundments are known and accurately located. Current information on the engineering properties of coal refuse in existing facilities provides no assurance against fine refuse flowability during any stage in the impoundment construction and reclamation process or after reclamation has been completed. Due to this uncertainty, thorough site investigations and conservative measures in design, construction, reclamation, and quality control are of paramount importance. C1 [Michael, Peter R.; Stump, Donald E., Jr.] USA, Off Surface Min Reclamat & Enforcement, Pittsburgh, PA 15220 USA. [Richmond, Michael W.] USA, Off Surface Min Reclamat & Enforcement, Charleston, WV 25301 USA. [Superfesky, Michael J.] USA, Off Surface Min Reclamat & Enforcement, Morgantown, WV 26508 USA. [Chavel, Lisa K.] USA, Corps Engineers, Chicago, IL 60606 USA. RP Michael, PR (reprint author), USA, Off Surface Min Reclamat & Enforcement, 3 Pkwy Ctr, Pittsburgh, PA 15220 USA. EM pmichael@osmre.gov NR 43 TC 0 Z9 0 U1 0 U2 2 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1078-7275 J9 ENVIRON ENG GEOSCI JI Environ. Eng. Geosci. PD AUG PY 2010 VL 16 IS 3 BP 299 EP 314 PG 16 WC Engineering, Environmental; Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 649BY UT WOS:000281743000009 ER PT J AU Voinov, A Cerco, C AF Voinov, Alexey Cerco, Carl TI Model integration and the role of data SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE Modularity; Calibration; Integrated modeling; Chesapeake Bay; Module linking; Components AB Model integration is becoming increasingly important as our impacts on the environment become more severe and the systems we analyze become more complex. There are numerous attempts to make different models work in concert. However model integration usually treats models as software components only, ignoring the evolving nature of models and their constant modification and re-calibration to better represent reality. As a result, the changes that used to impact only contained models of subsystems, now propagate throughout the integrated system, across multiple model components. This makes it harder to keep the overall complexity under control and, in a way, defeats the purpose of modularity, where efficiency is supposed to be gained from independent development of modules. We argue that data that are available for module calibration can serve as an intermediate linkage tool, sitting between modules and providing a module-independent baseline, which is then adjusted when scenarios are to be run. In this case, it is not the model output that is directed into the next model. Rather, model output is presented as a variation around the baseline trajectory, and it is this variation that is then fed into the next module down the chain. The Chesapeake Bay Program suite of models is used to illustrate these problems and the possible remedy. Published by Elsevier Ltd. C1 [Cerco, Carl] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. EM aavoinov@gmail.com RI Voinov, Alexey/F-7397-2010; Faculty of ITC, Dep Nat. Resources/C-4295-2014 OI Voinov, Alexey/0000-0002-2985-4574; NR 23 TC 22 Z9 24 U1 0 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 EI 1873-6726 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD AUG PY 2010 VL 25 IS 8 BP 965 EP 969 DI 10.1016/j.envsoft.2010.02.005 PG 5 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA 608SR UT WOS:000278606800008 ER PT J AU Furtado, MD Lumley, LA Robison, C Tong, LC Lichtenstein, S Yourick, DL AF Furtado, Marcio de Araujo Lumley, Lucille A. Robison, Christopher Tong, Lawrence C. Lichtenstein, Spencer Yourick, Debra L. TI Spontaneous recurrent seizures after status epilepticus induced by soman in Sprague-Dawley rats SO EPILEPSIA LA English DT Article DE Organophosphorus; Status epilepticus; EEG; Neuropathology; Spontaneous recurrent seizures ID TEMPORAL-LOBE EPILEPSY; SUSTAINING STATUS EPILEPTICUS; LIMBIC STATUS EPILEPTICUS; KAINATE-INDUCED EPILEPSY; ELECTRICAL-STIMULATION; KAINIC ACID; PILOCARPINE; MECHANISMS; MODEL; EPILEPTOGENESIS AB P>Purpose: Exposure to toxic levels of organophosphorus (OP) nerve agents can lead to seizures, respiratory failure, and, if untreated, death. The cholinesterase inhibitor soman belongs to the class of OP nerve agents and can cause status epilepticus (SE) and brain damage due to neuroexcitotoxicity. In the present study, electroencephalographic seizures are characterized through telemetry implants in rats exposed to soman, followed by treatment with therapeutics similar to those administered after nerve agent exposure. Methods: Cortical electroencephalography (EEG), motor activity and body temperature were recorded continuously for 2 days preexposure and 15 days postexposure to verify the occurrence of spontaneous recurrent seizures (SRS) after soman exposure. Results: Behavioral seizures were monitored and the latency to SE was 7.8 +/- 4.0 min after exposure. Among the rats that showed SE, approximately 90% had prolonged seizures within the initial 3 days after soman exposure. Five percent of the rats developed stage 1 seizures, 16% stage 2, 23% stage 3, 18% stage 4, and 38% stage 5. Seventy-nine percent of the rats presented SE and epileptiform-like discharges several days after SE, and 28.9% of those with SE experienced electrographic SRS. The latency to the appearance of SRS ranged from 5-10 days. Fiber degeneration evaluated through silver staining revealed damage in cortical and subcortical areas directly correlated with SE. Discussion: The presence of SRS after seizures induced by soman highlights the importance of quantifying SRS in studies where the objective is to find new therapeutics against soman-induced seizures. C1 [Yourick, Debra L.] Walter Reed Army Inst Res, Off Sci Director, Div Brain Dysfunct & Blast Injury, Silver Spring, MD 20910 USA. [Lumley, Lucille A.; Robison, Christopher] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Yourick, DL (reprint author), Walter Reed Army Inst Res, Off Sci Director, Div Brain Dysfunct & Blast Injury, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Debra.Yourick@us.army.mil RI Yourick, Debra/A-2121-2011; OI Robison, Christopher/0000-0001-8693-6149 FU Defense Threat Reduction Agency [I.E0042-08-WR-C] FX The Defense Threat Reduction Agency (Grant I.E0042-08-WR-C) has provided financial and programmatic support. The technical assistance of Mike Stone, Benjamin Robertson, Mike Addis, Kristin Clements, Seth Fairfax, Benjamin Litwack, Jamie Waterhouse, Theresa Ward, Joshua Kraft, Sarah Parylak, and Stephen Estes is gratefully acknowledged. NR 49 TC 14 Z9 14 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0013-9580 J9 EPILEPSIA JI Epilepsia PD AUG PY 2010 VL 51 IS 8 BP 1503 EP 1510 DI 10.1111/j.1528-1167.2009.02478.x PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA 635PW UT WOS:000280669600019 ER PT J AU Cheuvront, SN Kenefick, RW Ely, BR Harman, EA Castellani, JW Frykman, PN Nindl, BC Sawka, MN AF Cheuvront, Samuel N. Kenefick, Robert W. Ely, Brett R. Harman, Everett A. Castellani, John W. Frykman, Peter N. Nindl, Bradley C. Sawka, Michael N. TI Hypohydration reduces vertical ground reaction impulse but not jump height SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Dehydration; Fluid balance; Strength-to-mass ratio; Jump performance ID HUMAN SKELETAL-MUSCLE; RAPID WEIGHT-LOSS; EXERCISE PERFORMANCE; POWER; DEHYDRATION; STRENGTH; MEN; REHYDRATION; REDUCTION; RESPONSES AB This study examined vertical jump performance using a force platform and weighted vest to determine why hypohydration (similar to 4% body mass) does not improve jump height. Measures of functional performance from a force platform were determined for 15 healthy and active males when euhydrated (EUH), hypohydrated (HYP) and hypohydrated while wearing a weighted vest (HYP(v)) adjusted to precisely match water mass losses. HYP produced a significant loss of body mass [-3.2 +/- 0.5 kg (-3.8 +/- 0.6%); P < 0.05], but body mass in HYPv was not different from EUH. There were no differences in absolute or relative peak force or power among trials. Jump height was not different between EUH (0.380 +/- 0.048 m) and HYP (0.384 +/- 0.050 m), but was 4% lower (P < 0.05) in HYPv (0.365 +/- 0.52 m) than EUH due to a lower jump velocity between HYPv and EUH only (P < 0.05). However, vertical ground reaction impulse (VGRI) was reduced in both HYP and HYPv (2-3%) compared with EUH (P < 0.05). In conclusion, this study demonstrates the failure to improve jump height when HYP can be explained by offsetting reductions in both VGRI and body mass. C1 [Cheuvront, Samuel N.; Kenefick, Robert W.; Ely, Brett R.; Castellani, John W.; Sawka, Michael N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Harman, Everett A.; Frykman, Peter N.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Samuel.n.cheuvront@us.army.mil NR 46 TC 7 Z9 7 U1 6 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD AUG PY 2010 VL 109 IS 6 BP 1163 EP 1170 DI 10.1007/s00421-010-1458-y PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 629TV UT WOS:000280223500018 PM 20379829 ER PT J AU Hendrickson, NR Sharp, MA Alemany, JA Walker, LA Harman, EA Spiering, BA Hatfield, DL Yamamoto, LM Maresh, CM Kraemer, WJ Nindl, BC AF Hendrickson, Nathan R. Sharp, Marilyn A. Alemany, Joseph A. Walker, Leila A. Harman, Everett A. Spiering, Barry A. Hatfield, Disa L. Yamamoto, Linda M. Maresh, Carl M. Kraemer, William J. Nindl, Bradley C. TI Combined resistance and endurance training improves physical capacity and performance on tactical occupational tasks SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Physical readiness training; Concurrent training; Resistance training; Periodization ID SKELETAL-MUSCLE ADAPTATIONS; CONCURRENT STRENGTH; NEUROMUSCULAR ADAPTATIONS; EXPLOSIVE-STRENGTH; EXERCISE; MEN; COMPATIBILITY; INTERFERENCE; FITNESS; HUMANS AB The purpose of this study is to evaluate the effectiveness of aerobic endurance (E), strength (R), and combined endurance and strength (CB) training for improving performance of tactical occupational tasks and determine if combined training interferes with performance enhancements of E or R alone. A total of 56 recreationally active women were randomly placed into four groups: R (n = 18), E (n = 13), CB (n = 15), Control (n = 10). Subjects trained three non-consecutive days per week for 8 weeks. Performance was measured pre-, mid-, and post-training for bench press one-repetition maximum (1-RM), squat 1-RM, bench press throw and squat jump peak power, VO(2peak), 3.2 km load carriage (LC), 3.2 km run (run), and repetitive lift and carry (RLC). R and E demonstrated improvements which were generally specific to their training. R improved squat (48.3%) and bench press 1-RM (23.8%), bench press throw (41.9%), RLC (31.3%), and LC (11.5%). E improved run (14.7%), VO(2peak) (6.2%), squat 1-RM (15.3%), LC (12.9%), and RLC (22.5%). CB improved squat (37.6%) and bench press 1-RM (20.9%), bench press throw (39.6%), VO(2peak) (7.6%), run (10.4%), LC (13.1%), and RLC (45.5%). Post-training 1-RM squat was greater in R and CB than E, while E completed the 3.2 km load carriage task faster than C. In conclusion, 8 weeks of combined training improved performance in all tactical occupational tasks measured and did not interfere with improvements in strength, power and endurance measures compared to R or E alone. C1 [Hendrickson, Nathan R.; Sharp, Marilyn A.; Alemany, Joseph A.; Walker, Leila A.; Harman, Everett A.; Nindl, Bradley C.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Spiering, Barry A.; Hatfield, Disa L.; Yamamoto, Linda M.; Maresh, Carl M.; Kraemer, William J.] Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA. RP Nindl, BC (reprint author), USA, Mil Performance Div, Environm Med Res Inst, Bldg 42,Kansas St, Natick, MA 01760 USA. EM nathan.hendrickson@us.army.mil FU Medical Research and Material Command Bone Health FX This study was funded, in part, by a grant from the Medical Research and Material Command Bone Health Research Program to BCN. NR 37 TC 29 Z9 29 U1 1 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD AUG PY 2010 VL 109 IS 6 BP 1197 EP 1208 DI 10.1007/s00421-010-1462-2 PG 12 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 629TV UT WOS:000280223500022 PM 20383644 ER PT J AU Yamanaka, T Sumita-Sasazaki, Y Sugimori, C Matsumoto-Mashimo, C Yamane, K Mizukawa, K Yoshida, M Hayashi, H Nambu, T Leung, KP Fukushima, H AF Yamanaka, Takeshi Sumita-Sasazaki, Yoko Sugimori, Chieko Matsumoto-Mashimo, Chiho Yamane, Kazuyoshi Mizukawa, Kenji Yoshida, Masahiro Hayashi, Hiroyuki Nambu, Takayuki Leung, Kai-Poon Fukushima, Hisanori TI Biofilm-like structures and pathogenicity of Escherichia hermannii YS-11, a clinical isolate from a persistent apical periodontitis lesion SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY LA English DT Article DE Escherichia hermannii; biofilm; Wzt; apical periodontitis ID YERSINIA-ENTEROCOLITICA; COLI O157-H7; O-ANTIGEN; PERIAPICAL PATHOSIS; BRUCELLA-MELITENSIS; BETA-LACTAMASE; ROOT CANALS; IDENTIFICATION; RESISTANCE; TEETH AB Escherichia hermannii, formerly classified as enteric group 11 of Escherichia coli, is considered to be nonpathogenic. In this report, we described some of the pathogenic properties of a viscous material-producing E. hermannii strain YS-11, which was clinically isolated from a persistent apical periodontitis lesion. YS-11 possessed cell surface-associated meshwork-like structures that are found in some biofilm-forming bacteria and its viscous materials contained mannose-rich exopolysaccharides. To further examine the biological effect of the extracellular viscous materials and the meshwork structures, we constructed a number of mutants using transposon mutagenesis. Strain 455, which has a transposon inserted into wzt, a gene that encodes an ATP-binding cassette transporter, lacked the expression of the cell surface-associated meshwork structures and the ability to produce extracellular materials. Complementation of the disrupted wzt in strain 455 with an intact wzt resulted in the restoration of these phenotypes. We also compared these strains in terms of their ability to induce abscess formation in mice as an indication of their pathogenicity. Strains with meshwork-like structures induced greater abscesses than those induced by strains that lacked such structures. These results suggest that the ability to produce mannose-rich exopolysaccharides and to form meshwork-like structures on E. hermannii might contribute to its pathogenicity. C1 [Yamanaka, Takeshi; Sumita-Sasazaki, Yoko; Sugimori, Chieko; Matsumoto-Mashimo, Chiho; Yamane, Kazuyoshi; Mizukawa, Kenji; Nambu, Takayuki; Fukushima, Hisanori] Osaka Dent Univ, Dept Bacteriol, Hirakata, Osaka 5731121, Japan. [Yoshida, Masahiro; Hayashi, Hiroyuki] Osaka Dent Univ, Dept Endodont, Hirakata, Osaka 5731121, Japan. [Leung, Kai-Poon] USA, Walter Reed Army Inst Res, Microbiol Branch, Dent & Trauma Res Detachment, Great Lakes, IL USA. RP Yamanaka, T (reprint author), Osaka Dent Univ, Dept Bacteriol, 8-1 Kuzuha Hanazono, Hirakata, Osaka 5731121, Japan. EM yamanaka@cc.osaka-dent.ac.jp RI Usher, Kayley/F-7342-2011 FU Osaka Dental University [A05-09, B08-01] FX We are grateful to Mr Hideaki Hori (the Institute of Dental Research, Osaka Dental University) for his excellent assistance with the electron microscopy. A part of this research was performed at the Institute of Dental Research, Osaka Dental University. This study was supported in part by the Osaka Dental University Research Fund (A05-09) and Osaka Dental University Joint Research Funds (B08-01). NR 39 TC 2 Z9 3 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0928-8244 J9 FEMS IMMUNOL MED MIC JI FEMS Immunol. Med. Microbiol. PD AUG PY 2010 VL 59 IS 3 BP 456 EP 465 DI 10.1111/j.1574-695X.2010.00700.x PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 625MW UT WOS:000279900400024 PM 20553325 ER PT J AU Lu, YH Gribok, AV Ward, WK Reifman, J AF Lu, Yinghui Gribok, Andrei V. Ward, W. Kenneth Reifman, Jaques TI The Importance of Different Frequency Bands in Predicting Subcutaneous Glucose Concentration in Type 1 Diabetic Patients SO IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING LA English DT Article DE Autoregressive prediction models; continuous glucose monitoring (CGM); diabetes; glucose dynamics; glucose signal frequency analysis ID INSULIN-SECRETION; LINEAR PREDICTION; DAWN PHENOMENON; PLASMA-GLUCOSE; MODULATION; MELLITUS; DYNAMICS AB We investigated the relative importance and predictive power of different frequency bands of subcutaneous glucose signals for the short-term (0-50 min) forecasting of glucose concentrations in type 1 diabetic patients with data-driven autoregressive (AR) models. The study data consisted of minute-by-minute glucose signals collected from nine deidentified patients over a five-day period using continuous glucose monitoring devices. AR models were developed using single and pairwise combinations of frequency bands of the glucose signal and compared with a reference model including all bands. The results suggest that: for open-loop applications, there is no need to explicitly represent exogenous inputs, such as meals and insulin intake, in AR models; models based on a single-frequency band, with periods between 60-120 min and 150-500 min, yield good predictive power (error <3 mg/dL) for prediction horizons of up to 25 min; models based on pairs of bands produce predictions that are indistinguishable from those of the reference model as long as the 60-120 min period band is included; and AR models can be developed on signals of short length (similar to 300 min), i.e., ignoring long circadian rhythms, without any detriment in prediction accuracy. Together, these findings provide insights into efficient development of more effective and parsimonious data-driven models for short-term prediction of glucose concentrations in diabetic patients. C1 [Lu, Yinghui; Gribok, Andrei V.; Reifman, Jaques] USA, Bioinformat Cell Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Ward, W. Kenneth] iSense Corp, Wilsonville, OR 97070 USA. [Ward, W. Kenneth] Oregon Hlth & Sci Univ, Wilsonville, OR 97070 USA. RP Reifman, J (reprint author), USA, Bioinformat Cell Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM ylu@bioanalysis.org; agribok@gmail.com; kenward503@msn.com; jaques.reifman@us.army.mil FU U.S. Army Medical Department; Advanced Medical Technology Initiative; Telemedicine and Advanced Technology Research Center of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD; U.S. Air Force; University of Washington, Seattle FX This work was supported in part by the U.S. Army Medical Department, Advanced Medical Technology Initiative, Telemedicine and Advanced Technology Research Center of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, and in part by the U.S. Air Force Diabetes Research Program.; W. Kenneth Ward received the Medical degree from the University of Colorado, Boulder, in 1978. Thereafter, he was awarded a Research Fellowship in diabetes and endocrinology at the University of Washington, Seattle. NR 22 TC 10 Z9 10 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9294 J9 IEEE T BIO-MED ENG JI IEEE Trans. Biomed. Eng. PD AUG PY 2010 VL 57 IS 8 BP 1839 EP 1846 DI 10.1109/TBME.2010.2047504 PG 8 WC Engineering, Biomedical SC Engineering GA 652JK UT WOS:000282000900003 PM 20403780 ER PT J AU Wu, YW Chang, SC AF Wu, Ying-Wah Chang, Shih-Chun TI Coding Schemes for Noiseless and Noisy Asynchronous CDMA Systems SO IEEE TRANSACTIONS ON INFORMATION THEORY LA English DT Article DE BCH code; CDMA; extended cyclic code; multiple-access adder channel (MAAC) ID MULTIPLE-ACCESS CHANNEL; CODES AB Novel coding schemes for noiseless and noisy asynchronous code division multiple access (A-CDMA) systems are presented in this paper. The schemes use Wu-Chang spreading code, block interleaver, and synchronizable channel codes to support A-CDMA communications with random delays. For the noiseless case, each active user generates one of M messages, M = left perpendicular(2(T-D) - 1)/(D + 1)right perpendicular, and a (T - D)-stage MLSR encoder encodes the message into a codeword of length T. Given a maximum random delay of D chips, the receiver can decode messages of all active users without ambiguity. For the noisy case, extended Bose-Caldwell cyclic codes are used to encode messages. The extended cyclic codes provide error correction and delay recovery effectively. By using a BCH code of length n as the cyclic code, the extended code can correct up to tau <= left perpendicularn/4right perpendicular errors and recover a maximum random delay of n - 1 chips. C1 [Wu, Ying-Wah] USA, CERDEC, Ft Monmouth, NJ 07703 USA. [Chang, Shih-Chun] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. RP Wu, YW (reprint author), USA, CERDEC, Ft Monmouth, NJ 07703 USA. EM yingwah.wu@us.army.mil; schang@gmu.edu NR 15 TC 2 Z9 2 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9448 J9 IEEE T INFORM THEORY JI IEEE Trans. Inf. Theory PD AUG PY 2010 VL 57 IS 8 BP 3786 EP 3792 DI 10.1109/TIT.2010.2050919 PG 7 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 652JM UT WOS:000282001700011 ER PT J AU Shkuratov, SI Talantsev, EF Baird, J Altgilbers, LL AF Shkuratov, Sergey I. Talantsev, Evgueni F. Baird, Jason Altgilbers, Larry L. TI Miniature Explosively Driven High-Current Transverse-Shock-Wave Ferromagnetic Generators SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Hard ferromagnets; pulsed power; shock wave ferromagnetic generators (FMGs); shock waves ID ND2FE14B HARD FERROMAGNETICS; MAGNETIC PHASE-TRANSITION; PRIMARY POWER; DEMAGNETIZATION; COMPRESSION; FERRIMAGNETS AB Comprehensive studies of explosively driven ferromagnetic generators (FMGs) have been performed. It has been experimentally established that the initial magnetostatic energy stored in the magnetic element of the FMG (determined by the magnet's maximum energy product (BH)(max) and its volume), not the residual magnetic flux density B(r), is the principal parameter that determines the output energy and the amplitude of the signals produced by the generator. Systematic studies were carried out with miniature high-current FMGs containing Nd(2)Fe(14)B high-energy hard ferromagnetic elements having a wide range of sizes. Utilization of transverse-shock demagnetization of Nd(2)Fe(14)B magnets (shock wave propagates across the magnetization vector M) instead of longitudinal-shock demagnetization dramatically changed the design of the FMGs and reduced the mass of the explosives used by two orders of magnitude in comparison with that used in longitudinal FMGs. Data for the initial magnetic flux and shock-induced magnetic flux change in Nd(2)Fe(14)B magnets are presented. It was shown that FMGs with magnets are presented. It was shown that FMGs witha volume of 25 cm(3) are capable of producing pulsed currents with amplitudes of up to 4.4 kA and rise times of 23 mu s in the seed coil of a magnetic flux compression generator. C1 [Shkuratov, Sergey I.; Baird, Jason] Loki Inc, Rolla, MO 65401 USA. [Talantsev, Evgueni F.] Pulsed Power LLC, Lubbock, TX 79416 USA. [Baird, Jason] Missouri Univ Sci & Technol, Dept Min & Nucl Engn, Rolla, MO 65409 USA. [Altgilbers, Larry L.] USA, Space & Missile Def Command, Army Forces Strateg Command, Huntsville, AL 35807 USA. RP Shkuratov, SI (reprint author), Loki Inc, Rolla, MO 65401 USA. EM shkuratov@lokiconsult.com OI Talantsev, Evgeny/0000-0001-8970-7982 NR 21 TC 5 Z9 5 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD AUG PY 2010 VL 38 IS 8 BP 1784 EP 1793 DI 10.1109/TPS.2010.2050498 PN 1 PG 10 WC Physics, Fluids & Plasmas SC Physics GA 664LI UT WOS:000282961100014 ER PT J AU Shkuratov, SI Baird, J Antipov, VG Talantsev, EF Lynch, CS Altgilbers, LL AF Shkuratov, Sergey I. Baird, Jason Antipov, Vladimir G. Talantsev, Evgueni F. Lynch, Christopher S. Altgilbers, Larry L. TI PZT 52/48 Depolarization: Quasi-Static Thermal Heating Versus Longitudinal Explosive Shock SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Depolarization; ferroelectric ceramics; lead zirconate titanate oxides; shock wave effects ID WAVE DEPOLARIZATION; ELECTRICAL RESPONSE; COMPRESSION; POWER; FERROELECTRICS; CERAMICS AB Systematic studies of the depolarization of Pb(Zr(0.52) Ti(0.48))O(3) (PZT 52/48) poled piezoelectric ceramic samples were performed using thermal heating and explosive longitudinal-shock compression. The electric charge density that is released due to thermal heating at a rate of 0.9 K/min was consistent for all sample sizes (Q = 27.8 mu C/cm(2)). The charge density that is released due to shock compression was practically equal to that released due to thermal heating. The PZT 52/48 samples were completely depolarized by longitudinal shock waves at shock front pressures of P(SW) = 1.5 +/- 0.2 GPa. The electric charge that the samples release can be transformed into pulsed power. Miniature explosive-driven ferroelectric generators containing PZT 52/48 ceramic elements with a volume of 0.35-3.5 cm(3) are capable of converting the depolarization charge into pulses of high voltage with amplitudes of up to 22 kV and high power with a peak power of up to 0.35 MW within a time interval of 0.3-1.5 mu s. C1 [Shkuratov, Sergey I.; Baird, Jason; Antipov, Vladimir G.] Loki Inc, Rolla, MO 65401 USA. [Baird, Jason] Missouri Univ Sci & Technol, Dept Min & Nucl Engn, Rolla, MO 65409 USA. [Talantsev, Evgueni F.] Pulsed Power LLC, Lubbock, TX 79416 USA. [Lynch, Christopher S.] Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA 90095 USA. [Altgilbers, Larry L.] USA, Space & Missile Def Command, Huntsville, AL 35807 USA. RP Shkuratov, SI (reprint author), Loki Inc, Rolla, MO 65401 USA. EM shkuratov@lokiconsult.com; jbaird@lokiconsult.com; vantipov@yahoo.com; E.Talantsev@irl.cri.nz; clynch@lokiconsult.com; larry.altgilbers@smdc.army.mil RI Lynch, Christopher/A-9886-2013; OI Lynch, Christopher/0000-0001-9989-7097; Talantsev, Evgeny/0000-0001-8970-7982 NR 27 TC 8 Z9 8 U1 0 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD AUG PY 2010 VL 38 IS 8 BP 1856 EP 1863 DI 10.1109/TPS.2010.2050497 PN 1 PG 8 WC Physics, Fluids & Plasmas SC Physics GA 664LI UT WOS:000282961100024 ER PT J AU Kosinski, JA Pastore, RA Yang, JS Yang, XM Turner, JA AF Kosinski, John A. Pastore, Robert A., Jr. Yang, Jiashi Yang, Xiaomeng Turner, Joseph A. TI Stress-Induced Frequency Shifts of Degenerate Thickness-Shear Modes in Rotated Y-Cut Quartz Resonators SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID ELECTROELASTIC EQUATIONS; FIELDS; BIAS AB We study stress-induced frequency shifts in a rotated Y-cut quartz resonator (theta = 23.7 degrees) with degenerate fundamental thickness-shear modes when the biasing stress is not present. Using the recently derived perturbation procedure for degenerate frequencies in crystal resonators, we show that when a planar stress system is applied, the degenerate frequency splits into two. This phenomenon is expected to be typical for degenerate frequencies in crystal resonators and may be responsible in part for the jump discontinuities in frequency temperature curves and other frequency jump phenomena. C1 [Kosinski, John A.; Pastore, Robert A., Jr.] USA, CECOM, Ft Monmouth, NJ USA. [Yang, Jiashi; Yang, Xiaomeng; Turner, Joseph A.] Univ Nebraska, Dept Engn Mech, Lincoln, NE USA. RP Kosinski, JA (reprint author), USA, CECOM, Ft Monmouth, NJ USA. EM jyang1@unl.edu RI Turner, Joseph/F-5165-2010 FU Army Research Office [DAAD19-01-1-0443] FX This work was supported by the Army Research Office under DAAD19-01-1-0443. NR 16 TC 2 Z9 2 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD AUG PY 2010 VL 57 IS 8 BP 1880 EP 1883 DI 10.1109/TUFFC.2010.1628 PG 4 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 702DJ UT WOS:000285874500020 PM 20679018 ER PT J AU Kissner, TL Cisney, ED Ulrich, RG Fernandez, S Saikh, KU AF Kissner, Teri L. Cisney, Emily D. Ulrich, Robert G. Fernandez, Stefan Saikh, Kamal U. TI Staphylococcal enterotoxin A induction of pro-inflammatory cytokines and lethality in mice is primarily dependent on MyD88 SO IMMUNOLOGY LA English DT Article DE cytokine; d-galactosamine; knockout; lipopolysaccharides; myeloid differentiation primary-response protein 88; staphylococcal enterotoxin A ID TUMOR-NECROSIS-FACTOR; TOXIC-SHOCK-SYNDROME; RECEPTOR SIGNAL-TRANSDUCTION; INTENSIVE-CARE UNITS; FACTOR-KAPPA-B; CLASS-II; HUMAN-MONOCYTES; HLA-DR; MYD88-DEFICIENT MICE; TYROSINE KINASE AB P>Staphylococcal enterotoxin (SE) -induced toxic shock is triggered by inflammatory cytokine signal amplification after SE binding to major histocompatibility complex class II molecules on antigen-presenting cells and T-cell receptors. Identifying host cellular elements contributing to this pro-inflammatory signal amplification is critical for developing a strategy for therapeutic intervention. Myeloid differentiation primary-response protein 88 (MyD88) is an intracellular signalling adaptor protein primarily known for mediating pro-inflammatory cytokine responses. We investigated the role of MyD88 in staphylococcal enterotoxin A (SEA) -treated cell cultures and mouse models of toxic shock. Our results demonstrated that elevated levels of tumour necrosis factor-alpha, interferon-gamma, interleukin-1 alpha/beta (IL-1 alpha/beta), IL-2 and IL-6 production correlated with up-regulation of MyD88 after treatment of spleen cells and mice with SEA alone or in combination with lipopolysaccharide (LPS). The SEA-induced lethality was also observed in (LPS-independent) d-galactosamine-sensitized mice. While LPS potentiated SEA-induced cytokine responses, d-galactosamine treatment had no additive effect. Most importantly, our results demonstrated that MyD88-/- mice were resistant to SEA-induced toxic shock and had reduced pro-inflammatory cytokine responses. These results suggest that SEA-induced lethality is primarily dependent on MyD88. Our findings offer an important insight on potential therapeutic treatment of SEA-induced toxic shock targeting MyD88. C1 [Kissner, Teri L.; Cisney, Emily D.; Ulrich, Robert G.; Fernandez, Stefan; Saikh, Kamal U.] USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD 21702 USA. RP Saikh, KU (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD 21702 USA. EM kamal.saikh@amedd.army.mil FU Defense Threat Reduction Agency FX This work was funded by the Defense Threat Reduction Agency to K. U. S. The authors thank Amy Egnew for technical assistance, Diana Fisher for statistical analysis, Lorraine Farinick for figure preparation, and Dr Bradley Stiles for critical review of the manuscript. NR 39 TC 13 Z9 13 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0019-2805 J9 IMMUNOLOGY JI Immunology PD AUG PY 2010 VL 130 IS 4 BP 516 EP 526 DI 10.1111/j.1365-2567.2010.03249.x PG 11 WC Immunology SC Immunology GA 623JM UT WOS:000279735800007 PM 20465563 ER PT J AU Chia, VM Li, Y Quraishi, SM Graubard, BI Figueroa, JD Weber, JP Chanock, SJ Rubertone, MV Erickson, RL McGlynn, KA AF Chia, V. M. Li, Y. Quraishi, S. M. Graubard, B. I. Figueroa, J. D. Weber, J-P. Chanock, S. J. Rubertone, M. V. Erickson, R. L. McGlynn, K. A. TI Effect modification of endocrine disruptors and testicular germ cell tumour risk by hormone-metabolizing genes SO INTERNATIONAL JOURNAL OF ANDROLOGY LA English DT Article DE hormone-metabolizing genes; persistent organochlorine pesticides; polychlorinated biphenyls; testicular germ cell tumours ID BREAST-CANCER RISK; CHLORINATED-HYDROCARBON LEVELS; POLYCHLORINATED-BIPHENYLS; CYTOCHROME-P450 1A1; HUMAN-SERUM; POLYMORPHISMS; HEXACHLOROBENZENE; HEALTH; TRENDS; BLOOD AB P>It has been hypothesized that the increased prevalence of testicular germ cell tumours (TGCT) may be attributable to endocrine disrupting chemicals, such as persistent organic pollutants (POPs); these may be modulated by hormone-metabolizing enzymes. Using data from 568 cases and 698 controls enrolled in the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study, we examined associations between TGCT and POPs, including p,p'-dichlorodiphenyldichloroethylene, chlordane-related compounds and polychlorinated biphenyls (PCBs), modified by polymorphisms in five hormone-metabolizing genes (CYP17A1, CYP1A1, HSD17B1, HSD17B4 and AR). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models that stratified associations of POP exposure and TGCT risk by genotype. Two polymorphisms in CYP1A1, rs1456432 and rs7495708, modified the association between trans-nonachlor and total chlordanes and TGCT risk. Among men with a minor allele for rs1456432, those with the highest quartiles had an increased risk of TGCT (OR = 1.90, 95% CI, 1.01-3.56) compared with those with the lowest; there was no increased risk among men with the homozygous major allele genotype (p-interactions = 0.024). Similar results were seen for rs7495708. HSD17B4 rs384346 modified the associations between TGCT risk and PCB-118 and PCB-138 concentrations: the 45-55% reductions in TGCT risk for men with the highest quartiles compared with the lowest quartiles were only present in those who had a major homozygous allele genotype (p-interactions < 0.04). Thus, there are suggestions that certain CYP1A1 and HSD17B4 polymorphisms may modify the associations between POPs and TGCT risk. With false discovery rate values > 0.2, however, caution is advisable when interpreting the findings of this study. C1 [McGlynn, K. A.] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA. [Weber, J-P.] Inst Natl Sante Publ Quebec, Toxicol Ctr, Quebec City, PQ, Canada. [Rubertone, M. V.] USA, Ctr Hlth Promot & Prevent Med, Washington, DC 20310 USA. [Erickson, R. L.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP McGlynn, KA (reprint author), NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, EPS Suite 550,6120 Execut Blvd, Rockville, MD 20892 USA. EM mcglynnk@mail.nih.gov FU NIH, National Cancer Institute FX This work was supported by the Intramural Research Program of the NIH, National Cancer Institute. NR 29 TC 19 Z9 19 U1 1 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0105-6263 J9 INT J ANDROL JI Int. J. Androl. PD AUG PY 2010 VL 33 IS 4 BP 588 EP 596 DI 10.1111/j.1365-2605.2009.00975.x PG 9 WC Andrology SC Endocrinology & Metabolism GA 622MZ UT WOS:000279669200004 PM 19627379 ER PT J AU Bartley, RH Bartley, SE Springer, DJ Erwin, DM AF Bartley, Russell H. Bartley, Sylvia E. Springer, David J. Erwin, Diane M. TI New observations on the Middle Fork Eel River coal-bearing beds, Mendocino County, California, USA SO INTERNATIONAL JOURNAL OF COAL GEOLOGY LA English DT Article DE Neogene; California Coast Ranges; Coal; Paleoenvironment; Fossil mollusks; Palynology ID NORTHERN CALIFORNIA; TRIPLE JUNCTION; LATE NEOGENE; TECTONICS; RANGES; OLIGOCENE; SEQUENCE; MIOCENE; CLIMATE; FAULT AB Mid-19th century reports of "immense" coal outcrops in the Middle Fork Eel River (MFER) drainage near Round Valley in California's northern Coast Ranges fueled the early geological interest in this area, with mine development the primary focus of many studies. It was not until Samuel G. Clark's 1940 "Geology of the Covelo District, Mendocino County,California," that the coal was placed in its regional geologic context and assigned to the Miocene, a determination that relied primarily on a Desmostylus hesperus molar found in shale overlying the coal and an associated equivocal, though Miocene-compatible, marine molluscan fauna. Our investigation of the MFER coal-bearing beds has provided new data from foraminifera, marine mollusks, fish remains, and the first reported fossil plants, which as a whole support Clark's Miocene age assignment. We also present an updated stratigraphy proposing under modern-day stratigraphic protocols that the informal name Sand Bank beds (SBb) be used in place of the Temblor Formation to refer to the SBb coal-bearing fluvial-marine unit. Analysis of the SBb stratigraphy and sedimentology reveals the presence of a fluvial system that flowed from a distal upland region southward toward the paleocoast of California. An abundant diverse palynoflora containing lycophytes, ferns, conifers, and mesic, thermophillic herbaceous and woody angiosperms indicates the drainage flowed through a coastal swampy forested bottomland and estuarine environment before emptying into a coastal basin. Presence of Taxodium-like wood, foliage, pollen, and other "hydrophiles" suggests the MFER coal was a local mire buried by the progradation of the SBb fluvial system during a regressive phase, an interpretation to be tested with future field work and detailed compositional analysis of the coal. (C) 2010 Elsevier B.V. All rights reserved. C1 [Erwin, Diane M.] Univ Calif Berkeley, Museum Paleontol, Berkeley, CA 94720 USA. [Bartley, Russell H.] Mendocino Cty Museum, Willits, CA 95490 USA. [Springer, David J.] Coll Redwoods Mendocino Coast, Ft Bragg, CA 95437 USA. RP Erwin, DM (reprint author), Univ Calif Berkeley, Museum Paleontol, 1101 Valley Life Sci Bldg, Berkeley, CA 94720 USA. EM nhh@mcn.org; nhh@mcn.org; fbgeodude@yahoo.com; dmerwin@berkeley.edu FU Annie Montague Alexander Endowment FX We thank local Round Valley landowners for access to sites described in the present study, especially the Robert "Bobby" Fetzer family, Craig M. Christensen, and former Diamond H Ranch manager Peter Newton. We also thank the following people: Charles L Powell for assistance with marine molluscan identifications and discussions regarding the Temblor Formation; Carol Hotton and Tad Dillhoff for palynology discussions; David R. Lindberg, Kenneth Finger and Mark Goodwin for their insights and practical assistance; Margaret Gennaro for access to the University of California, Berkeley, S. G. Clark collections; Jean DeMouthe, for access to Fisher's MFER Desmostylus molar; Dale Stickney and Pam Ryan, Wilbur H. Grant Collection at the California Geological Library in Sacramento; Donald A. Coates (Bodega Bay, CA) for discussions on coal fire geology; and Jackie and Harold "Skip" Wollenberg (Fort Bragg, CA) for logistical support and thoughtful reading of the manuscript. D. M. Erwin gratefully acknowledges the Annie Montague Alexander Endowment to the University of California Museum of Paleontology for partial financial support. This is UCMP Contribution No. 2005. NR 62 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-5162 EI 1872-7840 J9 INT J COAL GEOL JI Int. J. Coal Geol. PD AUG 1 PY 2010 VL 83 IS 2-3 SI SI BP 204 EP 228 DI 10.1016/j.coal.2010.01.001 PG 25 WC Energy & Fuels; Geosciences, Multidisciplinary SC Energy & Fuels; Geology GA 644BM UT WOS:000281345400012 ER PT J AU Stany, MP Sunde, J Bidus, MA Rose, GS Elkas, JC AF Stany, Michael P. Sunde, Jan Bidus, Michael A. Rose, G. Scott Elkas, John C. TI The Use of Acellular Dermal Allograft for Vulvovaginal Reconstruction SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE Neovagina; Acellular dermal allograft; Exenteration AB Background: Many different techniques that require the surgeon to harvest autologous tissue to create a neovagina have been described in the literature. Technique: We describe a technique for creating a neovagina with the use of an acellular dermal allograft as a replacement for split-thickness skin graft. Three patients are presented who had a successful creation of a neovagina with this technique. The indications for vaginoplasty include vaginal agglutination from lichen planus, squamous cell carcinoma of the vagina, and vaginal agenesis. Conclusion: The creation of a neovagina using an acellular dermal allograft can be successfully accomplished in patients undergoing constructive and exenterative procedures. The use of an acellular dermal allograft decreases operative time and decreases the incidence of postoperative morbidity because harvesting autologous tissue for the neovagina is not required. C1 [Stany, Michael P.; Rose, G. Scott] Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Sunde, Jan] Madigan Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Tacoma, WA 98431 USA. [Bidus, Michael A.] Portsmouth Naval Hosp, Div Gynecol Oncol, Dept Obstet & Gynecol, Portsmouth, VA USA. [Elkas, John C.] PC, No Virginia Pelv Surg Associates, Fairfax, VA USA. RP Stany, MP (reprint author), Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM michael.stany@amedd.army.mil NR 5 TC 2 Z9 8 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1048-891X J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD AUG PY 2010 VL 20 IS 6 BP 1079 EP 1081 DI 10.1111/IGC.0b013e3181e2ed24 PG 3 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 634HR UT WOS:000280572000027 PM 20683421 ER PT J AU Pasiakos, SM McClung, HL McClung, JP Urso, ML Pikosky, MA Cloutier, GJ Fielding, RA Young, AJ AF Pasiakos, Stefan M. McClung, Holly L. McClung, James P. Urso, Maria L. Pikosky, Matthew A. Cloutier, Gregory J. Fielding, Roger A. Young, Andrew J. TI Molecular Responses to Moderate Endurance Exercise in Skeletal Muscle SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE protein synthesis; protein breakdown; muscle protein turnover; translation initiation; intracellular signaling ID GLYCOGEN-SYNTHASE KINASE-3; PROTEIN-SYNTHESIS; RESISTANCE EXERCISE; TIME-COURSE; PATHWAY; PHOSPHORYLATION; EXPRESSION; RECOVERY; INSULIN; METABOLISM AB This study examined alterations in skeletal-muscle growth and atrophy-related molecular events after a single bout of moderate-intensity endurance exercise. Muscle biopsies were obtained from 10 men (23 +/- 1 yr, body mass 80 +/- 2 kg, and VO(2peak) 45 +/- 1 ml . kg(-1) . min(-1)) immediately (0 hr) and 3 hr after a 60-min bout of cycle exercise (60% +/- 5% VO(2peak)). Corresponding muscle biopsies were also obtained under resting conditions. The phosphorylation status of insulin/IGF-PI3K molecular-signaling proteins, ubiquitin-proteasome-related gene expression, FOXO transcription factors, and myogenic regulatory factors in muscle samples was analyzed using multiplex analysis, Western blotting, and quantitative real-time polymerase chain reaction (qRT-PCR). A condition-time interaction was observed for Akt phosphorylation (p < .05) with multiplexing. Regardless of endurance exercise, Akt phosphorylation decreased and ERK phosphorylation increased at 3 hr compared with 0 hr (p < .05). Levels of p70(S6K) phosphorylation were 110% greater (p < .05) at 3 hr than at 0 hr using Western blots. MuRF mRNA expression postexercise increased; levels were 4.7- and 5.7-fold greater (p < .05) at 0 hr and 3 hr, respectively, than at rest with qRT-PCR. Atrogin mRNA expression was up-regulated 3.2-fold 3 hr postexercise compared with rest. These findings demonstrate modest changes in the molecular responses to moderate endurance exercise in the absence of nutrition. This study provides the groundwork for future investigations designed to optimize the metabolic conditions necessary to positively influence the cellular mechanisms specific to skeletal-muscle protein turnover during recovery from endurance exercise. C1 [Pasiakos, Stefan M.; McClung, Holly L.; McClung, James P.; Pikosky, Matthew A.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Urso, Maria L.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Cloutier, Gregory J.; Fielding, Roger A.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. RP Pasiakos, SM (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RI McClung, James/A-1989-2009; Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU U S. Department of Agriculture, Agricultural Research Service [58-1950-7-707] FX This material is based on work supported by the U S. Department of Agriculture, Agricultural Research Service, under agreement No. 58-1950-7-707. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the U. S. Dept of Agriculture. NR 36 TC 19 Z9 20 U1 1 U2 6 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD AUG PY 2010 VL 20 IS 4 BP 282 EP 290 PG 9 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 640BT UT WOS:000281023000002 PM 20739716 ER PT J AU Sedlock, DA Lee, MG Flynn, MG Park, KS Kamimori, GH AF Sedlock, Darlene A. Lee, Man-Gyoon Flynn, Michael G. Park, Kyung-Shin Kamimori, Gary H. TI Excess Postexercise Oxygen Consumption After Aerobic Exercise Training SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE EPOC; endurance exercise; hormones; rectal temperature; blood lactate ID UPPER-BODY EXERCISE; ENERGY-EXPENDITURE; RESISTANCE EXERCISE; UNTRAINED WOMEN; YOUNG-WOMEN; O2 UPTAKE; INTENSITY; DURATION; RECOVERY; EPOC AB Literature examining the effects of aerobic exercise training on excess postexercise oxygen consumption (EPOC) is sparse. In this study, 9 male participants (19-32 yr) trained (EX) for 12 wk, and 10 in a control group (CON) maintained normal activity. VO(2max), rectal temperature (T(re)), epinephrine, norepinephrine, free fatty acids (FFA), insulin, glucose, blood lactate (BLA), and EPOC were measured before (PRE) and after (POST) the intervention. EPOC at PRE was measured for 120 min after 30 min of treadmill running at 70% VO(2max). EX completed 2 EPOC trials at POST, i.e., at the same absolute (ABS) and relative (REL) intensity; 1 EPOC test for CON served as both the ABS and REL trial because no significant change in VO(2max) was noted. During the ABS trial, total EPOC decreased significantly (p < .01) from PRE (39.4 +/- 3.6 kcal) to POST (31.7 +/- 2.2 kcal). T(re), epinephrine, insulin, glucose, and BLA at end-exercise or during recovery were significantly lower and FFA significantly higher after training. Training did not significantly affect EPOC during the REL trial; however, epinephrine was significantly lower, and norepinephrine and FFA, significantly higher, at end-exercise after training. Results indicate that EPOC varies as a function of relative rather than absolute metabolic stress and that training improves the efficiency of metabolic regulation during recovery from exercise. Mechanisms for the decreased magnitude of EPOC in the ABS trial include decreases in BLA, T(re), and perhaps epinephrine-mediated hepatic glucose production and insulin-mediated glucose uptake. C1 [Sedlock, Darlene A.] Purdue Univ, Wastl Human Performance Lab, W Lafayette, IN 47907 USA. [Lee, Man-Gyoon] Kyung Hee Univ, Grad Sch Phys Educ, Suwon, South Korea. [Flynn, Michael G.] Coll Charleston, Dept Hlth & Human Performance, Charleston, SC 29401 USA. [Park, Kyung-Shin] Texas A&M Int Univ, Fitness & Sports Program, Laredo, TX USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. RP Sedlock, DA (reprint author), Purdue Univ, Wastl Human Performance Lab, W Lafayette, IN 47907 USA. NR 41 TC 9 Z9 9 U1 1 U2 19 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD AUG PY 2010 VL 20 IS 4 BP 336 EP 349 PG 14 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 640BT UT WOS:000281023000008 PM 20739722 ER PT J AU Crum-Cianflone, NF Ren, QA Eberly, LE Ganesan, A Weintrob, A Marconi, V Barthel, RV Agan, BK AF Crum-Cianflone, Nancy F. Ren, Qian Eberly, Lynn E. Ganesan, Anuradha Weintrob, Amy Marconi, Vincent Barthel, Robert V. Agan, Brian K. TI Are HIV-Positive Persons Progressing Faster After Diagnosis Over the Epidemic? SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Letter ID SEROCONVERSION C1 [Crum-Cianflone, Nancy F.; Eberly, Lynn E.; Ganesan, Anuradha; Weintrob, Amy; Marconi, Vincent; Barthel, Robert V.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Infect Dis Clin, San Diego, CA 92152 USA. [Ren, Qian; Eberly, Lynn E.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Marconi, Vincent] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA. [Barthel, Robert V.] USN, Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA. RP Crum-Cianflone, NF (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669; Eberly, Lynn/0000-0003-4763-330X FU NIAID NIH HHS [Y1-AI-5072, HU0001-05-2-0011, Y01 AI005072]; PHS HHS [HU0001-05-2-0011] NR 5 TC 6 Z9 6 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD AUG 1 PY 2010 VL 54 IS 4 BP E6 EP E7 DI 10.1097/QAI.0b013e3181e2d6c1 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 627BR UT WOS:000280013600020 PM 20611033 ER PT J AU Jung, H Pinsukanjana, P Dutta, M Choi, KK Tidrow, MZ AF Jung, Hyeson Pinsukanjana, Paul Dutta, Mitra Choi, Kwong-Kit Tidrow, Meimei Z. TI Structural and optical characterization of infrared hot electron transistor SO JOURNAL OF APPLIED PHYSICS LA English DT Article DE enhanced magnetoresistance; ferromagnetic materials; spin valves; strain sensors ID LOW-TEMPERATURE; PRODUCTION MBE; PHOTODETECTORS; ALXGA1-XAS; GAAS AB We present structural, optical, and transport characterization of long wave infrared hot electron transistor (IHET) based on doped quantum wells of InGaAs/AlGaAs. The atomic resolution images and x-ray diffraction patterns verified a lattice matched and band-gap engineered device structure of IHET. Measured values of the photocurrent were less than the theoretically expected values and indicated a loss of photocurrent between the base of the IHET and the collector. A higher filter height due to high unexpected dopant in the filter barrier was suggested as a possible cause of the current loss. Photoluminescence data in the near infrared showed the existence of such a dopant. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3457122] C1 [Jung, Hyeson; Dutta, Mitra] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. [Pinsukanjana, Paul] Intelligent Epitaxy Technol Inc, Richardson, TX 75081 USA. [Dutta, Mitra] Univ Illinois, Dept Phys, Chicago, IL 60607 USA. [Choi, Kwong-Kit] USA, Res Lab, Adelphi, MD 20783 USA. [Tidrow, Meimei Z.] USA Communic Elect Command, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Jung, H (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. RI Choi, Kwong-Kit/K-9205-2013 FU MDA-STTR [W9113M-08-C-0012] FX Authors thank Professor P. T. Snee in the Department of Chemistry at the University of Illinois at Chicago for the IR fluorescence measurement and discussions. This work was supported by the MDA-STTR under Contract No. W9113M-08-C-0012. NR 14 TC 0 Z9 0 U1 0 U2 6 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 2010 VL 108 IS 3 AR 034515 DI 10.1063/1.3457122 PG 6 WC Physics, Applied SC Physics GA 638ZQ UT WOS:000280941000132 ER PT J AU Nersisyan, S Tabiryan, N Steeves, DM Kimball, BR AF Nersisyan, Sarik Tabiryan, Nelson Steeves, Diane M. Kimball, Brian R. TI Axial polarizers based on dichroic liquid crystals SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID POLARIZATION-CONVERTING DEVICE; SPIRAL PHASE PLATE; SYMMETRIC POLARIZATION; OPTICAL VORTICES; LASER-BEAMS; LIGHT; GENERATION; GRATINGS; CELL AB Polarizers capable of producing linearly polarized beams with axial (radial and azimuthal) symmetry have been fabricated with the aid of a dichroic liquid crystal. Photoalignment was achieved using a printing technique to reduce the UV exposure time required for production of axially aligning substrates from 1 h, typical for direct writing techniques, to 10 min. The polarizing features of axial polarizers and their pairs are characterized and their differences outlined. We demonstrate that the transmission switching contrast of an axial polarizer/analyzer pair, comprised of an electrically controlled liquid crystal cell, is comparable to conventional systems with linear polarizers. The opportunities for using axial polarizers for polarization imaging, sensor protection, and nonlinear optics are discussed. Particularly, we show that the technology could reduce the fluence of a laser beam on an optical sensor without affecting imaging. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3460810] C1 [Nersisyan, Sarik; Tabiryan, Nelson] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. [Steeves, Diane M.; Kimball, Brian R.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Nersisyan, S (reprint author), Beam Engn Adv Measurements Co, 809 S Orlando Ave Suite 1, Winter Pk, FL 32789 USA. EM brian.r.kimball@us.army.mil NR 34 TC 5 Z9 5 U1 2 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 2010 VL 108 IS 3 AR 033101 DI 10.1063/1.3460810 PG 5 WC Physics, Applied SC Physics GA 638ZQ UT WOS:000280941000001 ER PT J AU Panchal, RG Kota, KP Spurgers, KB Ruthel, G Tran, JP Boltz, RC Bavari, S AF Panchal, Rekha G. Kota, Krishna P. Spurgers, Kevin B. Ruthel, Gordon Tran, Julie P. Boltz, Robert C. Dutch Bavari, Sina TI Development of High-Content Imaging Assays for Lethal Viral Pathogens SO JOURNAL OF BIOMOLECULAR SCREENING LA English DT Article DE filoviruses; imaging; Ebola; Marburg; high content ID THROUGHPUT SCREENING ASSAYS; HEMORRHAGIC-FEVER VIRUS; EBOLA-VIRUS; STRUCTURAL INTEGRITY; MARBURG VIRUSES; IDENTIFICATION; REPLICATION; INFECTIONS; INHIBITORS; MONKEYS AB Filoviruses such as Ebola (EBOV) and Marburg (MARV) are single-stranded negative sense RNA viruses that cause acute hemorrhagic fever with high mortality rates. Currently, there are no licensed vaccines or therapeutics to counter filovirus infections in humans. The development of higher throughput/high-content primary screening assays followed by validation using the low-throughput traditional plaque or real-time PCR assays will greatly aid efforts toward the discovery of novel antiviral therapeutics. Specifically, high-content imaging technology is increasingly being applied for primary drug screening. In this study, the authors describe the challenges encountered when optimizing bioassays based on image acquisition and analyses for the highly pathogenic filoviruses Ebola and Marburg. A number of biological and imaging-related variables such as plating density, multiplicity of infection, the number of fields scanned per well, fluorescence intensity, and the cell number analyzed were evaluated during the development of these assays. Furthermore, the authors demonstrate the benefits related to the statistical analyses of single-cell data to account for heterogeneity in the subcellular localization and whole-cell integrated intensity of the viral antigen staining pattern. In conclusion, they show that image-based methods represent powerful screening tools for identifying antiviral compounds for highly pathogenic viruses. (Journal of Biomolecular Screening 2010:755-765) C1 [Panchal, Rekha G.; Spurgers, Kevin B.; Ruthel, Gordon; Tran, Julie P.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Kota, Krishna P.; Boltz, Robert C. Dutch] PerkinElmer, Waltham, MA USA. RP Panchal, RG (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM rekha.panchal@amedd.army.mil FU Defense Threat Reduction Agency FX We thank Lindsay Longobardi for technical support and Diana Fisher for statistical analysis of the data. This project was funded by the Defense Threat Reduction Agency (to RGP and SB). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army. NR 24 TC 29 Z9 30 U1 0 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1087-0571 J9 J BIOMOL SCREEN JI J. Biomol. Screen PD AUG PY 2010 VL 15 IS 7 BP 755 EP 765 DI 10.1177/1087057110374357 PG 11 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Chemistry GA 675BP UT WOS:000283799100006 PM 20639507 ER PT J AU Bower, KS Edwards, JD Ryan, DS Coe, CD Hope, RJ Sliney, DH AF Bower, Kraig S. Edwards, Jayson D. Ryan, Denise Sediq Coe, Charles D. Hope, Robert J. Sliney, David H. TI Scattered ultraviolet emissions during refractive surgery using a high-frequency, wavefront-optimized excimer laser platform SO JOURNAL OF CATARACT AND REFRACTIVE SURGERY LA English DT Article ID CORNEAL EPITHELIAL REMOVAL; OPTICAL RADIATION; PHOTOREFRACTIVE KERATECTOMY; IRRADIATION; GUIDELINES; EXPOSURE AB PURPOSE: To evaluate occupational ultraviolet (UV) exposure during photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) with the Allegretto Wave Eye-Q 400 Hz excimer laser. SETTING: Walter Reed Center for Refractive Surgery, Washington, DC, USA. METHODS: Intraoperative UV measurements were performed during PRK with epithelial removal using an Amoils brush, PRK with epithelial removal using 20% ethanol, or femtosecond LASIK. A Laser Star power/energy meter with a silicone detector (model PD-10) was used for the measurements. The maximum pulse energy 25.4 cm from the corneal surface was recorded for each surgical procedure. Measurements were evaluated using a worst-case scenario for exposure of operating room personnel, and the results were compared with the occupational exposure limit set by the International Commission on Non-Ionizing Radiation Protection. RESULTS: Measurements were taken during 15 cases of each procedure. The mean maximum exposure was 129.38 nJ/pulse +/- 79.48 (SD) during brush PRK, 69.72 +/- 68.80 nJ/pulse during ethanol PRK, and 29.17 +/- 13.82 nJ/pulse during LASIK. The mean maximum exposure per eye was 0.085 mJ/cm(2), 0.046 mJ/cm(2), and 0.01 mJ/cm(2), respectively. The worst-case cumulative exposure during a heavy workday of 20 patients (40 eyes) was calculated at 3.92 mJ/cm(2), 1.51 mJ/cm(2), and 0.79 mJ/cm(2) for brush PRK, ethanol PRK, and LASIK, respectively. CONCLUSION: Results indicate that the excimer laser platform used in the study may yield greater UV exposure than previous systems; however, the levels did not exceed occupational exposure limits. C1 [Bower, Kraig S.] Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Washington, DC 20307 USA. [Edwards, Jayson D.] Univ Florida, Coll Med, Dept Ophthalmol, Jacksonville, FL USA. RP Bower, KS (reprint author), Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Room 2F-205,6900 Georgia Ave NW, Washington, DC 20307 USA. EM kraig.bower@amedd.army.mil NR 11 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0886-3350 J9 J CATARACT REFR SURG JI J. Cataract. Refract. Surg. PD AUG PY 2010 VL 36 IS 8 BP 1344 EP 1348 DI 10.1016/j.jcrs.2010.02.013 PG 5 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 640KJ UT WOS:000281049800015 PM 20656158 ER PT J AU Lee, MS Olson, MA AF Lee, Michael S. Olson, Mark A. TI Protein Folding Simulations Combining Self-Guided Langevin Dynamics and Temperature-Based Replica Exchange SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID IMPLICIT SOLVENT MODELS; FREE-ENERGY LANDSCAPE; TRP-CAGE MINIPROTEIN; MOLECULAR-DYNAMICS; EXPLICIT-SOLVENT; GENERALIZED BORN; FORCE-FIELDS; MINI PROTEIN; WATER; BIOMOLECULES AB Computer simulations are increasingly being used to predict thermodynamic observables for folding small proteins Key to continued progress in this area is the development of algorithms that accelerate conformational sampling Temperature-based replica exchange (ReX) is a commonly used protocol whereby simulations at several temperatures are simultaneously performed and temperatures are exchanged between simulations via a Metropolis criterion Another method, self-guided Langevin dynamics (SGLD), expedites conformational sampling by accelerating low-frequency, large-scale motions through the addition of an ad hoc momentum memory term In this work, we combined these two complementary techniques and compared the results against conventional ReX formulations of molecular dynamics (MD) and Langevin dynamics (LD) simulations for the prediction of thermodynamic folding observables of the Trp-cage mini-protein. All simulations were performed with CHARMM using the PARAM22+CMAP force field and the generalized Born molecular volume implicit solvent model While SGLD-ReX does not fold up the protein significantly faster than the two conventional ReX approaches, there is some evidence that the method improves sampling convergence by reducing topological folding barriers between energetically similar near-native states. Unlike MD-ReX and LD-ReX, SGLD-ReX predicts melting temperatures, heat capacity curves, and folding free energies that are closer in agreement to the experimental observations. However, this favorable result may be due to distortions of the relative free energies of the folded and unfolded conformational basins caused by the ad hoc force term in the SGLD model. C1 [Lee, Michael S.] USA, Res Lab, Computat Sci & Engn Branch, Aberdeen Proving Ground, MD 21005 USA. [Lee, Michael S.] USA, Biotechnol High Performance Comp Software Applica, Med Res & Mat Command, Frederick, MD 21702 USA. [Lee, Michael S.; Olson, Mark A.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. RP Lee, MS (reprint author), USA, Res Lab, Computat Sci & Engn Branch, Aberdeen Proving Ground, MD 21005 USA. FU U S Department of Defense [3.10010_06_RD_B, TMT10004_09_BH_T] FX We would like to thank Dr. I -C Yell for supplying his WHAM code Funding for this research was provided by the U S Department of Defense Threat Reduction Agency Grants 3.10010_06_RD_B and TMT10004_09_BH_T, and the Department of Defense Biotechnology High Performance Computing Software Applications Institute Computational time was provided, in part. by the U S Army Research Laboratory Major Shared Resource Center and Maui High Performance Computing Center The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U S. Army or of the U S Department of Defense This paper has been approved for public release with unlimited distribution NR 48 TC 23 Z9 23 U1 1 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD AUG PY 2010 VL 6 IS 8 BP 2477 EP 2487 DI 10.1021/ct100062b PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 635NE UT WOS:000280661600021 PM 26613500 ER PT J AU Bernet, V AF Bernet, Victor TI Approach to the Patient with Incidental Papillary Microcarcinoma SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID DIFFERENTIATED THYROID-CARCINOMA; LYMPH-NODE METASTASIS; NECK ULTRASONOGRAPHY; CANCER; THYROGLOBULIN; DISEASE; SUPPRESSION; THERAPY; AUTOPSY; PERIOD AB Analysis of the Surveillance Epidemiology and End Results database reveals that since 1995 a 2.4-fold increase in thyroid cancer has occurred. A concomitant rise in cases of thyroid microcarcinoma has also been noted, with the frequency rising by approximately 50% as well. Increased detection of thyroid nodules, many of them below 1 cm in size, is at least partly responsible for this trend. The wide use of sensitive imaging modalities for various indications leads to the incidental discovery of thyroid nodules, some of which contain thyroid cancer, including cases of microcarcinoma. Although the vast majority of patients with thyroid cancer foci smaller than 1 cm will do exceedingly well long term, exceptions do occur, with some patients experiencing recurrence either locally or less frequently with distant metastasis. There has been some debate on the optimal management for these patients to include: extent of surgery required, the usefulness of ablation with radioactive iodine, as well as the optimal level for TSH suppression. In this article, we will review the available data and recommendations surrounding the management of patients with incidental thyroid microcarcinoma (J Clin Endocrinol Metab 95: 3586-3592, 2010) C1 Uniformed Serv Univ Hlth Sci, Endocrinol Diabet & Metab Serv, Walter Reed Army Med Ctr, Natl Capitol Consortium Endocrinol Fellowship, Washington, DC 20307 USA. RP Bernet, V (reprint author), Uniformed Serv Univ Hlth Sci, Endocrinol Diabet & Metab Serv, Walter Reed Army Med Ctr, Natl Capitol Consortium Endocrinol Fellowship, Bldg 2,Ward 7D, Washington, DC 20307 USA. EM vabernet@comcast.net NR 29 TC 26 Z9 28 U1 1 U2 5 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD AUG PY 2010 VL 95 IS 8 BP 3586 EP 3592 DI 10.1210/jc.2010-0698 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 635JW UT WOS:000280652400003 PM 20685885 ER PT J AU Liu, XY Wazne, M Han, Y Christodoulatos, C Jasinkiewicz, KL AF Liu, Xuyang Wazne, Mahmoud Han, Yun Christodoulatos, Christos Jasinkiewicz, Kristin L. TI Effects of natural organic matter on aggregation kinetics of boron nanoparticles in monovalent and divalent electrolytes SO JOURNAL OF COLLOID AND INTERFACE SCIENCE LA English DT Article DE Aggregation; Transport; Nanoparticles; Natural organic matter; Boron; Stabilization; Humic acid; Alginate; DLVO ID FULLERENE C-60 NANOPARTICLES; DEPOSITION KINETICS; CARBON NANOTUBES; POROUS-MEDIA; HUMIC-ACID; ENVIRONMENTAL IMPLICATIONS; HEMATITE NANOPARTICLES; TITANIUM-DIOXIDE; FULVIC-ACID; COLLOIDS AB Nano boron is a promising new propellant being considered for military and civilian applications; however, the impact of its release on the environment is largely not known. The early stage aggregation kinetics of boron nanoparticles was investigated in the presence of two kinds of natural organic matter Suwannee River humic acid (SRHA) and sodium alginate by dynamic light scattering and transmission electron microscopy (TEM). The addition of SRHA caused the boron nanoparticles to stabilize and resulted in (1) decreased attachment efficiency for the reaction-controlled regime and (2) an increase in the critical coagulation concentration, in CaCl(2) and MgCl(2) solutions. The increase in the electrostatic repulsion is suggested as a main cause of the induced stabilization as indicated by the electrophoretic mobility measurements. Similar behavior was observed in the presence of alginate and MgCl(2). However, the attachment efficiency kept increasing in the presence of CaCl2 and alginate with the increase in the electrolyte concentration and was greater than unity at >4 mM CaCl(2). The destabilization was attributed to bridging of the nanoparticles by the alginate-Ca(2+) system. Results from this study suggest that various NOM and electrolytes play significant and differing roles in the aggregation of boron nanoparticles in natural aquatic environments. (C) 2010 Elsevier Inc. All rights reserved. C1 [Liu, Xuyang; Wazne, Mahmoud; Christodoulatos, Christos] Stevens Inst Technol, Ctr Environm Syst, Keck Geotech Geoenvironm Lab, Hoboken, NJ 07030 USA. [Han, Yun] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. [Jasinkiewicz, Kristin L.] USA, Environm Technol Div, Picatinny Arsenal, NJ 07806 USA. RP Wazne, M (reprint author), Stevens Inst Technol, Ctr Environm Syst, Keck Geotech Geoenvironm Lab, Hoboken, NJ 07030 USA. EM mwazne@stevens.edu RI han, yun/C-1470-2011; Liu, Xuyang/F-3373-2011; han, yun/F-1588-2011 NR 47 TC 43 Z9 44 U1 3 U2 47 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9797 J9 J COLLOID INTERF SCI JI J. Colloid Interface Sci. PD AUG 1 PY 2010 VL 348 IS 1 BP 101 EP 107 DI 10.1016/j.jcis.2010.04.036 PG 7 WC Chemistry, Physical SC Chemistry GA 612SY UT WOS:000278924600012 PM 20483427 ER PT J AU Hullavarad, SS Hullavarad, NV Vispute, RD Venkatesan, T Kilpatrick, SJ Ervin, MH Nichols, B Wickenden, AE AF Hullavarad, S. S. Hullavarad, N. V. Vispute, R. D. Venkatesan, T. Kilpatrick, S. J. Ervin, M. H. Nichols, B. Wickenden, A. E. TI Catalyst-Free Direct Vapor-Phase Growth of Hexagonal ZnO Nanowires on alpha-Al2O3 SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Nanowires; ZnO; catalyst free; PL; CL ID PULSED-LASER DEPOSITION; ZINC-OXIDE NANOWIRES; THIN-FILMS; THERMAL EVAPORATION; OPTICAL-PROPERTIES; EPITAXIAL-GROWTH; ROOM-TEMPERATURE; MOCVD; NANOSTRUCTURES; NANOLASERS AB The evolution of ZnO nanowires has been studied under supersaturation of Zn metal species with and without a ZnO thin-film buffer layer on alpha-Al2O3 deposited by the pulsed laser ablation technique. The nanowires had diameters in the range of 30 nm to 50 nm and lengths in the range of 5 mu m to 10 mu m with clear hexagonal shape and [000 (1) over bar], [10 (1) over bar1], and [10 (1) over bar0] facets. X-ray diffraction (XRD) measurements indicated crystalline properties for the ZnO nanostructures grown on pulsed laser deposition (PLD) ZnO nucleation layers. The optical properties were analyzed by photoluminescence (PL) and cathodoluminescence (CL) measurements. The ZnO nanowires were found to emit strong ultraviolet (UV) light at 386 nm and weak green emission as observed by PL measurements. The stoichiometry of Zn and O was found to be close to 1 by x-ray photoelectron spectroscopy (XPS) measurements. The process-dependent growth properties of ZnO nanostructures can be harnessed for future development of nanoelectronic components including optically pumped lasers, optical modulators, detectors, electron emitters, and gas sensors. C1 [Hullavarad, S. S.; Hullavarad, N. V.] Univ Alaska, Off Elect Miniaturizat, Fairbanks, AK 99701 USA. [Vispute, R. D.; Venkatesan, T.] Univ Maryland, Ctr Nanophys & Appl Mat, College Pk, MD 20742 USA. [Kilpatrick, S. J.; Ervin, M. H.; Nichols, B.; Wickenden, A. E.] USA, Res Lab, Adelphi, MD 20783 USA. RP Hullavarad, SS (reprint author), Univ Alaska, Off Elect Miniaturizat, Fairbanks, AK 99701 USA. EM shiva.h@alaska.edu RI Venkatesan, Thirumalai/E-1667-2013 FU U.S. Army Research Laboratory [DAAD 179920078, DAAD 19-01-2-0010]; Defense Advanced Research Projects Agency (DARPA) at University of Alaska Fairbanks FX This research was supported by the Microelectronics Research Agreement (MICRA) DAAD 179920078 and Power and Energy Collaborative Technology Alliance (CTA) DAAD 19-01-2-0010 of the U.S. Army Research Laboratory. The authors (SSH and NVH) acknowledge financial support from the Defense Advanced Research Projects Agency (DARPA) at University of Alaska Fairbanks. NR 61 TC 1 Z9 1 U1 2 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2010 VL 39 IS 8 BP 1209 EP 1217 DI 10.1007/s11664-010-1251-z PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MV UT WOS:000279504900013 ER PT J AU Van Tassel, DC Owens, BD Wolf, JM AF Van Tassel, Dane Carlisle Owens, Brett D. Wolf, Jennifer Moriatis TI Incidence Estimates and Demographics of Scaphoid Fracture in the US Population SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME LA English DT Article DE Epidemiology; incidence; scaphoid ID EPIDEMIOLOGY AB Purpose The epidemiology of scaphoid fracture is based mostly on retrospective analyses of small population centers. The purpose of this study was to determine the incidence of scaphoid fractures in a large national population database. Methods The National Electronic Injury Surveillance System (NEISS) is a representative sample of patients that is weighted to provide estimates of various injuries in the United States presenting to emergency rooms. Data on wrist fractures obtained from NEISS were used to estimate the incidence of scaphoid fractures in the United States between 2002 and 2006. We could not distinguish true scaphoid fractures from suspected scaphoid fractures. Demographics, location, mechanism, and sports participation were also recorded. Results A total of 507 injuries coded as fractures of the scaphoid were identified in the database from 2002 to 2006. According to the methodology of the NEISS sample, this corresponds to an estimated 21,481 scaphoid fractures among 909,309 total wrist fractures nationwide (2.4%) and an estimated incidence of scaphoid fractures of 1.47 fractures per 100,000 person-years (95% confidence interval, 1.31-1.63). Conclusions The estimated incidence of scaphoid fractures using U.S. census data is an order of magnitude less than the estimates in prior studies. If the data represent both suspected and true fractures, the incidence of true scaphoid fractures is likely an order of magnitude less than our estimates. Young males and persons between 10 and 19 years of age are at highest risk for scaphoid fracture. (J Hand Surg 2010;35A:1242-1245. (C) 2010 Published by Elsevier Inc. on behalf of the American Society for Surgery of the Hand.) C1 [Wolf, Jennifer Moriatis] Univ Colorado, Sch Med, Dept Orthopaed Surg, Aurora, CO 80045 USA. Univ Arizona, Coll Med, Phoenix, AZ USA. US Mil Acad, Keller Army Commun Hosp, West Point, NY 10996 USA. RP Wolf, JM (reprint author), Univ Colorado, Sch Med, Dept Orthopaed Surg, 12641 E 17th Ave,Room 4602, Aurora, CO 80045 USA. EM jennifer.wolf@ucdenver.edu NR 12 TC 20 Z9 20 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0363-5023 J9 J HAND SURG-AM JI J. Hand Surg.-Am. Vol. PD AUG PY 2010 VL 35A IS 8 BP 1242 EP 1245 DI 10.1016/j.jhsa.2010.05.017 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 637MS UT WOS:000280822800001 PM 20684922 ER PT J AU Zeng, XB Barlage, M Castro, C Fling, K AF Zeng, Xubin Barlage, Mike Castro, Chris Fling, Kelly TI Comparison of Land-Precipitation Coupling Strength Using Observations and Models SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID ATMOSPHERIC MOISTURE; UNITED-STATES; TIME SCALES; WATER; CLIMATE; EVAPORATION; CYCLE; REANALYSIS; EUROPE; BUDGET AB Numerous studies have attempted to address the land-precipitation coupling, but scientists' understanding remains limited and discrepancies still exist from different studies. A new parameter Gamma is proposed here to estimate the land-precipitation coupling strength based on the ratio of the covariance between monthly or seasonal precipitation and evaporation anomalies (from their climatological means) over the variance of precipitation anomalies. The Gamma value is easy to compute and insensitive to the horizontal scales used; however, it does not provide causality. A relatively high Gamma is a necessary-but not sufficient-condition for a relatively strong land-precipitation coupling. A computation of Gamma values using two global reanalyses (ECMWF and NCEP), one regional reanalysis [North American Regional Reanalysis (NARR)], and observed precipitation along with Variable Infiltration Capacity (VIC)-derived evaporation data indicates that the land-precipitation coupling is stronger in summer and weaker in winter. The strongest coupling (i.e., hot spots) occurs over the western and central parts of North America, part of the Eurasia midlatitude, and Sahel in boreal summer and over most of Australia, Argentina, and South Africa in austral summer. The Community Climate System Model, version 3 (CCSM3) shows much higher Gamma values, consistent with the strong coupling shown by its atmosphere-land coupled components in previous studies. Its overall spatial pattern of Gamma values is not affected much over most regions by the doubling of CO2 in CCSM3. The Gamma values from the Regional Atmospheric Modeling System (RAMS) are more realistic than those from CCSM3; however, they are still higher than those from observations over North America. C1 [Zeng, Xubin; Castro, Chris] Univ Arizona, Dept Atmospher Sci, Tucson, AZ 85721 USA. [Barlage, Mike] Natl Ctr Atmospher Res, Appl Res Lab, Boulder, CO 80307 USA. [Fling, Kelly] USA, Aberdeen Test Ctr, Aberdeen Proving Ground, MD USA. RP Zeng, XB (reprint author), Univ Arizona, Dept Atmospher Sci, POB 210081, Tucson, AZ 85721 USA. EM xubin@atmo.arizona.edu OI Zeng, Xubin/0000-0001-7352-2764 FU NOAA [NA07NES4400002]; NASA [NNX09A021G] FX This work was supported by NOAA (Grant NA07NES4400002) and NASA (Grant NNX09A021G). Francina Dominguez and three anonymous reviewers are thanked for their insightful and helpful comments. NR 36 TC 24 Z9 24 U1 0 U2 11 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD AUG PY 2010 VL 11 IS 4 BP 979 EP 994 DI 10.1175/2010JHM1226.1 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 639EY UT WOS:000280955600009 ER PT J AU Bray, P Sokas, R Ahluwalia, J AF Bray, Patricia Sokas, Rosemary Ahluwalia, Jaspal TI Heat-Related Illnesses: Opportunities for Prevention SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material ID HEATSTROKE AB The Occupational Medicine Forum is prepared by the ACOEM Occupational and Environmental Medical Practice Committee and does not necessarily represent an official ACOEM position. The Forum is intended for health professionals and is not intended to provide medical or legal advice, including illness prevention, diagnosis or treatment, or regulatory compliance. Such advice should be obtained directly from a physician and/or attorney. Inquiries and contributions to the Forum should be forwarded to Joseph J. Schwerha, MD, MPH by e-mail at schwer@pitt.edu. C1 [Bray, Patricia; Sokas, Rosemary] Off Occupat Med, Occupat Safety & Hlth Adm, Washington, DC USA. [Ahluwalia, Jaspal] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Bray, P (reprint author), Off Occupat Med, Occupat Safety & Hlth Adm, Washington, DC USA. NR 13 TC 1 Z9 1 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD AUG PY 2010 VL 52 IS 8 BP 844 EP 845 DI 10.1097/JOM.0b013e3181ed4c36 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 637YZ UT WOS:000280856400011 PM 20697228 ER PT J AU Edwards, PC Hess, S Saini, T Norton, N AF Edwards, Paul C. Hess, Stephen Saini, Tarnjit Norton, Neil TI Twenty-Eight-Year-Old Woman With Recent Onset of Painful Oral Erosions SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID HISTOPLASMOSIS; PEMPHIGUS; TUMOR; DISEASE; UPDATE C1 [Edwards, Paul C.] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA. [Hess, Stephen] Creighton Univ, Dept Gen Dent, Sch Dent, Omaha, NE 68178 USA. [Saini, Tarnjit] USA, DENTAC, Brooke Army Med Ctr, San Antonio, TX USA. [Norton, Neil] Creighton Univ, Sch Dent, Dept Oral Biol, Omaha, NE 68178 USA. RP Edwards, PC (reprint author), Univ Michigan, Sch Dent, Dept Periodont & Oral Med, 1011 N Univ Ave, Ann Arbor, MI 48109 USA. EM paulce@umich.edu OI Edwards, Paul/0000-0001-7884-8480 NR 22 TC 0 Z9 1 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD AUG PY 2010 VL 68 IS 8 BP 1890 EP 1895 DI 10.1016/j.joms.2009.06.040 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 635TT UT WOS:000280680200028 PM 20417592 ER PT J AU Piccione, MJ Manganaro, AM Almony, JS AF Piccione, Michael J. Manganaro, Albert M. Almony, Jeffrey S. TI Caliber-Persistent Labial Artery: Diagnosis and Treatment-Case Report SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID LOWER LIP; CANCER C1 [Piccione, Michael J.; Manganaro, Albert M.; Almony, Jeffrey S.] Womack Army Med Ctr, Dept Oral & Maxillofacial Surg, Ft Bragg, NC 28310 USA. RP Piccione, MJ (reprint author), Womack Army Med Ctr, Dept Oral & Maxillofacial Surg, Bldg 4-2817,Box 281, Ft Bragg, NC 28310 USA. EM michael.piccione@us.army.mil NR 9 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD AUG PY 2010 VL 68 IS 8 BP 1987 EP 1989 DI 10.1016/j.joms.2009.05.433 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 635TT UT WOS:000280680200040 PM 19954876 ER PT J AU Dorko, BL Falls, C Silvernail, JL AF Dorko, Barrett L. Falls, Cuyahoga Silvernail, Jason L. TI Manual Magic: The Method Is Not the Trick SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Letter ID LOW-BACK-PAIN; SPINAL MANIPULATIVE THERAPY; RANDOMIZED CLINICAL-TRIAL; MUSCULOSKELETAL PAIN; EXERCISE C1 [Dorko, Barrett L.; Falls, Cuyahoga; Silvernail, Jason L.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Dorko, BL (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 11 TC 0 Z9 0 U1 0 U2 1 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2010 VL 40 IS 8 BP 535 EP 536 PG 2 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 639IM UT WOS:000280968500011 PM 20710090 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Dmitry Shkuratov, Yuriy Videen, Gorden TI The Sh-matrix method applied to light scattering by two merging spheroids SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Light scattering; T matrix; Shape matrix; Spheroid ID T-MATRIX; NONSPHERICAL PARTICLES; ELECTROMAGNETIC SCATTERING; OSCULATING SPHERES; FINITE-CYLINDER; CLUSTERS; ENSEMBLES; COMPUTATIONS; BISPHERES; CAPSULE AB The Sh- (shape) matrix contains the morphology-dependent parameters that can be incorporated with the size- and refractive-index-dependent parameters to form the T-matrix using analytical operations. In some instances, the integrals that describe the Sh-matrix are simplified sufficiently that they may be solved analytically. In this manuscript we use the Sh-matrix formalism to present an analytical solution for the light scattering from two merging prolate and oblate spheroids. Such a solution has relevance in environmental monitoring of spores, whose morphology is approximately spheroidal and often form end-on chains. Published by Elsevier Ltd. C1 [Petrov, Dmitry; Shkuratov, Yuriy] Kharkov VN Karazin Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. [Shkuratov, Yuriy] Natl Acad Sci Ukraine, Inst Radioastron, UA-61002 Chervonopraporna 4, Ukraine. [Videen, Gorden] AMSRD ARL CI EM, Army Res Lab, Adelphi, MD 20783 USA. RP Petrov, D (reprint author), Kharkov VN Karazin Natl Univ, Astron Inst, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM petrov@astron.kharkov.ua; gvideen@arl.army.mil FU Army Medical Research Institute of Chemical Defense [W911NF-07-D-0001] FX This work was supported by the Army Medical Research Institute of Chemical Defense (Lucille Lumley, PhD) under the auspices of the US Army Research Office Scientific Services Program administered by Battelle (Delivery Order 0378, Contract no. W911NF-07-D-0001). NR 38 TC 7 Z9 7 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD AUG PY 2010 VL 111 IS 12-13 BP 1990 EP 1999 DI 10.1016/j.jqsrt.2010.04.005 PG 10 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 620PO UT WOS:000279512000011 ER PT J AU Geibel, JJ Demartini, JD Haaker, PL Karpov, K AF Geibel, John J. Demartini, John. D. Haaker, Peter L. Karpov, Konstantin TI GROWTH OF RED ABALONE, HALIOTIS RUFESCENS (SWAINSON), ALONG THE NORTH COAST OF CALIFORNIA SO JOURNAL OF SHELLFISH RESEARCH LA English DT Article DE red abalone; growth; Haliotis rufescens; von Bertalanffy; California; bootstrap AB Red abalone, Haliotis rufescens (Swainson), were tagged and recovered for growth and movement studies in northern California. Tagging and recoveries were conducted at north Point Cabrillo and south Point Cabrillo from 1971 through 1976 (no tagging or recoveries at south Point Cabrillo in 1973 and 1974), at Van Damme State Park from 1973 through 1975, and at Stornetta Ranch and Pedotti Ranch in 1975 and 1976. Von Bertalanffy growth curves were fit by area and year. Growth was found to vary by year and by study site. Fitted L(inf) range was from 184-232 mm, and age at legal sport size ranged from 8-20 y. The fasted growth rates were observed at north Point Cabrillo. C1 [Geibel, John J.] Calif Dept Fish & Game, Menlo Pk, CA 94025 USA. [Demartini, John. D.] Humboldt State Univ, Arcata, CA 95521 USA. [Haaker, Peter L.] Calif Dept Fish & Game, Westminster, CA 92683 USA. [Karpov, Konstantin] Karpov Marine Biol Res, Ft Bragg, CA 95437 USA. RP Geibel, JJ (reprint author), Calif Dept Fish & Game, 425 Cent Ave, Menlo Pk, CA 94025 USA. EM geibel@sbcglobal.net NR 15 TC 0 Z9 0 U1 3 U2 8 PU NATL SHELLFISHERIES ASSOC PI GROTON PA C/O DR. SANDRA E. SHUMWAY, UNIV CONNECTICUT, 1080 SHENNECOSSETT RD, GROTON, CT 06340 USA SN 0730-8000 J9 J SHELLFISH RES JI J. Shellfish Res. PD AUG PY 2010 VL 29 IS 2 BP 441 EP 448 DI 10.2983/035.029.0221 PG 8 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 632UY UT WOS:000280455700021 ER PT J AU Kimberley, J Lambros, J Chasiotis, I Pulskamp, J Polcawich, R Dubey, M AF Kimberley, J. Lambros, J. Chasiotis, I. Pulskamp, J. Polcawich, R. Dubey, M. TI Mechanics of energy transfer and failure of ductile microscale beams subjected to dynamic loading SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Article DE MEMS; Cantilever beams; Shock loading; Plastic hinge; Contact ID FREESTANDING GOLD-FILMS; POLYCRYSTALLINE SILICON; POLYSILICON FILMS; TENSILE BEHAVIOR; GRAINED FILMS; MEMS; STRENGTH; FATIGUE; RELIABILITY; SPALLATION AB The mechanical response of microelectromechanical systems (MEMS) under impulse loading conditions has not been thoroughly studied to date, partially because of the lack of means to provide such extreme loading rates to miniature devices. However, the increasing use of MEMS-based sensors and actuators in adverse environments, which include extreme strain rate loading, has motivated the investigation of the response of MEMS components under these conditions. In this work, basic and mostly commonly employed Au MEMS components were subjected to impulse loads of 40 ns in duration, which were generated by a high power pulsed laser in order to achieve acceleration levels on the order of 10(9)g. This allowed for the microdevice mechanical/structural response to be investigated at time scales that were of the order of wave transit times in the substrate and the devices. Basic microscale structures, such as cantilevers and fixed-fixed beams of uniform cross-section, were employed to facilitate comparisons with companion finite element simulations in order to gain insight into the mechanisms responsible for impulsive deformation at the microscale. The simulations investigated the effect of loading rate, boundary conditions, beam length, material constitutive response, and damping on the final deformed shapes of the beams. It was found that contact and momentum transfer mechanisms were responsible for the large permanent beam deflections which were measured postmortem. Additionally, the effects of both damping and material property rate dependence were found to be dominant in determining the final deformed shape of the beams. In fact, our observations suggest that the contributions of material rate dependence and damping are not simply additive, but rather involve a coupling between them that affects the final structure response. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Kimberley, J.; Lambros, J.; Chasiotis, I.] Univ Illinois, Urbana, IL 61801 USA. [Pulskamp, J.; Polcawich, R.; Dubey, M.] USA, Res Labs, Adelphi, MD USA. RP Lambros, J (reprint author), Univ Illinois, Urbana, IL 61801 USA. EM lambros@illinois.edu FU Army Research Office (ARO) [W911NF-05-1-0063]; National Science Foundation [CMS-0555787]; US Department of Energy [DEFG02-91-ER45439] FX The authors would like to acknowledge the support of the Army Research Office (ARO) under the Grant W911NF-05-1-0063 with Dr. Bruce LaMattina as the program manager, and the support by the National Science Foundation under Grant CMS-0555787. Electron microscopy was carried out in the Center for Microanalysis of Materials, University of Illinois, which is partially supported by the US Department of Energy under Grant DEFG02-91-ER45439. The authors would also like to thank Richard Piekarz, John Conrad, and Joel Martin of the Army Research Laboratory along with Prashant Ranade of General Technical Services for their assistance in the fabrication of the MEMS devices. NR 30 TC 3 Z9 3 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-5096 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD AUG PY 2010 VL 58 IS 8 BP 1125 EP 1138 DI 10.1016/j.jmps.2010.04.005 PG 14 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA 620PQ UT WOS:000279512200005 ER PT J AU Roppo, V Ciraci, C Cojocaru, C Scalora, M AF Roppo, V. Ciraci, C. Cojocaru, C. Scalora, M. TI Second harmonic generation in a generic negative index medium SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID LEFT-HANDED METAMATERIALS; MAGNETIC METAMATERIALS; OPTICAL METAMATERIALS; REFRACTION; PROPAGATION AB We analyze second harmonic generation in a generic medium composed of Lorentz oscillators for both the electrical permittivity and magnetic permeability. We discuss conditions where a fundamental beam is tuned in a positive index region and generates second and/or third harmonics in a negative index region. Phase matching condition, phase locking, inhibition of absorption at the harmonic wavelengths, and second and third harmonic lenses are also investigated. (C) 2010 Optical Society of America C1 [Roppo, V.; Cojocaru, C.] Univ Politecn Cataluna, Dept Fis & Eng Nucl, E-08222 Terrassa, Spain. [Roppo, V.; Scalora, M.] USA, CM Bowden Res Facil, RDECOM, Redstone Arsenal, AL 35803 USA. [Ciraci, C.] Univ Montpellier 2, F-34095 Montpellier, France. RP Roppo, V (reprint author), Univ Politecn Cataluna, Dept Fis & Eng Nucl, Colom 11, E-08222 Terrassa, Spain. EM vito.roppo@upc.edu RI roppo, vito/D-9639-2012 OI roppo, vito/0000-0003-0928-4209 FU Spanish Government [FIS06024-C03-02]; Catalan Government [2009 SGR 1168]; COST Action [MP0702]; Army Research Laboratory, London [W911NF-09-1-0144] FX This work was partially supported by the Spanish Government (FIS06024-C03-02), Catalan Government (2009 SGR 1168), the COST Action MP0702, and the Army Research Laboratory, London (W911NF-09-1-0144). The authors thank R. Vilaseca and J. Trull for helpful support and collaboration. NR 31 TC 8 Z9 8 U1 1 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD AUG PY 2010 VL 27 IS 8 BP 1671 EP 1679 PG 9 WC Optics SC Optics GA 635OP UT WOS:000280665300024 ER PT J AU Wade, CE Eastridge, BJ Jones, JA West, SA Spinella, PC Perkins, JG Dubick, MA Blackbourne, LH Holcomb, JB AF Wade, Charles E. Eastridge, Brian J. Jones, John A. West, Susan A. Spinella, Philip C. Perkins, Jeremy G. Dubick, Michael A. Blackbourne, Lorne H. Holcomb, John B. TI Use of Recombinant Factor VIIa in US Military Casualties for a Five-Year Period SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 68th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY OCT 01-03, 2009 CL Pittsburgh, PA SP Amer Assoc Surg Trauma DE Mortality; Complications; Transfusion; Admission physiology; Coagulopathy ID ACTIVATED FACTOR-VII; TRANSFUSED TRAUMA PATIENTS; COMBAT-RELATED CASUALTIES; FRESH WHOLE-BLOOD; MASSIVE TRANSFUSION; EARLY COAGULOPATHY; MORTALITY; SURVIVAL; DEATHS; PLASMA AB Background: Two prospective randomized trauma trials have shown recombinant factor VIIa (rFVIIa) to be safe and to decrease transfusion requirements. rFVIIa is presently used in 22% of massively transfused civilian trauma patients. The US Military has used rFVIIa in combat trauma patients for five years, and two small studies of massively transfused patients described an association with improved outcomes. This study was undertaken to assess how deployed physicians are using rFVIIa and its impact on casualty outcomes. Methods: US combat casualties (n = 2,050) receiving any blood transfusion from 2003 to 2009 were reviewed to compare patients receiving rFVIIa (n = 506) with those who did not (n = 1,544). Propensity-score matching (primary analysis) and multivariable logistic regression were used to compare outcomes. Differences were determined at p < 0.05. Results: Twenty-five percent of patients received rFVIIa. Significant differences were noted between groups in indices of injury severity (Injury Severity Score, Abbreviated Injury Scale score, and Glasgow Coma Scale score), admission physiology (systolic blood pressure, diastolic blood pressure, heart rate, temperature, base deficit, hemoglobin, and international normalization ratio), and use of blood products, indicating that patients treated with rFVIIa were more severely injured, in shock, and coagulopathic. For propensity-score matching, factors associated with death were used: Injury Severity Score, Glasgow Coma Scale score, heart rate, systolic blood pressure, diastolic blood pressure, Hgb, and total packed red blood cell. A total of 266 patients per group were matched; 52% of the rFVIIa group. After pairing, there were no significant differences in any of the demographics, including incidence of massive transfusion (53% vs. 51%). There was no difference in the rate of complications (21% vs. 21%) or mortality (14% vs. 20%) for patients not treated or receiving rFVIIa, respectively. Conclusion: In military casualties, rFVIIa is used in the most severely injured patients based on physician selection rather than on guideline criteria. Use of rFVIIa is not associated with an improvement in survival or an increase in complications. The undetected bias of physician selection of patients for treatment with rFVIIa, likely, has an impact on case matching to achieve equivalence similar to that of randomized control studies. This inability to match populations, thus, prevents definitive interpretation of this study and others studies of similar design. This problem emphasizes the need to develop entry criteria to identify patients who could potentially benefit from use of rFVIIa and the need to subsequently perform efficacy studies. C1 [Wade, Charles E.; Holcomb, John B.] Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, Houston, TX USA. [Wade, Charles E.; Holcomb, John B.] Univ Texas Hlth Sci Ctr, Dept Surg, Houston, TX USA. [Wade, Charles E.; Eastridge, Brian J.; Jones, John A.; West, Susan A.; Spinella, Philip C.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Dept Hematol, Bethesda, MD USA. [Spinella, Philip C.] Univ Connecticut, Dept Pediat, Hartford, CT 06112 USA. [Spinella, Philip C.] Univ Connecticut, Dept Surg, Hartford, CT 06112 USA. RP Wade, CE (reprint author), Univ Texas Hlth, Ctr Translat Injury Res, 6431 Fannin,MSB 5-206, Houston, TX 77030 USA. EM Charles.E.Wade@uth.tmc.edu NR 49 TC 26 Z9 26 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2010 VL 69 IS 2 BP 353 EP 358 DI 10.1097/TA.0b013e3181e49059 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 638JN UT WOS:000280890800023 PM 20699744 ER PT J AU Batchinsky, AI Cancio, LC AF Batchinsky, Andriy I. Cancio, Leopoldo C. TI Response to the Letter to the Editor Entitled "Heart Period Variability Monitoring in Trauma and Hemorrhage" Reply SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Letter C1 [Batchinsky, Andriy I.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2010 VL 69 IS 2 BP 480 EP 480 DI 10.1097/TA.0b013e3181e81088 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 638JN UT WOS:000280890800051 ER PT J AU Grubb, TG Delaney, DK Bowerman, WW Wierda, MR AF Grubb, Teryl G. Delaney, David K. Bowerman, William W. Wierda, Michael R. TI Golden Eagle Indifference to Heli-Skiing and Military Helicopters in Northern Utah SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article DE aircraft; buffers; golden eagle; helicopter; heli-skiing; human disturbance; management; military; noise; recreation ID LEVEL JET AIRCRAFT; HUMAN DISTURBANCE; BALD EAGLES; RESPONSES; RAPTORS; NOISE; RECOMMENDATIONS; BEHAVIOR AB In 2006-2007, during Wasatch Powderbird Guides (WPG) permit renewal for heli-skiing in the Tri-Canyon Area (TCA) of the Wasatch Mountains, Utah, USA, we recorded 303 helicopter passes between 0 m and 3,000 m (horizontal distance) near >= 30 individual golden eagles (Aquila chrysaetos) in 22 nesting territories, through passive observation and active experimentation with civilian and military (Apache AH-64) helicopters. Flight profiles included 800-m, 400-m, 200-m, and 100-m flybys (horizontal distance from cliff nest on parallel course), as well as approaches and popouts where helicopters flew toward, or popped out from behind, adult-occupied cliff nests (0 m, horizontal distance). Between 1981 and 2007, during the only 8 years when nesting in the TCA was confirmed by presence of chicks, WPG annually flew 108-2,836 helicopter flights in the same drainages on 10-37 days between 15 December and 15 April, with no effect on early courtship, nest repair, or subsequent nesting success. Total WPG operating days (x = 62.4) and helicopter hours (x = 210.6) fluctuated annually but did not increase 1974-2007 (Cox-Stuart trend test, P = 0.371, 0.393, respectively). Apache helicopter testing (227 passes) did not reduce golden eagle nesting success or productivity rates within the same year (t(111,) (96) = 0.495, 0.782, P = 0.622, 0.436, respectively), or rates of renewed nesting activity the following year, compared with 81-101 non-manipulated nesting territories. We recorded no response during 66% and only watching during 30% of Apache passes at 0-800 m from nesting golden eagles. No other reactions occurred until after hatching when <= 4 golden eagles accounted for 5 flatten and 3 fly behaviors at 3 nest sites. No responding pairs failed to fledge young because of testing. Limited fly responses suggested helicopters only precipitated an imminent departure, rather than causing startled, avoidance reactions. Responsiveness between test weeks 1 and 2 decreased (chi(2)(2) - 32.167, P <= 0.001). Apache helicopters were twice as loud as WPG helicopters at comparable distances. Sound decreased with distance, most rapidly when flights were perpendicular to cliffs or ridges. Eagle ambient behaviors and watching the helicopter occurred randomly throughout recorded sound levels during helicopter testing (76.7-108.8 decibels, unweighted). Much helicopter sound energy is below golden eagles' auditory threshold, thus reducing potential impacts. Neither our observations nor our testing indicated special management restrictions are required for helicopters flying near nesting golden eagles in northern Utah. Our results underscore the necessity for circumstance-specific research, as well as enlightened resource management to accommodate unexpected results. C1 [Grubb, Teryl G.] US Forest Serv, Rocky Mt Res Stn, Flagstaff, AZ 86001 USA. [Delaney, David K.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. [Bowerman, William W.; Wierda, Michael R.] Clemson Univ, Dept Forestry & Nat Resources, Clemson, SC 29634 USA. RP Grubb, TG (reprint author), US Forest Serv, Rocky Mt Res Stn, 2500 S Pine Knoll Dr, Flagstaff, AZ 86001 USA. EM tgrubb@fs.fed.us RI Jenkins, Stephanie/F-5216-2011 FU USFS; Rocky Mountain Research Station; WCNF; United States Army Engineer Research and Development Center, Construction Engineering Research Laboratory; Department of Forestry and Natural Resources, Clemson University FX This research project was jointly funded by the USFS, Rocky Mountain Research Station and WCNF; United States Army Engineer Research and Development Center, Construction Engineering Research Laboratory; and Department of Forestry and Natural Resources, Clemson University. In addition, the WCNF Supervisor's Office and Salt Lake Ranger District, especially D. Probasco, R. Williams, S. Scheid, and J. Walkes, provided logistical and administrative support throughout the project. Helicopter testing was made possible by the Utah National Guard and the special assistance of Senior Pilots CW5 D. Jacobson and CW3 M. Pluim. R. Dassing, M. Olson, and K. O'Rourke of WPG provided historical insight, access to operational records, and helicopter support for several surveys and experimental test flights. Classic Helicopters Head Pilot, M. Nicolette, and Cirque Lodge's Pilot, A. Oprie, arranged for sound testing of their respective helicopters, plus the Cirque helicopter facilitated experimental data collection at 2 additional sites. K. Keller, local raptor specialist and golden eagle expert, provided current and historical nesting data, and monitored manipulated and non-manipulated sites each year. Individuals who recorded helicopter test observations at golden eagle nests include A. Gatto, K. Hartman, D. Johnson, K. Keller, R. Lopez, B. Piscapo, D. Probasco, S. Scheid, C. Smith, Z. Todd, and R. Williams. We thank D. Ellis, D. Garcelon, and M. Kochert for constructively reviewing this manuscript. NR 46 TC 3 Z9 3 U1 3 U2 20 PU WILDLIFE SOC PI BETHESDA PA 5410 GROSVENOR LANE, BETHESDA, MD 20814-2197 USA SN 0022-541X J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD AUG PY 2010 VL 74 IS 6 BP 1275 EP 1285 DI 10.2193/2009-337 PG 11 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 630ZT UT WOS:000280316700013 ER PT J AU Sanamyan, T Simmons, J Dubinskii, M AF Sanamyan, T. Simmons, J. Dubinskii, M. TI Efficient cryo-cooled 2.7-mu m Er3+:Y2O3 ceramic laser with direct diode pumping of the upper laser level SO LASER PHYSICS LETTERS LA English DT Article DE sesquioxide laser ceramic; Er-doped crystal; multiphonon nonradiative decay; low phonon laser host ID MU-M; TEMPERATURE; EMISSION; Y2O3 AB Reported here is the first cryogenically-cooled performance of Er3+ -doped Y2O3 laser based on I-4(11/2) -> I-4(13/2) transitions. Laser material was diode-pumped directly into an upper laser manifold I-4(11/2) in order to minimize quantum defect of this Mid-IR laser. CW output power of over 1.6 W at similar to 2.7 mu m was achieved with the 27.5% slope efficiency, which is approaching the quantum defect-limited efficiency value despite the marginal optical quality of the available laser sample. C1 [Sanamyan, T.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA. [Simmons, J.] Utah State Univ, Logan, UT 84322 USA. RP Dubinskii, M (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil NR 12 TC 28 Z9 29 U1 2 U2 15 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1612-2011 EI 1612-202X J9 LASER PHYS LETT JI Laser Phys. Lett. PD AUG PY 2010 VL 7 IS 8 BP 569 EP 572 DI 10.1002/lapl.201010031 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA 653NP UT WOS:000282098700003 ER PT J AU Florio, LA AF Florio, L. A. TI Effect of vent opening area and arrangement on gas flow field as gas propelled cylinder exits a flow tube SO MECCANICA LA English DT Article DE Computational; Fluid flow; Compressible; Moving body; Vent openings ID NUMERICAL-SIMULATION; SCHEME AB The effects of auxiliary flow tube vent opening area and arrangement on the gas flow field as a gas propelled cylinder exits a flow tube were studied numerically. Configurations with a single opening of increasing size and multiple opening arrangements with equivalent opening area were considered for comparison to a baseline no-opening system. The openings are positioned near the end of the flow tube. The intended use of the openings is to reduce the pressures of the gases escaping to the surroundings and thus to reduce the intensity and size of the gas expansion zone in the surroundings. The results indicated that increasing the opening flow area decreased the pressure at the axial end of the flow tube and the radial extent of the end of flow tube exit plume. However, the radially directed flow streams leaving through the side vent openings could increase the overall radial spread of the gas expansion into the surroundings. The single opening arrangement produced as much as a 95% decrease in the pressure at the end of the flow tube and a 37% decrease in the recoil force at a given time with about 95% of the exiting flow leaving through the opening. For the parameters considered, the multiple opening arrangement produced up to a 93% decrease in the pressure at the end of the flow tube and a 90% decrease in the recoil force at a given time with about 93% of the exiting flow leaving through the openings. The results showed larger single openings to be more effective at reducing end of flow tube pressure, while the multiple openings to be more conducive to a reduced recoil force. C1 USA, Technol Branch, Small & Medium Caliber Armaments Div, RDAR WSW F,ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Florio, LA (reprint author), USA, Technol Branch, Small & Medium Caliber Armaments Div, RDAR WSW F,ARDEC, Bldg 65N, Picatinny Arsenal, NJ 07806 USA. EM laurie.florio@us.army.mil FU In-House Laboratory [AR-0101975/FJ5R] FX This work was funded by the In-House Laboratory Independent Research Program- AR-0101975/FJ5R. The author wishes to acknowledge D. Cler and US ARMY Armaments Research, Development and Engineering Center's Benet Labs, Watervliet, New York and D. Cler for assistance and usage of FLUENT licenses. NR 31 TC 3 Z9 4 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0025-6455 J9 MECCANICA JI Meccanica PD AUG PY 2010 VL 45 IS 4 BP 475 EP 501 DI 10.1007/s11012-009-9266-3 PG 27 WC Mechanics SC Mechanics GA 632EM UT WOS:000280403700003 ER PT J AU Tunick, A AF Tunick, Arnold TI Numerical experiment to revisit micrometeorology and sound speed calculations in forests SO METEOROLOGY AND ATMOSPHERIC PHYSICS LA English DT Article AB A recent paper (Tunick and Swearingen in Appl Acoustics 70:857-867, 2009) presented a finite-difference computer model to calculate the microphysical influences on sound wave propagation in forests. Several numerical tests were conducted to assess model code capabilities using micrometeorological and acoustic field data. Calculated wind, temperature, and specific humidity profile data compared favorably to measured data. Nevertheless, we recommended investigation of alternate numerical schemes to determine the best formulation for micrometeorological-acoustic research applications in forests. Hence, in this paper, we conduct a numerical experiment that focuses on the pressure gradient term in the conservation of momentum equation. In particular, we implement a numerical iteration of this term at each time step of the calculation. This modification yields a more nearly incompressible flow, thus producing an alternative representation of the physics for the simulation of interest. Differences in the computed wind, temperature, and sound speed fields for the runs with and without implementing the iteration scheme are illustrated graphically and discussed. C1 USA, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Tunick, A (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM arnold.tunick@us.army.mil FU US Army Engineer Research and Development Center (ERDC); Army Research Laboratory (ARL) FX The author gratefully acknowledges the editor and the anonymous reviewers for providing helpful comments on the manuscript. The author also extends thanks to Ronald Meyers of the Army Research Laboratory (ARL) for providing many helpful discussions on CFD models and numerical methods. Partial funding for this study was provided by the US Army Engineer Research and Development Center (ERDC) and ARL. NR 13 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0177-7971 J9 METEOROL ATMOS PHYS JI Meteorol. Atmos. Phys. PD AUG PY 2010 VL 107 IS 3-4 BP 103 EP 108 DI 10.1007/s00703-010-0072-1 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 632ER UT WOS:000280404300003 ER PT J AU De Lorenzo, RA AF De Lorenzo, Robert A. TI Checking the Box on Training Tasks SO MILITARY MEDICINE LA English DT Editorial Material C1 [De Lorenzo, Robert A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [De Lorenzo, Robert A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. RP De Lorenzo, RA (reprint author), Brooke Army Med Ctr, Dept Clin Invest, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2010 VL 175 IS 8 BP 544 EP 547 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 632VB UT WOS:000280456000003 PM 20731256 ER PT J AU Guerrero, AF Alfonso, A AF Guerrero, Arthur F. Alfonso, Abel TI Traumatic Brain Injury-Related Hypopituitarism: A Review and Recommendations for Screening Combat Veterans SO MILITARY MEDICINE LA English DT Article ID ANTERIOR-PITUITARY FUNCTION; DIABETES-INSIPIDUS; STALK RUPTURE; ACUTE-PHASE; DYSFUNCTION; INSUFFICIENCY; CHILD AB Recent civilian data obtained in those sustaining head injuries, has found a high prevalence of pituitary dysfunction. Currently, there is no data available in the military population. We reviewed the literature for traumatic brain injury (TBI)-related hypopituitarism and found that the prevalence of anterior hypopituitarism may be as high as 30-80% after 24-36 months. Since many of the symptoms of hypopituitarism are similar to those of TBI, it is important to make clinicians caring for combat veterans aware of its occurrence. Herein, we provide an overview of the literature and recommendations for hormonal testing when TBI-related hypopituitarism is suspected. C1 [Guerrero, Arthur F.; Alfonso, Abel] Walter Reed Army Med Ctr, Dept Internal Med, Endocrinol Diabet & Metab Serv, Washington, DC 20307 USA. RP Guerrero, AF (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, Endocrinol Diabet & Metab Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 31 TC 16 Z9 16 U1 5 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2010 VL 175 IS 8 BP 574 EP 580 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 632VB UT WOS:000280456000008 PM 20731261 ER PT J AU Shen-Gunther, J Shank, JJ AF Shen-Gunther, Jane Shank, Jessica J. TI Nerve-Sparing Radical Hysterectomy Using Modern Bipolar Electrosurgical Instruments Based on the ForceTriad Energy Platform SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Annual Meeting of the Armed Forces District of the American-College-of-Obstetricians-and-Gynecologists CY OCT 12-15, 2008 CL Norfolk, VA SP Amer Coll Obstetricians & Gynecologists, Armed Forces Dist ID CERVICAL-CANCER; COMPLICATIONS; DISSECTION; RECURRENCE; SURGERY; IIA AB Objective: To describe and evaluate a novel technique of nerve-sparing radical abdominal hysterectomy with pelvic lymphadenectomy (NSRH/PLND) using the bipolar Ligasure Atlas sealer/divider and Bissenger bipolar shears. Methods: Retrospective study of 4 consecutive patients who underwent NSRH/PLND for stage IB1-IIB cervical carcinoma was conducted. Resection of the cardinal and uterosacral ligaments was performed with the Ligasure Atlas. Pelvic autonomic nerve dissection and lymphadenectomy were completed with the bipolar shears. Outcomes were collectively analyzed. Results: Mean operative time was 251 minutes (range, 230-265). Blood loss averaged 625 mL (range, 400-900). Average LOS was 5 days (range, 4-5). Average duration until normal postvoid residual volume was 17 days (range, 10-24). No perioperative complications were encountered. Conclusion: Bipolar surgical instrumentation offers many advantages. The Ligasure Atlas provides efficient sealing and division of vascular pedicles, while the bipolar shears allow precise and fine dissection. Our results demonstrate the "bipolar sealer and shears technique" a preferable method of NSRH/PLND. C1 [Shen-Gunther, Jane] USN, San Diego Med Ctr, Gynecol Oncol Serv, San Diego, CA 92134 USA. [Shen-Gunther, Jane] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Shank, Jessica J.] USN, San Diego Med Ctr, Dept Obstet & Gynecol, San Diego, CA 92134 USA. RP Shen-Gunther, J (reprint author), USN, San Diego Med Ctr, Gynecol Oncol Serv, 34800 Bob Wilson Dr, San Diego, CA 92134 USA. NR 23 TC 4 Z9 4 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2010 VL 175 IS 8 BP 610 EP 615 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 632VB UT WOS:000280456000014 PM 20731267 ER PT J AU Kleyensteuber, B Ruterbusch, V Bennett, J Llewellyn, D Loeffler, G AF Kleyensteuber, Brian Ruterbusch, Victor Bennett, Jason Llewellyn, David Loeffler, George TI Limbic Encephalitis Presenting With Seizures, Anterograde Amnesia, and Psychosis in a Patient Seven Weeks Status Post Immature Ovarian Teratoma Removal SO MILITARY MEDICINE LA English DT Article ID PARANEOPLASTIC ENCEPHALITIS; RECEPTOR ANTIBODIES AB A paraneoplastic syndrome associated with anti-N-methyl-D-asparate (NMDA) receptors can initially present as a neurologic or psychiatric disturbance. Removal of the tumor is usually curative, and the syndrome is associated with the presence, rather than the history, of tumor. We present a case in which a 25-year-old, Hispanic woman presented with seizures, memory loss, and unusual behavioral changes. The woman had a teratoma removed 2 months earlier. Because of the time course, a paraneoplastic syndrome was initially considered unlikely. Brain imaging, electroencephalography (EEG) and neurologic work-up were negative. The patient was treated for a suspected somatoform disorder and psychosis. Based on the clinical picture, the working diagnosis was changed to delirium due to paraneoplastic limbic encephalitis. A course of intravenous immunoglobins (IVIg), and high dose steroids was administered. The patient's symptoms improved, and she was discharged home. After discharge, studies came back positive for antibodies against NR1/NR2 of the NMDA receptor. C1 [Kleyensteuber, Brian; Bennett, Jason; Loeffler, George] USN, San Diego Med Ctr, Dept Mental Hlth, San Diego, CA 92134 USA. [Llewellyn, David] USN, San Diego Med Ctr, Dept Neurol, San Diego, CA 92134 USA. [Ruterbusch, Victor] Tripler Army Med Ctr, Dept Mental Hlth, Honolulu, HI 96859 USA. RP Kleyensteuber, B (reprint author), USN, San Diego Med Ctr, Dept Mental Hlth, 34800 Bob Wilson Dr, San Diego, CA 92134 USA. NR 18 TC 7 Z9 7 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2010 VL 175 IS 8 BP 616 EP 618 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 632VB UT WOS:000280456000015 PM 20731268 ER PT J AU Reed, A Dent, M Lewis, S Shogan, P Folio, L AF Reed, Aaron Dent, Michael Lewis, Steve Shogan, Paul Folio, Les TI Answer to Last Month's Radiology Case and Image: Hydropneumothorax SO MILITARY MEDICINE LA English DT Editorial Material C1 [Reed, Aaron; Dent, Michael; Lewis, Steve; Folio, Les] Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA. [Shogan, Paul] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Reed, A (reprint author), Uniformed Serv Univ Hlth Sci, Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2010 VL 175 IS 8 BP 625 EP 626 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 632VB UT WOS:000280456000018 PM 20731271 ER PT J AU Grant-Klein, RJ Baldwin, CD Turell, MJ Rossi, CA Li, F Lovari, R Crowder, CD Matthews, HE Rounds, MA Eshoo, MW Blyn, LB Ecker, DJ Sampath, R Whitehouse, CA AF Grant-Klein, Rebecca J. Baldwin, Carson D. Turell, Michael J. Rossi, Cynthia A. Li, Feng Lovari, Robert Crowder, Chris D. Matthews, Heather E. Rounds, Megan A. Eshoo, Mark W. Blyn, Lawrence B. Ecker, David J. Sampath, Rangarajan Whitehouse, Chris A. TI Rapid identification of vector-borne flaviviruses by mass spectrometry SO MOLECULAR AND CELLULAR PROBES LA English DT Article DE Ibis-T5000; Electrospray ionization; Tick-borne; Mosquito-borne; Arbovirus ID POLYMERASE CHAIN-REACTION; UNIVERSAL BIOSENSOR; POWASSAN VIRUS; AEDES-AEGYPTI; PCR ASSAY; RT-PCR; ENCEPHALITIS; MOSQUITOS; PRIMERS; RNA AB Flaviviruses are a highly diverse group of RNA viruses classified within the genus Flavivirus, family Flaviviridae. Most flaviviruses are arthropod-borne, requiring a mosquito or tick vector. Several flaviviruses are highly pathogenic to humans: however, their high genetic diversity and immunological relatedness makes them extremely challenging to diagnose. In this study, we developed and evaluated a broad-range Flavivirus assay designed to detect both tick- and mosquito-borne flaviviruses by using RT-PCR/electrospray ionization mass spectrometry (RT-PCR/ESI-MS) on the Ibis T5000 platform. The assay was evaluated with a panel of 13 different flaviviruses. All samples were correctly identified to the species level. To determine the limit of detection for the mosquito-borne primer sets, serial dilutions of RNA from West Nile virus (WNV) were assayed and could be detected down to an equivalent viral titer of 0.2 plaque-forming units/mL Analysis of flaviviruses in their natural biological background included testing Aedes aegypti mosquitoes that were laboratory-infected with dengue-1 virus. The assay accurately identified the virus within infected mosquitoes, and we determined the average viral genome per mosquito to be 2.0 x 10(6). Using human blood, serum, and urine spiked with WNV and mouse blood and brain tissues from Karshi virus-infected mice, we showed that these clinical matrices did not inhibit the detection of these viruses. Finally, we used the assay to test field-collected Ixodes scapularis ticks collected from sites in New York and Connecticut. We found 16/322 (5% infection rate) ticks positive for deer tick virus, a subtype of Powassan virus. In summary, we developed a single high-throughput Flavivirus assay that could detect multiple tick- and mosquito-borne flaviviruses and thus provides a new analytical tool for their medical diagnosis and epidemiological surveillance. Published by Elsevier Ltd. C1 [Grant-Klein, Rebecca J.; Baldwin, Carson D.; Turell, Michael J.; Rossi, Cynthia A.; Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Li, Feng; Lovari, Robert; Crowder, Chris D.; Matthews, Heather E.; Rounds, Megan A.; Eshoo, Mark W.; Blyn, Lawrence B.; Ecker, David J.; Sampath, Rangarajan] Ibis Biosci, Carlsbad, CA 92008 USA. RP Whitehouse, CA (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM chris.whitehouse@us.army.mil FU Defense Advanced Research Projects Agency (DARPA); Department of Homeland Security (DHS) [W81XWH-05-C-0116]; U.S. Defense Threat Reduction Agency (DTRA); USAM-RIID [114538]; National Institute of Allergy and Infectious Diseases [1R43AI077156-01]; National Institutes of Health, Department of Health and Human Services [HHSN266200400100C]; National Research Council FX The authors thank Dr. Stuart Nichol, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia for helpful discussions and for supplying tick-borne encephalitis virus isolates for initial testing of the assay. The authors acknowledge the Defense Advanced Research Projects Agency (DARPA), the Department of Homeland Security (DHS) contract number W81XWH-05-C-0116, the U.S. Defense Threat Reduction Agency (DTRA) (USAM-RIID Research Plan #114538) for financial support. Additionally, the assay development and testing has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN266200400100C. This research was performed while R.J.G.-K. held a National Research Council Research Associateship Award at USAMRIID. For the Flavivirus surveillance of field-collected ticks, we acknowledge the Lyme Disease Association, the Tami Fund, and the National Institutes of Health, National Institute of Allergy and Infectious Diseases grant #1R43AI077156-01 for financial support. NR 37 TC 25 Z9 26 U1 1 U2 16 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0890-8508 J9 MOL CELL PROBE JI Mol. Cell. Probes PD AUG PY 2010 VL 24 IS 4 BP 219 EP 228 DI 10.1016/j.mcp.2010.04.003 PG 10 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology GA 630CP UT WOS:000280249600007 PM 20412852 ER PT J AU Ramsey, JJ Pan, E Chung, PW Wang, ZMM AF Ramsey, J. J. Pan, Ernian Chung, Peter W. Wang, Zhiming M. TI Superlattice Growth via MBE and Green's Function Techniques SO NANOSCALE RESEARCH LETTERS LA English DT Article DE Quantum dots; Green's function; Surface diffusion; Anisotropy ID QUANTUM-DOT SUPERLATTICES; PIEZOELECTRIC FIELDS; SELF-ORGANIZATION; SURFACE; NANOSTRUCTURES; ANISOTROPY; MIGRATION; SI(001); FILMS AB A model has been developed to simulate the growth of arrays consisting of a substrate on which alternating layers of quantum dots (QDs) and spacer layers are epitaxially grown. The substrate and spacer layers are modeled as an anisotropic elastic half-space, and the QDs are modeled as point inclusions buried within the half-space. In this model, the strain at the free surface of this half-space due to the buried point QDs is calculated, and a scalar measure of the strain at the surface is subsequently determined. New point QDs are placed on the surface where the previously calculated scalar strain measure is a minimum. Following available DFT results, this scalar strain measure is a weighted average of the in-plane strains. This model is constructed under the assumption that diffusional anisotropy can be neglected, and thus, the results are more in agreement with results from experiments of growth of SiGe QDs than experiments involving QDs of (In,Ga)As. C1 [Ramsey, J. J.; Pan, Ernian] Univ Akron, Coll Engn, Akron, OH 44325 USA. [Chung, Peter W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wang, Zhiming M.] Univ Arkansas, Inst Nanoscale Sci & Engn, Fayetteville, AR 72701 USA. RP Ramsey, JJ (reprint author), Univ Akron, Coll Engn, 302 Buchtel Common, Akron, OH 44325 USA. EM jjramsey@zips.uakron.edu; pan2@uakron.edu; pchung@arl.army.mil; zmwang@uark.edu RI Wang, Zhiming/Q-1031-2015 FU National Natural Science Foundation of China [10772106]; Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO) [W911NF-06-2-0038]; ASEE/SMART Fellowship FX This work was partially supported by the National Natural Science Foundation of China No. 10772106 (E Pan), the Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO) under the grant W911NF-06-2-0038 (E. Pan, P. W. Chung, J. J. Ramsey), and the ASEE/SMART Fellowship program (J. J. Ramsey). We are also grateful to Ohio Supercomputer Center for providing us with the required computer resource units under grant # PBS0268-2. We thank the reviewers of this article as well, for their vital input. NR 27 TC 1 Z9 1 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1931-7573 J9 NANOSCALE RES LETT JI Nanoscale Res. Lett. PD AUG PY 2010 VL 5 IS 8 BP 1272 EP 1278 DI 10.1007/s11671-010-9636-8 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 621HW UT WOS:000279567800005 PM 20676205 ER PT J AU Musser, JE Przybycin, CG Russo, P AF Musser, John E. Przybycin, Christopher G. Russo, Paul TI Regression of metastatic seminoma in a patient referred for carcinoma of unknown primary origin SO NATURE REVIEWS UROLOGY LA English DT Article ID GERM-CELL TUMORS; II TESTICULAR SEMINOMA; STAGE-I; RANDOMIZED-TRIAL; PRIMARY SITE; CANCER; DIAGNOSIS; RADIOTHERAPY; CARBOPLATIN; CISPLATIN AB Background. A 63-year-old man presented to an emergency department with abdominal and back pain. A 5 x 3 x 2 cm para-aortic mass was found adjacent to the left kidney, but the location of the primary tumor could not be identified. He was referred to a tertiary center with a diagnosis of retroperitoneal carcinoma of unknown primary origin. Atrophy of the left testicle was noted. Review of the biopsy material obtained at the first presentation showed histology characteristic of seminoma, and imaging revealed the presence of small intratesticular lesions. Repeat CT showed complete resolution of the metastatic para-aortic mass. The patient underwent left orchiectomy and adjuvant radiation therapy, and showed no signs of disease 6 months later. Investigations. CT of the checst, abdomen and pelvis, measurement of serum tumor markers, upper gastrointestinal endoscopy, colonoscopy, PET-CT and percutaneous needle biopsy of the para-aortic mass at the first presentation; physical examination, review of biopsy specimen with immunohistochemical staining for tumor markers, testicular ultrasonography and repeat CT of the chest, abdomen and pelvis at the second presentation. Diagnosis. Metastatic seminoma with spontaneous regression of the metastatic lesion. Management. Radical orchiectomy and adjuvant radiation therapy. C1 [Russo, Paul] Mem Sloan Kettering Canc Ctr, Sidney Kimmel Ctr Prostate & Urol Canc, Dept Urol, New York, NY 10021 USA. [Musser, John E.] Tripler Army Med Ctr, Dept Urol, Honolulu, HI 96859 USA. [Przybycin, Christopher G.] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA. RP Russo, P (reprint author), Mem Sloan Kettering Canc Ctr, Sidney Kimmel Ctr Prostate & Urol Canc, Dept Urol, 353 E 68th St, New York, NY 10021 USA. EM russop@mskcc.org NR 29 TC 1 Z9 1 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1759-4812 J9 NAT REV UROL JI Nat. Rev. Urol. PD AUG PY 2010 VL 7 IS 8 BP 466 EP 470 DI 10.1038/nrurol.2010.99 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 636WA UT WOS:000280773100006 PM 20606623 ER PT J AU Henne, MB AF Henne, Melinda B. TI Robotically Assisted Hysterectomy in Patients With Large Uteri: Outcomes in Five Community Practices SO OBSTETRICS AND GYNECOLOGY LA English DT Letter ID LAPAROSCOPIC HYSTERECTOMY C1 Walter Reed Army Med Ctr, Dept Reprod Endocrinol & Infertil, Washington, DC 20307 USA. RP Henne, MB (reprint author), Walter Reed Army Med Ctr, Dept Reprod Endocrinol & Infertil, Washington, DC 20307 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD AUG PY 2010 VL 116 IS 2 BP 441 EP 442 DI 10.1097/AOG.0b013e3181eafa24 PN 1 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 629HI UT WOS:000280186300032 PM 20664411 ER PT J AU Irish, JL Resio, DT AF Irish, Jennifer L. Resio, Donald T. TI Reply to discussion of "A hydrodynamics-based surge scale for hurricanes" SO OCEAN ENGINEERING LA English DT Article DE Hurricanes; Surge; Flood warning; Hurricane evacuation; Tropical cyclones ID MODEL; WIND C1 [Irish, Jennifer L.] Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA. [Resio, Donald T.] USA, Ctr Res & Dev, Vicksburg, MS 39180 USA. RP Irish, JL (reprint author), Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA. EM jirish@civil.tamu.edu; donald.t.resio@usace.army.mil OI Irish, Jennifer/0000-0002-2429-5953 FU U.S. Army Engineer Research and Development Center; Texas General Land Office Coastal Management [08-009-000] FX The research discussed in this reply was funded by the U.S. Army Engineer Research and Development Center and in part by the Texas General Land Office Coastal Management Program through Grant no. 08-009-000. The use of trade names does not constitute an endorsement in the use of these products by the U.S. Government. NR 25 TC 3 Z9 3 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD AUG PY 2010 VL 37 IS 11-12 BP 1085 EP 1088 DI 10.1016/j.oceaneng.2010.04.002 PG 4 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 621KG UT WOS:000279575800013 ER PT J AU Coe, CD Bower, KS Brooks, DB Stutzman, RD Hammer, JB AF Coe, Charles D. Bower, Kraig S. Brooks, Dain B. Stutzman, Richard D. Hammer, Jenna Burka TI Effect of Blast Trauma and Corneal Foreign Bodies on Visual Performance SO OPTOMETRY AND VISION SCIENCE LA English DT Article DE ocular trauma; visual acuity; contrast sensitivity; night vision; military; wavefront ID OPERATION IRAQI FREEDOM; CONTRAST LETTER ACUITY; COMBAT OCULAR TRAUMA; WAVE-FRONT ANALYSIS; MULTIPLE-SCLEROSIS; EYE INJURIES; ENDURING FREEDOM; BRAIN-INJURY; ABERRATIONS; PERSPECTIVE AB Purpose. To evaluate the effect of non-penetrating corneal foreign bodies secondary to explosive blasts on the visual performance of soldiers. Methods. In a prospective, non-interventional study subjective visual performance and objective optical quality of 11 injured eyes with retained corneal foreign bodies were compared with that of 11 normal controls. Visual performance measures consisted of best spectacle-corrected high-contrast visual acuity (HCVA), low-contrast (5%) visual acuity (LCVA), and contrast sensitivity (CS). LCVA was evaluated in two luminance levels (photopic and mesopic) and two glare conditions (with and without glare). Acuity measurements were scored using logMAR notation. Objective optical quality was assessed comparing total root mean square wavefront error (WFE) and percent higher order aberrations. Modulation transfer functions calculated from the wavefront maps were used to predict the results of the psychophysical contrast testing. Results. HCVA of injured eyes (M = -0.03) did not differ significantly (t((20)) = 1.56, p = 0.13) when compared with controls (M = -0.09). However, visual performance of injured eyes (M = 0.33) was significantly worse than control eyes (M = 0.11) on photopic LCVA (t((20)) = 4.16, p < 0.001), mesopic LCVA(M = 0.44 vs. M = 0.21, t((20)) = 3.85, p = 0.001), mesopic LCVA with glare (M = 0.49 vs. M = 0.21, t((20)) = 3.66, p = 0.002), and small letter CS (M = 0.25 vs. M = 0.90, t((20)) = -6.6, p < 0.001). For a 6-mm pupil, mean absolute WFE attributed to higher order aberrations for the injured eyes was 0.86 mu m and 0.59 mu m for the control eyes. This difference was significant (t((20)) = -2.15, p = 0.044). Conclusions. Although HCVA was no different than the normal controls, visual performance of the injured eyes was significantly worse in terms of LCVA and CS. On average, visual performance can be broadly predicted by the modulation transfer function derived from the subjects' wavefront aberration map. (Optom Vis Sci 2010; 87: 604-611) C1 [Coe, Charles D.; Bower, Kraig S.; Stutzman, Richard D.] Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Washington, DC 20307 USA. [Brooks, Dain B.] Brooke Army Med Ctr, Ophthalmol Serv, San Antonio, TX USA. [Hammer, Jenna Burka] Bluegrass Eye, Louisville, KY USA. RP Coe, CD (reprint author), Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Room 2F-214,6900 Georgia Ave NW, Washington, DC 20307 USA. EM charles.coe@us.army.mil NR 42 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-5488 J9 OPTOMETRY VISION SCI JI Optom. Vis. Sci. PD AUG PY 2010 VL 87 IS 8 BP 604 EP 611 DI 10.1097/OPX.0b013e3181e61bc0 PG 8 WC Ophthalmology SC Ophthalmology GA 634AS UT WOS:000280551000012 PM 20512081 ER PT J AU Coster, T Fram, D Xie, S Friedl, K Cordts, P AF Coster, Trinka Fram, David Xie, Suji Friedl, Karl Cordts, Paul TI Development of an Automated Pharmacovigilance System within the Military Healthcare System SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY LA English DT Meeting Abstract C1 [Coster, Trinka; Xie, Suji] OTSG Army, Silver Spring, MD USA. [Fram, David] Phase Forward Inc, Waltham, MA USA. [Friedl, Karl] TATRC, Ft Detrick, MD USA. [Cordts, Paul] US Army Med Dept Act, Ft Stewart, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1053-8569 EI 1099-1557 J9 PHARMACOEPIDEM DR S JI Pharmacoepidemiol. Drug Saf. PD AUG PY 2010 VL 19 SU 1 MA 180 BP S77 EP S77 PG 1 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy GA V45OP UT WOS:000209826200175 ER PT J AU Anderson, J Massaro, R Lewis, L Moyers, R Wilkins, J AF Anderson, J. Massaro, R. Lewis, L. Moyers, R. Wilkins, J. TI Lidar-activated Phosphors and Infrared Retro-Reflectors: Emerging Target Materials for Calibration and Control SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Editorial Material C1 [Anderson, J.; Massaro, R.; Wilkins, J.] USA, Corps Engineers, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. [Lewis, L.; Moyers, R.] US DOE, Oak Ridge Natl Labs, Oak Ridge, TN 37830 USA. RP Anderson, J (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. EM john.anderson@usace.army.mil NR 12 TC 2 Z9 2 U1 1 U2 2 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD AUG PY 2010 VL 76 IS 8 BP 877 EP 881 PG 5 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA 632QD UT WOS:000280439800002 ER PT J AU Wellenius, P Smith, ER Wu, PC Everitt, HO Muth, JF AF Wellenius, Patrick Smith, Eric R. Wu, Pae C. Everitt, Henry O. Muth, John F. TI Effect of oxygen pressure on the structure and luminescence of Eu-doped Gd2O3 thin films SO PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE LA English DT Article DE gadolinium oxide; photoluminescence; pulsed laser deposition ID MONOCLINIC GD2O3; UP-CONVERSION; NANOCRYSTALS; EXCITATION; PHOSPHORS; MODEL AB Europium-doped gadolinium oxide (Gd2O3) thin films were deposited on sapphire substrates by pulsed laser deposition (PLD). The effect of oxygen pressure during deposition on the structure of the thin films, investigated by transmission electron microscopy (TEM) and X-ray diffraction (XRD), was correlated to photoluminescence spectra. The polycrystalline films, like the one deposited in 5 mTorr oxygen environment, were primarily monoclinic phase; however the rarer cubic phase was achieved at 50 mTorr pressure. Time-integrated and time-resolved photoluminescence (TIPL and TRPL) spectra of the bright D-5(0) to F-7(2) radiative transition revealed how the differing host material phases altered the local environment of the Eu dopants. (c) 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Wellenius, Patrick; Muth, John F.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. [Smith, Eric R.] Kratos Def & Secur Solut Inc, Huntsville, AL 35805 USA. [Wu, Pae C.; Everitt, Henry O.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. [Everitt, Henry O.] USA, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. RP Muth, JF (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. EM muth@ncsu.edu RI Everitt, Henry/L-7118-2013; Muth, John/E-9027-2012 OI Everitt, Henry/0000-0002-8141-3768; Muth, John/0000-0002-2488-7721 FU Army's competitive in-house laboratory independent research program; ONR Young Investigator Program; NSF [STTR IIP-0712295] FX This work was partially supported by the Army's competitive in-house laboratory independent research program, the ONR Young Investigator Program, and NSF STTR IIP-0712295. The authors would like to thank John V. Foreman and Henry H. Everitt for their assistance with the optical spectroscopy, as well as Protochips, Inc. (Raleigh, NC) for providing TEM substrates. NR 16 TC 0 Z9 0 U1 0 U2 16 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1862-6300 J9 PHYS STATUS SOLIDI A JI Phys. Status Solidi A-Appl. Mat. PD AUG PY 2010 VL 207 IS 8 BP 1949 EP 1953 DI 10.1002/pssa.201026071 PG 5 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 648KA UT WOS:000281691300030 ER PT J AU Potts, JA Gibbons, RV Rothman, AL Srikiatkhachorn, A Thomas, SJ Supradish, PO Lemon, SC Libraty, DH Green, S Kalayanarooj, S AF Potts, James A. Gibbons, Robert V. Rothman, Alan L. Srikiatkhachorn, Anon Thomas, Stephen J. Supradish, Pra-on Lemon, Stephenie C. Libraty, Daniel H. Green, Sharone Kalayanarooj, Siripen TI Prediction of Dengue Disease Severity among Pediatric Thai Patients Using Early Clinical Laboratory Indicators SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID ORGANIZATION CLASSIFICATION-SYSTEM; HEMORRHAGIC-FEVER; ECONOMIC-IMPACT; PUBLIC-HEALTH; FEATURES; CHILDREN; INFECTION; DIAGNOSIS; ILLNESS; PATHOGENESIS AB Background: Dengue virus is endemic in tropical and sub-tropical resource-poor countries. Dengue illness can range from a nonspecific febrile illness to a severe disease, Dengue Shock Syndrome (DSS), in which patients develop circulatory failure. Earlier diagnosis of severe dengue illnesses would have a substantial impact on the allocation of health resources in endemic countries. Methods and Findings: We compared clinical laboratory findings collected within 72 hours of fever onset from a prospective cohort children presenting to one of two hospitals (one urban and one rural) in Thailand. Classification and regression tree analysis was used to develop diagnostic algorithms using different categories of dengue disease severity to distinguish between patients at elevated risk of developing a severe dengue illness and those at low risk. A diagnostic algorithm using WBC count, percent monocytes, platelet count, and hematocrit achieved 97% sensitivity to identify patients who went on to develop DSS while correctly excluding 48% of non-severe cases. Addition of an indicator of severe plasma leakage to the WHO definition led to 99% sensitivity using WBC count, percent neutrophils, AST, platelet count, and age. Conclusions: This study identified two easily applicable diagnostic algorithms using early clinical indicators obtained within the first 72 hours of illness onset. The algorithms have high sensitivity to distinguish patients at elevated risk of developing severe dengue illness from patients at low risk, which included patients with mild dengue and other non-dengue febrile illnesses. Although these algorithms need to be validated in other populations, this study highlights the potential usefulness of specific clinical indicators early in illness. C1 [Potts, James A.; Rothman, Alan L.; Srikiatkhachorn, Anon; Libraty, Daniel H.; Green, Sharone] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01605 USA. [Gibbons, Robert V.; Thomas, Stephen J.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Supradish, Pra-on; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Lemon, Stephenie C.] Univ Massachusetts, Sch Med, Div Prevent & Behav Med, Worcester, MA USA. RP Potts, JA (reprint author), Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01605 USA. EM Sharone.Green@umassmed.edu FU National Institutes of Health [NIH-P01AI34533]; Centers for Disease Control and Prevention Office of the Director [1R36CK00123-01]; Military Infectious Disease Research Program FX This work was supported by National Institutes of Health Grant NIH-P01AI34533, Centers for Disease Control and Prevention Office of the Director Grant 1R36CK00123-01 (to J.A.P.), and the Military Infectious Disease Research Program. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the view of the U. S. Government. The funders had no role in the study design, data collection, analysis, decision to publish or preparation of the manuscript. NR 33 TC 36 Z9 39 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD AUG PY 2010 VL 4 IS 8 AR e769 DI 10.1371/journal.pntd.0000769 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 645HN UT WOS:000281443200003 PM 20689812 ER PT J AU Markicevic, B Nalla, A Navaz, HK Heider, D Walsh, S Advani, SG AF Markicevic, B. Nalla, A. Navaz, H. K. Heider, D. Walsh, S. Advani, S. G. TI Closed Form Solution of Resin Flow From Multiple Line Gates in Liquid Composite Molding SO POLYMER COMPOSITES LA English DT Article ID FIBROUS POROUS-MEDIA; EFFECTIVE VISCOSITY; BRINKMAN EQUATION; TRANSVERSE FLOW; INTERFACE; MODEL; WALL AB The resin flow from multiple line injection into a fibrous porous medium is investigated analytically and experimentally. The flow in a rectangular porous medium is created by placing two inlets: a channel along one of the domain edges, and a manifold placed in the center of the domain perpendicular to the first inlet on the top surface of the porous medium. It is demonstrated that two distinct sub-regions of the porous medium exist: inner sub-region which is filled by the liquid from the manifold, and outer sub-region that is filled by fluid from the channel. In the experiments, the following geometric parameters are varied: channel cross-sectional area, mold width, and thickness to investigate how the processing parameters influence which part of the overall domain is filled by fluid from a specific inlet. Neither fluid nor porous medium are varied throughout the study. For nonconstrained flow, an analytical model is formulated to predict the interface between the two sub-regions which is called the inner sub-region thickness. Both, implicit and explicit solutions are found, where the explicit solution is represented as inverse Lambert function. The solution relies on one physical constant which is a function of the pressure gradients and the directional permeabilities of the fibrous preform. Comparisons between experimental and analytical results reveal an excellent agreement for various sets of geometric parameters. This research should prove useful in understanding the flow in composites manufacturing when resin is injected simultaneously from multiple gates and channels. POLYM. COMPOS., 31:1434-1441, 2010. (C) 2009 Society of Plastics Engineers C1 [Nalla, A.; Heider, D.; Advani, S. G.] Univ Delaware, Ctr Composite Mat, Dept Mech Engn, Newark, DE 19716 USA. [Markicevic, B.; Navaz, H. K.] Kettering Univ, Dept Mech Engn, Flint, MI 48504 USA. [Walsh, S.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Advani, SG (reprint author), Univ Delaware, Ctr Composite Mat, Dept Mech Engn, Newark, DE 19716 USA. EM advani@udel.edu FU Army Research Laboratory [DAAD 19-01-2-005]; Office of Naval Research, Advanced Material Intelligent Processing Center (University of Delaware) [N000 14-06-1-1000] FX Contract grant sponsor: Army Research Laboratory; contract grant number: DAAD 19-01-2-005; contract grant sponsor: Office of Naval Research, Advanced Material Intelligent Processing Center (University of Delaware); contract grant number: N000 14-06-1-1000. NR 18 TC 3 Z9 3 U1 0 U2 3 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0272-8397 J9 POLYM COMPOSITE JI Polym. Compos. PD AUG PY 2010 VL 31 IS 8 BP 1434 EP 1441 DI 10.1002/pc.20929 PG 8 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA 631CI UT WOS:000280323800015 ER PT J AU Wang, GH Weng, YM Zhao, J Chu, D Xie, D Chen, RR AF Wang, Guigui Weng, Yiming Zhao, Jun Chu, Deryn Xie, Dong Chen, Rongrong TI Developing a novel alkaline anion exchange membrane derived from poly(ether-imide) for improved ionic conductivity SO POLYMERS FOR ADVANCED TECHNOLOGIES LA English DT Article DE poly(ether-imide); chloromethylation; quaternization; alkaline anion exchange membrane; ionic conductivity ID FUEL-CELLS AB We have developed a novel alkaline anion exchange membrane derived from poly(ether-imide) for improved ionic conductivity. The effects of several important parameters on the chloromethylation of the membrane were investigated. These parameters included reaction temperature, reaction time, concentration of chloromethylation agent, concentration of polymer, and the amount of catalyst. The quaternization of the synthesized chloromethylated polymer was studied as well. The results show that all the studied parameters exhibited significant impacts on chloromethylation. Among them, the concentration of the chloromethylation agent played a key role in increasing the chloromethyl functional group attachment onto the polymer. It was found that the gelation could be avoided if these reaction parameters were controlled. It was also found that using an appropriate quaternization approach could significantly improve the ionic conductivity and optimize the conductivity of the membrane even though the functional chloromethyl groups attached to the polymer are limited. Copyright (C) 2009 John Wiley & Sons, Ltd. C1 [Wang, Guigui; Weng, Yiming; Zhao, Jun; Xie, Dong; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, 799 W Michigan St,ET 209E, Indianapolis, IN 46202 USA. EM rochen@iupui.edu RI Zhao, Jun/E-7095-2012 FU Army Research Laboratory [W911NF-07-2-0036]; Richard G. Lugar Center for Renewable Energy at Indiana University-Purdue University Indianapolis FX Contract/grant sponsor: Army Research Laboratory; contract/grant number: W911NF-07-2-0036.; Contract/grant sponsor: Richard G. Lugar Center for Renewable Energy at Indiana University-Purdue University Indianapolis. NR 20 TC 37 Z9 37 U1 4 U2 27 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1042-7147 J9 POLYM ADVAN TECHNOL JI Polym. Adv. Technol. PD AUG PY 2010 VL 21 IS 8 BP 554 EP 560 DI 10.1002/pat.1463 PG 7 WC Polymer Science SC Polymer Science GA 635QB UT WOS:000280670100003 ER PT J AU Saxena, A Tipparaju, P Luo, C Doctor, BP AF Saxena, Ashima Tipparaju, Prasanthi Luo, Chunyuan Doctor, Bhupendra P. TI Pilot-scale production of human serum butyrylcholinesterase suitable for use as a bioscavenger against nerve agent toxicity SO PROCESS BIOCHEMISTRY LA English DT Article DE Human serum butyrylcholinesterase; Cohn fraction IV-4; Organophosphorus nerve agents; Bioscavenger; Pilot-scale production ID COCAINE TOXICITY; CHOLINESTERASE; PURIFICATION; MICE; PHARMACOKINETICS; STABILITY AB Human serum butyrylcholinesterase (Hu BChE) is currently the most appropriate candidate for the prophylaxis of humans against organophosphate (OP) nerve agent toxicity. It is estimated that a dose of 200 mg will protect a human against 2 x LD(50) of soman, which means that gram quantities of enzyme are needed for human clinical studies. Toward this effort, we report the development of the first procedure that is suitable for the pilot-scale purification of Hu BChE from Cohn fraction IV-4 paste. This procedure involved resuspension of Cohn fraction IV-4 paste, followed by procainamide affinity and DEAE anion-exchange chromatography. The procedure yielded 6-7 g (4.3-5 million U) of purified enzyme from 80 kg of Cohn fraction IV-4 paste. The enzyme was >97% pure as judged by a specific activity of similar to 700 U/mg and a major band with a subunit molecular weight of 85 kDa on SDS-PAGE. The high yield and purity obtained suggest that this manufacturing procedure is suitable for the pre-clinical production of Hu BChE. Published by Elsevier Ltd. C1 [Saxena, Ashima; Tipparaju, Prasanthi; Luo, Chunyuan] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ashima.saxena@us.army.mil NR 20 TC 17 Z9 17 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-5113 J9 PROCESS BIOCHEM JI Process Biochem. PD AUG PY 2010 VL 45 IS 8 BP 1313 EP 1318 DI 10.1016/j.procbio.2010.04.021 PG 6 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Engineering, Chemical SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Engineering GA 631XA UT WOS:000280382800014 ER PT J AU Ciezak, JA AF Ciezak, Jennifer A. TI The High-Pressure Characterization of Energetic Materials: 1-Methyl-5-Nitramino-1H-Tetrazole SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Diamond Anvil Cell; Energetic Material; High-Nitrogen Material; High-Pressure; 1-Methyl-5-Nitramino-1H-Tetrazole ID VIBRATIONAL SPECTROSCOPY AB Pressure volume relations and optical Raman and In spectra of polycrystalline 1MNT have been obtained under quasi-hydrostatic conditions up to 16 and 40 GPa. respectively. by using diamond anvil cell. synchrotron-based angle-resolved X-ray diffraction, and microspectroscopy The X-ray measurements show that the pressure volume relations remain smooth up to 16 GPa at room temperature. while vibrational measurements show no evidence of a phase transition to near 40 GPa Anomalous increases of several vibrational intensities and bandwidths suggest that subtle molecular distortions and structural modifications occur in the crystal as pressure increases Decompression experiments indicate the structural modifications are reversible C1 USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak, JA (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CHI0886] FX Thanks are due to Dr Jingzhu Hu and Dr Zhenxian Liu of BNL foi their technical assistance Use of the National Synchrotron Light Source. Brookhaven National Laboratory, was supported by the U S Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No DE-AC02-98CHI0886 Special thanks are due to the Geophysical Laboratory of the Carnegie Institution of Washington for use of their Raman systems and sample loading facilities NR 16 TC 8 Z9 8 U1 0 U2 16 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD AUG PY 2010 VL 35 IS 4 BP 373 EP 378 DI 10.1002/prep.200900077 PG 6 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 646LS UT WOS:000281542700010 ER PT J AU Bezmelnitsyn, A Thiruvengadathan, R Barizuddin, S Tappmeyer, D Apperson, S Gangopadhyay, K Gangopadhyay, S Redner, P Donadio, M Kapoor, D Nicolich, S AF Bezmelnitsyn, Andrey Thiruvengadathan, Rajagopalan Barizuddin, Syed Tappmeyer, Daniel Apperson, Steven Gangopadhyay, Keshab Gangopadhyay, Shubhra Redner, Paul Donadio, Mike Kapoor, Deepak Nicolich, Steven TI Modified Nanoenergetic Composites with Tunable Combustion Characteristics for Propellant Applications SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Combustion; Nanoenergetics Propellant; Reactivity; Thermites ID SOL-GEL SYNTHESIS; ALUMINUM NANOPARTICLES; IRON-OXIDE; REACTIVITY; BEHAVIOR; NANO AB This work reports on the synthesis and tunable characteristics of nanothermite compositions based on mesoporous Fe(2)O(3) as an oxidizer and Al nanoparticles as a fuel The reactivity (late of increase of pressure) and the combustion wave speed were determined to evaluate the performance of these composites for various applications A gas generating polymer. (acrylamidomethyl) cellulose acetate butyrate (AAMCAB), was loaded in the mesopores of Fe(2)O(3) matrix following wet-impregnation technique The samples prepared in this work were characterized by a number of analytical techniques such as Fourier transform infrared (FTIR) absorption spectroscopy, transmission and scanning electron microscopy (TEM. SEM). energy dispersive X-ray analysis, X-ray diffraction, and nitrogen adsorption-desorption isotherms Then. mesoporous Fe(2)O(3) powder was mixed with Al nanoparticles to prepare nanoenergetic composites The main characteristics such as peak pressure. reactivity. combustion wave speed, and pressure sustenance were determined as a function of polymer loading The dependence of combustion wave speed on the pressure was established following the well-known Vieille's law The small value of 0408 for the pressure exponent indicates the suitability of these nanothermite compositions for propellant applications By reducing the percentage of polymer. the characteristic properties of nanoenergetic composite can be suitably tuned for other applications C1 [Bezmelnitsyn, Andrey; Thiruvengadathan, Rajagopalan; Barizuddin, Syed; Tappmeyer, Daniel; Apperson, Steven; Gangopadhyay, Keshab; Gangopadhyay, Shubhra] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. [Redner, Paul; Donadio, Mike; Kapoor, Deepak; Nicolich, Steven] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Gangopadhyay, S (reprint author), Univ Missouri, Dept Elect & Comp Engn, 243 Engn Bldg W, Columbia, MO 65211 USA. OI Thiruvengadathan, Rajagopalan/0000-0001-9609-3245 FU US ARMY ARDEC; NSF [ECS-0619607, 9871184]; Research Board, University of Missouri [URB-04-020]; [PRM-06-029] FX We gratefully acknowledge the financial support by US ARMY ARDEC. NJ We thank Louis Ross from the electron microscopy core at our University for his assistance with the SEM images and EDS spectrum obtained using FEI Quanta FEG 600 acquired under NSF Award ECS-0619607 and through an award PRM-06-029 and other internal funds from the University of Missouri and Hitachi S-4700 acquired under NSF Award 9871184) and a Thermo Noran NSS-300 acquired under a Research Board Award URB-04-020 from the University of Missouri. respectively NR 23 TC 15 Z9 16 U1 1 U2 26 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD AUG PY 2010 VL 35 IS 4 BP 384 EP 394 DI 10.1002/prep.200800077 PG 11 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 646LS UT WOS:000281542700012 ER PT J AU Damavarapu, R Klapotke, TM Stierstorfer, J Tarantik, KR AF Damavarapu, Reddy Klapotke, Thomas M. Stierstorfer, Joerg Tarantik, Karina R. TI Barium Salts of Tetrazole Derivatives - Synthesis and Characterization SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Energetic Materials; Nitrogen-Rich Salts; Tetrazoles; X-Ray Diffractometry ID ENERGETIC MATERIALS; ALKALI SALTS; CRYSTAL; 5-AMINOTETRAZOLE; REFINEMENT AB The compounds barium tetrazolate (6). ban urn 5-ammotettazolate tetrahydiate (7). barium 5-nitriminotetrazolate dihydrate (8), barium bis(1H-5-nitriminotetrazolate) tetrahydrate (9). barium 1-methy1-5-mtrimmotetrazolate monohydrate (10). and barium 2-methyl-5-nitriminotetrazolate dihydrate (11) were synthesized by the reactions of barium hydroxide octahydrate and 1H-tetrazole (1). 5-aminotetrazole (2). 1.4H-5-nitriminotetrazole (3). 1-methyl-5-nitriminotetrazole (4), and 2-methyl-5-nitriminotetrazole (5). respectively The compounds were characterized using multi-nuclear NMR spectroscopy. vibrational (IR and Raman) spectroscopy. elemental analysis. and differential scanning calorimetry The solid-state structures of 7-11 weft. (determined using low temperature X-ray diffraction and a comprehensive characterization is given In addition, the sensitivities (impact. fiction. electrical discharge) of 6-11 were investigated and bomb calorimetric measurements were carried out. C1 [Klapotke, Thomas M.; Stierstorfer, Joerg; Tarantik, Karina R.] Univ Munich LMU, Dept Chem & Biochem, D-81377 Munich, Germany. [Damavarapu, Reddy] USA, ARDEC, Energet & Warheads Res & Dev Div, Picatinny Arsenal, NJ 07806 USA. RP Klapotke, TM (reprint author), Univ Munich LMU, Dept Chem & Biochem, Butenandtstr 5-13, D-81377 Munich, Germany. RI Stierstorfer, Joerg/B-5261-2015; Klapoetke, Thomas/B-6055-2014 OI Stierstorfer, Joerg/0000-0002-2105-1275; Klapoetke, Thomas/0000-0003-3276-1157 FU Ludwig-Maximilian University of Munich (LMU); Fonds der Chemischen Industrie (FCI); European Research Office (ERO) of the US Army Research Laboratory (ARL); Armament Research, Development and Engineering Center (ARDEC) [W911NF-09-2-0018, W911NF-09-1-0120, W011NF-09-1-0056] FX Financial support of this work by the Ludwig-Maximilian University of Munich (LMU). the Fonds der Chemischen Industrie (FCI). the European Research Office (ERO) of the US Army Research Laboratory (ARL). and the Armament Research, Development and Engineering Center (ARDEC) under contract nos W911NF-09-2-0018, W911NF-09-1-0120, and W011NF-09-1-0056 is gratefully acknowledged The authors acknowledge collaborations with Dr Mila Krupka (OZM Research, Czech Republic) in the development of new testing and evaluation methods for energetic materials and with Dr Muhamed Sucesca (Brodarski Institute. Croatia) in the development of new computational codes to predict the detonation and propulsion parameters of novel explosives We are indebted to and thank Dr Betsy M Rice and Dr Brad Foich (ARL. Aberdeen. Proving Ground, MD) and Dr Gary Chen (ARDEC. Picatinny Arsenal. NJ) for many helpful and inspired discussions and support of our work Furthermore, special thanks to Stefan Huber for determining the sensitivities and carrying out the calorimetric measurements NR 46 TC 23 Z9 23 U1 3 U2 22 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD AUG PY 2010 VL 35 IS 4 BP 395 EP 406 DI 10.1002/prep.200900058 PG 12 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 646LS UT WOS:000281542700013 ER PT J AU Ford, BQ Tamir, M Brunye, TT Shirer, WR Mahoney, CR Taylor, HA AF Ford, Brett Q. Tamir, Maya Brunye, Tad T. Shirer, William R. Mahoney, Caroline R. Taylor, Holly A. TI Keeping Your Eyes on the Prize: Anger and Visual Attention to Threats and Rewards SO PSYCHOLOGICAL SCIENCE LA English DT Article DE emotions; visual attention; motivation; rewards; threat ID SELECTIVE ATTENTION; TRAIT ANGER; ANXIETY; INFORMATION; EMOTION; AWARENESS; SYSTEMS; BIASES; ROLES; FACES AB People's emotional states influence what they focus their attention on in their environment. For example, fear focuses people's attention on threats, whereas excitement may focus their attention on rewards. This study examined the effect of anger on overt visual attention to threats and rewards. Anger is an unpleasant emotion associated with approach motivation. If the effect of emotion on visual attention depends on valence, we would expect anger to focus people's attention on threats. If, however, the effect of emotion on visual attention depends on motivation, we would expect anger to focus people's attention on rewards. Using an eye tracker, we examined the effects of anger, fear, excitement, and a neutral emotional state on participants' overt visual attention to threatening, rewarding, and control images. We found that anger increased visual attention to rewarding information, but not to threatening information. These findings demonstrate that anger increases attention to potential rewards and suggest that the effects of emotions on visual attention are motivationally driven. C1 [Ford, Brett Q.] Boston Coll, Dept Psychol, Chestnut Hill, MA 02467 USA. [Brunye, Tad T.; Shirer, William R.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Medford, MA 02155 USA. [Brunye, Tad T.; Shirer, William R.; Mahoney, Caroline R.] USA, NSRDEC, Natick, MA 01760 USA. RP Ford, BQ (reprint author), Boston Coll, Dept Psychol, 140 Commonwealth Ave, Chestnut Hill, MA 02467 USA. EM fordbc@bc.edu NR 40 TC 36 Z9 36 U1 7 U2 28 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0956-7976 J9 PSYCHOL SCI JI Psychol. Sci. PD AUG PY 2010 VL 21 IS 8 BP 1098 EP 1105 DI 10.1177/0956797610375450 PG 8 WC Psychology, Multidisciplinary SC Psychology GA 696PP UT WOS:000285454200010 PM 20581342 ER PT J AU Germain, JL AF Germain, Jesse L. TI Physical Program Leadership: From Kinesiology in the Classroom to Fitness Training in the Field SO QUEST LA English DT Article AB The complex and diverse mission of leading and administering the Physical Program and Kinesiology major at the United States Military Academy at West Point requires a broad and flexible application of leadership theory coupled with strict adherence to established and codified Army Values and Core Leader Competencies. This paper provides a closer look at the specific requirements and leadership challenges that the Kinesiology and Physical Education leaders at the Academy face each day, and provides the tools and strategies employed to meet those obligations. The discussion emphasizes employment of transformational, transactional, participatory, and situational leadership, and provides a continuum of leadership behaviors available to the Kinesiology leader ranging from authoritarian-centered to participatory-centered leadership. The paper affords all leaders in higher education an opportunity to reflect on their own leadership style, and offers ideas on modifying that leadership approach to more effectively administer their own program. C1 US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. RP Germain, JL (reprint author), US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. NR 10 TC 0 Z9 0 U1 0 U2 2 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 0033-6297 J9 QUEST JI Quest PD AUG PY 2010 VL 62 IS 3 BP 287 EP 295 PG 9 WC Education & Educational Research; Sport Sciences SC Education & Educational Research; Sport Sciences GA 633IH UT WOS:000280494700006 ER PT J AU Lim, CK AF Lim, Chai K. TI Eclipse Impact on a Remote Sensing Data Set: PAL NDVI 10-Day Composite from February 11 to 20 in 1999 for Western Australia SO REMOTE SENSING LA English DT Article DE NDVI; AVHRR; Eclipse; Western Australia; 10-day composite AB Pathfinder Normalized Difference Vegetation Index (NDVI) derived from Channel 1 (Red) and Channel 2 (near-infrared) of Advanced Very High Resolution Radiometer (AVHRR) onboard NOAA 14 became abnormally high for the 10-day composite from February 11 to 20 in 1999 for Western Australia. There was a solar eclipse in the satellite path on February 16 about the same time when NOAA 14 was above the eclipse location, causing the Channel 1 value to be 0 in many cells. The NDVI composite updating rule was to capture the greenest condition of each composite period. There seems to have been a possible lack of quality control during the NDVI composite generation, which could have caused the abnormally high NDVI values. However, there were some cells within the affected area that had values close to normal for NDVI as well as Channel 1 and Channel 2. The abnormal NDVI data values could have been avoided by not using the data obtained during the eclipse in the generation of the composite. Further investigation on those cells which were not affected by the eclipse is suggested for a better quality control of remote sensing data obtained during eclipse occurrences. C1 Walter Reed Army Inst Res, Dept Math & Biostat, Silver Spring, MD 20910 USA. RP Lim, CK (reprint author), Walter Reed Army Inst Res, Dept Math & Biostat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Chai.Lim@US.ARMY.MIL NR 13 TC 0 Z9 0 U1 0 U2 3 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-4292 J9 REMOTE SENS-BASEL JI Remote Sens. PD AUG PY 2010 VL 2 IS 8 BP 1962 EP 1972 DI 10.3390/rs2081962 PG 11 WC Remote Sensing SC Remote Sensing GA V24HP UT WOS:000208401800006 ER PT J AU Ward, KR Tiba, MH Ryan, KL Filho, IPT Rickards, CA Witten, T Sollerr, BR Ludwig, DA Convertino, VA AF Ward, Kevin R. Tiba, Mohamad H. Ryan, Kathy L. Filho, Ivo P. Torres Rickards, Caroline A. Witten, Tarryn Sollerr, Babs R. Ludwig, David A. Convertino, Victor A. TI Oxygen transport characterization of a human model of progressive hemorrhage SO RESUSCITATION LA English DT Article DE Hemorrhage; Lower body negative pressure; Trauma; Tissue oxygenation; Combat casualty; Monitoring ID BODY NEGATIVE-PRESSURE; CRITICAL O2 DELIVERY; CENTRAL HYPOVOLEMIA; RESUSCITATION RESEARCH; SCIENTIFIC PRIORITIES; SHOCK RESUSCITATION; SUPPLY DEPENDENCY; VOLUME; FLOW; INDICATOR AB Background: Hemorrhage continues to be a leading cause of death from trauma sustained both in combat and in the civilian setting. New models of hemorrhage may add value in both improving our understanding of the physiologic responses to severe bleeding and as platforms to develop and test new monitoring and therapeutic techniques. We examined changes in oxygen transport produced by central volume redistribution in humans using lower body negative pressure (LBNP) as a potential mimetic of hemorrhage. Methods and results: In 20 healthy volunteers, systemic oxygen delivery and oxygen consumption, skeletal muscle oxygenation and oral mucosa perfusion were measured over increasing levels of LBNP to the point of hemodynamic decompensation. With sequential reductions in central blood volume, progressive reductions in oxygen delivery and tissue oxygenation and perfusion parameters were noted, while no changes were observed in systemic oxygen uptake or markers of anaerobic metabolism in the blood (e.g., lactate, base excess). While blood pressure decreased and heart rate increased during LBNP, these changes occurred later than the reductions in tissue oxygenation and perfusion. Conclusions: These findings indicate that LBNP induces changes in oxygen transport consistent with the compensatory phase of hemorrhage, but that a frank state of shock (delivery-dependent oxygen consumption) does not occur. LBNP may therefore serve as a model to better understand a variety of compensatory physiological changes that occur during the pre-shock phase of hemorrhage in conscious humans. As such, LBNP may be a useful platform from which to develop and test new monitoring capabilities for identifying the need for intervention during the early phases of hemorrhage to prevent a patient's progression to overt shock. (C) 2010 Elsevier Ireland Ltd. All rights reserved. C1 [Ward, Kevin R.; Tiba, Mohamad H.; Filho, Ivo P. Torres; Witten, Tarryn] Virginia Commonwealth Univ, Dept Emergency Med, Richmond, VA 23298 USA. [Ward, Kevin R.; Tiba, Mohamad H.; Filho, Ivo P. Torres; Witten, Tarryn] Virginia Commonwealth Univ, Reanimat Engn Shock Ctr, Richmond, VA 23298 USA. [Ward, Kevin R.; Filho, Ivo P. Torres; Witten, Tarryn] Virginia Commonwealth Univ, Dept Physiol & Biophys, Richmond, VA 23298 USA. [Ward, Kevin R.; Witten, Tarryn] Virginia Commonwealth Univ, Ctr Study Biol Complex, Richmond, VA 23284 USA. [Ryan, Kathy L.; Rickards, Caroline A.; Convertino, Victor A.] USA, Inst Surg Res, Houston, TX 78234 USA. [Sollerr, Babs R.] Univ Massachusetts, Sch Med, Dept Anesthesiol, Worcester, MA 01655 USA. [Ludwig, David A.] Univ Miami, Miller Sch Med, Div Clin Res, Dept Pediat, Miami, FL 33101 USA. RP Ward, KR (reprint author), Virginia Commonwealth Univ, Dept Emergency Med, 1201 E Marshall St,POB 980401, Richmond, VA 23298 USA. EM krward@vcu.edu FU U.S. Army Medical Research and Material Command Combat Casualty Care [05-0033-02]; National Space Biomedical Research Institute under NASA [NCC 9-58] FX This work was funded by the U.S. Army Medical Research and Material Command Combat Casualty Care Research Program (Grant: 05-0033-02) and the National Space Biomedical Research Institute under NASA Cooperative Agreement NCC 9-58. NR 40 TC 32 Z9 32 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-9572 J9 RESUSCITATION JI Resuscitation PD AUG PY 2010 VL 81 IS 8 BP 987 EP 993 DI 10.1016/j.resuscitation.2010.03.027 PG 7 WC Critical Care Medicine; Emergency Medicine SC General & Internal Medicine; Emergency Medicine GA 639BU UT WOS:000280946600012 PM 20418009 ER PT J AU Guzman-Cornejo, C Robbins, RG AF Guzman-Cornejo, Carmen Robbins, Richard G. TI The genus Ixodes (Acari: Ixodidae) in Mexico: adult identification keys, diagnoses, hosts, and distribution SO REVISTA MEXICANA DE BIODIVERSIDAD LA English DT Article DE Ixodes; Ixodidae; keys; hosts; distribution; Mexico ID TICKS AB Identification keys, diagnoses, hosts, and distribution data are provided for adults of the 26 species of Ixodes known from Mexico. Data are from specimens deposited in the Coleccion Nacional de Acaros (CNAC), Instituto de Biologia, Universidad Nacional Autonoma de Mexico, and from the literature. C1 [Guzman-Cornejo, Carmen] Univ Nacl Autonoma Mexico, Fac Ciencias, Dept Biol Comparada, Lab Acarol, Mexico City 04510, DF, Mexico. [Robbins, Richard G.] Walter Reed Army Med Ctr, DPMIAC AFPMB, Washington, DC 20307 USA. RP Guzman-Cornejo, C (reprint author), Univ Nacl Autonoma Mexico, Fac Ciencias, Dept Biol Comparada, Lab Acarol, Mexico City 04510, DF, Mexico. EM mcgc@fciencias.unam.mx FU Direccion General de Asuntos del Personal Academico (DGAPA), Universidad Nacional Autonoma de Mexico FX The senior author thanks the Direccion General de Asuntos del Personal Academico (DGAPA), Universidad Nacional Autonoma de Mexico, for the award of a postdoctoral scholarship under the Programa de Formacion e Incorporacion de Profesores de Carrera en Facultades y Escuelas para el Fortalecimiento de la Investigacion (PROFIP). Tila Maria Perez, Curator of CNAC, generously granted access to specimens and literature. Thanks also to Griselda Montiel-Parra for her assistance in preparing the Ixodes distribution map. NR 20 TC 14 Z9 17 U1 0 U2 10 PU INST BIOLOGIA, UNIV NACIONAL AUTONOMA MEXICO PI MEXICO PA APARTADO POSTAL 70-233, MEXICO, D F 00000, MEXICO SN 1870-3453 J9 REV MEX BIODIVERS JI Rev. Mex. Biodivers. PD AUG PY 2010 VL 81 IS 2 BP 289 EP 298 PG 10 WC Biodiversity Conservation SC Biodiversity & Conservation GA 645FT UT WOS:000281437500006 ER PT J AU Kotru, S Highsmith, A Zhong, JA Rincon, V Jackson, JE Ashley, P AF Kotru, Sushma Highsmith, Alton Zhong, Jian Rincon, Veronica Jackson, John E. Ashley, Paul TI Feasibility study of a micromachined single-axis vibratory gyroscope using piezoelectric PNZT thin films for actuation and sensing SO SMART MATERIALS & STRUCTURES LA English DT Article ID MEMS GYROSCOPE; ATMOSPHERIC-PRESSURE AB Vibratory gyroscopes measure the angular velocity of a system by making use of the Coriolis effect. We have proposed a new design using double-sided piezoelectric Nb-doped Pb(Zr(20), Ti(80))O(3) films for actuation as well as sensing of a rate gyroscope. This design has the potential to increase the resolution of the device by increasing the mass of the gyro, that is, produce a meso-scale gyro using MEMS technology. Further, it could increase output signal amplitude by generating a higher Coriolis force, since PNZT films exhibit higher values of the effective transverse and longitudinal piezoelectric coefficients than some other piezoelectric materials. A three-dimensional finite element code, 'BAMAFEM', for dynamic analysis of gyroscopes was developed in-house. Validity of the new design was confirmed by simulations. The resonance frequency of the gyroscope was measured to be 12.60 kHz, which matches very well with the simulated results. In this paper are described the design and simulation of the gyroscope, the fabrication process, and testing of the device. C1 [Kotru, Sushma; Zhong, Jian; Rincon, Veronica] Univ Alabama, Dept Elect & Comp Engn, Tuscaloosa, AL 35487 USA. [Highsmith, Alton] Univ Alabama, Cent Analyt Facil, Tuscaloosa, AL 35487 USA. [Jackson, John E.] Univ Alabama, Dept Aerosp Engn & Mech, Tuscaloosa, AL 35487 USA. [Ashley, Paul] USA, Res Dev & Engn Command, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA. RP Kotru, S (reprint author), Univ Alabama, Dept Elect & Comp Engn, Tuscaloosa, AL 35487 USA. EM skotru@eng.ua.edu FU Federal Aviation Administration (FAA) [99-G-015]; University of Alabama; College of Engineering, UA FX The authors thank the Federal Aviation Administration (FAA) for funding the project (contract no. 99-G-015), University of Alabama for an internal grant 'RAC' and College of Engineering, UA for the startup funds. This work used the Central Analytical Facility, which is supported by the University of Alabama. The authors also extend their thanks to Ivy Robeson Mill and Gerry Tuck of the Aegis Technologies group and Eric Webster and Bill Diffey of US Army Aviation and Missile Command, Redstone Arsenal, Huntsville for their help during the course of this work. NR 41 TC 4 Z9 5 U1 2 U2 17 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 J9 SMART MATER STRUCT JI Smart Mater. Struct. PD AUG PY 2010 VL 19 IS 8 AR 085001 DI 10.1088/0964-1726/19/8/085001 PG 11 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA 626VM UT WOS:000279995500001 ER PT J AU Rosenblad, BL Bailey, J Csontos, R Van Arsdale, R AF Rosenblad, Brent L. Bailey, Jonathan Csontos, Ryan Van Arsdale, Roy TI Shear wave velocities of Mississippi embayment soils from low frequency surface wave measurements SO SOIL DYNAMICS AND EARTHQUAKE ENGINEERING LA English DT Article DE Surface waves; Site response; Shear wave velocity; New Madrid seismic zone; Dynamic soil properties; SASW ID TENNESSEE; MEMPHIS AB Deep unconsolidated sediments in the Mississippi embayment will influence ground motions from earthquakes in the New Madrid seismic zone. Shear wave velocity profiles of these sediments are important input parameters for modeling wave propagation and site response in this region. Low-frequency, active-source surface wave velocity measurements were performed to develop small-strain shear wave velocity (V(S)) profiles at eleven deep soil sites in the Mississippi embayment, from north of New Madrid, Missouri to Memphis, Tennessee. A servo-hydraulic, low-frequency source was used to excite surface wave energy to wavelengths of 600 m, resulting in V(S) profiles to depths of over 200 m. The average V(S) profile calculated from the eleven sites is in good agreement with common reference V(S) profiles that have been used in seismic hazard studies of this region. The variability in V(S) profiles is shown to be associated with changes in formation depth and thickness from site-to-site. Using lithologic information at each site, average formation velocities were developed and compared to previous studies. We found average V(S) values of about 193 m/s for alluvial deposits, 400 m/s for the Upper Claiborne formations, and 685 m/s for the Memphis Sand formation. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Rosenblad, Brent L.] Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. [Bailey, Jonathan] USA, Corps Engineers, St Louis, MO 63103 USA. [Csontos, Ryan] Univ Memphis, Ground Water Inst, Memphis, TN 38152 USA. [Van Arsdale, Roy] Univ Memphis, Dept Earth Sci, Memphis, TN 38152 USA. RP Rosenblad, BL (reprint author), Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. EM rosenbladb@missouri.edu FU United States Geological Survey [06-HQGRO050]; National Science Foundation [0530140] FX The authors thank the land owners for allowing access to the field sites, personnel from CERI for assistance in locating acceptable sites, and personnel from the NEES site at the University of Texas at Austin for assistance in the field. This work was supported by the United States Geological Survey (NEHRP award No. 06-HQGRO050) and the National Science Foundation Network for Earthquake Engineering Simulation program (Grant no. 0530140). NR 32 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0267-7261 J9 SOIL DYN EARTHQ ENG JI Soil Dyn. Earthq. Eng. PD AUG PY 2010 VL 30 IS 8 BP 691 EP 701 DI 10.1016/j.soildyn.2010.02.010 PG 11 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 603KE UT WOS:000278206700005 ER PT J AU Santen, SA Holt, DB Kemp, JD Hemphill, RR AF Santen, Sally A. Holt, Danielle B. Kemp, Jean D. Hemphill, Robin R. TI Burnout in Medical Students: Examining the Prevalence and Associated Factors SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE burnout; medical students; resiliency; stress ID PHYSICIAN BURNOUT; RESIDENCY PROGRAM; PATIENT-CARE; MULTICENTER; DISTRESS; EMPATHY AB Objective: Burnout has been described as a syndrome of emotional exhaustion, depersonalization, and decreased personal accomplishment, and may originate during medical school. The objective of this study is to determine the prevalence of burnout and contributing factors in medical students. Methods: A survey was administered to 249 medical students using a modified Maslach Burnout Inventory Human Services Survey (MBI-HSS) and scales of stressors, assessment of workload, relaxation, control, accomplishment, support systems, and demographics. Results: Moderate or high degree of burnout was seen in 21% of the first year class, 41% of the second year class, 43% of the third year class, and 31% of the fourth year class (P < 0.05). Lower support, higher stress, and lack of control over one's life were significantly related to burnout using multivariate analysis. Conclusions: Burnout progressively develops over the course of medical education, while a high level of support and low stress decreased burnout. C1 Emory Sch Med, Atlanta, GA USA. Vanderbilt Univ Sch Med, Nashville, TN USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. Natl Naval Med Ctr, Dept Pathol, Bethesda, MD USA. RP Santen, SA (reprint author), Emory Univ, Sch Med, 1648 Pierce Dr,Suite 453,MS-1020-004-1AJ, Atlanta, GA 30322 USA. EM ssanten@emory.edu NR 23 TC 35 Z9 39 U1 4 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD AUG PY 2010 VL 103 IS 8 BP 758 EP 763 DI 10.1097/SMJ.0b013e3181e6d6d4 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 703FU UT WOS:000285964600008 PM 20622724 ER PT J AU Kapoor, SG Huff, J Cohen, SP AF Kapoor, Shruti Gupta Huff, Jeremy Cohen, Steven P. TI Systematic review of the incidence of discitis after cervical discography SO SPINE JOURNAL LA English DT Review DE Discography; Cervical discography; Cervical discs; Discitis; Neck pain; Meta-analysis ID 2000-2010 TASK-FORCE; NECK PAIN; GENERAL-POPULATION; LUMBAR DISCOGRAPHY; PROPHYLACTIC ANTIBIOTICS; PROVOCATIVE DISCOGRAPHY; ASYMPTOMATIC SUBJECTS; INTERVERTEBRAL-DISK; SURGICAL INTERVENTIONS; PROGNOSTIC-FACTORS AB BACKGROUND CONTEXT: Cervical discography is not uniformly used in part because of the fear of discitis. Studies report widely varying rates of this life-threatening infection. PURPOSE: The aim of this study was to estimate the incidence of discitis after cervical discography, delineate the consequences of discitis, and identify factors that may influence this complication. STUDY DESIGN: Meta-analysis. METHODS: Studies pertaining to cervical discography were identified by a literature review and bibliographic search. These were screened for inclusion into the meta-analysis by two reviewers. Data were collected on a wide range of clinical and demographic variables including age, gender, morbidities, number of patients, number of discograms, use of prophylactic antibiotics, type of surgical prep, number of needles used, and the number of patients and discs infected. Primary data were used to calculate the incidence of discitis per patient and per disc. RESULTS: Fourteen studies were included in the analysis. Both procedural details and demographic information on patients were missing from eight studies. The mean age of patients ranged from 41 to 47 years, and gender distribution varied greatly. Antibiotics use was reported in three studies. Cervical discography was complicated by postprocedural discitis in 22 of 14,133 disc injections (0.15%) and 21 of 4,804 patients (0.44%). Only one patient suffered from an infection at more than one spinal level. CONCLUSIONS: The rate of discitis after cervical discography is relatively low. This can perhaps be further decreased by the use of prophylactic intradiscal antibiotics. Should the ability of cervical discography to improve surgical outcomes be proven, the fear of discitis should not preclude performance of disc provocation. Published by Elsevier Inc. C1 [Kapoor, Shruti Gupta; Huff, Jeremy] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Pain Div, Washington, DC 20307 USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu FU John P. Murtha Neuroscience and Pain Institute, Johnstown, PA; Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC FX This work is funded in part by a Congressional grant from the John P. Murtha Neuroscience and Pain Institute, Johnstown, PA, and the Army Regional Anesthesia & Pain Medicine Initiative, Washington, DC. NR 79 TC 7 Z9 9 U1 2 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD AUG PY 2010 VL 10 IS 8 BP 739 EP 745 DI 10.1016/j.spinee.2009.12.022 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 636QJ UT WOS:000280753300014 PM 20171935 ER PT J AU Johnson, DR Ang, C Bednar, AJ Inouye, LS AF Johnson, David R. Ang, ChooYaw Bednar, Anthony J. Inouye, Laura S. TI Tungsten Effects on Phosphate-Dependent Biochemical Pathways are Species and Liver Cell Line Dependent SO TOXICOLOGICAL SCIENCES LA English DT Article DE tungsten; phosphate; ATP; tyrosine kinase; cAMP; liver cell lines ID PROTEIN-TYROSINE PHOSPHATASES; INDUCED DIABETIC-RATS; SODIUM TUNGSTATE; HEPATOCELLULAR-CARCINOMA; BIOLOGICAL FUNCTION; ANTIDIABETIC AGENT; SULFITE OXIDASE; MOLECULAR-BASIS; MOLYBDENUM; NEVADA AB Tungsten, in the form of tungstate, polymerizes with phosphate, and as extensive polymerization occurs, cellular phosphorylation and dephosphorylation reactions may be disrupted, resulting in negative effects on cellular functions. A series of studies were conducted to evaluate the effect of tungsten on several phosphate-dependent intracellular functions, including energy cycling (ATP), regulation of enzyme activity (cytosolic protein tyrosine kinase [cytPTK] and tyrosine phosphatase), and intracellular secondary messengers (cyclic adenosine monophosphate [cAMP]). Rat noncancerous hepatocyte (Clone-9), rat cancerous hepatocyte (H4IIE), and human cancerous hepatocyte (HepG2) cells were exposed to 1-1000 mg/l tungsten (in the form of sodium tungstate) for 24 h, lysed, and analyzed for the above biochemical parameters. Cellular ATP levels were not significantly affected in any cell line. After 4 h, tungsten significantly decreased cytPTK activity in Clone-9 cells at >= 18 mg/l, had no effect in H4IIE cells, and significantly increased cytPTK activity by 70% in HepG2 cells at >= 2 mg/l. CytPTK displayed a slight hormetic response to tungsten after 24-h exposure yet returned to normal after 48-h exposure. Tungsten significantly increased cAMP by over 60% in Clone-9 cells at >= 100 mg/l, significantly increased cAMP in H4IIE cells at only 100 mg/l, and significantly increased cAMP in HepG2 cells between 1-100 mg/l but at much more modest levels (8-20%). In conclusion, these data indicate that tungsten produces complex results that must be carefully interpreted in the context of their respective animal models, as well as the phenotype of the cell lines (i.e., normal vs. cancerous). C1 [Johnson, David R.; Bednar, Anthony J.; Inouye, Laura S.] USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ang, ChooYaw] SpecPro Inc, Vicksburg, MS 39180 USA. RP Johnson, DR (reprint author), USA, Environm Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd,Bldg 6011, Vicksburg, MS 39180 USA. EM johnson@usace.army.mil FU United States Army Engineer Research and Development Center FX Environmental Quality Technology Program of the United States Army Engineer Research and Development Center. NR 51 TC 11 Z9 12 U1 2 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 J9 TOXICOL SCI JI Toxicol. Sci. PD AUG PY 2010 VL 116 IS 2 BP 523 EP 532 DI 10.1093/toxsci/kfq124 PG 10 WC Toxicology SC Toxicology GA 630ZL UT WOS:000280315800016 PM 20421338 ER PT J AU Krakauer, T AF Krakauer, Teresa TI Therapeutic Down-Modulators of Staphylococcal Superantigen-Induced Inflammation and Toxic Shock SO TOXINS LA English DT Review DE staphylococcal superantigens; therapeutics; inflammatory mediators; toxic shock; murine models AB Staphylococcal enterotoxin B (SEB) and related superantigenic toxins are potent stimulators of the immune system and cause a variety of diseases in humans, ranging from food poisoning to toxic shock. These toxins bind directly to major histocompatibility complex (MHC) class II molecules on antigen-presenting cells and specific V beta regions of T-cell receptors (TCR), resulting in hyperactivation of both monocytes/macrophages and T lymphocytes. Activated host cells produce massive amounts of proinflammatory cytokines and chemokines, activating inflammation and coagulation, causing clinical symptoms that include fever, hypotension, and shock. This review summarizes the in vitro and in vivo effects of staphylococcal superantigens, the role of pivotal mediators induced by these toxins in the pathogenic mechanisms of tissue injury, and the therapeutic agents to mitigate the toxic effects of superantigens. C1 USA, Dept Immunol, Integrated Toxicol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Krakauer, T (reprint author), USA, Dept Immunol, Integrated Toxicol Div, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM Teresa.krakauer@amedd.army.mil FU Defense Threat Reduction Agency FX I thank the Defense Threat Reduction Agency for generous financial support. NR 129 TC 13 Z9 13 U1 0 U2 2 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD AUG PY 2010 VL 2 IS 8 BP 1963 EP 1983 DI 10.3390/toxins2081963 PG 21 WC Toxicology SC Toxicology GA V24UN UT WOS:000208435400003 PM 22069668 ER PT J AU Myint, KSA Murray, CK Scott, RM Shrestha, MP Mammen, MP Shrestha, SK Kuschner, RA Joshi, DM Gibbons, RV AF Myint, Khin Saw Aye Murray, Clinton K. Scott, Robert McNair Shrestha, Mrigendra P. Mammen, Mammen P., Jr. Shrestha, Sanjaya K. Kuschner, Robert A. Joshi, Durga M. Gibbons, Robert V. TI Incidence of leptospirosis in a select population in Nepal SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE Nepal; Leptospirosis; ELISA; MAT; hepatitis E; serovar ID HEPATITIS-E VIRUS; ACUTE FEBRILE ILLNESS; IMMUNOGLOBULIN; KATHMANDU; EFFICACY; MONKEYS; ADULTS AB The geographic distribution of leptospirosis is widespread but no national surveillance program exists in Nepal to establish the incidence of leptospirosis or the disease burden. This study reports the incidence of symptomatic leptospirosis in military personnel participating ill an efficacy study of a hepatitis E virus vaccine in Nepal. Among the 1566 study volunteers who completed follow-up, we evaluated 271 illnesses over 2.2 years for the presence of leptospira IgM antibodies by ELISA. Positive ELISA results were confirmed by the microscopic agglutination test. The annual incidence of disease was between 3.5 and 6.1 cases/1000. The prevalence of confirmed leptospirosis was 9% among hepatitis cases and 8% among febrile cases. The most reactive serovars were Bratislava, Autumnalis, Icterohaemorrhagiae, and Sejroe. Leptospirosis should be considered in the differential diagnosis of febrile illnesses and icteric syndromes in Nepal. Additional studies are needed to establish the broader distribution and the spectrum of disease in Nepal. Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene. C1 [Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Myint, Khin Saw Aye; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Scott, Robert McNair; Shrestha, Mrigendra P.; Mammen, Mammen P., Jr.; Shrestha, Sanjaya K.] Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal. [Kuschner, Robert A.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Joshi, Durga M.] Shree Birendra Hosp, Kathmandu, Nepal. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil RI Valle, Ruben/A-7512-2013 FU Nepal Health Research Council; U.S. Army Medical Research and Materiel Command; GlaxoSmithKline Biologicals; GlaxoSmithKline FX The authors gratefully acknowledge the laboratory assistance of Kittinun Hussem of AFRIMS and Michael Gray of VETCOM. We thank the Nepal Health Research Council for their support of this clinical study.; Supported by the U.S. Army Medical Research and Materiel Command and GlaxoSmithKline Biologicals.; MPS, RMS, MPM, KSAM, RAK, SKS report being current or former employees or contractors of the U.S. Army and receiving funding through a cooperative research and development agreement with GlaxoSmithKline to conduct studies on HEV for 5 years or more before this clinical trial. NR 31 TC 1 Z9 1 U1 0 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD AUG PY 2010 VL 104 IS 8 BP 551 EP 555 DI 10.1016/j.trstmh.2010.04.001 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 639DX UT WOS:000280952100008 PM 20494385 ER PT J AU Mies, C AF Mies, C. TI The Breast Cancer Pathology Report in 2010 SO VIRCHOWS ARCHIV LA English DT Meeting Abstract C1 [Mies, C.] USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0945-6317 J9 VIRCHOWS ARCH JI Virchows Arch. PD AUG PY 2010 VL 457 IS 2 BP 111 EP 112 PG 2 WC Pathology SC Pathology GA 635GD UT WOS:000280642700051 ER PT J AU Zhao, R Chinnawirotpisan, P Klungthong, C Zhang, CL Putnak, R AF Zhao, Richard Chinnawirotpisan, Piyawan Klungthong, Chonticha Zhang, Chunlin Putnak, Robert TI Evidence for inter- and intra-genotypic variations in dengue serotype 4 viruses representing predominant and non-predominant genotypes co-circulating in Thailand from 1977 to 2001 SO VIRUS GENES LA English DT Article DE Dengue type-4 virus; Sequence analysis; Genetic variation ID SECONDARY STRUCTURE; VIRAL REPLICATION; FLAVIVIRUS RNA; NONSTRUCTURAL PROTEINS; CYCLIZATION SEQUENCES; MOLECULAR EVOLUTION; HEMORRHAGIC-FEVER; GENUS FLAVIVIRUS; STRANDED RNA; TRANSLATION AB In order to characterize viral genetic variation among predominant and non-predominant genotypes of Thai dengue serotype 4 viruses (DENV-4) and follow mutations that occur during virus evolution, we performed a comparative analysis of the complete genomic sequences of six DENV-4 isolates representing three genotypes (I, IIA, and III) co-circulating in Thailand over a 24-year period. The results revealed [1] remarkable genetic variation in the viral genome between predominant and non-predominant genotypes; [2] inter-genotype-specific amino acid and nucleotide mutations in most regions of the viral genome; [3] more amino acid and nucleotide substitutions in later as compared to earlier isolates for predominant genotype I strains; [4] a single nucleotide substitution at nucleotide position 77 of the 5-'NTR of two non-predominant genotype III strains that disrupted a small conserved 3'stem-loop (SL) in the cyclization sequence required for virus replication; [5] a high degree of conservation of PrM/M and NS2B proteins, and the 5'-NTR in predominant genotype I strains with no mutations observed over the 24-year period of observation; and [6] no molecular markers that appeared to correlate with disease severity. Several mutations identified in this study might have a significant impact on the persistence of virus in the population, including one in the 5'-NTR that disrupted a small, highly conserved 3'SL2 structure at the terminus of the cyclized 5'aEuro"3' RNA sequences in two genotype III strains, and three amino acid (aa) charge change mutations in the E and NS5 proteins of genotype I strains. The conserved 3'-SL structure may be a target for antiviral drug development. C1 [Zhang, Chunlin; Putnak, Robert] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Zhao, Richard] Walter Reed Army Inst Res, Sci & Engn Apprentice Program, Silver Spring, MD 20910 USA. [Chinnawirotpisan, Piyawan; Klungthong, Chonticha] US Army Med Component Armed Forces Res Inst Med S, Dept Virol, Bangkok, Thailand. RP Putnak, R (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM robert.putnak@amedd.army.mil FU George Washington University/Walter Reed Army Institute of Research; Fort Detrick, Maryland, USA FX We thank our field unit, Department of Virology, Armed Force Research Institute of Medical Sciences (AFRIMS) Bangkok, Thailand for sample characterization, sequencing, and storage; we thank the doctors and nurses of QSNICH/AFRIMS for sample collection and clinical grading. This research was supported by the Science and Engineering Apprentice Program (House support) sponsored by George Washington University/Walter Reed Army Institute of Research, and the US Military Infectious Disease Research Program at Fort Detrick, Maryland, USA. NR 46 TC 5 Z9 5 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-8569 J9 VIRUS GENES JI Virus Genes PD AUG PY 2010 VL 41 IS 1 BP 5 EP 13 DI 10.1007/s11262-010-0473-8 PG 9 WC Genetics & Heredity; Virology SC Genetics & Heredity; Virology GA 612LL UT WOS:000278899800002 PM 20336481 ER PT J AU Alam, A Kraczek, B Johnson, DD AF Alam, Aftab Kraczek, Brent Johnson, D. D. TI Structural, magnetic, and defect properties of Co-Pt-type magnetic-storage alloys: Density-functional theory study of thermal processing effects SO PHYSICAL REVIEW B LA English DT Article ID RANDOM SUBSTITUTIONAL ALLOYS; TOTAL-ENERGY CALCULATIONS; SCREENED REAL-SPACE; WAVE BASIS-SET; THIN-FILMS; ELECTRONIC-STRUCTURE; CURIE-TEMPERATURE; PHASE-TRANSFORMATION; FE-PT; NANOPARTICLES AB Using an optimized-basis Korringa-Kohn-Rostoker-coherent-potential approximation method, we calculate formation enthalpies Delta E(f), structural, and magnetic properties of paramagnetic (PM) and ferromagnetic, disordered A1 and ordered L1(0) CoPt, FePd, and FePt systems that are of interest for high-density magnetic-recording media. To address processing effects, we focus on the point defects that dictate thermal properties and planar defects (e.g., c domain and antiphase boundaries) which can serve as pinning centers for magnetic domains and affect storage properties. We determine bulk Curie (T(c)) and order-disorder (T(o-d)) transition temperatures within 4% of observed values, and estimates for nanoparticles. Planar-defect energies gamma(hkl)(x) show that the favorable [hkl] defects depend on processing conditions as T(c) < T(o-d) in these alloys, and the PM defects agree with those observed. We correlate all properties with the electronic structure. C1 [Alam, Aftab; Johnson, D. D.] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA. [Kraczek, Brent; Johnson, D. D.] Univ Illinois, Dept Phys, Urbana, IL 61801 USA. [Kraczek, Brent] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Alam, A (reprint author), Univ Illinois, Dept Mat Sci & Engn, 1304 W Green St, Urbana, IL 61801 USA. EM duanej@illinois.edu OI Johnson, Duane/0000-0003-0794-7283 FU Department of Energy [DEFG02-03ER46026]; Lawrence Livermore National Laboratory [B573247]; National Science Foundation [DMR-0705089] FX We are supported by the Department of Energy (Grant No. DEFG02-03ER46026) and Lawrence Livermore National Laboratory (Contract No. B573247). Ruoshi Sun performed some verification and test calculations for Summer REU project (National Science Foundation under Grant No. DMR-0705089) NR 116 TC 31 Z9 31 U1 3 U2 24 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD JUL 30 PY 2010 VL 82 IS 2 AR 024435 DI 10.1103/PhysRevB.82.024435 PG 16 WC Physics, Condensed Matter SC Physics GA 633BP UT WOS:000280474800006 ER PT J AU Ronning, CM Losada, L Brinkac, L Inman, J Ulrich, RL Schell, M Nierman, WC DeShazer, D AF Ronning, Catherine M. Losada, Liliana Brinkac, Lauren Inman, Jason Ulrich, Ricky L. Schell, Mark Nierman, William C. DeShazer, David TI Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elements SO BMC MICROBIOLOGY LA English DT Article ID SUBTRACTIVE HYBRIDIZATION; CEPACIA COMPLEX; GENOME SEQUENCE; CAUSATIVE AGENT; PSEUDOMALLEI; EVOLUTION; MALLEI; BACTERIOPHAGES; THAILANDENSIS; PATHOGENESIS AB Background: Burkholderia species exhibit enormous phenotypic diversity, ranging from the nonpathogenic, soil- and water-inhabiting Burkholderia thailandensis to the virulent, host-adapted mammalian pathogen B. mallei. Genomic diversity is evident within Burkholderia species as well. Individual isolates of Burkholderia pseudomallei and B. thailandensis, for example, carry a variety of strain-specific genomic islands (GIs), including putative pathogenicity and metabolic islands, prophage-like islands, and prophages. These GIs may provide some strains with a competitive advantage in the environment and/or in the host relative to other strains. Results: Here we present the results of analysis of 37 prophages, putative prophages, and prophage-like elements from six different Burkholderia species. Five of these were spontaneously induced to form bacteriophage particles from B. pseudomallei and B. thailandensis strains and were isolated and fully sequenced; 24 were computationally predicted in sequenced Burkholderia genomes; and eight are previously characterized prophages or prophage-like elements. The results reveal numerous differences in both genome structure and gene content among elements derived from different species as well as from strains within species, due in part to the incorporation of additional DNA, or 'morons' into the prophage genomes. Implications for pathogenicity are also discussed. Lastly, RNAseq analysis of gene expression showed that many of the genes in phi 1026b that appear to contribute to phage and lysogen fitness were expressed independently of the phage structural and replication genes. Conclusions: This study provides the first estimate of the relative contribution of prophages to the vast phenotypic diversity found among the Burkholderiae. C1 [Ulrich, Ricky L.; DeShazer, David] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Ronning, Catherine M.; Losada, Liliana; Brinkac, Lauren; Inman, Jason; Nierman, William C.] J Craig Venter Inst, Rockville, MD 20850 USA. [Schell, Mark] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA. [Ronning, Catherine M.] US DOE, Off Biol & Environm Res, Washington, DC 20585 USA. RP DeShazer, D (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM david.deshazer@amedd.army.mil FU U.S. Army Medical Research and Materiel Command [02-4-5X-026]; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [N01-AI-30071] FX This research was sponsored by the Medical Biological Defense Research Program, U.S. Army Medical Research and Materiel Command (project 02-4-5X-026). This project was also funded with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under contract number N01-AI-30071. NR 53 TC 22 Z9 23 U1 0 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD JUL 28 PY 2010 VL 10 AR 202 DI 10.1186/1471-2180-10-202 PG 17 WC Microbiology SC Microbiology GA 637GZ UT WOS:000280806800001 PM 20667135 ER PT J AU Hromadka, TV Whitley, RJ Jordan, N Meyer, T AF Hromadka, T. V., II Whitley, R. J. Jordan, N. Meyer, T. TI Manning's equation and two-dimensional flow analogs SO JOURNAL OF HYDROLOGY LA English DT Article DE Two-dimensional flow; Manning's equation; Mathematical modeling ID FLOODPLAIN INUNDATION; MODELS AB Two-dimensional (2D) flow models based on the well-known governing 2D flow equations are applied to floodplain analysis purposes. These 2D models numerically solve the governing flow equations simultaneously or explicitly on a discretization of the floodplain using grid tiles or similar tile cell geometry, called "elements". By use of automated information systems such as digital terrain modeling, digital elevation models, and GIS, large-scale topographic floodplain maps can be readily discretized into thousands of elements that densely cover the floodplain in an edge-to-edge form. However, the assumed principal flow directions of the flow model analog, as applied across an array of elements, typically do not align with the floodplain flow streamlines. This paper examines the mathematical underpinnings of a four-direction flow analog using an array of square elements with respect to floodplain flow streamlines that are not in alignment with the analog's principal flow directions. It is determined that application of Manning's equation to estimate the friction slope terms of the governing flow equations, in directions that are not coincident with the flow streamlines, may introduce a bias in modeling results, in the form of slight underestimation of flow depths. It is also determined that the maximum theoretical bias, occurs when a single square element is rotated by about 13, and not 45 as would be intuitively thought. The bias as a function of rotation angle for an array of square elements follows approximately the bias for a single square element. For both the theoretical single square element and an array of square elements, the bias as a function of alignment angle follows a relatively constant value from about 5 to about 85, centered at about 45. This bias was first noted about a decade prior to the present paper, and the magnitude of this bias was estimated then to be about 20% at about 10 misalignment. An adjustment of Manning's n is investigated based on a considered steady state uniform flow problem, but the magnitude of the adjustment (about 20%) is on the order of the magnitude of the accepted ranges of friction factors. For usual cases where random streamline trajectory variability within the floodplain flow is greater than a few degrees from perfect alignment, the apparent bias appears to be implicitly included in the Manning's n values. It can be concluded that the array of square elements may be applied over the digital terrain model without respect to topographic flow directions. (C) 2010 Elsevier B.V. All rights reserved. C1 [Jordan, N.] Exponent Failure Anal, Irvine, CA 92618 USA. [Hromadka, T. V., II; Meyer, T.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Whitley, R. J.] Univ Calif Irvine, Dept Math, Irvine, CA 92717 USA. RP Jordan, N (reprint author), Exponent Failure Anal, 320 Goddard Way,Ste 200, Irvine, CA 92618 USA. EM ted@phdphdphd.com; rwhitley@math.uci.edu; njordan@exponent.com; thomas.meyer@usma.edu NR 22 TC 2 Z9 2 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 J9 J HYDROL JI J. Hydrol. PD JUL 28 PY 2010 VL 389 IS 1-2 BP 177 EP 185 DI 10.1016/j.jhydrol.2010.05.044 PG 9 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 632TW UT WOS:000280452500016 ER PT J AU Garner, LE Park, J Dyar, SM Chworos, A Sumner, JJ Bazan, GC AF Garner, Logan E. Park, Juhyun Dyar, Scott M. Chworos, Arkadiusz Sumner, James J. Bazan, Guillermo C. TI Modification of the Optoelectronic Properties of Membranes via Insertion of Amphiphilic Phenylenevinylene Oligoelectrolytes SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID MICROBIAL FUEL-CELLS; THIN-FILM TRANSISTORS; FIELD-EFFECT TRANSISTORS; PI-CONJUGATED OLIGOMERS; ION-CHANNEL BEHAVIOR; 2-PHOTON ABSORPTION; ELECTRON-TRANSFER; ORGANIC SEMICONDUCTORS; DISTYRYLBENZENE CHROMOPHORES; FLUORESCENCE MICROSCOPY AB We report on the modification of membranes by incorporation of phenylenevinylene oligoelectrolytes with the goal of tailoring their optical and electronic properties and their applications. A water-soluble distyrylstilbene oligoelectrolyte (DSSN+), capped at each end with nitrogen bound, terminally charged pendant groups, was synthesized. The photophysical and solvatochromatic properties of DSSN+ and the shorter distyrylbenzene analogue DSBN+ were probed and found to be useful for characterizing insertion into membranes based on phospholipid vesicle systems. A combination of UV/visible absorbance and photoluminescence spectroscopies, together with confocal microscopy, were employed to confirm membrane incorporation. Examination of the emission intensity profile in stationary multilamellar vesicles obtained with a polarized excitation source provides insight into the orientation of these chromophores within lipid bilayers and indicates that these molecules are highly ordered, such that the hydrophobic electronically delocalized region positions within the inner membrane with the long molecular axis perpendicular to the bilayer plane. Cyclic voltammetry experiments provide evidence that DSSN+ and DSBN+ facilitate transmembrane electron transport across lipid bilayers supported on glassy carbon electrodes. Additionally, the interaction with living microorganisms was probed. Fluorescence imaging indicates that DSSN+ and DSBN+ preferentially accumulate within cell membranes. Furthermore, notable increases in yeast microbial fuel cell performance were observed when employing DSSN+ as the electron transport mediator. C1 [Garner, Logan E.; Dyar, Scott M.; Chworos, Arkadiusz; Bazan, Guillermo C.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. [Park, Juhyun] Chung Ang Univ, Sch Chem Engn & Mat Sci, Seoul 156756, South Korea. [Sumner, James J.] USA, Res Lab, Sensors & Electron Dev Directorate, Adelphi, MD 20783 USA. RP Bazan, GC (reprint author), Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. EM bazan@chem.ucsb.edu RI Socaciu, Carmen/P-8358-2014; Bazan, Guillermo/B-7625-2014 OI Socaciu, Carmen/0000-0002-7352-5057; FU Institute for Collaborative Biotechnologies [W911F-09-D-0001]; Air Force Office of Scientific Research [FA9550-08-1-0248]; National Science Foundation [DMR0606414, CMMI-0730689] FX The authors thank the Institute for Collaborative Biotechnologies (W911F-09-D-0001), Air Force Office of Scientific Research (FA9550-08-1-0248), and the National Science Foundation (DMR0606414, and subcontract from Caltech: CMMI-0730689) for financial support; Mr. Htet Khant for cryo-TEM imaging; Dr. Alexander Mikhailovsky for assistance with photophysical measurements; Dr. Joshua M. Kogot for cell cultures and helpful consultations; and Dr. Myung Chul (MC) Choi for stimulating discussions that contributed to this work. NR 92 TC 54 Z9 55 U1 5 U2 58 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JUL 28 PY 2010 VL 132 IS 29 BP 10042 EP 10052 DI 10.1021/ja1016156 PG 11 WC Chemistry, Multidisciplinary SC Chemistry GA 629VH UT WOS:000280227700038 PM 20608655 ER PT J AU Alkhalil, A Hammamieh, R Hardick, J Ichou, MA Jett, M Ibrahim, S AF Alkhalil, Abdulnaser Hammamieh, Rasha Hardick, Justin Ichou, Mohamed Ait Jett, Marti Ibrahim, Sofi TI Gene expression profiling of monkeypox virus-infected cells reveals novel interfaces for host-virus interactions SO VIROLOGY JOURNAL LA English DT Article ID INTRACELLULAR MATURE VIRION; SURFACE HEPARAN-SULFATE; PROTEIN PHOSPHATASE 2A; VACCINIA VIRUS; CYCLIN-E; DIFFERENT MECHANISMS; SIGNALING PATHWAYS; CHECKPOINT PATHWAY; EPITHELIAL-CELLS; KINASE-ACTIVITY AB Monkeypox virus (MPV) is a zoonotic Orthopoxvirus and a potential biothreat agent that causes human disease with varying morbidity and mortality. Members of the Orthopoxvirus genus have been shown to suppress antiviral cell defenses, exploit host cell machinery, and delay infection-induced cell death. However, a comprehensive study of all host genes and virus-targeted host networks during infection is lacking. To better understand viral strategies adopted in manipulating routine host biology on global scale, we investigated the effect of MPV infection on Macaca mulatta kidney epithelial cells (MK2) using GeneChip rhesus macaque genome microarrays. Functional analysis of genes differentially expressed at 3 and 7 hours post infection showed distinctive regulation of canonical pathways and networks. While the majority of modulated histone-encoding genes exhibited sharp copy number increases, many of its transcription regulators were substantially suppressed; suggesting involvement of unknown viral factors in host histone expression. In agreement with known viral dependence on actin in motility, egress, and infection of adjacent cells, our results showed extensive regulation of genes usually involved in controlling actin expression dynamics. Similarly, a substantial ratio of genes contributing to cell cycle checkpoints exhibited concerted regulation that favors cell cycle progression in G1, S, G2 phases, but arrest cells in G2 phase and inhibits entry into mitosis. Moreover, the data showed that large number of infection-regulated genes is involved in molecular mechanisms characteristic of cancer canonical pathways. Interestingly, ten ion channels and transporters showed progressive suppression during the course of infection. Although the outcome of this unusual channel expression on cell osmotic homeostasis remains unknown, instability of cell osmotic balance and membrane potential has been implicated in intracellular pathogens egress. Our results highlight the role of histones, actin, cell cycle regulators, and ion channels in MPV infection, and propose these host functions as attractive research focal points in identifying novel drug intervention sites. C1 [Alkhalil, Abdulnaser; Hardick, Justin; Ichou, Mohamed Ait; Ibrahim, Sofi] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. RP Alkhalil, A (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM naser.alkhalil@amedd.army.mil NR 95 TC 17 Z9 17 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD JUL 28 PY 2010 VL 7 AR 173 DI 10.1186/1743-422X-7-173 PG 19 WC Virology SC Virology GA 659YE UT WOS:000282602600002 PM 20667104 ER PT J AU Swanson, JP Rozvadovsky, S Seppala, JE Mackay, ME Jensen, RE Costanzo, PJ AF Swanson, John P. Rozvadovsky, Svetlana Seppala, Jonathan E. Mackay, Michael E. Jensen, Robert E. Costanzo, Philip J. TI Development of Polymeric Phase Change Materials On the basis of Diels-Alder Chemistry SO MACROMOLECULES LA English DT Article ID THERMAL-ENERGY STORAGE AB Diels-Alder (DA) chemistry is increasing popular due to its simplicity and efficiency, however, one concept that has yet to be thoroughly explored is incorporation of DA linkages within materials for the development of polymeric phase change materials It is well established that the retro-DA reaction results in a large endotherm. which could be a potential energy sink for phase change materials Hydroxyl-terminated polybutadiene (HTPB) was selected as a prepolymer and modified with different DA linkages Cured materials were prepared upon addition of diisocyanates and their physical properties of the cured elastomers were investigated using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and theological testing The resulting thermally responsive HTPB (TR-HTPB) exhibited the ability to absorb energy and flow at elevated temperatures Furthermore, they displayed unusual responses to repeated thermal cycling, including changes in thermal absorption and rheological characteristics C1 [Swanson, John P.; Rozvadovsky, Svetlana; Costanzo, Philip J.] Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA. [Seppala, Jonathan E.; Mackay, Michael E.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE USA. [Jensen, Robert E.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen, MD USA. RP Costanzo, PJ (reprint author), Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA. RI Costanzo, Philip/E-8879-2011; Swanson, John/H-3596-2016 OI Costanzo, Philip/0000-0001-6220-463X; Swanson, John/0000-0001-8820-7273 FU U S Army Research Laboratory [W911NE-08-2-0009]; California Polytechnic State University FX Funding and support provided by the U S Army Research Laboratory (W911NE-08-2-0009) Additional funding was provided by California Polytechnic State University via start-up funds Support to M E M from the University of Delaware is gratefully acknowledged Authors acknowledge Loll Nock, Mary Sherlock, and Al Stern from the Naval Surface Warfare Center, Indian I-lead Division for helpful technical discussion and direction NR 18 TC 18 Z9 18 U1 4 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JUL 27 PY 2010 VL 43 IS 14 BP 6135 EP 6141 DI 10.1021/ma100836c PG 7 WC Polymer Science SC Polymer Science GA 627PT UT WOS:000280053000032 ER PT J AU Felts, RL Narayan, K Estes, JD Shi, D Trubey, CM Fu, J Hartnell, LM Ruthel, GT Schneider, DK Nagashima, K Bess, JW Bavari, S Lowekamp, BC Bliss, D Lifson, JD Subramaniam, S AF Felts, Richard L. Narayan, Kedar Estes, Jacob D. Shi, Dan Trubey, Charles M. Fu, Jing Hartnell, Lisa M. Ruthel, Gordon T. Schneider, Douglas K. Nagashima, Kunio Bess, Julian W., Jr. Bavari, Sina Lowekamp, Bradley C. Bliss, Donald Lifson, Jeffrey D. Subramaniam, Sriram TI 3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE 3D imaging; cell-cell contact; electron tomography; viral entry; neutralizing antibodies ID HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNOLOGICAL SYNAPSE; INFECTIOUS SYNAPSE; TRANSMISSION; TYPE-1; SPREAD; CYTOSKELETON; MICROVILLI; MICROSCOPY; RESISTANT AB The efficiency of HIV infection is greatly enhanced when the virus is delivered at conjugates between CD4(+) T cells and virus-bearing antigen-presenting cells such as macrophages or dendritic cells via specialized structures known as virological synapses. Using ion abrasion SEM, electron tomography, and superresolution light microscopy, we have analyzed the spatial architecture of cell-cell contacts and distribution of HIV virions at virological synapses formed between mature dendritic cells and T cells. We demonstrate the striking envelopment of T cells by sheet-like membrane extensions derived from mature dendritic cells, resulting in a shielded region for formation of virological synapses. Within the synapse, filopodial extensions emanating from CD4(+) T cells make contact with HIV virions sequestered deep within a 3D network of surface-accessible compartments in the dendritic cell. Viruses are detected at the membrane surfaces of both dendritic cells and T cells, but virions are not released passively at the synapse; instead, virus transfer requires the engagement of T-cell CD4 receptors. The relative seclusion of T cells from the extracellular milieu, the burial of the site of HIV transfer, and the receptor-dependent initiation of virion transfer by T cells highlight unique aspects of cell-cell HIV transmission. C1 [Felts, Richard L.; Narayan, Kedar; Shi, Dan; Fu, Jing; Hartnell, Lisa M.; Subramaniam, Sriram] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Nagashima, Kunio] NCI, Electron Microscopy Lab, SAIC Frederick Inc, Frederick, MD 21702 USA. [Estes, Jacob D.; Trubey, Charles M.; Schneider, Douglas K.; Bess, Julian W., Jr.; Lifson, Jeffrey D.] NCI, AIDS & Canc Virus Program, Frederick, MD 21702 USA. [Ruthel, Gordon T.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Lowekamp, Bradley C.; Bliss, Donald] NIH, Natl Lib Med, Bethesda, MD 20892 USA. RP Subramaniam, S (reprint author), NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bldg 37, Bethesda, MD 20892 USA. EM ss1@nih.gov RI Fu, Jing/D-8512-2012; OI Fu, Jing/0000-0002-7752-5417 FU National Cancer Institute [HHSN261200800001E]; IATAP program; National Institute of General Medical Sciences FX This work was supported by funds from the intramural program of the National Cancer Institute and the IATAP program (to S. S.) and federal funds from the National Cancer Institute under Contract HHSN261200800001E (to J.D.L.). R. L. F. was supported in part by a Pharmacology Research Associate Fellowship from the National Institute of General Medical Sciences. NR 38 TC 91 Z9 91 U1 5 U2 21 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUL 27 PY 2010 VL 107 IS 30 BP 13336 EP 13341 DI 10.1073/pnas.1003040107 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 634RW UT WOS:000280602800029 PM 20624966 ER PT J AU Moore, EW Lee, S Hickman, SA Harrell, LE Marohn, JA AF Moore, Eric W. Lee, SangGap Hickman, Steven A. Harrell, Lee E. Marohn, John A. TI Evading surface and detector frequency noise in harmonic oscillator measurements of force gradients SO APPLIED PHYSICS LETTERS LA English DT Article DE cantilevers; force measurement; force sensors; harmonic oscillators; noise; paramagnetic resonance ID PARAMETRIC AMPLIFICATION; SENSITIVITY; CANTILEVERS; RESONANCE; PROBE AB We introduce and demonstrate a method of measuring small force gradients acting on a harmonic oscillator in which the force-gradient signal of interest is used to parametrically up-convert a forced oscillation below resonance into an amplitude signal at the oscillator's resonance frequency. The approach, which we demonstrate in a mechanically detected electron spin resonance experiment, allows the force-gradient signal to evade detector frequency noise by converting a slowly modulated frequency signal into an amplitude signal. (C) 2010 American Institute of Physics. [doi:10.1063/1.3465906] C1 [Moore, Eric W.; Lee, SangGap; Hickman, Steven A.; Marohn, John A.] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA. [Harrell, Lee E.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. RP Moore, EW (reprint author), Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA. EM jam99@cornell.edu OI Harrell, Lee/0000-0003-2305-5787 FU National Institutes of Health [5R01GM-070012]; Army Research Office Multi-University Research Initiative [W911NF-05-1-0403]; National Science Foundation [ECS-0335765] FX We acknowledge National Institutes of Health Grant No. 5R01GM-070012 and Army Research Office Multi-University Research Initiative Grant No. W911NF-05-1-0403. This work was performed in part at the Cornell NanoScale Science and Technology Facility, a member of the National Nanotechnology Infrastructure Network, which is supported by National Science Foundation Grant No. ECS-0335765. E. W. M. and S. L. contributed equally to this work. NR 12 TC 5 Z9 5 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 26 PY 2010 VL 97 IS 4 AR 044105 DI 10.1063/1.3465906 PG 3 WC Physics, Applied SC Physics GA 640NV UT WOS:000281059200112 ER PT J AU Sanders, JL Lawrence, C Nichols, DK Brubaker, JF Peterson, TS Murray, KN Kent, ML AF Sanders, Justin L. Lawrence, Christian Nichols, Donald K. Brubaker, Jeffrey F. Peterson, Tracy S. Murray, Katrina N. Kent, Michael L. TI Pleistophora hyphessobryconis (Microsporidia) infecting zebrafish Danio rerio in research facilities SO DISEASES OF AQUATIC ORGANISMS LA English DT Article DE Zebrafish; Microsporidia; Pleistophora hyphessobryconis ID SALMON ONCORHYNCHUS-TSHAWYTSCHA; PSEUDOLOMA-NEUROPHILIA; MODEL SYSTEM; FISH; VERTEBRATE; PHYLOGENY; GENUS; TRANSMISSION; N. AB Zebrafish Damo rerio are important models for biomedical research, and thus, there is an increased concern about diseases afflicting them Here we describe infections by Pleistophora hyphessobryconis (Microsporidia) in zebrafish from 3 laboratories As reported in other aquarium fishes, affected zebrafish exhibited massive infections in the skeletal muscle, with no involvement of smooth or cardiac muscle. In addition, numerous spores within macrophages were observed in the visceral organs, including the ovaries Transmission studies and ribosomal RNA (rRNA) gene sequence comparisons confirmed that the parasite from zebrafish was P hyphessobryconis as described from neon tetra Parachenodon nines,. Ten 15 d old zebrafish were exposed to P hyphessobryconis collected from 1 infected neon tetra, and 7 of 10 fish became infected. Comparison of P. hyphessobryconis small subunit rRNA gene sequence from neon tetra with that obtained from zebrafish was nearly identical, with <1% difference Given the severity of infections, P hyphessobryconis should be added to the list of pathogens that should be avoided in zebrafish research facilities, and it would be prudent to avoid mixing zebrafish used in research with other aquarium fishes C1 [Sanders, Justin L.; Peterson, Tracy S.; Kent, Michael L.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA. [Lawrence, Christian] Childrens Hosp, Aquat Resources Program, Boston, MA 02115 USA. [Nichols, Donald K.] USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA. [Nichols, Donald K.; Brubaker, Jeffrey F.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Murray, Katrina N.] Univ Oregon, Zebrafish Int Resource Ctr, Eugene, OR 97403 USA. RP Sanders, JL (reprint author), Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA. RI Sanders, Justin/F-5977-2011 FU National Institutes of Health (NIH NCRR) [5R24RR017386-02, P40 RR12546-03S1] FX This study was supported by grants from the National Institutes of Health (NIH NCRR 5R24RR017386-02 and NIH NCRR P40 RR12546-03S1). Mention of a brand name does not imply endorsement of the product by the U S Federal Government Opinions, interpretations, conclusions, and recommendations stated are those of the authors and are not necessarily endorsed by the U.S Army We thank G Sanders, University of Washington, for manuscript review, NI Schuster for assistance in translation of German references, and K. Berkenkamp for histology slide preparation and technical support NR 46 TC 27 Z9 27 U1 0 U2 9 PU INTER-RESEARCH PI OLDENDORF LUHE PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY SN 0177-5103 J9 DIS AQUAT ORGAN JI Dis. Aquat. Org. PD JUL 26 PY 2010 VL 91 IS 1 BP 47 EP 56 DI 10.3354/dao02245 PG 10 WC Fisheries; Veterinary Sciences SC Fisheries; Veterinary Sciences GA 646EC UT WOS:000281518500006 PM 20853741 ER PT J AU Johnson, EA Kan, RK AF Johnson, Erik A. Kan, Robert K. TI The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations SO JOURNAL OF NEUROINFLAMMATION LA English DT Article ID EXCITOTOXIC NEURONAL DAMAGE; CEREBRAL-ISCHEMIA; INDUCED SEIZURES; ALZHEIMERS-DISEASE; TNF-ALPHA; INTERLEUKIN-1; INJURY; NEUROPROTECTION; NEUROPATHOLOGY; NEURODEGENERATION AB Background: Neuroinflammation occurs following brain injury, including soman (GD) induced status epilepticus (SE), and may contribute to loss of neural tissue and declined behavioral function. However, little is known about this important pathological process following GD exposure. Limited transcriptional information on a small number of brain-expressed inflammatory mediators has been shown following GD-induced SE and even less information on protein upregulation has been elucidated. The purpose of this study is to further characterize the regional and temporal progression of the neuroinflammatory process following acute GD-induced SE. Methods: The protein levels of 10 cytokines was quantified using bead multiplex immunoassays in damaged brain regions (i.e., piriform cortex, hippocampus and thalamus) up to 72 hours following seizure onset. Those factors showing significant changes were then localized to neural cells using fluorescent IHC. Results: A significant concentration increase was observed in all injured brain regions for four acute phase response (APR) induction cytokines: interleukin (IL)-1 alpha, IL-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha. Increases in these APR cytokines corresponded both temporally and regionally to areas of known seizure damage and neuronal death. Neurotoxic cytokines IL-1 alpha and IL-1 beta were primarily expressed by activated microglia whereas the potentially neuroprotective cytokine IL-6 was expressed by neurons and hypertrophic astrocytes. Conclusions: Increases in neurotoxic cytokines likely play an active role in the progression of GD-induced SE neuropathology though the exact role that these and other cytokines play in this process require further study. C1 [Johnson, Erik A.; Kan, Robert K.] USA, Med Res Inst Chem Def USAMRICD, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Johnson, EA (reprint author), USA, Med Res Inst Chem Def USAMRICD, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. EM erik.a.johnson1@us.army.mil FU US Army Medical Research; Defense Threat Reduction Agency [110001_04_RC_C, W911NF-07-D-001] FX The authors would like to thank Thuy Dao, Andrew Koemeter-Cox, Michelle Guignet, Claire Geddes and Jennifer Peeling for their expert technical support and Dr. Wolfgang Streit, University of Florida College of Medicine, for his assistance in identifying dystrophic microglia. This work was supported by the US Army Medical Research and Materiel Command and by the Defense Threat Reduction Agency (110001_04_RC_C and W911NF-07-D-001). The findings contained herein are the private views of the author(s) and are not to be construed as official or as reflecting the views of the US Army or Department of Defense. NR 50 TC 35 Z9 37 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD JUL 22 PY 2010 VL 7 AR 40 DI 10.1186/1742-2094-7-40 PG 9 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 657AU UT WOS:000282384100001 PM 20649973 ER PT J AU Kudenov, MW Jungwirth, MEL Dereniak, EL Gerhart, GR AF Kudenov, Michael W. Jungwirth, Matthew E. L. Dereniak, Eustace L. Gerhart, Grant R. TI White-light Sagnac interferometer for snapshot multispectral imaging SO APPLIED OPTICS LA English DT Article ID CHLOROPHYLL CONTENT; POLARIMETER; REFLECTANCE; CALIBRATION AB The theoretical and experimental demonstration of a multispectral Sagnac interferometer (MSI) is presented. The MSI was created by including two multiple-order blazed diffraction gratings in both arms of a standard polarization Sagnac interferometer (PSI). By introducing these high-order diffractive structures, unique spectral passbands can be amplitude modulated onto coincident carrier frequencies. Extraction of the modulated multispectral images, corresponding to each passband, is accomplished within the Fourier domain. This yields a unique multispectral sensor capable of imaging all the passbands in a single snapshot. First, the theoretical operating principles of a PSI are discussed to provide a context for the MSI. This is followed by the theoretical and experimental development of the MSI, which is an extension of a dispersion-compensated PSI. Indoor and outdoor testing and validation of the MSI are performed by observing vegetation, demonstrating the ability of our experimental setup to detect four distinct spectral passbands. (C) 2010 Optical Society of America C1 [Kudenov, Michael W.; Jungwirth, Matthew E. L.; Dereniak, Eustace L.] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. [Gerhart, Grant R.] US Army TACOM, Warren, MI 48397 USA. RP Kudenov, MW (reprint author), Univ Arizona, Coll Opt Sci, 1630 E Univ Blvd, Tucson, AZ 85721 USA. EM mike.kudenov@gmail.com NR 19 TC 12 Z9 13 U1 1 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 2010 VL 49 IS 21 BP 4067 EP 4076 DI 10.1364/AO.49.004067 PG 10 WC Optics SC Optics GA 628LY UT WOS:000280122800008 PM 20648191 ER PT J AU Reddy, G Song, JA Mecchi, MS Johnson, MS AF Reddy, Gunda Song, Jian Mecchi, Michael S. Johnson, Mark S. TI Genotoxicity assessment of two hypergolic energetic propellant compounds SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS LA English DT Article DE Dimethylamino-2-ethylazide; DMAZ; Genotoxicity; Mutagenicity; N,N,N ',N '-Tetramethylethanediamine; TMEDA ID HAMSTER OVARY CELLS; SISTER-CHROMATID EXCHANGES; MICRONUCLEUS ASSAY; MUTAGENICITY TEST; SPECIFICITY; HYDRAZINES; DROSOPHILA; INDUCTION; CHEMICALS AB Recognition of the occupational hazards from exposure to the propellants hydrazine and monomethyl-hydrazine (MMH) has led to research into less toxic alternatives. Two hypergolic compounds, dimethylamino-2-ethylazide (DMAZ) and N,N,N',N'-tetramethylethanediamine (TMEDA), have been identified as possible replacements for MMH. We have obtained genotoxicity data for these compounds from in vitro and in vivo studies. DMAZ did not produce any mutagenic effects at concentrations up to 5 mg/plate in the TA98 and TA1537 strains of Salmonella typhimurium and in an Escherichia coli (WP2 uvrA) strain, with or without metabolic activation, but did produce a positive response in the TA100 and TA1535 strains, both with and without metabolic activation. TMEDA was found not to be mutagenic in any of the bacterial strains tested (Salmonella TA98, TA100, TA1535, TA1537 and E. coli, WP2 uvrA), with or without metabolic activation. DMAZ did not induce structural chromosomal aberrations at levels up to 5 mg/mL in Chinese hamster ovary (CHO) cells, with or without metabolic activation. TMEDA produced a positive response in this system, with or without metabolic activation, but only at the highest concentration, 5 mg/mL.. However, according to the OECD guideline TG 473, the compound is considered to be negative in the CHO chromosomal aberration assay, since the compound was not clastogenic at 0.01 M (1.140 mg/mL). DMAZ and TMEDA, when tested in vivo in the CD-1 mouse at doses up to 500 and 250 mg/kg, respectively, did not induce micronuclei in bone marrow erythrocytes. These studies demonstrate that DMAZ is mutagenic in specific strains of Salmonella. However, both compounds were negative for induction of chromosomal aberrations in CHO cells in vitro and in the in vivo mouse micronucleus assay. (C) 2010 Elsevier B.V. All rights reserved. C1 [Reddy, Gunda; Johnson, Mark S.] USA, Publ Hlth Command Provis, Directorate Toxicol, Aberdeen Proving Ground, MD 21010 USA. [Song, Jian] SITEK Res Lab, Rockville, MD 20850 USA. [Mecchi, Michael S.] Covance Labs Inc, Vienna, VA 22182 USA. RP Reddy, G (reprint author), USA, Publ Hlth Command Provis, Directorate Toxicol, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM gunda.reddy@us.army.mil FU U.S. Army Research, Development and Engineering Command (RDECOM) FX This work was funded by the U.S. Army Environmental Quality Technology (EQT) Ordnance Environmental Program (OEP) of the U.S. Army Research, Development and Engineering Command (RDECOM). We would like to thank Dr. Erik Hangland, Dr. Wiliam Ruppert and Dr. LaShanda Felton for their continued interest in and support of this effort. We thank Dr. William S. Eck for a critical review of the manuscript. NR 31 TC 14 Z9 14 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1383-5718 J9 MUTAT RES-GEN TOX EN JI Mutat. Res. Genet. Toxicol. Environ. Mutagen. PD JUL 19 PY 2010 VL 700 IS 1-2 BP 26 EP 31 DI 10.1016/j.mrgentox.2010.04.019 PG 6 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology GA 629SC UT WOS:000280219000004 PM 20417306 ER PT J AU Felton, M Gurton, KP Pezzaniti, JL Chenault, DB Roth, LE AF Felton, M. Gurton, K. P. Pezzaniti, J. L. Chenault, D. B. Roth, L. E. TI Measured comparison of the crossover periods for mid- and long-wave IR (MWIR and LWIR) polarimetric and conventional thermal imagery SO OPTICS EXPRESS LA English DT Article AB We report the results of a multi-day diurnal study in which polarimetric and conventional thermal imagery is recorded in the mid- and long-wave IR to identify and compare the respective time periods in which minimum target contrast is achieved. The data shows that the chief factors affecting polarimetric contrast in both wavebands are the amount of thermal emission from the objects in the scene and the abundance of MWIR and LWIR sources in the optical background. In particular, it has been observed that the MWIR polarimetric contrast was positively correlated to the presence of MWIR sources in the optical background, while the LWIR polarimetric contrast was negatively correlated to the presence of LWIR sources in the optical background. (C) 2010 Optical Society of America C1 [Felton, M.; Gurton, K. P.] USA, Res Lab, Adelphi, MD 20783 USA. [Pezzaniti, J. L.; Chenault, D. B.] Polaris Sensor Technol Inc, Huntsville, AL 35801 USA. [Roth, L. E.] USA, Armament Res & Dev Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Felton, M (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mfelton@arl.army.mil NR 10 TC 16 Z9 16 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUL 19 PY 2010 VL 18 IS 15 BP 15704 EP 15713 DI 10.1364/OE.18.015704 PG 10 WC Optics SC Optics GA 635YG UT WOS:000280693300049 PM 20720953 ER PT J AU Danylov, AA Goyette, TM Waldman, J Coulombe, MJ Gatesman, AJ Giles, RH Qian, XF Chandrayan, N Vangala, S Termkoa, K Goodhue, WD Nixon, WE AF Danylov, Andriy A. Goyette, Thomas M. Waldman, Jerry Coulombe, Michael J. Gatesman, Andrew J. Giles, Robert H. Qian, Xifeng Chandrayan, Neelima Vangala, Shivashankar Termkoa, Krongtip Goodhue, William D. Nixon, William E. TI Terahertz inverse synthetic aperture radar (ISAR) imaging with a quantum cascade laser transmitter SO OPTICS EXPRESS LA English DT Article ID PHASE-LOCKING; THZ; FREQUENCY AB A coherent transceiver using a THz quantum cascade (TQCL) laser as the transmitter and an optically pumped molecular laser as the local oscillator has been used, with a pair of Schottky diode mixers in the receiver and reference channels, to acquire high-resolution images of fully illuminated targets, including scale models and concealed objects. Phase stability of the received signal, sufficient to allow coherent image processing of the rotating target ( in azimuth and elevation), was obtained by frequency-locking the TQCL to the free-running, highly stable optically pumped molecular laser. While the range to the target was limited by the available TQCL power ( several hundred microwatts) and reasonably strong indoor atmospheric attenuation at 2.408 THz, the coherence length of the TQCL transmitter will allow coherent imaging over distances up to several hundred meters. Image data obtained with the system is presented. (C) 2010 Optical Society of America C1 [Danylov, Andriy A.; Goyette, Thomas M.; Waldman, Jerry; Coulombe, Michael J.; Gatesman, Andrew J.; Giles, Robert H.] Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. [Qian, Xifeng; Chandrayan, Neelima; Vangala, Shivashankar; Termkoa, Krongtip; Goodhue, William D.] Univ Massachusetts Lowell, Photon Ctr, Lowell, MA 01854 USA. [Nixon, William E.] USA, Natl Ground Intelligence Ctr, Charlottesville, VA 22911 USA. RP Danylov, AA (reprint author), Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. EM Andriy_Danylov@student.uml.edu FU U.S. Army National Ground Intelligence Center FX This work was supported by the U.S. Army National Ground Intelligence Center. NR 22 TC 33 Z9 42 U1 13 U2 42 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUL 19 PY 2010 VL 18 IS 15 BP 16264 EP 16272 DI 10.1364/OE.18.016264 PG 9 WC Optics SC Optics GA 635YG UT WOS:000280693300108 PM 20721012 ER PT J AU Petrikovics, I Kuzmitcheva, G Haines, D Budai, M Childress, J Nagy, A Rockwood, G AF Petrikovics, I. Kuzmitcheva, G. Haines, D. Budai, M. Childress, J. Nagy, A. Rockwood, G. TI Encapsulated rhodanese with two new sulfur donors in cyanide antagonism SO TOXICOLOGY LETTERS LA English DT Meeting Abstract C1 [Rockwood, G.] USA, Med Res Inst Chem Def, Washington, DC USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD JUL 17 PY 2010 VL 196 SU S BP S144 EP S144 DI 10.1016/j.toxlet.2010.03.500 PG 1 WC Toxicology SC Toxicology GA V25II UT WOS:000208471300443 ER PT J AU Shih, TM Guarisco, JA Koplovitz, I Kan, RK Myers, TM Mcdonough, JH AF Shih, T. M. Guarisco, J. A. Koplovitz, I. Kan, R. K. Myers, T. M. Mcdonough, J. H. TI The oxime Pro-2-PAM provides minimal protection against the CNS effects of the organophosphorus nerve agents sarin, cyclosarin, and VX in guinea pigs SO TOXICOLOGY LETTERS LA English DT Meeting Abstract C1 [Shih, T. M.; Guarisco, J. A.; Koplovitz, I.; Kan, R. K.; Myers, T. M.; Mcdonough, J. H.] USA, Med Res Inst Chem Def, Washington, DC USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD JUL 17 PY 2010 VL 196 SU S BP S271 EP S271 DI 10.1016/j.toxlet.2010.03.899 PG 1 WC Toxicology SC Toxicology GA V25II UT WOS:000208471301367 ER PT J AU Villeneuve, DL Garcia-Reyero, N Martinovic, D Cavallin, JE Mueller, ND Wehmas, LC Kahl, MD Linnum, AL Perkins, EJ Ankley, GT AF Villeneuve, Daniel L. Garcia-Reyero, Natalia Martinovic, Dalma Cavallin, Jenna E. Mueller, Nathaniel D. Wehmas, Leah C. Kahl, Michael D. Linnum, Anne L. Perkins, Edward J. Ankley, Gerald T. TI Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue SO AQUATIC TOXICOLOGY LA English DT Article DE Oogenesis; Toxicogenomics; Reproduction; Histology ID AROMATASE INHIBITOR FADROZOLE; TERM REPRODUCTION ASSAY; ZEBRAFISH DANIO-RERIO; GENE-EXPRESSION; SELENOPROTEIN-P; GRANULOSA-CELLS; OOCYTE GROWTH; FISH; PROTEIN; LOCALIZATION AB Interpretation of toxicogenomic experiments conducted with ovary tissue from asynchronous-spawning small fish species is complicated by background variation in the relative abundance and proportion of follicles at different stages within the ovary tissue sample. This study employed both real-time quantitative polymerase chain reaction and a 15,000 gene oligonucleotide microarray to examine variation in the fathead minnow (Pimephales promelas) ovarian transcriptional profile as a function of quantitative and qualitative differences in ovarian histology. The objectives were to provide data that could potentially aid interpretation of future toxicogenomics experiments, identify putative stage-related transcriptional markers, and generate insights into basic biological regulation of asynchronous oocyte development. Multiple lines of evidence from the present study indicate that variation in the transcriptional profile is primarily dependent on the relative abundance of previtellogenic versus vitellogenic follicles in the ovary. Due to the relatively small proportions of mature ovulated follicles or atretic follicles in the overall follicle population, few potential transcriptional markers of maturation, ovulation, or atresia could be identified. However, among the 460 differentially expressed genes identified in the present study, several targets, including HtrA serine peptidase 3 (htra3), tissue inhibitor of metalloproteinase 3 (timp3), aquaporin 8 (aqp8), transgelin 2 like (tagln2), Nedd4 family interacting protein 2 (ndfip2), chemokine ligand 12a (cxcl12a), midkine-related growth factor (mdka), and jagged 1b (jag 1b) exhibited responses and functional properties that support them as candidate molecular markers of significant shift in gross ovarian stage. Genes associated with a diversity of functions including cellular development, morphogenesis, coated vesicle transport, sexual reproduction, and neuron development, among others, were statistically enriched within the list of 460 genes differentially expressed among different ovarian classes. Overall, results of this study provide insights into background variation in ovary transcript profiles that should aid and enhance the interpretation of toxicogenomic data generated in experiments conducted with small, asynchronous-spawning fish species. Published by Elsevier B.V. C1 [Villeneuve, Daniel L.; Martinovic, Dalma; Cavallin, Jenna E.; Mueller, Nathaniel D.; Wehmas, Leah C.; Kahl, Michael D.; Linnum, Anne L.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Martinovic, Dalma] Univ St Thomas, Dept Biol, St Paul, MN 55105 USA. [Perkins, Edward J.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39108 USA. RP Villeneuve, DL (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM villeneuve.dan@epa.gov RI Mueller, Nathaniel/E-5864-2010; OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965 FU US EPA National Center for Computational Toxicology; US Army Corps of Engineers FX The authors thank Lynn Escalon for technical assistance with microarray hybridizations. The microarrays used in the present study were designed and annotated by Dr. Nancy Denslow and Dr. Li Liu of the University of Florida. Dr. Liu and colleagues also conducted reciprocal best hit analyses to identify homologous features between the fathead minnow microarray (CEO accession GPL9248) and the zebrafish microarray used by Villeneuve et al. (2009b). We thank Dr. Rodney Johnson and Dr. Chris Martyniuk for comments on an earlier version of this manuscript. This work was supported in part by the US EPA National Center for Computational Toxicology and the Army Environmental Quality Program of the US Army Corps of Engineers. The manuscript has been reviewed in accordance with US EPA and US ACE guidelines and approved for publication. Approval does not indicate that the contents reflect the views of either Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 51 TC 22 Z9 24 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X J9 AQUAT TOXICOL JI Aquat. Toxicol. PD JUL 15 PY 2010 VL 98 IS 4 BP 354 EP 366 DI 10.1016/j.aquatox.2010.03.006 PG 13 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA 613MG UT WOS:000278982800006 PM 20363515 ER PT J AU Yang, J Marriner, GA Wang, XY Bowman, PD Kerwin, SM Stavchansky, S AF Yang, John Marriner, Gwendolyn A. Wang, Xinyu Bowman, Phillip D. Kerwin, Sean M. Stavchansky, Salomon TI Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: Comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE) SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE Oxidative stress; Hydrogen peroxide; Ischemia/reperfusion injury; CAPE ID HUMAN ENDOTHELIAL-CELLS; OXIDATIVE STRESS; HEME OXYGENASE-1; ANALOGS; RATS; ISCHEMIA/REPERFUSION; CYTOTOXICITY; REPERFUSION; INHIBITION; STABILITY AB A series of catechol ring-fluorinated derivatives of caffeic acid phenethyl amide (CAPA) were synthesized and screened for cytoprotective activity against H(2)O(2) induced oxidative stress in human umbilical vein endothelial cells (HUVEC). CAPA and three fluorinated analogs were found to be significantly cytoprotective when compared to control, with no significant difference in cytoprotection between caffeic acid phenethyl ester (CAPE) and CAPA. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Marriner, Gwendolyn A.; Kerwin, Sean M.] Univ Texas Austin, Div Med Chem, Austin, TX 78712 USA. [Marriner, Gwendolyn A.; Kerwin, Sean M.] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA. [Yang, John; Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Div Pharmaceut, Coll Pharm, Austin, TX 78712 USA. [Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Kerwin, SM (reprint author), Univ Texas Austin, Div Med Chem, Austin, TX 78712 USA. EM skerwin@mail.utexas.edu; stavchansky@mai-l.utexas.edu OI Kerwin, Sean/0000-0001-8432-6558 FU US Army Institute of Surgical Research; Robert Welch Foundation [F-1298, H-F-0032]; [TI-3D] FX This project was supported by the US Army Institute of Surgical Research, the Robert Welch Foundation (F-1298 and H-F-0032) and the TI-3D. NR 33 TC 17 Z9 17 U1 0 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD JUL 15 PY 2010 VL 18 IS 14 BP 5032 EP 5038 DI 10.1016/j.bmc.2010.05.080 PG 7 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 623MN UT WOS:000279744700020 PM 20598894 ER PT J AU Venugopal, D Klapper, D Srouji, AH Bhonsle, JB Borschel, R Mueller, A Russell, AL Williams, BC Hicks, RP AF Venugopal, Divakaramenon Klapper, David Srouji, Antoine H. Bhonsle, Jayendra B. Borschel, Richard Mueller, Allen Russell, Amanda L. Williams, Brittany C. Hicks, Rickey P. TI Novel antimicrobial peptides that exhibit activity against select agents and other drug resistant bacteria SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE Antimicrobial peptides; In vitro activity; Select bacterial agents; MRSA ID MAGAININ 2 AMIDE; ANTIBACTERIAL ACTIVITY; BURKHOLDERIA-PSEUDOMALLEI; PHOSPHOLIPID-MEMBRANES; AMPHIPATHIC PEPTIDES; BIOLOGICAL-ACTIVITY; CATIONIC PEPTIDES; MODEL MEMBRANES; LIPID-MEMBRANES; LYTIC PEPTIDES AB One of the greatest challenges facing modern medicine is the evolution of drug resistant strains of bacteria. In addition to traditional methods of exposure to traditional bacterial organisms there is a growing concerned of the use of bacteria as bio-terrorism agents. To counter the evolution of drug resistant and potential bio-terrorism bacterial agents new antibiotic drugs must be developed. One potential source of new therapeutic agents that act via a novel mechanism of action are natural and synthetic antimicrobial peptides (AMPs). In our laboratories we have developed a series of AMPs incorporating the un-natural amino acids Tic-Oic to impart organism selectivity and potency while increasing metabolic stability. Herein the in vitro activity of these peptides, including ten new compounds, against eight potential bio-terrorism bacterial agents and three other bacterial strains is presented and discussed. These peptides exhibit a wide range of organism potency and selectivity. Calcein fluorescence leakage and circular dichroism studies were conducted to confirm that these peptides interact with zwitterionic and anionic liposomes. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Venugopal, Divakaramenon; Russell, Amanda L.; Williams, Brittany C.; Hicks, Rickey P.] E Carolina Univ, Dept Chem, Greenville, NC 27858 USA. [Klapper, David] Univ N Carolina, Sch Med, Peptide Core Facil, Chapel Hill, NC USA. [Bhonsle, Jayendra B.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Srouji, Antoine H.] Synthet Prote, Carlsbad, CA USA. [Borschel, Richard; Mueller, Allen] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Hicks, RP (reprint author), E Carolina Univ, Dept Chem, Sci & Technol Bldg, Greenville, NC 27858 USA. EM hicksr@ecu.edu FU Defense Threat Reduction Agency; North Carolina Biotechnology Center [2006-FRG-1015]; East Carolina University; [W81XWH-08-2-0095] FX The authors would like to acknowledge funding from the Bacterial Therapeutics Program 2.1 of the Defense Threat Reduction Agency. Contract # W81XWH-08-2-0095. The authors would also like to acknowledge funding from the North Carolina Biotechnology Center Grant number 2006-FRG-1015 and from East Carolina University. NR 100 TC 17 Z9 23 U1 3 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD JUL 15 PY 2010 VL 18 IS 14 BP 5137 EP 5147 DI 10.1016/j.bmc.2010.05.065 PG 11 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 623MN UT WOS:000279744700032 PM 20558071 ER PT J AU Crowe, SR Ash, LL Engler, RJM Ballard, JD Harley, JB Farris, AD James, JA AF Crowe, Sherry R. Ash, Linda L. Engler, Renata J. M. Ballard, Jimmy D. Harley, John B. Farris, A. Darise James, Judith A. TI Select Human Anthrax Protective Antigen Epitope-Specific Antibodies Provide Protection from Lethal Toxin Challenge SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; BACILLUS-ANTHRACIS; MONOCLONAL-ANTIBODIES; NEUTRALIZING ANTIBODIES; INHALATIONAL ANTHRAX; PASSIVE PROTECTION; IMMUNE-RESPONSES; GUINEA-PIGS; IN-VITRO; VACCINE AB Bacillus anthracis remains a serious bioterrorism concern, and the currently licensed vaccine remains an incomplete solution for population protection from inhalation anthrax and has been associated with concerns regarding efficacy and safety. Thus, understanding how to generate long-lasting protective immunity with reduced immunizations or provide protection through postexposure immunotherapeutics are long-sought goals. Through evaluation of a large military cohort, we characterized the levels of antibodies against protective antigen and found that over half of anthrax vaccinees had low serum levels of in vitro toxin neutralization capacity. Using solid-phase epitope mapping and confirmatory assays, we identified several neutralization-associated humoral epitopes and demonstrated that select antipeptide responses mediated protection in vitro. Finally, passively transferred antibodies specific for select epitopes provided protection in an in vivo lethal toxin mouse model. Identification of these antigenic regions has important implications for vaccine design and the development of directed immunotherapeutics. C1 [Crowe, Sherry R.; Ash, Linda L.; Harley, John B.; Farris, A. Darise; James, Judith A.] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. [Ballard, Jimmy D.; Harley, John B.; Farris, A. Darise; James, Judith A.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. [Harley, John B.] US Dept Vet Affairs, Med Ctr, Oklahoma City, OK USA. [Engler, Renata J. M.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Washington, DC 20307 USA. RP James, JA (reprint author), Clin Immunol Program, 825 NE 13th St, Oklahoma City, OK 73104 USA. EM jamesj@omrf.org FU National Institute of Allergy and Infectious Diseases [U19AI062629]; National Center for Research Resources [P20RR15577]; Walter Reed Army Medical Center Vaccine Healthcare Centers Network and Allergy-Immunology Department FX National Institute of Allergy and Infectious Diseases (grant U19AI062629); National Center for Research Resources (grant P20RR15577); Walter Reed Army Medical Center Vaccine Healthcare Centers Network and Allergy-Immunology Department (local protocol development and management). NR 47 TC 20 Z9 20 U1 0 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUL 15 PY 2010 VL 202 IS 2 BP 251 EP 260 DI 10.1086/653495 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 612VL UT WOS:000278932900010 PM 20533877 ER PT J AU Fallas, JC Chien, WM Chandra, D Kamisetty, VK Emmons, ED Covington, AM Chellappa, R Gramsch, SA Hemley, RJ Hagemann, H AF Fallas, Juan C. Chien, Wen-Ming Chandra, Dhanesh Kamisetty, Vamsi K. Emmons, Erik D. Covington, Aaron M. Chellappa, Raja Gramsch, Stephen A. Hemley, Russell J. Hagemann, Hans TI Raman Spectroscopy Measurements of the Pressure-Temperature Behavior of LiAlH4 SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID INDUCED PHASE-TRANSITIONS; LITHIUM ALUMINUM-HYDRIDE; X-RAY-DIFFRACTION; THERMAL-DECOMPOSITION; NEUTRON; TRANSFORMATIONS; SCATTERING; STORAGE; NAALH4; LIBH4 AB The pressure/temperature phase diagram of LiAlH4 has been constructed by using Raman spectroscopy data. In situ high pressure temperature experiments were carried out using resistively heated diamond anvil cells up to 150 degrees C and 7 GPa. Room temperature phase transitions of monoclinic alpha-LiAlH4 -> delta-LiAlH4 were observed at similar to 3.2 GPa. As the temperature is increased to similar to 100 degrees C, both the alpha and delta phases transform to beta-LiAlH4 and remain stable up to 5.5 GPa. At temperatures greater than 300 degrees C, a new gamma-LiAlH4 phase forms. Data of Konovalov (1995) has been used to define the phase boundary between beta- and gamma-LiAlH4 phases. We present a pressure temperature phase diagram of LiAlH4 based using diamond anvil cells coupled with Raman spectroscopy. C1 [Fallas, Juan C.; Chien, Wen-Ming; Chandra, Dhanesh; Kamisetty, Vamsi K.] Univ Nevada, Mat Sci & Engn Div, Dept Chem & Met Engn MS 388, Reno, NV 89557 USA. [Emmons, Erik D.] USA, Edgewood Chem Biol Ctr, AMSRD ECB RT DL BLDG E5560, Aberdeen Proving Ground, MD 21010 USA. [Covington, Aaron M.] Univ Nevada, Dept Phys, Reno, NV 89557 USA. [Covington, Aaron M.] Univ Nevada, Nevada Terawatt Facil MS 220, Reno, NV 89557 USA. [Chellappa, Raja; Gramsch, Stephen A.; Hemley, Russell J.] Carnegie Inst Sci, Geophys Lab, Washington, DC 20015 USA. [Hagemann, Hans] Univ Geneva, Dept Phys Chem, CH-1211 Geneva, Switzerland. RP Chandra, D (reprint author), Univ Nevada, Mat Sci & Engn Div, Dept Chem & Met Engn MS 388, Reno, NV 89557 USA. EM dchandra@unr.edu FU US DOE [DE-FC-03-03NA00144, DEFC52-06NA27616]; Carnegie Institution of Washington FX We thank our DOE funding agency for the support of the program (CDAC: DE-FC-03-03NA00144). We gratefully acknowledge the support of Carnegie Institution of Washington. We also thank the Optical Properties of Materials Laboratory, UNR, and gratefully acknowledge support from the US DOE under Grant No. DEFC52-06NA27616. J.C.F. acknowledges the Costa Rican National Council of Science and Technology (CONICIT). NR 36 TC 8 Z9 8 U1 3 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 15 PY 2010 VL 114 IS 27 BP 11991 EP 11997 DI 10.1021/jp1015017 PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 620NZ UT WOS:000279507900045 ER PT J AU Tewari, A Kokil, A Ravichandran, S Nagarajan, S Bouldin, R Samuelson, LA Nagarajan, R Kumar, J AF Tewari, Arti Kokil, Akshay Ravichandran, Sethumadhavan Nagarajan, Subhalakshmi Bouldin, Ryan Samuelson, Lynne A. Nagarajan, Ramaswamy Kumar, Jayant TI Soybean Peroxidase Catalyzed Enzymatic Synthesis of Pyrrole/EDOT Copolymers SO MACROMOLECULAR CHEMISTRY AND PHYSICS LA English DT Article DE conducting polymers; enzymatic polymerizations; PEDOT; polypyrrole; soybean peroxidase ID GLUCOSE-OXIDASE; SOLUBLE POLYPYRROLE; ORGANIC POLYMERS; NOBEL LECTURE; REDOX ENZYME; 3,4-ETHYLENEDIOXYTHIOPHENE; POLYMERIZATION; NANOPARTICLES; POLYANILINE; CHEMISTRY AB Pyrrole/EDOT copolymers were synthesized using environmentally benign enzyme catalysis. PSS was used as the solubilizing template and charge-balancing dopant. Soybean peroxidase was utilized as a catalyst for the copolymerization reactions to yield poly(pyrrole-EDOT)/PSS complex. Systematic studies were conducted with varying monomer feed ratios, temperature, and pH. Here we report for the first time, the enzyme catalyzed polymerization of pyrrole and EDOT at an elevated pH = 5. The polymer composition was determined using X-ray photoelectron spectroscopy. Spectroscopic characterization [UV-Vis, FTIR], thermal analysis, and electrical conductivity measurements for these complexes indicated the formation of stable conducting copolymers. C1 [Nagarajan, Ramaswamy] Univ Massachusetts, Ctr Adv Mat, Dept Plast Engn, Lowell, MA 01854 USA. [Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Dept Phys & Appl Phys, Lowell, MA 01854 USA. [Tewari, Arti] Northeastern Univ, Dept Biochem, Boston, MA 02115 USA. [Kokil, Akshay; Ravichandran, Sethumadhavan; Nagarajan, Subhalakshmi] Univ Massachusetts, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. [Bouldin, Ryan] Univ Massachusetts, Ctr Adv Mat, Dept Chem Engn, Lowell, MA 01854 USA. [Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Nagarajan, R (reprint author), Univ Massachusetts, Ctr Adv Mat, Dept Plast Engn, 1 Univ Ave, Lowell, MA 01854 USA. EM ramaswamy_nagarajan@uml.edu; jayant_kumar@uml.edu RI Kokil, Akshay/A-6886-2009 OI Kokil, Akshay/0000-0002-8295-2878 NR 32 TC 12 Z9 12 U1 1 U2 21 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1022-1352 J9 MACROMOL CHEM PHYS JI Macromol. Chem. Phys. PD JUL 15 PY 2010 VL 211 IS 14 BP 1610 EP 1617 DI 10.1002/macp.201000046 PG 8 WC Polymer Science SC Polymer Science GA 634IO UT WOS:000280574500010 ER PT J AU Vilensky, JA Gilman, S McCall, S AF Vilensky, Joel A. Gilman, Sid McCall, Sherman TI A Historical Analysis of the Relationship Between Encephalitis Lethargica and Postencephalitic Parkinsonism: A Complex Rather than a Direct Relationship SO MOVEMENT DISORDERS LA English DT Editorial Material DE epidemic encephalitis; von Economo's disease; encephalitic parkinsonism ID PERSIAN-GULF-WAR; EPIDEMIC ENCEPHALITIS; DISEASE; INFLUENZA; RECALL; ACCURACY; SEQUELAE; BIAS AB Postencephalitic parkinsonism has been considered unique among disorders with parkinsonian features because it is believed to have a unitary etiology associated with the virus that presumably caused encephalitis lethargica. Careful analysis of the historical record, however, suggests that this relationship is more complex than commonly perceived. In most cases, the diagnosis of acute encephalitis lethargica was made post hoc, and virtually any catarrh-like illness was considered to have represented encephalitis lethargica, often after an oral history-taking that was undoubtedly subject to patient recall and physician bias. Also, postencephalitic parkinsonism and oculogyric crises were not recognized as sequelae to encephalitis lethargica until well after other sequelae such as movement disorders and mental. disturbances had been identified (see previous paper). We suggest here that the relationship between encephalitis lethargica and postencephalitic parkinsonism is not simplistic, i.e., encephalitis lethargica was not solely responsible for the etiology of postencephalitic parkinsonism, thus aligning the latter with most other parkinsonian disorders that are now believed to have multiple causes. (C) 2010 Movement Disorder Society C1 [Vilensky, Joel A.] Indiana Univ, Sch Med, Dept Anat & Cell Biol, Ft Wayne, IN 46805 USA. [Gilman, Sid] Univ Michigan, Sch Med, Dept Neurol, Ann Arbor, MI USA. [McCall, Sherman] USA, Med Res Inst Infect Dis, Dept Clin Pathol, Ft Detrick, MD 21702 USA. RP Vilensky, JA (reprint author), Indiana Univ, Sch Med, Dept Anat & Cell Biol, 2101 E Coliseum Blvd, Ft Wayne, IN 46805 USA. EM vilensk@ipfw.edu NR 76 TC 9 Z9 10 U1 1 U2 1 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0885-3185 J9 MOVEMENT DISORD JI Mov. Disord. PD JUL 15 PY 2010 VL 25 IS 9 BP 1116 EP 1123 DI 10.1002/mds.22908 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA 636YN UT WOS:000280781500002 PM 20629120 ER PT J AU Vilensky, JA Gilman, S McCall, S AF Vilensky, Joel A. Gilman, Sid McCall, Sherman TI Does the Historical Literature on Encephalitis Lethargica Support a Simple (Direct) Relationship with Postencephalitic Parkinsonism? SO MOVEMENT DISORDERS LA English DT Editorial Material DE epidemic encephalitis; von Economo's disease; encephalitic Parkinsonism; oculogyric crises ID CHRONIC EPIDEMIC ENCEPHALITIS; OCULOGYRIC CRISES; CONJUGATE; EYES AB This article and the subsequent one suggest that the currently accepted view of a simplistic (direct) relationship between encephalitis lethargica (EL) and postencephalitic Parkinsonism (PEP) is based on a incomplete evaluation of the epidemic period literature. In this article we provide a detailed analysis of the literature from the period that demonstrates that Parkinsonism was not initially part of acute EL symptomatology, that PEP was not typically the prevailing type of chronic EL and that oculogyric crises were never part of acute EL symptomatology and not initially associated with PEP. The second paper uses these finding, and also examines the clinical justifications for concluding that all patients with PEP had prior acute episodes of EL, to reevaluate the presumed direct etiologic relationship between EL and PEP. (C) 2010 Movement Disorder Society C1 [Vilensky, Joel A.] Indiana Univ, Sch Med, Dept Anat & Cell Biol, Ft Wayne, IN 46805 USA. [Gilman, Sid] Univ Michigan, Sch Med, Dept Neurol, Ann Arbor, MI USA. [McCall, Sherman] USA, Med Res Inst Infect Dis, Dept Clin Pathol, Ft Detrick, MD 21702 USA. RP Vilensky, JA (reprint author), Indiana Univ, Sch Med, Dept Anat & Cell Biol, 2101 E Coliseum Blvd, Ft Wayne, IN 46805 USA. EM vilensk@ipfw.edu NR 68 TC 8 Z9 8 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0885-3185 J9 MOVEMENT DISORD JI Mov. Disord. PD JUL 15 PY 2010 VL 25 IS 9 BP 1124 EP 1130 DI 10.1002/mds.22991 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA 636YN UT WOS:000280781500003 PM 20629127 ER PT J AU Shackman, AJ McMenamin, BW Maxwell, JS Greischar, LL Davidson, RJ AF Shackman, Alexander J. McMenamin, Brenton W. Maxwell, Jeffrey S. Greischar, Lawrence L. Davidson, Richard J. TI Identifying robust and sensitive frequency bands for interrogating neural oscillations SO NEUROIMAGE LA English DT Article ID INDEPENDENT COMPONENT ANALYSIS; MIDLINE THETA-RHYTHM; EVENT-RELATED POTENTIALS; FRONTAL BRAIN ASYMMETRY; DEFAULT MODE NETWORK; WORKING-MEMORY TASK; PRINCIPAL-COMPONENTS; EEG-ALPHA; AFFECTIVE STYLE; ELECTROENCEPHALOGRAPHIC ACTIVITY AB Recent years have seen an explosion of interest in using neural oscillations to characterize the mechanisms supporting cognition and emotion. Oftentimes, oscillatory activity is indexed by mean power density in predefined frequency bands. Some investigators use broad bands originally defined by prominent surface features of the spectrum. Others rely on narrower bands originally defined by spectral factor analysis (SPA). Presently, the robustness and sensitivity of these competing band definitions remains unclear. Here, a Monte Carlo-based SPA strategy was used to decompose the tonic ("resting" or "spontaneous") electroencephalogram (EEG) into five bands: delta (1-5 Hz), alpha-low (6-9 Hz), alpha-high ( 10-11 Hz), beta (12-19 Hz), and gamma (>21 Hz). This pattern was consistent across SPA methods, artifact correction/rejection procedures, scalp regions, and samples. Subsequent analyses revealed that SFA failed to deliver enhanced sensitivity: narrow alpha sub-bands proved no more sensitive than the classical broadband to individual differences in temperament or mean differences in task-induced activation. Other analyses suggested that residual ocular and muscular artifact was the dominant source of activity during quiescence in the delta and gamma bands. This was observed following threshold-based artifact rejection or independent component analysis (ICA)-based artifact correction, indicating that such procedures do not necessarily confer adequate protection. Collectively, these findings highlight the limitations of several commonly used EEG procedures and underscore the necessity of routinely performing exploratory data analyses, particularly data visualization, prior to hypothesis testing. They also suggest the potential benefits of using techniques other than SFA for interrogating high-dimensional EEG datasets in the frequency or time-frequency (event-related spectral perturbation, event-related synchronization/desynchronization) domains. (C) 2010 Elsevier Inc. All rights reserved. C1 [Shackman, Alexander J.] Univ Wisconsin, Dept Psychol, Wisconsin Psychiat Inst & Clin, Madison, WI 53706 USA. [Shackman, Alexander J.] Univ Wisconsin, Dept Psychiat, Wisconsin Psychiat Inst & Clin, Madison, WI 53706 USA. [McMenamin, Brenton W.] Univ Minnesota, Ctr Cognit Sci, St Paul, MN USA. [McMenamin, Brenton W.] Univ Minnesota, Dept Psychol, St Paul, MN USA. [Maxwell, Jeffrey S.] USA, Res Lab, Aberdeen, MD USA. [Davidson, Richard J.] Univ Wisconsin, Lab Affect Neurosci, Waisman Lab Brain Imaging & Behav, HealthEmot Res Inst, Madison, WI 53706 USA. [Davidson, Richard J.] Univ Wisconsin, Ctr Investigating Healthy Minds, Dept Psychol, Madison, WI 53706 USA. [Davidson, Richard J.] Univ Wisconsin, Ctr Investigating Healthy Minds, Dept Psychiat, Madison, WI 53706 USA. RP Shackman, AJ (reprint author), Univ Wisconsin, Dept Psychol, Wisconsin Psychiat Inst & Clin, 1202 W Johnson St, Madison, WI 53706 USA. EM shackman@wisc.edu; mcmen020@umn.edu; rjdavids@wisc.edu RI Shackman, Alexander/B-3458-2009; OI Shackman, Alexander/0000-0002-3629-4704 FU NIMH [P50-MH52354, MH43454]; NIH [T32-HD007151] FX The first two authors contributed equally to this study. We thank Donna Cole, Isa Dolski, Andrew Fox, Aaron Heller, Laura Friedman, Donald McLaren, Bradley Postle, Jessica Shackman, Jonathan Shackman, Aaron Teche, Barry Van Veen, and three anonymous reviewers for assistance and NIMH (P50-MH52354 and MH43454 to RJD) for support. BM was supported by NIH T32-HD007151. Authors acknowledge no conflicts of interest. NR 177 TC 38 Z9 38 U1 15 U2 32 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 J9 NEUROIMAGE JI Neuroimage PD JUL 15 PY 2010 VL 51 IS 4 BP 1319 EP 1333 DI 10.1016/j.neuroimage.2010.03.037 PG 15 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 601EV UT WOS:000278042000005 PM 20304076 ER PT J AU Edwards, J Simmons, E Cordero, S Lieuw, K Roberts, S AF Edwards, Jeremy Simmons, Elizabeth Cordero, Steve Lieuw, Kenneth Roberts, Stephen TI Retinal Hemorrhages as a Presenting Sign in an Adolescent Patient With Hepatosplenic Gamma-Delta T-cell Lymphoma SO PEDIATRIC BLOOD & CANCER LA English DT Article DE adolescent; gamma-delta T-cell lymphoma; retinal hemorrhage ID CLINICOPATHOLOGICAL ENTITY; HEMOPHAGOCYTIC SYNDROME; DISEASE AB Hepatosplenic gamma-delta T-cell lymphoma is a very rare, aggressive form of peripheral lymphoma first recognized in 1990. Patients often present with organomegaly, anemia, adenopathy, and B symptoms. Rarely in the literature is a pediatric patient described with this subtype of peripheral T-cell lymphoma. Also, retinal hemorrhages have never been described as a presenting symptom of hepatosplenic gamma-delta T-cell lymphoma. We describe an adolescent patient with hepatosplenic gamma delta T-cell lymphoma who presented with retinal hemorrhages, massive splenomegaly, bone marrow involvement, and B Pediatr Blood Cancer 2010;55:190-192. (C) 2010 Wiley-Liss, Inc. C1 [Edwards, Jeremy] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Simmons, Elizabeth; Lieuw, Kenneth; Roberts, Stephen] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Cordero, Steve] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. RP Edwards, J (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM jeremy.v.edwards@us.army.mil NR 20 TC 0 Z9 1 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1545-5009 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD JUL 15 PY 2010 VL 55 IS 1 BP 190 EP 192 DI 10.1002/pbc.22485 PG 3 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 601BJ UT WOS:000278032700042 PM 20486185 ER PT J AU Rocheleau, S Kuperrnan, RG Simini, M Hawari, J Checkai, RT Thiboutot, S Ampleman, G Sunahara, GI AF Rocheleau, Sylvie Kuperrnan, Roman G. Simini, Mike Hawari, Jalal Checkai, Ronald T. Thiboutot, Sonia Ampleman, Guy Sunahara, Geoffrey I. TI Toxicity of 2,4-dinitrotoluene to terrestrial plants in natural soils SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE 2,4-DNT; Plant toxicity; Bioavailability; Natural soils ID NITROAROMATIC COMPOUNDS; ENERGETIC COMPOUNDS; PHYTOTOXICITY AB The presence of energetic materials (used as explosives and propellants) at contaminated sites is a growing international issue, particularly with respect to military base closures and demilitarization policies. Improved understanding of the ecotoxicological effects of these materials is needed in order to accurately assess the potential exposure risks and impacts on the environment and its ecosystems. We studied the toxicity of the nitroaromatic energetic material 2,4-dinitrotoluene (2,4-DNT) on alfalfa (Medicago sativa L.), barnyard grass (Echinochloa crusgalli L. Beauv.), and perennial ryegrass (Lolium perenne L.) using four natural soils varying in properties (organic matter, clay content, and pH) that were hypothesized to affect chemical bioavailability and toxicity. Amended soils were subjected to natural light conditions, and wetting and drying cycles in a greenhouse for 13 weeks prior to toxicity testing to approximate field exposure conditions in terms of bioavailability, transformation, and degradation of 2,4-DNT. Definitive toxicity tests were performed according to standard protocols. The median effective concentration (EC(50)) values for shoot dry mass ranged from 8 to 229 mg kg(-1), depending on the plant species and soil type. Data indicated that 2,4-DNT was most toxic in the Sassafras (SSL) and Teller (TSL) sandy loam soils, with EC(50) values for shoot dry mass ranging between 8 to 44 mg kg(-1), and least toxic in the Webster clay loam soil, with EC(50) values for shoot dry mass ranging between 40 to 229 mg kg(-1). The toxicity of 2,4-DNT for each of the plant species was significantly (p <= 0.05) and inversely correlated with the soil organic matter content. Toxicity benchmark values determined in the present studies for 2,4-DNT weathered-and-aged in SSL or TSL soils will contribute to development of an Ecological Soil Screening Level for terrestrial plants that can be used for ecological risk assessment at contaminated sites. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved. C1 [Rocheleau, Sylvie; Hawari, Jalal; Sunahara, Geoffrey I.] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada. [Kuperrnan, Roman G.; Simini, Mike; Checkai, Ronald T.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Thiboutot, Sonia; Ampleman, Guy] Def Res & Dev Canada Valcartier, Quebec City, PQ G3J 1X5, Canada. RP Sunahara, GI (reprint author), Natl Res Council Canada, Biotechnol Res Inst, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, Canada. EM geoffrey.sunahara@cnrc-nrc.gc.ca RI Kuperman, Roman/D-4297-2009; OI Kuperman, Roman/0000-0001-5344-1633 FU U.S. Department of Defense [ER-1416] FX This research was supported by the U.S. Department of Defense through the Strategic Environmental Research and Development Program (SERDP Project ER-1416). Special thanks go to Catherine Dimacacos, Alain Corriveau, Louise Paquet, Sabine Dodard, Manon Sarrazin, and Kathleen Savard for their technical support. This publication was assigned the National Research Council number 50015. NR 31 TC 7 Z9 7 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD JUL 15 PY 2010 VL 408 IS 16 BP 3193 EP 3199 DI 10.1016/j.scitotenv.2010.04.010 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 623VM UT WOS:000279773200019 PM 20471667 ER PT J AU Sclafani, JJ My, J Zacher, LL Eckart, RE AF Sclafani, Joseph J. My, Joseph Zacher, Lisa L. Eckart, Robert E. TI Intensive Education on Evidence-Based Evaluation of Syncope Increases Sudden Death Risk Stratification but Fails to Reduce Use of Neuroimaging SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID GENERAL HOSPITALS; UNEXPLAINED SYNCOPE; DIAGNOSING SYNCOPE; MANAGEMENT; YIELD; DISEASE; UNITS; CARE AB Background: We sought to determine whether aggressive education on evidence-based guidelines would affect the use of resources. Specifically, we sought to educate providers about the role of neuroimaging as well as sudden death risk stratification. Methods: We reviewed 1092 consecutive cases involving patients who were admitted for syncope. We retrospectively reviewed 30 months of admissions for baseline characteristics and then initiated an intensive monthly education campaign directed toward internal medicine physicians-in-training focusing on evidence-based guidelines for a 13-month period. Results: There were 721 patients (66.0%) evaluated before the education intervention and 371 patients (34.0%) evaluated after the education intervention. After the intervention, there was no change in the use of computed tomography (52.3% vs 55.5%; P = .31) or magnetic resonance imaging (20.2% vs 16.7%; P = .16) of the head or carotid ultrasonography (4.7% vs 6.2%; P = .30). The re-ferral rate for electrophysiologic study significantly increased from 6.4% at baseline to 11.3% (P = .006) after intervention, with an overall diagnostic yield of 28.4%. Of those with identified structural heart disease, the referral rate went from 5.7% to 19.0% (P = .03). Only 66 of 1092 patients who presented with syncope ultimately required a pacemaker or defibrillator implantation during hospitalization. Conclusions: With intensive education, there was no decrease in neuroimaging, despite a low diagnostic yield. We were able to increase sudden death risk stratification using electrophysiologic studies without evidence of overuse of implantable device-based therapy. Intensive education allows increased adherence to guidelines for mortality reduction; however, further attempts to reduce the lower yield imaging will require methods other than education of hospital-based physicians. C1 [Sclafani, Joseph J.; My, Joseph; Zacher, Lisa L.; Eckart, Robert E.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. RP Sclafani, JJ (reprint author), Brooke Army Med Ctr, Dept Med MCHE M DC, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM joseph.sclafani@amedd.army.mil NR 31 TC 6 Z9 6 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD JUL 12 PY 2010 VL 170 IS 13 BP 1150 EP 1154 DI 10.1001/archinternmed.2010.205 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 624DY UT WOS:000279797700013 PM 20625024 ER PT J AU Casares, S Brumeanu, TD Richie, TL AF Casares, Sofia Brumeanu, Teodor-Doru Richie, Thomas L. TI The RTS,S malaria vaccine SO VACCINE LA English DT Review DE RTS,S; Malaria vaccine development; Immunology ID FALCIPARUM CIRCUMSPOROZOITE-PROTEIN; RANDOMIZED CONTROLLED-TRIAL; PRIME-BOOST IMMUNIZATION; B SURFACE-ANTIGEN; T-CELL RESPONSES; PHASE 2A TRIAL; PLASMODIUM-FALCIPARUM; PROTECTIVE IMMUNITY; NAIVE ADULTS; MOZAMBICAN CHILDREN AB RTS,S is the most advanced candidate vaccine against human malaria. During its remarkable journey from conception and design in the early 1980s to the multicenter Phase 3 trial currently underway across sub-Saharan Africa, RTS,S has overcome tremendous challenges and disproved established vaccine paradigms. In the last several years, Phase 2 studies conducted in infants and children in endemic areas have established the efficacy of RTS,S for reducing morbidity due to clinical malaria. If the results are realized in the Phase 3 trial, the chances for licensure in the near future appear high. Such progress is all the more remarkable given our lack of clear understanding regarding how the vaccine activates the human immune system, the immune correlates of protection or the mechanism whereby a vaccine targeting sporozoites and liver stage parasites can reduce the clinical disease associated with parasitemia. These unanswered questions pose important challenges to be addressed in the quest to understand the protection afforded by RTS,S and to build a more efficacious second generation vaccine against malaria. This review will focus on current knowledge about the protective efficacy of RTS,S and what we have learned regarding its impact on the human immune system. Published by Elsevier Ltd. C1 [Casares, Sofia; Richie, Thomas L.] Walter Reed Army Inst Res, Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Casares, Sofia; Brumeanu, Teodor-Doru] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Casares, S (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM sofia.casares@med.navy.mil OI Richie, Thomas/0000-0002-2946-5456 FU [6000.RAD1.F.] FX We gratefully acknowledge PLoS ONE for allowing us to republish Fig. 3. We are also most appreciative of the assistance provided by Vasee Moorthy and Ripley Ballou in reviewing the entire manuscript and Box 1, respectively. The assistance from these individuals should not be construed as an endorsement of the views expressed in this article. The views expressed are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the US Government. The study protocols for the clinical trials discussed in this manuscript that were performed by the US Navy or US Army were approved by the Naval Medical Research Center or Walter Reed Army Institute of Research Institutional Review Boards, respectively, in compliance with all applicable Federal regulations governing the protection of human subjects. Likewise, the animal experiments reported herein that were conducted by the US Navy or US Army were conducted in compliance with the Animal Welfare Act and in accordance with the principles set forth in the "Guide for the Care and Use of Laboratory Animals", Institute of Laboratory Animals Resources, National Research Council, National Academy Press, 1996. TLR is a military service member and SC and TDB are US Government employees. The work of SC, TDB and TLR was prepared as part of official government duties. Title 17 U.S.C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government'. Title 17 U.S.C. 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. The work was supported by work unit number 6000.RAD1.F. NR 80 TC 66 Z9 66 U1 1 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 12 PY 2010 VL 28 IS 31 BP 4880 EP 4894 DI 10.1016/j.vaccine.2010.05.033 PG 15 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 635MK UT WOS:000280659600007 PM 20553771 ER PT J AU Cummings, JF Spring, MD Schwenk, RJ Ockenhouse, CF Kester, KE Polhemus, ME Walsh, DS Yoon, IK Prosperi, C Juompan, LY Lanar, DE Krzych, U Hall, BT Ware, LA Stewart, VA Williams, J Dowler, M Nielsen, RK Hillier, CJ Giersing, BK Dubovsky, F Malkin, E Tucker, K Dubois, MC Cohen, JD Ballou, WR Heppner, DG AF Cummings, James F. Spring, Michele D. Schwenk, Robert J. Ockenhouse, Christian F. Kester, Kent E. Polhemus, Mark E. Walsh, Douglas S. Yoon, In-Kyu Prosperi, Christine Juompan, Laure Y. Lanar, David E. Krzych, Urszula Hall, B. Ted Ware, Lisa A. Stewart, V. Ann Williams, Jack Dowler, Megan Nielsen, Robin K. Hillier, Collette J. Giersing, Birgitte K. Dubovsky, Filip Malkin, Elissa Tucker, Kathryn Dubois, Marie-Claude Cohen, Joe D. Ballou, W. Ripley Heppner, D. Gray, Jr. TI Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+T cells but does not protect against experimental Plasmodium falciparum infection SO VACCINE LA English DT Article DE Malaria vaccine; Plasmodium falciparum; Liver Stage Antigen ID GAMMA-INTERFERON RESPONSES; T-CELL; MALARIA VACCINE; ADJUVANT AS01B; B-CELL; IMMUNOGENICITY; RESISTANCE; IMMUNITY; INTERLEUKIN-10; PEPTIDE AB Plasmodium falciparum Liver Stage Antigen 1 (LSA-1) is a pre-erythrocytic stage antigen. Our LSA-1 vaccine candidate is a recombinant protein with full-length C- and N-terminal flanking domains and two of the 17 amino acid repeats from the central repeat region termed "LSA-NRC." We describe the first Phase I/II study of this recombinant LSA-NRC protein formulated with either the AS01 or AS02 adjuvant system. We conducted an open-label Phase I/II study. Thirty-six healthy malaria-naive adults received one of four formulations by intra-deltoid injection on a 0 and 1 month schedule; low dose (LD)LSA-NRC/AS01:10 mu g LSA-NRC/0.5 ml AS01 (n = 5), high dose (HD) LSA-NRC/AS01: 50 p,g LSA-NRC/0.5 ml AS01 (n = 13); LD LSA-NRC/AS02: 10 mu g LSA-NRC/0.5 ml AS02 (n = 5) and HD LSA-NRC/AS02: 50 u4 LSA-NRC/0.5 ml AS02 (n = 13). Two weeks post-second immunization, the high dose vaccinees and 6 non-immunized infectivity controls underwent experimental malaria sporozoite challenge. The vaccines showed a reassuring safety profile but were moderately reactogenic. There were no serious adverse events. All subjects seroconverted after the first immunization. Following the second immunization, LSA-1-specific CD4+ T cells producing two cytokines (IL-2 and IFN-gamma) were found by intra-cellular staining in all subjects in the LD LSA-NRC/AS01B group and in 3 of 5 subjects in the LD LSA-NRC/AS02 group. In contrast, the HD LSA-NRC/AS01 and HD LSA-NRC/AS02 group subjects had fewer LSA-1-specific CD4+ T cells, and minimal to no IFN-gamma responses. There was no increase in LSA-1-specific CD8+ T cells found in any group. Per protocol, 22 high dose vaccinees, but no low dose vaccinees, underwent P. falciparum homologous malaria challenge (307 clone). All vaccinees became parasitemic and there was no delay in their pre-patent period versus controls (p = 0.95). LSA-NRC/AS01 and LSA-NRC/AS02 elicited antigen-specific antibody and CD4+ T cell responses, but elicited no protective immunity. Although the optimal antigen dose of LSA-NRC may not have been selected for the challenge portion of the protocol, further vaccine development based upon LSA-1 should not be excluded and should include alternative vaccine platforms able to elicit additional effector mechanisms such as CD8+ T cells. (C) 2009 Published by Elsevier Ltd. C1 [Cummings, James F.] Walter Reed Army Inst Res, Dept Clin Trials, Silver Spring, MD 20910 USA. [Giersing, Birgitte K.; Dubovsky, Filip; Malkin, Elissa] PATH Malaria Vaccine Initiat MVI, Bethesda, MD USA. [Tucker, Kathryn] Stat Collaborat Inc, Washington, DC USA. [Dubois, Marie-Claude; Cohen, Joe D.; Ballou, W. Ripley] GlaxoSmithKline Biol, Rixensart, Belgium. RP Cummings, JF (reprint author), Walter Reed Army Inst Res, Dept Clin Trials, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM james.cummings@us.army.mil; dwalsh@wrp-ksm.org; InkyuYoon@afrims.org; astewart@wrp-ksm.org; Chillier@arana.com; giersingb@ebsi.com; dubovskyf@medimmune.com; malkine@medimmune.com; rip.ballou@gatesfoundation.org; donald.heppner@us.army.mil RI Kester, Kent/A-2114-2011; Lanar, David/B-3560-2011; Nielsen, Robin/B-6811-2011 OI Kester, Kent/0000-0002-5056-0802; FU PATH Malaria Vaccine Initiative, Bethesda, Maryland; Military Infectious Disease Research Program, Fort Detrick, Maryland FX The cGMP manufacture of LSA-NRC and this trial were funded by the PATH Malaria Vaccine Initiative, Bethesda, Maryland and by the Military Infectious Disease Research Program, Fort Detrick, Maryland. Conflict of interest: J.D. Cohen, W.R. Ballou, M.C. Dubois were employees of and owned stock in GSK Biologicals, the manufacturer of the described Adjuvant Systems when this study was planned and conducted. D.E. Lanar and L.A. Ware have applied for patents involving the described vaccine antigen, LSA-NRC. J.D. Cohen, W.R. Ballou, V.A. Stewart, C.F. Ockenhouse and D.G. Heppner are listed as inventors on patents or have patent applications covering various malaria vaccine candidates. Disclosure: Presented in part at the 55th annual meeting of the American Society of Tropical Medicine and Hygiene held in Atlanta, Georgia, 12-16 November 2006. NR 37 TC 36 Z9 37 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 12 PY 2010 VL 28 IS 31 BP 5135 EP 5144 DI 10.1016/j.vaccine.2009.08.046 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 635MK UT WOS:000280659600038 PM 19737527 ER PT J AU Blenner, MA Shur, O Szilvay, GR Cropek, DM Banta, S AF Blenner, Mark A. Shur, Oren Szilvay, Geza R. Cropek, Donald M. Banta, Scott TI Calcium-Induced Folding of a Beta Roll Motif Requires C-Terminal Entropic Stabilization SO JOURNAL OF MOLECULAR BIOLOGY LA English DT Article DE beta roll; repeat folding; capping domains; calcium-induced folding; protein switch ID LEUCINE-RICH REPEAT; ADENYLATE-CYCLASE TOXIN; ANTI-SIGMA FACTOR; CRYSTAL-STRUCTURE; SERRATIA-MARCESCENS; PROTEIN SECONDARY; BINDING PROTEIN; TPR MOTIF; DESIGN; CONSENSUS AB Beta roll motifs are associated with several proteins secreted by the type 1 secretion system (T1SS). Located just upstream of the C-terminal T1SS secretion signal, they are believed to act as calcium-induced switches that prevent folding before secretion. Bordetella pertussis adenylate cyclase (CyaA) toxin has five blocks of beta roll motifs (or repeats-in-toxin motifs) separated by linkers. The block V motif on its own has been reported to be non-responsive to calcium. Only when the N- and C-terminal linkers, or flanking groups, were fused did the motif bind calcium and fold. In an effort to understand the requirements for beta roll folding, we have truncated the N- and C-terminal flanks at several locations to determine the minimal essential sequences. Calcium-responsive beta roll folding occurred even in the absence of the natural N-terminal flank. The natural C-terminal flank could not be truncated without decreased calcium affinity and only partially truncated before losing calcium-responsiveness. Globular protein fusion at the C-terminus likewise enabled calcium-induced folding but fusions solely at the N-terminus failed. This demonstrates that calcium-induced folding is an inherent property of the beta roll motif rather than the flanking groups. Given the disparate nature of the observed functional flanking groups, C-terminal fusions appear to confer calcium-responsiveness to the beta roll motif via a nonspecific mechanism, suggesting that entropic stabilization of the unstructured C-terminus can enable beta roll folding. Increased calcium affinity was observed when the natural C-terminal flank was used to enable calcium-induced folding, pointing to its cooperative participation in beta roll formation. This work indicates that a general principle of C-terminal entropic stabilization can enable stimulus-responsive repeat protein folding, while the C-terminal flank has a specific role in tuning calcium-responsive beta roll formation. These observations are in stark contrast to what has been reported for other repeat proteins. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Blenner, Mark A.; Shur, Oren; Szilvay, Geza R.; Banta, Scott] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. [Cropek, Donald M.] USA, Engineer Res & Dev Ctr, CERL, Champaign, IL 61822 USA. RP Banta, S (reprint author), Columbia Univ, Dept Chem Engn, 500 W 120th St, New York, NY 10027 USA. EM sbanta@columbia.edu RI Szilvay, Geza/G-3025-2014 OI Szilvay, Geza/0000-0002-2718-751X FU Defense Threat Reduction Agency; US Army [6.1]; Academy of Finland; Alfred Kordelin Foundation FX We greatly appreciate the gift of plasmid pDLE9-CyaA used to construct various RTX molecules provided by Dr Daniel Ladant (Institute Pasteur, France). We thank Carol Li for technical help. This work was funded by the Defense Threat Reduction Agency (SB/DMC), US Army 6.1 (SB/DMC), the Academy of Finland (GSz), and the Alfred Kordelin Foundation (GSz). NR 49 TC 25 Z9 25 U1 0 U2 4 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-2836 J9 J MOL BIOL JI J. Mol. Biol. PD JUL 9 PY 2010 VL 400 IS 2 BP 244 EP 256 DI 10.1016/j.jmb.2010.04.056 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 623ZW UT WOS:000279786900011 PM 20438736 ER PT J AU Owens, BD Nelson, BJ Duffey, ML Mountcastle, SB Taylor, DC Cameron, KL Campbell, S DeBerardino, TM AF Owens, Brett D. Nelson, Bradley J. Duffey, Michele L. Mountcastle, Sally B. Taylor, Dean C. Cameron, Kenneth L. Campbell, Scot DeBerardino, Thomas M. TI Pathoanatomy of First-Time, Traumatic, Anterior Glenohumeral Subluxation Events SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID MR ARTHROGRAPHY; SHOULDER INSTABILITY; DISLOCATIONS; ACCURACY; INJURIES AB Background: Relative to dislocations, glenohumeral subluxation events have received little attention in the literature, despite a high incidence in young athletes. The pathoanatomy of first-time, traumatic, anterior subluxation events has not been defined, to our knowledge. Methods: As part of a prospective evaluation of all cases of shoulder instability sustained during one academic year in a closed cohort of military academy cadets, a total of thirty-eight first-time, traumatic, anterior glenohumeral subluxation events were documented. Clinical subluxation events were defined as incomplete instability events that did not require a manual reduction maneuver. Twenty-seven of those events were evaluated with plain radiographs and magnetic resonance imaging within two weeks after the injury and constitute the cohort studied. Magnetic resonance imaging studies were independently evaluated by a musculoskeletal radiologist blinded to the clinical history. Arthroscopic findings were available for the fourteen patients who underwent arthroscopic surgery. Results: Of the twenty-seven patients who sustained a first-time, traumatic, anterior subluxation, twenty-two were male and five were female, and their mean age was twenty years. Plain radiographs revealed three osseous Bankart lesions and two Hill-Sachs lesions. Magnetic resonance imaging revealed a Bankart lesion in twenty-six of the twenty-seven patients and a Hill-Sachs lesion in twenty-five of the twenty-seven patients. Of the fourteen patients who underwent surgery, thirteen had a Bankart lesion noted during the procedure. Of the thirteen patients who chose nonoperative management, four experienced recurrent instability. Two of the thirteen patients left the academy for nonmedical reasons and were lost to follow-up. The remaining seven patients continued on active-duty service and had not sought care for a recurrent instability event at the time of writing. Conclusions: First-time, traumatic, anterior subluxation events result in a high rate of labral and Hill-Sachs lesions. These findings suggest that clinical subluxation events encompass a broad spectrum of incomplete events, including complete separations of the articular surfaces with spontaneous reduction. A high index of suspicion for this injury in young athletes is warranted, and magnetic resonance imaging may reveal a high rate of pathologic changes, suggesting that a complete, transient luxation of the glenohumeral joint has occurred. C1 [Owens, Brett D.; Cameron, Kenneth L.] Keller Army Hosp, US Mil Acad, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Hosp, US Mil Acad, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil OI DeBerardino, Thomas/0000-0002-7110-8743; Cameron, Kenneth/0000-0002-6276-4482 NR 21 TC 31 Z9 35 U1 2 U2 5 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD JUL 7 PY 2010 VL 92A IS 7 BP 1605 EP 1611 DI 10.2106/JBJS.I.00851 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 618QB UT WOS:000279369700005 PM 20595566 ER PT J AU Xu, K von Cresce, A Lee, U AF Xu, Kang von Cresce, Arthur Lee, Unchul TI Differentiating Contributions to "Ion Transfer" Barrier from Interphasial Resistance and Li+ Desolvation at Electrolyte/Graphite Interface SO LANGMUIR LA English DT Article ID IONIZATION-MASS-SPECTROSCOPY; LIBOB-BASED ELECTROLYTES; LITHIUM-ION; GRAPHITE/ELECTROLYTE INTERFACE; NONAQUEOUS ELECTROLYTES; SOLVATION SHEATH; CARBON ANODES; BATTERIES; CHEMISTRY; GRAPHITE AB Efforts were made to differentiate the contributions to the so-called ''ion transfer" barrier at the electrolyte/graphite junction from two distinct processes: (1) desolvation of Li+ before it enters graphene interlayer and (2) the subsequent migration of bare Li+ through the ad hoc interphase. By leveraging a scenario where no substantial interphase was formed on Li+ intercalation hosts, we were able to quantity the distribution of "ion transfer" activation energy between these two interfacial processes and hence identify the desolvation process of Li+ as the major energy-consuming step. The result confirmed the earlier belief that the rate-determining step in the charging of a graphitic anode in Li+ in chemistry relates to the stripping of salvation sheath of Li+, which is closely interwoven with the interphasial resistance to Li+ migration. C1 [Xu, Kang; von Cresce, Arthur] US Army Res Lab, Power & Energy Div, Electrochem Branch, Adelphi, MD 20783 USA. [Lee, Unchul] US Army Res Lab, Infrared Mat Branch, Electroopt & Photon Div, Sensor & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Xu, K (reprint author), US Army Res Lab, Power & Energy Div, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM cxu@arl.army.mil RI Cresce, Arthur/K-3958-2013 OI Cresce, Arthur/0000-0002-3894-6083 FU US Department of Energy FX This work was partially funded by Advanced Battery Research Technology (ABRT) Program of the US Department of Energy with cost shared by the U.S. Army Research Laboratory. NR 26 TC 70 Z9 70 U1 7 U2 77 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD JUL 6 PY 2010 VL 26 IS 13 BP 11538 EP 11543 DI 10.1021/la1009994 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 616VX UT WOS:000279239900155 PM 20446717 ER PT J AU Guglielmone, AA Robbins, RG Apanaskevich, DA Petney, TN Estrada-Pena, A Horak, IG Shao, RF Barker, SC AF Guglielmone, Alberto A. Robbins, Richard G. Apanaskevich, Dmitry A. Petney, Trevor N. Estrada-Pena, Agustin Horak, Ivan G. Shao, Renfu Barker, Stephen C. TI The Argasidae, Ixodidae and Nuttalliellidae (Acari: Ixodida) of the world: a list of valid species names SO ZOOTAXA LA English DT Article DE Acari; Argasidae; Ixodidae; Nuttalliellidae; species list ID GENUS HYALOMMA; TICKS ACARI; SYSTEMATICS; PHYLOGENY; EVOLUTION; NEUMANN; KOCH AB This work is intended as a consensus list of valid tick names, following recent revisionary studies, wherein we recognize 896 species of ticks in 3 families. The Nuttalliellidae is monotypic, containing the single entity Nuttalliella namaqua. The Argasidae consists of 193 species, but there is widespread disagreement concerning the genera in this family, and fully 133 argasids will have to be further studied before any consensus can be reached on the issue of genus-level classification. The Ixodidae comprises 702 species in 14 genera: Amblyomma (130 species, of which 17 were formerly included in Aponomma, a genus that is still considered valid by some authors), Anomalohimalaya (3), Bothriocroton (7, all previously included in Aponomma), Cosmiomma (1), Cornupalpatum (1), Compluriscutula (1), Dermacentor (34, including the single member of the former genus Anocentor, which is still considered valid by some authors), Haemaphysalis (166), Hyalomma (27), Ixodes (243), Margaropus (3), Nosomma (2), Rhipicentor (2) and Rhipicephalus (82, including 5 species from the former genus Boophilus, which is still considered valid by some authors). We regard six names as invalid: Amblyomma laticaudae Warburton, 1933 is a synonym of Amblyomma nitidum Hirst & Hirst, 1910; Bothriocroton decorosum (Koch, 1867) is a synonym of B. undatum (Fabricius, 1775); Haemaphysalis vietnamensis Hoogstraal & Wilson, 1966 is a synonym of H. colasbelcouri (Santos Dias, 1958); Haemaphysalis xinjiangensis Teng, 1980 is a synonym of H. danieli Cerny & Hoogstraal, 1977; Hyalomma erythraeum Tonelli-Rondelli, 1932 is a synonym of H. impeltatum Schulze and Schlottke, 1930 and Rhipicephalus hoogstraali Kolonin, 2009 was not described according to the rules of the International Code of Zoological Nomenclature. C1 [Guglielmone, Alberto A.] Inst Nacl Tecnol Agropecuaria, Estn Expt Agropecuaria Rafaela, Agropecuaria, Argentina. [Robbins, Richard G.] Walter Reed Army Med Ctr, ISD AFPMB, Washington, DC 20307 USA. [Apanaskevich, Dmitry A.] Georgia So Univ, US Natl Tick Collect, Jr Inst Arthropodol & Parasitol, Statesboro, GA 30460 USA. [Petney, Trevor N.] Zool Inst I, Abt Okol & Parasitol, D-76131 Karlsruhe, Germany. [Estrada-Pena, Agustin] Univ Zaragoza, Fac Vet, E-50013 Zaragoza, Spain. [Horak, Ivan G.] Univ Pretoria, Fac Vet Sci, Dept Vet Trop Dis, ZA-0110 Onderstepoort, South Africa. [Shao, Renfu; Barker, Stephen C.] Univ Queensland, Sch Mol & Microbiol Sci, Parasitol Sect, Brisbane, Qld 4072, Australia. RP Guglielmone, AA (reprint author), Inst Nacl Tecnol Agropecuaria, Estn Expt Agropecuaria Rafaela, Agropecuaria, Argentina. EM aguglielmone@rafaela.inta.gov.ar; richard.robbins@osd.mil; dapanaskevich@georgiasouthern.edu; Trevor.petney@t-online.de; aestrada@unizar.es; ivan.horak@up.ac.za; s.barker@uq.edu.au OI Estrada Pena, Agustin/0000-0001-7483-046X FU Argentinian and South African governments [SA 0805]; National Research Foundation of South Africa; Instituto Nacional de Tecnologia Agropecuaria (INTA); Asociacion Cooperadora de la Estacion Experimental Agropecuaria Rafaela de INTA; Consejo Nacional de Investigaciones Cientificas y Tecnicas (Argentina) FX We thank the Argentinian and South African governments, who supported part of this study within the framework of the bilateral cooperation project SA 0805. We are also grateful to the staff of the U. S. Library of Congress for their help in ascertaining the exact year of publication of some papers. This compilation was initiated under the auspices of the Integrated Consortium on Ticks and Tick-borne Diseases 3, and we appreciate the encouragement of Prof. F. Jongejan, Coordinator of the Consortium. We thank Marta Sanchez, the librarian of INTA Rafaela, for her assistance in searching the vast tick literature, along with Yago Alfonso from the Centro Argentino de Informacion Cientifica y Tecnica, and Margarida Santos Silva from Portugal who collaborated with AEP. Dr. Natal'ia A. Filippova, Zoological Institute, Russian Academy of Sciences, St. Petersburg, meticulously reviewed an earlier draft of this paper. The participation of IGH in this project was supported by the National Research Foundation of South Africa. Thanks also to the Instituto Nacional de Tecnologia Agropecuaria (INTA), the Asociacion Cooperadora de la Estacion Experimental Agropecuaria Rafaela de INTA, and the Consejo Nacional de Investigaciones Cientificas y Tecnicas (Argentina), for their support of AAG. NR 54 TC 131 Z9 149 U1 6 U2 12 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD JUL 6 PY 2010 IS 2528 BP 1 EP 28 PG 28 WC Zoology SC Zoology GA 620RJ UT WOS:000279516700001 ER PT J AU Jiang, JY Lima, OV Pei, Y Jiang, Z Chen, ZG Yu, CC Wang, J Zeng, XC Forsythe, E Tan, L AF Jiang, Jinyue Lima, Ocelio V. Pei, Yong Jiang, Zhang Chen, Ziguang Yu, Chichao Wang, Jin Zeng, Xiao Cheng Forsythe, Eric Tan, Li TI Self-Assembled Nano layers of Conjugated Si lane with pi-pi Interlocking SO ACS NANO LA English DT Article DE self-assembly; nanolayer; pi-pi interlocking; conjugation; silane ID MONOLAYERS; GOLD; GROWTH; TRANSISTORS; HYDROLYSIS; MOLECULES; SURFACES; FILM AB The packing of electronic molecules into planar structures and an ensured pi-pi interaction within the plane are preferred for efficient organic transistors. Thin films of organic electronics are exemplar, but the widely adopted molecular design and associated fabrication lead to limited ordering in multistack construction motifs. Here we demonstrate self-assembled nanolayers of organic molecules having potential electronic utility using an amphiphilic silane as a building block. Unlike a cross-linked (tetrahedral) configuration found in conventional siloxane networks, a linear polymer chain is produced following silane polycondensation. As a result, hydrophobic branches plus a noncovalent pi-pi interlocking between the molecules promote planar packing and continuous stacking along the surface normal. In contrast to conventional pi-pi stacking or hydrogen bonding pathways in a fibrous construct, multistacked nanolayers with coexisting pi-pi and herringbone interlocking can provide unmatched properties and processing convenience in molecular electronics. C1 [Jiang, Jinyue; Lima, Ocelio V.; Chen, Ziguang; Yu, Chichao; Tan, Li] Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA. [Jiang, Jinyue; Lima, Ocelio V.; Chen, Ziguang; Yu, Chichao; Tan, Li] Univ Nebraska, Nebraska Ctr Mat & Nanosci, Lincoln, NE 68588 USA. [Pei, Yong; Zeng, Xiao Cheng] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA. [Jiang, Zhang; Wang, Jin] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA. [Forsythe, Eric] USA, Res Lab, Flexible Display Ctr, Adelphi, MD 20783 USA. RP Tan, L (reprint author), Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA. EM Itan4@unl.edu RI Jiang, Zhang/A-3297-2012; Chen, Ziguang/B-8193-2012; Yu, Chichao/F-9423-2012; Pei, Yong/G-1564-2015 OI Jiang, Zhang/0000-0003-3503-8909; Chen, Ziguang/0000-0002-5773-9469; FU National Science Foundation [CMMI 0825905, CMMI 0900644] FX The authors thank Professor Patrick H. Dussault and his group members, as well as Mr. Alexandre Dhotel, for their generous help and gratefully acknowledge the partial financial support from the National Science Foundation (CMMI 0825905 and CMMI 0900644; Program Manager: Dr. Dwight Woolard). NR 39 TC 13 Z9 14 U1 4 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 J9 ACS NANO JI ACS Nano PD JUL PY 2010 VL 4 IS 7 BP 3773 EP 3780 DI 10.1021/nn100273m PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 631RG UT WOS:000280364800027 PM 20518569 ER PT J AU Taylor, AJ Fiorilli, PN Wu, HY Bauer, K Bindeman, J Byrd, C Feuerstein, IM O'Malley, PG AF Taylor, Allen J. Fiorilli, Paul N. Wu, Hongyan Bauer, Kelly Bindeman, Jody Byrd, Carole Feuerstein, Irwin M. O'Malley, Patrick G. TI Relation Between the Framingham Risk Score, Coronary Calcium, and Incident Coronary Heart Disease Among Low-Risk Men SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID CARDIAC COMPUTED-TOMOGRAPHY; ARTERY-DISEASE; CHEST-PAIN; INTERVENTION; CARDIOLOGY; RADIOLOGY; COMMITTEE; PACC AB The Prospective Army Coronary Calcium Project is evaluating the predictive value of coronary artery calcium (CAC) in unselected, healthy, lower-risk, 40- to 50-year-old men. Although this study has found that coronary calcium is predictive of future coronary heart disease (CHD), criteria are needed to narrow the screening population to those in whom CAC measurement is most efficient (vs unselected screening of low-risk men). In 1,634 unselected volunteer men (mean age 42 years, mean 10-year CHD Framingham risk score [FRS] 4.6%, CAC prevalence 22.4%), we evaluated the independent relation between CAC and incident CHD over 5.6 years including hard events (hospitalized unstable angina, myocardial infarction, and CHD death) and coronary revascularization. The cohort was analyzed in tertiles of FRS for the relation between CAC and CHD outcomes. FRS tertile cutpoints were 0% to 3% (n = 547), >3% to 5% (n = 547), and >5% (n = 540) 10-year CHD risk. Over a mean follow-up of 5.6 +/- 1.5 years (range 1.0 to 8.3), there were 22 total CHD events, including 14 hard events and 8 revascularizations. Most events occurred in the highest FRS tertile (n = 14) versus the middle (n = 6) and lowest (n = 2) risk tertiles (p = 0.005). CAC and CHD events increased across FRS tertiles. Only in the highest FRS tertile was there a significant relation between CAC and CHD outcomes (hazard ratio 9.3). In conclusion, CAC screening could be of benefit in refining risk assessment of low-risk men, but only when the FRS exceeds approximately 5%. Published by Elsevier Inc. (Am J Cardiol 2010;106:47-50) C1 [Taylor, Allen J.; Fiorilli, Paul N.; Wu, Hongyan; Bauer, Kelly; Bindeman, Jody; Byrd, Carole; O'Malley, Patrick G.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Feuerstein, Irwin M.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Taylor, Allen J.; O'Malley, Patrick G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. EM allen.taylor@medstar.net FU Congressionally Directed, peer-reviewed Medical Research Program, (Fort Detrick, Maryland) [ERMS 00239017-00216] FX This work was supported by the Congressionally Directed, peer-reviewed Medical Research Program (Grant ERMS 00239017-00216) (Fort Detrick, Maryland). NR 10 TC 17 Z9 18 U1 0 U2 2 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD JUL 1 PY 2010 VL 106 IS 1 BP 47 EP 50 DI 10.1016/j.amjcard.2010.02.009 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 622JX UT WOS:000279659700009 PM 20609646 ER PT J AU Karl, JP Lieberman, HR Cable, SJ Williams, KW Young, AJ McClung, JP AF Karl, J. Philip Lieberman, Harris R. Cable, Sonya J. Williams, Kelly W. Young, Andrew J. McClung, James P. TI Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID UNITED-STATES; DIETARY IRON; US-ARMY; DEFICIENCY; WOMEN; BIOAVAILABILITY; ABSORPTION; ANEMIA; FORTIFICATION; PREVALENCE AB Background: Iron status degrades in female soldiers during military training. Inflammation-mediated up-regulation of hepcidin, a key mediator of iron homeostasis, may be a contributing factor. Objective: We measured the efficacy of an iron-fortified food product for maintaining iron status in female soldiers during basic combat training (BCT) and examined relations between iron status, serum hepcidin concentrations, and inflammation. Design: A randomized, double-blind, placebo-controlled trial was conducted. Volunteers received an iron-fortified food product (total dose = 56 mg Fe/d) or a placebo twice daily during the 9-wk BCT course. Iron-status indicators, serum hepcidin concentrations, and markers of inflammation were measured pre- and post-BCT. Results: BCT affected iron status; serum ferritin concentrations decreased (P <= 0.05), and concentrations of soluble transferrin receptor (sTfR) and hemoglobin and the red cell distribution width increased (P <= 0.05). Consumption of the iron-fortified food product attenuated declines in iron status in iron-deficient anemic soldiers; a group-by-time interaction was observed for hemoglobin and sTfR concentrations (P <= 0.05). Serum hepcidin concentrations were not affected by BCT; however, hepcidin concentrations were lower in iron-deficient anemic soldiers than in those with normal iron status (P <= 0.05) and were positively associated with serum ferritin (P <= 0.05) and C-reactive protein (P <= 0.05) concentrations pre- and post-BCT. Conclusions: Twice-daily consumption of an iron-fortified food product improved iron status in iron-deficient anemic soldiers but not in iron-normal or iron-deficient nonanemic soldiers. Serum hepcidin concentrations were not affected by training but were associated with iron status and inflammation pre- and post-BCT. This trial was registered at clinicaltrials.gov as NCT01100905. Am J Clin Nutr 2010; 92: 93-100. C1 [Karl, J. Philip; Lieberman, Harris R.; Young, Andrew J.; McClung, James P.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. RP McClung, JP (reprint author), USA, Mil Nutr Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA USA. EM james.mcclung@amedd.army.mil RI McClung, James/A-1989-2009; OI Karl, J. Philip/0000-0002-5871-2241 FU US Army Medical Research; Materiel Command FX Supported by the US Army Medical Research and Materiel Command. NR 42 TC 24 Z9 24 U1 0 U2 5 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD JUL 1 PY 2010 VL 92 IS 1 BP 93 EP 100 DI 10.3945/ajcn.2010.29185 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 612YX UT WOS:000278943100014 PM 20444958 ER PT J AU Brown, G Shapeero, LG Weiss, BM Roschewski, M AF Brown, Gregory Shapeero, Lorraine G. Weiss, Brendan M. Roschewski, Mark TI Multiple myeloma with lacrimal gland amyloidosis and sarcoidosis SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Editorial Material ID ORBITAL AMYLOIDOSIS; ASSOCIATION; MALIGNANCY AB Our patient, a 46-year-old black woman, diagnosed with pulmonary sarcoidosis at bronchoscopy but without significant symptomatology for 14 years presented to her primary physician with marked bilateral upper eyelid swelling, conjunctival erythema, and dry eyes. Initial laboratory studies including chemistries, urinalysis, and complete blood count were normal. She was treated with topical ophthalmic steroids, because her symptoms and physical findings were thought to be extrapulmonary manifestations of sarcoidosis. Despite several weeks of treatment, her symptoms and physical findings persisted, and she was referred to an ophthalmologist. A computed tomography (CT) scan of the orbits was obtained and confirmed extensive bilateral enlargement of the lacrimal glands. The ophthalmologist concurred with the presumptive diagnosis of orbital sarcoidosis and continued topical treatment. Because of the patient's history of sarcoidosis, although she stated that she had no pulmonary symptoms, she was referred to pulmonary medicine for further clinical evaluation. She underwent radiography and high-resolution chest CT that showed patchy areas of central and peripheral honeycombing fibrosis in the upper lobes of both lungs without hilar adenopathy. These findings were consistent with radiographic Stage IV pulmonary sarcoidosis with multifocal fibrotic changes. Spirometry was normal without restrictive or obstructive abnormalities. Serum nuclear antibodies for Wegener granulomatosis were also negative. C1 [Brown, Gregory] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Shapeero, Lorraine G.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Shapeero, Lorraine G.] Uniformed Serv Univ Hlth Sci, Bone & Soft Tissue Program, US Mil Canc Inst, Dept Radiol, Bethesda, MD 20814 USA. [Shapeero, Lorraine G.] US Mil Canc Inst, Bone & Soft Tissue Sarcoma Program, Washington, DC 20307 USA. [Weiss, Brendan M.; Roschewski, Mark] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. RP Shapeero, LG (reprint author), Uniformed Serv Univ Hlth Sci, Bone & Soft Tissue Program, US Mil Canc Inst, Dept Radiol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. OI Roschewski, Mark/0000-0003-0278-2635 NR 25 TC 3 Z9 3 U1 1 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD JUL PY 2010 VL 85 IS 7 BP 506 EP 509 DI 10.1002/ajh.21695 PG 4 WC Hematology SC Hematology GA 620NI UT WOS:000279506200011 PM 20575017 ER PT J AU Leon, LR Gordon, CJ Helwig, BG Rufolo, DM Blaha, MD AF Leon, Lisa R. Gordon, Christopher J. Helwig, Bryan G. Rufolo, Dennis M. Blaha, Michael D. TI Thermoregulatory, behavioral, and metabolic responses to heatstroke in a conscious mouse model SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE heat stress; fever; hypothermia; poikilothermia; metabolism ID HEAT-STROKE; OLD RATS; MICE; TEMPERATURE; FEVER; POIKILOTHERMIA; MECHANISMS; RECOVERY; YOUNG; TIME AB Leon LR, Gordon CJ, Helwig BG, Rufolo DM, Blaha MD. Thermoregulatory, behavioral, and metabolic responses to heatstroke in a conscious mouse model. Am J Physiol Regul Integr Comp Physiol 299: R241-R248, 2010. First published April 28, 2010; doi:10.1152/ajpregu.00309.2009.-The typical core temperature (T(c)) profile displayed during heatstroke (HS) recovery consists of initial hypothermia followed by delayed hyperthermia. Anecdotal observations led to the conclusion that these Tc responses represent thermoregulatory dysfunction as a result of brain damage. We hypothesized that these Tc responses are mediated by a change in the temperature setpoint. T(c) (+/- 0.1 degrees C; radiotelemetry) of male C57BL/6J mice was monitored while they were housed in a temperature gradient with ambient temperature (T(a)) range of 20-39 degrees C to monitor behaviorally selected T(a) (T(s)) or an indirect calorimeter (T(a) = 25 degrees C) to monitor metabolism ((V) over dotO(2)) and calculate respiratory exchange ratio (RER). Responses to mild and severe HS (thermal area 249.6 +/- 18.9 vs. 299.4 +/- 19.3 degrees C.min, respectively) were examined through 48 h of recovery. An initial hypothermia following mild HS was associated with warm T(s) (similar to 32 degrees C), similar to 35% (V) over dotO(2) decrease, and RER similar to 0.71 that indicated reliance on fatty acid oxidation. After 24 h, mild HS mice developed hyperthermia associated with warm T(s) (similar to 32 degrees C), similar to 20% (V) over dotO(2) increase, and RER similar to 0.85. Severe HS mice appeared poikilothermic-like in the temperature gradient with T(c) similar to T(s) (similar to 20 degrees C), and these mice failed to recover from hypothermia and develop delayed hyperthermia. Cellular damage (hematoxylin and eosin staining) was undetectable in the hypothalamus or other brain regions in severe HS mice. Overall, decreases and increases in T(c) were associated with behavioral and autonomic thermoeffectors that suggest HS elicits anapyrexia and fever, respectively. Taken together, T(c) responses of mild and severe HS mice suggest a need for reinterpretation of the mechanisms of thermoregulatory control during recovery. C1 [Leon, Lisa R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Gordon, Christopher J.] US EPA, Res Triangle Pk, NC 27711 USA. RP Leon, LR (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM lisa.r.leon@us.army.mil FU U.S. Army Medical Research and Materiel Command FX Research was funded by U.S. Army Medical Research and Materiel Command. This article has been approved for public release: distribution is unlimited. NR 28 TC 20 Z9 21 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD JUL PY 2010 VL 299 IS 1 BP R241 EP R248 DI 10.1152/ajpregu.00309.2009 PG 8 WC Physiology SC Physiology GA 616FR UT WOS:000279194900025 PM 20427722 ER PT J AU Wang, RB Urso, ML Zambraski, EJ Rader, EP Campbell, KP Liang, BT AF Wang, Ruibo Urso, Maria L. Zambraski, Edward J. Rader, Erik P. Campbell, Kevin P. Liang, Bruce T. TI Adenosine A(3) receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE beta-sarcoglycan; muscle force; creatine kinase; inflammation ID GIRDLE MUSCULAR-DYSTROPHY; VITAMIN-C SUPPLEMENTATION; REPERFUSION SYNDROME; MAST-CELLS; DAMAGE; SORENESS; MOUSE; ISCHEMIA; MICE; PERFORMANCE AB Wang R, Urso ML, Zambraski EJ, Rader EP, Campbell KP, Liang BT. Adenosine A(3) receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury. Am J Physiol Regul Integr Comp Physiol 299: R259-R267, 2010. First published April 28, 2010; doi: 10.1152/ajpregu.00060.2010.-Effective therapy to reduce skeletal muscle injury associated with severe or eccentric exercise is needed. The purpose of this study was to determine whether adenosine receptor stimulation can mediate protection from eccentric exercise-induced muscle injury. Downhill treadmill exercise (-15 degrees) was used to induce eccentric exercise-mediated skeletal muscle injury. Experiments were conducted in both normal wild-type (WT) mice and also in beta-sarcoglycan knockout dystrophic mice, animals that show an exaggerated muscle damage with the stress of exercise. In the vehicle-treated WT animals, eccentric exercise increased serum creatine kinase (CK) greater than 3-fold to 358.9 +/- 62.7 U/l (SE). This increase was totally abolished by stimulation of the A(3) receptor. In the dystrophic beta-sarcoglycan-null mice, eccentric exercise caused CK levels to reach 55,124 +/- 5,558 U/l. A3 receptor stimulation in these animals reduced the CK response by nearly 50%. In the dystrophic mice at rest, 10% of the fibers were found to be damaged, as indicated by Evans blue dye staining. While this percentage was doubled after exercise, A(3) receptor stimulation eliminated this increase. Neither the A(1) receptor agonist 2-chloro-N-6-cyclo-pentyladenosine (0.05 mg/kg) nor the A(2A) receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (0.07 mg/kg) protected skeletal muscle from eccentric exercise injury in WT or dystrophic mice. The protective effect of adenosine A(3) receptor stimulation was absent in mice, in which genes for phospholipase C beta 2/beta 3 (PLC beta 2/beta 3) and beta-sarcoglycan were deleted. The present study elucidates a new protective role of the A(3) receptor and PLC beta 2/beta 3 and points to a potentially effective therapeutic strategy for eccentric exercise-induced skeletal muscle injury. C1 [Wang, Ruibo; Liang, Bruce T.] Univ Connecticut, Ctr Hlth, Pat & Jim Calhoun Cardiol Ctr, Farmington, CT 06030 USA. [Urso, Maria L.; Zambraski, Edward J.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Rader, Erik P.; Campbell, Kevin P.] Univ Iowa, Howard Hughes Med Inst, Dept Mol Physiol & Biophys, Iowa City, IA 52242 USA. [Rader, Erik P.; Campbell, Kevin P.] Univ Iowa, Howard Hughes Med Inst, Dept Neurol, Iowa City, IA 52242 USA. [Rader, Erik P.; Campbell, Kevin P.] Univ Iowa, Howard Hughes Med Inst, Dept Internal Med, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA. RP Liang, BT (reprint author), Univ Connecticut, Ctr Hlth, Pat & Jim Calhoun Cardiol Ctr, MC 3946,263 Farmington Ave, Farmington, CT 06030 USA. EM bliang@uchc.edu OI Urso, Maria/0000-0001-8906-4673 FU Department of Defense [W81XWH-05-1-0060]; Paul D. Wellstone Muscular Dystrophy Cooperative Research Center [1U54NS053672]; Muscular Dystrophy Association FX This work was supported by a grant from the Department of Defense (W81XWH-05-1-0060 to B. T. Liang). This work was also supported in part by the Paul D. Wellstone Muscular Dystrophy Cooperative Research Center Grant (1U54NS053672 to K. P. Campbell). K. P. Campbell is an Investigator of the Howard Hughes Medical Institute. E. P. Rader was supported by a Muscular Dystrophy Association Development Grant. NR 61 TC 8 Z9 8 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD JUL PY 2010 VL 299 IS 1 BP R259 EP R267 DI 10.1152/ajpregu.00060.2010 PG 9 WC Physiology SC Physiology GA 616FR UT WOS:000279194900027 PM 20427727 ER PT J AU Forman, HP Javitt, MC Monsees, B Larson, DB Norbash, A Kaye, A Beauchamp, NJ Messinger, N AF Forman, Howard P. Javitt, Marcia C. Monsees, Barbara Larson, David B. Norbash, Alexander Kaye, Alan Beauchamp, Norman J., Jr. Messinger, Neil TI Masters of Radiology Panel Discussion: Radiology Extenders-Challenges and Opportunities to Balance the Demands of Our Changing Work Environment SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material DE efficiency; radiology extenders; workflow C1 [Forman, Howard P.] Yale Univ, Dept Diagnost Radiol, New Haven, CT 06510 USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Monsees, Barbara] Washington Univ, Med Ctr, Mallinckrodt Inst Radiol, Breast Imaging Sect, St Louis, MO 63110 USA. [Larson, David B.] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH USA. [Norbash, Alexander] Boston Univ, Med Ctr, Dept Radiol, Boston, MA 02118 USA. [Kaye, Alan] Adv Radiol Consultants, Westport, CT USA. [Kaye, Alan] Bridgeport Hosp, Dept Radiol, Westport, CT USA. [Beauchamp, Norman J., Jr.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA. [Messinger, Neil] Baptist Hlth Syst, Dept Radiol, Miami, FL USA. RP Forman, HP (reprint author), Yale Univ, Dept Diagnost Radiol, New Haven, CT 06510 USA. EM howard.forman@yale.edu OI Norbash, Alexander/0000-0003-2986-2563 NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUL PY 2010 VL 195 IS 1 BP 170 EP 175 DI 10.2214/AJR.10.4619 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 613RQ UT WOS:000278998200023 PM 20566812 ER PT J AU Zapor, MJ Barber, M Summers, A Miller, GH Feeney, LA Eberly, LE Wortmann, G AF Zapor, Michael J. Barber, Melissa Summers, Amy Miller, George H. Feeney, Lee Ann Eberly, Lynn E. Wortmann, Glenn TI In Vitro Activity of the Aminoglycoside Antibiotic Arbekacin against Acinetobacter baumannii-calcoaceticus Isolated from War-Wounded Patients at Walter Reed Army Medical Center SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PSEUDOMONAS-AERUGINOSA; RESISTANCE AB We determined the in vitro MIC of arbekacin against 200 Acinetobacter isolates recovered from wounded soldiers. The median MIC was 2 mu g/ml (range, 0.5 to >64 mu g/ml). A total of 97.5% of the isolates had arbekacin MICs of <8 mu g/ml and 86.5% had MICs of <= 4 mu g/ml. There was no association between the arbekacin MIC and susceptibility to 16 other antibiotics or the specimen source (P = 0.7239). Synergy testing suggested an enhanced effect of arbekacin-carbapenem combinations. C1 [Zapor, Michael J.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Barber, Melissa] Infect Dis Clin Res Program, Washington, DC USA. [Miller, George H.; Feeney, Lee Ann] Achaogen Inc, San Francisco, CA USA. [Eberly, Lynn E.] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA. RP Zapor, MJ (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM michael.zapor@us.army.mil OI Eberly, Lynn/0000-0003-4763-330X NR 20 TC 12 Z9 12 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 2010 VL 54 IS 7 BP 3015 EP 3017 DI 10.1128/AAC.01173-09 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 611TF UT WOS:000278845100036 PM 20404121 ER PT J AU Edmonds, J Clark, P Williams, L Lindquist, HDA Martinez, K Gardner, W Shadomy, S Hornsby-Myers, J AF Edmonds, Jason Clark, Paul Williams, Leslie Lindquist, H. D. Alan Martinez, Kenneth Gardner, Warren Shadomy, Sean Hornsby-Myers, Jennifer TI Multigeneration Cross Contamination of Mail with Bacillus Species Spores by Tumbling SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID INHALATIONAL ANTHRAX OUTBREAK; UNITED-STATES; NONPOROUS SURFACES; BIOTERRORISM; AEROSOLIZATION; WASHINGTON; INFECTION; RECOVERY; WORKERS; RISK AB In 2001, envelopes loaded with Bacillus anthracis spores were mailed to Senators Daschle and Leahy as well as to the New York Post and NBC News buildings. Additional letters may have been mailed to other news agencies because there was confirmed anthrax infection of employees at these locations. These events heightened the awareness of the lack of understanding of the mechanism(s) by which objects contaminated with a biological agent might spread disease. This understanding is crucial for the estimation of the potential for exposure to ensure the appropriate response in the event of future attacks. In this study, equipment to simulate interactions between envelopes and procedures to analyze the spread of spores from a "payload" envelope (i.e., loaded internally with a powdered spore preparation) onto neighboring envelopes were developed. Another process to determine whether an aerosol could be generated by opening contaminated envelopes was developed. Subsequent generations of contaminated envelopes originating from a single payload envelope showed a consistent two-log decrease in the number of spores transferred from one generation to the next. Opening a tertiary contaminated envelope resulted in an aerosol containing 103 B. anthracis spores. We developed a procedure for sampling contaminated letters by a nondestructive method aimed at providing information useful for consequence management while preserving the integrity of objects contaminated during the incident and preserving evidence for law enforcement agencies. C1 [Edmonds, Jason; Clark, Paul; Williams, Leslie; Gardner, Warren] USA, Edgewood Chem Biol Ctr, US Dept Def, Aberdeen Proving Ground, MD 21010 USA. [Lindquist, H. D. Alan] US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, Cincinnati, OH 45268 USA. [Martinez, Kenneth; Hornsby-Myers, Jennifer] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Shadomy, Sean] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30329 USA. RP Edmonds, J (reprint author), USA, Edgewood Chem Biol Ctr, US Dept Def, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM jason.edmonds1@us.army.mil FU Centers for Disease Control and Prevention [07FED703911 (07-18)]; Department of Defense; Edgewood Chemical Biological Center; Department of Health and Human Services; National Institutes for Occupational Safety and Health; Department of Justice; Federal Bureau of Investigation; U.S. Environmental Protection Agency through its Office of Research and Development FX We acknowledge the contribution of Jerry Bottiger of the Aerosol Sciences team at the Edgewood Chemical Biological Center for constructing the mail tumbler. We thank Patricia Collett and Julia Collins at the Edgewood Chemical Biological Center for their technical contributions. Technical guidance and consultation were obtained from a scientific steering committee composed of federal partners, including the CDC, the EPA, the Department of Defense, and the FBI. Specifically, we thank Nicholas Pacquette. Finally, we thank Leslie Custer and Justin Ritmiller of Booz Allen Hamilton for graphic support. Funding (partial) for this project was provided by the Centers for Disease Control and Prevention through Interagency Agreement 07FED703911 (07-18).; The Department of Defense, Edgewood Chemical Biological Center, Department of Health and Human Services, Centers for Disease Control and Prevention, National Institutes for Occupational Safety and Health, Department of Justice, and Federal Bureau of Investigation, as well as the U.S. Environmental Protection Agency through its Office of Research and Development, partially funded and collaborated in the research described here. The manuscript has been subject to Agency review but does not necessarily reflect the views of the Agency. No official endorsement should be inferred. Mention or use of trade names does not constitute endorsement of recommendation for use. NR 29 TC 2 Z9 2 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JUL PY 2010 VL 76 IS 14 BP 4797 EP 4804 DI 10.1128/AEM.02978-09 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 621UX UT WOS:000279611500026 PM 20511424 ER PT J AU Boettcher, EJ Krapels, K Driggers, R Garcia, J Schuetz, C Samluk, J Stein, L Kiser, W Visnansky, A Grata, J Wikner, D Harris, R AF Boettcher, Evelyn J. Krapels, Keith Driggers, Ron Garcia, Jose Schuetz, Christopher Samluk, Jesse Stein, Lee Kiser, William Visnansky, Andrew Grata, Jeremy Wikner, David Harris, Russ TI Modeling passive millimeter wave imaging sensor performance for discriminating small watercraft SO APPLIED OPTICS LA English DT Article AB Passive millimeter wave (pmmW) imagers are quickly becoming practical sensor candidates for military and nonmilitary tasks. Our focus was to adapt the Night Vision [U. S. Army Research Development and Engineering Command, Communications and Electronics Research Development and Engineering Center, Night Vision and Electronics Sensors Directorate (NVESD)] passive thermal infrared imager performance models and apply them to pmmW imaging systems for prediction of field performance for the task of small watercraft and boat identification. The Night Vision Lab's infrared sensor model has been evolving since the 1950s, with the most current model being NVThermIP [Night Vision Thermal and Image Processing (NVThermIP) Model Users Manual, Rev. 9 (U. S. Army RDECON, CERDEC, NVESD, 2006)]. It has wide recognition as an engineering tool for sensor evaluation. This effort included collecting pmmW signatures for a representative set of targets, conducting an observer perception experiment, and deriving the task difficulty criteria that can be used in NVThermIP for identification of boats. The task difficulty criteria are used by designers and managers to create systems capable of meeting specific performance criteria in the field. (C) 2010 Optical Society of America C1 [Boettcher, Evelyn J.] DCS Corp, Alexandria, VA 22310 USA. [Krapels, Keith; Driggers, Ron; Garcia, Jose] ONR NRL Sci & Technol Reserves, Washington, DC 20036 USA. [Schuetz, Christopher; Samluk, Jesse; Stein, Lee] Univ Delaware, Newark, DE 19716 USA. [Kiser, William; Visnansky, Andrew; Grata, Jeremy] Penn State Univ, Ctr Electroopt, Freeport, PA 16229 USA. [Wikner, David; Harris, Russ] USA, Res Lab, Adelphi, MD 20783 USA. RP Boettcher, EJ (reprint author), DCS Corp, 6909 Metro Pk Dr,Suite 500, Alexandria, VA 22310 USA. EM evelyn.boettcher@gmail.com FU United States Navy, Office of Naval Research (ONR) FX This work was funded by the United States Navy, Office of Naval Research (ONR). NR 16 TC 9 Z9 9 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 1 PY 2010 VL 49 IS 19 BP E58 EP E66 DI 10.1364/AO.49.000E58 PG 9 WC Optics SC Optics GA 619BO UT WOS:000279403400009 PM 20648122 ER PT J AU Cull, CF Wikner, DA Mait, JN Mattheiss, M Brady, DJ AF Cull, Christy Fernandez Wikner, David A. Mait, Joseph N. Mattheiss, Michael Brady, David J. TI Millimeter-wave compressive holography SO APPLIED OPTICS LA English DT Article ID DIFFRACTION TOMOGRAPHY; RECONSTRUCTION; ALGORITHMS AB We describe an active millimeter-wave holographic imaging system that uses compressive measurements for three-dimensional (3D) tomographic object estimation. Our system records a two-dimensional (2D) digitized Gabor hologram by translating a single pixel incoherent receiver. Two approaches for compressive measurement are undertaken: nonlinear inversion of a 2D Gabor hologram for 3D object estimation and nonlinear inversion of a randomly subsampled Gabor hologram for 3D object estimation. The object estimation algorithm minimizes a convex quadratic problem using total variation (TV) regularization for 3D object estimation. We compare object reconstructions using linear backpropagation and TV minimization, and we present simulated and experimental reconstructions from both compressive measurement strategies. In contrast with backpropagation, which estimates the 3D electromagnetic field, TV minimization estimates the 3D object that produces the field. Despite undersampling, range resolution is consistent with the extent of the 3D object band volume. (C) 2010 Optical Society of America C1 [Cull, Christy Fernandez; Brady, David J.] Duke Univ, Fitzpatrick Inst Photon, Durham, NC 27708 USA. [Cull, Christy Fernandez; Brady, David J.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. [Wikner, David A.; Mait, Joseph N.] USA, Res Lab, Adelphi, MD 20783 USA. [Mattheiss, Michael] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RP Cull, CF (reprint author), Duke Univ, Fitzpatrick Inst Photon, 129 Hudson Hall, Durham, NC 27708 USA. EM caf11@ee.duke.edu FU National Defense Science and Engineering Graduate Fellowship FX The authors would like to thank Ryoichi Horisaki, a member of the compressive holography team at Duke University, for his valuable suggestions. C. F. Cull acknowledges the support of a National Defense Science and Engineering Graduate Fellowship. NR 31 TC 52 Z9 54 U1 2 U2 27 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 1 PY 2010 VL 49 IS 19 BP E67 EP E82 DI 10.1364/AO.49.000E67 PG 16 WC Optics SC Optics GA 619BO UT WOS:000279403400010 PM 20648123 ER PT J AU Krapels, KA Salmon, NA Wikner, DA Schuetz, CA AF Krapels, Keith A. Salmon, Neil A. Wikner, David A. Schuetz, Christopher A. TI RF Imaging, Architectures, and Applications: introduction to the feature issue SO APPLIED OPTICS LA English DT Editorial Material C1 [Schuetz, Christopher A.] Phase Sensit Innovat Inc, Newark, DE 19711 USA. [Krapels, Keith A.] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Salmon, Neil A.] QinetiQ, Malvern WR14 3PS, Worcs, England. [Wikner, David A.] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Schuetz, CA (reprint author), Phase Sensit Innovat Inc, Newark, DE 19711 USA. EM schuetz@phasesensitiveinc.com NR 0 TC 0 Z9 0 U1 1 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 1 PY 2010 VL 49 IS 19 BP RFI1 EP RFI1 DI 10.1364/AO.49.00RFI1 PG 1 WC Optics SC Optics GA 619BO UT WOS:000279403400001 PM 20648127 ER PT J AU Holthoff, EL Bright, FV AF Holthoff, Ellen L. Bright, Frank V. TI Photophysics Associated with Site Selectively Templated and Tagged Xerogel Sensor Platforms SO APPLIED SPECTROSCOPY LA English DT Article DE Fluorescence; Sensors; Molecular imprinting; Photophysics ID LIFETIME DISTRIBUTIONS; FLUORESCENCE LIFETIME; FLUOROMETRY AB The analytical signal produced from a site selectively templated and tagged xerogel (SSTTX) based sensor is more completely elucidated. In an SSTTX, target analyte (TA) binding sites are created within a xerogel and a fluorescent reporter molecule (e.g., nitrobenzo-2-oxa-1,3-diazole, NBD) is covalently and selectively positioned within the template site. TA binding modulates the NBD cybotactic region, yielding a TA concentration-dependent change in the NBD reporter fluorescence. Our results reveal that there are two NBD sub-populations within the SSTTX. One sub-population is associated with misformed template sites that bind TA poorly and the NBD reporter molecules are heavily quenched by an adjacent amine residue that is intentionally positioned within close proximity to the NBD reporter molecule. The second NBD sub-population is associated with a properly formed template site that binds TA; the adjacent amine is still present but it is not as close to the NBD in comparison to the misformed site. When TA is present, the TA-responsive site binds TA, the TA disrupts the adjacent amine NBD interaction (dequenching), and the NBD fluorescence increases. All NBD quenching occurs via photo-induced electron transfer (PET) from the adjacent amines to the excited NBD reporter molecules. As the mole fraction ratio of n-octyltrimethoxysilane (C(8)-TMOS) to tetramethoxysilane (TMOS) within an SSTTX increases, the misformed site mole fraction decreases and the dissociation constant (K(d)) for TA binding to the TA-responsive site decreases by 13-fold. C1 [Bright, Frank V.] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA. [Holthoff, Ellen L.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. RP Bright, FV (reprint author), SUNY Buffalo, Dept Chem, Nat Sci Complex, Buffalo, NY 14260 USA. EM chefvb@buffalo.edu OI Bright, Frank/0000-0002-1500-5969 FU National Science Foundation [CHE-0848171] FX This research is based in part upon work supported by the National Science Foundation under Grant Number CHE-0848171. Any opinions, findings. and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. NR 24 TC 3 Z9 3 U1 0 U2 8 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JUL PY 2010 VL 64 IS 7 BP 714 EP 719 PG 6 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 623BY UT WOS:000279713500005 PM 20615283 ER PT J AU Roberson, SD Sausa, RC AF Roberson, Stephen D. Sausa, Rosario C. TI Laser-Based Detection of TNT and RDX Residues in Real Time Under Ambient Conditions SO APPLIED SPECTROSCOPY LA English DT Article DE Laser photofragmentation; Resonance-enhanced ionization; REMPI; Energetic materials; Explosives detection ID FRAGMENT DETECTION SPECTROSCOPY; EXCITED ELECTRONIC STATES; PHOTODISSOCIATION DYNAMICS; REMOTE DETECTION; UNIQUE SCHEME; EXPLOSIVES; PHOTOFRAGMENTATION; FEMTOSECOND; PHASE; IDENTIFICATION AB We detect thin films of 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-hexanitro-1,3,5-triazine (RDX) by one- and two-laser photofragmentation-fragment detection spectroscopy in real time at ambient temperature and pressure. In the one-laser technique, a laser tuned to 226 nm excites the energetic material and both generates the characteristic NO photofragments and facilitates their detection by resonance-enhanced multi-photon ionization (REMPI) using their A-X (0,0) transitions near 226 nm. In contrast, in the two-laser technique, a 454 nm laser generates the analyte molecule in the gas phase by matrix-assisted desorption, and a second laser tuned to 226 nm both photofragments it and ionizes the resulting NO. We report the effects of laser energy, analyte concentration, and matrix concentration on the ion signal and determine the rotational temperatures of the NO photofragments from Boltzmann, rotational distribution analysis of the REMPI spectra. We achieve limits of detection (S/N = 3) of hundreds of ng/cm(2) for both techniques under ambient conditions with a positive signal identification as low as 70 pg using a single 226 nm laser pulse of similar to 50 mu J. C1 [Roberson, Stephen D.; Sausa, Rosario C.] USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Sausa, RC (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM sausa@arl.army.mil FU National Research Council FX We thank Dr. Rose Pesce-Rodriguez for providing us with the TNT and RDX samples and Dr. Michael Grams for his invaluable assistance. Also, we thank Mr. Matthew Bratcher and Ms. Kristin Denault for the use of their profilometer and Mr. Donovan Harris for the use of his imaging microscope. Support from the National Research Council Postdoctoral Research Associateship Program is greatly appreciated. NR 25 TC 5 Z9 5 U1 2 U2 12 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JUL PY 2010 VL 64 IS 7 BP 760 EP 766 PG 7 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 623BY UT WOS:000279713500011 PM 20615289 ER PT J AU Khan, JR Lear, WE Sherif, SA Howell, EB Crittenden, JF Meitner, PL AF Khan, J. R. Lear, W. E. Sherif, S. A. Howell, E. B. Crittenden, J. F. Meitner, P. L. TI A novel pressurized CHP system with water extraction and refrigeration SO APPLIED THERMAL ENGINEERING LA English DT Article DE Semi-closed gas turbine; Combined cycles; Water extraction; Absorption refrigeration ID CYCLE AB A novel Cooling, Heat, and Power (CHP) system has been proposed that features a semi-closed Brayton cycle with pressurized recuperation, integrated with a Vapor Absorption Refrigeration System (VARS). The semi-closed Brayton cycle is called the High Pressure Regenerative Turbine Engine (HPRTE). The VARS interacts with the HPRTE power cycle through heat exchange in the generator and the evaporator. Waste heat from the recirculated combustion gas of the HPRTE is used to power the absorption refrigeration unit, which cools the high-pressure compressor inlet of the HPRTE to below ambient conditions and also produces excess refrigeration in an amount which depends on ambient conditions. Water produced as a product of combustion is intentionally condensed in the evaporator of the VARS, which is designed to provide sufficient cooling for the inlet air to the high-pressure compressor, water extraction, and for an external cooling load. The computer model of the combined HPRTE/VARS cycle predicts that with steam blade cooling and a medium-sized engine, the cycle will have a thermal efficiency of 49% for a turbine inlet temperature of 1400 degrees C. This thermal efficiency is in addition to the large external cooling load generated in the combined cycle which is 13% of the net work output. In addition it also produces up to 1.4 kg of water for each kg of fuel consumed, depending upon the fuel type. When the combined HPRTE/VARS cycle is optimized for maximum thermal efficiency, the optimum occurs for a broad range of operating conditions. Details of the multivariate optimization procedure and results are presented in the paper. Previous studies have demonstrated the following attributes of the combined HPRTE/VARS cycle: attaining high part power efficiency in a compact package, threefold specific power increase over the state of the art, reduced IR signatures due to lower exhaust temperature, significant reduction of exhaust particulates and smoke, constant high-pressure compressor inlet temperature and order-of-magnitude reductions in emissions such as NO(x), CO and unburned hydrocarbons. The integrated nature of this system allows overall reduction in size and weight of approximately 50% relative to conventional equipment. The combination of positive attributes makes the HPRTE combined cycle engine attractive for future mobile power applications in terms of performance as well as life cycle cost. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Khan, J. R.; Lear, W. E.; Sherif, S. A.; Howell, E. B.; Crittenden, J. F.] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. [Meitner, P. L.] USA, Res Lab, Vehicle Technol Directorate, Cleveland, OH 44135 USA. RP Sherif, SA (reprint author), Univ Florida, Dept Mech & Aerosp Engn, POB 116300, Gainesville, FL 32611 USA. EM sasherif@ufl.edu FU US Army [W911QX-05-C-0007]; University of Florida by Triad Research Corporation, Inc., Gainesville, Florida; US/Egypt Science and Technology Joint Board; Department of Mechanical and Aerospace Engineering at the University of Florida FX This paper is based on research supported by the US Army under contract number W911QX-05-C-0007. The project was subcontracted to University of Florida by Triad Research Corporation, Inc., Gainesville, Florida. Partial support from the US/Egypt Science and Technology Joint Board as well as the Department of Mechanical and Aerospace Engineering at the University of Florida is also gratefully acknowledged. NR 30 TC 2 Z9 2 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-4311 J9 APPL THERM ENG JI Appl. Therm. Eng. PD JUL PY 2010 VL 30 IS 10 BP 1081 EP 1090 DI 10.1016/j.applthermaleng.2009.11.010 PG 10 WC Thermodynamics; Energy & Fuels; Engineering, Mechanical; Mechanics SC Thermodynamics; Energy & Fuels; Engineering; Mechanics GA 598RT UT WOS:000277856600001 ER PT J AU Sneshkoff, NT Freeman, JH Liming, BJ AF Sneshkoff, Nikolaus T. Freeman, Judy H. Liming, Bryan J. TI Pathology Quiz Case 2 Merkel cell carcinoma (MCC) of the left auricle SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material ID HEAD; NECK; EXPERIENCE; THERAPY C1 [Sneshkoff, Nikolaus T.; Freeman, Judy H.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Liming, Bryan J.] Ohio State Univ, Sch Med, Columbus, OH 43210 USA. RP Sneshkoff, NT (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 10 TC 1 Z9 1 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD JUL PY 2010 VL 136 IS 7 BP 745 EP + PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 625WA UT WOS:000279926300021 PM 20644078 ER PT J AU Wenke, JC Warren, GL Rathbone, CR Armstrong, RB AF Wenke, Joseph C. Warren, Gordon L. Rathbone, Christopher R. Armstrong, Robert B. TI Mouse Plantar Flexor Muscle Size and Strength After Inactivity and Training SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE eccentric contraction; microgravity; exercise ID CONTRACTION-INDUCED INJURY; SKELETAL-MUSCLE; HINDLIMB SUSPENSION; SOLEUS MUSCLE; RAT HINDLIMB; SARCOMERE NUMBER; TIME-COURSE; ATROPHY; EXERCISE; HYPOKINESIA AB WENKE JC, WARREN GL, RATHBONE CR, ARMSTRONG RB. Mouse plantar flexor muscle size and strength after inactivity and training. Aviat Space Environ Med 2010; 81:632-8. Introduction: Losses in muscle mass and strength may affect an astronaut's safety; therefore, it is of utmost importance to optimize countermeasures to minimize atrophy and strength loss during space-flight. The main purpose of this study was to determine if high force eccentric or isometric contractions performed by the plantar flexor group during hind limb suspension would preserve muscle mass and strength. Methods: Plantar flexor muscles of mice were trained with either eccentric or isometric contractions every other day during a 10-d hind limb suspension period. Pre- and post-suspension stimulation frequency- and angular velocity-dependent measurements of torque of the plantar flexors, soleus twitch (P(t)) and tetanic (P(o)) force, bodyweight, and muscle wet weight measurements were made. Results: The 19 and 26% losses in gastrocnemius and soleus muscle wet weights, respectively, were not attenuated with eccentric or isometric contractions. Neither eccentric nor isometric contractions attenuated the soleus muscle's 30% isometric force loss after hind limb suspension. Despite losses in muscle mass, there was no decrease in the force produced by the plantar flexor muscle group after hind limb suspension. Discussion: Hind limb suspension decreased both gastrocnemius and soleus mass, and in vitro soleus force production. However, in vivo force production of the plantar flexor muscle group did not decrease, which may be explained by a shift in the isometric torque: ankle angle relationship. The use of eccentric or isometric contractions as a countermeasure to offset muscle mass and strength requires further investigation as neither was capable of maintaining soleus muscle force production, or gastrocnemius and soleus muscle mass during hind limb suspension. C1 [Wenke, Joseph C.; Rathbone, Christopher R.; Armstrong, Robert B.] Texas A&M Univ, Dept Hlth & Kinesiol, Muscle Biol Lab, College Stn, TX USA. [Warren, Gordon L.] Georgia State Univ, Div Phys Therapy, Atlanta, GA 30303 USA. RP Wenke, JC (reprint author), USA, Regenerat Med Task Area, Inst Surg Res, 3400 Rawley E Chambers Ave,Ste B, Ft Sam Houston, TX 78234 USA. EM joseph.wenke@us.army.mil RI Warren, Gordon/A-9794-2008 OI Warren, Gordon/0000-0002-7073-8524 NR 27 TC 1 Z9 1 U1 0 U2 11 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 2010 VL 81 IS 7 BP 632 EP 638 DI 10.3357/ASEM.2707.2010 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 616CZ UT WOS:000279187200002 PM 20597241 ER PT J AU Temme, LA Still, DL Acromite, MT AF Temme, Leonard A. Still, David L. Acromite, Michael T. TI Hypoxia and Flight Performance of Military Instructor Pilots in a Flight Simulator SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE hypoxia; flight performance; aviation; simulation; instrument flight; reduced oxygen breathing device; ROBD AB TEMME LA, STILL DL, ACROMITE MT. Hypoxia and flight performance of military instructor pilots in a flight simulator. Aviat Space Environ Med. 2010; 81:7:654-9. Introduction: Military aircrew and other operational personnel frequently perform their duties at altitudes posing a significant hypoxia risk, often with limited access to supplemental oxygen. Despite the significant risk hypoxia poses, there are few studies relating it to primary flight performance, which is the purpose of the present study. Methods: Objective, quantitative measures of aircraft control were collected from 14 experienced, active duty instructor pilot volunteers as they breathed an air/nitrogen mix that provided an oxygen partial pressure equivalent to the atmosphere at 18,000 ft (5486.4 m) above mean sea level. The flight task required holding a constant airspeed, altitude, and heading at an airspeed significantly slower than the aircraft's minimum drag speed. The simulated aircraft's inherent instability at the target speed challenged the pilot to maintain constant control of the aircraft in order to minimize deviations from the assigned flight parameters. Results: Each pilot's flight performance was evaluated by measuring all deviations from assigned target values. Hypoxia degraded the pilot's precision of altitude and airspeed control by 53%, a statistically significant decrease in flight performance. The effect on heading control effects was not statistically significant. There was no evidence of performance differences when breathing room air pre- and post-hypoxia. Discussion: Moderate levels of hypoxia degraded the ability of military instructor pilots to perform a precision slow flight task. This is one of a small number of studies to quantify an effect of hypoxia on primary flight performance. C1 [Temme, Leonard A.; Still, David L.] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. [Acromite, Michael T.] USN, Aerosp Med Inst, Pensacola, FL USA. RP Temme, LA (reprint author), USA, Aeromed Res Lab, POB 620577, Ft Rucker, AL 36362 USA. EM Leonard.temme@us.army.mil FU Naval Aerospace Medical Research Laboratory (NAMRL) [FY02-03] FX The authors are grateful to the Naval Aerospace Medical Research Laboratory (NAMRL) for supporting this research through the Annual Navy Medical In-House Laboratory Independent Research (ILIR) Program (FY02-03) under the project: "Flight Performance With A Human-Centered Computing Cockpit Display System, OZ, Under Hypoxic Conditions." NR 15 TC 8 Z9 11 U1 2 U2 12 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 2010 VL 81 IS 7 BP 654 EP 659 DI 10.3357/ASEM.2690.2010 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 616CZ UT WOS:000279187200005 PM 20597244 ER PT J AU Caridha, D Kathcart, AK Jirage, D Waters, NC AF Caridha, Diana Kathcart, April K. Jirage, Dayadevi Waters, Norman C. TI Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Malaria; Plasmodium; Pfmrk; CDK inhibitor; CDK7; Kinase; Cancer; Cell cycle ID PLASMODIUM-FALCIPARUM; CELL-CYCLE; SELECTIVE INHIBITORS; TUMOR-CELLS; PFMRK; DESIGN; CDK; EXPRESSION; IDENTIFICATION; DISCOVERY AB Cyclin dependent protein kinases (CDKs) are pursued as drug targets for several eukaryotic pathogens. In this study, we identified thiophene and benzene sulfonamides as potent inhibitors of Pfmrk, a Plasmodium falciparum CDK with sequence homology to human CDK7. Several of the compounds demonstrated inhibitor selectivity for CDK7 over CDK1, CDK2, and CDK6. The compounds are moderate antimalarial agents against drug resistant parasites and possess encouraging in vitro therapeutic indices as determined against human cell lines. One particular sub-class of compounds, bromohydrosulfonylacetamides, was specific for Pfmrk with IC(50) values in the sub-micromolar range. These compounds represent the most potent Pfmrk inhibitors reported and provide support for further characterization and derivation as potential antimalarial agents. Published by Elsevier Ltd. C1 [Caridha, Diana; Kathcart, April K.; Jirage, Dayadevi; Waters, Norman C.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Waters, NC (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM norman.waters@us.army.mil NR 33 TC 17 Z9 17 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD JUL 1 PY 2010 VL 20 IS 13 BP 3863 EP 3867 DI 10.1016/j.bmcl.2010.05.039 PG 5 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 609GT UT WOS:000278644700006 PM 20627564 ER PT J AU Pan, IJ Daniels, JL Zhu, KM AF Pan, I-Jen Daniels, Julie L. Zhu, Kangmin TI Poverty and childhood cancer incidence in the United States SO CANCER CAUSES & CONTROL LA English DT Article DE Childhood cancer; Poverty; SEER; Incidence; Epidemiology ID DISPARITIES GEOCODING PROJECT; SOCIOECONOMIC-STATUS; BIRTH-WEIGHT; LEUKEMIA; MORTALITY; METAANALYSIS; CANADA; HEALTH; TUMORS AB This study examined socioeconomic differentials in cancer incidence rates during 2000-2005 among children aged 0-19 in the United States. The data on childhood cancers, which were classified by the International Classification of Childhood Cancer, Third Edition (ICCC-3), were obtained from the Surveillance, Epidemiology, and End Results program. The socioeconomic status of residential area at diagnosis was estimated by county-level poverty rate in Census 2000, i.e., percentage of persons in the county living below the national poverty thresholds. Counties were categorized as low-, medium-, and high-poverty areas when the poverty rates were < 10, 10-19.99, and 20% or higher, respectively. The results showed that medium- and high-poverty counties had lower age-adjusted incidence rates than low-poverty counties for total childhood cancers combined, central nervous system neoplasms (ICCC group III), neuroblastoma (group IV), renal tumors (group VI), and other malignant epithelial neoplasms and malignant melanomas (group XI). When the data were stratified by race, these associations were observed among whites, but not blacks. For leukemia (group I), poor counties had higher incidence rates than affluent counties for whites, but lower rates for blacks. This ecologic study provides perspective on area socioeconomic variations in childhood cancer incidence that warrants further research. C1 [Pan, I-Jen; Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Div Epidemiol & Biostat, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Pan, I-Jen; Zhu, Kangmin] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. [Daniels, Julie L.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA. [Daniels, Julie L.] Univ N Carolina, Dept Maternal & Child Hlth, Chapel Hill, NC 27599 USA. RP Pan, IJ (reprint author), Uniformed Serv Univ Hlth Sci, Div Epidemiol & Biostat, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd,A1039F, Bethesda, MD 20814 USA. EM ijenpan@gmail.com FU United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under Henry M. Jackson Foundation for the Advancement of Military Medicine FX This research was supported by the United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine. The content of this paper represents the authors' personal opinions, which should not be construed as the official views of the Uniformed Services University of the Health Sciences, the Walter Reed Army Medical Center, the US Department of Defense, or the US Government. NR 24 TC 14 Z9 14 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-5243 J9 CANCER CAUSE CONTROL JI Cancer Causes Control PD JUL PY 2010 VL 21 IS 7 BP 1139 EP 1145 DI 10.1007/s10552-010-9528-3 PG 7 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 608WE UT WOS:000278615900016 PM 20198506 ER PT J AU Nauman, EB Armstrong, M Horak, J AF Nauman, E. Bruce Armstrong, Mathew Horak, Jakub TI Static mixers for laminar flow reactors with low aspect ratios SO CHEMICAL ENGINEERING AND PROCESSING LA English DT Article DE Static mixers; Laminar flow; Sterilization; Residence time; First appearance time AB Conventional static mixers typically require high length to diameter ratios to be effective. This paper considers static mixers design to increase first appearance times in short, fat reactors. Three types are considered: conical baffles and annular baffles for tubular reactors and axial baffles for reactors with a rectangular cross-section. Relatively simple designs allow production increases (or reactor volume decreases) on the order of 20-50%. (C) 2009 Published by Elsevier B.V. C1 [Nauman, E. Bruce; Horak, Jakub] Rensselaer Polytech Inst, Troy, NY 12181 USA. [Armstrong, Mathew] US Mil Acad, West Point, NY 10996 USA. RP Nauman, EB (reprint author), Rensselaer Polytech Inst, Troy, NY 12181 USA. EM nauman@rpi.edu NR 3 TC 0 Z9 0 U1 2 U2 6 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0255-2701 J9 CHEM ENG PROCESS JI Chem. Eng. Process. PD JUL PY 2010 VL 49 IS 7 SI SI BP 649 EP 652 DI 10.1016/j.cep.2009.06.005 PG 4 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 653SN UT WOS:000282117100004 ER PT J AU Sanghera, NK Newman, TL AF Sanghera, Navjit K. Newman, Tricia L. TI Cytomegaloviral retinitis from chronic immunosuppression following solid organ transplant surgery SO CLINICAL AND EXPERIMENTAL OPTOMETRY LA English DT Article C1 [Sanghera, Navjit K.; Newman, Tricia L.] Illinois Coll Optometry, Chicago, IL USA. RP Sanghera, NK (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave,Bldg 2,7461, Washington, DC 20307 USA. EM navjit.sanghera@gmail.com NR 10 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0816-4622 J9 CLIN EXP OPTOM JI Clin. Exp. Optom. PD JUL PY 2010 VL 93 IS 4 BP 261 EP 263 DI 10.1111/j.1444-0938.2010.00469.x PG 3 WC Ophthalmology SC Ophthalmology GA 619BF UT WOS:000279401400010 PM 20465550 ER PT J AU Aboud, S Nilsson, C Karlen, K Marovich, M Wahren, B Sandstrom, E Gaines, H Biberfeld, G Godoy-Ramirez, K AF Aboud, Said Nilsson, Charlotta Karlen, Katarina Marovich, Mary Wahren, Britta Sandstrom, Eric Gaines, Hans Biberfeld, Gunnel Godoy-Ramirez, Karina TI Strong HIV-Specific CD4(+) and CD8(+) T-Lymphocyte Proliferative Responses in Healthy Individuals Immunized with an HIV-1 DNA Vaccine and Boosted with Recombinant Modified Vaccinia Virus Ankara Expressing HIV-1 Genes SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID CELL RESPONSES; SUCCINIMIDYL ESTER; FLOW-CYTOMETRY; WHOLE-BLOOD; INFECTION; PRESERVATION; CAPACITY; REGIMEN; VIREMIA; PRIME AB We investigated HIV-1 vaccine-induced lymphoproliferative responses in healthy volunteers immunized intradermally or intramuscularly (with or without adjuvant granulocyte-macrophage colony-stimulating factor [GM-CSF] protein) with DNA expressing HIV-1 gag, env, rev, and rt at months 0, 1, and 3 using a Biojector and boosted at 9 months with modified vaccinia virus Ankara (MVA) expressing heterologous HIV-1 gag, env, and pol (HIV-MVA). Lymphoproliferative responses to aldrithiol-2 (AT-2)-inactivated-HIV-1 antigen were tested by a [H-3] thymidine uptake assay and a flow-cytometric assay of specific cell-mediated immune response in activated whole blood (FASCIA-WB) 2 weeks after the HIV-MVA boost (n = 38). A FASCIA using peripheral blood mononuclear cells (FASCIA-PBMC) was also employed (n = 14). Thirty-five of 38 (92%) vaccinees were reactive by the [H-3] thymidine uptake assay. Thirty-two of 38 (84%) vaccinees were reactive by the CD4(+) T-cell FASCIA-WB, and 7 of 38 (18%) also exhibited CD8(+) T-cell responses. There was strong correlation between the proliferative responses measured by the [H-3] thymidine uptake assay and CD4(+) T-cell FASCIA-WB (r = 0.68; P < 0.01). Fourteen vaccinees were analyzed using all three assays. Ten of 14 (71%) and 11/14 (79%) demonstrated CD4(+) T-cell responses in FASCIA-WB and FASCIA-PBMC, respectively. CD8(+) T-cell reactivity was observed in 3/14 (21%) and 7/14 (50%) using the FASCIA-WB and FASCIA-PBMC, respectively. All 14 were reactive by the [H-3] thymidine uptake assay. The overall HIV-specific T-cell proliferative response in the vaccinees employing any of the assays was 100% (38/38). A standardized FASCIA-PBMC, which allows simultaneous phenotyping, may be an option to the [H-3] thymidine uptake assay for assessment of vaccine-induced T-cell proliferation, especially in isotope-restricted settings. C1 [Nilsson, Charlotta; Karlen, Katarina; Wahren, Britta; Gaines, Hans; Biberfeld, Gunnel; Godoy-Ramirez, Karina] Swedish Inst Infect Dis Control, SE-17182 Solna, Sweden. [Aboud, Said] Muhimbili Univ Hlth & Allied Sci, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania. [Aboud, Said; Nilsson, Charlotta; Wahren, Britta; Gaines, Hans; Biberfeld, Gunnel] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. [Marovich, Mary] Walter Reed Army Inst Res, Dept Retrovirol, Rockville, MD USA. [Sandstrom, Eric] Karolinska Inst, Dept Educ & Clin Res, Stockholm, Sweden. RP Godoy-Ramirez, K (reprint author), Swedish Inst Infect Dis Control, SE-17182 Solna, Sweden. EM karina.godoy@smi.se FU Swedish International Development Cooperation Agency (Sida); Department for Research Cooperation; SAREC [SWE-2004-120, HIV2004-000809, 2004:813]; European Union [INCO-DEV A4 ICFP501A4PR03] FX This work was supported by funding from the Swedish International Development Cooperation Agency (Sida), Department for Research Cooperation, SAREC (SWE-2004-120 to C.N., HIV2004-000809 to G. B., and 2004: 813 to G. B.), and the European Union (INCO-DEV A4 ICFP501A4PR03 to E. S.). NR 26 TC 24 Z9 24 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JUL PY 2010 VL 17 IS 7 BP 1124 EP 1131 DI 10.1128/CVI.00008-10 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 633WE UT WOS:000280536700010 PM 20463104 ER PT J AU Scher, DL Owens, BD Sturdivant, RX Wolf, JM AF Scher, Danielle L. Owens, Brett D. Sturdivant, Rodney X. Wolf, Jennifer Moriatis TI Incidence of Joint Hypermobility Syndrome in a Military Population: Impact of Gender and Race SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID ARTICULAR MOBILITY; LAXITY; OSTEOARTHRITIS; PREVALENCE; BENIGN; DISLOCATION; STUDENTS; FEATURES; CRITERIA; KNEE AB Joint hypermobility syndrome is defined by abnormal laxity in multiple joints in association with symptomatic joint pain. Previous studies in small populations suggest a predominance of female gender and nonwhite race among those diagnosed with hypermobility syndrome. We investigated the epidemiology of joint hypermobility in a large military population, presuming this syndrome would be less prevalent in this specialized population but that demographic analysis would reveal risk factors for this rare condition. We queried the Defense Medical Epidemiology Database by race, gender, military service, and age for the years 1998 to 2007 using the International Classification of Diseases, 9th Revision code 728.5 (hypermobility syndrome). We identified 790 individuals coded for joint hypermobility syndrome among a population at risk of 13,779,234 person-years for a raw incidence rate of 0.06 per 1000 person-years. Females had a higher incidence rate for joint hypermobility syndrome compared with males. Racial stratification showed service members of white race had higher rates of joint hypermobility syndrome compared with service members categorized as black and "other." In a large, established military database it appears joint hypermobility syndrome is a rare condition within the young, active population we studied and female gender is the most important risk factor. Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence. C1 [Scher, Danielle L.; Owens, Brett D.] William Beaumont Army Med Ctr, Dept Surg, Orthopaed Surg Serv, El Paso, TX 79920 USA. [Sturdivant, Rodney X.] US Mil Acad, Dept Math Sci, Ctr Data Anal & Stat, West Point, NY 10996 USA. [Wolf, Jennifer Moriatis] Univ Colorado Denver, Dept Orthopaed Surg, Aurora, CO 80045 USA. RP Wolf, JM (reprint author), Univ Colorado Denver, Dept Orthopaed Surg, 12631 E 17th Ave,Room 4602, Aurora, CO 80045 USA. EM Jennifer.Wolf@ucdenver.edu NR 43 TC 12 Z9 12 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD JUL PY 2010 VL 468 IS 7 BP 1790 EP 1795 DI 10.1007/s11999-009-1182-2 PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 607QM UT WOS:000278521400012 PM 19960283 ER PT J AU Dawood, M Taylor, E Ballew, W Rizkalla, S AF Dawood, M. Taylor, E. Ballew, W. Rizkalla, S. TI Static and fatigue bending behavior of pultruded GFRP sandwich panels with through-thickness fiber insertions SO COMPOSITES PART B-ENGINEERING LA English DT Article DE 3-Dimensional reinforcement; Mechanical properties; Analytical modeling; Mechanical testing ID FOAM; CORE; COMPOSITES; BEAMS; COMPRESSION; DAMAGE AB This paper presents the findings of a research program that was undertaken to evaluate the static and fatigue characteristics of an innovative 3-D glass fiber reinforced polymer (GFRP) sandwich panel proposed for civil infrastructure and transportation applications. The research consists of analytical modeling verified by experimental results. A rational analytical model is presented and used to evaluate the effective elastic modulus, shear modulus and degree of composite interaction of the panels to resist one-way bending. The experimental program was conducted in two phases to study the static and fatigue behavior of the panels. In the first phase a total of 730 sandwich beams were tested to evaluate the effect of different parameters on the fundamental behavior of the panel. The parameters considered include the pattern and density of through-thickness fiber insertions, the overall thickness of the panels, and the number of FRP plies in the face skins. The study indicates that the shear behavior and degree of composite interaction of the panels is sensitive to the configuration of the panel core. The second phase of the experimental program included testing of 24 additional sandwich panels to evaluate the fatigue behavior. The results of the experimental program indicate that the panels with stiffer cores generally exhibited a higher degree of degradation than panels with more flexible cores. The findings of this study indicate that the proposed panels represent a versatile construction system which can be configured to achieve the specific design demands for civil engineering infrastructure applications. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Dawood, M.] Univ Houston, Dept Civil & Environm Engn, Houston, TX 77204 USA. [Taylor, E.] USA, Corps Engineers Area Off, Ft Bragg, NC 28310 USA. [Ballew, W.] Martin Marietta Composites, Raleigh, NC USA. [Rizkalla, S.] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. RP Dawood, M (reprint author), Univ Houston, Dept Civil & Environm Engn, N107 Engn Bldg 1,4800 Calhoun Rd, Houston, TX 77204 USA. EM mmdawood@uh.edu OI Dawood, Mina/0000-0003-1941-1240 FU National Science Foundation (NSF) Industry/University Cooperative Research Center (I/UCRC) [0741676] FX The authors would like to acknowledge the support of Martin Marietta Composites through the National Science Foundation (NSF) Industry/University Cooperative Research Center (I/UCRC) on Repair of Buildings and Bridges with Composites (RB2C), award number 0741676. The authors would also like to thank Dr. Halit Cenan Mertol, Mr. Jason Patrick, and Mr. Charles DeVoto for their assistance in completing the static tests of the panels. NR 19 TC 8 Z9 10 U1 2 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD JUL PY 2010 VL 41 IS 5 BP 363 EP 374 DI 10.1016/j.compositesb.2010.02.006 PG 12 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 614NW UT WOS:000279067500003 ER PT J AU Sevkat, E Liaw, B Delale, F Raju, BB AF Sevkat, Ercan Liaw, Benjamin Delale, Feridun Raju, Basavaraju B. TI Effect of repeated impacts on the response of plain-woven hybrid composites SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Hybrid; Impact behavior; Ultrasonics; Resin transfer molding ID DAMAGE ACCUMULATION; EPOXY COMPOSITES; FIBER; STRENGTH; BEHAVIOR; TENSILE; SYSTEMS; SINGLE AB The repeated low-velocity impact responses of hybrid plain-woven composite panels were studied by drop-weight experiments. Non-hybrid S2-glass-fiber/toughened epoxy and IM7 graphite fiber/toughened epoxy as well as hybrid S2-glass-IM7 graphite fiber/toughened epoxy composite panels were impacted repeatedly using a pressure-assisted Instron-Dynatup 8520 instrumented drop-weight impact tester. During the low-velocity impact tests, the time histories of impact forces, absorbed impact energies and panel central deflections were recorded. The relations between the impact force and central deflection, whose slope represented the dynamic contact stiffness, were then constructed. The damaged specimens were inspected visually and using the ultrasonic C-Scan method. The effects of hybridization and lay-up sequence on the repeated drop-weight impact responses of woven composites were investigated. It was observed that damage accumulations could be slowed down using hybridization. It was also witnessed that the lay-up configuration of a hybrid composite had a significant influence on damage accumulation rate. The hybrid specimens with glass-epoxy skins survived the double number of successive impacts compared to hybrid specimens with graphite-epoxy skins. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Sevkat, Ercan; Liaw, Benjamin; Delale, Feridun] CUNY City Coll, Dept Mech Engn, New York, NY 10031 USA. [Raju, Basavaraju B.] US Army RDECOM, TARDEC, Warren, MI 48397 USA. RP Sevkat, E (reprint author), New York City Coll Technol, Dept Mech Engn Technol, 300 Jay St, Brooklyn, NY 11201 USA. EM esevkat@citytech.cuny.edu FU US Army Research Office [DAAD19-03-1-00086]; City University of New York [80209-06 10]; CUNY Research Equipment Grant Competition [80212-12 04] FX This work was supported by US Army Research Office through Grant No. DAAD19-03-1-00086. Dr. Bruce LaMattina was the Program Manager. The authors also would like to express their thanks for funding from City University of New York through CUNY Collaborative Incentive Research Grants Program (80209-06 10) and CUNY Research Equipment Grant Competition (80212-12 04) for procuring part of the materials and equipment used in this research. NR 26 TC 25 Z9 26 U1 3 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD JUL PY 2010 VL 41 IS 5 BP 403 EP 413 DI 10.1016/j.compositesb.2010.01.001 PG 11 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA 614NW UT WOS:000279067500008 ER PT J AU Ender, MG AF Ender, Morten G. TI Invisible Wounds of War: Psychological and Cognitive Injuries, Their Consequences, and Services to Assist Recovery SO CONTEMPORARY SOCIOLOGY-A JOURNAL OF REVIEWS LA English DT Book Review C1 [Ender, Morten G.] US Mil Acad, West Point, NY 10996 USA. RP Ender, MG (reprint author), US Mil Acad, West Point, NY 10996 USA. EM morten.ender@usma.edu NR 1 TC 0 Z9 0 U1 1 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0094-3061 J9 CONTEMP SOCIOL JI Contemp. Sociol.-J. Rev. PD JUL PY 2010 VL 39 IS 4 BP 399 EP 402 PG 4 WC Sociology SC Sociology GA 707WN UT WOS:000286321700006 ER PT J AU Ender, MG AF Ender, Morten G. TI War Without End: The Iraq War in Context SO CONTEMPORARY SOCIOLOGY-A JOURNAL OF REVIEWS LA English DT Book Review C1 [Ender, Morten G.] US Mil Acad, West Point, NY 10996 USA. RP Ender, MG (reprint author), US Mil Acad, West Point, NY 10996 USA. EM morten.ender@usma.edu NR 1 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0094-3061 J9 CONTEMP SOCIOL JI Contemp. Sociol.-J. Rev. PD JUL PY 2010 VL 39 IS 4 BP 399 EP 402 PG 4 WC Sociology SC Sociology GA 707WN UT WOS:000286321700005 ER PT J AU Brooks, CW DeMartelaere, SL Johnson, AJ AF Brooks, Clifford W. DeMartelaere, Sheri L. Johnson, Anthony J. TI Spontaneous Subconjunctival Abscess Because of Haemophilus influenzae SO CORNEA LA English DT Article DE subconjunctival abscess; ocular infection; conjunctivitis; Haemophilus influenzae ID INFECTIOUS SCLERITIS; STRABISMUS SURGERY; EPITHELIAL-CELLS; PENETRATION AB Purpose: To report a case of a spontaneous subconjunctival abscess in a patient with no previous ocular surgery or trauma. Method: Case report. Results: We report a case of a subconjunctival abscess caused by Haemophilus influenzae after several days of worsening conjunctivitis. Computed tomography scans of the orbits confirmed an abscess cavity adjacent to the globe without orbital extension. The abscess was spontaneously draining at presentation and resolved completely with topical and oral antibiotic therapy. Conclusions: To our knowledge, this is the first-described case of spontaneous subconjunctival abscess formation in an immunocompetent individual unrelated to preexisting ocular pathology, previous ocular surgery, or trauma. H. influenzae species may possess the ability to penetrate an intact conjunctiva and develop subconjunctival abscess. We recommend that patients presenting with bacterial conjunctivitis be closely examined to rule out subconjunctival abscess, which may require additional aggressive medical or surgical management. C1 [Brooks, Clifford W.] Brooke Army Med Ctr, Ophthalmol Serv, MCHE SDO, Ft Sam Houston, TX 78234 USA. RP Brooks, CW (reprint author), Brooke Army Med Ctr, Ophthalmol Serv, MCHE SDO, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clifford.w.brooks@gmail.com NR 21 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-3740 J9 CORNEA JI Cornea PD JUL PY 2010 VL 29 IS 7 BP 833 EP 835 DI 10.1097/ICO.0b013e3181c58efe PG 3 WC Ophthalmology SC Ophthalmology GA 630DS UT WOS:000280253300022 PM 20489592 ER PT J AU Moawad, FJ Wong, RKH AF Moawad, Fouad J. Wong, Roy K. H. TI Modern management of achalasia SO CURRENT OPINION IN GASTROENTEROLOGY LA English DT Article DE achalasia; management; myotomy; pneumatic dilation ID LAPAROSCOPIC HELLER MYOTOMY; BOTULINUM TOXIN INJECTION; ESOPHAGEAL ACHALASIA; PNEUMATIC DILATION; FOLLOW-UP; DOR FUNDOPLICATION; BALLOON DILATATION; ESOPHAGOMYOTOMY; METAANALYSIS; OUTCOMES AB Purpose of review Achalasia is a chronic esophageal motility disorder characterized by incomplete lower esophageal sphincter relaxation and aperistalsis resulting in delayed esophageal emptying. Management is aimed at palliation of symptoms and improvement in quality of life. Multiple factors including demographics, severity of disease, and existing comorbidities influence management options. Recent findings Given its low rates of complications, surgical myotomy has become the preferred primary treatment, particularly in young males. However, recent studies describing favorable long-term outcomes for pneumatic dilation make this a reasonable option to consider as first-line therapy for achalasia. Summary Pneumatic dilation and surgical myotomy are the most effective therapeutic options for achalasia. Depending on local expertise, either option is acceptable as first-line therapy. There continues to be a limited role for other treatment modalities such as pharamacologic agents and botulinum toxin in certain patient populations. C1 [Moawad, Fouad J.; Wong, Roy K. H.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. RP Wong, RKH (reprint author), Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD USA. EM Roy.Wong@amedd.army.mil NR 37 TC 11 Z9 11 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0267-1379 J9 CURR OPIN GASTROEN JI Curr. Opin. Gastroenterol. PD JUL PY 2010 VL 26 IS 4 BP 384 EP 388 DI 10.1097/MOG.0b013e32833aaf4a PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 613YO UT WOS:000279021500013 PM 20502326 ER PT J AU Kraemer, WJ Dunn-Lewis, C Comstock, BA Thomas, GA Clark, JE Nindl, BC AF Kraemer, William J. Dunn-Lewis, Courtenay Comstock, Brett A. Thomas, Gwendolyn A. Clark, James E. Nindl, Bradley C. TI Growth Hormone, Exercise, and Athletic Performance: A Continued Evolution of Complexity SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID HEAVY-RESISTANCE EXERCISE; MOLECULAR-MASS VARIANTS; IN-VIVO BIOACTIVITY; TRAINED ADULT MALES; COLLAGEN-SYNTHESIS; SKELETAL-MUSCLE; HYPOPHYSECTOMIZED RATS; IMMUNOFUNCTIONAL ASSAY; CONNECTIVE-TISSUE; FACTOR RESPONSES AB KRAEMER, W.J., C. DUNN-LEWIS, B. A. COMSTOCK, G. A. THOMAS, J.E. CLARK, and B. C. NINDL. Growth hormone, exercise, and athletic performance: a continued evolution of complexity. Curr. Sports Med. Rep., Vol. 9, No. 4, pp. 242-252, 2010. Growth hormone (hGH) presents pleiotropic effects in many tissues encompassing a diverse range of physiological actions. Its complexity as a family of hormones with different isoforms and different somatotroph molecular functions continues to challenge the status quo of our understanding of its release, function, and signaling. Owing to the fact that the majority of the literature has viewed hGH from the perspective of the primary 22 kD monomer, further investigation is needed as to the influence and biological activity of other aggregate and splice variant isoforms that are released into circulation. Its role over the life span and with supplementation yields equivocal results with more study needed. Testing for the use of hGH has progressed, and the first positive test was recently documented. Understanding of pituitary function and physiology will remain complex until the use of a broader range of analytical techniques, including assays, becomes mainstream. C1 [Kraemer, William J.] Univ Connecticut, Human Performance Lab, Dept Kinesiol, Unit 1110, Storrs, CT 06269 USA. [Kraemer, William J.] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Kraemer, WJ (reprint author), Univ Connecticut, Human Performance Lab, Dept Kinesiol, Unit 1110, 2095 Hillside Rd, Storrs, CT 06269 USA. EM William.Kraemer@uconn.edu OI Dunn-Lewis, Courtenay/0000-0002-2406-4215 NR 88 TC 19 Z9 19 U1 0 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X EI 1537-8918 J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD JUL-AUG PY 2010 VL 9 IS 4 BP 242 EP 252 DI 10.1249/JSR.0b013e3181e976df PG 11 WC Sport Sciences SC Sport Sciences GA 622QI UT WOS:000279677900012 PM 20622543 ER PT J AU Lin, LY Decker, CF AF Lin, Leyi Decker, Catherine F. TI Respiratory Tract Infections in Athletes SO DM DISEASE-A-MONTH LA English DT Article ID MYCOPLASMA-PNEUMONIAE; PERTUSSIS; PULMONARY; EPISODES; RUNNERS; RISK C1 [Lin, Leyi] Walter Reed Army Med Ctr, Infect Dis Serv, Dept Internal Med, Washington, DC 20307 USA. [Decker, Catherine F.] Uniformed Serv Univ Hlth Sci, Div Infect Dis, Dept Internal Med, Natl Naval Med Ctr, Bethesda, MD 20814 USA. RP Lin, LY (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, Dept Internal Med, Washington, DC 20307 USA. NR 23 TC 2 Z9 2 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0011-5029 J9 DM-DIS MON JI DM-Dis.-a-Mon. PD JUL PY 2010 VL 56 IS 7 BP 407 EP 413 DI 10.1016/j.disamonth.2010.05.001 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 629QY UT WOS:000280216000003 PM 20621214 ER EF